TY - JOUR T1 - Reevaluation of silicosis and lung cancer in North Carolina dusty trades workers. AN - 85255801; pmid-1415283 AB - We previously reported on the lung cancer mortality through 1983 of 760 males who were diagnosed with silicosis during 1930-1983 by the State of North Carolina's medical examination program for dusty trades workers. The lung cancer SMR (95% confidence interval) was 2.6 (1.8-3.6) among 655 white members of this group. In this paper, we report the results of a reanalysis of mortality among a subgroup for whom chest radiographs were currently available for rereading. Technically acceptable radiographs were available for 306 white males and were independently reclassified for pneumoconiosis by 3 "B" readers using the 1980 ILO Classification. Lung cancer SMRs were 1.7 (0.8-3.1) for the entire group of 306 white males, 2.5 (1.1-4.9) for 143 subjects reclassified as simple silicosis, and 1.0 (0.1-3.5) for 96 subjects whose radiographs were reclassified as ILO category 0. There were no lung cancer deaths among 67 subjects whose radiographs were reclassified as progressive massive fibrosis. Corresponding lung cancer SMRs for subjects who had never been employed in a job with exposure to known occupational carcinogens were 1.2 (0.2-4.4) for those reclassified as category 0, and 2.4 (1.0-5.0) for those reclassified as having simple silicosis. The age-adjusted lung cancer rate ratio among subjects with simple silicosis compared to those with category 0 was 1.5 (0.4-5.8). Our findings from this reanalysis, which effectively controls for misclassification of silicosis due to errors in radiograph interpretation by North Carolina program readers, offer additional evidence consistent with the hypothesis of an association between silicosis and lung cancer in this study group. JF - American Journal of Industrial Medicine AU - Amandus, H E AU - Castellan, R M AU - Shy, C AU - Heineman, E F AU - Blair, A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. PY - 1992 SP - 147 EP - 153 VL - 22 IS - 2 SN - 0271-3586, 0271-3586 KW - Smoking KW - Evaluation Studies KW - Lung Neoplasms KW - Human KW - Silicosis KW - Adult KW - North Carolina KW - Aged KW - Middle Age KW - Follow-Up Studies KW - Occupational Diseases KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85255801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Reevaluation+of+silicosis+and+lung+cancer+in+North+Carolina+dusty+trades+workers.&rft.au=Amandus%2C+H+E%3BCastellan%2C+R+M%3BShy%2C+C%3BHeineman%2C+E+F%3BBlair%2C+A&rft.aulast=Amandus&rft.aufirst=H&rft.date=1992-01-01&rft.volume=22&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers. AN - 73436415; 1463030 AB - We investigated the cardiotoxic effects of 1,1,2-Trichloro-1,2,2- Trifluoroethane (fluorocarbon 113 or FC113) exposures among healthy workers cleaning rocket and ground support equipment for the National Aeronautic and Space Administration (NASA) programs. Exposure and ambulatory electrocardiographic (ECG) monitoring data were evaluated on 16 workers, each of whom was examined on exposed and nonexposed workdays. We examined whether there was a greater rate of dysrhythmias on an exposed workday relative to a nonexposed workday. Overall, we found no within subject differences in the rate of ventricular and supraventricular premature beats (number per 1,000 heart beats), fluctuations in the length of the P-R interval, or heart rate. We found that levels of FC113 exposures below the Occupational Safety and Health Administration (OSHA) 8-hour time-weighted-average (TWA) standard of 1,000 ppm did not induce cardiac dysrhythmias or subtle changes in cardiac activity. However, because fluorocarbons may sensitize the heart to epinephrine, this study's negative findings based on sedentary and fairly healthy workers may not be generalizable to other populations of workers who are not as healthy or engaged in more physically demanding work. JF - American journal of industrial medicine AU - Egeland, G M AU - Bloom, T F AU - Schnorr, T M AU - Hornung, R W AU - Suruda, A J AU - Wille, K K AD - National Institute for Occupational Safety and Health, Industrywide Studies Branch, Cincinnati, OH 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 851 EP - 857 VL - 22 IS - 6 SN - 0271-3586, 0271-3586 KW - Chlorofluorocarbons, Ethane KW - 0 KW - Chlorofluorocarbons, Methane KW - 1,1,1-trichloro-2,2,2-trifluoroethane KW - 07H0R79HO0 KW - Index Medicus KW - Space life sciences KW - Electrocardiography, Ambulatory KW - Humans KW - Adult KW - Male KW - Female KW - Occupational Exposure KW - Arrhythmias, Cardiac -- diagnosis KW - Arrhythmias, Cardiac -- chemically induced KW - Space Flight KW - Chlorofluorocarbons, Methane -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73436415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Fluorocarbon+113+exposure+and+cardiac+dysrhythmias+among+aerospace+workers.&rft.au=Egeland%2C+G+M%3BBloom%2C+T+F%3BSchnorr%2C+T+M%3BHornung%2C+R+W%3BSuruda%2C+A+J%3BWille%2C+K+K&rft.aulast=Egeland&rft.aufirst=G&rft.date=1992-01-01&rft.volume=22&rft.issue=6&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-11 N1 - Date created - 1993-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outbreak of hypersensitivity pneumonitis among mushroom farm workers. AN - 73399712; 1463031 AB - Between April 1982 and August 1985, seven cases of mushroom worker's lung (MWL), a form of hypersensitivity pneumonitis, were diagnosed among workers at one mushroom farm in Florida. The cases suffered from episodic shortness of breath, cough, fever and chills, myalgia, malaise, and difficulty breathing. Pulmonary function testing revealed restrictive ventilatory impairment and reduced diffusing capacity; chest radiographs exhibited diffuse interstitial pulmonary infiltrates. The seven cases occurred among workers from different farm operations, suggesting that workers throughout the farm were exposed to the disease causing agent(s). Six of the affected workers left employment at the farm in order to remain free of symptoms. The other affected worker was able to continue working at the farm, but only by remaining in a maintenance shop which was physically separated from the rest of the farm facilities. An industrial hygiene survey demonstrated that farm workers from every work area were exposed to organic dust constituents suspected of causing MWL, but no specific antigens were identified as the cause of the cases. Of the remaining workers who participated in a cross-sectional respiratory morbidity survey at the farm, approximately 20% of the more heavily exposed workers reported occasionally experiencing symptoms consistent with MWL. Approximately 10% of the workers had below normal spirometry test results, but interpretation was hampered by the diverse racial makeup of the population and lack of an adequate comparison group. No abnormalities consistent with either acute or chronic MWL were seen on the chest radiographs. Serologic tests demonstrated that almost all workers had been exposed to antigens capable of causing MWL, but the results were not associated with health status. At the time of the cross-sectional survey, no workers were found to be suffering acute respiratory problems consistent with MWL. JF - American journal of industrial medicine AU - Sanderson, W AU - Kullman, G AU - Sastre, J AU - Olenchock, S AU - O'Campo, A AU - Musgrave, K AU - Green, F AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1992 PY - 1992 DA - 1992 SP - 859 EP - 872 VL - 22 IS - 6 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Respiratory Function Tests KW - Cross-Sectional Studies KW - Lung -- diagnostic imaging KW - Serologic Tests KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Radiography KW - Male KW - Female KW - Florida -- epidemiology KW - Basidiomycota KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- diagnosis KW - Disease Outbreaks KW - Alveolitis, Extrinsic Allergic -- epidemiology KW - Alveolitis, Extrinsic Allergic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73399712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Outbreak+of+hypersensitivity+pneumonitis+among+mushroom+farm+workers.&rft.au=Sanderson%2C+W%3BKullman%2C+G%3BSastre%2C+J%3BOlenchock%2C+S%3BO%27Campo%2C+A%3BMusgrave%2C+K%3BGreen%2C+F&rft.aulast=Sanderson&rft.aufirst=W&rft.date=1992-01-01&rft.volume=22&rft.issue=6&rft.spage=859&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-11 N1 - Date created - 1993-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A mortality study of workers at seven beryllium processing plants. AN - 73385040; 1463033 AB - The International Agency for Research on Cancer (IARC) has found that the evidence for the carcinogenicity of beryllium is sufficient based on animal data but "limited" based on human data. This analysis reports on a retrospective cohort mortality study among 9,225 male workers employed at seven beryllium processing facilities for at least 2 days between January 1, 1940, and December 31, 1969. Vital status was ascertained through December 31, 1988. The standardized mortality ratio (SMR) for lung cancer in the total cohort was 1.26 (95% confidence interval [CI] = 1.12-1.42); significant SMRs for lung cancer were observed for two of the oldest plants located in Lorain, Ohio (SMR = 1.69; 95% CI = 1.28-2.19) and Reading, Pennsylvania (SMR = 1.24; 95% CI = 1.03-1.48). For the overall cohort, significantly elevated SMRs were found for "all deaths" (SMR = 1.05; 95% CI = 1.01-1.08), "ischemic heart disease" (SMR = 1.08; 95% CI = 1.01-1.14), "pneumoconiosis and other respiratory diseases" (SMR = 1.48; 95% CI = 1.21-1.80), and "chronic and unspecified nephritis, renal failure, and other renal sclerosis" (SMR = 1.49; 95% CI = 1.00-2.12). Lung cancer SMRs did not increase with longer duration of employment, but did increase with longer latency (time since first exposure). Lung cancer was particularly elevated (SMR = 3.33; 95% CI = 1.66-5.95) among workers at the Lorain plant with a history of (primarily) acute beryllium disease, which is associated with very high beryllium exposure. The lung cancer excess was not restricted to plants operating in the 1940s, when beryllium exposures were known to be extraordinarily high. Elevated lung cancer SMRs were also observed for four of the five plants operating in the 1950s for workers hired during that decade. Neither smoking nor geographic location fully explains the increased lung cancer risk. Occupational exposure to beryllium compounds is the most plausible explanation for the increased risk of lung cancer observed in this study. Continued mortality follow-up of this cohort will provide a more definitive assessment of lung cancer risk at the newer plants and among cohort members hired in the 1950s or later at the older plants. Further clarification of the potential for specific beryllium compounds to induce lung cancer in humans, and the possible contribution of other exposures in specific processes at these plants, would require a nested case-control study. We are currently assessing whether available industrial hygiene data would support such an analysis. JF - American journal of industrial medicine AU - Ward, E AU - Okun, A AU - Ruder, A AU - Fingerhut, M AU - Steenland, K AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 885 EP - 904 VL - 22 IS - 6 SN - 0271-3586, 0271-3586 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Ohio -- epidemiology KW - Berylliosis -- mortality KW - Pennsylvania -- epidemiology KW - Male KW - Cause of Death KW - Survival Analysis KW - Cardiovascular Diseases -- mortality KW - Respiration Disorders -- mortality KW - Beryllium -- adverse effects KW - Lung Neoplasms -- mortality KW - Cardiovascular Diseases -- chemically induced KW - Lung Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced KW - Respiration Disorders -- chemically induced KW - Chemical Industry KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73385040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=A+mortality+study+of+workers+at+seven+beryllium+processing+plants.&rft.au=Ward%2C+E%3BOkun%2C+A%3BRuder%2C+A%3BFingerhut%2C+M%3BSteenland%2C+K&rft.aulast=Ward&rft.aufirst=E&rft.date=1992-01-01&rft.volume=22&rft.issue=6&rft.spage=885&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-11 N1 - Date created - 1993-01-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 2001 Sep;40(3):284-8 [11598976] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of chemical toxicity by modification of caloric intake. AN - 73334884; 1442303 AB - Caloric restriction increases maximum achievable lifespan and offsets the time to development of degenerative disease. Part of these desirable effects may result from positive modulation of toxic events. We have shown that when rodents are placed on a diet that is reduced in total calories by 40%, several beneficial changes on biochemical systems which impact on toxicologic processes are positively enhanced. Lipid metabolism is reduced and, therefore, the potential for lipoperoxidation is reduced. Additionally, activity of enzymes that produce free radicals as byproducts (cytochrome P4502C11) are also reduced. Concurrently, we have shown that the "effective" activity of catalase and the activity of superoxide dismutase (which are required for the detoxification of toxic oxygen radicals) are significantly increased by caloric restriction. The activities of enzymes of drug and xenobiotic metabolism are also altered by caloric restriction. The effect upon activity may be to either decrease or increase activity, dependent upon whether the enzyme activates compounds to intermediates which may be more toxic or whether the enzyme acts to reduce toxicity. We have also shown that caloric restriction may affect the initiation stage of carcinogenesis. Aflatoxin B1 binding to hepatic nuclear DNA was reduced by caloric restriction (caloric restriction reduced both major adducts that are formed upon exposure to aflatoxin B1). caloric restriction also reduced cytochrome P4502C11 which converts aflatoxin B1 to its toxic epoxide, and may partly explain the reduction in binding. These results suggest that caloric restriction may, in part, extend the time to development of degenerative disease by altering basic biochemical mechanisms of toxicity. JF - Advances in experimental medicine and biology AU - Hart, R W AU - Leakey, J E AU - Chou, M AU - Duffy, P H AU - Allaben, W T AU - Feuers, R J AD - National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1992 PY - 1992 DA - 1992 SP - 73 EP - 81 VL - 322 SN - 0065-2598, 0065-2598 KW - Carcinogens KW - 0 KW - Free Radicals KW - Index Medicus KW - Animals KW - Survival Rate KW - Humans KW - Carcinogens -- toxicity KW - Body Weight -- physiology KW - Liver -- metabolism KW - Nutritional Physiological Phenomena KW - Energy Intake KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73334884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Modulation+of+chemical+toxicity+by+modification+of+caloric+intake.&rft.au=Hart%2C+R+W%3BLeakey%2C+J+E%3BChou%2C+M%3BDuffy%2C+P+H%3BAllaben%2C+W+T%3BFeuers%2C+R+J&rft.aulast=Hart&rft.aufirst=R&rft.date=1992-01-01&rft.volume=322&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-23 N1 - Date created - 1992-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Victoria M. Trasko: champion of state-based surveillance of occupational diseases in the United States, 1937 to 1971. AN - 73170857; 1519623 AB - Victoria M. Trasko (1907-1979), a relatively unknown figure to many currently practicing occupational health specialists, was a pioneer in state-based surveillance of occupational diseases in the United States. To highlight her accomplishments during her career with the United States Public Health Service from 1937 to 1971, this report briefly reviews her publications on occupational disease surveillance. Her span of work includes guidelines for state industrial hygiene programs, numbers of workers in state occupational health programs, compilation of state and local laws related to industrial hygiene, proposals for standardized reporting of occupational disease, and analysis of trends in workers' compensation and mortality statistics for occupational diseases. She pilot tested the first state-based model system for occupational disease reporting in the United States. She documented the great difficulty experienced by states in getting physicians to report cases of occupational diseases, and pointed out that surveillance of other existing data sources was worthwhile, at least for some occupational diseases. She was the first to report on the distribution of silicosis cases in the United States by state, industry, and job title. She was the first to comment on mortality trends for the pneumoconioses and to document problems in comparability between different International Classification of Disease (ICD) periods. JF - American journal of industrial medicine AU - Costa, C A AU - Castellan, R M AU - Richards, T B AU - Yaffe, C D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1992 PY - 1992 DA - 1992 SP - 419 EP - 428 VL - 22 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - History of medicine KW - Trasko KW - United States KW - Silicosis -- prevention & control KW - Silicosis -- history KW - History, 20th Century KW - United States Public Health Service -- history KW - Humans KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- history KW - Pneumoconiosis -- history KW - Pneumoconiosis -- prevention & control KW - National Institutes of Health (U.S.) -- history KW - Occupational Health -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73170857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Victoria+M.+Trasko%3A+champion+of+state-based+surveillance+of+occupational+diseases+in+the+United+States%2C+1937+to+1971.&rft.au=Costa%2C+C+A%3BCastellan%2C+R+M%3BRichards%2C+T+B%3BYaffe%2C+C+D&rft.aulast=Costa&rft.aufirst=C&rft.date=1992-01-01&rft.volume=22&rft.issue=3&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-08 N1 - Date created - 1992-10-08 N1 - Date revised - 2017-01-13 N1 - People - Trasko N1 - Last updated - 2017-01-17 N1 - SubjectsTermNotLitGenreText - Trasko ER - TY - JOUR T1 - Binding characteristics of ortho-toluidine to rat hemoglobin and albumin. AN - 73161801; 1514920 AB - The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) were isolated from blood, and OT binding was determined by liquid scintillation counting. For Alb, peak binding occurred at 50 mg/kg at the 4-h time point (15.6 ng OT/mg Alb), while for Hb peak binding was observed at 24 h at the 100 mg/kg dose (23.0 +/- 5.1 ng OT/mg Hb). OT-Alb binding was not linear; however, OT-Hb binding appeared to increase linearly in a dose-dependent manner. Biological half-lives of OT bound to Alb or Hb were observed to be 2.6 and 12.3 days, respectively, after rats were administered a single dose of [14C]OT and sacrificed after 4 h to 28 days. The effect of route of administration on OT-Hb adduct formation was investigated, and approximately a two-fold increase in radioactivity bound to Hb was observed after i.p. administration of 100 mg/kg [14C]OT versus oral intubation. Additional studies were carried out to investigate the effect of microsomal enzyme induction. An increase in OT-Hb binding was seen in rats pretreated with phenobarbital compared to rats pretreated with beta-naphthoflavone or without pretreatment; however, this increase was not statistically significant. These results suggest that OT-Hb and OT-Alb adduct formation may be a valuable biomarker for assessing workplace exposure. JF - Archives of toxicology AU - DeBord, D G AU - Swearengin, T F AU - Cheever, K L AU - Booth-Jones, A D AU - Wissinger, L A AD - Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 231 EP - 236 VL - 66 IS - 4 SN - 0340-5761, 0340-5761 KW - Albumins KW - 0 KW - Biomarkers KW - Blood Proteins KW - Hemoglobins KW - Toluidines KW - 2-toluidine KW - B635MZ0ZLU KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Occupational Exposure KW - Evaluation Studies as Topic KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Blood Proteins -- metabolism KW - Time Factors KW - Biomarkers -- blood KW - Male KW - Albumins -- metabolism KW - Toluidines -- metabolism KW - Hemoglobins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73161801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Binding+characteristics+of+ortho-toluidine+to+rat+hemoglobin+and+albumin.&rft.au=DeBord%2C+D+G%3BSwearengin%2C+T+F%3BCheever%2C+K+L%3BBooth-Jones%2C+A+D%3BWissinger%2C+L+A&rft.aulast=DeBord&rft.aufirst=D&rft.date=1992-01-01&rft.volume=66&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-29 N1 - Date created - 1992-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Much remains to be done. AN - 73129755; 1504179 JF - American Indian and Alaska native mental health research : journal of the National Center AU - Gregory, D AD - Indian Health Service, Portland, Oregon 97204. Y1 - 1992 PY - 1992 DA - 1992 SP - 89 EP - 94; discussion 126-32 VL - 4 IS - 3 SN - 0893-5394, 0893-5394 KW - Psychotropic Drugs KW - 0 KW - Street Drugs KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Health Education -- legislation & jurisprudence KW - Alcoholism -- rehabilitation KW - Indians, North American -- legislation & jurisprudence KW - Health Policy -- legislation & jurisprudence KW - Indians, North American -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73129755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Indian+and+Alaska+native+mental+health+research+%3A+journal+of+the+National+Center&rft.atitle=Much+remains+to+be+done.&rft.au=Gregory%2C+D&rft.aulast=Gregory&rft.aufirst=D&rft.date=1992-01-01&rft.volume=4&rft.issue=3&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=American+Indian+and+Alaska+native+mental+health+research+%3A+journal+of+the+National+Center&rft.issn=08935394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-24 N1 - Date created - 1992-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Exposure to diesel exhaust in the trucking industry and possible relationships with lung cancer. AN - 73045443; 1621697 AB - We previously reported that long-term truck drivers and mechanics in the Teamsters Union had higher lung cancer risks than Teamsters outside the trucking industry. We now summarize results from an industrial hygiene survey of current exposures to diesel exhaust in the trucking industry, and relate these to our prior results pertaining to lung cancer risk. JF - American journal of industrial medicine AU - Steenland, K AU - Silverman, D AU - Zaebst, D AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 887 EP - 890 VL - 21 IS - 6 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Fuel Oils KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Air Pollutants, Occupational -- analysis KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Carbon -- analysis KW - Occupational Exposure -- analysis KW - Transportation KW - Lung Neoplasms -- epidemiology KW - Fuel Oils -- adverse effects KW - Occupational Diseases -- epidemiology KW - Lung Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73045443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Exposure+to+diesel+exhaust+in+the+trucking+industry+and+possible+relationships+with+lung+cancer.&rft.au=Steenland%2C+K%3BSilverman%2C+D%3BZaebst%2C+D&rft.aulast=Steenland&rft.aufirst=K&rft.date=1992-01-01&rft.volume=21&rft.issue=6&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-03 N1 - Date created - 1992-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 1993 Aug;24(2):257, 259 [8213854] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Silica exposure in hand grinding steel castings. AN - 72963411; 1317091 AB - Exposure to silica dust was studied in the grinding of castings in a steel foundry that used conventional personal sampling methods and new real-time sampling techniques developed for the identification of high-exposure tasks and tools. Approximately one-third of the personal samples exceeded the National Institute for Occupational Safety and Health recommended exposure limit for crystalline silica, a fraction similar to that identified in other studies of casting cleaning. Of five tools used to clean the castings, the tools with the largest wheels, a 6-in. grinder and a 4-in. cutoff wheel, were shown to be the major sources of dust exposure. Existing dust control consisted of the use of downdraft grinding benches. The size of the casting precluded working at a distance close enough to the grates of the downdraft benches for efficient capture of the grinding dust. In addition, measurements of air recirculated from the downdraft benches indicated that less than one-half of the respirable particles were removed from the contaminated airstream. Previous studies have shown that silica exposures in the cleaning of castings can be reduced or eliminated through the use of mold coatings, which minimize sand burn-in on the casting surface; by application of high-velocity, low-volume exhaust hoods; and by the use of a nonsilica molding aggregate such as olivine. This study concluded that all these methods would be appropriate control options. JF - American Industrial Hygiene Association journal AU - O'Brien, D AU - Froehlich, P A AU - Gressel, M G AU - Hall, R M AU - Clark, N J AU - Bost, P AU - Fischbach, T AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226-1998. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 42 EP - 48 VL - 53 IS - 1 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Evaluation Studies as Topic KW - Environmental Monitoring KW - Air Pollution -- prevention & control KW - Ventilation -- methods KW - Maximum Allowable Concentration KW - Humans KW - Ventilation -- standards KW - Silicon Dioxide -- analysis KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72963411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Silica+exposure+in+hand+grinding+steel+castings.&rft.au=O%27Brien%2C+D%3BFroehlich%2C+P+A%3BGressel%2C+M+G%3BHall%2C+R+M%3BClark%2C+N+J%3BBost%2C+P%3BFischbach%2C+T&rft.aulast=O%27Brien&rft.aufirst=D&rft.date=1992-01-01&rft.volume=53&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-25 N1 - Date created - 1992-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Performance of laboratories measuring silica in the Proficiency Analytical Testing program. AN - 72959590; 1317092 AB - A statistical study was performed on the results reported by laboratories analyzing silica samples in the first 101 rounds of the Proficiency Analytical Testing (PAT) program. Five laboratories participated in the first round of the PAT program in 1972, and participation grew to 130 laboratories before falling to 105 in Round 101. The laboratories use all three of the major methods of analysis: colorimetry, x-ray diffractometry, and infrared spectroscopy. The objectives of the study were to determine bias between methods, the variability associated with the methods, and any changes in bias or variability caused by a number of factors. The colorimetric method has consistently given the lowest results, particularly at higher loadings. X-ray diffractometry results were biased higher than infrared spectroscopy results during one period but not in the following period. Between the two periods, the procedures and materials used to prepare PAT samples changed in a number of ways, but the switch to quartz dust with a smaller particle size is a likely explanation for the bias difference. Generally, silica analyses have improved in precision over time, and this improvement has taken place for all three of the methods. The colorimetric method has shown the poorest precision of the three methods, but, unlike the differences in bias, the differences in precision have diminished considerably over time. Precision estimates from other studies were compared to those from this study to learn more about sources of variability. The largest source of variability, the differences between laboratories, was large even when laboratories used the same method, as they did in a collaborative study of silica methods. JF - American Industrial Hygiene Association journal AU - Shulman, S A AU - Groff, J H AU - Abell, M T AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 49 EP - 56 VL - 53 IS - 1 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - United States KW - Evaluation Studies as Topic KW - Reproducibility of Results KW - X-Ray Diffraction KW - Spectrophotometry, Infrared -- standards KW - Humans KW - Colorimetry -- standards KW - United States Occupational Safety and Health Administration KW - Bias (Epidemiology) KW - Quality Assurance, Health Care KW - Silicon Dioxide -- analysis KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72959590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Performance+of+laboratories+measuring+silica+in+the+Proficiency+Analytical+Testing+program.&rft.au=Shulman%2C+S+A%3BGroff%2C+J+H%3BAbell%2C+M+T&rft.aulast=Shulman&rft.aufirst=S&rft.date=1992-01-01&rft.volume=53&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-25 N1 - Date created - 1992-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fatal occupational injury related to helicopters in the United States 1980-1985. AN - 72855616; 1550537 AB - This paper discusses characteristics of occupational traumatic deaths, caused by helicopters, during 1980-1985. Death certificate data are used to describe demographic characteristics and causes of death. Information from National Transportation Safety Board (NTSB) investigations is used to describe pilot experience and environmental circumstances surrounding the incident. During 1980-1985, 374 worker deaths involving helicopters were identified in the National Traumatic Occupational Fatality (NTOF) database. The majority of deaths resulted from trauma to body organs (including the brain). According to NTSB investigations, 59% of crashes in this study were attributed to pilot error, compared to 16.5% from mechanical failure of the helicopter. Thirty percent of deaths were related to military use of helicopters. While death due to occupational exposure to helicopters is not common, some workers (e.g., helicopter pilots) appear to be at especially high risk. This group should be studied further to develop better strategies for their protection. JF - Aviation, space, and environmental medicine AU - Conroy, C AU - Russell, J C AU - Crouse, W E AU - Bender, T R AU - Holl, J A AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 67 EP - 71 VL - 63 IS - 1 SN - 0095-6562, 0095-6562 KW - Index Medicus KW - Space life sciences KW - United States KW - Drowning KW - Risk Factors KW - Humans KW - Adult KW - Professional Competence KW - Incidence KW - Military Personnel -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Aircraft KW - Accidents, Occupational -- statistics & numerical data KW - Accidents, Aviation -- mortality KW - Accidents, Occupational -- mortality KW - Accidents, Aviation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72855616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+space%2C+and+environmental+medicine&rft.atitle=Fatal+occupational+injury+related+to+helicopters+in+the+United+States+1980-1985.&rft.au=Conroy%2C+C%3BRussell%2C+J+C%3BCrouse%2C+W+E%3BBender%2C+T+R%3BHoll%2C+J+A&rft.aulast=Conroy&rft.aufirst=C&rft.date=1992-01-01&rft.volume=63&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+space%2C+and+environmental+medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-17 N1 - Date created - 1992-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of cyclophosphamide, total body irradiation, and zidovudine on retrovirus proliferation and disease progression in murine AIDS. AN - 72798895; 1310603 AB - Murine acquired immunodeficiency syndrome (MAIDS) develops when C57B1/6 mice are inoculated with LP-BM5 murine leukemia viruses. Disease progression in these animals is characterized by lymphadenopathy, polyclonal B-cell activation, severe immunodeficiency, and death. Mice with MAIDS have been used to examine the efficacy of antiretroviral therapies for possible use in AIDS patients. In the present work, MAIDS mice were employed to test the hypothesis that established retroviral infection might be cured by the combined use of a cytotoxic agent (cyclophosphamide) and total body irradiation--a regimen reported to have successfully cured HIV-1 infection in one AIDS patient. Results indicate that the ablation of retrovirus-infected lymphoid cells reduced but did not eliminate LP-BM5 infection. Moreover, this regimen was no more effective at controlling virus proliferation or preventing the polyclonal IgG activation characteristic of murine AIDS than was AZT alone. JF - AIDS research and human retroviruses AU - Klinman, D M AU - Krieg, A AU - Conover, J AU - Ussery, M A AU - Black, P L AD - Laboratory of Retrovirus Research, CBER, FDA, Bethesda, MD. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 101 EP - 106 VL - 8 IS - 1 SN - 0889-2229, 0889-2229 KW - Zidovudine KW - 4B9XT59T7S KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - AIDS/HIV KW - Lymphocyte Activation -- drug effects KW - Leukemia, Experimental -- radiotherapy KW - B-Lymphocytes -- drug effects KW - Animals KW - Lymphocyte Activation -- radiation effects KW - Leukemia, Experimental -- drug therapy KW - B-Lymphocytes -- radiation effects KW - Mice, Inbred C57BL KW - Mice KW - B-Lymphocytes -- immunology KW - Leukemia, Experimental -- microbiology KW - Female KW - Bone Marrow Transplantation KW - Zidovudine -- therapeutic use KW - Leukemia Virus, Murine -- radiation effects KW - Whole-Body Irradiation KW - Cyclophosphamide -- therapeutic use KW - Virus Replication -- radiation effects KW - Virus Replication -- drug effects KW - Zidovudine -- pharmacology KW - Leukemia Virus, Murine -- drug effects KW - Murine Acquired Immunodeficiency Syndrome -- radiotherapy KW - Murine Acquired Immunodeficiency Syndrome -- microbiology KW - Murine Acquired Immunodeficiency Syndrome -- drug therapy KW - Cyclophosphamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72798895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=Effect+of+cyclophosphamide%2C+total+body+irradiation%2C+and+zidovudine+on+retrovirus+proliferation+and+disease+progression+in+murine+AIDS.&rft.au=Klinman%2C+D+M%3BKrieg%2C+A%3BConover%2C+J%3BUssery%2C+M+A%3BBlack%2C+P+L&rft.aulast=Klinman&rft.aufirst=D&rft.date=1992-01-01&rft.volume=8&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-17 N1 - Date created - 1992-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Review of fluoride benefits and risks: report of the Ad Hoc Subcommittee on Fluoride of the Committee to Coordinate Environmental Health and Related Programs, February 1991 AN - 59604721; 1992-0900657 AB - Review of studies on the cavity-reducing effects vs. carcinogenic risks of fluoridated drinking water. Recommends continued support for optimal fluoridation of drinking water. JF - Atlanta, GA 30333, 1992. 134+ pp. Y1 - 1992///0, PY - 1992 DA - 0, 1992 EP - 134+ PB - Atlanta, GA 30333 KW - Water supply -- Fluoridation KW - Public health -- United States KW - United States -- Health policy KW - Drinking water -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59604721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=134%2B&rft.isbn=&rft.btitle=Review+of+fluoride+benefits+and+risks%3A+report+of+the+Ad+Hoc+Subcommittee+on+Fluoride+of+the+Committee+to+Coordinate+Environmental+Health+and+Related+Programs%2C+February+1991&rft.title=Review+of+fluoride+benefits+and+risks%3A+report+of+the+Ad+Hoc+Subcommittee+on+Fluoride+of+the+Committee+to+Coordinate+Environmental+Health+and+Related+Programs%2C+February+1991&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Atlanta, GA 30333 pa N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - 29. Immunity and vaccine development. AN - 16693080; 2979426 JF - AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC (USA). pp. 491-504. 1992. AU - Ellison, J S AU - Olson, L D AU - Barile, M F A2 - Maniloff, J A2 - McElhaney, RN A2 - Finch, LR A2 - Baseman, JB (eds) Y1 - 1992 PY - 1992 DA - 1992 SP - 14 EP - 504 PB - AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC (USA) SN - 1555810500 KW - Microbiology Abstracts B: Bacteriology KW - vaccines KW - lung KW - immune response (cell-mediated) KW - infection KW - virulence KW - disease control KW - Mycoplasma pneumoniae KW - antigens KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16693080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Ellison%2C+J+S%3BOlson%2C+L+D%3BBarile%2C+M+F&rft.aulast=Ellison&rft.aufirst=J&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=491&rft.isbn=1555810500&rft.btitle=29.+Immunity+and+vaccine+development.&rft.title=29.+Immunity+and+vaccine+development.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2012-02-28 ER - TY - BOOK T1 - Flow-injection assay of enzyme inhibition in fish using immobilized diamine oxidase. AN - 16595785; 3006365 AB - A flow-injection assay for inhibition of diamine oxidase (DAO) is described. Histamine in decomposed fish is detected and used as the enzyme substrate. Sample extracts are doubly injected; one of the two resulting sample zones is passed through a reactor containing DAO immobilized to Sepharose. Histamine is detected sequentially in both the pristine and enzymatically treated zones. The detection chemistry (kinetics-optimized condensation with phthalic dicarboxaldehyde) allows the selective detection of histamine. Subsequent calibration with histamine standard and comparison of the two peak heights allows generic detection of compounds inhibiting the DAO-mediated conversion of histamine. Preliminary data show that the system can detect inhibitors in extracts of decomposed Mahi-Mahi (associated with a Scombroid poisoning outbreak) and that far lower levels of inhibition are observed in fresh fish. Several known inhibitors and competitive substrates of DAO are also tested. JF - Analytica Chimica Acta [ANAL. CHIM. ACTA.]. Vol. 261, no. 1-2. 1992. AU - Hungerford, J M AU - Arefyev, A A Y1 - 1992 PY - 1992 DA - 1992 KW - amine oxidase (copper-containing) KW - analytical techniques KW - biological poisons KW - flow injection assay KW - fluorometry KW - food fish KW - histamine KW - histamines KW - immobilized enzymes KW - quality assurance KW - scombroid poisoning KW - Toxicology Abstracts; ASFA Marine Biotechnology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - enzymatic activity KW - food poisoning KW - seafood KW - Q4 27390:Toxins KW - X 24222:Analytical procedures KW - X 24173:Animals KW - Q4 27260:Immobilization KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16595785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hungerford%2C+J+M%3BArefyev%2C+A+A&rft.aulast=Hungerford&rft.aufirst=J&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Flow-injection+assay+of+enzyme+inhibition+in+fish+using+immobilized+diamine+oxidase.&rft.title=Flow-injection+assay+of+enzyme+inhibition+in+fish+using+immobilized+diamine+oxidase.&rft.issn=00032670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 ER - TY - BOOK T1 - Development of tolerance limits for an industry - ethylene oxide sterilization of medical devices. AN - 16589247; 51792 AB - This paper illustrates a use of probability plots in an unusual application - the development of limits for process parameters for the Ethylene Oxide (EO) sterilization industry. The results of the study provide lower and upper 1% and 10% limits for the values of several parameters. These are point estimate limits for the target values of the process parameters. EO is used to produce the majority of sterile medical devices. Compared with other sterilization procedures, EO sterilization is a poorly understood process. Food and Drug Administration (FDA) investigators collected detailed descriptions of procedures at 262 establishments, both domestic and foreign, in order to obtain a better understanding of industry practices. Probability plots were employed to screen data for outliers and to fit empirical cumulative distributions to process parameters. The plots were useful in identifying relationships among parameters and in developing both univariate and bivariate tolerance limits. This report focuses on the use and interpretation of probability plots for these applications. In December 1990, the FDA issued these limits as guidelines for its investigators in evaluating sterilization cycles employed by medical device manufacturers. The guidelines facilitate FDA investigations by providing a means of identifying processes where proof of the efficacy of the sterilization process is most needed. The limits should benefit EO sterilizers by informing them of where their process fits in the spectrum of other processes. Unusual values of process parameters should alert the sterilizer that this process is not in the mainstream. The limits are intended as guidance for the investigator and the producer. They should not be interpreted as requirements. JF - ASQC, MILWAUKEE, WI (USA). Vol. 46, pp. 741-747. 1992. AU - Madden, Dale A Y1 - 1992 PY - 1992 DA - 1992 SP - 7 EP - 747 PB - ASQC, MILWAUKEE, WI (USA) KW - Biomedical equipment KW - Ethyl oxide sterilization KW - Point estimate limits KW - Process control KW - Statistical methods KW - Sterilization (cleaning) KW - Tolerance limits KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Probability KW - Standards KW - W4 922.1:PROBABILITY THEORY KW - W4 902.2:CODES AND STANDARDS KW - W4 462.1:BIOMEDICAL EQUIPMENT (GENERAL) KW - W4 913.3:QUALITY ASSURANCE AND CONTROL KW - W4 731:AUTOMATIC CONTROL PRINCIPLES AND APPLICATIONS KW - W 30965:Miscellaneous, Reviews KW - W4 922.2:MATHEMATICAL STATISTICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16589247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Biotechnology+Research+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Madden%2C+Dale+A&rft.aulast=Madden&rft.aufirst=Dale&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=741&rft.isbn=&rft.btitle=Development+of+tolerance+limits+for+an+industry+-+ethylene+oxide+sterilization+of+medical+devices.&rft.title=Development+of+tolerance+limits+for+an+industry+-+ethylene+oxide+sterilization+of+medical+devices.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A review of physical exercises recommended for VDT operators. AN - 16491805; 2944578 AB - This paper presents an evaluation of exercises that have been recommended for the prevention of musculoskeletal discomfort among VDT/office workers. 127 individual exercises were analysed for their suitability for performance in VDT workplaces. Additionally, each exercise was judged in terms of its safety and its compliance with principles of physiotherapy. Results showed that, in the majority of cases, the prepared instructions for the exercises were satisfactory and the exercises could be readily performed at the workstation. However, over a third of the exercises were conspicuous and potentially embarrassing to perform, and half would significantly disrupt the work routine. Additionally, a number of the exercises posed potential safety hazards, exacerbated biomechanical stresses common to VDT work, or were contraindicated for persons with certain health problems. These findings suggest a need for greater attention to both the practical and the therapeutic aspects of exercises promoted for VDT users. JF - Applied Ergonomics AU - Lee, K AU - Swanson, N AU - Sauter, S AU - Wickstrom, R AU - Waikar, A AU - Mangum, M AD - NIOSH, Taft Lab., 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 387 EP - 408 VL - 23 IS - 6 SN - 0003-6870, 0003-6870 KW - video display terminals KW - musculoskeletal system KW - exercise KW - Health & Safety Science Abstracts KW - ergonomics KW - occupational health KW - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16491805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=A+review+of+physical+exercises+recommended+for+VDT+operators.&rft.au=Lee%2C+K%3BSwanson%2C+N%3BSauter%2C+S%3BWickstrom%2C+R%3BWaikar%2C+A%3BMangum%2C+M&rft.aulast=Lee&rft.aufirst=K&rft.date=1992-01-01&rft.volume=23&rft.issue=6&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; ergonomics ER - TY - JOUR T1 - A simple method to test condoms for penetration by viruses. AN - 16486155; 2936998 AB - A method by which virus penetration through condoms can be tested with simple, inexpensive equipment is described. The method uses Phi X174 bacteriophage as the challenge virus and physiologically relevant pressure. Penetration by 0.1 mu l (or less) of challenge suspension can be readily detected. As examples, latex and natural-membrane condoms were examined. JF - Applied and Environmental Microbiology AU - Lytle, C D AU - Routson, L B AU - Cyr, W H AD - Div. Life Sci., Cent. Devices and Radiol. Health, FDA, Rockville, MD 20857, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 3180 EP - 3182 VL - 58 IS - 7 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - penetration KW - phage Phi X174 KW - methodology KW - detection KW - condoms KW - latex KW - viruses KW - V 22124:Prophylaxis & control KW - A 01114:Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16486155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=A+simple+method+to+test+condoms+for+penetration+by+viruses.&rft.au=Lytle%2C+C+D%3BRoutson%2C+L+B%3BCyr%2C+W+H&rft.aulast=Lytle&rft.aufirst=C&rft.date=1992-01-01&rft.volume=58&rft.issue=7&rft.spage=3180&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2012-02-28 N1 - SubjectsTermNotLitGenreText - phage Phi X174; condoms; viruses; penetration; detection; latex; methodology ER - TY - JOUR T1 - Consequences of chemical modifications on the free radical reactions of human hemoglobin. AN - 16416254; 2895232 AB - Hemoglobin-based oxygen carriers (HBOCs) are candidates for use as blood substitutes and resuscitation fluids. HBOCs of specific types differ in their ability to generate or interact with free radicals. The differences do not correlate with oxygen affinity. Comparisons with unmodified human hemoglobin, HbA sub(0), were carried out with two cross-linked derivatives; HbA-FMDA, produced by the reaction of human oxyhemoglobin with fumaryl monodibromoaspirin, and HbA-DBBF, produced by the reaction of human deoxyhemoglobin with bis(3,5-dibromosalicyl) fumarate. The HBOCs also differ in rates of hemoglobin-catalyzed NADPH oxidation and aniline hydroxylation, reactions mediated by reactive oxygen species. The stereochemical differences brought about by chemical cross-linking alter the ability of HBOCs to generate radicals and to react with activated oxygen species. The ability of hemoglobin to produce activated species of oxygen can be enhanced or suppressed independently of oxygen affinity. JF - Archives of Biochemistry and Biophysics AU - Alayash, AI AU - Fratantoni, J C AU - Bonaventura, C AU - Bonaventura, J AU - Bucci, E AD - Cent. Biol. Eval. and Res., FDA, 8800 Rockville Pike, Build. 29, Rm. B-10, Bethesda, MD 20892, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 114 EP - 120 VL - 298 IS - 1 SN - 0003-9861, 0003-9861 KW - chemical modification KW - effects on KW - free radicals KW - haemoglobin KW - man KW - reaction KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16416254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Biochemistry+and+Biophysics&rft.atitle=Consequences+of+chemical+modifications+on+the+free+radical+reactions+of+human+hemoglobin.&rft.au=Alayash%2C+AI%3BFratantoni%2C+J+C%3BBonaventura%2C+C%3BBonaventura%2C+J%3BBucci%2C+E&rft.aulast=Alayash&rft.aufirst=AI&rft.date=1992-01-01&rft.volume=298&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Archives+of+Biochemistry+and+Biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Effective local exhaust ventilation for controlling formaldehyde exposures during embalming. AN - 16373922; 2877297 AB - Previous studies have found that formaldehyde exposures to embalmers during the embalming process exceeded current occupational health criteria and standards. There are currently just over 20,000 mortuaries in the United States, employing 75,000 people. A research study was conducted to develop and evaluate a local exhaust ventilation system to control formaldehyde exposures. The control design that was developed consisted of a pair of 6-ft-long slot hoods placed on each side of the embalming table. Through a series of laboratory tests, an optimum flow rate (20 m super(3)/min) was determined for the local exhaust ventilation system. The final design was field tested at a college of mortuary science to determine its effectiveness. JF - Applied Occupational & Environmental Hygiene AU - Gressel, M G AU - Hughes, R T AD - Dep. Health and Hum. Serv., Public Health Serv., Cent. Dis. Control, NIOSH, 4676 Columbia Parkway, Mailstop R-5, Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 840 EP - 845 VL - 7 IS - 12 SN - 1047-322X, 1047-322X KW - embalming KW - mortuaries KW - Health & Safety Science Abstracts KW - ventilation KW - indoor environments KW - air pollution control KW - formaldehyde KW - occupational exposure KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - H SI0.9.4:VENTILATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16373922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Effective+local+exhaust+ventilation+for+controlling+formaldehyde+exposures+during+embalming.&rft.au=Gressel%2C+M+G%3BHughes%2C+R+T&rft.aulast=Gressel&rft.aufirst=M&rft.date=1992-01-01&rft.volume=7&rft.issue=12&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational exposure; formaldehyde; ventilation; indoor environments; air pollution control ER - TY - JOUR T1 - Metal-based formulations with high microbicidal activity. AN - 16339121; 2842313 AB - Substances were evaluated for their relative potencies in inactivating Junin virus, Escherichia coli , and spores Bacillus subtilis . Under the conditions of our test, glutaraldehyde was the most efficient agent among all substances currently recommended for disinfecting and sterilizing medical devices. Either copper or iron ions by themselves were able to inactivate virus with an efficiency similar to that of substances currently used for disinfection and sterilization. The microbicidal effect of metals, however, was enhanced further by the addition of peroxide. The mixtures of copper and peroxide described here were more efficient than glutaraldehyde in inactivating viruses and bacteria. The addition of a metal chelator to metal-peroxide mixtures further increased the microbicidal potency of the reagent. The formulations described in this study should be harmless to people but able to quickly and efficiently inactivate microorganisms, particularly viruses. JF - Applied and Environmental Microbiology AU - Sagripanti, J-L AD - Mol. Biol. Branch (HFZ-113), Cent. Devices and Radiol. Health, FDA, Rockville, MD 20857, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 3157 EP - 3162 VL - 58 IS - 9 SN - 0099-2240, 0099-2240 KW - glutaraldehyde KW - copper KW - iron KW - hydrogen peroxide KW - chelators KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - disinfectants KW - Junin virus KW - spores KW - metals KW - Escherichia coli KW - antimicrobial agents KW - A 01069:Antimicrobial & microbiocidal KW - V 22100:Antiviral agents KW - J 02803:Antiseptics and disinfectants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16339121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Metal-based+formulations+with+high+microbicidal+activity.&rft.au=Sagripanti%2C+J-L&rft.aulast=Sagripanti&rft.aufirst=J-L&rft.date=1992-01-01&rft.volume=58&rft.issue=9&rft.spage=3157&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus subtilis; Escherichia coli; Junin virus; metals; antimicrobial agents; disinfectants; spores ER - TY - JOUR T1 - Differentiation of a rapidly growing, scotochromogenic, polycyclic-aromatic-hydrocarbon-metabolizing strain of Mycobacterium sp. from other known Mycobacterium species. AN - 16269427; 2792822 AB - A rapidly-growing, acid-alcohol fast, scotochromogenic, polycyclic-aromatic-hydrocarbon-degrading Mycobacterium sp. isolate, Pyr-1, which was different from known Mycobacterium species based on biochemical tests, was further analyzed to compare its mycolic acids, cellular proteins, and nucleic acids with those of known species. Mass spectral analysis of the mycolic acids of Mycobacterium sp. Pyr-1 indicated that its mycolic acids were C sub(60)H sub(120)O sub(3) and C sub(62)H sub(124)O sub(3). The mycolic acid pattern was unique, most closely resembling M. austroafricanum) but also resembling M. parafortuitum and M. gilvum . Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of soluble cellular proteins also readily differentiated this isolate from other species. JF - Archives of Microbiology AU - Rafii, F AU - Butler, W R AU - Cerniglia, CE AD - Div. Microbiol., Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 512 EP - 520 VL - 157 IS - 6 SN - 0302-8933, 0302-8933 KW - mycolic acid KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - biodegradation KW - Mycobacterium KW - characterization KW - mass spectroscopy KW - identification KW - polycyclic aromatic hydrocarbons KW - taxonomy KW - A 01063:Utilization KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16269427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Microbiology&rft.atitle=Differentiation+of+a+rapidly+growing%2C+scotochromogenic%2C+polycyclic-aromatic-hydrocarbon-metabolizing+strain+of+Mycobacterium+sp.+from+other+known+Mycobacterium+species.&rft.au=Rafii%2C+F%3BButler%2C+W+R%3BCerniglia%2C+CE&rft.aulast=Rafii&rft.aufirst=F&rft.date=1992-01-01&rft.volume=157&rft.issue=6&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Archives+of+Microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium; identification; taxonomy; mass spectroscopy; characterization; polycyclic aromatic hydrocarbons; biodegradation ER - TY - JOUR T1 - Real-time personal monitoring in the workplace using radio telemetry. AN - 16159679; 2697485 AB - A case study involving a furniture refinisher's exposure to methylene chloride is described here to demonstrate the utility of radio telemetry. The worker carried a radio transmitter that was attached to an air quality analyzer. Relative methylene chloride exposures were remotely observed on a video monitor throughout the day. Increases in exposure levels due to job tasks, work practices, and emission sources were immediately identified so that corrective action could be taken. JF - Applied Occupational & Environmental Hygiene AU - Kovein, R J AU - Hentz, P A AD - NIOSH, Div. Phys. Sci. and Eng., Eng. Control Technol. Branch, 4676 Columbia Parkw.-R5, Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 168 EP - 173 VL - 7 IS - 3 SN - 1047-322X, 1047-322X KW - air quality KW - methylene chloride KW - Pollution Abstracts KW - fumes KW - occupational health KW - remote sensing KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16159679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Real-time+personal+monitoring+in+the+workplace+using+radio+telemetry.&rft.au=Kovein%2C+R+J%3BHentz%2C+P+A&rft.aulast=Kovein&rft.aufirst=R&rft.date=1992-01-01&rft.volume=7&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - remote sensing; occupational health; fumes ER - TY - JOUR T1 - Control of wood dust from rotational hand-held sanders. AN - 16147931; 2700204 AB - An association between nasal cancer and other health effects and occupations involving exposure to wood dust has been clearly established in the literature. Therefore, it was deemed necessary to conduct research to develop new improved methods to control this dust. This article reports on the research that has been conducted by investigations at the National Institute for Occupational Safety and Health (NIOSH) on rotational hand-held sanders. A new control system was developed to be used in conjunction with existing controls that are used on these sanders, which consist of an aspirator and a perforated sanding disc pad. The new control system includes additional suction applied to the sander body and a specially designed, slotted sanding disc pad to relieve the increased pressing of the sander to the sanded surface imposed by the increased vacuum. The newly designed sanding disc pad also captures wood dust from the sanded surface directly at the pad periphery. The laboratory the new control system reduced the wood dust emissions by over 90 percent compared with emissions from the aspirator-controlled sanders that are currently in use. JF - APPL. OCCUP. ENVIRON. HEALTH. AU - Hampl, V AU - Topmiller, J L AU - Watkins, D S AU - Murdock, D J AD - NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 263 EP - 270 VL - 7 IS - 4 KW - occupational health KW - emission control KW - hand-held sanders KW - Health & Safety Science Abstracts; Pollution Abstracts KW - wood KW - dust KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI1.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16147931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=APPL.+OCCUP.+ENVIRON.+HEALTH.&rft.atitle=Control+of+wood+dust+from+rotational+hand-held+sanders.&rft.au=Hampl%2C+V%3BTopmiller%2C+J+L%3BWatkins%2C+D+S%3BMurdock%2C+D+J&rft.aulast=Hampl&rft.aufirst=V&rft.date=1992-01-01&rft.volume=7&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=APPL.+OCCUP.+ENVIRON.+HEALTH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; wood ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945343 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945338 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 6 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945288 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 6 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945286 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 1 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945283 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945257 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945246 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945236 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945235 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945203 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945197 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 6 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945191 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and the Epidemiology of Liver Cirrhosis AN - 1474334663 JF - Alcohol Health and Research World AU - Smart, Reginald G AU - Mann, Robert E Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 217 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+the+Epidemiology+of+Liver+Cirrhosis&rft.au=Smart%2C+Reginald+G%3BMann%2C+Robert+E&rft.aulast=Smart&rft.aufirst=Reginald&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism and Tuberculosis AN - 1474334564 JF - Alcohol Health and Research World AU - Jacobson, Jeffrey M Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 39 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism+and+Tuberculosis&rft.au=Jacobson%2C+Jeffrey+M&rft.aulast=Jacobson&rft.aufirst=Jeffrey&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism and Asymmetries of Brain Function AN - 1474334541 JF - Alcohol Health and Research World AU - Oscar-Berman, Marlene Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 273 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism+and+Asymmetries+of+Brain+Function&rft.au=Oscar-Berman%2C+Marlene&rft.aulast=Oscar-Berman&rft.aufirst=Marlene&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Instruction Manual for Making an Embryo: How Does Alcohol Affect Embryonic Development? AN - 1474334516 JF - Alcohol Health and Research World AU - Hogan, Brigid L M AU - Barnes, Joseph Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 324 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Instruction+Manual+for+Making+an+Embryo%3A+How+Does+Alcohol+Affect+Embryonic+Development%3F&rft.au=Hogan%2C+Brigid+L+M%3BBarnes%2C+Joseph&rft.aulast=Hogan&rft.aufirst=Brigid+L&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on Labor Market Success: Income, Earnings, Labor Supply, and Occupation AN - 1474334477 JF - Alcohol Health and Research World AU - Mullahy, John AU - Sindelar, Jody L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 134 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+Labor+Market+Success%3A+Income%2C+Earnings%2C+Labor+Supply%2C+and+Occupation&rft.au=Mullahy%2C+John%3BSindelar%2C+Jody+L&rft.aulast=Mullahy&rft.aufirst=John&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol-Related Chronic Disease AN - 1474334454 JF - Alcohol Health and Research World AU - Arria, Amelia M AU - THIEL, DAVID H. VAN Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 209 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol-Related+Chronic+Disease&rft.au=Arria%2C+Amelia+M%3BTHIEL%2C+DAVID+H.+VAN&rft.aulast=Arria&rft.aufirst=Amelia&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - A Description of Clients Using Employee Assistance Programs AN - 1474334448 JF - Alcohol Health and Research World AU - Blum, Terry C AU - Roman, Paul M Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 120 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=A+Description+of+Clients+Using+Employee+Assistance+Programs&rft.au=Blum%2C+Terry+C%3BRoman%2C+Paul+M&rft.aulast=Blum&rft.aufirst=Terry&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Immunity, Malnutrition, and Alcohol AN - 1474334372 JF - Alcohol Health and Research World AU - Mendenhall, Charles L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 23 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Immunity%2C+Malnutrition%2C+and+Alcohol&rft.au=Mendenhall%2C+Charles+L&rft.aulast=Mendenhall&rft.aufirst=Charles&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Expanding Boundaries of Alcohol Research AN - 1474334355 JF - Alcohol Health and Research World AU - Gordis, Enoch Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 255 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Expanding+Boundaries+of+Alcohol+Research&rft.au=Gordis%2C+Enoch&rft.aulast=Gordis&rft.aufirst=Enoch&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 31 Association of Alcohol Problems with Risk for AIDS in the 1988 National Health Interview Survey AN - 1474334336 JF - Alcohol Health and Research World AU - Stinson, Frederick S AU - Debakey, Samar F AU - Grant, Bridget F AU - Dawson, Deborah A Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 245 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+31+Association+of+Alcohol+Problems+with+Risk+for+AIDS+in+the+1988+National+Health+Interview+Survey&rft.au=Stinson%2C+Frederick+S%3BDebakey%2C+Samar+F%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Immune System: Mechanisms That Counteract Disease AN - 1474334321 JF - Alcohol Health and Research World AU - Grossman, Charles J AU - Wilson, Eve J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Immune+System%3A+Mechanisms+That+Counteract+Disease&rft.au=Grossman%2C+Charles+J%3BWilson%2C+Eve+J&rft.aulast=Grossman&rft.aufirst=Charles&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol, Memory, and Molecules AN - 1474321893 JF - Alcohol Health and Research World AU - Browning, Michael D AU - Hoffer, Barry J AU - Dunwiddie, Thomas V Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 280 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol%2C+Memory%2C+and+Molecules&rft.au=Browning%2C+Michael+D%3BHoffer%2C+Barry+J%3BDunwiddie%2C+Thomas+V&rft.aulast=Browning&rft.aufirst=Michael&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and the Immune System AN - 1474321844 JF - Alcohol Health and Research World AU - Roselle, Gary A Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 16 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+the+Immune+System&rft.au=Roselle%2C+Gary+A&rft.aulast=Roselle&rft.aufirst=Gary&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genomic Imprinting: Parental Origin Effects on Gene Expression AN - 1474321842 JF - Alcohol Health and Research World AU - Kirkness, Ewen F AU - Durcan, Michael J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 312 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genomic+Imprinting%3A+Parental+Origin+Effects+on+Gene+Expression&rft.au=Kirkness%2C+Ewen+F%3BDurcan%2C+Michael+J&rft.aulast=Kirkness&rft.aufirst=Ewen&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - General Glossary AN - 1474321825 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 46 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=General+Glossary&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Overview of Epidemiology with Applications to Alcohol Research AN - 1474321780 JF - Alcohol Health and Research World AU - Harford, Thomas C Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 177 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Overview+of+Epidemiology+with+Applications+to+Alcohol+Research&rft.au=Harford%2C+Thomas+C&rft.aulast=Harford&rft.aufirst=Thomas&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Latent Variable Modeling in Epidemiology AN - 1474321710 JF - Alcohol Health and Research World AU - MUTHÉN, BENGT O Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 286 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Latent+Variable+Modeling+in+Epidemiology&rft.au=MUTH%C3%89N%2C+BENGT+O&rft.aulast=MUTH%C3%89N&rft.aufirst=BENGT&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Effects of Prenatal Exposure to Alcohol AN - 1474321708 JF - Alcohol Health and Research World AU - Day, Nancy L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 238 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Effects+of+Prenatal+Exposure+to+Alcohol&rft.au=Day%2C+Nancy+L&rft.aulast=Day&rft.aufirst=Nancy&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Increased Behavioral Risk for AIDS AN - 1474321696 JF - Alcohol Health and Research World AU - Cooper, M Lynne Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 64 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Increased+Behavioral+Risk+for+AIDS&rft.au=Cooper%2C+M+Lynne&rft.aulast=Cooper&rft.aufirst=M&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol Consumption AN - 1474321639 JF - Alcohol Health and Research World AU - Midanik, Lorraine T AU - Room, Robin Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 183 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol+Consumption&rft.au=Midanik%2C+Lorraine+T%3BRoom%2C+Robin&rft.aulast=Midanik&rft.aufirst=Lorraine&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Abuse and Dependence from a Psychiatric Epidemiologic Perspective AN - 1474321506 JF - Alcohol Health and Research World AU - Bucholz, Kathleen K Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 197 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Abuse+and+Dependence+from+a+Psychiatric+Epidemiologic+Perspective&rft.au=Bucholz%2C+Kathleen+K&rft.aulast=Bucholz&rft.aufirst=Kathleen&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Potential Role of Alcohol in Human Immunodeficiency Virus Infection AN - 1474321491 JF - Alcohol Health and Research World AU - Kruger, Thomas E AU - Jerrells, Thomas R Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 57 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Potential+Role+of+Alcohol+in+Human+Immunodeficiency+Virus+Infection&rft.au=Kruger%2C+Thomas+E%3BJerrells%2C+Thomas+R&rft.aulast=Kruger&rft.aufirst=Thomas&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism Treatment for Employees and Family Members: Its Effect on Health Care Costs AN - 1474321477 JF - Alcohol Health and Research World AU - Holder, Harold D AU - Cunningham, Donald W Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 149 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism+Treatment+for+Employees+and+Family+Members%3A+Its+Effect+on+Health+Care+Costs&rft.au=Holder%2C+Harold+D%3BCunningham%2C+Donald+W&rft.aulast=Holder&rft.aufirst=Harold&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Molecular Modeling: Computer-Assisted Innovations in Drug Design - An Interview With Robert Pearlstein, Ph.D. AN - 1474321351 JF - Alcohol Health and Research World AU - Wilson, Eve J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 293 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Molecular+Modeling%3A+Computer-Assisted+Innovations+in+Drug+Design+-+An+Interview+With+Robert+Pearlstein%2C+Ph.D.&rft.au=Wilson%2C+Eve+J&rft.aulast=Wilson&rft.aufirst=Eve&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism: A Complex Genetic Disease AN - 1474321349 JF - Alcohol Health and Research World AU - Crabbe, John C AU - Goldman, David Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 297 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism%3A+A+Complex+Genetic+Disease&rft.au=Crabbe%2C+John+C%3BGoldman%2C+David&rft.aulast=Crabbe&rft.aufirst=John&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Consumption in Relation to Risk of Cancers of the Breast and Large Bowel AN - 1474321315 JF - Alcohol Health and Research World AU - Longnecker, Matthew P Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 223 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Consumption+in+Relation+to+Risk+of+Cancers+of+the+Breast+and+Large+Bowel&rft.au=Longnecker%2C+Matthew+P&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol-Related Trauma AN - 1474321194 JF - Alcohol Health and Research World AU - CHERPITEL, CHERYL J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 191 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol-Related+Trauma&rft.au=CHERPITEL%2C+CHERYL+J&rft.aulast=CHERPITEL&rft.aufirst=CHERYL&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 30 Prevalence of DSM - III - R Alcohol Abuse and/or Dependence Among Selected Occupations: United States, 1988 AN - 1474321186 JF - Alcohol Health and Research World AU - Stinson, Frederick S AU - Debakey, Samar Farha AU - Steffens, Rebecca A Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 165 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+30+Prevalence+of+DSM+-+III+-+R+Alcohol+Abuse+and%2For+Dependence+Among+Selected+Occupations%3A+United+States%2C+1988&rft.au=Stinson%2C+Frederick+S%3BDebakey%2C+Samar+Farha%3BSteffens%2C+Rebecca+A&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Job-Treatment Balance in Employee Assistance Programs AN - 1474317817 JF - Alcohol Health and Research World AU - Sonnenstuhl, William J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 129 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Job-Treatment+Balance+in+Employee+Assistance+Programs&rft.au=Sonnenstuhl%2C+William+J&rft.aulast=Sonnenstuhl&rft.aufirst=William&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Treating the Employed Alcoholic: Which Interventions Work? AN - 1474317800 JF - Alcohol Health and Research World AU - Walsh, Diana Chapman AU - Hingson, Ralph W AU - Merrigan, Daniel M AU - LEVENSON, SUZETTE MORELOCK Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 140 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Treating+the+Employed+Alcoholic%3A+Which+Interventions+Work%3F&rft.au=Walsh%2C+Diana+Chapman%3BHingson%2C+Ralph+W%3BMerrigan%2C+Daniel+M%3BLEVENSON%2C+SUZETTE+MORELOCK&rft.aulast=Walsh&rft.aufirst=Diana&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Drinking Patterns and Problems Among Women in Paid Employment AN - 1474317752 JF - Alcohol Health and Research World AU - Shore, Elsie R Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 160 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Drinking+Patterns+and+Problems+Among+Women+in+Paid+Employment&rft.au=Shore%2C+Elsie+R&rft.aulast=Shore&rft.aufirst=Elsie&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Gene Transfer and Gene Therapy AN - 1474317729 JF - Alcohol Health and Research World AU - Nielsen, David A AU - Goldman, David Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 304 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Gene+Transfer+and+Gene+Therapy&rft.au=Nielsen%2C+David+A%3BGoldman%2C+David&rft.aulast=Nielsen&rft.aufirst=David&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Retinoic Acid, Embryonic Development, and Alcohol-Induced Birth Defects AN - 1474317648 JF - Alcohol Health and Research World AU - Pullarkat, Raju K AU - Azar, Beth Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 317 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Retinoic+Acid%2C+Embryonic+Development%2C+and+Alcohol-Induced+Birth+Defects&rft.au=Pullarkat%2C+Raju+K%3BAzar%2C+Beth&rft.aulast=Pullarkat&rft.aufirst=Raju&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Reports Alcohol, Arrhythmia, and Sudden Death AN - 1474317605 JF - Alcohol Health and Research World AU - Friedman, Howard S Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 87 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Reports+Alcohol%2C+Arrhythmia%2C+and+Sudden+Death&rft.au=Friedman%2C+Howard+S&rft.aulast=Friedman&rft.aufirst=Howard&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Cancer AN - 1474317599 JF - Alcohol Health and Research World AU - Garro, Anthony J AU - Espina, Noel AU - Lieber, Charles S Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 81 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Cancer&rft.au=Garro%2C+Anthony+J%3BEspina%2C+Noel%3BLieber%2C+Charles+S&rft.aulast=Garro&rft.aufirst=Anthony&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Bacterial Pneumonia AN - 1474317573 JF - Alcohol Health and Research World AU - Nelson, Steve AU - Shellito, Judd AU - Mason, Carol AU - Summer, Warren R Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 73 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Bacterial+Pneumonia&rft.au=Nelson%2C+Steve%3BShellito%2C+Judd%3BMason%2C+Carol%3BSummer%2C+Warren+R&rft.aulast=Nelson&rft.aufirst=Steve&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - A Cultural Approach to Conceptualizing Alcohol and the Workplace AN - 1474317466 JF - Alcohol Health and Research World AU - Ames, Genevieve M AU - Janes, Craig Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 112 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=A+Cultural+Approach+to+Conceptualizing+Alcohol+and+the+Workplace&rft.au=Ames%2C+Genevieve+M%3BJanes%2C+Craig&rft.aulast=Ames&rft.aufirst=Genevieve&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - BEHAVIORAL SCIENCE: Decisions About Alcohol: Prevention, Intervention, and Policy AN - 1474317433 JF - Alcohol Health and Research World AU - Fischhoff, Baruch Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 257 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=BEHAVIORAL+SCIENCE%3A+Decisions+About+Alcohol%3A+Prevention%2C+Intervention%2C+and+Policy&rft.au=Fischhoff%2C+Baruch&rft.aulast=Fischhoff&rft.aufirst=Baruch&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The New Physics of Chaos: Can It Help Us Understand the Effects of Alcohol? AN - 1474317419 JF - Alcohol Health and Research World AU - Ehlers, Cindy L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 267 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+New+Physics+of+Chaos%3A+Can+It+Help+Us+Understand+the+Effects+of+Alcohol%3F&rft.au=Ehlers%2C+Cindy+L&rft.aulast=Ehlers&rft.aufirst=Cindy&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Viral Hepatitis and Alcoholism AN - 1474317306 JF - Alcohol Health and Research World AU - Rosman, Alan S Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 48 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Viral+Hepatitis+and+Alcoholism&rft.au=Rosman%2C+Alan+S&rft.aulast=Rosman&rft.aufirst=Alan&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Who Is Following the Recovering Alcoholic? Examining the Role of Followup in Employee Assistance Programs AN - 1474317097 JF - Alcohol Health and Research World AU - Erfurt, John C AU - Foote, Andrea Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 154 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Who+Is+Following+the+Recovering+Alcoholic%3F+Examining+the+Role+of+Followup+in+Employee+Assistance+Programs&rft.au=Erfurt%2C+John+C%3BFoote%2C+Andrea&rft.aulast=Erfurt&rft.aufirst=John&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Work-Related Risk Factors Associated with Alcohol Abuse AN - 1474317093 JF - Alcohol Health and Research World AU - Trice, Harrison M Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 106 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Work-Related+Risk+Factors+Associated+with+Alcohol+Abuse&rft.au=Trice%2C+Harrison+M&rft.aulast=Trice&rft.aufirst=Harrison&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol Consumption and Dependence Across Occupations in the United States AN - 1474316966 JF - Alcohol Health and Research World AU - Parker, Douglas A AU - Harford, Thomas C Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 97 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol+Consumption+and+Dependence+Across+Occupations+in+the+United+States&rft.au=Parker%2C+Douglas+A%3BHarford%2C+Thomas+C&rft.aulast=Parker&rft.aufirst=Douglas&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Fetal Alcohol Syndrome and Functioning of the Immune System AN - 1474316813 JF - Alcohol Health and Research World AU - Giberson, Pamela K AU - Weinberg, Joanne Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 29 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Fetal+Alcohol+Syndrome+and+Functioning+of+the+Immune+System&rft.au=Giberson%2C+Pamela+K%3BWeinberg%2C+Joanne&rft.aulast=Giberson&rft.aufirst=Pamela&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol-Related Interpersonal Violence AN - 1474316812 JF - Alcohol Health and Research World AU - Martin, Susan E Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 230 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol-Related+Interpersonal+Violence&rft.au=Martin%2C+Susan+E&rft.aulast=Martin&rft.aufirst=Susan&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Oxidative conversion of 6-fluorobenzo(c)phenanthrene to its K-region oxide by liver microsomes from 3-methylcholanthrene treated rats: reversal of stereoselectivity of cytochrome P-450c due to the influence of fluoro group. AN - 72583424; 1764102 AB - We have shown earlier that metabolism of carcinogenic 6-fluorobenzo(c)-phenanthrene by liver microsomes of 3-methylcholanthrene treated rats generate K-region oxide as the major metabolite, while no K-region oxide survives in benzo(c)-phenanthrene metabolism under identical conditions. To understand the influence of fluoro group on the generation of K-region oxide from this hydrocarbon, we have determined the enantiomeric composition and absolute configuration of the metabolic 6-fluorobenzo(c)phen-anthrene-7,8-oxide. Interestingly, the microsomal cytochrome P-450c forms predominantly the 5R,6S enantiomer from B(c)Ph, while it exhibits a reversal of stereoselectivity with 6-fluorobenzo(c)phenanthrene forming predominantly the 7S,8R enantiomer. We have attributed this observation to an unfavourable interaction of the fluoro group with the hydrophobic binding pocket of the isozyme. JF - Biochemical and biophysical research communications AU - Prasad, G K AU - Thakker, D R AD - Laboratory of Molecular Pharmacology, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/12/31/ PY - 1991 DA - 1991 Dec 31 SP - 1516 EP - 1523 VL - 181 IS - 3 SN - 0006-291X, 0006-291X KW - Carcinogens KW - 0 KW - Hydrocarbons, Fluorinated KW - Phenanthrenes KW - 6-fluorobenzo(c)phenanthrene KW - 34236-47-0 KW - Methylcholanthrene KW - 56-49-5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Rats KW - Animals KW - Biotransformation KW - Isomerism KW - Circular Dichroism KW - Male KW - Chromatography, High Pressure Liquid KW - Binding Sites KW - Phenanthrenes -- metabolism KW - Carcinogens -- metabolism KW - Methylcholanthrene -- pharmacology KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Hydrocarbons, Fluorinated -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72583424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Oxidative+conversion+of+6-fluorobenzo%28c%29phenanthrene+to+its+K-region+oxide+by+liver+microsomes+from+3-methylcholanthrene+treated+rats%3A+reversal+of+stereoselectivity+of+cytochrome+P-450c+due+to+the+influence+of+fluoro+group.&rft.au=Prasad%2C+G+K%3BThakker%2C+D+R&rft.aulast=Prasad&rft.aufirst=G&rft.date=1991-12-31&rft.volume=181&rft.issue=3&rft.spage=1516&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-07 N1 - Date created - 1992-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Communicating with patients about their medications. AN - 72461737; 1944456 JF - The New England journal of medicine AU - Kessler, D A AD - Food and Drug Administration, Rockville, MD 20857. Y1 - 1991/12/05/ PY - 1991 DA - 1991 Dec 05 SP - 1650 EP - 1652 VL - 325 IS - 23 SN - 0028-4793, 0028-4793 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Attitude of Health Personnel KW - Drug Information Services -- standards KW - Patient Compliance KW - Drug-Related Side Effects and Adverse Reactions KW - Pamphlets KW - Counseling -- standards KW - Drug Labeling -- standards KW - Patient Education as Topic -- methods KW - Communication KW - Pharmaceutical Services -- standards KW - Physician-Patient Relations KW - Drug Therapy -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Communicating+with+patients+about+their+medications.&rft.au=Kessler%2C+D+A&rft.aulast=Kessler&rft.aufirst=D&rft.date=1991-12-05&rft.volume=325&rft.issue=23&rft.spage=1650&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-11 N1 - Date created - 1991-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Principles and costs in the regulation of microbially contaminated foods. AN - 72751750; 1822932 AB - A strong code of regulations exists in the United States to control pathogens and other microbes in food and drink. Despite strict enforcement, food-borne illness persists. Parasitic animals in foods are particularly difficult to detect because there are no simple culture systems for their multiplication and because sanitary measures against fecal contamination are ineffective against parasite species transmitted by other routes. To attain a high degree of safety, total processing of foods by heat- and/or irradiation-pasteurization combined with sterile packaging may be required. The cost of regulating food-borne microbes, while large, is probably surpassed by the cost of food-borne illness (estimated to be US$50 billion annually), resulting in net savings. JF - The Southeast Asian journal of tropical medicine and public health AU - Jackson, G J AD - Division of Microbiology, US Food and Drug Administration, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 382 EP - 383 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Costs and Cost Analysis KW - Food Handling -- standards KW - Parasites -- isolation & purification KW - Legislation, Food -- economics KW - Parasitic Diseases -- prevention & control KW - Food Parasitology KW - Parasitic Diseases -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72751750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Principles+and+costs+in+the+regulation+of+microbially+contaminated+foods.&rft.au=Jackson%2C+G+J&rft.aulast=Jackson&rft.aufirst=G&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Testing for food-borne parasites, their metabolic products and symbionts. AN - 72749830; 1822919 AB - Microscopic animals associated with foods include free-living and saprophytic invertebrates, parasites of hosts other than humans, and parasitic animals specifically designated as food-borne that can infect a human host by the gastrointestinal route. The first general method used to screen for food-borne species was digestion with pepsin and hydrochloric acid at 36 degrees C, based on the "artificial stomach juice" technique for recovering larvae of the nematode Trichinella spiralis from muscle. This method selects for forms capable of surviving a mammalian digestive enzyme at mammalian temperatures. It has been used successfully to recover a variety of food-borne helminths, not only from mammalian flesh but also from fish, shellfish and molluscs, and can be adapted to greatly reduce the "background of living animals" associated with soils and the crops grown in them. However, not all animal forms that survive digestion are food-borne parasites, and all that succumb are not necessarily noninfectious. Methodology to test for food-borne parasites is, in general, not as efficient as that for food-borne bacteria. Recent developments in food parasitology indicate a need to identify not only the parasite, but also its metabolic products and associated symbionts. JF - The Southeast Asian journal of tropical medicine and public health AU - Jackson, G J AD - Division of Microbiology, United States Food and Drug Administration, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 334 EP - 336 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Pepsin A KW - EC 3.4.23.1 KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - Meat KW - Animals KW - Symbiosis KW - Humans KW - Fishes KW - Shellfish KW - Hydrochloric Acid -- metabolism KW - Pepsin A -- metabolism KW - Parasites -- metabolism KW - Parasites -- isolation & purification KW - Food Parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72749830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Testing+for+food-borne+parasites%2C+their+metabolic+products+and+symbionts.&rft.au=Jackson%2C+G+J&rft.aulast=Jackson&rft.aufirst=G&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isolation of parasites on fruits and vegetables. AN - 72749194; 1822873 AB - The current FDA method to recover parasites from fruits and vegetables is derived from procedures used to isolate parasitic protozoa from water. A 1kg portion of fruit or vegetable is divided into 200 g subportions. The subportions are sequentially processed in a sonic cleaning bath with 1.5 liters of detergent solution (1% sodium dodecyl sulfate, 0.1% Tween 80) and sonicated for 10 minutes. As each subsample is removed, it is thoroughly drained. After this sonic treatment, the wash water is collected in a polypropylene beaker, transferred to 50 ml polypropylene centrifuge tubes and centrifuged for 15 min at 1500 x g. The sediment is consolidated into one tube along with two rinsings of each tube. The final sediment is fixed in 4% formaldehyde for 10 minutes before examination for parasites. Indirect fluorescent antibody is applied to stain the parasites (Giardia spp. and/or Cryptosporidium spp.) by using commercial kits when available. If a large quantity of extraneous matter is contained in the sediment it may be reduced by layering on Sheather's fluid and centrifuging at 1500 x g for 15 minutes. The supernatant is collected and washed twice in distilled water. This procedure is adequate for protozoa and nonoperculate helminth eggs; operculate helminth eggs may be cleaned by extraction with ethyl acetate. When cabbage and lettuce were seeded at 1 organism/g, the rate of recovery for Cryptosporidium parvum with the FDA method was 1%. When cabbage was seeded at 1 egg/g and 10 eggs/g, the average rate of recovery of decorticated eggs of Ascaris sp. or untreated Trichuris sp. was 10%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Southeast Asian journal of tropical medicine and public health AU - Bier, J W AD - Division of Microbiology, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 144 EP - 145 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Index Medicus KW - Ascaris -- isolation & purification KW - Animals KW - Trichuris -- isolation & purification KW - Giardia -- isolation & purification KW - Cryptosporidium -- isolation & purification KW - Sonication KW - Brassica -- parasitology KW - Vegetables -- parasitology KW - Parasites -- isolation & purification KW - Food Parasitology KW - Fruit -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72749194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Isolation+of+parasites+on+fruits+and+vegetables.&rft.au=Bier%2C+J+W&rft.aulast=Bier&rft.aufirst=J&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Priority-based assessment of food additives database of the U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition. AN - 72746798; 1820284 AB - The priority-based assessment of food additives (PAFA) is a database maintained by the U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition. PAFA contains extensive administrative, chemical, and toxicological information on 1685 regulated direct food additives. The database also has limited administrative and chemical information on an additional 1236 direct additives. The total 2921 substances represent everything added to food in the United States. PAFA contains up to 150 different kinds of information about each chemical. Administrative and chemical information includes Chemical Abstracts Service Registry numbers, Code of Federal Regulations citations, the annual usage and estimated daily U.S. human consumption, the Joint Committee on Food Additives Allowable Daily Intakes, the FDA Redbook structure categories of the chemicals, and their technical effects. Toxicology information shows the type of studies done for each chemical, the species of animals tested, the toxicological effects observed and the sites where they were seen, the lowest doses that cause a toxicological effect in each study, a source citation, and other types of related information. JF - Environmental health perspectives AU - Benz, R D AU - Irausquin, H AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 85 EP - 89 VL - 96 SN - 0091-6765, 0091-6765 KW - Food Additives KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Administration, Oral KW - Animals KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - United States Food and Drug Administration KW - Food Additives -- chemistry KW - Databases, Factual KW - Food Additives -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72746798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Priority-based+assessment+of+food+additives+database+of+the+U.S.+Food+and+Drug+Administration+Center+for+Food+Safety+and+Applied+Nutrition.&rft.au=Benz%2C+R+D%3BIrausquin%2C+H&rft.aulast=Benz&rft.aufirst=R&rft.date=1991-12-01&rft.volume=96&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-04 N1 - Date created - 1992-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Regul Toxicol Pharmacol. 1984 Mar;4(1):37-56 [6718769] Regul Toxicol Pharmacol. 1987 Jun;7(2):160-8 [3303168] Regul Toxicol Pharmacol. 1986 Jun;6(2):181-91 [3726179] Regul Toxicol Pharmacol. 1985 Jun;5(2):152-74 [3839589] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of synergism/antagonism between HIV-1 antibody-positive human sera and soluble CD4 in blocking HIV-1 binding and infectivity. AN - 72713561; 1687500 AB - We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. This allows the assessment of synergism/antagonism at any desired level of effect. Using three assays (whole virus binding to CD4 cells, neutralization of HIV infectivity, and binding of purified gp120 to solid-phase sCD4), we generally observed additive effects or slight synergism between antibody and sCD4 in inhibiting gp120-CD4 interaction. We used a fourth assay to measure the irreversible inactivation of HIV infectivity by sCD4, a property that can also be mediated by antibody but with considerably less potency than sCD4. The reduction in HIV infectivity mediated by mixtures of sCD4 and antibody was always equal to or greater than the arithmetic sum of the reductions by either agent alone. The relevant antiviral effects of sCD4 and anti-HIV sera may include reversible blockage of receptor binding, irreversible inactivation of HIV infectivity, and in the case of antibody, additional reactions that are independent of receptor binding. Although predictions concerning the in vivo situation are speculative, we find no evidence in vitro for antagonism between sCD4 and antibody with respect to the net effect of the two in blocking HIV binding and infectivity. JF - AIDS research and human retroviruses AU - Kennedy, M S AU - Orloff, S AU - Ibegbu, C C AU - Odell, C D AU - Maddon, P J AU - McDougal, J S AD - Immunology Branch, Centers for Disease Control, U.S. Public Health Service, Atlanta GA 30333. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 975 EP - 981 VL - 7 IS - 12 SN - 0889-2229, 0889-2229 KW - Antigens, CD4 KW - 0 KW - HIV Antibodies KW - HIV Envelope Protein gp120 KW - Immune Sera KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Binding, Competitive KW - Neutralization Tests KW - Drug Synergism KW - Male KW - HIV-1 -- metabolism KW - HIV-1 -- immunology KW - HIV Antibodies -- immunology KW - Immune Sera -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV-1 -- physiology KW - CD4-Positive T-Lymphocytes -- microbiology KW - Antigens, CD4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72713561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=Analysis+of+synergism%2Fantagonism+between+HIV-1+antibody-positive+human+sera+and+soluble+CD4+in+blocking+HIV-1+binding+and+infectivity.&rft.au=Kennedy%2C+M+S%3BOrloff%2C+S%3BIbegbu%2C+C+C%3BOdell%2C+C+D%3BMaddon%2C+P+J%3BMcDougal%2C+J+S&rft.aulast=Kennedy&rft.aufirst=M&rft.date=1991-12-01&rft.volume=7&rft.issue=12&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-12 N1 - Date created - 1992-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Confirmation of oxytetracycline, tetracycline and chlortetracycline residues in milk by particle beam liquid chromatography/mass spectrometry. AN - 72707984; 1812989 AB - A method using particle beam liquid chromatography/mass spectrometry was developed for the confirmation of oxytetracycline, tetracycline and chlortetracycline residues in bovine milk. This method is one of the first to apply particle beam technology to the confirmation of animal drug residues in food products for regulatory purposes. The milk is centrifuged, using molecular weight cut-off filters to remove components of 25,000 daltons and above from the milk. The filtrate is passed through a C-18 sample preparation cartridge which retains the tetracyclines. After the columns are washed with water, the tetracyclines are eluted with 0.1 M oxalic acid in methanol and concentrated. The compounds are separated on a Novapak C-18 column with a methanol-oxalic acid-acetonitrile mobile phase. Negative chemical ionization with selective ion monitoring is used to identify the tetracyclines. The procedure was used to confirm the presence of each tetracycline at 100 ng ml-1 in fortified and incurred milk samples. JF - Biological mass spectrometry AU - Kijak, P J AU - Leadbetter, M G AU - Thomas, M H AU - Thompson, E A AD - Food and Drug Administration, Division of Veterinary Medical Research, Beltsville, Maryland 20705. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 789 EP - 795 VL - 20 IS - 12 SN - 1052-9306, 1052-9306 KW - Tetracycline KW - F8VB5M810T KW - Chlortetracycline KW - WCK1KIQ23Q KW - Oxytetracycline KW - X20I9EN955 KW - Index Medicus KW - Animals KW - Gas Chromatography-Mass Spectrometry -- methods KW - Drug Residues -- analysis KW - Chlortetracycline -- analysis KW - Tetracycline -- analysis KW - Milk -- analysis KW - Oxytetracycline -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72707984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+mass+spectrometry&rft.atitle=Confirmation+of+oxytetracycline%2C+tetracycline+and+chlortetracycline+residues+in+milk+by+particle+beam+liquid+chromatography%2Fmass+spectrometry.&rft.au=Kijak%2C+P+J%3BLeadbetter%2C+M+G%3BThomas%2C+M+H%3BThompson%2C+E+A&rft.aulast=Kijak&rft.aufirst=P&rft.date=1991-12-01&rft.volume=20&rft.issue=12&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Biological+mass+spectrometry&rft.issn=10529306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-12 N1 - Date created - 1992-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancing the quality of epidemiologic studies. AN - 72682814; 1800679 AB - Three principles can improve epidemiologic studies (1) Conduct open scientific review of research protocols and final reports, (2) Disseminate study results to all appropriate parties, and (3) Incorporate new scientific methods into the research and utilize expertise from other disciplines. The procedures we describe are used within the Industrywide Studies Branch of the National Institute for Occupational Safety and Health to implement these principles. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Fingerhut, M A AU - Halperin, W E AU - Okun, A H AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1233 EP - 1235 VL - 33 IS - 12 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - United States KW - Occupational Exposure KW - Humans KW - Peer Review KW - National Institute for Occupational Safety and Health (U.S.) KW - Clinical Protocols KW - Research Design -- trends KW - Epidemiologic Methods KW - Research Design -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72682814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Enhancing+the+quality+of+epidemiologic+studies.&rft.au=Fingerhut%2C+M+A%3BHalperin%2C+W+E%3BOkun%2C+A+H&rft.aulast=Fingerhut&rft.aufirst=M&rft.date=1991-12-01&rft.volume=33&rft.issue=12&rft.spage=1233&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-17 N1 - Date created - 1992-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of air for tertiary amine catalysts used in the polyurethane foam industry. AN - 72635555; 1781428 JF - American Industrial Hygiene Association journal AU - Foley, G D AU - Tucker, S P AU - Cooper, C V AD - National Institute for Occupational Safety and Health, Cincinnati, OH 44226. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - A664 EP - A665 VL - 52 IS - 12 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Ethyl Ethers KW - Morpholines KW - Piperazines KW - Polyurethanes KW - triethylenediamine KW - X8M57R0JS5 KW - Index Medicus KW - United States KW - Evaluation Studies as Topic KW - Humans KW - United States Occupational Safety and Health Administration KW - Air Pollutants, Occupational -- analysis KW - Ethyl Ethers -- analysis KW - Piperazines -- analysis KW - Morpholines -- analysis KW - Environmental Monitoring -- methods KW - Chemical Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72635555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Analysis+of+air+for+tertiary+amine+catalysts+used+in+the+polyurethane+foam+industry.&rft.au=Foley%2C+G+D%3BTucker%2C+S+P%3BCooper%2C+C+V&rft.aulast=Foley&rft.aufirst=G&rft.date=1991-12-01&rft.volume=52&rft.issue=12&rft.spage=A664&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-09 N1 - Date created - 1992-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Environmental study of firefighters. AN - 72614624; 1768008 AB - A study of firefighter exposures was undertaken at the request of the U.S. Fire Administration. This work was part of a larger study which included field evaluation of the performance of the self-contained breathing apparatus (SCBA) worn by firefighters during structural firefighting. Measurements were made for a variety of contaminants including CO, CO2, benzene, HCN, HCl, H2SO4, HF, acrolein, CH4, formaldehyde and PNAs. Many of the analyses were performed by collection of bag samples followed by Fourier transform infrared spectroscopy using a field mobile spectrometer. Measurements were also made using solid sorbent tubes and direct-reading meters. Sampling was done both during the knockdown and during overhaul phases of structural firefighting. Also, in order to estimate exposures including those when the SCBAs were worn, measurements were made both inside and outside the SCBA facepiece. Carbon monoxide was the most common contaminant found during knockdown, and about 10% of the samples were greater than 1500 ppm. Formaldehyde, acrolein, hydrogen chloride, hydrogen cyanide, sulphuric acid and hydrogen fluoride all exceeded their respective short-term exposure limits (STEL) on some occasions. Approximately 50% of the knockdown samples for acrolein exceeded the STEL. During overhaul, when masks were usually not worn, many of the contaminants found during knockdown were detected, but typically at much lower concentrations. Inside-mask sampling data suggest that exposure to low concentrations of a variety of compounds is occurring but this is believed to be principally the result of early mask removal or of non-use during knockdown rather than of leakage. The three basic sampling approaches (bag sampling, sorbent tubes and direct-reading meters) proved in this study to be complementary and served to maximize our ability to detect and quantify a wide range of combustion products. JF - The Annals of occupational hygiene AU - Jankovic, J AU - Jones, W AU - Burkhart, J AU - Noonan, G AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 581 EP - 602 VL - 35 IS - 6 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Spectrophotometry, Infrared KW - Evaluation Studies as Topic KW - Environmental Monitoring KW - Humans KW - Respiratory Protective Devices -- standards KW - Air Pollutants, Occupational -- analysis KW - Fires -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72614624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Environmental+study+of+firefighters.&rft.au=Jankovic%2C+J%3BJones%2C+W%3BBurkhart%2C+J%3BNoonan%2C+G&rft.aulast=Jankovic&rft.aufirst=J&rft.date=1991-12-01&rft.volume=35&rft.issue=6&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dietary exposure to furocoumarins. AN - 72613452; 1771268 AB - Natural furocoumarins, some of which are carcinogenic, are widespread components of the diet which are frequently consumed. Because of the paucity of samples, the wide scatter of analytical values, and other limitations in the data, only broad conclusions can be drawn. Most of the exposure is from limes, with smaller amounts coming from other citrus and umbelliferous food plants. The per capita exposure is estimated to be 1.3 mg per day. Exposure can be reduced through controlling stress in growing plants and stored food products. Because furocoumarins are one class of a large group of chemicals in a defensive system essential to plant survival, their total eradication is not possible. Further research is needed to assess their health risk. JF - Regulatory toxicology and pharmacology : RTP AU - Wagstaff, D J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 261 EP - 272 VL - 14 IS - 3 SN - 0273-2300, 0273-2300 KW - Furocoumarins KW - 0 KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Health Status Indicators KW - Aged, 80 and over KW - Adult KW - Environmental Exposure KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Food Contamination KW - Furocoumarins -- analysis KW - Furocoumarins -- adverse effects KW - Diet -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72613452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Dietary+exposure+to+furocoumarins.&rft.au=Wagstaff%2C+D+J&rft.aulast=Wagstaff&rft.aufirst=D&rft.date=1991-12-01&rft.volume=14&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish. AN - 72597398; 1765324 AB - The pharmacokinetics, tissue distribution and excretion of 14C-labelled aflatoxin B1 (AFB1) were examined after oral administration (250 micrograms/kg body weight) in channel catfish (Ictalurus punctatus). Plasma concentrations of parent AFB1 were best described by a one-compartment pharmacokinetic model, in which peak plasma concentration (503 ppb) occurred at 4.1 hr after dosing. The absorption and elimination half-lives were 1.5 and 3.7 hr, respectively. AFB1 was highly bound (95%) to plasma proteins. Concentrations of 14C (in AFB1 equivalents) measured in the tissues were highest at 4 hr, ranging from 596 ppb in the plasma to 40 ppb in the muscle. AFB1 residues were rapidly depleted; at 24 hr the concentrations in the plasma and muscle were 32 and less than 5 ppb, respectively. Concentrations in the bile exceeded 2000 ppb (at 24 hr), whereas the highest concentration in the urine was 51 ppb (4-6-hr collection interval). Renal and biliary excretion accounted for less than 5% of the administered dose, indicating incomplete absorption. Pharmacokinetic modelling and tissue data demonstrate a very low potential for the accumulation of AFB1 and its metabolites in the edible flesh of channel catfish through the consumption of AFB1-contaminated feed. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Plakas, S M AU - Loveland, P M AU - Bailey, G S AU - Blazer, V S AU - Wilson, G L AD - Division of Seafood Research, Food and Drug Administration, Dauphin Island, AL 36528. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 805 EP - 808 VL - 29 IS - 12 SN - 0278-6915, 0278-6915 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Administration, Oral KW - Animals KW - Ictaluridae KW - Scintillation Counting KW - Spectrophotometry, Ultraviolet KW - Tissue Distribution KW - Chromatography, High Pressure Liquid KW - Aflatoxin B1 -- urine KW - Aflatoxin B1 -- pharmacokinetics KW - Aflatoxin B1 -- blood KW - Aflatoxin B1 -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72597398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Tissue+disposition+and+excretion+of+14C-labelled+aflatoxin+B1+after+oral+administration+in+channel+catfish.&rft.au=Plakas%2C+S+M%3BLoveland%2C+P+M%3BBailey%2C+G+S%3BBlazer%2C+V+S%3BWilson%2C+G+L&rft.aulast=Plakas&rft.aufirst=S&rft.date=1991-12-01&rft.volume=29&rft.issue=12&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-20 N1 - Date created - 1992-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Considerations when measuring urinary albumin: precision, substances that may interfere, and conditions for sample storage. AN - 72596580; 1764788 AB - The measurement of small but abnormal amounts of albumin in urine is important in evaluating kidney disease in people with diabetes mellitus, hypertension, or possible adverse health effects from exposure to nephrotoxins. Routine laboratory methods for measuring albumin are not sensitive enough to measure the amounts that are significant in urine (less than 30 mg/L). In our laboratory we used three immunoassays for measuring urinary albumin: enzyme-linked immunosorbent assay (EIA), radioimmunoassay (RIA), and immunoturbidimetric assay (IT). We calculated the CVs of the three methods, investigated potential interfering substances at three times their normal concentrations, and stored urine under different conditions to find the best way to protect the sample until assay. The potential interferents we checked were transferrin, urea, beta 2-microglobulin, retinol-binding protein, creatinine, kappa and lambda light chains, IgG, hemoglobin, ketone, and glucose. The stability study involved two study temperatures (-20 and -70 degrees C) and four treatments (centrifuging or filtering, before or after storage). We found the following: the RIA had the lowest CV; the results from the interference study showed no interference from normal physiological concentrations of the substances investigated; storage at -70 degrees C regardless of the treatment should be adequate to prevent loss of albumin immunoreactivity. JF - Clinical chemistry AU - MacNeil, M L AU - Mueller, P W AU - Caudill, S P AU - Steinberg, K K AD - Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 2120 EP - 2123 VL - 37 IS - 12 SN - 0009-9147, 0009-9147 KW - Index Medicus KW - Radioimmunoassay -- standards KW - Nephelometry and Turbidimetry -- standards KW - Immunoenzyme Techniques -- standards KW - Humans KW - Preservation, Biological KW - Temperature KW - Time Factors KW - Quality Control KW - Albuminuria -- urine KW - Immunoassay -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72596580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Considerations+when+measuring+urinary+albumin%3A+precision%2C+substances+that+may+interfere%2C+and+conditions+for+sample+storage.&rft.au=MacNeil%2C+M+L%3BMueller%2C+P+W%3BCaudill%2C+S+P%3BSteinberg%2C+K+K&rft.aulast=MacNeil&rft.aufirst=M&rft.date=1991-12-01&rft.volume=37&rft.issue=12&rft.spage=2120&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions. AN - 72565733; 1747934 AB - Both nitroreduction and ring-oxidation appear to be important pathways for the in vivo metabolic activation of 1-nitropyrene (1-NP), a tumorigenic environmental contaminant. Previous studies, however, suggest that ring-oxidation is primarily responsible for the S9-mediated mutagenicity of 1-NP in Chinese hamster ovary (CHO) cells. In this study, an anaerobic rat liver S9 metabolizing system was used to facilitate the nitroreduction of 1-NP to a mutagen in repair-proficient CHO-K1-BH4 cells and excision-repair-deficient CHO-UV5 cells, and results using this system were compared with those obtained from the aerobic S9 metabolism of 1-NP. Anaerobic S9 metabolism of 2.5-15 micrograms/ml of 1-NP produced 15 +/- 3 mutants/10(6) cells/microgram 1-NP/ml with CHO-UV5 cells and 3 +/- 1 mutants/10(6) cells/microgram 1-NP/ml with CHO-K1-BH4 cells (different at P less than 0.001). When the assays were conducted with CHO-K1-BH4 cells, the number of mutants produced by 1-NP using aerobic treatment conditions was similar to that found using anaerobic conditions. In contrast, the aerobic incubations resulted in significantly fewer 1-NP-induced mutants than the anaerobic treatments when the assays were conducted with CHO-UV5 cells. Examination of the metabolites produced during these incubations indicated that under anaerobic conditions 1-NP was efficiently converted to 1-aminopyrene, while aerobic metabolism resulted in the formation of 1-NP phenols and dihydrodiols. DNA adduct analysis by 32P-postlabeling revealed that 1-NP treatment using the anaerobic procedure produced CHO-cell adducts by the reduction of 1-NP to N-hydroxy-1-aminopyrene, while aerobic incubations resulted in adducts produced by other metabolic pathways, probably involving ring-oxidation. These findings indicate that the S9-mediated metabolism of 1-NP under anaerobic conditions produces mutations and DNA adducts in CHO cells that are the result of nitroreductive metabolism. The results with aerobic S9 metabolism were consistent with the previous conclusion that this system mediated the mutagenicity of 1-NP in CHO cells mainly through the generation of ring-oxidized metabolites. The combination of the anaerobic and aerobic S9 metabolism procedures provides a new approach for evaluating the mutagenicity of nitropolycyclic aromatic hydrocarbons in mammalian cells. JF - Carcinogenesis AU - Thornton-Manning, J R AU - Smith, B A AU - Beland, F A AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 2317 EP - 2323 VL - 12 IS - 12 SN - 0143-3334, 0143-3334 KW - Liver Extracts KW - 0 KW - Mutagens KW - Pyrenes KW - DNA KW - 9007-49-2 KW - Oxygen KW - S88TT14065 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Mutagenicity Tests KW - Anaerobiosis -- physiology KW - Aerobiosis -- physiology KW - Oxygen -- metabolism KW - DNA -- metabolism KW - Cricetinae KW - CHO Cells -- metabolism KW - Mutagens -- metabolism KW - Pyrenes -- metabolism KW - Liver Extracts -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72565733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=S9-mediated+metabolism+of+1-nitropyrene+to+a+mutagen+in+Chinese+hamster+ovary+cells+by+ring-oxidation+under+aerobic+conditions+and+by+nitroreduction+under+anaerobic+conditions.&rft.au=Thornton-Manning%2C+J+R%3BSmith%2C+B+A%3BBeland%2C+F+A%3BHeflich%2C+R+H&rft.aulast=Thornton-Manning&rft.aufirst=J&rft.date=1991-12-01&rft.volume=12&rft.issue=12&rft.spage=2317&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-22 N1 - Date created - 1992-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Representativeness of deaths identified through the injury-at-work item on the death certificate: implications for surveillance. AN - 72543337; 1836109 AB - This research investigated the accuracy of the injury-at-work item on the death certificate for surveillance of occupational injury deaths in Oklahoma during 1985 and 1986. Representativeness of occupational injury deaths identified by death certificates was assessed by comparing these deaths with all occupational injury deaths identified through death certificates, workers' compensation reports, medical examiner reports, and OSHA records for categories of occupation, industry, and external causes of death. Certain external causes of death (e.g., motor vehicle traffic deaths) and certain occupations (e.g., farming) and industries (agriculture and services) are more often underidentified through death certificates. The findings of this study support Baker's observation that no single data source contains all deaths or all the data elements necessary to describe occupational injury deaths. Data sources may be combined to improve representativeness through more complete case ascertainment. JF - American journal of public health AU - Russell, J AU - Conroy, C AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WVa. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1613 EP - 1618 VL - 81 IS - 12 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Coroners and Medical Examiners -- statistics & numerical data KW - Humans KW - United States Occupational Safety and Health Administration -- statistics & numerical data KW - Databases, Factual -- standards KW - Cause of Death KW - Evaluation Studies as Topic KW - Industry -- statistics & numerical data KW - Occupations -- statistics & numerical data KW - Workers' Compensation -- statistics & numerical data KW - Medical Record Linkage -- standards KW - Female KW - Male KW - Oklahoma -- epidemiology KW - Death Certificates KW - Accidents, Occupational -- mortality KW - Wounds and Injuries -- mortality KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72543337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Representativeness+of+deaths+identified+through+the+injury-at-work+item+on+the+death+certificate%3A+implications+for+surveillance.&rft.au=Russell%2C+J%3BConroy%2C+C&rft.aulast=Russell&rft.aufirst=J&rft.date=1991-12-01&rft.volume=81&rft.issue=12&rft.spage=1613&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-16 N1 - Date created - 1992-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1988 Sep;78(9):1215-7 [3407824] Am J Public Health. 1976 Jul;66(7):649-54 [937611] J Occup Med. 1989 Oct;31(10):847-51 [2607383] J Occup Med. 1989 Apr;31(4):339-46 [2715840] World Health Stat Q. 1988;41(1):11-8 [3269210] J Occup Med. 1988 Nov;30(11):868-72 [3230433] Scand J Work Environ Health. 1988;14 Suppl 1:90-2 [3393894] N Z Med J. 1987 Jan 28;100(816):1-6 [3468389] Am J Public Health. 1987 Dec;77(12):1524-7 [3674251] Am J Public Health. 1987 Oct;77(10):1290-3 [3631362] Am J Public Health. 1987 Oct;77(10):1285-9 [3631361] J Occup Med. 1986 Feb;28(2):100-2 [3754006] Public Health Rep. 1985 May-Jun;100(3):329-33 [3923543] Public Health Rep. 1985 May-Jun;100(3):325-8 [3923542] Am J Epidemiol. 1990 Jan;131(1):132-42 [2403465] J Forensic Sci. 1990 Jul;35(4):932-7 [2391482] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Am J Public Health. 1990 Feb;80(2):198-200 [2297065] JAMA. 1982 Aug 13;248(6):692-7 [7097919] Am J Epidemiol. 1988 Oct;128(4):806-20 [3048086] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Update on breast implants. AN - 72532649; 1746397 JF - American family physician AU - Rheinstein, P H AU - Hoffman, F A AD - U.S. Food and Drug Administration, Rockville, Maryland. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 2227 EP - 2229 VL - 44 IS - 6 SN - 0002-838X, 0002-838X KW - Gels KW - 0 KW - Polyurethanes KW - Silicones KW - polyurethane foam KW - 9009-54-5 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Physicians, Family KW - Patient Education as Topic KW - Risk Factors KW - Humans KW - Physician's Role KW - Polyurethanes -- adverse effects KW - Female KW - United States Food and Drug Administration KW - Mammaplasty -- adverse effects KW - Silicones -- adverse effects KW - Prostheses and Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72532649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Update+on+breast+implants.&rft.au=Rheinstein%2C+P+H%3BHoffman%2C+F+A&rft.aulast=Rheinstein&rft.aufirst=P&rft.date=1991-12-01&rft.volume=44&rft.issue=6&rft.spage=2227&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - National Medical Expenditure Survey: health insurance, use of health services, and health care expenditures T2 - AHCPR pubn. no. 92-0017 Research findings 12 AN - 59597557; 1992-0612606 AB - Preliminary national estimates of personal, civilian health care use, and expenditures; findings from the 1987 Survey. JF - Nat Tech Info Service, December 1991. 18 pp. AU - Lefkowitz, D AU - Monheit, A Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 18 PB - Nat Tech Info Service KW - United States -- Medical sector KW - Medical service -- Costs -- United States KW - Health surveys -- United States KW - Medical service -- Costs KW - Health insurance -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59597557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lefkowitz%2C+D%3BMonheit%2C+A&rft.aulast=Lefkowitz&rft.aufirst=D&rft.date=1991-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=National+Medical+Expenditure+Survey%3A+health+insurance%2C+use+of+health+services%2C+and+health+care+expenditures&rft.title=National+Medical+Expenditure+Survey%3A+health+insurance%2C+use+of+health+services%2C+and+health+care+expenditures&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Nat Tech Info Service U.S. $17; elsewhere $34 N1 - Document feature - bibl(s), table(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Microbial indicators of sediment contamination in deepwater canyons of the continental shelf AN - 52678173; 1997-065680 JF - Eos, Transactions, American Geophysical Union AU - Small, E B AU - Cooper, R A AU - Gaines, J AU - Nerad, T AU - Sawyer, T AU - Anonymous Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 83 PB - American Geophysical Union, Washington, DC VL - 72 IS - 51, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - thallophytes KW - Lindenkohl Canyon KW - Block Canyon KW - Veatch Canyon KW - marine sediments KW - Hudson Canyon KW - sediments KW - Lydonia Canyon KW - Baltimore Canyon KW - Northwest Atlantic KW - Plantae KW - pollution KW - Eastern U.S. KW - submarine canyons KW - Munson Canyon KW - deep-water environment KW - Wilmington Canyon KW - bacteria KW - Toms Canyon KW - continental shelf KW - North Atlantic KW - Atlantic Ocean KW - microorganisms KW - 07:Oceanography KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52678173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Microbial+indicators+of+sediment+contamination+in+deepwater+canyons+of+the+continental+shelf&rft.au=Small%2C+E+B%3BCooper%2C+R+A%3BGaines%2C+J%3BNerad%2C+T%3BSawyer%2C+T%3BAnonymous&rft.aulast=Small&rft.aufirst=E&rft.date=1991-12-01&rft.volume=72&rft.issue=51%2C+Suppl.&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1992 ocean sciences meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; bacteria; Baltimore Canyon; Block Canyon; continental shelf; deep-water environment; Eastern U.S.; Hudson Canyon; Lindenkohl Canyon; Lydonia Canyon; marine sediments; microorganisms; Munson Canyon; North Atlantic; Northwest Atlantic; Plantae; pollution; sediments; submarine canyons; thallophytes; Toms Canyon; United States; Veatch Canyon; Wilmington Canyon ER - TY - JOUR T1 - Cytochrome P-450-dependent metabolism in alveolar type II epithelial cells: modulation by platelet-activating factor. AN - 72500512; 1958697 AB - Platelet-activating factor (PAF), an ether lipid mediator released from activated pulmonary phagocytes, was evaluated for its ability to affect cytochrome P-450-dependent activities in isolated rat alveolar type II cells. The data indicate that at non-toxic doses, PAF caused an increase in beta-naphthoflavone (BNF) inducible/alpha-naphthoflavone (ANF) sensitive ethoxyphenoxazone deethylase (EtOPx'ase) activity. At high concentrations of PAF, inhibition of both EtOPx'ase and metyrapone (MP) sensitive benzyloxyphenoxazone debenzylase (BzOPx'ase) activities and aggregation of type II cells were observed. The PAF analogs, lyso-PAF and enantio-PAF, exhibited actions similar to those observed with PAF. PAF-induced enhancement of EtOPx'ase activity required the presence of intact cells, whereas at high PAF concentrations decreased enzyme activities were observed in both intact cell and sonicated cell preparations. The data thus suggest that xenobiotic metabolism in alveolar type II cells can be modified by an inflammatory mediator, such as PAF, produced by alveolar phagocytes. JF - Biochimica et biophysica acta AU - Rabovsky, J AU - Pailes, W H AU - Judy, D J AU - Castranova, V AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505. Y1 - 1991/11/12/ PY - 1991 DA - 1991 Nov 12 SP - 223 EP - 229 VL - 1095 IS - 3 SN - 0006-3002, 0006-3002 KW - Platelet Activating Factor KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Oxidoreductases KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP2B1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Oxidoreductases -- metabolism KW - Cell Aggregation -- drug effects KW - In Vitro Techniques KW - Epithelium -- metabolism KW - Male KW - Structure-Activity Relationship KW - Mixed Function Oxygenases -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Platelet Activating Factor -- physiology KW - Platelet Activating Factor -- chemistry KW - Pulmonary Alveoli -- cytology KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72500512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Cytochrome+P-450-dependent+metabolism+in+alveolar+type+II+epithelial+cells%3A+modulation+by+platelet-activating+factor.&rft.au=Rabovsky%2C+J%3BPailes%2C+W+H%3BJudy%2C+D+J%3BCastranova%2C+V&rft.aulast=Rabovsky&rft.aufirst=J&rft.date=1991-11-12&rft.volume=1095&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-09 N1 - Date created - 1992-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of laboratory tests for immune biomarkers in environmental health studies concerned with exposure to indoor air pollutants. AN - 72758814; 1821385 AB - The immune system is likely to be involved in some of the health effects caused by certain indoor air exposures, and immune biomarkers can help determine which exposures and health effects have important immune components. However, the lack of standardized laboratory tests for most human immune markers and the many confounding variables that can influence them makes interpretation of results for exposure and disease end points uncertain. This paper presents an overview of the immune system and the considerations involved in using tests for immune markers in clinical epidemiology studies, particularly those concerned with indoor air exposures. Careful study design, well-characterized laboratory methods, and rigorous documentation of exposure status are required to determine the predictive value of such tests. Clinical tests currently available for some immune markers could help identify and characterize both irritative and hypersensitivity reactions to indoor air pollutants. Newer tests developed in research settings might provide more incisive indicators of immune status that could help identify exposure, susceptibility, or preclinical disease states, but their methodologies must be refined and tested in multicenter studies before they can be used reliably in public health applications. JF - Environmental health perspectives AU - Vogt, R F AD - Division of Environmental Health Laboratory Sciences, U.S. Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 85 EP - 91 VL - 95 SN - 0091-6765, 0091-6765 KW - Air Pollutants KW - 0 KW - Biomarkers KW - Index Medicus KW - Immunity, Cellular KW - Humans KW - Antibody Formation KW - Air Pollution, Indoor -- adverse effects KW - Environmental Monitoring -- standards KW - Immune System -- physiology KW - Immune System -- immunology KW - Air Pollutants -- adverse effects KW - Immunoassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72758814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Use+of+laboratory+tests+for+immune+biomarkers+in+environmental+health+studies+concerned+with+exposure+to+indoor+air+pollutants.&rft.au=Vogt%2C+R+F&rft.aulast=Vogt&rft.aufirst=R&rft.date=1991-11-01&rft.volume=95&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-20 N1 - Date created - 1992-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int Arch Allergy Appl Immunol. 1988;85(3):278-87 [3350607] Toxicol Ind Health. 1988 Dec;4(4):411-30 [3188041] Environ Res. 1987 Aug;43(2):290-307 [3608934] J Allergy Clin Immunol. 1987 Jun;79(6):919-27 [3584747] Allergy. 1986 Sep;41(7):520-5 [3789333] J Allergy Clin Immunol. 1986 Nov;78(5 Pt 2):1035-9 [3782664] N Engl Reg Allergy Proc. 1985 Spring;6(2):140-9 [3870494] N Engl Reg Allergy Proc. 1985 Spring;6(2):126-34 [3870492] N Engl J Med. 1990 Aug 9;323(6):357-65 [2370887] Am Rev Respir Dis. 1990 Sep;142(3):594-601 [2202248] Science. 1989 Jan 6;243(4887):83-5 [2911721] Annu Rev Pharmacol Toxicol. 1987;27:23-49 [3555316] Postgrad Med J. 1988;64 Suppl 4:111-9 [3076928] Int Arch Allergy Appl Immunol. 1987;82(3-4):238-43 [2437039] Cytometry. 1989 May;10(3):294-302 [2714113] Environ Res. 1989 Jun;49(1):7-19 [2721479] Cytometry. 1989 Jul;10(4):433-41 [2788566] J Allergy Clin Immunol. 1988 Oct;82(4):527-34 [3170998] J Allergy Clin Immunol. 1986 Apr;77(4):616-23 [2420853] J Allergy Clin Immunol. 1976 Jul;58(1 PT. 2):229-40 [783235] Br Med J. 1976 Apr 17;1(6015):936-8 [131592] J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):221-34 [7441082] J Reticuloendothel Soc. 1980 Dec;28(Suppl):61s-71s [6777492] Annu Rev Public Health. 1983;4:203-21 [6860438] J Allergy Clin Immunol. 1983 Dec;72(6):714-9 [6643876] Toxicology. 1990 Jan-Feb;60(1-2):15-25 [2315937] Scand J Work Environ Health. 1990 Apr;16(2):121-8 [2353195] Regul Toxicol Pharmacol. 1989 Feb;9(1):56-80 [2667038] J Allergy Clin Immunol. 1989 Oct;84(4 Pt 1):507-14 [2794294] Clin Immunol Immunopathol. 1989 Jul;52(1):3-9 [2785889] Arch Environ Health. 1990 Jul-Aug;45(4):217-23 [2400243] J Allergy Clin Immunol. 1990 Aug;86(2):177-81 [2384647] Biol Psychol. 1989 Feb;28(1):25-39 [2675991] Occup Med. 1987 Oct-Dec;2(4):669-81 [3313763] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in rats. AN - 72720349; 1666927 AB - THC is the major psychoactive constituent of marijuana and is known to produce psychopharmacological effects in humans. These studies were designed to determine whether acute or chronic exposure to marijuana smoke or THC produces in vitro or in vivo neurochemical alterations in rat or monkey brain. For the in vitro study, THC was added (1-100 nM) to membranes prepared from different regions of the rat brain and muscarinic cholinergic (MCh) receptor binding was measured. For the acute in vivo study, rats were injected IP with vehicle, 1, 3, 10, or 30 mg THC/kg and sacrificed 2 h later. For the chronic study, rats were gavaged with vehicle or 10 or 20 mg THC/kg daily, 5 days/week for 90 days and sacrificed either 24 h or 2 months later. Rhesus monkeys were exposed to the smoke of a single 2.6% THC cigarette once a day, 2 or 7 days a week for 1 year. Approximately 7 months after the last exposure, animals were sacrificed by overdose with pentobarbital for neurochemical analyses. In vitro exposure to THC produced a dose-dependent inhibition of MCh receptor binding in several brain areas. This inhibition of MCh receptor binding, however, was also observed with two other nonpsychoactive derivatives of marijuana, cannabidiol and cannabinol. In the rat in vivo study, we found no significant changes in MCh or other neurotransmitter receptor binding in hippocampus, frontal cortex or caudate nucleus after acute or chronic exposure to THC. In the monkey brain, we found no alterations in the concentration of neurotransmitters in caudate nucleus, frontal cortex, hypothalamus or brain stem.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Pharmacology, biochemistry, and behavior AU - Ali, S F AU - Newport, G D AU - Scallet, A C AU - Paule, M G AU - Bailey, J R AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 677 EP - 682 VL - 40 IS - 3 SN - 0091-3057, 0091-3057 KW - Biogenic Amines KW - 0 KW - Nerve Tissue Proteins KW - Receptors, Cholinergic KW - Cannabidiol KW - 19GBJ60SN5 KW - Serotonin KW - 333DO1RDJY KW - Dronabinol KW - 7J8897W37S KW - Cannabinol KW - 7UYP6MC9GH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Cannabinol -- toxicity KW - Cerebral Cortex -- drug effects KW - Cannabidiol -- pharmacology KW - Caudate Nucleus -- metabolism KW - Cerebral Cortex -- metabolism KW - Frontal Lobe -- drug effects KW - Hippocampus -- metabolism KW - Caudate Nucleus -- drug effects KW - Dopamine -- metabolism KW - Nerve Tissue Proteins -- biosynthesis KW - Hippocampus -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Biogenic Amines -- metabolism KW - Receptors, Cholinergic -- drug effects KW - Frontal Lobe -- metabolism KW - Macaca mulatta KW - Serotonin -- metabolism KW - Time Factors KW - Male KW - Brain Chemistry -- drug effects KW - Dronabinol -- blood KW - Dronabinol -- toxicity KW - Marijuana Smoking -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72720349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Chronic+marijuana+smoke+exposure+in+the+rhesus+monkey.+IV%3A+Neurochemical+effects+and+comparison+to+acute+and+chronic+exposure+to+delta-9-tetrahydrocannabinol+%28THC%29+in+rats.&rft.au=Ali%2C+S+F%3BNewport%2C+G+D%3BScallet%2C+A+C%3BPaule%2C+M+G%3BBailey%2C+J+R%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1991-11-01&rft.volume=40&rft.issue=3&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-14 N1 - Date created - 1992-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals. AN - 72716102; 1666926 AB - Several laboratories have reported that chronic exposure to delta-9-tetrahydrocannabinol (THC) or marijuana extracts persistently altered the structure and function of the rat hippocampus, a paleocortical brain region involved with learning and memory processes in both rats and humans. Certain choices must be made in designing experiments to evaluate cannabis neurotoxicity, such as dose, route of administration, duration of exposure, age at onset of exposure, species of subjects, whether or how long to allow withdrawal, and which endpoints or biomarkers of neurotoxicity to measure. A review of the literature suggests that both age during exposure and duration of exposure may be critical determinants of neurotoxicity. Cannabinoid administration for at least three months (8-10% of a rat's lifespan) was required to produce neurotoxic effects in peripubertal rodents, which would be comparable to about three years exposure in rhesus monkeys and seven to ten years in humans. Studies of monkeys after up to 12 months of daily exposure have not consistently reported neurotoxicity, and the results of longer exposures have not yet been studied. JF - Pharmacology, biochemistry, and behavior AU - Scallet, A C AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 671 EP - 676 VL - 40 IS - 3 SN - 0091-3057, 0091-3057 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Animals KW - Dronabinol -- toxicity KW - Cannabis KW - Nervous System Diseases -- physiopathology KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72716102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Neurotoxicology+of+cannabis+and+THC%3A+a+review+of+chronic+exposure+studies+in+animals.&rft.au=Scallet%2C+A+C&rft.aulast=Scallet&rft.aufirst=A&rft.date=1991-11-01&rft.volume=40&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-14 N1 - Date created - 1992-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The importance of employment status in occupational cohort mortality studies. AN - 72657974; 1790193 AB - Person-years at risk in occupational cohort mortality studies may be defined as "active" (when a person is working) or "inactive" (after a person has left employment at the plant under study). To investigate the effects of employment status (active/inactive) both across studies and within them, we have analyzed ten large cohort studies conducted by the National Institute for Occupational Safety and Health in which no occupational risk had been observed. These ten data sets included 89,376 workers, 1,984,505 person-years, and 18,840 deaths. In these ten studies, the SMR for all causes was positively correlated with the percentage of inactive person-years in the study (r = 0.57, p = 0.08). Considering only inactive person-years, the all-causes SMR was 1.12 (approximately 1.25 before age 65, dropping to 1.00 after age 65). Stratification of inactive person-years by time-since-last-employment showed markedly increased mortality during the first year following employment. The all-causes SMR during active person-years was 0.40 and was fairly constant across age categories. With active and inactive person-years combined, a strong negative trend in SMRs with duration of employment was observed for all causes and for heart disease. These trends were not apparent when person-years were stratified by employment status. These results indicate that investigators should evaluate the effects of employment status when comparing SMRs between multiple cohorts or when interpreting trends in rate ratios within cohorts. JF - Epidemiology (Cambridge, Mass.) AU - Steenland, K AU - Stayner, L AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratory, Cincinnati, OH 45226-1998. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 418 EP - 423 VL - 2 IS - 6 SN - 1044-3983, 1044-3983 KW - Index Medicus KW - Odds Ratio KW - Life Tables KW - Coronary Disease -- mortality KW - Neoplasms -- mortality KW - Risk Factors KW - Humans KW - Cohort Studies KW - Employment KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72657974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=The+importance+of+employment+status+in+occupational+cohort+mortality+studies.&rft.au=Steenland%2C+K%3BStayner%2C+L&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-11-01&rft.volume=2&rft.issue=6&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-31 N1 - Date created - 1992-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selecting exposure parameters in developmental neurotoxicity assessments. AN - 72623744; 1779944 AB - Numerous factors must be considered in selecting exposure parameters for developmental neurotoxicity investigations. Whether employing a single dose during pregnancy, or continuous exposure from prepregnancy through early postnatal developmental periods, the following primary factors should be addressed: 1) Purpose of the study; 2) pharmacokinetics/pharmacodynamics; 3) biotransformation; 4) genotypic variables; 5) limiting factors, including the availability of test compounds for evaluation; and, 6) several general, miscellaneous factors. Whether a single, large dose of an exogenous agent is more toxic to the developing nervous system than a series of smaller doses depends upon the interaction of the physicochemical, pharmacokinetic, and pharmacodynamic properties of the agent with the genotypic features of the test organism. JF - Neurotoxicology and teratology AU - Nelson, B K AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226. PY - 1991 SP - 569 EP - 573 VL - 13 IS - 6 SN - 0892-0362, 0892-0362 KW - Neurotoxins KW - 0 KW - Teratogens KW - Index Medicus KW - Animals KW - Biotransformation KW - Research Design KW - Female KW - Pregnancy KW - Teratogens -- metabolism KW - Neurotoxins -- metabolism KW - Neurotoxins -- pharmacokinetics KW - Teratogens -- pharmacokinetics KW - Aging -- drug effects KW - Nervous System -- drug effects KW - Nervous System -- embryology KW - Teratogens -- toxicity KW - Nervous System -- growth & development KW - Neurotoxins -- toxicity KW - Embryonic and Fetal Development -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72623744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Selecting+exposure+parameters+in+developmental+neurotoxicity+assessments.&rft.au=Nelson%2C+B+K&rft.aulast=Nelson&rft.aufirst=B&rft.date=1991-11-01&rft.volume=13&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-09 N1 - Date created - 1992-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of high doses of morphine on Con-A induced lymphokine production in vitro. AN - 72622773; 1663496 AB - Morphine, a potent analgesic drug as well as the active metabolite derived from heroin, has been reported to affect a variety of immune functions. In vivo administration of high doses of morphine to animals has been shown to inhibit natural killer (NK) cell activity in the rat (Shavit et al., 1984) and splenic T cell mitogenic response in the mouse (Bryant et al., 1988). We report here on the effect of morphine sulfate (MS) (0.2-1.6 mM) on Concanavalin-A (Con-A) stimulated lymphokine production by mouse splenocytes in vitro. Twenty-four hour incubation of mouse splenocytes with MS, removal of the drug and activation with Con-A resulted in a significant (linear regression, P less than 0.001) dose-related inhibition of lymphokine production (IC50 = 0.8 mM) as measured by bioassay for interleukin-2 (IL-2)/interleukin-4 (IL-4). The inhibitory effect of MS on lymphokine production was not blocked by opiate antagonists nor was the inhibitory effect mimicked by equivalent concentrations of mu, delta or epsilon receptor-specific opiate agonists. Exposure to the concentrations of MS used did not reduce viability of mouse splenocytes as determined by Trypan Blue exclusion. Morphine did not inhibit protein synthesis or adenylate cyclase activity in a T cell clone under identical conditions, indicating that MS, in this concentration range, does not simply interfere with all cell functions in a nonspecific manner. These results suggest that (1) morphine directly inhibits splenocyte function, (2) the inhibitory effect is not mediated through classical opiate receptors, and (3) the inhibitory effect is not due to toxicity. JF - Immunopharmacology AU - Jessop, J J AU - Taplits, M S AD - U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892. PY - 1991 SP - 175 EP - 184 VL - 22 IS - 3 SN - 0162-3109, 0162-3109 KW - Lymphokines KW - 0 KW - Receptors, Opioid KW - Concanavalin A KW - 11028-71-0 KW - Naloxone KW - 36B82AMQ7N KW - Morphine KW - 76I7G6D29C KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Protein Biosynthesis KW - Naloxone -- pharmacology KW - Cyclic AMP -- biosynthesis KW - Animals KW - T-Lymphocytes -- metabolism KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - T-Lymphocytes -- drug effects KW - Female KW - Receptors, Opioid -- physiology KW - Lymphokines -- biosynthesis KW - Morphine -- administration & dosage KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72622773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology&rft.atitle=Effect+of+high+doses+of+morphine+on+Con-A+induced+lymphokine+production+in+vitro.&rft.au=Jessop%2C+J+J%3BTaplits%2C+M+S&rft.aulast=Jessop&rft.aufirst=J&rft.date=1991-11-01&rft.volume=22&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology&rft.issn=01623109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-04 N1 - Date created - 1992-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phenytoin teratogenicity and midgestational pharmacokinetics in mice. AN - 72610504; 1771592 AB - Mice of the A/J and C57BL/6J (C57) strains were dosed with phenytoin (PHT) every 48 hr throughout pregnancy by gastric intubation to test the hypothesis that maternal plasma PHT concentration may be the significant factor in determining PHT reproductive and developmental toxicity. Serial serum samples were obtained from each mouse from gestation day (GD) 10-GD 12 for determination of individual dam PHT pharmacokinetics. Maximum PHT concentration and PHT AUC (area under-the-time-concentration curve) were regressed to laparotomy and fetal evaluation endpoints to determine whether significant association existed. Although serum PHT concentrations exceeded levels associated with teratogenicity (greater than 10 micrograms/ml), few major malformations were induced in either strain. However, in the A/J strain, there was a significant increased incidence of hydrocephaly and open eyelid. Regression of pharmacokinetic parameters with embryo and maternal endpoints indicated significant associations between gestational weight gain and maximum concentration measured (Cmax) or AUC in both strains. This association was also found for fetal weight in the C57 strain. In the A/J strain, the induction of decreased ossification of the sternebrae was also associated with maternal PHT concentration; however, linear regression of hydrocephaly and open eyelid to PHT concentration was not statistically significant. These results suggest that maternal plasma PHT concentration may be a quantifiable determinant of certain aspects of PHT developmental toxicity in the mouse. JF - Teratology AU - Roberts, L G AU - Laborde, J B AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 497 EP - 505 VL - 44 IS - 5 SN - 0040-3709, 0040-3709 KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Half-Life KW - Dose-Response Relationship, Drug KW - Gestational Age KW - Mice KW - Fetal Death -- chemically induced KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Phenytoin -- pharmacokinetics KW - Phenytoin -- toxicity KW - Phenytoin -- blood KW - Abnormalities, Drug-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72610504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Phenytoin+teratogenicity+and+midgestational+pharmacokinetics+in+mice.&rft.au=Roberts%2C+L+G%3BLaborde%2C+J+B%3BSlikker%2C+W&rft.aulast=Roberts&rft.aufirst=L&rft.date=1991-11-01&rft.volume=44&rft.issue=5&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypoglycemia associated hospitalizations in a population with a high prevalence of non-insulin-dependent diabetes mellitus. AN - 72578501; 1756685 AB - In order to evaluate the rates, causes, and clinical features of hospitalizations associated with hypoglycemia in a population with a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM), a retrospective analysis of medical records was conducted in a multi-hospital primary care system on the Navajo Indian Reservation. During an estimated 26,125 person-years of observation among diabetic patients, there were 126 hypoglycemia-associated admissions related to diabetes among 109 diabetic patients, yielding a hospitalization rate of 4.7 per 1000 person-years (95% CI 4.1-5.7). Using estimates of drug utilization based on a defined daily dose, hospitalization rates were 5.8 per 1000 PY (95% CI 4.4-7.6) for chlorpropamide, 16.0 per 1000 PY (95% CI 9.5-26.9) for glyburide, and 9.1 per 1000 PY (95% CI 6.9-11.9) for insulin. After stratification by age, the relative risk for hypoglycemia-associated hospitalization among patients prescribed glyburide compared to those prescribed chlorpropamide was 2.8 (95% CI 1.6-4.9). Hypoglycemia-associated hospitalizations were relatively common among patients with NIDDM, particularly among those treated with glyburide. JF - Diabetes research and clinical practice AU - Sugarman, J R AD - Indian Health Service Epidemiology Program, Seattle, Washington. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 139 EP - 147 VL - 14 IS - 2 SN - 0168-8227, 0168-8227 KW - Insulin KW - 0 KW - Glyburide KW - SX6K58TVWC KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - New Mexico -- epidemiology KW - Hospitalization KW - Arizona -- epidemiology KW - Humans KW - Utah -- epidemiology KW - Retrospective Studies KW - Prevalence KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Chlorpropamide -- adverse effects KW - Indians, North American KW - Glyburide -- adverse effects KW - Hypoglycemia -- mortality KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Hypoglycemia -- epidemiology KW - Hypoglycemia -- chemically induced KW - Insulin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72578501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+research+and+clinical+practice&rft.atitle=Hypoglycemia+associated+hospitalizations+in+a+population+with+a+high+prevalence+of+non-insulin-dependent+diabetes+mellitus.&rft.au=Sugarman%2C+J+R&rft.aulast=Sugarman&rft.aufirst=J&rft.date=1991-11-01&rft.volume=14&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Diabetes+research+and+clinical+practice&rft.issn=01688227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Separation and determination of diesel contaminants in various fish products by capillary gas chromatography. AN - 72568925; 1757424 AB - A semiquantitative capillary column gas chromatographic method is described for the determination of diesel fuel contamination in various canned seafood products. The diesel contaminants are separated from the fish sample by steam distillation, with little carry-over of interfering intrinsic materials such as fish oils. The diesel fuel is extracted from the condensate with n-hexane, and the extract is analyzed on an SPB-1 fused silica capillary column. The efficiency of recovery of diesel fuel added to canned seafood at levels of 40-400 ppt ranged from 72 to 102%. With the additional step of concentrating the hexane extract, the sensitivity of this procedure may be increased at least 10-fold. This procedure can detect the differences among diesel fuel grades No. 1, 2, and 5, and variations within diesel grade No. 2, and thus may be useful in determining the type of petroleum contaminants present in various canned fish products. JF - Journal - Association of Official Analytical Chemists AU - Newton, J M AU - Rothman, B S AU - Walker, F A AD - Food and Drug Administration, San Francisco, CA 94102. PY - 1991 SP - 986 EP - 990 VL - 74 IS - 6 SN - 0004-5756, 0004-5756 KW - Petroleum KW - 0 KW - Index Medicus KW - Petroleum -- analysis KW - Food Contamination KW - Fish Products -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72568925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Separation+and+determination+of+diesel+contaminants+in+various+fish+products+by+capillary+gas+chromatography.&rft.au=Newton%2C+J+M%3BRothman%2C+B+S%3BWalker%2C+F+A&rft.aulast=Newton&rft.aufirst=J&rft.date=1991-11-01&rft.volume=74&rft.issue=6&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of organochlorine pesticide residues using simultaneous injection of two capillary columns with electron capture and electrolytic conductivity detectors. AN - 72568895; 1757423 AB - A system has been developed that will allow low level screening of 31 organochlorine pesticide residues using simultaneous injection on 2 dissimilar capillary columns. An electron capture detector was attached to a DB-1701 column, and an electrolytic conductivity detector in the halogen mode was attached to a DB-5 column. Chlorinated pesticide amounts ranging from 0.05 ng for gamma-BHC to 1.5 ng for decamethrin can easily be quantitated and confirmed. The system can be used in either the column programmed mode or the isothermal column mode. Good reproducibility was obtained for injections in both modes. This system can easily be retrofitted to any gas chromatograph using on column or split/splitless injectors. JF - Journal - Association of Official Analytical Chemists AU - Hopper, M L AD - Food and Drug Administration, Total Diet Research Center, Kansas City, MO 64106. PY - 1991 SP - 974 EP - 981 VL - 74 IS - 6 SN - 0004-5756, 0004-5756 KW - Hydrocarbons, Chlorinated KW - 0 KW - Insecticides KW - Pesticide Residues KW - Index Medicus KW - Temperature KW - Chromatography, Gas -- instrumentation KW - Pesticide Residues -- analysis KW - Insecticides -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72568895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Analysis+of+organochlorine+pesticide+residues+using+simultaneous+injection+of+two+capillary+columns+with+electron+capture+and+electrolytic+conductivity+detectors.&rft.au=Hopper%2C+M+L&rft.aulast=Hopper&rft.aufirst=M&rft.date=1991-11-01&rft.volume=74&rft.issue=6&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bacillus stearothermophilus disk assay for determining ampicillin residues in fish muscle. AN - 72565332; 1757413 AB - The Bacillus stearothermophilus disk assay for penicillin in milk (AOAC official method) was adapted for the determination of ampicillin in fish muscle. The method was evaluated in 2 species of cultured fish: channel catfish and striped bass. Recoveries of ampicillin ranged from 99 to 104% when muscle specimens from both species were spiked at concentrations of 0.025-1.00 micrograms/g. The lower limit of determination (LOD) was 0.025 micrograms/g. The assay was applied to monitor the elimination of ampicillin from the muscle of striped bass after intravascular administration (dosage of 10 mg/kg body weight). The mean concentrations in the muscle declined from 1.160 micrograms/g at 2 h to 0.063 micrograms/g at 18 h. The half-life of ampicillin in the muscle was 3.6 h. Ampicillin concentrations were below LOD at 24 h. No inhibitory activity was observed in the muscle of control fish. JF - Journal - Association of Official Analytical Chemists AU - Plakas, S M AU - DePaola, A AU - Moxey, M B AD - Food and Drug Administration, Fishery Research Branch, Dauphin Island, AL 36528. PY - 1991 SP - 910 EP - 912 VL - 74 IS - 6 SN - 0004-5756, 0004-5756 KW - Ampicillin KW - 7C782967RD KW - Index Medicus KW - Animals KW - Muscles -- chemistry KW - Geobacillus stearothermophilus -- growth & development KW - Ictaluridae KW - Drug Residues -- analysis KW - Biological Assay KW - Ampicillin -- analysis KW - Geobacillus stearothermophilus -- drug effects KW - Ampicillin -- pharmacology KW - Bass KW - Ampicillin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72565332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Bacillus+stearothermophilus+disk+assay+for+determining+ampicillin+residues+in+fish+muscle.&rft.au=Plakas%2C+S+M%3BDePaola%2C+A%3BMoxey%2C+M+B&rft.aulast=Plakas&rft.aufirst=S&rft.date=1991-11-01&rft.volume=74&rft.issue=6&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Megestrol acetate in AIDS-related cachexia. AN - 72543995; 1746586 JF - American journal of hospital pharmacy AU - Mahayni, H AU - Minor, J R AD - Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, MD 20852. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 2479 EP - 2480 VL - 48 IS - 11 SN - 0002-9289, 0002-9289 KW - Megestrol KW - EA6LD1M70M KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Megestrol -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- complications KW - Cachexia -- drug therapy KW - Megestrol -- adverse effects KW - Megestrol -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72543995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hospital+pharmacy&rft.atitle=Megestrol+acetate+in+AIDS-related+cachexia.&rft.au=Mahayni%2C+H%3BMinor%2C+J+R&rft.aulast=Mahayni&rft.aufirst=H&rft.date=1991-11-01&rft.volume=48&rft.issue=11&rft.spage=2479&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hospital+pharmacy&rft.issn=00029289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Safety of ethoxyquin in dog foods. AN - 72458542; 1941216 JF - The Journal of nutrition AU - Dzanis, D A AD - Animal Feed Safety Branch, Food and Drug Administration, Rockville, MD 20857. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - S163 EP - S164 VL - 121 IS - 11 Suppl SN - 0022-3166, 0022-3166 KW - Ethoxyquin KW - 9T1410R4OR KW - Index Medicus KW - Animals KW - Dogs KW - Animal Feed -- adverse effects KW - Dog Diseases -- chemically induced KW - Ethoxyquin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72458542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Safety+of+ethoxyquin+in+dog+foods.&rft.au=Dzanis%2C+D+A&rft.aulast=Dzanis&rft.aufirst=D&rft.date=1991-11-01&rft.volume=121&rft.issue=11+Suppl&rft.spage=S163&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-25 N1 - Date created - 1991-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific binding of host cell proteins to the 3'-terminal stem-loop structure of rubella virus negative-strand RNA. AN - 72143390; 1920622 AB - At the 5' end of the rubella virus genomic RNA, there are sequences that can form a potentially stable stem-loop (SL) structure. The complementary negative-strand equivalent of the 5'-end SL structure of positive-strand rubella virus RNA [5' (+) SL structure] is thought to serve as a promoter for the initiation of positive-strand synthesis. We screened the negative-strand equivalent of the 5' (+) SL structure (64 nucleotides) and the adjacent region of the negative-strand RNA for their ability to bind to host cell proteins. Specific binding to the 64-nucleotide-long potential SL structure of three cytosolic proteins with relative molecular masses of 97, 79, and 56 kDa was observed by UV-induced covalent cross-linking. There was a significant increase in the binding of the 97-kDa protein from cells upon infection with rubella virus. Altering the SL structure by deleting sequences in either one of the two potential loops abolished the binding interaction. The 56-kDa protein also appeared to bind specifically to an SL derived from the 3' end of positive-strand RNA. The 3'-terminal structure of rubella virus negative-strand RNA shared the same protein-binding activity with similar structures in alphaviruses, such as Sindbis virus and eastern equine encephalitis virus. A possible role for the host proteins in the replication of rubella virus and alphaviruses is discussed. JF - Journal of virology AU - Nakhasi, H L AU - Cao, X Q AU - Rouault, T A AU - Liu, T Y AD - Division of Biochemistry and Biophysics, CBER, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 5961 EP - 5967 VL - 65 IS - 11 SN - 0022-538X, 0022-538X KW - Oligodeoxyribonucleotides KW - 0 KW - RNA, Viral KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Base Sequence KW - Models, Structural KW - Sindbis Virus -- genetics KW - Sequence Homology, Nucleic Acid KW - Molecular Sequence Data KW - Vero Cells KW - Protein Binding KW - Nucleic Acid Conformation KW - Molecular Weight KW - Transcription, Genetic KW - Rubella virus -- genetics KW - RNA, Viral -- isolation & purification KW - RNA, Viral -- genetics KW - RNA, Viral -- metabolism KW - Rubella virus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72143390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Specific+binding+of+host+cell+proteins+to+the+3%27-terminal+stem-loop+structure+of+rubella+virus+negative-strand+RNA.&rft.au=Nakhasi%2C+H+L%3BCao%2C+X+Q%3BRouault%2C+T+A%3BLiu%2C+T+Y&rft.aulast=Nakhasi&rft.aufirst=H&rft.date=1991-11-01&rft.volume=65&rft.issue=11&rft.spage=5961&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-14 N1 - Date created - 1991-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 1987 Sep;68 ( Pt 9):2347-57 [3655744] Proc Natl Acad Sci U S A. 1987 Jul;84(14):4811-5 [2440030] Nucleic Acids Res. 1987 Nov 11;15(21):8783-98 [3684574] J Gen Virol. 1988 Mar;69 ( Pt 3):603-12 [3351478] Gene. 1988;62(1):85-99 [2836271] Science. 1988 Sep 2;241(4870):1207-10 [3413484] Annu Rev Microbiol. 1988;42:657-83 [3060004] Science. 1989 Apr 21;244(4902):357-9 [2711187] Genes Dev. 1989 Apr;3(4):431-7 [2470643] Nucleic Acids Res. 1989 Jun 12;17(11):4393-4 [2740235] Gene. 1989 Oct 30;82(2):343-9 [2583526] J Virol. 1990 Apr;64(4):1465-76 [2319643] J Virol. 1990 Apr;64(4):1639-47 [2319648] Virology. 1990 Jul;177(1):225-38 [2353453] J Virol. 1990 Sep;64(9):4162-8 [2384916] Cell. 1990 Oct 19;63(2):369-80 [2170027] New Biol. 1990 Mar;2(3):255-64 [2279029] Science. 1991 Mar 29;251(5001):1597-600 [2011739] Nucleic Acids Res. 1981 Jan 10;9(1):133-48 [6163133] Arch Virol. 1982;72(1-2):47-54 [7103739] Virology. 1983 Apr 15;126(1):194-203 [6845655] J Virol. 1984 Feb;49(2):403-8 [6694262] Cell. 1986 Jan 17;44(1):137-45 [3753584] Virology. 1986 Oct 15;154(1):228-32 [3755848] J Biol Chem. 1986 Dec 15;261(35):16616-21 [3023358] Nucleic Acids Res. 1987 Apr 10;15(7):3041-57 [3562245] J Virol. 1988 Jan;62(1):47-53 [3334750] N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Child Health USA '91. AN - 62943969; ED345437 AB - This booklet summarizes recent information on the current health status and service needs of America's children. The booklet is intended to present sentinel health measures in a readily accessible and readable format to illustrate what has been accomplished for children and to identify what challenges remain. The booklet's four sections cover: general population data (population of children, children in poverty, family composition, working mothers, child care, and school dropouts); data for selected health status measures such as mortality, hospitalization, child abuse, and teenage sexuality, organized by developmental stages (infancy, childhood, and adolescence); information on health services utilization, such as health care financing, physician visits, hospital utilization by income, prenatal care, and immunization; and State-specific data on infant health, including mortality and prenatal care, low birth weight, and births to women under 18 years of age. (Approximately 40 references) (JDD) Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 113 VL - HRS-M-CH-91-1 KW - Service Utilization KW - ERIC, Resources in Education (RIE) KW - Demography KW - Health Services KW - Health Needs KW - Individual Characteristics KW - Child Health KW - Children KW - Physical Health KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62943969?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Photographs will not reproduce. N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Characterization of Iodine Derivatives of Aflatoxin B1 and G1 by Thermospray Mass Spectrometry AN - 1093460066; 17185288 AB - Thermospray mass spectrometry (TSMS) was used to identify the derivatives formed when iodine is reacted with aflatoxins B1 and G1 at approximately 70A?C to enhance fluorescence. It was found that stable derivatives were formed by addition of an iodine atom and a methoxy group across the double bond located on the furan ring of the aflatoxin B1 and G1 molecules. TSMS and TSMS/MS daughter spectra of the reaction products of aflatoxin B1 and G1 with iodine provide evidence of the addition of each moiety to produce the iodoa-'methoxy derivative. The addition of an iodine atom to one carbon and a methoxy group to the other carbon of the furan ring provided molecular weights of 470 and 486 for the products of aflatoxin B1 and G1, respectively. JF - Journal of Analytical Toxicology AU - Holcomb, Manuel AU - Korfmacher, Walter A AU - Thompson, Harold C AD - Department of Health and Human Services, Public Health Services, Food and Drug Administration, National Center for Toxicological Research, Office of Research Services, Division of Chemistry & Division of Biochemical Toxicology Jefferson, Arkansas 72079 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 289 EP - 292 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 15 IS - 6 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Aflatoxin B1 KW - Carbon KW - Fluorescence KW - Molecular weight KW - Iodine KW - Furans KW - Mass spectroscopy KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093460066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Characterization+of+Iodine+Derivatives+of+Aflatoxin+B1+and+G1+by+Thermospray+Mass+Spectrometry&rft.au=Holcomb%2C+Manuel%3BKorfmacher%2C+Walter+A%3BThompson%2C+Harold+C&rft.aulast=Holcomb&rft.aufirst=Manuel&rft.date=1991-11-01&rft.volume=15&rft.issue=6&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/1991/00000015/00000006/art00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Aflatoxin B1; Fluorescence; Carbon; Molecular weight; Iodine; Furans; Mass spectroscopy ER - TY - JOUR T1 - Methomyl in the Blood of a Pilot Who Crashed during Aerial Spraying AN - 1093455310; 17185298 AB - An aerial-spray pilot died when his aircraft crashed while he was spraying methomyl. We measured the pesticide in his blood by gas chromatography with flame photometric detection and confirmed the results by mass spectrometry with direct liquid injection through a liquid chromatography interface. The whole blood methomyl concentration was 570 ng/mL. JF - Journal of Analytical Toxicology AU - Driskell, William J AU - Groce, Don F AU - Hill, Robert H AU - Birky, Merritt M AD - Toxicology Branch, Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, 1600 Clifton Road, Public Health Service, U.S. Department of Health and Human Services, Atla Y1 - 1991/11// PY - 1991 DA - Nov 1991 SP - 339 EP - 340 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 15 IS - 6 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Aircraft KW - Blood KW - Blood levels KW - Gas chromatography KW - Liquid chromatography KW - Mass spectroscopy KW - Pesticides KW - Spraying KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093455310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Methomyl+in+the+Blood+of+a+Pilot+Who+Crashed+during+Aerial+Spraying&rft.au=Driskell%2C+William+J%3BGroce%2C+Don+F%3BHill%2C+Robert+H%3BBirky%2C+Merritt+M&rft.aulast=Driskell&rft.aufirst=William&rft.date=1991-11-01&rft.volume=15&rft.issue=6&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/1991/00000015/00000006/art00011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Blood; Aircraft; Liquid chromatography; Gas chromatography; Pesticides; Spraying; Mass spectroscopy; Blood levels ER - TY - JOUR T1 - Hearing loss in the chinchilla from impact and continuous noise exposure. AN - 85148699; pmid-1669963 AB - The relative hazard posed to the peripheral auditory system by impact/impulse and continuous noise of the same power spectrum was determined. Impact noise was generated by striking a nail with a hammer and was digitally recorded. The acoustical power spectrum of the impact was determined and pink noise was filtered to produce a continuous noise stimulus with the same acoustic power spectrum. Pre-exposure auditory evoked response (AER) thresholds were obtained at 1, 2, 4, and 8 kHz on 16 adult chinchillas. The pool of animals was divided into two equal groups based upon pre-exposure AER thresholds. One group was exposed to impact noise and the other group to the filtered pink noise. Exposures were 4 h/day for 5 days. Thirty days following the exposure, auditory evoked response thresholds were remeasured. Changes in auditory sensitivity were determined by subtracting the pre-exposure thresholds from the post-exposure thresholds. Hearing threshold shifts of the impact noise group were significantly greater (p less than 0.0001) than the hearing threshold shifts of the continuous noise group. These data indicate a need to more closely examine the parameters and effects of impact noise. There may be a need to develop expanded damage-risk criteria for occupational exposure to impulse/impact noise. JF - The Journal of the Acoustical Society of America AU - Dunn, D E AU - Davis, R R AU - Merry, C J AU - Franks, John Richard AD - U.S. Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.; Bioacoustics and Occupational Vibration Section, Physical Agents Effects Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.; Department of Speech and Hearing Science, College of Social and Behavioral Sciences, Colleges of the Arts and Sciences, Ohio State University PY - 1991 SP - 1979 EP - 1985 VL - 90 IS - 4 Pt 1 SN - 0001-4966, 0001-4966 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85148699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Hearing+loss+in+the+chinchilla+from+impact+and+continuous+noise+exposure.&rft.au=Dunn%2C+D+E%3BDavis%2C+R+R%3BMerry%2C+C+J%3BFranks%2C+John+Richard&rft.aulast=Dunn&rft.aufirst=D&rft.date=1991-10-01&rft.volume=90&rft.issue=4+Pt+1&rft.spage=1979&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Characterization of the mycotoxin fumonisin B1: comparison of thermospray, fast-atom bombardment and electrospray mass spectrometry. AN - 72760020; 1841646 AB - The utility of thermospray mass spectrometry (TSMS), fast-atom bombardment mass spectrometry (FABMS), and electrospray mass spectrometry (ESMS) for the analysis of Fumonisin B1 is investigated. In addition, the analysis of two different standards of Fumonisin B1 as well as an inoculated corn culture extract that contained Fumonisin B1 is reported. The results of these efforts show that ESMS, as well as FABMS and a combination of FAB and tandem mass spectrometry (FABMS/MS), provide useful data for the characterization of Fumonisin B1. The detection limit was 50 pg for Fumonisin B1 when analyzed by full scan FABMS, and 5 pg when analyzed by single-reaction monitoring FABMS/MS. JF - Rapid communications in mass spectrometry : RCM AU - Korfmacher, W A AU - Chiarelli, M P AU - Lay, J O AU - Bloom, J AU - Holcomb, M AU - McManus, K T AD - US FDA, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 463 EP - 468 VL - 5 IS - 10 SN - 0951-4198, 0951-4198 KW - Fumonisins KW - 0 KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Mass Spectrometry KW - Zea mays -- chemistry KW - Electrochemistry KW - Spectrometry, Mass, Fast Atom Bombardment KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72760020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Characterization+of+the+mycotoxin+fumonisin+B1%3A+comparison+of+thermospray%2C+fast-atom+bombardment+and+electrospray+mass+spectrometry.&rft.au=Korfmacher%2C+W+A%3BChiarelli%2C+M+P%3BLay%2C+J+O%3BBloom%2C+J%3BHolcomb%2C+M%3BMcManus%2C+K+T&rft.aulast=Korfmacher&rft.aufirst=W&rft.date=1991-10-01&rft.volume=5&rft.issue=10&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-23 N1 - Date created - 1992-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of the Mantel-Haenszel chi 2 overestimates precision in studies with sparse data. AN - 72566813; 1753307 AB - Probability values or "test-based" confidence limits computed on the basis of the Mantel-Haenszel chi 2 statistic may be invalid if minimum cell-size requirements are not met. In 30 studies of occupational proportionate mortality published from 1985 through 1987, the Mantel-Haenszel chi 2 was used in potential violation of cell-size requirements in 21 studies. Sixteen (76%) studies included at least one value that, when compared with testing with the Poisson distribution, was erroneously reported as statistically significant at the 0.05 level. We conclude that by using the Mantel-Haenszel chi 2 with sparse data, some epidemiologists overestimate precision. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - O'Brien, T R AU - Flanders, W D AU - Decoufle, P AD - Centers for Disease Control, Public Health Service, Atlanta, Ga 30333. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 1081 EP - 1083 VL - 33 IS - 10 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - Probability KW - Humans KW - Confidence Intervals KW - Bias (Epidemiology) KW - Data Interpretation, Statistical KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72566813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Use+of+the+Mantel-Haenszel+chi+2+overestimates+precision+in+studies+with+sparse+data.&rft.au=O%27Brien%2C+T+R%3BFlanders%2C+W+D%3BDecoufle%2C+P&rft.aulast=O%27Brien&rft.aufirst=T&rft.date=1991-10-01&rft.volume=33&rft.issue=10&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-29 N1 - Date created - 1992-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biologic basis for a risk assessment model for cleft palate. AN - 72502229; 1742301 AB - A biologic model for palatogenesis is presented, intended as a basis for risk assessment. It comprises a sequence of developmental stages: growth and migration of neural crest cells, downward growth of palatal buds, elevation of palatal shelves, and differentiation of the epithelium followed by shelf fusion. Several events representing these stages and amenable to mathematical translation may be measurable in the form of biomarkers such as DNA and protein synthesis, phospholipid metabolism, and signal transducing systems. Interrupting components of the model will result in cleft palate. Teratogens with known mechanisms of action are compared with the model. The quantitative risk of cleft palate is conceived as a sequence of mathematical probabilities that any stage of the model runs an abnormal course. Stage-specific probabilities are determined by a chemical's potency and dose, and by duration of exposure and gestational age. Species or strain sensitivity may be expressed as quantitative differences in model parameters. Although the model is designed for cleft palate, the risk model may also estimate a multiple response risk to the same exposures. JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association AU - Freni, S C AU - Zapisek, W F AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 338 EP - 346 VL - 28 IS - 4 SN - 1055-6656, 1055-6656 KW - Dentistry KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Cleft Palate -- chemically induced KW - Cleft Palate -- etiology KW - Cleft Palate -- embryology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72502229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Cleft+palate-craniofacial+journal+%3A+official+publication+of+the+American+Cleft+Palate-Craniofacial+Association&rft.atitle=Biologic+basis+for+a+risk+assessment+model+for+cleft+palate.&rft.au=Freni%2C+S+C%3BZapisek%2C+W+F&rft.aulast=Freni&rft.aufirst=S&rft.date=1991-10-01&rft.volume=28&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=The+Cleft+palate-craniofacial+journal+%3A+official+publication+of+the+American+Cleft+Palate-Craniofacial+Association&rft.issn=10556656&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-10 N1 - Date created - 1992-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of a simple weight-loss method for determining the permeation of organic liquids through rubber films. AN - 72485284; 1951056 AB - The standard ASTM method for determining permeation of liquid penetrants through polymeric films (F739-85) was compared with a simple weight-loss method. The weight-loss permeation cell was constructed of off-the-shelf components, a conventional analytical balance was used to measure the weight loss, and a chamber with continuous ventilation was used to hold the cell at constant temperature and evacuate the permeating penetrant. The advantages and limitations of the weight-loss method were illustrated by using data obtained from the permeation of acetonitrile, n-hexane, and methanol through films of four acrylonitrile-butadiene copolymers. The steady-state flux obtained by using the weight-loss method gave results statistically equivalent to the more analytically complex ASTM standard method. The weight-loss method required the experimenter to monitor the weight of the cell and its contents over time to obtain the steady-state flux whereas the ASTM method required the experimenter to chemically analyze for the penetrant concentration in the effluent gas stream as a function of time. The ASTM method required more analytical skill and training and more costly analytical equipment than did the simple weight-loss method. The weight-loss method needs further improvement and validation but shows promise even in its present form. By using the weight-loss method, the potential exists for far more chemical protective clothing users to conduct their own low-cost permeation testing as an initial screening to determine the relative permeation performance of candidate protective clothing materials. The weight-loss method is not meant to replace the standard ASTM method but to supplement it as a screening test. JF - American Industrial Hygiene Association journal AU - Mickelsen, R L AU - Hall, R C AU - Chern, R T AU - Myers, J R AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV 26505. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 445 EP - 447 VL - 52 IS - 10 SN - 0002-8894, 0002-8894 KW - Hazardous Substances KW - 0 KW - Polymers KW - Index Medicus KW - Evaluation Studies as Topic KW - Humans KW - Protective Clothing -- standards KW - Occupational Medicine -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72485284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Evaluation+of+a+simple+weight-loss+method+for+determining+the+permeation+of+organic+liquids+through+rubber+films.&rft.au=Mickelsen%2C+R+L%3BHall%2C+R+C%3BChern%2C+R+T%3BMyers%2C+J+R&rft.aulast=Mickelsen&rft.aufirst=R&rft.date=1991-10-01&rft.volume=52&rft.issue=10&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-19 N1 - Date created - 1991-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse behavioral reactions attributed to triazolam in the Food and Drug Administration's Spontaneous Reporting System. AN - 72159441; 1929688 AB - Reports of adverse behavioral reactions to triazolam, a triazolobenzodiazepine ultra-short-acting hypnotic, were examined in the postmarketing surveillance Spontaneous Reporting System of the Food and Drug Administration. Reports for triazolam of confusion, amnesia, bizarre behavior, agitation, and hallucinations were compared with reports of these reactions for temazepam, another short-acting hypnotic. Analysis of individual case reports from marketing through 1985 for triazolam vs temazepam showed 133 vs two for confusion, 109 vs three for amnesia, 59 vs two for bizarre behavior, 58 vs four for agitation, and 40 vs one for hallucinations. Considering extent of use, reporting rates for triazolam were 22 to 99 times those for temazepam, depending on the reaction. Reactions to triazolam tended to occur at higher doses and in older patients. This and an updated analysis of aggregate reports for the first 7 years of marketing of each drug with reporting rates and adjustment for various factors suggest a higher occurrence of these reactions with triazolam, but selection factors cannot be completely ruled out. When treating insomnia, physicians should emphasize sleep hygiene practices as alternatives to drug therapy; if drug therapy is required, they should prescribe hypnotics at the lowest recommended doses for the shortest clinically necessary durations and discontinue medication use should any adverse reactions occur. JF - Archives of internal medicine AU - Wysowski, D K AU - Barash, D AD - Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Md. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 2003 EP - 2008 VL - 151 IS - 10 SN - 0003-9926, 0003-9926 KW - Triazolam KW - 1HM943223R KW - Temazepam KW - CHB1QD2QSS KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Age Factors KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - United States Food and Drug Administration KW - Temazepam -- adverse effects KW - Product Surveillance, Postmarketing KW - Cognition Disorders -- chemically induced KW - Triazolam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72159441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Adverse+behavioral+reactions+attributed+to+triazolam+in+the+Food+and+Drug+Administration%27s+Spontaneous+Reporting+System.&rft.au=Wysowski%2C+D+K%3BBarash%2C+D&rft.aulast=Wysowski&rft.aufirst=D&rft.date=1991-10-01&rft.volume=151&rft.issue=10&rft.spage=2003&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1992 Jul;152(7):1527-9 [1627034] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of sequences within the murine granulocyte-macrophage colony-stimulating factor mRNA 3'-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cells. AN - 72132807; 1917935 AB - Phorbol esters (TPA) and concanavalin A (ConA) are known to induce granulocyte-macrophage colony-stimulating factor (GM-CSF) production in murine thymoma EL-4 cells by mRNA stabilization. The role of the 3'-untranslated region (3'-UTR) in GM-CSF mRNA stabilization induced by TPA and ConA in EL-4 cells was examined by transfection studies using chloramphenicol acetyltransferase (CAT) constructions. The GM-CSF 3'-UTR contains a 63-nucleotide region at its 3' end with repeating ATTTA motifs which is responsible for mRNA degradation in a variety of cell types (Shaw, G., and Kamen, R. (1986) Cell 46, 659-666). We produced constructs containing most of the GM-CSF 3'-UTR (303 nucleotides, pRSV-CATgm) or the 3'-terminal AT-rich region (116 nucleotides, pRSV-CATau) and measured CAT enzyme activity and CAT mRNA after transient transfection into EL-4 and NIH 3T3 cells. Low levels of CAT activity were seen in both cells with either plasmid compared with levels of CAT activity obtained with pRSV-CAT. TPA treatment caused an approximately 10-fold increase in CAT activity and mRNA in EL-4 cells transfected with pRSV-CATgm. No increases were seen in EL-4 cells transfected with pRSV-CATau or pRSV-CAT. No response to TPA was detected in transfected NIH 3T3 cells, indicating that the response to TPA is relatively cell-specific. There was no increase in CAT activity after ConA treatment in EL-4 or NIH 3T3 cells transfected with any of the constructs suggesting that the GM-CSF 3'-UTR lacks elements that can respond alone to ConA. Nuclear run-on and actinomycin D chase experiments in EL-4 cells showed that TPA induces CAT activity via mRNA stabilization. By linker-substitution mutagenesis we show that TPA inducibility depends on a 60-nucleotide region of the 3'-UTR whose 5' end is located 160 nucleotides upstream of the 5' end of the AU-rich region. JF - The Journal of biological chemistry AU - Iwai, Y AU - Bickel, M AU - Pluznik, D H AU - Cohen, R B AD - Division of Cytokine Biology, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/09/25/ PY - 1991 DA - 1991 Sep 25 SP - 17959 EP - 17965 VL - 266 IS - 27 SN - 0021-9258, 0021-9258 KW - DNA, Neoplasm KW - 0 KW - Mitogens KW - RNA, Messenger KW - RNA, Neoplasm KW - Concanavalin A KW - 11028-71-0 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Transcription, Genetic KW - Mice KW - RNA, Neoplasm -- genetics KW - Chloramphenicol O-Acetyltransferase -- metabolism KW - Plasmids KW - Mutagenesis KW - Base Sequence KW - Transfection KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - DNA, Neoplasm -- genetics KW - Protein Biosynthesis KW - Granulocyte-Macrophage Colony-Stimulating Factor -- genetics KW - Thymoma -- genetics KW - RNA, Messenger -- genetics KW - Thymoma -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72132807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+of+sequences+within+the+murine+granulocyte-macrophage+colony-stimulating+factor+mRNA+3%27-untranslated+region+that+mediate+mRNA+stabilization+induced+by+mitogen+treatment+of+EL-4+thymoma+cells.&rft.au=Iwai%2C+Y%3BBickel%2C+M%3BPluznik%2C+D+H%3BCohen%2C+R+B&rft.aulast=Iwai&rft.aufirst=Y&rft.date=1991-09-25&rft.volume=266&rft.issue=27&rft.spage=17959&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-29 N1 - Date created - 1991-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - HEALTH CARE FINANCING ADMINISTRATION CONSOLIDATION, BALTIMORE, MARYLAND. AN - 36394271; 3286 AB - PURPOSE: Consolidation of the offices and activities of the Health Care Financing Administration (HCFA) in Baltimore, Maryland is proposed. The HCFA, which is a section of the Department of Health and Human Services, currently employs 2,800 persons, who occupy nine buildings in the Woodlawn area of Baltimore County, Maryland. Based on project growth and current operational inefficiencies associated with this diffuse organization, HCFA needs to consolidate operations. As a result, the General Services Administration has been authorized to enter into a lease ownership selection process for approximately 664,100 occupiable square feet for a consolidated HCFA headquarters. A new HCFA site in the general Woodlawn area or in Baltimore City has also been authorized. Four locations are under consideration. One site is located in downtown Baltimore City; the site is bounded by Baltimore Street on the north, Greene Street on the west, Camden to Howard to Conway streets on the south, and Light and St. Paul streets on the east. Two other areas, located in Baltimore County, are adjacent to one another. One is in the Owings Mills area and the other in Woodlawn. The Owings Mills area is bounded by Route 695 to the east, proceeding northward to Route 795 to the Owings Mills Exit and Owings Mills Boulevard, traversing southeast to Lyons Mills Road to McDonogh Road to the northern side of Liberty Road. The Woodlawn area is defined as the area south of Liberty Road to Rolling Road, proceeding to Route 70; the area generally encompasses the zone between the current HCFA site and the Owings Mills location. The No Build alternative assumes that HCFA offices would remain in the present Woodlawn locations. POSITIVE IMPACTS: By centralizing HFCA operations, the new facility would increase the agency's efficiency and effectiveness. Regardless of the location of the facility, office vacancy rates would decline in the immediate area. In general, the area chosen for construction would experience a significant economic boost. NEGATIVE IMPACTS: Some portions of the Owings Mills area would be affected by the potential for subsidence, and both this area and the Woodlawn site could be subject to various forms of minor ground failure in the future. Development of the facility at either of the county sites would result in some degradation of surface water quality, increases in storm water runoff due to removal of vegetation and soil, reduction of groundwater recharge, displacement of wildlife habitat, and some conflicts with local land use patterns. The city site would lie partly within the Chesapeake Bay Critical Area. Both county sites would contain some floodplains. Placement of the facility at one of the county sites would involve more travel miles and vehicle trips than placement of the facility within the city. More land area would be needed for parking facilities at the county sites than at the city site. Any site would lie within a nonattainment area for ozone and particulate matter, and travel to and from the sites would contribute to these and other pollutant loadings. Daytime population increases would amount to 2.5 percent for the city and 20 to 22 percent for the county sites. Office vacancy rates in the areas of the existing decentralized facilities would increase significantly, and retail trade would decrease significantly upon consolidation at a single site. The potential for impacts to historic buildings or districts would be more likely in Owings Mills or downtown Baltimore than in Woodlawn. Utility hookups would be more difficult at the county sites than in the city. JF - EPA number: 910346, 434 pages and maps, September 23, 1991 PY - 1991 KW - Urban and Social Programs KW - Air Quality Standards Violations KW - Buildings KW - Central Business Districts KW - Employment KW - Floodplains KW - Historic Sites KW - Land Use KW - Leasing KW - Parking KW - Particulates KW - Subsidence KW - Traffic Analyses KW - Urban Development KW - Vegetation KW - Water Quality KW - Water Quality Assessments KW - Wildlife Habitat KW - Maryland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36394271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=HEALTH+CARE+FINANCING+ADMINISTRATION+CONSOLIDATION%2C+BALTIMORE%2C+MARYLAND.&rft.title=HEALTH+CARE+FINANCING+ADMINISTRATION+CONSOLIDATION%2C+BALTIMORE%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Public Buildings Service, Philadelphia, Pennsylvania; GSA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: September 23, 1991 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Occupational noise exposure and hearing loss in fire fighters assigned to airport fire stations. AN - 85244679; pmid-1781442 AB - The National Institute for Occupational Safety and Health (NIOSH) was requested to conduct a health hazard evaluation (HHE) at a large metropolitan fire department. The request concerned the hearing levels and noise exposures of fire fighters who were assigned to two fire stations serving the international airport. There was concern that these fire fighters were at a greater risk of accruing hearing loss than fire fighters located at other fire stations because of the addition of aircraft noise to their occupational noise exposures. The city also requested that NIOSH investigate other fire stations, not influenced by the airport, for noise exposures and hearing ability among a larger population of the fire fighters. NIOSH investigators conducted noise surveys at five fire stations and examined the hearing ability of 197 fire fighters. The noise surveys consisted of personal noise dosimetry on fire fighters assigned to the fire station for the entire 24-hr tour of duty over 2 consecutive days at each of the five stations. A NIOSH investigator accompanied the fire fighters on their vehicle to log response times and activities. The audiometric examinations were pure-tone, air conduction tests administered according to the Occupational Safety and Health Administration's (OSHA's) hearing conservation amendment. The noise dosimetry results revealed time-weighted averages (TWAs) that ranged from 60 to 82 dBA. However, the levels encountered during Code 3 responses (warning lights, sirens, and air horns) reached 109 dBA for a 1-min time period. The audiometric results showed that the average fire fighter exhibited a characteristic noise-induced permanent threshold shift.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American Industrial Hygiene Association Journal AU - Tubbs, R L AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH 45226. PY - 1991 SP - 372 EP - 378 VL - 52 IS - 9 SN - 0002-8894, 0002-8894 KW - Fires KW - Hearing Loss, Noise-Induced KW - Audiometry, Pure-Tone KW - Human KW - Adult KW - Hearing Tests KW - Middle Age KW - Time Factors KW - Male KW - Noise, Occupational KW - Occupational Exposure KW - Aircraft UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85244679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Occupational+noise+exposure+and+hearing+loss+in+fire+fighters+assigned+to+airport+fire+stations.&rft.au=Tubbs%2C+R+L&rft.aulast=Tubbs&rft.aufirst=R&rft.date=1991-09-01&rft.volume=52&rft.issue=9&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Gas chromatographic determination of captan, folpet, and captafol residues in tomatoes, cucumbers, and apples using a wide-bore capillary column: interlaboratory study. AN - 72647650; 1783591 AB - An interlaboratory study of the determination of captan, folpet, and captafol in tomatoes, cucumbers, and apples was conducted by 4 laboratories using wide-bore capillary column gas chromatography with electron capture detection. The 3 fungicides were determined using the Luke et al. multiresidue method modified to include additional solvent elution in the optional Florisil column cleanup step used with this method. The crops were fortified with each fungicide at 3 levels per crop. Mean recoveries ranged from 86.2% for a 25.1 ppm level of captan in apples to 115.4% for a 0.288 ppm level of captafol in apples. Interlaboratory coefficients of variation ranged from 3.4% (24.7 ppm folpet) to 9.7% (0.243 ppm captafol) for tomatoes; from 2.8% (2.0 ppm captafol) to 8.2% (24.8 ppm captan) for cucumbers; and from 1.5% (0.234 ppm folpet) to 22.1% (0.266 ppm captafol) for apples. JF - Journal - Association of Official Analytical Chemists AU - Gilvydis, D M AU - Walters, S M AD - Food and Drug Administration, Pesticides and Industrial Chemicals Research Center, Detroit, MI 48207. PY - 1991 SP - 830 EP - 835 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Cyclohexenes KW - 0 KW - Fungicides, Industrial KW - Pesticide Residues KW - Phthalimides KW - captafol KW - 2425-06-1 KW - Captan KW - EOL5G26Q9F KW - folpet KW - X5NFK36917 KW - Index Medicus KW - Chromatography, Gas -- instrumentation KW - Reproducibility of Results KW - Phthalimides -- analysis KW - Captan -- analogs & derivatives KW - Captan -- analysis KW - Vegetables -- chemistry KW - Fungicides, Industrial -- analysis KW - Pesticide Residues -- analysis KW - Fruit -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72647650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Gas+chromatographic+determination+of+captan%2C+folpet%2C+and+captafol+residues+in+tomatoes%2C+cucumbers%2C+and+apples+using+a+wide-bore+capillary+column%3A+interlaboratory+study.&rft.au=Gilvydis%2C+D+M%3BWalters%2C+S+M&rft.aulast=Gilvydis&rft.aufirst=D&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential inactivation of surrogate viruses with merocyanine 540. AN - 72644056; 1664526 AB - Bacteriophages may be useful as surrogates for animal viruses when the virucidal properties of different photosensitizing compounds are initially investigated. We studied photoinactivation of four bacteriophages, phi X174, T7, PRD1, and phi 6, by the dye merocyanine 540 (MC540) (15 micrograms/mL). Merocyanine 540 (MC540) should be most effective with lipid-containing viruses, since it is primarily lipophilic (but also binds to proteins). Two of the phages, PRD1 and phi 6 contain lipid, with only phi 6 having an external lipoprotein envelope. Filtered radiation (450-600 nm) from a 750 W projector was used at 16-100 W/m2. The survival curves of the different viruses clearly demonstrated different levels of sensitivity to photoinactivation by MC540, with phi 6 (Do = 1.5 kJ/m2) being the most sensitive, followed by T7 (21-fold less sensitive). While both PRD1 and phi 6 have lipid components, only phi 6 was photoinactivated by MC540. Thus the internal lipid components of PRD1 were not sufficient to allow photoinactivation by this dye, at fluences up to 300 kJ/m2. For comparison, we also photoinactivated Herpes simplex virus (Do = 0.053 kJ/m2) and found it to be 28-fold more sensitive than phi 6 to photoinactivation by the same concentration of MC540. Thus phi 6 may be used as a surrogate for enveloped human viruses for photoinactivation by lipophilic dyes, but the results may only be useful qualitatively. JF - Photochemistry and photobiology AU - Lytle, C D AU - Budacz, A P AU - Keville, E AU - Miller, S A AU - Prodouz, K N AD - Center for Devices and Radiological Health, FDA, Rockville, MD 20857. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 489 EP - 493 VL - 54 IS - 3 SN - 0031-8655, 0031-8655 KW - Antiviral Agents KW - 0 KW - Pyrimidinones KW - Radiation-Sensitizing Agents KW - merocyanine dye KW - 58823-12-4 KW - Index Medicus KW - Animals KW - Light KW - Dose-Response Relationship, Radiation KW - Cell Line KW - Simplexvirus -- drug effects KW - Bacteriophages -- growth & development KW - Radiation-Sensitizing Agents -- pharmacology KW - Antiviral Agents -- pharmacology KW - Pyrimidinones -- pharmacology KW - Simplexvirus -- growth & development KW - Bacteriophages -- radiation effects KW - Simplexvirus -- radiation effects KW - Bacteriophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72644056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Differential+inactivation+of+surrogate+viruses+with+merocyanine+540.&rft.au=Lytle%2C+C+D%3BBudacz%2C+A+P%3BKeville%2C+E%3BMiller%2C+S+A%3BProdouz%2C+K+N&rft.aulast=Lytle&rft.aufirst=C&rft.date=1991-09-01&rft.volume=54&rft.issue=3&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-13 N1 - Date created - 1992-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Time required to achieve homogeneity of test substances added to dog feed. AN - 72643869; 1783593 AB - The homogeneity of test substances in a carrier (animal feed) is a critical factor in conducting long-term feeding studies in laboratory animals. A method for determining the adequate amount of mixing to achieve homogeneity by a mixer of the type described has been determined when 2 distinctly different compounds are added to ground dog feed. Nicotinic acid and butylated hydroxyanisole at a concentration of 1% were separately mixed with the dog feed for 15, 30, 45, 60, and 120 min to determine optimum mixing time. Test portions were taken from 4 different sampling sites at each time period and analyzed in duplicate for the added substance. Four batches were prepared and the results were aggregated. Very little interbatch variability was observed. The variance of the average values from the 4 sampling sites at each time period was calculated and used as a simple, crude, but effective numerical quantity to monitor the approach to homogeneity of the mixture. JF - Journal - Association of Official Analytical Chemists AU - Sapienza, P P AU - Ikeda, G J AU - Warr, P I AU - Albert, R H AD - Food and Drug Administration, Division of Toxicological Studies, Beltsville Research Facility, MD 20705. PY - 1991 SP - 857 EP - 861 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Butylated Hydroxyanisole KW - 25013-16-5 KW - Niacin KW - 2679MF687A KW - Index Medicus KW - Butylated Hydroxyanisole -- analysis KW - Niacin -- analysis KW - Spectrophotometry, Ultraviolet KW - Chromatography, Liquid KW - Toxicology -- methods KW - Time Factors KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72643869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Time+required+to+achieve+homogeneity+of+test+substances+added+to+dog+feed.&rft.au=Sapienza%2C+P+P%3BIkeda%2C+G+J%3BWarr%2C+P+I%3BAlbert%2C+R+H&rft.aulast=Sapienza&rft.aufirst=P&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Performance characteristics of methods of analysis used for regulatory purposes. Part II. Pesticide formulations. AN - 72643740; 1783583 AB - The precision parameters of the method-performance (collaborative) studies published in the AOAC Journal from 1915 through 1990 for pesticide formulations have been recalculated on a uniform basis by the International Union of Pure and Applied Chemistry 1987 protocol. About 93% of the 953 accepted assays, which are predominantly gravimetric (G), volumetric (V), and gas (GC) and liquid (LC) chromatographic methods, exhibit relative standard deviations among laboratories (RSDR) that are generally less than 2 times the values predicted from the Horwitz equation: RSDR (%) = 2 exp (1-0.5 log C), where C is the concentration expressed as a decimal fraction. UV, VIS, and IR spectrophotometric (S) methods are somewhat poorer, with about 80% of the reported RSDR values less than twice the predicted RSDR value. The precision parameters of pesticide formulations analyzed by the older methods (G, V, GC) are equivalent to those previously found for drug preparations in the same concentration range; the precision parameters of pesticide formulations analyzed by LC and S are somewhat poorer. Overall, however, the precision parameters of pesticide formulations are generally independent of analyte, method, and matrix, and are primarily a function of concentration. The method-acceptability decisions of the AOAC for pesticide formulations during the past 75 years can be approximated retrospectively by using a criterion for RSDR that is less than 2 times the RSDR calculated from the Horwitz equation. JF - Journal - Association of Official Analytical Chemists AU - Horwitz, W AU - Albert, R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. PY - 1991 SP - 718 EP - 744 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Pesticides KW - 0 KW - Index Medicus KW - Reproducibility of Results KW - Methods KW - Databases, Factual KW - International Agencies KW - Pesticides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72643740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Performance+characteristics+of+methods+of+analysis+used+for+regulatory+purposes.+Part+II.+Pesticide+formulations.&rft.au=Horwitz%2C+W%3BAlbert%2C+R&rft.aulast=Horwitz&rft.aufirst=W&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - FDA monitoring program. Residues in foods--1990. AN - 72641806; 1783581 AB - In 1990, under regulatory monitoring, a total of 19,962 samples of domestically produced food from all 50 states and Puerto Rico and imported food from 92 countries were analyzed by FDA for pesticide residues. Of these, 19,146 were surveillance samples, which are collected when there is no suspicion of a pesticide problem. No residues were found in 60% of domestic surveillance samples and in 64% of import surveillance samples. Of the 19,146 surveillance samples, 2.8% were violative. Under the incidence/level aspect of monitoring, 172 samples of fish/shell-fish, 330 samples of whole milk, and 3502 samples of processed foods including baby foods were analyzed for pesticide residues. Findings from these projects were consistent with regulatory monitoring data. The findings of the 1990 Total Diet Study are evidence that actual dietary intakes of pesticides are generally well below the standards established by FAO/WHO and by EPA. The 1990 results are similar to those obtained in earlier years and demonstrate the continuing safety of the food supply relative to pesticide residues. JF - Journal - Association of Official Analytical Chemists AU - Yess, N J AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 121A EP - 141A VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - State Government KW - International Cooperation KW - Fishes KW - Food-Processing Industry -- standards KW - Animal Feed -- analysis KW - Meat -- analysis KW - Milk -- analysis KW - Food Analysis -- standards KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72641806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=FDA+monitoring+program.+Residues+in+foods--1990.&rft.au=Yess%2C+N+J&rft.aulast=Yess&rft.aufirst=N&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=121A&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Computation of the initially unknown boundaries of flow fields generated by local exhaust hoods. AN - 72639816; 1838234 AB - Local exhaust hoods are important in controlling contaminants in the workplace. To predict hood effectiveness, it is important to have knowledge of the airflow field that it generates. Currently, there are theoretical models adequate for predicting the flow fields of hoods with flanged openings. These models are solutions of Laplace's equation in terms of the velocity potential. Comparison of experimental and theoretical values of air velocities show good agreement. With the exception of the plain slot, no such models are available for plain hoods or other hoods with complex geometries. This paper explores the feasibility of approximating the equal air velocity contours for any local exhaust hood by assuming that these contours are also equipotential contours. A slot configuration, for which an analytical model is available, was used to evaluate the accuracy of the assumption. Starting with a good approximation for the 15% velocity contour, three other boundaries were generated. The procedure used in generating boundaries after the initial one involved solution of Laplace's equation, assuming constant potential along the boundary and adjustment of boundary location on the basis of differences between the calculated value of the normal derivative of the velocity potential at a point on the boundary and the specified value (15%). The next-to-last boundary generated by the procedure exhibited an oscillation in the values of the normal derivative, which was detrimental to the desired solution. Possible causes for this oscillation and possible refinements in the procedure are discussed. JF - American Industrial Hygiene Association journal AU - Anastas, M Y AD - National Institute for Occupational Safety and Health, Cincinnati OH 45226. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 379 EP - 386 VL - 52 IS - 9 SN - 0002-8894, 0002-8894 KW - Index Medicus KW - Rheology KW - Models, Theoretical KW - Environmental Monitoring KW - Air Pollution -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72639816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Computation+of+the+initially+unknown+boundaries+of+flow+fields+generated+by+local+exhaust+hoods.&rft.au=Anastas%2C+M+Y&rft.aulast=Anastas&rft.aufirst=M&rft.date=1991-09-01&rft.volume=52&rft.issue=9&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Efficiency of two commercial ELISA kits compared with the BAM culture method for detecting Listeria in naturally contaminated foods. AN - 72637836; 1783588 AB - The efficiency of 2 commercial enzyme-linked immunosorbent assay (ELISA) kits (Listeria-Tek and Tecra) for detecting Listeria in naturally contaminated foods was evaluated and compared with that of the culture method described in the Bacteriological Analytical Manual (BAM). Both ELISAs use modified University of Vermont (UVM-1) medium as a primary enrichment; the BAM method uses Listeria enrichment broth. Secondary enrichments for Listeria-Tek and Tecra, respectively, were Fraser broth and UVM-2, which contains additional acriflavin-HCl. When ELISA test results differed, secondary enrichments were tested against the other ELISA; Fraser broth was used to determine recovery rates because of its superiority over UVM-2. Of the 178 food samples examined, the presence of Listeria was detected and culturally confirmed in 38, 37, and 40 samples by the BAM, Listeria-Tek, and Tecra methods, respectively. Differences in results of the ELISAs compared with those of the BAM method were not statistically significant; however, differences between results of the 2 ELISA methods were significant. It was concluded that as rapid screening methods, the Listeria-Tek and the Tecra kits qualify as alternative methods to the BAM cultural method. JF - Journal - Association of Official Analytical Chemists AU - Noah, C W AU - Ramos, N C AU - Gipson, M V AD - Food and Drug Administration, Dallas, TX 75204. PY - 1991 SP - 819 EP - 821 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Reagent Kits, Diagnostic KW - 0 KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay -- instrumentation KW - Colony Count, Microbial KW - Bacteriological Techniques KW - Food Microbiology -- standards KW - Listeria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72637836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Efficiency+of+two+commercial+ELISA+kits+compared+with+the+BAM+culture+method+for+detecting+Listeria+in+naturally+contaminated+foods.&rft.au=Noah%2C+C+W%3BRamos%2C+N+C%3BGipson%2C+M+V&rft.aulast=Noah&rft.aufirst=C&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of trinomial responses from reproductive and developmental toxicity experiments. AN - 72505429; 1742429 AB - This paper presents a Dirichlet-trinomial distribution for modelling data obtained from reproductive and developmental studies. The common endpoints for the evaluation of reproductive and developmental toxic effects are the number of dead fetuses, the number of malformed fetuses, and the number of normal fetuses for each litter. With current statistical methods for the evaluation of reproductive and developmental effects, the effect on the number of deaths and the effect on the number of malformations are analyzed separately. The Dirichlet-trinomial model provides a procedure for the analysis of multiple endpoints simultaneously. This proposed Dirichlet-trinomial model is a generalization of the beta-binomial model that has been used for handling the litter effect in reproductive and developmental experiments. Likelihood ratio tests for differences in the number of deaths, the number of malformations, and the number of normals among dosed and control groups are derived. The proposed test procedure based on the Dirichlet-trinomial model is compared with that based on the beta-binomial model with an application to a real data set. JF - Biometrics AU - Chen, J J AU - Kodell, R L AU - Howe, R B AU - Gaylor, D W AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 1049 EP - 1058 VL - 47 IS - 3 SN - 0006-341X, 0006-341X KW - Teratogens KW - 0 KW - Index Medicus KW - Animals KW - Fetus -- drug effects KW - Abnormalities, Drug-Induced KW - Fetal Resorption KW - Models, Statistical KW - Female KW - Pregnancy KW - Mathematics KW - Reproduction -- drug effects KW - Teratogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Analysis+of+trinomial+responses+from+reproductive+and+developmental+toxicity+experiments.&rft.au=Chen%2C+J+J%3BKodell%2C+R+L%3BHowe%2C+R+B%3BGaylor%2C+D+W&rft.aulast=Chen&rft.aufirst=J&rft.date=1991-09-01&rft.volume=47&rft.issue=3&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts. AN - 72461848; 1944329 AB - The mutations and DNA adducts produced by the environmental pollutant 2-nitropyrene were examined in Salmonella typhimurium tester strains. 2-Nitropyrene was a stronger mutagen than its extensively studied structural isomer 1-nitropyrene in strains TA96, TA97, TA98, TA100, TA102, TA104 and TA1538. Both 1- and 2-nitropyrene were essentially inactive in TA1535. The mutagenicity of 1- and 2-nitropyrene in TA98 was much higher than in TA98NR and the activity of these compounds in TA100 was much higher than in TA100NR. While 1-nitropyrene exhibited similar mutagenicity in strains TA98 and TA98/1,8-DNP6, the mutagenicity of 2-nitropyrene in TA98/1,8-DNP6 was much lower than in TA98. Analysis of DNA from TA96 and TA104 incubated with 2-nitropyrene indicated the presence of two adducts, N-(deoxyguanosin-8-yl)-2-aminopyrene and N-(deoxyadenosin-8-yl)-2-aminopyrene. The results suggest that 2-nitropyrene is metabolized by bacterial nitroreductase(s) to N-hydroxy-2-aminopyrene, and possibly by activation to a highly mutagenic O-acetoxy ester. DNA adduct formation with deoxyguanosine and deoxyadenosine correlates with the mutagenicity of 2-nitropyrene in tester strains possessing both G:C and A:T mutational targets. JF - Mutation research AU - Yu, S Y AU - Heflich, R H AU - Von Tungeln, L S AU - el-Bayoumy, K AU - Kadlubar, F F AU - Fu, P P AD - National Center for Toxicological Research, Jefferson, AR 72079. PY - 1991 SP - 145 EP - 152 VL - 250 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Pyrenes KW - Guanine KW - 5Z93L87A1R KW - 2-nitropyrene KW - 789-07-1 KW - Adenine KW - JAC85A2161 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Adenine -- chemistry KW - Mutagenicity Tests KW - Guanine -- chemistry KW - Salmonella typhimurium -- genetics KW - Pyrenes -- toxicity KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Comparative+direct-acting+mutagenicity+of+1-+and+2-nitropyrene%3A+evidence+for+2-nitropyrene+mutagenesis+by+both+guanine+and+adenine+adducts.&rft.au=Yu%2C+S+Y%3BHeflich%2C+R+H%3BVon+Tungeln%2C+L+S%3Bel-Bayoumy%2C+K%3BKadlubar%2C+F+F%3BFu%2C+P+P&rft.aulast=Yu&rft.aufirst=S&rft.date=1991-09-01&rft.volume=250&rft.issue=1-2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-27 N1 - Date created - 1991-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - HIV infection and homeless adolescents. AN - 72445816; 1935331 AB - Homeless adolescents are at extremely high risk for acquiring HIV infection, as the literature reviewed in this paper documents. Sexual and drug use behaviors that put these adolescents at risk are described, and new models of service for these youths are outlined. JF - Child welfare AU - Athey, J L AD - Child and Adolescent Health Branch, Maternal and Child Health Bureau, U.S. Department of Health and Human Services, Rockville, MD. PY - 1991 SP - 517 EP - 528 VL - 70 IS - 5 SN - 0009-4021, 0009-4021 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Sexual Behavior KW - Adolescent Health Services -- trends KW - Humans KW - Substance Abuse, Intravenous -- complications KW - Health Services Needs and Demand -- trends KW - Adolescent KW - Substance Abuse, Intravenous -- prevention & control KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Homeless Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72445816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=HIV+infection+and+homeless+adolescents.&rft.au=Athey%2C+J+L&rft.aulast=Athey&rft.aufirst=J&rft.date=1991-09-01&rft.volume=70&rft.issue=5&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of intercellular communication in Chinese hamster V79 cells by fractionated asphalt fume condensates. AN - 72090671; 1890695 AB - Asphalt fume condensate is a skin carcinogen in mice, yet this complex mixture contains relatively low levels of known carcinogenic initiators. Consequently, its biological activity has been attributed to the presence of cocarcinogenic or tumor-promoting agents. One of several proposed mechanisms of tumor promotion is inhibition of intercellular communication. In an attempt to determine if asphalt fume has tumor-promoting potential inhibition of intercellular communication was measured in V79 cells exposed to fractionated asphalt fume condensate. Fume from air-blown Arabian crude asphalt was trapped and separated into five fractions by preparative-scale high-pressure liquid chromatography. The parent fume condensate and the five fractions inhibited intercellular communication in a concentration-dependent fashion, with a minimum effective concentration of 2.5 microgram/ml for the most potent fraction. Cytotoxicity assays were performed at the same time and concentrations as the metabolic cooperation assays. Cytotoxic responses paralleled the inhibition of intercellular communication. JF - Journal of toxicology and environmental health AU - Toraason, M AU - Bohrman, J S AU - Elmore, E AU - Wyatt, G AU - McGregor, D AU - Willington, S E AU - Zajac, W AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 95 EP - 102 VL - 34 IS - 1 SN - 0098-4108, 0098-4108 KW - Aerosols KW - 0 KW - Hydrocarbons KW - asphalt KW - 8052-42-4 KW - Index Medicus KW - Animals KW - Cell Survival -- drug effects KW - Gas Chromatography-Mass Spectrometry KW - Cell Line KW - Hydrocarbons -- chemistry KW - Cell Communication -- drug effects KW - Hydrocarbons -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72090671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Inhibition+of+intercellular+communication+in+Chinese+hamster+V79+cells+by+fractionated+asphalt+fume+condensates.&rft.au=Toraason%2C+M%3BBohrman%2C+J+S%3BElmore%2C+E%3BWyatt%2C+G%3BMcGregor%2C+D%3BWillington%2C+S+E%3BZajac%2C+W&rft.aulast=Toraason&rft.aufirst=M&rft.date=1991-09-01&rft.volume=34&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-11 N1 - Date created - 1991-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The genetic toxicology of 5-bromodeoxyuridine in mammalian cells. AN - 72061215; 1881403 AB - The thymidine analog, BrdUrd, induces many biological responses which are of importance to the field of genetic toxicology and related disciplines. These include the induction of SCE, specific-locus mutations, and toxicity, inhibition of cell proliferation, and the expression of fragile sites in the human genome. In early models which addressed the mechanisms of the biological effects of BrdUrd exposure, two pathways were proposed to account for the induction of the biological responses. Incorporation of the enol form of BrdUrd into the nascent DNA strand after pairing with deoxyguanosine was proposed as one pathway, whereas the incorporation of BrdUrd opposite adenosine in place of thymidine was proposed as the second pathway. Many novel and sophisticated techniques have been applied to the study of the mechanism of the induction of biological effects by BrdUrd leading to a substantial increase in our understanding of these mechanisms. However, the experimental evidence clearly supports the contention that BrdUrd exerts its effects on eukaryotic cells through mechanisms similar to those originally proposed to explain the genotoxicity of BrdUrd. JF - Mutation research AU - Morris, S M AD - Department of Health and Human Services, U.S. Public Health Service, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 161 EP - 188 VL - 258 IS - 2 SN - 0027-5107, 0027-5107 KW - Chromatin KW - 0 KW - DNA KW - 9007-49-2 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Animals KW - Mammals KW - Sister Chromatid Exchange KW - Chromosome Fragility KW - Chromosome Fragile Sites KW - Chromatin -- drug effects KW - Cell Division -- drug effects KW - Cell Cycle -- drug effects KW - DNA -- metabolism KW - Bromodeoxyuridine -- toxicity KW - Mutagenesis KW - DNA -- drug effects KW - Bromodeoxyuridine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72061215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+genetic+toxicology+of+5-bromodeoxyuridine+in+mammalian+cells.&rft.au=Morris%2C+S+M&rft.aulast=Morris&rft.aufirst=S&rft.date=1991-09-01&rft.volume=258&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-30 N1 - Date created - 1991-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The FDA as an information source for family physicians. AN - 72054176; 1877417 JF - American family physician AU - Rheinstein, P H AD - U.S. Food and Drug Administration, Rockville, Maryland. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 1037 EP - 1041 VL - 44 IS - 3 SN - 0002-838X, 0002-838X KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - United States KW - Periodicals as Topic KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Product Labeling -- standards KW - Diffusion of Innovation KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Drug Therapy -- standards KW - Information Services -- standards KW - Family Practice KW - United States Food and Drug Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72054176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=The+FDA+as+an+information+source+for+family+physicians.&rft.au=Rheinstein%2C+P+H&rft.aulast=Rheinstein&rft.aufirst=P&rft.date=1991-09-01&rft.volume=44&rft.issue=3&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The embryotoxicity of phenytoin: an update on possible mechanisms. AN - 72034619; 1871147 AB - PHT has multiple effects in adult humans and animals, and there is no reason to assume that it will not have multiple effects in embryos and fetuses. Although one of the first associations between anticonvulsant therapy and an adverse development effect in humans was noted in 1964 (104), the mechanism(s) whereby these adverse effects occur has thus far eluded research efforts. In this review, I have focused on three possible mechanisms. Overall, the evidence does not appear to implicate folate deficiency in PHT-induced embryotoxicity. A role for glucocorticoids or interaction between PHT and the glucocorticoid receptor has not been ruled out. However, a significant amount of work remains to be done to examine the involvement of the arachidonic acid cascade in PHT-induced embryotoxicity in vivo. The bulk of the experimental evidence would seem to favor a role for the generation of a reactive intermediate and its subsequent binding to embryonic macromolecules. This metabolite(s) has not been identified. Additionally, the association between covalent binding of metabolites and embryotoxicity remains simply an association; a causal relationship has not been established. Much work remains to be done to determine whether any of these possibilities, some other possibility, or a combination of several mechanisms will explain the adverse development effects of this very important, therapeutically useful anticonvulsant. JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) AU - Hansen, D K AD - Division of Reproductive and Developmental Toxicology, Food and Drug Administration, Department of Health and Human Services, Jefferson, Arkansas 72079. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 361 EP - 368 VL - 197 IS - 4 SN - 0037-9727, 0037-9727 KW - Glucocorticoids KW - 0 KW - Teratogens KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Glucocorticoids -- metabolism KW - Animals KW - Folic Acid Deficiency KW - Biotransformation KW - Humans KW - Phenytoin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72034619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.atitle=The+embryotoxicity+of+phenytoin%3A+an+update+on+possible+mechanisms.&rft.au=Hansen%2C+D+K&rft.aulast=Hansen&rft.aufirst=D&rft.date=1991-09-01&rft.volume=197&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.issn=00379727&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-19 N1 - Date created - 1991-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxic oil syndrome: a current clinical and epidemiologic summary, including comparisons with the eosinophilia-myalgia syndrome. AN - 72032818; 1869734 AB - In the spring and summer of 1981, an epidemic of a new illness now referred to as the toxic oil syndrome occurred in central and northwestern Spain, resulting in some 20,000 cases, 12,000 hospital admissions and greater than 300 deaths in the 1st year of the epidemic. The initial onset of illness was usually acute, and patients presented primarily with a respiratory syndrome involving cough, fever, dyspnea, hypoxemia, pulmonary infiltrates and pleural effusions. While approximately 50% of patients recovered from this acute phase of the illness without apparent sequelae, the remaining patients developed an intermediate or chronic phase, or both, of illness involving severe myalgia, eosinophilia, peripheral nerve damage, sclerodermiform skin lesions, sicca syndrome, alopecia and joint contractures, among other findings. Epidemiologic and analytic chemical studies have clearly linked the toxic oil syndrome to the ingestion of oil mixtures containing rapeseed oil denatured with aniline. However, the precise identity of the etiologic agent within this oil has never been determined. Aniline itself did not cause the illness, but the causal agent may be a reaction product of aniline with some oil component. Although many aspects of disease activity in the involved patients have lessened with time, the ultimate consequences of their disease are not clear and are the subject of ongoing study. The recently described eosinophilia-myalgia syndrome in the United States clinically resembles the toxic oil syndrome. JF - Journal of the American College of Cardiology AU - Kilbourne, E M AU - Posada de la Paz, M AU - Abaitua Borda, I AU - Diez Ruiz-Navarro, M AU - Philen, R M AU - Falk, H AD - Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, Georgia. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 711 EP - 717 VL - 18 IS - 3 SN - 0735-1097, 0735-1097 KW - Aniline Compounds KW - 0 KW - Fatty Acids, Monounsaturated KW - Plant Oils KW - canola oil KW - 331KBJ17RK KW - Tryptophan KW - 8DUH1N11BX KW - aniline KW - SIR7XX2F1K KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Poisoning -- epidemiology KW - Cardiovascular Diseases -- chemically induced KW - Spain -- epidemiology KW - United States -- epidemiology KW - Male KW - Female KW - Tryptophan -- adverse effects KW - Muscular Diseases -- chemically induced KW - Eosinophilia -- chemically induced KW - Muscular Diseases -- epidemiology KW - Eosinophilia -- epidemiology KW - Disease Outbreaks KW - Plant Oils -- poisoning KW - Brassica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72032818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Toxic+oil+syndrome%3A+a+current+clinical+and+epidemiologic+summary%2C+including+comparisons+with+the+eosinophilia-myalgia+syndrome.&rft.au=Kilbourne%2C+E+M%3BPosada+de+la+Paz%2C+M%3BAbaitua+Borda%2C+I%3BDiez+Ruiz-Navarro%2C+M%3BPhilen%2C+R+M%3BFalk%2C+H&rft.aulast=Kilbourne&rft.aufirst=E&rft.date=1991-09-01&rft.volume=18&rft.issue=3&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-19 N1 - Date created - 1991-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Alcohol practices, policies, and potentials of American colleges and universities: an OSAP white paper AN - 59571088; 1992-0111248 AB - Extent of drinking on college campuses, costs, areas of intervention open to schools, and remedies; US. JF - 5600 Fishers Lane, Rockwall II, Rockville, MD 20857, September 1991. iv+75 pp. AU - Eigen, Lewis D Y1 - 1991/09// PY - 1991 DA - September 1991 EP - iv+75 PB - 5600 Fishers Lane, Rockwall II, Rockville, MD 20857 KW - Colleges and universities -- Administration KW - United States -- Educational sector KW - Alcoholism -- United States KW - College students -- Liquor problem KW - Drinking behavior -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59571088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Eigen%2C+Lewis+D&rft.aulast=Eigen&rft.aufirst=Lewis&rft.date=1991-09-01&rft.volume=&rft.issue=&rft.spage=iv%2B75&rft.isbn=&rft.btitle=Alcohol+practices%2C+policies%2C+and+potentials+of+American+colleges+and+universities%3A+an+OSAP+white+paper&rft.title=Alcohol+practices%2C+policies%2C+and+potentials+of+American+colleges+and+universities%3A+an+OSAP+white+paper&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - 5600 Fishers Lane, Rockwall II, Rockville, MD 20857 pa N1 - Document feature - table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Interaction of forskolin with the P-glycoprotein multidrug transporter. AN - 72072279; 1679346 AB - Forskolin and 1,9-dideoxyforskolin, an analogue that does not activate adenylyl cyclase, were tested for their ability to enhance the cytotoxic effects of adriamycin in human ovarian carcinoma cells, SKOV3, which are sensitive to adriamycin and express low levels of P-glycoprotein, and a variant cell line, SKVLB, which overexpresses the P-glycoprotein and has the multidrug resistance (MDR) phenotype. Forskolin and 1,9-dideoxyforskolin both increased the cytotoxic effects of adriamycin in SKVLB cells, yet had no effect on SKOV3 cells. Two photoactive derivatives of forskolin have been synthesized, 7-O-[[2-[3-(4-azido-3- [125I]iodophenyl)propionamido]ethyl] carbamyl]-7-deacetylforskolin, 125I-7-AIPP-Fsk, and 6-O-[[2-[3-(4-azido-3- [125I]iodophenyl)propionamido]ethyl]carbamyl]forskolin, 125I-6-AIPP-Fsk, which exhibit specificity for labeling the glucose transporter and adenylyl cyclase, respectively (Morris et al., 1991). Both photolabels identified a 140-kDa protein in membranes from SKVLB cells whose labeling was inhibited by forskolin and 1,9-dideoxyforskolin. There was no specific labeling of proteins in membranes from the SKOV3 cells. The overexpressed 140-kDa protein in SKVLB membranes was identified as the P-glycoprotein by immunoblot analysis and immunoprecipitation using anti-P-glycoprotein antiserum. Total inhibition of photolabeling of the P-glycoprotein was observed with verapamil, nifedipine, diltiazem, and vinbalastine, and partial inhibition was observed with colchicine and cytochalasin B. Forskolin was less effective at inhibiting the photolabeling of the P-glycoprotein than 1,9-dideoxyforskolin or a lipophilic derivative of forskolin. The data are consistent with forskolin binding to the P-glycoprotein analogous to that of other chemosensitizing drugs that have been shown to partially reverse MDR.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Biochemistry AU - Morris, D I AU - Speicher, L A AU - Ruoho, A E AU - Tew, K D AU - Seamon, K B AD - Molecular Pharmacology Laboratory, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/08/27/ PY - 1991 DA - 1991 Aug 27 SP - 8371 EP - 8379 VL - 30 IS - 34 SN - 0006-2960, 0006-2960 KW - Affinity Labels KW - 0 KW - Carrier Proteins KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - Colforsin KW - 1F7A44V6OU KW - Doxorubicin KW - 80168379AG KW - 1,9-dideoxyforskolin KW - OAW710HWIX KW - Index Medicus KW - Drug Interactions KW - Tumor Cells, Cultured KW - Humans KW - Molecular Sequence Data KW - Drug Resistance KW - Cell Membrane -- chemistry KW - Doxorubicin -- toxicity KW - Amino Acid Sequence KW - Molecular Weight KW - Female KW - Cell Line KW - Colforsin -- pharmacology KW - Carrier Proteins -- metabolism KW - Colforsin -- analogs & derivatives KW - Neoplasm Proteins -- metabolism KW - Colforsin -- metabolism KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72072279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Interaction+of+forskolin+with+the+P-glycoprotein+multidrug+transporter.&rft.au=Morris%2C+D+I%3BSpeicher%2C+L+A%3BRuoho%2C+A+E%3BTew%2C+K+D%3BSeamon%2C+K+B&rft.aulast=Morris&rft.aufirst=D&rft.date=1991-08-27&rft.volume=30&rft.issue=34&rft.spage=8371&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-04 N1 - Date created - 1991-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Frequency of urination and its effects on metabolism, pharmacokinetics, blood hemoglobin adduct formation, and liver and urinary bladder DNA adduct levels in beagle dogs given the carcinogen 4-aminobiphenyl. AN - 80736223; 1868460 AB - The human urinary bladder carcinogen, 4-aminobiphenyl (ABP), is known to undergo hepatic metabolism to an N-hydroxy arylamine and its corresponding N-glucuronide. It has been proposed that these metabolites are both transported through the blood via renal filtration to the urinary bladder lumen where acidic pH can facilitate the hydrolysis of the N-glucuronide and enhance the conversion of N-hydroxy-4-aminobiphenyl (N-OH-ABP) to a reactive electrophile that will form covalent adducts with urothelial DNA. Blood ABP-hemoglobin adducts, which have been used to monitor human exposure to ABP, are believed to be formed by reactions within the erythrocyte involving N-OH-ABP that has entered the circulation from the liver or from reabsorption across the urothelium. To test these hypotheses directly, experimental data were obtained from female beagles given [3H]ABP (p.o., i.v., or intraurethrally). [3H]N-OH-ABP (i.v. or intraurethrally), or [3H]N-OH-ABP N-glucuronide (i.v.). Analyses included determinations of total ABP in whole blood and plasma, ABP-hemoglobin adducts in blood erythrocytes, ABP and N-OH-ABP levels (free and N-glucuronide) in urine, urine pH, frequency of urination (controlled by urethral catheter), rates of reabsorption of ABP and N-OH-ABP across the urothelium, and apparent volumes of distribution in the blood/tissue compartment. The major ABP-DNA adduct, N-(guan-8-yl)-4-aminobiphenyl, was also measured in urothelial and liver DNA using a sensitive immunochemical method. An analog/digital hybrid computer was then utilized to construct a multicompartmental pharmacokinetic model for ABP and its metabolites that separates: (a) absorption; (b) hepatic metabolism and distribution in blood and tissues; (c) ABP-hemoglobin adduct formation; (d) hydrolysis and reabsorption in the urinary bladder lumen; and (e) excretion. Using this model, cumulative exposure of the urothelium to free N-OH-ABP was simulated from the experimental data and used to predict ABP-DNA adduct formation in the urothelium. The results indicated that exposure to N-OH-ABP and subsequent ABP-DNA adduct formation are directly dependent on voiding frequency and to a lesser extent on urine pH. This was primarily due to the finding that, after p.o. dosing of ABP to dogs, the major portion of the total N-OH-ABP entering the bladder lumen was free N-OH-ABP (0.7% of the dose), with much lower amounts as the acid-labile N-glucuronide (0.3% of the dose).(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cancer research AU - Kadlubar, F F AU - Dooley, K L AU - Teitel, C H AU - Roberts, D W AU - Benson, R W AU - Butler, M A AU - Bailey, J R AU - Young, J F AU - Skipper, P W AU - Tannenbaum, S R AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/08/15/ PY - 1991 DA - 1991 Aug 15 SP - 4371 EP - 4377 VL - 51 IS - 16 SN - 0008-5472, 0008-5472 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - Hemoglobins KW - 4-biphenylamine KW - 16054949HJ KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Kinetics KW - Dogs KW - Tissue Distribution KW - Time Factors KW - Models, Biological KW - Female KW - Urinary Bladder -- metabolism KW - Aminobiphenyl Compounds -- urine KW - Aminobiphenyl Compounds -- pharmacokinetics KW - Aminobiphenyl Compounds -- blood KW - Carcinogens -- metabolism KW - Urination KW - Hemoglobins -- metabolism KW - DNA -- metabolism KW - Liver -- metabolism KW - Aminobiphenyl Compounds -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80736223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Frequency+of+urination+and+its+effects+on+metabolism%2C+pharmacokinetics%2C+blood+hemoglobin+adduct+formation%2C+and+liver+and+urinary+bladder+DNA+adduct+levels+in+beagle+dogs+given+the+carcinogen+4-aminobiphenyl.&rft.au=Kadlubar%2C+F+F%3BDooley%2C+K+L%3BTeitel%2C+C+H%3BRoberts%2C+D+W%3BBenson%2C+R+W%3BButler%2C+M+A%3BBailey%2C+J+R%3BYoung%2C+J+F%3BSkipper%2C+P+W%3BTannenbaum%2C+S+R&rft.aulast=Kadlubar&rft.aufirst=F&rft.date=1991-08-15&rft.volume=51&rft.issue=16&rft.spage=4371&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-13 N1 - Date created - 1991-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo treatment with interferon causes augmentation of IL-2 induced lymphokine-activated killer cells in the organs of mice. AN - 80719105; 1713814 AB - Interferon-alpha (IFN-alpha) has been shown to synergize with IL-2 in the regression of a variety of established murine tumours and studies are underway to explore this combination in patients with advanced cancers as well. To understand the mechanism of synergy we have studied lymphokine-activated killer (LAK) cell activity in various compartments of mice in response to IFN-alpha and IL-2 administration. The effects of IFN-gamma, TNF-alpha and IL-4 were also examined. C57BL/6 mice were injected intraperitoneally with HBSS, IL-2 alone, IFN-alpha alone or both, two times a day for 7 days. On days 4 and 8, LAK activity was tested in a 4-h chromium release in cells obtained from lungs, spleen, and liver using fresh MCA-102 tumour cells as targets. The cells from control mice failed to lyse the MCA-102 target. IL-2 caused the generation of LAK activity and an increase in total cell yield in all the organs after 3 days of injection. IFN-alpha failed to generate LAK activity but when administered along with IL-2, caused synergistic enhancement of LAK lysis of MCA-102 target cells. Cell yield in this group was lower as compared with the IL-2-treated group. LAK activity tested after 7 days of IL-2 therapy was significantly decreased compared with that observed after 3 days. However, activity remained at as high a level after 7 days of therapy as after 3 days of therapy in animals treated with IFN-alpha and IL-2. FACS analysis revealed that asialo GM-1+ (ASGM-1) and NK1.1+ cells were increased in number in IL-2 and IL-2 plus IFN-alpha-treated spleen; however, the number of these cells was similar in both groups. In the liver, ASGM-1+ cells were higher in the IL-2 plus IFN-alpha group than in the group treated with IL-2 alone. By in vitro depletion utilizing antibody and Rbc' experiments, it was clear that both ASGM-1+ and NK1.1+ cells from the spleen mediated most of the cytotoxicity of MCA-102 targets. Pre-treatment irradiation (5 Gy) of mice completely abrogated the capability of IL-2 or IL-2 plus IFN-alpha to generate LAK activity. IFN-gamma also had a stimulatory effect on IL-2 induction of LAK activity. Tumour necrosis factor-alpha (TNF-alpha) and IL-4 failed to generate LAK activity and, in combination with IL-2, no additional stimulatory effect was observed.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Clinical and experimental immunology AU - Puri, R K AU - Leland, P AD - Laboratory of Cellular Immunology, Division of Cytokine Biology, FDA, Bethesda, MD 20892. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 317 EP - 325 VL - 85 IS - 2 SN - 0009-9104, 0009-9104 KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Interleukin-4 KW - 207137-56-2 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Phenotype KW - Lymphocyte Activation KW - Animals KW - Recombinant Proteins -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Interleukin-4 -- pharmacology KW - Mice, Inbred C57BL KW - Mice KW - Drug Synergism KW - Fluorescent Antibody Technique KW - Female KW - Interleukin-2 -- pharmacology KW - Killer Cells, Lymphokine-Activated -- drug effects KW - Interferons -- pharmacology KW - Killer Cells, Lymphokine-Activated -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80719105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+immunology&rft.atitle=In+vivo+treatment+with+interferon+causes+augmentation+of+IL-2+induced+lymphokine-activated+killer+cells+in+the+organs+of+mice.&rft.au=Puri%2C+R+K%3BLeland%2C+P&rft.aulast=Puri&rft.aufirst=R&rft.date=1991-08-01&rft.volume=85&rft.issue=2&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+immunology&rft.issn=00099104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-11 N1 - Date created - 1991-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1978 Feb 15;21(2):210-20 [627428] J Exp Med. 1977 Jan 1;145(1):1-9 [187714] Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5 [4501586] Clin Exp Immunol. 1991 Jan;83(1):96-101 [1703057] J Clin Oncol. 1989 Dec;7(12):1863-74 [2685181] J Cell Physiol. 1987 Feb;130(2):276-83 [3102507] J Immunol. 1986 Jul 15;137(2):715-22 [2873187] J Immunol. 1986 Mar 1;136(5):1586-91 [2936802] J Natl Cancer Inst. 1988 May 18;80(6):425-31 [3130488] Int J Cancer. 1988 Feb 15;41(2):315-22 [3123404] Int J Cancer. 1987 Oct 15;40(4):519-24 [2444544] Cancer Res. 1988 Jan 15;48(2):260-4 [2446744] Int J Cancer. 1986 May 15;37(5):787-93 [2422129] J Immunol. 1985 Oct;135(4):2483-91 [2411797] J Immunol. 1985 Feb;134(2):977-81 [2578167] J Immunol. 1989 Dec 15;143(12):4282-6 [2512355] Cancer Res. 1988 Oct 15;48(20):5810-7 [3262413] Cancer Res. 1988 Jul 15;48(14):4011-7 [3260130] Hybridoma. 1984 Fall;3(3):301-3 [6500587] Cancer Treat Rep. 1986 May;70(5):619-24 [3518925] Int J Cancer. 1984 Sep 15;34(3):421-6 [6480158] Int J Cancer. 1987 Sep 15;40(3):365-71 [3497883] N Engl J Med. 1987 Apr 9;316(15):889-97 [3493432] J Exp Med. 1987 Sep 1;166(3):792-7 [3498002] Science. 1987 Feb 20;235(4791):895-8 [3580039] Cancer Res. 1987 Apr 15;47(8):2020-7 [3828990] J Leukoc Biol. 1985 May;37(5):597-614 [3884721] J Immunol. 1985 Aug;135(2):1488-97 [3891854] J Exp Med. 1985 May 1;161(5):1169-88 [3886826] Cancer Res. 1990 Sep 1;50(17):5543-50 [2386960] Cancer Res. 1990 Feb 15;50(4):1176-82 [2297766] J Immunol. 1984 Aug;133(2):714-8 [6203975] J Cell Sci. 1981 Jun;49:225-36 [6171576] Nature. 1981 May 28;291(5813):335-8 [6164929] J Exp Med. 1982 Jun 1;155(6):1823-41 [6176669] Int J Cancer. 1982 Dec 15;30(6):813-20 [6186614] J Immunol. 1980 Jan;124(1):199-201 [6985637] Nature. 1972 Sep 15;239(5368):167-8 [4561966] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Age-specific differences in the relationship between oral contraceptive use and breast cancer. AN - 80673609; 2067757 AB - Nearly all studies have suggested that the use of oral contraceptives (OC) is not associated with the aggregate risk of breast cancer diagnosed in women aged 20-54. Because of age-specific differences in the breast cancer-parity relationship and because of age-specific differences in other breast cancer risk factors, the Centers for Disease Control reexamined data from the Cancer and Steroid Hormone Study to assess whether OC use has different effects on the risk of breast cancer at different ages of diagnosis. This was a population-based case-control study conducted in eight geographic areas in the United States during 1980-1982. In these data, the relationship between the risk of breast cancer and OC use appeared to vary by age at diagnosis. Among women aged 20-34 years at diagnosis or interview, those who had ever used OC had a slightly increased risk of breast cancer (odds ratio 1.4, 95% confidence interval 1.0-2.1) when compared with women of the same ages who had never used OC. Among these women, there were no trends of increasing or decreasing risk with any measure of OC use. Among women aged 35-44 years, there was no association between OC use and breast cancer. Among women aged 45-54 years, those who used OC had a slightly decreased risk of breast cancer (odds ratio 0.9, 95% confidence interval 0.8-1.0). Among these women, the risk estimates decreased significantly with increasing time since first and last use. Although the slightly increased risk estimates for the youngest women are compatible with findings by other investigators, the decreased risk estimates for the oldest women have not been described in as many studies. Available data provide no reasons for changes in prescribing practices or in the use of OC as related to breast cancer risk. JF - Obstetrics and gynecology AU - Wingo, P A AU - Lee, N C AU - Ory, H W AU - Beral, V AU - Peterson, H B AU - Rhodes, P AD - Division of Reproductive Health, Centers for Disease Control, Department of Health and Human Services, Atlanta, Georgia. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 161 EP - 170 VL - 78 IS - 2 SN - 0029-7844, 0029-7844 KW - Contraceptives, Oral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Odds Ratio KW - Age Factors KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Confidence Intervals KW - Middle Aged KW - Female KW - Contraceptives, Oral -- adverse effects KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80673609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Age-specific+differences+in+the+relationship+between+oral+contraceptive+use+and+breast+cancer.&rft.au=Wingo%2C+P+A%3BLee%2C+N+C%3BOry%2C+H+W%3BBeral%2C+V%3BPeterson%2C+H+B%3BRhodes%2C+P&rft.aulast=Wingo&rft.aufirst=P&rft.date=1991-08-01&rft.volume=78&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-09 N1 - Date created - 1991-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic marijuana smoke exposure in the rhesus monkey. I. Plasma cannabinoid and blood carboxyhemoglobin concentrations and clinical chemistry parameters. AN - 72597163; 1684942 AB - This report is the first in a series about a large multidisciplinary study designed to determine whether chronic marijuana (MJ) smoke exposure results in residual behavioral and/or neuropathological alterations in the rhesus monkey. Prior to the initiation of a year of chronic MJ smoke exposure, 64 periadolescent male rhesus monkeys were trained for 1 year to perform five operant behavioral tasks and then divided, according to their performance in these tasks, into four exposure groups (n = 15-16/group): (1) a high dose (HI) group, exposed 7 days/week to the smoke of one standard MJ cigarette; (2) a low dose (LO) group, exposed on weekend days only to the smoke of a standard MJ cigarette; (3) an extracted MJ cigarette (EX) group, exposed 7 days/week to the smoke of one ethanol-extracted MJ cigarette; and (4) a sham group (SH), exposed 7 days/week to sham exposure conditions. Daily exposures for 1 year were accomplished using a mask that covered the subjects' nose and mouth. Average body weights (initially 3.7 +/- 0.5 kg, mean +/- SD) and rates of weight gain (approximately 0.1 kg/month) were the same for all groups throughout the entire experiment. During the first week of exposure, plasma concentrations of delta-9-tetrahydrocannabinol and 11-nor-9-carboxy-THC in the HI group were 59 +/- 7 (mean +/- SE) and 5.5 +/- 1.5 ng/ml, respectively, 45 min after MJ smoke administration and did not change significantly at similar times after exposure throughout the remainder of the year. Whole blood carboxyhemoglobin levels increased to approximately 13% 1 min after exposure to smoke in either the MJ or the EX groups. Comparison of blood chemistry and hematology values before, during, and after exposure indicated no differences for most parameters. During exposure, lymphocytes, alkaline phosphatase and gamma-glutamyl transferase were depressed in the HI group compared to in the SH group. During exposure, aspartate aminotransferase was elevated for both the HI and EX groups, suggesting a general effect of smoke exposure. Because these effects were transient and remained within the range of reported normal values, these data indicate that long-term, experimental exposure to MJ smoke is feasible and does not compromise the general health of the rhesus monkey. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Slikker, W AU - Paule, M G AU - Ali, S F AU - Scallet, A C AU - Bailey, J R AD - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 321 EP - 334 VL - 17 IS - 2 SN - 0272-0590, 0272-0590 KW - Cannabinoids KW - 0 KW - 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid KW - 4TPC9E4A32 KW - Dronabinol KW - 7J8897W37S KW - Carboxyhemoglobin KW - 9061-29-4 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Blood Chemical Analysis KW - Dronabinol -- blood KW - Alkaline Phosphatase -- blood KW - Nervous System Diseases -- chemically induced KW - Nervous System Diseases -- pathology KW - Leukocyte Count KW - Neutrophils -- drug effects KW - Aspartate Aminotransferases -- blood KW - Dronabinol -- analogs & derivatives KW - Body Weight -- drug effects KW - gamma-Glutamyltransferase -- blood KW - Macaca mulatta KW - Male KW - Carboxyhemoglobin -- metabolism KW - Cannabinoids -- blood KW - Marijuana Smoking -- metabolism KW - Marijuana Smoking -- adverse effects KW - Cannabinoids -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72597163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Chronic+marijuana+smoke+exposure+in+the+rhesus+monkey.+I.+Plasma+cannabinoid+and+blood+carboxyhemoglobin+concentrations+and+clinical+chemistry+parameters.&rft.au=Slikker%2C+W%3BPaule%2C+M+G%3BAli%2C+S+F%3BScallet%2C+A+C%3BBailey%2C+J+R&rft.aulast=Slikker&rft.aufirst=W&rft.date=1991-08-01&rft.volume=17&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-19 N1 - Date created - 1992-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Universal precautions and mortuary practitioners: influence on practices and risk of occupationally acquired infection. AN - 72456745; 1941282 AB - Embalming, the most common funeral practice in the United States, may expose the embalmer to infectious diseases and blood. We surveyed the 860 members of the National Selected Morticians in 1988 to estimate the incidence of self-reported occupational contact with blood and infectious disease, assess morticians' knowledge of acquired immunodeficiency syndrome (AIDS), determine their adherence to universal precautions, and identify predictors of practices designed to reduce risk of occupational exposure to infections. Of 539 (63%) respondents, 212 (39%) reported needle-stick injuries in the past 12 months, and 15 (3%) reported percutaneous exposures to the blood of a decedent with AIDS. Those rating the risk of occupationally acquired human immunodeficiency virus infection as very high or high (194/539 [36%]) were more likely to decline funerals of decedents with antemortem diagnosis of AIDS (59/194 [30%]) and/or to charge more for such funerals (133/194 [69%]) than those who rated the risk as low to moderate (31/345 [9%], 174/135 [51%]). JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Beck-Sagué, C M AU - Jarvis, W R AU - Fruehling, J A AU - Ott, C E AU - Higgins, M T AU - Bates, F L AD - Hospital Infections Program, Centers for Disease Control, Public Health Service, Atlanta, GA 30333. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 874 EP - 878 VL - 33 IS - 8 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - AIDS/HIV KW - Canada -- epidemiology KW - Protective Clothing KW - Embalming KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Wounds, Penetrating -- complications KW - United States -- epidemiology KW - Male KW - Prevalence KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Communicable Disease Control -- statistics & numerical data KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Mortuary Practice KW - Occupational Diseases -- prevention & control KW - Acquired Immunodeficiency Syndrome -- transmission KW - Health Knowledge, Attitudes, Practice KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72456745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Universal+precautions+and+mortuary+practitioners%3A+influence+on+practices+and+risk+of+occupationally+acquired+infection.&rft.au=Beck-Sagu%C3%A9%2C+C+M%3BJarvis%2C+W+R%3BFruehling%2C+J+A%3BOtt%2C+C+E%3BHiggins%2C+M+T%3BBates%2C+F+L&rft.aulast=Beck-Sagu%C3%A9&rft.aufirst=C&rft.date=1991-08-01&rft.volume=33&rft.issue=8&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-06 N1 - Date created - 1991-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monitoring the performance of occupational health laboratories. AN - 72163355; 1656722 AB - To monitor the performance of occupational health laboratories analyzing workplace air, the American Industrial Hygiene Association (AIHA), with assistance from the National Institute for Occupational Safety and Health, has established four national quality assurance programs. They are the Proficiency Analytical Testing (PAT) Program, the AIHA Laboratory Accreditation Program, the Asbestos Analysts Registry, and the Bulk Quality Assurance Program. This paper focuses on the PAT program, a quality audit program that provides samples of asbestos, silica, metals, and solvents to laboratories quarterly. PAT data for asbestos, silica, and lead were examined for trends in precision. Simple graphs of coefficient of variation during the 18-yr history of the program provide evidence of improved agreement among laboratories performing these analyses. The improvement took place in spite of growth in the number of laboratories and decreases in the levels being analyzed. The improvement is attributed to several factors, including improved analytical methods and the very existence of the PAT and AIHA Laboratory Accreditation Programs. JF - American Industrial Hygiene Association journal AU - Abell, M T AU - Doemeny, L J AD - Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 336 EP - 339 VL - 52 IS - 8 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Asbestos KW - 1332-21-4 KW - Lead KW - 2P299V784P KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Asbestos -- analysis KW - Silicon Dioxide -- analysis KW - Air Pollutants, Occupational -- analysis KW - Humans KW - Environmental Monitoring -- standards KW - Quality Control KW - Lead -- analysis KW - Occupational Health KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72163355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Monitoring+the+performance+of+occupational+health+laboratories.&rft.au=Abell%2C+M+T%3BDoemeny%2C+L+J&rft.aulast=Abell&rft.aufirst=M&rft.date=1991-08-01&rft.volume=52&rft.issue=8&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-01 N1 - Date created - 1991-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Too much of a good thing? Questions about fluorosis explored. AN - 72140832; 1918691 JF - Journal of the American Dental Association (1939) AU - Mason, J O AD - News Division, Public Health Service, Washington, D.C. 20201. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 93 EP - 96 VL - 122 IS - 8 SN - 0002-8177, 0002-8177 KW - Carcinogens KW - 0 KW - Mouthwashes KW - Toothpastes KW - Fluorides KW - Q80VPU408O KW - Dentistry KW - Index Medicus KW - Bone Neoplasms -- chemically induced KW - Humans KW - Mouthwashes -- adverse effects KW - Toothpastes -- adverse effects KW - Fluorosis, Dental -- etiology KW - Fluorosis, Dental -- epidemiology KW - Fluoridation -- adverse effects KW - Fluorides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72140832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Too+much+of+a+good+thing%3F+Questions+about+fluorosis+explored.&rft.au=Mason%2C+J+O&rft.aulast=Mason&rft.aufirst=J&rft.date=1991-08-01&rft.volume=122&rft.issue=8&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-13 N1 - Date created - 1991-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bacterial mutagenicity testing of 49 food ingredients gives very few positive results. AN - 72035995; 1870621 AB - 49 substances permitted for use in food in the United States was tested for mutagenicity in the Ames Salmonella typhimurium assay and in Escherichia coli strain WP2. Four of these substances caused increases in revertant counts in S. typhimurium. Two of these four (papain and pepsin) were found to contain histidine, and therefore the results of the tests on these two substances could not be taken as demonstrating mutagenicity. The other two substances causing increases in revertant counts (hydrogen peroxide and potassium nitrite) were mutagenic. The results on one chemical, beta-carotene, were evaluated as inconclusive or questionable. The remaining 44 substances were nonmutagenic in the test systems used. It is concluded that, for those generally physiologically innocuous chemicals tested, there are very few 'false positives' in the bacterial test systems used. JF - Mutation research AU - Prival, M J AU - Simmon, V F AU - Mortelmans, K E AD - Toxicology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 321 EP - 329 VL - 260 IS - 4 SN - 0027-5107, 0027-5107 KW - Food Additives KW - 0 KW - Mutagens KW - beta Carotene KW - 01YAE03M7J KW - Carotenoids KW - 36-88-4 KW - Histidine KW - 4QD397987E KW - Index Medicus KW - Histidine -- chemistry KW - Carotenoids -- toxicity KW - Mutagenicity Tests KW - Escherichia coli -- drug effects KW - Salmonella typhimurium -- drug effects KW - Food Additives -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72035995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Bacterial+mutagenicity+testing+of+49+food+ingredients+gives+very+few+positive+results.&rft.au=Prival%2C+M+J%3BSimmon%2C+V+F%3BMortelmans%2C+K+E&rft.aulast=Prival&rft.aufirst=M&rft.date=1991-08-01&rft.volume=260&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-17 N1 - Date created - 1991-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Family-centered comprehensive care for children with HIV infection: a guide AN - 59589155; 1992-0203837 AB - Scope of the problem, elements of care, and organizing, coordinating, and financing a system of community based care programs. JF - 5600 Fishers Lane, Rockville, MD 20857, August 1991. 91 pp. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 91 PB - 5600 Fishers Lane, Rockville, MD 20857 KW - Children -- Medical care KW - Child health -- United States KW - United States -- Health policy KW - Social service -- Work with families KW - Community health services -- United States KW - Acquired immune deficiency syndrome -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59589155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Family-centered+comprehensive+care+for+children+with+HIV+infection%3A+a+guide&rft.title=Family-centered+comprehensive+care+for+children+with+HIV+infection%3A+a+guide&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - 5600 Fishers Lane, Rockville, MD 20857 pa N1 - Document feature - il(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Effects of weathering on metal releases from an engineered deposit for alum shale leaching residues AN - 50486759; 1992-007229 JF - Water, Air and Soil Pollution AU - Allard, B AU - Arsenie, I AU - Hakansson, K AU - Karlsson, S AU - Ahlberg, A C AU - Lundgren, T AU - Collin, M AU - Rasmuson, A AU - Strandell, E A2 - Adriano, Domy C. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 431 EP - 440 PB - Reidel, Dordrecht VL - 57-58 SN - 0049-6979, 0049-6979 KW - copper KW - Europe KW - alum KW - Ranstad KW - iron KW - Billingen Mountain KW - sedimentary rocks KW - environmental geology KW - geochemistry KW - Western Europe KW - sulfates KW - shale KW - pollution KW - weathering KW - Scandinavia KW - metals KW - nickel KW - uranium KW - waste disposal KW - leaching KW - clastic rocks KW - actinides KW - Sweden KW - field studies KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50486759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air+and+Soil+Pollution&rft.atitle=Effects+of+weathering+on+metal+releases+from+an+engineered+deposit+for+alum+shale+leaching+residues&rft.au=Allard%2C+B%3BArsenie%2C+I%3BHakansson%2C+K%3BKarlsson%2C+S%3BAhlberg%2C+A+C%3BLundgren%2C+T%3BCollin%2C+M%3BRasmuson%2C+A%3BStrandell%2C+E&rft.aulast=Allard&rft.aufirst=B&rft.date=1991-08-01&rft.volume=57-58&rft.issue=&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air+and+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ L2 - http://www.springerlink.com/(hi4cjunvnzs4hnradzi0ib55)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100344,1 LA - English DB - GeoRef N1 - Conference title - Metals in soils, waters, plants and animals N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - WAPLAC N1 - SubjectsTermNotLitGenreText - actinides; alum; Billingen Mountain; clastic rocks; copper; environmental geology; Europe; field studies; geochemistry; iron; leaching; metals; nickel; pollution; Ranstad; Scandinavia; sedimentary rocks; shale; sulfates; Sweden; uranium; waste disposal; weathering; Western Europe ER - TY - JOUR T1 - Response of alveolar macrophages to in vitro exposure to freshly fractured versus aged silica dust: the ability of Prosil 28, an organosilane material, to coat silica and reduce its biological reactivity. AN - 80703257; 1649918 AB - We have reported previously that crushing or grinding crystalline silica results in the generation of silica-based radicals on the particulate surface and that these radicals can generate hydroxyl radicals in aqueous solution. Data in the present study indicate that freshly ground silica is more cytotoxic and is a more potent activator of alveolar macrophages than comparably sized aged silica. That is, compared to aged silica, fresh silica is 4.2-fold more potent in decreasing the membrane integrity of macrophages; is 50% more potent in activating hydrogen peroxide secretion by macrophages; and is 4.6-fold more potent in stimulating cellular chemiluminescence. Prosil 28, an organosilane material, is an effective coating agent for fresh silica. It decreases the cytotoxicity of fresh silica by as much as 78% and decreases the ability of fresh silica to induce chemiluminescence from alveolar macrophages by 58%. The data suggest that surface radicals associated with freshly cleaved dust may be an important factor in the induction of pulmonary disease. Furthermore, treating dust with coating agents may substantially decrease toxicity. JF - Journal of toxicology and environmental health AU - Vallyathan, V AU - Kang, J H AU - Van Dyke, K AU - Dalal, N S AU - Castranova, V AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 303 EP - 315 VL - 33 IS - 3 SN - 0098-4108, 0098-4108 KW - Silanes KW - 0 KW - Silicon Dioxide KW - 7631-86-9 KW - Prosil 28 KW - 81138-65-0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Hydrogen Peroxide -- metabolism KW - Male KW - Pulmonary Alveoli -- metabolism KW - Silanes -- pharmacology KW - Pulmonary Alveoli -- drug effects KW - Silicon Dioxide -- toxicity KW - Macrophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80703257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Response+of+alveolar+macrophages+to+in+vitro+exposure+to+freshly+fractured+versus+aged+silica+dust%3A+the+ability+of+Prosil+28%2C+an+organosilane+material%2C+to+coat+silica+and+reduce+its+biological+reactivity.&rft.au=Vallyathan%2C+V%3BKang%2C+J+H%3BVan+Dyke%2C+K%3BDalal%2C+N+S%3BCastranova%2C+V&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=1991-07-01&rft.volume=33&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment. AN - 80701374; 1856880 AB - Several F1 mouse hybrids were used in a chronic bioassay to determine whether such an experimental design would provide greater statistical power than using only the B6C3F1 hybrid. For this purpose, the dose response of formation of hepatocellular and bladder tumors after 30 mo of feeding 2-acetylaminofluorene (2-AAF) in the diet was assessed in 4 F1 mouse hybrids, including the B6C3F1 hybrid. No strain background-related differences in frequency of bladder neoplasms between any F1 hybrids were detected. Bladder tumors occurred only at the highest 2-AAF dose in female mice. In males the lowest dose was already sufficient to induce bladder neoplasms with incidences of 25-48% adjusted for different nontumor mortality patterns across doses. No marked strain-related differences in hepatocellular tumor rates were apparent in either sex. Higher frequencies of hepatocellular neoplasms were observed among the untreated control males of the B6C3, AY, and CVA F1 hybrids than among the comparable females. Among treated mice, the lowest 2-AAF dose increased liver tumor incidence, more so among the females than among the males. The different background genomes resulted in somewhat different risk assessments for liver tumor formation in males due to differences in the time-to-tumor curves. Except for the much higher background liver tumor rate in the CVY mice, the adjusted liver tumor incidences were similar across the four hybrids. Hence, the levels of statistical significance obtained for dose-response trends and comparisons of treated and control groups were similar using 48 animals per dose groups with B6C3 mice, or combinations of 24 animals per dose from 2 genotypes, or 12 animals per dose from the 4 hybrid genotypes. Estimates of carcinogenic potency for bladder tumors were similar, within a factor of two, across the four hybrids. However, estimates of liver tumor potency across genotypes varied by a factor of two and six for females and males, respectively. Thus, the mean of cancer potency estimates across these genotypes would be more representative for mice than results from any single genotype. As in chronic carcinogenesis studies with other test agents, neoplasms developed in only a certain proportion, rather than in all, of the genetically identical animals exposed to a given dose of the toxicant for the same length of time under the same controlled environmental conditions. This phenotypic variability in toxic responses may reflect differential regulation of gene expression among the genetically identical test animals. JF - Journal of toxicology and environmental health AU - Wolff, G L AU - Gaylor, D W AU - Blackwell, B N AU - Moore, G E AD - National Center for Toxicological Research, Food and Drug Administration, U.S. Department of Health and Human Services, Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 327 EP - 348 VL - 33 IS - 3 SN - 0098-4108, 0098-4108 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Genotype KW - Animals KW - Sex Factors KW - Risk Factors KW - Mice KW - Species Specificity KW - Male KW - Female KW - Liver Neoplasms, Experimental -- genetics KW - 2-Acetylaminofluorene -- toxicity KW - Urinary Bladder Neoplasms -- genetics KW - Liver Neoplasms, Experimental -- chemically induced KW - Papilloma -- genetics KW - Papilloma -- chemically induced KW - Urinary Bladder Neoplasms -- chemically induced KW - Carcinoma -- genetics KW - Carcinoma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80701374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Bladder+and+liver+tumorigenesis+induced+by+2-acetylaminofluorene+in+different+F1+mouse+hybrids%3A+variation+within+genotypes+and+effects+of+using+more+than+one+genotype+on+risk+assessment.&rft.au=Wolff%2C+G+L%3BGaylor%2C+D+W%3BBlackwell%2C+B+N%3BMoore%2C+G+E&rft.aulast=Wolff&rft.aufirst=G&rft.date=1991-07-01&rft.volume=33&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenesis and DNA adduct formation by 1-nitropyrene in Chinese hamster ovary cells without exogenous metabolic activation. AN - 80690888; 1853350 AB - The direct-acting mutagenicity of 1-nitropyrene (1-NP), a tumorigenic environmental pollutant and model nitropolycyclic aromatic hydrocarbon, was studied in Chinese hamster ovary (CHO) cells. Previous reports indicated that 1-NP, a potent direct-acting mutagen in Salmonella typhimurium, was mutagenic in CHO cells only in the presence of an exogenous activation system. In this study, a DNA-repair-deficient CHO cell line, CHO-UV5, and the repair-proficient CHO-K1-BH4 cell line were used to measure the direct-acting mutagenicity of highly purified samples of 1-NP. Exposure of CHO-K1-BH4 cells for 5, 12, and 24 hr did not increase mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus (p greater than 0.1; paired t test; n = 5-6), while treatment of CHO-UV5 cells for 24 hr produced a statistically significant induction of mutants (22 +/- 6 mutants per 10(6) clonable cells vs a solvent control value of 9 +/- 3 per 10(6) cells; p less than 0.01; n = 6). 32P-Postlabeling analysis of the DNA adducts formed in CHO-UV5 cells following 1-NP exposure revealed the presence of a single major adduct. Based on its chromatographic properties, its sensitivity to nuclease P1 digestion, and its resistance to hydrazine treatment, the adduct appeared to be N-(deoxyguanosin-8-yl)-1-aminopyrene, which was presumably produced by nitroreduction of 1-NP to N-hydroxy-1-aminopyrene. These results suggest that the use of extended treatment times and DNA-repair-deficient cells may be required to assess adequately the mutagenicity of nitropolycyclic aromatic hydrocarbons in CHO cells. JF - Toxicology and applied pharmacology AU - Thornton-Manning, J R AU - Smith, B A AU - Beland, F A AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 538 EP - 546 VL - 109 IS - 3 SN - 0041-008X, 0041-008X KW - Pyrenes KW - 0 KW - DNA KW - 9007-49-2 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Ovary -- metabolism KW - Animals KW - Cricetulus KW - Cells, Cultured KW - Ovary -- drug effects KW - Autoradiography KW - Female KW - Cricetinae KW - Pyrenes -- toxicity KW - Mutagenesis -- drug effects KW - DNA Repair -- drug effects KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80690888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Mutagenesis+and+DNA+adduct+formation+by+1-nitropyrene+in+Chinese+hamster+ovary+cells+without+exogenous+metabolic+activation.&rft.au=Thornton-Manning%2C+J+R%3BSmith%2C+B+A%3BBeland%2C+F+A%3BHeflich%2C+R+H&rft.aulast=Thornton-Manning&rft.aufirst=J&rft.date=1991-07-01&rft.volume=109&rft.issue=3&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-21 N1 - Date created - 1991-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Target tissue specificity of retinoic acid-induced stress proteins and malformations in mice. AN - 72494326; 1957259 AB - Retinoic acid (RA) is teratogenic in rodents and also induces the synthesis of stress proteins in fetal mouse limb buds. To determine if the RA induction of stress proteins is target tissue specific, pregnant CD-1 mice were gavaged with 100 mg/kg RA on day 11 of gestation, and nuclei isolated from tissues susceptible to RA-induced malformations (target tissues) as well as nuclei isolated from nontarget tissues were examined for stress protein synthesis and malformations. Forelimb and hindlimb (target tissues), as well as heart and tail (nontarget tissues), were removed from embryos 2.5 hours after RA treatment (1.5 hr after [3H]leucine labeling). Cell nuclei were isolated, stained with a DNA specific fluorochrome, propidium iodide, and sorted from the G0 + G1 and G2 + M phases of the cell cycle. Forelimb and hindlimb target tissues showed the synthesis in these embryonic nuclear proteins of an 84,000 relative molecular mass (Mr) protein and a 90,000 Mr protein following RA treatment. Two 20,000-25,000 Mr stress proteins were also labeled both in forelimb and hindlimb. Forelimb and hindlimb from untreated dams showed no stress protein labeling. Neither heart nor tail, nontarget tissues, showed any stress protein labeling following RA treatment. Classical teratological evaluation of embryos treated on GD 11 and sacrificed on GD 17 showed that 100% of the fetuses had forelimb and/or hindlimb malformations, while no malformations were observed in either the heart or tail. Based on the correlation of teratological anomalies with the identification of stress proteins in target tissue only, we postulate that stress proteins may be involved in the teratogenic process. Further work is necessary to establish whether a causal relationship exists. JF - Teratology AU - Anson, J F AU - Laborde, J B AU - Pipkin, J L AU - Hinson, W G AU - Hansen, D K AU - Sheehan, D M AU - Young, J F AD - Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 19 EP - 28 VL - 44 IS - 1 SN - 0040-3709, 0040-3709 KW - Heat-Shock Proteins KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Mice KW - Bone and Bones -- abnormalities KW - Tretinoin -- toxicity KW - Heat-Shock Proteins -- biosynthesis KW - Abnormalities, Drug-Induced -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72494326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Target+tissue+specificity+of+retinoic+acid-induced+stress+proteins+and+malformations+in+mice.&rft.au=Anson%2C+J+F%3BLaborde%2C+J+B%3BPipkin%2C+J+L%3BHinson%2C+W+G%3BHansen%2C+D+K%3BSheehan%2C+D+M%3BYoung%2C+J+F&rft.aulast=Anson&rft.aufirst=J&rft.date=1991-07-01&rft.volume=44&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-30 N1 - Date created - 1991-12-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Teratology. 1992 Feb;45(2):121-4 [1615421] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638. AN - 72482171; 1950818 AB - In this study, we investigated the effect of ST638, a novel tyrosine kinase inhibitor, on TPA and ionomycin-stimulated PGE2 production after transfection of c-fms encoded CSF-1 receptor (CSF-1R) DNA (with or without transforming activity) into the myeloid progenitor cell line, 32D. ST638 inhibited prostaglandin E2 (PGE2) production induced after transfection of normal c-fms into 32D cell line, but failed to inhibit PGE2 production induced in 32D cells transformed with c-fms containing a point mutation at tyrosine 969 in the intracellular domain (substitution with phenylalanine) and at leucine 301 in the extracellular domain (substitution with serine). The selective effect on PGE2 production in normal c-fms-bearing cells by ST638 may indicate the presence of different induction pathways, one sensitive to ST638 and the other not. Alternatively, the phosphorylation site at tyr969 in c-fms may be a site of ST638 action, and upon its removal from the transforming c-fms, ST638 loses its inhibitory effect. JF - Agents and actions AU - Puri, J AU - Pierce, J H AU - Hoffman, T AD - Laboratory of Cell Biology, U.S. Food and Drug Administration, Bethesda, MD. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 314 EP - 317 VL - 33 IS - 3-4 SN - 0065-4299, 0065-4299 KW - Cinnamates KW - 0 KW - Indicators and Reagents KW - Interleukin-3 KW - Receptors, Colony-Stimulating Factor KW - Sulfides KW - ST 638 KW - 107761-24-0 KW - Arachidonic Acid KW - 27YG812J1I KW - Ionomycin KW - 56092-81-0 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phenotype KW - Transfection KW - Cells, Cultured KW - Humans KW - Interleukin-3 -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Ionomycin -- pharmacology KW - Arachidonic Acid -- metabolism KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Receptors, Colony-Stimulating Factor -- genetics KW - Dinoprostone -- biosynthesis KW - Cinnamates -- pharmacology KW - Sulfides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72482171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agents+and+actions&rft.atitle=Selective+inhibition+of+PGE2+production+in+cells+transfected+with+c-fms+encoded+CSF-1+receptor+genes+by+the+tyrosine+kinase+inhibitor%2C+ST638.&rft.au=Puri%2C+J%3BPierce%2C+J+H%3BHoffman%2C+T&rft.aulast=Puri&rft.aufirst=J&rft.date=1991-07-01&rft.volume=33&rft.issue=3-4&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Agents+and+actions&rft.issn=00654299&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-23 N1 - Date created - 1991-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Homosexual men who engage in high-risk sexual behavior. A multicenter comparison. AN - 72473888; 1948516 AB - To describe homosexual men who continue to engage in unprotected oral and anal sex, 601 men who attended three urban STD clinics and who had engaged in these behaviors with a male partner in the previous 4 months were interviewed regarding their sexual and drug-use behaviors. Although approximately one fourth of participants had engaged in 1 to 2 episodes of unprotected anal sex, more than 20% reported engaging in greater than 23 episodes. Higher frequency of anal sex was associated with lower condom use rates. Although 50% had primary relationships, less than 22% had sex with just one partner, and less than 10% were in relationships concordant for HIV-antibody status. Multiple regression analyses showed that number of drugs used each month, sex in a steady relationship, and Hispanic ethnicity were the most consistent predictors of risk behavior across sites. Careful evaluation of the diverse nature and characteristics of these men is essential to target risk-reduction programs for this population. JF - Sexually transmitted diseases AU - Doll, L S AU - Byers, R H AU - Bolan, G AU - Douglas, J M AU - Moss, P M AU - Weller, P D AU - Joy, D AU - Bartholow, B N AU - Harrison, J S AD - Division of HIV/AIDS, Center for Infectious Diseases, Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, Georgia 30333. PY - 1991 SP - 170 EP - 175 VL - 18 IS - 3 SN - 0148-5717, 0148-5717 KW - HIV Antibodies KW - 0 KW - Index Medicus KW - Population KW - AIDS/HIV KW - United States KW - Family Characteristics KW - Measurement KW - Laboratory Examinations And Diagnoses KW - Immunologic Factors KW - Barrier Methods KW - Research Methodology KW - Sex Behavior KW - Physiology KW - Antibodies--analysis KW - Contraceptive Methods KW - Developed Countries KW - Population At Risk KW - Population Characteristics KW - Homosexuals--men KW - Sampling Studies KW - Hispanics--men KW - Demographic Factors KW - Family Planning KW - Urban Population KW - North America KW - Americas KW - Surveys KW - Studies KW - Immunity KW - Cross Sectional Analysis KW - Alcohol Drinking KW - Couples KW - Condom KW - Northern America KW - Contraception KW - Behavior KW - Ethnic Groups KW - Risk Factors KW - Examinations And Diagnoses KW - Family And Household KW - Drug Usage KW - Cultural Background KW - Biology KW - Regression Analysis KW - Humans KW - African Americans KW - Aged KW - Chicago KW - San Francisco KW - HIV Antibodies -- blood KW - Hispanic Americans KW - Bisexuality KW - Adult KW - Middle Aged KW - Colorado KW - Male KW - Substance-Related Disorders -- epidemiology KW - Contraceptive Devices, Male KW - Sexual Behavior KW - Health Behavior KW - Homosexuality KW - Sexually Transmitted Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72473888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+diseases&rft.atitle=Homosexual+men+who+engage+in+high-risk+sexual+behavior.+A+multicenter+comparison.&rft.au=Doll%2C+L+S%3BByers%2C+R+H%3BBolan%2C+G%3BDouglas%2C+J+M%3BMoss%2C+P+M%3BWeller%2C+P+D%3BJoy%2C+D%3BBartholow%2C+B+N%3BHarrison%2C+J+S&rft.aulast=Doll&rft.aufirst=L&rft.date=1991-07-01&rft.volume=18&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+diseases&rft.issn=01485717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-02 N1 - Date created - 1991-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heat and cold in farm workers. AN - 72470342; 1948525 JF - Occupational medicine (Philadelphia, Pa.) AU - Brown, W D AD - Federal Employee Occupational Health, U.S. Public Health Service, Seattle, WA 98121-2500. PY - 1991 SP - 371 EP - 389 VL - 6 IS - 3 SN - 0885-114X, 0885-114X KW - Index Medicus KW - United States KW - Heart Rate KW - Primary Prevention KW - Body Temperature KW - Maximum Allowable Concentration KW - Humans KW - Body Temperature Regulation -- physiology KW - Acclimatization -- physiology KW - United States Occupational Safety and Health Administration KW - Monitoring, Physiologic KW - Hypothermia -- prevention & control KW - Agricultural Workers' Diseases -- metabolism KW - Hypothermia -- metabolism KW - Agricultural Workers' Diseases -- prevention & control KW - Heat Exhaustion -- metabolism KW - Agricultural Workers' Diseases -- etiology KW - Heat Exhaustion -- prevention & control KW - Hypothermia -- etiology KW - Heat Exhaustion -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72470342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Heat+and+cold+in+farm+workers.&rft.au=Brown%2C+W+D&rft.aulast=Brown&rft.aufirst=W&rft.date=1991-07-01&rft.volume=6&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-04 N1 - Date created - 1991-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of magnesium on the growth and cell cycle of transformed and non-transformed epithelial rat liver cells in vitro. AN - 72445468; 1933512 AB - The effects of magnesium (Mg) restriction on cell growth and the cell cycle were determined in transformed (TRL-8) and non-transformed (TRL-12-15) epithelial-like rat liver cells. Cells were cultured in RPMI 1640 medium in which the Mg concentration was reduced to 0.5, 0.1, and 0 x the concentration in the regular RPMI 1640 media (100mg/l). Cell growth in the transformed cells was not influenced by the Mg restriction as greatly as in the non-transformed cell line. Transit through the cell cycle also exhibited an independence of the Mg in the medium in the transformed cells. When transformed cells were grown for two generations in Mg-limited medium, the growth rate slowed to a rate similar to that demonstrated by the non-transformed cells. Analysis by flow cytometry showed that transit through the cell cycle was minimally slowed in Mg deficient transformed cells; however, transit through the G1 and S phases in the non-transformed cells was slowed. The TRL-8 cells in Mg-limited medium resulted in fewer nuclei in G1 with subsequent increases in the percentages of S-phase nuclei. The TRL 12-15 cells reacted oppositely with the number of G1 nuclei increased and the number of S-phase nuclei decreased. In respect to growth, these results show that epithelial cells respond in a similar manner to Mg-limitation as do fibroblast cells. The transformed cells exhibited a level of independence from Mg in respect to growth, reproduction, and cell-cycle kinetics. JF - Cell biology and toxicology AU - Littlefield, N A AU - Hass, B S AU - McGarrity, L J AU - Morris, S M AD - U.S. Public Health Service, Food and Drug Administration National Center for Toxicological Research Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 203 EP - 214 VL - 7 IS - 3 SN - 0742-2091, 0742-2091 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Rats KW - Animals KW - Epithelial Cells KW - Flow Cytometry KW - Cell Line, Transformed KW - Epithelium -- drug effects KW - Cell Line KW - Liver -- cytology KW - Liver -- drug effects KW - Magnesium -- toxicity KW - Cell Division -- drug effects KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72445468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Effect+of+magnesium+on+the+growth+and+cell+cycle+of+transformed+and+non-transformed+epithelial+rat+liver+cells+in+vitro.&rft.au=Littlefield%2C+N+A%3BHass%2C+B+S%3BMcGarrity%2C+L+J%3BMorris%2C+S+M&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1991-07-01&rft.volume=7&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-09 N1 - Date created - 1991-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative study of intracellular glutathione content in rat lymphocyte cultures treated with 2-mercaptoethanol and interleukin-2. AN - 72445429; 1933513 AB - The level of intracellular glutathione (GSH) in mitogen-stimulated mouse lymphocytes is increased in the presence of 2-mercaptoethanol (2-ME), an enhancer of lymphocyte activation and proliferation. Since proliferation of lymphocytes in response to mitogens involves direct activation by a mitogen followed by continued proliferation in response to interleukin-2 (IL-2), we have investigated the effect of 2-ME and exogenous IL-2 on the GSH content and cell proliferation of rat lymphocytes stimulated with phytohemagglutinin (PHA). PHA stimulation increased both GSH content and the magnitude of the proliferative response, as measured by thymidine incorporation into cellular DNA. However, incubation of stimulated lymphocytes with 2-ME or IL-2 for 72 hr produced a significant further elevation of GSH levels and thymidine incorporation. 2-ME also increased the GSH content in unstimulated cultures, but it had little effect on thymidine incorporation. IL-2 increased GSH content and decreased thymidine incorporation in unstimulated lymphocytes. Exposure of cells to DL-buthionine-(S,R)-sulfoximine (BSO), an inhibitor of GSH biosynthesis, significantly depleted GSH and lowered the proliferative response, suggesting a crucial role of de novo GSH synthesis for lymphocyte activation. The data suggest that both 2-ME and IL-2 promote lymphocyte proliferation, although the mechanisms by which intracellular GSH levels are increased by the agents are apparently different. JF - Cell biology and toxicology AU - Aidoo, A AU - Lyn-Cook, L E AU - Morris, S M AU - Kodell, R L AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration National Center for Toxicological Research Jefferson, Arkansas 72079-9502. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 215 EP - 227 VL - 7 IS - 3 SN - 0742-2091, 0742-2091 KW - Interleukin-2 KW - 0 KW - Methionine Sulfoximine KW - 1982-67-8 KW - Buthionine Sulfoximine KW - 5072-26-4 KW - Mercaptoethanol KW - 60-24-2 KW - DNA KW - 9007-49-2 KW - Glutathione KW - GAN16C9B8O KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Methionine Sulfoximine -- toxicity KW - Methionine Sulfoximine -- analogs & derivatives KW - DNA -- biosynthesis KW - Male KW - Lymphocytes -- chemistry KW - Mercaptoethanol -- toxicity KW - Glutathione -- analysis KW - Interleukin-2 -- toxicity KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72445429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Comparative+study+of+intracellular+glutathione+content+in+rat+lymphocyte+cultures+treated+with+2-mercaptoethanol+and+interleukin-2.&rft.au=Aidoo%2C+A%3BLyn-Cook%2C+L+E%3BMorris%2C+S+M%3BKodell%2C+R+L%3BCasciano%2C+D+A&rft.aulast=Aidoo&rft.aufirst=A&rft.date=1991-07-01&rft.volume=7&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-09 N1 - Date created - 1991-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of cyanide poisoning. AN - 72148689; 1922842 AB - The object of this study was to evaluate the effectiveness of five regimens in treating cyanide poisoning. A series of anesthetized adult beagle dogs were instrumented to record hemodynamic and respiratory function and given 2.5 mg/kg sodium cyanide intravenously. The 10 control animals given only cyanide died at from 5 to 7 minutes. Therapy, as described below, was given to other groups at from 2 to 3 minutes following the cyanide administration. Artificial respiration did not alter the lethal effects of cyanide nor prolong survival time in any of the 10 animals. Amyl nitrite given by inhalation or by the intravenous route allowed survival of all 15 animals. Sodium nitrite (20 mg/kg), dimethylaminophenol (DMAP) (5 mg/kg), and hydroxylamine hydrochloride (5 mg/kg) given intravenously with no artificial ventilation also allowed for 100% survival (15 animals). Amyl nitrite, sodium nitrite, and sodium thiosulfate were ineffective when given intramuscularly (I.M.) (0 of 12 dogs); however, I.M. DMAP (5 mg/kg) and I.M. hydroxylamine hydrochloride (50 mg/kg) increased heart rate and blood pressure and restored spontaneous breathing. All 15 animals treated with I.M. doses of either of these drugs survived the lethal dose of cyanide. Results of these studies indicate that intravenous sodium nitrite, DMAP, and hydroxylamine hydrochloride, and amyl nitrite by inhalation, are all effective in reversing the lethal effects of cyanide poisoning. Only DMAP and hydroxylamine hydrochloride are effective when given by the intramuscular route. These results provide data to support an approach to therapy that is more practical and applicable where expert medical care may not be available following cyanide exposure. JF - Military medicine AU - Vick, J A AU - Froehlich, H AD - Food and Drug Administration, Washington, DC 20204. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 330 EP - 339 VL - 156 IS - 7 SN - 0026-4075, 0026-4075 KW - Cyanides KW - 0 KW - Index Medicus KW - Animals KW - Poisoning -- physiopathology KW - Dogs KW - Poisoning -- drug therapy KW - Cyanides -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72148689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Treatment+of+cyanide+poisoning.&rft.au=Vick%2C+J+A%3BFroehlich%2C+H&rft.aulast=Vick&rft.aufirst=J&rft.date=1991-07-01&rft.volume=156&rft.issue=7&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-20 N1 - Date created - 1991-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhanced supercritical fluid carbon dioxide extraction of pesticides from foods using pelletized diatomaceous earth. AN - 72138316; 1917813 AB - Supercritical fluid carbon dioxide (SC-CO2), when used with an extraction enhancer, comprises a supercritical fluid extraction (SFE) system for extraction of pesticides and matrix components from fatty and nonfatty foods. After being mixed with the enhancer, samples ranging from 95% water to pure lipophilic oils can be extracted efficiently with SC-CO2. This extraction technique yields analyte recoveries in excess of 85% for over 30 types of pesticides at incurred levels ranging from 0.005 to 2 ppm in such diverse matrixes as carrots, lettuce, peanut butter, hamburger, and fortified butter fat and fortified potatoes. SC-CO2 provides a solvent medium that is nontoxic, nonflammable, and inexpensive while also eliminating the use and disposal of potentially carcinogenic organic solvents. JF - Journal - Association of Official Analytical Chemists AU - Hopper, M L AU - King, J W AD - Food and Drug Administration, Total Diet Research Center, Kansas City, MO 64106. PY - 1991 SP - 661 EP - 666 VL - 74 IS - 4 SN - 0004-5756, 0004-5756 KW - Lipids KW - 0 KW - Pesticides KW - Water KW - 059QF0KO0R KW - Carbon Dioxide KW - 142M471B3J KW - Diatomaceous Earth KW - 61790-53-2 KW - Butter KW - 8029-34-3 KW - Index Medicus KW - Butter -- analysis KW - Meat -- analysis KW - Lipids -- analysis KW - Pesticides -- analysis KW - Food Analysis -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72138316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Enhanced+supercritical+fluid+carbon+dioxide+extraction+of+pesticides+from+foods+using+pelletized+diatomaceous+earth.&rft.au=Hopper%2C+M+L%3BKing%2C+J+W&rft.aulast=Hopper&rft.aufirst=M&rft.date=1991-07-01&rft.volume=74&rft.issue=4&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fumigation trends, fumigant analysis, and findings. AN - 72137982; 1917802 JF - Journal - Association of Official Analytical Chemists AU - Daft, J L AD - Food and Drug Administration, U.S. Department of Health and Human Service, Kansas City, MO 64106. PY - 1991 SP - 575 EP - 576 VL - 74 IS - 4 SN - 0004-5756, 0004-5756 KW - Index Medicus KW - Food Analysis -- methods KW - Food Contamination -- analysis KW - Fumigation -- methods KW - Fumigation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72137982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Fumigation+trends%2C+fumigant+analysis%2C+and+findings.&rft.au=Daft%2C+J+L&rft.aulast=Daft&rft.aufirst=J&rft.date=1991-07-01&rft.volume=74&rft.issue=4&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lipid globule staining to aid in differentiating Bacillus species. AN - 72136569; 1717433 AB - The use of the lipid globule stain to aid in differentiating the Bacillus cereus group (i.e., B. cereus, B. cereus var. mycoides, and B. thuringiensis) from other Bacillus species was investigated. Smears from colonies grown on suitable agar were made on precleaned slides, stained, and examined microscopically for characteristic deep blue lipid globules. The study included a total of 649 cultures of Bacillus species plus 143 incompletely characterized Bacillus isolates from food. Only B. cereus, B. cereus var. mycoides, B. thuringiensis, B. megaterium, and B. sphaericus were consistently positive for lipid globules, although at times, a few cells of B. aneurinolyticus and B. thiaminolyticus were also positive. The lipid globule stain procedure is of value in differentiating Bacillus species, especially when performed by an experienced analyst and used in conjunction with tests for cell and spore morphology. JF - Journal - Association of Official Analytical Chemists AU - Harmon, S M AU - Kautter, D A AU - Lancette, G AD - Food and Drug Administration, Division of Microbiology, Washington, DC 20204. PY - 1991 SP - 649 EP - 651 VL - 74 IS - 4 SN - 0004-5756, 0004-5756 KW - Index Medicus KW - Bacillus cereus -- classification KW - Food Microbiology KW - Staining and Labeling -- methods KW - Bacillus cereus -- metabolism KW - Bacillus -- metabolism KW - Bacillus -- classification KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72136569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Lipid+globule+staining+to+aid+in+differentiating+Bacillus+species.&rft.au=Harmon%2C+S+M%3BKautter%2C+D+A%3BLancette%2C+G&rft.aulast=Harmon&rft.aufirst=S&rft.date=1991-07-01&rft.volume=74&rft.issue=4&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Results from the American Society for Gastrointestinal Endoscopy/U.S. Food and Drug Administration collaborative study on complication rates and drug use during gastrointestinal endoscopy. AN - 72127858; 1833259 AB - We used data from the American Society for Gastrointestinal Endoscopy's computer-based management system to compare the rates of serious cardiorespiratory complications and death associated with the use of midazolam and diazepam. Data were analyzed from 21,011 procedures. Midazolam was used in 15,061 of these procedures, diazepam in 4,302, and neither in 1,648. We assessed benzodiazepine dose, concomitant drug administration, type of procedure, and selected patient characteristics in each of these three groups. No significant difference between these three groups were noted other than the fact that certain clinical centers tended to exclusively use midazolam, whereas others used both benzodiazepines. Reports of serious cardiorespiratory complications and death were uncommon, occurring in 5.4 and 0.3 per thousand procedures, respectively. Midazolam did not seem to place patients in this sample at greater risk for cardiorespiratory complications than diazepam. Concomitant use of narcotics and urgent and emergent procedures, however, did increase the risk of serious cardiorespiratory events. JF - Gastrointestinal endoscopy AU - Arrowsmith, J B AU - Gerstman, B B AU - Fleischer, D E AU - Benjamin, S B AD - U.S. Food and Drug Administration, Rockville, MD. PY - 1991 SP - 421 EP - 427 VL - 37 IS - 4 SN - 0016-5107, 0016-5107 KW - Diazepam KW - Q3JTX2Q7TU KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Injections, Intravenous KW - Heart Diseases -- chemically induced KW - Humans KW - Retrospective Studies KW - Conscious Sedation -- adverse effects KW - Respiration Disorders -- etiology KW - Aged KW - Respiration Disorders -- chemically induced KW - Laparoscopy -- adverse effects KW - Cholangiopancreatography, Endoscopic Retrograde -- adverse effects KW - Middle Aged KW - Heart Diseases -- etiology KW - Female KW - Male KW - Diazepam -- administration & dosage KW - Endoscopy, Gastrointestinal -- adverse effects KW - Midazolam -- administration & dosage KW - Diazepam -- adverse effects KW - Midazolam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72127858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastrointestinal+endoscopy&rft.atitle=Results+from+the+American+Society+for+Gastrointestinal+Endoscopy%2FU.S.+Food+and+Drug+Administration+collaborative+study+on+complication+rates+and+drug+use+during+gastrointestinal+endoscopy.&rft.au=Arrowsmith%2C+J+B%3BGerstman%2C+B+B%3BFleischer%2C+D+E%3BBenjamin%2C+S+B&rft.aulast=Arrowsmith&rft.aufirst=J&rft.date=1991-07-01&rft.volume=37&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Gastrointestinal+endoscopy&rft.issn=00165107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Lead exposure from conventional and cottage lead smelting in Jamaica. AN - 72118408; 1898119 AB - A survey was conducted to determine the distribution and determinants of environmental and blood lead levels near a conventional and several cottage lead smelters and to assess the relationship between environmental and blood lead levels in a tropical, developing-country setting. Fifty-eight households were studied in the Red Pond community, the site of the established smelter and several backyard smelters, and 21 households were studied in the adjacent, upwind Ebony Vale community in Saint Catherine Parish, Jamaica. Households were investigated, using questionnaires, soil and housedust lead measurements, and blood lead (PbB) measurements from 372 residents. Soil lead levels in Red Pond exceeded 500 parts per million (ppm) at 24% of households (maximum--18,600 ppm), compared to 0% in Ebony Vale (maximum 150 ppm). Geometric mean PbB in Red Pond, where 44% of children less than 6 years of age had PbB levels greater than or equal to 25 micrograms per deciliter (micrograms/dL), was more than twice that Ebony Vale in all age groups (p less than 0.0005). Within Red Pond, proximity to backyard smelters and to the conventional smelter were independent predictors of soil lead (p less than 0.05). Soil lead was the strongest predictor of PbB among Red Pond subjects under 12 years of age. The blood lead--soil lead relationship in children differed from that reported in developed countries; blood lead levels were higher than expected for the household-specific soil lead levels that were observed.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Archives of environmental contamination and toxicology AU - Matte, T D AU - Figueroa, J P AU - Ostrowski, S AU - Burr, G AU - Jackson-Hunt, L AU - Baker, E L AD - Office of the Director, National Institute for Occupational Safety and Health Centers for Disease Control, Atlanta, Georgia 30333. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 65 EP - 71 VL - 21 IS - 1 SN - 0090-4341, 0090-4341 KW - Dust KW - 0 KW - Soil KW - Soil Pollutants KW - Lead KW - 2P299V784P KW - Index Medicus KW - Infant KW - Humans KW - Developing Countries KW - Child KW - Jamaica KW - Tropical Climate KW - Child, Preschool KW - Dust -- analysis KW - Soil -- analysis KW - Soil Pollutants -- blood KW - Lead -- analysis KW - Metallurgy KW - Lead -- blood KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72118408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+contamination+and+toxicology&rft.atitle=Lead+exposure+from+conventional+and+cottage+lead+smelting+in+Jamaica.&rft.au=Matte%2C+T+D%3BFigueroa%2C+J+P%3BOstrowski%2C+S%3BBurr%2C+G%3BJackson-Hunt%2C+L%3BBaker%2C+E+L&rft.aulast=Matte&rft.aufirst=T&rft.date=1991-07-01&rft.volume=21&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+contamination+and+toxicology&rft.issn=00904341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-23 N1 - Date created - 1991-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Statistical model in tests for eye irritants. AN - 72101705; 1894212 AB - A test used to classify substances for eye irritancy, as required by the Consumer Product Safety Commission, is performed on 1-3 groups of 6 albino rabbits in a sequential manner. When the statistical implications of the test are realized, it is possible for a substance to be classified as an irritant with fewer reactions than the number required for it to be classified as not an irritant. A procedure is given for correcting the inconsistency in the current test, and an alternative test, which considerably reduces the number of animals required, is proposed. Probability models and expected sample size calculations have been derived. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Roberts, C D AD - Division of Mathematics, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 463 EP - 468 VL - 29 IS - 7 SN - 0278-6915, 0278-6915 KW - Irritants KW - 0 KW - Index Medicus KW - Probability KW - Animals KW - Rabbits KW - Animal Testing Alternatives KW - Animal Welfare KW - Models, Statistical KW - Eye -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72101705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Statistical+model+in+tests+for+eye+irritants.&rft.au=Roberts%2C+C+D&rft.aulast=Roberts&rft.aufirst=C&rft.date=1991-07-01&rft.volume=29&rft.issue=7&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-22 N1 - Date created - 1991-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of dietary soya bean trypsin inhibitor concentrate on initiation and growth of putative preneoplastic lesions in the pancreas of the rat. AN - 72099020; 1894210 AB - Two studies evaluated the effects of soya bean trypsin inhibitor concentrate (STIC) on early stages of pancreatic carcinogenesis in Wistar rats. In experiment 1, the effects of a 3-month administration of diets containing 3.7% STIC were compared with the effects of administration of diets containing 20% corn oil, in rats pretreated with a single azaserine injection sufficient to initiate putative preneoplastic atypical acinar cell foci. Experiment 2 investigated the capacity of STIC to initiate pancreatic carcinogenesis. Diets containing 3.7% STIC were fed for 4 wk, then diets containing either 5 or 20% corn oil were fed for 3 months. Pancreases were quantitatively evaluated for foci. All groups of azaserine-initiated rats had large numbers of atypical acinar cell foci per cm3 of pancreas. Of these, the group fed 3.7% STIC had pancreatic foci that occupied a significantly greater (P less than 0.01) percentage volume of pancreas than did groups fed 20% corn oil or control diets, which contained 5% corn oil and no added trypsin inhibitor. Very few or no foci were observed in all other groups of either experiment 1 or 2. STIC had a much greater effect on the growth of azaserine-induced lesions than did corn oil. STIC alone did not appear to initiate pancreatic lesions. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Myers, B A AU - Hathcock, J AU - Shiekh, N AU - Roebuck, B D AD - Division of Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 437 EP - 443 VL - 29 IS - 7 SN - 0278-6915, 0278-6915 KW - Trypsin Inhibitors KW - 0 KW - Corn Oil KW - 8001-30-7 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Pancreas -- pathology KW - Eating -- drug effects KW - Animals KW - Body Weight -- drug effects KW - Pancreas -- growth & development KW - Pancreas -- drug effects KW - Corn Oil -- administration & dosage KW - Male KW - Organ Size -- drug effects KW - Precancerous Conditions -- chemically induced KW - Pancreatic Neoplasms -- chemically induced KW - Trypsin Inhibitors -- toxicity KW - Soybeans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72099020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Effects+of+dietary+soya+bean+trypsin+inhibitor+concentrate+on+initiation+and+growth+of+putative+preneoplastic+lesions+in+the+pancreas+of+the+rat.&rft.au=Myers%2C+B+A%3BHathcock%2C+J%3BShiekh%2C+N%3BRoebuck%2C+B+D&rft.aulast=Myers&rft.aufirst=B&rft.date=1991-07-01&rft.volume=29&rft.issue=7&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-22 N1 - Date created - 1991-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Followup study of possible HIV seropositivity among abusers of parenteral drugs in 1971-72. AN - 72051691; 1908596 AB - Serum specimens obtained from a nationwide sample of parenteral drug abusers (PDAs) during the period 1971-72 had previously been screened for human immunodeficiency virus (HIV) antibodies. Some specimens were considered to be positive to both ELISA and Western blot (WB) analysis. These findings have been a topic of controversy, since HIV was not thought to have penetrated at-risk populations at such an early date. This study was a followup of those PDAs with apparent seropositivity to WB analysis. Of 10 persons followed, only one death (in 1985) was documented, and postmortem findings were inconsistent with HIV infection. Eight of the remaining PDAs were traced and found to be alive and well in 1989. Fresh specimens were obtained from the two persons with the strongest 1971-72 WB staining and were found to be both ELISA and WB negative on retesting. Their T-cell parameters were within normal limits. We concluded that the earlier WB results were most likely false positives and that definitive evidence of HIV infection in the U.S. addict population as early as 1971-72 is still lacking. JF - Public health reports (Washington, D.C. : 1974) AU - Lange, W R AU - Ball, J C AU - Adler, W H AU - Brown, E AU - Pyle, R AU - Hoffman, W AU - Dax, E M AD - Public Health Service, National Institute on Drug Abuse's Addiction Research Center, Baltimore, MD 21224. PY - 1991 SP - 451 EP - 455 VL - 106 IS - 4 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Mortality KW - Blotting, Western KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Follow-Up Studies KW - T-Lymphocyte Subsets -- chemistry KW - Male KW - Female KW - Cross Reactions KW - Population Surveillance KW - Kentucky -- epidemiology KW - False Positive Reactions KW - Substance Abuse, Intravenous -- complications KW - HIV Seropositivity -- immunology KW - HIV Seropositivity -- epidemiology KW - HIV Seropositivity -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72051691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Followup+study+of+possible+HIV+seropositivity+among+abusers+of+parenteral+drugs+in+1971-72.&rft.au=Lange%2C+W+R%3BBall%2C+J+C%3BAdler%2C+W+H%3BBrown%2C+E%3BPyle%2C+R%3BHoffman%2C+W%3BDax%2C+E+M&rft.aulast=Lange&rft.aufirst=W&rft.date=1991-07-01&rft.volume=106&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-20 N1 - Date created - 1991-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Transfusion. 1988 Sep-Oct;28(5):412-8 [3420668] JAMA. 1984 Sep 7;252(9):1152-9 [6471338] Int J Addict. 1989 Jul;24(7):609-26 [2599682] Rev Infect Dis. 1987 Nov-Dec;9(6):1102-8 [3321360] Ann Intern Med. 1985 Nov;103(5):755-9 [4051350] N Engl J Med. 1986 May 22;314(21):1387-8 [3010112] J Infect Dis. 1986 Apr;153(4):736-42 [3005434] Anal Biochem. 1988 May 15;171(1):1-32 [3044183] Ann Intern Med. 1988 Jun;108(6):785-90 [3285743] Mayo Clin Proc. 1989 Oct;64(10):1226-34 [2593713] South Med J. 1989 Sep;82(9):1075-8 [2772675] Ann Intern Med. 1987 May;106(5):671-6 [3551711] Am J Med. 1984 Mar;76(3):493-500 [6322585] J Infect Dis. 1983 Aug;148(2):339-45 [6604115] Clin Exp Immunol. 1983 Aug;53(2):465-72 [6224612] Immunol Commun. 1983;12(2):223-237 [6603416] JAMA. 1988 Oct 14;260(14):2085-7 [3418874] N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - AIDS in U.S. hospitals, 1986-1987: a national perspective T2 - AHCPR pubn. no. 91-0015 Hospital studies program research note 15 AN - 59576677; 1991-1509670 AB - Examines inpatient care based on individual discharges. Profiles variations across geographic regions of the US in hospital resource use and financing, as well as patient characteristics, such as severity of illness, that contribute to variations in resource use. JF - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, July 1991. 21 pp. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 21 PB - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - Hospitals -- United States -- Statistics KW - United States -- Medical sector KW - Terminally ill -- Care and treatment KW - Acquired immune deficiency syndrome -- United States -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59576677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=AIDS+in+U.S.+hospitals%2C+1986-1987%3A+a+national+perspective&rft.title=AIDS+in+U.S.+hospitals%2C+1986-1987%3A+a+national+perspective&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 N1 - Document feature - bibl(s), table(s), chart(s), map(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct. AN - 80626226; 2052611 AB - The prevalence of covalent modifications to DNA (carcinogen-DNA adducts) in 42 human urinary bladder biopsy samples was investigated by 32P-postlabeling methods, with enhancement by both nuclease P1 treatment and 1-butanol extraction. Total mean carcinogen-DNA adduct levels and the mean levels of several specific adducts were significantly elevated in DNA samples of 13 current smokers, as opposed to 9 never smokers or 20 ex-smokers (5 years abstinence). There was no significant difference between the latter two groups. Several DNA adducts enhanced by nuclease P1 treatment were chromatographically similar to putative hydrocarbon DNA adducts reported earlier for placenta and lung DNA samples obtained from cigarette smokers. Putative aromatic amine adducts were detected by 1-butanol extraction that were not present when the samples were treated with nuclease P1. One of these displayed chromatographic behavior identical to the predominant adduct induced by the human urinary bladder carcinogen, 4-aminobiphenyl, which is present in cigarette smoke. This adduct comigrated in several thin-layer chromatographic systems with a synthetic N-(deoxyguanosin-8-yl)-4-amino[2,2'-3H]biphenyl-3',5'-bisphosphate marker. Moreover, when this adduct was eluted from the thin-layer chromatograms of several individuals and injected onto an HPLC system, the 32P from the human bladder DNA samples coeluted in the same fraction as the tritiated synthetic N-(deoxyguanosin-8-yl)-4-aminobiphenyl marker. These data reinforce an association between cigarette smoking and DNA damage and suggest a molecular basis for the initiation of human urinary bladder cancer by cigarette smoke. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Talaska, G AU - al-Juburi, A Z AU - Kadlubar, F F AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/06/15/ PY - 1991 DA - 1991 Jun 15 SP - 5350 EP - 5354 VL - 88 IS - 12 SN - 0027-8424, 0027-8424 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - N-(deoxyguanosin-8-yl)-4-aminobiphenyl KW - 86408-34-6 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Chromatography, Thin Layer KW - Autoradiography KW - Male KW - Chromatography, High Pressure Liquid KW - Smoking -- urine KW - Aminobiphenyl Compounds -- chemistry KW - DNA Damage KW - Urinary Bladder -- chemistry KW - Deoxyguanosine -- chemistry KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80626226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Smoking+related+carcinogen-DNA+adducts+in+biopsy+samples+of+human+urinary+bladder%3A+identification+of+N-%28deoxyguanosin-8-yl%29-4-aminobiphenyl+as+a+major+adduct.&rft.au=Talaska%2C+G%3Bal-Juburi%2C+A+Z%3BKadlubar%2C+F+F&rft.aulast=Talaska&rft.aufirst=G&rft.date=1991-06-15&rft.volume=88&rft.issue=12&rft.spage=5350&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-19 N1 - Date created - 1991-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1981 Oct;78(10):6126-9 [7031643] Prog Clin Biol Res. 1990;340B:107-14 [2392442] Carcinogenesis. 1983;4(3):335-8 [6831638] Proc Natl Acad Sci U S A. 1984 Nov;81(22):6943-7 [6594673] Appl Environ Microbiol. 1985 Jul;50(1):10-5 [4026284] Cancer Res. 1985 Nov;45(11 Pt 2):5656-62 [4053037] Science. 1986 Jan 3;231(4733):54-7 [3941892] Cancer Res. 1986 Jun;46(6):3046-54 [3698023] Carcinogenesis. 1986 Sep;7(9):1543-51 [3017601] Carcinogenesis. 1986 Sep;7(9):1615-7 [3742734] Cancer Res. 1987 Jan 15;47(2):602-8 [3791245] Carcinogenesis. 1987 Apr;8(4):515-20 [3549038] Biochemistry. 1987 Jun 2;26(11):3072-81 [3300770] Carcinogenesis. 1987 Dec;8(12):1899-905 [3677313] Carcinogenesis. 1988 Sep;9(9):1687-93 [3409474] Acta Oncol. 1988;27(4):323-7 [3202992] Nature. 1988 Dec 22-29;336(6201):790-2 [3205307] Mutat Res. 1989 Mar;219(2):121-33 [2927417] Cancer Lett. 1989 Apr;45(1):7-12 [2540901] Am J Public Health. 1989 Oct;79(10):1381-4 [2782507] Proc Natl Acad Sci U S A. 1989 Oct;86(20):7696-700 [2813353] Carcinogenesis. 1990 Feb;11(2):205-11 [2105856] Carcinogenesis. 1990 Apr;11(4):639-46 [2323002] Int J Cancer. 1990 Apr 15;45(4):673-8 [2323844] Cancer Res. 1990 May 15;50(10):3002-4 [2334904] Carcinogenesis. 1982;3(9):1081-92 [7139866] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei. AN - 80615045; 2049786 AB - The extent of lipid peroxidation and DNA damage induced by quercetin were studied under aerobic conditions in isolated rat-liver nuclei. The effects of iron and copper ions on these two toxic oxidative processes were also investigated. Quercetin induced significant (P less than 0.05) concentration-dependent nuclear lipid peroxidation concurrent with DNA degradation; these effects were enhanced by iron and copper ions. The results suggest that the reactive oxygen species generated by quercetin autoxidation, catalyzed by iron and copper ions, are responsible for the concurrent lipid peroxidation and DNA damage in isolated rat-liver nuclei. JF - Cancer letters AU - Sahu, S C AU - Washington, M C AD - Molecular Toxicology Laboratory, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/06/14/ PY - 1991 DA - 1991 Jun 14 SP - 75 EP - 79 VL - 58 IS - 1-2 SN - 0304-3835, 0304-3835 KW - Carcinogens KW - 0 KW - Free Radicals KW - Copper KW - 789U1901C5 KW - Quercetin KW - 9IKM0I5T1E KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Iron -- pharmacology KW - Cell Nucleus -- metabolism KW - Cell Nucleus -- drug effects KW - Diet KW - Copper -- pharmacology KW - Male KW - Quercetin -- administration & dosage KW - Liver -- drug effects KW - DNA Damage KW - Liver -- metabolism KW - Lipid Peroxidation KW - Quercetin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80615045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Quercetin-induced+lipid+peroxidation+and+DNA+damage+in+isolated+rat-liver+nuclei.&rft.au=Sahu%2C+S+C%3BWashington%2C+M+C&rft.aulast=Sahu&rft.aufirst=S&rft.date=1991-06-14&rft.volume=58&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-24 N1 - Date created - 1991-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Assistant Secretary for Health, US Public Health Service. AN - 80571960; 2033755 JF - JAMA AU - Mason, J O AD - Public Health Service, Washington, DC 20201. Y1 - 1991/06/12/ PY - 1991 DA - 1991 Jun 12 SP - 2939 VL - 265 IS - 22 SN - 0098-7484, 0098-7484 KW - Fluorides KW - Q80VPU408O KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Public Health Service KW - Fluoridation KW - Humans KW - Child KW - Fluorides -- adverse effects KW - Fluorosis, Dental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80571960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Assistant+Secretary+for+Health%2C+US+Public+Health+Service.&rft.au=Mason%2C+J+O&rft.aulast=Mason&rft.aufirst=J&rft.date=1991-06-12&rft.volume=265&rft.issue=22&rft.spage=2939&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-27 N1 - Date created - 1991-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Standardized tests and measures for assessing low-back pain in the occupational setting. A developmental model. AN - 80716828; 1830696 JF - Spine AU - Nelson, R M AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 679 EP - 681 VL - 16 IS - 6 SN - 0362-2436, 0362-2436 KW - Index Medicus KW - Exercise Test KW - Risk Factors KW - Humans KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Physical Examination KW - Occupational Diseases -- diagnosis KW - Back Pain -- epidemiology KW - Back Pain -- diagnosis KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80716828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Spine&rft.atitle=Standardized+tests+and+measures+for+assessing+low-back+pain+in+the+occupational+setting.+A+developmental+model.&rft.au=Nelson%2C+R+M&rft.aulast=Nelson&rft.aufirst=R&rft.date=1991-06-01&rft.volume=16&rft.issue=6&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Spine&rft.issn=03622436&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-05 N1 - Date created - 1991-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation. AN - 80612865; 2046705 AB - The antihistamine methapyrilene hydrochloride has been shown to be a potent hepatocarcinogen in Fischer 344 rats. It has also been evaluated in a number of short-term in vivo and in vitro genotoxicity assays with conflicting results. We studied its ability to form DNA adducts in the L5178Y/TK+/- mouse lymphoma cells, an assay system in which methapyrilene is a moderately active mutagen and appears to induce mutations predominantly of chromosomal origin. Methapyrilene failed to induce formation of DNA adducts in L5178Y cell DNA at doses which induced mutations at the thymidine kinase locus. These data suggest that methapyrilene induces mutations in this system through an indirect genotoxic mechanism; e.g., via an oxidative mechanism or interaction with chromosomal proteins. JF - Mutation research AU - Casciano, D A AU - Talaska, G AU - Clive, D AD - National Center for Toxicological Research, Division of Genetic Toxicology, Jefferson, AR 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 127 EP - 132 VL - 263 IS - 2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Mutagens KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Methapyrilene KW - A01LX40298 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Animals KW - Tumor Cells, Cultured KW - 2-Acetylaminofluorene -- pharmacology KW - Chromosome Aberrations KW - Mice KW - Colony-Forming Units Assay KW - DNA Damage KW - Methapyrilene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80612865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+potent+hepatocarcinogen+methapyrilene+induces+mutations+in+L5178Y+mouse+lymphoma+cells+in+the+apparent+absence+of+DNA+adduct+formation.&rft.au=Casciano%2C+D+A%3BTalaska%2C+G%3BClive%2C+D&rft.aulast=Casciano&rft.aufirst=D&rft.date=1991-06-01&rft.volume=263&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-16 N1 - Date created - 1991-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes in forced expiratory volume in one second and peak expiratory flow rate across a work shift among unexposed blue collar workers. AN - 80609897; 2048805 AB - Pre- and postshift spirometry was obtained on 1,113 blue collar workers employed at 35 work sites judged to have no hazardous occupational respiratory exposures on the basis of inspection visits and environmental sampling. In addition to spirometry, a standardized questionnaire was administered by trained personnel. A study population of 944 remained after exclusion of workers for incomplete demographic data and/or spirometry with poor within-session reproducibility, i.e., greater than or equal to 10% variability in the two largest values of either FVC and/or FEV1. Overall mean values of changes across the work shift in FEV1 and peak expiratory flow rate (PEFR) were -0.8% (-0.04 L) and +2.1% (+0.13 L/s), respectively. Standard deviations for these across-shift changes were 5.8% (0.19 L) and 13.2% (1.19 L/s) for FEV1 and PEFR, respectively. In univariate analyses, mean values of across-shift changes were not statistically related to age, race, sex, smoking status, work shift, or FEV1/FVC ratio. However, variability (i.e., standard deviation) of across-shift changes were significantly related to some of these factors. These observations provide a basis for interpreting results of occupational respiratory morbidity surveys involving measurement of changes in FEV1 and/or PEFR across a work shift. JF - The American review of respiratory disease AU - Ghio, A J AU - Castellan, R M AU - Kinsley, K B AU - Hankinson, J L AD - Clinical Investigations Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 1231 EP - 1234 VL - 143 IS - 6 SN - 0003-0805, 0003-0805 KW - Abridged Index Medicus KW - Index Medicus KW - Reference Values KW - Vital Capacity KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Time Factors KW - Peak Expiratory Flow Rate KW - Environmental Exposure KW - Forced Expiratory Volume KW - Occupational Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80609897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Changes+in+forced+expiratory+volume+in+one+second+and+peak+expiratory+flow+rate+across+a+work+shift+among+unexposed+blue+collar+workers.&rft.au=Ghio%2C+A+J%3BCastellan%2C+R+M%3BKinsley%2C+K+B%3BHankinson%2C+J+L&rft.aulast=Ghio&rft.aufirst=A&rft.date=1991-06-01&rft.volume=143&rft.issue=6&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-12 N1 - Date created - 1991-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational exposure to radon daughters in Mammoth Cave National Park. AN - 80560794; 1851736 JF - Health physics AU - Eheman, C AU - Carson, B AU - Rifenburg, J AU - Hoffman, D AD - Radiation Studies Branch, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 831 EP - 835 VL - 60 IS - 6 SN - 0017-9078, 0017-9078 KW - Radon Daughters KW - 0 KW - Lead KW - 2P299V784P KW - Polonium KW - DQY03U61EJ KW - Bismuth KW - U015TT5I8H KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Kentucky KW - Male KW - Female KW - Occupational Exposure KW - Polonium -- analysis KW - Mining KW - Bismuth -- analysis KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80560794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Occupational+exposure+to+radon+daughters+in+Mammoth+Cave+National+Park.&rft.au=Eheman%2C+C%3BCarson%2C+B%3BRifenburg%2C+J%3BHoffman%2C+D&rft.aulast=Eheman&rft.aufirst=C&rft.date=1991-06-01&rft.volume=60&rft.issue=6&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-24 N1 - Date created - 1991-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Agricultural machine-related deaths. AN - 80559022; 2029052 AB - Analysis of 1980-1985 death certificate data for the United States indicated that an average of 369 occupational deaths per year involved agricultural machinery as the external cause of death. Out of all agricultural machine-related deaths, tractors accounted for 69 percent. Over half of these tractor-related deaths were rollovers. There is a need for public health programs to affect greater use of rollover protective structures (ROPS) on farm tractors. JF - American journal of public health AU - Etherton, J R AU - Myers, J R AU - Jensen, R C AU - Russell, J C AU - Braddee, R W AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 766 EP - 768 VL - 81 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Death Certificates KW - Databases, Factual KW - United States Occupational Safety and Health Administration KW - Accident Prevention KW - United States -- epidemiology KW - Cause of Death KW - Accidents, Occupational -- prevention & control KW - Accidents, Occupational -- classification KW - Agriculture -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80559022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Agricultural+machine-related+deaths.&rft.au=Etherton%2C+J+R%3BMyers%2C+J+R%3BJensen%2C+R+C%3BRussell%2C+J+C%3BBraddee%2C+R+W&rft.aulast=Etherton&rft.aufirst=J&rft.date=1991-06-01&rft.volume=81&rft.issue=6&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1979 Feb;69(2):146-9 [760571] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Public Health Rep. 1985 May-Jun;100(3):329-33 [3923543] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Female homicides in United States workplaces, 1980-1985. AN - 80558429; 2029041 AB - Women, while noted for low occupational injury mortality rates, are more likely to die as victims of assault than from any other manner of injury at work. From the National Traumatic Occupational Fatality surveillance data, 950 women were identified who were fatally assaulted at work. Homicide rates were calculated for the demographic and employment characteristics of these women. Risk ratios among types of lethal injuries were examined. During 1980-1985, the crude six-year workplace homicide rate was 4.0 deaths per million working women: one twentieth the homicide rate of the US female population. Decedents ranged from 16 years (the lowest age included in the data base) to 93 years of age. Working women older than 65 years had the highest age-specific homicide rate, 11.3 per million. Women younger than 20 had the lowest, 2.5 per million per year. Homicide rates for women of races other than White were nearly twice as high as those of Whites. The leading causes of death were gunshot wounds (64 percent), stabbings (19 percent), asphyxiations (7 percent), and blunt force trauma (6 percent). Nearly 43 percent of the deceased women had been employed in retail trade: 8.7 per million employed women annually. During 1980-1985, only 6 percent of the nation's victims of work-related injury deaths were female: 41 percent of those women were murdered. Homicide is currently the leading manner of traumatic workplace death among women in the United States. JF - American journal of public health AU - Bell, C A AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 729 EP - 732 VL - 81 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Sex Factors KW - Humans KW - Aged KW - Cause of Death KW - Population Surveillance KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Death Certificates KW - Databases, Factual KW - United States Occupational Safety and Health Administration KW - Middle Aged KW - Adolescent KW - Occupations KW - United States -- epidemiology KW - Female KW - Industry KW - Homicide -- classification KW - Homicide -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80558429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Female+homicides+in+United+States+workplaces%2C+1980-1985.&rft.au=Bell%2C+C+A&rft.aulast=Bell&rft.aufirst=C&rft.date=1991-06-01&rft.volume=81&rft.issue=6&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1982 Aug 13;248(6):692-7 [7097919] N Engl J Med. 1985 Nov 14;313(20):1263-9 [4058507] Am J Public Health. 1987 Oct;77(10):1285-9 [3631361] Am J Public Health. 1987 Oct;77(10):1290-3 [3631362] Am J Public Health. 1987 Dec;77(12):1524-7 [3674251] Am J Public Health. 1991 Jun;81(6):725-8 [1827569] J Occup Med. 1988 Jun;30(6):483-7 [3392614] Am J Public Health. 1988 Dec;78(12):1579-81 [3189637] Am J Ind Med. 1988;14(2):121-36 [3207099] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Am J Public Health. 1987 Dec;77(12):1532-4 [3674253] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effectiveness of source documents for identifying fatal occupational injuries: a synthesis of studies. AN - 80556173; 1827569 AB - The complete and accurate identification of fatal occupational injuries among the US work force is an important first step in developing work injury prevention efforts. Numerous sources of information, such as death certificates, Workers' Compensation files, Occupational Safety and Health Administration (OSHA) files, medical examiner records, state health and labor department reports, and various combinations of these, have been used to identify cases of work-related fatal injuries. Recent studies have questioned the effectiveness of these sources for identifying such cases. At least 10 studies have used multiple sources to define the universe of fatal work injuries within a state and to determine the capture rates, or proportion of the universe identified, by each source. Results of these studies, which are not all available in published literature, are summarized here in a format that allows researchers to readily compare the ascertainment capabilities of the sources. The overall average capture rates of sources were as follows: death certificates, 81%; medical examiner records, 61%; Workers' Compensation reports, 57%; and OSHA reports 32%. Variations by state and value added through the use of multiple sources are presented and discussed. This meta-analysis of 10 state-based studies summarizes the effectiveness of various source documents for capturing cases of fatal occupational injuries to help researchers make informed decisions when designing occupational injury surveillance systems. JF - American journal of public health AU - Stout, N AU - Bell, C AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 725 EP - 728 VL - 81 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Evaluation Studies as Topic KW - Coroners and Medical Examiners KW - Humans KW - State Health Planning and Development Agencies KW - Death Certificates KW - Workers' Compensation KW - United States Occupational Safety and Health Administration KW - Meta-Analysis as Topic KW - Population Surveillance -- methods KW - Data Collection -- standards KW - Data Collection -- methods KW - Accidents, Occupational -- mortality KW - Documentation -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80556173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Effectiveness+of+source+documents+for+identifying+fatal+occupational+injuries%3A+a+synthesis+of+studies.&rft.au=Stout%2C+N%3BBell%2C+C&rft.aulast=Stout&rft.aufirst=N&rft.date=1991-06-01&rft.volume=81&rft.issue=6&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1988 Sep;78(9):1218-9 [3407825] Am J Public Health. 1988 Sep;78(9):1215-7 [3407824] Am J Ind Med. 1989;15(6):669-78 [2750742] J Occup Med. 1988 Nov;30(11):868-72 [3230433] JAMA. 1982 Aug 13;248(6):692-7 [7097919] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Am J Public Health. 1990 Feb;80(2):200-2 [2297066] Am J Public Health. 1990 Feb;80(2):198-200 [2297065] J Occup Med. 1986 Feb;28(2):100-2 [3754006] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biomarkers of aging: an overview. AN - 72116857; 1910590 JF - Biomedical and environmental sciences : BES AU - Turturro, A AU - Hart, R W AD - National Center for Toxicological Research, Jefferson, Akansas 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 130 EP - 133 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Hazardous Substances KW - Index Medicus KW - Disease Susceptibility KW - DNA Damage KW - Humans KW - Aging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72116857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biomarkers+of+aging%3A+an+overview.&rft.au=Turturro%2C+A%3BHart%2C+R+W&rft.aulast=Turturro&rft.aufirst=A&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biomarkers of human exposure to carcinogens: an overview. AN - 72116629; 1910602 JF - Biomedical and environmental sciences : BES AU - Beland, F A AU - Poirier, M C AD - National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 69 EP - 72 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Carcinogens KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Humans KW - Neoplasms -- chemically induced KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72116629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biomarkers+of+human+exposure+to+carcinogens%3A+an+overview.&rft.au=Beland%2C+F+A%3BPoirier%2C+M+C&rft.aulast=Beland&rft.aufirst=F&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biomarkers of neurotoxicity: an overview. AN - 72114392; 1910595 JF - Biomedical and environmental sciences : BES AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 192 EP - 196 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72114392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biomarkers+of+neurotoxicity%3A+an+overview.&rft.au=Slikker%2C+W&rft.aulast=Slikker&rft.aufirst=W&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biogenic amines as biomarkers for neurotoxicity. AN - 72113770; 1680343 AB - There has been a surge of interest over the past several years in the use of neurochemical endpoints to contribute to our understanding of the mechanism of action of neurotoxicants. In our present presentation, two biogenic amine systems were selected as examples of biomarkers for neurotoxicity. To investigate these neurochemical endpoints, two prototype neurotoxicants were evaluated in experimental animals. One agent, reserpine, was used to assess developmental neurotoxicity and administered prenatally, while the other, MDMA, was used in the adult animal. The neurochemical biomarkers measured were dopamine, serotonin, and their metabolite (DOPAC and 5-HIAA) concentrations by HPLC/EC and dopamine receptor binding by radioligand receptor techniques. A review of the background, experimental design, and results are presented in this article. Our findings indicate that components of the biogenic amine systems can be used as sensitive neurochemical biomarkers of neurotoxicity. These neurochemical biomarkers can be correlated with neuropathological and behavioral biomarkers to aid in the understanding of mechanisms of neurotoxicity. JF - Biomedical and environmental sciences : BES AU - Ali, S F AU - Chang, L W AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 207 EP - 216 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biogenic Amines KW - 0 KW - Biomarkers KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Reserpine KW - 8B1QWR724A KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Animals KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - Reserpine -- toxicity KW - 3,4-Methylenedioxyamphetamine -- toxicity KW - Female KW - Biogenic Amines -- metabolism KW - Nervous System -- drug effects KW - Nervous System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biogenic+amines+as+biomarkers+for+neurotoxicity.&rft.au=Ali%2C+S+F%3BChang%2C+L+W%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recent advances in biomarker research. Introduction. AN - 72113734; 1910597 JF - Biomedical and environmental sciences : BES AU - Hart, R W AU - Chang, L W AU - Turturro, A AU - Kadlubar, F F AD - DHHS/PHS/FDA, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 2 EP - 7 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - Animals KW - Disease Susceptibility KW - Humans KW - Environmental Pollutants -- toxicity KW - Environmental Pollutants -- economics KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Recent+advances+in+biomarker+research.+Introduction.&rft.au=Hart%2C+R+W%3BChang%2C+L+W%3BTurturro%2C+A%3BKadlubar%2C+F+F&rft.aulast=Hart&rft.aufirst=R&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Critical considerations in the immunochemical detection and quantitation of antigenic biomarkers. AN - 72113703; 1910589 AB - The formation of covalent adducts as a result of the interaction of metabolically activated chemicals with host macromolecules is a common critical event in mutagenic, carcinogenic, and immunologic phenomena. Because of their antigenicity and their immunogenicity, covalent adducts may be detected using sensitive immunochemical techniques. The immunochemical approaches to biomonitoring and molecular dosimetry of DNA damage are particularly attractive because they allow sensitive quantitation of specific DNA adducts present in small samples and do not rely on the use of radiolabeled adducts. Two examples of biomarker immunoassay development are presented: an avidin/biotin-amplified ELISA for the major DNA adduct of the human bladder carcinogen 4-aminobiphenyl (ABP), and a particle concentration fluorescent immunoassay (PCFIA) for the major protein adduct associated with toxicity by the prototype hepatotoxin acetaminophen. The examples illustrate critical steps in the development of biomarker immunoassays which include selection of the relevant adduct, preparation of an appropriate immunogen, immunization, characterization of antisera, and development of application-specific sample processing techniques for biomarker quantitation. Immunochemical procedures may be combined with other analytical techniques to form hybrid systems which take advantage of both the antigenicity and the physical or chemical properties of a biomarker to achieve greater specificity and/or sensitivity. The future usefulness of these new tools of molecular epidemiology will depend on a compound-by-compound validation of methods and critical evaluation of the biologic importance of the particular antigenic biomarker as an indicator of exposure and as an indicator of risk. JF - Biomedical and environmental sciences : BES AU - Roberts, D W AU - Benson, R W AU - Hinson, J A AU - Kadlubar, F F AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 113 EP - 129 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Aminobiphenyl Compounds KW - 0 KW - Antigens KW - Biomarkers KW - Carcinogens KW - 4-biphenylamine KW - 16054949HJ KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Sensitivity and Specificity KW - Carcinogens -- metabolism KW - Aminobiphenyl Compounds -- toxicity KW - DNA Damage KW - Humans KW - Acetaminophen -- metabolism KW - Aminobiphenyl Compounds -- metabolism KW - Acetaminophen -- toxicity KW - Immunoassay KW - Immunochemistry -- methods KW - Antigens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Critical+considerations+in+the+immunochemical+detection+and+quantitation+of+antigenic+biomarkers.&rft.au=Roberts%2C+D+W%3BBenson%2C+R+W%3BHinson%2C+J+A%3BKadlubar%2C+F+F&rft.aulast=Roberts&rft.aufirst=D&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of dietary restriction and aging on in vivo and in vitro binding of aflatoxin B1 to cellular DNA. AN - 72112798; 1910591 AB - Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary restriction on laboratory animals have been suggested to be related to a deceleration of the aging process. The inhibition of age-related changes in xenobiotic metabolizing enzymes activities by dietary restriction has previously been reported. Alterations of these enzyme activities may cause changes in metabolic activation of carcinogens and, therefore, carcinogen-DNA binding. DNA-repair capability has also been reported to be enhanced in diet-restricted rats. Using AFB1 as a model carcinogen, we have studied in vivo and in vitro hepatic AFB1-DNA binding, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1, and subsequently reduce AFB1-DNA binding. Our preliminary results obtained from the AFB1-DNA binding experiments in isolated hepatocytes suggest that the observed age-dependent reduction in AFB1-DNA binding which may be attributed to a loss of metabolic activating capability was delayed in the diet-restricted rats. JF - Biomedical and environmental sciences : BES AU - Chou, M W AU - Pegram, R A AU - Gao, P AU - Hansard, S R AU - Shaddock, J G AU - Casciano, D A AD - National Center for Toxicological Research, Jefferson, Arkansas, AR 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 134 EP - 143 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Xenobiotics KW - 0 KW - DNA KW - 9007-49-2 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Liver -- drug effects KW - Biotransformation KW - Xenobiotics -- metabolism KW - Aging -- metabolism KW - Aflatoxin B1 -- metabolism KW - Aflatoxin B1 -- pharmacokinetics KW - DNA -- metabolism KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72112798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=The+effects+of+dietary+restriction+and+aging+on+in+vivo+and+in+vitro+binding+of+aflatoxin+B1+to+cellular+DNA.&rft.au=Chou%2C+M+W%3BPegram%2C+R+A%3BGao%2C+P%3BHansard%2C+S+R%3BShaddock%2C+J+G%3BCasciano%2C+D+A&rft.aulast=Chou&rft.aufirst=M&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of trimethyltin on amino acid concentrations in different regions of the mouse brain. AN - 72090697; 1891440 AB - Trimethyltin (TMT) is a neurotoxic compound known to cause marked alterations in brain chemistry. We have previously demonstrated that a single oral dose of TMT produced a dose-dependent decrease in muscarinic cholinergic receptors in mouse brain and significantly elevated glutamine in several regions of the rat brain. This study was designed to determine if TMT produced dose- and time-related alterations in amino acid concentrations in the adult male C57BL/6N mouse brain and in peripheral organs and plasma. In the dose-response study, TMT was administered orally as a single dose of 0, 0.5, 1.0, 3.0 or 5.0 mg/kg and animals were sacrificed 24 hr after treatment. In the time-course study, mice were dosed with TMT at 3.0 mg/kg and sacrificed 4, 12, 24, 48 or 96 hr after dosing. Amino acid concentrations were quantified by HPLC/EC following precolumn derivatization with o-phthalaldehyde-tert-butylthiol. TMT produced dose-dependent increases in aspartate, glutamine and glycine in the caudate nucleus (CN), frontal cortex (FC) and hippocampus (HIP) at 3.0 and 5.0 mg/kg. TMT at 3.0 mg/kg produced significant increases of aspartate in FC and HIP after 48 hr. Glutamine concentrations were significantly increased at 24 and 48 hr in HIP and at 48 hr in CN. Glycine and GABA concentrations were significantly increased at 48 and 96 hr respectively in the HIP. Glutamine was increased in plasma at 4 and 12 hr and in liver at 24 hr. Hyperammonemia occurred in plasma after 8 hr and continued through 24 hr and was accompanied by an increase in serum urea nitrogen.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Pharmacology & toxicology AU - Lipe, G W AU - Ali, S F AU - Newport, G D AU - Scallet, A C AU - Slikker, W AD - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 450 EP - 455 VL - 68 IS - 6 SN - 0901-9928, 0901-9928 KW - Amino Acids KW - 0 KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Ammonia -- blood KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - Blood Urea Nitrogen KW - Male KW - Amino Acids -- isolation & purification KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Trimethyltin Compounds -- administration & dosage KW - Brain -- metabolism KW - Amino Acids -- metabolism KW - Trimethyltin Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72090697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+toxicology&rft.atitle=Effect+of+trimethyltin+on+amino+acid+concentrations+in+different+regions+of+the+mouse+brain.&rft.au=Lipe%2C+G+W%3BAli%2C+S+F%3BNewport%2C+G+D%3BScallet%2C+A+C%3BSlikker%2C+W&rft.aulast=Lipe&rft.aufirst=G&rft.date=1991-06-01&rft.volume=68&rft.issue=6&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+toxicology&rft.issn=09019928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-17 N1 - Date created - 1991-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Marked increase in the teratogenicity of the combined administration of the industrial solvent 2-methoxyethanol and radiofrequency radiation in rats. AN - 72066065; 1882353 AB - Limited published animal research reports synergistic teratogenic effects following combined hyperthermia (induced by elevated ambient temperature) and administration of chemical teratogens. Radiofrequency (RF) radiation is widely used in occupational environments. Since RF radiation also elevates the body temperature of, and is teratogenic to, exposed animals, concurrent RF radiation and chemical agent administration may enhance teratogenicity. The present exploratory study, consisting of preliminary dose-finding studies and the primary study, was designed to investigate whether concurrent exposure of rats to RF radiation and the industrial solvent 2-methoxyethanol (2ME) can enhance the developmental toxicity of either agent acting alone. Preliminary dose-finding studies using small numbers of rats investigated the ability of various RF radiation conditions and doses of 2ME to produce external malformations (primarily of the paws) when administered on gestation day 13. Based on these preliminary studies, RF radiation exposure [sufficient to elevate rectal temperature to 42.0 degrees C (4 degrees C above normal for rats) for 30 min] and 2ME administration (150 mg/kg) were selected for the primary study. In the primary study, groups of 18 to 27 pregnant rats were administered RF radiation exposure and distilled water gavage, 2ME gavage and sham RF exposure, RF radiation exposure and 2ME gavage concurrently, or sham RF exposure and distilled water gavage. Pregnant rats were sacrificed on gestation day 20, and the offspring were examined for external malformations. Combined exposures enhanced the adverse effects produced by either experimental agent alone (no malformations were detected in the double sham group). Mean fetal malformations/litter increased from 14% after 2ME and sham RF (15/26 litters affected, with an average of 2 fetuses/litter malformed) and 30% after RF radiation and water gavage (10/18 litters affected, with an average of 4 fetuses/litter malformed), to 76% after the combined treatment (18/18 litters affected, with an average of 12 fetuses/litter malformed). In addition to a significant increase in the frequency of malformations, the severity of malformations also was enhanced by the combination treatment (on a relative severity ranking scale, the 2ME severity score was less than 1, the RF score was 3, and the combination score was 6). This study provided evidence of synergism between RF radiation and 2ME administration, but additional research will be required to characterize the extent of synergism between these two agents. Potential interactive effects between chemical and physical agents need to be investigated to determine the extent to which such interactions should impact occupational exposure standards. JF - Teratology AU - Nelson, B K AU - Conover, D L AU - Brightwell, W S AU - Shaw, P B AU - Werren, D AU - Edwards, R M AU - Lary, J M AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 621 EP - 634 VL - 43 IS - 6 SN - 0040-3709, 0040-3709 KW - Ethylene Glycols KW - 0 KW - methyl cellosolve KW - EK1L6XWI56 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Occupational Exposure KW - Maternal-Fetal Exchange KW - Animals KW - Dose-Response Relationship, Drug KW - Dose-Response Relationship, Radiation KW - Female KW - Pregnancy KW - Fetal Death KW - Ethylene Glycols -- toxicity KW - Infrared Rays -- adverse effects KW - Congenital Abnormalities -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72066065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Marked+increase+in+the+teratogenicity+of+the+combined+administration+of+the+industrial+solvent+2-methoxyethanol+and+radiofrequency+radiation+in+rats.&rft.au=Nelson%2C+B+K%3BConover%2C+D+L%3BBrightwell%2C+W+S%3BShaw%2C+P+B%3BWerren%2C+D%3BEdwards%2C+R+M%3BLary%2C+J+M&rft.aulast=Nelson&rft.aufirst=B&rft.date=1991-06-01&rft.volume=43&rft.issue=6&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-03 N1 - Date created - 1991-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro. AN - 72065193; 1882348 AB - The anticonvulsant drug valproic acid (VPA) is suspected to be a developmental toxicant in humans, inducing primarily neural tube defects. The mechanism for this effect is unknown, but it has been suggested that the drug may act via a deficiency of the vitamin folic acid. We examined this possibility by concurrent treatment of rat embryos in a whole embryo culture system with VPA and folinic acid (FA), a folic acid derivative. Groups of CD rat embryos were treated with various concentrations of VPA, various concentrations of FA, or a combination of a teratogenic dose of VPA plus various levels of FA. At the end of the 44 hour culture period, each embryo was evaluated for viability (presence of a heartbeat), yolk sac circulation, presence of any malformations, morphological score, crown-rump and head lengths, as well as DNA and protein contents. The anticonvulsant did not decrease viability but did decrease yolk sac circulation and all growth and developmental endpoints in a dose-responsive manner. There was also a dose-related increase in the incidence of open neural tubes. The addition of FA alone had no significant effect on growth and development. When various concentrations of FA were added simultaneously with a teratogenic dose of VPA, there was no decrease in the incidence of open neural tubes. Growth and developmental endpoints were altered in a somewhat random fashion but were never increased to the control level. The lack of attenuation by FA was not due to instability of the compound in the culture system, nor was there a difference in the amount of FA present in the exocoelomic fluid of VPA-treated and control embryos.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Teratology AU - Hansen, D K AU - Grafton, T F AD - Division of Reproductive and Developmental Toxicology, Food and Drug Administration, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 575 EP - 582 VL - 43 IS - 6 SN - 0040-3709, 0040-3709 KW - Valproic Acid KW - 614OI1Z5WI KW - Leucovorin KW - Q573I9DVLP KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Fetal Death -- chemically induced KW - Female KW - Pregnancy KW - Leucovorin -- toxicity KW - Valproic Acid -- toxicity KW - Neural Tube Defects -- chemically induced KW - Leucovorin -- pharmacology KW - Embryo, Mammalian -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72065193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Lack+of+attenuation+of+valproic+acid-induced+effects+by+folinic+acid+in+rat+embryos+in+vitro.&rft.au=Hansen%2C+D+K%3BGrafton%2C+T+F&rft.aulast=Hansen&rft.aufirst=D&rft.date=1991-06-01&rft.volume=43&rft.issue=6&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-03 N1 - Date created - 1991-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mortality among workers exposed to ethylene oxide. AN - 80522864; 2020295 AB - Ethylene oxide is a sterilant gas that causes leukemia and other cancers in animals. Studies in Sweden have shown an excess of leukemia and stomach cancer in humans exposed to ethylene oxide, but other studies have generally failed to confirm these findings. We conducted a study of mortality in 18,254 U.S. workers exposed to ethylene oxide at 14 plants producing sterilized medical supplies and spices. The subjects averaged 4.9 years of exposure to the gas and 16 years of follow-up. The exposure levels in recent years averaged 4.3 ppm (eight-hour time-weighted adjusted exposure) for sterilizer operators and 2.0 ppm for other workers. The levels in earlier years are likely to have been several times higher. Mortality in this cohort was compared with that in the general U.S. population. Overall there was no significant increase in mortality from any cause in the study cohort. The standardized mortality ratios (SMRs) were 0.97 for leukemia (95 percent confidence interval, 0.52 to 1.67; 13 deaths observed), 1.06 for all hematopoietic cancers (95 percent confidence interval, 0.75 to 1.47; 36 deaths), and 0.94 for stomach cancer (95 percent confidence interval, 0.45 to 1.70; 11 deaths). Analyses according to job category and according to the duration of exposure showed no excess in cancers, as compared with the rate in the general population, but there was a significant trend toward increased mortality with increasing lengths of time since the first exposure for all hematopoietic cancers. The rate of death from hematopoietic cancer (especially non-Hodgkin's lymphoma) was significantly increased among men (SMR, 1.55; 27 deaths). Mortality from leukemia in recent years (1985 through 1987) was significantly increased among men (SMR, 3.45; 5 deaths). For the entire cohort, there was no increase in mortality from hematopoietic cancer. There was a slight but significant increase among men, however. Among men and women combined, there was a trend toward an increased risk of death from hematopoietic cancer with increasing lengths of time since the first exposure to ethylene oxide. JF - The New England journal of medicine AU - Steenland, K AU - Stayner, L AU - Greife, A AU - Halperin, W AU - Hayes, R AU - Hornung, R AU - Nowlin, S AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/05/16/ PY - 1991 DA - 1991 May 16 SP - 1402 EP - 1407 VL - 324 IS - 20 SN - 0028-4793, 0028-4793 KW - Ethylene Oxide KW - JJH7GNN18P KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Exposure KW - Lymphoma -- mortality KW - Leukemia -- mortality KW - Stomach Neoplasms -- mortality KW - Neoplasms -- mortality KW - Humans KW - Cohort Studies KW - United States -- epidemiology KW - Time Factors KW - Male KW - Female KW - Occupational Diseases -- mortality KW - Mortality KW - Ethylene Oxide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80522864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Mortality+among+workers+exposed+to+ethylene+oxide.&rft.au=Steenland%2C+K%3BStayner%2C+L%3BGreife%2C+A%3BHalperin%2C+W%3BHayes%2C+R%3BHornung%2C+R%3BNowlin%2C+S&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-05-16&rft.volume=324&rft.issue=20&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-30 N1 - Date created - 1991-05-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Oct 24;325(17):1254 [1922217] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice. AN - 80552471; 1674234 AB - Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice. To assess differences in PB induction of hepatic drug metabolizing enzymes, yellow Avy/A (C3H x VY) F1 hybrid male mice were fed 0.05% sodium PB in NIH-31 diet for 7 months. Livers from the heaviest and lightest mice in the untreated and PB groups were assayed. Total cytochrome P450 content, cytochrome P450IA-selective 7-ethoxyresorufin-O-deethylase and P450IIIA-selective testosterone-6 beta-hydroxylase activities were preferentially induced in the light mice. In contrast, P450IIB-selective 7-pentoxyresorufin-O-dealkylase activity was increased only 3-fold by PB in the light mice but 6-fold in the heavy mice. Testosterone UDP-glucuronyltransferase and gamma-glutamyltranspeptidase activities were induced in the light mice but not in the heavy mice. Glutathione-S-transferase N1:1-dependent activity was induced preferentially in the heavy mice. Significant differences also occurred in constitutive expression of P450IIIA-selective testosterone-6 beta-hydroxylase, P450IA-selective 7-ethoxyresorufin-O-deethylase and testosterone UDP-glucuronyltransferase activities between the untreated weight groups. Thus, expression of constitutive and PB-inducible forms of hepatic drug metabolizing enzymes differs between heavy and light Avy/A (C3H x VY) F1 hybrid subpopulations. This suggests that differential susceptibility to PB promotion of hepatocellular adenomas among genetically identical mice is accompanied by differences in the regulation of gene expression. JF - Carcinogenesis AU - Wolff, G L AU - Leakey, J E AU - Bazare, J J AU - Harmon, J R AU - Webb, P J AU - Law, M G AD - Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 911 EP - 915 VL - 12 IS - 5 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Isoenzymes KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Oxidoreductases KW - Steroid Hydroxylases KW - EC 1.14.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP2B1 KW - testosterone 7-alpha-hydroxylase, hamster KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - gamma-Glutamyltransferase -- metabolism KW - Glutathione Transferase -- metabolism KW - Steroid Hydroxylases -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Glucuronosyltransferase -- metabolism KW - Mice KW - Organ Size KW - Isoenzymes -- metabolism KW - Body Weight KW - Blotting, Western KW - Mixed Function Oxygenases -- metabolism KW - Oxidoreductases -- metabolism KW - Adenoma -- enzymology KW - Male KW - Microsomes, Liver -- enzymology KW - Liver Neoplasms -- chemically induced KW - Phenobarbital -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80552471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Susceptibility+to+phenobarbital+promotion+of+hepatotumorigenesis%3A+correlation+with+differential+expression+and+induction+of+hepatic+drug+metabolizing+enzymes+in+heavy+and+light+male+%28C3H+x+VY%29+F1+hybrid+mice.&rft.au=Wolff%2C+G+L%3BLeakey%2C+J+E%3BBazare%2C+J+J%3BHarmon%2C+J+R%3BWebb%2C+P+J%3BLaw%2C+M+G&rft.aulast=Wolff&rft.aufirst=G&rft.date=1991-05-01&rft.volume=12&rft.issue=5&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-19 N1 - Date created - 1991-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse reaction reporting of interaction between warfarin and fluoroquinolones. AN - 80545454; 1842668 AB - Reports to the Food and Drug Administration's Adverse Drug Reaction Reporting System of prolonged prothrombin time due to a suspected interaction between warfarin sodium and a fluoroquinolone were reviewed. Five reports of patients who experienced this adverse reaction 2 to 16 days after the addition of a fluoroquinolone to their treatment regimen are described. Possible mechanisms of action that are discussed include inhibition of warfarin metabolism by the anti-infective agent and displacement of warfarin's binding to protein. Physicians need to be aware of this interaction and closely monitor prothrombin time in patients concurrently receiving warfarin and a fluoroquinolone. JF - Archives of internal medicine AU - Jolson, H M AU - Tanner, L A AU - Green, L AU - Grasela, T H AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 1003 EP - 1004 VL - 151 IS - 5 SN - 0003-9926, 0003-9926 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Warfarin KW - 5Q7ZVV76EI KW - Norfloxacin KW - N0F8P22L1P KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Drug Interactions KW - United States Food and Drug Administration KW - Aged, 80 and over KW - Humans KW - Adult KW - Product Surveillance, Postmarketing KW - Aged KW - Middle Aged KW - Male KW - Female KW - Warfarin -- adverse effects KW - Norfloxacin -- adverse effects KW - Ciprofloxacin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80545454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Adverse+reaction+reporting+of+interaction+between+warfarin+and+fluoroquinolones.&rft.au=Jolson%2C+H+M%3BTanner%2C+L+A%3BGreen%2C+L%3BGrasela%2C+T+H&rft.aulast=Jolson&rft.aufirst=H&rft.date=1991-05-01&rft.volume=151&rft.issue=5&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1992 Jul;152(7):1533-4 [1627042] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Urolithiasis in Tennessee: an occupational window into a regional problem. AN - 80511095; 2014858 AB - Urinary tract stones (stones) are believed to be unusually common in the southeastern United States but neither the incidence of nor the risk factors for stones are known. In three well-defined occupational populations in eastern Tennessee, we assessed the prevalence, incidence, and cumulative incidence of stones and measured biochemical risk factors for lithogenesis. The age-adjusted prevalence of stones was 18.5 percent in Tennessee compared to 7.7 percent among White males in US NHANES (prevalence ratio 2.4, 95% CI 1.7, 3.3). The cumulative incidence (risk) was 27.8 percent by age 65, higher than in any other reported population. Risk factors were age, a family history, and urinary saturation with calcium-oxalate (COAX). Persons with a positive family history and the highest measured CAOX index had a predicted lifetime risk of 88.8 percent. Biochemical factors affecting lithogenesis were hypercalciuria, hyperoxaluria, and low urine volume. Future research should characterize the geographic boundaries of a southeastern "stone-belt" and explore genetic and dietary hypotheses that might explain it. JF - American journal of public health AU - Thun, M J AU - Schober, S AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 587 EP - 591 VL - 81 IS - 5 SN - 0090-0036, 0090-0036 KW - Calcium Oxalate KW - 2612HC57YE KW - Uranium KW - 4OC371KSTK KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Aged KW - Dairying KW - Uranium -- adverse effects KW - Calcium Oxalate -- urine KW - Logistic Models KW - Risk Factors KW - Tennessee -- epidemiology KW - Adult KW - Incidence KW - Middle Aged KW - Occupations KW - Urine -- chemistry KW - Male KW - Metallurgy KW - Prevalence KW - Kidney Calculi -- chemically induced KW - Kidney Calculi -- epidemiology KW - Kidney Calculi -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80511095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Urolithiasis+in+Tennessee%3A+an+occupational+window+into+a+regional+problem.&rft.au=Thun%2C+M+J%3BSchober%2C+S&rft.aulast=Thun&rft.aufirst=M&rft.date=1991-05-01&rft.volume=81&rft.issue=5&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-16 N1 - Date created - 1991-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Urol. 1979 Sep;122(3):288-91 [469997] Kidney Int. 1979 Nov;16(5):624-31 [548606] Am J Epidemiol. 1982 Feb;115(2):255-65 [7058784] J Urol. 1982 Aug;128(2):422-5 [7109123] J Chronic Dis. 1985;38(11):907-14 [4055979] J Urol. 1985 Nov;134(5):867-70 [4057368] Invest Urol. 1978 May;15(6):438-41 [649290] Aviat Space Environ Med. 1989 Feb;60(2):157-61 [2930428] N Engl J Med. 1989 May 11;320(19):1238-43 [2651928] Am J Med. 1968 Nov;45(5):715-35 [4879833] N Engl J Med. 1974 Dec 19;291(25):1344-50 [4610395] Lancet. 1975 May 10;1(7915):1063-5 [48731] Br J Urol. 1987 Jul;60(1):10-3 [3620841] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data. AN - 72447102; 1935845 AB - The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study. The model successfully predicts liver tumor incidence for time points beyond termination of dosing with 2-acetylaminofluorene, but it is unsuccessful for bladder tumor incidence. A discontinued dosing version of the Weibull model is proposed and is shown to predict successfully both liver and bladder tumor incidences for time points after termination of dosing. JF - Environmental health perspectives AU - Kodell, R L AU - Felton, R P AD - National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 155 EP - 166 VL - 92 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Animals KW - 2-Acetylaminofluorene -- administration & dosage KW - 2-Acetylaminofluorene -- toxicity KW - Cocarcinogenesis KW - Liver Neoplasms -- chemically induced KW - Mice KW - Female KW - Urinary Bladder Neoplasms -- chemically induced KW - Proportional Hazards Models KW - Carcinogens -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72447102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Two-stage+and+Weibull+models+for+carcinogenesis+applied+to+the+ED01+discontinued+dosing+data.&rft.au=Kodell%2C+R+L%3BFelton%2C+R+P&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-05-01&rft.volume=92&rft.issue=&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-09 N1 - Date created - 1991-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Environ Pathol Toxicol. 1980;3(3 Spec No):17-34 [7365379] Math Biosci. 1989 May;94(1):1-29 [2520163] J Natl Cancer Inst. 1980 Apr;64(4):977-89 [6929006] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Food Cosmet Toxicol. 1981 Jun;19(3):367-71 [7262748] Biometrics. 1982 Mar;38(1):43-58 [7082762] Biometrics. 1982 Dec;38(4):921-32 [7168795] Fundam Appl Toxicol. 1983 Sep-Oct;3(5):458-69 [6642103] Fundam Appl Toxicol. 1983 Sep-Oct;3(5):470-7 [6642104] Carcinogenesis. 1984 Apr;5(4):437-45 [6705147] Biometrics. 1984 Mar;40(1):41-50 [6733233] Fundam Appl Toxicol. 1986 Aug;7(2):183-90 [3758535] Risk Anal. 1987 Mar;7(1):109-19 [3615992] Risk Anal. 1988 Jun;8(2):223-30 [3413310] J Natl Cancer Inst. 1989 Feb 15;81(4):267-77 [2913324] Environ Health Perspect. 1989 May;81:169-88 [2667978] Toxicol Appl Pharmacol. 1990 Jun 1;104(1):79-93 [2360210] J Environ Pathol Toxicol. 1980;3(3 Spec No):35-54 [7365385] N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Delivering essential health care services in rural areas: an analysis of alternative models T2 - AHCPR pubn. no. 91-0017 AN - 59563058; 1991-1210235 AB - Analyzes programs developed by selected states and communities to convert closed or failing rural hospitals into facilities providing a limited range of services. Programs addressing low volumes of inpatient services, shortages of health care personnel, and financial distress. JF - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, May 1991. 50 pp. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 50 PB - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - United States -- Medical sector KW - Medical service, Rural -- United States KW - Hospitals -- Finance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59563058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Delivering+essential+health+care+services+in+rural+areas%3A+an+analysis+of+alternative+models&rft.title=Delivering+essential+health+care+services+in+rural+areas%3A+an+analysis+of+alternative+models&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 pa N1 - Document feature - bibl(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - From the Assistant Secretary for Health, US Public Health Service. AN - 80507948; 2013918 JF - JAMA AU - Mason, J O AD - DHHS Assistant Secretary for Health, Public Health Service. Y1 - 1991/04/24/ PY - 1991 DA - 1991 Apr 24 SP - 2049 VL - 265 IS - 16 SN - 0098-7484, 0098-7484 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Health Promotion -- organization & administration KW - Child KW - Lead Poisoning -- prevention & control KW - United States Public Health Service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80507948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Assistant+Secretary+for+Health%2C+US+Public+Health+Service.&rft.au=Mason%2C+J+O&rft.aulast=Mason&rft.aufirst=J&rft.date=1991-04-24&rft.volume=265&rft.issue=16&rft.spage=2049&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-10 N1 - Date created - 1991-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 80484698; 1848642 JF - JAMA AU - Nightingale, S L AD - Office of Health Affairs, FDA, Rockville, MD 20857. Y1 - 1991/04/10/ PY - 1991 DA - 1991 Apr 10 SP - 1802 VL - 265 IS - 14 SN - 0098-7484, 0098-7484 KW - Biological Products KW - 0 KW - Drugs, Investigational KW - Hydroxybutyrates KW - Pharmaceutical Preparations KW - Succimer KW - DX1U2629QE KW - 2-hydroxybutyric acid KW - O0ADR0I4H5 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Child KW - Lead Poisoning -- drug therapy KW - Hydroxybutyrates -- adverse effects KW - Succimer -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80484698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1991-04-10&rft.volume=265&rft.issue=14&rft.spage=1802&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline. AN - 80481125; 2005633 AB - A retrospective cohort study of the incidence of bladder cancer was conducted in response to a union request for an evaluation of a possible excess number of cases of bladder cancer at a chemical plant in western New York State. Workers at the plant were exposed to two potential bladder carcinogens--ortho-toluidine (o-toluidine) and aniline. Incidence rates of bladder cancer among workers at the plant were compared with those of the population of New York State (excluding New York City). Among all 1749 workers at the plant, 13 cases of bladder cancer were observed versus 3.61 expected [standardized incidence ratio (SIR) = 3.60; 90% confidence interval (CI) = 2.13-5.73]. Among the 708 workers who worked in areas in which o-toluidine and aniline were used, 7 cases were observed versus 1.08 expected (SIR = 6.48; 90% CI = 3.04-12.2). Among the 288 maintenance, shipping, and janitorial workers thought to have been possibly exposed, 4 cases were observed versus 1.09 expected (SIR = 3.66; 90% CI = 1.25-8.37). Among the remaining 753 workers who were probably not exposed, 2 bladder cancers were observed versus 1.43 expected (SIR = 1.39; 90% CI = 0.25-4.39). Increased risk of bladder cancer was strongly associated with increased duration of employment in the department where o-toluidine and aniline were used (P less than .001). Among workers with 10 or more years of employment in the department, the SIR was 27.2 (90% CI = 11.8-53.7). o-Toluidine is an animal carcinogen more potent than aniline and is known to produce bladder tumors in rats; hence, it is more likely that o-toluidine is responsible for the observed excess number of cases of bladder cancer, although aniline may have played a role. JF - Journal of the National Cancer Institute AU - Ward, E AU - Carpenter, A AU - Markowitz, S AU - Roberts, D AU - Halperin, W AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/04/03/ PY - 1991 DA - 1991 Apr 03 SP - 501 EP - 506 VL - 83 IS - 7 SN - 0027-8874, 0027-8874 KW - Aniline Compounds KW - 0 KW - Toluidines KW - 2-toluidine KW - B635MZ0ZLU KW - aniline KW - SIR7XX2F1K KW - Index Medicus KW - Occupational Exposure KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Retrospective Studies KW - Smoking -- adverse effects KW - Aged KW - Middle Aged KW - Male KW - Female KW - Urinary Bladder Neoplasms -- epidemiology KW - Aniline Compounds -- toxicity KW - Urinary Bladder Neoplasms -- chemically induced KW - Toluidines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80481125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Excess+number+of+bladder+cancers+in+workers+exposed+to+ortho-toluidine+and+aniline.&rft.au=Ward%2C+E%3BCarpenter%2C+A%3BMarkowitz%2C+S%3BRoberts%2C+D%3BHalperin%2C+W&rft.aulast=Ward&rft.aufirst=E&rft.date=1991-04-03&rft.volume=83&rft.issue=7&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-19 N1 - Date created - 1991-04-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 1994 Jan 5;86(1):59-62 [8271286] J Natl Cancer Inst. 1991 Nov 20;83(22):1686-7 [1749022] J Natl Cancer Inst. 1991 Oct 16;83(20):1507-8 [1920498] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Work posture, workstation design, and musculoskeletal discomfort in a VDT data entry task. AN - 80709668; 1860702 AB - Self-report data on musculoskeletal discomfort were collected from several hundred VDT users in two agencies of a state government. Aspects of worker posture and workstation design were objectively assessed for 40 of the VDT users. Multiple regression analyses were used to examine the relationship between these ergonomic variables and musculoskeletal discomfort. Effects of ergonomic factors on musculoskeletal discomfort were clearly evident in the analyses. Regression models explained up to 38% of the variance in discomfort at different body sites. Of special interest was that leg discomfort increased with low, soft seat pans, suggesting that postural constraint is more important than thigh compression as a risk factor for leg discomfort in VDT work. In addition, arm discomfort increased with increases in keyboard height above elbow level, supporting arguments for low placement of the keyboard. Finally, high levels of neck and shoulder girdle discomfort observed in the study population suggest the need for further attention to the control of cervicobrachial pain syndromes in VDT work. JF - Human factors AU - Sauter, S L AU - Schleifer, L M AU - Knutson, S J AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 151 EP - 167 VL - 33 IS - 2 SN - 0018-7208, 0018-7208 KW - Index Medicus KW - Space life sciences KW - Risk Factors KW - Humans KW - Brachial Plexus Neuritis -- physiopathology KW - Adult KW - Cumulative Trauma Disorders -- physiopathology KW - Male KW - Female KW - Pain -- physiopathology KW - Computer Terminals KW - Occupational Diseases -- physiopathology KW - Posture -- physiology KW - Muscles -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80709668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+factors&rft.atitle=Work+posture%2C+workstation+design%2C+and+musculoskeletal+discomfort+in+a+VDT+data+entry+task.&rft.au=Sauter%2C+S+L%3BSchleifer%2C+L+M%3BKnutson%2C+S+J&rft.aulast=Sauter&rft.aufirst=S&rft.date=1991-04-01&rft.volume=33&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Human+factors&rft.issn=00187208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-04 N1 - Date created - 1991-09-04 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse. AN - 80704101; 1855627 AB - An embryotoxic oral dose of bis(2-methoxyethyl) ether (DGDME), 3.73 mmol/kg body wt (500 mg/kg), administered on the 11th day of gestation to pregnant CD-1 mice was metabolized predominantly by O-demethylation to 2-(2-methoxyethoxy)ethanol with subsequent oxidation to (2-methoxyethoxy)acetic acid. Urinary excretion of this metabolite over 48 hr amounted to 63 +/- 2% of the dose. A smaller percentage of the administered dose was metabolized at the central ether linkage to produce 2-methoxyethanol, which was further metabolized by alcohol dehydrogenase to methoxyacetic acid. Urinary excretion of methoxyacetic acid, a potent developmental toxicant, amounted to 28 +/- 1% of the administered dose by 48 hr and was the second most prominent urinary metabolite. Unchanged DGDME and methoxyacetic acid were detected in the embryonic tissues from these animals, and embryos harvested after the initial 6-hr period showed detectable amounts of only methoxyacetic acid. The average amount of methoxyacetic acid per embryo was calculated to be 1.5 +/- 1.0 mumol (5.9 mmol/kg body wt) at the 6-hr termination time. This finding suggests that the reported teratogenic effects of DGDME are due to methoxyacetic acid formed, either in the fetus or by hepatic metabolism in the dam with subsequent distribution to the embryonic tissue. These results suggest that such developmental toxicity may occur with structurally similar aprotic ethylene glycol ethers in which metabolic O-dearylation would yield 2-methoxy-ethanol. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Daniel, F B AU - Cheever, K L AU - Begley, K B AU - Richards, D E AU - Weigel, W W AU - Eisenmann, C J AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 567 EP - 575 VL - 16 IS - 3 SN - 0272-0590, 0272-0590 KW - Ethylene Glycols KW - 0 KW - Methyl Ethers KW - Teratogens KW - diglyme KW - M4BH3X0MVZ KW - Index Medicus KW - Mice, Inbred Strains KW - Mass Spectrometry KW - Animals KW - Mice KW - Female KW - Chromatography, High Pressure Liquid KW - Pregnancy KW - Teratogens -- metabolism KW - Methyl Ethers -- metabolism KW - Fetus -- drug effects KW - Ethylene Glycols -- toxicity KW - Ethylene Glycols -- metabolism KW - Methyl Ethers -- toxicity KW - Fetus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80704101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Bis%282-methoxyethyl%29+ether%3A+metabolism+and+embryonic+disposition+of+a+developmental+toxicant+in+the+pregnant+CD-1+mouse.&rft.au=Daniel%2C+F+B%3BCheever%2C+K+L%3BBegley%2C+K+B%3BRichards%2C+D+E%3BWeigel%2C+W+W%3BEisenmann%2C+C+J&rft.aulast=Daniel&rft.aufirst=F&rft.date=1991-04-01&rft.volume=16&rft.issue=3&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-29 N1 - Date created - 1991-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of epidemiology data to assess the cancer risk of 2,3,7,8-tetrachlorodibenzo-p-dioxin. AN - 80691332; 1852927 AB - Most countries have assessed the human cancer risk of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by extrapolating from animal data. The 1600-fold variation for acceptable intakes estimated by the Americans, Canadians, and Europeans, however, indicates a large scientific uncertainty about TCDD toxicity. Regulators are attempting to use human epidemiology data to eliminate some of the limitations inherent in using animal data to quantitatively assess cancer risk in humans, particularly now that techniques for measuring TCDD levels in adipose tissue and serum are available. This paper presents an overview of the major epidemiologic studies that associate cancer with TCDD exposure. The actual exposures experienced by the study populations are emphasized. The TCDD serum levels of the Seveso, Italy, residents and of the NIOSH Dioxin Registry participants indicate that these populations hold the best promise for future assessment of the human carcinogenic risk of dioxin. Based on the animal data, however, the calculated risk from these exposures is still moderate compared with high background cancer incidence present in most industrialized countries. JF - Regulatory toxicology and pharmacology : RTP AU - Tollefson, L AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 150 EP - 169 VL - 13 IS - 2 SN - 0273-2300, 0273-2300 KW - Polychlorinated Dibenzodioxins KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Neoplasms -- chemically induced KW - Polychlorinated Dibenzodioxins -- toxicity KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80691332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Use+of+epidemiology+data+to+assess+the+cancer+risk+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Tollefson%2C+L&rft.aulast=Tollefson&rft.aufirst=L&rft.date=1991-04-01&rft.volume=13&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-20 N1 - Date created - 1991-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An overview of process hazard evaluation techniques. AN - 80671949; 2069123 AB - Since the 1985 release of methyl isocyanate in Bhopal, India, which killed thousands, the chemical industry has begun to use process hazard analysis techniques more widely to protect the public from catastrophic chemical releases. These techniques can provide a systematic method for evaluating a system design to ensure that it operates as intended, help identify process areas that may result in the release of a hazardous chemical, and help suggest modifications to improve process safety. Eight different techniques are discussed, with some simple examples of how they might be applied. These techniques include checklists, "what if" analysis, safety audits and reviews, preliminary hazard analysis (PHA), failure modes and effect analysis (FMEA), fault tree analysis (FTA), event tree analysis (ETA), and hazard and operability studies (HAZOP). The techniques vary in sophistication and scope, and no single one will always be the best. These techniques can also provide the industrial hygienist with the tools needed to protect both workers and the community from both major and small-scale chemical releases. A typical industrial hygiene evaluation of a facility would normally include air sampling. If the air sampling does detect a specific hazardous substance, the source will probably be a routine or continuous emission. However, air sampling will not be able to identify or predict the location of a nonroutine emission reliably. By incorporating these techniques with typical evaluations, however, industrial hygienists can proactively help reduce the hazards to the workers they serve. JF - American Industrial Hygiene Association journal AU - Gressel, M G AU - Gideon, J A AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 158 EP - 163 VL - 52 IS - 4 SN - 0002-8894, 0002-8894 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Evaluation Studies as Topic KW - Occupational Health KW - Decision Trees KW - Hazardous Substances -- analysis KW - Decision Support Techniques KW - Disaster Planning KW - Accident Prevention KW - Chemical Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80671949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=An+overview+of+process+hazard+evaluation+techniques.&rft.au=Gressel%2C+M+G%3BGideon%2C+J+A&rft.aulast=Gressel&rft.aufirst=M&rft.date=1991-04-01&rft.volume=52&rft.issue=4&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-13 N1 - Date created - 1991-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interleukin-2 toxicity. AN - 80666609; 2066765 AB - Because of the ability of interleukin-2 (IL-2) to support the proliferation and activation of numerous types of immunocompetent cells and to support the survival of adoptively transferred lymphocytes, there has been considerable interest in its use in the immunotherapy of malignancies. While studies to date have indicated that IL-2 has activity against some malignancies, considerable toxicity has also been observed. Careful prescreening and selection of patients and appropriate management of toxicity can minimize adverse outcomes. Studies of IL-2 effects have provided intriguing evidence of interactions of the immune/cytokine system with the neuroendocrine, cardiovascular, and other systems. Studies in animal models have demonstrated the central role of an intact immune system in mediating many toxicities of IL-2. Several adverse effects of IL-2 appear to be mediated by other cytokines whose production is induced by IL-2. Studies into the pathogenesis and manifestations of IL-2 toxicity have offered the hope of developing less toxic approaches to IL-2 therapy. Several lessons from the IL-2 experience are likely to be applicable in the clinical development of other cytokines. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Siegel, J P AU - Puri, R K AD - Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 694 EP - 704 VL - 9 IS - 4 SN - 0732-183X, 0732-183X KW - Interleukin-2 KW - 0 KW - Index Medicus KW - Syndrome KW - Humans KW - Capillary Permeability -- drug effects KW - Interleukin-2 -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80666609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Interleukin-2+toxicity.&rft.au=Siegel%2C+J+P%3BPuri%2C+R+K&rft.aulast=Siegel&rft.aufirst=J&rft.date=1991-04-01&rft.volume=9&rft.issue=4&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 ER - TY - JOUR T1 - An epidemic of dermatitis at a large construction site. AN - 80573613; 1828081 AB - During 6 months in 1986, an epidemic of dermatitis occurred among more than 5600 workers at a single large construction site in the United States. To identify its cause, we used the monthly nurses' log of visits to the medical facility to characterize the outbreak by person, place, and time. Follow-up studies included a survey of carpenters and skin testing of laboratory animals. Workers were more than twice as likely to visit the medical facility for a skin-related complaint in 1986 compared with 1985 (relative rate [RR] = 2.6, 95% confidence interval [CI] 2.2-3.2). Carpenters experienced the greatest increased risk (RR = 9.7, 95% CI 5.5-17.3). We found a strong association between dermatitis and handling of fire-retardant lumber and plywood. Carpenters working only with fire-retardant lumber had a rate of dermatitis 4 times that of carpenters who worked exclusively with untreated wood (RR = 3.6, 95% CI 1.5-8.6). Carpenters who occasionally worked with fire-retardant lumber and plywood were at moderate risk (RR = 2.18, 95% CI 0.7-6.7). Although laboratory tests showed that phosphate compounds could be leached with water from the fire-retardant wood, an extract of these phosphates did not irritate the skin of laboratory animals. We concluded the epidemic was a result of handling fire-retardant lumber but could not identify the specific chemical agent. In view of the observed association, construction workers should be advised to handle this material with caution, especially in high temperature and humidity. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Sinks, T AU - O'Malley, M AU - Hartle, R AU - Hales, T R AU - Ruhe, R AD - DSHEFS, NIOSH, Cincinnati, OH 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 462 EP - 467 VL - 33 IS - 4 SN - 0096-1736, 0096-1736 KW - Flame Retardants KW - 0 KW - Index Medicus KW - Cross-Sectional Studies KW - Animals KW - Humans KW - Chi-Square Distribution KW - Surveys and Questionnaires KW - Confidence Intervals KW - Rabbits KW - Follow-Up Studies KW - United States -- epidemiology KW - Male KW - Female KW - Construction Materials -- adverse effects KW - Flame Retardants -- adverse effects KW - Wood KW - Flame Retardants -- toxicity KW - Dermatitis, Occupational -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80573613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=An+epidemic+of+dermatitis+at+a+large+construction+site.&rft.au=Sinks%2C+T%3BO%27Malley%2C+M%3BHartle%2C+R%3BHales%2C+T+R%3BRuhe%2C+R&rft.aulast=Sinks&rft.aufirst=T&rft.date=1991-04-01&rft.volume=33&rft.issue=4&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-03 N1 - Date created - 1991-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interactions of MK-801 with glutamate-, glutamine- and methamphetamine-evoked release of [3H]dopamine from striatal slices. AN - 80525052; 1673475 AB - The interactions of MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine], glutamate and glutamine with methamphetamine (METH)-evoked release of [3H]dopamine were assessed in vitro to determine whether MK-801 inhibition of METH neurotoxicity might be mediated presynaptically, and to evaluate the effects of glutamatergic stimulation on METH-evoked dopamine release. MK-801 inhibition of glutamate- or METH-evoked dopamine release might reduce synaptic dopamine levels during METH exposure and decrease the formation of 6-hydroxydopamine or other related neurotoxins. Without Mg++ present, 40 microM and 1 mM glutamate evoked a N-methyl-D-aspartate receptor-mediated [3H]dopamine and [3H]metabolite (tritium) release of 3 to 6 and 12 to 16% of total tritium stores, respectively, from striatal slices. With 1.50 mM Mg++ present, 10 mM glutamate alone or in combination with the dopamine uptake blocker nomifensine released only 2.1 or 4.2%, respectively, of total tritium stores, and release was only partially dependent on N-methyl-D-aspartate-type glutamate receptors. With or without 1.50 mM Mg++ present, 0.5 or 5 microM METH evoked a substantial release of tritium (5-8 or 12-21% of total stores, respectively). METH-evoked dopamine release was not affected by 5 microM MK-801 but METH-evoked release was additive with glutamate-evoked release. Without Mg++ present, 1 mM glutamine increased glutamate release and induced the release of [3H]dopamine and metabolites. Both 0.5 and 5 microM METH also increased tritium release with 1 mM glutamine present. When striatal slices were exposed to 5 microM METH this glutamine-evoked release of glutamate was increased more than 50%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Bowyer, J F AU - Scallet, A C AU - Holson, R R AU - Lipe, G W AU - Slikker, W AU - Ali, S F AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 262 EP - 270 VL - 257 IS - 1 SN - 0022-3565, 0022-3565 KW - Glutamates KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Glutamine KW - 0RH81L854J KW - Tritium KW - 10028-17-8 KW - Nomifensine KW - 1LGS5JRP31 KW - Glutamic Acid KW - 3KX376GY7L KW - Methamphetamine KW - 44RAL3456C KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Magnesium KW - I38ZP9992A KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - In Vitro Techniques KW - Magnesium -- pharmacology KW - Nomifensine -- pharmacology KW - Male KW - Dopamine -- secretion KW - Corpus Striatum -- secretion KW - Glutamine -- pharmacology KW - Glutamates -- pharmacology KW - Methamphetamine -- toxicity KW - Dizocilpine Maleate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80525052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Interactions+of+MK-801+with+glutamate-%2C+glutamine-+and+methamphetamine-evoked+release+of+%5B3H%5Ddopamine+from+striatal+slices.&rft.au=Bowyer%2C+J+F%3BScallet%2C+A+C%3BHolson%2C+R+R%3BLipe%2C+G+W%3BSlikker%2C+W%3BAli%2C+S+F&rft.aulast=Bowyer&rft.aufirst=J&rft.date=1991-04-01&rft.volume=257&rft.issue=1&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-24 N1 - Date created - 1991-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Formation of C8-modified deoxyguanosine and C8-modified deoxyadenosine as major DNA adducts from 2-nitropyrene metabolism mediated by rat and mouse liver microsomes and cytosols. AN - 80499906; 2013125 AB - 2-Nitropyrene, the geometric isomer of the most studied nitropolycyclic aromatic hydrocarbon (nitro-PAH), 1-nitropyrene, is an environmental contaminant detected in ambient air and a potent direct-acting mutagen. Its metabolic activation leading to the formation of DNA adducts was studied. The activated metabolite, N-hydroxy-2-aminopyrene, was prepared and reacted with calf thymus DNA. Upon enzymatic hydrolysis of the DNA, the resulting nucleosides were separated by HPLC, and the adducts were characterized by mass and proton NMR spectral analysis. Both N-(deoxyguanosin-8-yl)-2-aminopyrene and N-(deoxyadenosin-8-yl)-2-aminopyrene, in a 5:2 ratio, were identified. These adducts were then utilized as standards to identify the DNA adducts formed from reaction of [3H]2-nitropyrene with DNA mediated by liver microsomes and cytosols of mouse and rat. In all cases, both adducts were formed. The quantities of the two adducts formed in each system were: mouse liver microsomes (11.3 pmol [3H]2-nitropyrene/mg DNA), rat liver microsomes (23), mouse liver cytosol (11.4) and rat liver cytosol (5.1). Thus, these adducts were formed in highest yield from rat liver microsomes and the lowest from rat liver cytosol. The deoxyguanosine/deoxyadenosine adduct ratio was higher from rat and mouse liver microsomes (7.8:9.2) than from rat and mouse liver cytosols (2.5:3.1). Our results represent the first direct demonstration of a C8-deoxyadenosine adduct being formed as a major product from the reaction of a nitro-PAH metabolite with DNA. JF - Carcinogenesis AU - Fu, P P AU - Miller, D W AU - Von Tungeln, L S AU - Bryant, M S AU - Lay, J O AU - Huang, K AU - Jones, L AU - Evans, F E AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 609 EP - 616 VL - 12 IS - 4 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Deoxyadenosines KW - Pyrenes KW - Tritium KW - 10028-17-8 KW - N-(deoxyguanosin-8-yl)-2-aminopyrene KW - 134249-04-0 KW - N-(deoxyadenosin-8-yl)-2-aminopyrene KW - 134249-05-1 KW - 2-nitropyrene KW - 789-07-1 KW - N-hydroxy-2-aminopyrene KW - 85964-28-9 KW - DNA KW - 9007-49-2 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Liver -- ultrastructure KW - Mice, Inbred Strains KW - Animals KW - Carcinogens -- metabolism KW - Liver -- drug effects KW - Thymus Gland -- metabolism KW - Liver -- metabolism KW - Mice KW - Male KW - Pyrenes -- toxicity KW - Cytosol -- metabolism KW - Deoxyguanosine -- metabolism KW - Microsomes, Liver -- metabolism KW - DNA -- metabolism KW - Pyrenes -- metabolism KW - Deoxyadenosines -- metabolism KW - Pyrenes -- chemical synthesis KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80499906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Formation+of+C8-modified+deoxyguanosine+and+C8-modified+deoxyadenosine+as+major+DNA+adducts+from+2-nitropyrene+metabolism+mediated+by+rat+and+mouse+liver+microsomes+and+cytosols.&rft.au=Fu%2C+P+P%3BMiller%2C+D+W%3BVon+Tungeln%2C+L+S%3BBryant%2C+M+S%3BLay%2C+J+O%3BHuang%2C+K%3BJones%2C+L%3BEvans%2C+F+E&rft.aulast=Fu&rft.aufirst=P&rft.date=1991-04-01&rft.volume=12&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-14 N1 - Date created - 1991-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Second cancers following non-Hodgkin's lymphoma. AN - 80478753; 2004317 AB - The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed/expected [O/E] = 1.18; O = 1231). The O/E ratio increased significantly with time to reach 1.77 in 10-year survivors. Significant excesses were noted for acute nonlymphocytic leukemia (O/E = 2.88), cancers of the bladder (O/E = 1.30), kidney (O/E = 1.47), and lung (O/E = 1.57), malignant melanoma (O/E = 2.44), and Hodgkin's disease (O/E = 4.16). Chemotherapy appeared related to subsequent acute nonlymphocytic leukemia (ANLL) and bladder cancer. Radiation therapy was associated with ANLL and possibly cancers of the lung, bladder, and bone. Malignant melanoma was not clearly related to initial NHL treatment. JF - Cancer AU - Travis, L B AU - Curtis, R E AU - Boice, J D AU - Hankey, B F AU - Fraumeni, J F AD - Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Y1 - 1991/04/01/ PY - 1991 DA - 1991 Apr 01 SP - 2002 EP - 2009 VL - 67 IS - 7 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Staging KW - Neoplasms, Radiation-Induced -- pathology KW - Combined Modality Therapy KW - Risk Factors KW - Neoplasms, Radiation-Induced -- epidemiology KW - Humans KW - Incidence KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Antineoplastic Agents -- adverse effects KW - Neoplasms, Multiple Primary -- etiology KW - Neoplasms, Multiple Primary -- pathology KW - Neoplasms, Multiple Primary -- epidemiology KW - Lymphoma, Non-Hodgkin -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80478753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Second+cancers+following+non-Hodgkin%27s+lymphoma.&rft.au=Travis%2C+L+B%3BCurtis%2C+R+E%3BBoice%2C+J+D%3BHankey%2C+B+F%3BFraumeni%2C+J+F&rft.aulast=Travis&rft.aufirst=L&rft.date=1991-04-01&rft.volume=67&rft.issue=7&rft.spage=2002&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-22 N1 - Date created - 1991-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acridine orange stain for determining intracellular enteropathogens in HeLa cells. AN - 72086226; 1716265 AB - Green-fluorescent intracellular enteropathogenic bacteria were observed after infected HeLa cell monolayers were stained with acridine orange and counterstained with crystal violet at least 3 h after infection. JF - Journal of clinical microbiology AU - Miliotis, M D AD - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 830 EP - 831 VL - 29 IS - 4 SN - 0095-1137, 0095-1137 KW - Fluorescent Dyes KW - 0 KW - Acridine Orange KW - F30N4O6XVV KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Humans KW - Enterobacteriaceae Infections -- diagnosis KW - HeLa Cells -- microbiology KW - Staining and Labeling KW - Enterobacteriaceae -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72086226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Acridine+orange+stain+for+determining+intracellular+enteropathogens+in+HeLa+cells.&rft.au=Miliotis%2C+M+D&rft.aulast=Miliotis&rft.aufirst=M&rft.date=1991-04-01&rft.volume=29&rft.issue=4&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-15 N1 - Date created - 1991-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1983 Apr;40(1):340-50 [6299962] Scand J Infect Dis Suppl. 1980;Suppl 24:86-92 [6111123] Infect Immun. 1979 Jun;24(3):879-86 [381204] S Afr Med J. 1978 Jan 21;53(3):93-4 [349716] Infect Immun. 1977 Aug;17(2):290-5 [330403] Can J Microbiol. 1977 Dec;23(12):1714-22 [597794] Infect Immun. 1976 Oct;14(4):851-7 [791864] J Clin Invest. 1973 Feb;52(2):441-53 [4630603] J Infect Dis. 1973 Jul;128(1):69-75 [4577975] Infect Immun. 1973 Sep;8(3):322-8 [4581006] N Engl J Med. 1971 Jul 1;285(1):1-9 [4996788] Jpn J Med Sci Biol. 1968 Oct;21(5):333-49 [4886582] J Bacteriol. 1964 Nov;88(5):1503-18 [16562000] Infect Immun. 1989 Jul;57(7):1928-35 [2659527] Infect Immun. 1987 Nov;55(11):2681-8 [3312007] J Clin Microbiol. 1985 Dec;22(6):897-902 [4066921] J Lab Clin Med. 1983 Aug;102(2):298-305 [6864075] Infect Immun. 1982 Mar;35(3):852-60 [6279518] Infect Immun. 1983 Feb;39(2):505-13 [6187681] J Med Microbiol. 1983 Feb;16(1):37-43 [6337262] N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Current intelligence bulletin 55. Carcinogenicity of acetaldehyde and malonaldehyde, and mutagenicity of related low-molecular-weight aldehydes. AN - 16235483; 2768926 AB - The National Institute for Occupational Safety and Health (NIOSH) has determined that acetaldehyde and malonaldehyde are potentially carcinogenic to occupationally exposed workers. NIOSH is also concerned about exposure to nine related low-molecular-weight aldehydes: acrolein, butyraldehyde, crotonaldehyde, glutaraldehyde, glyoxal, paraformaldehyde, propiolaldehyde, propionaldehyde, and valeraldehyde. Long-term inhalation studies of acetaldehyde produced laryngeal cancers in hamsters and nasal cancers in rats. JF - NTIS, SPRINGFIELD, VA (USA). 1991. Y1 - 1991/04// PY - 1991 DA - Apr 1991 PB - NTIS, SPRINGFIELD, VA (USA) KW - acetaldehyde KW - malonaldehyde KW - Health & Safety Science Abstracts; Risk Abstracts KW - carcinogenicity KW - mutagenicity KW - aldehydes KW - occupational exposure KW - R2 23080:Industrial and labor KW - H SI0.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16235483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Current+intelligence+bulletin+55.+Carcinogenicity+of+acetaldehyde+and+malonaldehyde%2C+and+mutagenicity+of+related+low-molecular-weight+aldehydes.&rft.title=Current+intelligence+bulletin+55.+Carcinogenicity+of+acetaldehyde+and+malonaldehyde%2C+and+mutagenicity+of+related+low-molecular-weight+aldehydes.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - NTIS Order No.: PB92-131697/GAR. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Video display terminals and the risk of spontaneous abortion. AN - 80457934; 1997838 AB - The relation between spontaneous abortion and the use of video display terminals (VDTs) is of great public health concern. Previous investigators of this issue have reported inconsistent findings. To determine whether electromagnetic fields emitted by VDTs are associated with an increased risk of spontaneous abortion, a cohort of female telephone operators who used VDTs at work was compared with a cohort of operators who did not use VDTs. To obtain reliable estimates of exposure, we determined the number of hours of VDT use per week from company records and measured electromagnetic fields at VDT workstations and, for purposes of comparison, at workstations without VDTs. Operators who used VDTs had higher abdominal exposure to very-low-frequency (15 kHz) electromagnetic fields (workstations without VDTs did not emit very-low-frequency energy). Abdominal exposure to extremely-low-frequency fields (45 to 60 Hz) was similar for both operators who used VDTs and those who did not. Among 2430 women interviewed, there were 882 pregnancies that met our criteria for inclusion in the study. We found no excess risk of spontaneous abortion among women who used VDTs during the first trimester of pregnancy (odds ratio = 0.93; 95 percent confidence interval, 0.63 to 1.38), and no dose-response relation was apparent when we examined the women's hours of VDT use per week (odds ratio for 1 to 25 hours per week = 1.04; 95 percent confidence interval, 0.61 to 1.79; odds ratio for greater than 25 hours per week = 1.00; 95 percent confidence interval, 0.61 to 1.64). There continued to be no risk associated with the use of VDTs when we accounted for multiple pregnancies, conducted separate analyses of early abortion, late abortion, and all fetal losses, or limited our analyses to spontaneous abortions for which a physician was consulted. The use of VDTs and exposure to the accompanying electromagnetic fields were not associated with an increased risk of spontaneous abortion in this study. JF - The New England journal of medicine AU - Schnorr, T M AU - Grajewski, B A AU - Hornung, R W AU - Thun, M J AU - Egeland, G M AU - Murray, W E AU - Conover, D L AU - Halperin, W E AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/03/14/ PY - 1991 DA - 1991 Mar 14 SP - 727 EP - 733 VL - 324 IS - 11 SN - 0028-4793, 0028-4793 KW - Abridged Index Medicus KW - Index Medicus KW - Regression Analysis KW - Electromagnetic Fields KW - Logistic Models KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Female KW - Pregnancy KW - Fetal Death KW - Occupational Exposure KW - Abortion, Spontaneous -- etiology KW - Computer Terminals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80457934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Video+display+terminals+and+the+risk+of+spontaneous+abortion.&rft.au=Schnorr%2C+T+M%3BGrajewski%2C+B+A%3BHornung%2C+R+W%3BThun%2C+M+J%3BEgeland%2C+G+M%3BMurray%2C+W+E%3BConover%2C+D+L%3BHalperin%2C+W+E&rft.aulast=Schnorr&rft.aufirst=T&rft.date=1991-03-14&rft.volume=324&rft.issue=11&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-01 N1 - Date created - 1991-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Sep 12;325(11):811-3 [1870658] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spina bifida in infants of women treated with carbamazepine during pregnancy. AN - 80444321; 1994251 JF - The New England journal of medicine AU - Rosa, F W AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD. Y1 - 1991/03/07/ PY - 1991 DA - 1991 Mar 07 SP - 674 EP - 677 VL - 324 IS - 10 SN - 0028-4793, 0028-4793 KW - Anticonvulsants KW - 0 KW - Carbamazepine KW - 33CM23913M KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Cohort Studies KW - Infant, Newborn KW - Anticonvulsants -- adverse effects KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Carbamazepine -- adverse effects KW - Spinal Dysraphism -- chemically induced KW - Pregnancy Complications -- drug therapy KW - Epilepsy -- drug therapy KW - Abnormalities, Drug-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80444321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Spina+bifida+in+infants+of+women+treated+with+carbamazepine+during+pregnancy.&rft.au=Rosa%2C+F+W&rft.aulast=Rosa&rft.aufirst=F&rft.date=1991-03-07&rft.volume=324&rft.issue=10&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-21 N1 - Date created - 1991-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Mar 7;324(10):690-1 [1994254] N Engl J Med. 1991 Aug 29;325(9):664-5 [1861708] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fumigants and related chemicals in foods: review of residue findings, contamination sources, and analytical methods. AN - 80653299; 2063187 AB - Public concern over chemical residues in foods increased in the United States during the early 1980s. Potentially hazardous levels of ethylene dibromide (EDB), a relatively non-volatile fumigant, were detected in several finished grain-based products by governmental food-monitoring laboratories. As a result, the U.S. Environmental Protection Agency banned the use of EDB as a fumigant in 1983. Commercial fumigators then began using more of the highly volatile chemicals such as methyl bromide and phosphine. These chemicals are less likely to leave residues on stored crops than the previously used fumigants such as EDB, chloroform, and carbon tetrachloride. However, trace residues of many pest-control fumigants and related industrial chemicals are currently found in assorted foods. This contamination may come from the original fumigation of stored crops, or from the industrial chemicals occurring in the environment and in food processing chains. No potential health problem is indicated at this time. Yet scientists continue to uncover the sources of this chemical contamination, and to develop better methods to monitor foods for it. They also seek better ways to protect foodstuffs from pests prior to human consumption. JF - The Science of the total environment AU - Daft, J L AD - US Department of Health and Human Service, Food and Drug Administration, Kansas City, MO 64106. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 501 EP - 518 VL - 100 Spec No SN - 0048-9697, 0048-9697 KW - Solvents KW - 0 KW - Ethylene Dibromide KW - 1N41638RNO KW - Index Medicus KW - United States KW - Solvents -- toxicity KW - United States Environmental Protection Agency KW - Humans KW - Food Analysis KW - Food Handling KW - Ethylene Dibromide -- toxicity KW - Food Contamination KW - Fumigation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80653299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Fumigants+and+related+chemicals+in+foods%3A+review+of+residue+findings%2C+contamination+sources%2C+and+analytical+methods.&rft.au=Daft%2C+J+L&rft.aulast=Daft&rft.aufirst=J&rft.date=1991-03-01&rft.volume=100+Spec+No&rft.issue=&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=00489697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-05 N1 - Date created - 1991-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung particulate burdens of subjects from the Cincinnati, Ohio urban area. AN - 80628084; 1647057 AB - Because of the relatively small data base existing for lung particulate burdens of subjects with no overt pneumoconioses, the total exogenous lung particulate concentrations of 91 subjects from the Cincinnati, Ohio urban area were determined using an automated scanning electron microscope-energy dispersive x-ray analysis-image analysis system. Four of these subjects were foundry workers and had the highest exogenous particle concentrations seen in the 91 lungs, ranging from 1860 to 2990 x 10(6) particles per gram of dry lung (ppg). The average exogenous particle concentration for the remaining 87 subjects was 476 +/- 380 x 10(6) ppg with a range of 71 to 1860 x 10(6) ppg. The median size of the exogenous particles in the 87 lungs was narrow, ranging from 0.37 to 1.02 microns. The geometric mean particle size over all 87 lungs was 0.60 microns with a geometric standard deviation (sigma g) of 2.35. The total exogenous particle levels were elevated for the male subjects compared to females (p=0.015), and were positively associated with age (p=0.021). However, no correlation was seen between total particle concentration and race or smoking history. JF - Scanning microscopy AU - Stettler, L E AU - Platek, S F AU - Riley, R D AU - Mastin, J P AU - Simon, S D AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 85 EP - 92; discussion 92-4 VL - 5 IS - 1 SN - 0891-7035, 0891-7035 KW - Coal KW - 0 KW - Dust KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Pneumoconiosis -- etiology KW - Particle Size KW - Humans KW - Pneumoconiosis -- epidemiology KW - Ohio -- epidemiology KW - Aged KW - Smoking KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Mining KW - Urban Population KW - Female KW - Male KW - Microscopy, Electron, Scanning KW - Lung -- chemistry KW - Lung -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80628084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+microscopy&rft.atitle=Lung+particulate+burdens+of+subjects+from+the+Cincinnati%2C+Ohio+urban+area.&rft.au=Stettler%2C+L+E%3BPlatek%2C+S+F%3BRiley%2C+R+D%3BMastin%2C+J+P%3BSimon%2C+S+D&rft.aulast=Stettler&rft.aufirst=L&rft.date=1991-03-01&rft.volume=5&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Scanning+microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of benzene in polypropylene food-packaging materials and food-contact paraffin waxes. AN - 80621124; 2050616 AB - An analytical procedure was developed for determination of benzene in polypropylene food packaging and was adapted for determination of benzene in commercial paraffin waxes intended for food-contact use. The polymer was dissolved in hexadecane at 150 degrees C. The wax was melted in an 80 degrees C oven. A simple helium-sparging apparatus was used to remove the volatile chemical from the polymer or wax. The contaminant was collected in methanol, distilled water was added, and the resulting solution was analyzed by headspace gas chromatography. The instrument was equipped with a 30 m fused silica open tubular capillary column and a photoionization detector. Average recoveries of benzene from polymer and paraffin wax at low parts-per-billion concentrations were 63 and 70%, respectively. Limits of detection and quantitation for analysis of polypropylene were 8 and 17 ppb, respectively; the limit of quantitation for analysis of paraffin wax was 2 ppb. In several commercial polypropylene products examined, benzene levels ranged from none detected to 426 ppb. In 3 commercial waxes examined, concentrations of 16-73 ppb benzene were determined. The presence of benzene was confirmed by gas chromatography/mass spectrometry. JF - Journal - Association of Official Analytical Chemists AU - Varner, S L AU - Hollifield, H C AU - Andrzejewski, D AD - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204. PY - 1991 SP - 367 EP - 374 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Polypropylenes KW - 0 KW - Paraffin KW - 8002-74-2 KW - Benzene KW - J64922108F KW - Index Medicus KW - Spectrophotometry, Infrared KW - Reference Standards KW - Gas Chromatography-Mass Spectrometry KW - Food Contamination -- prevention & control KW - Benzene -- analysis KW - Polypropylenes -- analysis KW - Paraffin -- analysis KW - Food Handling -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80621124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Determination+of+benzene+in+polypropylene+food-packaging+materials+and+food-contact+paraffin+waxes.&rft.au=Varner%2C+S+L%3BHollifield%2C+H+C%3BAndrzejewski%2C+D&rft.aulast=Varner&rft.aufirst=S&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food and Drug Administration pesticide residue monitoring of foods: 1983-1986. AN - 80619811; 2050609 AB - Pesticide residues in foods are reported for the 4-year period 1982-1986 [fiscal years (FY) 83-86]. Results were summarized from the 2 complementary approaches that make up the Food and Drug Administration's (FDA) pesticide residue monitoring program. Under regulatory monitoring, which focuses on residues in raw agricultural commodities, a total of 49,055 samples (27,700 domestic and 21,355 import) that included fresh fruits and vegetables, grains and grain products, milk and dairy products, seafoods, and a variety of processed foods were analyzed. No residues were found in 60 and 48% of the domestic and import samples, respectively, compared with 55 and 44% in FY78-82. About 3% of the domestic and 5% of the import samples were violative. In FY78-82, about 3 and 7% were violative, respectively. The other FDA monitoring approach, the Total Diet Study, was revised in April 1982 to expand coverage of age/sex groups, use updated diets, and provide for analysis of individual foods. Results from monitoring under this modified approach and from regulatory monitoring continued to demonstrate that pesticide residues in the U.S. food supply were well below regulatory limits, and dietary intakes were many times lower than the Acceptable Daily Intakes established by international agencies. JF - Journal - Association of Official Analytical Chemists AU - Yess, N J AU - Houston, M G AU - Gunderson, E L AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 273 EP - 280 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Data Collection -- methods KW - Diet KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80619811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Food+and+Drug+Administration+pesticide+residue+monitoring+of+foods%3A+1983-1986.&rft.au=Yess%2C+N+J%3BHouston%2C+M+G%3BGunderson%2C+E+L&rft.aulast=Yess&rft.aufirst=N&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food and Drug Administration pesticide residue monitoring of foods: 1978-1982. AN - 80619742; 2050608 AB - Pesticide residues in foods are reported for the 5-year period 1978-1982 [fiscal years (FY) 78-82]. Results were compiled from the 2 complementary elements that comprise the Food and Drug Administration's (FDA) program for monitoring pesticide residues in foods. Under regulatory monitoring, which focuses on residues in raw agricultural commodities, a total of 49,877 samples (30,361 domestic and 19,516 import) that included fresh fruits and vegetables, grains, milk and dairy products, seafoods, and a variety of processed foods were analyzed. No residues were found in about 55 and 44% of the domestic and import samples, respectively. About 3% of the domestic and 7% of the import samples were classed as violative. Data from the Total Diet Study, which is conducted to determine dietary intakes of a variety of chemicals, showed that residues of 42 pesticides were found in 1044 composites of table-ready foods. Results of FDA's monitoring for FY78-82 demonstrate that pesticide residue levels in the U.S. food supply were generally well below regulatory limits, and dietary intakes were manyfold lower than the Acceptable Daily Intakes established by international agencies. JF - Journal - Association of Official Analytical Chemists AU - Yess, N J AU - Houston, M G AU - Gunderson, E L AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 265 EP - 272 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Data Collection -- methods KW - Diet KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80619742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Food+and+Drug+Administration+pesticide+residue+monitoring+of+foods%3A+1978-1982.&rft.au=Yess%2C+N+J%3BHouston%2C+M+G%3BGunderson%2C+E+L&rft.aulast=Yess&rft.aufirst=N&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunoassay of pesticides. AN - 80617092; 2050606 AB - Determination of the presence and levels of pesticide residues in food is fundamental in monitoring and regulatory programs. Residues are separated from the food matrix by solvent extraction, followed by cleanup steps. The residues are most often identified and quantitated by instrumental analysis, usually liquid or gas chromatography. Extraction and cleanup are often laborious and time-consuming; determination requires expensive, sophisticated instrumentation. There is a need for rapid, easily performed tests, such as immunoassays, that could be used for screening under field conditions or for quantitation of residues in foods in the laboratory. Although a large number of immunoassays have been developed for pesticide chemicals, very few have been specifically applied to foods, and only a very small number are currently available commercially. The agencies charged with monitoring and regulatory responsibilities--Environmental Protection Agency, Food and Drug Administration, and U.S. Department of Agriculture--as well as professional societies such as AOAC and the International Union of Pure and Applied Chemistry, are investigating and developing guidelines for test kit evaluation and standards to be met before a kit can be accepted as a practical and useful method of analysis for use in their programs. JF - Journal - Association of Official Analytical Chemists AU - Kaufman, B M AU - Clower, M AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 239 EP - 247 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - Immunoassay -- methods KW - Immunoenzyme Techniques KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80617092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Immunoassay+of+pesticides.&rft.au=Kaufman%2C+B+M%3BClower%2C+M&rft.aulast=Kaufman&rft.aufirst=B&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of dose-response relationships inferred by statistically significant trend tests. AN - 80613135; 2049495 AB - A method is proposed for classifying various experimental outcomes associated with statistically significant trend tests according to a set of sequential testing within a family of closed (under intersections) one-sided tests. The intent of the procedure is to characterize the general shape of implied dose-response relationships, taking care neither to inflate the false-positive (Type I) error rate by overtesting, nor to sacrifice power by overadjusting for multiple comparisons. JF - Biometrics AU - Kodell, R L AU - Chen, J J AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 139 EP - 146 VL - 47 IS - 1 SN - 0006-341X, 0006-341X KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Carcinogens -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity KW - Data Interpretation, Statistical KW - Biometry KW - Dose-Response Relationship, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80613135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Characterization+of+dose-response+relationships+inferred+by+statistically+significant+trend+tests.&rft.au=Kodell%2C+R+L%3BChen%2C+J+J&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-03-01&rft.volume=47&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Polymerase chain reaction identification of Vibrio vulnificus in artificially contaminated oysters. AN - 80580430; 2039231 AB - DNAs extracted from Vibrio vulnificus seeded into oyster homogenates were evaluated as templates for the polymerase chain reaction. Several extraction procedures were examined, and it was determined that DNA recovered from cells lysed by guanidine isothiocyanate, extracted with chloroform, and precipitated with ethanol was most suitable for use as a polymerase chain reaction template. The region targeted was a 519-bp portion of the cytotoxin-hemolysin gene of V. vulnificus. This region was amplified only when DNA from this species was present in the homogenate. V. vulnificus seeded into oyster homogenates at an initial level of 10(2) CFU/g of oyster meat was consistently observed after 24 h of incubation in alkaline peptone water. JF - Applied and environmental microbiology AU - Hill, W E AU - Keasler, S P AU - Trucksess, M W AU - Feng, P AU - Kaysner, C A AU - Lampel, K A AD - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 707 EP - 711 VL - 57 IS - 3 SN - 0099-2240, 0099-2240 KW - DNA, Bacterial KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Polymerase Chain Reaction KW - Animals KW - Base Sequence KW - DNA, Bacterial -- isolation & purification KW - DNA, Bacterial -- genetics KW - Molecular Sequence Data KW - Ostreidae -- microbiology KW - Vibrio -- genetics KW - Food Contamination KW - Vibrio -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80580430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Polymerase+chain+reaction+identification+of+Vibrio+vulnificus+in+artificially+contaminated+oysters.&rft.au=Hill%2C+W+E%3BKeasler%2C+S+P%3BTrucksess%2C+M+W%3BFeng%2C+P%3BKaysner%2C+C+A%3BLampel%2C+K+A&rft.aulast=Hill&rft.aufirst=W&rft.date=1991-03-01&rft.volume=57&rft.issue=3&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-02 N1 - Date created - 1991-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Nucleic Acids Res. 1976 Sep;3(9):2303-8 [987581] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Infect Immun. 1985 Apr;48(1):62-72 [3980095] Infect Immun. 1985 Dec;50(3):922-4 [4066036] Science. 1985 Dec 20;230(4732):1350-4 [2999980] Am J Med. 1986 Feb;80(2):336-8 [3946453] Appl Environ Microbiol. 1985 Dec;50(6):1548-9 [4091570] Appl Environ Microbiol. 1987 Jan;53(1):193-5 [3827248] Appl Environ Microbiol. 1987 Jun;53(6):1349-51 [3606112] Appl Environ Microbiol. 1987 Oct;53(10):2588-9 [3426222] Science. 1988 Jan 29;239(4839):487-91 [2448875] Mol Cell Probes. 1988 Mar;2(1):47-57 [3288864] Ann Intern Med. 1988 Aug 15;109(4):318-23 [3260760] J Clin Microbiol. 1989 Feb;27(2):261-5 [2644292] Mol Cell Probes. 1988 Sep;2(3):189-95 [3221883] Appl Environ Microbiol. 1990 Feb;56(2):307-14 [2306085] J Assoc Off Anal Chem. 1990 Mar-Apr;73(2):248-56 [2324035] Infect Immun. 1990 Aug;58(8):2706-9 [2370116] Appl Environ Microbiol. 1990 Jun;56(6):1536-40 [2200336] Lett Appl Microbiol. 1990 Jan;10(1):31-4 [1366574] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preventing adverse health effects from exposure to dimethylformamide (DMF). AN - 80562385; 2028916 JF - American Industrial Hygiene Association journal AU - NIOSH AD - NIOSH Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 2 EP - A160, A162 VL - 52 IS - 3 SN - 0002-8894, 0002-8894 KW - Solvents KW - 0 KW - Dimethylformamide KW - 8696NH0Y2X KW - Index Medicus KW - United States KW - Chemical and Drug Induced Liver Injury -- etiology KW - Maximum Allowable Concentration KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure KW - Dimethylformamide -- adverse effects KW - Liver -- enzymology KW - Liver -- drug effects KW - Solvents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80562385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Preventing+adverse+health+effects+from+exposure+to+dimethylformamide+%28DMF%29.&rft.au=NIOSH&rft.aulast=NIOSH&rft.aufirst=&rft.date=1991-03-01&rft.volume=52&rft.issue=3&rft.spage=A160&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The magnitude of the tissue residue problem with regard to consumer needs. AN - 80548087; 2026525 JF - Journal of the American Veterinary Medical Association AU - Guest, G B AU - Paige, J C AD - US Department of Health and Human Services, Food and Drug Administration, Center for Veterinary Medicine, Rockville, MD 20857. Y1 - 1991/03/01/ PY - 1991 DA - 1991 Mar 01 SP - 805 EP - 808 VL - 198 IS - 5 SN - 0003-1488, 0003-1488 KW - Anti-Bacterial Agents KW - 0 KW - Hormones KW - Sulfamethazine KW - 48U51W007F KW - Index Medicus KW - United States KW - Sulfamethazine -- analysis KW - Animals KW - Hormones -- analysis KW - Anti-Bacterial Agents -- analysis KW - Food Inspection KW - Meat -- standards KW - United States Food and Drug Administration KW - Consumer Product Safety KW - Drug Residues -- analysis KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80548087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Veterinary+Medical+Association&rft.atitle=The+magnitude+of+the+tissue+residue+problem+with+regard+to+consumer+needs.&rft.au=Guest%2C+G+B%3BPaige%2C+J+C&rft.aulast=Guest&rft.aufirst=G&rft.date=1991-03-01&rft.volume=198&rft.issue=5&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Veterinary+Medical+Association&rft.issn=00031488&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative regioselective and stereoselective metabolism of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene by mouse and rat liver microsomes. AN - 80492811; 2009583 AB - Quantitative metabolism of 7-chlorobenz[a]anthracene (7-Cl-BA) and 7-bromobenz[a]anthracene (7-Br-BA) by liver microsomes of uninduced mice and rats was studied. Both enzymatic systems metabolize 7-Cl-BA preferentially at the C-8 and C-9 aromatic double bond region, approximately 42 and approximately 56% respectively, of the total metabolites. 7-Cl-BA and 7-Br-BA were metabolized considerably at C-3 and C-4, C-5 and C-6, C-8 and C-9, and C-10 and C-11. While 7-Cl-BA trans-3,4-dihydrodiol was formed in a 7-8% yield of the total metabolites in both enzymatic systems, 7-Br-BA trans-3,4-dihydrodiol was formed 16.0 and 9.9% respectively, from the mouse and rat liver microsomal metabolism. In mutagenicity assays with the Salmonella typhimurium tester strain TA100 in the presence of S9 activation enzymes, both of these trans-3,4-dihydrodiols exhibited higher mutagenicity than 7-Cl-BA and 7-Br-BA, while the other trans-dihydrodiol metabolites were either essentially inactive or weaker than the parent compounds. These results suggest that 7-Cl-BA trans-3,4-dihydrodiol and 7-Br-BA trans-3,4-dihydrodiol are the proximate metabolites of 7-Cl-BA and 7-Br-BA. Metabolism of 7-Cl-BA and 7-Br-BA by mouse liver microsomes was also in a stereoselective manner, preferentially giving trans-dihydrodiol metabolites an R, R stereochemistry. JF - Carcinogenesis AU - Fu, P P AU - Von Tungeln, L S AU - Unruh, L E AU - Ni, Y C AU - Chou, M W AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 371 EP - 378 VL - 12 IS - 3 SN - 0143-3334, 0143-3334 KW - Anthracenes KW - 0 KW - Benz(a)Anthracenes KW - Mutagens KW - 7-chlorobenz(a)anthracene KW - 20268-52-4 KW - 7-bromobenzanthracene KW - 32795-84-9 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Stereoisomerism KW - Mutagenicity Tests -- methods KW - Mutagens -- metabolism KW - Chromatography, High Pressure Liquid -- methods KW - Salmonella typhimurium -- drug effects KW - Mice KW - Salmonella typhimurium -- genetics KW - Male KW - Anthracenes -- metabolism KW - Microsomes, Liver -- metabolism KW - Benz(a)Anthracenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80492811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Comparative+regioselective+and+stereoselective+metabolism+of+7-chlorobenz%5Ba%5Danthracene+and+7-bromobenz%5Ba%5Danthracene+by+mouse+and+rat+liver+microsomes.&rft.au=Fu%2C+P+P%3BVon+Tungeln%2C+L+S%3BUnruh%2C+L+E%3BNi%2C+Y+C%3BChou%2C+M+W&rft.aulast=Fu&rft.aufirst=P&rft.date=1991-03-01&rft.volume=12&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-07 N1 - Date created - 1991-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Silicosis and lung cancer in U.S. metal miners. AN - 80482126; 2006898 AB - The association between silicosis and lung cancer mortality was estimated in 9,912 (369 silicotics and 9,543 nonsilicotics) white male metal miners. These miners were examined by the U.S. Public Health Service during 1959-1961 and were followed through 1975. Miners were excluded from this study if they were employed in a mine during 1959-1961 that used diesel equipment underground. The ores that were mined consisted of copper, lead-zinc, iron, mercury, lead silver, gold and gold-silver, tungsten, and molybenum. The standardized mortality ratio (SMR, U.S. white male rates) for lung cancer was 1.73 (95% CI: .94-2.90) in silicotics and 1.18 (95% CI: .98-1.42) in nonsilicotics. Additionally, SMRs were higher in silicotics than in nonsilicotics, even in most subgroups stratified by cigarette smoking habit, type of ore mined, years of service in an underground job, radon exposure group, or year of hire. When lung cancer mortality between silicotics and nonsilicotics was compared, the age-adjusted rate ratio (95% CI) was 1.56 (.91-2.68), and the age- and smoking-adjusted rate ratio was 1.96 (.98-3.67). Corresponding figures for miners who were employed in mines with low levels of radon exposure were 1.90 (.98-3.67) and 2.59 (1.44-4.68), respectively. These findings indicate that lung cancer mortality risk was increased in silicotics, and this probably did not result from chance or bias. However, confounding from radon exposure could not be ruled out. The findings indicate that further follow-up of this cohort is needed. JF - Archives of environmental health AU - Amandus, H AU - Costello, J AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia. PY - 1991 SP - 82 EP - 89 VL - 46 IS - 2 SN - 0003-9896, 0003-9896 KW - Radon KW - Q74S4N8N1G KW - Abridged Index Medicus KW - Index Medicus KW - Causality KW - Occupational Exposure KW - United States Public Health Service KW - Humans KW - Radon -- adverse effects KW - Smoking -- epidemiology KW - Cause of Death KW - Comorbidity KW - Risk Factors KW - Cohort Studies KW - Confounding Factors (Epidemiology) KW - Radiography KW - Bias (Epidemiology) KW - United States -- epidemiology KW - Male KW - Silicosis -- diagnostic imaging KW - Occupational Diseases -- diagnostic imaging KW - Lung Neoplasms -- epidemiology KW - Silicosis -- mortality KW - Silicosis -- epidemiology KW - Occupational Diseases -- epidemiology KW - Lung Neoplasms -- mortality KW - Mining KW - Lung Neoplasms -- diagnostic imaging KW - Metallurgy KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80482126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Silicosis+and+lung+cancer+in+U.S.+metal+miners.&rft.au=Amandus%2C+H%3BCostello%2C+J&rft.aulast=Amandus&rft.aufirst=H&rft.date=1991-03-01&rft.volume=46&rft.issue=2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-19 N1 - Date created - 1991-04-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Tissue doses in the upper gastrointestinal fluoroscopy examination. AN - 80442540; 1994397 AB - A method was developed to estimate tissue doses from the upper gastrointestinal fluoroscopy examination. It involved measuring the technical parameters of the clinical examination, partitioning the dynamic examination into a set of discrete x-ray fields, and generating corresponding tissue does tables with an existing computer program. Knowledge of the radiation exposures associated with each of the fields enabled the calculation of tissue doses for the entire dynamic examination. In this limited sample (eight patients), fluoroscopy times ranged from 108 to 183 seconds. Radiation exposures ranged from 2.3 to 7.2 mC/kg (9.1-28 R), thyroid doses from 0.15 to 3.5 mGy (15-350 mrad), uterine doses from 0.16 to 1.0 mGy (16-100 mrad), lung doses from 0.90 to 4.2 mGy (90-420 mrad), and active bone marrow doses from 0.81 to 5.4 mGy (81-540 mrad). JF - Radiology AU - Suleiman, O H AU - Anderson, J AU - Jones, B AU - Rao, G U AU - Rosenstein, M AD - Office of Training and Assistance, Food and Drug Administration, Rockville, Md. 20857. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 653 EP - 658 VL - 178 IS - 3 SN - 0033-8419, 0033-8419 KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Exposure KW - Radiometry KW - Maximum Allowable Concentration KW - Humans KW - Environmental Exposure KW - Time Factors KW - Radiation Dosage KW - Radiation Protection KW - Digestive System -- diagnostic imaging KW - Fluoroscopy -- methods KW - Fluoroscopy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80442540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Tissue+doses+in+the+upper+gastrointestinal+fluoroscopy+examination.&rft.au=Suleiman%2C+O+H%3BAnderson%2C+J%3BJones%2C+B%3BRao%2C+G+U%3BRosenstein%2C+M&rft.aulast=Suleiman&rft.aufirst=O&rft.date=1991-03-01&rft.volume=178&rft.issue=3&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-21 N1 - Date created - 1991-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Radiology. 1991 Mar;178(3):622-3 [1994387] Erratum In: Radiology 1991 Jun;179(3):881 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 80436049; 1899454 JF - JAMA AU - Nightingale, S L AD - Office of Health Affairs, FDA, Rockville, MD 20857. Y1 - 1991/02/20/ PY - 1991 DA - 1991 Feb 20 SP - 847 VL - 265 IS - 7 SN - 0098-7484, 0098-7484 KW - Contraceptive Agents, Female KW - 0 KW - Cyanides KW - Drug Implants KW - Nitroprusside KW - 169D1260KM KW - Norgestrel KW - 3J8Q1747Z2 KW - Levonorgestrel KW - 5W7SIA7YZW KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Prosthesis Failure KW - United States Food and Drug Administration KW - Humans KW - Cyanides -- poisoning KW - Heart Valve Prosthesis KW - Nitroprusside -- adverse effects KW - Contraceptive Agents, Female -- administration & dosage KW - Drug Labeling KW - Norgestrel -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80436049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1991-02-20&rft.volume=265&rft.issue=7&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-13 N1 - Date created - 1991-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Correlation of pharmacokinetic data with endpoints of developmental toxicity. AN - 80632496; 2055352 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Young, J F AD - Division of Reproductive and Developmental Toxicology, Food and Drug Administration, DHHS, Jefferson, Arkansas 72079. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 222 EP - 224 VL - 16 IS - 2 SN - 0272-0590, 0272-0590 KW - Teratogens KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Data Interpretation, Statistical KW - Research Design KW - Teratogens -- pharmacokinetics KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80632496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Correlation+of+pharmacokinetic+data+with+endpoints+of+developmental+toxicity.&rft.au=Young%2C+J+F&rft.aulast=Young&rft.aufirst=J&rft.date=1991-02-01&rft.volume=16&rft.issue=2&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-26 N1 - Date created - 1991-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the onset and duration of response to cold air inhalation challenge in cynomolgus monkeys (Macaca fascicularis). AN - 80539273; 2022812 AB - Cold air inhalation challenge (CAIC) for the evaluation of bronchial reactivity has been proposed as a physical agent alternative to chemical agent challenges (methacholine or histamine), especially suitable for the occupational environment. The present investigation describes and evaluates a method for performing cold air inhalation challenge in Cynomolgus monkeys (Macaca fascicularis), a species shown to be useful in animal modeling studies of occupational asthma. Six adult male anesthetized monkeys were ventilated by changes in external pressure while breathing cold air (-25 degrees C to -30 degrees C). Pulmonary function testing was performed at 10, 25, 40 and 55 min post-challenge. Significant increases (P less than 0.05) in average pulmonary flow resistance (RL) and decreases in dynamic compliance (CL dyn) were observed, with maximum impairment occurring at 25 min post-challenge, with a trend towards a return to baseline values at 55 min post-challenge. Peak expiratory flow rate (PEFR), forced expiratory volume in 0.5 s/forced vital capacity (FEV0.5/FVC) and forced expiratory flow at 50% forced vital capacity (FEF50) showed the same general pattern of reduction as seen with RL; however, these results were not statistically significant, most probably owing to individual monkey variability and the small number of monkeys (N = 6) used. A repeat challenge at 25 min after a primary challenge yielded increased RL in one monkey, suggesting that no absolute refractory period is present from CAIC. Results of these studies demonstrate that CAIC causes bronchoconstriction in monkeys and may be useful in further animal modeling studies designed to determine the asthmogenic/airway irritant potential of occupational toxicants. JF - Journal of applied toxicology : JAT AU - Biagini, R E AU - Clark, J C AU - Moorman, W J AU - Knecht, E A AD - Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 1 EP - 6 VL - 11 IS - 1 SN - 0260-437X, 0260-437X KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Index Medicus KW - Methacholine Chloride -- pharmacology KW - Animals KW - Airway Resistance KW - Lung -- drug effects KW - Lung -- physiology KW - Male KW - Macaca fascicularis -- physiology KW - Bronchoconstriction KW - Cold Temperature KW - Air UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80539273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Evaluation+of+the+onset+and+duration+of+response+to+cold+air+inhalation+challenge+in+cynomolgus+monkeys+%28Macaca+fascicularis%29.&rft.au=Biagini%2C+R+E%3BClark%2C+J+C%3BMoorman%2C+W+J%3BKnecht%2C+E+A&rft.aulast=Biagini&rft.aufirst=R&rft.date=1991-02-01&rft.volume=11&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-05 N1 - Date created - 1991-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung cancer in mild steel welders. AN - 80466066; 2000839 AB - To investigate lung cancer risk, the authors conducted a historical cohort mortality study of 4,459 mild steel welders who had been employed at three midwestern plants which manufactured heavy equipment. Follow-up began in the mid-1950s and extended through 1988. All welders had at least 2 years welding experience (average duration, 8.5 years). This cohort had no occupational exposure to asbestos or stainless steel fumes (containing nickel and chromium), two potential confounders in previous welders studies. A comparison population of 4,286 nonwelders, all with at least 2 years employment at the same plants, was also studied. Nonwelders had never been welders and were allowed to have no more than 90 days employment as a painter, foundryman, or machinist. Sampling data collected from 1974-1987 indicated that welders were exposed to 6-7 mg/m3 of total particulate and 3-4 mg/m3 of iron oxide, while nonwelders had negligible exposures to welding fumes. When compared with the United States population, both welders and nonwelders had elevated rates for lung cancer (standardized mortality ratios (SMRs): welders, SMR = 1.07; nonwelders, SMR = 1.17), but neither SMR was significantly elevated. Limited smoking data based on a 1985 survey indicated that both welders and nonwelders smoked more than the United States population, possibly accounting for part of their elevated lung cancer rates. There was no trend of increased risk for welders with increased duration of exposure. The only other cause of death significantly elevated was emphysema among welders. Nonmalignant respiratory disease was not elevated for welders (SMR = 0.96). When welders were compared with nonwelders directly for lung cancer, the rate ratio was 0.90. JF - American journal of epidemiology AU - Steenland, K AU - Beaumont, J AU - Elliot, L AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/02/01/ PY - 1991 DA - 1991 Feb 01 SP - 220 EP - 229 VL - 133 IS - 3 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Cohort Studies KW - United States -- epidemiology KW - Time Factors KW - Smoking -- epidemiology KW - Male KW - Cause of Death KW - Occupational Exposure KW - Lung Neoplasms -- epidemiology KW - Welding KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80466066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Lung+cancer+in+mild+steel+welders.&rft.au=Steenland%2C+K%3BBeaumont%2C+J%3BElliot%2C+L&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-02-01&rft.volume=133&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-08 N1 - Date created - 1991-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recommended protocols based on a survey of current practice in genotoxicity testing laboratories: III. Cell transformation in C3H/10T1/2 mouse embryo cell, BALB/c 3T3 mouse fibroblast and Syrian hamster embryo cell cultures. AN - 80450593; 1996125 AB - A standardized protocol and guidelines for the performance of cell transformation testing in mouse embryo (C3H/10T1/2), mouse fibroblast (BALB/c 3T3) and Syrian hamster embryo (SHE) cells have been developed. The protocol is based primarily on current laboratory practices as determined by responses to a detailed questionnaire completed by North American and European governmental, university and contract laboratories involved with cell transformation experimentation. This report identifies those modifications to previously described methodologies which are being used on a regular basis and also serves to clarify confusing or inconsistent practices. JF - Mutation research AU - Dunkel, V C AU - Rogers, C AU - Swierenga, S H AU - Brillinger, R L AU - Gilman, J P AU - Nestmann, E R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 285 EP - 300 VL - 246 IS - 2 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Cells, Cultured KW - Mice KW - Cricetinae KW - Mutagenicity Tests -- methods KW - Cell Transformation, Neoplastic -- drug effects KW - Mutagenicity Tests -- standards KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80450593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Recommended+protocols+based+on+a+survey+of+current+practice+in+genotoxicity+testing+laboratories%3A+III.+Cell+transformation+in+C3H%2F10T1%2F2+mouse+embryo+cell%2C+BALB%2Fc+3T3+mouse+fibroblast+and+Syrian+hamster+embryo+cell+cultures.&rft.au=Dunkel%2C+V+C%3BRogers%2C+C%3BSwierenga%2C+S+H%3BBrillinger%2C+R+L%3BGilman%2C+J+P%3BNestmann%2C+E+R&rft.aulast=Dunkel&rft.aufirst=V&rft.date=1991-02-01&rft.volume=246&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-22 N1 - Date created - 1991-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Mutat Res. 1991 Feb;246(2):227-33 [1996122] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. AN - 80437904; 1992763 AB - Acetaminophen overdose causes severe hepatotoxicity in humans and laboratory animals, presumably by metabolism to N-acetyl-p-benzoquinone imine: and binding to cysteine groups as 3-(cystein-S-yl)acetaminophen-protein adduct. Antiserum specific for the adduct was used immunohistochemically to demonstrate the formation, distribution, and concentration of this specific adduct in livers of treated mice and was correlated with cell injury as a function of dose and time. Within the liver lobule, immunohistochemically demonstrable adduct occurred in a temporally progressive, central-to-peripheral pattern. There was concordance between immunohistochemical staining and quantification of the adduct in hepatic 10,000g supernate, using a quantitative particle concentration fluorescence immunoassay. Findings include: 1) immunochemically detectable adduct before the appearance of centrilobular necrosis, 2) distinctive lobular zones of adduct localization with subsequent depletion during the progression of toxicity, 3) drug-protein binding in hepatocytes at subhepatotoxic doses and before depletion of total hepatic glutathione, 4) immunohistochemical evidence of drug binding in the nucleus, and 5) adduct in metabolically active and dividing hepatocytes and in macrophagelike cells in the regenerating liver. JF - The American journal of pathology AU - Roberts, D W AU - Bucci, T J AU - Benson, R W AU - Warbritton, A R AU - McRae, T A AU - Pumford, N R AU - Hinson, J A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 359 EP - 371 VL - 138 IS - 2 SN - 0002-9440, 0002-9440 KW - Acetaminophen KW - 362O9ITL9D KW - 3-(cystein-S-yl)paracetamol KW - 6Q2X58Y8BP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Mice KW - Tissue Distribution KW - Time Factors KW - Immunohistochemistry KW - Male KW - Liver -- pathology KW - Liver -- drug effects KW - Liver -- metabolism KW - Acetaminophen -- analogs & derivatives KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80437904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Immunohistochemical+localization+and+quantification+of+the+3-%28cystein-S-yl%29-acetaminophen+protein+adduct+in+acetaminophen+hepatotoxicity.&rft.au=Roberts%2C+D+W%3BBucci%2C+T+J%3BBenson%2C+R+W%3BWarbritton%2C+A+R%3BMcRae%2C+T+A%3BPumford%2C+N+R%3BHinson%2C+J+A&rft.aulast=Roberts&rft.aufirst=D&rft.date=1991-02-01&rft.volume=138&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-14 N1 - Date created - 1991-03-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1971 Mar 13;1(7698):519-22 [4100436] Biochem Pharmacol. 1990 Aug 1;40(3):573-9 [2200409] J Pharmacol Exp Ther. 1973 Oct;187(1):195-202 [4746327] Biochem Pharmacol. 1974 Oct 15;23(20):2785-94 [4429585] Br Med J. 1966 Aug 27;2(5512):497-9 [5913083] Br J Pharmacol Chemother. 1966 Mar;26(3):606-14 [5959211] Anal Biochem. 1969 Mar;27(3):502-22 [4388022] Anal Biochem. 1976 May 7;72:248-54 [942051] JAMA. 1976 Dec 13;236(24):2777-8 [1036573] Clin Chem. 1978 Jan;24(1):58-73 [22409] Biochem Pharmacol. 1981 Sep 15;30(18):2513-20 [7306203] Drug Metab Dispos. 1982 Jan-Feb;10(1):47-50 [6124382] J Med Chem. 1982 Jul;25(7):753-65 [7050382] J Med Chem. 1982 Aug;25(8):885-6 [7120276] Isr J Med Sci. 1984 Feb;20(2):145-7 [6706539] Proc Natl Acad Sci U S A. 1984 Mar;81(5):1327-31 [6424115] Mol Pharmacol. 1985 May;27(5):566-73 [3990678] Chem Biol Interact. 1985 Feb-Apr;53(1-2):155-72 [3995650] Blood. 1985 Aug;66(2):306-11 [4040409] Br Med J (Clin Res Ed). 1985 Oct 5;291(6500):938-9 [3929972] J Biol Chem. 1987 Jan 25;262(3):974-80 [3100532] J Pharmacol Exp Ther. 1987 May;241(2):527-33 [3572810] Biochem Pharmacol. 1987 Apr 15;36(8):1193-6 [3593409] Hepatology. 1987 Nov-Dec;7(6):1210-4 [2445642] Carcinogenesis. 1988 Jan;9(1):59-63 [3335048] Toxicol Pathol. 1987;15(4):431-8 [3432943] Annu Rev Pharmacol Toxicol. 1988;28:367-87 [3289490] Arch Biochem Biophys. 1988 Jul;264(1):253-60 [3395122] Biochem Pharmacol. 1988 Dec 15;37(24):4763-74 [3060126] J Pharmacol Exp Ther. 1989 Jan;248(1):182-9 [2464056] J Pharmacol Exp Ther. 1989 Jan;248(1):190-6 [2913271] J Pathol. 1988 Dec;156(4):275-82 [2465397] J Toxicol Environ Health. 1990;29(1):45-57 [2299686] Fundam Appl Toxicol. 1989 Nov;13(4):859-62 [2695380] Lancet. 1990 Mar 24;335(8691):732 [1969092] J Pharmacol Exp Ther. 1973 Oct;187(1):185-94 [4746326] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Circadian variation in alloxan sensitivity of mice as indicated by mortality and blood glucose alteration. AN - 72730741; 1814605 AB - The objective of this study was to determine in mice if a time-dependent pancreatic beta-cell susceptibility to alloxan could be correlated to daily changes in blood glucose levels and to monitor the pattern of blood glucose at various times of day as mice became diabetic. Food was removed from mice standardized to a 12-h light:dark cycle (lights on at 0600 h CST, during the month of June) at 12 h before subcutaneous injection with 0.27 mg/g of alloxan. Six groups of 30 fasted mice were injected at 4-h intervals. Blood glucose levels were measured from each group immediately prior to injection, and at 2, 4, 8, 12, 24, 48, and 216 h after treatment. Animals receiving alloxan during the early- to middark period had an increase in blood glucose after 2 h, followed by a decline to hypoglycemic levels between 4 and 8 h, and recovery to hyperglycemic levels 48 h after alloxan exposure. Three and 30% of these animals were dead at 8 and 48 h, respectively. Mice treated during the midlight span had decreased blood glucose levels 2 h after alloxan treatment followed by an increase to diabetic hyperglycemia within 48 h. Twenty-three and 70% of the animals treated at 1430 h were dead at 8 and 48 h, respectively. At 216 h, total mortality was 45.6% and 81 of the 98 surviving mice were hyperglycemic. These data suggest a greater sensitivity to alloxan during the midlight resting period of the mice. This may be the result of increased sensitivity to the insulin released from the beta cells when alloxan was given during the light span. JF - Chronobiology international AU - Feuers, R J AU - Mittelstaedt, R A AU - Hunter, J D AU - Saldivar, J AU - Tsai, T H AU - Scheving, L E AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 67 EP - 74 VL - 8 IS - 1 SN - 0742-0528, 0742-0528 KW - Blood Glucose KW - 0 KW - Alloxan KW - 6SW5YHA5NG KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Drug Administration Schedule KW - Death KW - Analysis of Variance KW - Mice KW - Male KW - Alloxan -- toxicity KW - Circadian Rhythm KW - Blood Glucose -- metabolism KW - Alloxan -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72730741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronobiology+international&rft.atitle=Circadian+variation+in+alloxan+sensitivity+of+mice+as+indicated+by+mortality+and+blood+glucose+alteration.&rft.au=Feuers%2C+R+J%3BMittelstaedt%2C+R+A%3BHunter%2C+J+D%3BSaldivar%2C+J%3BTsai%2C+T+H%3BScheving%2C+L+E&rft.aulast=Feuers&rft.aufirst=R&rft.date=1991-02-01&rft.volume=8&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Chronobiology+international&rft.issn=07420528&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-19 N1 - Date created - 1992-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. AN - 80359439; 1985242 AB - In both animal and epidemiologic studies, exposure to dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD) has been associated with an increased risk of cancer. We conducted a retrospective cohort study of mortality among the 5172 workers at 12 plants in the United States that produced chemicals contaminated with TCDD. Occupational exposure was documented by reviewing job descriptions and by measuring TCDD in serum from a sample of 253 workers. Causes of death were taken from death certificates. Mortality from several cancers previously associated with TCDD (stomach, liver, and nasal cancers, Hodgkin's disease, and non-Hodgkin's lymphoma) was not significantly elevated in this cohort. Mortality from soft-tissue sarcoma was increased, but not significantly (4 deaths; standardized mortality ratio [SMR], 338; 95 percent confidence interval, 92 to 865). In the subcohort of 1520 workers with greater than or equal to 1 year of exposure and greater than or equal to 20 years of latency, however, mortality was significantly increased for soft-tissue sarcoma (3 deaths; SMR, 922; 95 percent confidence interval, 190 to 2695) and for cancers of the respiratory system (SMR, 142; 95 percent confidence interval, 103 to 192). Mortality from all cancers combined was slightly but significantly elevated in the overall cohort (SMR, 115; 95 percent confidence interval, 102 to 130) and was higher in the subcohort with greater than or equal to 1 year of exposure and greater than or equal to 20 years of latency (SMR, 146; 95 percent confidence interval, 121 to 176). This study of mortality among workers with occupational exposure to TCDD does not confirm the high relative risks reported for many cancers in previous studies. Conclusions about an increase in the risk of soft-tissue sarcoma are limited by small numbers and misclassification on death certificates. Excess mortality from all cancers combined, cancers of the respiratory tract, and soft-tissue sarcoma may result from exposure to TCDD, although we cannot exclude the possible contribution of factors such as smoking and occupational exposure to other chemicals. JF - The New England journal of medicine AU - Fingerhut, M A AU - Halperin, W E AU - Marlow, D A AU - Piacitelli, L A AU - Honchar, P A AU - Sweeney, M H AU - Greife, A L AU - Dill, P A AU - Steenland, K AU - Suruda, A J AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Cincinnati, OH 45226. Y1 - 1991/01/24/ PY - 1991 DA - 1991 Jan 24 SP - 212 EP - 218 VL - 324 IS - 4 SN - 0028-4793, 0028-4793 KW - Polychlorinated Dibenzodioxins KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Tracheal Neoplasms -- mortality KW - Risk KW - Life Tables KW - Soft Tissue Neoplasms -- mortality KW - Sarcoma -- mortality KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Bronchial Neoplasms -- mortality KW - United States -- epidemiology KW - Male KW - Chemical Industry KW - Occupational Exposure KW - Neoplasms -- mortality KW - Polychlorinated Dibenzodioxins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80359439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Cancer+mortality+in+workers+exposed+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Fingerhut%2C+M+A%3BHalperin%2C+W+E%3BMarlow%2C+D+A%3BPiacitelli%2C+L+A%3BHonchar%2C+P+A%3BSweeney%2C+M+H%3BGreife%2C+A+L%3BDill%2C+P+A%3BSteenland%2C+K%3BSuruda%2C+A+J&rft.aulast=Fingerhut&rft.aufirst=M&rft.date=1991-01-24&rft.volume=324&rft.issue=4&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-07 N1 - Date created - 1991-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Jun 20;324(25):1809-12 [2038371] N Engl J Med. 1991 Jan 24;324(4):260-2 [1823116] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium-dependent eicosanoid metabolism by concanavalin A-stimulated human monocytes in vitro. Synergism with phorbol ester indicates separate regulation of leukotriene B4 synthesis and release. AN - 80421982; 1846160 AB - Human monocytes obtained by counter-current centrifugal elutriation released arachidonic acid when challenged in vitro with Con A, as well as with other soluble (PMA or ionomycin) or particulate stimuli (serum-treated zymosan). Cyclo-oxygenase metabolites were the principal eicosanoids detected in the supernatants of Con A-stimulated, [3H]arachidonate-labeled monocytes, 5-Lipoxygenase (5-LO) products, such as leukotriene B4 (LTB4), were conspicuously absent. Release of arachidonate and its metabolites in response to Con A was dependent on the presence of extracellular Ca2+, but not Mg2+. In contrast to serum-treated zymosan challenge, which resulted in increased inositol trisphosphate and LTB4 release, Con A-induced inositol phospholipid hydrolysis in monocytes was limited to phosphatidylinositol or phosphatidylinositol monophosphate. Despite an inability to augment LTB4 release, Con A or PMA induced a loss of 5-lipoxygenase from a cytosolic compartment that was similar to that achieved with a calcium ionophore (ionomycin), a potent stimulus for LTB4 generation. When cell-associated LTB4 was evaluated, evidence for increased LTB4 production was obtained in response to either stimulus (PMA greater than Con A). In combination, however, PMA and Con A treatment resulted in monocyte LTB4 release comparable with that observed with the calcium ionophore or STZ. LTB4 release in response to all stimuli tested was inhibited by MK-886, a drug that binds to 5-lipoxygenase-activating protein. These results indicate the following: 1) Phospholipase A2 activation and attendant arachidonic acid release induced by agents that increase intracellular Ca2+ and/or generate diacylglycerol results in increased synthesis and release of PG and increased synthesis of leukotrienes, but not necessarily leukotriene release. 2) 5-LO translocation, which may occur independently of increased intracellular Ca2+, may be necessary for LTB4 generation but is insufficient for its release. 3) 5-Lipoxygenase-activating protein activity is necessary for 5-LO activation and LTB4 release in response to all stimuli investigated here. 4) Phorbol ester, an activator of protein kinase C, may synergize with agents such as Con A (which by themselves induce a minimal intracellular Ca2+ rise), so as to result in the release of LTB4. Thus, Con A may represent a class of surface receptor-aggregating agents that initiates inflammatory changes or immunomodulation associated with liberation of PG and might predispose to release of other inflammatory mediators, such as leukotrienes, in the presence of additional signals including protein kinase activation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Hoffman, T AU - Brando, C AU - Lizzio, E F AU - Lee, Y L AU - Hansen, M AU - Tripathi, A K AU - Taplits, M AU - Puri, J AU - Bonvini, E AU - Abrahamsen, T G AD - Division of Hematology, United States Food and Drug Administration, Bethesda, MD 20892. Y1 - 1991/01/15/ PY - 1991 DA - 1991 Jan 15 SP - 692 EP - 700 VL - 146 IS - 2 SN - 0022-1767, 0022-1767 KW - Arachidonic Acids KW - 0 KW - Eicosanoids KW - Indoles KW - Leukotriene Antagonists KW - Phosphatidylinositols KW - MK-886 KW - 080626SQ8C KW - Concanavalin A KW - 11028-71-0 KW - Leukotriene B4 KW - 1HGW4DR56D KW - Arachidonic Acid KW - 27YG812J1I KW - Arachidonate 5-Lipoxygenase KW - EC 1.13.11.34 KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Phosphatidylinositols -- metabolism KW - Enzyme Activation KW - Humans KW - Biological Transport KW - Arachidonic Acids -- metabolism KW - Arachidonate 5-Lipoxygenase -- metabolism KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Indoles -- pharmacology KW - Phospholipases A -- metabolism KW - Leukotriene B4 -- metabolism KW - Eicosanoids -- metabolism KW - Monocytes -- metabolism KW - Calcium -- physiology KW - Monocytes -- drug effects KW - Concanavalin A -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80421982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Calcium-dependent+eicosanoid+metabolism+by+concanavalin+A-stimulated+human+monocytes+in+vitro.+Synergism+with+phorbol+ester+indicates+separate+regulation+of+leukotriene+B4+synthesis+and+release.&rft.au=Hoffman%2C+T%3BBrando%2C+C%3BLizzio%2C+E+F%3BLee%2C+Y+L%3BHansen%2C+M%3BTripathi%2C+A+K%3BTaplits%2C+M%3BPuri%2C+J%3BBonvini%2C+E%3BAbrahamsen%2C+T+G&rft.aulast=Hoffman&rft.aufirst=T&rft.date=1991-01-15&rft.volume=146&rft.issue=2&rft.spage=692&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-19 N1 - Date created - 1991-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules AN - 19797245; 8740371 AB - We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis. Images JF - Nucleic Acids Research AU - Graessmann, M AU - Michaels, G AU - Berg, B AU - Graessmann, A AD - Department of Health and Human Services, National Institute of Health, Bethesda, MA 20892, USA Y1 - 1991/01/11/ PY - 1991 DA - 1991 Jan 11 SP - 53 EP - 59 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 19 IS - 1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gene expression KW - Antisense RNA KW - Simian virus 40 KW - DNA KW - Microinjection KW - W 30940:Products KW - V 22340:Antiviral Agents KW - N 14830:RNA KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19797245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Inhibition+of+SV40+gene+expression+by+microinjected+small+antisense+RNA+and+DNA+molecules&rft.au=Graessmann%2C+M%3BMichaels%2C+G%3BBerg%2C+B%3BGraessmann%2C+A&rft.aulast=Graessmann&rft.aufirst=M&rft.date=1991-01-11&rft.volume=19&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Antisense RNA; DNA; Microinjection; Simian virus 40 ER - TY - JOUR T1 - National objectives for reducing violent and abusive behavior AN - 839254069; 1079901 JF - Response to the victimization of women and children Y1 - 1991 PY - 1991 DA - 1991 SP - 21 VL - 14 IS - 1(78) SN - 0894-7597, 0894-7597 KW - Sociology KW - Domestic violence KW - Violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839254069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Response+to+the+victimization+of+women+and+children&rft.atitle=National+objectives+for+reducing+violent+and+abusive+behavior&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=14&rft.issue=1%2878%29&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Response+to+the+victimization+of+women+and+children&rft.issn=08947597&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13325; 3708 13325 ER - TY - JOUR T1 - Vacuuming a mercury-contaminated dental office may be hazardous to your health. AN - 80713883; 1860523 AB - Exposure to mercury contamination in the dental office poses a potential hazard for dental personnel. Although many precautions for containing the poisonous metal vapors are routinely observed, dental personnel may place themselves at risk by failing to use proper cleaning techniques. Researchers from the National Institute for Occupational Safety and Health (NIOSH) have discovered that vacuum cleaners designed for the home are sometimes used to clean dental office carpets, which might be contaminated with mercury. Since ordinary vacuum cleaners increase airborne mercury concentrations, dental personnel should use a specially designed vacuuming system for mercury recovery. JF - The Dental assistant AU - Votaw, A L AU - Zey, J AD - HETAB, NIOSH, R-9, Cincinnati, OH. PY - 1991 SP - 27 EP - 29 VL - 60 IS - 1 SN - 0011-8508, 0011-8508 KW - Mercury KW - FXS1BY2PGL KW - Dentistry KW - United States KW - Occupational Exposure KW - Dental Offices KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Mercury -- adverse effects KW - Housekeeping -- methods KW - Mercury -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80713883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Dental+assistant&rft.atitle=Vacuuming+a+mercury-contaminated+dental+office+may+be+hazardous+to+your+health.&rft.au=Votaw%2C+A+L%3BZey%2C+J&rft.aulast=Votaw&rft.aufirst=A&rft.date=1991-01-01&rft.volume=60&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=The+Dental+assistant&rft.issn=00118508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-04 N1 - Date created - 1991-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A study of the prevalence of acute respiratory disorders among workers in the textile industry. AN - 80699800; 1856010 AB - An epidemiological study of 774 workers in seven eastern France cotton textile factories was conducted to determine the prevalence of acute respiratory disorders. From nine non-textile companies, 464 workers, stratified as to sex, age and tobacco consumption participated in the study as a control population. A questionnaire designed to elicit the respiratory symptoms (in particular the Monday tightness characterizing byssinosis) was administered to the 1238 workers. Peak-expiratory-flow (PEF) measurement was made for each subject, exposed and non-exposed, before the start of the shift on the day of the worker's return to work and repeated at the end of the shift. The PEF's variations during the workshift were studied. Present Monday tightness was mentioned by 48 cotton exposed workers (6.2%) and by 9 non-exposed (1.9%) (P less than 0.001). A 10% decrease in PEF during the shift was present in 63 cotton exposed workers (8.1%) and in 10 non-exposed (2.1%) (P less than 0.001). For the exposed population, Monday tightness was analysed using multiple logistic regression, showing an absence of a link with smoking, an increased occurrence after 20 years of exposure (OR = 7.3) and a link with current job (more frequent among those with the dustiest jobs) (OR = 4.9). The multiple logistic analysis of a 10% decrease in PEF showed effects of smoking habits (OR = 1.86). It also showed a link with "highly polluted job" history (OR = 2.7), but especially with present job (OR = 3.4). The absence of a constant link between Monday tightness and drop of the PEF was found. JF - International archives of occupational and environmental health AU - Massin, N AU - Moulin, J J AU - Wild, P AU - Meyer-Bisch, C AU - Mur, J M AD - INRS (French National Institute for Occupational Safety and Health), Vandoeuvre Les Nancy, France. Y1 - 1991 PY - 1991 DA - 1991 SP - 555 EP - 560 VL - 62 IS - 8 SN - 0340-0131, 0340-0131 KW - Index Medicus KW - Peak Expiratory Flow Rate KW - Humans KW - Adult KW - Surveys and Questionnaires KW - France -- epidemiology KW - Aged KW - Middle Aged KW - Male KW - Gossypium KW - Female KW - Prevalence KW - Multivariate Analysis KW - Byssinosis -- epidemiology KW - Byssinosis -- physiopathology KW - Textile Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80699800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+archives+of+occupational+and+environmental+health&rft.atitle=A+study+of+the+prevalence+of+acute+respiratory+disorders+among+workers+in+the+textile+industry.&rft.au=Massin%2C+N%3BMoulin%2C+J+J%3BWild%2C+P%3BMeyer-Bisch%2C+C%3BMur%2C+J+M&rft.aulast=Massin&rft.aufirst=N&rft.date=1991-01-01&rft.volume=62&rft.issue=8&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=International+archives+of+occupational+and+environmental+health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-29 N1 - Date created - 1991-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Proto-oncogene activation in rodent and human tumors. AN - 80675293; 2068988 AB - The transformation of a normal cell into a tumorigenic cell involves both the activation and concerted expression of proto-oncogenes and inactivation of suppressor genes. The activation of ras proto-oncogenes represents one step in the multistep process of carcinogenesis for a variety of rodent and human tumors. This activation is probably an early event in tumorigenesis in many cases and may be the 'initiation' event in some cases. Thus, a chemical that induces rodent tumors by activation of ras proto-oncogenes can potentially invoke one step of the neoplastic process in humans exposed to the chemical. Moreover, dominant transforming oncogenes other than ras have been detected in human tumors as well as rodent tumors. The involvement of these putative proto-oncogenes in the development of neoplasia is unclear at present. JF - Advances in experimental medicine and biology AU - Anderson, M W AU - You, M AU - Reynolds, S H AD - Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709. Y1 - 1991 PY - 1991 DA - 1991 SP - 235 EP - 243 VL - 283 SN - 0065-2598, 0065-2598 KW - Index Medicus KW - Animals KW - Humans KW - Lung Neoplasms -- genetics KW - Mice KW - Gene Expression Regulation KW - Mutation KW - Proto-Oncogenes KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80675293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Proto-oncogene+activation+in+rodent+and+human+tumors.&rft.au=Anderson%2C+M+W%3BYou%2C+M%3BReynolds%2C+S+H&rft.aulast=Anderson&rft.aufirst=M&rft.date=1991-01-01&rft.volume=283&rft.issue=&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-14 N1 - Date created - 1991-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of stemphyltoxin III, a metabolite of Alternaria alternata. AN - 80579262; 2036005 AB - Some common decay organisms of vegetables and ripened fruits are Alternaria species. Even fruits and vegetables kept under refrigeration can be spoiled by Alternaria species because the mold grows at low temperatures. Alternaria alternata is commonly found in grain in areas with a high incidence of esophageal cancer. Three metabolites, altertoxins I, II, and III, have been isolated from A. alternata and have hydroxyperylenequinone structures. Although other perylenequinone metabolites such as stemphyperylenol and stemphyltoxins I, II, III, and IV, have been isolated from Stemphylium botryosum var. lactucum, a plant pathogen and mold, we isolated and identified stemphyltoxin III from A. alternata. This metabolite was tested for mutagenicity in the Ames Salmonella typhimurium plate incorporation assay with and without Aroclor 1254-induced rat S-9 metabolic activation. A positive response was noted with and without metabolic activation in S. typhimurium TA98 and TA1537, and there was a marginal response in strain TA100. JF - Applied and environmental microbiology AU - Davis, V M AU - Stack, M E AD - Division of Toxicological Studies, Food and Drug Administration, Washington, D.C 20204. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 180 EP - 182 VL - 57 IS - 1 SN - 0099-2240, 0099-2240 KW - Mutagens KW - 0 KW - stemphyltoxin III KW - 102694-32-6 KW - Perylene KW - 5QD5427UN7 KW - Index Medicus KW - Mutagenicity Tests KW - Food Microbiology KW - Food Contamination KW - Perylene -- pharmacology KW - Perylene -- analogs & derivatives KW - Alternaria -- metabolism KW - Perylene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80579262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Mutagenicity+of+stemphyltoxin+III%2C+a+metabolite+of+Alternaria+alternata.&rft.au=Davis%2C+V+M%3BStack%2C+M+E&rft.aulast=Davis&rft.aufirst=V&rft.date=1991-01-01&rft.volume=57&rft.issue=1&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-24 N1 - Date created - 1991-06-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Experientia. 1984 Nov 15;40(11):1248-50 [6548712] Appl Environ Microbiol. 1986 Oct;52(4):718-22 [3535674] Mutat Res. 1975 Dec;31(6):347-64 [768755] J Nat Prod. 1989 Mar-Apr;52(2):426-7 [2746264] Carcinogenesis. 1987 Jul;8(7):989-91 [3594731] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of elemental mercury exposure at a thermometer plant. AN - 80573713; 2035548 AB - This study compares 84 mercury-exposed workers at a thermometer manufacturing facility with 79 unexposed workers for evidence of chronic mercury toxicity. Personal breathing-zone air concentrations of mercury ranged from 25.6 to 270.6 micrograms/m3 for thermometer workers. Urinary mercury levels in the study population ranged from 1.3 to 344.5 micrograms/g creatinine, with eight (10%) participants exceeding 150 micrograms/g creatinine and three workers exceeding 300 micrograms/g creatinine, which indicates increased absorption of mercury among the thermometer workers. All urine mercury levels in the comparison group were compatible with normal background levels in unexposed adults (less than 10 micrograms/g creatinine). Thermometer plant workers reported more symptoms than did controls; in general, these differences were not statistically significant and could not be specifically associated with mercury exposure. Static tremor, abnormal Romberg test, dysdiadochokinesia, and difficulty with heel-to-toe gait were more prevalent among thermometer workers than control workers, which could not be associated with recent mercury exposure; there was some suggestion of an association with chronic exposure. There were no intergroup differences for the standard clinical tests of renal function except for a significantly higher mean specific gravity among the thermometer workers. A positive correlation was found, however, between urinary N-acetyl-b-D-glucosaminidase (NAG) and urinary mercury. There was no consistent evidence for intergroup differences in proximal renal tubule function, as measured by urinary beta 2-microglobulin (B2M) or retinol binding protein (RBP). JF - American journal of industrial medicine AU - Ehrenberg, R L AU - Vogt, R L AU - Smith, A B AU - Brondum, J AU - Brightwell, W S AU - Hudson, P J AU - McManus, K P AU - Hannon, W H AU - Phipps, F C AD - National Institute for Occupational Safety and Health, CDC, Atlanta, GA 30333. Y1 - 1991 PY - 1991 DA - 1991 SP - 495 EP - 507 VL - 19 IS - 4 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Biomarkers KW - Retinol-Binding Proteins KW - beta 2-Microglobulin KW - Creatinine KW - AYI8EX34EU KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Retinol-Binding Proteins -- urine KW - Creatinine -- urine KW - Mercury -- urine KW - Humans KW - Biomarkers -- urine KW - beta 2-Microglobulin -- urine KW - Albuminuria -- chemically induced KW - Nervous System Diseases -- chemically induced KW - Occupational Diseases -- chemically induced KW - Environmental Monitoring KW - Nervous System Diseases -- epidemiology KW - Adult KW - Occupational Diseases -- epidemiology KW - Epidemiological Monitoring KW - Middle Aged KW - Female KW - Male KW - Proteinuria -- chemically induced KW - Prevalence KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Mercury Poisoning -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80573713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Effects+of+elemental+mercury+exposure+at+a+thermometer+plant.&rft.au=Ehrenberg%2C+R+L%3BVogt%2C+R+L%3BSmith%2C+A+B%3BBrondum%2C+J%3BBrightwell%2C+W+S%3BHudson%2C+P+J%3BMcManus%2C+K+P%3BHannon%2C+W+H%3BPhipps%2C+F+C&rft.aulast=Ehrenberg&rft.aufirst=R&rft.date=1991-01-01&rft.volume=19&rft.issue=4&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-21 N1 - Date created - 1991-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Does good peer review assure good epidemiology? AN - 80554910; 2030384 AB - The American public requires that research projects use resources efficiently, that they provide answers that are beneficial, and that they are carried out ethically. Peer review of research protocols, results, and reports, provides one way to improve research and to reassure the public. JF - Journal of clinical epidemiology AU - Andrews, J S AD - Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, Georgia. Y1 - 1991 PY - 1991 DA - 1991 SP - 131S EP - 134S VL - 44 Suppl 1 SN - 0895-4356, 0895-4356 KW - Bioethics KW - Index Medicus KW - Biomedical and Behavioral Research KW - Bioethics and Professional Ethics KW - Ethics, Medical KW - Research KW - Epidemiology -- standards KW - Peer Review -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80554910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Does+good+peer+review+assure+good+epidemiology%3F&rft.au=Andrews%2C+J+S&rft.aulast=Andrews&rft.aufirst=J&rft.date=1991-01-01&rft.volume=44+Suppl+1&rft.issue=&rft.spage=131S&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-20 N1 - Date created - 1991-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunoaffinity column coupled with solution fluorometry or liquid chromatography postcolumn derivatization for determination of aflatoxins in corn, peanuts, and peanut butter: collaborative study. AN - 80550777; 2026580 AB - An AOAC/IUPAC (International Union of Pure and Applied Chemistry) collaborative study was conducted to evaluate the effectiveness of an immunoaffinity column for the determination of aflatoxin. The test portion is extracted with methanol-water (7 + 3), filtered, diluted to less than 30% methanol with water, and applied to the affinity column. The column is washed with water and the concentrated aflatoxins are eluted with methanol. Total aflatoxins are determined by solution fluorometry with bromine (SFB), and individual toxins are determined by reverse-phase liquid chromatography with postcolumn derivatization with iodine (PCD). Corn naturally contaminated with aflatoxins, and peanuts, peanut butter, and corn containing added aflatoxins (B1:B2:G1:G2 = 7:1:3:1) were sent to 24 collaborators in the United States, France, Canada, and the Republic of South Africa. Twelve collaborators used the SFB method, 9 used the PCD method, and 3 used both SFB and PCD methods. Twenty collaborators completed the study (10 used the SFB method, 7 used the PCD method, and 3 used both SFB and PCD methods). Test portions were spiked at 10, 20, and 30 ng/g. For SFB analyses, recoveries of total aflatoxins were 123, 105, and 107%, respectively; the relative standard deviation for repeatability (RSDr) ranged from 11.75 to 16.57%, and the relative standard deviation for reproducibility (RSDR) ranged from 10.97 to 33.09%. For PCD analyses, recoveries were 81, 81, and 83%, respectively; the RSDr ranged from 5.20 to 17.22%, and the RSDR ranged from 4.68 to 50.77%. The RSDr for aflatoxins B1 and G1 for spiked test portions ranged from 5.45 to 23.55%, and the RSDR ranged from 4.21 to 57.28%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal - Association of Official Analytical Chemists AU - Trucksess, M W AU - Stack, M E AU - Nesheim, S AU - Page, S W AU - Albert, R H AU - Hansen, T J AU - Donahue, K F AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 81 EP - 88 VL - 74 IS - 1 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Index Medicus KW - Chromatography, Affinity KW - Spectrometry, Fluorescence KW - Chromatography, Liquid KW - Aflatoxins -- analysis KW - Arachis -- analysis KW - Zea mays -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80550777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Immunoaffinity+column+coupled+with+solution+fluorometry+or+liquid+chromatography+postcolumn+derivatization+for+determination+of+aflatoxins+in+corn%2C+peanuts%2C+and+peanut+butter%3A+collaborative+study.&rft.au=Trucksess%2C+M+W%3BStack%2C+M+E%3BNesheim%2C+S%3BPage%2C+S+W%3BAlbert%2C+R+H%3BHansen%2C+T+J%3BDonahue%2C+K+F&rft.aulast=Trucksess&rft.aufirst=M&rft.date=1991-01-01&rft.volume=74&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Scientific and regulatory considerations in the development of human growth factors. AN - 80550649; 1367138 JF - Bioprocess technology AU - Fleming, G A AU - Jordan, A W AU - Chiu, Y Y AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1991 PY - 1991 DA - 1991 SP - 341 EP - 354 VL - 13 SN - 0888-7470, 0888-7470 KW - Growth Hormone KW - 9002-72-6 KW - Biotechnology KW - Animals KW - Humans KW - Growth Hormone -- standards KW - Legislation, Drug KW - Growth Hormone -- pharmacology KW - Growth Hormone -- chemistry KW - Growth Hormone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80550649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioprocess+technology&rft.atitle=Scientific+and+regulatory+considerations+in+the+development+of+human+growth+factors.&rft.au=Fleming%2C+G+A%3BJordan%2C+A+W%3BChiu%2C+Y+Y&rft.aulast=Fleming&rft.aufirst=G&rft.date=1991-01-01&rft.volume=13&rft.issue=&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Bioprocess+technology&rft.issn=08887470&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-19 N1 - Date created - 1991-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. AN - 80536772; 2022192 AB - We have developed a limiting dilution clonal assay for determining the frequency of 6-thioguanine-resistant (TGr) lymphocytes produced in rats by in vivo exposure to genotoxic agents. Spleen lymphocytes were isolated from female Fischer 344 rats and were cultured with 1 microgram/ml of phytohemagglutinin (PHA) for 40 hr. Northern blot analysis revealed that this procedure resulted in increased hprt and beta-actin mRNA synthesis. Conditions for optimum cloning were established by culturing four PHA-primed lymphocytes/well in 96-well round-bottom microtiter plates containing a medium supplemented with interleukin-2. These cultures also contained autologous and/or TK6 feeder cells inactivated with different doses of irradiation. Lymphocyte cloning efficiencies (CEs) were highest in plates containing both irradiated TK6 cells (5 x 10(3) cells/well; 90 Gy) and irradiated autologous feeder cells (5 x 10(4) cells/well; 50 Gy). CE did not depend on the number of primed lymphocytes/well when four or fewer target cells/well were cloned. To measure the effects of chemical mutagens on the frequency of TGr lymphocytes, rats were given a single i.p. injection of 0-150 mg/kg of N-ethyl-N-nitrosourea (ENU), a direct-acting alkylating agent, or 0-50 mg/kg of cyclophosphamide (CP), an indirect acting alkylating agent. Lymphocytes were isolated, primed, and cloned at 4 weeks after CP treatment and at 1, 2, 4 and 6 weeks after ENU treatment. CE in these cultures ranged from 12% to 27%. Cultures were also established for measuring CE in the presence of 6-thioguanine (TG) and these contained 5 x 10(3) irradiated TK6 cells and 5 x 10(4) primed rat lymphocytes/well. The frequency of TGr lymphocytes was calculated by correcting the CE in the presence of TG with the CE measured in its absence. ENU exposure produced a higher frequency of TGr lymphocytes than CP, but both chemicals produced a dose-dependent increase in TGr cells. In addition, the frequency of ENU-induced TGr lymphocytes increased with time after treatment. The TGr cells are presumed to be hprt mutants, but further analysis at the DNA level is required to establish this. The dose-dependent responses obtained with both ENU and CP treatments suggest that rat lymphocytes are sensitive to direct- and indirect-acting alkylating agents administered in vivo and that the rat lymphocyte assay is a useful complement to the in vivo/in vitro mouse assay for determining the mutagenicity of environmental toxicants. JF - Environmental and molecular mutagenesis AU - Aidoo, A AU - Lyn-Cook, L E AU - Mittelstaedt, R A AU - Heflich, R H AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, Arkansas. Y1 - 1991 PY - 1991 DA - 1991 SP - 141 EP - 151 VL - 17 IS - 3 SN - 0893-6692, 0893-6692 KW - Actins KW - 0 KW - RNA, Messenger KW - Cyclophosphamide KW - 8N3DW7272P KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Thioguanine KW - FTK8U1GZNX KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Rats KW - Clone Cells KW - Animals KW - Rats, Inbred F344 KW - Blotting, Northern KW - Actins -- genetics KW - RNA, Messenger -- metabolism KW - Hypoxanthine Phosphoribosyltransferase -- metabolism KW - Drug Resistance KW - Female KW - Ethylnitrosourea -- toxicity KW - Mutagenicity Tests -- methods KW - Lymphocytes -- metabolism KW - Cyclophosphamide -- toxicity KW - Lymphocytes -- drug effects KW - Thioguanine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80536772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Induction+of+6-thioguanine-resistant+lymphocytes+in+Fischer+344+rats+following+in+vivo+exposure+to+N-ethyl-N-nitrosourea+and+cyclophosphamide.&rft.au=Aidoo%2C+A%3BLyn-Cook%2C+L+E%3BMittelstaedt%2C+R+A%3BHeflich%2C+R+H%3BCasciano%2C+D+A&rft.aulast=Aidoo&rft.aufirst=A&rft.date=1991-01-01&rft.volume=17&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-31 N1 - Date created - 1991-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nitro group orientation, reduction potential, and direct-acting mutagenicity of nitro-polycyclic aromatic hydrocarbons. AN - 80533929; 2022194 AB - Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are widespread genotoxic environmental pollutants. We have been interested in determining the structural and electronic features that may be useful in predicting the direct-acting mutagenic activity of nitro-PAHs in Salmonella typhimurium. In this study, a series of structurally related nitro-PAHs were used to determine the relationships among direct-acting mutagenicity, orientation of the nitro group, and reduction potential of the nitro group. The compounds consisted of isomeric mononitrated and dinitrated benzo[e]pyrenes, their derivatives, and other nitro-PAHs ranging from two to five aromatic-ring molecules in size. A general finding is that nitro-PAHs with their nitro substituent oriented perpendicular to the aromatic system exhibit either very weak or no direct-acting mutagenicity in S. typhimurium strains TA98 and TA100. However, if a nitro-PAH of this type has a relatively low first half-wave reduction potential, it may be direct-acting. Furthermore, a positive correlation between the first half-wave reduction potential and direct-acting mutagenicity is found only when the compounds are structurally similar. Consequently, the correlation cannot be made using nitro-PAHs with different molecular size. Nitro-PAHs having a perpendicular nitro orientation always have a higher (absolute value) first half-wave reduction potential than the isomer(s) with a parallel orientation. Perhaps due to electron-withdrawing by the second nitro group, dinitro-PAHs always have a lower first half-wave reduction potential than their mononitro analogues. These findings provide a useful molecular basis for interpreting and predicting the direct-acting mutagenicity of nitro-PAHs. JF - Environmental and molecular mutagenesis AU - Jung, H AU - Shaikh, A U AU - Heflich, R H AU - Fu, P P AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 169 EP - 180 VL - 17 IS - 3 SN - 0893-6692, 0893-6692 KW - Mutagens KW - 0 KW - Nitro Compounds KW - Polycyclic Compounds KW - 6-nitrosobenzo(a)pyrene KW - 118745-15-6 KW - 3-nitroso-7,8,9,10-tetrahydrobenzo(a)pyrene KW - 134998-76-8 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Oxidation-Reduction KW - Mutagenicity Tests KW - Polarography KW - Benzo(a)pyrene -- toxicity KW - Salmonella typhimurium -- drug effects KW - Electrochemistry KW - Structure-Activity Relationship KW - Nitro Compounds -- toxicity KW - Nitro Compounds -- chemistry KW - Polycyclic Compounds -- toxicity KW - Mutagens -- chemistry KW - Polycyclic Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80533929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Nitro+group+orientation%2C+reduction+potential%2C+and+direct-acting+mutagenicity+of+nitro-polycyclic+aromatic+hydrocarbons.&rft.au=Jung%2C+H%3BShaikh%2C+A+U%3BHeflich%2C+R+H%3BFu%2C+P+P&rft.aulast=Jung&rft.aufirst=H&rft.date=1991-01-01&rft.volume=17&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-31 N1 - Date created - 1991-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 4,4'-Methylenebis(2-chloroaniline) (MOCA): the effect of multiple oral administration, route, and phenobarbital induction on macromolecular adduct formation in the rat. AN - 80532780; 2019352 AB - The effect of multiple oral administration of MOCA, a suspect human carcinogen, was studied in the adult male rat. As many as 28 consecutive daily doses of [14C]MOCA at 28.1 mumol/kg body wt (5 microCi/day) were administered and rats were euthanized at weekly intervals for 7 weeks. MOCA adduct formation for globin and serum albumin was evaluated by determination of [14C]MOCA covalent binding. The covalent binding associated with globin showed a linear increase over the 28-day exposure period with 342 fmol/mg globin 24 hr after the final dose. More extensive covalent binding was detected for albumin with 443 fmol/mg albumin after the final dose, but increases were not linear. After cessation of dosing, the albumin adduct levels decreased rapidly (t1/2 = 4.6 days) in relation to globin adduct levels (t1/2 = 16.1 days). The MOCA-globin adduct t1/2 is consistent with that determined after a single 281 mumol/kg oral dose of MOCA. Significant differences related to route of administration were detected for 24-hr globin covalent binding with ip greater than po greater than dermal. Distribution of undifferentiated [14C]MOCA was highest in the liver at 24 hr with tissue levels for liver greater than kidney greater than lung greater than spleen greater than testes greater than urinary bladder. Induction of cytochrome P450 enzymes by administration of phenobarbital (100 mg/kg/day/3 days) resulted in a significant (p less than 0.05) increase in MOCA-globin adduct formation detected with 33.5 pmol/mg globin for induced rats versus 13.6 pmol/mg globin for control rats. Although MOCA-globin and albumin adducts show differing stability, quantification of such MOCA adducts may be useful for long-term industrial biomonitoring of MOCA. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Cheever, K L AU - DeBord, D G AU - Swearengin, T F AD - Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 71 EP - 80 VL - 16 IS - 1 SN - 0272-0590, 0272-0590 KW - Serum Albumin KW - 0 KW - Methylenebis(chloroaniline) KW - 3L2W5VTT2A KW - Globins KW - 9004-22-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Administration, Oral KW - Serum Albumin -- metabolism KW - Animals KW - Globins -- isolation & purification KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Tissue Distribution KW - Chromatography, High Pressure Liquid KW - Rats KW - Rats, Inbred Strains KW - Risk KW - Half-Life KW - Chromatography, Thin Layer KW - Globins -- metabolism KW - Male KW - Phenobarbital -- pharmacology KW - Enzyme Induction -- drug effects KW - Methylenebis(chloroaniline) -- toxicity KW - Methylenebis(chloroaniline) -- pharmacokinetics KW - Methylenebis(chloroaniline) -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80532780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=4%2C4%27-Methylenebis%282-chloroaniline%29+%28MOCA%29%3A+the+effect+of+multiple+oral+administration%2C+route%2C+and+phenobarbital+induction+on+macromolecular+adduct+formation+in+the+rat.&rft.au=Cheever%2C+K+L%3BDeBord%2C+D+G%3BSwearengin%2C+T+F&rft.aulast=Cheever&rft.aufirst=K&rft.date=1991-01-01&rft.volume=16&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet. AN - 80529821; 2019351 AB - Diet is a major influence on the responses of experimental animals to drugs, toxins, and carcinogens. Two diets used widely in toxicological and carcinogenic studies, and considered to be nutritionally adequate, were compared with respect to neoplastic responses to 2-acetylaminofluorene (2-AAF). Both sexes of weanling B6C3F1 mice were fed either AIN-76A (a purified diet) or NIH-07 (a natural ingredient diet), with or without 2-AAF, for up to 2 years. Dosages of 2-AAF were administered to males at 0, 40, 60, or 80 ppm in each diet and to females at 0, 150, 200, or 250 ppm. Each group consisted of 96 mice, except the groups of females dosed at 0 and 150 ppm, which consisted of 120 and 72 mice, respectively. The incidence of malignant liver tumors was significantly greater in all AIN-fed groups compared to corresponding NIH-fed groups, as was the total incidence of tumors (malignant + benign). Similarly, the incidence of malignant and total bladder tumors was greater in AIN-fed groups of mice administered the two high doses of 2-AAF for each sex compared to NIH-fed groups. No malignant bladder tumors were observed among any of the groups of mice receiving control diets. This was also true for the males on low dosages (40 ppm) of 2-AAF. The AIN-fed group of low dose females (150 ppm) developed 4% incidence of malignant bladder tumors. This study dramatically showed the importance of diet selection in chronic carcinogenic studies and suggests that results obtained with the use of a purified diet may differ both qualitatively and quantitatively from results obtained with a natural ingredient diet. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Fullerton, F R AU - Greenman, D L AU - McCarty, C C AU - Bucci, T J AD - National Center for Toxicological Research, Jefferson, Arkansas 72029. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 51 EP - 60 VL - 16 IS - 1 SN - 0272-0590, 0272-0590 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Body Weight -- drug effects KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Energy Intake KW - Mice KW - Male KW - Growth -- drug effects KW - Female KW - Urinary Bladder Neoplasms -- physiopathology KW - 2-Acetylaminofluorene -- toxicity KW - Liver Neoplasms, Experimental -- physiopathology KW - Liver Neoplasms, Experimental -- chemically induced KW - Diet KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80529821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Increased+incidence+of+spontaneous+and+2-acetylaminofluorene-induced+liver+and+bladder+tumors+in+B6C3F1+mice+fed+AIN-76A+diet+versus+NIH-07+diet.&rft.au=Fullerton%2C+F+R%3BGreenman%2C+D+L%3BMcCarty%2C+C+C%3BBucci%2C+T+J&rft.aulast=Fullerton&rft.aufirst=F&rft.date=1991-01-01&rft.volume=16&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of foodborne pathogens by nucleic acid hybridization. AN - 80524432; 2018707 AB - Nucleic acid hybridization methods have been developed and used to identify microorganisms in foods. Tests performed on mixed cultures save the time required to establish pure cultures. Enterotoxigenic or invasive strains of foodborne bacterial pathogens are detected with probes that identify genes responsible for virulence. Hybridization tests signal the presence or absence of a particular strain or an entire genus and are especially well suited for screening foods for specific pathogens. With the colony hybridization assay format, foodborne bacteria harboring a specific gene can be enumerated. However, hybridization tests require the presence of 10(5) to 10(6) cells to yield a positive result, thereby limiting sensitivity and necessitating a time-consuming growth step. In vitro DNA amplification techniques increase the amount of DNA segments 10(5)-10(6)-fold in 2 to 3 h, thus enhancing test sensitivity. JF - International journal of food microbiology AU - Hill, W E AU - Keasler, S P AD - Molecular Biology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 67 EP - 75 VL - 12 IS - 1 SN - 0168-1605, 0168-1605 KW - DNA Probes KW - 0 KW - RNA Probes KW - Index Medicus KW - Polymerase Chain Reaction KW - Bacterial Infections -- prevention & control KW - Virulence -- genetics KW - Nucleic Acid Hybridization KW - Bacterial Typing Techniques KW - Bacteria -- genetics KW - Food Microbiology KW - Viruses -- isolation & purification KW - Bacteria -- pathogenicity KW - Bacteria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80524432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Identification+of+foodborne+pathogens+by+nucleic+acid+hybridization.&rft.au=Hill%2C+W+E%3BKeasler%2C+S+P&rft.aulast=Hill&rft.aufirst=W&rft.date=1991-01-01&rft.volume=12&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Consequences of the nuclear power plant accident at Chernobyl. AN - 80454530; 1899937 AB - The Chernobyl Nuclear Power Plant accident, in the Ukrainian Soviet Socialist Republic (SSR), on April 26, 1986, was the first major nuclear power plant accident that resulted in a large-scale fire and subsequent explosions, immediate and delayed deaths of plant operators and emergency service workers, and the radioactive contamination of a significant land area. The release of radioactive material, over a 10-day period, resulted in millions of Soviets, and other Europeans, being exposed to measurable levels of radioactive fallout. Because of the effects of wind and rain, the radioactive nuclide fallout distribution patterns are not well defined, though they appear to be focused in three contiguous Soviet Republics: the Ukrainian SSR, the Byelorussian SSR, and the Russian Soviet Federated Socialist Republic. Further, because of the many radioactive nuclides (krypton, xenon, cesium, iodine, strontium, plutonium) released by the prolonged fires at Chernobyl, the long-term medical, psychological, social, and economic effects will require careful and prolonged study. Specifically, studies on the medical (leukemia, cancers, thyroid disease) and psychological (reactive depressions, post-traumatic stress disorders, family disorganization) consequences of continued low dose radiation exposure in the affected villages and towns need to be conducted so that a coherent, comprehensive, community-oriented plan may evolve that will not cause those already affected any additional harm and confusion. JF - Public health reports (Washington, D.C. : 1974) AU - Ginzburg, H M AU - Reis, E AD - Office of Emergency Preparedness, Health Resources and Services Administration, Public Health Service, Rockville, MD 20857. PY - 1991 SP - 32 EP - 40 VL - 106 IS - 1 SN - 0033-3549, 0033-3549 KW - Radioactive Fallout KW - 0 KW - Radioactive Pollutants KW - Abridged Index Medicus KW - Index Medicus KW - Ukraine -- epidemiology KW - Health Services Needs and Demand KW - Animals KW - Neoplasms, Radiation-Induced -- etiology KW - Humans KW - Radioactive Pollutants -- analysis KW - Food Contamination, Radioactive KW - Neoplasms, Radiation-Induced -- mortality KW - Morbidity KW - USSR KW - Radioactive Fallout -- adverse effects KW - Accidents -- mortality KW - Nuclear Reactors KW - Accidents -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80454530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Consequences+of+the+nuclear+power+plant+accident+at+Chernobyl.&rft.au=Ginzburg%2C+H+M%3BReis%2C+E&rft.aulast=Ginzburg&rft.aufirst=H&rft.date=1991-01-01&rft.volume=106&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-22 N1 - Date created - 1991-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1987 Oct 30;238(4827):622-3 [3672115] Am J Orthopsychiatry. 1990 Jan;60(1):35-42 [2407129] Public Health Rep. 1979 Nov-Dec;94(6):495-502 [515335] Am J Psychiatry. 1976 Mar;133(3):295-9 [1259039] Erratum In: Public Health Rep 1991 May-Jun;106(3):352 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Job dimensions associated with severe disability due to cardiovascular disease. AN - 80451933; 1825324 AB - This study explored associations among job activities and disability due to cardiovascular disease by merging national disability data with independently-obtained job activity data. Disability data were taken from a 1978 U.S. health interview survey (n = 9855). Expert ratings of job activities (dimensions) were obtained from a job analysis database (n = 2485 occupations). The two databases were merged such that job dimension data were imputed to each occupation in the disability database. Odds ratios for cardiovascular disability were calculated for scores in the second, third, and fourth quartiles for each of the 32 job dimensions, using scores in the first quartile as the standard. Job dimensions associated with cardiovascular disability were (a) hazardous situations; (b) vigilant work and responsibility for others; (c) exchanging job-related information; and (d) attention to devices. Occupations identified with high scores on these job dimensions included transportation jobs (air traffic controllers, airline pilots and attendants, bus drivers, locomotive engineers, truck drivers), teachers (preschool, adult education), and craftsmen/foremen (machinists, carpenters, and foremen). JF - Journal of clinical epidemiology AU - Murphy, L R AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 155 EP - 166 VL - 44 IS - 2 SN - 0895-4356, 0895-4356 KW - Index Medicus KW - Environment KW - Age Factors KW - Discriminant Analysis KW - Educational Status KW - Sex Factors KW - Humans KW - Interpersonal Relations KW - Marriage KW - Risk Factors KW - Mental Processes KW - Physical Exertion KW - Adult KW - Databases, Factual KW - Middle Aged KW - Female KW - Male KW - Stress, Psychological -- complications KW - Cardiovascular Diseases -- etiology KW - Occupational Diseases -- etiology KW - Job Description KW - Disabled Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80451933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Job+dimensions+associated+with+severe+disability+due+to+cardiovascular+disease.&rft.au=Murphy%2C+L+R&rft.aulast=Murphy&rft.aufirst=L&rft.date=1991-01-01&rft.volume=44&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-27 N1 - Date created - 1991-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pesticide residues in foods imported into the United States. AN - 80442756; 1994461 AB - Interest in pesticide residues in foods has increased, and the issue of residues in imported foods has been raised as a potential public health problem. Three U.S. government agencies, EPA, FDA, and USDA, are responsible for regulating pesticides. EPA sets tolerances, and FDA and USDA enforce those tolerances. As part of its regulatory activities, FDA conducts a regulatory monitoring program that samples and analyzes each year approximately 20,000 food shipments, about 60% of which are imports. Samples of imported foods are collected at ports of entry, and are chosen on the basis of several factors rather than on a completely random basis. Raw agricultural products are emphasized. Most analyses are performed using MRMs, to make best use of FDA's resources. Using five MRMs, about half of the 300 pesticides with U.S. tolerances can be determined. Results from monitoring over the past several years have shown that nearly 60% of the imported foods sampled had no pesticide residues detected. Of those samples that were violative, 5% contained residues for which there was no U.S. tolerance, and less than 1% had over-tolerance residues. Examples are given of the various pesticide/commodity combinations that have been found to be violative. FDA is often criticized for the scope of its pesticide coverage, particularly with regard to imported foods. Some critics have promoted the idea of a 'circle of poison,' which is based on the premise that pesticides banned in the U.S. are exported and used on foods in foreign countries; then the food containing these residues is imported into the U.S. and consumed. However, FDA's testing of imported foods has shown that residues of EPA-banned pesticides are not occurring from currently purposeful uses. The violation rates for imports also have not been significantly different from those for domestic foods. This indicates that foreign producers, as well as domestic growers, generally use pesticides in a manner consistent with EPA requirements. FDA continues to broaden its information-gathering capabilities. As mandated by the PMIA of 1988, FDA will attempt to obtain pesticide use information from countries that are major food exporters to the United States. An improved data management system will also be in place, and a long-range analytical method development plan instituted. Several international organizations address the issue of pesticide residues in foods. Attempts at harmonization of national tolerances for pesticide residues have not been successful, i.e., a number of individual nations have not accepted Codex MRLs.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Reviews of environmental contamination and toxicology AU - Wessel, J R AU - Yess, N J AD - Food and Drug Administration, Office of Regulatory Affairs, Rockville, MD 20857. Y1 - 1991 PY - 1991 DA - 1991 SP - 83 EP - 104 VL - 120 SN - 0179-5953, 0179-5953 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - United States Environmental Protection Agency KW - Humans KW - Government Agencies KW - Legislation, Drug KW - Food Contamination -- analysis KW - Pesticide Residues -- analysis KW - Food Supply -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80442756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+environmental+contamination+and+toxicology&rft.atitle=Pesticide+residues+in+foods+imported+into+the+United+States.&rft.au=Wessel%2C+J+R%3BYess%2C+N+J&rft.aulast=Wessel&rft.aufirst=J&rft.date=1991-01-01&rft.volume=120&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Reviews+of+environmental+contamination+and+toxicology&rft.issn=01795953&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-18 N1 - Date created - 1991-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenic potency correlations: real or artifactual? AN - 80418481; 1987359 AB - It has been suggested by various investigators that observed interspecies correlations of carcinogenic potency estimates based on bioassays are to a degree due to tautologous aspects of experimental designs. Some authors have even suggested that carcinogenic potency estimates derived from chronic bioassays are little more than experimental design artifacts. In this paper it is argued that constraints imposed by the use of the one-hit model to estimate carcinogenic potency are more restrictive than potential experimental design constraints. JF - Journal of toxicology and environmental health AU - Kodell, R L AU - Gaylor, D W AU - Chen, J J AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 1 EP - 9 VL - 32 IS - 1 SN - 0098-4108, 0098-4108 KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Female KW - Carcinogenicity Tests -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80418481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Carcinogenic+potency+correlations%3A+real+or+artifactual%3F&rft.au=Kodell%2C+R+L%3BGaylor%2C+D+W%3BChen%2C+J+J&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-01-01&rft.volume=32&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-21 N1 - Date created - 1991-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of the in vitro unscheduled DNA synthesis assay in primary lung cells of the rat. AN - 80364192; 1986285 AB - The in vitro unscheduled DNA synthesis (UDS) assay has been evaluated in rat primary lung cells with known genotoxicants. The autoradiographic method was employed to detect UDS in both alveolar macrophages and primary pulmonary cells. Data of a time course study revealed that a high radioactive labeling of DNA repair was achieved after a 16-h incubation with [3H]thymidine. Coupled with low serum (1%), hydroxyurea at the concentration of 20 mM inhibited regular DNA synthesis in primary lung cells in a satisfactory manner (81-88% inhibition). With this protocol, a dose-related increase in UDS was induced by N-methyl-N'-nitro-N-nitrosoguanidine and 2-aminoanthracene in both rat alveolar macrophages and primary lung cells. The results suggest that primary rat lung cells in culture possess DNA-repair ability and that the UDS assay may be useful for assessing the pulmonary genotoxic effect of chemicals in this cell system. JF - Mutation research AU - Whong, W Z AU - Stewart, J D AU - Ong, T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 51 EP - 55 VL - 262 IS - 1 SN - 0027-5107, 0027-5107 KW - Anthracenes KW - 0 KW - Mutagens KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - 2-anthramine KW - 8240818JGU KW - DNA KW - 9007-49-2 KW - Hydroxyurea KW - X6Q56QN5QC KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Anthracenes -- pharmacology KW - Dose-Response Relationship, Drug KW - Methylnitronitrosoguanidine -- pharmacology KW - In Vitro Techniques KW - Hydroxyurea -- pharmacology KW - Mutagens -- pharmacology KW - Autoradiography KW - Male KW - Macrophages -- metabolism KW - Mutagenicity Tests -- methods KW - Lung -- metabolism KW - DNA -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80364192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Characterization+of+the+in+vitro+unscheduled+DNA+synthesis+assay+in+primary+lung+cells+of+the+rat.&rft.au=Whong%2C+W+Z%3BStewart%2C+J+D%3BOng%2C+T&rft.aulast=Whong&rft.aufirst=W&rft.date=1991-01-01&rft.volume=262&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-12 N1 - Date created - 1991-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral contraceptive estrogen dose and the risk of deep venous thromboembolic disease. AN - 80358726; 1983896 AB - Despite the well-recognized association between oral contraceptives and deep venous thromboembolism, little is known about the risks associated with currently marketed formulations containing less than 50 micrograms of estrogen. To assess the venous thrombogenicity of low-estrogen oral contraceptives (those containing less than 50 micrograms of estrogen) relative to intermediate-dose (50 micrograms of estrogen) and high-dose (greater than 50 micrograms of estrogen) formulations, we conducted a cohort study of oral contraceptive users between the ages of 15 and 44 years in the Michigan Medicaid population. The period of the study was from 1980 through the third quarter of 1986. A total of 2,739,400 oral contraceptive prescriptions received by 234,218 women were analyzed. Using the low-estrogen cohort as the referent group, the age and calendar period adjusted relative risk of venous thromboembolism in users of intermediate-dose formulations was 1.5 (95% confidence interval (CI) 1.0-2.1, p = 0.04), and the relative risk in users of high-dose formulations was 1.7 (95% CI 0.9-3.0, p = 0.06). These data provide evidence that the dose-response relation between oral contraceptive estrogen and venous thromboembolism extends from 50 to 30 micrograms of estrogen, the dose range of currently marketed formulations. JF - American journal of epidemiology AU - Gerstman, B B AU - Piper, J M AU - Tomita, D K AU - Ferguson, W J AU - Stadel, B V AU - Lundin, F E AD - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 32 EP - 37 VL - 133 IS - 1 SN - 0002-9262, 0002-9262 KW - Contraceptives, Oral KW - 0 KW - Estrogens KW - Index Medicus KW - Risk Factors KW - Humans KW - Confounding Factors (Epidemiology) KW - Female KW - Contraceptives, Oral -- administration & dosage KW - Thromboembolism -- epidemiology KW - Chemistry, Pharmaceutical -- statistics & numerical data KW - Thromboembolism -- chemically induced KW - Estrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80358726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Oral+contraceptive+estrogen+dose+and+the+risk+of+deep+venous+thromboembolic+disease.&rft.au=Gerstman%2C+B+B%3BPiper%2C+J+M%3BTomita%2C+D+K%3BFerguson%2C+W+J%3BStadel%2C+B+V%3BLundin%2C+F+E&rft.aulast=Gerstman&rft.aufirst=B&rft.date=1991-01-01&rft.volume=133&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-17 N1 - Date created - 1991-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Epidemiol. 1991 Nov 1;134(9):1009; author reply 1009-10 [1951289] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of micronuclei in rat bone marrow by four model compounds. AN - 72750957; 1687903 AB - Studies have been performed to determine the dose and sampling time responses of micronuclei after Sprague-Dawley rats were treated with triethylenemelamine, mitomycin C. dimethylbenzanthracene, and vincristine by a single intraperitoneal injection. Three doses were tested for each compound. Animals were sacrificed 24, 48, and 72 h after chemical treatment. Slides prepared from the bone marrow were stained with May-Gruenwald and Giemsa stains. The number of micronucleated polychromatic erythrocytes among 2,000 polychromatic erythrocytes (PCEs) and the ratio of PCEs to normochromatic erythrocytes were determined for each animal. The results show that all four compounds cause micronucleus formation in rat bone marrow. The peak response sampling time, either 24 or 48 h posttreatment, is dependent on the chemical as well as the dose. In all cases, however, an increase in the micronucleated PCEs was detected 24 h after chemical treatment. These results seem to indicate that two sampling times, 24 and 48 h, may be adequate for the micronucleus assay using rat bone marrow cells. JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Shi, X C AU - Krishna, G AU - Ong, T M AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888. Y1 - 1991 PY - 1991 DA - 1991 SP - 251 EP - 258 VL - 11 IS - 5 SN - 0270-3211, 0270-3211 KW - Mitomycin KW - 50SG953SK6 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Vincristine KW - 5J49Q6B70F KW - Triethylenemelamine KW - F7IY6HZG9D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Erythrocytes -- drug effects KW - Animals KW - Micronucleus Tests KW - Time Factors KW - Male KW - Triethylenemelamine -- toxicity KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Mitomycin -- toxicity KW - Bone Marrow -- ultrastructure KW - Bone Marrow -- drug effects KW - Vincristine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Induction+of+micronuclei+in+rat+bone+marrow+by+four+model+compounds.&rft.au=Shi%2C+X+C%3BKrishna%2C+G%3BOng%2C+T+M&rft.aulast=Shi&rft.aufirst=X&rft.date=1991-01-01&rft.volume=11&rft.issue=5&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-30 N1 - Date created - 1992-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative study of micronucleus assay and chromosomal aberration analysis in V79 cells exposed to ethylene oxide. AN - 72750926; 1687900 AB - Micronucleus formation and chromosomal aberration (CA) in V79 cells were compared for their sensitivity in response to ethylene oxide (EtO) treatment. The results indicate that EtO exposure for 30 min induced CAs in V79 cells at the concentration of 3,500 ppm or higher. A statistically significant difference (P less than 0.01) was found between treated and control groups at all concentrations tested based on percent aberrant cells. The increase was dose-dependent with a correlation coefficient of 0.88. The aberrations found include chromatid and isochromatid breaks, fragments, minutes, and exchanges. Results of the micronucleus assay both in mononucleated and binucleated cells showed a slight but not statistically significant increase in micronuclei with doses between 457 to 4115 ppm. At the highest concentration tested (12344 ppm) EtO caused a significant increase in the micronucleus frequency (P less than 0.05). JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Zhong, B Z AU - Gu, Z W AU - Whong, W Z AU - Wallace, W E AU - Ong, T M AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888. Y1 - 1991 PY - 1991 DA - 1991 SP - 227 EP - 233 VL - 11 IS - 5 SN - 0270-3211, 0270-3211 KW - Ethylene Oxide KW - JJH7GNN18P KW - Index Medicus KW - Animals KW - Cricetulus KW - Lung KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Cell Division -- drug effects KW - Male KW - Cricetinae KW - Fibroblasts -- drug effects KW - Micronucleus Tests KW - Chromosome Aberrations KW - Fibroblasts -- ultrastructure KW - Ethylene Oxide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Comparative+study+of+micronucleus+assay+and+chromosomal+aberration+analysis+in+V79+cells+exposed+to+ethylene+oxide.&rft.au=Zhong%2C+B+Z%3BGu%2C+Z+W%3BWhong%2C+W+Z%3BWallace%2C+W+E%3BOng%2C+T+M&rft.aulast=Zhong&rft.aufirst=B&rft.date=1991-01-01&rft.volume=11&rft.issue=5&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-30 N1 - Date created - 1992-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The epidemiology of populations exposed to dioxin. AN - 72750777; 1817104 JF - IARC scientific publications AU - Fingerhut, M A AU - Sweeney, M H AU - Halperin, W E AU - Schnorr, T M AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 31 EP - 50 IS - 108 SN - 0300-5038, 0300-5038 KW - Carcinogens, Environmental KW - 0 KW - Dioxins KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Dioxins -- adverse effects KW - Carcinogens, Environmental -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=The+epidemiology+of+populations+exposed+to+dioxin.&rft.au=Fingerhut%2C+M+A%3BSweeney%2C+M+H%3BHalperin%2C+W+E%3BSchnorr%2C+T+M&rft.aulast=Fingerhut&rft.aufirst=M&rft.date=1991-01-01&rft.volume=&rft.issue=108&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-07 N1 - Date created - 1992-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of pneumoconiosis interpretation between Chinese and American readers and classifications. AN - 72741224; 1819033 AB - As a preliminary step in joint Sino-American pneumoconiosis research efforts, a formal chest X-ray pneumoconiosis reading trial was conducted among Chinese and American radiologists. Twelve Chinese readers from different institutions located in south central China used the 1986 Chinese Roentgenodiagnostic Criteria of Pneumoconioses. Three American radiologists, centified as NIOSH "B" readers, used the International Labour Office Classification of Pneumoconioses. The chest X-ray study set consisted of 150 posterior-anterior films. One-half were Chinese X-rays of silica-exposed workers, and the other half were American films of variously exposed workers but primarily coal miners. All readings were done independently. The results showed that the inter-reader variability among the Chinese was similar to that of the American readers, both being in an acceptable range. In addition, there was general agreement between the Chinese and American interpretations. For small opacity profusion, the Chinese readers tended to read slightly more diseases than their American counterparts, although there was exact agreement as to the major category in two-thirds of the films. Agreement for film quality, and pleural disease was less, but was not different from reported variation among American "B" readers. Overall, the results suggest that despite the use of two different classification systems, a valid correspondence exists between the Chinese and American Interpretations, which is suitable for use in epidemiologic research. JF - Journal of Tongji Medical University = Tong ji yi ke da xue xue bao AU - Hodous, T K AU - Chen, R A AU - Kinsley, K B AU - Liu, X T AU - McLaughlin, J K AU - Chen, J Q AU - Wu, Z E AU - Blot, W J AD - Division of Respiratory Disease Studies, NIOSH, Morgantown, WV. Y1 - 1991 PY - 1991 DA - 1991 SP - 225 EP - 229 VL - 11 IS - 4 SN - 0257-716X, 0257-716X KW - Index Medicus KW - United States KW - Silicosis -- diagnostic imaging KW - Humans KW - Reference Standards KW - Anthracosilicosis -- diagnostic imaging KW - Coal Mining KW - Radiography KW - China KW - Pneumoconiosis -- diagnostic imaging KW - Pneumoconiosis -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72741224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Tongji+Medical+University+%3D+Tong+ji+yi+ke+da+xue+xue+bao&rft.atitle=A+comparison+of+pneumoconiosis+interpretation+between+Chinese+and+American+readers+and+classifications.&rft.au=Hodous%2C+T+K%3BChen%2C+R+A%3BKinsley%2C+K+B%3BLiu%2C+X+T%3BMcLaughlin%2C+J+K%3BChen%2C+J+Q%3BWu%2C+Z+E%3BBlot%2C+W+J&rft.aulast=Hodous&rft.aufirst=T&rft.date=1991-01-01&rft.volume=11&rft.issue=4&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Tongji+Medical+University+%3D+Tong+ji+yi+ke+da+xue+xue+bao&rft.issn=0257716X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-21 N1 - Date created - 1992-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of Drosophila for screening developmental toxicants: test results with eighteen chemicals and presentation of a new Drosophila bioassay. AN - 72685917; 1686822 AB - The objective of this study was to generate a comprehensive data set of chemically induced malformations in Drosophila using a detailed morphological examination of the entire fly (phase one). These data were analyzed, in blind, with the goal of developing a standardized set of criteria which could be used in a new, rapid, and economical Drosophila bioassay useful in the preliminary screening for potential developmental toxicants. After 32 chemicals were tested, formalized criteria were developed to form the basis of a new Drosophila bioassay. These criteria were then applied to the data from the same 32 chemicals (phase two). The data from only 18 of these chemicals met all requirements for evaluation, e.g., statistical significance, minimum fly numbers, sufficient challenge concentration administered, etc. In the new bioassay, rather than the detailed and time-consuming examination of the entire fly for a multitude of morphological defects, only two specific anatomical sites are examined. These sites are the humeral bristle and the wing blade, with focus placed on two structural defects--a bent bristle and a notch in the wing. These defects were the only two external malformations among the multitude of defects observed in flies treated in the first phase with the 32 chemicals which demonstrated the following characteristics: 1) A consistent concentration-response in flies treated with a variety of developmental toxicants; 2) a lack of response with most presumptive non-developmental toxicants; and 3) consistently low-background incidences in control flies. In both phases, developing Drosophila were exposed to the test agents from the egg through three larval stages by incorporating a range of concentrations of each chemical into the culture medium. Emerging adults were examined for an array of defects as part of a detailed morphological examination in the first phase, including bent bristles and wing notches. In the second phase, only bent bristle and wing notch data were evaluated. The incidences of bent humeral bristles and wing notches from flies exposed to each of the 18 chemicals were compared with those of concurrent controls. Of the 18 chemicals that could be evaluated using the new bioassay, 13 were known developmental toxicants while the remaining 5 were presumptive negative agents. Ten of the 13 mammalian developmental toxicants were correctly identified with this test (false negative rate of 23%). Four of five apparent non-developmental toxicants were correctly identified for a false positive rate of 20%.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Lynch, D W AU - Schuler, R L AU - Hood, R D AU - Davis, D G AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226-1998. Y1 - 1991 PY - 1991 DA - 1991 SP - 147 EP - 173 VL - 11 IS - 3 SN - 0270-3211, 0270-3211 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Dose-Response Relationship, Drug KW - Biological Assay -- methods KW - Drosophila melanogaster -- growth & development KW - Abnormalities, Drug-Induced KW - Drosophila melanogaster -- drug effects KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72685917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Evaluation+of+Drosophila+for+screening+developmental+toxicants%3A+test+results+with+eighteen+chemicals+and+presentation+of+a+new+Drosophila+bioassay.&rft.au=Lynch%2C+D+W%3BSchuler%2C+R+L%3BHood%2C+R+D%3BDavis%2C+D+G&rft.aulast=Lynch&rft.aufirst=D&rft.date=1991-01-01&rft.volume=11&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-13 N1 - Date created - 1992-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of rat lymphocyte activation of benzo[a]pyrene, 2-acetylaminofluorene, and several of their metabolites to mutagenic and DNA-damaging species in vitro. AN - 72668891; 1686675 AB - Rat lymphocytes are a potentially useful and convenient cell system for monitoring the genotoxic effects of chemicals in vivo, but little is known about the ability of these cells to metabolize promutagens to genotoxic species. In this study, Fischer 344 rat lymphocytes were treated in vitro with benzo[a]pyrene (BaP), 2-acetylaminofluorene (2-AAF), and several of their metabolites, and DNA damage was measured using nucleoid sedimentation analysis. Of the BaP derivatives, BaP 4,5-oxide and BaP 7,8-diol-9, 10-epoxide decreased lymphocyte nucleoid sedimentation, whereas BaP and BaP 7,8-dihydrodiol had little effect. Among the 2-AAF derivatives, N-acetoxy-2-AAF, N-hydroxy-2-AAF, and N-hydroxy-2-aminofluorene damaged rat lymphocyte nucleoids, whereas 2-AAF, 2-aminofluorene, and fluorene produced little detectable damage. The decrease in nucleoid sedimentation produced by N-hydroxy-2-AAF was not inhibited by paraoxon, salicylamide, or 2-aminofluorene, whereas paraoxon inhibited damage produced by N-acetoxy-2-AAF. In co-culture assays, rat lymphocytes increased the mutagenicity of N-hydroxy-2-AAF in Salmonella typhimurium strain TA98, but mediated little or no mutagenic response with BaP, BaP 7,8-dihydrodiol, and 2-AAF. Also, human lymphocytes, but not rat lymphocytes, mediated a positive mutagenic response with BaP 7,8-dihydrodiol in Chinese hamster ovary UV5 cells. Although rat lymphocytes may metabolize certain proximal genotoxic chemicals to DNA-damaging species (e.g., N-hydroxy-2-AAF), these data suggest that in vivo lymphocyte DNA damage is more likely to result from lymphocytes encountering reactive chemical derivatives produced by other cells. It is also clear that differences exist between the ability of human and rat lymphocytes to activate promutagens, and this may impact on the use of the rat model to predict the genotoxicity of chemicals in humans. JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Gao, N AU - Aidoo, A AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 65 EP - 76 VL - 11 IS - 2 SN - 0270-3211, 0270-3211 KW - DNA, Superhelical KW - 0 KW - Mutagens KW - Benzo(a)pyrene KW - 3417WMA06D KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - CHO Cells -- metabolism KW - Cells, Cultured KW - Biotransformation KW - Salmonella typhimurium -- drug effects KW - DNA, Superhelical -- metabolism KW - Male KW - Cricetinae KW - 2-Acetylaminofluorene -- metabolism KW - DNA Damage KW - Mutagens -- metabolism KW - Lymphocytes -- metabolism KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72668891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Analysis+of+rat+lymphocyte+activation+of+benzo%5Ba%5Dpyrene%2C+2-acetylaminofluorene%2C+and+several+of+their+metabolites+to+mutagenic+and+DNA-damaging+species+in+vitro.&rft.au=Gao%2C+N%3BAidoo%2C+A%3BHeflich%2C+R+H&rft.aulast=Gao&rft.aufirst=N&rft.date=1991-01-01&rft.volume=11&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-06 N1 - Date created - 1992-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contribution of biological markers to occupational health. AN - 72659358; 1785610 AB - Occupational diseases are now being assessed at the cellular and molecular levels; this presents new opportunities for prevention and control [Calleman et al., 1978; Ong et al., 1987; Stejskal et al., 1989; Welch and Cullen, 1988; Garry et al., 1989]. The key to these opportunities is the ability to detect biological markers that reflect exposure, response, and susceptibility. Biological markers are not new, however. Biological markers such as blood lead, urinary phenol levels in benzene exposure, and liver function assays have long been used in occupational and public health research and practice. What distinguishes the current generation of markers from previous markers is a greater degree of analytical sensitivity and the ability to describe events that occur earlier in the progression between exposure and clinical disease. There are now new domains of response that were not known to exist 20 years ago. Accompanying this sensitivity is the increased requirement to consider the numerous factors that can influence the appearance of biological markers. It has been observed that all workers with similar exposures do not develop disease or markers indicative of exposure or disease. Various acquired and hereditary host factors are responsible for this variation in responses. The role of assessing the nature and degree of variation between individuals is of paramount importance. Finally, the use of biological markers in occupational health research and practice also brings new ethical and legal considerations into high profile. This paper presents my personal opinions on how biological markers can contribute to occupational health efforts and the new requirements that they bring to the field. As with any technological change, the more we can anticipate the impact, the better our ability to adjust. JF - American journal of industrial medicine AU - Schulte, P A AD - Screening & Notification Section, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. Y1 - 1991 PY - 1991 DA - 1991 SP - 435 EP - 446 VL - 20 IS - 4 SN - 0271-3586, 0271-3586 KW - Biomarkers KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Environmental Monitoring KW - Reproducibility of Results KW - Humans KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Ethics, Medical KW - Occupational Exposure -- adverse effects KW - Disease Models, Animal KW - Occupational Diseases -- epidemiology KW - Epidemiological Monitoring KW - Research KW - Occupational Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72659358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Contribution+of+biological+markers+to+occupational+health.&rft.au=Schulte%2C+P+A&rft.aulast=Schulte&rft.aufirst=P&rft.date=1991-01-01&rft.volume=20&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-17 N1 - Date created - 1992-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - On the mechanism of action of interferons: interaction with nonsteroidal anti-inflammatory agents, pentoxifylline (Trental) and cGMP inducers. AN - 72648030; 1664849 AB - In earlier studies, we showed that when interferon alpha (IFN alpha) binds to cell receptors, it alters membrane potentials. In IFN-sensitive Daudi cells derived from Burkitt's lymphoma patients, IFNs produce dose-dependent hyperpolarization, decreased plasma membrane viscosity, modulation of the microfilament system, and altered synthesis of cAMP, cGMP and prostaglandins. No such changes were seen in IFN alpha-resistant Daudi cells. In this study, we found that indomethacin, pentoxifylline, or the cGMP inducer sodium azide (NaN3) had no significant effect on the IFN alpha induced membrane potential changes, or on membrane viscosity changes as measured by flow cytometry and electron spin resonance spectrometry. In tissue culture, indomethacin did not alter the anti-proliferative effect of IFN alpha on Daudi cells. Indomethacin may influence IFN synthesis, but not it's antiproliferative actions. Relatively high doses of pentoxifylline slightly inhibited proliferation of Daudi cells and synergized with IFN alpha. Measurement of early biophysical changes induced by IFNs may represent a new screening method to rapidly explore certain types of IFN alpha potentiating agents. JF - Journal of medicine AU - Aszalos, A AU - Grimley, P M AU - Balint, E AU - Chadha, K C AU - Ambrus, J L AD - Division of Research and Testing, FDA, Washington, DC. Y1 - 1991 PY - 1991 DA - 1991 SP - 255 EP - 271 VL - 22 IS - 4-5 SN - 0025-7850, 0025-7850 KW - Azides KW - 0 KW - Interferon-alpha KW - Sodium Azide KW - 968JJ8C9DV KW - Cyclic GMP KW - H2D2X058MU KW - Pentoxifylline KW - SD6QCT3TSU KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Drug Interactions KW - Cyclic GMP -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Electron Spin Resonance Spectroscopy KW - In Vitro Techniques KW - Membrane Potentials -- drug effects KW - Burkitt Lymphoma -- pathology KW - Pentoxifylline -- pharmacology KW - Interferon-alpha -- metabolism KW - Azides -- pharmacology KW - Interferon-alpha -- physiology KW - Indomethacin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72648030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicine&rft.atitle=On+the+mechanism+of+action+of+interferons%3A+interaction+with+nonsteroidal+anti-inflammatory+agents%2C+pentoxifylline+%28Trental%29+and+cGMP+inducers.&rft.au=Aszalos%2C+A%3BGrimley%2C+P+M%3BBalint%2C+E%3BChadha%2C+K+C%3BAmbrus%2C+J+L&rft.aulast=Aszalos&rft.aufirst=A&rft.date=1991-01-01&rft.volume=22&rft.issue=4-5&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicine&rft.issn=00257850&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-24 N1 - Date created - 1992-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Infectious diseases and drug abuse. Prevention and treatment in the drug abuse treatment system. AN - 72644717; 1787552 AB - Several communicable infectious diseases, including AIDS, hepatitis B infection, gonorrhea, syphilis, and tuberculosis, are increasing among drug abusers. Drug abuse treatment programs may be ideal sites to identify those infections and initiate and maintain appropriate medical management. This paper reviews the epidemiology of those infections among drug abusers in the USA, presents rudimentary aspects of medical management of selected infectious diseases, and discusses the need to integrate infectious diseases, drug abuse treatment, and public health approaches if we are to reverse, or at least stabilize, the trends of those diseases. JF - Journal of substance abuse treatment AU - Haverkos, H W AD - Division of Clinical Research, National Institute on Drug Abuse, United States Public Health Service, Rockville, Maryland 20857. Y1 - 1991 PY - 1991 DA - 1991 SP - 269 EP - 275 VL - 8 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - AIDS/HIV KW - Gonorrhea -- transmission KW - Hepatitis B -- prevention & control KW - HIV Infections -- transmission KW - Risk Factors KW - Humans KW - HIV Infections -- prevention & control KW - Tuberculosis, Pulmonary -- transmission KW - Tuberculosis, Pulmonary -- prevention & control KW - Syphilis -- transmission KW - Syphilis -- prevention & control KW - Hepatitis B -- transmission KW - Gonorrhea -- prevention & control KW - Communicable Disease Control -- methods KW - Substance Abuse, Intravenous -- rehabilitation KW - Substance Abuse, Intravenous -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72644717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Infectious+diseases+and+drug+abuse.+Prevention+and+treatment+in+the+drug+abuse+treatment+system.&rft.au=Haverkos%2C+H+W&rft.aulast=Haverkos&rft.aufirst=H&rft.date=1991-01-01&rft.volume=8&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-23 N1 - Date created - 1992-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins. AN - 72622463; 1778307 AB - A synthetic peptide corresponding to amino acids 6-17 of the A subunit of pertussis toxin was synthesised and used for the immunization of Balb/c mice and the subsequent production of monoclonal antibodies (MAbs). This peptide contains a region of eight amino acids which is homologous to a region in the cholera toxin A subunit. The properties of two of the resultant MAbs are described. Both of the antibodies (CP7-3003F7, an IgG3 and CP7-3004G6X1, an IgG1) react in an ELISA with the peptide and with intact pertussis toxin, pertussis toxin A subunit and cholera toxin A subunit, but do not react significantly with pertussis toxin B subunit, intact cholera toxin, or cholera toxin B subunit. Competition ELISA assays in which the peptide, the intact toxins and the toxin subunits were compared with respect to their ability to inhibit the binding of the MAbs to peptide-coated ELISA plates demonstrated that only pertussis toxin A subunit was as active, on a molar basis, as the peptide. Western blot analyses of the holotoxins confirmed that both MAbs were reactive only with the toxin A subunits. The MAbs were unable to neutralize the activity of cholera toxin or pertussis toxin in a Chinese hamster ovary (CHO) cell assay. Both were also unable to neutralize either the ADP-ribosylation activity or the NAD-glycohydrolase activity of the pertussis toxin A subunit. The significance of these results with respect to the role of this conserved site in the activity of these two toxins is discussed. JF - Developments in biological standardization AU - Kenimer, J G AU - Probst, P G AU - Karpas, A B AU - Burns, D L AU - Kaslow, H R AD - Laboratory of Cellular Physiology, CBER, FDA, Bethesda, MD 20892. Y1 - 1991 PY - 1991 DA - 1991 SP - 133 EP - 141 VL - 73 SN - 0301-5149, 0301-5149 KW - Antibodies, Monoclonal KW - 0 KW - Peptides KW - Virulence Factors, Bordetella KW - Cholera Toxin KW - 9012-63-9 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Index Medicus KW - Animals KW - Peptides -- immunology KW - Poly(ADP-ribose) Polymerases -- immunology KW - Amino Acid Sequence KW - Mice KW - Mice, Inbred BALB C KW - Molecular Weight KW - Molecular Sequence Data KW - Neutralization Tests KW - CHO Cells KW - Enzyme-Linked Immunosorbent Assay KW - Peptides -- chemistry KW - Cricetinae KW - Virulence Factors, Bordetella -- metabolism KW - Virulence Factors, Bordetella -- chemistry KW - Cholera Toxin -- immunology KW - Virulence Factors, Bordetella -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72622463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developments+in+biological+standardization&rft.atitle=Monoclonal+antibodies+against+the+enzymatic+subunit+of+both+pertussis+and+cholera+toxins.&rft.au=Kenimer%2C+J+G%3BProbst%2C+P+G%3BKarpas%2C+A+B%3BBurns%2C+D+L%3BKaslow%2C+H+R&rft.aulast=Kenimer&rft.aufirst=J&rft.date=1991-01-01&rft.volume=73&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Developments+in+biological+standardization&rft.issn=03015149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-10 N1 - Date created - 1992-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS knowledge, perception of risk, and behaviors among female sex partners of injection drug users. AN - 72619215; 1777343 AB - Interviews were conducted with 137 female sex partners of male injection drug users to provide quantitative and qualitative information regarding their AIDS knowledge, attitudes, and specific risk behaviors. Levels of knowledge regarding HIV transmission and prevention were high, with an average of 81.8% correct on a 16-item test. Most women (87.5%) believed that there was at least some chance they would become HIV infected. Substance abuse was prevalent; 67.2% used non-injection drugs (44.5% used crack cocaine), and 32.1% reported prior use of injection drugs. One fifth had engaged in prostitution. Although AIDS knowledge was high, almost all (94.9%) reported engaging in unprotected vaginal intercourse during the previous 6 months, and 6.6% reported anal intercourse without a condom. Among women who did not report consistent condom use, the most frequently stated reasons for non-use of condoms were dislike by their male partner (26.9%) and/or personal dislike of condoms (23.1%). A disturbing pattern of increased risk was observed among black interviewees, who were more likely than Latinas or whites to have contracted syphilis, have multiple sex partners, engage in prostitution, use crack cocaine, and drink alcohol daily. JF - AIDS education and prevention : official publication of the International Society for AIDS Education AU - Corby, N H AU - Wolitski, R J AU - Thornton-Johnson, S AU - Tanner, W M AD - Long Beach Department of Health and Human Services, CA 90806. Y1 - 1991 PY - 1991 DA - 1991 SP - 353 EP - 366 VL - 3 IS - 4 SN - 0899-9546, 0899-9546 KW - Index Medicus KW - AIDS/HIV KW - Contraceptive Devices, Male -- utilization KW - Risk-Taking KW - Humans KW - European Continental Ancestry Group -- psychology KW - Sexual Behavior KW - African Americans -- psychology KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Hispanic Americans -- psychology KW - Adolescent KW - Urban Population KW - California -- epidemiology KW - Female KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Acquired Immunodeficiency Syndrome -- transmission KW - Health Knowledge, Attitudes, Practice KW - Sexual Partners -- psychology KW - Substance Abuse, Intravenous -- complications KW - Acquired Immunodeficiency Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72619215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention+%3A+official+publication+of+the+International+Society+for+AIDS+Education&rft.atitle=AIDS+knowledge%2C+perception+of+risk%2C+and+behaviors+among+female+sex+partners+of+injection+drug+users.&rft.au=Corby%2C+N+H%3BWolitski%2C+R+J%3BThornton-Johnson%2C+S%3BTanner%2C+W+M&rft.aulast=Corby&rft.aufirst=N&rft.date=1991-01-01&rft.volume=3&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention+%3A+official+publication+of+the+International+Society+for+AIDS+Education&rft.issn=08999546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nuclear protein phosphorylation in rat cerebral cells following acute exposure to ethanol. AN - 72564840; 1756189 AB - The sequelae of acute ethanol toxicity encompass a broad spectrum of metabolic and cellular derangements, including the induction of stress proteins in cells exposed to high levels of ethanol. In this investigation, the effects of ethanol exposure on nuclear protein synthesis and phosphorylation were compared by two-dimensional gel electrophoresis in glial-enriched cultures, adult rat cerebrum and regenerated liver. Cellular exposure to ethanol was at clinically relevant levels and tissue was analyzed at 1 h and 48 h after exposure. Cell nuclei were stained with propidium iodide, a DNA specific fluorochrome and flow cytometrically sorted to obtain cell cycle phase populations of nuclei for analysis. Ethanol treatment of intact rats and glial-enriched cultures induced phosphorylation of specific nuclear proteins, which were detected by two-dimensional electrophoresis and autoradiography. The autoradiographs of [32P]phosphate and [3H]leucine labeled proteins from glial-enriched cultures and from the G0/G1 phase of the regenerating liver tissue exhibited intense labeling indicative of active protein synthesis and phosphorylation. In contrast, the autoradiographs of proteins from adult rat cerebra showed substantial phosphorylation, but weak protein synthesis. Ethanol treatment was associated with phosphorylation of a 50,000 Mr protein in G0/G1 phase cells of the cultures and in predominantly G0 cells of the adult rat cerebra. A protein with similar characteristics was not found in ethanol exposed regenerating rat liver tissue and has not been observed in other 'heat shock' or 'stress' protein systems which we have previously studied. JF - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society AU - Hinson, W G AU - Pipkin, J L AU - Anson, J F AU - Davies, D L AU - Burns, E R AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72205-9502. Y1 - 1991 PY - 1991 DA - 1991 SP - 93 EP - 99 VL - 2 IS - 2-3 SN - 0954-6642, 0954-6642 KW - Indicators and Reagents KW - 0 KW - Nuclear Proteins KW - Phosphates KW - Phosphoproteins KW - Phosphorus Radioisotopes KW - Tritium KW - 10028-17-8 KW - Ethanol KW - 3K9958V90M KW - Leucine KW - GMW67QNF9C KW - Index Medicus KW - Animals KW - Electrophoresis, Gel, Two-Dimensional -- methods KW - Liver -- metabolism KW - Liver Regeneration KW - Molecular Weight KW - Rats, Inbred Strains KW - Rats KW - Phosphates -- metabolism KW - Phosphorylation KW - Cells, Cultured KW - Kinetics KW - Leucine -- metabolism KW - Female KW - Neuroglia -- metabolism KW - Nuclear Proteins -- isolation & purification KW - Ethanol -- pharmacology KW - Brain -- pathology KW - Brain -- drug effects KW - Ethanol -- toxicity KW - Brain -- metabolism KW - Neuroglia -- drug effects KW - Phosphoproteins -- isolation & purification KW - Nuclear Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72564840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Nuclear+protein+phosphorylation+in+rat+cerebral+cells+following+acute+exposure+to+ethanol.&rft.au=Hinson%2C+W+G%3BPipkin%2C+J+L%3BAnson%2C+J+F%3BDavies%2C+D+L%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Hinson&rft.aufirst=W&rft.date=1991-01-01&rft.volume=2&rft.issue=2-3&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-04 N1 - Date created - 1992-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of Salmonella typhimurium hisD3052 revertants: the use of oligodeoxyribonucleotide colony hybridization, PCR, and direct sequencing in mutational analysis. AN - 72561862; 1748083 AB - A rapid method for determining the DNA sequences of Salmonella typhimurium hisD3052 revertants is presented. DNA colony hybridization was used to analyze revertants previously studied by Isono and Yourno [Proc Natl Acad Sci USA 71:1612-1617, 1974]. Synthetic oligodeoxyribonucleotide probes (18-mers) were able to distinguish sequences that differed by a single base pair. Mutant his sequences not identified by probing analysis were amplified using polymerase chain reaction (PCR) and directly sequenced. The combined use of DNA-colony hybridization and direct sequencing offers a precise and rapid means for the molecular characterization of hisD3052 revertants. JF - Environmental and molecular mutagenesis AU - Kupchella, E AU - Cebula, T A AD - Molecular Biology Branch, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 224 EP - 230 VL - 18 IS - 4 SN - 0893-6692, 0893-6692 KW - hisD KW - Oligonucleotide Probes KW - 0 KW - Histidine KW - 4QD397987E KW - Index Medicus KW - Polymerase Chain Reaction KW - Base Sequence KW - Molecular Sequence Data KW - Oligonucleotide Probes -- chemistry KW - Nucleic Acid Hybridization KW - Mutagenicity Tests KW - DNA Mutational Analysis KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72561862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Analysis+of+Salmonella+typhimurium+hisD3052+revertants%3A+the+use+of+oligodeoxyribonucleotide+colony+hybridization%2C+PCR%2C+and+direct+sequencing+in+mutational+analysis.&rft.au=Kupchella%2C+E%3BCebula%2C+T+A&rft.aulast=Kupchella&rft.aufirst=E&rft.date=1991-01-01&rft.volume=18&rft.issue=4&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-23 N1 - Date created - 1992-01-23 N1 - Date revised - 2017-01-13 N1 - Gene symbol - hisD N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biodegradation of 1-nitropyrene. AN - 72487641; 1953305 AB - The metabolism of 14C-labeled 1-nitropyrene in microcosms containing nonsterile estuarine sediments, and in cultures of a Mycobacterium sp. previously isolated from oil-contaminated sediments was investigated. Although mineralization of 1-nitropyrene by pure cultures of the Mycobacterium sp. totaled only 12.3% after 10 days of incubation, over 80% of the ethyl acetate extractable 14C-labeled compounds consisted of 1-nitropyrene metabolites. High pressure liquid chromatographic analysis of 1-nitropyrene degradation products indicated that two major metabolites were formed. They were identified as 1-nitropyrene cis-9,10- and 4,5-dihydrodiols, based on their UV-visible, mass and NMR spectra. Time course studies in microcosms showed that 1-nitropyrene was degraded slowly under aerobic and anaerobic conditions in estuarine sediments. Less than 1% had been converted to 14CO2 after 8 weeks of aerobic incubation. The addition of 1-nitropyrene to anaerobic sediments resulted in no 14CO2 evolution; however, the nitro group of 1-nitropyrene was reduced to form 1-aminopyrene. Although the mineralization of 1-nitropyrene in sediments was slow, the Mycobacterium sp. metabolized 1-nitropyrene in pure culture. This bacterium appears promising for the bioremediation of this ubiquitous pollutant in contaminated waste. JF - Archives of microbiology AU - Heitkamp, M A AU - Freeman, J P AU - Miller, D W AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 223 EP - 230 VL - 156 IS - 3 SN - 0302-8933, 0302-8933 KW - Pyrenes KW - 0 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Mass Spectrometry KW - Kinetics KW - Spectrophotometry, Ultraviolet KW - Biodegradation, Environmental KW - Aerobiosis KW - Chromatography, High Pressure Liquid KW - Anaerobiosis KW - Magnetic Resonance Spectroscopy KW - Environmental Pollution -- prevention & control KW - Soil Microbiology KW - Pyrenes -- metabolism KW - Mycobacterium -- metabolism KW - Water Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72487641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Biodegradation+of+1-nitropyrene.&rft.au=Heitkamp%2C+M+A%3BFreeman%2C+J+P%3BMiller%2C+D+W%3BCerniglia%2C+C+E&rft.aulast=Heitkamp&rft.aufirst=M&rft.date=1991-01-01&rft.volume=156&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A model of chronic neurotoxicity: long-term retention of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) within catecholaminergic neurons. AN - 72484083; 1956587 AB - The mechanism by which 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces lesions in the nigrostriatal dopamine system has been extensively studied. MPTP, a lipophilic molecule, enters the brain rapidly where it is converted to the pyridinium metabolite 1-methyl-4-phenylpyridinium (MPP+), by a two-step reaction that requires the enzyme monoamine oxidase. Following this conversion, which occurs primarily in astrocytes, MPP+ is sequestered within monoaminergic neurons by the energy-requiring monoaminergic transporters. Inside the neuron, MPP+ is thought to act as a mitochondrial toxin, slowly sapping the neuron of its energy-producing potential by blocking the action of NADH dehydrogenase. Much attention has been focused on cell death after MPTP administration, but little attention has been paid to the effects of small subtoxic doses of MPTP (i.e., doses that do not produce overt neuropathologic changes), which might occur during environmental exposure to a nigrostriatal toxin. Low doses of MPTP (as little as 1/25th of a toxic dose) produce long-term (greater than 6 weeks) but reversible changes in catecholamine metabolism. These changes are characterized by a decrease in the products of enzymatic oxidative deamination without a concomitant decrease in the amine concentrations (apparent MAO inhibition). Striatal concentrations of MPP+, which is retained in catecholaminergic terminals for similarly long periods, parallel the metabolic changes. Thus, the long-term storage of the MPTP metabolite, MPP+, correlates with altered catecholamine metabolism. The data on the effects of MPTP have been combined into a working model of how MPP+ exerts its effects following subtoxic or toxic doses. The site of this long-term neuronal storage of MPP+ after exposure to subtoxic doses of MPTP is as yet undetermined, but several studies suggest that monoaminergic vesicles may be the primary site, with mitochondria contributing some storage capacity. This vesicular site could represent a potential brain site for the accumulation of toxins during continual or repeated exposure to low levels of MPTP. Induced release from this site might accelerate the toxic interactions with cellular components such as mitochondria. JF - Neurotoxicology AU - Johannessen, J N AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 285 EP - 302 VL - 12 IS - 2 SN - 0161-813X, 0161-813X KW - Catecholamines KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Animals KW - Humans KW - Corpus Striatum -- metabolism KW - Models, Neurological KW - Time Factors KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- pharmacokinetics KW - Neurons -- metabolism KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Catecholamines -- physiology KW - Neurons -- drug effects KW - MPTP Poisoning KW - 1-Methyl-4-phenylpyridinium -- metabolism KW - Basal Ganglia Diseases -- metabolism KW - Basal Ganglia Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72484083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=A+model+of+chronic+neurotoxicity%3A+long-term+retention+of+the+neurotoxin+1-methyl-4-phenylpyridinium+%28MPP%2B%29+within+catecholaminergic+neurons.&rft.au=Johannessen%2C+J+N&rft.aulast=Johannessen&rft.aufirst=J&rft.date=1991-01-01&rft.volume=12&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-02 N1 - Date created - 1992-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of acrylonitrile by Klebsiella pneumoniae. AN - 72480231; 1953306 AB - A gram-negative rod-shaped bacterium capable of utilizing acrylonitrile as the sole source of nitrogen was isolated from industrial sewage and identified as Klebsiella pneumoniae. The isolate was capable of utilizing aliphatic nitriles containing 1 to 5 carbon atoms or benzonitrile as the sole source of nitrogen and either acetamide or propionamide as the sole source of both carbon and nitrogen. Gas chromatographic and mass spectral analyses of culture filtrates indicated that K. pneumoniae was capable of hydrolyzing 6.15 mmol of acrylonitrile to 5.15 mmol of acrylamide within 24 h. The acrylamide was hydrolyzed to 1.0 mmol of acrylic acid within 72 h. Another metabolite of acrylonitrile metabolism was ammonia, which reached a maximum concentration of 3.69 mM within 48 h. Nitrile hydratase and amidase, the two hydrolytic enzymes responsible for the sequential metabolism of nitrile compounds, were induced by acrylonitrile. The optimum temperature for nitrile hydratase activity was 55 degrees C and that for amidase was 40 degrees C; both enzymes had pH optima of 8.0. JF - Archives of microbiology AU - Nawaz, M S AU - Franklin, W AU - Campbell, W L AU - Heinze, T M AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 231 EP - 238 VL - 156 IS - 3 SN - 0302-8933, 0302-8933 KW - Sewage KW - 0 KW - Amidohydrolases KW - EC 3.5.- KW - Hydro-Lyases KW - EC 4.2.1.- KW - nitrile hydratase KW - Acrylonitrile KW - MP1U0D42PE KW - Index Medicus KW - Amidohydrolases -- metabolism KW - Chromatography, Gas KW - Hydrogen-Ion Concentration KW - Temperature KW - Gas Chromatography-Mass Spectrometry KW - Biodegradation, Environmental KW - Substrate Specificity KW - Hydrolysis KW - Hydro-Lyases -- metabolism KW - Klebsiella pneumoniae -- enzymology KW - Water Pollution -- prevention & control KW - Acrylonitrile -- metabolism KW - Water Microbiology KW - Klebsiella pneumoniae -- metabolism KW - Klebsiella pneumoniae -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72480231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Metabolism+of+acrylonitrile+by+Klebsiella+pneumoniae.&rft.au=Nawaz%2C+M+S%3BFranklin%2C+W%3BCampbell%2C+W+L%3BHeinze%2C+T+M%3BCerniglia%2C+C+E&rft.aulast=Nawaz&rft.aufirst=M&rft.date=1991-01-01&rft.volume=156&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development, use, and availability of a job exposure matrix based on national occupational hazard survey data. AN - 72476582; 1951366 AB - A job exposure matrix has been developed based on potential exposure data collected during the 1972-1974 National Occupational Hazard Survey (NOHS). The survey sample was representative of all U.S. non-agricultural businesses covered under the Occupational Safety and Health Act of 1970 and employing eight or more employees. Potential worker exposure to all chemical, physical, or biological agents was recorded during the field survey if certain minimum guidelines for exposure were met. The job exposure matrix (JEM) itself is a computerized database that assists the user in determining potential chemical or physical exposures in occupational settings. We describe the structure and possible uses of the job exposure matrix. In one example, potential occupational exposures to elemental lead were grouped by industry and occupation. In a second example, the matrix was used to determine exposure classifications in a hypothetical case-control study. Present availability as well as future enhancements of the job exposure matrix are described. JF - American journal of industrial medicine AU - Sieber, W K AU - Sundin, D S AU - Frazier, T M AU - Robinson, C F AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 163 EP - 174 VL - 20 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Occupational Health -- legislation & jurisprudence KW - Data Collection -- methods KW - Humans KW - Case-Control Studies KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure -- statistics & numerical data KW - Occupational Exposure -- classification KW - Databases, Factual KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72476582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Development%2C+use%2C+and+availability+of+a+job+exposure+matrix+based+on+national+occupational+hazard+survey+data.&rft.au=Sieber%2C+W+K%3BSundin%2C+D+S%3BFrazier%2C+T+M%3BRobinson%2C+C+F&rft.aulast=Sieber&rft.aufirst=W&rft.date=1991-01-01&rft.volume=20&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-29 N1 - Date created - 1991-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synthesis and biochemical characteristics of nucleoproteins following a toxic dose of retinoic acid in cycling and differentiating HL-60 cells. AN - 72444668; 1932208 AB - Exposure of HL-60 cells to 2 microM retinoic acid (RA), twice the dose necessary for differentiation, initiated rapid synthesis (2 h) of the nuclear stress proteins (SPs) e.g., 90, 70c, 70x, 22 (Mr x 10(-3)) during the G0 + G1 phase of the cell cycle as observed by polyacrylamide gel electrophoresis (PAGE). Synthesis of SPs was cell cycle correlated and not dependent on time-after-dosing, and all labeling disappeared from these proteins within 48 h of RA exposure. Stress proteins were not elicited with a 1 microM dose or less of retinoic acid. Non-stress nuclear proteins revealed changes in synthesis levels (e.g., actin, lamins, tubulins) which were cell cycle related and temporally associated with dosing. A major non-stress nuclear protein (Mr 120,000) which possessed an affinity for actin in binding assays, was cell cycle related in control cells, and was suppressed in synthesis in cells exposed to 2 microM retinoic acid. Two additional nuclear non-SPs 51 and 55 (Mr x 10(-3)) covalently bound the isotope [3H]retinoic acid, and their incorporation was cell cycle correlated during early periods of RA exposure. Except for the induction of SPs, the autoradiographs of nuclear proteins of RA dosed HL-60 cells, showed more quantitative than qualitative changes. JF - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society AU - Pipkin, J L AU - Hinson, W G AU - Anson, J F AU - Schol, H M AU - Lyn-Cook, L E AU - Burns, E R AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 31 EP - 41 VL - 2 IS - 1 SN - 0954-6642, 0954-6642 KW - Actins KW - 0 KW - Biomarkers KW - Heat-Shock Proteins KW - Neoplasm Proteins KW - Nucleoproteins KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Neoplasm Proteins -- biosynthesis KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Actins -- metabolism KW - Cell Differentiation KW - Heat-Shock Proteins -- biosynthesis KW - Heat-Shock Proteins -- isolation & purification KW - Protein Binding KW - Neoplasm Proteins -- isolation & purification KW - Electrophoresis, Gel, Two-Dimensional KW - Tumor Cells, Cultured -- pathology KW - Cell Cycle KW - Nucleoproteins -- biosynthesis KW - Tretinoin -- toxicity KW - Nucleoproteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72444668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Synthesis+and+biochemical+characteristics+of+nucleoproteins+following+a+toxic+dose+of+retinoic+acid+in+cycling+and+differentiating+HL-60+cells.&rft.au=Pipkin%2C+J+L%3BHinson%2C+W+G%3BAnson%2C+J+F%3BSchol%2C+H+M%3BLyn-Cook%2C+L+E%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Pipkin&rft.aufirst=J&rft.date=1991-01-01&rft.volume=2&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-25 N1 - Date created - 1991-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synthesis and phosphorylation of nuclear matrix proteins following a toxic dose of retinoic acid in cycling and differentiating HL-60 cells. AN - 72443585; 1932206 AB - Exposure of HL-60 cells to 2 microM retinoic acid, twice the dose necessary for differentiation, initiated protein synthesis within 2 h exposure in the nuclear matrix proteins and phosphorylation of a subfraction of these proteins, designated the phenol-soluble nuclear proteins. These processes were examined by fluorography of two-dimensional polyacrylamide gels. Three cell-cycle related stress proteins (22, 70c, 70x Mr x 10(-3)), were seen in the nuclear matrix fraction that were synthesized early and disappeared rapidly following dosing with retinoic acid. In control cells, protein 120 was also cell-cycle related and showed modest synthesis in nuclear matrix and strong phosphorylation in phenol-soluble fraction. Within 5 h after dosing, p120 exhibited alteration in phosphorylation as evidenced by mapping of [32P]-labeled peptides. Two nuclear matrix proteins, p52 and p55, incorporated [3H] retinoic acid rapidly, were cell-cycle-related, and disappeared within 12 h of dosing. Progressive increases in the labeling of the nuclear matrix and phenol-soluble nuclear proteins with increasing retinoic acid exposure was apparent in G2-phase at 96 h time-after-dosing. JF - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society AU - Pipkin, J L AU - Hinson, W G AU - Anson, J F AU - Lyn-Cook, L E AU - Burns, E R AU - Casciano, D A AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 17 EP - 29 VL - 2 IS - 1 SN - 0954-6642, 0954-6642 KW - Antigens, Nuclear KW - 0 KW - Biomarkers KW - Heat-Shock Proteins KW - Neoplasm Proteins KW - Nuclear Proteins KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Neoplasm Proteins -- biosynthesis KW - Tumor Cells, Cultured -- metabolism KW - Peptide Mapping KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Cell Differentiation KW - Heat-Shock Proteins -- biosynthesis KW - Phosphorylation KW - Neoplasm Proteins -- isolation & purification KW - Nuclear Matrix -- metabolism KW - Electrophoresis, Gel, Two-Dimensional KW - Tumor Cells, Cultured -- pathology KW - Cell Cycle KW - Neoplasm Proteins -- metabolism KW - Nuclear Proteins -- isolation & purification KW - Tretinoin -- toxicity KW - Nuclear Proteins -- biosynthesis KW - Nuclear Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72443585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Synthesis+and+phosphorylation+of+nuclear+matrix+proteins+following+a+toxic+dose+of+retinoic+acid+in+cycling+and+differentiating+HL-60+cells.&rft.au=Pipkin%2C+J+L%3BHinson%2C+W+G%3BAnson%2C+J+F%3BLyn-Cook%2C+L+E%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Pipkin&rft.aufirst=J&rft.date=1991-01-01&rft.volume=2&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-25 N1 - Date created - 1991-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Virulence, immunity, and vaccine related to Streptococcus pneumoniae. AN - 72174125; 1930677 AB - The pathogenesis of bacterial infection involves a series of interactions between the virulence determinants of the microorganisms and the immunity of the host. Studies on the molecular structure and immunological properties of pneumococcal virulence factors have provided general knowledge for the chemical basis of immunogenicity and prevention of bacterial infection. Antibody responses to PS and protein antigens can be greatly affected by their physicochemical properties, e.g., molecular size, specific determinants, conformation, etc. Characterization of group 19 pneumolysins and cloning of their ply genes were studied to examine the relationship of ply to virulence. Group 19 pneumococci all contained ply; the disease-isolated types of 19F and 19A appeared to show a higher specific hemolytic activity and yield than the nonpathogenic types, 19B and 19C. Genomic DNA that contained the ply gene from group 19 strains were analyzed by the polymerase chain reaction (PCR). Type 2 oligonucleotide primers recognized and initiated synthesis of an identical 1.5 kb DNA fragment in types 2, 19F, 19A, 19B, and 19C. Their sizes of restriction DNA fragments were also found to be homologous. Thus, group 19 ply genes showed remarkably similar characteristics. A difficult problem in the development of vaccines against bacterial diseases is the poor immune response of young children to purified PSs. The efficacy of pneumococcal vaccine might be improved by supplementation with inactivated pneumolysin in the form of a PS-protein conjugate. JF - Critical reviews in microbiology AU - Lee, C J AU - Banks, S D AU - Li, J P AD - Center for Biologics Evaluation and Research, Bethesda, MD 20892. Y1 - 1991 PY - 1991 DA - 1991 SP - 89 EP - 114 VL - 18 IS - 2 SN - 1040-841X, 1040-841X KW - Antigens, Bacterial KW - 0 KW - Bacterial Vaccines KW - Polysaccharides, Bacterial KW - Neuraminidase KW - EC 3.2.1.18 KW - Index Medicus KW - Virulence KW - Animals KW - Humans KW - Molecular Sequence Data KW - Carbohydrate Sequence KW - Polysaccharides, Bacterial -- toxicity KW - Neuraminidase -- toxicity KW - Antigens, Bacterial -- immunology KW - Immunity KW - Bacterial Vaccines -- immunology KW - Streptococcus pneumoniae -- pathogenicity KW - Streptococcus pneumoniae -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72174125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+microbiology&rft.atitle=Virulence%2C+immunity%2C+and+vaccine+related+to+Streptococcus+pneumoniae.&rft.au=Lee%2C+C+J%3BBanks%2C+S+D%3BLi%2C+J+P&rft.aulast=Lee&rft.aufirst=C&rft.date=1991-01-01&rft.volume=18&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+microbiology&rft.issn=1040841X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-16 N1 - Date created - 1991-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Suppression of human immunoglobulin synthesis by interleukin-4 in tandem with interleukin-2 through large granular lymphocytes. AN - 72169950; 1930692 AB - Recent studies have shown that interleukin (IL)-4 can affect secretion of immunoglobulins (Igs) or activation of cytotoxic cells by IL-2, while other studies have shown that natural killer (NK) cells/large granular lymphocytes (LGLs) can also affect Ig synthesis. Therefore, we examined the effect of IL-4 with and without IL-2 or human NK/LGLs on pokeweed mitogen (PWM)-stimulated production of IgM and IgG. We found that when IL-4 and/or IL-2 were incubated with peripheral blood lymphocytes and PWM for 7 days and an enzyme-linked immunosorbent assay was run to measure Ig synthesis, IL-4 with IL-2 caused a greater suppression of Ig synthesis than either cytokine alone. A further experiment was done to determine the effect IL-4 and IL-2 would have on LGL suppression of Ig synthesis. IL-4 and IL-2 alone and in combination, when added to LGL, caused the LGL to suppress Ig synthesis to a greater extent than alone. We conclude that IL-4 acts on NK/LGLs separately and jointly with IL-2, to suppress Ig synthesis (IgM and IgG). JF - Pathobiology : journal of immunopathology, molecular and cellular biology AU - Bosse, D AU - Ades, E AD - Biological Products Branch, Centers for Disease Control, US Department of Health and Human Services, Atlanta, Ga. Y1 - 1991 PY - 1991 DA - 1991 SP - 391 EP - 395 VL - 59 IS - 6 SN - 1015-2008, 1015-2008 KW - Immunoglobulin G KW - 0 KW - Immunoglobulin M KW - Immunoglobulins KW - Interleukin-2 KW - Pokeweed Mitogens KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Immunoglobulin M -- metabolism KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Immunoglobulin G -- metabolism KW - Drug Synergism KW - Interleukin-2 -- pharmacology KW - Immunoglobulins -- metabolism KW - Interleukin-4 -- pharmacology KW - Killer Cells, Natural -- metabolism KW - Killer Cells, Natural -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72169950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathobiology+%3A+journal+of+immunopathology%2C+molecular+and+cellular+biology&rft.atitle=Suppression+of+human+immunoglobulin+synthesis+by+interleukin-4+in+tandem+with+interleukin-2+through+large+granular+lymphocytes.&rft.au=Bosse%2C+D%3BAdes%2C+E&rft.aulast=Bosse&rft.aufirst=D&rft.date=1991-01-01&rft.volume=59&rft.issue=6&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Pathobiology+%3A+journal+of+immunopathology%2C+molecular+and+cellular+biology&rft.issn=10152008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-26 N1 - Date created - 1991-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Compliance issues and proper animal drug use in aquaculture. AN - 72161250; 1926755 JF - Veterinary and human toxicology AU - Mitchell, G A AD - Office of Surveillance and Compliance, FDA/CVM, Rockville, MD 20857. Y1 - 1991 PY - 1991 DA - 1991 SP - 9 EP - 10 VL - 33 Suppl 1 SN - 0145-6296, 0145-6296 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - United States Environmental Protection Agency KW - Fishes KW - Agriculture -- methods KW - Government Agencies -- standards KW - Fisheries KW - Drug Residues KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72161250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Compliance+issues+and+proper+animal+drug+use+in+aquaculture.&rft.au=Mitchell%2C+G+A&rft.aulast=Mitchell&rft.aufirst=G&rft.date=1991-01-01&rft.volume=33+Suppl+1&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulatory and scientific roles for biodistribution studies in aquatic species. AN - 72159037; 1926750 AB - The advantage of focusing on biliary excretion of drugs and other xenobiotics is emphasized in this discussion of the regulatory and scientific roles for biodistribution studies in aquatic species. The role of the hepatobiliary system in the overall disposition of absorbed chemicals is briefly reviewed. The present survey includes 18 drugs, 6 petroleum hydrocarbons, and 16 different fish species. The fact that aquatic species concentrate most xenobiotics and their metabolites into bile to as much as several orders of magnitude underscores the advantage of using bile rather than tissue to determine whether aquatic species are being exposed to given chemicals. Until these advantages are recognized, analysis of edible muscle tissue remains the method of choice for assessment of human exposure to chemicals. JF - Veterinary and human toxicology AU - Guarino, A M AD - Division of Seafood Research, Food and Drug Administration, Dauphin Island, AL 36525. Y1 - 1991 PY - 1991 DA - 1991 SP - 54 EP - 59 VL - 33 Suppl 1 SN - 0145-6296, 0145-6296 KW - Anti-Bacterial Agents KW - 0 KW - Hydrocarbons KW - Petroleum KW - Index Medicus KW - Animals KW - Muscles -- chemistry KW - Tissue Distribution KW - Bile -- chemistry KW - Hydrocarbons -- analysis KW - Drug Residues -- pharmacokinetics KW - Drug Residues -- analysis KW - Anti-Bacterial Agents -- analysis KW - Hydrocarbons -- pharmacokinetics KW - Fishes -- metabolism KW - Bile -- metabolism KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72159037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Regulatory+and+scientific+roles+for+biodistribution+studies+in+aquatic+species.&rft.au=Guarino%2C+A+M&rft.aulast=Guarino&rft.aufirst=A&rft.date=1991-01-01&rft.volume=33+Suppl+1&rft.issue=&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug abuse prevention evaluation methodology: a bright future. AN - 72130121; 1919958 AB - Drug abuse prevention research findings have been inconsistent. These inconsistencies can be related to several issues including study design and methodology. This article presents consensus recommendations developed to enhance drug abuse prevention evaluation research by a group of prevention researchers and practitioners who met at the National Institute on Drug Abuse in Rockville, Maryland during May 1989. As noted by the number of consensus statements, there was a high level of agreement. After exploring various aspects of evaluating prevention interventions, that agreement was reflected in specific recommendations which are directed to modifying prevention approaches; integrating epidemiologic, etiologic and intervention research methods; and expanding prevention research utilization. JF - Journal of drug education AU - Leukefeld, C G AU - Bukoski, W J AD - U.S. Public Health Service, Rockville, Maryland. Y1 - 1991 PY - 1991 DA - 1991 SP - 191 EP - 201 VL - 21 IS - 3 SN - 0047-2379, 0047-2379 KW - Index Medicus KW - Primary Prevention KW - Public Health -- methods KW - Humans KW - Research Design KW - Program Evaluation -- trends KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72130121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+drug+education&rft.atitle=Drug+abuse+prevention+evaluation+methodology%3A+a+bright+future.&rft.au=Leukefeld%2C+C+G%3BBukoski%2C+W+J&rft.aulast=Leukefeld&rft.aufirst=C&rft.date=1991-01-01&rft.volume=21&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+drug+education&rft.issn=00472379&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-06 N1 - Date created - 1991-11-06 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Confirmation of trace level residues in the food supply. AN - 72116410; 1910522 AB - With the recent proliferation of mass spectrometric methods available for the identification and confirmation of various compounds in different environmental matrices, it is timely to address the criteria desirable in a regulatory sample case. The emphasis of this review is on the experimental process of confirmation at concentration levels in the range of low parts per million (ppm) to parts per trillion (ppt). At such levels, various data manipulations or alternate choices of approaching the analytical problem of confirmation must be employed to ensure an acceptable result. The problems experienced when dealing with nanogram levels in analysis are much more complex than when recording a mass spectrum of an ample supply of a reference standard. This review reflects an interpretation of the developing status of confirmation since there does not yet exist "accepted criteria". JF - Critical reviews in food science and nutrition AU - Cairns, T AU - Siegmund, E G AD - Department of Health and Human Services, Food and Drug Administration Los Angeles, California. Y1 - 1991 PY - 1991 DA - 1991 SP - 397 EP - 402 VL - 30 IS - 4 SN - 1040-8398, 1040-8398 KW - Trace Elements KW - 0 KW - Index Medicus KW - Mass Spectrometry KW - Food Analysis -- standards KW - Drug Residues -- analysis KW - Trace Elements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72116410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+food+science+and+nutrition&rft.atitle=Confirmation+of+trace+level+residues+in+the+food+supply.&rft.au=Cairns%2C+T%3BSiegmund%2C+E+G&rft.aulast=Cairns&rft.aufirst=T&rft.date=1991-01-01&rft.volume=30&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+food+science+and+nutrition&rft.issn=10408398&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anti-nutritive effects of dietary tin. AN - 72110021; 1897407 AB - Tin is usually present in foods at levels of less than 4 micrograms/g. Higher levels may be found in some processed foods due to the addition of tin-based preservatives and stabilizers or to corrosion and leaching of the metal from unlacquered cans or from tin foils used in packaging. Estimates of dietary intake range from about 0.2 to greater than 5 mg Sn/day. Diets including a high proportion of canned vegetables and fish could supply greater than 30 mg Sn/day. Although intakes from dietary sources are generally considered to be harmless, a variety of adverse effects of tin have been reported, including effects on serum and bone alkaline phosphatase, lactic dehydrogenase, heme oxygenase, and 5-aminolevulinic acid dehydratase. Perturbations in glutathione metabolism have been reported, as have adverse effects on metabolism of essential trace minerals such as copper, zinc, and iron. Specific effects on calcium content of bone, serum, and kidney have also been described. Reported effects vary with the chemical form, dose of tin, and route and frequency of administration. Effects of tin in animal systems and on essential trace mineral absorption and excretion in human volunteers are reviewed. A summary of recent investigations on dietary tin-copper interactions and effects of tin on rat hepatocellular antioxidant protection are also presented. JF - Advances in experimental medicine and biology AU - Rader, J I AD - Division of Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 509 EP - 524 VL - 289 SN - 0065-2598, 0065-2598 KW - Manganese KW - 42Z2K6ZL8P KW - Tin KW - 7440-31-5 KW - Copper KW - 789U1901C5 KW - Iron KW - E1UOL152H7 KW - Zinc KW - J41CSQ7QDS KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Eating -- drug effects KW - Weight Gain -- drug effects KW - Animals KW - Duodenum -- chemistry KW - Iron -- analysis KW - Manganese -- analysis KW - Dose-Response Relationship, Drug KW - Calcium -- analysis KW - Food Handling KW - Kidney -- chemistry KW - Liver -- chemistry KW - Food Preservation KW - Rats KW - Zinc -- analysis KW - Femur -- chemistry KW - Copper -- analysis KW - Male KW - Tin -- adverse effects KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72110021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Anti-nutritive+effects+of+dietary+tin.&rft.au=Rader%2C+J+I&rft.aulast=Rader&rft.aufirst=J&rft.date=1991-01-01&rft.volume=289&rft.issue=&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-24 N1 - Date created - 1991-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Residue trypsin inhibitor: data needs for risk assessment. AN - 72106329; 1897396 AB - Trypsin inhibitor (TI) occurs naturally in many foods from plants, notably soybean protein products. Heat treatment inactivates TI and improves nutritional quality, but residual TI activity of 5 to 20% remains after typical commercial treatments. Chronic feeding of TI or products that contain TI can inhibit trypsin and chymotrypsin, stimulate their secretion, cause hypertrophy and hyperplasia of the pancreas, and lead to adenomas and carcinomas of the exocrine pancreas. In the rat, TI promotes pancreatic carcinogenesis initiated by azaserine. Data needed for possible risk assessment on TI would include 2-year bioassays from animals treated with TI and fed diets carefully controlled for type and amount of fat (which also promotes pancreatic carcinogenesis). The effects of TI on protein nutrition would have to be considered when identifying the maximum tolerated dose. Major reductions in human dietary TI exposure may not be feasible because of the multiple sources of TI, the substantial promotion by other factors such as fat, and the adverse effects of excessive heat on food products. For risk assessment of TI in a particular food, other promotors and the feasibility of decreasing TI intake must be considered. JF - Advances in experimental medicine and biology AU - Hathcock, J N AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 273 EP - 279 VL - 289 SN - 0065-2598, 0065-2598 KW - Trypsin Inhibitors KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Pancreas -- drug effects KW - Trypsin Inhibitors -- toxicity KW - Soybeans -- toxicity KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72106329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Residue+trypsin+inhibitor%3A+data+needs+for+risk+assessment.&rft.au=Hathcock%2C+J+N&rft.aulast=Hathcock&rft.aufirst=J&rft.date=1991-01-01&rft.volume=289&rft.issue=&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-24 N1 - Date created - 1991-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The use of uninduced rat liver S-9 to supplement BALB/3T3 cells in the in vitro transformation assay. AN - 72088947; 1889371 AB - Because of limited inherent capacity to metabolize chemicals to their reactive form, the BALB/3T3 transformation assay using clone A31-1-1 cells requires metabolic supplementation with rodent liver homogenate preparations (S-9). Activation by S-9 is limited, however, by its cytotoxicity to the cells, thus necessitating a reduction in treatment time from the usual 24-72 to 1-4 hr. With cyclophosphamide (CP) as a test chemical, we were able to increase the treatment time to 24 hr by using lower concentrations of cofactors and S-9 prepared from the livers of untreated rats. Statistically significant increases in transformed foci were induced in cultures treated with 50 or 100 micrograms CP/ml in the presence of 100 or 200 micrograms of uninduced rat liver S-9/ml and 76 or 380 micrograms each of NADH, NADP, NADPH, and glucose-6-phosphate per ml of incubation medium. JF - Drug and chemical toxicology AU - Sheu, C J AU - Lee, J K AU - Rodriguez, I AU - Randolph, S C AD - Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 113 EP - 126 VL - 14 IS - 1-2 SN - 0148-0545, 0148-0545 KW - Carcinogens KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cells, Cultured KW - Biotransformation KW - Cyclophosphamide -- metabolism KW - Cyclophosphamide -- toxicity KW - Male KW - Carcinogens -- metabolism KW - Microsomes, Liver -- metabolism KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72088947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=The+use+of+uninduced+rat+liver+S-9+to+supplement+BALB%2F3T3+cells+in+the+in+vitro+transformation+assay.&rft.au=Sheu%2C+C+J%3BLee%2C+J+K%3BRodriguez%2C+I%3BRandolph%2C+S+C&rft.aulast=Sheu&rft.aufirst=C&rft.date=1991-01-01&rft.volume=14&rft.issue=1-2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-15 N1 - Date created - 1991-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hydroxylation and deglycosylation of 2'-deoxyguanosine in the presence of magnesium and nickel. AN - 72070070; 1884431 AB - Nickel (Ni), a carcinogenic and genotoxic metal, has been shown to enhance deglycosylation and hydroxylation of 2'-deoxyguanosine (dG) that has been caused by ascorbic acid and H2O2. There is evidence that Mg is a competitive antagonist of the toxicological effects of Ni. A factorial design was used to examine the interactive influence of Mg and Ni on the deglycosylation and hydroxylation of dG under a range of pH conditions in which ascorbate (Ascb) and H2O2 were added. Formation of guanine (Gu) (deglycosylation) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG) (hydroxylation) appeared in large amounts in samples in which both H2O2 and Ascb were present. The largest amounts of Gu appeared where both Ni or magnesium (Mg) were present. When Mg alone was present, the amounts of Gu was intermediate between these two. Slightly less 8-OH-dG was formed where only Mg was present. The reaction mixtures were more sensitive to the pH than to the respective presence or absence of metals. At slightly acid or neutral pH (6.2-7.0) large amounts of both Gu and 8-OH-dG were formed. Gu formation decreased dramatically between pH 7.0 and 7.2. There was no 8-OH-dG formed at pH 7.8 and only small amounts at pH 7.6. The formation of 8-OH-dG was generally less where Mg was present. When Ni was absent, 8-OH-dG formation was greater in the pH 6.8 mixtures. The formation of Gu and 8-OH-dG from 2'-deoxyguanosine are directly a function of pH. Slight changes in pH greatly effected the formation of these biomarkers of oxidatively damaged DNA. Additional research is needed to determine if this is a cause or effect, i.e. does pH enhance toxicity conditions, thus permitting formation of 8-OH-dG, or does pH permit the reaction to proceed. JF - Chemico-biological interactions AU - Littlefield, N A AU - Fullerton, F R AU - Poirier, L A AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 217 EP - 228 VL - 79 IS - 2 SN - 0009-2797, 0009-2797 KW - Nickel KW - 7OV03QG267 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Deoxyguanosine KW - G9481N71RO KW - Magnesium KW - I38ZP9992A KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Hydrogen Peroxide -- toxicity KW - Glycosylation -- drug effects KW - Biotransformation KW - Hydrogen-Ion Concentration KW - Hydroxylation -- drug effects KW - Ascorbic Acid -- toxicity KW - Deoxyguanosine -- metabolism KW - Deoxyguanosine -- pharmacokinetics KW - Magnesium -- toxicity KW - Nickel -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72070070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Hydroxylation+and+deglycosylation+of+2%27-deoxyguanosine+in+the+presence+of+magnesium+and+nickel.&rft.au=Littlefield%2C+N+A%3BFullerton%2C+F+R%3BPoirier%2C+L+A&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1991-01-01&rft.volume=79&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-09 N1 - Date created - 1991-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational sentinel health events: an up-dated list for physician recognition and public health surveillance. AN - 72067849; 1882855 AB - An occupational sentinel health event (SHE[O]) is a disease, disability, or untimely death, which is occupationally related and whose occurrence may: 1) provide the impetus for epidemiologic or industrial hygiene studies; or 2) serve as a warning signal that materials substitution, engineering control, personal protection, or medical care may be required. Following survey of scientific literature, a list of 50 disease conditions linked to the workplace was presented in 1983; these were codable within the framework of the International Classification of Diseases system (ICD-9). Three criteria were used for inclusion: documentation of associated agent(s), of involved industries, and of involved occupations. The up-dated list contains 64 diseases or conditions and a bibliography of literature citations. The list is useful for the practicing physician in occupational disease recognition, for occupational morbidity and mortality surveillance, and as a periodically up-dated database of occupationally related diseases. JF - American journal of industrial medicine AU - Mullan, R J AU - Murthy, L I AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 775 EP - 799 VL - 19 IS - 6 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Occupational Health KW - Information Systems KW - Quality of Health Care KW - Humans KW - United States -- epidemiology KW - Morbidity KW - Population Surveillance KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72067849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Occupational+sentinel+health+events%3A+an+up-dated+list+for+physician+recognition+and+public+health+surveillance.&rft.au=Mullan%2C+R+J%3BMurthy%2C+L+I&rft.aulast=Mullan&rft.aufirst=R&rft.date=1991-01-01&rft.volume=19&rft.issue=6&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-01 N1 - Date created - 1991-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Flow cytometric evaluation of cell-cycle progression in ethyl methanesulfonate and methyl methanesulfonate-exposed P3 cells: relationship to the induction of sister-chromatid exchanges and cellular toxicity. AN - 72058412; 1879406 AB - In order to determine the relationships among the reduction in relative cloning efficiency (RCE), sister-chromatid exchange (SCE) formation, and interference with progression through the cell-cycle, human teratocarcinoma-derived (P3) cells were exposed to either ethyl methanesulfonate or to methyl methanesulfonate. The relationship between SCE and toxicity was quantified, the progression through the cell-cycle was evaluated with flow cytometric methods, and the effects of these chemicals on cell growth and average generation time (AGT) were determined. A strong correlation existed between RCE and SCE (r = -0.978, p less than .001) which was accompanied by an inhibition of growth as evidenced by a significant (p less than .0001) negative linear effect of concentration on the relative cell count from 24 to 72 hours after exposure and by a concentration-dependent increase (p less than .0001) in the AGT. Delays in the transit through S-phase were evident 4 hours after exposure to toxic concentrations of either carcinogen and by 8 to 12 hours post-exposure at the lower concentrations. Increases in the percentage of nuclei in G2 + M, indicative of G2 arrest, occurred from 12 to 24 hours after exposure. One interpretation of these results is that those effects of EMS and MMS exposure which result in S-phase delay and G2 arrest may be those elements common to the induction of SCE and cellular toxicity. JF - Environmental and molecular mutagenesis AU - Morris, S M AU - Domon, O E AU - McGarrity, L J AU - Kodell, R L AU - Casciano, D A AD - Division of Genetic Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 139 EP - 149 VL - 18 IS - 2 SN - 0893-6692, 0893-6692 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Index Medicus KW - Tumor Cells, Cultured KW - Dose-Response Relationship, Drug KW - Humans KW - In Vitro Techniques KW - Flow Cytometry KW - Time Factors KW - Teratoma KW - Methyl Methanesulfonate -- toxicity KW - Sister Chromatid Exchange KW - Ethyl Methanesulfonate -- toxicity KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72058412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Flow+cytometric+evaluation+of+cell-cycle+progression+in+ethyl+methanesulfonate+and+methyl+methanesulfonate-exposed+P3+cells%3A+relationship+to+the+induction+of+sister-chromatid+exchanges+and+cellular+toxicity.&rft.au=Morris%2C+S+M%3BDomon%2C+O+E%3BMcGarrity%2C+L+J%3BKodell%2C+R+L%3BCasciano%2C+D+A&rft.aulast=Morris&rft.aufirst=S&rft.date=1991-01-01&rft.volume=18&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-01 N1 - Date created - 1991-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Mass Media and Health: Opportunities for Improving the Nation's Health. A Report to the Office of Disease Prevention and Health Promotion and Office for Substance Abuse Prevention. Monograph Series. AN - 62908689; ED346886 AB - Several interested organizations and agencies completed an exploration of the complexities and challenges affecting the communication of health information through the mass media. The goal of this effort was to create a shared agenda for increasing cooperation between mass media and public health professionals in addressing the issues, problems, and challenges of communicating health information to the public. The process included convening a group of experts to identify the issues; commissioning a series of papers to explore the issues; and bringing together public health and mass media representatives to identify barriers to collaboration and opportunities for working together to improve the quality and quantity of health coverage through the media. The objectives of this project included: (1) increasing understanding of the influences of mass communications on health issues and problems; (2) exploring shared responsibilities among media and public health professionals; (3) designing strategies for influencing policymakers and gatekeepers in the mass media and public health fields; and (4) setting priorities within both sectors for future discussion and exploration. This report summarizes the issues explored and presents a series of strategies for increasing cooperation between mass media and the public health community. Recommendations are presented for marketing communications, news, entertainment, the public health response to media interests and needs, the media response to public health needs, and policies and regulations affecting health communications. Appended materials include lists of program sponsors and contributors to the program as well as a list of eight papers commissioned for the project. (BBM) Y1 - 1991 PY - 1991 DA - 1991 SP - 68 KW - Health Information KW - ERIC, Resources in Education (RIE) KW - Substance Abuse KW - Information Dissemination KW - Advertising KW - Health Education KW - News Reporting KW - Mass Media Role KW - Disease Control KW - Mass Media Effects KW - Public Health KW - Broadcast Journalism KW - Programing (Broadcast) KW - Federal Regulation KW - Change Strategies KW - Change Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62908689?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Policy Report of the Physician Consortium on Substance Abuse Education. AN - 62829582; ED350944 AB - This report contains the recommendations of the Physician Consortium for significantly improving medical education and training to enhance the physician's role in early identification, treatment, and prevention of substance abuse. In addition, the consortium subcommittees report on their examination of substance abuse treatment needs of ethnic and racial minority groups and on the unique training needs that are especially germane to the care of adolescents and children. Recommendations address the need for changes in undergraduate medical education, graduate medical education, and continuing medical education; they also focus special attention on the concerns of adolescents and children and the multicultural issues in substance abuse education and training of physicians. The report concludes with background information on the problems of substance abuse in general and on certain specific substances--cocaine, marijuana, alcohol and tobacco products--in particular. Contains 32 references. (GLR) AU - Lewis, David C. AU - Faggett, Walter L. Y1 - 1991 PY - 1991 DA - 1991 SP - 38 VL - HRSA-P-DM-91-3 KW - Primary Prevention KW - ERIC, Resources in Education (RIE) KW - Policymakers KW - Health Programs KW - Substance Abuse KW - Undergraduate Study KW - Higher Education KW - National Surveys KW - Educational Needs KW - Children KW - Medical Education KW - Health Promotion KW - Alcohol Abuse KW - Minority Groups KW - Ethnic Groups KW - Continuing Education KW - Professional Education KW - Graduate Medical Education KW - Physicians KW - Adolescents KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62829582?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Abuse, Neglect, and the HIV-Infected Child AN - 61633861; 199101178 AB - The effects of HIV (human immunodeficiency virus) on child abuse prevention are considered on two levels: indirect, ie, the demands made on medical & social services due to the disease may lead to decreasing resources for child abuse prevention, & direct, ie, the actual abuse & neglect of HIV-infected children. The overall prevalence of the disease is estimated using 1986 data, noting the lack of accurate data on infection rates in infants & children. Four major HIV-related issues that have direct child abuse or neglect implications are discussed: ostracism & school attendance, hospitalization of the infected child, non-hospital care/foster placement of the infected child, & HIV-antibody screening of the sexually abused child. 9 Tables, 2 Figures, 2 References. S. Dilts JF - Child Abuse and Neglect AU - Jason, Janine M AD - Public Health Service Centers Disease Control, 1600 Clifton Rd Atlanta GA 30333 Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 79 EP - 88 VL - 15 SN - 0145-2134, 0145-2134 KW - child abuse prevention, human immunodeficiency virus-infected children KW - Prevention KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Children KW - Child Abuse KW - article KW - 6143: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61633861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+and+Neglect&rft.atitle=Abuse%2C+Neglect%2C+and+the+HIV-Infected+Child&rft.au=Jason%2C+Janine+M&rft.aulast=Jason&rft.aufirst=Janine&rft.date=1991-01-01&rft.volume=15&rft.issue=&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+and+Neglect&rft.issn=01452134&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child Abuse; Prevention; Acquired Immune Deficiency Syndrome; Children; Intervention ER - TY - BOOK T1 - Locating resources for Healthy People 2000 health promotion projects AN - 59591749; 1992-0406015 AB - Sources of funds and other support for health promotion projects available through private organizations and public agencies. JF - Supt Docs, 1991. 46+10 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - 46+10 PB - Supt Docs SN - 0160359287 KW - Government loans and grants -- United States KW - Community funds -- United States KW - Public health -- United States KW - Medicine, Preventive -- United States KW - Public health education -- United States KW - Philanthropy -- United States KW - United States -- Health policy KW - Community health services -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59591749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=46%2B10&rft.isbn=0160359287&rft.btitle=Locating+resources+for+Healthy+People+2000+health+promotion+projects&rft.title=Locating+resources+for+Healthy+People+2000+health+promotion+projects&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Supt Docs (ISBN 0-16-035928-7) pa U.S. $3.25; elsewhere $4.06 N1 - Document feature - bibl(s), il(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Health status of minorities and low-income groups AN - 59583075; 1992-0204512 AB - Documents disparity between the general and the disadvantaged population. Prevention, mental, dental, and reproductive health, chronic and acute diseases, injuries, HIV/AIDS, old age, utilization of services, and insurance and expenditures. JF - Supt Docs, 1991. iii+376 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - iii+376 PB - Supt Docs SN - 016030573X KW - Minorities -- Health -- Statistics KW - United States -- Social conditions KW - Poor -- Health -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59583075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=iii%2B376&rft.isbn=016030573X&rft.btitle=Health+status+of+minorities+and+low-income+groups&rft.title=Health+status+of+minorities+and+low-income+groups&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Supt Docs (ISBN 0-16-030573-X) pa U.S. $18; elsewhere $22.50 N1 - Document feature - table(s), chart(s) N1 - SuppNotes - 3d ed N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Healthy children 2000: national health promotion and disease prevention objectives related to mothers, infants, children, adolescents, and youth T2 - Dept. of Health and Human Services. DHHS pubn. no. HRSA-M-CH 91-2 AN - 59579151; 1992-0200994 AB - Adapted from "Healthy people 2000," indexed in the 1991 PAIS International in Print. JF - Washington, DC 20201, 1991. 244 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 244 PB - Washington, DC 20201 KW - Maternal and infant welfare -- United States KW - Child health -- United States KW - Public health -- United States KW - Medicine, Preventive -- United States KW - Health planning -- United States KW - United States -- Health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59579151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=Adrian&rft.date=2015-06-24&rft.volume=401&rft.issue=60&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Aviation+Daily&rft.issn=01934597&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20201 pa N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Nursing home reform and the mentally ill T2 - Nat. Med. Expenditure Survey AHCPR pubn. no. 91-0010 AN - 59575189; 1991-0913688 AB - Implications of the Medicaid reforms of the 1987 Omnibus Budget Reconciliation Act; estimates the number of mentally ill residents who might be displaced by the review and screening process. Also printed in Health Affairs 9:47-60 Winter '90. JF - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, 1991. 47-60 pp. AU - Freiman, Marc P Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 14 EP - 60 PB - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - Medicaid program -- United States KW - Mentally ill -- Care and treatment KW - Mentally ill -- United States KW - Nursing homes -- United States KW - United States -- Social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59575189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Freiman%2C+Marc+P&rft.aulast=Freiman&rft.aufirst=Marc&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=Nursing+home+reform+and+the+mentally+ill&rft.title=Nursing+home+reform+and+the+mentally+ill&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 N1 - Document feature - table(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Injury mortality atlas of the United States, 1979-1987 AN - 59574666; 1991-1510077 AB - Organized by type of injury, including homicide and suicide, state, and county. Prepared by the Centers for Disease Control and other agencies. JF - Atlanta, GA 30333, 1991. ii+141 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - ii+141 PB - Atlanta, GA 30333 KW - Personal injuries -- United States -- Statistics KW - Homicide -- United States -- Statistics KW - Suicide -- United States -- Statistics KW - United States -- Demographics KW - Accidents -- United States -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59574666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=ii%2B141&rft.isbn=&rft.btitle=Injury+mortality+atlas+of+the+United+States%2C+1979-1987&rft.title=Injury+mortality+atlas+of+the+United+States%2C+1979-1987&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Atlanta, GA 30333 (22x28 cm) spiral bdg N1 - Document feature - bibl(s), table(s), chart(s), map(s) N1 - SuppNotes - leaves N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Trends in Indian health, 1991 AN - 59573206; 1992-0110828 AB - Structure of the IHS and health status of American Indians and Alaska natives. Includes birth, mortality, patient care, and community health statistics. JF - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane Rockville, MD 20857, 1991. vi+93 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - vi+93 PB - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane Rockville, MD 20857 KW - Alaska -- Native races -- Health KW - Indians -- Health -- Statistics KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59573206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=vi%2B93&rft.isbn=&rft.btitle=Trends+in+Indian+health%2C+1991&rft.title=Trends+in+Indian+health%2C+1991&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane Rockville, MD 20857 pa N1 - Document feature - table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Statistical evaluation and time series analysis of microseismicity, mining, and rock bursts in a hard-rock mine AN - 51273669; 2008-042178 AB - Quantifying relationships between microseismicity and mining geometry and stress. JF - Report of Investigations - United States. Bureau of Mines AU - Riefenberg, J Y1 - 1991 PY - 1991 DA - 1991 SP - 15 PB - U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Washington, D.C. SN - 1066-5552, 1066-5552 KW - deep mining KW - rock bursts KW - statistical analysis KW - microseisms KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51273669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Riefenberg%2C+J&rft.aulast=Riefenberg&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Statistical+evaluation+and+time+series+analysis+of+microseismicity%2C+mining%2C+and+rock+bursts+in+a+hard-rock+mine&rft.title=Statistical+evaluation+and+time+series+analysis+of+microseismicity%2C+mining%2C+and+rock+bursts+in+a+hard-rock+mine&rft.issn=10665552&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from the AESIS Database supplied under licence from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2008-01-01 N1 - Number of references - 43 N1 - PubXState - D.C. N1 - Document feature - illus. incl. 4 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - deep mining; microseisms; rock bursts; statistical analysis ER - TY - JOUR T1 - Technological developments with the FDA adverse drug reaction file system AN - 16748986; 3520643 AB - A review of the Food and Drug Administration (FDA) Adverse Drug Reaction (ADR) file system. This paper describes the current operations for maintaining the on-line computerized data entry, storage and retrieval programs, and the microfilm retrieval system. Other technology developments discussed include data diskette exchange and laser disc storage and retrieval. JF - Drug Information Journal AU - Gelberg, A AU - Armstrong, G D AU - Dreis, M W AU - Anello, C AD - HFD-737, Cent. Drug Eval. and Res., FDA, 5600 Fishers La., Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 19 EP - 28 VL - 25 IS - 1 SN - 0092-8615, 0092-8615 KW - FDA KW - Toxicology Abstracts KW - side effects KW - data collections KW - pharmaceuticals KW - X 24230:Legislation & recommended standards KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16748986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Technological+developments+with+the+FDA+adverse+drug+reaction+file+system&rft.au=Gelberg%2C+A%3BArmstrong%2C+G+D%3BDreis%2C+M+W%3BAnello%2C+C&rft.aulast=Gelberg&rft.aufirst=A&rft.date=1991-01-01&rft.volume=25&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - pharmaceuticals; side effects; data collections ER - TY - JOUR T1 - Access, science, and regulation AN - 16742621; 3520644 AB - There is a potential tension between the desirable goals of assuring early availability of promising agents for treatment of serious illnesses without adequate therapy and developing such agents in a rigorous way that will yield scientifically valid answers about their safety and effectiveness. Because the two goals are linked to fundamental principles and values, it is possible for people who feel strongly about one of them to ignore the importance of the other. But it is neither necessary nor desirable to choose one goal exclusively; Early access is reasonable on both ethical and medical grounds and can be provided, with care and planning, without degrading the quality of evidence we develop to support new agents. A clear picture of the effectiveness and safety of a drug, and information on how best to use it is most critical, not to academics and regulators, but to the patients whose lives and health may depend on the drug, and obtaining this information does not require that access be denied until it is all in hand. JF - Drug Information Journal AU - Temple, R J AD - Off. Drug Eval. 1, FDA, HFD 100, 5600 Fishers La., Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1 EP - 11 VL - 25 IS - 1 SN - 0092-8615, 0092-8615 KW - Toxicology Abstracts KW - safety KW - research programs KW - pharmaceuticals KW - evaluation KW - X 24230:Legislation & recommended standards KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16742621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Access%2C+science%2C+and+regulation&rft.au=Temple%2C+R+J&rft.aulast=Temple&rft.aufirst=R&rft.date=1991-01-01&rft.volume=25&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - pharmaceuticals; safety; evaluation; research programs ER - TY - BOOK T1 - Natural toxins [in seafoods] AN - 16735294; 3718519 AB - Natural toxins in seafoods present many challenges, many of which have yet to be satisfactorily addressed. The development and implementation of appropriate measures is and will remain expensive. But the payoff is great, and more than justifies the investment. Seafood can be a wholesome, enjoyable, and affordable source of nutrition and will find an eager marker if quality and safety are assured. JF - VAN ROSTRAND REINHOLD, NEW YORK (USA). pp. 301-330. 1991. AU - Hall, S Y1 - 1991 PY - 1991 DA - 1991 SP - 30 EP - 330 PB - VAN ROSTRAND REINHOLD, NEW YORK (USA) SN - 0442233469 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - biological poisons KW - seafood KW - quality control KW - food poisoning KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16735294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hall%2C+S&rft.aulast=Hall&rft.aufirst=S&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=301&rft.isbn=0442233469&rft.btitle=Natural+toxins&rft.title=Natural+toxins&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Includes bibliogr: 117 ref. N1 - Last updated - 2014-05-06 ER - TY - JOUR T1 - The raw oyster consumer -- A risk taker? Use of the behavioral risk factor surveillance system AN - 16734738; 3518690 AB - 1988 Behavioral Risk Factor Surveillance System in Florida was used to determine the prevalence of consumption of raw oysters, a vehicle implicated in the transmission of several pathogens. One-third of survey respondents reported ever eating raw oysters. The prevalence was higher for persons 18-49 years old and for males, and, when controlled for age and sex, for persons who reported being cigarette smokers or acute or chronic alcohol drinkers, and driving while intoxicated. JF - Epidemiology AU - Klontz, K C AU - Desenclos, JCA AU - Wolfe, LE AU - Hoecherl, SA AU - Roberts, C AU - Gunn, R A AD - Clin. Nutr. Br., Cent. Food Saf. and Appl. Nutr., FDA, Washington, DC, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 437 EP - 440 VL - 2 IS - 6 SN - 1044-3983, 1044-3983 KW - raw oysters KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine KW - pathogenic bacteria KW - seafood KW - hazard assessment KW - human food KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16734738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology&rft.atitle=The+raw+oyster+consumer+--+A+risk+taker%3F+Use+of+the+behavioral+risk+factor+surveillance+system&rft.au=Klontz%2C+K+C%3BDesenclos%2C+JCA%3BWolfe%2C+LE%3BHoecherl%2C+SA%3BRoberts%2C+C%3BGunn%2C+R+A&rft.aulast=Klontz&rft.aufirst=K&rft.date=1991-01-01&rft.volume=2&rft.issue=6&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Epidemiology&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - pathogenic bacteria; seafood; human food; hazard assessment; public health; Marine ER - TY - BOOK T1 - Non-indigenous bacterial pathogens AN - 16733613; 3718562 AB - An account is given of bacterial pathogens which, although often present in seafood, are not common to the marine environment. These pathogens are rather the result of direct fecal transmission from human or animal reservoir or a result of poor general sanitation. The first category of risk includes species of fish eaten raw (sushi) and other aquatic food animals such as molluscs. The second category results from insanitary practices during fish product handling. The following species are discussed: Clostridium botulinum, Listeria monocytogenes, Staphylococcus aureus, Salmonella and Shigella. It is concluded that food sanitation and quality control measures that consider the safety of seafood from harvest to consumption must be developed in the future to ensure a continued high level of safety. JF - VAN ROSTRAND REINHOLD, NEW YORK (USA). pp. 267-284. 1991. AU - Kvenberg, JE Y1 - 1991 PY - 1991 DA - 1991 SP - 18 EP - 284 PB - VAN ROSTRAND REINHOLD, NEW YORK (USA) SN - 0442233469 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Listeria monocytogenes KW - pathogenic bacteria KW - microbial contamination KW - seafood KW - quality control KW - Shigella KW - Clostridium botulinum KW - Staphylococcus aureus KW - Salmonella KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16733613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kvenberg%2C+JE&rft.aulast=Kvenberg&rft.aufirst=JE&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=267&rft.isbn=0442233469&rft.btitle=Non-indigenous+bacterial+pathogens&rft.title=Non-indigenous+bacterial+pathogens&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 ER - TY - JOUR T1 - Evaluating posture behavior during seated tasks AN - 16726548; 3516390 AB - A method was developed to evaluate posture behavior of the trunk, neck, eye, and upper extremity in three-dimensional space during the performance of static, seated tasks. Body postures were measured using an ultrasonic measurement system to determine the Cartesian coordinates of joints and the angles between adjacent limbs. Posture preferences for a variety of visual and manual tasks were then determined. Pilot studies using three subjects performing visual and right-handed tasks showed that the postures were affected by target location, body size, and target size. These experiments suggest that the preferred horizontal location of visual targets is within 10 degree of the sagittal plane of the head. The preferred vertical location of visual targets is 10 degree to 35 degree below the seated eye height. For manual reaches, the target-to-shoulder distance should be at least one-third the length of the upper extremity to avoid extreme elbow flexion. In addition, the seat pan should swivel and should allow a person to move fore and aft in order to adjust to a comfortable work posture. JF - International Journal of Industrial Ergonomics AU - Hsiao, H AU - Keyserling, WM AD - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 313 EP - 334 VL - 8 IS - 4 SN - 0169-8141, 0169-8141 KW - posture KW - Health & Safety Science Abstracts KW - behavior KW - measuring methods KW - ergonomics KW - ultrasonics KW - H SI0.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16726548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Evaluating+posture+behavior+during+seated+tasks&rft.au=Hsiao%2C+H%3BKeyserling%2C+WM&rft.aulast=Hsiao&rft.aufirst=H&rft.date=1991-01-01&rft.volume=8&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ergonomics; behavior; ultrasonics; measuring methods ER - TY - JOUR T1 - A longitudinal study of pulmonary function in fire fighters AN - 16718753; 3510120 AB - Pulmonary function changes among fire fighters were evaluated by re-examining 632 Baltimore city fire fighters six to ten years after a baseline examination. Spirometry was used to determine forced expiratory volume in 1 second (FEV sub(1)). Information about exposures was obtained by questionnaire and by combining data from fire department records regarding the number of fires fought by fire fighting units with individual work histories. Men who never wore a mask while extinguishing fires experienced a 1.7 times greater rate of FEV sub(1) decline than mask wearers. Men with ammonia exposure experienced a rate of decline 1.7 times greater than non-exposed men. Neither length of time spent in exposed jobs nor number of responses were associated with the rate of decline. Active fire fighters experienced a rate of decline 2.5 times greater than those who had retired or resigned. Some effects differed between men who were able to perform repeatable pulmonary function tests and those who were not. JF - American Journal of Industrial Medicine AU - Tepper, A AU - Comstock, G W AU - Levine, M AD - NIOSH, R-18, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 307 EP - 316 VL - 20 IS - 3 SN - 0271-3586, 0271-3586 KW - firefighter services KW - occupational health KW - occupational hazards KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - respiratory system KW - ammonia KW - protective clothing KW - fires KW - lung KW - respiratory function KW - X 24240:Miscellaneous KW - H SE8.28:FIREFIGHTER SERVICES AND SAFETY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16718753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+longitudinal+study+of+pulmonary+function+in+fire+fighters&rft.au=Tepper%2C+A%3BComstock%2C+G+W%3BLevine%2C+M&rft.aulast=Tepper&rft.aufirst=A&rft.date=1991-01-01&rft.volume=20&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ammonia; occupational health; respiratory system; protective clothing; lung; respiratory function; fires; occupational hazards ER - TY - JOUR T1 - The insulin A and B chains contain sufficient structural information to form the native molecule. AN - 16701710; 2982284 AB - Refolding studies show that native insulin can be reformed from A and B chains only. This suggests that the A and B chains contain the necessary structural information and that the C peptide is not required for this process. JF - Trends in Biochemical Sciences AU - Wang, Chih-Chen AU - Tsou, Chen-Lu AD - Div. Biochem. and Biophys., Cent. Biol., Eval. and Res., FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 279 EP - 281 VL - 16 IS - 8 SN - 0968-0004, 0968-0004 KW - A chains KW - B chains KW - C peptide KW - folding KW - insulin KW - requirements KW - reviews KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16701710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biochemical+Sciences&rft.atitle=The+insulin+A+and+B+chains+contain+sufficient+structural+information+to+form+the+native+molecule.&rft.au=Wang%2C+Chih-Chen%3BTsou%2C+Chen-Lu&rft.aulast=Wang&rft.aufirst=Chih-Chen&rft.date=1991-01-01&rft.volume=16&rft.issue=8&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biochemical+Sciences&rft.issn=09680004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 ER - TY - CONF T1 - Food and Drug Administration and National Marine Fisheries Service joint seafood initiative: Status. AN - 16662362; 3018710 AB - Seafood safety is regulated at the Federal level primarily by the U.S. Food and Drug Administration (FDA) which operates a comprehensive, mandatory program under the authorities of the Federal Food Drug and Cosmetic Act and the Public Health Service Act. In addition to this mandatory program, the states operate mandatory seafood regulatory programs designed to meet their regional needs. The National Marine Fisheries Service (NMFS) operates a voluntary, fee-for-service inspection program under the authorities of the Agricultural Marketing Act of 1946 and the Fish and Wildlife Act of 1956. A Memorandum of Understanding (MOU) exists between FDA and NMFS relating to this program. Under that MOU, NMFS ensures that industry participant's operations and products meet the requirements of the FD & C Act, as well as NMFS quality and identity requirements. In 1991 FDA and NOAA/NMFS began the design of a new, jointly operated inspection program and enlisted the cooperation of the seafood industry to the extent that industry trade groups and individuals would participate. This joint program is based on the principles of the Hazard Analysis Critical Control Point system of food inspection. This system requires the industry to develop and maintain records of control points in their process that have been determined critical for the control of product safety, plant/food hygiene, and economic fraud hazards associated with the particular product. Industry and government then become partners in the business of food inspection. JF - REP. FLA. SEA GRANT PROGRAM. pp. 15-17. 1991. AU - Hoskin, G P AU - Wilson, SE Y1 - 1991 PY - 1991 DA - 1991 SP - 15 EP - 17 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - FLSGP-W-90-001 KW - Marine KW - fishery products KW - microbial contamination KW - organizations KW - surveillance and enforcement KW - legislation KW - inspection KW - health and safety KW - joint ventures KW - seafood KW - quality control KW - safety regulations KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16662362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Food+and+Drug+Administration+and+National+Marine+Fisheries+Service+joint+seafood+initiative%3A+Status.&rft.au=Hoskin%2C+G+P%3BWilson%2C+SE&rft.aulast=Hoskin&rft.aufirst=G&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 ER - TY - CONF T1 - Report on emerging problems in seafoodborne parasitic zoonoses. AN - 16661497; 3018637 AB - The first international conference on foodborne parasitic zoonoses was held November 14-17 1990 at Chiang Mai University, Thailand. The meeting was organized by the Southeast Asian Ministers of Education. The 120 attended at the meeting were from 26 countries. Reports at the conference covered nearly all of the inhabited areas of the world, with emphasis on the clinical/epidemiological background as well as veterinary ramifications. The point of view of food science was represented by a minority of papers. The nomenclature ending for parasitic diseases -iosis- is that recommended by the International Congress on Zoonosis as a means for standardization. Presented in this paper is a discussion of the seafood aspects of the conference with the addition of some necessary background material. Major Objectives of the conference were to: assess the current status of foodborne parasitic illness throughout the world; describe current research activities in foodborne parasitic zoonoses; assess the impact of zoonotic and other foodborne parasitic illnesses on economics and industry; establish collaborative research efforts between conference attendeds with similar interests. Implications for the seafood industry worldwide are reviewed in this paper. JF - REP. FLA. SEA GRANT PROGRAM. pp. 213-225. 1991. AU - Bier, J W Y1 - 1991 PY - 1991 DA - 1991 SP - 213 EP - 225 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Aquaculture Abstracts KW - FLSGP-W-90-001 KW - fishery economics KW - Marine KW - fishery products KW - microbial contamination KW - parasitic diseases KW - geographical distribution KW - conferences KW - pathogens KW - Cryptosporidium parvum KW - oyster fisheries KW - oyster culture KW - human diseases KW - seafood KW - quality control KW - Crassostrea virginica KW - Q3 08583:Shellfish culture KW - Q1 08583:Shellfish culture KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16661497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Report+on+emerging+problems+in+seafoodborne+parasitic+zoonoses.&rft.au=Bier%2C+J+W&rft.aulast=Bier&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 ER - TY - CONF T1 - Recent advances in ciguatera fish poisoning research. AN - 16629534; 3018684 AB - Ciguatera, an illness caused by consumption of a variety of tropical and subtropical species of fish, remains a serious public health and economic problem in many areas of the world. It has been cited as the most frequent cause of illness due to seafood toxins in the United States. Once thought to be caused by one or possibly two toxins (ciguatoxin and maitotoxin) produced by a benthic dinoflagellate (Gambierdiscus toxicus ), it now appears to involve a number of distinct toxins which are elaborated by several species of dinoflagellates. Recent studies examining these toxins and species are discussed. JF - REP. FLA. SEA GRANT PROGRAM. 527 p. 1991. AU - Gramade. H.R. AU - Dickey, R Y1 - 1991 PY - 1991 DA - 1991 SP - 527 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - biological poisons KW - ciguatera KW - ciguatoxins KW - human diseases KW - poisonous organisms KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Marine Biotechnology Abstracts KW - FLSGP-W-90-001 KW - Marine KW - fishery products KW - Gambierdiscus toxicus KW - legislation KW - bioassays KW - Dinophyta KW - toxicity KW - seafood KW - Mugil cephalus KW - quality control KW - public health KW - Q4 27390:Toxins KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08622:Primary products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16629534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Recent+advances+in+ciguatera+fish+poisoning+research.&rft.au=Gramade.+H.R.%3BDickey%2C+R&rft.aulast=Gramade.+H.R.&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Summary only. N1 - Last updated - 2014-05-06 ER - TY - CONF T1 - Toxic fractions of mullet (Mugil cephalus ) viscera. AN - 16591975; 3023915 AB - Four cases of human intoxication resulting from consumption of whole, grilled mullet occurred in California in 1990. The symptoms reported were consistent with those caused by marine polyether toxins such as ciguatoxin or brevetoxin. Fractions of mullet viscera were found toxic in a bioassay; however, the nature of the toxic component is unknown. Although the incidence is rare and limited, the consequences imply the necessity for appropriate care in procurement, distribution records, labeling and consumer education relative to whole fish marketed with viscera intact. JF - REP. FLA. SEA GRANT PROGRAM. 526 p. 1991. AU - Wekell, M M AU - Hungerford, J M AU - Hokamo, Y Y1 - 1991 PY - 1991 DA - 1991 SP - 526 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - FLSGP-W-90-001 KW - Marine KW - fishery products KW - microbial contamination KW - Gambierdiscus toxicus KW - benthos KW - toxicity KW - human diseases KW - seafood KW - ciguatera KW - quality control KW - ciguatoxin KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16591975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Toxic+fractions+of+mullet+%28Mugil+cephalus+%29+viscera.&rft.au=Wekell%2C+M+M%3BHungerford%2C+J+M%3BHokamo%2C+Y&rft.aulast=Wekell&rft.aufirst=M&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Summary only. N1 - Last updated - 2014-05-06 ER - TY - BOOK T1 - Epilogue. (Dioxin conference). AN - 16495258; 2945782 AB - Perhaps the most practical outcome of the meeting was that there was a sense of agreement that the model traditionally used to assess toxin risk is no longer appropriate and that all of the known toxic effects of dioxin appear to be receptor-mediated. This means that for dioxin to have an effect, an undetermined number of receptors must be occupied before any biological or toxic effect is seen, and thus there exists a dose level below which no biologically significant effects can occur. JF - BANBURY REPORT. 1991. AU - Scheuplein, R J AU - Gallo, MA AU - van der Heijden, KA A2 - Gallo, MA A2 - Scheuplein, RJ A2 - van der Heijden, KA (eds) Y1 - 1991 PY - 1991 DA - 1991 PB - COLD SPRING HARBOR LABORATORY PRESS, COLD SPRING HARBOR, NY (USA) SN - 0879692359 KW - PCB KW - epilogue KW - Toxicology Abstracts KW - reviews KW - conferences KW - receptors KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16495258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Scheuplein%2C+R+J%3BGallo%2C+MA%3Bvan+der+Heijden%2C+KA&rft.aulast=Scheuplein&rft.aufirst=R&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0879692359&rft.btitle=Epilogue.+%28Dioxin+conference%29.&rft.title=Epilogue.+%28Dioxin+conference%29.&rft.issn=01980068&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Targeting of workplace inspections for lead. AN - 16484001; 2935179 AB - The prevention of occupational lead poisoning requires identification of worksites with ongoing excessive lead exposures. The utility of different sources of surveillance data in identifying worksites was evaluated by comparing a list of companies inspected by the Occupational Safety and Health Administration (OSHA) for lead with 1) Ohio Bureau of Workers' Compensation (BWC) claims for lead poisoning, and 2) the New York Health Department's Heavy Metal Registry (NYHMR) reports of individuals with elevated blood lead levels. In both states, companies inspected by OSHA were concentrated in larger industries with traditional, well-recognized lead hazards. Companies identified by compensation claims and laboratory reports tended to be in industries dominated by smaller establishments where lead is not a primary part of the industrial process. Sources of surveillance data, such as workers' compensation claims and laboratory reports, identify worksites that tend not to be routinely inspected by OSHA and which need intervention to prevent excessive lead exposure. To maximize the impact of public health resources devoted to the elimination of occupational lead poisoning, follow-up efforts at companies identified by state health departments and workers' compensation systems offer an important opportunity to complement OSHA's inspection efforts. JF - American Journal of Industrial Medicine AU - Seligman, P J AU - Halperin, W E AD - NIOSH, R-21, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 381 EP - 390 VL - 20 IS - 3 SN - 0271-3586, 0271-3586 KW - OSHA KW - inspection KW - Pollution Abstracts KW - poisoning KW - industries KW - lead KW - occupational exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16484001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Targeting+of+workplace+inspections+for+lead.&rft.au=Seligman%2C+P+J%3BHalperin%2C+W+E&rft.aulast=Seligman&rft.aufirst=P&rft.date=1991-01-01&rft.volume=20&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2012-02-28 N1 - SubjectsTermNotLitGenreText - lead; occupational exposure; industries; poisoning ER - TY - JOUR T1 - Adverse behavioral reactions attributed to triazolam in the Food and Drug Administration's Spontaneous Reporting system. AN - 16408950; 2893673 AB - Reports of adverse behavioral reactions to triazolam, a triazolobenzodiazepine ultra-short-acting hypnotic, were examined in the postmarketing surveillance Spontaneous Reporting System of the Food and Drug Administration. Reports for triazolam of confusion, amnesia, bizarre behavior, agitation, and hallucinations were compared with reports of these reactions for temazepam, another short-acting hypnotic. Analysis of individual case reports from marketing through 1985 for triazolam vs temazepam showed 133 vs two for confusion, 109 vs three for amnesia, 59 vs two for bizarre behavior, 58 vs four for agitation, and 40 vs one for hallucinations. Considering extent of use, reporting rates for triazolam were 22 to 99 times those for temazepam, depending on the reaction. JF - Archives of Internal Medicine AU - Wysowski, D K AU - Barash, D AD - Div. Epidemiol. and Surveillance, Cent. Drug Eval. and Res., FDA, Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 2003 EP - 2008 VL - 151 IS - 10 SN - 0003-9926, 0003-9926 KW - triazolam KW - Toxicology Abstracts KW - side effects KW - hypnotics KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16408950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Internal+Medicine&rft.atitle=Adverse+behavioral+reactions+attributed+to+triazolam+in+the+Food+and+Drug+Administration%27s+Spontaneous+Reporting+system.&rft.au=Wysowski%2C+D+K%3BBarash%2C+D&rft.aulast=Wysowski&rft.aufirst=D&rft.date=1991-01-01&rft.volume=151&rft.issue=10&rft.spage=2003&rft.isbn=&rft.btitle=&rft.title=Archives+of+Internal+Medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - side effects; man; hypnotics ER - TY - JOUR T1 - Lung cancer incidence among patients with beryllium disease: A cohort mortality study. AN - 16340737; 2849818 AB - We have conducted a cohort mortality study on 689 patients with beryllium disease who were included in a case registry. Comparison of the 689 beryllium disease patients with the U.S. population resulted in a lung cancer standardized mortality ratio (SMR) of 2.00 based on 28 observed lung cancer deaths. Adjustment for smoking did not change these results. All causes of mortality were also significantly elevated, largely because of the very high rate of deaths due to pneumoconioses (primarily beryllium disease). No other causes of death were significantly elevated. The excess of lung cancer was consistent for both sexes and did not appear to increase with duration of exposure to beryllium or with time elapsed since first exposure to this element. JF - Journal of the National Cancer Institute AU - Steenland, K AU - Ward, E AD - Mailstop R13, NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1380 EP - 1385 VL - 83 IS - 19 SN - 0027-8874, 0027-8874 KW - disease KW - relationships KW - man KW - beryllium KW - lung cancer KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - lung KW - metals KW - cancer KW - X 24162:Chronic exposure KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16340737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lung+cancer+incidence+among+patients+with+beryllium+disease%3A+A+cohort+mortality+study.&rft.au=Steenland%2C+K%3BWard%2C+E&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-01-01&rft.volume=83&rft.issue=19&rft.spage=1380&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - beryllium; lung; cancer; metals; lung cancer; man ER - TY - CONF T1 - Validation of biological markers for quantitative risk assessment. AN - 16315766; 2826241 AB - The evaluation of biological markers is recognized as necessary to the future of toxicology, epidemiology, and quantitative risk assessment. For biological markers to become widely accepted, their validity must be ascertained. This paper explores the range of considerations that compose the concept of validity as it applies to the evaluation of biological markers. Three broad categories of validity (measurement, internal study, and external) are discussed in the context of evaluating data for use in quantitative risk assessment. Particular attention is given to the importance of measurement validity in the consideration of whether to use biological markers in epidemiologic studies. The concepts developed in this presentation are applied to examples derived from the occupational environment. In the first example, measurement of bromine release as a marker of ethylene dibromide toxicity is shown to be of limited use in constructing an accurate quantitative assessment of the risk of developing cancer as a result of long-term, low-level exposure. This example is compared to data obtained from studies of ethylene oxide, in which hemoglobin alkylation is shown to be a valid marker of both exposure and effect. JF - Environmental Health Perspectives AU - Schulte, P AU - Mazzuckelli, L F Y1 - 1991 PY - 1991 DA - 1991 SP - 239 EP - 246 VL - 90 KW - biology KW - markers KW - Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - toxicology KW - epidemiology KW - risk assessment KW - H SM3.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - R2 23060:Medical and environmental health KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16315766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Validation+of+biological+markers+for+quantitative+risk+assessment.&rft.au=Schulte%2C+P%3BMazzuckelli%2C+L+F&rft.aulast=Schulte&rft.aufirst=P&rft.date=1991-01-01&rft.volume=90&rft.issue=&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Interaction of copper with DNA and antagonism by other metals. AN - 16291873; 2808893 AB - Copper (Cu(II)) has been shown to enhance DNA damage in several biological systems. Binding of copper to DNA may be a key step in producing these lesions. The results of this study indicate that the DNA double helix contains at least two kinds of binding sites for copper. One site is present once every four nucleotides, has high affinity, and shows a cooperative effect. The other is an intercalating site for copper that is present in every base pair. This site is saturable, has a dissociation constant (K sub(d)) for CU(II) of 41 mu M. In single-stranded DNA, we found an average copper binding site every three nucleotides with lower affinity than in dsDNA. The binding of copper to DNA shows an unexpected high specificity when studied in the presence of other metallic ions. The relative efficacy of several divalent cations to antagonize Cu(II) binding was: Ni = Cd = Mg >> Zn = Hg > Ca > Pb >> Mn, while Cr(VI) enhanced Cu(II) binding to DNA. JF - Toxicology and Applied Pharmacology AU - Sagripanti, J-I AU - Goering, P L AU - Lamanna, A AD - (HFZ-113) CDRH, FDA, 12709 Twinbrook Pkwy, Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 477 EP - 485 VL - 110 IS - 3 SN - 0041-008X, 0041-008X KW - copper KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - antagonism KW - metals KW - DNA KW - interaction KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16291873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Interaction+of+copper+with+DNA+and+antagonism+by+other+metals.&rft.au=Sagripanti%2C+J-I%3BGoering%2C+P+L%3BLamanna%2C+A&rft.aulast=Sagripanti&rft.aufirst=J-I&rft.date=1991-01-01&rft.volume=110&rft.issue=3&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA; interaction; metals; antagonism ER - TY - JOUR T1 - Evaluation of sorbents for the collection and analysis of trace levels of airborne vapors: Bis(2-chloroethyl)sulfide (mustard), a case study. AN - 16291094; 2811535 AB - Investigations from the National Institute for Occupational Safety and Health (NIOSH) have conducted research on air monitoring methods that the Department of Defense uses for measuring the workplace and environmental concentrations of chemical warfare agents. This paper concerns works on part of this research which was aimed at evaluating sorbents for the collection of the blister agent bis(2-chloroethyl)sulfate, known as mustard or HD, from air. Twenty-three sorbents were screened and compared to Tenax, the currently-used sorbent. JF - Chemosphere AU - Posner, J C AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 461 EP - 472 VL - 22 IS - 5-6 SN - 0045-6535, 0045-6535 KW - mustard KW - air pollutants KW - vapor KW - munitions KW - bis(2-chloroethyl)sulfide KW - Pollution Abstracts KW - sorption KW - monitoring methods KW - chemicals KW - military KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16291094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Evaluation+of+sorbents+for+the+collection+and+analysis+of+trace+levels+of+airborne+vapors%3A+Bis%282-chloroethyl%29sulfide+%28mustard%29%2C+a+case+study.&rft.au=Posner%2C+J+C&rft.aulast=Posner&rft.aufirst=J&rft.date=1991-01-01&rft.volume=22&rft.issue=5-6&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - chemicals; sorption; military; monitoring methods ER - TY - JOUR T1 - Histamine and endotoxin contamination of hay and respirable hay dust. AN - 16261068; 2802534 AB - Three distinct samples collected from a barn in which an outbreak of respiratory problems occurred were examined for possible etiologic agents. No causal relationship could be established from the results of this study; however histamine concentrations as high as 0.5 ng/mg for bulk hay (in the absence of measurable creatinine levels) along with 6138.3 endotoxin units/mg of hay were present in the samples. Both endotoxin and histamine could be recovered from respirable hay dust. The authenticity of the histamine found in the hay was evaluated with high-performance liquid chromatography and radioimmunoassay. Histamine release caused by hay extracts was evaluated with the use of leukocytes from the farmer and a referent. Histamine is known to modulate the immune system, but the role of occupational or environmental exposure to histamine in respiratory disease is unknown. JF - Scandinavian Journal of Work, Environment & Health AU - Siegel, P D AU - Olenchock, SA AU - Sorenson, W G AU - Lewis, D M AU - Bledsoe, T A AU - May, J J AU - Pratt, D S AD - Biochem. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 276 EP - 280 VL - 17 IS - 4 SN - 0355-3140, 0355-3140 KW - hay KW - histamine KW - respiratory tract diseases KW - man KW - respiratory diseases KW - Pollution Abstracts; Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - endotoxins KW - occupational exposure KW - dust KW - X 24171:Microbial KW - H SI0.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES KW - J 02823:In vitro and in vivo effects KW - H SE2.8.7:DUST UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16261068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Histamine+and+endotoxin+contamination+of+hay+and+respirable+hay+dust.&rft.au=Siegel%2C+P+D%3BOlenchock%2C+SA%3BSorenson%2C+W+G%3BLewis%2C+D+M%3BBledsoe%2C+T+A%3BMay%2C+J+J%3BPratt%2C+D+S&rft.aulast=Siegel&rft.aufirst=P&rft.date=1991-01-01&rft.volume=17&rft.issue=4&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; endotoxins; respiratory diseases; occupational exposure; hay; respiratory tract diseases; man ER - TY - JOUR T1 - Cloning and sequencing of the structural gene for the porin protein of Bordetella pertussis . AN - 16256863; 2783246 AB - Bordetella pertussis produces a porin protein which is a prominent outer membrane component found in both virulent and avirulent strains. N-terminal amino acid analysis of purified B. pertussis porin was performed and this amino acid sequence was used to design an oligonucleotide that was then utilized to screen a lambda gt11 library containing randomly sheared fragments of DNA from B. pertussis strain 347. DNA hybridization studies indicated that both virulent and avirulent strains of B. pertussis contain only one copy of this gene and that Bordetella bronchiseptica and Bordetella parapetussie contain a similar gene. JF - Molecular Microbiology AU - Li, Z M AU - Hannah, J H AU - Stibitz, S AU - Nguyen, N Y AU - Manclark, C R AU - Brennan, MJ AD - Div. Bact. Prod., Cent. Biol. Eval. and Res., FDA, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1649 EP - 1656 VL - 5 IS - 7 SN - 0950-382X, 0950-382X KW - Bordetella pertussis KW - DNA KW - amino acid analysis KW - genes KW - hybridization analysis KW - nucleotide sequence KW - porins KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14640:Structure & sequence KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16256863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Cloning+and+sequencing+of+the+structural+gene+for+the+porin+protein+of+Bordetella+pertussis+.&rft.au=Li%2C+Z+M%3BHannah%2C+J+H%3BStibitz%2C+S%3BNguyen%2C+N+Y%3BManclark%2C+C+R%3BBrennan%2C+MJ&rft.aulast=Li&rft.aufirst=Z&rft.date=1991-01-01&rft.volume=5&rft.issue=7&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - nucleotide sequence; porins; hybridization analysis; genes; DNA ER - TY - JOUR T1 - Propanil: Toxicological characteristics, metabolism, and biodegradation potential in soil. AN - 16250933; 2777554 AB - Propanil (3',4'-dichloropropionanilide (DCPA)) is a biologically active pollutant. Propanil is extensively used around the world for control of weeds in rice (Oryza sativa L.) production. Although propanil by itself is of low toxicity, the highly toxic impurities 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) from the manufacture of 3,4-dichloroaniline (DCA) often contaminate the 3,4-DCA-derived herbicide propanil. In soil, biodegradation of propanil liberates DCA, which is converted by microbial peroxidases to TCAB and other azo products. The TCAB and TCAOB may accumulate in rice-growing soils, and leach into groundwater. The toxicity and fate of these compounds in the environment and the ability of microorganisms to detoxify them are discussed. JF - Journal of Environmental Quality AU - Pothuluri, J V AU - Hinson, JA AU - Cerniglia, CE AD - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 330 EP - 347 VL - 20 IS - 2 SN - 0047-2425, 0047-2425 KW - propanil KW - 3,4-dichloroaniline KW - formation KW - 3,3',4,4'-tetrachloroazobenzene KW - soils KW - Pollution Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - biodegradation KW - metabolism KW - toxicology KW - soil microorganisms KW - microorganisms KW - A 01054:Effect of herbicides KW - J 02901:Soil and plants KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16250933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Propanil%3A+Toxicological+characteristics%2C+metabolism%2C+and+biodegradation+potential+in+soil.&rft.au=Pothuluri%2C+J+V%3BHinson%2C+JA%3BCerniglia%2C+CE&rft.aulast=Pothuluri&rft.aufirst=J&rft.date=1991-01-01&rft.volume=20&rft.issue=2&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - soil microorganisms; biodegradation; toxicology; metabolism; microorganisms; formation ER - TY - JOUR T1 - The regulatory evolution of the integrated safety summary. AN - 16153744; 2703634 AB - It now seems perfectly obvious that the safety evaluation of a new drug must be based on an integrated summary, an overview, of the adverse event data from all sources, particularly all of the clinical trial data. Ie, safety evaluation is inherently a meta-analysis, although it is one whose rules are even less clear than the rules for effectiveness meta-analysis. The explicit recognition that the safety evaluation is an overview is relatively recent, and it does not appear that in the fairly recent past we expected the sponsor or the reviewer to take this approach. There were hints that an overview approach might be appropriate but the principal focus of the review and the sponsor's submission was the individual clinical studies, especially the controlled studies. JF - Drug Information Journal AU - Temple, R J AD - Off. Drug Eval. I, FDA, 5600 Fishers Lane HFN-100, Rm. 14B45, Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 485 EP - 492 VL - 25 IS - 4 SN - 0092-8615, 0092-8615 KW - pharmaceuticals KW - regulation KW - Toxicology Abstracts KW - side effects KW - safety KW - X 24230:Legislation & recommended standards KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16153744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=The+regulatory+evolution+of+the+integrated+safety+summary.&rft.au=Temple%2C+R+J&rft.aulast=Temple&rft.aufirst=R&rft.date=1991-01-01&rft.volume=25&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - safety; side effects ER - TY - JOUR T1 - An overview of gamma -hydroxybutyrate catabolism: The role of the cytosolic NADP super(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway. AN - 16146788; 2699438 JF - Neurochemical Research AU - Kaufman, EE AU - Nelson, T AD - Natl. Inst. Mental Health, United States Public Health Service, Dep. Health Human Serv., Build. 36, 1A-05, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 965 EP - 974 VL - 16 IS - 9 SN - 0364-3190, 0364-3190 KW - catabolism KW - cytosol KW - gamma -hydroxybutyrate KW - glucuronate reductase KW - hydroxyacid-oxoacid transhydrogenase KW - mitochondria KW - reviews KW - role KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Marine KW - Brackish KW - Freshwater KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16146788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=An+overview+of+gamma+-hydroxybutyrate+catabolism%3A+The+role+of+the+cytosolic+NADP+super%28%2B%29-dependent+oxidoreductase+EC+1.1.1.19+and+of+a+mitochondrial+hydroxyacid-oxoacid+transhydrogenase+in+the+initial%2C+rate-limiting+step+in+this+pathway.&rft.au=Kaufman%2C+EE%3BNelson%2C+T&rft.aulast=Kaufman&rft.aufirst=EE&rft.date=1991-01-01&rft.volume=16&rft.issue=9&rft.spage=965&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - reviews; Marine; Brackish; Freshwater ER - TY - JOUR T1 - Completeness of adverse drug experience reporting by manufacturers to the FDA. AN - 16140685; 2688301 AB - This project evaluated the completeness of manufacturer adverse drug experience (ADE) reports on computerized fields on the FDA-1639 form for which completion is not required for data entry, (eg, age, sex, ADE onset date). The completion rate of such fields was determined for domestic, spontaneous, health professional-submitted ADE reports during 1986-1989. This project was limited to 20 manufacturers submitting the largest number of reports. Completion rates were computed for total reports and 15-day reports. A completion rate was defined for each field for each manufacturer as the number of times the field was filled in divided by the total number of reports. JF - Drug Information Journal AU - Britt, AL AU - Knapp, DE AU - Anello, C AU - Perry, Z A AD - HFD-737, FDA, 5600 Fishers Ln., Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 599 EP - 606 VL - 25 IS - 4 SN - 0092-8615, 0092-8615 KW - pharmaceuticals KW - surveillance KW - Toxicology Abstracts KW - side effects KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16140685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Completeness+of+adverse+drug+experience+reporting+by+manufacturers+to+the+FDA.&rft.au=Britt%2C+AL%3BKnapp%2C+DE%3BAnello%2C+C%3BPerry%2C+Z+A&rft.aulast=Britt&rft.aufirst=AL&rft.date=1991-01-01&rft.volume=25&rft.issue=4&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - side effects ER - TY - CONF T1 - USFDA assessment of exposure to 2,3,7,8-TCDD 2,3,7,8-TCDF from foods contacting bleached paper products. AN - 16140527; 2688129 AB - Migration studies with paper food-contact articles thought to represent the greatest potential for exposure to 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) showed that measurable migration occurred with all articles tested. The Food and Drug Administration (FDA) combined these results with food consumption estimates to evaluate potential exposure to TCDD and TCDF from bleached paper food-contact articles. JF - Chemosphere AU - Cramer, G AU - Bolger, M AU - Henry, S AU - Lorentzen, R Y1 - 1991 PY - 1991 DA - 1991 SP - 1537 EP - 1550 VL - 23 IS - 8-10 KW - TCDD KW - paper products KW - FDA KW - TCDF KW - foods KW - 2,3,7,8-tetrachlorodibenzofuran KW - paper KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - food KW - contamination KW - H SE4.27:FOOD PROCESSING INDUSTRIES KW - X 24120:Food, additives & contaminants KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16140527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=USFDA+assessment+of+exposure+to+2%2C3%2C7%2C8-TCDD+2%2C3%2C7%2C8-TCDF+from+foods+contacting+bleached+paper+products.&rft.au=Cramer%2C+G%3BBolger%2C+M%3BHenry%2C+S%3BLorentzen%2C+R&rft.aulast=Cramer&rft.aufirst=G&rft.date=1991-01-01&rft.volume=23&rft.issue=8-10&rft.spage=1537&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - PAT T1 - Assay for Mycoplasma fermentans . AN - 16140521; 2680227 AB - An assay for detecting the presence of Mycoplasma fermentans comprises the steps of: obtaining a nuclear extract from a sample of cells suspected of the presence of Mycoplasma fermentans ; and testing the extract for Mfe I activity, the presence of Mfe I activity being indicative of the presence of Mycoplasma fermentans . AU - Leonard, W J AU - Wolf, J B AU - Halden, N F PY - 1991 IS - US Patent 5,073,486 KW - detection KW - extracts KW - Mfe I activity KW - Mycoplasma fermentans KW - nuclei KW - patents KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - W 30050:Patents KW - A 01114:Viruses KW - W 30507:Diagnostic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16140521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Assay+for+Mycoplasma+fermentans+.&rft.au=Leonard%2C+W+J%3BWolf%2C+J+B%3BHalden%2C+N+F&rft.aulast=Leonard&rft.aufirst=W&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/19; Int. Cl. C12R 1/35, C12Q 1/34, C12N 9/22. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Evaluation of chronic bronchitis, chronic obstructive pulmonary disease, and ventilatory function among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. AN - 16136655; 2688037 AB - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is produced as an undesirable contaminant in the manufacture of 2,4,5-trichlorophenol (TCP) and its derivatives. There is considerable concern about the health effects that may be associated with exposure to TCDD-contaminated substances. A cross-sectional medical study that included a comprehensive medical history, medical examination, and measurement of pulmonary function was conducted on workers employed more than 15 yr earlier in the manufacture of NaTCP and its derivatives at two chemical plants. No difference was found between workers and referents in the risk for chronic bronchitis or COPD. Analysis of the ventilatory function data revealed no association between history of exposure to substances contaminated with TCDD and the forced expiratory volume at one second (FEV sub(1)), forced vital capacity (FVC), or the ratio of FEV sub(1) to FVC (FEV sub(1)/FVC%). JF - American Journal of Respiratory and Critical Care Medicine AU - Calvert, G M AU - Sweeney, M H AU - Morris, JA AU - Fingerhut, MA AU - Hornung, R W AU - Halperin, W E AD - NIOSH, 4676 Columbia Pkwy., R-16, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1303 EP - 1306 VL - 144 IS - 6 SN - 0003-0805, 0003-0805 KW - TCDD KW - function KW - bronchitis KW - chronic obstructive pulmonary disease KW - man KW - respiratory tract diseases KW - respiratory diseases KW - occupational health KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - lung KW - occupational exposure KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16136655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Evaluation+of+chronic+bronchitis%2C+chronic+obstructive+pulmonary+disease%2C+and+ventilatory+function+among+workers+exposed+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Calvert%2C+G+M%3BSweeney%2C+M+H%3BMorris%2C+JA%3BFingerhut%2C+MA%3BHornung%2C+R+W%3BHalperin%2C+W+E&rft.aulast=Calvert&rft.aufirst=G&rft.date=1991-01-01&rft.volume=144&rft.issue=6&rft.spage=1303&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational exposure; lung; respiratory diseases; occupational health; chronic obstructive pulmonary disease; man; respiratory tract diseases ER - TY - JOUR T1 - Co-amplification of specific sequences of HCV and HIV-1 genomes by using the polymerase chain reaction assay: A potential tool for the simultaneous detection of HCV and HIV-1. AN - 16129602; 2686693 AB - A rapid and simple method using the polymerase chain reaction (PCR) was devised for the co-amplification and simultaneous detection of hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) specific sequences in the same serum sample. Genomic RNA was extracted from 13 blood donor sera that were reactive in ELISA for both anti-HCV and anti-HIV-1. The extracted RNA was reverse transcribed into cDNA and amplified using nested primer pairs (SN01 and SN04; SN02 and SN03) based on the HCV prototype sequence of clones 37b and 81, and SK 38/39 for HIV-1 simultaneously. The ability to co-amplify specific sequences from two different viral genomes in the same reaction mixture offers the possibility of simultaneous detection and diagnosis of more than one viral agent in serum samples of infected individuals. JF - Journal of Virological Methods AU - Nedjar, S AU - Biswas, R M AU - Hewlett, I K AD - DTS, CBER, FDA, 8800 Rockville Pike, Build. 29/B-03, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 297 EP - 304 VL - 35 IS - 3 SN - 0166-0934, 0166-0934 KW - human immunodeficiency virus 1 KW - oligonucleotides KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - nucleotide sequence KW - RNA KW - hybridization analysis KW - cDNA KW - genes KW - V 22002:AIDS: Molecular and in vitro aspects KW - A 01114:Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16129602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Co-amplification+of+specific+sequences+of+HCV+and+HIV-1+genomes+by+using+the+polymerase+chain+reaction+assay%3A+A+potential+tool+for+the+simultaneous+detection+of+HCV+and+HIV-1.&rft.au=Nedjar%2C+S%3BBiswas%2C+R+M%3BHewlett%2C+I+K&rft.aulast=Nedjar&rft.aufirst=S&rft.date=1991-01-01&rft.volume=35&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - genes; nucleotide sequence; RNA; cDNA; hybridization analysis ER - TY - PAT T1 - Nucleotide, deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins. AN - 16128821; 2677175 AU - Morrison, R P AU - Caldwell, H D PY - 1991 IS - US Patent 5,071,962 KW - patents KW - Chlamydia KW - amino acid sequence KW - heat-shock proteins KW - proteins KW - Biotechnology and Bioengineering Abstracts KW - W 30404:Other peptides and proteins KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16128821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Nucleotide%2C+deduced+amino+acid+sequence%2C+isolation+and+purification+of+heat-shock+chlamydial+proteins.&rft.au=Morrison%2C+R+P%3BCaldwell%2C+H+D&rft.aulast=Morrison&rft.aufirst=R&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 530/387; Int. Cl. A61K 35/14, C07K 3/00, 13/00, 15/00. N1 - Last updated - 2011-12-13 ER - TY - PAT T1 - Method of treatment of hepatitis. AN - 16112545; 2662107 AB - A method for treating hepatitis B comprises administering to a patient infected with hepatitis B an anti-hepatitis B effective amount of a nucleoside selected from the group consisting of 2',3'-dideoxyinosine, 2',3'-dideoxyadenosine, and 2',3'-dideoxyguanosine. AU - Hoofnagle, J H AU - Broder, S AU - Mitsuya, H AU - Yarchoan, R PY - 1991 IS - US Patent 5,070,077 KW - patents KW - nucleosides KW - 2',3'-dideoxyinosine KW - 2',3'-dideoxyadenosine KW - 2',3'-dideoxyguanosine KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antiviral agents KW - hepatitis B virus KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16112545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Method+of+treatment+of+hepatitis.&rft.au=Hoofnagle%2C+J+H%3BBroder%2C+S%3BMitsuya%2C+H%3BYarchoan%2C+R&rft.aulast=Hoofnagle&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/45; Int. Cl. A61K 31/70. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Regulatory concerns in human gene therapy. AN - 16103468; 2661559 AB - Gene therapy in humans is now being undertaken in an investigational setting. Such therapy involves the administration of biological products to human patients. A document entitled, "Points to Consider in Human Somatic Cell Therapy and Gene Therapy" has been prepared by the Center for Biologics Evaluation and Research (CBER) of the Food and Drug Administration (FDA) and is published elsewhere in this issue. This paper provides explanatory material about the CBER regulatory process and the scientific and regulatory basis for the requests for data in that document. JF - Human Gene Therapy AU - Epstein, S L AD - FDA, CBER, OBR, DBB, Build. 29, Rm. 522, HFB-710, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 243 EP - 249 VL - 2 IS - 3 SN - 1043-0342, 1043-0342 KW - gene transfer KW - man KW - gene therapy KW - government policy KW - government regulations KW - legal aspects KW - genetic engineering KW - genetics KW - safety KW - safety regulations KW - Risk Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - R2 23090:Policy and planning KW - W 30121:Transduction and transfection KW - W 30506:Therapeutic KW - H SM5.5:STANDARDS, LAWS, REGULATIONS, AND POLICY KW - G 07439:General - reviews/ethics, etc. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16103468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Regulatory+concerns+in+human+gene+therapy.&rft.au=Epstein%2C+S+L&rft.aulast=Epstein&rft.aufirst=S&rft.date=1991-01-01&rft.volume=2&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - genetic engineering; safety regulations; government regulations; genetics; safety; legal aspects; government policy ER - TY - PAT T1 - Treatment of a microbial infection with drugs containing para-acetamidobenzoic acid. AN - 16091607; 2650695 AU - Kovacs, J AU - Masur, H AU - Allegra, C PY - 1991 IS - US Patent 5,068,253 KW - patents KW - p-acetamidobenzoic acid KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antimicrobial agents KW - A 01069:Antimicrobial & microbiocidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16091607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Treatment+of+a+microbial+infection+with+drugs+containing+para-acetamidobenzoic+acid.&rft.au=Kovacs%2C+J%3BMasur%2C+H%3BAllegra%2C+C&rft.aulast=Kovacs&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/553; Int. Cl. A61K 31/185. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Characterisation of respiratory health and exposures at a sintered permanent magnet manufacturer. AN - 16081943; 2645425 AB - Sintered permanent magnets are made from the powdered metals of cobalt, nickel, aluminium, and various rare earths. During production, exposure to respirable crystalline silica and asbestos may also occur. Reported here is a cross sectional study of 310 current and 52 retired hourly employees who worked 10 or more years making sintered magnets. Each participant had a chest radiograph, spirometry, and completed a respiratory questionnaire. Illness logs were also reviewed to calculate the incidence of recorded respiratory disorders. The prevalences of abnormalities in pulmonary function and respiratory symptoms were not higher than found in an external referent population. Although the prevalence of diffuse parenchymal opacities consistent with pneumoconiosis (four workers) was similar to the referent population, one worker had radiographic findings consistent with silicosis and two workers had profusion scores of 1/2 or above, not seen in the referent group. JF - Occupational and Environmental Medicine AU - Deng, Jou-Fang AU - Sinks, T AU - Elliott, L AU - Smith, D AU - Singal, M AU - Fine, L AD - Div. Surveill., NIOSH, 4676 Columbia Pkwy., R-10, Cincinnati, OH 45261, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 609 EP - 615 VL - 48 IS - 9 SN - 0007-1072, 0007-1072 KW - respiratory system KW - humans KW - magnet manufacturer KW - occupational health KW - silicon dioxide KW - asbestos KW - occupational hazards KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - silicosis KW - metals KW - pneumoconiosis KW - H SI2.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16081943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Characterisation+of+respiratory+health+and+exposures+at+a+sintered+permanent+magnet+manufacturer.&rft.au=Deng%2C+Jou-Fang%3BSinks%2C+T%3BElliott%2C+L%3BSmith%2C+D%3BSingal%2C+M%3BFine%2C+L&rft.aulast=Deng&rft.aufirst=Jou-Fang&rft.date=1991-01-01&rft.volume=48&rft.issue=9&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - metals; occupational health; pneumoconiosis; asbestos; silicosis; occupational hazards ER - TY - PAT T1 - Kit for diagnosing cancer metastatic potential. AN - 16074225; 2634220 AU - Steeg, P S AU - Liotta, LA AU - Sobel, ME AU - Bevilacqua, G PY - 1991 IS - US Patent 5,049,662 KW - patents KW - NM23 gene KW - diagnosis KW - cancer KW - genes KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16074225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Kit+for+diagnosing+cancer+metastatic+potential.&rft.au=Steeg%2C+P+S%3BLiotta%2C+LA%3BSobel%2C+ME%3BBevilacqua%2C+G&rft.aulast=Steeg&rft.aufirst=P&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 536/27; Int. Cl. C07H 15/12, 17/00; C12Q 1/68. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Quantitative determination of trucking industry workers' exposures to diesel exhaust particles. AN - 16072587; 2640641 AB - As part of a case-control mortality study of trucking industry workers, exposures to diesel aerosol were measured among the four major presumably exposed job groups (road divers, local divers, dock workers, and mechanics) in the industry. Eight industrial hygiene surveys were conducted during both warm and cold weather at eight U.S. terminals and truck repair shops. A single-state personal impactor was used to sample submicrometer-sized diesel particles on quartz-fiber filters. Laboratory and field studies demonstrated that the elemental carbon content of the particles is a useful and practical maker of exposure to vehicular diesel exhaust. A thermal-optical analysis technique was used to determine the concentration of elemental carbon in the filter samples. Overall geometric mean exposures to submicrometer-sized elemental carbon ranged from 3.8 mu g/m super(3) in road (long distance) drivers (N = 72) to 13.8 mu g/m super(3) in dock workers (N = 75). JF - American Industrial Hygiene Association Journal AU - Zaebst, D D AU - Clapp, DE AU - Blade, L M AU - Marlow, DA AU - Steenland, K AU - Hornung, R W AU - Scheutzle, D AU - Butler, J AD - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 529 EP - 541 VL - 52 IS - 12 SN - 0002-8894, 0002-8894 KW - trucks KW - Health & Safety Science Abstracts; Pollution Abstracts KW - occupational health KW - air sampling KW - particle size KW - exhaust emissions KW - mortality KW - aerosols KW - filters KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - H ST2.21:TRUCKS KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16072587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Quantitative+determination+of+trucking+industry+workers%27+exposures+to+diesel+exhaust+particles.&rft.au=Zaebst%2C+D+D%3BClapp%2C+DE%3BBlade%2C+L+M%3BMarlow%2C+DA%3BSteenland%2C+K%3BHornung%2C+R+W%3BScheutzle%2C+D%3BButler%2C+J&rft.aulast=Zaebst&rft.aufirst=D&rft.date=1991-01-01&rft.volume=52&rft.issue=12&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - exhaust emissions; aerosols; particle size; air sampling; filters; occupational health; mortality ER - TY - JOUR T1 - Purification and characterization of an endotoxin-binding protein with protease inhibitory activity from Limulus amebocytes. AN - 16062778; 2627971 AB - Using a lipopolysaccharide affinity column and ion exchange chromatography, a 12-kDa protein has been purified from Limulus amebocytes. A cDNA coding for this protein has been isolated and sequenced. The amino acid sequence deduced from the cDNA indicates that this protein shares no sequence homology with LPS-binding proteins isolated from different species of vertebrates and invertebrates. Using both ( super(14)C)casein and a synthetic substrate, the protein has been shown to inhibit the proteolytic activity of trypsin, with an IC sub(50) of similar to 10 super(-7) M. In the presence of LPS, the antitryptic activity of the Limulus endotoxin-binding protein-protease inhibitor remains unaffected. The protein is a major component of the cytoplasmic proteins (1%). Immunocytochemical analysis reveals that this protein exists in the secretory granules of the amebocytes where enzymes and substrates for the clotting cascade reside. Based on the unusual dual functional properties, the newly isolated protein was named a "Limulus endotoxin-binding protein-protease inhibitor" (LEBP-PI). JF - Journal of Biological Chemistry AU - Minetti, CASA AU - Lin, Yuan AU - Cislo, T AU - Liu, Teh-Yung AD - Div. Biochem. and Biophys., Cent. Biol. Eval. and Res., FDA, Rm. 516, Build. 29, 8800 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 20773 EP - 20780 VL - 266 IS - 31 SN - 0021-9258, 0021-9258 KW - Limulus KW - amino acid sequence KW - amino acids KW - amoebocytes KW - chemical extraction KW - endotoxin-binding protein KW - enzymatic activity KW - enzyme inhibitors KW - inhibitors KW - predictions KW - protease inhibitors KW - protein synthesis KW - proteinase KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Q1 08286:Physiology, biochemistry, biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16062778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Purification+and+characterization+of+an+endotoxin-binding+protein+with+protease+inhibitory+activity+from+Limulus+amebocytes.&rft.au=Minetti%2C+CASA%3BLin%2C+Yuan%3BCislo%2C+T%3BLiu%2C+Teh-Yung&rft.aulast=Minetti&rft.aufirst=CASA&rft.date=1991-01-01&rft.volume=266&rft.issue=31&rft.spage=20773&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - protein synthesis; enzyme inhibitors; amoebocytes; chemical extraction; amino acids; Marine ER - TY - JOUR T1 - DNA strand breaks and DNA repair response in lymphocytes after chronic in vivo exposure to very low doses of ionizing radiation in mice. AN - 16061254; 2617263 AB - We have examined whether whole-body exposure to low-dose radiation (LDR) results in an alteration in constitutive (steady state) levels of DNA-strand breaks and whether an adaptive increase in DNA-repair response is induced. The results indicated that the constitutive expression of DNA-strand breaks is significantly decreased after chronic LDR; however, DNA-repair capacity after high-dose radiation exposure is not increased above that observed in sham-irradiated mice. JF - Mutation Research AU - James, S J AU - Enger, S M AU - Makinodan, T AD - Dep. Health and Hum. Serv., FDA, Natl. Cent. Toxicol. Res., Div. Comp. Toxicol., NCTR Dr., Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 255 EP - 263 VL - 249 IS - 1 SN - 0027-5107, 0027-5107 KW - gamma radiation KW - strands KW - breaks KW - mice KW - Toxicology Abstracts; Genetics Abstracts KW - DNA KW - DNA repair KW - X 24210:Radiation & radioactive materials KW - G 07231:Radiation (gamma) KW - G 07420:GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16061254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=DNA+strand+breaks+and+DNA+repair+response+in+lymphocytes+after+chronic+in+vivo+exposure+to+very+low+doses+of+ionizing+radiation+in+mice.&rft.au=James%2C+S+J%3BEnger%2C+S+M%3BMakinodan%2C+T&rft.aulast=James&rft.aufirst=S&rft.date=1991-01-01&rft.volume=249&rft.issue=1&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA repair; DNA ER - TY - JOUR T1 - Mathematical modeling of reproductive and developmental toxic effects for quantitative risk assessment. AN - 16055659; 2613144 AB - A new mathematical dose-response model for reproductive and developmental risk assessment is proposed. The model includes the possibility of an exposure threshold as well as a litter-size effect. Correlation of responses of offspring from the same litter is taken into account through the use of the beta-binomial distribution. Confidence limits for low-dose extrapolation are based on the asymptotic distribution of the likelihood ratio. An empirical comparison of the proposed procedure to that of Rai and Van Ryzin demonstrates the improvement that can be achieved with the new procedure. JF - Risk Analysis AU - Kodell, R L AU - Howe, R B AU - Chen, J J AU - Gaylor, D W AD - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 583 EP - 590 VL - 11 IS - 4 SN - 0272-4332, 0272-4332 KW - mathematical models KW - dose response effects KW - Risk Abstracts; Pollution Abstracts KW - toxicity KW - statistical analysis KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16055659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Mathematical+modeling+of+reproductive+and+developmental+toxic+effects+for+quantitative+risk+assessment.&rft.au=Kodell%2C+R+L%3BHowe%2C+R+B%3BChen%2C+J+J%3BGaylor%2C+D+W&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-01-01&rft.volume=11&rft.issue=4&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - toxicity; statistical analysis ER - TY - JOUR T1 - Effects of neonatal diethylstilbestrol exposure on the growth of mouse vaginal epithelial cells in serum-free collagen gel culture. AN - 16050657; 2608444 AB - Vaginal epithelial cells isolated from ovariectomized ca. 40-day-old BALB/cCrgl mice treated with 1 mu g diethylstilbestrol (DES) or with oil vehicle alone for the first 5 days after birth were purified by Percoll density gradient centrifugation and grown as primary cultures in collagen gel matrix (CGM) with serum-free medium. Three dimensional colonies of both control and DES-exposed vaginal epithelial cells developed in the CGM. The initial proliferation rate of DES-exposed vaginal epithelial cells was significantly lower than that of the controls. After 10 days in culture, approximately 6.3-fold and 7.6-fold increases in cell number occurred in control and DES-exposed vaginal epithelial cells, respectively, a difference that is not significant. Deletion of bovine serum albumin, bovine insulin or mouse epidermal growth factor (EGF) resulted in decreased growth of both control and DES-exposed vaginal epithelial cells. Estradiol-17 beta (180 fM to 18 nM) did not stimulate growth of control or DES-exposed vaginal epithelial cells. JF - Zoological Science AU - Uchima, F-DA AU - Iguchi, T AU - Pattamakom, S AU - Mills, K T AU - Bern, HA AD - Dep. Integr. Biol., Univ. California, Berkeley, CA 94720, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 713 EP - 719 VL - 8 IS - 4 SN - 0289-0003, 0289-0003 KW - diethylstilbestrol KW - tissue culture KW - growth KW - mice KW - Toxicology Abstracts KW - prenatal experience KW - vagina KW - epithelium KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16050657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zoological+Science&rft.atitle=Effects+of+neonatal+diethylstilbestrol+exposure+on+the+growth+of+mouse+vaginal+epithelial+cells+in+serum-free+collagen+gel+culture.&rft.au=Uchima%2C+F-DA%3BIguchi%2C+T%3BPattamakom%2C+S%3BMills%2C+K+T%3BBern%2C+HA&rft.aulast=Uchima&rft.aufirst=F-DA&rft.date=1991-01-01&rft.volume=8&rft.issue=4&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Zoological+Science&rft.issn=02890003&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - prenatal experience; vagina; epithelium ER - TY - JOUR T1 - Additive and multiplicative relative risk in the two-stage clonal expansion model of carcinogenesis. AN - 16047976; 2614155 AB - The effects of exposure to two carcinogens are explored within the context of the two-stage clonal expansion model of carcinogenesis. This biologically based model provides a useful framework for the quantitative description of carcinogenesis, and for defining carcinogenic agents that act as initiators, promoters, and completers. This paper addresses the combined effects of simultaneous lifetime exposure to two carcinogens as well as nonoverlapping partial lifetime exposure to each agent. Whereas the age-specific relative risk for exposure to two initiators or two completers is additive, a multiplicative relative risk model holds for exposure to an initiator and a completer, or to a promoter and a completer. Exposure to two promoters yields supra-multiplicative relative risk. JF - Risk Analysis AU - Kodell, R L AU - Krewski, D AU - Zielinski, J M AD - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 483 EP - 490 VL - 11 IS - 3 SN - 0272-4332, 0272-4332 KW - carcinogenesis KW - Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - genotoxicity KW - mathematical models KW - risk assessment KW - H SM5.2:DATA ANALYSIS KW - R2 23060:Medical and environmental health KW - R2 23010:General: Models, forecasting KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16047976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Additive+and+multiplicative+relative+risk+in+the+two-stage+clonal+expansion+model+of+carcinogenesis.&rft.au=Kodell%2C+R+L%3BKrewski%2C+D%3BZielinski%2C+J+M&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-01-01&rft.volume=11&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - risk assessment; mathematical models; genotoxicity ER - TY - JOUR T1 - Genotoxicity of diesel-exhaust particles dispersed in simulated pulmonary surfactant. AN - 16047925; 2606228 AB - Diesel-exhaust particles from two sources were dispersed in aqueous mixtures of dipalmitoyl phosphatidyl choline, a major component of pulmonary surfactant, and were tested for genotoxicity. Diesel samples from the same sources were extracted with dichloromethane and transferred into dimethyl sulfoxide and subjected to the same assays. Both types of extractions yielded similar results in both the Salmonella mutagenicity assay and the sister-chromatid exchange assay using V79 cells. After separation of the samples into supernatant and sediment fractions, the activity of both diesel samples was shown to reside exclusively in the supernatant fraction for the solvent-extracted samples, and exclusively in the sedimented fraction for surfactant dispersed samples. JF - Mutation Research AU - Keane, MJ AU - Xing, S-G AU - Harrison, J C AU - Ong, T AU - Wallace, W E AD - Cent. Dis. Control, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 233 EP - 238 VL - 260 IS - 3 SN - 0027-5107, 0027-5107 KW - particles KW - fuels KW - diesel KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - mutation KW - sister chromatid exchange KW - genotoxicity KW - exhausts KW - Ames test KW - lung KW - surfactants KW - H SM5.8.2:CHEMICALS (CORROSION) KW - X 24155:Biochemistry KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16047925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Genotoxicity+of+diesel-exhaust+particles+dispersed+in+simulated+pulmonary+surfactant.&rft.au=Keane%2C+MJ%3BXing%2C+S-G%3BHarrison%2C+J+C%3BOng%2C+T%3BWallace%2C+W+E&rft.aulast=Keane&rft.aufirst=MJ&rft.date=1991-01-01&rft.volume=260&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - exhausts; mutation; genotoxicity; Ames test; sister chromatid exchange; lung; surfactants ER - TY - JOUR T1 - Nonisocyanate exposures in three flexible polyurethane manufacturing facilities. AN - 16033099; 2605960 AB - Workers were found to have respiratory and probably dermal exposure to methylene chloride in each facility. Traces of nitrogen dioxide and some aliphatic amines were evident. However, N-nitrosamines were not found. Exposure to thermal degradation products, polyurethane dust, and to flame retardants does not appear to be a problem under reasonable hygienic conditions. However, evidence for the existence of acrolein and acrylonitrile was found in one facility due to the thermal degradation of finished foam. Mutagenic activity, appearing only in the particulate fraction, appeared highest when the total isocyanate group air concentrations (TRIG) were also high. In one facility, the mutagenic activity was up to 75 times higher than the mutagenic activity of the outside air. The methods used to characterize each of the exposures are provided and the results are discussed. JF - Applied Occupational and Environmental Hygiene AU - Boeniger, M F AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 46226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 945 EP - 952 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - polyurethane KW - toluene diisocyanate KW - Pollution Abstracts; Health & Safety Science Abstracts KW - dust KW - occupational health KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI8.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16033099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Nonisocyanate+exposures+in+three+flexible+polyurethane+manufacturing+facilities.&rft.au=Boeniger%2C+M+F&rft.aulast=Boeniger&rft.aufirst=M&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; dust ER - TY - JOUR T1 - Effects of thermal environment and chemical protective clothing on work tolerance, physiological responses, and subjective ratings. AN - 16032930; 2601867 AB - This study examined the physiological and subjective responses of nine healthy men who performed work while wearing two types of protective ensembles in each of three thermal environments. The subjects, all experienced with the use of protective ensembles, each performed low intensity treadmill exercise (23% of VO sub(2) max while not wearing a Self-Contained Breathing Apparatus (SCBA) or protective clothing) under six experimental conditions: two ensembles during exposure to 'cool", "neutral", and "hot" environments. Each test was intended to continue for 120 min; however the duration and number of work/rest periods within the testing session varied according to the specific responses of each individual. JF - Ergonomics AU - White, M K AU - Hodous, T K AU - Vercruyssen, M AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 445 EP - 457 VL - 34 IS - 4 SN - 0014-0139, 0014-0139 KW - protective clothing KW - Health & Safety Science Abstracts KW - physiology KW - ergonomics KW - temperature KW - H SI6.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16032930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Effects+of+thermal+environment+and+chemical+protective+clothing+on+work+tolerance%2C+physiological+responses%2C+and+subjective+ratings.&rft.au=White%2C+M+K%3BHodous%2C+T+K%3BVercruyssen%2C+M&rft.aulast=White&rft.aufirst=M&rft.date=1991-01-01&rft.volume=34&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - physiology; temperature; ergonomics ER - TY - JOUR T1 - Control of wood dust from disc sanders. AN - 16032539; 2605704 AB - Association between nasal cancer and other health effects and occupations involving exposure to wood dust has been clearly established in the literature. This article reports on the research that has been conducted by scientists at the National Institute for Occupational Safety and Health (NIOSH) to reduced wood dust emissions from large-diameter disc sanders. An air jet stripper system was developed to be used in conjunction with existing local exhaust ventilation to reduce dust emissions. The system consists of a set of jets located inside the local exhaust hood. The jets are supplied with pressurized air. The control system, combined with currently existing controls, reduced wood dust emissions (area and breathing zone) by an average of 60 percent. Laboratory results were confirmed by field tests conducted at a wood furniture manufacturing plant. The control system does not interfere with the worker's activity, requires minimum maintenance, and is inexpensive to install and operate. JF - Applied Occupational & Environmental Hygiene AU - Hampl, V AU - Johnston, O E AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 938 EP - 944 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - wood KW - Pollution Abstracts; Health & Safety Science Abstracts KW - air stripping KW - occupational health KW - control systems KW - ventilation KW - emission control KW - dust KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI0.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16032539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Control+of+wood+dust+from+disc+sanders.&rft.au=Hampl%2C+V%3BJohnston%2C+O+E&rft.aulast=Hampl&rft.aufirst=V&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; occupational health; air stripping; ventilation; emission control; control systems ER - TY - JOUR T1 - Analysis of urine to monitor exposures to benzidine, o-dianisidine, o-tolidine, and 4,4'-methylenedianiline. AN - 16029876; 2605956 AB - Aromatic diamines have great potential for dermal absorption as an exposure route. Also, the body exhibits the ability to reductively cleave an azo dye to its corresponding aromatic diamine. These factors have demonstrated the need for biological monitoring to complement environmental monitoring when assessing occupational exposures to these compounds. This is especially important since certain aromatic diamines are known or are potential human carcinogens. Therefore, a sampling and analytical procedure for the measurement of benzidine, o-dianisidine, o-tolidine, and 4,4'-methylenedianiline in urine was developed for use in industrial hygiene investigations. After hydrolysis of urine metabolites, the free diamines are isolated using a C sub(18) solid sorbent. The free diamines are eluted, concentrated, and injected into a high-performance liquid chromatography system. JF - Applied Occupational and Environmental Hygiene AU - Neumeister, CE AD - U.S. DHHS, Public Health Serv., NIOSH, Div. Phys. Sci. and Eng., Meas. Res. Support Branch, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 953 EP - 958 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - metabolites KW - absorption KW - Health & Safety Science Abstracts KW - aromatic compounds KW - hydrolysis KW - urine KW - occupational health KW - H SI0.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16029876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Analysis+of+urine+to+monitor+exposures+to+benzidine%2C+o-dianisidine%2C+o-tolidine%2C+and+4%2C4%27-methylenedianiline.&rft.au=Neumeister%2C+CE&rft.aulast=Neumeister&rft.aufirst=CE&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - aromatic compounds; hydrolysis; urine; occupational health ER - TY - JOUR T1 - Cost-effective radiator repair ventilation control. AN - 16027387; 2605884 AB - This article describes a cost-effective ventilation enclosure made of a flexible silicon sheet reinforced by fibrous glass that forms a tent-like structure over the water bath that is used to leak test radiators. An opening in the front of the enclosure permits the mechanic to repair the radiator inside the enclosure. A propeller fan mounted in the rear (outside wall) of the enclosure exhausts air at a rate of 3400 m super(3)/hr (2000 cfm), producing an air flow of 1 m/sec (200 fpm) through the enclosure opening. The authors are not aware of any ventilation hood of this type that has previously been designed or installed in radiator repair shops. JF - Applied Occupational & Environmental Hygiene AU - Goldfield, J AU - Sheehy, J W AU - Gunter, B J AU - Daniels, W J AD - Div. Phys. Sci. and Eng., NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 959 EP - 965 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - cost benefit analysis KW - radiators KW - repair KW - Health & Safety Science Abstracts KW - ventilation KW - occupational health KW - H SI8.9.3:COLD UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16027387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Cost-effective+radiator+repair+ventilation+control.&rft.au=Goldfield%2C+J%3BSheehy%2C+J+W%3BGunter%2C+B+J%3BDaniels%2C+W+J&rft.aulast=Goldfield&rft.aufirst=J&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ventilation; occupational health ER - TY - JOUR T1 - Air concentrations of TDI and total reactive isocyanate group in three flexible polyurethane manufacturing facilities. AN - 16020741; 2591005 AB - In-depth industrial hygiene surveys were conducted in two large facilities manufacturing molded flexible foam and one facility manufacturing and finishing flexible slab foam. These surveys were performed to support a retrospective, cohort, mortality study of workers that were potentially exposed to toluene diisocyanate (TDI). The air sample results show that isocyanate concentrations differed from plant to plant and were probably dependent on the operations performed, engineering controls, and the physical layout of the plant. In the two molded foam facilities, many of the personal exposures were above 35 mu g/m super(3), as had been recommended by the National Institute for Occupational Safety and Health (NIOSH). As expected, pouring line workers were generally more exposed than finishing workers. JF - Applied Occupational and Environmental Hygiene AU - Boeniger, M F AD - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 853 EP - 858 VL - 6 IS - 6 SN - 1047-322X, 1047-322X KW - occupational health KW - toluene diisocyanate KW - Health & Safety Science Abstracts; Pollution Abstracts KW - chemical industry KW - surveys KW - air sampling KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI6.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16020741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Air+concentrations+of+TDI+and+total+reactive+isocyanate+group+in+three+flexible+polyurethane+manufacturing+facilities.&rft.au=Boeniger%2C+M+F&rft.aulast=Boeniger&rft.aufirst=M&rft.date=1991-01-01&rft.volume=6&rft.issue=6&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - surveys; air sampling; chemical industry ER - TY - JOUR T1 - Silicosis and lung cancer in North Carolina dusty trades workers. AN - 16014923; 2583037 AB - Since 1940, 760 cases of silicosis have been diagnosed as part of the State of North Carolina's (NC) pneumoconiosis surveillance program for dusty trades workers. Vital status was ascertained through 1983 of 714 cases that had been diagnosed since 1940 and death certificates were obtained for 546 of the 550 deceased. Mortality from tuberculosis, cancer of the intestine and lung, pneumonia, bronchitis, emphysema, asthma, pneumoconiosis, and kidney disease was significantly increased in whites. Mortality from tuberculosis, ischemic heart disease, and pneumoconiosis was significantly increased in non-whites. JF - American Journal of Industrial Medicine AU - Amandus, HE AU - Shy, C AU - Wing, S AU - Blair, A AU - Heineman, E F AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 57 EP - 70 VL - 20 IS - 1 SN - 0271-3586, 0271-3586 KW - lung KW - occupational health KW - North Carolina KW - asbestos KW - foundries KW - respiratory diseases KW - tuberculosis KW - occupational hazards KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - mining KW - USA, North Carolina KW - coal KW - silicosis KW - dust KW - cancer KW - pneumoconiosis KW - X 24240:Miscellaneous KW - H SI2.8.7:DUST KW - H SM10.21:CANCER KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16014923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Silicosis+and+lung+cancer+in+North+Carolina+dusty+trades+workers.&rft.au=Amandus%2C+HE%3BShy%2C+C%3BWing%2C+S%3BBlair%2C+A%3BHeineman%2C+E+F&rft.aulast=Amandus&rft.aufirst=HE&rft.date=1991-01-01&rft.volume=20&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA, North Carolina; cancer; silicosis; asbestos; dust; coal; mining; foundries; pneumoconiosis; respiratory diseases; tuberculosis; occupational hazards ER - TY - PAT T1 - Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds. AN - 16006161; 2578407 AB - A method of treating HIV infection comprises administering about 0.4 to 25.6 mg/kg/day of 2',3'-dideoxyinosine in combination with a member selected from the group consisting of 3'-azido-2',3'-dideoxythymidine, acyclovir, gancyclovir, pentamidine and ribovirin. AU - Yarchoan, R AU - Mitsuya, H AU - Broder, S PY - 1991 IS - US Patent 5,026,687 KW - patents KW - 2',3'-dideoxyinosine KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antiviral agents KW - human immunodeficiency virus KW - acquired immune deficiency syndrome KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16006161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Treatment+of+human+retroviral+infections+with+2%27%2C3%27-dideoxyinosine+alone+and+in+combination+with+other+antiviral+compounds.&rft.au=Yarchoan%2C+R%3BMitsuya%2C+H%3BBroder%2C+S&rft.aulast=Yarchoan&rft.aufirst=R&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/45; Int. Cl. A61K 31/70. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Studies on three structurally related phenylenediamines with the mouse micronucleus assay system. AN - 15981036; 2551010 AB - Three structurally related compounds, 4-chloro-o-phenylenediamine (COP), 4-nitro-o-phenylenediamine (NOP) and p-phenylenediamine dihydrochloride (PPD), are used in fur dyes, inks and hair coloring formulations. COP has been reported to be carcinogenic in both rats and mice. NOP and PPD are non-carcinogens, but have consistently tested positive in short-term in vitro genotoxicity assays. Studies were undertaken to evaluate their genotoxicity with the in vivo mouse bone-marrow micronucleus assay. Five CD-1 male mice per dose were injected i.p. with the compounds and sacrificed at intervals of 24, 48 and 72 h. 2000 cells were scored per animal to determine the frequency of micronucleated-polychromatic erythrocytes (MPCE). COP induced significant dose-related increases in MPCE over the 3 doses tested at each of the sampling intervals. JF - Mutation Research AU - Soler-Niedziela, L AU - Shi, X AU - Nath, J AU - Ong, T AD - Microbiol. Sect., NIOSH-ALOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 43 EP - 48 VL - 259 IS - 1 SN - 0027-5107, 0027-5107 KW - mice KW - assays KW - systems KW - mutagenicity testing KW - 4-chloro-o-phenylenediamine KW - p-phenylenediamine dihydrochloride KW - 4-nitro-o-phenylenediamine KW - Toxicology Abstracts; Genetics Abstracts KW - micronuclei KW - G 07398:GENERAL KW - X 24155:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15981036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Studies+on+three+structurally+related+phenylenediamines+with+the+mouse+micronucleus+assay+system.&rft.au=Soler-Niedziela%2C+L%3BShi%2C+X%3BNath%2C+J%3BOng%2C+T&rft.aulast=Soler-Niedziela&rft.aufirst=L&rft.date=1991-01-01&rft.volume=259&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - micronuclei ER - TY - JOUR T1 - Pathogenicity of nonstressed, heat-stressed, and resuscitated Listeria monocytogenes 1A1 cells. AN - 15974192; 2545723 AB - The pathogenicity of nonstressed, heat-stressed, and resuscitated cells of Listeria monocytogenes 1A1 was assayed in immunocompromised mice. Cells were stressed by heating them at 56 degree C for 20 min and were resuscitated by incubation in tryptic soy broth at 25 degree C. A dose of 10 super(2) nonstressed and resuscitated cells per mouse was required for pathogenicity; a dose of 10 super(4) heat-stressed cells per mouse was considerably less pathogenic. Loss of hemolytic activity accompanied the decreased virulence. JF - Applied and Environmental Microbiology AU - McCarthy, SA AD - Fish. Res. Branch, FDA, Dauphin Island, AL 36528, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 2389 EP - 2391 VL - 57 IS - 8 SN - 0099-2240, 0099-2240 KW - Listeria monocytogenes KW - effects on KW - pathogenicity KW - mice KW - Microbiology Abstracts B: Bacteriology KW - heat treatments KW - listeriosis KW - bioassays KW - hemolysis KW - immunocompromised hosts KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15974192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Pathogenicity+of+nonstressed%2C+heat-stressed%2C+and+resuscitated+Listeria+monocytogenes+1A1+cells.&rft.au=McCarthy%2C+SA&rft.aulast=McCarthy&rft.aufirst=SA&rft.date=1991-01-01&rft.volume=57&rft.issue=8&rft.spage=2389&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - heat treatments; hemolysis; bioassays; immunocompromised hosts; listeriosis ER - TY - PAT T1 - Probe to identify enteroinvasive E. coli and Shigella species. AN - 15969037; 2535289 AU - Lampel, KA AU - Jagow, JA PY - 1991 IS - US Patent 5,041,372 KW - patents KW - virulence KW - Escherichia coli KW - Shigella KW - nucleotide sequence KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15969037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Probe+to+identify+enteroinvasive+E.+coli+and+Shigella+species.&rft.au=Lampel%2C+KA%3BJagow%2C+JA&rft.aulast=Lampel&rft.aufirst=KA&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/6; Int. Cl. C12Q 1/68, 1/24; G01N 33/566; C07H 15/12. N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Statistical evaluation of exposure assessment strategies. AN - 15958557; 2523680 AB - It is well known that exposure measurement error or misclassification can bias an epidemiologic risk assessment. Accordingly, it is useful to have methods of assessing the degree of error in exposure assessments. This paper proposes statistical evaluation techniques for two types of exposure assessment strategies: categorization of exposure and estimation of actual personal exposure levels (with particular attention to the latter). Categorization of exposure is generally done in one of the two ways: ordinal but nonquantitative grouping or quantitative exposure intervals. Estimation of actual exposure levels is most often done in the form of job-by-year exposure matrices and somewhat less often by exposure prediction models. The nature of uncertainty inherent with each of these approaches is described. JF - Applied Occupational & Environmental Hygiene AU - Hornung, R W Y1 - 1991 PY - 1991 DA - 1991 SP - 516 EP - 520 VL - 6 IS - 6 KW - epidemiology KW - Health & Safety Science Abstracts; Pollution Abstracts KW - statistical analysis KW - occupational health KW - risk assessment KW - H SI0.2:DATA ANALYSIS KW - H SM3.3:HAZARD DETERMINATION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15958557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Statistical+evaluation+of+exposure+assessment+strategies.&rft.au=Hornung%2C+R+W&rft.aulast=Hornung&rft.aufirst=R&rft.date=1991-01-01&rft.volume=6&rft.issue=6&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Ventilation control of lead in indoor firing ranges: Inlet configuration and booth and fluctuating flow contributions. AN - 15930880; 2506640 AB - Workers in and, in some cases, users of indoor firing ranges continue to receive overexposures to airborne lead levels in spite of efforts to produce smooth and ample ventilation. Studies of firing ranges by researchers for the National Institute for Occupational Safety and Health (NIOSH) and others have shown that only on very infrequent occasions will the ventilation airflow adequately control lead exposures. Some firing ranges use only ventilation to control lead exposures, and these have stimulated a search for the ventilation system elements that will ensure successful control. Substitution of nonlead bullets and primer as a control means has shown some success but has not gained widespread acceptance because of its effects on the accuracy, range, and reliability of firearms. JF - American Industrial Hygiene Association Journal AU - Crouch, K G AU - Peng, T AU - Murdock, D J AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 81 EP - 91 VL - 52 IS - 2 SN - 0002-8894, 0002-8894 KW - ventilation KW - firing ranges KW - monitoring measurements KW - Health & Safety Science Abstracts; Pollution Abstracts KW - lead KW - air quality KW - flow rates KW - indoor environments KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI11.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15930880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Ventilation+control+of+lead+in+indoor+firing+ranges%3A+Inlet+configuration+and+booth+and+fluctuating+flow+contributions.&rft.au=Crouch%2C+K+G%3BPeng%2C+T%3BMurdock%2C+D+J&rft.aulast=Crouch&rft.aufirst=K&rft.date=1991-01-01&rft.volume=52&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - indoor environments; lead; air quality; flow rates ER - TY - JOUR T1 - Evaluation of a new solid sorbent sampler for alveolar methylene chloride used in tandem with a bag for sampling alveolar carbon monoxide. AN - 15916867; 2501466 AB - A method for sampling and analysis of methylene chloride and carbon monoxide in alveolar air is described. The method employs a three-section bed of charcoal cloth sorbent for the determination of methylene chloride concentrations and a bag downstream of the solid sorbent sampler for determination of carbon monoxide concentrations. The method was evaluated in a study to assess the level of exposure to and uptake of methylene chloride by 14 furniture strippers. Alveolar breath samples obtained from these workers were analyzed for methylene chloride and carbon monoxide. Venous blood samples also were obtained from the furniture strippers and analyzed for methylene chloride and carboxyhemoglobin. All methylene chloride samples were analyzed by gas chromatography with flame ionization detection. Breath carbon monoxide was analyzed using an electrochemical detector (Ecolyzer). Blood carboxyhemoglobin levels were determined with a CO-Oximeter. JF - Applied Occupational and Environmental Hygiene AU - Glaser, R A AU - Arnold, JE AU - McCammon, CS Jr AU - Phipps, F C AD - NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 380 EP - 388 VL - 6 IS - 5 SN - 1047-322X, 1047-322X KW - carbon monoxide KW - furniture KW - methylene chloride KW - Pollution Abstracts; Health & Safety Science Abstracts KW - blood analysis KW - occupational health KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI1.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15916867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+a+new+solid+sorbent+sampler+for+alveolar+methylene+chloride+used+in+tandem+with+a+bag+for+sampling+alveolar+carbon+monoxide.&rft.au=Glaser%2C+R+A%3BArnold%2C+JE%3BMcCammon%2C+CS+Jr%3BPhipps%2C+F+C&rft.aulast=Glaser&rft.aufirst=R&rft.date=1991-01-01&rft.volume=6&rft.issue=5&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - blood analysis; occupational health ER - TY - JOUR T1 - Role of FDA in establishing tolerable levels for dioxin and PCBs in aquatic organisms. AN - 15915002; 2499386 AB - When fishery products shipped in interstate commerce contain an environmental contaminant that presents a potential threat to public health, the Food and Drug Administration (FDA) undertakes regulatory steps to minimize exposure. These range from seizure of the product to formal rule-making to establish a limit. The basic provision of the Food, Drug, and Cosmetic (FD&C) Act by which the agency deals with environmental contaminants in the food supply is section 402(a)(1), which deals with poisonous and deleterious substances. "Action levels" are administrative guidelines or instructions to the agency field units that define the extent of contamination at which the agency may regard food as adulterated. Except for polychlorinated biphenyls, for which a tolerance is established by regulation, FDA has controlled contaminants in aquatic organisms by using action levels. Under section 406 of the FD&C act, the agency can establish tolerances for unavoidably added poisonous or deleterious substances. This allows the agency to consider the extent to which a contaminant is unavoidable in food while it limits exposure to protect public health. Section 406 requires that the tolerance be established by assessing several factors, including risk. JF - Journal of Toxicology and Environmental Health AU - Boyer, I J AU - Kokoski, CJ AU - Bolger, P M AD - Contam. Team, Stand. and Monit., HFF-156, Branch Div. Toxicol. Rev. and Eval., FDA, 200 C St. SW, Washington, DC 20204, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 93 EP - 101 VL - 33 IS - 1 SN - 0093-4108, 0093-4108 KW - Food and Drug Administration KW - PCB KW - PCB compounds KW - TCDD KW - food contamination KW - government policy KW - human food KW - pollution legislation KW - ASFA 3: Aquatic Pollution & Environmental Quality; Risk Abstracts; Pollution Abstracts; Toxicology Abstracts KW - fishery products KW - legislation KW - standards KW - aquatic organisms KW - seafood KW - X 24120:Food, additives & contaminants KW - R2 23090:Policy and planning KW - X 24230:Legislation & recommended standards KW - P 9000:ENVIRONMENTAL ACTION KW - X 24156:Environmental impact KW - Q5 08505:Prevention and control KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15915002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Role+of+FDA+in+establishing+tolerable+levels+for+dioxin+and+PCBs+in+aquatic+organisms.&rft.au=Boyer%2C+I+J%3BKokoski%2C+CJ%3BBolger%2C+P+M&rft.aulast=Boyer&rft.aufirst=I&rft.date=1991-01-01&rft.volume=33&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - standards; pollution legislation; aquatic organisms; fishery products; seafood; legislation; human food; food contamination; government policy; TCDD; PCB compounds ER - TY - JOUR T1 - Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract. AN - 15909973; 2497444 AB - Human intestinal microbial flora were screened for their abilities to reduce nitroaromatic compounds by growing them on brain heart infusion agar plates containing 1-nitropyrene. Bacteria metabolizing 1-nitropyrene, detected by the appearance of clear zones around the colonies, were identified as Clostridium leptum, Clostridium paraputrificum, Clostridium clostridiiforme , another Clostridium sp., and a Eubacterium sp. These bacteria produced aromatic amines from nitroaromatic compounds, as shown by thin-layer chromatography, high-pressure liquid chromatography, and biochemical tests. Menadione and o-iodosobenzoic acid inhibited nitroreductase activity in all of the isolates, indicating the involvement of sulfhydryl groups in the active site of the enzyme. The optimum pH for nitroreductase activity was 8.0. Only the Clostridium sp. required added flavin adenine dinucleotide for nitroreductase activity. The nitroreductases were constitutive and extracellular. JF - Applied and Environmental Microbiology AU - Rafii, F AU - Franklin, W AU - Heflich, R H AU - Cerniglia, CE AD - Div. Microbiol., Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 962 EP - 968 VL - 57 IS - 4 SN - 0099-2240, 0099-2240 KW - Clostridium KW - activity KW - nitroreductase KW - 1-nitropyrene KW - intestinal microflora KW - nitroaromatic compounds KW - Pollution Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Eubacterium KW - biodegradation KW - enzymes KW - reduction KW - A 01016:Microbial degradation KW - P 6000:TOXICOLOGY AND HEALTH KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15909973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Reduction+of+nitroaromatic+compounds+by+anaerobic+bacteria+isolated+from+the+human+gastrointestinal+tract.&rft.au=Rafii%2C+F%3BFranklin%2C+W%3BHeflich%2C+R+H%3BCerniglia%2C+CE&rft.aulast=Rafii&rft.aufirst=F&rft.date=1991-01-01&rft.volume=57&rft.issue=4&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Eubacterium; reduction; biodegradation; enzymes; intestinal microflora ER - TY - JOUR T1 - Exposure of workers engaged in furniture stripping to methylene chloride as determined by environmental and biological monitoring. AN - 15901940; 2501437 AB - In response to reports of adverse reproductive effects of exposure to methylene chloride, investigators from the National Institute for Occupational Safety and Health conducted an industrial hygiene survey of a cohort of 14 furniture strippers exposed to methylene chloride in five furniture stripping shops. Both environmental and biological monitoring of the workers were conducted. Personal time-weighted average (TWA) concentrations of methylene chloride were determined. Pre- and postshift alveolar breath samples were analyzed for carbon monoxide and methylene chloride. Postshift venous blood samples were analyzed for carboxyhemoglobin and methylene chloride. Methylene chloride TWA exposure of the workers ranged from 15 to 366 ppm, while exposures to other solvents were well below their respective evaluation criteria. The highest average exposures to methylene chloride by job category were strippers (191 ppm) followed by washers (145 ppm) and refinishers (31 ppm). Postexposure breath concentrations of methylene chloride ranged from 2.3 to 167 ppm, while blood concentrations ranged from 0.1 to 8.8 ppm. JF - Applied Occupational and Environmental Hygiene AU - McCammon, CS Jr AU - Glaser, R A AU - Wells, V E AU - Phipps, F C AU - Halperin, W E AD - NIOSH, Denver Reg. Off., Denver, CO, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 371 EP - 379 VL - 6 IS - 5 SN - 1047-322X, 1047-322X KW - methylene chloride KW - furniture KW - biology KW - Pollution Abstracts; Health & Safety Science Abstracts KW - blood analysis KW - occupational health KW - environmental monitoring KW - solvents KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI1.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15901940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Exposure+of+workers+engaged+in+furniture+stripping+to+methylene+chloride+as+determined+by+environmental+and+biological+monitoring.&rft.au=McCammon%2C+CS+Jr%3BGlaser%2C+R+A%3BWells%2C+V+E%3BPhipps%2C+F+C%3BHalperin%2C+W+E&rft.aulast=McCammon&rft.aufirst=CS&rft.date=1991-01-01&rft.volume=6&rft.issue=5&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - environmental monitoring; solvents; blood analysis; occupational health ER - TY - JOUR T1 - Electromagnetic field exposure and leukemia mortality in the United States. AN - 15901455; 2487768 AB - Reports of excess leukemia mortality or morbidity among men employed in "electrical" occupations who have potential exposures to a wide variety of electromagnetic radiation, including 60 Hz fields, have been described for populations in Washington State 1950 to 1979, California 1959 to 1961, Wisconsin 1963 to 1978, Massachusetts 1971 to 1973, United Kingdom 1970 to 1973, South East England 1961 to 1979, and New Zealand 1979 to 1983. A review article used a meta-analysis to compare 11 epidemiologic reports and found a statistically significant summary relative risk of 1.2 for total leukemias for the 12 electrical occupations. JF - J. OCCUP. MED. AU - Robinson, C F AU - Lalich, N R AU - Burnett, CA AU - Sestito, J P AU - Frazier, T M AD - NIOSH, Mail Stop R-18, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 160 EP - 162 VL - 33 IS - 2 SN - 0096-1736, 0096-1736 KW - electromagnetic radiation KW - man KW - United States KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - electromagnetic fields KW - leukemia KW - occupational exposure KW - USA KW - mortality KW - H SM9.4:ACCIDENT INVESTIGATION KW - X 24210:Radiation & radioactive materials KW - P 8000:RADIATION KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.27:LEUKEMIA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15901455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Electromagnetic+field+exposure+and+leukemia+mortality+in+the+United+States.&rft.au=Robinson%2C+C+F%3BLalich%2C+N+R%3BBurnett%2C+CA%3BSestito%2C+J+P%3BFrazier%2C+T+M&rft.aulast=Robinson&rft.aufirst=C&rft.date=1991-01-01&rft.volume=33&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA; leukemia; occupational exposure; mortality; electromagnetic fields; man ER - TY - JOUR T1 - Limitations in the use of particle size-selective sampling criteria in occupational epidemiology. AN - 15899751; 2472388 AB - The American Conference of Governmental Industrial Hygienists (ACGIH) and the International Standards Organization (ISO) have both recently proposed similar sets of particulate sampling criteria. The criteria describe sample device collection efficiency, as a function of particle size, for inspirable, thoracic, and respirable particulate mass. The collection efficiency curves do not match the lung deposition curves at all particle sizes which leads to a bias between measured particulate (exposure) and deposited particulate (dose). This bias, as a function of particulate size distribution, was examined for both the ACGIH and ISO proposed curves. Results indicate that the amount of bias varies with both geometric mean (mass median aerodynamic diameter) and geometric standard deviation. JF - Applied Occupational & Environmental Hygiene AU - Hewett, P AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 290 EP - 300 VL - 6 IS - 4 SN - 1047-322X, 1047-322X KW - particle size KW - Am. Conf. Gov. Ind. Hyg. KW - dose response effects KW - Health & Safety Science Abstracts; Pollution Abstracts KW - respiration KW - epidemiology KW - occupational health KW - air sampling KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15899751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Limitations+in+the+use+of+particle+size-selective+sampling+criteria+in+occupational+epidemiology.&rft.au=Hewett%2C+P&rft.aulast=Hewett&rft.aufirst=P&rft.date=1991-01-01&rft.volume=6&rft.issue=4&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; air sampling; respiration; epidemiology ER - TY - JOUR T1 - Evidence for behavioral teratogenicity in humans. AN - 15889891; 2476297 AB - Central to both the scientific development of behavioral teratology and the attention paid to his field as an important area of study is establishing that prenatal exposure of pregnant females to exogenous agents leads to neurobehavioral disorders in their offspring. This tenet may not be questioned by the majority of toxicologists, but others may not be convinced. This paper serves as a brief review of the accumulated evidence that prenatal exposure to a number of drugs and environmental/industrial agents produces behavioral disorders in human infants. JF - Journal of Applied Toxicology AU - Nelson, B K AD - Div. Biomed. and Behav. Sci., NIOSH C-24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 33 EP - 37 VL - 11 IS - 1 SN - 0260-437X, 0260-437X KW - toxicants KW - behaviour KW - Toxicology Abstracts KW - infants KW - teratogenicity KW - man KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15889891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Evidence+for+behavioral+teratogenicity+in+humans.&rft.au=Nelson%2C+B+K&rft.aulast=Nelson&rft.aufirst=B&rft.date=1991-01-01&rft.volume=11&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - teratogenicity; infants; man ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945165 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945112 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945061 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945060 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945058 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945046 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945030 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519944369 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519944336 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519944289 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519944270 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519944167 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 8 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Diagnostic Interviews for Assessment: Background, Reliability, Validity AN - 1474334580 JF - Alcohol Health and Research World AU - Hasin, Deborah S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 293 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Diagnostic+Interviews+for+Assessment%3A+Background%2C+Reliability%2C+Validity&rft.au=Hasin%2C+Deborah+S&rft.aulast=Hasin&rft.aufirst=Deborah&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Use and Abuse: Some Findings from the National Adolescent Student Health Survey AN - 1474334562 JF - Alcohol Health and Research World AU - Windle, Michael Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Use+and+Abuse%3A+Some+Findings+from+the+National+Adolescent+Student+Health+Survey&rft.au=Windle%2C+Michael&rft.aulast=Windle&rft.aufirst=Michael&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Expectancies and Sexuality AN - 1474334533 JF - Alcohol Health and Research World AU - Goldman, Mark S AU - Roehrich, Laurie Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 126 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Expectancies+and+Sexuality&rft.au=Goldman%2C+Mark+S%3BRoehrich%2C+Laurie&rft.aulast=Goldman&rft.aufirst=Mark&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Finer Points About New Treatment Approaches AN - 1474321944 JF - Alcohol Health and Research World AU - Huey, Elizabeth D Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 219 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Finer+Points+About+New+Treatment+Approaches&rft.au=Huey%2C+Elizabeth+D&rft.aulast=Huey&rft.aufirst=Elizabeth&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - On Defining Alcoholism AN - 1474321816 JF - Alcohol Health and Research World AU - Keller, Mark AU - Doria, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 253 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=On+Defining+Alcoholism&rft.au=Keller%2C+Mark%3BDoria%2C+John&rft.aulast=Keller&rft.aufirst=Mark&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Developing Standardized Measures of Treatment Outcome AN - 1474321754 JF - Alcohol Health and Research World AU - Frawley, P Joseph Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 201 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Developing+Standardized+Measures+of+Treatment+Outcome&rft.au=Frawley%2C+P+Joseph&rft.aulast=Frawley&rft.aufirst=P&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Models of Vulnerability to Psychopathology in Children of Alcoholics: An Overview AN - 1474321728 JF - Alcohol Health and Research World AU - Johnson, Jeannette L AU - Sher, Kenneth J AU - Rolf, Jon E Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 32 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Models+of+Vulnerability+to+Psychopathology+in+Children+of+Alcoholics%3A+An+Overview&rft.au=Johnson%2C+Jeannette+L%3BSher%2C+Kenneth+J%3BRolf%2C+Jon+E&rft.aulast=Johnson&rft.aufirst=Jeannette&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Sexuality and Stigma: The Alcoholic Woman AN - 1474321679 JF - Alcohol Health and Research World AU - Blume, Sheila B Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 139 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Sexuality+and+Stigma%3A+The+Alcoholic+Woman&rft.au=Blume%2C+Sheila+B&rft.aulast=Blume&rft.aufirst=Sheila&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genetic Contributions to Alcoholism Diagnosis AN - 1474321671 JF - Alcohol Health and Research World AU - Pickens, Roy W AU - Svikis, Dace S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 272 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genetic+Contributions+to+Alcoholism+Diagnosis&rft.au=Pickens%2C+Roy+W%3BSvikis%2C+Dace+S&rft.aulast=Pickens&rft.aufirst=Roy&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - OSAP College Drinking Campaign - "Put on the Brakes: Take a Look at College Drinking!" AN - 1474321632 JF - Alcohol Health and Research World AU - Eigen, Lewis D AU - Quinlan, Joan W Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 87 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=OSAP+College+Drinking+Campaign+-+%22Put+on+the+Brakes%3A+Take+a+Look+at+College+Drinking%21%22&rft.au=Eigen%2C+Lewis+D%3BQuinlan%2C+Joan+W&rft.aulast=Eigen&rft.aufirst=Lewis&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Reports The Economic Cost of Alcohol Abuse AN - 1474321583 JF - Alcohol Health and Research World AU - Rice, Dorothy P AU - Kelman, Sander AU - Miller, Leonard S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 307 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Reports+The+Economic+Cost+of+Alcohol+Abuse&rft.au=Rice%2C+Dorothy+P%3BKelman%2C+Sander%3BMiller%2C+Leonard+S&rft.aulast=Rice&rft.aufirst=Dorothy&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Encouraging Collaboration Between Research and Clinical Practice in Alcohol and Other Drug Abuse Treatment AN - 1474321530 JF - Alcohol Health and Research World AU - Woody, George E AU - McLellan, A Thomas AU - Alterman, Arthur A AU - O' Brien, Charles P Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 221 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Encouraging+Collaboration+Between+Research+and+Clinical+Practice+in+Alcohol+and+Other+Drug+Abuse+Treatment&rft.au=Woody%2C+George+E%3BMcLellan%2C+A+Thomas%3BAlterman%2C+Arthur+A%3BO%27+Brien%2C+Charles+P&rft.aulast=Woody&rft.aufirst=George&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Marketing New Ideas About Treatment AN - 1474321526 JF - Alcohol Health and Research World AU - Archer, Loran Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 213 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Marketing+New+Ideas+About+Treatment&rft.au=Archer%2C+Loran&rft.aulast=Archer&rft.aufirst=Loran&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474321512 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 99 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Normal Reproductive System AN - 1474321503 JF - Alcohol Health and Research World AU - Doria, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 101 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Normal+Reproductive+System&rft.au=Doria%2C+John&rft.aulast=Doria&rft.aufirst=John&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - What Is Alcoholism? Current Definitions and Diagnostic Criteria and Their Implications for Treatment AN - 1474321468 JF - Alcohol Health and Research World AU - Flavin, Daniel K AU - Morse, Robert M Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 266 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=What+Is+Alcoholism%3F+Current+Definitions+and+Diagnostic+Criteria+and+Their+Implications+for+Treatment&rft.au=Flavin%2C+Daniel+K%3BMorse%2C+Robert+M&rft.aulast=Flavin&rft.aufirst=Daniel&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Reports Sexuality and Women's Drinking: Findings from a U.S. National Study AN - 1474321463 JF - Alcohol Health and Research World AU - Wilsnack, Sharon C Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 147 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Reports+Sexuality+and+Women%27s+Drinking%3A+Findings+from+a+U.S.+National+Study&rft.au=Wilsnack%2C+Sharon+C&rft.aulast=Wilsnack&rft.aufirst=Sharon&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Relapse Prevention AN - 1474321408 JF - Alcohol Health and Research World AU - Annis, Helen M AU - Davis, Christine S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 204 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Relapse+Prevention&rft.au=Annis%2C+Helen+M%3BDavis%2C+Christine+S&rft.aulast=Annis&rft.aufirst=Helen&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - International Perspectives International Project on Adolescent Drinking AN - 1474321404 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 90 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=International+Perspectives+International+Project+on+Adolescent+Drinking&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 27 Prevalence of DSM - III - R Alcohol Abuse and Dependence: United States, 1988 AN - 1474321269 JF - Alcohol Health and Research World AU - Grant, Bridget F AU - Harford, Thomas C AU - Chou, Patricia AU - Pickering, Roger AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Noble, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 91 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+27+Prevalence+of+DSM+-+III+-+R+Alcohol+Abuse+and+Dependence%3A+United+States%2C+1988&rft.au=Grant%2C+Bridget+F%3BHarford%2C+Thomas+C%3BChou%2C+Patricia%3BPickering%2C+Roger%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BNoble%2C+John&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Practical Concerns for the Use of Assessment Instruments in a Clinical Treatment Setting AN - 1474321261 JF - Alcohol Health and Research World AU - Geller, Anne Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 186 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Practical+Concerns+for+the+Use+of+Assessment+Instruments+in+a+Clinical+Treatment+Setting&rft.au=Geller%2C+Anne&rft.aulast=Geller&rft.aufirst=Anne&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - A Comparison of Diagnostic Criteria: DSM - III - R, Proposed DSM - IV, and Proposed ICD - 10 AN - 1474321248 JF - Alcohol Health and Research World AU - Grant, Bridget F AU - Towle, Leland H Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 284 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=A+Comparison+of+Diagnostic+Criteria%3A+DSM+-+III+-+R%2C+Proposed+DSM+-+IV%2C+and+Proposed+ICD+-+10&rft.au=Grant%2C+Bridget+F%3BTowle%2C+Leland+H&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Interrelationship of Alcoholism Assessment and Treatment AN - 1474321238 JF - Alcohol Health and Research World AU - Allen, John P Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 178 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Interrelationship+of+Alcoholism+Assessment+and+Treatment&rft.au=Allen%2C+John+P&rft.aulast=Allen&rft.aufirst=John&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Early Developmental Factors and Risk for Alcohol Problems AN - 1474321187 JF - Alcohol Health and Research World AU - Zucker, Robert A AU - Fitzgerald, Hiram E Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 18 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Early+Developmental+Factors+and+Risk+for+Alcohol+Problems&rft.au=Zucker%2C+Robert+A%3BFitzgerald%2C+Hiram+E&rft.aulast=Zucker&rft.aufirst=Robert&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genetics of Alcoholism: Can and Should Youth at Risk Be Identified? AN - 1474321156 JF - Alcohol Health and Research World AU - Wilson, James R AU - Crowe, Lawson Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 11 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genetics+of+Alcoholism%3A+Can+and+Should+Youth+at+Risk+Be+Identified%3F&rft.au=Wilson%2C+James+R%3BCrowe%2C+Lawson&rft.aulast=Wilson&rft.aufirst=James&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Monitoring Treatment Outcomes AN - 1474321100 JF - Alcohol Health and Research World AU - Longabaugh, Richard Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 189 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Monitoring+Treatment+Outcomes&rft.au=Longabaugh%2C+Richard&rft.aulast=Longabaugh&rft.aufirst=Richard&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Refining the Link Between Research and Practice AN - 1474317721 JF - Alcohol Health and Research World AU - Caldwell, Fulton Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 175 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Refining+the+Link+Between+Research+and+Practice&rft.au=Caldwell%2C+Fulton&rft.aulast=Caldwell&rft.aufirst=Fulton&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Attention-Deficit Hyperactivity Disorder, Childhood Conduct Disorder, and Alcoholism: Is There an Association? AN - 1474317665 JF - Alcohol Health and Research World AU - Pihl, Robert O AU - Peterson, Jordan B Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 25 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Attention-Deficit+Hyperactivity+Disorder%2C+Childhood+Conduct+Disorder%2C+and+Alcoholism%3A+Is+There+an+Association%3F&rft.au=Pihl%2C+Robert+O%3BPeterson%2C+Jordan+B&rft.aulast=Pihl&rft.aufirst=Robert&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 29 Alcohol Use and Physically Risky Behavior Among Adolescents AN - 1474317641 JF - Alcohol Health and Research World AU - Caces, M Fe AU - Stinson, Frederick S AU - Harford, Thomas C Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 228 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+29+Alcohol+Use+and+Physically+Risky+Behavior+Among+Adolescents&rft.au=Caces%2C+M+Fe%3BStinson%2C+Frederick+S%3BHarford%2C+Thomas+C&rft.aulast=Caces&rft.aufirst=M&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Consumption and Sexual Risk-Taking in Adolescents AN - 1474317639 JF - Alcohol Health and Research World AU - Leigh, Barbara C AU - Morrison, Diane M Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 58 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Consumption+and+Sexual+Risk-Taking+in+Adolescents&rft.au=Leigh%2C+Barbara+C%3BMorrison%2C+Diane+M&rft.aulast=Leigh&rft.aufirst=Barbara&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol, Disinhibition, Sexual Arousal, and Deviant Sexual Behavior AN - 1474317572 JF - Alcohol Health and Research World AU - George, William H AU - Norris, Jeanette Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 133 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol%2C+Disinhibition%2C+Sexual+Arousal%2C+and+Deviant+Sexual+Behavior&rft.au=George%2C+William+H%3BNorris%2C+Jeanette&rft.aulast=George&rft.aufirst=William&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Acculturation and Changes in Drinking Patterns Among Mexican-American Women AN - 1474317559 JF - Alcohol Health and Research World AU - Gilbert, M Jean Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 234 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Acculturation+and+Changes+in+Drinking+Patterns+Among+Mexican-American+Women&rft.au=Gilbert%2C+M+Jean&rft.aulast=Gilbert&rft.aufirst=M&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Effects of Alcohol Abuse on the Health of Adolescents AN - 1474317521 JF - Alcohol Health and Research World AU - Arria, Amelia M AU - Tarter, Ralph E AU - THIEL, DAVID H. VAN Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 52 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Effects+of+Alcohol+Abuse+on+the+Health+of+Adolescents&rft.au=Arria%2C+Amelia+M%3BTarter%2C+Ralph+E%3BTHIEL%2C+DAVID+H.+VAN&rft.aulast=Arria&rft.aufirst=Amelia&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Linking Research with Practice: Common Bonds, Common Progress AN - 1474317515 JF - Alcohol Health and Research World AU - Gordis, Enoch Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 173 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Linking+Research+with+Practice%3A+Common+Bonds%2C+Common+Progress&rft.au=Gordis%2C+Enoch&rft.aulast=Gordis&rft.aufirst=Enoch&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - International Perspectives Initiatives to Curb Alcohol Abuse and Alcoholism in the Former Soviet Union AN - 1474317511 JF - Alcohol Health and Research World AU - Dorman, Nancy D AU - Towle, Leland H Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 303 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=International+Perspectives+Initiatives+to+Curb+Alcohol+Abuse+and+Alcoholism+in+the+Former+Soviet+Union&rft.au=Dorman%2C+Nancy+D%3BTowle%2C+Leland+H&rft.aulast=Dorman&rft.aufirst=Nancy&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474317496 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Fetal Alcohol Effects Among North American Indians AN - 1474317465 JF - Alcohol Health and Research World AU - May, Philip A Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 239 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Fetal+Alcohol+Effects+Among+North+American+Indians&rft.au=May%2C+Philip+A&rft.aulast=May&rft.aufirst=Philip&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Influence of Prenatal Alcohol Exposure on the Process of Neurobehavioral Sexual Differentiation AN - 1474317369 JF - Alcohol Health and Research World AU - McGivern, Robert F AU - Barron, Susan Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 115 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Influence+of+Prenatal+Alcohol+Exposure+on+the+Process+of+Neurobehavioral+Sexual+Differentiation&rft.au=McGivern%2C+Robert+F%3BBarron%2C+Susan&rft.aulast=McGivern&rft.aufirst=Robert&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on the Male Reproductive System AN - 1474317366 JF - Alcohol Health and Research World AU - Wright, Harlan I AU - Gavaler, Judith S AU - Thiel, David Van Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 110 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+the+Male+Reproductive+System&rft.au=Wright%2C+Harlan+I%3BGavaler%2C+Judith+S%3BThiel%2C+David+Van&rft.aulast=Wright&rft.aufirst=Harlan&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - In This Issue - Article Highlights AN - 1474317359 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 171 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=In+This+Issue+-+Article+Highlights&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Nosology of Alcoholism Research AN - 1474317319 JF - Alcohol Health and Research World AU - Beresford, Thomas P Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 260 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Nosology+of+Alcoholism+Research&rft.au=Beresford%2C+Thomas+P&rft.aulast=Beresford&rft.aufirst=Thomas&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Drug Use Screening Inventory: Its Applications in the Evaluation and Treatment of Alcohol and Other Drug Abuse AN - 1474317250 JF - Alcohol Health and Research World AU - Tarter, Ralph E AU - Hegedus, Andrea M Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 65 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Drug+Use+Screening+Inventory%3A+Its+Applications+in+the+Evaluation+and+Treatment+of+Alcohol+and+Other+Drug+Abuse&rft.au=Tarter%2C+Ralph+E%3BHegedus%2C+Andrea+M&rft.aulast=Tarter&rft.aufirst=Ralph&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Special Populations Gay and Alcoholic: Epidemiologic and Clinical Issues AN - 1474317168 JF - Alcohol Health and Research World AU - Paul, Jay P AU - Stall, Ron AU - Bloomfield, Kim A Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 151 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Special+Populations+Gay+and+Alcoholic%3A+Epidemiologic+and+Clinical+Issues&rft.au=Paul%2C+Jay+P%3BStall%2C+Ron%3BBloomfield%2C+Kim+A&rft.aulast=Paul&rft.aufirst=Jay&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Evolution of the DSM Diagnostic Criteria for Alcoholism AN - 1474317167 JF - Alcohol Health and Research World AU - Schuckit, Marc A AU - Nathan, Peter E AU - Helzer, John E AU - Woody, George E AU - Crowley, Tom J Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 278 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Evolution+of+the+DSM+Diagnostic+Criteria+for+Alcoholism&rft.au=Schuckit%2C+Marc+A%3BNathan%2C+Peter+E%3BHelzer%2C+John+E%3BWoody%2C+George+E%3BCrowley%2C+Tom+J&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Just Say Y.E.S.: Matching Adolescents to Appropriate Interventions for Alcohol and Other Drug-Related Problems AN - 1474317156 JF - Alcohol Health and Research World AU - Babor, Thomas F AU - Del Boca, Frances K AU - McLaney, Margaret Anne AU - Jacobi, Barbara AU - Higgins-Biddle, John AU - Hass, William Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 76 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Just+Say+Y.E.S.%3A+Matching+Adolescents+to+Appropriate+Interventions+for+Alcohol+and+Other+Drug-Related+Problems&rft.au=Babor%2C+Thomas+F%3BDel+Boca%2C+Frances+K%3BMcLaney%2C+Margaret+Anne%3BJacobi%2C+Barbara%3BHiggins-Biddle%2C+John%3BHass%2C+William&rft.aulast=Babor&rft.aufirst=Thomas&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 28 Comparative Alcohol-Related Mortality Statistics in the United States by State, 1979-1985 AN - 1474317099 JF - Alcohol Health and Research World AU - Caces, M Fe AU - Stinson, Frederick S AU - Elliott, Steven D AU - Noble, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 161 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+28+Comparative+Alcohol-Related+Mortality+Statistics+in+the+United+States+by+State%2C+1979-1985&rft.au=Caces%2C+M+Fe%3BStinson%2C+Frederick+S%3BElliott%2C+Steven+D%3BNoble%2C+John&rft.aulast=Caces&rft.aufirst=M&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on Female Endocrine Function AN - 1474317056 JF - Alcohol Health and Research World AU - Gavaler, Judith S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 104 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+Female+Endocrine+Function&rft.au=Gavaler%2C+Judith+S&rft.aulast=Gavaler&rft.aufirst=Judith&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Adolescent Alcohol Decisions AN - 1474316999 JF - Alcohol Health and Research World AU - Fischhoff, Baruch AU - Quadrel, Marilyn Jacobs Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 43 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Adolescent+Alcohol+Decisions&rft.au=Fischhoff%2C+Baruch%3BQuadrel%2C+Marilyn+Jacobs&rft.aulast=Fischhoff&rft.aufirst=Baruch&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Promising but Underutilized Treatment Approaches AN - 1474316824 JF - Alcohol Health and Research World AU - McCrady, Barbara S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 215 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Promising+but+Underutilized+Treatment+Approaches&rft.au=McCrady%2C+Barbara+S&rft.aulast=McCrady&rft.aufirst=Barbara&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Enzyme immunoassay for identification of Vibrio vulnificus in seawater, sediment, and oysters AN - 13740010; S199138334 AB - An enzyme immunoassay (EIA) using Vibrio vulnificus-specific monoclonal antibody (MAb) FRBT37 was used to identify Vibrio vulnificus in enrichment broths and agar cultures of oysters, sediment and seawater. The specificity of MAb FRBT37 was determined by EIA by using 72 laboratory stock strains of bacteria (34 species, 15 genera). There were no cross-reactions. The EIA identified correctly 99.7 per cent of 348 biochemically confirmed V. vulnificus isolates. The epitole corresponding to FRBT37 was found in cells lysed by Triton X-100, deionized water and ultrasonication. It was not found in culture supernatants indicating an intracellular location. Transmission electron micrographs of V. vulnificus labelled with FRBT37-biotin-avidin-gold showed that the epitope reacted with fragments of lysed cells but not whole cells. JF - Applied and Environmental Microbiology AU - Tamplin, M L AU - Martin, AL AU - Ruple, AD AU - Cook, D W AU - Kaspar, C W AD - U.S. Food and Drug Administration, Dauphin Island, Ala. Y1 - 1991 PY - 1991 DA - 1991 SP - 1235 EP - 1240 VL - 57 IS - 4 SN - 0099-2240, 0099-2240 KW - Triton X100 KW - Sea water (see also marine -----) KW - Strain (biological) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13740010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Enzyme+immunoassay+for+identification+of+Vibrio+vulnificus+in+seawater%2C+sediment%2C+and+oysters&rft.au=Tamplin%2C+M+L%3BMartin%2C+AL%3BRuple%2C+AD%3BCook%2C+D+W%3BKaspar%2C+C+W&rft.aulast=Tamplin&rft.aufirst=M&rft.date=1991-01-01&rft.volume=57&rft.issue=4&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Identification of uidA gene sequences in beta-D-glucuronidase-negative Escherichia coli AN - 13736360; 199101720 AB - To study the limitations of the 4-methylumbelliferyl-beta-D-glucuronide (MUG) assay for the identification of Escherichia coli in food and water, a synthetic oligonucleotide probe was directed at the uidA gene of E. coli to examine the distribution of the beta-D-glucuronidase (GUD) enzyme genes in E. coli strains. Of the 116 E. coli isolates examined, 112 hybridized with the probe and 4 MUG-positive E. coli isolates failed to hybridize or were weakly reactive with the probe. Southern hybridizations of DNA from selected isolates showed that the probe reacted with a single 900-bp Hinfl fragment. JF - Applied and Environmental Microbiology AU - Feng, P AU - Lum, R AU - Chang, G W AD - Food and Drug Administration, Washington, D.C. Y1 - 1991 PY - 1991 DA - 1991 SP - 320 EP - 323 VL - 57 IS - 1 SN - 0099-2240, 0099-2240 KW - Enzymes (see also individual groups below) KW - Hybridized KW - Strain (biological) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13736360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Identification+of+uidA+gene+sequences+in+beta-D-glucuronidase-negative+Escherichia+coli&rft.au=Feng%2C+P%3BLum%2C+R%3BChang%2C+G+W&rft.aulast=Feng&rft.aufirst=P&rft.date=1991-01-01&rft.volume=57&rft.issue=1&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Human exposure to polychlorinated biphenyls in Greater New Bedford, Massachusetts: a prevalence study AN - 13729727; 199102839 AB - The serum of individuals aged 18 to 64 years in the community of Greater New Bedford, Mass., was examined to assess the prevalence of elevated levels of polychlorinated biphenyls (PCB). Eight-hundred and forty subjects who had resided in the area for at least 5 years were tested. Despite documented contamination by PCB in the New Bedford area and the common practice of fishing in the harbour for food, the prevalence of elevated serum PCB levels was no higher than in typical unexposed U.S. urban populations. Levels were higher than 30 ppb in only 1.3 per cent of the individuals tested, with similar percentages among men and women. Overall, the prevalence of elevated serum PCB in the local population was assessed as low. There are 30 references. JF - Archives of Environmental Contamination and Toxicology AU - Miller, D T AU - Condon, S K AU - Kutzner, S AU - Phillips, D L AU - Krueger, E AU - Timperi, R AU - Burse, V W AU - Cutler, J AU - Gute, D M AD - U.S. Department of Health and Human Services, Atlanta, Ga. Y1 - 1991 PY - 1991 DA - 1991 SP - 410 EP - 416 VL - 20 IS - 3 SN - 0090-4341, 0090-4341 KW - World health organization KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13729727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Human+exposure+to+polychlorinated+biphenyls+in+Greater+New+Bedford%2C+Massachusetts%3A+a+prevalence+study&rft.au=Miller%2C+D+T%3BCondon%2C+S+K%3BKutzner%2C+S%3BPhillips%2C+D+L%3BKrueger%2C+E%3BTimperi%2C+R%3BBurse%2C+V+W%3BCutler%2C+J%3BGute%2C+D+M&rft.aulast=Miller&rft.aufirst=D&rft.date=1991-01-01&rft.volume=20&rft.issue=3&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Identification of a carboxylic acid metabolite from the catabolism of fluoranthene by a Mycobacterium sp AN - 13722625; S199239375 AB - Mineralization of the high-molecular-weight polycyclic aromatic hydrocarbon fluoranthene by Mycobacterium sp. was investigated using flow-through microcosm test systems containing a carbon-14-labelled culture medium. A carboxylic acid metabolite, isolated by thin layer and high pressure liquid chromatography of the acidified ethyl acetate-extractable fraction, reached a maximal concentration of approximately 0.65 per cent after 24 h incubation. The metabolite was identified as 9-fluoranthene-1-carboxylic acid by comparison with authentic compound using UV and fluorescence spectrophotometry, mass spectral and proton and carbon nuclear magnetic resonance spectral analyses. Mycobacterium sp. initially attacked fluoranthene in the fused aromatic ring portion of the molecule and was potentially useful for bioremediation of PAH. There are 31 references. JF - Applied and Environmental Microbiology AU - Kelly, I AU - Freeman, J P AU - Evans, F E AU - Cerniglia, CE AD - Food and Drug Administration, Jefferson, Ark. Y1 - 1991 PY - 1991 DA - 1991 SP - 636 EP - 641 VL - 57 IS - 3 SN - 0099-2240, 0099-2240 KW - Analysis KW - Fluoranthene KW - Media KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13722625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Identification+of+a+carboxylic+acid+metabolite+from+the+catabolism+of+fluoranthene+by+a+Mycobacterium+sp&rft.au=Kelly%2C+I%3BFreeman%2C+J+P%3BEvans%2C+F+E%3BCerniglia%2C+CE&rft.aulast=Kelly&rft.aufirst=I&rft.date=1991-01-01&rft.volume=57&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Nucleotide sequence of the P34 gene from Rickettsia rickettsii. AN - 20209632; 8735026 JF - Nucleic Acids Research AU - Anderson, B E AU - Baumstark, B R AU - Bellini, W J AD - Division of Viral and Rickettsial Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1990/12/11/ PY - 1990 DA - 1990 Dec 11 SP - 7168 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 18 IS - 23 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Nucleotide sequence KW - Rickettsia rickettsii KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20209632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Nucleotide+sequence+of+the+P34+gene+from+Rickettsia+rickettsii.&rft.au=Anderson%2C+B+E%3BBaumstark%2C+B+R%3BBellini%2C+W+J&rft.aulast=Anderson&rft.aufirst=B&rft.date=1990-12-11&rft.volume=18&rft.issue=23&rft.spage=7168&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Rickettsia rickettsii ER - TY - JOUR T1 - Differential changes in lipid metabolism of myeloid and lymphoid cell lines induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). AN - 80198137; 2125010 AB - Treatment of the myeloid cell lines, U-937 or HL-60, with 10 nM of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), for 24 h increased the rate of incorporation of [3H]glycerol into total chloroform extracts. A proportionally greater labeling of the non-polar lipid (NL) fraction compared to the polar, phospholipid (PL), fraction was observed. Chromatographic analysis showed a 6-fold increase in the labeling of triacylglycerols (TAG), a 2-fold increase in diacylglycerols, and no changes in monoacylglycerols. PL labeling showed a 3-fold increase in phosphatidylcholine (PC). The effect of TPA on TAG labeling was selectively observed in myeloid cell lines. No such a change was found in the lymphoid cell line. MOLT-3, which did respond to TPA with increased PC labeling. Incorporation of [3H]arachidonic acid (AA) into TAG by U-937 cells was selectively increased (2.5-fold) after treatment with TPA for 24 h. Treatment of U-937 cells with TPA in serum-free medium resulted in no increased labeling of TAG. These studies suggest that changes in TAG metabolism may be characteristic of myeloid differentiation and depend on the presence of serum factor(s). JF - FEBS letters AU - Ponzoni, M AU - DeBell, K E AU - Hoffman, T AU - Bonvini, E AD - Laboratory of Cell Biology, DBBP, CBER, US-FDA, Bethesda, MD 20892. Y1 - 1990/12/10/ PY - 1990 DA - 1990 Dec 10 SP - 25 EP - 28 VL - 276 IS - 1-2 SN - 0014-5793, 0014-5793 KW - Arachidonic Acids KW - 0 KW - Glycerides KW - Arachidonic Acid KW - 27YG812J1I KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - Glycerides -- metabolism KW - Lymphoma, Large B-Cell, Diffuse KW - Glycerol -- metabolism KW - Kinetics KW - Humans KW - Leukemia, Promyelocytic, Acute KW - Arachidonic Acids -- metabolism KW - Cell Line KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80198137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Differential+changes+in+lipid+metabolism+of+myeloid+and+lymphoid+cell+lines+induced+by+treatment+with+12-O-tetradecanoylphorbol-13-acetate+%28TPA%29.&rft.au=Ponzoni%2C+M%3BDeBell%2C+K+E%3BHoffman%2C+T%3BBonvini%2C+E&rft.aulast=Ponzoni&rft.aufirst=M&rft.date=1990-12-10&rft.volume=276&rft.issue=1-2&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-14 N1 - Date created - 1991-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Airborne endotoxin concentrations in various work areas within two cotton textile mills in the People's Republic of China. AN - 80343067; 2096849 AB - As part of a multidisciplinary longitudinal approach to assess the roles of airborne cotton dust and endotoxins in affecting the respiratory health of cotton textile workers, this study was designed to quantify the endotoxin contamination of airborne vertically elutriated and total dusts. Yarn preparation areas (opening through fine spinning) were studied at two cotton textile mills which had been studied 5 years previously in Shanghai. People's Republic of China, Filter, with vertically elutriated (VE) or total dusts were mailed to the United States and endotoxin analyses were performed for each filter in duplicate with the quantitative chromogenic modification of the Limulus amebocyte lysate assay. Dusts from all areas of the textile mills contained endotoxins. Endotoxin burdens in VE dusts from the carding area were similar in both milk while the endotoxin contamination of total dust from carding in Mill 1 was over threefold greater than that of total dust from carding in Mill 2. All other areas differed between milk in both VE and total dust endotoxin burdens. Mean endotoxin levels in VE dusts from all areas of both mills were well above the reported threshold of 90 EU/m3 for acute pulmonary function effects in humans. Comparison of selected areas of both mills from the present study with the same work areas from the previous study showed that, in general, the airborne endotoxin burden was higher than levels found 5 years ago in these two mills. The data suggest that even with reduced or unchanged gravimetric dust levels in these two cotton textile mills, airborne endotoxin levels were higher and provided an increased potential for adverse respiratory response in exposed workers. JF - Biomedical and environmental sciences : BES AU - Olenchock, S A AU - Christiani, D C AU - Mull, J C AU - Ye, T T AU - Lu, P L AD - Immunology Section, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 443 EP - 451 VL - 3 IS - 4 SN - 0895-3988, 0895-3988 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Endotoxins KW - Index Medicus KW - Humans KW - Textile Industry KW - China KW - Occupational Exposure KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- toxicity KW - Endotoxins -- analysis KW - Endotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80343067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Airborne+endotoxin+concentrations+in+various+work+areas+within+two+cotton+textile+mills+in+the+People%27s+Republic+of+China.&rft.au=Olenchock%2C+S+A%3BChristiani%2C+D+C%3BMull%2C+J+C%3BYe%2C+T+T%3BLu%2C+P+L&rft.aulast=Olenchock&rft.aufirst=S&rft.date=1990-12-01&rft.volume=3&rft.issue=4&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-19 N1 - Date created - 1991-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral contraceptive oestrogen and progestin potencies and the incidence of deep venous thromboembolism. AN - 80311372; 2084024 AB - To assess possible differences in the incidence of venous thrombosis and pulmonary embolism associated with oral contraceptives of varying hormonal potencies, the authors conducted a retrospective cohort study in the 15-44 year old Michigan Medicaid population. Cohorts were defined by the progestin- and oestrogen-potencies of oral contraceptives in use at the time of follow-up as classified by an oral contraceptive potency scheme. Using the low-oestrogen-/low-progestin-potency formulations for reference (rate ratio = 1), adjusted rate ratios of 0.8 (95% CI: 0.5 to 1.3, P = 0.41) and 0.6 (95% CI 0.4 to 1.2, P = 0.13) were observed for intermediate-progestin-potency and high-progestin-potency formulations, respectively. Adjusted rate ratios of 1.4 (95% CI: 0.8 to 2.3, P = 0.21) and 2.6 (95% CI: 1.2 to 5.5, P = 0.01) were observed for intermediate- and high-oestrogen-potency formulations. These data suggest a dose-response relationship between oral contraceptive oestrogen potency and venous thromboembolism, whereas no such evidence for a dose-response relationship between oral contraceptive progestin potency and venous thrombo-embolism was found. JF - International journal of epidemiology AU - Gerstman, B B AU - Piper, J M AU - Freiman, J P AU - Tomita, D K AU - Kennedy, D L AU - Ferguson, W J AU - Bennett, R C AD - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 931 EP - 936 VL - 19 IS - 4 SN - 0300-5771, 0300-5771 KW - Contraceptives, Oral, Hormonal KW - 0 KW - Estradiol Congeners KW - Progestins KW - Index Medicus KW - Population KW - United States KW - Measurement KW - Drug Interactions KW - Age Factors KW - Research Methodology KW - Physiology KW - Retrospective Studies KW - Medical Assistance, Title 19 KW - Oral Contraceptives KW - Aged KW - Contraceptive Methods KW - Treatment KW - Hormones KW - Developed Countries KW - Thromboembolism KW - Progesterone--analysis KW - Population Characteristics KW - Financial Activities KW - Public Assistance KW - Adult KW - Demographic Factors KW - Diseases KW - Family Planning KW - Drugs KW - North America KW - Americas KW - Estrogens--analysis KW - Vascular Diseases KW - Endocrine System KW - Studies KW - Cohort Analysis KW - Economic Factors KW - Financing, Government KW - Northern America KW - Progestational Hormones KW - Contraception KW - Embolism KW - Risk Factors KW - Incidence KW - Michigan KW - Biology KW - Humans KW - Cohort Studies KW - Adolescent KW - Michigan -- epidemiology KW - Female KW - Estradiol Congeners -- adverse effects KW - Thrombophlebitis -- epidemiology KW - Thrombophlebitis -- chemically induced KW - Progestins -- adverse effects KW - Progestins -- administration & dosage KW - Estradiol Congeners -- administration & dosage KW - Contraceptives, Oral, Hormonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80311372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Oral+contraceptive+oestrogen+and+progestin+potencies+and+the+incidence+of+deep+venous+thromboembolism.&rft.au=Gerstman%2C+B+B%3BPiper%2C+J+M%3BFreiman%2C+J+P%3BTomita%2C+D+K%3BKennedy%2C+D+L%3BFerguson%2C+W+J%3BBennett%2C+R+C&rft.aulast=Gerstman&rft.aufirst=B&rft.date=1990-12-01&rft.volume=19&rft.issue=4&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-15 N1 - Date created - 1991-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Epidemiol. 1992 Apr;21(2):420-1 [1428500] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Study of the teratogenic potential of FD & C Yellow No. 5 when given by gavage to rats. AN - 80224832; 2276704 AB - FD & C Yellow No. 5 (tartrazine) was given to Osborne-Mendel rats by gavage at dose levels of 0, 60, 100, 200, 400, 600 or 1000 mg/kg body weight/day on days 0-19 of gestation. No maternal or developmental toxicity was observed when the rats were killed on day 20. The mean daily food consumption for the entire period of gestation was significantly greater in the females given 1000 mg/kg body weight/day than in the controls, but maternal body-weight gain was not affected. No dose-related effects were observed in implantations, foetal viability or external foetal development. Foetal skeletal and visceral development was similar among foetuses from all groups. At the doses given, FD & C Yellow No. 5 was neither toxic nor teratogenic. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Collins, T F AU - Black, T N AU - Brown, L H AU - Bulhack, P AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 821 EP - 827 VL - 28 IS - 12 SN - 0278-6915, 0278-6915 KW - Tartrazine KW - I753WB2F1M KW - Index Medicus KW - Rats KW - Eating -- drug effects KW - Administration, Oral KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Male KW - Female KW - Abnormalities, Drug-Induced KW - Pregnancy -- drug effects KW - Tartrazine -- administration & dosage KW - Tartrazine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80224832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Study+of+the+teratogenic+potential+of+FD+%26amp%3B+C+Yellow+No.+5+when+given+by+gavage+to+rats.&rft.au=Collins%2C+T+F%3BBlack%2C+T+N%3BBrown%2C+L+H%3BBulhack%2C+P&rft.aulast=Collins&rft.aufirst=T&rft.date=1990-12-01&rft.volume=28&rft.issue=12&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-01 N1 - Date created - 1991-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of mononitrodihydrobenzo[a]pyrenes. AN - 80199749; 2266979 JF - Mutation research AU - Fu, P P AU - Jung, H AU - Von Tungeln, L S AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 277 EP - 285 VL - 245 IS - 4 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Nitro Compounds KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Molecular Structure KW - Mutagenicity Tests KW - Salmonella typhimurium -- growth & development KW - Salmonella typhimurium -- genetics KW - Nitro Compounds -- toxicity KW - Benzo(a)pyrene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80199749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutagenicity+of+mononitrodihydrobenzo%5Ba%5Dpyrenes.&rft.au=Fu%2C+P+P%3BJung%2C+H%3BVon+Tungeln%2C+L+S%3BHeflich%2C+R+H&rft.aulast=Fu&rft.aufirst=P&rft.date=1990-12-01&rft.volume=245&rft.issue=4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-14 N1 - Date created - 1991-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of liver, kidney, and erythrocyte delta-aminolevulinic acid dehydratase (porphobilinogen synthase) by gallium in the rat. AN - 80164386; 2253599 AB - Selective inhibition of enzymes in the heme biosynthesis pathway with concomitant urinary excretion of heme precursors serve as potentially important biological markers of chemical exposure and cell injury. Intratracheal administration of gallium arsenide particulate suspensions has been shown to result in inhibition of delta-aminolevulinic acid dehydratase (ALAD) in several tissues and increased excretion of the heme precursor aminolevulinic acid (ALA). This study was undertaken to evaluate in vivo the role of gallium alone in ALAD inhibition and increased urinary excretion of ALA. Male CD rats received a single ip injection of Ga2(SO4)3 at doses of 12.5, 25, 50, 100, and 200 mg Ga/kg. A dose-dependent inhibition of ALAD was observed 24 hr later in liver, kidney, and erythrocytes. After injection of 25 mg Ga/kg, maximal inhibition (42 to 49% of control) of ALAD occurred between 6 and 24 hr in liver and kidney with full recovery of activity at 96 hr. In erythrocytes, maximal inhibition (48% of control) occurred between 24 and 48 hr with recovery of activity at 96 hr. Mild to moderate renal proximal tubular necrosis in the pars recta was observed 24 hr after administration of 100 and 200 mg/kg, but no histopathologic changes were evident at lower doses. No consistent changes in urinary excretion of ALA were observed. Lineweaver-Burk analyses of renal and hepatic ALAD activities in the absence and presence of gallium indicated that the inhibition of ALAD by this element is noncompetitive (same Km, decreased Vmax). Gallium was shown to possess an inhibition constant (Ki) of approximately 3 microns for ALAD, similar to the Ki obtained for lead in other studies. Incubation of ALAD in vitro with gallium and lead, an active thiol group inhibitor, resulted in a greater inhibition of the enzyme. Further in vitro studies demonstrated the attenuation of gallium inhibition of hepatic and renal ALAD by zinc, suggesting that the mechanism of gallium action may involve competition for or displacement of zinc from the sulfhydryl group of the enzyme active site. Since ALAD inhibition occurred at doses at which no histopathologic changes were evident, the determination of ALAD activity in various tissues, including blood, may be of potential value as a biomarker of exposure/toxicity to metals such as gallium. The effect of chemical form and route of exposure of gallium and effects of other Group III metals on inhibition of ALAD and excretion of ALA is discussed.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Environmental research AU - Goering, P L AU - Rehm, S AD - Division of Life Science, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 135 EP - 151 VL - 53 IS - 2 SN - 0013-9351, 0013-9351 KW - Lead KW - 2P299V784P KW - Gallium KW - CH46OC8YV4 KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Zinc -- pharmacology KW - Drug Interactions KW - Kinetics KW - Lead -- pharmacology KW - Male KW - Porphobilinogen Synthase -- antagonists & inhibitors KW - Erythrocytes -- drug effects KW - Liver -- enzymology KW - Erythrocytes -- enzymology KW - Gallium -- pharmacology KW - Liver -- drug effects KW - Kidney -- enzymology KW - Kidney -- drug effects KW - Porphobilinogen Synthase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80164386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Inhibition+of+liver%2C+kidney%2C+and+erythrocyte+delta-aminolevulinic+acid+dehydratase+%28porphobilinogen+synthase%29+by+gallium+in+the+rat.&rft.au=Goering%2C+P+L%3BRehm%2C+S&rft.aulast=Goering&rft.aufirst=P&rft.date=1990-12-01&rft.volume=53&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-22 N1 - Date created - 1991-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - US food legislation. AN - 80162134; 1979377 JF - Lancet (London, England) AU - Thompson, P AU - Salsbury, P A AU - Adams, C AU - Archer, D L AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. PY - 1990 SP - 1557 EP - 1559 VL - 336 IS - 8730 SN - 0140-6736, 0140-6736 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Food Contamination -- prevention & control KW - Food Microbiology -- standards KW - Food Contamination -- legislation & jurisprudence KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80162134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=US+food+legislation.&rft.au=Thompson%2C+P%3BSalsbury%2C+P+A%3BAdams%2C+C%3BArcher%2C+D+L&rft.aulast=Thompson&rft.aufirst=P&rft.date=1990-12-01&rft.volume=336&rft.issue=8730&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=01406736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-24 N1 - Date created - 1991-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seafood safety. AN - 80135564; 2244553 JF - American family physician AU - Nightingale, S L AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1657 EP - 1658 VL - 42 IS - 6 SN - 0002-838X, 0002-838X KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Fishes -- microbiology KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Food Microbiology KW - Fish Products -- standards KW - Shellfish -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80135564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Seafood+safety.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1990-12-01&rft.volume=42&rft.issue=6&rft.spage=1657&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-03 N1 - Date created - 1991-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of tetanus toxin on oxytocin and vasopressin release from nerve endings of the neurohypophysis. AN - 80087932; 2172468 AB - The effect of tetanus toxin on neuropeptide hormone release from isolated nerve endings of the neural lobe of rat pituitaries (neurosecretosomes) was measured in a perfusion system. Tetanus toxin inhibited depolarization-evoked release of oxytocin and vasopressin in a time- and dose-dependent manner. At 1 microgram/ml, tetanus toxin blocked stimulated release by 85%. Tetanus toxin that was preincubated with a neutralizing monoclonal antibody or heated to 100 degrees C had no effect on hormone release. The ionophores A23187 and ionomycin were potent stimulators of hormone release in control nerve endings, but were not able to overcome the effect of tetanus toxin in intoxicated nerve endings. 8-Bromo-cyclic GMP, which has been reported to reverse the action of tetanus toxin in PC12 cells, had no effect on the action of tetanus toxin in neurosecretosomes. Neurosecretosomes are the first system in which tetanus toxin has been shown to block release from peptidergic nerve terminals. They appear to be a valuable in vitro system for studying the biochemical mechanism of tetanus toxin action. JF - Journal of neurochemistry AU - Halpern, J L AU - Habig, W H AU - Trenchard, H AU - Russell, J T AD - Division of Bacterial Products, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 2072 EP - 2078 VL - 55 IS - 6 SN - 0022-3042, 0022-3042 KW - Tetanus Toxin KW - 0 KW - Vasopressins KW - 11000-17-2 KW - 8-bromocyclic GMP KW - 31356-94-2 KW - Calcimycin KW - 37H9VM9WZL KW - Oxytocin KW - 50-56-6 KW - Ionomycin KW - 56092-81-0 KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Osmolar Concentration KW - Animals KW - Cyclic GMP -- pharmacology KW - Ionomycin -- pharmacology KW - Calcimycin -- pharmacology KW - Time Factors KW - Male KW - Cyclic GMP -- analogs & derivatives KW - Nerve Endings -- metabolism KW - Vasopressins -- metabolism KW - Oxytocin -- antagonists & inhibitors KW - Vasopressins -- antagonists & inhibitors KW - Oxytocin -- metabolism KW - Pituitary Gland, Posterior -- metabolism KW - Tetanus Toxin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80087932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Effect+of+tetanus+toxin+on+oxytocin+and+vasopressin+release+from+nerve+endings+of+the+neurohypophysis.&rft.au=Halpern%2C+J+L%3BHabig%2C+W+H%3BTrenchard%2C+H%3BRussell%2C+J+T&rft.aulast=Halpern&rft.aufirst=J&rft.date=1990-12-01&rft.volume=55&rft.issue=6&rft.spage=2072&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-20 N1 - Date created - 1990-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Application of multidimensional gas chromatography-mass spectrometry to the determination of glycol ethers in air. AN - 80312432; 2081755 AB - The applicability of multidimensional gas chromatography-mass spectrometry to the analysis of five glycol ethers in air was demonstrated. Air samples were collected on charcoal tubes and desorbed with 5% methanol in methylene chloride as is described in method 1403 of the National Institute for Occupational Safety and Health Manual of Analytical Methods. The glycol ethers were determined by multidimensional gas chromatography-mass spectrometry. The limit of detection was 5 to 7 micrograms/sample for each compound. JF - Journal of chromatography AU - Kennedy, E R AU - O'Connor, P F AU - Grote, A A AD - Inorganic Methods Development Section, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/11/28/ PY - 1990 DA - 1990 Nov 28 SP - 303 EP - 313 VL - 522 KW - Air Pollutants, Occupational KW - 0 KW - Ethylene Glycols KW - Methyl Ethers KW - Propylene Glycols KW - Charcoal KW - 16291-96-6 KW - dipropylene glycol monomethyl ether KW - 34590-94-8 KW - n-butoxy-2-propanol KW - 5131-66-8 KW - butyl carbitol KW - 9TB90IYC0E KW - n-butoxyethanol KW - I0P9XEZ9WV KW - Index Medicus KW - Propylene Glycols -- analysis KW - Methyl Ethers -- analysis KW - Gas Chromatography-Mass Spectrometry -- methods KW - Air Pollutants, Occupational -- analysis KW - Ethylene Glycols -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80312432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography&rft.atitle=Application+of+multidimensional+gas+chromatography-mass+spectrometry+to+the+determination+of+glycol+ethers+in+air.&rft.au=Kennedy%2C+E+R%3BO%27Connor%2C+P+F%3BGrote%2C+A+A&rft.aulast=Kennedy&rft.aufirst=E&rft.date=1990-11-28&rft.volume=522&rft.issue=&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-07 N1 - Date created - 1991-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - NIOSH method 7402--asbestos fibers (Revision #1)--low-temperature ashing of filter samples. AN - 80313359; 2085160 JF - American Industrial Hygiene Association journal AU - Baron, P A AU - Platek, S F AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - A730 EP - A731 VL - 51 IS - 11 SN - 0002-8894, 0002-8894 KW - Air Pollutants KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Electron Probe Microanalysis KW - Particle Size KW - Microscopy, Electron KW - Cold Temperature KW - Air Pollutants -- analysis KW - Microscopy, Electron, Scanning KW - Asbestos -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80313359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=NIOSH+method+7402--asbestos+fibers+%28Revision+%231%29--low-temperature+ashing+of+filter+samples.&rft.au=Baron%2C+P+A%3BPlatek%2C+S+F&rft.aulast=Baron&rft.aufirst=P&rft.date=1990-11-01&rft.volume=51&rft.issue=11&rft.spage=A730&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-10 N1 - Date created - 1991-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Migration into food of polyethylene terephthalate (PET) cyclic oligomers from PET microwave susceptor packaging. AN - 80293124; 2150379 AB - A quantitative method has been developed to measure the migration of polyethylene terephthalate (PET) cyclic oligomers from aluminized PET susceptor film-type food packaging into several food types. Microwaveable French fries, popcorn, fish sticks, waffles and pizza sold in susceptor-type packaging were purchased in local markets, cooked according to package instructions and analysed for PET oligomers. Appropriate food blanks were cooked in glass containers. Quantities of PET oligomers found in the foods ranged from less than 0.012 micrograms/g to approximately 7 micrograms/g. JF - Food additives and contaminants AU - Begley, T H AU - Dennison, J L AU - Hollifield, H C AD - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204. PY - 1990 SP - 797 EP - 803 VL - 7 IS - 6 SN - 0265-203X, 0265-203X KW - Polyethylene Terephthalates KW - 0 KW - Index Medicus KW - Cooking KW - Chromatography, High Pressure Liquid KW - Hot Temperature KW - Microwaves KW - Food Contamination -- analysis KW - Cooking and Eating Utensils KW - Polyethylene Terephthalates -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80293124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Migration+into+food+of+polyethylene+terephthalate+%28PET%29+cyclic+oligomers+from+PET+microwave+susceptor+packaging.&rft.au=Begley%2C+T+H%3BDennison%2C+J+L%3BHollifield%2C+H+C&rft.aulast=Begley&rft.aufirst=T&rft.date=1990-11-01&rft.volume=7&rft.issue=6&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-29 N1 - Date created - 1991-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A displacement pump procedure to load extracts for automated gel permeation chromatography. AN - 80265248; 2289932 AB - Automated gel permeation chromatography (GPC) effectively separates lipids from pesticides in sample extracts that contain fat. Using a large syringe to load sample extracts manually onto GPC models having 5 mL holding loops is awkward, slow, and potentially hazardous. Loading with a small-volume displacement pump, however, is convenient and fast (ca 1 loop every 20 s). And more importantly, the analyst is not exposed to toxic organic vapors because the loading pump and its connecting lines do not leak in the way that a syringe does. JF - Journal - Association of Official Analytical Chemists AU - Daft, J AU - Hopper, M AU - Hensley, D AU - Sisk, R AD - Food and Drug Administration, Department of Health and Human Services, Kansas City District Office, MO 64106. PY - 1990 SP - 992 EP - 994 VL - 73 IS - 6 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - Food Contamination -- analysis KW - Pesticide Residues -- analysis KW - Autoanalysis -- instrumentation KW - Specimen Handling -- instrumentation KW - Chromatography, Gel -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80265248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=A+displacement+pump+procedure+to+load+extracts+for+automated+gel+permeation+chromatography.&rft.au=Daft%2C+J%3BHopper%2C+M%3BHensley%2C+D%3BSisk%2C+R&rft.aulast=Daft&rft.aufirst=J&rft.date=1990-11-01&rft.volume=73&rft.issue=6&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-03 N1 - Date created - 1991-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of gentian violet, its demethylated metabolites, and leucogentian violet in chicken tissue by liquid chromatography with electrochemical detection. AN - 80261760; 2289926 AB - A method is presented for determination of residues of gentian violet (GV), its demethylated metabolites (pentamethyl and tetramethyl), and leucogentian violet (LGV) in chicken tissue. The analytes are extracted from tissue with acetonitrile/buffer and partitioned into methylene chloride. Polar lipids are removed on an alumina column followed by partitioning into methylene chloride from a citrate buffer. The compounds of interest are isolated on a disposable carboxylic acid cation exchange column and then eluted with 0.02% HCl in methanol. GV, its metabolites, and LGV are determined by liquid chromatography using isocratic elution with a buffered mobile phase from a cyano column and amperometric electrochemical detection at +1.000 V. Average recoveries of GV and LGV from commercially purchased chicken liver fortified with 20 ppb of each compound were 92% [standard deviation (SD) = 7, coefficient of variation (CV) = 7.6%] and 86% (SD = 7, CV = 8.1%), respectively. Average recoveries of GV, LGV, the pentamethyl metabolite, and 1 of the tetramethyl metabolites from control chicken liver (provided by the Center for Veterinary Medicine) fortified with 20 ppb of each compound were 80% (SD = 7, CV = 8.8%), 76% (SD = 3, CV = 3.9%), 83% (SD = 6, CV = 7.2%), and 76% (SD = 8, CV = 10.5%), respectively. Mean results from 10 analyses of residue-incurred chicken liver were 31 ppb GV (SD = 3, CV = 9.7%), 34 ppb pentamethyl metabolite (SD = 3, CV = 8.8%), and 40 ppb tetramethyl metabolite(s) (SD = 2, CV = 5.0%), for an average value of 105 ppb total residues (SD = 6, CV = 5.7%); no LGV was found. Data are also presented to show applicability of the method to muscle tissue. JF - Journal - Association of Official Analytical Chemists AU - Roybal, J E AU - Munns, R K AU - Hurlbut, J A AU - Shimoda, W AD - Food and Drug Administration, Denver Federal Center, CO 80225-0087. PY - 1990 SP - 940 EP - 946 VL - 73 IS - 6 SN - 0004-5756, 0004-5756 KW - leucogentian violet KW - 603-48-5 KW - Gentian Violet KW - J4Z741D6O5 KW - Aluminum Oxide KW - LMI26O6933 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Muscles -- chemistry KW - Chromatography, Liquid -- methods KW - Reference Standards KW - Electrochemistry KW - Methylation KW - Liver -- chemistry KW - Drug Residues -- analysis KW - Food Contamination -- analysis KW - Meat -- analysis KW - Gentian Violet -- analysis KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80261760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Determination+of+gentian+violet%2C+its+demethylated+metabolites%2C+and+leucogentian+violet+in+chicken+tissue+by+liquid+chromatography+with+electrochemical+detection.&rft.au=Roybal%2C+J+E%3BMunns%2C+R+K%3BHurlbut%2C+J+A%3BShimoda%2C+W&rft.aulast=Roybal&rft.aufirst=J&rft.date=1990-11-01&rft.volume=73&rft.issue=6&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756