TY - JOUR T1 - Reevaluation of silicosis and lung cancer in North Carolina dusty trades workers. AN - 85255801; pmid-1415283 AB - We previously reported on the lung cancer mortality through 1983 of 760 males who were diagnosed with silicosis during 1930-1983 by the State of North Carolina's medical examination program for dusty trades workers. The lung cancer SMR (95% confidence interval) was 2.6 (1.8-3.6) among 655 white members of this group. In this paper, we report the results of a reanalysis of mortality among a subgroup for whom chest radiographs were currently available for rereading. Technically acceptable radiographs were available for 306 white males and were independently reclassified for pneumoconiosis by 3 "B" readers using the 1980 ILO Classification. Lung cancer SMRs were 1.7 (0.8-3.1) for the entire group of 306 white males, 2.5 (1.1-4.9) for 143 subjects reclassified as simple silicosis, and 1.0 (0.1-3.5) for 96 subjects whose radiographs were reclassified as ILO category 0. There were no lung cancer deaths among 67 subjects whose radiographs were reclassified as progressive massive fibrosis. Corresponding lung cancer SMRs for subjects who had never been employed in a job with exposure to known occupational carcinogens were 1.2 (0.2-4.4) for those reclassified as category 0, and 2.4 (1.0-5.0) for those reclassified as having simple silicosis. The age-adjusted lung cancer rate ratio among subjects with simple silicosis compared to those with category 0 was 1.5 (0.4-5.8). Our findings from this reanalysis, which effectively controls for misclassification of silicosis due to errors in radiograph interpretation by North Carolina program readers, offer additional evidence consistent with the hypothesis of an association between silicosis and lung cancer in this study group. JF - American Journal of Industrial Medicine AU - Amandus, H E AU - Castellan, R M AU - Shy, C AU - Heineman, E F AU - Blair, A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. PY - 1992 SP - 147 EP - 153 VL - 22 IS - 2 SN - 0271-3586, 0271-3586 KW - Smoking KW - Evaluation Studies KW - Lung Neoplasms KW - Human KW - Silicosis KW - Adult KW - North Carolina KW - Aged KW - Middle Age KW - Follow-Up Studies KW - Occupational Diseases KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85255801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Reevaluation+of+silicosis+and+lung+cancer+in+North+Carolina+dusty+trades+workers.&rft.au=Amandus%2C+H+E%3BCastellan%2C+R+M%3BShy%2C+C%3BHeineman%2C+E+F%3BBlair%2C+A&rft.aulast=Amandus&rft.aufirst=H&rft.date=1992-01-01&rft.volume=22&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers. AN - 73436415; 1463030 AB - We investigated the cardiotoxic effects of 1,1,2-Trichloro-1,2,2- Trifluoroethane (fluorocarbon 113 or FC113) exposures among healthy workers cleaning rocket and ground support equipment for the National Aeronautic and Space Administration (NASA) programs. Exposure and ambulatory electrocardiographic (ECG) monitoring data were evaluated on 16 workers, each of whom was examined on exposed and nonexposed workdays. We examined whether there was a greater rate of dysrhythmias on an exposed workday relative to a nonexposed workday. Overall, we found no within subject differences in the rate of ventricular and supraventricular premature beats (number per 1,000 heart beats), fluctuations in the length of the P-R interval, or heart rate. We found that levels of FC113 exposures below the Occupational Safety and Health Administration (OSHA) 8-hour time-weighted-average (TWA) standard of 1,000 ppm did not induce cardiac dysrhythmias or subtle changes in cardiac activity. However, because fluorocarbons may sensitize the heart to epinephrine, this study's negative findings based on sedentary and fairly healthy workers may not be generalizable to other populations of workers who are not as healthy or engaged in more physically demanding work. JF - American journal of industrial medicine AU - Egeland, G M AU - Bloom, T F AU - Schnorr, T M AU - Hornung, R W AU - Suruda, A J AU - Wille, K K AD - National Institute for Occupational Safety and Health, Industrywide Studies Branch, Cincinnati, OH 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 851 EP - 857 VL - 22 IS - 6 SN - 0271-3586, 0271-3586 KW - Chlorofluorocarbons, Ethane KW - 0 KW - Chlorofluorocarbons, Methane KW - 1,1,1-trichloro-2,2,2-trifluoroethane KW - 07H0R79HO0 KW - Index Medicus KW - Space life sciences KW - Electrocardiography, Ambulatory KW - Humans KW - Adult KW - Male KW - Female KW - Occupational Exposure KW - Arrhythmias, Cardiac -- diagnosis KW - Arrhythmias, Cardiac -- chemically induced KW - Space Flight KW - Chlorofluorocarbons, Methane -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73436415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Fluorocarbon+113+exposure+and+cardiac+dysrhythmias+among+aerospace+workers.&rft.au=Egeland%2C+G+M%3BBloom%2C+T+F%3BSchnorr%2C+T+M%3BHornung%2C+R+W%3BSuruda%2C+A+J%3BWille%2C+K+K&rft.aulast=Egeland&rft.aufirst=G&rft.date=1992-01-01&rft.volume=22&rft.issue=6&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-11 N1 - Date created - 1993-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outbreak of hypersensitivity pneumonitis among mushroom farm workers. AN - 73399712; 1463031 AB - Between April 1982 and August 1985, seven cases of mushroom worker's lung (MWL), a form of hypersensitivity pneumonitis, were diagnosed among workers at one mushroom farm in Florida. The cases suffered from episodic shortness of breath, cough, fever and chills, myalgia, malaise, and difficulty breathing. Pulmonary function testing revealed restrictive ventilatory impairment and reduced diffusing capacity; chest radiographs exhibited diffuse interstitial pulmonary infiltrates. The seven cases occurred among workers from different farm operations, suggesting that workers throughout the farm were exposed to the disease causing agent(s). Six of the affected workers left employment at the farm in order to remain free of symptoms. The other affected worker was able to continue working at the farm, but only by remaining in a maintenance shop which was physically separated from the rest of the farm facilities. An industrial hygiene survey demonstrated that farm workers from every work area were exposed to organic dust constituents suspected of causing MWL, but no specific antigens were identified as the cause of the cases. Of the remaining workers who participated in a cross-sectional respiratory morbidity survey at the farm, approximately 20% of the more heavily exposed workers reported occasionally experiencing symptoms consistent with MWL. Approximately 10% of the workers had below normal spirometry test results, but interpretation was hampered by the diverse racial makeup of the population and lack of an adequate comparison group. No abnormalities consistent with either acute or chronic MWL were seen on the chest radiographs. Serologic tests demonstrated that almost all workers had been exposed to antigens capable of causing MWL, but the results were not associated with health status. At the time of the cross-sectional survey, no workers were found to be suffering acute respiratory problems consistent with MWL. JF - American journal of industrial medicine AU - Sanderson, W AU - Kullman, G AU - Sastre, J AU - Olenchock, S AU - O'Campo, A AU - Musgrave, K AU - Green, F AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1992 PY - 1992 DA - 1992 SP - 859 EP - 872 VL - 22 IS - 6 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Respiratory Function Tests KW - Cross-Sectional Studies KW - Lung -- diagnostic imaging KW - Serologic Tests KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Radiography KW - Male KW - Female KW - Florida -- epidemiology KW - Basidiomycota KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- diagnosis KW - Disease Outbreaks KW - Alveolitis, Extrinsic Allergic -- epidemiology KW - Alveolitis, Extrinsic Allergic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73399712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Outbreak+of+hypersensitivity+pneumonitis+among+mushroom+farm+workers.&rft.au=Sanderson%2C+W%3BKullman%2C+G%3BSastre%2C+J%3BOlenchock%2C+S%3BO%27Campo%2C+A%3BMusgrave%2C+K%3BGreen%2C+F&rft.aulast=Sanderson&rft.aufirst=W&rft.date=1992-01-01&rft.volume=22&rft.issue=6&rft.spage=859&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-11 N1 - Date created - 1993-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A mortality study of workers at seven beryllium processing plants. AN - 73385040; 1463033 AB - The International Agency for Research on Cancer (IARC) has found that the evidence for the carcinogenicity of beryllium is sufficient based on animal data but "limited" based on human data. This analysis reports on a retrospective cohort mortality study among 9,225 male workers employed at seven beryllium processing facilities for at least 2 days between January 1, 1940, and December 31, 1969. Vital status was ascertained through December 31, 1988. The standardized mortality ratio (SMR) for lung cancer in the total cohort was 1.26 (95% confidence interval [CI] = 1.12-1.42); significant SMRs for lung cancer were observed for two of the oldest plants located in Lorain, Ohio (SMR = 1.69; 95% CI = 1.28-2.19) and Reading, Pennsylvania (SMR = 1.24; 95% CI = 1.03-1.48). For the overall cohort, significantly elevated SMRs were found for "all deaths" (SMR = 1.05; 95% CI = 1.01-1.08), "ischemic heart disease" (SMR = 1.08; 95% CI = 1.01-1.14), "pneumoconiosis and other respiratory diseases" (SMR = 1.48; 95% CI = 1.21-1.80), and "chronic and unspecified nephritis, renal failure, and other renal sclerosis" (SMR = 1.49; 95% CI = 1.00-2.12). Lung cancer SMRs did not increase with longer duration of employment, but did increase with longer latency (time since first exposure). Lung cancer was particularly elevated (SMR = 3.33; 95% CI = 1.66-5.95) among workers at the Lorain plant with a history of (primarily) acute beryllium disease, which is associated with very high beryllium exposure. The lung cancer excess was not restricted to plants operating in the 1940s, when beryllium exposures were known to be extraordinarily high. Elevated lung cancer SMRs were also observed for four of the five plants operating in the 1950s for workers hired during that decade. Neither smoking nor geographic location fully explains the increased lung cancer risk. Occupational exposure to beryllium compounds is the most plausible explanation for the increased risk of lung cancer observed in this study. Continued mortality follow-up of this cohort will provide a more definitive assessment of lung cancer risk at the newer plants and among cohort members hired in the 1950s or later at the older plants. Further clarification of the potential for specific beryllium compounds to induce lung cancer in humans, and the possible contribution of other exposures in specific processes at these plants, would require a nested case-control study. We are currently assessing whether available industrial hygiene data would support such an analysis. JF - American journal of industrial medicine AU - Ward, E AU - Okun, A AU - Ruder, A AU - Fingerhut, M AU - Steenland, K AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 885 EP - 904 VL - 22 IS - 6 SN - 0271-3586, 0271-3586 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Ohio -- epidemiology KW - Berylliosis -- mortality KW - Pennsylvania -- epidemiology KW - Male KW - Cause of Death KW - Survival Analysis KW - Cardiovascular Diseases -- mortality KW - Respiration Disorders -- mortality KW - Beryllium -- adverse effects KW - Lung Neoplasms -- mortality KW - Cardiovascular Diseases -- chemically induced KW - Lung Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced KW - Respiration Disorders -- chemically induced KW - Chemical Industry KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73385040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=A+mortality+study+of+workers+at+seven+beryllium+processing+plants.&rft.au=Ward%2C+E%3BOkun%2C+A%3BRuder%2C+A%3BFingerhut%2C+M%3BSteenland%2C+K&rft.aulast=Ward&rft.aufirst=E&rft.date=1992-01-01&rft.volume=22&rft.issue=6&rft.spage=885&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-11 N1 - Date created - 1993-01-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 2001 Sep;40(3):284-8 [11598976] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of chemical toxicity by modification of caloric intake. AN - 73334884; 1442303 AB - Caloric restriction increases maximum achievable lifespan and offsets the time to development of degenerative disease. Part of these desirable effects may result from positive modulation of toxic events. We have shown that when rodents are placed on a diet that is reduced in total calories by 40%, several beneficial changes on biochemical systems which impact on toxicologic processes are positively enhanced. Lipid metabolism is reduced and, therefore, the potential for lipoperoxidation is reduced. Additionally, activity of enzymes that produce free radicals as byproducts (cytochrome P4502C11) are also reduced. Concurrently, we have shown that the "effective" activity of catalase and the activity of superoxide dismutase (which are required for the detoxification of toxic oxygen radicals) are significantly increased by caloric restriction. The activities of enzymes of drug and xenobiotic metabolism are also altered by caloric restriction. The effect upon activity may be to either decrease or increase activity, dependent upon whether the enzyme activates compounds to intermediates which may be more toxic or whether the enzyme acts to reduce toxicity. We have also shown that caloric restriction may affect the initiation stage of carcinogenesis. Aflatoxin B1 binding to hepatic nuclear DNA was reduced by caloric restriction (caloric restriction reduced both major adducts that are formed upon exposure to aflatoxin B1). caloric restriction also reduced cytochrome P4502C11 which converts aflatoxin B1 to its toxic epoxide, and may partly explain the reduction in binding. These results suggest that caloric restriction may, in part, extend the time to development of degenerative disease by altering basic biochemical mechanisms of toxicity. JF - Advances in experimental medicine and biology AU - Hart, R W AU - Leakey, J E AU - Chou, M AU - Duffy, P H AU - Allaben, W T AU - Feuers, R J AD - National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1992 PY - 1992 DA - 1992 SP - 73 EP - 81 VL - 322 SN - 0065-2598, 0065-2598 KW - Carcinogens KW - 0 KW - Free Radicals KW - Index Medicus KW - Animals KW - Survival Rate KW - Humans KW - Carcinogens -- toxicity KW - Body Weight -- physiology KW - Liver -- metabolism KW - Nutritional Physiological Phenomena KW - Energy Intake KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73334884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Modulation+of+chemical+toxicity+by+modification+of+caloric+intake.&rft.au=Hart%2C+R+W%3BLeakey%2C+J+E%3BChou%2C+M%3BDuffy%2C+P+H%3BAllaben%2C+W+T%3BFeuers%2C+R+J&rft.aulast=Hart&rft.aufirst=R&rft.date=1992-01-01&rft.volume=322&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-23 N1 - Date created - 1992-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Victoria M. Trasko: champion of state-based surveillance of occupational diseases in the United States, 1937 to 1971. AN - 73170857; 1519623 AB - Victoria M. Trasko (1907-1979), a relatively unknown figure to many currently practicing occupational health specialists, was a pioneer in state-based surveillance of occupational diseases in the United States. To highlight her accomplishments during her career with the United States Public Health Service from 1937 to 1971, this report briefly reviews her publications on occupational disease surveillance. Her span of work includes guidelines for state industrial hygiene programs, numbers of workers in state occupational health programs, compilation of state and local laws related to industrial hygiene, proposals for standardized reporting of occupational disease, and analysis of trends in workers' compensation and mortality statistics for occupational diseases. She pilot tested the first state-based model system for occupational disease reporting in the United States. She documented the great difficulty experienced by states in getting physicians to report cases of occupational diseases, and pointed out that surveillance of other existing data sources was worthwhile, at least for some occupational diseases. She was the first to report on the distribution of silicosis cases in the United States by state, industry, and job title. She was the first to comment on mortality trends for the pneumoconioses and to document problems in comparability between different International Classification of Disease (ICD) periods. JF - American journal of industrial medicine AU - Costa, C A AU - Castellan, R M AU - Richards, T B AU - Yaffe, C D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1992 PY - 1992 DA - 1992 SP - 419 EP - 428 VL - 22 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - History of medicine KW - Trasko KW - United States KW - Silicosis -- prevention & control KW - Silicosis -- history KW - History, 20th Century KW - United States Public Health Service -- history KW - Humans KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- history KW - Pneumoconiosis -- history KW - Pneumoconiosis -- prevention & control KW - National Institutes of Health (U.S.) -- history KW - Occupational Health -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73170857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Victoria+M.+Trasko%3A+champion+of+state-based+surveillance+of+occupational+diseases+in+the+United+States%2C+1937+to+1971.&rft.au=Costa%2C+C+A%3BCastellan%2C+R+M%3BRichards%2C+T+B%3BYaffe%2C+C+D&rft.aulast=Costa&rft.aufirst=C&rft.date=1992-01-01&rft.volume=22&rft.issue=3&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-08 N1 - Date created - 1992-10-08 N1 - Date revised - 2017-01-13 N1 - People - Trasko N1 - Last updated - 2017-01-17 N1 - SubjectsTermNotLitGenreText - Trasko ER - TY - JOUR T1 - Binding characteristics of ortho-toluidine to rat hemoglobin and albumin. AN - 73161801; 1514920 AB - The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) were isolated from blood, and OT binding was determined by liquid scintillation counting. For Alb, peak binding occurred at 50 mg/kg at the 4-h time point (15.6 ng OT/mg Alb), while for Hb peak binding was observed at 24 h at the 100 mg/kg dose (23.0 +/- 5.1 ng OT/mg Hb). OT-Alb binding was not linear; however, OT-Hb binding appeared to increase linearly in a dose-dependent manner. Biological half-lives of OT bound to Alb or Hb were observed to be 2.6 and 12.3 days, respectively, after rats were administered a single dose of [14C]OT and sacrificed after 4 h to 28 days. The effect of route of administration on OT-Hb adduct formation was investigated, and approximately a two-fold increase in radioactivity bound to Hb was observed after i.p. administration of 100 mg/kg [14C]OT versus oral intubation. Additional studies were carried out to investigate the effect of microsomal enzyme induction. An increase in OT-Hb binding was seen in rats pretreated with phenobarbital compared to rats pretreated with beta-naphthoflavone or without pretreatment; however, this increase was not statistically significant. These results suggest that OT-Hb and OT-Alb adduct formation may be a valuable biomarker for assessing workplace exposure. JF - Archives of toxicology AU - DeBord, D G AU - Swearengin, T F AU - Cheever, K L AU - Booth-Jones, A D AU - Wissinger, L A AD - Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 231 EP - 236 VL - 66 IS - 4 SN - 0340-5761, 0340-5761 KW - Albumins KW - 0 KW - Biomarkers KW - Blood Proteins KW - Hemoglobins KW - Toluidines KW - 2-toluidine KW - B635MZ0ZLU KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Occupational Exposure KW - Evaluation Studies as Topic KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Blood Proteins -- metabolism KW - Time Factors KW - Biomarkers -- blood KW - Male KW - Albumins -- metabolism KW - Toluidines -- metabolism KW - Hemoglobins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73161801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Binding+characteristics+of+ortho-toluidine+to+rat+hemoglobin+and+albumin.&rft.au=DeBord%2C+D+G%3BSwearengin%2C+T+F%3BCheever%2C+K+L%3BBooth-Jones%2C+A+D%3BWissinger%2C+L+A&rft.aulast=DeBord&rft.aufirst=D&rft.date=1992-01-01&rft.volume=66&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-29 N1 - Date created - 1992-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Much remains to be done. AN - 73129755; 1504179 JF - American Indian and Alaska native mental health research : journal of the National Center AU - Gregory, D AD - Indian Health Service, Portland, Oregon 97204. Y1 - 1992 PY - 1992 DA - 1992 SP - 89 EP - 94; discussion 126-32 VL - 4 IS - 3 SN - 0893-5394, 0893-5394 KW - Psychotropic Drugs KW - 0 KW - Street Drugs KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Health Education -- legislation & jurisprudence KW - Alcoholism -- rehabilitation KW - Indians, North American -- legislation & jurisprudence KW - Health Policy -- legislation & jurisprudence KW - Indians, North American -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73129755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Indian+and+Alaska+native+mental+health+research+%3A+journal+of+the+National+Center&rft.atitle=Much+remains+to+be+done.&rft.au=Gregory%2C+D&rft.aulast=Gregory&rft.aufirst=D&rft.date=1992-01-01&rft.volume=4&rft.issue=3&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=American+Indian+and+Alaska+native+mental+health+research+%3A+journal+of+the+National+Center&rft.issn=08935394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-24 N1 - Date created - 1992-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Exposure to diesel exhaust in the trucking industry and possible relationships with lung cancer. AN - 73045443; 1621697 AB - We previously reported that long-term truck drivers and mechanics in the Teamsters Union had higher lung cancer risks than Teamsters outside the trucking industry. We now summarize results from an industrial hygiene survey of current exposures to diesel exhaust in the trucking industry, and relate these to our prior results pertaining to lung cancer risk. JF - American journal of industrial medicine AU - Steenland, K AU - Silverman, D AU - Zaebst, D AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1992 PY - 1992 DA - 1992 SP - 887 EP - 890 VL - 21 IS - 6 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Fuel Oils KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Air Pollutants, Occupational -- analysis KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Carbon -- analysis KW - Occupational Exposure -- analysis KW - Transportation KW - Lung Neoplasms -- epidemiology KW - Fuel Oils -- adverse effects KW - Occupational Diseases -- epidemiology KW - Lung Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73045443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Exposure+to+diesel+exhaust+in+the+trucking+industry+and+possible+relationships+with+lung+cancer.&rft.au=Steenland%2C+K%3BSilverman%2C+D%3BZaebst%2C+D&rft.aulast=Steenland&rft.aufirst=K&rft.date=1992-01-01&rft.volume=21&rft.issue=6&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-03 N1 - Date created - 1992-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 1993 Aug;24(2):257, 259 [8213854] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Silica exposure in hand grinding steel castings. AN - 72963411; 1317091 AB - Exposure to silica dust was studied in the grinding of castings in a steel foundry that used conventional personal sampling methods and new real-time sampling techniques developed for the identification of high-exposure tasks and tools. Approximately one-third of the personal samples exceeded the National Institute for Occupational Safety and Health recommended exposure limit for crystalline silica, a fraction similar to that identified in other studies of casting cleaning. Of five tools used to clean the castings, the tools with the largest wheels, a 6-in. grinder and a 4-in. cutoff wheel, were shown to be the major sources of dust exposure. Existing dust control consisted of the use of downdraft grinding benches. The size of the casting precluded working at a distance close enough to the grates of the downdraft benches for efficient capture of the grinding dust. In addition, measurements of air recirculated from the downdraft benches indicated that less than one-half of the respirable particles were removed from the contaminated airstream. Previous studies have shown that silica exposures in the cleaning of castings can be reduced or eliminated through the use of mold coatings, which minimize sand burn-in on the casting surface; by application of high-velocity, low-volume exhaust hoods; and by the use of a nonsilica molding aggregate such as olivine. This study concluded that all these methods would be appropriate control options. JF - American Industrial Hygiene Association journal AU - O'Brien, D AU - Froehlich, P A AU - Gressel, M G AU - Hall, R M AU - Clark, N J AU - Bost, P AU - Fischbach, T AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226-1998. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 42 EP - 48 VL - 53 IS - 1 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Evaluation Studies as Topic KW - Environmental Monitoring KW - Air Pollution -- prevention & control KW - Ventilation -- methods KW - Maximum Allowable Concentration KW - Humans KW - Ventilation -- standards KW - Silicon Dioxide -- analysis KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72963411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Silica+exposure+in+hand+grinding+steel+castings.&rft.au=O%27Brien%2C+D%3BFroehlich%2C+P+A%3BGressel%2C+M+G%3BHall%2C+R+M%3BClark%2C+N+J%3BBost%2C+P%3BFischbach%2C+T&rft.aulast=O%27Brien&rft.aufirst=D&rft.date=1992-01-01&rft.volume=53&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-25 N1 - Date created - 1992-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Performance of laboratories measuring silica in the Proficiency Analytical Testing program. AN - 72959590; 1317092 AB - A statistical study was performed on the results reported by laboratories analyzing silica samples in the first 101 rounds of the Proficiency Analytical Testing (PAT) program. Five laboratories participated in the first round of the PAT program in 1972, and participation grew to 130 laboratories before falling to 105 in Round 101. The laboratories use all three of the major methods of analysis: colorimetry, x-ray diffractometry, and infrared spectroscopy. The objectives of the study were to determine bias between methods, the variability associated with the methods, and any changes in bias or variability caused by a number of factors. The colorimetric method has consistently given the lowest results, particularly at higher loadings. X-ray diffractometry results were biased higher than infrared spectroscopy results during one period but not in the following period. Between the two periods, the procedures and materials used to prepare PAT samples changed in a number of ways, but the switch to quartz dust with a smaller particle size is a likely explanation for the bias difference. Generally, silica analyses have improved in precision over time, and this improvement has taken place for all three of the methods. The colorimetric method has shown the poorest precision of the three methods, but, unlike the differences in bias, the differences in precision have diminished considerably over time. Precision estimates from other studies were compared to those from this study to learn more about sources of variability. The largest source of variability, the differences between laboratories, was large even when laboratories used the same method, as they did in a collaborative study of silica methods. JF - American Industrial Hygiene Association journal AU - Shulman, S A AU - Groff, J H AU - Abell, M T AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 49 EP - 56 VL - 53 IS - 1 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - United States KW - Evaluation Studies as Topic KW - Reproducibility of Results KW - X-Ray Diffraction KW - Spectrophotometry, Infrared -- standards KW - Humans KW - Colorimetry -- standards KW - United States Occupational Safety and Health Administration KW - Bias (Epidemiology) KW - Quality Assurance, Health Care KW - Silicon Dioxide -- analysis KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72959590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Performance+of+laboratories+measuring+silica+in+the+Proficiency+Analytical+Testing+program.&rft.au=Shulman%2C+S+A%3BGroff%2C+J+H%3BAbell%2C+M+T&rft.aulast=Shulman&rft.aufirst=S&rft.date=1992-01-01&rft.volume=53&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-25 N1 - Date created - 1992-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fatal occupational injury related to helicopters in the United States 1980-1985. AN - 72855616; 1550537 AB - This paper discusses characteristics of occupational traumatic deaths, caused by helicopters, during 1980-1985. Death certificate data are used to describe demographic characteristics and causes of death. Information from National Transportation Safety Board (NTSB) investigations is used to describe pilot experience and environmental circumstances surrounding the incident. During 1980-1985, 374 worker deaths involving helicopters were identified in the National Traumatic Occupational Fatality (NTOF) database. The majority of deaths resulted from trauma to body organs (including the brain). According to NTSB investigations, 59% of crashes in this study were attributed to pilot error, compared to 16.5% from mechanical failure of the helicopter. Thirty percent of deaths were related to military use of helicopters. While death due to occupational exposure to helicopters is not common, some workers (e.g., helicopter pilots) appear to be at especially high risk. This group should be studied further to develop better strategies for their protection. JF - Aviation, space, and environmental medicine AU - Conroy, C AU - Russell, J C AU - Crouse, W E AU - Bender, T R AU - Holl, J A AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 67 EP - 71 VL - 63 IS - 1 SN - 0095-6562, 0095-6562 KW - Index Medicus KW - Space life sciences KW - United States KW - Drowning KW - Risk Factors KW - Humans KW - Adult KW - Professional Competence KW - Incidence KW - Military Personnel -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Aircraft KW - Accidents, Occupational -- statistics & numerical data KW - Accidents, Aviation -- mortality KW - Accidents, Occupational -- mortality KW - Accidents, Aviation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72855616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+space%2C+and+environmental+medicine&rft.atitle=Fatal+occupational+injury+related+to+helicopters+in+the+United+States+1980-1985.&rft.au=Conroy%2C+C%3BRussell%2C+J+C%3BCrouse%2C+W+E%3BBender%2C+T+R%3BHoll%2C+J+A&rft.aulast=Conroy&rft.aufirst=C&rft.date=1992-01-01&rft.volume=63&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+space%2C+and+environmental+medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-17 N1 - Date created - 1992-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of cyclophosphamide, total body irradiation, and zidovudine on retrovirus proliferation and disease progression in murine AIDS. AN - 72798895; 1310603 AB - Murine acquired immunodeficiency syndrome (MAIDS) develops when C57B1/6 mice are inoculated with LP-BM5 murine leukemia viruses. Disease progression in these animals is characterized by lymphadenopathy, polyclonal B-cell activation, severe immunodeficiency, and death. Mice with MAIDS have been used to examine the efficacy of antiretroviral therapies for possible use in AIDS patients. In the present work, MAIDS mice were employed to test the hypothesis that established retroviral infection might be cured by the combined use of a cytotoxic agent (cyclophosphamide) and total body irradiation--a regimen reported to have successfully cured HIV-1 infection in one AIDS patient. Results indicate that the ablation of retrovirus-infected lymphoid cells reduced but did not eliminate LP-BM5 infection. Moreover, this regimen was no more effective at controlling virus proliferation or preventing the polyclonal IgG activation characteristic of murine AIDS than was AZT alone. JF - AIDS research and human retroviruses AU - Klinman, D M AU - Krieg, A AU - Conover, J AU - Ussery, M A AU - Black, P L AD - Laboratory of Retrovirus Research, CBER, FDA, Bethesda, MD. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 101 EP - 106 VL - 8 IS - 1 SN - 0889-2229, 0889-2229 KW - Zidovudine KW - 4B9XT59T7S KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - AIDS/HIV KW - Lymphocyte Activation -- drug effects KW - Leukemia, Experimental -- radiotherapy KW - B-Lymphocytes -- drug effects KW - Animals KW - Lymphocyte Activation -- radiation effects KW - Leukemia, Experimental -- drug therapy KW - B-Lymphocytes -- radiation effects KW - Mice, Inbred C57BL KW - Mice KW - B-Lymphocytes -- immunology KW - Leukemia, Experimental -- microbiology KW - Female KW - Bone Marrow Transplantation KW - Zidovudine -- therapeutic use KW - Leukemia Virus, Murine -- radiation effects KW - Whole-Body Irradiation KW - Cyclophosphamide -- therapeutic use KW - Virus Replication -- radiation effects KW - Virus Replication -- drug effects KW - Zidovudine -- pharmacology KW - Leukemia Virus, Murine -- drug effects KW - Murine Acquired Immunodeficiency Syndrome -- radiotherapy KW - Murine Acquired Immunodeficiency Syndrome -- microbiology KW - Murine Acquired Immunodeficiency Syndrome -- drug therapy KW - Cyclophosphamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72798895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=Effect+of+cyclophosphamide%2C+total+body+irradiation%2C+and+zidovudine+on+retrovirus+proliferation+and+disease+progression+in+murine+AIDS.&rft.au=Klinman%2C+D+M%3BKrieg%2C+A%3BConover%2C+J%3BUssery%2C+M+A%3BBlack%2C+P+L&rft.aulast=Klinman&rft.aufirst=D&rft.date=1992-01-01&rft.volume=8&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-17 N1 - Date created - 1992-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Review of fluoride benefits and risks: report of the Ad Hoc Subcommittee on Fluoride of the Committee to Coordinate Environmental Health and Related Programs, February 1991 AN - 59604721; 1992-0900657 AB - Review of studies on the cavity-reducing effects vs. carcinogenic risks of fluoridated drinking water. Recommends continued support for optimal fluoridation of drinking water. JF - Atlanta, GA 30333, 1992. 134+ pp. Y1 - 1992///0, PY - 1992 DA - 0, 1992 EP - 134+ PB - Atlanta, GA 30333 KW - Water supply -- Fluoridation KW - Public health -- United States KW - United States -- Health policy KW - Drinking water -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59604721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=134%2B&rft.isbn=&rft.btitle=Review+of+fluoride+benefits+and+risks%3A+report+of+the+Ad+Hoc+Subcommittee+on+Fluoride+of+the+Committee+to+Coordinate+Environmental+Health+and+Related+Programs%2C+February+1991&rft.title=Review+of+fluoride+benefits+and+risks%3A+report+of+the+Ad+Hoc+Subcommittee+on+Fluoride+of+the+Committee+to+Coordinate+Environmental+Health+and+Related+Programs%2C+February+1991&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Atlanta, GA 30333 pa N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - 29. Immunity and vaccine development. AN - 16693080; 2979426 JF - AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC (USA). pp. 491-504. 1992. AU - Ellison, J S AU - Olson, L D AU - Barile, M F A2 - Maniloff, J A2 - McElhaney, RN A2 - Finch, LR A2 - Baseman, JB (eds) Y1 - 1992 PY - 1992 DA - 1992 SP - 14 EP - 504 PB - AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC (USA) SN - 1555810500 KW - Microbiology Abstracts B: Bacteriology KW - vaccines KW - lung KW - immune response (cell-mediated) KW - infection KW - virulence KW - disease control KW - Mycoplasma pneumoniae KW - antigens KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16693080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Ellison%2C+J+S%3BOlson%2C+L+D%3BBarile%2C+M+F&rft.aulast=Ellison&rft.aufirst=J&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=491&rft.isbn=1555810500&rft.btitle=29.+Immunity+and+vaccine+development.&rft.title=29.+Immunity+and+vaccine+development.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2012-02-28 ER - TY - BOOK T1 - Flow-injection assay of enzyme inhibition in fish using immobilized diamine oxidase. AN - 16595785; 3006365 AB - A flow-injection assay for inhibition of diamine oxidase (DAO) is described. Histamine in decomposed fish is detected and used as the enzyme substrate. Sample extracts are doubly injected; one of the two resulting sample zones is passed through a reactor containing DAO immobilized to Sepharose. Histamine is detected sequentially in both the pristine and enzymatically treated zones. The detection chemistry (kinetics-optimized condensation with phthalic dicarboxaldehyde) allows the selective detection of histamine. Subsequent calibration with histamine standard and comparison of the two peak heights allows generic detection of compounds inhibiting the DAO-mediated conversion of histamine. Preliminary data show that the system can detect inhibitors in extracts of decomposed Mahi-Mahi (associated with a Scombroid poisoning outbreak) and that far lower levels of inhibition are observed in fresh fish. Several known inhibitors and competitive substrates of DAO are also tested. JF - Analytica Chimica Acta [ANAL. CHIM. ACTA.]. Vol. 261, no. 1-2. 1992. AU - Hungerford, J M AU - Arefyev, A A Y1 - 1992 PY - 1992 DA - 1992 KW - amine oxidase (copper-containing) KW - analytical techniques KW - biological poisons KW - flow injection assay KW - fluorometry KW - food fish KW - histamine KW - histamines KW - immobilized enzymes KW - quality assurance KW - scombroid poisoning KW - Toxicology Abstracts; ASFA Marine Biotechnology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - enzymatic activity KW - food poisoning KW - seafood KW - Q4 27390:Toxins KW - X 24222:Analytical procedures KW - X 24173:Animals KW - Q4 27260:Immobilization KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16595785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hungerford%2C+J+M%3BArefyev%2C+A+A&rft.aulast=Hungerford&rft.aufirst=J&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Flow-injection+assay+of+enzyme+inhibition+in+fish+using+immobilized+diamine+oxidase.&rft.title=Flow-injection+assay+of+enzyme+inhibition+in+fish+using+immobilized+diamine+oxidase.&rft.issn=00032670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 ER - TY - BOOK T1 - Development of tolerance limits for an industry - ethylene oxide sterilization of medical devices. AN - 16589247; 51792 AB - This paper illustrates a use of probability plots in an unusual application - the development of limits for process parameters for the Ethylene Oxide (EO) sterilization industry. The results of the study provide lower and upper 1% and 10% limits for the values of several parameters. These are point estimate limits for the target values of the process parameters. EO is used to produce the majority of sterile medical devices. Compared with other sterilization procedures, EO sterilization is a poorly understood process. Food and Drug Administration (FDA) investigators collected detailed descriptions of procedures at 262 establishments, both domestic and foreign, in order to obtain a better understanding of industry practices. Probability plots were employed to screen data for outliers and to fit empirical cumulative distributions to process parameters. The plots were useful in identifying relationships among parameters and in developing both univariate and bivariate tolerance limits. This report focuses on the use and interpretation of probability plots for these applications. In December 1990, the FDA issued these limits as guidelines for its investigators in evaluating sterilization cycles employed by medical device manufacturers. The guidelines facilitate FDA investigations by providing a means of identifying processes where proof of the efficacy of the sterilization process is most needed. The limits should benefit EO sterilizers by informing them of where their process fits in the spectrum of other processes. Unusual values of process parameters should alert the sterilizer that this process is not in the mainstream. The limits are intended as guidance for the investigator and the producer. They should not be interpreted as requirements. JF - ASQC, MILWAUKEE, WI (USA). Vol. 46, pp. 741-747. 1992. AU - Madden, Dale A Y1 - 1992 PY - 1992 DA - 1992 SP - 7 EP - 747 PB - ASQC, MILWAUKEE, WI (USA) KW - Biomedical equipment KW - Ethyl oxide sterilization KW - Point estimate limits KW - Process control KW - Statistical methods KW - Sterilization (cleaning) KW - Tolerance limits KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Probability KW - Standards KW - W4 922.1:PROBABILITY THEORY KW - W4 902.2:CODES AND STANDARDS KW - W4 462.1:BIOMEDICAL EQUIPMENT (GENERAL) KW - W4 913.3:QUALITY ASSURANCE AND CONTROL KW - W4 731:AUTOMATIC CONTROL PRINCIPLES AND APPLICATIONS KW - W 30965:Miscellaneous, Reviews KW - W4 922.2:MATHEMATICAL STATISTICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16589247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Biotechnology+Research+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Madden%2C+Dale+A&rft.aulast=Madden&rft.aufirst=Dale&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=741&rft.isbn=&rft.btitle=Development+of+tolerance+limits+for+an+industry+-+ethylene+oxide+sterilization+of+medical+devices.&rft.title=Development+of+tolerance+limits+for+an+industry+-+ethylene+oxide+sterilization+of+medical+devices.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A review of physical exercises recommended for VDT operators. AN - 16491805; 2944578 AB - This paper presents an evaluation of exercises that have been recommended for the prevention of musculoskeletal discomfort among VDT/office workers. 127 individual exercises were analysed for their suitability for performance in VDT workplaces. Additionally, each exercise was judged in terms of its safety and its compliance with principles of physiotherapy. Results showed that, in the majority of cases, the prepared instructions for the exercises were satisfactory and the exercises could be readily performed at the workstation. However, over a third of the exercises were conspicuous and potentially embarrassing to perform, and half would significantly disrupt the work routine. Additionally, a number of the exercises posed potential safety hazards, exacerbated biomechanical stresses common to VDT work, or were contraindicated for persons with certain health problems. These findings suggest a need for greater attention to both the practical and the therapeutic aspects of exercises promoted for VDT users. JF - Applied Ergonomics AU - Lee, K AU - Swanson, N AU - Sauter, S AU - Wickstrom, R AU - Waikar, A AU - Mangum, M AD - NIOSH, Taft Lab., 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 387 EP - 408 VL - 23 IS - 6 SN - 0003-6870, 0003-6870 KW - video display terminals KW - musculoskeletal system KW - exercise KW - Health & Safety Science Abstracts KW - ergonomics KW - occupational health KW - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16491805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=A+review+of+physical+exercises+recommended+for+VDT+operators.&rft.au=Lee%2C+K%3BSwanson%2C+N%3BSauter%2C+S%3BWickstrom%2C+R%3BWaikar%2C+A%3BMangum%2C+M&rft.aulast=Lee&rft.aufirst=K&rft.date=1992-01-01&rft.volume=23&rft.issue=6&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; ergonomics ER - TY - JOUR T1 - A simple method to test condoms for penetration by viruses. AN - 16486155; 2936998 AB - A method by which virus penetration through condoms can be tested with simple, inexpensive equipment is described. The method uses Phi X174 bacteriophage as the challenge virus and physiologically relevant pressure. Penetration by 0.1 mu l (or less) of challenge suspension can be readily detected. As examples, latex and natural-membrane condoms were examined. JF - Applied and Environmental Microbiology AU - Lytle, C D AU - Routson, L B AU - Cyr, W H AD - Div. Life Sci., Cent. Devices and Radiol. Health, FDA, Rockville, MD 20857, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 3180 EP - 3182 VL - 58 IS - 7 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - penetration KW - phage Phi X174 KW - methodology KW - detection KW - condoms KW - latex KW - viruses KW - V 22124:Prophylaxis & control KW - A 01114:Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16486155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=A+simple+method+to+test+condoms+for+penetration+by+viruses.&rft.au=Lytle%2C+C+D%3BRoutson%2C+L+B%3BCyr%2C+W+H&rft.aulast=Lytle&rft.aufirst=C&rft.date=1992-01-01&rft.volume=58&rft.issue=7&rft.spage=3180&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2012-02-28 N1 - SubjectsTermNotLitGenreText - phage Phi X174; condoms; viruses; penetration; detection; latex; methodology ER - TY - JOUR T1 - Consequences of chemical modifications on the free radical reactions of human hemoglobin. AN - 16416254; 2895232 AB - Hemoglobin-based oxygen carriers (HBOCs) are candidates for use as blood substitutes and resuscitation fluids. HBOCs of specific types differ in their ability to generate or interact with free radicals. The differences do not correlate with oxygen affinity. Comparisons with unmodified human hemoglobin, HbA sub(0), were carried out with two cross-linked derivatives; HbA-FMDA, produced by the reaction of human oxyhemoglobin with fumaryl monodibromoaspirin, and HbA-DBBF, produced by the reaction of human deoxyhemoglobin with bis(3,5-dibromosalicyl) fumarate. The HBOCs also differ in rates of hemoglobin-catalyzed NADPH oxidation and aniline hydroxylation, reactions mediated by reactive oxygen species. The stereochemical differences brought about by chemical cross-linking alter the ability of HBOCs to generate radicals and to react with activated oxygen species. The ability of hemoglobin to produce activated species of oxygen can be enhanced or suppressed independently of oxygen affinity. JF - Archives of Biochemistry and Biophysics AU - Alayash, AI AU - Fratantoni, J C AU - Bonaventura, C AU - Bonaventura, J AU - Bucci, E AD - Cent. Biol. Eval. and Res., FDA, 8800 Rockville Pike, Build. 29, Rm. B-10, Bethesda, MD 20892, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 114 EP - 120 VL - 298 IS - 1 SN - 0003-9861, 0003-9861 KW - chemical modification KW - effects on KW - free radicals KW - haemoglobin KW - man KW - reaction KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16416254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Biochemistry+and+Biophysics&rft.atitle=Consequences+of+chemical+modifications+on+the+free+radical+reactions+of+human+hemoglobin.&rft.au=Alayash%2C+AI%3BFratantoni%2C+J+C%3BBonaventura%2C+C%3BBonaventura%2C+J%3BBucci%2C+E&rft.aulast=Alayash&rft.aufirst=AI&rft.date=1992-01-01&rft.volume=298&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Archives+of+Biochemistry+and+Biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Effective local exhaust ventilation for controlling formaldehyde exposures during embalming. AN - 16373922; 2877297 AB - Previous studies have found that formaldehyde exposures to embalmers during the embalming process exceeded current occupational health criteria and standards. There are currently just over 20,000 mortuaries in the United States, employing 75,000 people. A research study was conducted to develop and evaluate a local exhaust ventilation system to control formaldehyde exposures. The control design that was developed consisted of a pair of 6-ft-long slot hoods placed on each side of the embalming table. Through a series of laboratory tests, an optimum flow rate (20 m super(3)/min) was determined for the local exhaust ventilation system. The final design was field tested at a college of mortuary science to determine its effectiveness. JF - Applied Occupational & Environmental Hygiene AU - Gressel, M G AU - Hughes, R T AD - Dep. Health and Hum. Serv., Public Health Serv., Cent. Dis. Control, NIOSH, 4676 Columbia Parkway, Mailstop R-5, Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 840 EP - 845 VL - 7 IS - 12 SN - 1047-322X, 1047-322X KW - embalming KW - mortuaries KW - Health & Safety Science Abstracts KW - ventilation KW - indoor environments KW - air pollution control KW - formaldehyde KW - occupational exposure KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - H SI0.9.4:VENTILATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16373922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Effective+local+exhaust+ventilation+for+controlling+formaldehyde+exposures+during+embalming.&rft.au=Gressel%2C+M+G%3BHughes%2C+R+T&rft.aulast=Gressel&rft.aufirst=M&rft.date=1992-01-01&rft.volume=7&rft.issue=12&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational exposure; formaldehyde; ventilation; indoor environments; air pollution control ER - TY - JOUR T1 - Metal-based formulations with high microbicidal activity. AN - 16339121; 2842313 AB - Substances were evaluated for their relative potencies in inactivating Junin virus, Escherichia coli , and spores Bacillus subtilis . Under the conditions of our test, glutaraldehyde was the most efficient agent among all substances currently recommended for disinfecting and sterilizing medical devices. Either copper or iron ions by themselves were able to inactivate virus with an efficiency similar to that of substances currently used for disinfection and sterilization. The microbicidal effect of metals, however, was enhanced further by the addition of peroxide. The mixtures of copper and peroxide described here were more efficient than glutaraldehyde in inactivating viruses and bacteria. The addition of a metal chelator to metal-peroxide mixtures further increased the microbicidal potency of the reagent. The formulations described in this study should be harmless to people but able to quickly and efficiently inactivate microorganisms, particularly viruses. JF - Applied and Environmental Microbiology AU - Sagripanti, J-L AD - Mol. Biol. Branch (HFZ-113), Cent. Devices and Radiol. Health, FDA, Rockville, MD 20857, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 3157 EP - 3162 VL - 58 IS - 9 SN - 0099-2240, 0099-2240 KW - glutaraldehyde KW - copper KW - iron KW - hydrogen peroxide KW - chelators KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - disinfectants KW - Junin virus KW - spores KW - metals KW - Escherichia coli KW - antimicrobial agents KW - A 01069:Antimicrobial & microbiocidal KW - V 22100:Antiviral agents KW - J 02803:Antiseptics and disinfectants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16339121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Metal-based+formulations+with+high+microbicidal+activity.&rft.au=Sagripanti%2C+J-L&rft.aulast=Sagripanti&rft.aufirst=J-L&rft.date=1992-01-01&rft.volume=58&rft.issue=9&rft.spage=3157&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus subtilis; Escherichia coli; Junin virus; metals; antimicrobial agents; disinfectants; spores ER - TY - JOUR T1 - Differentiation of a rapidly growing, scotochromogenic, polycyclic-aromatic-hydrocarbon-metabolizing strain of Mycobacterium sp. from other known Mycobacterium species. AN - 16269427; 2792822 AB - A rapidly-growing, acid-alcohol fast, scotochromogenic, polycyclic-aromatic-hydrocarbon-degrading Mycobacterium sp. isolate, Pyr-1, which was different from known Mycobacterium species based on biochemical tests, was further analyzed to compare its mycolic acids, cellular proteins, and nucleic acids with those of known species. Mass spectral analysis of the mycolic acids of Mycobacterium sp. Pyr-1 indicated that its mycolic acids were C sub(60)H sub(120)O sub(3) and C sub(62)H sub(124)O sub(3). The mycolic acid pattern was unique, most closely resembling M. austroafricanum) but also resembling M. parafortuitum and M. gilvum . Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of soluble cellular proteins also readily differentiated this isolate from other species. JF - Archives of Microbiology AU - Rafii, F AU - Butler, W R AU - Cerniglia, CE AD - Div. Microbiol., Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 512 EP - 520 VL - 157 IS - 6 SN - 0302-8933, 0302-8933 KW - mycolic acid KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - biodegradation KW - Mycobacterium KW - characterization KW - mass spectroscopy KW - identification KW - polycyclic aromatic hydrocarbons KW - taxonomy KW - A 01063:Utilization KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16269427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Microbiology&rft.atitle=Differentiation+of+a+rapidly+growing%2C+scotochromogenic%2C+polycyclic-aromatic-hydrocarbon-metabolizing+strain+of+Mycobacterium+sp.+from+other+known+Mycobacterium+species.&rft.au=Rafii%2C+F%3BButler%2C+W+R%3BCerniglia%2C+CE&rft.aulast=Rafii&rft.aufirst=F&rft.date=1992-01-01&rft.volume=157&rft.issue=6&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Archives+of+Microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium; identification; taxonomy; mass spectroscopy; characterization; polycyclic aromatic hydrocarbons; biodegradation ER - TY - JOUR T1 - Real-time personal monitoring in the workplace using radio telemetry. AN - 16159679; 2697485 AB - A case study involving a furniture refinisher's exposure to methylene chloride is described here to demonstrate the utility of radio telemetry. The worker carried a radio transmitter that was attached to an air quality analyzer. Relative methylene chloride exposures were remotely observed on a video monitor throughout the day. Increases in exposure levels due to job tasks, work practices, and emission sources were immediately identified so that corrective action could be taken. JF - Applied Occupational & Environmental Hygiene AU - Kovein, R J AU - Hentz, P A AD - NIOSH, Div. Phys. Sci. and Eng., Eng. Control Technol. Branch, 4676 Columbia Parkw.-R5, Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 168 EP - 173 VL - 7 IS - 3 SN - 1047-322X, 1047-322X KW - air quality KW - methylene chloride KW - Pollution Abstracts KW - fumes KW - occupational health KW - remote sensing KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16159679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Real-time+personal+monitoring+in+the+workplace+using+radio+telemetry.&rft.au=Kovein%2C+R+J%3BHentz%2C+P+A&rft.aulast=Kovein&rft.aufirst=R&rft.date=1992-01-01&rft.volume=7&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - remote sensing; occupational health; fumes ER - TY - JOUR T1 - Control of wood dust from rotational hand-held sanders. AN - 16147931; 2700204 AB - An association between nasal cancer and other health effects and occupations involving exposure to wood dust has been clearly established in the literature. Therefore, it was deemed necessary to conduct research to develop new improved methods to control this dust. This article reports on the research that has been conducted by investigations at the National Institute for Occupational Safety and Health (NIOSH) on rotational hand-held sanders. A new control system was developed to be used in conjunction with existing controls that are used on these sanders, which consist of an aspirator and a perforated sanding disc pad. The new control system includes additional suction applied to the sander body and a specially designed, slotted sanding disc pad to relieve the increased pressing of the sander to the sanded surface imposed by the increased vacuum. The newly designed sanding disc pad also captures wood dust from the sanded surface directly at the pad periphery. The laboratory the new control system reduced the wood dust emissions by over 90 percent compared with emissions from the aspirator-controlled sanders that are currently in use. JF - APPL. OCCUP. ENVIRON. HEALTH. AU - Hampl, V AU - Topmiller, J L AU - Watkins, D S AU - Murdock, D J AD - NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 263 EP - 270 VL - 7 IS - 4 KW - occupational health KW - emission control KW - hand-held sanders KW - Health & Safety Science Abstracts; Pollution Abstracts KW - wood KW - dust KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI1.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16147931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=APPL.+OCCUP.+ENVIRON.+HEALTH.&rft.atitle=Control+of+wood+dust+from+rotational+hand-held+sanders.&rft.au=Hampl%2C+V%3BTopmiller%2C+J+L%3BWatkins%2C+D+S%3BMurdock%2C+D+J&rft.aulast=Hampl&rft.aufirst=V&rft.date=1992-01-01&rft.volume=7&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=APPL.+OCCUP.+ENVIRON.+HEALTH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; wood ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945343 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945338 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 6 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945288 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 6 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945286 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 1 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945283 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945257 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945246 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945236 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945235 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945203 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945197 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 6 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945191 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and the Epidemiology of Liver Cirrhosis AN - 1474334663 JF - Alcohol Health and Research World AU - Smart, Reginald G AU - Mann, Robert E Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 217 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+the+Epidemiology+of+Liver+Cirrhosis&rft.au=Smart%2C+Reginald+G%3BMann%2C+Robert+E&rft.aulast=Smart&rft.aufirst=Reginald&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism and Tuberculosis AN - 1474334564 JF - Alcohol Health and Research World AU - Jacobson, Jeffrey M Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 39 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism+and+Tuberculosis&rft.au=Jacobson%2C+Jeffrey+M&rft.aulast=Jacobson&rft.aufirst=Jeffrey&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism and Asymmetries of Brain Function AN - 1474334541 JF - Alcohol Health and Research World AU - Oscar-Berman, Marlene Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 273 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism+and+Asymmetries+of+Brain+Function&rft.au=Oscar-Berman%2C+Marlene&rft.aulast=Oscar-Berman&rft.aufirst=Marlene&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Instruction Manual for Making an Embryo: How Does Alcohol Affect Embryonic Development? AN - 1474334516 JF - Alcohol Health and Research World AU - Hogan, Brigid L M AU - Barnes, Joseph Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 324 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Instruction+Manual+for+Making+an+Embryo%3A+How+Does+Alcohol+Affect+Embryonic+Development%3F&rft.au=Hogan%2C+Brigid+L+M%3BBarnes%2C+Joseph&rft.aulast=Hogan&rft.aufirst=Brigid+L&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on Labor Market Success: Income, Earnings, Labor Supply, and Occupation AN - 1474334477 JF - Alcohol Health and Research World AU - Mullahy, John AU - Sindelar, Jody L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 134 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+Labor+Market+Success%3A+Income%2C+Earnings%2C+Labor+Supply%2C+and+Occupation&rft.au=Mullahy%2C+John%3BSindelar%2C+Jody+L&rft.aulast=Mullahy&rft.aufirst=John&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol-Related Chronic Disease AN - 1474334454 JF - Alcohol Health and Research World AU - Arria, Amelia M AU - THIEL, DAVID H. VAN Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 209 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol-Related+Chronic+Disease&rft.au=Arria%2C+Amelia+M%3BTHIEL%2C+DAVID+H.+VAN&rft.aulast=Arria&rft.aufirst=Amelia&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - A Description of Clients Using Employee Assistance Programs AN - 1474334448 JF - Alcohol Health and Research World AU - Blum, Terry C AU - Roman, Paul M Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 120 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=A+Description+of+Clients+Using+Employee+Assistance+Programs&rft.au=Blum%2C+Terry+C%3BRoman%2C+Paul+M&rft.aulast=Blum&rft.aufirst=Terry&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Immunity, Malnutrition, and Alcohol AN - 1474334372 JF - Alcohol Health and Research World AU - Mendenhall, Charles L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 23 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Immunity%2C+Malnutrition%2C+and+Alcohol&rft.au=Mendenhall%2C+Charles+L&rft.aulast=Mendenhall&rft.aufirst=Charles&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Expanding Boundaries of Alcohol Research AN - 1474334355 JF - Alcohol Health and Research World AU - Gordis, Enoch Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 255 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Expanding+Boundaries+of+Alcohol+Research&rft.au=Gordis%2C+Enoch&rft.aulast=Gordis&rft.aufirst=Enoch&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 31 Association of Alcohol Problems with Risk for AIDS in the 1988 National Health Interview Survey AN - 1474334336 JF - Alcohol Health and Research World AU - Stinson, Frederick S AU - Debakey, Samar F AU - Grant, Bridget F AU - Dawson, Deborah A Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 245 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+31+Association+of+Alcohol+Problems+with+Risk+for+AIDS+in+the+1988+National+Health+Interview+Survey&rft.au=Stinson%2C+Frederick+S%3BDebakey%2C+Samar+F%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Immune System: Mechanisms That Counteract Disease AN - 1474334321 JF - Alcohol Health and Research World AU - Grossman, Charles J AU - Wilson, Eve J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Immune+System%3A+Mechanisms+That+Counteract+Disease&rft.au=Grossman%2C+Charles+J%3BWilson%2C+Eve+J&rft.aulast=Grossman&rft.aufirst=Charles&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol, Memory, and Molecules AN - 1474321893 JF - Alcohol Health and Research World AU - Browning, Michael D AU - Hoffer, Barry J AU - Dunwiddie, Thomas V Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 280 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol%2C+Memory%2C+and+Molecules&rft.au=Browning%2C+Michael+D%3BHoffer%2C+Barry+J%3BDunwiddie%2C+Thomas+V&rft.aulast=Browning&rft.aufirst=Michael&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and the Immune System AN - 1474321844 JF - Alcohol Health and Research World AU - Roselle, Gary A Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 16 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+the+Immune+System&rft.au=Roselle%2C+Gary+A&rft.aulast=Roselle&rft.aufirst=Gary&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genomic Imprinting: Parental Origin Effects on Gene Expression AN - 1474321842 JF - Alcohol Health and Research World AU - Kirkness, Ewen F AU - Durcan, Michael J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 312 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genomic+Imprinting%3A+Parental+Origin+Effects+on+Gene+Expression&rft.au=Kirkness%2C+Ewen+F%3BDurcan%2C+Michael+J&rft.aulast=Kirkness&rft.aufirst=Ewen&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - General Glossary AN - 1474321825 JF - Alcohol Health and Research World Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 46 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=General+Glossary&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Overview of Epidemiology with Applications to Alcohol Research AN - 1474321780 JF - Alcohol Health and Research World AU - Harford, Thomas C Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 177 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Overview+of+Epidemiology+with+Applications+to+Alcohol+Research&rft.au=Harford%2C+Thomas+C&rft.aulast=Harford&rft.aufirst=Thomas&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Latent Variable Modeling in Epidemiology AN - 1474321710 JF - Alcohol Health and Research World AU - MUTHÉN, BENGT O Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 286 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Latent+Variable+Modeling+in+Epidemiology&rft.au=MUTH%C3%89N%2C+BENGT+O&rft.aulast=MUTH%C3%89N&rft.aufirst=BENGT&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Effects of Prenatal Exposure to Alcohol AN - 1474321708 JF - Alcohol Health and Research World AU - Day, Nancy L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 238 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Effects+of+Prenatal+Exposure+to+Alcohol&rft.au=Day%2C+Nancy+L&rft.aulast=Day&rft.aufirst=Nancy&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Increased Behavioral Risk for AIDS AN - 1474321696 JF - Alcohol Health and Research World AU - Cooper, M Lynne Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 64 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Increased+Behavioral+Risk+for+AIDS&rft.au=Cooper%2C+M+Lynne&rft.aulast=Cooper&rft.aufirst=M&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol Consumption AN - 1474321639 JF - Alcohol Health and Research World AU - Midanik, Lorraine T AU - Room, Robin Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 183 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol+Consumption&rft.au=Midanik%2C+Lorraine+T%3BRoom%2C+Robin&rft.aulast=Midanik&rft.aufirst=Lorraine&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Abuse and Dependence from a Psychiatric Epidemiologic Perspective AN - 1474321506 JF - Alcohol Health and Research World AU - Bucholz, Kathleen K Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 197 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Abuse+and+Dependence+from+a+Psychiatric+Epidemiologic+Perspective&rft.au=Bucholz%2C+Kathleen+K&rft.aulast=Bucholz&rft.aufirst=Kathleen&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Potential Role of Alcohol in Human Immunodeficiency Virus Infection AN - 1474321491 JF - Alcohol Health and Research World AU - Kruger, Thomas E AU - Jerrells, Thomas R Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 57 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Potential+Role+of+Alcohol+in+Human+Immunodeficiency+Virus+Infection&rft.au=Kruger%2C+Thomas+E%3BJerrells%2C+Thomas+R&rft.aulast=Kruger&rft.aufirst=Thomas&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism Treatment for Employees and Family Members: Its Effect on Health Care Costs AN - 1474321477 JF - Alcohol Health and Research World AU - Holder, Harold D AU - Cunningham, Donald W Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 149 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism+Treatment+for+Employees+and+Family+Members%3A+Its+Effect+on+Health+Care+Costs&rft.au=Holder%2C+Harold+D%3BCunningham%2C+Donald+W&rft.aulast=Holder&rft.aufirst=Harold&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Molecular Modeling: Computer-Assisted Innovations in Drug Design - An Interview With Robert Pearlstein, Ph.D. AN - 1474321351 JF - Alcohol Health and Research World AU - Wilson, Eve J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 293 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Molecular+Modeling%3A+Computer-Assisted+Innovations+in+Drug+Design+-+An+Interview+With+Robert+Pearlstein%2C+Ph.D.&rft.au=Wilson%2C+Eve+J&rft.aulast=Wilson&rft.aufirst=Eve&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholism: A Complex Genetic Disease AN - 1474321349 JF - Alcohol Health and Research World AU - Crabbe, John C AU - Goldman, David Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 297 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholism%3A+A+Complex+Genetic+Disease&rft.au=Crabbe%2C+John+C%3BGoldman%2C+David&rft.aulast=Crabbe&rft.aufirst=John&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Consumption in Relation to Risk of Cancers of the Breast and Large Bowel AN - 1474321315 JF - Alcohol Health and Research World AU - Longnecker, Matthew P Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 223 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Consumption+in+Relation+to+Risk+of+Cancers+of+the+Breast+and+Large+Bowel&rft.au=Longnecker%2C+Matthew+P&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol-Related Trauma AN - 1474321194 JF - Alcohol Health and Research World AU - CHERPITEL, CHERYL J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 191 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol-Related+Trauma&rft.au=CHERPITEL%2C+CHERYL+J&rft.aulast=CHERPITEL&rft.aufirst=CHERYL&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 30 Prevalence of DSM - III - R Alcohol Abuse and/or Dependence Among Selected Occupations: United States, 1988 AN - 1474321186 JF - Alcohol Health and Research World AU - Stinson, Frederick S AU - Debakey, Samar Farha AU - Steffens, Rebecca A Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 165 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+30+Prevalence+of+DSM+-+III+-+R+Alcohol+Abuse+and%2For+Dependence+Among+Selected+Occupations%3A+United+States%2C+1988&rft.au=Stinson%2C+Frederick+S%3BDebakey%2C+Samar+Farha%3BSteffens%2C+Rebecca+A&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Job-Treatment Balance in Employee Assistance Programs AN - 1474317817 JF - Alcohol Health and Research World AU - Sonnenstuhl, William J Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 129 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Job-Treatment+Balance+in+Employee+Assistance+Programs&rft.au=Sonnenstuhl%2C+William+J&rft.aulast=Sonnenstuhl&rft.aufirst=William&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Treating the Employed Alcoholic: Which Interventions Work? AN - 1474317800 JF - Alcohol Health and Research World AU - Walsh, Diana Chapman AU - Hingson, Ralph W AU - Merrigan, Daniel M AU - LEVENSON, SUZETTE MORELOCK Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 140 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Treating+the+Employed+Alcoholic%3A+Which+Interventions+Work%3F&rft.au=Walsh%2C+Diana+Chapman%3BHingson%2C+Ralph+W%3BMerrigan%2C+Daniel+M%3BLEVENSON%2C+SUZETTE+MORELOCK&rft.aulast=Walsh&rft.aufirst=Diana&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Drinking Patterns and Problems Among Women in Paid Employment AN - 1474317752 JF - Alcohol Health and Research World AU - Shore, Elsie R Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 160 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Drinking+Patterns+and+Problems+Among+Women+in+Paid+Employment&rft.au=Shore%2C+Elsie+R&rft.aulast=Shore&rft.aufirst=Elsie&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Gene Transfer and Gene Therapy AN - 1474317729 JF - Alcohol Health and Research World AU - Nielsen, David A AU - Goldman, David Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 304 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Gene+Transfer+and+Gene+Therapy&rft.au=Nielsen%2C+David+A%3BGoldman%2C+David&rft.aulast=Nielsen&rft.aufirst=David&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Retinoic Acid, Embryonic Development, and Alcohol-Induced Birth Defects AN - 1474317648 JF - Alcohol Health and Research World AU - Pullarkat, Raju K AU - Azar, Beth Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 317 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Retinoic+Acid%2C+Embryonic+Development%2C+and+Alcohol-Induced+Birth+Defects&rft.au=Pullarkat%2C+Raju+K%3BAzar%2C+Beth&rft.aulast=Pullarkat&rft.aufirst=Raju&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Reports Alcohol, Arrhythmia, and Sudden Death AN - 1474317605 JF - Alcohol Health and Research World AU - Friedman, Howard S Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 87 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Reports+Alcohol%2C+Arrhythmia%2C+and+Sudden+Death&rft.au=Friedman%2C+Howard+S&rft.aulast=Friedman&rft.aufirst=Howard&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Cancer AN - 1474317599 JF - Alcohol Health and Research World AU - Garro, Anthony J AU - Espina, Noel AU - Lieber, Charles S Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 81 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Cancer&rft.au=Garro%2C+Anthony+J%3BEspina%2C+Noel%3BLieber%2C+Charles+S&rft.aulast=Garro&rft.aufirst=Anthony&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Bacterial Pneumonia AN - 1474317573 JF - Alcohol Health and Research World AU - Nelson, Steve AU - Shellito, Judd AU - Mason, Carol AU - Summer, Warren R Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 73 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Bacterial+Pneumonia&rft.au=Nelson%2C+Steve%3BShellito%2C+Judd%3BMason%2C+Carol%3BSummer%2C+Warren+R&rft.aulast=Nelson&rft.aufirst=Steve&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - A Cultural Approach to Conceptualizing Alcohol and the Workplace AN - 1474317466 JF - Alcohol Health and Research World AU - Ames, Genevieve M AU - Janes, Craig Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 112 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=A+Cultural+Approach+to+Conceptualizing+Alcohol+and+the+Workplace&rft.au=Ames%2C+Genevieve+M%3BJanes%2C+Craig&rft.aulast=Ames&rft.aufirst=Genevieve&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - BEHAVIORAL SCIENCE: Decisions About Alcohol: Prevention, Intervention, and Policy AN - 1474317433 JF - Alcohol Health and Research World AU - Fischhoff, Baruch Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 257 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=BEHAVIORAL+SCIENCE%3A+Decisions+About+Alcohol%3A+Prevention%2C+Intervention%2C+and+Policy&rft.au=Fischhoff%2C+Baruch&rft.aulast=Fischhoff&rft.aufirst=Baruch&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The New Physics of Chaos: Can It Help Us Understand the Effects of Alcohol? AN - 1474317419 JF - Alcohol Health and Research World AU - Ehlers, Cindy L Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 267 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+New+Physics+of+Chaos%3A+Can+It+Help+Us+Understand+the+Effects+of+Alcohol%3F&rft.au=Ehlers%2C+Cindy+L&rft.aulast=Ehlers&rft.aufirst=Cindy&rft.date=1992-01-01&rft.volume=16&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Viral Hepatitis and Alcoholism AN - 1474317306 JF - Alcohol Health and Research World AU - Rosman, Alan S Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 48 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Viral+Hepatitis+and+Alcoholism&rft.au=Rosman%2C+Alan+S&rft.aulast=Rosman&rft.aufirst=Alan&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Who Is Following the Recovering Alcoholic? Examining the Role of Followup in Employee Assistance Programs AN - 1474317097 JF - Alcohol Health and Research World AU - Erfurt, John C AU - Foote, Andrea Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 154 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Who+Is+Following+the+Recovering+Alcoholic%3F+Examining+the+Role+of+Followup+in+Employee+Assistance+Programs&rft.au=Erfurt%2C+John+C%3BFoote%2C+Andrea&rft.aulast=Erfurt&rft.aufirst=John&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Work-Related Risk Factors Associated with Alcohol Abuse AN - 1474317093 JF - Alcohol Health and Research World AU - Trice, Harrison M Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 106 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Work-Related+Risk+Factors+Associated+with+Alcohol+Abuse&rft.au=Trice%2C+Harrison+M&rft.aulast=Trice&rft.aufirst=Harrison&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol Consumption and Dependence Across Occupations in the United States AN - 1474316966 JF - Alcohol Health and Research World AU - Parker, Douglas A AU - Harford, Thomas C Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 97 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol+Consumption+and+Dependence+Across+Occupations+in+the+United+States&rft.au=Parker%2C+Douglas+A%3BHarford%2C+Thomas+C&rft.aulast=Parker&rft.aufirst=Douglas&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Fetal Alcohol Syndrome and Functioning of the Immune System AN - 1474316813 JF - Alcohol Health and Research World AU - Giberson, Pamela K AU - Weinberg, Joanne Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 29 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Fetal+Alcohol+Syndrome+and+Functioning+of+the+Immune+System&rft.au=Giberson%2C+Pamela+K%3BWeinberg%2C+Joanne&rft.aulast=Giberson&rft.aufirst=Pamela&rft.date=1992-01-01&rft.volume=16&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Epidemiology of Alcohol-Related Interpersonal Violence AN - 1474316812 JF - Alcohol Health and Research World AU - Martin, Susan E Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 230 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 16 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Epidemiology+of+Alcohol-Related+Interpersonal+Violence&rft.au=Martin%2C+Susan+E&rft.aulast=Martin&rft.aufirst=Susan&rft.date=1992-01-01&rft.volume=16&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Oxidative conversion of 6-fluorobenzo(c)phenanthrene to its K-region oxide by liver microsomes from 3-methylcholanthrene treated rats: reversal of stereoselectivity of cytochrome P-450c due to the influence of fluoro group. AN - 72583424; 1764102 AB - We have shown earlier that metabolism of carcinogenic 6-fluorobenzo(c)-phenanthrene by liver microsomes of 3-methylcholanthrene treated rats generate K-region oxide as the major metabolite, while no K-region oxide survives in benzo(c)-phenanthrene metabolism under identical conditions. To understand the influence of fluoro group on the generation of K-region oxide from this hydrocarbon, we have determined the enantiomeric composition and absolute configuration of the metabolic 6-fluorobenzo(c)phen-anthrene-7,8-oxide. Interestingly, the microsomal cytochrome P-450c forms predominantly the 5R,6S enantiomer from B(c)Ph, while it exhibits a reversal of stereoselectivity with 6-fluorobenzo(c)phenanthrene forming predominantly the 7S,8R enantiomer. We have attributed this observation to an unfavourable interaction of the fluoro group with the hydrophobic binding pocket of the isozyme. JF - Biochemical and biophysical research communications AU - Prasad, G K AU - Thakker, D R AD - Laboratory of Molecular Pharmacology, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/12/31/ PY - 1991 DA - 1991 Dec 31 SP - 1516 EP - 1523 VL - 181 IS - 3 SN - 0006-291X, 0006-291X KW - Carcinogens KW - 0 KW - Hydrocarbons, Fluorinated KW - Phenanthrenes KW - 6-fluorobenzo(c)phenanthrene KW - 34236-47-0 KW - Methylcholanthrene KW - 56-49-5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Rats KW - Animals KW - Biotransformation KW - Isomerism KW - Circular Dichroism KW - Male KW - Chromatography, High Pressure Liquid KW - Binding Sites KW - Phenanthrenes -- metabolism KW - Carcinogens -- metabolism KW - Methylcholanthrene -- pharmacology KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Hydrocarbons, Fluorinated -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72583424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Oxidative+conversion+of+6-fluorobenzo%28c%29phenanthrene+to+its+K-region+oxide+by+liver+microsomes+from+3-methylcholanthrene+treated+rats%3A+reversal+of+stereoselectivity+of+cytochrome+P-450c+due+to+the+influence+of+fluoro+group.&rft.au=Prasad%2C+G+K%3BThakker%2C+D+R&rft.aulast=Prasad&rft.aufirst=G&rft.date=1991-12-31&rft.volume=181&rft.issue=3&rft.spage=1516&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-07 N1 - Date created - 1992-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Communicating with patients about their medications. AN - 72461737; 1944456 JF - The New England journal of medicine AU - Kessler, D A AD - Food and Drug Administration, Rockville, MD 20857. Y1 - 1991/12/05/ PY - 1991 DA - 1991 Dec 05 SP - 1650 EP - 1652 VL - 325 IS - 23 SN - 0028-4793, 0028-4793 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Attitude of Health Personnel KW - Drug Information Services -- standards KW - Patient Compliance KW - Drug-Related Side Effects and Adverse Reactions KW - Pamphlets KW - Counseling -- standards KW - Drug Labeling -- standards KW - Patient Education as Topic -- methods KW - Communication KW - Pharmaceutical Services -- standards KW - Physician-Patient Relations KW - Drug Therapy -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Communicating+with+patients+about+their+medications.&rft.au=Kessler%2C+D+A&rft.aulast=Kessler&rft.aufirst=D&rft.date=1991-12-05&rft.volume=325&rft.issue=23&rft.spage=1650&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-11 N1 - Date created - 1991-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Principles and costs in the regulation of microbially contaminated foods. AN - 72751750; 1822932 AB - A strong code of regulations exists in the United States to control pathogens and other microbes in food and drink. Despite strict enforcement, food-borne illness persists. Parasitic animals in foods are particularly difficult to detect because there are no simple culture systems for their multiplication and because sanitary measures against fecal contamination are ineffective against parasite species transmitted by other routes. To attain a high degree of safety, total processing of foods by heat- and/or irradiation-pasteurization combined with sterile packaging may be required. The cost of regulating food-borne microbes, while large, is probably surpassed by the cost of food-borne illness (estimated to be US$50 billion annually), resulting in net savings. JF - The Southeast Asian journal of tropical medicine and public health AU - Jackson, G J AD - Division of Microbiology, US Food and Drug Administration, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 382 EP - 383 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Costs and Cost Analysis KW - Food Handling -- standards KW - Parasites -- isolation & purification KW - Legislation, Food -- economics KW - Parasitic Diseases -- prevention & control KW - Food Parasitology KW - Parasitic Diseases -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72751750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Principles+and+costs+in+the+regulation+of+microbially+contaminated+foods.&rft.au=Jackson%2C+G+J&rft.aulast=Jackson&rft.aufirst=G&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Testing for food-borne parasites, their metabolic products and symbionts. AN - 72749830; 1822919 AB - Microscopic animals associated with foods include free-living and saprophytic invertebrates, parasites of hosts other than humans, and parasitic animals specifically designated as food-borne that can infect a human host by the gastrointestinal route. The first general method used to screen for food-borne species was digestion with pepsin and hydrochloric acid at 36 degrees C, based on the "artificial stomach juice" technique for recovering larvae of the nematode Trichinella spiralis from muscle. This method selects for forms capable of surviving a mammalian digestive enzyme at mammalian temperatures. It has been used successfully to recover a variety of food-borne helminths, not only from mammalian flesh but also from fish, shellfish and molluscs, and can be adapted to greatly reduce the "background of living animals" associated with soils and the crops grown in them. However, not all animal forms that survive digestion are food-borne parasites, and all that succumb are not necessarily noninfectious. Methodology to test for food-borne parasites is, in general, not as efficient as that for food-borne bacteria. Recent developments in food parasitology indicate a need to identify not only the parasite, but also its metabolic products and associated symbionts. JF - The Southeast Asian journal of tropical medicine and public health AU - Jackson, G J AD - Division of Microbiology, United States Food and Drug Administration, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 334 EP - 336 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Pepsin A KW - EC 3.4.23.1 KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - Meat KW - Animals KW - Symbiosis KW - Humans KW - Fishes KW - Shellfish KW - Hydrochloric Acid -- metabolism KW - Pepsin A -- metabolism KW - Parasites -- metabolism KW - Parasites -- isolation & purification KW - Food Parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72749830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Testing+for+food-borne+parasites%2C+their+metabolic+products+and+symbionts.&rft.au=Jackson%2C+G+J&rft.aulast=Jackson&rft.aufirst=G&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isolation of parasites on fruits and vegetables. AN - 72749194; 1822873 AB - The current FDA method to recover parasites from fruits and vegetables is derived from procedures used to isolate parasitic protozoa from water. A 1kg portion of fruit or vegetable is divided into 200 g subportions. The subportions are sequentially processed in a sonic cleaning bath with 1.5 liters of detergent solution (1% sodium dodecyl sulfate, 0.1% Tween 80) and sonicated for 10 minutes. As each subsample is removed, it is thoroughly drained. After this sonic treatment, the wash water is collected in a polypropylene beaker, transferred to 50 ml polypropylene centrifuge tubes and centrifuged for 15 min at 1500 x g. The sediment is consolidated into one tube along with two rinsings of each tube. The final sediment is fixed in 4% formaldehyde for 10 minutes before examination for parasites. Indirect fluorescent antibody is applied to stain the parasites (Giardia spp. and/or Cryptosporidium spp.) by using commercial kits when available. If a large quantity of extraneous matter is contained in the sediment it may be reduced by layering on Sheather's fluid and centrifuging at 1500 x g for 15 minutes. The supernatant is collected and washed twice in distilled water. This procedure is adequate for protozoa and nonoperculate helminth eggs; operculate helminth eggs may be cleaned by extraction with ethyl acetate. When cabbage and lettuce were seeded at 1 organism/g, the rate of recovery for Cryptosporidium parvum with the FDA method was 1%. When cabbage was seeded at 1 egg/g and 10 eggs/g, the average rate of recovery of decorticated eggs of Ascaris sp. or untreated Trichuris sp. was 10%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Southeast Asian journal of tropical medicine and public health AU - Bier, J W AD - Division of Microbiology, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 144 EP - 145 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Index Medicus KW - Ascaris -- isolation & purification KW - Animals KW - Trichuris -- isolation & purification KW - Giardia -- isolation & purification KW - Cryptosporidium -- isolation & purification KW - Sonication KW - Brassica -- parasitology KW - Vegetables -- parasitology KW - Parasites -- isolation & purification KW - Food Parasitology KW - Fruit -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72749194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Isolation+of+parasites+on+fruits+and+vegetables.&rft.au=Bier%2C+J+W&rft.aulast=Bier&rft.aufirst=J&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Priority-based assessment of food additives database of the U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition. AN - 72746798; 1820284 AB - The priority-based assessment of food additives (PAFA) is a database maintained by the U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition. PAFA contains extensive administrative, chemical, and toxicological information on 1685 regulated direct food additives. The database also has limited administrative and chemical information on an additional 1236 direct additives. The total 2921 substances represent everything added to food in the United States. PAFA contains up to 150 different kinds of information about each chemical. Administrative and chemical information includes Chemical Abstracts Service Registry numbers, Code of Federal Regulations citations, the annual usage and estimated daily U.S. human consumption, the Joint Committee on Food Additives Allowable Daily Intakes, the FDA Redbook structure categories of the chemicals, and their technical effects. Toxicology information shows the type of studies done for each chemical, the species of animals tested, the toxicological effects observed and the sites where they were seen, the lowest doses that cause a toxicological effect in each study, a source citation, and other types of related information. JF - Environmental health perspectives AU - Benz, R D AU - Irausquin, H AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 85 EP - 89 VL - 96 SN - 0091-6765, 0091-6765 KW - Food Additives KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Administration, Oral KW - Animals KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - United States Food and Drug Administration KW - Food Additives -- chemistry KW - Databases, Factual KW - Food Additives -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72746798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Priority-based+assessment+of+food+additives+database+of+the+U.S.+Food+and+Drug+Administration+Center+for+Food+Safety+and+Applied+Nutrition.&rft.au=Benz%2C+R+D%3BIrausquin%2C+H&rft.aulast=Benz&rft.aufirst=R&rft.date=1991-12-01&rft.volume=96&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-04 N1 - Date created - 1992-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Regul Toxicol Pharmacol. 1984 Mar;4(1):37-56 [6718769] Regul Toxicol Pharmacol. 1987 Jun;7(2):160-8 [3303168] Regul Toxicol Pharmacol. 1986 Jun;6(2):181-91 [3726179] Regul Toxicol Pharmacol. 1985 Jun;5(2):152-74 [3839589] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of synergism/antagonism between HIV-1 antibody-positive human sera and soluble CD4 in blocking HIV-1 binding and infectivity. AN - 72713561; 1687500 AB - We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. This allows the assessment of synergism/antagonism at any desired level of effect. Using three assays (whole virus binding to CD4 cells, neutralization of HIV infectivity, and binding of purified gp120 to solid-phase sCD4), we generally observed additive effects or slight synergism between antibody and sCD4 in inhibiting gp120-CD4 interaction. We used a fourth assay to measure the irreversible inactivation of HIV infectivity by sCD4, a property that can also be mediated by antibody but with considerably less potency than sCD4. The reduction in HIV infectivity mediated by mixtures of sCD4 and antibody was always equal to or greater than the arithmetic sum of the reductions by either agent alone. The relevant antiviral effects of sCD4 and anti-HIV sera may include reversible blockage of receptor binding, irreversible inactivation of HIV infectivity, and in the case of antibody, additional reactions that are independent of receptor binding. Although predictions concerning the in vivo situation are speculative, we find no evidence in vitro for antagonism between sCD4 and antibody with respect to the net effect of the two in blocking HIV binding and infectivity. JF - AIDS research and human retroviruses AU - Kennedy, M S AU - Orloff, S AU - Ibegbu, C C AU - Odell, C D AU - Maddon, P J AU - McDougal, J S AD - Immunology Branch, Centers for Disease Control, U.S. Public Health Service, Atlanta GA 30333. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 975 EP - 981 VL - 7 IS - 12 SN - 0889-2229, 0889-2229 KW - Antigens, CD4 KW - 0 KW - HIV Antibodies KW - HIV Envelope Protein gp120 KW - Immune Sera KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Binding, Competitive KW - Neutralization Tests KW - Drug Synergism KW - Male KW - HIV-1 -- metabolism KW - HIV-1 -- immunology KW - HIV Antibodies -- immunology KW - Immune Sera -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV-1 -- physiology KW - CD4-Positive T-Lymphocytes -- microbiology KW - Antigens, CD4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72713561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=Analysis+of+synergism%2Fantagonism+between+HIV-1+antibody-positive+human+sera+and+soluble+CD4+in+blocking+HIV-1+binding+and+infectivity.&rft.au=Kennedy%2C+M+S%3BOrloff%2C+S%3BIbegbu%2C+C+C%3BOdell%2C+C+D%3BMaddon%2C+P+J%3BMcDougal%2C+J+S&rft.aulast=Kennedy&rft.aufirst=M&rft.date=1991-12-01&rft.volume=7&rft.issue=12&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-12 N1 - Date created - 1992-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Confirmation of oxytetracycline, tetracycline and chlortetracycline residues in milk by particle beam liquid chromatography/mass spectrometry. AN - 72707984; 1812989 AB - A method using particle beam liquid chromatography/mass spectrometry was developed for the confirmation of oxytetracycline, tetracycline and chlortetracycline residues in bovine milk. This method is one of the first to apply particle beam technology to the confirmation of animal drug residues in food products for regulatory purposes. The milk is centrifuged, using molecular weight cut-off filters to remove components of 25,000 daltons and above from the milk. The filtrate is passed through a C-18 sample preparation cartridge which retains the tetracyclines. After the columns are washed with water, the tetracyclines are eluted with 0.1 M oxalic acid in methanol and concentrated. The compounds are separated on a Novapak C-18 column with a methanol-oxalic acid-acetonitrile mobile phase. Negative chemical ionization with selective ion monitoring is used to identify the tetracyclines. The procedure was used to confirm the presence of each tetracycline at 100 ng ml-1 in fortified and incurred milk samples. JF - Biological mass spectrometry AU - Kijak, P J AU - Leadbetter, M G AU - Thomas, M H AU - Thompson, E A AD - Food and Drug Administration, Division of Veterinary Medical Research, Beltsville, Maryland 20705. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 789 EP - 795 VL - 20 IS - 12 SN - 1052-9306, 1052-9306 KW - Tetracycline KW - F8VB5M810T KW - Chlortetracycline KW - WCK1KIQ23Q KW - Oxytetracycline KW - X20I9EN955 KW - Index Medicus KW - Animals KW - Gas Chromatography-Mass Spectrometry -- methods KW - Drug Residues -- analysis KW - Chlortetracycline -- analysis KW - Tetracycline -- analysis KW - Milk -- analysis KW - Oxytetracycline -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72707984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+mass+spectrometry&rft.atitle=Confirmation+of+oxytetracycline%2C+tetracycline+and+chlortetracycline+residues+in+milk+by+particle+beam+liquid+chromatography%2Fmass+spectrometry.&rft.au=Kijak%2C+P+J%3BLeadbetter%2C+M+G%3BThomas%2C+M+H%3BThompson%2C+E+A&rft.aulast=Kijak&rft.aufirst=P&rft.date=1991-12-01&rft.volume=20&rft.issue=12&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Biological+mass+spectrometry&rft.issn=10529306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-12 N1 - Date created - 1992-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancing the quality of epidemiologic studies. AN - 72682814; 1800679 AB - Three principles can improve epidemiologic studies (1) Conduct open scientific review of research protocols and final reports, (2) Disseminate study results to all appropriate parties, and (3) Incorporate new scientific methods into the research and utilize expertise from other disciplines. The procedures we describe are used within the Industrywide Studies Branch of the National Institute for Occupational Safety and Health to implement these principles. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Fingerhut, M A AU - Halperin, W E AU - Okun, A H AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1233 EP - 1235 VL - 33 IS - 12 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - United States KW - Occupational Exposure KW - Humans KW - Peer Review KW - National Institute for Occupational Safety and Health (U.S.) KW - Clinical Protocols KW - Research Design -- trends KW - Epidemiologic Methods KW - Research Design -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72682814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Enhancing+the+quality+of+epidemiologic+studies.&rft.au=Fingerhut%2C+M+A%3BHalperin%2C+W+E%3BOkun%2C+A+H&rft.aulast=Fingerhut&rft.aufirst=M&rft.date=1991-12-01&rft.volume=33&rft.issue=12&rft.spage=1233&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-17 N1 - Date created - 1992-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of air for tertiary amine catalysts used in the polyurethane foam industry. AN - 72635555; 1781428 JF - American Industrial Hygiene Association journal AU - Foley, G D AU - Tucker, S P AU - Cooper, C V AD - National Institute for Occupational Safety and Health, Cincinnati, OH 44226. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - A664 EP - A665 VL - 52 IS - 12 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Ethyl Ethers KW - Morpholines KW - Piperazines KW - Polyurethanes KW - triethylenediamine KW - X8M57R0JS5 KW - Index Medicus KW - United States KW - Evaluation Studies as Topic KW - Humans KW - United States Occupational Safety and Health Administration KW - Air Pollutants, Occupational -- analysis KW - Ethyl Ethers -- analysis KW - Piperazines -- analysis KW - Morpholines -- analysis KW - Environmental Monitoring -- methods KW - Chemical Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72635555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Analysis+of+air+for+tertiary+amine+catalysts+used+in+the+polyurethane+foam+industry.&rft.au=Foley%2C+G+D%3BTucker%2C+S+P%3BCooper%2C+C+V&rft.aulast=Foley&rft.aufirst=G&rft.date=1991-12-01&rft.volume=52&rft.issue=12&rft.spage=A664&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-09 N1 - Date created - 1992-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Environmental study of firefighters. AN - 72614624; 1768008 AB - A study of firefighter exposures was undertaken at the request of the U.S. Fire Administration. This work was part of a larger study which included field evaluation of the performance of the self-contained breathing apparatus (SCBA) worn by firefighters during structural firefighting. Measurements were made for a variety of contaminants including CO, CO2, benzene, HCN, HCl, H2SO4, HF, acrolein, CH4, formaldehyde and PNAs. Many of the analyses were performed by collection of bag samples followed by Fourier transform infrared spectroscopy using a field mobile spectrometer. Measurements were also made using solid sorbent tubes and direct-reading meters. Sampling was done both during the knockdown and during overhaul phases of structural firefighting. Also, in order to estimate exposures including those when the SCBAs were worn, measurements were made both inside and outside the SCBA facepiece. Carbon monoxide was the most common contaminant found during knockdown, and about 10% of the samples were greater than 1500 ppm. Formaldehyde, acrolein, hydrogen chloride, hydrogen cyanide, sulphuric acid and hydrogen fluoride all exceeded their respective short-term exposure limits (STEL) on some occasions. Approximately 50% of the knockdown samples for acrolein exceeded the STEL. During overhaul, when masks were usually not worn, many of the contaminants found during knockdown were detected, but typically at much lower concentrations. Inside-mask sampling data suggest that exposure to low concentrations of a variety of compounds is occurring but this is believed to be principally the result of early mask removal or of non-use during knockdown rather than of leakage. The three basic sampling approaches (bag sampling, sorbent tubes and direct-reading meters) proved in this study to be complementary and served to maximize our ability to detect and quantify a wide range of combustion products. JF - The Annals of occupational hygiene AU - Jankovic, J AU - Jones, W AU - Burkhart, J AU - Noonan, G AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 581 EP - 602 VL - 35 IS - 6 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Spectrophotometry, Infrared KW - Evaluation Studies as Topic KW - Environmental Monitoring KW - Humans KW - Respiratory Protective Devices -- standards KW - Air Pollutants, Occupational -- analysis KW - Fires -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72614624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Environmental+study+of+firefighters.&rft.au=Jankovic%2C+J%3BJones%2C+W%3BBurkhart%2C+J%3BNoonan%2C+G&rft.aulast=Jankovic&rft.aufirst=J&rft.date=1991-12-01&rft.volume=35&rft.issue=6&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dietary exposure to furocoumarins. AN - 72613452; 1771268 AB - Natural furocoumarins, some of which are carcinogenic, are widespread components of the diet which are frequently consumed. Because of the paucity of samples, the wide scatter of analytical values, and other limitations in the data, only broad conclusions can be drawn. Most of the exposure is from limes, with smaller amounts coming from other citrus and umbelliferous food plants. The per capita exposure is estimated to be 1.3 mg per day. Exposure can be reduced through controlling stress in growing plants and stored food products. Because furocoumarins are one class of a large group of chemicals in a defensive system essential to plant survival, their total eradication is not possible. Further research is needed to assess their health risk. JF - Regulatory toxicology and pharmacology : RTP AU - Wagstaff, D J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 261 EP - 272 VL - 14 IS - 3 SN - 0273-2300, 0273-2300 KW - Furocoumarins KW - 0 KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Health Status Indicators KW - Aged, 80 and over KW - Adult KW - Environmental Exposure KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Food Contamination KW - Furocoumarins -- analysis KW - Furocoumarins -- adverse effects KW - Diet -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72613452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Dietary+exposure+to+furocoumarins.&rft.au=Wagstaff%2C+D+J&rft.aulast=Wagstaff&rft.aufirst=D&rft.date=1991-12-01&rft.volume=14&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish. AN - 72597398; 1765324 AB - The pharmacokinetics, tissue distribution and excretion of 14C-labelled aflatoxin B1 (AFB1) were examined after oral administration (250 micrograms/kg body weight) in channel catfish (Ictalurus punctatus). Plasma concentrations of parent AFB1 were best described by a one-compartment pharmacokinetic model, in which peak plasma concentration (503 ppb) occurred at 4.1 hr after dosing. The absorption and elimination half-lives were 1.5 and 3.7 hr, respectively. AFB1 was highly bound (95%) to plasma proteins. Concentrations of 14C (in AFB1 equivalents) measured in the tissues were highest at 4 hr, ranging from 596 ppb in the plasma to 40 ppb in the muscle. AFB1 residues were rapidly depleted; at 24 hr the concentrations in the plasma and muscle were 32 and less than 5 ppb, respectively. Concentrations in the bile exceeded 2000 ppb (at 24 hr), whereas the highest concentration in the urine was 51 ppb (4-6-hr collection interval). Renal and biliary excretion accounted for less than 5% of the administered dose, indicating incomplete absorption. Pharmacokinetic modelling and tissue data demonstrate a very low potential for the accumulation of AFB1 and its metabolites in the edible flesh of channel catfish through the consumption of AFB1-contaminated feed. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Plakas, S M AU - Loveland, P M AU - Bailey, G S AU - Blazer, V S AU - Wilson, G L AD - Division of Seafood Research, Food and Drug Administration, Dauphin Island, AL 36528. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 805 EP - 808 VL - 29 IS - 12 SN - 0278-6915, 0278-6915 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Administration, Oral KW - Animals KW - Ictaluridae KW - Scintillation Counting KW - Spectrophotometry, Ultraviolet KW - Tissue Distribution KW - Chromatography, High Pressure Liquid KW - Aflatoxin B1 -- urine KW - Aflatoxin B1 -- pharmacokinetics KW - Aflatoxin B1 -- blood KW - Aflatoxin B1 -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72597398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Tissue+disposition+and+excretion+of+14C-labelled+aflatoxin+B1+after+oral+administration+in+channel+catfish.&rft.au=Plakas%2C+S+M%3BLoveland%2C+P+M%3BBailey%2C+G+S%3BBlazer%2C+V+S%3BWilson%2C+G+L&rft.aulast=Plakas&rft.aufirst=S&rft.date=1991-12-01&rft.volume=29&rft.issue=12&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-20 N1 - Date created - 1992-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Considerations when measuring urinary albumin: precision, substances that may interfere, and conditions for sample storage. AN - 72596580; 1764788 AB - The measurement of small but abnormal amounts of albumin in urine is important in evaluating kidney disease in people with diabetes mellitus, hypertension, or possible adverse health effects from exposure to nephrotoxins. Routine laboratory methods for measuring albumin are not sensitive enough to measure the amounts that are significant in urine (less than 30 mg/L). In our laboratory we used three immunoassays for measuring urinary albumin: enzyme-linked immunosorbent assay (EIA), radioimmunoassay (RIA), and immunoturbidimetric assay (IT). We calculated the CVs of the three methods, investigated potential interfering substances at three times their normal concentrations, and stored urine under different conditions to find the best way to protect the sample until assay. The potential interferents we checked were transferrin, urea, beta 2-microglobulin, retinol-binding protein, creatinine, kappa and lambda light chains, IgG, hemoglobin, ketone, and glucose. The stability study involved two study temperatures (-20 and -70 degrees C) and four treatments (centrifuging or filtering, before or after storage). We found the following: the RIA had the lowest CV; the results from the interference study showed no interference from normal physiological concentrations of the substances investigated; storage at -70 degrees C regardless of the treatment should be adequate to prevent loss of albumin immunoreactivity. JF - Clinical chemistry AU - MacNeil, M L AU - Mueller, P W AU - Caudill, S P AU - Steinberg, K K AD - Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 2120 EP - 2123 VL - 37 IS - 12 SN - 0009-9147, 0009-9147 KW - Index Medicus KW - Radioimmunoassay -- standards KW - Nephelometry and Turbidimetry -- standards KW - Immunoenzyme Techniques -- standards KW - Humans KW - Preservation, Biological KW - Temperature KW - Time Factors KW - Quality Control KW - Albuminuria -- urine KW - Immunoassay -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72596580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Considerations+when+measuring+urinary+albumin%3A+precision%2C+substances+that+may+interfere%2C+and+conditions+for+sample+storage.&rft.au=MacNeil%2C+M+L%3BMueller%2C+P+W%3BCaudill%2C+S+P%3BSteinberg%2C+K+K&rft.aulast=MacNeil&rft.aufirst=M&rft.date=1991-12-01&rft.volume=37&rft.issue=12&rft.spage=2120&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions. AN - 72565733; 1747934 AB - Both nitroreduction and ring-oxidation appear to be important pathways for the in vivo metabolic activation of 1-nitropyrene (1-NP), a tumorigenic environmental contaminant. Previous studies, however, suggest that ring-oxidation is primarily responsible for the S9-mediated mutagenicity of 1-NP in Chinese hamster ovary (CHO) cells. In this study, an anaerobic rat liver S9 metabolizing system was used to facilitate the nitroreduction of 1-NP to a mutagen in repair-proficient CHO-K1-BH4 cells and excision-repair-deficient CHO-UV5 cells, and results using this system were compared with those obtained from the aerobic S9 metabolism of 1-NP. Anaerobic S9 metabolism of 2.5-15 micrograms/ml of 1-NP produced 15 +/- 3 mutants/10(6) cells/microgram 1-NP/ml with CHO-UV5 cells and 3 +/- 1 mutants/10(6) cells/microgram 1-NP/ml with CHO-K1-BH4 cells (different at P less than 0.001). When the assays were conducted with CHO-K1-BH4 cells, the number of mutants produced by 1-NP using aerobic treatment conditions was similar to that found using anaerobic conditions. In contrast, the aerobic incubations resulted in significantly fewer 1-NP-induced mutants than the anaerobic treatments when the assays were conducted with CHO-UV5 cells. Examination of the metabolites produced during these incubations indicated that under anaerobic conditions 1-NP was efficiently converted to 1-aminopyrene, while aerobic metabolism resulted in the formation of 1-NP phenols and dihydrodiols. DNA adduct analysis by 32P-postlabeling revealed that 1-NP treatment using the anaerobic procedure produced CHO-cell adducts by the reduction of 1-NP to N-hydroxy-1-aminopyrene, while aerobic incubations resulted in adducts produced by other metabolic pathways, probably involving ring-oxidation. These findings indicate that the S9-mediated metabolism of 1-NP under anaerobic conditions produces mutations and DNA adducts in CHO cells that are the result of nitroreductive metabolism. The results with aerobic S9 metabolism were consistent with the previous conclusion that this system mediated the mutagenicity of 1-NP in CHO cells mainly through the generation of ring-oxidized metabolites. The combination of the anaerobic and aerobic S9 metabolism procedures provides a new approach for evaluating the mutagenicity of nitropolycyclic aromatic hydrocarbons in mammalian cells. JF - Carcinogenesis AU - Thornton-Manning, J R AU - Smith, B A AU - Beland, F A AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 2317 EP - 2323 VL - 12 IS - 12 SN - 0143-3334, 0143-3334 KW - Liver Extracts KW - 0 KW - Mutagens KW - Pyrenes KW - DNA KW - 9007-49-2 KW - Oxygen KW - S88TT14065 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Mutagenicity Tests KW - Anaerobiosis -- physiology KW - Aerobiosis -- physiology KW - Oxygen -- metabolism KW - DNA -- metabolism KW - Cricetinae KW - CHO Cells -- metabolism KW - Mutagens -- metabolism KW - Pyrenes -- metabolism KW - Liver Extracts -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72565733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=S9-mediated+metabolism+of+1-nitropyrene+to+a+mutagen+in+Chinese+hamster+ovary+cells+by+ring-oxidation+under+aerobic+conditions+and+by+nitroreduction+under+anaerobic+conditions.&rft.au=Thornton-Manning%2C+J+R%3BSmith%2C+B+A%3BBeland%2C+F+A%3BHeflich%2C+R+H&rft.aulast=Thornton-Manning&rft.aufirst=J&rft.date=1991-12-01&rft.volume=12&rft.issue=12&rft.spage=2317&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-22 N1 - Date created - 1992-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Representativeness of deaths identified through the injury-at-work item on the death certificate: implications for surveillance. AN - 72543337; 1836109 AB - This research investigated the accuracy of the injury-at-work item on the death certificate for surveillance of occupational injury deaths in Oklahoma during 1985 and 1986. Representativeness of occupational injury deaths identified by death certificates was assessed by comparing these deaths with all occupational injury deaths identified through death certificates, workers' compensation reports, medical examiner reports, and OSHA records for categories of occupation, industry, and external causes of death. Certain external causes of death (e.g., motor vehicle traffic deaths) and certain occupations (e.g., farming) and industries (agriculture and services) are more often underidentified through death certificates. The findings of this study support Baker's observation that no single data source contains all deaths or all the data elements necessary to describe occupational injury deaths. Data sources may be combined to improve representativeness through more complete case ascertainment. JF - American journal of public health AU - Russell, J AU - Conroy, C AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WVa. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1613 EP - 1618 VL - 81 IS - 12 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Coroners and Medical Examiners -- statistics & numerical data KW - Humans KW - United States Occupational Safety and Health Administration -- statistics & numerical data KW - Databases, Factual -- standards KW - Cause of Death KW - Evaluation Studies as Topic KW - Industry -- statistics & numerical data KW - Occupations -- statistics & numerical data KW - Workers' Compensation -- statistics & numerical data KW - Medical Record Linkage -- standards KW - Female KW - Male KW - Oklahoma -- epidemiology KW - Death Certificates KW - Accidents, Occupational -- mortality KW - Wounds and Injuries -- mortality KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72543337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Representativeness+of+deaths+identified+through+the+injury-at-work+item+on+the+death+certificate%3A+implications+for+surveillance.&rft.au=Russell%2C+J%3BConroy%2C+C&rft.aulast=Russell&rft.aufirst=J&rft.date=1991-12-01&rft.volume=81&rft.issue=12&rft.spage=1613&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-16 N1 - Date created - 1992-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1988 Sep;78(9):1215-7 [3407824] Am J Public Health. 1976 Jul;66(7):649-54 [937611] J Occup Med. 1989 Oct;31(10):847-51 [2607383] J Occup Med. 1989 Apr;31(4):339-46 [2715840] World Health Stat Q. 1988;41(1):11-8 [3269210] J Occup Med. 1988 Nov;30(11):868-72 [3230433] Scand J Work Environ Health. 1988;14 Suppl 1:90-2 [3393894] N Z Med J. 1987 Jan 28;100(816):1-6 [3468389] Am J Public Health. 1987 Dec;77(12):1524-7 [3674251] Am J Public Health. 1987 Oct;77(10):1290-3 [3631362] Am J Public Health. 1987 Oct;77(10):1285-9 [3631361] J Occup Med. 1986 Feb;28(2):100-2 [3754006] Public Health Rep. 1985 May-Jun;100(3):329-33 [3923543] Public Health Rep. 1985 May-Jun;100(3):325-8 [3923542] Am J Epidemiol. 1990 Jan;131(1):132-42 [2403465] J Forensic Sci. 1990 Jul;35(4):932-7 [2391482] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Am J Public Health. 1990 Feb;80(2):198-200 [2297065] JAMA. 1982 Aug 13;248(6):692-7 [7097919] Am J Epidemiol. 1988 Oct;128(4):806-20 [3048086] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Update on breast implants. AN - 72532649; 1746397 JF - American family physician AU - Rheinstein, P H AU - Hoffman, F A AD - U.S. Food and Drug Administration, Rockville, Maryland. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 2227 EP - 2229 VL - 44 IS - 6 SN - 0002-838X, 0002-838X KW - Gels KW - 0 KW - Polyurethanes KW - Silicones KW - polyurethane foam KW - 9009-54-5 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Physicians, Family KW - Patient Education as Topic KW - Risk Factors KW - Humans KW - Physician's Role KW - Polyurethanes -- adverse effects KW - Female KW - United States Food and Drug Administration KW - Mammaplasty -- adverse effects KW - Silicones -- adverse effects KW - Prostheses and Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72532649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Update+on+breast+implants.&rft.au=Rheinstein%2C+P+H%3BHoffman%2C+F+A&rft.aulast=Rheinstein&rft.aufirst=P&rft.date=1991-12-01&rft.volume=44&rft.issue=6&rft.spage=2227&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - National Medical Expenditure Survey: health insurance, use of health services, and health care expenditures T2 - AHCPR pubn. no. 92-0017 Research findings 12 AN - 59597557; 1992-0612606 AB - Preliminary national estimates of personal, civilian health care use, and expenditures; findings from the 1987 Survey. JF - Nat Tech Info Service, December 1991. 18 pp. AU - Lefkowitz, D AU - Monheit, A Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 18 PB - Nat Tech Info Service KW - United States -- Medical sector KW - Medical service -- Costs -- United States KW - Health surveys -- United States KW - Medical service -- Costs KW - Health insurance -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59597557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lefkowitz%2C+D%3BMonheit%2C+A&rft.aulast=Lefkowitz&rft.aufirst=D&rft.date=1991-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=National+Medical+Expenditure+Survey%3A+health+insurance%2C+use+of+health+services%2C+and+health+care+expenditures&rft.title=National+Medical+Expenditure+Survey%3A+health+insurance%2C+use+of+health+services%2C+and+health+care+expenditures&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Nat Tech Info Service U.S. $17; elsewhere $34 N1 - Document feature - bibl(s), table(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Microbial indicators of sediment contamination in deepwater canyons of the continental shelf AN - 52678173; 1997-065680 JF - Eos, Transactions, American Geophysical Union AU - Small, E B AU - Cooper, R A AU - Gaines, J AU - Nerad, T AU - Sawyer, T AU - Anonymous Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 83 PB - American Geophysical Union, Washington, DC VL - 72 IS - 51, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - thallophytes KW - Lindenkohl Canyon KW - Block Canyon KW - Veatch Canyon KW - marine sediments KW - Hudson Canyon KW - sediments KW - Lydonia Canyon KW - Baltimore Canyon KW - Northwest Atlantic KW - Plantae KW - pollution KW - Eastern U.S. KW - submarine canyons KW - Munson Canyon KW - deep-water environment KW - Wilmington Canyon KW - bacteria KW - Toms Canyon KW - continental shelf KW - North Atlantic KW - Atlantic Ocean KW - microorganisms KW - 07:Oceanography KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52678173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Microbial+indicators+of+sediment+contamination+in+deepwater+canyons+of+the+continental+shelf&rft.au=Small%2C+E+B%3BCooper%2C+R+A%3BGaines%2C+J%3BNerad%2C+T%3BSawyer%2C+T%3BAnonymous&rft.aulast=Small&rft.aufirst=E&rft.date=1991-12-01&rft.volume=72&rft.issue=51%2C+Suppl.&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1992 ocean sciences meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; bacteria; Baltimore Canyon; Block Canyon; continental shelf; deep-water environment; Eastern U.S.; Hudson Canyon; Lindenkohl Canyon; Lydonia Canyon; marine sediments; microorganisms; Munson Canyon; North Atlantic; Northwest Atlantic; Plantae; pollution; sediments; submarine canyons; thallophytes; Toms Canyon; United States; Veatch Canyon; Wilmington Canyon ER - TY - JOUR T1 - Cytochrome P-450-dependent metabolism in alveolar type II epithelial cells: modulation by platelet-activating factor. AN - 72500512; 1958697 AB - Platelet-activating factor (PAF), an ether lipid mediator released from activated pulmonary phagocytes, was evaluated for its ability to affect cytochrome P-450-dependent activities in isolated rat alveolar type II cells. The data indicate that at non-toxic doses, PAF caused an increase in beta-naphthoflavone (BNF) inducible/alpha-naphthoflavone (ANF) sensitive ethoxyphenoxazone deethylase (EtOPx'ase) activity. At high concentrations of PAF, inhibition of both EtOPx'ase and metyrapone (MP) sensitive benzyloxyphenoxazone debenzylase (BzOPx'ase) activities and aggregation of type II cells were observed. The PAF analogs, lyso-PAF and enantio-PAF, exhibited actions similar to those observed with PAF. PAF-induced enhancement of EtOPx'ase activity required the presence of intact cells, whereas at high PAF concentrations decreased enzyme activities were observed in both intact cell and sonicated cell preparations. The data thus suggest that xenobiotic metabolism in alveolar type II cells can be modified by an inflammatory mediator, such as PAF, produced by alveolar phagocytes. JF - Biochimica et biophysica acta AU - Rabovsky, J AU - Pailes, W H AU - Judy, D J AU - Castranova, V AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505. Y1 - 1991/11/12/ PY - 1991 DA - 1991 Nov 12 SP - 223 EP - 229 VL - 1095 IS - 3 SN - 0006-3002, 0006-3002 KW - Platelet Activating Factor KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Oxidoreductases KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP2B1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Oxidoreductases -- metabolism KW - Cell Aggregation -- drug effects KW - In Vitro Techniques KW - Epithelium -- metabolism KW - Male KW - Structure-Activity Relationship KW - Mixed Function Oxygenases -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Platelet Activating Factor -- physiology KW - Platelet Activating Factor -- chemistry KW - Pulmonary Alveoli -- cytology KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72500512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Cytochrome+P-450-dependent+metabolism+in+alveolar+type+II+epithelial+cells%3A+modulation+by+platelet-activating+factor.&rft.au=Rabovsky%2C+J%3BPailes%2C+W+H%3BJudy%2C+D+J%3BCastranova%2C+V&rft.aulast=Rabovsky&rft.aufirst=J&rft.date=1991-11-12&rft.volume=1095&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-09 N1 - Date created - 1992-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of laboratory tests for immune biomarkers in environmental health studies concerned with exposure to indoor air pollutants. AN - 72758814; 1821385 AB - The immune system is likely to be involved in some of the health effects caused by certain indoor air exposures, and immune biomarkers can help determine which exposures and health effects have important immune components. However, the lack of standardized laboratory tests for most human immune markers and the many confounding variables that can influence them makes interpretation of results for exposure and disease end points uncertain. This paper presents an overview of the immune system and the considerations involved in using tests for immune markers in clinical epidemiology studies, particularly those concerned with indoor air exposures. Careful study design, well-characterized laboratory methods, and rigorous documentation of exposure status are required to determine the predictive value of such tests. Clinical tests currently available for some immune markers could help identify and characterize both irritative and hypersensitivity reactions to indoor air pollutants. Newer tests developed in research settings might provide more incisive indicators of immune status that could help identify exposure, susceptibility, or preclinical disease states, but their methodologies must be refined and tested in multicenter studies before they can be used reliably in public health applications. JF - Environmental health perspectives AU - Vogt, R F AD - Division of Environmental Health Laboratory Sciences, U.S. Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 85 EP - 91 VL - 95 SN - 0091-6765, 0091-6765 KW - Air Pollutants KW - 0 KW - Biomarkers KW - Index Medicus KW - Immunity, Cellular KW - Humans KW - Antibody Formation KW - Air Pollution, Indoor -- adverse effects KW - Environmental Monitoring -- standards KW - Immune System -- physiology KW - Immune System -- immunology KW - Air Pollutants -- adverse effects KW - Immunoassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72758814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Use+of+laboratory+tests+for+immune+biomarkers+in+environmental+health+studies+concerned+with+exposure+to+indoor+air+pollutants.&rft.au=Vogt%2C+R+F&rft.aulast=Vogt&rft.aufirst=R&rft.date=1991-11-01&rft.volume=95&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-20 N1 - Date created - 1992-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int Arch Allergy Appl Immunol. 1988;85(3):278-87 [3350607] Toxicol Ind Health. 1988 Dec;4(4):411-30 [3188041] Environ Res. 1987 Aug;43(2):290-307 [3608934] J Allergy Clin Immunol. 1987 Jun;79(6):919-27 [3584747] Allergy. 1986 Sep;41(7):520-5 [3789333] J Allergy Clin Immunol. 1986 Nov;78(5 Pt 2):1035-9 [3782664] N Engl Reg Allergy Proc. 1985 Spring;6(2):140-9 [3870494] N Engl Reg Allergy Proc. 1985 Spring;6(2):126-34 [3870492] N Engl J Med. 1990 Aug 9;323(6):357-65 [2370887] Am Rev Respir Dis. 1990 Sep;142(3):594-601 [2202248] Science. 1989 Jan 6;243(4887):83-5 [2911721] Annu Rev Pharmacol Toxicol. 1987;27:23-49 [3555316] Postgrad Med J. 1988;64 Suppl 4:111-9 [3076928] Int Arch Allergy Appl Immunol. 1987;82(3-4):238-43 [2437039] Cytometry. 1989 May;10(3):294-302 [2714113] Environ Res. 1989 Jun;49(1):7-19 [2721479] Cytometry. 1989 Jul;10(4):433-41 [2788566] J Allergy Clin Immunol. 1988 Oct;82(4):527-34 [3170998] J Allergy Clin Immunol. 1986 Apr;77(4):616-23 [2420853] J Allergy Clin Immunol. 1976 Jul;58(1 PT. 2):229-40 [783235] Br Med J. 1976 Apr 17;1(6015):936-8 [131592] J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):221-34 [7441082] J Reticuloendothel Soc. 1980 Dec;28(Suppl):61s-71s [6777492] Annu Rev Public Health. 1983;4:203-21 [6860438] J Allergy Clin Immunol. 1983 Dec;72(6):714-9 [6643876] Toxicology. 1990 Jan-Feb;60(1-2):15-25 [2315937] Scand J Work Environ Health. 1990 Apr;16(2):121-8 [2353195] Regul Toxicol Pharmacol. 1989 Feb;9(1):56-80 [2667038] J Allergy Clin Immunol. 1989 Oct;84(4 Pt 1):507-14 [2794294] Clin Immunol Immunopathol. 1989 Jul;52(1):3-9 [2785889] Arch Environ Health. 1990 Jul-Aug;45(4):217-23 [2400243] J Allergy Clin Immunol. 1990 Aug;86(2):177-81 [2384647] Biol Psychol. 1989 Feb;28(1):25-39 [2675991] Occup Med. 1987 Oct-Dec;2(4):669-81 [3313763] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in rats. AN - 72720349; 1666927 AB - THC is the major psychoactive constituent of marijuana and is known to produce psychopharmacological effects in humans. These studies were designed to determine whether acute or chronic exposure to marijuana smoke or THC produces in vitro or in vivo neurochemical alterations in rat or monkey brain. For the in vitro study, THC was added (1-100 nM) to membranes prepared from different regions of the rat brain and muscarinic cholinergic (MCh) receptor binding was measured. For the acute in vivo study, rats were injected IP with vehicle, 1, 3, 10, or 30 mg THC/kg and sacrificed 2 h later. For the chronic study, rats were gavaged with vehicle or 10 or 20 mg THC/kg daily, 5 days/week for 90 days and sacrificed either 24 h or 2 months later. Rhesus monkeys were exposed to the smoke of a single 2.6% THC cigarette once a day, 2 or 7 days a week for 1 year. Approximately 7 months after the last exposure, animals were sacrificed by overdose with pentobarbital for neurochemical analyses. In vitro exposure to THC produced a dose-dependent inhibition of MCh receptor binding in several brain areas. This inhibition of MCh receptor binding, however, was also observed with two other nonpsychoactive derivatives of marijuana, cannabidiol and cannabinol. In the rat in vivo study, we found no significant changes in MCh or other neurotransmitter receptor binding in hippocampus, frontal cortex or caudate nucleus after acute or chronic exposure to THC. In the monkey brain, we found no alterations in the concentration of neurotransmitters in caudate nucleus, frontal cortex, hypothalamus or brain stem.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Pharmacology, biochemistry, and behavior AU - Ali, S F AU - Newport, G D AU - Scallet, A C AU - Paule, M G AU - Bailey, J R AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 677 EP - 682 VL - 40 IS - 3 SN - 0091-3057, 0091-3057 KW - Biogenic Amines KW - 0 KW - Nerve Tissue Proteins KW - Receptors, Cholinergic KW - Cannabidiol KW - 19GBJ60SN5 KW - Serotonin KW - 333DO1RDJY KW - Dronabinol KW - 7J8897W37S KW - Cannabinol KW - 7UYP6MC9GH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Cannabinol -- toxicity KW - Cerebral Cortex -- drug effects KW - Cannabidiol -- pharmacology KW - Caudate Nucleus -- metabolism KW - Cerebral Cortex -- metabolism KW - Frontal Lobe -- drug effects KW - Hippocampus -- metabolism KW - Caudate Nucleus -- drug effects KW - Dopamine -- metabolism KW - Nerve Tissue Proteins -- biosynthesis KW - Hippocampus -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Biogenic Amines -- metabolism KW - Receptors, Cholinergic -- drug effects KW - Frontal Lobe -- metabolism KW - Macaca mulatta KW - Serotonin -- metabolism KW - Time Factors KW - Male KW - Brain Chemistry -- drug effects KW - Dronabinol -- blood KW - Dronabinol -- toxicity KW - Marijuana Smoking -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72720349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Chronic+marijuana+smoke+exposure+in+the+rhesus+monkey.+IV%3A+Neurochemical+effects+and+comparison+to+acute+and+chronic+exposure+to+delta-9-tetrahydrocannabinol+%28THC%29+in+rats.&rft.au=Ali%2C+S+F%3BNewport%2C+G+D%3BScallet%2C+A+C%3BPaule%2C+M+G%3BBailey%2C+J+R%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1991-11-01&rft.volume=40&rft.issue=3&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-14 N1 - Date created - 1992-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals. AN - 72716102; 1666926 AB - Several laboratories have reported that chronic exposure to delta-9-tetrahydrocannabinol (THC) or marijuana extracts persistently altered the structure and function of the rat hippocampus, a paleocortical brain region involved with learning and memory processes in both rats and humans. Certain choices must be made in designing experiments to evaluate cannabis neurotoxicity, such as dose, route of administration, duration of exposure, age at onset of exposure, species of subjects, whether or how long to allow withdrawal, and which endpoints or biomarkers of neurotoxicity to measure. A review of the literature suggests that both age during exposure and duration of exposure may be critical determinants of neurotoxicity. Cannabinoid administration for at least three months (8-10% of a rat's lifespan) was required to produce neurotoxic effects in peripubertal rodents, which would be comparable to about three years exposure in rhesus monkeys and seven to ten years in humans. Studies of monkeys after up to 12 months of daily exposure have not consistently reported neurotoxicity, and the results of longer exposures have not yet been studied. JF - Pharmacology, biochemistry, and behavior AU - Scallet, A C AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 671 EP - 676 VL - 40 IS - 3 SN - 0091-3057, 0091-3057 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Animals KW - Dronabinol -- toxicity KW - Cannabis KW - Nervous System Diseases -- physiopathology KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72716102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Neurotoxicology+of+cannabis+and+THC%3A+a+review+of+chronic+exposure+studies+in+animals.&rft.au=Scallet%2C+A+C&rft.aulast=Scallet&rft.aufirst=A&rft.date=1991-11-01&rft.volume=40&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-14 N1 - Date created - 1992-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The importance of employment status in occupational cohort mortality studies. AN - 72657974; 1790193 AB - Person-years at risk in occupational cohort mortality studies may be defined as "active" (when a person is working) or "inactive" (after a person has left employment at the plant under study). To investigate the effects of employment status (active/inactive) both across studies and within them, we have analyzed ten large cohort studies conducted by the National Institute for Occupational Safety and Health in which no occupational risk had been observed. These ten data sets included 89,376 workers, 1,984,505 person-years, and 18,840 deaths. In these ten studies, the SMR for all causes was positively correlated with the percentage of inactive person-years in the study (r = 0.57, p = 0.08). Considering only inactive person-years, the all-causes SMR was 1.12 (approximately 1.25 before age 65, dropping to 1.00 after age 65). Stratification of inactive person-years by time-since-last-employment showed markedly increased mortality during the first year following employment. The all-causes SMR during active person-years was 0.40 and was fairly constant across age categories. With active and inactive person-years combined, a strong negative trend in SMRs with duration of employment was observed for all causes and for heart disease. These trends were not apparent when person-years were stratified by employment status. These results indicate that investigators should evaluate the effects of employment status when comparing SMRs between multiple cohorts or when interpreting trends in rate ratios within cohorts. JF - Epidemiology (Cambridge, Mass.) AU - Steenland, K AU - Stayner, L AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratory, Cincinnati, OH 45226-1998. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 418 EP - 423 VL - 2 IS - 6 SN - 1044-3983, 1044-3983 KW - Index Medicus KW - Odds Ratio KW - Life Tables KW - Coronary Disease -- mortality KW - Neoplasms -- mortality KW - Risk Factors KW - Humans KW - Cohort Studies KW - Employment KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72657974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=The+importance+of+employment+status+in+occupational+cohort+mortality+studies.&rft.au=Steenland%2C+K%3BStayner%2C+L&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-11-01&rft.volume=2&rft.issue=6&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-31 N1 - Date created - 1992-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selecting exposure parameters in developmental neurotoxicity assessments. AN - 72623744; 1779944 AB - Numerous factors must be considered in selecting exposure parameters for developmental neurotoxicity investigations. Whether employing a single dose during pregnancy, or continuous exposure from prepregnancy through early postnatal developmental periods, the following primary factors should be addressed: 1) Purpose of the study; 2) pharmacokinetics/pharmacodynamics; 3) biotransformation; 4) genotypic variables; 5) limiting factors, including the availability of test compounds for evaluation; and, 6) several general, miscellaneous factors. Whether a single, large dose of an exogenous agent is more toxic to the developing nervous system than a series of smaller doses depends upon the interaction of the physicochemical, pharmacokinetic, and pharmacodynamic properties of the agent with the genotypic features of the test organism. JF - Neurotoxicology and teratology AU - Nelson, B K AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226. PY - 1991 SP - 569 EP - 573 VL - 13 IS - 6 SN - 0892-0362, 0892-0362 KW - Neurotoxins KW - 0 KW - Teratogens KW - Index Medicus KW - Animals KW - Biotransformation KW - Research Design KW - Female KW - Pregnancy KW - Teratogens -- metabolism KW - Neurotoxins -- metabolism KW - Neurotoxins -- pharmacokinetics KW - Teratogens -- pharmacokinetics KW - Aging -- drug effects KW - Nervous System -- drug effects KW - Nervous System -- embryology KW - Teratogens -- toxicity KW - Nervous System -- growth & development KW - Neurotoxins -- toxicity KW - Embryonic and Fetal Development -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72623744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Selecting+exposure+parameters+in+developmental+neurotoxicity+assessments.&rft.au=Nelson%2C+B+K&rft.aulast=Nelson&rft.aufirst=B&rft.date=1991-11-01&rft.volume=13&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-09 N1 - Date created - 1992-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of high doses of morphine on Con-A induced lymphokine production in vitro. AN - 72622773; 1663496 AB - Morphine, a potent analgesic drug as well as the active metabolite derived from heroin, has been reported to affect a variety of immune functions. In vivo administration of high doses of morphine to animals has been shown to inhibit natural killer (NK) cell activity in the rat (Shavit et al., 1984) and splenic T cell mitogenic response in the mouse (Bryant et al., 1988). We report here on the effect of morphine sulfate (MS) (0.2-1.6 mM) on Concanavalin-A (Con-A) stimulated lymphokine production by mouse splenocytes in vitro. Twenty-four hour incubation of mouse splenocytes with MS, removal of the drug and activation with Con-A resulted in a significant (linear regression, P less than 0.001) dose-related inhibition of lymphokine production (IC50 = 0.8 mM) as measured by bioassay for interleukin-2 (IL-2)/interleukin-4 (IL-4). The inhibitory effect of MS on lymphokine production was not blocked by opiate antagonists nor was the inhibitory effect mimicked by equivalent concentrations of mu, delta or epsilon receptor-specific opiate agonists. Exposure to the concentrations of MS used did not reduce viability of mouse splenocytes as determined by Trypan Blue exclusion. Morphine did not inhibit protein synthesis or adenylate cyclase activity in a T cell clone under identical conditions, indicating that MS, in this concentration range, does not simply interfere with all cell functions in a nonspecific manner. These results suggest that (1) morphine directly inhibits splenocyte function, (2) the inhibitory effect is not mediated through classical opiate receptors, and (3) the inhibitory effect is not due to toxicity. JF - Immunopharmacology AU - Jessop, J J AU - Taplits, M S AD - U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892. PY - 1991 SP - 175 EP - 184 VL - 22 IS - 3 SN - 0162-3109, 0162-3109 KW - Lymphokines KW - 0 KW - Receptors, Opioid KW - Concanavalin A KW - 11028-71-0 KW - Naloxone KW - 36B82AMQ7N KW - Morphine KW - 76I7G6D29C KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Protein Biosynthesis KW - Naloxone -- pharmacology KW - Cyclic AMP -- biosynthesis KW - Animals KW - T-Lymphocytes -- metabolism KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - T-Lymphocytes -- drug effects KW - Female KW - Receptors, Opioid -- physiology KW - Lymphokines -- biosynthesis KW - Morphine -- administration & dosage KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72622773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology&rft.atitle=Effect+of+high+doses+of+morphine+on+Con-A+induced+lymphokine+production+in+vitro.&rft.au=Jessop%2C+J+J%3BTaplits%2C+M+S&rft.aulast=Jessop&rft.aufirst=J&rft.date=1991-11-01&rft.volume=22&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology&rft.issn=01623109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-04 N1 - Date created - 1992-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phenytoin teratogenicity and midgestational pharmacokinetics in mice. AN - 72610504; 1771592 AB - Mice of the A/J and C57BL/6J (C57) strains were dosed with phenytoin (PHT) every 48 hr throughout pregnancy by gastric intubation to test the hypothesis that maternal plasma PHT concentration may be the significant factor in determining PHT reproductive and developmental toxicity. Serial serum samples were obtained from each mouse from gestation day (GD) 10-GD 12 for determination of individual dam PHT pharmacokinetics. Maximum PHT concentration and PHT AUC (area under-the-time-concentration curve) were regressed to laparotomy and fetal evaluation endpoints to determine whether significant association existed. Although serum PHT concentrations exceeded levels associated with teratogenicity (greater than 10 micrograms/ml), few major malformations were induced in either strain. However, in the A/J strain, there was a significant increased incidence of hydrocephaly and open eyelid. Regression of pharmacokinetic parameters with embryo and maternal endpoints indicated significant associations between gestational weight gain and maximum concentration measured (Cmax) or AUC in both strains. This association was also found for fetal weight in the C57 strain. In the A/J strain, the induction of decreased ossification of the sternebrae was also associated with maternal PHT concentration; however, linear regression of hydrocephaly and open eyelid to PHT concentration was not statistically significant. These results suggest that maternal plasma PHT concentration may be a quantifiable determinant of certain aspects of PHT developmental toxicity in the mouse. JF - Teratology AU - Roberts, L G AU - Laborde, J B AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 497 EP - 505 VL - 44 IS - 5 SN - 0040-3709, 0040-3709 KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Half-Life KW - Dose-Response Relationship, Drug KW - Gestational Age KW - Mice KW - Fetal Death -- chemically induced KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Phenytoin -- pharmacokinetics KW - Phenytoin -- toxicity KW - Phenytoin -- blood KW - Abnormalities, Drug-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72610504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Phenytoin+teratogenicity+and+midgestational+pharmacokinetics+in+mice.&rft.au=Roberts%2C+L+G%3BLaborde%2C+J+B%3BSlikker%2C+W&rft.aulast=Roberts&rft.aufirst=L&rft.date=1991-11-01&rft.volume=44&rft.issue=5&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypoglycemia associated hospitalizations in a population with a high prevalence of non-insulin-dependent diabetes mellitus. AN - 72578501; 1756685 AB - In order to evaluate the rates, causes, and clinical features of hospitalizations associated with hypoglycemia in a population with a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM), a retrospective analysis of medical records was conducted in a multi-hospital primary care system on the Navajo Indian Reservation. During an estimated 26,125 person-years of observation among diabetic patients, there were 126 hypoglycemia-associated admissions related to diabetes among 109 diabetic patients, yielding a hospitalization rate of 4.7 per 1000 person-years (95% CI 4.1-5.7). Using estimates of drug utilization based on a defined daily dose, hospitalization rates were 5.8 per 1000 PY (95% CI 4.4-7.6) for chlorpropamide, 16.0 per 1000 PY (95% CI 9.5-26.9) for glyburide, and 9.1 per 1000 PY (95% CI 6.9-11.9) for insulin. After stratification by age, the relative risk for hypoglycemia-associated hospitalization among patients prescribed glyburide compared to those prescribed chlorpropamide was 2.8 (95% CI 1.6-4.9). Hypoglycemia-associated hospitalizations were relatively common among patients with NIDDM, particularly among those treated with glyburide. JF - Diabetes research and clinical practice AU - Sugarman, J R AD - Indian Health Service Epidemiology Program, Seattle, Washington. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 139 EP - 147 VL - 14 IS - 2 SN - 0168-8227, 0168-8227 KW - Insulin KW - 0 KW - Glyburide KW - SX6K58TVWC KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - New Mexico -- epidemiology KW - Hospitalization KW - Arizona -- epidemiology KW - Humans KW - Utah -- epidemiology KW - Retrospective Studies KW - Prevalence KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Chlorpropamide -- adverse effects KW - Indians, North American KW - Glyburide -- adverse effects KW - Hypoglycemia -- mortality KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Hypoglycemia -- epidemiology KW - Hypoglycemia -- chemically induced KW - Insulin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72578501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+research+and+clinical+practice&rft.atitle=Hypoglycemia+associated+hospitalizations+in+a+population+with+a+high+prevalence+of+non-insulin-dependent+diabetes+mellitus.&rft.au=Sugarman%2C+J+R&rft.aulast=Sugarman&rft.aufirst=J&rft.date=1991-11-01&rft.volume=14&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Diabetes+research+and+clinical+practice&rft.issn=01688227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Separation and determination of diesel contaminants in various fish products by capillary gas chromatography. AN - 72568925; 1757424 AB - A semiquantitative capillary column gas chromatographic method is described for the determination of diesel fuel contamination in various canned seafood products. The diesel contaminants are separated from the fish sample by steam distillation, with little carry-over of interfering intrinsic materials such as fish oils. The diesel fuel is extracted from the condensate with n-hexane, and the extract is analyzed on an SPB-1 fused silica capillary column. The efficiency of recovery of diesel fuel added to canned seafood at levels of 40-400 ppt ranged from 72 to 102%. With the additional step of concentrating the hexane extract, the sensitivity of this procedure may be increased at least 10-fold. This procedure can detect the differences among diesel fuel grades No. 1, 2, and 5, and variations within diesel grade No. 2, and thus may be useful in determining the type of petroleum contaminants present in various canned fish products. JF - Journal - Association of Official Analytical Chemists AU - Newton, J M AU - Rothman, B S AU - Walker, F A AD - Food and Drug Administration, San Francisco, CA 94102. PY - 1991 SP - 986 EP - 990 VL - 74 IS - 6 SN - 0004-5756, 0004-5756 KW - Petroleum KW - 0 KW - Index Medicus KW - Petroleum -- analysis KW - Food Contamination KW - Fish Products -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72568925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Separation+and+determination+of+diesel+contaminants+in+various+fish+products+by+capillary+gas+chromatography.&rft.au=Newton%2C+J+M%3BRothman%2C+B+S%3BWalker%2C+F+A&rft.aulast=Newton&rft.aufirst=J&rft.date=1991-11-01&rft.volume=74&rft.issue=6&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of organochlorine pesticide residues using simultaneous injection of two capillary columns with electron capture and electrolytic conductivity detectors. AN - 72568895; 1757423 AB - A system has been developed that will allow low level screening of 31 organochlorine pesticide residues using simultaneous injection on 2 dissimilar capillary columns. An electron capture detector was attached to a DB-1701 column, and an electrolytic conductivity detector in the halogen mode was attached to a DB-5 column. Chlorinated pesticide amounts ranging from 0.05 ng for gamma-BHC to 1.5 ng for decamethrin can easily be quantitated and confirmed. The system can be used in either the column programmed mode or the isothermal column mode. Good reproducibility was obtained for injections in both modes. This system can easily be retrofitted to any gas chromatograph using on column or split/splitless injectors. JF - Journal - Association of Official Analytical Chemists AU - Hopper, M L AD - Food and Drug Administration, Total Diet Research Center, Kansas City, MO 64106. PY - 1991 SP - 974 EP - 981 VL - 74 IS - 6 SN - 0004-5756, 0004-5756 KW - Hydrocarbons, Chlorinated KW - 0 KW - Insecticides KW - Pesticide Residues KW - Index Medicus KW - Temperature KW - Chromatography, Gas -- instrumentation KW - Pesticide Residues -- analysis KW - Insecticides -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72568895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Analysis+of+organochlorine+pesticide+residues+using+simultaneous+injection+of+two+capillary+columns+with+electron+capture+and+electrolytic+conductivity+detectors.&rft.au=Hopper%2C+M+L&rft.aulast=Hopper&rft.aufirst=M&rft.date=1991-11-01&rft.volume=74&rft.issue=6&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bacillus stearothermophilus disk assay for determining ampicillin residues in fish muscle. AN - 72565332; 1757413 AB - The Bacillus stearothermophilus disk assay for penicillin in milk (AOAC official method) was adapted for the determination of ampicillin in fish muscle. The method was evaluated in 2 species of cultured fish: channel catfish and striped bass. Recoveries of ampicillin ranged from 99 to 104% when muscle specimens from both species were spiked at concentrations of 0.025-1.00 micrograms/g. The lower limit of determination (LOD) was 0.025 micrograms/g. The assay was applied to monitor the elimination of ampicillin from the muscle of striped bass after intravascular administration (dosage of 10 mg/kg body weight). The mean concentrations in the muscle declined from 1.160 micrograms/g at 2 h to 0.063 micrograms/g at 18 h. The half-life of ampicillin in the muscle was 3.6 h. Ampicillin concentrations were below LOD at 24 h. No inhibitory activity was observed in the muscle of control fish. JF - Journal - Association of Official Analytical Chemists AU - Plakas, S M AU - DePaola, A AU - Moxey, M B AD - Food and Drug Administration, Fishery Research Branch, Dauphin Island, AL 36528. PY - 1991 SP - 910 EP - 912 VL - 74 IS - 6 SN - 0004-5756, 0004-5756 KW - Ampicillin KW - 7C782967RD KW - Index Medicus KW - Animals KW - Muscles -- chemistry KW - Geobacillus stearothermophilus -- growth & development KW - Ictaluridae KW - Drug Residues -- analysis KW - Biological Assay KW - Ampicillin -- analysis KW - Geobacillus stearothermophilus -- drug effects KW - Ampicillin -- pharmacology KW - Bass KW - Ampicillin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72565332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Bacillus+stearothermophilus+disk+assay+for+determining+ampicillin+residues+in+fish+muscle.&rft.au=Plakas%2C+S+M%3BDePaola%2C+A%3BMoxey%2C+M+B&rft.aulast=Plakas&rft.aufirst=S&rft.date=1991-11-01&rft.volume=74&rft.issue=6&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-06 N1 - Date created - 1992-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Megestrol acetate in AIDS-related cachexia. AN - 72543995; 1746586 JF - American journal of hospital pharmacy AU - Mahayni, H AU - Minor, J R AD - Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, MD 20852. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 2479 EP - 2480 VL - 48 IS - 11 SN - 0002-9289, 0002-9289 KW - Megestrol KW - EA6LD1M70M KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Megestrol -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- complications KW - Cachexia -- drug therapy KW - Megestrol -- adverse effects KW - Megestrol -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72543995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hospital+pharmacy&rft.atitle=Megestrol+acetate+in+AIDS-related+cachexia.&rft.au=Mahayni%2C+H%3BMinor%2C+J+R&rft.aulast=Mahayni&rft.aufirst=H&rft.date=1991-11-01&rft.volume=48&rft.issue=11&rft.spage=2479&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hospital+pharmacy&rft.issn=00029289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Safety of ethoxyquin in dog foods. AN - 72458542; 1941216 JF - The Journal of nutrition AU - Dzanis, D A AD - Animal Feed Safety Branch, Food and Drug Administration, Rockville, MD 20857. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - S163 EP - S164 VL - 121 IS - 11 Suppl SN - 0022-3166, 0022-3166 KW - Ethoxyquin KW - 9T1410R4OR KW - Index Medicus KW - Animals KW - Dogs KW - Animal Feed -- adverse effects KW - Dog Diseases -- chemically induced KW - Ethoxyquin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72458542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Safety+of+ethoxyquin+in+dog+foods.&rft.au=Dzanis%2C+D+A&rft.aulast=Dzanis&rft.aufirst=D&rft.date=1991-11-01&rft.volume=121&rft.issue=11+Suppl&rft.spage=S163&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-25 N1 - Date created - 1991-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific binding of host cell proteins to the 3'-terminal stem-loop structure of rubella virus negative-strand RNA. AN - 72143390; 1920622 AB - At the 5' end of the rubella virus genomic RNA, there are sequences that can form a potentially stable stem-loop (SL) structure. The complementary negative-strand equivalent of the 5'-end SL structure of positive-strand rubella virus RNA [5' (+) SL structure] is thought to serve as a promoter for the initiation of positive-strand synthesis. We screened the negative-strand equivalent of the 5' (+) SL structure (64 nucleotides) and the adjacent region of the negative-strand RNA for their ability to bind to host cell proteins. Specific binding to the 64-nucleotide-long potential SL structure of three cytosolic proteins with relative molecular masses of 97, 79, and 56 kDa was observed by UV-induced covalent cross-linking. There was a significant increase in the binding of the 97-kDa protein from cells upon infection with rubella virus. Altering the SL structure by deleting sequences in either one of the two potential loops abolished the binding interaction. The 56-kDa protein also appeared to bind specifically to an SL derived from the 3' end of positive-strand RNA. The 3'-terminal structure of rubella virus negative-strand RNA shared the same protein-binding activity with similar structures in alphaviruses, such as Sindbis virus and eastern equine encephalitis virus. A possible role for the host proteins in the replication of rubella virus and alphaviruses is discussed. JF - Journal of virology AU - Nakhasi, H L AU - Cao, X Q AU - Rouault, T A AU - Liu, T Y AD - Division of Biochemistry and Biophysics, CBER, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 5961 EP - 5967 VL - 65 IS - 11 SN - 0022-538X, 0022-538X KW - Oligodeoxyribonucleotides KW - 0 KW - RNA, Viral KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Base Sequence KW - Models, Structural KW - Sindbis Virus -- genetics KW - Sequence Homology, Nucleic Acid KW - Molecular Sequence Data KW - Vero Cells KW - Protein Binding KW - Nucleic Acid Conformation KW - Molecular Weight KW - Transcription, Genetic KW - Rubella virus -- genetics KW - RNA, Viral -- isolation & purification KW - RNA, Viral -- genetics KW - RNA, Viral -- metabolism KW - Rubella virus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72143390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Specific+binding+of+host+cell+proteins+to+the+3%27-terminal+stem-loop+structure+of+rubella+virus+negative-strand+RNA.&rft.au=Nakhasi%2C+H+L%3BCao%2C+X+Q%3BRouault%2C+T+A%3BLiu%2C+T+Y&rft.aulast=Nakhasi&rft.aufirst=H&rft.date=1991-11-01&rft.volume=65&rft.issue=11&rft.spage=5961&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-14 N1 - Date created - 1991-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 1987 Sep;68 ( Pt 9):2347-57 [3655744] Proc Natl Acad Sci U S A. 1987 Jul;84(14):4811-5 [2440030] Nucleic Acids Res. 1987 Nov 11;15(21):8783-98 [3684574] J Gen Virol. 1988 Mar;69 ( Pt 3):603-12 [3351478] Gene. 1988;62(1):85-99 [2836271] Science. 1988 Sep 2;241(4870):1207-10 [3413484] Annu Rev Microbiol. 1988;42:657-83 [3060004] Science. 1989 Apr 21;244(4902):357-9 [2711187] Genes Dev. 1989 Apr;3(4):431-7 [2470643] Nucleic Acids Res. 1989 Jun 12;17(11):4393-4 [2740235] Gene. 1989 Oct 30;82(2):343-9 [2583526] J Virol. 1990 Apr;64(4):1465-76 [2319643] J Virol. 1990 Apr;64(4):1639-47 [2319648] Virology. 1990 Jul;177(1):225-38 [2353453] J Virol. 1990 Sep;64(9):4162-8 [2384916] Cell. 1990 Oct 19;63(2):369-80 [2170027] New Biol. 1990 Mar;2(3):255-64 [2279029] Science. 1991 Mar 29;251(5001):1597-600 [2011739] Nucleic Acids Res. 1981 Jan 10;9(1):133-48 [6163133] Arch Virol. 1982;72(1-2):47-54 [7103739] Virology. 1983 Apr 15;126(1):194-203 [6845655] J Virol. 1984 Feb;49(2):403-8 [6694262] Cell. 1986 Jan 17;44(1):137-45 [3753584] Virology. 1986 Oct 15;154(1):228-32 [3755848] J Biol Chem. 1986 Dec 15;261(35):16616-21 [3023358] Nucleic Acids Res. 1987 Apr 10;15(7):3041-57 [3562245] J Virol. 1988 Jan;62(1):47-53 [3334750] N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Child Health USA '91. AN - 62943969; ED345437 AB - This booklet summarizes recent information on the current health status and service needs of America's children. The booklet is intended to present sentinel health measures in a readily accessible and readable format to illustrate what has been accomplished for children and to identify what challenges remain. The booklet's four sections cover: general population data (population of children, children in poverty, family composition, working mothers, child care, and school dropouts); data for selected health status measures such as mortality, hospitalization, child abuse, and teenage sexuality, organized by developmental stages (infancy, childhood, and adolescence); information on health services utilization, such as health care financing, physician visits, hospital utilization by income, prenatal care, and immunization; and State-specific data on infant health, including mortality and prenatal care, low birth weight, and births to women under 18 years of age. (Approximately 40 references) (JDD) Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 113 VL - HRS-M-CH-91-1 KW - Service Utilization KW - ERIC, Resources in Education (RIE) KW - Demography KW - Health Services KW - Health Needs KW - Individual Characteristics KW - Child Health KW - Children KW - Physical Health KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62943969?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Photographs will not reproduce. N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Characterization of Iodine Derivatives of Aflatoxin B1 and G1 by Thermospray Mass Spectrometry AN - 1093460066; 17185288 AB - Thermospray mass spectrometry (TSMS) was used to identify the derivatives formed when iodine is reacted with aflatoxins B1 and G1 at approximately 70A?C to enhance fluorescence. It was found that stable derivatives were formed by addition of an iodine atom and a methoxy group across the double bond located on the furan ring of the aflatoxin B1 and G1 molecules. TSMS and TSMS/MS daughter spectra of the reaction products of aflatoxin B1 and G1 with iodine provide evidence of the addition of each moiety to produce the iodoa-'methoxy derivative. The addition of an iodine atom to one carbon and a methoxy group to the other carbon of the furan ring provided molecular weights of 470 and 486 for the products of aflatoxin B1 and G1, respectively. JF - Journal of Analytical Toxicology AU - Holcomb, Manuel AU - Korfmacher, Walter A AU - Thompson, Harold C AD - Department of Health and Human Services, Public Health Services, Food and Drug Administration, National Center for Toxicological Research, Office of Research Services, Division of Chemistry & Division of Biochemical Toxicology Jefferson, Arkansas 72079 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 289 EP - 292 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 15 IS - 6 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Aflatoxin B1 KW - Carbon KW - Fluorescence KW - Molecular weight KW - Iodine KW - Furans KW - Mass spectroscopy KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093460066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Characterization+of+Iodine+Derivatives+of+Aflatoxin+B1+and+G1+by+Thermospray+Mass+Spectrometry&rft.au=Holcomb%2C+Manuel%3BKorfmacher%2C+Walter+A%3BThompson%2C+Harold+C&rft.aulast=Holcomb&rft.aufirst=Manuel&rft.date=1991-11-01&rft.volume=15&rft.issue=6&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/1991/00000015/00000006/art00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Aflatoxin B1; Fluorescence; Carbon; Molecular weight; Iodine; Furans; Mass spectroscopy ER - TY - JOUR T1 - Methomyl in the Blood of a Pilot Who Crashed during Aerial Spraying AN - 1093455310; 17185298 AB - An aerial-spray pilot died when his aircraft crashed while he was spraying methomyl. We measured the pesticide in his blood by gas chromatography with flame photometric detection and confirmed the results by mass spectrometry with direct liquid injection through a liquid chromatography interface. The whole blood methomyl concentration was 570 ng/mL. JF - Journal of Analytical Toxicology AU - Driskell, William J AU - Groce, Don F AU - Hill, Robert H AU - Birky, Merritt M AD - Toxicology Branch, Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, 1600 Clifton Road, Public Health Service, U.S. Department of Health and Human Services, Atla Y1 - 1991/11// PY - 1991 DA - Nov 1991 SP - 339 EP - 340 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 15 IS - 6 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Aircraft KW - Blood KW - Blood levels KW - Gas chromatography KW - Liquid chromatography KW - Mass spectroscopy KW - Pesticides KW - Spraying KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093455310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Methomyl+in+the+Blood+of+a+Pilot+Who+Crashed+during+Aerial+Spraying&rft.au=Driskell%2C+William+J%3BGroce%2C+Don+F%3BHill%2C+Robert+H%3BBirky%2C+Merritt+M&rft.aulast=Driskell&rft.aufirst=William&rft.date=1991-11-01&rft.volume=15&rft.issue=6&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/1991/00000015/00000006/art00011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Blood; Aircraft; Liquid chromatography; Gas chromatography; Pesticides; Spraying; Mass spectroscopy; Blood levels ER - TY - JOUR T1 - Hearing loss in the chinchilla from impact and continuous noise exposure. AN - 85148699; pmid-1669963 AB - The relative hazard posed to the peripheral auditory system by impact/impulse and continuous noise of the same power spectrum was determined. Impact noise was generated by striking a nail with a hammer and was digitally recorded. The acoustical power spectrum of the impact was determined and pink noise was filtered to produce a continuous noise stimulus with the same acoustic power spectrum. Pre-exposure auditory evoked response (AER) thresholds were obtained at 1, 2, 4, and 8 kHz on 16 adult chinchillas. The pool of animals was divided into two equal groups based upon pre-exposure AER thresholds. One group was exposed to impact noise and the other group to the filtered pink noise. Exposures were 4 h/day for 5 days. Thirty days following the exposure, auditory evoked response thresholds were remeasured. Changes in auditory sensitivity were determined by subtracting the pre-exposure thresholds from the post-exposure thresholds. Hearing threshold shifts of the impact noise group were significantly greater (p less than 0.0001) than the hearing threshold shifts of the continuous noise group. These data indicate a need to more closely examine the parameters and effects of impact noise. There may be a need to develop expanded damage-risk criteria for occupational exposure to impulse/impact noise. JF - The Journal of the Acoustical Society of America AU - Dunn, D E AU - Davis, R R AU - Merry, C J AU - Franks, John Richard AD - U.S. Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.; Bioacoustics and Occupational Vibration Section, Physical Agents Effects Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.; Department of Speech and Hearing Science, College of Social and Behavioral Sciences, Colleges of the Arts and Sciences, Ohio State University PY - 1991 SP - 1979 EP - 1985 VL - 90 IS - 4 Pt 1 SN - 0001-4966, 0001-4966 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85148699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Hearing+loss+in+the+chinchilla+from+impact+and+continuous+noise+exposure.&rft.au=Dunn%2C+D+E%3BDavis%2C+R+R%3BMerry%2C+C+J%3BFranks%2C+John+Richard&rft.aulast=Dunn&rft.aufirst=D&rft.date=1991-10-01&rft.volume=90&rft.issue=4+Pt+1&rft.spage=1979&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Characterization of the mycotoxin fumonisin B1: comparison of thermospray, fast-atom bombardment and electrospray mass spectrometry. AN - 72760020; 1841646 AB - The utility of thermospray mass spectrometry (TSMS), fast-atom bombardment mass spectrometry (FABMS), and electrospray mass spectrometry (ESMS) for the analysis of Fumonisin B1 is investigated. In addition, the analysis of two different standards of Fumonisin B1 as well as an inoculated corn culture extract that contained Fumonisin B1 is reported. The results of these efforts show that ESMS, as well as FABMS and a combination of FAB and tandem mass spectrometry (FABMS/MS), provide useful data for the characterization of Fumonisin B1. The detection limit was 50 pg for Fumonisin B1 when analyzed by full scan FABMS, and 5 pg when analyzed by single-reaction monitoring FABMS/MS. JF - Rapid communications in mass spectrometry : RCM AU - Korfmacher, W A AU - Chiarelli, M P AU - Lay, J O AU - Bloom, J AU - Holcomb, M AU - McManus, K T AD - US FDA, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 463 EP - 468 VL - 5 IS - 10 SN - 0951-4198, 0951-4198 KW - Fumonisins KW - 0 KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Mass Spectrometry KW - Zea mays -- chemistry KW - Electrochemistry KW - Spectrometry, Mass, Fast Atom Bombardment KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72760020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Characterization+of+the+mycotoxin+fumonisin+B1%3A+comparison+of+thermospray%2C+fast-atom+bombardment+and+electrospray+mass+spectrometry.&rft.au=Korfmacher%2C+W+A%3BChiarelli%2C+M+P%3BLay%2C+J+O%3BBloom%2C+J%3BHolcomb%2C+M%3BMcManus%2C+K+T&rft.aulast=Korfmacher&rft.aufirst=W&rft.date=1991-10-01&rft.volume=5&rft.issue=10&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-23 N1 - Date created - 1992-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of the Mantel-Haenszel chi 2 overestimates precision in studies with sparse data. AN - 72566813; 1753307 AB - Probability values or "test-based" confidence limits computed on the basis of the Mantel-Haenszel chi 2 statistic may be invalid if minimum cell-size requirements are not met. In 30 studies of occupational proportionate mortality published from 1985 through 1987, the Mantel-Haenszel chi 2 was used in potential violation of cell-size requirements in 21 studies. Sixteen (76%) studies included at least one value that, when compared with testing with the Poisson distribution, was erroneously reported as statistically significant at the 0.05 level. We conclude that by using the Mantel-Haenszel chi 2 with sparse data, some epidemiologists overestimate precision. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - O'Brien, T R AU - Flanders, W D AU - Decoufle, P AD - Centers for Disease Control, Public Health Service, Atlanta, Ga 30333. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 1081 EP - 1083 VL - 33 IS - 10 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - Probability KW - Humans KW - Confidence Intervals KW - Bias (Epidemiology) KW - Data Interpretation, Statistical KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72566813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Use+of+the+Mantel-Haenszel+chi+2+overestimates+precision+in+studies+with+sparse+data.&rft.au=O%27Brien%2C+T+R%3BFlanders%2C+W+D%3BDecoufle%2C+P&rft.aulast=O%27Brien&rft.aufirst=T&rft.date=1991-10-01&rft.volume=33&rft.issue=10&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-29 N1 - Date created - 1992-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biologic basis for a risk assessment model for cleft palate. AN - 72502229; 1742301 AB - A biologic model for palatogenesis is presented, intended as a basis for risk assessment. It comprises a sequence of developmental stages: growth and migration of neural crest cells, downward growth of palatal buds, elevation of palatal shelves, and differentiation of the epithelium followed by shelf fusion. Several events representing these stages and amenable to mathematical translation may be measurable in the form of biomarkers such as DNA and protein synthesis, phospholipid metabolism, and signal transducing systems. Interrupting components of the model will result in cleft palate. Teratogens with known mechanisms of action are compared with the model. The quantitative risk of cleft palate is conceived as a sequence of mathematical probabilities that any stage of the model runs an abnormal course. Stage-specific probabilities are determined by a chemical's potency and dose, and by duration of exposure and gestational age. Species or strain sensitivity may be expressed as quantitative differences in model parameters. Although the model is designed for cleft palate, the risk model may also estimate a multiple response risk to the same exposures. JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association AU - Freni, S C AU - Zapisek, W F AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 338 EP - 346 VL - 28 IS - 4 SN - 1055-6656, 1055-6656 KW - Dentistry KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Cleft Palate -- chemically induced KW - Cleft Palate -- etiology KW - Cleft Palate -- embryology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72502229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Cleft+palate-craniofacial+journal+%3A+official+publication+of+the+American+Cleft+Palate-Craniofacial+Association&rft.atitle=Biologic+basis+for+a+risk+assessment+model+for+cleft+palate.&rft.au=Freni%2C+S+C%3BZapisek%2C+W+F&rft.aulast=Freni&rft.aufirst=S&rft.date=1991-10-01&rft.volume=28&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=The+Cleft+palate-craniofacial+journal+%3A+official+publication+of+the+American+Cleft+Palate-Craniofacial+Association&rft.issn=10556656&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-10 N1 - Date created - 1992-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of a simple weight-loss method for determining the permeation of organic liquids through rubber films. AN - 72485284; 1951056 AB - The standard ASTM method for determining permeation of liquid penetrants through polymeric films (F739-85) was compared with a simple weight-loss method. The weight-loss permeation cell was constructed of off-the-shelf components, a conventional analytical balance was used to measure the weight loss, and a chamber with continuous ventilation was used to hold the cell at constant temperature and evacuate the permeating penetrant. The advantages and limitations of the weight-loss method were illustrated by using data obtained from the permeation of acetonitrile, n-hexane, and methanol through films of four acrylonitrile-butadiene copolymers. The steady-state flux obtained by using the weight-loss method gave results statistically equivalent to the more analytically complex ASTM standard method. The weight-loss method required the experimenter to monitor the weight of the cell and its contents over time to obtain the steady-state flux whereas the ASTM method required the experimenter to chemically analyze for the penetrant concentration in the effluent gas stream as a function of time. The ASTM method required more analytical skill and training and more costly analytical equipment than did the simple weight-loss method. The weight-loss method needs further improvement and validation but shows promise even in its present form. By using the weight-loss method, the potential exists for far more chemical protective clothing users to conduct their own low-cost permeation testing as an initial screening to determine the relative permeation performance of candidate protective clothing materials. The weight-loss method is not meant to replace the standard ASTM method but to supplement it as a screening test. JF - American Industrial Hygiene Association journal AU - Mickelsen, R L AU - Hall, R C AU - Chern, R T AU - Myers, J R AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV 26505. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 445 EP - 447 VL - 52 IS - 10 SN - 0002-8894, 0002-8894 KW - Hazardous Substances KW - 0 KW - Polymers KW - Index Medicus KW - Evaluation Studies as Topic KW - Humans KW - Protective Clothing -- standards KW - Occupational Medicine -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72485284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Evaluation+of+a+simple+weight-loss+method+for+determining+the+permeation+of+organic+liquids+through+rubber+films.&rft.au=Mickelsen%2C+R+L%3BHall%2C+R+C%3BChern%2C+R+T%3BMyers%2C+J+R&rft.aulast=Mickelsen&rft.aufirst=R&rft.date=1991-10-01&rft.volume=52&rft.issue=10&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-19 N1 - Date created - 1991-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse behavioral reactions attributed to triazolam in the Food and Drug Administration's Spontaneous Reporting System. AN - 72159441; 1929688 AB - Reports of adverse behavioral reactions to triazolam, a triazolobenzodiazepine ultra-short-acting hypnotic, were examined in the postmarketing surveillance Spontaneous Reporting System of the Food and Drug Administration. Reports for triazolam of confusion, amnesia, bizarre behavior, agitation, and hallucinations were compared with reports of these reactions for temazepam, another short-acting hypnotic. Analysis of individual case reports from marketing through 1985 for triazolam vs temazepam showed 133 vs two for confusion, 109 vs three for amnesia, 59 vs two for bizarre behavior, 58 vs four for agitation, and 40 vs one for hallucinations. Considering extent of use, reporting rates for triazolam were 22 to 99 times those for temazepam, depending on the reaction. Reactions to triazolam tended to occur at higher doses and in older patients. This and an updated analysis of aggregate reports for the first 7 years of marketing of each drug with reporting rates and adjustment for various factors suggest a higher occurrence of these reactions with triazolam, but selection factors cannot be completely ruled out. When treating insomnia, physicians should emphasize sleep hygiene practices as alternatives to drug therapy; if drug therapy is required, they should prescribe hypnotics at the lowest recommended doses for the shortest clinically necessary durations and discontinue medication use should any adverse reactions occur. JF - Archives of internal medicine AU - Wysowski, D K AU - Barash, D AD - Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Md. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 2003 EP - 2008 VL - 151 IS - 10 SN - 0003-9926, 0003-9926 KW - Triazolam KW - 1HM943223R KW - Temazepam KW - CHB1QD2QSS KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Age Factors KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - United States Food and Drug Administration KW - Temazepam -- adverse effects KW - Product Surveillance, Postmarketing KW - Cognition Disorders -- chemically induced KW - Triazolam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72159441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Adverse+behavioral+reactions+attributed+to+triazolam+in+the+Food+and+Drug+Administration%27s+Spontaneous+Reporting+System.&rft.au=Wysowski%2C+D+K%3BBarash%2C+D&rft.aulast=Wysowski&rft.aufirst=D&rft.date=1991-10-01&rft.volume=151&rft.issue=10&rft.spage=2003&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1992 Jul;152(7):1527-9 [1627034] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of sequences within the murine granulocyte-macrophage colony-stimulating factor mRNA 3'-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cells. AN - 72132807; 1917935 AB - Phorbol esters (TPA) and concanavalin A (ConA) are known to induce granulocyte-macrophage colony-stimulating factor (GM-CSF) production in murine thymoma EL-4 cells by mRNA stabilization. The role of the 3'-untranslated region (3'-UTR) in GM-CSF mRNA stabilization induced by TPA and ConA in EL-4 cells was examined by transfection studies using chloramphenicol acetyltransferase (CAT) constructions. The GM-CSF 3'-UTR contains a 63-nucleotide region at its 3' end with repeating ATTTA motifs which is responsible for mRNA degradation in a variety of cell types (Shaw, G., and Kamen, R. (1986) Cell 46, 659-666). We produced constructs containing most of the GM-CSF 3'-UTR (303 nucleotides, pRSV-CATgm) or the 3'-terminal AT-rich region (116 nucleotides, pRSV-CATau) and measured CAT enzyme activity and CAT mRNA after transient transfection into EL-4 and NIH 3T3 cells. Low levels of CAT activity were seen in both cells with either plasmid compared with levels of CAT activity obtained with pRSV-CAT. TPA treatment caused an approximately 10-fold increase in CAT activity and mRNA in EL-4 cells transfected with pRSV-CATgm. No increases were seen in EL-4 cells transfected with pRSV-CATau or pRSV-CAT. No response to TPA was detected in transfected NIH 3T3 cells, indicating that the response to TPA is relatively cell-specific. There was no increase in CAT activity after ConA treatment in EL-4 or NIH 3T3 cells transfected with any of the constructs suggesting that the GM-CSF 3'-UTR lacks elements that can respond alone to ConA. Nuclear run-on and actinomycin D chase experiments in EL-4 cells showed that TPA induces CAT activity via mRNA stabilization. By linker-substitution mutagenesis we show that TPA inducibility depends on a 60-nucleotide region of the 3'-UTR whose 5' end is located 160 nucleotides upstream of the 5' end of the AU-rich region. JF - The Journal of biological chemistry AU - Iwai, Y AU - Bickel, M AU - Pluznik, D H AU - Cohen, R B AD - Division of Cytokine Biology, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/09/25/ PY - 1991 DA - 1991 Sep 25 SP - 17959 EP - 17965 VL - 266 IS - 27 SN - 0021-9258, 0021-9258 KW - DNA, Neoplasm KW - 0 KW - Mitogens KW - RNA, Messenger KW - RNA, Neoplasm KW - Concanavalin A KW - 11028-71-0 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Transcription, Genetic KW - Mice KW - RNA, Neoplasm -- genetics KW - Chloramphenicol O-Acetyltransferase -- metabolism KW - Plasmids KW - Mutagenesis KW - Base Sequence KW - Transfection KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - DNA, Neoplasm -- genetics KW - Protein Biosynthesis KW - Granulocyte-Macrophage Colony-Stimulating Factor -- genetics KW - Thymoma -- genetics KW - RNA, Messenger -- genetics KW - Thymoma -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72132807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+of+sequences+within+the+murine+granulocyte-macrophage+colony-stimulating+factor+mRNA+3%27-untranslated+region+that+mediate+mRNA+stabilization+induced+by+mitogen+treatment+of+EL-4+thymoma+cells.&rft.au=Iwai%2C+Y%3BBickel%2C+M%3BPluznik%2C+D+H%3BCohen%2C+R+B&rft.aulast=Iwai&rft.aufirst=Y&rft.date=1991-09-25&rft.volume=266&rft.issue=27&rft.spage=17959&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-29 N1 - Date created - 1991-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - HEALTH CARE FINANCING ADMINISTRATION CONSOLIDATION, BALTIMORE, MARYLAND. AN - 36394271; 3286 AB - PURPOSE: Consolidation of the offices and activities of the Health Care Financing Administration (HCFA) in Baltimore, Maryland is proposed. The HCFA, which is a section of the Department of Health and Human Services, currently employs 2,800 persons, who occupy nine buildings in the Woodlawn area of Baltimore County, Maryland. Based on project growth and current operational inefficiencies associated with this diffuse organization, HCFA needs to consolidate operations. As a result, the General Services Administration has been authorized to enter into a lease ownership selection process for approximately 664,100 occupiable square feet for a consolidated HCFA headquarters. A new HCFA site in the general Woodlawn area or in Baltimore City has also been authorized. Four locations are under consideration. One site is located in downtown Baltimore City; the site is bounded by Baltimore Street on the north, Greene Street on the west, Camden to Howard to Conway streets on the south, and Light and St. Paul streets on the east. Two other areas, located in Baltimore County, are adjacent to one another. One is in the Owings Mills area and the other in Woodlawn. The Owings Mills area is bounded by Route 695 to the east, proceeding northward to Route 795 to the Owings Mills Exit and Owings Mills Boulevard, traversing southeast to Lyons Mills Road to McDonogh Road to the northern side of Liberty Road. The Woodlawn area is defined as the area south of Liberty Road to Rolling Road, proceeding to Route 70; the area generally encompasses the zone between the current HCFA site and the Owings Mills location. The No Build alternative assumes that HCFA offices would remain in the present Woodlawn locations. POSITIVE IMPACTS: By centralizing HFCA operations, the new facility would increase the agency's efficiency and effectiveness. Regardless of the location of the facility, office vacancy rates would decline in the immediate area. In general, the area chosen for construction would experience a significant economic boost. NEGATIVE IMPACTS: Some portions of the Owings Mills area would be affected by the potential for subsidence, and both this area and the Woodlawn site could be subject to various forms of minor ground failure in the future. Development of the facility at either of the county sites would result in some degradation of surface water quality, increases in storm water runoff due to removal of vegetation and soil, reduction of groundwater recharge, displacement of wildlife habitat, and some conflicts with local land use patterns. The city site would lie partly within the Chesapeake Bay Critical Area. Both county sites would contain some floodplains. Placement of the facility at one of the county sites would involve more travel miles and vehicle trips than placement of the facility within the city. More land area would be needed for parking facilities at the county sites than at the city site. Any site would lie within a nonattainment area for ozone and particulate matter, and travel to and from the sites would contribute to these and other pollutant loadings. Daytime population increases would amount to 2.5 percent for the city and 20 to 22 percent for the county sites. Office vacancy rates in the areas of the existing decentralized facilities would increase significantly, and retail trade would decrease significantly upon consolidation at a single site. The potential for impacts to historic buildings or districts would be more likely in Owings Mills or downtown Baltimore than in Woodlawn. Utility hookups would be more difficult at the county sites than in the city. JF - EPA number: 910346, 434 pages and maps, September 23, 1991 PY - 1991 KW - Urban and Social Programs KW - Air Quality Standards Violations KW - Buildings KW - Central Business Districts KW - Employment KW - Floodplains KW - Historic Sites KW - Land Use KW - Leasing KW - Parking KW - Particulates KW - Subsidence KW - Traffic Analyses KW - Urban Development KW - Vegetation KW - Water Quality KW - Water Quality Assessments KW - Wildlife Habitat KW - Maryland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36394271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=HEALTH+CARE+FINANCING+ADMINISTRATION+CONSOLIDATION%2C+BALTIMORE%2C+MARYLAND.&rft.title=HEALTH+CARE+FINANCING+ADMINISTRATION+CONSOLIDATION%2C+BALTIMORE%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Public Buildings Service, Philadelphia, Pennsylvania; GSA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: September 23, 1991 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Occupational noise exposure and hearing loss in fire fighters assigned to airport fire stations. AN - 85244679; pmid-1781442 AB - The National Institute for Occupational Safety and Health (NIOSH) was requested to conduct a health hazard evaluation (HHE) at a large metropolitan fire department. The request concerned the hearing levels and noise exposures of fire fighters who were assigned to two fire stations serving the international airport. There was concern that these fire fighters were at a greater risk of accruing hearing loss than fire fighters located at other fire stations because of the addition of aircraft noise to their occupational noise exposures. The city also requested that NIOSH investigate other fire stations, not influenced by the airport, for noise exposures and hearing ability among a larger population of the fire fighters. NIOSH investigators conducted noise surveys at five fire stations and examined the hearing ability of 197 fire fighters. The noise surveys consisted of personal noise dosimetry on fire fighters assigned to the fire station for the entire 24-hr tour of duty over 2 consecutive days at each of the five stations. A NIOSH investigator accompanied the fire fighters on their vehicle to log response times and activities. The audiometric examinations were pure-tone, air conduction tests administered according to the Occupational Safety and Health Administration's (OSHA's) hearing conservation amendment. The noise dosimetry results revealed time-weighted averages (TWAs) that ranged from 60 to 82 dBA. However, the levels encountered during Code 3 responses (warning lights, sirens, and air horns) reached 109 dBA for a 1-min time period. The audiometric results showed that the average fire fighter exhibited a characteristic noise-induced permanent threshold shift.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American Industrial Hygiene Association Journal AU - Tubbs, R L AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH 45226. PY - 1991 SP - 372 EP - 378 VL - 52 IS - 9 SN - 0002-8894, 0002-8894 KW - Fires KW - Hearing Loss, Noise-Induced KW - Audiometry, Pure-Tone KW - Human KW - Adult KW - Hearing Tests KW - Middle Age KW - Time Factors KW - Male KW - Noise, Occupational KW - Occupational Exposure KW - Aircraft UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85244679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Occupational+noise+exposure+and+hearing+loss+in+fire+fighters+assigned+to+airport+fire+stations.&rft.au=Tubbs%2C+R+L&rft.aulast=Tubbs&rft.aufirst=R&rft.date=1991-09-01&rft.volume=52&rft.issue=9&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Gas chromatographic determination of captan, folpet, and captafol residues in tomatoes, cucumbers, and apples using a wide-bore capillary column: interlaboratory study. AN - 72647650; 1783591 AB - An interlaboratory study of the determination of captan, folpet, and captafol in tomatoes, cucumbers, and apples was conducted by 4 laboratories using wide-bore capillary column gas chromatography with electron capture detection. The 3 fungicides were determined using the Luke et al. multiresidue method modified to include additional solvent elution in the optional Florisil column cleanup step used with this method. The crops were fortified with each fungicide at 3 levels per crop. Mean recoveries ranged from 86.2% for a 25.1 ppm level of captan in apples to 115.4% for a 0.288 ppm level of captafol in apples. Interlaboratory coefficients of variation ranged from 3.4% (24.7 ppm folpet) to 9.7% (0.243 ppm captafol) for tomatoes; from 2.8% (2.0 ppm captafol) to 8.2% (24.8 ppm captan) for cucumbers; and from 1.5% (0.234 ppm folpet) to 22.1% (0.266 ppm captafol) for apples. JF - Journal - Association of Official Analytical Chemists AU - Gilvydis, D M AU - Walters, S M AD - Food and Drug Administration, Pesticides and Industrial Chemicals Research Center, Detroit, MI 48207. PY - 1991 SP - 830 EP - 835 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Cyclohexenes KW - 0 KW - Fungicides, Industrial KW - Pesticide Residues KW - Phthalimides KW - captafol KW - 2425-06-1 KW - Captan KW - EOL5G26Q9F KW - folpet KW - X5NFK36917 KW - Index Medicus KW - Chromatography, Gas -- instrumentation KW - Reproducibility of Results KW - Phthalimides -- analysis KW - Captan -- analogs & derivatives KW - Captan -- analysis KW - Vegetables -- chemistry KW - Fungicides, Industrial -- analysis KW - Pesticide Residues -- analysis KW - Fruit -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72647650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Gas+chromatographic+determination+of+captan%2C+folpet%2C+and+captafol+residues+in+tomatoes%2C+cucumbers%2C+and+apples+using+a+wide-bore+capillary+column%3A+interlaboratory+study.&rft.au=Gilvydis%2C+D+M%3BWalters%2C+S+M&rft.aulast=Gilvydis&rft.aufirst=D&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential inactivation of surrogate viruses with merocyanine 540. AN - 72644056; 1664526 AB - Bacteriophages may be useful as surrogates for animal viruses when the virucidal properties of different photosensitizing compounds are initially investigated. We studied photoinactivation of four bacteriophages, phi X174, T7, PRD1, and phi 6, by the dye merocyanine 540 (MC540) (15 micrograms/mL). Merocyanine 540 (MC540) should be most effective with lipid-containing viruses, since it is primarily lipophilic (but also binds to proteins). Two of the phages, PRD1 and phi 6 contain lipid, with only phi 6 having an external lipoprotein envelope. Filtered radiation (450-600 nm) from a 750 W projector was used at 16-100 W/m2. The survival curves of the different viruses clearly demonstrated different levels of sensitivity to photoinactivation by MC540, with phi 6 (Do = 1.5 kJ/m2) being the most sensitive, followed by T7 (21-fold less sensitive). While both PRD1 and phi 6 have lipid components, only phi 6 was photoinactivated by MC540. Thus the internal lipid components of PRD1 were not sufficient to allow photoinactivation by this dye, at fluences up to 300 kJ/m2. For comparison, we also photoinactivated Herpes simplex virus (Do = 0.053 kJ/m2) and found it to be 28-fold more sensitive than phi 6 to photoinactivation by the same concentration of MC540. Thus phi 6 may be used as a surrogate for enveloped human viruses for photoinactivation by lipophilic dyes, but the results may only be useful qualitatively. JF - Photochemistry and photobiology AU - Lytle, C D AU - Budacz, A P AU - Keville, E AU - Miller, S A AU - Prodouz, K N AD - Center for Devices and Radiological Health, FDA, Rockville, MD 20857. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 489 EP - 493 VL - 54 IS - 3 SN - 0031-8655, 0031-8655 KW - Antiviral Agents KW - 0 KW - Pyrimidinones KW - Radiation-Sensitizing Agents KW - merocyanine dye KW - 58823-12-4 KW - Index Medicus KW - Animals KW - Light KW - Dose-Response Relationship, Radiation KW - Cell Line KW - Simplexvirus -- drug effects KW - Bacteriophages -- growth & development KW - Radiation-Sensitizing Agents -- pharmacology KW - Antiviral Agents -- pharmacology KW - Pyrimidinones -- pharmacology KW - Simplexvirus -- growth & development KW - Bacteriophages -- radiation effects KW - Simplexvirus -- radiation effects KW - Bacteriophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72644056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Differential+inactivation+of+surrogate+viruses+with+merocyanine+540.&rft.au=Lytle%2C+C+D%3BBudacz%2C+A+P%3BKeville%2C+E%3BMiller%2C+S+A%3BProdouz%2C+K+N&rft.aulast=Lytle&rft.aufirst=C&rft.date=1991-09-01&rft.volume=54&rft.issue=3&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-13 N1 - Date created - 1992-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Time required to achieve homogeneity of test substances added to dog feed. AN - 72643869; 1783593 AB - The homogeneity of test substances in a carrier (animal feed) is a critical factor in conducting long-term feeding studies in laboratory animals. A method for determining the adequate amount of mixing to achieve homogeneity by a mixer of the type described has been determined when 2 distinctly different compounds are added to ground dog feed. Nicotinic acid and butylated hydroxyanisole at a concentration of 1% were separately mixed with the dog feed for 15, 30, 45, 60, and 120 min to determine optimum mixing time. Test portions were taken from 4 different sampling sites at each time period and analyzed in duplicate for the added substance. Four batches were prepared and the results were aggregated. Very little interbatch variability was observed. The variance of the average values from the 4 sampling sites at each time period was calculated and used as a simple, crude, but effective numerical quantity to monitor the approach to homogeneity of the mixture. JF - Journal - Association of Official Analytical Chemists AU - Sapienza, P P AU - Ikeda, G J AU - Warr, P I AU - Albert, R H AD - Food and Drug Administration, Division of Toxicological Studies, Beltsville Research Facility, MD 20705. PY - 1991 SP - 857 EP - 861 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Butylated Hydroxyanisole KW - 25013-16-5 KW - Niacin KW - 2679MF687A KW - Index Medicus KW - Butylated Hydroxyanisole -- analysis KW - Niacin -- analysis KW - Spectrophotometry, Ultraviolet KW - Chromatography, Liquid KW - Toxicology -- methods KW - Time Factors KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72643869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Time+required+to+achieve+homogeneity+of+test+substances+added+to+dog+feed.&rft.au=Sapienza%2C+P+P%3BIkeda%2C+G+J%3BWarr%2C+P+I%3BAlbert%2C+R+H&rft.aulast=Sapienza&rft.aufirst=P&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Performance characteristics of methods of analysis used for regulatory purposes. Part II. Pesticide formulations. AN - 72643740; 1783583 AB - The precision parameters of the method-performance (collaborative) studies published in the AOAC Journal from 1915 through 1990 for pesticide formulations have been recalculated on a uniform basis by the International Union of Pure and Applied Chemistry 1987 protocol. About 93% of the 953 accepted assays, which are predominantly gravimetric (G), volumetric (V), and gas (GC) and liquid (LC) chromatographic methods, exhibit relative standard deviations among laboratories (RSDR) that are generally less than 2 times the values predicted from the Horwitz equation: RSDR (%) = 2 exp (1-0.5 log C), where C is the concentration expressed as a decimal fraction. UV, VIS, and IR spectrophotometric (S) methods are somewhat poorer, with about 80% of the reported RSDR values less than twice the predicted RSDR value. The precision parameters of pesticide formulations analyzed by the older methods (G, V, GC) are equivalent to those previously found for drug preparations in the same concentration range; the precision parameters of pesticide formulations analyzed by LC and S are somewhat poorer. Overall, however, the precision parameters of pesticide formulations are generally independent of analyte, method, and matrix, and are primarily a function of concentration. The method-acceptability decisions of the AOAC for pesticide formulations during the past 75 years can be approximated retrospectively by using a criterion for RSDR that is less than 2 times the RSDR calculated from the Horwitz equation. JF - Journal - Association of Official Analytical Chemists AU - Horwitz, W AU - Albert, R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. PY - 1991 SP - 718 EP - 744 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Pesticides KW - 0 KW - Index Medicus KW - Reproducibility of Results KW - Methods KW - Databases, Factual KW - International Agencies KW - Pesticides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72643740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Performance+characteristics+of+methods+of+analysis+used+for+regulatory+purposes.+Part+II.+Pesticide+formulations.&rft.au=Horwitz%2C+W%3BAlbert%2C+R&rft.aulast=Horwitz&rft.aufirst=W&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - FDA monitoring program. Residues in foods--1990. AN - 72641806; 1783581 AB - In 1990, under regulatory monitoring, a total of 19,962 samples of domestically produced food from all 50 states and Puerto Rico and imported food from 92 countries were analyzed by FDA for pesticide residues. Of these, 19,146 were surveillance samples, which are collected when there is no suspicion of a pesticide problem. No residues were found in 60% of domestic surveillance samples and in 64% of import surveillance samples. Of the 19,146 surveillance samples, 2.8% were violative. Under the incidence/level aspect of monitoring, 172 samples of fish/shell-fish, 330 samples of whole milk, and 3502 samples of processed foods including baby foods were analyzed for pesticide residues. Findings from these projects were consistent with regulatory monitoring data. The findings of the 1990 Total Diet Study are evidence that actual dietary intakes of pesticides are generally well below the standards established by FAO/WHO and by EPA. The 1990 results are similar to those obtained in earlier years and demonstrate the continuing safety of the food supply relative to pesticide residues. JF - Journal - Association of Official Analytical Chemists AU - Yess, N J AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 121A EP - 141A VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - State Government KW - International Cooperation KW - Fishes KW - Food-Processing Industry -- standards KW - Animal Feed -- analysis KW - Meat -- analysis KW - Milk -- analysis KW - Food Analysis -- standards KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72641806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=FDA+monitoring+program.+Residues+in+foods--1990.&rft.au=Yess%2C+N+J&rft.aulast=Yess&rft.aufirst=N&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=121A&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Computation of the initially unknown boundaries of flow fields generated by local exhaust hoods. AN - 72639816; 1838234 AB - Local exhaust hoods are important in controlling contaminants in the workplace. To predict hood effectiveness, it is important to have knowledge of the airflow field that it generates. Currently, there are theoretical models adequate for predicting the flow fields of hoods with flanged openings. These models are solutions of Laplace's equation in terms of the velocity potential. Comparison of experimental and theoretical values of air velocities show good agreement. With the exception of the plain slot, no such models are available for plain hoods or other hoods with complex geometries. This paper explores the feasibility of approximating the equal air velocity contours for any local exhaust hood by assuming that these contours are also equipotential contours. A slot configuration, for which an analytical model is available, was used to evaluate the accuracy of the assumption. Starting with a good approximation for the 15% velocity contour, three other boundaries were generated. The procedure used in generating boundaries after the initial one involved solution of Laplace's equation, assuming constant potential along the boundary and adjustment of boundary location on the basis of differences between the calculated value of the normal derivative of the velocity potential at a point on the boundary and the specified value (15%). The next-to-last boundary generated by the procedure exhibited an oscillation in the values of the normal derivative, which was detrimental to the desired solution. Possible causes for this oscillation and possible refinements in the procedure are discussed. JF - American Industrial Hygiene Association journal AU - Anastas, M Y AD - National Institute for Occupational Safety and Health, Cincinnati OH 45226. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 379 EP - 386 VL - 52 IS - 9 SN - 0002-8894, 0002-8894 KW - Index Medicus KW - Rheology KW - Models, Theoretical KW - Environmental Monitoring KW - Air Pollution -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72639816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Computation+of+the+initially+unknown+boundaries+of+flow+fields+generated+by+local+exhaust+hoods.&rft.au=Anastas%2C+M+Y&rft.aulast=Anastas&rft.aufirst=M&rft.date=1991-09-01&rft.volume=52&rft.issue=9&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Efficiency of two commercial ELISA kits compared with the BAM culture method for detecting Listeria in naturally contaminated foods. AN - 72637836; 1783588 AB - The efficiency of 2 commercial enzyme-linked immunosorbent assay (ELISA) kits (Listeria-Tek and Tecra) for detecting Listeria in naturally contaminated foods was evaluated and compared with that of the culture method described in the Bacteriological Analytical Manual (BAM). Both ELISAs use modified University of Vermont (UVM-1) medium as a primary enrichment; the BAM method uses Listeria enrichment broth. Secondary enrichments for Listeria-Tek and Tecra, respectively, were Fraser broth and UVM-2, which contains additional acriflavin-HCl. When ELISA test results differed, secondary enrichments were tested against the other ELISA; Fraser broth was used to determine recovery rates because of its superiority over UVM-2. Of the 178 food samples examined, the presence of Listeria was detected and culturally confirmed in 38, 37, and 40 samples by the BAM, Listeria-Tek, and Tecra methods, respectively. Differences in results of the ELISAs compared with those of the BAM method were not statistically significant; however, differences between results of the 2 ELISA methods were significant. It was concluded that as rapid screening methods, the Listeria-Tek and the Tecra kits qualify as alternative methods to the BAM cultural method. JF - Journal - Association of Official Analytical Chemists AU - Noah, C W AU - Ramos, N C AU - Gipson, M V AD - Food and Drug Administration, Dallas, TX 75204. PY - 1991 SP - 819 EP - 821 VL - 74 IS - 5 SN - 0004-5756, 0004-5756 KW - Reagent Kits, Diagnostic KW - 0 KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay -- instrumentation KW - Colony Count, Microbial KW - Bacteriological Techniques KW - Food Microbiology -- standards KW - Listeria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72637836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Efficiency+of+two+commercial+ELISA+kits+compared+with+the+BAM+culture+method+for+detecting+Listeria+in+naturally+contaminated+foods.&rft.au=Noah%2C+C+W%3BRamos%2C+N+C%3BGipson%2C+M+V&rft.aulast=Noah&rft.aufirst=C&rft.date=1991-09-01&rft.volume=74&rft.issue=5&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-16 N1 - Date created - 1992-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of trinomial responses from reproductive and developmental toxicity experiments. AN - 72505429; 1742429 AB - This paper presents a Dirichlet-trinomial distribution for modelling data obtained from reproductive and developmental studies. The common endpoints for the evaluation of reproductive and developmental toxic effects are the number of dead fetuses, the number of malformed fetuses, and the number of normal fetuses for each litter. With current statistical methods for the evaluation of reproductive and developmental effects, the effect on the number of deaths and the effect on the number of malformations are analyzed separately. The Dirichlet-trinomial model provides a procedure for the analysis of multiple endpoints simultaneously. This proposed Dirichlet-trinomial model is a generalization of the beta-binomial model that has been used for handling the litter effect in reproductive and developmental experiments. Likelihood ratio tests for differences in the number of deaths, the number of malformations, and the number of normals among dosed and control groups are derived. The proposed test procedure based on the Dirichlet-trinomial model is compared with that based on the beta-binomial model with an application to a real data set. JF - Biometrics AU - Chen, J J AU - Kodell, R L AU - Howe, R B AU - Gaylor, D W AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 1049 EP - 1058 VL - 47 IS - 3 SN - 0006-341X, 0006-341X KW - Teratogens KW - 0 KW - Index Medicus KW - Animals KW - Fetus -- drug effects KW - Abnormalities, Drug-Induced KW - Fetal Resorption KW - Models, Statistical KW - Female KW - Pregnancy KW - Mathematics KW - Reproduction -- drug effects KW - Teratogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Analysis+of+trinomial+responses+from+reproductive+and+developmental+toxicity+experiments.&rft.au=Chen%2C+J+J%3BKodell%2C+R+L%3BHowe%2C+R+B%3BGaylor%2C+D+W&rft.aulast=Chen&rft.aufirst=J&rft.date=1991-09-01&rft.volume=47&rft.issue=3&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts. AN - 72461848; 1944329 AB - The mutations and DNA adducts produced by the environmental pollutant 2-nitropyrene were examined in Salmonella typhimurium tester strains. 2-Nitropyrene was a stronger mutagen than its extensively studied structural isomer 1-nitropyrene in strains TA96, TA97, TA98, TA100, TA102, TA104 and TA1538. Both 1- and 2-nitropyrene were essentially inactive in TA1535. The mutagenicity of 1- and 2-nitropyrene in TA98 was much higher than in TA98NR and the activity of these compounds in TA100 was much higher than in TA100NR. While 1-nitropyrene exhibited similar mutagenicity in strains TA98 and TA98/1,8-DNP6, the mutagenicity of 2-nitropyrene in TA98/1,8-DNP6 was much lower than in TA98. Analysis of DNA from TA96 and TA104 incubated with 2-nitropyrene indicated the presence of two adducts, N-(deoxyguanosin-8-yl)-2-aminopyrene and N-(deoxyadenosin-8-yl)-2-aminopyrene. The results suggest that 2-nitropyrene is metabolized by bacterial nitroreductase(s) to N-hydroxy-2-aminopyrene, and possibly by activation to a highly mutagenic O-acetoxy ester. DNA adduct formation with deoxyguanosine and deoxyadenosine correlates with the mutagenicity of 2-nitropyrene in tester strains possessing both G:C and A:T mutational targets. JF - Mutation research AU - Yu, S Y AU - Heflich, R H AU - Von Tungeln, L S AU - el-Bayoumy, K AU - Kadlubar, F F AU - Fu, P P AD - National Center for Toxicological Research, Jefferson, AR 72079. PY - 1991 SP - 145 EP - 152 VL - 250 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Pyrenes KW - Guanine KW - 5Z93L87A1R KW - 2-nitropyrene KW - 789-07-1 KW - Adenine KW - JAC85A2161 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Adenine -- chemistry KW - Mutagenicity Tests KW - Guanine -- chemistry KW - Salmonella typhimurium -- genetics KW - Pyrenes -- toxicity KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Comparative+direct-acting+mutagenicity+of+1-+and+2-nitropyrene%3A+evidence+for+2-nitropyrene+mutagenesis+by+both+guanine+and+adenine+adducts.&rft.au=Yu%2C+S+Y%3BHeflich%2C+R+H%3BVon+Tungeln%2C+L+S%3Bel-Bayoumy%2C+K%3BKadlubar%2C+F+F%3BFu%2C+P+P&rft.aulast=Yu&rft.aufirst=S&rft.date=1991-09-01&rft.volume=250&rft.issue=1-2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-27 N1 - Date created - 1991-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - HIV infection and homeless adolescents. AN - 72445816; 1935331 AB - Homeless adolescents are at extremely high risk for acquiring HIV infection, as the literature reviewed in this paper documents. Sexual and drug use behaviors that put these adolescents at risk are described, and new models of service for these youths are outlined. JF - Child welfare AU - Athey, J L AD - Child and Adolescent Health Branch, Maternal and Child Health Bureau, U.S. Department of Health and Human Services, Rockville, MD. PY - 1991 SP - 517 EP - 528 VL - 70 IS - 5 SN - 0009-4021, 0009-4021 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Sexual Behavior KW - Adolescent Health Services -- trends KW - Humans KW - Substance Abuse, Intravenous -- complications KW - Health Services Needs and Demand -- trends KW - Adolescent KW - Substance Abuse, Intravenous -- prevention & control KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Homeless Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72445816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=HIV+infection+and+homeless+adolescents.&rft.au=Athey%2C+J+L&rft.aulast=Athey&rft.aufirst=J&rft.date=1991-09-01&rft.volume=70&rft.issue=5&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of intercellular communication in Chinese hamster V79 cells by fractionated asphalt fume condensates. AN - 72090671; 1890695 AB - Asphalt fume condensate is a skin carcinogen in mice, yet this complex mixture contains relatively low levels of known carcinogenic initiators. Consequently, its biological activity has been attributed to the presence of cocarcinogenic or tumor-promoting agents. One of several proposed mechanisms of tumor promotion is inhibition of intercellular communication. In an attempt to determine if asphalt fume has tumor-promoting potential inhibition of intercellular communication was measured in V79 cells exposed to fractionated asphalt fume condensate. Fume from air-blown Arabian crude asphalt was trapped and separated into five fractions by preparative-scale high-pressure liquid chromatography. The parent fume condensate and the five fractions inhibited intercellular communication in a concentration-dependent fashion, with a minimum effective concentration of 2.5 microgram/ml for the most potent fraction. Cytotoxicity assays were performed at the same time and concentrations as the metabolic cooperation assays. Cytotoxic responses paralleled the inhibition of intercellular communication. JF - Journal of toxicology and environmental health AU - Toraason, M AU - Bohrman, J S AU - Elmore, E AU - Wyatt, G AU - McGregor, D AU - Willington, S E AU - Zajac, W AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 95 EP - 102 VL - 34 IS - 1 SN - 0098-4108, 0098-4108 KW - Aerosols KW - 0 KW - Hydrocarbons KW - asphalt KW - 8052-42-4 KW - Index Medicus KW - Animals KW - Cell Survival -- drug effects KW - Gas Chromatography-Mass Spectrometry KW - Cell Line KW - Hydrocarbons -- chemistry KW - Cell Communication -- drug effects KW - Hydrocarbons -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72090671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Inhibition+of+intercellular+communication+in+Chinese+hamster+V79+cells+by+fractionated+asphalt+fume+condensates.&rft.au=Toraason%2C+M%3BBohrman%2C+J+S%3BElmore%2C+E%3BWyatt%2C+G%3BMcGregor%2C+D%3BWillington%2C+S+E%3BZajac%2C+W&rft.aulast=Toraason&rft.aufirst=M&rft.date=1991-09-01&rft.volume=34&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-11 N1 - Date created - 1991-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The genetic toxicology of 5-bromodeoxyuridine in mammalian cells. AN - 72061215; 1881403 AB - The thymidine analog, BrdUrd, induces many biological responses which are of importance to the field of genetic toxicology and related disciplines. These include the induction of SCE, specific-locus mutations, and toxicity, inhibition of cell proliferation, and the expression of fragile sites in the human genome. In early models which addressed the mechanisms of the biological effects of BrdUrd exposure, two pathways were proposed to account for the induction of the biological responses. Incorporation of the enol form of BrdUrd into the nascent DNA strand after pairing with deoxyguanosine was proposed as one pathway, whereas the incorporation of BrdUrd opposite adenosine in place of thymidine was proposed as the second pathway. Many novel and sophisticated techniques have been applied to the study of the mechanism of the induction of biological effects by BrdUrd leading to a substantial increase in our understanding of these mechanisms. However, the experimental evidence clearly supports the contention that BrdUrd exerts its effects on eukaryotic cells through mechanisms similar to those originally proposed to explain the genotoxicity of BrdUrd. JF - Mutation research AU - Morris, S M AD - Department of Health and Human Services, U.S. Public Health Service, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 161 EP - 188 VL - 258 IS - 2 SN - 0027-5107, 0027-5107 KW - Chromatin KW - 0 KW - DNA KW - 9007-49-2 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Animals KW - Mammals KW - Sister Chromatid Exchange KW - Chromosome Fragility KW - Chromosome Fragile Sites KW - Chromatin -- drug effects KW - Cell Division -- drug effects KW - Cell Cycle -- drug effects KW - DNA -- metabolism KW - Bromodeoxyuridine -- toxicity KW - Mutagenesis KW - DNA -- drug effects KW - Bromodeoxyuridine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72061215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+genetic+toxicology+of+5-bromodeoxyuridine+in+mammalian+cells.&rft.au=Morris%2C+S+M&rft.aulast=Morris&rft.aufirst=S&rft.date=1991-09-01&rft.volume=258&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-30 N1 - Date created - 1991-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The FDA as an information source for family physicians. AN - 72054176; 1877417 JF - American family physician AU - Rheinstein, P H AD - U.S. Food and Drug Administration, Rockville, Maryland. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 1037 EP - 1041 VL - 44 IS - 3 SN - 0002-838X, 0002-838X KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - United States KW - Periodicals as Topic KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Product Labeling -- standards KW - Diffusion of Innovation KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Drug Therapy -- standards KW - Information Services -- standards KW - Family Practice KW - United States Food and Drug Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72054176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=The+FDA+as+an+information+source+for+family+physicians.&rft.au=Rheinstein%2C+P+H&rft.aulast=Rheinstein&rft.aufirst=P&rft.date=1991-09-01&rft.volume=44&rft.issue=3&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The embryotoxicity of phenytoin: an update on possible mechanisms. AN - 72034619; 1871147 AB - PHT has multiple effects in adult humans and animals, and there is no reason to assume that it will not have multiple effects in embryos and fetuses. Although one of the first associations between anticonvulsant therapy and an adverse development effect in humans was noted in 1964 (104), the mechanism(s) whereby these adverse effects occur has thus far eluded research efforts. In this review, I have focused on three possible mechanisms. Overall, the evidence does not appear to implicate folate deficiency in PHT-induced embryotoxicity. A role for glucocorticoids or interaction between PHT and the glucocorticoid receptor has not been ruled out. However, a significant amount of work remains to be done to examine the involvement of the arachidonic acid cascade in PHT-induced embryotoxicity in vivo. The bulk of the experimental evidence would seem to favor a role for the generation of a reactive intermediate and its subsequent binding to embryonic macromolecules. This metabolite(s) has not been identified. Additionally, the association between covalent binding of metabolites and embryotoxicity remains simply an association; a causal relationship has not been established. Much work remains to be done to determine whether any of these possibilities, some other possibility, or a combination of several mechanisms will explain the adverse development effects of this very important, therapeutically useful anticonvulsant. JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) AU - Hansen, D K AD - Division of Reproductive and Developmental Toxicology, Food and Drug Administration, Department of Health and Human Services, Jefferson, Arkansas 72079. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 361 EP - 368 VL - 197 IS - 4 SN - 0037-9727, 0037-9727 KW - Glucocorticoids KW - 0 KW - Teratogens KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Glucocorticoids -- metabolism KW - Animals KW - Folic Acid Deficiency KW - Biotransformation KW - Humans KW - Phenytoin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72034619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.atitle=The+embryotoxicity+of+phenytoin%3A+an+update+on+possible+mechanisms.&rft.au=Hansen%2C+D+K&rft.aulast=Hansen&rft.aufirst=D&rft.date=1991-09-01&rft.volume=197&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.issn=00379727&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-19 N1 - Date created - 1991-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxic oil syndrome: a current clinical and epidemiologic summary, including comparisons with the eosinophilia-myalgia syndrome. AN - 72032818; 1869734 AB - In the spring and summer of 1981, an epidemic of a new illness now referred to as the toxic oil syndrome occurred in central and northwestern Spain, resulting in some 20,000 cases, 12,000 hospital admissions and greater than 300 deaths in the 1st year of the epidemic. The initial onset of illness was usually acute, and patients presented primarily with a respiratory syndrome involving cough, fever, dyspnea, hypoxemia, pulmonary infiltrates and pleural effusions. While approximately 50% of patients recovered from this acute phase of the illness without apparent sequelae, the remaining patients developed an intermediate or chronic phase, or both, of illness involving severe myalgia, eosinophilia, peripheral nerve damage, sclerodermiform skin lesions, sicca syndrome, alopecia and joint contractures, among other findings. Epidemiologic and analytic chemical studies have clearly linked the toxic oil syndrome to the ingestion of oil mixtures containing rapeseed oil denatured with aniline. However, the precise identity of the etiologic agent within this oil has never been determined. Aniline itself did not cause the illness, but the causal agent may be a reaction product of aniline with some oil component. Although many aspects of disease activity in the involved patients have lessened with time, the ultimate consequences of their disease are not clear and are the subject of ongoing study. The recently described eosinophilia-myalgia syndrome in the United States clinically resembles the toxic oil syndrome. JF - Journal of the American College of Cardiology AU - Kilbourne, E M AU - Posada de la Paz, M AU - Abaitua Borda, I AU - Diez Ruiz-Navarro, M AU - Philen, R M AU - Falk, H AD - Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, Georgia. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 711 EP - 717 VL - 18 IS - 3 SN - 0735-1097, 0735-1097 KW - Aniline Compounds KW - 0 KW - Fatty Acids, Monounsaturated KW - Plant Oils KW - canola oil KW - 331KBJ17RK KW - Tryptophan KW - 8DUH1N11BX KW - aniline KW - SIR7XX2F1K KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Poisoning -- epidemiology KW - Cardiovascular Diseases -- chemically induced KW - Spain -- epidemiology KW - United States -- epidemiology KW - Male KW - Female KW - Tryptophan -- adverse effects KW - Muscular Diseases -- chemically induced KW - Eosinophilia -- chemically induced KW - Muscular Diseases -- epidemiology KW - Eosinophilia -- epidemiology KW - Disease Outbreaks KW - Plant Oils -- poisoning KW - Brassica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72032818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Toxic+oil+syndrome%3A+a+current+clinical+and+epidemiologic+summary%2C+including+comparisons+with+the+eosinophilia-myalgia+syndrome.&rft.au=Kilbourne%2C+E+M%3BPosada+de+la+Paz%2C+M%3BAbaitua+Borda%2C+I%3BDiez+Ruiz-Navarro%2C+M%3BPhilen%2C+R+M%3BFalk%2C+H&rft.aulast=Kilbourne&rft.aufirst=E&rft.date=1991-09-01&rft.volume=18&rft.issue=3&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-19 N1 - Date created - 1991-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Alcohol practices, policies, and potentials of American colleges and universities: an OSAP white paper AN - 59571088; 1992-0111248 AB - Extent of drinking on college campuses, costs, areas of intervention open to schools, and remedies; US. JF - 5600 Fishers Lane, Rockwall II, Rockville, MD 20857, September 1991. iv+75 pp. AU - Eigen, Lewis D Y1 - 1991/09// PY - 1991 DA - September 1991 EP - iv+75 PB - 5600 Fishers Lane, Rockwall II, Rockville, MD 20857 KW - Colleges and universities -- Administration KW - United States -- Educational sector KW - Alcoholism -- United States KW - College students -- Liquor problem KW - Drinking behavior -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59571088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Eigen%2C+Lewis+D&rft.aulast=Eigen&rft.aufirst=Lewis&rft.date=1991-09-01&rft.volume=&rft.issue=&rft.spage=iv%2B75&rft.isbn=&rft.btitle=Alcohol+practices%2C+policies%2C+and+potentials+of+American+colleges+and+universities%3A+an+OSAP+white+paper&rft.title=Alcohol+practices%2C+policies%2C+and+potentials+of+American+colleges+and+universities%3A+an+OSAP+white+paper&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - 5600 Fishers Lane, Rockwall II, Rockville, MD 20857 pa N1 - Document feature - table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Interaction of forskolin with the P-glycoprotein multidrug transporter. AN - 72072279; 1679346 AB - Forskolin and 1,9-dideoxyforskolin, an analogue that does not activate adenylyl cyclase, were tested for their ability to enhance the cytotoxic effects of adriamycin in human ovarian carcinoma cells, SKOV3, which are sensitive to adriamycin and express low levels of P-glycoprotein, and a variant cell line, SKVLB, which overexpresses the P-glycoprotein and has the multidrug resistance (MDR) phenotype. Forskolin and 1,9-dideoxyforskolin both increased the cytotoxic effects of adriamycin in SKVLB cells, yet had no effect on SKOV3 cells. Two photoactive derivatives of forskolin have been synthesized, 7-O-[[2-[3-(4-azido-3- [125I]iodophenyl)propionamido]ethyl] carbamyl]-7-deacetylforskolin, 125I-7-AIPP-Fsk, and 6-O-[[2-[3-(4-azido-3- [125I]iodophenyl)propionamido]ethyl]carbamyl]forskolin, 125I-6-AIPP-Fsk, which exhibit specificity for labeling the glucose transporter and adenylyl cyclase, respectively (Morris et al., 1991). Both photolabels identified a 140-kDa protein in membranes from SKVLB cells whose labeling was inhibited by forskolin and 1,9-dideoxyforskolin. There was no specific labeling of proteins in membranes from the SKOV3 cells. The overexpressed 140-kDa protein in SKVLB membranes was identified as the P-glycoprotein by immunoblot analysis and immunoprecipitation using anti-P-glycoprotein antiserum. Total inhibition of photolabeling of the P-glycoprotein was observed with verapamil, nifedipine, diltiazem, and vinbalastine, and partial inhibition was observed with colchicine and cytochalasin B. Forskolin was less effective at inhibiting the photolabeling of the P-glycoprotein than 1,9-dideoxyforskolin or a lipophilic derivative of forskolin. The data are consistent with forskolin binding to the P-glycoprotein analogous to that of other chemosensitizing drugs that have been shown to partially reverse MDR.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Biochemistry AU - Morris, D I AU - Speicher, L A AU - Ruoho, A E AU - Tew, K D AU - Seamon, K B AD - Molecular Pharmacology Laboratory, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1991/08/27/ PY - 1991 DA - 1991 Aug 27 SP - 8371 EP - 8379 VL - 30 IS - 34 SN - 0006-2960, 0006-2960 KW - Affinity Labels KW - 0 KW - Carrier Proteins KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - Colforsin KW - 1F7A44V6OU KW - Doxorubicin KW - 80168379AG KW - 1,9-dideoxyforskolin KW - OAW710HWIX KW - Index Medicus KW - Drug Interactions KW - Tumor Cells, Cultured KW - Humans KW - Molecular Sequence Data KW - Drug Resistance KW - Cell Membrane -- chemistry KW - Doxorubicin -- toxicity KW - Amino Acid Sequence KW - Molecular Weight KW - Female KW - Cell Line KW - Colforsin -- pharmacology KW - Carrier Proteins -- metabolism KW - Colforsin -- analogs & derivatives KW - Neoplasm Proteins -- metabolism KW - Colforsin -- metabolism KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72072279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Interaction+of+forskolin+with+the+P-glycoprotein+multidrug+transporter.&rft.au=Morris%2C+D+I%3BSpeicher%2C+L+A%3BRuoho%2C+A+E%3BTew%2C+K+D%3BSeamon%2C+K+B&rft.aulast=Morris&rft.aufirst=D&rft.date=1991-08-27&rft.volume=30&rft.issue=34&rft.spage=8371&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-04 N1 - Date created - 1991-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Frequency of urination and its effects on metabolism, pharmacokinetics, blood hemoglobin adduct formation, and liver and urinary bladder DNA adduct levels in beagle dogs given the carcinogen 4-aminobiphenyl. AN - 80736223; 1868460 AB - The human urinary bladder carcinogen, 4-aminobiphenyl (ABP), is known to undergo hepatic metabolism to an N-hydroxy arylamine and its corresponding N-glucuronide. It has been proposed that these metabolites are both transported through the blood via renal filtration to the urinary bladder lumen where acidic pH can facilitate the hydrolysis of the N-glucuronide and enhance the conversion of N-hydroxy-4-aminobiphenyl (N-OH-ABP) to a reactive electrophile that will form covalent adducts with urothelial DNA. Blood ABP-hemoglobin adducts, which have been used to monitor human exposure to ABP, are believed to be formed by reactions within the erythrocyte involving N-OH-ABP that has entered the circulation from the liver or from reabsorption across the urothelium. To test these hypotheses directly, experimental data were obtained from female beagles given [3H]ABP (p.o., i.v., or intraurethrally). [3H]N-OH-ABP (i.v. or intraurethrally), or [3H]N-OH-ABP N-glucuronide (i.v.). Analyses included determinations of total ABP in whole blood and plasma, ABP-hemoglobin adducts in blood erythrocytes, ABP and N-OH-ABP levels (free and N-glucuronide) in urine, urine pH, frequency of urination (controlled by urethral catheter), rates of reabsorption of ABP and N-OH-ABP across the urothelium, and apparent volumes of distribution in the blood/tissue compartment. The major ABP-DNA adduct, N-(guan-8-yl)-4-aminobiphenyl, was also measured in urothelial and liver DNA using a sensitive immunochemical method. An analog/digital hybrid computer was then utilized to construct a multicompartmental pharmacokinetic model for ABP and its metabolites that separates: (a) absorption; (b) hepatic metabolism and distribution in blood and tissues; (c) ABP-hemoglobin adduct formation; (d) hydrolysis and reabsorption in the urinary bladder lumen; and (e) excretion. Using this model, cumulative exposure of the urothelium to free N-OH-ABP was simulated from the experimental data and used to predict ABP-DNA adduct formation in the urothelium. The results indicated that exposure to N-OH-ABP and subsequent ABP-DNA adduct formation are directly dependent on voiding frequency and to a lesser extent on urine pH. This was primarily due to the finding that, after p.o. dosing of ABP to dogs, the major portion of the total N-OH-ABP entering the bladder lumen was free N-OH-ABP (0.7% of the dose), with much lower amounts as the acid-labile N-glucuronide (0.3% of the dose).(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cancer research AU - Kadlubar, F F AU - Dooley, K L AU - Teitel, C H AU - Roberts, D W AU - Benson, R W AU - Butler, M A AU - Bailey, J R AU - Young, J F AU - Skipper, P W AU - Tannenbaum, S R AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/08/15/ PY - 1991 DA - 1991 Aug 15 SP - 4371 EP - 4377 VL - 51 IS - 16 SN - 0008-5472, 0008-5472 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - Hemoglobins KW - 4-biphenylamine KW - 16054949HJ KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Kinetics KW - Dogs KW - Tissue Distribution KW - Time Factors KW - Models, Biological KW - Female KW - Urinary Bladder -- metabolism KW - Aminobiphenyl Compounds -- urine KW - Aminobiphenyl Compounds -- pharmacokinetics KW - Aminobiphenyl Compounds -- blood KW - Carcinogens -- metabolism KW - Urination KW - Hemoglobins -- metabolism KW - DNA -- metabolism KW - Liver -- metabolism KW - Aminobiphenyl Compounds -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80736223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Frequency+of+urination+and+its+effects+on+metabolism%2C+pharmacokinetics%2C+blood+hemoglobin+adduct+formation%2C+and+liver+and+urinary+bladder+DNA+adduct+levels+in+beagle+dogs+given+the+carcinogen+4-aminobiphenyl.&rft.au=Kadlubar%2C+F+F%3BDooley%2C+K+L%3BTeitel%2C+C+H%3BRoberts%2C+D+W%3BBenson%2C+R+W%3BButler%2C+M+A%3BBailey%2C+J+R%3BYoung%2C+J+F%3BSkipper%2C+P+W%3BTannenbaum%2C+S+R&rft.aulast=Kadlubar&rft.aufirst=F&rft.date=1991-08-15&rft.volume=51&rft.issue=16&rft.spage=4371&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-13 N1 - Date created - 1991-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo treatment with interferon causes augmentation of IL-2 induced lymphokine-activated killer cells in the organs of mice. AN - 80719105; 1713814 AB - Interferon-alpha (IFN-alpha) has been shown to synergize with IL-2 in the regression of a variety of established murine tumours and studies are underway to explore this combination in patients with advanced cancers as well. To understand the mechanism of synergy we have studied lymphokine-activated killer (LAK) cell activity in various compartments of mice in response to IFN-alpha and IL-2 administration. The effects of IFN-gamma, TNF-alpha and IL-4 were also examined. C57BL/6 mice were injected intraperitoneally with HBSS, IL-2 alone, IFN-alpha alone or both, two times a day for 7 days. On days 4 and 8, LAK activity was tested in a 4-h chromium release in cells obtained from lungs, spleen, and liver using fresh MCA-102 tumour cells as targets. The cells from control mice failed to lyse the MCA-102 target. IL-2 caused the generation of LAK activity and an increase in total cell yield in all the organs after 3 days of injection. IFN-alpha failed to generate LAK activity but when administered along with IL-2, caused synergistic enhancement of LAK lysis of MCA-102 target cells. Cell yield in this group was lower as compared with the IL-2-treated group. LAK activity tested after 7 days of IL-2 therapy was significantly decreased compared with that observed after 3 days. However, activity remained at as high a level after 7 days of therapy as after 3 days of therapy in animals treated with IFN-alpha and IL-2. FACS analysis revealed that asialo GM-1+ (ASGM-1) and NK1.1+ cells were increased in number in IL-2 and IL-2 plus IFN-alpha-treated spleen; however, the number of these cells was similar in both groups. In the liver, ASGM-1+ cells were higher in the IL-2 plus IFN-alpha group than in the group treated with IL-2 alone. By in vitro depletion utilizing antibody and Rbc' experiments, it was clear that both ASGM-1+ and NK1.1+ cells from the spleen mediated most of the cytotoxicity of MCA-102 targets. Pre-treatment irradiation (5 Gy) of mice completely abrogated the capability of IL-2 or IL-2 plus IFN-alpha to generate LAK activity. IFN-gamma also had a stimulatory effect on IL-2 induction of LAK activity. Tumour necrosis factor-alpha (TNF-alpha) and IL-4 failed to generate LAK activity and, in combination with IL-2, no additional stimulatory effect was observed.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Clinical and experimental immunology AU - Puri, R K AU - Leland, P AD - Laboratory of Cellular Immunology, Division of Cytokine Biology, FDA, Bethesda, MD 20892. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 317 EP - 325 VL - 85 IS - 2 SN - 0009-9104, 0009-9104 KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Interleukin-4 KW - 207137-56-2 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Phenotype KW - Lymphocyte Activation KW - Animals KW - Recombinant Proteins -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Interleukin-4 -- pharmacology KW - Mice, Inbred C57BL KW - Mice KW - Drug Synergism KW - Fluorescent Antibody Technique KW - Female KW - Interleukin-2 -- pharmacology KW - Killer Cells, Lymphokine-Activated -- drug effects KW - Interferons -- pharmacology KW - Killer Cells, Lymphokine-Activated -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80719105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+immunology&rft.atitle=In+vivo+treatment+with+interferon+causes+augmentation+of+IL-2+induced+lymphokine-activated+killer+cells+in+the+organs+of+mice.&rft.au=Puri%2C+R+K%3BLeland%2C+P&rft.aulast=Puri&rft.aufirst=R&rft.date=1991-08-01&rft.volume=85&rft.issue=2&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+immunology&rft.issn=00099104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-11 N1 - Date created - 1991-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1978 Feb 15;21(2):210-20 [627428] J Exp Med. 1977 Jan 1;145(1):1-9 [187714] Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5 [4501586] Clin Exp Immunol. 1991 Jan;83(1):96-101 [1703057] J Clin Oncol. 1989 Dec;7(12):1863-74 [2685181] J Cell Physiol. 1987 Feb;130(2):276-83 [3102507] J Immunol. 1986 Jul 15;137(2):715-22 [2873187] J Immunol. 1986 Mar 1;136(5):1586-91 [2936802] J Natl Cancer Inst. 1988 May 18;80(6):425-31 [3130488] Int J Cancer. 1988 Feb 15;41(2):315-22 [3123404] Int J Cancer. 1987 Oct 15;40(4):519-24 [2444544] Cancer Res. 1988 Jan 15;48(2):260-4 [2446744] Int J Cancer. 1986 May 15;37(5):787-93 [2422129] J Immunol. 1985 Oct;135(4):2483-91 [2411797] J Immunol. 1985 Feb;134(2):977-81 [2578167] J Immunol. 1989 Dec 15;143(12):4282-6 [2512355] Cancer Res. 1988 Oct 15;48(20):5810-7 [3262413] Cancer Res. 1988 Jul 15;48(14):4011-7 [3260130] Hybridoma. 1984 Fall;3(3):301-3 [6500587] Cancer Treat Rep. 1986 May;70(5):619-24 [3518925] Int J Cancer. 1984 Sep 15;34(3):421-6 [6480158] Int J Cancer. 1987 Sep 15;40(3):365-71 [3497883] N Engl J Med. 1987 Apr 9;316(15):889-97 [3493432] J Exp Med. 1987 Sep 1;166(3):792-7 [3498002] Science. 1987 Feb 20;235(4791):895-8 [3580039] Cancer Res. 1987 Apr 15;47(8):2020-7 [3828990] J Leukoc Biol. 1985 May;37(5):597-614 [3884721] J Immunol. 1985 Aug;135(2):1488-97 [3891854] J Exp Med. 1985 May 1;161(5):1169-88 [3886826] Cancer Res. 1990 Sep 1;50(17):5543-50 [2386960] Cancer Res. 1990 Feb 15;50(4):1176-82 [2297766] J Immunol. 1984 Aug;133(2):714-8 [6203975] J Cell Sci. 1981 Jun;49:225-36 [6171576] Nature. 1981 May 28;291(5813):335-8 [6164929] J Exp Med. 1982 Jun 1;155(6):1823-41 [6176669] Int J Cancer. 1982 Dec 15;30(6):813-20 [6186614] J Immunol. 1980 Jan;124(1):199-201 [6985637] Nature. 1972 Sep 15;239(5368):167-8 [4561966] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Age-specific differences in the relationship between oral contraceptive use and breast cancer. AN - 80673609; 2067757 AB - Nearly all studies have suggested that the use of oral contraceptives (OC) is not associated with the aggregate risk of breast cancer diagnosed in women aged 20-54. Because of age-specific differences in the breast cancer-parity relationship and because of age-specific differences in other breast cancer risk factors, the Centers for Disease Control reexamined data from the Cancer and Steroid Hormone Study to assess whether OC use has different effects on the risk of breast cancer at different ages of diagnosis. This was a population-based case-control study conducted in eight geographic areas in the United States during 1980-1982. In these data, the relationship between the risk of breast cancer and OC use appeared to vary by age at diagnosis. Among women aged 20-34 years at diagnosis or interview, those who had ever used OC had a slightly increased risk of breast cancer (odds ratio 1.4, 95% confidence interval 1.0-2.1) when compared with women of the same ages who had never used OC. Among these women, there were no trends of increasing or decreasing risk with any measure of OC use. Among women aged 35-44 years, there was no association between OC use and breast cancer. Among women aged 45-54 years, those who used OC had a slightly decreased risk of breast cancer (odds ratio 0.9, 95% confidence interval 0.8-1.0). Among these women, the risk estimates decreased significantly with increasing time since first and last use. Although the slightly increased risk estimates for the youngest women are compatible with findings by other investigators, the decreased risk estimates for the oldest women have not been described in as many studies. Available data provide no reasons for changes in prescribing practices or in the use of OC as related to breast cancer risk. JF - Obstetrics and gynecology AU - Wingo, P A AU - Lee, N C AU - Ory, H W AU - Beral, V AU - Peterson, H B AU - Rhodes, P AD - Division of Reproductive Health, Centers for Disease Control, Department of Health and Human Services, Atlanta, Georgia. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 161 EP - 170 VL - 78 IS - 2 SN - 0029-7844, 0029-7844 KW - Contraceptives, Oral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Odds Ratio KW - Age Factors KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Confidence Intervals KW - Middle Aged KW - Female KW - Contraceptives, Oral -- adverse effects KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80673609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Age-specific+differences+in+the+relationship+between+oral+contraceptive+use+and+breast+cancer.&rft.au=Wingo%2C+P+A%3BLee%2C+N+C%3BOry%2C+H+W%3BBeral%2C+V%3BPeterson%2C+H+B%3BRhodes%2C+P&rft.aulast=Wingo&rft.aufirst=P&rft.date=1991-08-01&rft.volume=78&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-09 N1 - Date created - 1991-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic marijuana smoke exposure in the rhesus monkey. I. Plasma cannabinoid and blood carboxyhemoglobin concentrations and clinical chemistry parameters. AN - 72597163; 1684942 AB - This report is the first in a series about a large multidisciplinary study designed to determine whether chronic marijuana (MJ) smoke exposure results in residual behavioral and/or neuropathological alterations in the rhesus monkey. Prior to the initiation of a year of chronic MJ smoke exposure, 64 periadolescent male rhesus monkeys were trained for 1 year to perform five operant behavioral tasks and then divided, according to their performance in these tasks, into four exposure groups (n = 15-16/group): (1) a high dose (HI) group, exposed 7 days/week to the smoke of one standard MJ cigarette; (2) a low dose (LO) group, exposed on weekend days only to the smoke of a standard MJ cigarette; (3) an extracted MJ cigarette (EX) group, exposed 7 days/week to the smoke of one ethanol-extracted MJ cigarette; and (4) a sham group (SH), exposed 7 days/week to sham exposure conditions. Daily exposures for 1 year were accomplished using a mask that covered the subjects' nose and mouth. Average body weights (initially 3.7 +/- 0.5 kg, mean +/- SD) and rates of weight gain (approximately 0.1 kg/month) were the same for all groups throughout the entire experiment. During the first week of exposure, plasma concentrations of delta-9-tetrahydrocannabinol and 11-nor-9-carboxy-THC in the HI group were 59 +/- 7 (mean +/- SE) and 5.5 +/- 1.5 ng/ml, respectively, 45 min after MJ smoke administration and did not change significantly at similar times after exposure throughout the remainder of the year. Whole blood carboxyhemoglobin levels increased to approximately 13% 1 min after exposure to smoke in either the MJ or the EX groups. Comparison of blood chemistry and hematology values before, during, and after exposure indicated no differences for most parameters. During exposure, lymphocytes, alkaline phosphatase and gamma-glutamyl transferase were depressed in the HI group compared to in the SH group. During exposure, aspartate aminotransferase was elevated for both the HI and EX groups, suggesting a general effect of smoke exposure. Because these effects were transient and remained within the range of reported normal values, these data indicate that long-term, experimental exposure to MJ smoke is feasible and does not compromise the general health of the rhesus monkey. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Slikker, W AU - Paule, M G AU - Ali, S F AU - Scallet, A C AU - Bailey, J R AD - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 321 EP - 334 VL - 17 IS - 2 SN - 0272-0590, 0272-0590 KW - Cannabinoids KW - 0 KW - 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid KW - 4TPC9E4A32 KW - Dronabinol KW - 7J8897W37S KW - Carboxyhemoglobin KW - 9061-29-4 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Blood Chemical Analysis KW - Dronabinol -- blood KW - Alkaline Phosphatase -- blood KW - Nervous System Diseases -- chemically induced KW - Nervous System Diseases -- pathology KW - Leukocyte Count KW - Neutrophils -- drug effects KW - Aspartate Aminotransferases -- blood KW - Dronabinol -- analogs & derivatives KW - Body Weight -- drug effects KW - gamma-Glutamyltransferase -- blood KW - Macaca mulatta KW - Male KW - Carboxyhemoglobin -- metabolism KW - Cannabinoids -- blood KW - Marijuana Smoking -- metabolism KW - Marijuana Smoking -- adverse effects KW - Cannabinoids -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72597163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Chronic+marijuana+smoke+exposure+in+the+rhesus+monkey.+I.+Plasma+cannabinoid+and+blood+carboxyhemoglobin+concentrations+and+clinical+chemistry+parameters.&rft.au=Slikker%2C+W%3BPaule%2C+M+G%3BAli%2C+S+F%3BScallet%2C+A+C%3BBailey%2C+J+R&rft.aulast=Slikker&rft.aufirst=W&rft.date=1991-08-01&rft.volume=17&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-19 N1 - Date created - 1992-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Universal precautions and mortuary practitioners: influence on practices and risk of occupationally acquired infection. AN - 72456745; 1941282 AB - Embalming, the most common funeral practice in the United States, may expose the embalmer to infectious diseases and blood. We surveyed the 860 members of the National Selected Morticians in 1988 to estimate the incidence of self-reported occupational contact with blood and infectious disease, assess morticians' knowledge of acquired immunodeficiency syndrome (AIDS), determine their adherence to universal precautions, and identify predictors of practices designed to reduce risk of occupational exposure to infections. Of 539 (63%) respondents, 212 (39%) reported needle-stick injuries in the past 12 months, and 15 (3%) reported percutaneous exposures to the blood of a decedent with AIDS. Those rating the risk of occupationally acquired human immunodeficiency virus infection as very high or high (194/539 [36%]) were more likely to decline funerals of decedents with antemortem diagnosis of AIDS (59/194 [30%]) and/or to charge more for such funerals (133/194 [69%]) than those who rated the risk as low to moderate (31/345 [9%], 174/135 [51%]). JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Beck-Sagué, C M AU - Jarvis, W R AU - Fruehling, J A AU - Ott, C E AU - Higgins, M T AU - Bates, F L AD - Hospital Infections Program, Centers for Disease Control, Public Health Service, Atlanta, GA 30333. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 874 EP - 878 VL - 33 IS - 8 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - AIDS/HIV KW - Canada -- epidemiology KW - Protective Clothing KW - Embalming KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Wounds, Penetrating -- complications KW - United States -- epidemiology KW - Male KW - Prevalence KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Communicable Disease Control -- statistics & numerical data KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Mortuary Practice KW - Occupational Diseases -- prevention & control KW - Acquired Immunodeficiency Syndrome -- transmission KW - Health Knowledge, Attitudes, Practice KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72456745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Universal+precautions+and+mortuary+practitioners%3A+influence+on+practices+and+risk+of+occupationally+acquired+infection.&rft.au=Beck-Sagu%C3%A9%2C+C+M%3BJarvis%2C+W+R%3BFruehling%2C+J+A%3BOtt%2C+C+E%3BHiggins%2C+M+T%3BBates%2C+F+L&rft.aulast=Beck-Sagu%C3%A9&rft.aufirst=C&rft.date=1991-08-01&rft.volume=33&rft.issue=8&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-06 N1 - Date created - 1991-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monitoring the performance of occupational health laboratories. AN - 72163355; 1656722 AB - To monitor the performance of occupational health laboratories analyzing workplace air, the American Industrial Hygiene Association (AIHA), with assistance from the National Institute for Occupational Safety and Health, has established four national quality assurance programs. They are the Proficiency Analytical Testing (PAT) Program, the AIHA Laboratory Accreditation Program, the Asbestos Analysts Registry, and the Bulk Quality Assurance Program. This paper focuses on the PAT program, a quality audit program that provides samples of asbestos, silica, metals, and solvents to laboratories quarterly. PAT data for asbestos, silica, and lead were examined for trends in precision. Simple graphs of coefficient of variation during the 18-yr history of the program provide evidence of improved agreement among laboratories performing these analyses. The improvement took place in spite of growth in the number of laboratories and decreases in the levels being analyzed. The improvement is attributed to several factors, including improved analytical methods and the very existence of the PAT and AIHA Laboratory Accreditation Programs. JF - American Industrial Hygiene Association journal AU - Abell, M T AU - Doemeny, L J AD - Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 336 EP - 339 VL - 52 IS - 8 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Asbestos KW - 1332-21-4 KW - Lead KW - 2P299V784P KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Asbestos -- analysis KW - Silicon Dioxide -- analysis KW - Air Pollutants, Occupational -- analysis KW - Humans KW - Environmental Monitoring -- standards KW - Quality Control KW - Lead -- analysis KW - Occupational Health KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72163355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Monitoring+the+performance+of+occupational+health+laboratories.&rft.au=Abell%2C+M+T%3BDoemeny%2C+L+J&rft.aulast=Abell&rft.aufirst=M&rft.date=1991-08-01&rft.volume=52&rft.issue=8&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-01 N1 - Date created - 1991-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Too much of a good thing? Questions about fluorosis explored. AN - 72140832; 1918691 JF - Journal of the American Dental Association (1939) AU - Mason, J O AD - News Division, Public Health Service, Washington, D.C. 20201. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 93 EP - 96 VL - 122 IS - 8 SN - 0002-8177, 0002-8177 KW - Carcinogens KW - 0 KW - Mouthwashes KW - Toothpastes KW - Fluorides KW - Q80VPU408O KW - Dentistry KW - Index Medicus KW - Bone Neoplasms -- chemically induced KW - Humans KW - Mouthwashes -- adverse effects KW - Toothpastes -- adverse effects KW - Fluorosis, Dental -- etiology KW - Fluorosis, Dental -- epidemiology KW - Fluoridation -- adverse effects KW - Fluorides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72140832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Too+much+of+a+good+thing%3F+Questions+about+fluorosis+explored.&rft.au=Mason%2C+J+O&rft.aulast=Mason&rft.aufirst=J&rft.date=1991-08-01&rft.volume=122&rft.issue=8&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-13 N1 - Date created - 1991-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bacterial mutagenicity testing of 49 food ingredients gives very few positive results. AN - 72035995; 1870621 AB - 49 substances permitted for use in food in the United States was tested for mutagenicity in the Ames Salmonella typhimurium assay and in Escherichia coli strain WP2. Four of these substances caused increases in revertant counts in S. typhimurium. Two of these four (papain and pepsin) were found to contain histidine, and therefore the results of the tests on these two substances could not be taken as demonstrating mutagenicity. The other two substances causing increases in revertant counts (hydrogen peroxide and potassium nitrite) were mutagenic. The results on one chemical, beta-carotene, were evaluated as inconclusive or questionable. The remaining 44 substances were nonmutagenic in the test systems used. It is concluded that, for those generally physiologically innocuous chemicals tested, there are very few 'false positives' in the bacterial test systems used. JF - Mutation research AU - Prival, M J AU - Simmon, V F AU - Mortelmans, K E AD - Toxicology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 321 EP - 329 VL - 260 IS - 4 SN - 0027-5107, 0027-5107 KW - Food Additives KW - 0 KW - Mutagens KW - beta Carotene KW - 01YAE03M7J KW - Carotenoids KW - 36-88-4 KW - Histidine KW - 4QD397987E KW - Index Medicus KW - Histidine -- chemistry KW - Carotenoids -- toxicity KW - Mutagenicity Tests KW - Escherichia coli -- drug effects KW - Salmonella typhimurium -- drug effects KW - Food Additives -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72035995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Bacterial+mutagenicity+testing+of+49+food+ingredients+gives+very+few+positive+results.&rft.au=Prival%2C+M+J%3BSimmon%2C+V+F%3BMortelmans%2C+K+E&rft.aulast=Prival&rft.aufirst=M&rft.date=1991-08-01&rft.volume=260&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-17 N1 - Date created - 1991-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Family-centered comprehensive care for children with HIV infection: a guide AN - 59589155; 1992-0203837 AB - Scope of the problem, elements of care, and organizing, coordinating, and financing a system of community based care programs. JF - 5600 Fishers Lane, Rockville, MD 20857, August 1991. 91 pp. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 91 PB - 5600 Fishers Lane, Rockville, MD 20857 KW - Children -- Medical care KW - Child health -- United States KW - United States -- Health policy KW - Social service -- Work with families KW - Community health services -- United States KW - Acquired immune deficiency syndrome -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59589155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Family-centered+comprehensive+care+for+children+with+HIV+infection%3A+a+guide&rft.title=Family-centered+comprehensive+care+for+children+with+HIV+infection%3A+a+guide&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - 5600 Fishers Lane, Rockville, MD 20857 pa N1 - Document feature - il(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Effects of weathering on metal releases from an engineered deposit for alum shale leaching residues AN - 50486759; 1992-007229 JF - Water, Air and Soil Pollution AU - Allard, B AU - Arsenie, I AU - Hakansson, K AU - Karlsson, S AU - Ahlberg, A C AU - Lundgren, T AU - Collin, M AU - Rasmuson, A AU - Strandell, E A2 - Adriano, Domy C. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 431 EP - 440 PB - Reidel, Dordrecht VL - 57-58 SN - 0049-6979, 0049-6979 KW - copper KW - Europe KW - alum KW - Ranstad KW - iron KW - Billingen Mountain KW - sedimentary rocks KW - environmental geology KW - geochemistry KW - Western Europe KW - sulfates KW - shale KW - pollution KW - weathering KW - Scandinavia KW - metals KW - nickel KW - uranium KW - waste disposal KW - leaching KW - clastic rocks KW - actinides KW - Sweden KW - field studies KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50486759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air+and+Soil+Pollution&rft.atitle=Effects+of+weathering+on+metal+releases+from+an+engineered+deposit+for+alum+shale+leaching+residues&rft.au=Allard%2C+B%3BArsenie%2C+I%3BHakansson%2C+K%3BKarlsson%2C+S%3BAhlberg%2C+A+C%3BLundgren%2C+T%3BCollin%2C+M%3BRasmuson%2C+A%3BStrandell%2C+E&rft.aulast=Allard&rft.aufirst=B&rft.date=1991-08-01&rft.volume=57-58&rft.issue=&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air+and+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ L2 - http://www.springerlink.com/(hi4cjunvnzs4hnradzi0ib55)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100344,1 LA - English DB - GeoRef N1 - Conference title - Metals in soils, waters, plants and animals N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - WAPLAC N1 - SubjectsTermNotLitGenreText - actinides; alum; Billingen Mountain; clastic rocks; copper; environmental geology; Europe; field studies; geochemistry; iron; leaching; metals; nickel; pollution; Ranstad; Scandinavia; sedimentary rocks; shale; sulfates; Sweden; uranium; waste disposal; weathering; Western Europe ER - TY - JOUR T1 - Response of alveolar macrophages to in vitro exposure to freshly fractured versus aged silica dust: the ability of Prosil 28, an organosilane material, to coat silica and reduce its biological reactivity. AN - 80703257; 1649918 AB - We have reported previously that crushing or grinding crystalline silica results in the generation of silica-based radicals on the particulate surface and that these radicals can generate hydroxyl radicals in aqueous solution. Data in the present study indicate that freshly ground silica is more cytotoxic and is a more potent activator of alveolar macrophages than comparably sized aged silica. That is, compared to aged silica, fresh silica is 4.2-fold more potent in decreasing the membrane integrity of macrophages; is 50% more potent in activating hydrogen peroxide secretion by macrophages; and is 4.6-fold more potent in stimulating cellular chemiluminescence. Prosil 28, an organosilane material, is an effective coating agent for fresh silica. It decreases the cytotoxicity of fresh silica by as much as 78% and decreases the ability of fresh silica to induce chemiluminescence from alveolar macrophages by 58%. The data suggest that surface radicals associated with freshly cleaved dust may be an important factor in the induction of pulmonary disease. Furthermore, treating dust with coating agents may substantially decrease toxicity. JF - Journal of toxicology and environmental health AU - Vallyathan, V AU - Kang, J H AU - Van Dyke, K AU - Dalal, N S AU - Castranova, V AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 303 EP - 315 VL - 33 IS - 3 SN - 0098-4108, 0098-4108 KW - Silanes KW - 0 KW - Silicon Dioxide KW - 7631-86-9 KW - Prosil 28 KW - 81138-65-0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Hydrogen Peroxide -- metabolism KW - Male KW - Pulmonary Alveoli -- metabolism KW - Silanes -- pharmacology KW - Pulmonary Alveoli -- drug effects KW - Silicon Dioxide -- toxicity KW - Macrophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80703257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Response+of+alveolar+macrophages+to+in+vitro+exposure+to+freshly+fractured+versus+aged+silica+dust%3A+the+ability+of+Prosil+28%2C+an+organosilane+material%2C+to+coat+silica+and+reduce+its+biological+reactivity.&rft.au=Vallyathan%2C+V%3BKang%2C+J+H%3BVan+Dyke%2C+K%3BDalal%2C+N+S%3BCastranova%2C+V&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=1991-07-01&rft.volume=33&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment. AN - 80701374; 1856880 AB - Several F1 mouse hybrids were used in a chronic bioassay to determine whether such an experimental design would provide greater statistical power than using only the B6C3F1 hybrid. For this purpose, the dose response of formation of hepatocellular and bladder tumors after 30 mo of feeding 2-acetylaminofluorene (2-AAF) in the diet was assessed in 4 F1 mouse hybrids, including the B6C3F1 hybrid. No strain background-related differences in frequency of bladder neoplasms between any F1 hybrids were detected. Bladder tumors occurred only at the highest 2-AAF dose in female mice. In males the lowest dose was already sufficient to induce bladder neoplasms with incidences of 25-48% adjusted for different nontumor mortality patterns across doses. No marked strain-related differences in hepatocellular tumor rates were apparent in either sex. Higher frequencies of hepatocellular neoplasms were observed among the untreated control males of the B6C3, AY, and CVA F1 hybrids than among the comparable females. Among treated mice, the lowest 2-AAF dose increased liver tumor incidence, more so among the females than among the males. The different background genomes resulted in somewhat different risk assessments for liver tumor formation in males due to differences in the time-to-tumor curves. Except for the much higher background liver tumor rate in the CVY mice, the adjusted liver tumor incidences were similar across the four hybrids. Hence, the levels of statistical significance obtained for dose-response trends and comparisons of treated and control groups were similar using 48 animals per dose groups with B6C3 mice, or combinations of 24 animals per dose from 2 genotypes, or 12 animals per dose from the 4 hybrid genotypes. Estimates of carcinogenic potency for bladder tumors were similar, within a factor of two, across the four hybrids. However, estimates of liver tumor potency across genotypes varied by a factor of two and six for females and males, respectively. Thus, the mean of cancer potency estimates across these genotypes would be more representative for mice than results from any single genotype. As in chronic carcinogenesis studies with other test agents, neoplasms developed in only a certain proportion, rather than in all, of the genetically identical animals exposed to a given dose of the toxicant for the same length of time under the same controlled environmental conditions. This phenotypic variability in toxic responses may reflect differential regulation of gene expression among the genetically identical test animals. JF - Journal of toxicology and environmental health AU - Wolff, G L AU - Gaylor, D W AU - Blackwell, B N AU - Moore, G E AD - National Center for Toxicological Research, Food and Drug Administration, U.S. Department of Health and Human Services, Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 327 EP - 348 VL - 33 IS - 3 SN - 0098-4108, 0098-4108 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Genotype KW - Animals KW - Sex Factors KW - Risk Factors KW - Mice KW - Species Specificity KW - Male KW - Female KW - Liver Neoplasms, Experimental -- genetics KW - 2-Acetylaminofluorene -- toxicity KW - Urinary Bladder Neoplasms -- genetics KW - Liver Neoplasms, Experimental -- chemically induced KW - Papilloma -- genetics KW - Papilloma -- chemically induced KW - Urinary Bladder Neoplasms -- chemically induced KW - Carcinoma -- genetics KW - Carcinoma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80701374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Bladder+and+liver+tumorigenesis+induced+by+2-acetylaminofluorene+in+different+F1+mouse+hybrids%3A+variation+within+genotypes+and+effects+of+using+more+than+one+genotype+on+risk+assessment.&rft.au=Wolff%2C+G+L%3BGaylor%2C+D+W%3BBlackwell%2C+B+N%3BMoore%2C+G+E&rft.aulast=Wolff&rft.aufirst=G&rft.date=1991-07-01&rft.volume=33&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenesis and DNA adduct formation by 1-nitropyrene in Chinese hamster ovary cells without exogenous metabolic activation. AN - 80690888; 1853350 AB - The direct-acting mutagenicity of 1-nitropyrene (1-NP), a tumorigenic environmental pollutant and model nitropolycyclic aromatic hydrocarbon, was studied in Chinese hamster ovary (CHO) cells. Previous reports indicated that 1-NP, a potent direct-acting mutagen in Salmonella typhimurium, was mutagenic in CHO cells only in the presence of an exogenous activation system. In this study, a DNA-repair-deficient CHO cell line, CHO-UV5, and the repair-proficient CHO-K1-BH4 cell line were used to measure the direct-acting mutagenicity of highly purified samples of 1-NP. Exposure of CHO-K1-BH4 cells for 5, 12, and 24 hr did not increase mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus (p greater than 0.1; paired t test; n = 5-6), while treatment of CHO-UV5 cells for 24 hr produced a statistically significant induction of mutants (22 +/- 6 mutants per 10(6) clonable cells vs a solvent control value of 9 +/- 3 per 10(6) cells; p less than 0.01; n = 6). 32P-Postlabeling analysis of the DNA adducts formed in CHO-UV5 cells following 1-NP exposure revealed the presence of a single major adduct. Based on its chromatographic properties, its sensitivity to nuclease P1 digestion, and its resistance to hydrazine treatment, the adduct appeared to be N-(deoxyguanosin-8-yl)-1-aminopyrene, which was presumably produced by nitroreduction of 1-NP to N-hydroxy-1-aminopyrene. These results suggest that the use of extended treatment times and DNA-repair-deficient cells may be required to assess adequately the mutagenicity of nitropolycyclic aromatic hydrocarbons in CHO cells. JF - Toxicology and applied pharmacology AU - Thornton-Manning, J R AU - Smith, B A AU - Beland, F A AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 538 EP - 546 VL - 109 IS - 3 SN - 0041-008X, 0041-008X KW - Pyrenes KW - 0 KW - DNA KW - 9007-49-2 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Ovary -- metabolism KW - Animals KW - Cricetulus KW - Cells, Cultured KW - Ovary -- drug effects KW - Autoradiography KW - Female KW - Cricetinae KW - Pyrenes -- toxicity KW - Mutagenesis -- drug effects KW - DNA Repair -- drug effects KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80690888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Mutagenesis+and+DNA+adduct+formation+by+1-nitropyrene+in+Chinese+hamster+ovary+cells+without+exogenous+metabolic+activation.&rft.au=Thornton-Manning%2C+J+R%3BSmith%2C+B+A%3BBeland%2C+F+A%3BHeflich%2C+R+H&rft.aulast=Thornton-Manning&rft.aufirst=J&rft.date=1991-07-01&rft.volume=109&rft.issue=3&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-21 N1 - Date created - 1991-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Target tissue specificity of retinoic acid-induced stress proteins and malformations in mice. AN - 72494326; 1957259 AB - Retinoic acid (RA) is teratogenic in rodents and also induces the synthesis of stress proteins in fetal mouse limb buds. To determine if the RA induction of stress proteins is target tissue specific, pregnant CD-1 mice were gavaged with 100 mg/kg RA on day 11 of gestation, and nuclei isolated from tissues susceptible to RA-induced malformations (target tissues) as well as nuclei isolated from nontarget tissues were examined for stress protein synthesis and malformations. Forelimb and hindlimb (target tissues), as well as heart and tail (nontarget tissues), were removed from embryos 2.5 hours after RA treatment (1.5 hr after [3H]leucine labeling). Cell nuclei were isolated, stained with a DNA specific fluorochrome, propidium iodide, and sorted from the G0 + G1 and G2 + M phases of the cell cycle. Forelimb and hindlimb target tissues showed the synthesis in these embryonic nuclear proteins of an 84,000 relative molecular mass (Mr) protein and a 90,000 Mr protein following RA treatment. Two 20,000-25,000 Mr stress proteins were also labeled both in forelimb and hindlimb. Forelimb and hindlimb from untreated dams showed no stress protein labeling. Neither heart nor tail, nontarget tissues, showed any stress protein labeling following RA treatment. Classical teratological evaluation of embryos treated on GD 11 and sacrificed on GD 17 showed that 100% of the fetuses had forelimb and/or hindlimb malformations, while no malformations were observed in either the heart or tail. Based on the correlation of teratological anomalies with the identification of stress proteins in target tissue only, we postulate that stress proteins may be involved in the teratogenic process. Further work is necessary to establish whether a causal relationship exists. JF - Teratology AU - Anson, J F AU - Laborde, J B AU - Pipkin, J L AU - Hinson, W G AU - Hansen, D K AU - Sheehan, D M AU - Young, J F AD - Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 19 EP - 28 VL - 44 IS - 1 SN - 0040-3709, 0040-3709 KW - Heat-Shock Proteins KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Mice KW - Bone and Bones -- abnormalities KW - Tretinoin -- toxicity KW - Heat-Shock Proteins -- biosynthesis KW - Abnormalities, Drug-Induced -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72494326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Target+tissue+specificity+of+retinoic+acid-induced+stress+proteins+and+malformations+in+mice.&rft.au=Anson%2C+J+F%3BLaborde%2C+J+B%3BPipkin%2C+J+L%3BHinson%2C+W+G%3BHansen%2C+D+K%3BSheehan%2C+D+M%3BYoung%2C+J+F&rft.aulast=Anson&rft.aufirst=J&rft.date=1991-07-01&rft.volume=44&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-30 N1 - Date created - 1991-12-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Teratology. 1992 Feb;45(2):121-4 [1615421] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638. AN - 72482171; 1950818 AB - In this study, we investigated the effect of ST638, a novel tyrosine kinase inhibitor, on TPA and ionomycin-stimulated PGE2 production after transfection of c-fms encoded CSF-1 receptor (CSF-1R) DNA (with or without transforming activity) into the myeloid progenitor cell line, 32D. ST638 inhibited prostaglandin E2 (PGE2) production induced after transfection of normal c-fms into 32D cell line, but failed to inhibit PGE2 production induced in 32D cells transformed with c-fms containing a point mutation at tyrosine 969 in the intracellular domain (substitution with phenylalanine) and at leucine 301 in the extracellular domain (substitution with serine). The selective effect on PGE2 production in normal c-fms-bearing cells by ST638 may indicate the presence of different induction pathways, one sensitive to ST638 and the other not. Alternatively, the phosphorylation site at tyr969 in c-fms may be a site of ST638 action, and upon its removal from the transforming c-fms, ST638 loses its inhibitory effect. JF - Agents and actions AU - Puri, J AU - Pierce, J H AU - Hoffman, T AD - Laboratory of Cell Biology, U.S. Food and Drug Administration, Bethesda, MD. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 314 EP - 317 VL - 33 IS - 3-4 SN - 0065-4299, 0065-4299 KW - Cinnamates KW - 0 KW - Indicators and Reagents KW - Interleukin-3 KW - Receptors, Colony-Stimulating Factor KW - Sulfides KW - ST 638 KW - 107761-24-0 KW - Arachidonic Acid KW - 27YG812J1I KW - Ionomycin KW - 56092-81-0 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phenotype KW - Transfection KW - Cells, Cultured KW - Humans KW - Interleukin-3 -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Ionomycin -- pharmacology KW - Arachidonic Acid -- metabolism KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Receptors, Colony-Stimulating Factor -- genetics KW - Dinoprostone -- biosynthesis KW - Cinnamates -- pharmacology KW - Sulfides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72482171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agents+and+actions&rft.atitle=Selective+inhibition+of+PGE2+production+in+cells+transfected+with+c-fms+encoded+CSF-1+receptor+genes+by+the+tyrosine+kinase+inhibitor%2C+ST638.&rft.au=Puri%2C+J%3BPierce%2C+J+H%3BHoffman%2C+T&rft.aulast=Puri&rft.aufirst=J&rft.date=1991-07-01&rft.volume=33&rft.issue=3-4&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Agents+and+actions&rft.issn=00654299&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-23 N1 - Date created - 1991-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Homosexual men who engage in high-risk sexual behavior. A multicenter comparison. AN - 72473888; 1948516 AB - To describe homosexual men who continue to engage in unprotected oral and anal sex, 601 men who attended three urban STD clinics and who had engaged in these behaviors with a male partner in the previous 4 months were interviewed regarding their sexual and drug-use behaviors. Although approximately one fourth of participants had engaged in 1 to 2 episodes of unprotected anal sex, more than 20% reported engaging in greater than 23 episodes. Higher frequency of anal sex was associated with lower condom use rates. Although 50% had primary relationships, less than 22% had sex with just one partner, and less than 10% were in relationships concordant for HIV-antibody status. Multiple regression analyses showed that number of drugs used each month, sex in a steady relationship, and Hispanic ethnicity were the most consistent predictors of risk behavior across sites. Careful evaluation of the diverse nature and characteristics of these men is essential to target risk-reduction programs for this population. JF - Sexually transmitted diseases AU - Doll, L S AU - Byers, R H AU - Bolan, G AU - Douglas, J M AU - Moss, P M AU - Weller, P D AU - Joy, D AU - Bartholow, B N AU - Harrison, J S AD - Division of HIV/AIDS, Center for Infectious Diseases, Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, Georgia 30333. PY - 1991 SP - 170 EP - 175 VL - 18 IS - 3 SN - 0148-5717, 0148-5717 KW - HIV Antibodies KW - 0 KW - Index Medicus KW - Population KW - AIDS/HIV KW - United States KW - Family Characteristics KW - Measurement KW - Laboratory Examinations And Diagnoses KW - Immunologic Factors KW - Barrier Methods KW - Research Methodology KW - Sex Behavior KW - Physiology KW - Antibodies--analysis KW - Contraceptive Methods KW - Developed Countries KW - Population At Risk KW - Population Characteristics KW - Homosexuals--men KW - Sampling Studies KW - Hispanics--men KW - Demographic Factors KW - Family Planning KW - Urban Population KW - North America KW - Americas KW - Surveys KW - Studies KW - Immunity KW - Cross Sectional Analysis KW - Alcohol Drinking KW - Couples KW - Condom KW - Northern America KW - Contraception KW - Behavior KW - Ethnic Groups KW - Risk Factors KW - Examinations And Diagnoses KW - Family And Household KW - Drug Usage KW - Cultural Background KW - Biology KW - Regression Analysis KW - Humans KW - African Americans KW - Aged KW - Chicago KW - San Francisco KW - HIV Antibodies -- blood KW - Hispanic Americans KW - Bisexuality KW - Adult KW - Middle Aged KW - Colorado KW - Male KW - Substance-Related Disorders -- epidemiology KW - Contraceptive Devices, Male KW - Sexual Behavior KW - Health Behavior KW - Homosexuality KW - Sexually Transmitted Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72473888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+diseases&rft.atitle=Homosexual+men+who+engage+in+high-risk+sexual+behavior.+A+multicenter+comparison.&rft.au=Doll%2C+L+S%3BByers%2C+R+H%3BBolan%2C+G%3BDouglas%2C+J+M%3BMoss%2C+P+M%3BWeller%2C+P+D%3BJoy%2C+D%3BBartholow%2C+B+N%3BHarrison%2C+J+S&rft.aulast=Doll&rft.aufirst=L&rft.date=1991-07-01&rft.volume=18&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+diseases&rft.issn=01485717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-02 N1 - Date created - 1991-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heat and cold in farm workers. AN - 72470342; 1948525 JF - Occupational medicine (Philadelphia, Pa.) AU - Brown, W D AD - Federal Employee Occupational Health, U.S. Public Health Service, Seattle, WA 98121-2500. PY - 1991 SP - 371 EP - 389 VL - 6 IS - 3 SN - 0885-114X, 0885-114X KW - Index Medicus KW - United States KW - Heart Rate KW - Primary Prevention KW - Body Temperature KW - Maximum Allowable Concentration KW - Humans KW - Body Temperature Regulation -- physiology KW - Acclimatization -- physiology KW - United States Occupational Safety and Health Administration KW - Monitoring, Physiologic KW - Hypothermia -- prevention & control KW - Agricultural Workers' Diseases -- metabolism KW - Hypothermia -- metabolism KW - Agricultural Workers' Diseases -- prevention & control KW - Heat Exhaustion -- metabolism KW - Agricultural Workers' Diseases -- etiology KW - Heat Exhaustion -- prevention & control KW - Hypothermia -- etiology KW - Heat Exhaustion -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72470342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Heat+and+cold+in+farm+workers.&rft.au=Brown%2C+W+D&rft.aulast=Brown&rft.aufirst=W&rft.date=1991-07-01&rft.volume=6&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-04 N1 - Date created - 1991-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of magnesium on the growth and cell cycle of transformed and non-transformed epithelial rat liver cells in vitro. AN - 72445468; 1933512 AB - The effects of magnesium (Mg) restriction on cell growth and the cell cycle were determined in transformed (TRL-8) and non-transformed (TRL-12-15) epithelial-like rat liver cells. Cells were cultured in RPMI 1640 medium in which the Mg concentration was reduced to 0.5, 0.1, and 0 x the concentration in the regular RPMI 1640 media (100mg/l). Cell growth in the transformed cells was not influenced by the Mg restriction as greatly as in the non-transformed cell line. Transit through the cell cycle also exhibited an independence of the Mg in the medium in the transformed cells. When transformed cells were grown for two generations in Mg-limited medium, the growth rate slowed to a rate similar to that demonstrated by the non-transformed cells. Analysis by flow cytometry showed that transit through the cell cycle was minimally slowed in Mg deficient transformed cells; however, transit through the G1 and S phases in the non-transformed cells was slowed. The TRL-8 cells in Mg-limited medium resulted in fewer nuclei in G1 with subsequent increases in the percentages of S-phase nuclei. The TRL 12-15 cells reacted oppositely with the number of G1 nuclei increased and the number of S-phase nuclei decreased. In respect to growth, these results show that epithelial cells respond in a similar manner to Mg-limitation as do fibroblast cells. The transformed cells exhibited a level of independence from Mg in respect to growth, reproduction, and cell-cycle kinetics. JF - Cell biology and toxicology AU - Littlefield, N A AU - Hass, B S AU - McGarrity, L J AU - Morris, S M AD - U.S. Public Health Service, Food and Drug Administration National Center for Toxicological Research Jefferson, Arkansas 72079. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 203 EP - 214 VL - 7 IS - 3 SN - 0742-2091, 0742-2091 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Rats KW - Animals KW - Epithelial Cells KW - Flow Cytometry KW - Cell Line, Transformed KW - Epithelium -- drug effects KW - Cell Line KW - Liver -- cytology KW - Liver -- drug effects KW - Magnesium -- toxicity KW - Cell Division -- drug effects KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72445468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Effect+of+magnesium+on+the+growth+and+cell+cycle+of+transformed+and+non-transformed+epithelial+rat+liver+cells+in+vitro.&rft.au=Littlefield%2C+N+A%3BHass%2C+B+S%3BMcGarrity%2C+L+J%3BMorris%2C+S+M&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1991-07-01&rft.volume=7&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-09 N1 - Date created - 1991-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative study of intracellular glutathione content in rat lymphocyte cultures treated with 2-mercaptoethanol and interleukin-2. AN - 72445429; 1933513 AB - The level of intracellular glutathione (GSH) in mitogen-stimulated mouse lymphocytes is increased in the presence of 2-mercaptoethanol (2-ME), an enhancer of lymphocyte activation and proliferation. Since proliferation of lymphocytes in response to mitogens involves direct activation by a mitogen followed by continued proliferation in response to interleukin-2 (IL-2), we have investigated the effect of 2-ME and exogenous IL-2 on the GSH content and cell proliferation of rat lymphocytes stimulated with phytohemagglutinin (PHA). PHA stimulation increased both GSH content and the magnitude of the proliferative response, as measured by thymidine incorporation into cellular DNA. However, incubation of stimulated lymphocytes with 2-ME or IL-2 for 72 hr produced a significant further elevation of GSH levels and thymidine incorporation. 2-ME also increased the GSH content in unstimulated cultures, but it had little effect on thymidine incorporation. IL-2 increased GSH content and decreased thymidine incorporation in unstimulated lymphocytes. Exposure of cells to DL-buthionine-(S,R)-sulfoximine (BSO), an inhibitor of GSH biosynthesis, significantly depleted GSH and lowered the proliferative response, suggesting a crucial role of de novo GSH synthesis for lymphocyte activation. The data suggest that both 2-ME and IL-2 promote lymphocyte proliferation, although the mechanisms by which intracellular GSH levels are increased by the agents are apparently different. JF - Cell biology and toxicology AU - Aidoo, A AU - Lyn-Cook, L E AU - Morris, S M AU - Kodell, R L AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration National Center for Toxicological Research Jefferson, Arkansas 72079-9502. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 215 EP - 227 VL - 7 IS - 3 SN - 0742-2091, 0742-2091 KW - Interleukin-2 KW - 0 KW - Methionine Sulfoximine KW - 1982-67-8 KW - Buthionine Sulfoximine KW - 5072-26-4 KW - Mercaptoethanol KW - 60-24-2 KW - DNA KW - 9007-49-2 KW - Glutathione KW - GAN16C9B8O KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Methionine Sulfoximine -- toxicity KW - Methionine Sulfoximine -- analogs & derivatives KW - DNA -- biosynthesis KW - Male KW - Lymphocytes -- chemistry KW - Mercaptoethanol -- toxicity KW - Glutathione -- analysis KW - Interleukin-2 -- toxicity KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72445429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Comparative+study+of+intracellular+glutathione+content+in+rat+lymphocyte+cultures+treated+with+2-mercaptoethanol+and+interleukin-2.&rft.au=Aidoo%2C+A%3BLyn-Cook%2C+L+E%3BMorris%2C+S+M%3BKodell%2C+R+L%3BCasciano%2C+D+A&rft.aulast=Aidoo&rft.aufirst=A&rft.date=1991-07-01&rft.volume=7&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-09 N1 - Date created - 1991-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of cyanide poisoning. AN - 72148689; 1922842 AB - The object of this study was to evaluate the effectiveness of five regimens in treating cyanide poisoning. A series of anesthetized adult beagle dogs were instrumented to record hemodynamic and respiratory function and given 2.5 mg/kg sodium cyanide intravenously. The 10 control animals given only cyanide died at from 5 to 7 minutes. Therapy, as described below, was given to other groups at from 2 to 3 minutes following the cyanide administration. Artificial respiration did not alter the lethal effects of cyanide nor prolong survival time in any of the 10 animals. Amyl nitrite given by inhalation or by the intravenous route allowed survival of all 15 animals. Sodium nitrite (20 mg/kg), dimethylaminophenol (DMAP) (5 mg/kg), and hydroxylamine hydrochloride (5 mg/kg) given intravenously with no artificial ventilation also allowed for 100% survival (15 animals). Amyl nitrite, sodium nitrite, and sodium thiosulfate were ineffective when given intramuscularly (I.M.) (0 of 12 dogs); however, I.M. DMAP (5 mg/kg) and I.M. hydroxylamine hydrochloride (50 mg/kg) increased heart rate and blood pressure and restored spontaneous breathing. All 15 animals treated with I.M. doses of either of these drugs survived the lethal dose of cyanide. Results of these studies indicate that intravenous sodium nitrite, DMAP, and hydroxylamine hydrochloride, and amyl nitrite by inhalation, are all effective in reversing the lethal effects of cyanide poisoning. Only DMAP and hydroxylamine hydrochloride are effective when given by the intramuscular route. These results provide data to support an approach to therapy that is more practical and applicable where expert medical care may not be available following cyanide exposure. JF - Military medicine AU - Vick, J A AU - Froehlich, H AD - Food and Drug Administration, Washington, DC 20204. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 330 EP - 339 VL - 156 IS - 7 SN - 0026-4075, 0026-4075 KW - Cyanides KW - 0 KW - Index Medicus KW - Animals KW - Poisoning -- physiopathology KW - Dogs KW - Poisoning -- drug therapy KW - Cyanides -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72148689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Treatment+of+cyanide+poisoning.&rft.au=Vick%2C+J+A%3BFroehlich%2C+H&rft.aulast=Vick&rft.aufirst=J&rft.date=1991-07-01&rft.volume=156&rft.issue=7&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-20 N1 - Date created - 1991-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhanced supercritical fluid carbon dioxide extraction of pesticides from foods using pelletized diatomaceous earth. AN - 72138316; 1917813 AB - Supercritical fluid carbon dioxide (SC-CO2), when used with an extraction enhancer, comprises a supercritical fluid extraction (SFE) system for extraction of pesticides and matrix components from fatty and nonfatty foods. After being mixed with the enhancer, samples ranging from 95% water to pure lipophilic oils can be extracted efficiently with SC-CO2. This extraction technique yields analyte recoveries in excess of 85% for over 30 types of pesticides at incurred levels ranging from 0.005 to 2 ppm in such diverse matrixes as carrots, lettuce, peanut butter, hamburger, and fortified butter fat and fortified potatoes. SC-CO2 provides a solvent medium that is nontoxic, nonflammable, and inexpensive while also eliminating the use and disposal of potentially carcinogenic organic solvents. JF - Journal - Association of Official Analytical Chemists AU - Hopper, M L AU - King, J W AD - Food and Drug Administration, Total Diet Research Center, Kansas City, MO 64106. PY - 1991 SP - 661 EP - 666 VL - 74 IS - 4 SN - 0004-5756, 0004-5756 KW - Lipids KW - 0 KW - Pesticides KW - Water KW - 059QF0KO0R KW - Carbon Dioxide KW - 142M471B3J KW - Diatomaceous Earth KW - 61790-53-2 KW - Butter KW - 8029-34-3 KW - Index Medicus KW - Butter -- analysis KW - Meat -- analysis KW - Lipids -- analysis KW - Pesticides -- analysis KW - Food Analysis -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72138316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Enhanced+supercritical+fluid+carbon+dioxide+extraction+of+pesticides+from+foods+using+pelletized+diatomaceous+earth.&rft.au=Hopper%2C+M+L%3BKing%2C+J+W&rft.aulast=Hopper&rft.aufirst=M&rft.date=1991-07-01&rft.volume=74&rft.issue=4&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fumigation trends, fumigant analysis, and findings. AN - 72137982; 1917802 JF - Journal - Association of Official Analytical Chemists AU - Daft, J L AD - Food and Drug Administration, U.S. Department of Health and Human Service, Kansas City, MO 64106. PY - 1991 SP - 575 EP - 576 VL - 74 IS - 4 SN - 0004-5756, 0004-5756 KW - Index Medicus KW - Food Analysis -- methods KW - Food Contamination -- analysis KW - Fumigation -- methods KW - Fumigation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72137982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Fumigation+trends%2C+fumigant+analysis%2C+and+findings.&rft.au=Daft%2C+J+L&rft.aulast=Daft&rft.aufirst=J&rft.date=1991-07-01&rft.volume=74&rft.issue=4&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lipid globule staining to aid in differentiating Bacillus species. AN - 72136569; 1717433 AB - The use of the lipid globule stain to aid in differentiating the Bacillus cereus group (i.e., B. cereus, B. cereus var. mycoides, and B. thuringiensis) from other Bacillus species was investigated. Smears from colonies grown on suitable agar were made on precleaned slides, stained, and examined microscopically for characteristic deep blue lipid globules. The study included a total of 649 cultures of Bacillus species plus 143 incompletely characterized Bacillus isolates from food. Only B. cereus, B. cereus var. mycoides, B. thuringiensis, B. megaterium, and B. sphaericus were consistently positive for lipid globules, although at times, a few cells of B. aneurinolyticus and B. thiaminolyticus were also positive. The lipid globule stain procedure is of value in differentiating Bacillus species, especially when performed by an experienced analyst and used in conjunction with tests for cell and spore morphology. JF - Journal - Association of Official Analytical Chemists AU - Harmon, S M AU - Kautter, D A AU - Lancette, G AD - Food and Drug Administration, Division of Microbiology, Washington, DC 20204. PY - 1991 SP - 649 EP - 651 VL - 74 IS - 4 SN - 0004-5756, 0004-5756 KW - Index Medicus KW - Bacillus cereus -- classification KW - Food Microbiology KW - Staining and Labeling -- methods KW - Bacillus cereus -- metabolism KW - Bacillus -- metabolism KW - Bacillus -- classification KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72136569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Lipid+globule+staining+to+aid+in+differentiating+Bacillus+species.&rft.au=Harmon%2C+S+M%3BKautter%2C+D+A%3BLancette%2C+G&rft.aulast=Harmon&rft.aufirst=S&rft.date=1991-07-01&rft.volume=74&rft.issue=4&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Results from the American Society for Gastrointestinal Endoscopy/U.S. Food and Drug Administration collaborative study on complication rates and drug use during gastrointestinal endoscopy. AN - 72127858; 1833259 AB - We used data from the American Society for Gastrointestinal Endoscopy's computer-based management system to compare the rates of serious cardiorespiratory complications and death associated with the use of midazolam and diazepam. Data were analyzed from 21,011 procedures. Midazolam was used in 15,061 of these procedures, diazepam in 4,302, and neither in 1,648. We assessed benzodiazepine dose, concomitant drug administration, type of procedure, and selected patient characteristics in each of these three groups. No significant difference between these three groups were noted other than the fact that certain clinical centers tended to exclusively use midazolam, whereas others used both benzodiazepines. Reports of serious cardiorespiratory complications and death were uncommon, occurring in 5.4 and 0.3 per thousand procedures, respectively. Midazolam did not seem to place patients in this sample at greater risk for cardiorespiratory complications than diazepam. Concomitant use of narcotics and urgent and emergent procedures, however, did increase the risk of serious cardiorespiratory events. JF - Gastrointestinal endoscopy AU - Arrowsmith, J B AU - Gerstman, B B AU - Fleischer, D E AU - Benjamin, S B AD - U.S. Food and Drug Administration, Rockville, MD. PY - 1991 SP - 421 EP - 427 VL - 37 IS - 4 SN - 0016-5107, 0016-5107 KW - Diazepam KW - Q3JTX2Q7TU KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Injections, Intravenous KW - Heart Diseases -- chemically induced KW - Humans KW - Retrospective Studies KW - Conscious Sedation -- adverse effects KW - Respiration Disorders -- etiology KW - Aged KW - Respiration Disorders -- chemically induced KW - Laparoscopy -- adverse effects KW - Cholangiopancreatography, Endoscopic Retrograde -- adverse effects KW - Middle Aged KW - Heart Diseases -- etiology KW - Female KW - Male KW - Diazepam -- administration & dosage KW - Endoscopy, Gastrointestinal -- adverse effects KW - Midazolam -- administration & dosage KW - Diazepam -- adverse effects KW - Midazolam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72127858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastrointestinal+endoscopy&rft.atitle=Results+from+the+American+Society+for+Gastrointestinal+Endoscopy%2FU.S.+Food+and+Drug+Administration+collaborative+study+on+complication+rates+and+drug+use+during+gastrointestinal+endoscopy.&rft.au=Arrowsmith%2C+J+B%3BGerstman%2C+B+B%3BFleischer%2C+D+E%3BBenjamin%2C+S+B&rft.aulast=Arrowsmith&rft.aufirst=J&rft.date=1991-07-01&rft.volume=37&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Gastrointestinal+endoscopy&rft.issn=00165107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Lead exposure from conventional and cottage lead smelting in Jamaica. AN - 72118408; 1898119 AB - A survey was conducted to determine the distribution and determinants of environmental and blood lead levels near a conventional and several cottage lead smelters and to assess the relationship between environmental and blood lead levels in a tropical, developing-country setting. Fifty-eight households were studied in the Red Pond community, the site of the established smelter and several backyard smelters, and 21 households were studied in the adjacent, upwind Ebony Vale community in Saint Catherine Parish, Jamaica. Households were investigated, using questionnaires, soil and housedust lead measurements, and blood lead (PbB) measurements from 372 residents. Soil lead levels in Red Pond exceeded 500 parts per million (ppm) at 24% of households (maximum--18,600 ppm), compared to 0% in Ebony Vale (maximum 150 ppm). Geometric mean PbB in Red Pond, where 44% of children less than 6 years of age had PbB levels greater than or equal to 25 micrograms per deciliter (micrograms/dL), was more than twice that Ebony Vale in all age groups (p less than 0.0005). Within Red Pond, proximity to backyard smelters and to the conventional smelter were independent predictors of soil lead (p less than 0.05). Soil lead was the strongest predictor of PbB among Red Pond subjects under 12 years of age. The blood lead--soil lead relationship in children differed from that reported in developed countries; blood lead levels were higher than expected for the household-specific soil lead levels that were observed.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Archives of environmental contamination and toxicology AU - Matte, T D AU - Figueroa, J P AU - Ostrowski, S AU - Burr, G AU - Jackson-Hunt, L AU - Baker, E L AD - Office of the Director, National Institute for Occupational Safety and Health Centers for Disease Control, Atlanta, Georgia 30333. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 65 EP - 71 VL - 21 IS - 1 SN - 0090-4341, 0090-4341 KW - Dust KW - 0 KW - Soil KW - Soil Pollutants KW - Lead KW - 2P299V784P KW - Index Medicus KW - Infant KW - Humans KW - Developing Countries KW - Child KW - Jamaica KW - Tropical Climate KW - Child, Preschool KW - Dust -- analysis KW - Soil -- analysis KW - Soil Pollutants -- blood KW - Lead -- analysis KW - Metallurgy KW - Lead -- blood KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72118408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+contamination+and+toxicology&rft.atitle=Lead+exposure+from+conventional+and+cottage+lead+smelting+in+Jamaica.&rft.au=Matte%2C+T+D%3BFigueroa%2C+J+P%3BOstrowski%2C+S%3BBurr%2C+G%3BJackson-Hunt%2C+L%3BBaker%2C+E+L&rft.aulast=Matte&rft.aufirst=T&rft.date=1991-07-01&rft.volume=21&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+contamination+and+toxicology&rft.issn=00904341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-23 N1 - Date created - 1991-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Statistical model in tests for eye irritants. AN - 72101705; 1894212 AB - A test used to classify substances for eye irritancy, as required by the Consumer Product Safety Commission, is performed on 1-3 groups of 6 albino rabbits in a sequential manner. When the statistical implications of the test are realized, it is possible for a substance to be classified as an irritant with fewer reactions than the number required for it to be classified as not an irritant. A procedure is given for correcting the inconsistency in the current test, and an alternative test, which considerably reduces the number of animals required, is proposed. Probability models and expected sample size calculations have been derived. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Roberts, C D AD - Division of Mathematics, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 463 EP - 468 VL - 29 IS - 7 SN - 0278-6915, 0278-6915 KW - Irritants KW - 0 KW - Index Medicus KW - Probability KW - Animals KW - Rabbits KW - Animal Testing Alternatives KW - Animal Welfare KW - Models, Statistical KW - Eye -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72101705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Statistical+model+in+tests+for+eye+irritants.&rft.au=Roberts%2C+C+D&rft.aulast=Roberts&rft.aufirst=C&rft.date=1991-07-01&rft.volume=29&rft.issue=7&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-22 N1 - Date created - 1991-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of dietary soya bean trypsin inhibitor concentrate on initiation and growth of putative preneoplastic lesions in the pancreas of the rat. AN - 72099020; 1894210 AB - Two studies evaluated the effects of soya bean trypsin inhibitor concentrate (STIC) on early stages of pancreatic carcinogenesis in Wistar rats. In experiment 1, the effects of a 3-month administration of diets containing 3.7% STIC were compared with the effects of administration of diets containing 20% corn oil, in rats pretreated with a single azaserine injection sufficient to initiate putative preneoplastic atypical acinar cell foci. Experiment 2 investigated the capacity of STIC to initiate pancreatic carcinogenesis. Diets containing 3.7% STIC were fed for 4 wk, then diets containing either 5 or 20% corn oil were fed for 3 months. Pancreases were quantitatively evaluated for foci. All groups of azaserine-initiated rats had large numbers of atypical acinar cell foci per cm3 of pancreas. Of these, the group fed 3.7% STIC had pancreatic foci that occupied a significantly greater (P less than 0.01) percentage volume of pancreas than did groups fed 20% corn oil or control diets, which contained 5% corn oil and no added trypsin inhibitor. Very few or no foci were observed in all other groups of either experiment 1 or 2. STIC had a much greater effect on the growth of azaserine-induced lesions than did corn oil. STIC alone did not appear to initiate pancreatic lesions. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Myers, B A AU - Hathcock, J AU - Shiekh, N AU - Roebuck, B D AD - Division of Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 437 EP - 443 VL - 29 IS - 7 SN - 0278-6915, 0278-6915 KW - Trypsin Inhibitors KW - 0 KW - Corn Oil KW - 8001-30-7 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Pancreas -- pathology KW - Eating -- drug effects KW - Animals KW - Body Weight -- drug effects KW - Pancreas -- growth & development KW - Pancreas -- drug effects KW - Corn Oil -- administration & dosage KW - Male KW - Organ Size -- drug effects KW - Precancerous Conditions -- chemically induced KW - Pancreatic Neoplasms -- chemically induced KW - Trypsin Inhibitors -- toxicity KW - Soybeans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72099020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Effects+of+dietary+soya+bean+trypsin+inhibitor+concentrate+on+initiation+and+growth+of+putative+preneoplastic+lesions+in+the+pancreas+of+the+rat.&rft.au=Myers%2C+B+A%3BHathcock%2C+J%3BShiekh%2C+N%3BRoebuck%2C+B+D&rft.aulast=Myers&rft.aufirst=B&rft.date=1991-07-01&rft.volume=29&rft.issue=7&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-22 N1 - Date created - 1991-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Followup study of possible HIV seropositivity among abusers of parenteral drugs in 1971-72. AN - 72051691; 1908596 AB - Serum specimens obtained from a nationwide sample of parenteral drug abusers (PDAs) during the period 1971-72 had previously been screened for human immunodeficiency virus (HIV) antibodies. Some specimens were considered to be positive to both ELISA and Western blot (WB) analysis. These findings have been a topic of controversy, since HIV was not thought to have penetrated at-risk populations at such an early date. This study was a followup of those PDAs with apparent seropositivity to WB analysis. Of 10 persons followed, only one death (in 1985) was documented, and postmortem findings were inconsistent with HIV infection. Eight of the remaining PDAs were traced and found to be alive and well in 1989. Fresh specimens were obtained from the two persons with the strongest 1971-72 WB staining and were found to be both ELISA and WB negative on retesting. Their T-cell parameters were within normal limits. We concluded that the earlier WB results were most likely false positives and that definitive evidence of HIV infection in the U.S. addict population as early as 1971-72 is still lacking. JF - Public health reports (Washington, D.C. : 1974) AU - Lange, W R AU - Ball, J C AU - Adler, W H AU - Brown, E AU - Pyle, R AU - Hoffman, W AU - Dax, E M AD - Public Health Service, National Institute on Drug Abuse's Addiction Research Center, Baltimore, MD 21224. PY - 1991 SP - 451 EP - 455 VL - 106 IS - 4 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Mortality KW - Blotting, Western KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Follow-Up Studies KW - T-Lymphocyte Subsets -- chemistry KW - Male KW - Female KW - Cross Reactions KW - Population Surveillance KW - Kentucky -- epidemiology KW - False Positive Reactions KW - Substance Abuse, Intravenous -- complications KW - HIV Seropositivity -- immunology KW - HIV Seropositivity -- epidemiology KW - HIV Seropositivity -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72051691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Followup+study+of+possible+HIV+seropositivity+among+abusers+of+parenteral+drugs+in+1971-72.&rft.au=Lange%2C+W+R%3BBall%2C+J+C%3BAdler%2C+W+H%3BBrown%2C+E%3BPyle%2C+R%3BHoffman%2C+W%3BDax%2C+E+M&rft.aulast=Lange&rft.aufirst=W&rft.date=1991-07-01&rft.volume=106&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-20 N1 - Date created - 1991-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Transfusion. 1988 Sep-Oct;28(5):412-8 [3420668] JAMA. 1984 Sep 7;252(9):1152-9 [6471338] Int J Addict. 1989 Jul;24(7):609-26 [2599682] Rev Infect Dis. 1987 Nov-Dec;9(6):1102-8 [3321360] Ann Intern Med. 1985 Nov;103(5):755-9 [4051350] N Engl J Med. 1986 May 22;314(21):1387-8 [3010112] J Infect Dis. 1986 Apr;153(4):736-42 [3005434] Anal Biochem. 1988 May 15;171(1):1-32 [3044183] Ann Intern Med. 1988 Jun;108(6):785-90 [3285743] Mayo Clin Proc. 1989 Oct;64(10):1226-34 [2593713] South Med J. 1989 Sep;82(9):1075-8 [2772675] Ann Intern Med. 1987 May;106(5):671-6 [3551711] Am J Med. 1984 Mar;76(3):493-500 [6322585] J Infect Dis. 1983 Aug;148(2):339-45 [6604115] Clin Exp Immunol. 1983 Aug;53(2):465-72 [6224612] Immunol Commun. 1983;12(2):223-237 [6603416] JAMA. 1988 Oct 14;260(14):2085-7 [3418874] N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - AIDS in U.S. hospitals, 1986-1987: a national perspective T2 - AHCPR pubn. no. 91-0015 Hospital studies program research note 15 AN - 59576677; 1991-1509670 AB - Examines inpatient care based on individual discharges. Profiles variations across geographic regions of the US in hospital resource use and financing, as well as patient characteristics, such as severity of illness, that contribute to variations in resource use. JF - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, July 1991. 21 pp. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 21 PB - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - Hospitals -- United States -- Statistics KW - United States -- Medical sector KW - Terminally ill -- Care and treatment KW - Acquired immune deficiency syndrome -- United States -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59576677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=AIDS+in+U.S.+hospitals%2C+1986-1987%3A+a+national+perspective&rft.title=AIDS+in+U.S.+hospitals%2C+1986-1987%3A+a+national+perspective&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 N1 - Document feature - bibl(s), table(s), chart(s), map(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct. AN - 80626226; 2052611 AB - The prevalence of covalent modifications to DNA (carcinogen-DNA adducts) in 42 human urinary bladder biopsy samples was investigated by 32P-postlabeling methods, with enhancement by both nuclease P1 treatment and 1-butanol extraction. Total mean carcinogen-DNA adduct levels and the mean levels of several specific adducts were significantly elevated in DNA samples of 13 current smokers, as opposed to 9 never smokers or 20 ex-smokers (5 years abstinence). There was no significant difference between the latter two groups. Several DNA adducts enhanced by nuclease P1 treatment were chromatographically similar to putative hydrocarbon DNA adducts reported earlier for placenta and lung DNA samples obtained from cigarette smokers. Putative aromatic amine adducts were detected by 1-butanol extraction that were not present when the samples were treated with nuclease P1. One of these displayed chromatographic behavior identical to the predominant adduct induced by the human urinary bladder carcinogen, 4-aminobiphenyl, which is present in cigarette smoke. This adduct comigrated in several thin-layer chromatographic systems with a synthetic N-(deoxyguanosin-8-yl)-4-amino[2,2'-3H]biphenyl-3',5'-bisphosphate marker. Moreover, when this adduct was eluted from the thin-layer chromatograms of several individuals and injected onto an HPLC system, the 32P from the human bladder DNA samples coeluted in the same fraction as the tritiated synthetic N-(deoxyguanosin-8-yl)-4-aminobiphenyl marker. These data reinforce an association between cigarette smoking and DNA damage and suggest a molecular basis for the initiation of human urinary bladder cancer by cigarette smoke. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Talaska, G AU - al-Juburi, A Z AU - Kadlubar, F F AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/06/15/ PY - 1991 DA - 1991 Jun 15 SP - 5350 EP - 5354 VL - 88 IS - 12 SN - 0027-8424, 0027-8424 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - N-(deoxyguanosin-8-yl)-4-aminobiphenyl KW - 86408-34-6 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Chromatography, Thin Layer KW - Autoradiography KW - Male KW - Chromatography, High Pressure Liquid KW - Smoking -- urine KW - Aminobiphenyl Compounds -- chemistry KW - DNA Damage KW - Urinary Bladder -- chemistry KW - Deoxyguanosine -- chemistry KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80626226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Smoking+related+carcinogen-DNA+adducts+in+biopsy+samples+of+human+urinary+bladder%3A+identification+of+N-%28deoxyguanosin-8-yl%29-4-aminobiphenyl+as+a+major+adduct.&rft.au=Talaska%2C+G%3Bal-Juburi%2C+A+Z%3BKadlubar%2C+F+F&rft.aulast=Talaska&rft.aufirst=G&rft.date=1991-06-15&rft.volume=88&rft.issue=12&rft.spage=5350&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-19 N1 - Date created - 1991-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1981 Oct;78(10):6126-9 [7031643] Prog Clin Biol Res. 1990;340B:107-14 [2392442] Carcinogenesis. 1983;4(3):335-8 [6831638] Proc Natl Acad Sci U S A. 1984 Nov;81(22):6943-7 [6594673] Appl Environ Microbiol. 1985 Jul;50(1):10-5 [4026284] Cancer Res. 1985 Nov;45(11 Pt 2):5656-62 [4053037] Science. 1986 Jan 3;231(4733):54-7 [3941892] Cancer Res. 1986 Jun;46(6):3046-54 [3698023] Carcinogenesis. 1986 Sep;7(9):1543-51 [3017601] Carcinogenesis. 1986 Sep;7(9):1615-7 [3742734] Cancer Res. 1987 Jan 15;47(2):602-8 [3791245] Carcinogenesis. 1987 Apr;8(4):515-20 [3549038] Biochemistry. 1987 Jun 2;26(11):3072-81 [3300770] Carcinogenesis. 1987 Dec;8(12):1899-905 [3677313] Carcinogenesis. 1988 Sep;9(9):1687-93 [3409474] Acta Oncol. 1988;27(4):323-7 [3202992] Nature. 1988 Dec 22-29;336(6201):790-2 [3205307] Mutat Res. 1989 Mar;219(2):121-33 [2927417] Cancer Lett. 1989 Apr;45(1):7-12 [2540901] Am J Public Health. 1989 Oct;79(10):1381-4 [2782507] Proc Natl Acad Sci U S A. 1989 Oct;86(20):7696-700 [2813353] Carcinogenesis. 1990 Feb;11(2):205-11 [2105856] Carcinogenesis. 1990 Apr;11(4):639-46 [2323002] Int J Cancer. 1990 Apr 15;45(4):673-8 [2323844] Cancer Res. 1990 May 15;50(10):3002-4 [2334904] Carcinogenesis. 1982;3(9):1081-92 [7139866] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei. AN - 80615045; 2049786 AB - The extent of lipid peroxidation and DNA damage induced by quercetin were studied under aerobic conditions in isolated rat-liver nuclei. The effects of iron and copper ions on these two toxic oxidative processes were also investigated. Quercetin induced significant (P less than 0.05) concentration-dependent nuclear lipid peroxidation concurrent with DNA degradation; these effects were enhanced by iron and copper ions. The results suggest that the reactive oxygen species generated by quercetin autoxidation, catalyzed by iron and copper ions, are responsible for the concurrent lipid peroxidation and DNA damage in isolated rat-liver nuclei. JF - Cancer letters AU - Sahu, S C AU - Washington, M C AD - Molecular Toxicology Laboratory, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/06/14/ PY - 1991 DA - 1991 Jun 14 SP - 75 EP - 79 VL - 58 IS - 1-2 SN - 0304-3835, 0304-3835 KW - Carcinogens KW - 0 KW - Free Radicals KW - Copper KW - 789U1901C5 KW - Quercetin KW - 9IKM0I5T1E KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Iron -- pharmacology KW - Cell Nucleus -- metabolism KW - Cell Nucleus -- drug effects KW - Diet KW - Copper -- pharmacology KW - Male KW - Quercetin -- administration & dosage KW - Liver -- drug effects KW - DNA Damage KW - Liver -- metabolism KW - Lipid Peroxidation KW - Quercetin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80615045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Quercetin-induced+lipid+peroxidation+and+DNA+damage+in+isolated+rat-liver+nuclei.&rft.au=Sahu%2C+S+C%3BWashington%2C+M+C&rft.aulast=Sahu&rft.aufirst=S&rft.date=1991-06-14&rft.volume=58&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-24 N1 - Date created - 1991-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Assistant Secretary for Health, US Public Health Service. AN - 80571960; 2033755 JF - JAMA AU - Mason, J O AD - Public Health Service, Washington, DC 20201. Y1 - 1991/06/12/ PY - 1991 DA - 1991 Jun 12 SP - 2939 VL - 265 IS - 22 SN - 0098-7484, 0098-7484 KW - Fluorides KW - Q80VPU408O KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Public Health Service KW - Fluoridation KW - Humans KW - Child KW - Fluorides -- adverse effects KW - Fluorosis, Dental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80571960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Assistant+Secretary+for+Health%2C+US+Public+Health+Service.&rft.au=Mason%2C+J+O&rft.aulast=Mason&rft.aufirst=J&rft.date=1991-06-12&rft.volume=265&rft.issue=22&rft.spage=2939&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-27 N1 - Date created - 1991-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Standardized tests and measures for assessing low-back pain in the occupational setting. A developmental model. AN - 80716828; 1830696 JF - Spine AU - Nelson, R M AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 679 EP - 681 VL - 16 IS - 6 SN - 0362-2436, 0362-2436 KW - Index Medicus KW - Exercise Test KW - Risk Factors KW - Humans KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Physical Examination KW - Occupational Diseases -- diagnosis KW - Back Pain -- epidemiology KW - Back Pain -- diagnosis KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80716828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Spine&rft.atitle=Standardized+tests+and+measures+for+assessing+low-back+pain+in+the+occupational+setting.+A+developmental+model.&rft.au=Nelson%2C+R+M&rft.aulast=Nelson&rft.aufirst=R&rft.date=1991-06-01&rft.volume=16&rft.issue=6&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Spine&rft.issn=03622436&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-05 N1 - Date created - 1991-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation. AN - 80612865; 2046705 AB - The antihistamine methapyrilene hydrochloride has been shown to be a potent hepatocarcinogen in Fischer 344 rats. It has also been evaluated in a number of short-term in vivo and in vitro genotoxicity assays with conflicting results. We studied its ability to form DNA adducts in the L5178Y/TK+/- mouse lymphoma cells, an assay system in which methapyrilene is a moderately active mutagen and appears to induce mutations predominantly of chromosomal origin. Methapyrilene failed to induce formation of DNA adducts in L5178Y cell DNA at doses which induced mutations at the thymidine kinase locus. These data suggest that methapyrilene induces mutations in this system through an indirect genotoxic mechanism; e.g., via an oxidative mechanism or interaction with chromosomal proteins. JF - Mutation research AU - Casciano, D A AU - Talaska, G AU - Clive, D AD - National Center for Toxicological Research, Division of Genetic Toxicology, Jefferson, AR 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 127 EP - 132 VL - 263 IS - 2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Mutagens KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Methapyrilene KW - A01LX40298 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Animals KW - Tumor Cells, Cultured KW - 2-Acetylaminofluorene -- pharmacology KW - Chromosome Aberrations KW - Mice KW - Colony-Forming Units Assay KW - DNA Damage KW - Methapyrilene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80612865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+potent+hepatocarcinogen+methapyrilene+induces+mutations+in+L5178Y+mouse+lymphoma+cells+in+the+apparent+absence+of+DNA+adduct+formation.&rft.au=Casciano%2C+D+A%3BTalaska%2C+G%3BClive%2C+D&rft.aulast=Casciano&rft.aufirst=D&rft.date=1991-06-01&rft.volume=263&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-16 N1 - Date created - 1991-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes in forced expiratory volume in one second and peak expiratory flow rate across a work shift among unexposed blue collar workers. AN - 80609897; 2048805 AB - Pre- and postshift spirometry was obtained on 1,113 blue collar workers employed at 35 work sites judged to have no hazardous occupational respiratory exposures on the basis of inspection visits and environmental sampling. In addition to spirometry, a standardized questionnaire was administered by trained personnel. A study population of 944 remained after exclusion of workers for incomplete demographic data and/or spirometry with poor within-session reproducibility, i.e., greater than or equal to 10% variability in the two largest values of either FVC and/or FEV1. Overall mean values of changes across the work shift in FEV1 and peak expiratory flow rate (PEFR) were -0.8% (-0.04 L) and +2.1% (+0.13 L/s), respectively. Standard deviations for these across-shift changes were 5.8% (0.19 L) and 13.2% (1.19 L/s) for FEV1 and PEFR, respectively. In univariate analyses, mean values of across-shift changes were not statistically related to age, race, sex, smoking status, work shift, or FEV1/FVC ratio. However, variability (i.e., standard deviation) of across-shift changes were significantly related to some of these factors. These observations provide a basis for interpreting results of occupational respiratory morbidity surveys involving measurement of changes in FEV1 and/or PEFR across a work shift. JF - The American review of respiratory disease AU - Ghio, A J AU - Castellan, R M AU - Kinsley, K B AU - Hankinson, J L AD - Clinical Investigations Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 1231 EP - 1234 VL - 143 IS - 6 SN - 0003-0805, 0003-0805 KW - Abridged Index Medicus KW - Index Medicus KW - Reference Values KW - Vital Capacity KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Time Factors KW - Peak Expiratory Flow Rate KW - Environmental Exposure KW - Forced Expiratory Volume KW - Occupational Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80609897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Changes+in+forced+expiratory+volume+in+one+second+and+peak+expiratory+flow+rate+across+a+work+shift+among+unexposed+blue+collar+workers.&rft.au=Ghio%2C+A+J%3BCastellan%2C+R+M%3BKinsley%2C+K+B%3BHankinson%2C+J+L&rft.aulast=Ghio&rft.aufirst=A&rft.date=1991-06-01&rft.volume=143&rft.issue=6&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-12 N1 - Date created - 1991-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational exposure to radon daughters in Mammoth Cave National Park. AN - 80560794; 1851736 JF - Health physics AU - Eheman, C AU - Carson, B AU - Rifenburg, J AU - Hoffman, D AD - Radiation Studies Branch, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 831 EP - 835 VL - 60 IS - 6 SN - 0017-9078, 0017-9078 KW - Radon Daughters KW - 0 KW - Lead KW - 2P299V784P KW - Polonium KW - DQY03U61EJ KW - Bismuth KW - U015TT5I8H KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Kentucky KW - Male KW - Female KW - Occupational Exposure KW - Polonium -- analysis KW - Mining KW - Bismuth -- analysis KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80560794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Occupational+exposure+to+radon+daughters+in+Mammoth+Cave+National+Park.&rft.au=Eheman%2C+C%3BCarson%2C+B%3BRifenburg%2C+J%3BHoffman%2C+D&rft.aulast=Eheman&rft.aufirst=C&rft.date=1991-06-01&rft.volume=60&rft.issue=6&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-24 N1 - Date created - 1991-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Agricultural machine-related deaths. AN - 80559022; 2029052 AB - Analysis of 1980-1985 death certificate data for the United States indicated that an average of 369 occupational deaths per year involved agricultural machinery as the external cause of death. Out of all agricultural machine-related deaths, tractors accounted for 69 percent. Over half of these tractor-related deaths were rollovers. There is a need for public health programs to affect greater use of rollover protective structures (ROPS) on farm tractors. JF - American journal of public health AU - Etherton, J R AU - Myers, J R AU - Jensen, R C AU - Russell, J C AU - Braddee, R W AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 766 EP - 768 VL - 81 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Death Certificates KW - Databases, Factual KW - United States Occupational Safety and Health Administration KW - Accident Prevention KW - United States -- epidemiology KW - Cause of Death KW - Accidents, Occupational -- prevention & control KW - Accidents, Occupational -- classification KW - Agriculture -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80559022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Agricultural+machine-related+deaths.&rft.au=Etherton%2C+J+R%3BMyers%2C+J+R%3BJensen%2C+R+C%3BRussell%2C+J+C%3BBraddee%2C+R+W&rft.aulast=Etherton&rft.aufirst=J&rft.date=1991-06-01&rft.volume=81&rft.issue=6&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1979 Feb;69(2):146-9 [760571] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Public Health Rep. 1985 May-Jun;100(3):329-33 [3923543] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Female homicides in United States workplaces, 1980-1985. AN - 80558429; 2029041 AB - Women, while noted for low occupational injury mortality rates, are more likely to die as victims of assault than from any other manner of injury at work. From the National Traumatic Occupational Fatality surveillance data, 950 women were identified who were fatally assaulted at work. Homicide rates were calculated for the demographic and employment characteristics of these women. Risk ratios among types of lethal injuries were examined. During 1980-1985, the crude six-year workplace homicide rate was 4.0 deaths per million working women: one twentieth the homicide rate of the US female population. Decedents ranged from 16 years (the lowest age included in the data base) to 93 years of age. Working women older than 65 years had the highest age-specific homicide rate, 11.3 per million. Women younger than 20 had the lowest, 2.5 per million per year. Homicide rates for women of races other than White were nearly twice as high as those of Whites. The leading causes of death were gunshot wounds (64 percent), stabbings (19 percent), asphyxiations (7 percent), and blunt force trauma (6 percent). Nearly 43 percent of the deceased women had been employed in retail trade: 8.7 per million employed women annually. During 1980-1985, only 6 percent of the nation's victims of work-related injury deaths were female: 41 percent of those women were murdered. Homicide is currently the leading manner of traumatic workplace death among women in the United States. JF - American journal of public health AU - Bell, C A AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 729 EP - 732 VL - 81 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Sex Factors KW - Humans KW - Aged KW - Cause of Death KW - Population Surveillance KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Death Certificates KW - Databases, Factual KW - United States Occupational Safety and Health Administration KW - Middle Aged KW - Adolescent KW - Occupations KW - United States -- epidemiology KW - Female KW - Industry KW - Homicide -- classification KW - Homicide -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80558429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Female+homicides+in+United+States+workplaces%2C+1980-1985.&rft.au=Bell%2C+C+A&rft.aulast=Bell&rft.aufirst=C&rft.date=1991-06-01&rft.volume=81&rft.issue=6&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1982 Aug 13;248(6):692-7 [7097919] N Engl J Med. 1985 Nov 14;313(20):1263-9 [4058507] Am J Public Health. 1987 Oct;77(10):1285-9 [3631361] Am J Public Health. 1987 Oct;77(10):1290-3 [3631362] Am J Public Health. 1987 Dec;77(12):1524-7 [3674251] Am J Public Health. 1991 Jun;81(6):725-8 [1827569] J Occup Med. 1988 Jun;30(6):483-7 [3392614] Am J Public Health. 1988 Dec;78(12):1579-81 [3189637] Am J Ind Med. 1988;14(2):121-36 [3207099] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Am J Public Health. 1987 Dec;77(12):1532-4 [3674253] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effectiveness of source documents for identifying fatal occupational injuries: a synthesis of studies. AN - 80556173; 1827569 AB - The complete and accurate identification of fatal occupational injuries among the US work force is an important first step in developing work injury prevention efforts. Numerous sources of information, such as death certificates, Workers' Compensation files, Occupational Safety and Health Administration (OSHA) files, medical examiner records, state health and labor department reports, and various combinations of these, have been used to identify cases of work-related fatal injuries. Recent studies have questioned the effectiveness of these sources for identifying such cases. At least 10 studies have used multiple sources to define the universe of fatal work injuries within a state and to determine the capture rates, or proportion of the universe identified, by each source. Results of these studies, which are not all available in published literature, are summarized here in a format that allows researchers to readily compare the ascertainment capabilities of the sources. The overall average capture rates of sources were as follows: death certificates, 81%; medical examiner records, 61%; Workers' Compensation reports, 57%; and OSHA reports 32%. Variations by state and value added through the use of multiple sources are presented and discussed. This meta-analysis of 10 state-based studies summarizes the effectiveness of various source documents for capturing cases of fatal occupational injuries to help researchers make informed decisions when designing occupational injury surveillance systems. JF - American journal of public health AU - Stout, N AU - Bell, C AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 725 EP - 728 VL - 81 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Evaluation Studies as Topic KW - Coroners and Medical Examiners KW - Humans KW - State Health Planning and Development Agencies KW - Death Certificates KW - Workers' Compensation KW - United States Occupational Safety and Health Administration KW - Meta-Analysis as Topic KW - Population Surveillance -- methods KW - Data Collection -- standards KW - Data Collection -- methods KW - Accidents, Occupational -- mortality KW - Documentation -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80556173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Effectiveness+of+source+documents+for+identifying+fatal+occupational+injuries%3A+a+synthesis+of+studies.&rft.au=Stout%2C+N%3BBell%2C+C&rft.aulast=Stout&rft.aufirst=N&rft.date=1991-06-01&rft.volume=81&rft.issue=6&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1988 Sep;78(9):1218-9 [3407825] Am J Public Health. 1988 Sep;78(9):1215-7 [3407824] Am J Ind Med. 1989;15(6):669-78 [2750742] J Occup Med. 1988 Nov;30(11):868-72 [3230433] JAMA. 1982 Aug 13;248(6):692-7 [7097919] JAMA. 1990 Jun 13;263(22):3047-50 [2342216] Am J Public Health. 1990 Feb;80(2):200-2 [2297066] Am J Public Health. 1990 Feb;80(2):198-200 [2297065] J Occup Med. 1986 Feb;28(2):100-2 [3754006] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biomarkers of aging: an overview. AN - 72116857; 1910590 JF - Biomedical and environmental sciences : BES AU - Turturro, A AU - Hart, R W AD - National Center for Toxicological Research, Jefferson, Akansas 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 130 EP - 133 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Hazardous Substances KW - Index Medicus KW - Disease Susceptibility KW - DNA Damage KW - Humans KW - Aging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72116857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biomarkers+of+aging%3A+an+overview.&rft.au=Turturro%2C+A%3BHart%2C+R+W&rft.aulast=Turturro&rft.aufirst=A&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biomarkers of human exposure to carcinogens: an overview. AN - 72116629; 1910602 JF - Biomedical and environmental sciences : BES AU - Beland, F A AU - Poirier, M C AD - National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 69 EP - 72 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Carcinogens KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Humans KW - Neoplasms -- chemically induced KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72116629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biomarkers+of+human+exposure+to+carcinogens%3A+an+overview.&rft.au=Beland%2C+F+A%3BPoirier%2C+M+C&rft.aulast=Beland&rft.aufirst=F&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biomarkers of neurotoxicity: an overview. AN - 72114392; 1910595 JF - Biomedical and environmental sciences : BES AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 192 EP - 196 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72114392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biomarkers+of+neurotoxicity%3A+an+overview.&rft.au=Slikker%2C+W&rft.aulast=Slikker&rft.aufirst=W&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biogenic amines as biomarkers for neurotoxicity. AN - 72113770; 1680343 AB - There has been a surge of interest over the past several years in the use of neurochemical endpoints to contribute to our understanding of the mechanism of action of neurotoxicants. In our present presentation, two biogenic amine systems were selected as examples of biomarkers for neurotoxicity. To investigate these neurochemical endpoints, two prototype neurotoxicants were evaluated in experimental animals. One agent, reserpine, was used to assess developmental neurotoxicity and administered prenatally, while the other, MDMA, was used in the adult animal. The neurochemical biomarkers measured were dopamine, serotonin, and their metabolite (DOPAC and 5-HIAA) concentrations by HPLC/EC and dopamine receptor binding by radioligand receptor techniques. A review of the background, experimental design, and results are presented in this article. Our findings indicate that components of the biogenic amine systems can be used as sensitive neurochemical biomarkers of neurotoxicity. These neurochemical biomarkers can be correlated with neuropathological and behavioral biomarkers to aid in the understanding of mechanisms of neurotoxicity. JF - Biomedical and environmental sciences : BES AU - Ali, S F AU - Chang, L W AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 207 EP - 216 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biogenic Amines KW - 0 KW - Biomarkers KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Reserpine KW - 8B1QWR724A KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Animals KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - Reserpine -- toxicity KW - 3,4-Methylenedioxyamphetamine -- toxicity KW - Female KW - Biogenic Amines -- metabolism KW - Nervous System -- drug effects KW - Nervous System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Biogenic+amines+as+biomarkers+for+neurotoxicity.&rft.au=Ali%2C+S+F%3BChang%2C+L+W%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recent advances in biomarker research. Introduction. AN - 72113734; 1910597 JF - Biomedical and environmental sciences : BES AU - Hart, R W AU - Chang, L W AU - Turturro, A AU - Kadlubar, F F AD - DHHS/PHS/FDA, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 2 EP - 7 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - Animals KW - Disease Susceptibility KW - Humans KW - Environmental Pollutants -- toxicity KW - Environmental Pollutants -- economics KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Recent+advances+in+biomarker+research.+Introduction.&rft.au=Hart%2C+R+W%3BChang%2C+L+W%3BTurturro%2C+A%3BKadlubar%2C+F+F&rft.aulast=Hart&rft.aufirst=R&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Critical considerations in the immunochemical detection and quantitation of antigenic biomarkers. AN - 72113703; 1910589 AB - The formation of covalent adducts as a result of the interaction of metabolically activated chemicals with host macromolecules is a common critical event in mutagenic, carcinogenic, and immunologic phenomena. Because of their antigenicity and their immunogenicity, covalent adducts may be detected using sensitive immunochemical techniques. The immunochemical approaches to biomonitoring and molecular dosimetry of DNA damage are particularly attractive because they allow sensitive quantitation of specific DNA adducts present in small samples and do not rely on the use of radiolabeled adducts. Two examples of biomarker immunoassay development are presented: an avidin/biotin-amplified ELISA for the major DNA adduct of the human bladder carcinogen 4-aminobiphenyl (ABP), and a particle concentration fluorescent immunoassay (PCFIA) for the major protein adduct associated with toxicity by the prototype hepatotoxin acetaminophen. The examples illustrate critical steps in the development of biomarker immunoassays which include selection of the relevant adduct, preparation of an appropriate immunogen, immunization, characterization of antisera, and development of application-specific sample processing techniques for biomarker quantitation. Immunochemical procedures may be combined with other analytical techniques to form hybrid systems which take advantage of both the antigenicity and the physical or chemical properties of a biomarker to achieve greater specificity and/or sensitivity. The future usefulness of these new tools of molecular epidemiology will depend on a compound-by-compound validation of methods and critical evaluation of the biologic importance of the particular antigenic biomarker as an indicator of exposure and as an indicator of risk. JF - Biomedical and environmental sciences : BES AU - Roberts, D W AU - Benson, R W AU - Hinson, J A AU - Kadlubar, F F AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 113 EP - 129 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Aminobiphenyl Compounds KW - 0 KW - Antigens KW - Biomarkers KW - Carcinogens KW - 4-biphenylamine KW - 16054949HJ KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Sensitivity and Specificity KW - Carcinogens -- metabolism KW - Aminobiphenyl Compounds -- toxicity KW - DNA Damage KW - Humans KW - Acetaminophen -- metabolism KW - Aminobiphenyl Compounds -- metabolism KW - Acetaminophen -- toxicity KW - Immunoassay KW - Immunochemistry -- methods KW - Antigens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Critical+considerations+in+the+immunochemical+detection+and+quantitation+of+antigenic+biomarkers.&rft.au=Roberts%2C+D+W%3BBenson%2C+R+W%3BHinson%2C+J+A%3BKadlubar%2C+F+F&rft.aulast=Roberts&rft.aufirst=D&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of dietary restriction and aging on in vivo and in vitro binding of aflatoxin B1 to cellular DNA. AN - 72112798; 1910591 AB - Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary restriction on laboratory animals have been suggested to be related to a deceleration of the aging process. The inhibition of age-related changes in xenobiotic metabolizing enzymes activities by dietary restriction has previously been reported. Alterations of these enzyme activities may cause changes in metabolic activation of carcinogens and, therefore, carcinogen-DNA binding. DNA-repair capability has also been reported to be enhanced in diet-restricted rats. Using AFB1 as a model carcinogen, we have studied in vivo and in vitro hepatic AFB1-DNA binding, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1, and subsequently reduce AFB1-DNA binding. Our preliminary results obtained from the AFB1-DNA binding experiments in isolated hepatocytes suggest that the observed age-dependent reduction in AFB1-DNA binding which may be attributed to a loss of metabolic activating capability was delayed in the diet-restricted rats. JF - Biomedical and environmental sciences : BES AU - Chou, M W AU - Pegram, R A AU - Gao, P AU - Hansard, S R AU - Shaddock, J G AU - Casciano, D A AD - National Center for Toxicological Research, Jefferson, Arkansas, AR 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 134 EP - 143 VL - 4 IS - 1-2 SN - 0895-3988, 0895-3988 KW - Xenobiotics KW - 0 KW - DNA KW - 9007-49-2 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Liver -- drug effects KW - Biotransformation KW - Xenobiotics -- metabolism KW - Aging -- metabolism KW - Aflatoxin B1 -- metabolism KW - Aflatoxin B1 -- pharmacokinetics KW - DNA -- metabolism KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72112798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=The+effects+of+dietary+restriction+and+aging+on+in+vivo+and+in+vitro+binding+of+aflatoxin+B1+to+cellular+DNA.&rft.au=Chou%2C+M+W%3BPegram%2C+R+A%3BGao%2C+P%3BHansard%2C+S+R%3BShaddock%2C+J+G%3BCasciano%2C+D+A&rft.aulast=Chou&rft.aufirst=M&rft.date=1991-06-01&rft.volume=4&rft.issue=1-2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of trimethyltin on amino acid concentrations in different regions of the mouse brain. AN - 72090697; 1891440 AB - Trimethyltin (TMT) is a neurotoxic compound known to cause marked alterations in brain chemistry. We have previously demonstrated that a single oral dose of TMT produced a dose-dependent decrease in muscarinic cholinergic receptors in mouse brain and significantly elevated glutamine in several regions of the rat brain. This study was designed to determine if TMT produced dose- and time-related alterations in amino acid concentrations in the adult male C57BL/6N mouse brain and in peripheral organs and plasma. In the dose-response study, TMT was administered orally as a single dose of 0, 0.5, 1.0, 3.0 or 5.0 mg/kg and animals were sacrificed 24 hr after treatment. In the time-course study, mice were dosed with TMT at 3.0 mg/kg and sacrificed 4, 12, 24, 48 or 96 hr after dosing. Amino acid concentrations were quantified by HPLC/EC following precolumn derivatization with o-phthalaldehyde-tert-butylthiol. TMT produced dose-dependent increases in aspartate, glutamine and glycine in the caudate nucleus (CN), frontal cortex (FC) and hippocampus (HIP) at 3.0 and 5.0 mg/kg. TMT at 3.0 mg/kg produced significant increases of aspartate in FC and HIP after 48 hr. Glutamine concentrations were significantly increased at 24 and 48 hr in HIP and at 48 hr in CN. Glycine and GABA concentrations were significantly increased at 48 and 96 hr respectively in the HIP. Glutamine was increased in plasma at 4 and 12 hr and in liver at 24 hr. Hyperammonemia occurred in plasma after 8 hr and continued through 24 hr and was accompanied by an increase in serum urea nitrogen.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Pharmacology & toxicology AU - Lipe, G W AU - Ali, S F AU - Newport, G D AU - Scallet, A C AU - Slikker, W AD - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 450 EP - 455 VL - 68 IS - 6 SN - 0901-9928, 0901-9928 KW - Amino Acids KW - 0 KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Ammonia -- blood KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - Blood Urea Nitrogen KW - Male KW - Amino Acids -- isolation & purification KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Trimethyltin Compounds -- administration & dosage KW - Brain -- metabolism KW - Amino Acids -- metabolism KW - Trimethyltin Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72090697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+toxicology&rft.atitle=Effect+of+trimethyltin+on+amino+acid+concentrations+in+different+regions+of+the+mouse+brain.&rft.au=Lipe%2C+G+W%3BAli%2C+S+F%3BNewport%2C+G+D%3BScallet%2C+A+C%3BSlikker%2C+W&rft.aulast=Lipe&rft.aufirst=G&rft.date=1991-06-01&rft.volume=68&rft.issue=6&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+toxicology&rft.issn=09019928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-17 N1 - Date created - 1991-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Marked increase in the teratogenicity of the combined administration of the industrial solvent 2-methoxyethanol and radiofrequency radiation in rats. AN - 72066065; 1882353 AB - Limited published animal research reports synergistic teratogenic effects following combined hyperthermia (induced by elevated ambient temperature) and administration of chemical teratogens. Radiofrequency (RF) radiation is widely used in occupational environments. Since RF radiation also elevates the body temperature of, and is teratogenic to, exposed animals, concurrent RF radiation and chemical agent administration may enhance teratogenicity. The present exploratory study, consisting of preliminary dose-finding studies and the primary study, was designed to investigate whether concurrent exposure of rats to RF radiation and the industrial solvent 2-methoxyethanol (2ME) can enhance the developmental toxicity of either agent acting alone. Preliminary dose-finding studies using small numbers of rats investigated the ability of various RF radiation conditions and doses of 2ME to produce external malformations (primarily of the paws) when administered on gestation day 13. Based on these preliminary studies, RF radiation exposure [sufficient to elevate rectal temperature to 42.0 degrees C (4 degrees C above normal for rats) for 30 min] and 2ME administration (150 mg/kg) were selected for the primary study. In the primary study, groups of 18 to 27 pregnant rats were administered RF radiation exposure and distilled water gavage, 2ME gavage and sham RF exposure, RF radiation exposure and 2ME gavage concurrently, or sham RF exposure and distilled water gavage. Pregnant rats were sacrificed on gestation day 20, and the offspring were examined for external malformations. Combined exposures enhanced the adverse effects produced by either experimental agent alone (no malformations were detected in the double sham group). Mean fetal malformations/litter increased from 14% after 2ME and sham RF (15/26 litters affected, with an average of 2 fetuses/litter malformed) and 30% after RF radiation and water gavage (10/18 litters affected, with an average of 4 fetuses/litter malformed), to 76% after the combined treatment (18/18 litters affected, with an average of 12 fetuses/litter malformed). In addition to a significant increase in the frequency of malformations, the severity of malformations also was enhanced by the combination treatment (on a relative severity ranking scale, the 2ME severity score was less than 1, the RF score was 3, and the combination score was 6). This study provided evidence of synergism between RF radiation and 2ME administration, but additional research will be required to characterize the extent of synergism between these two agents. Potential interactive effects between chemical and physical agents need to be investigated to determine the extent to which such interactions should impact occupational exposure standards. JF - Teratology AU - Nelson, B K AU - Conover, D L AU - Brightwell, W S AU - Shaw, P B AU - Werren, D AU - Edwards, R M AU - Lary, J M AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 621 EP - 634 VL - 43 IS - 6 SN - 0040-3709, 0040-3709 KW - Ethylene Glycols KW - 0 KW - methyl cellosolve KW - EK1L6XWI56 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Occupational Exposure KW - Maternal-Fetal Exchange KW - Animals KW - Dose-Response Relationship, Drug KW - Dose-Response Relationship, Radiation KW - Female KW - Pregnancy KW - Fetal Death KW - Ethylene Glycols -- toxicity KW - Infrared Rays -- adverse effects KW - Congenital Abnormalities -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72066065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Marked+increase+in+the+teratogenicity+of+the+combined+administration+of+the+industrial+solvent+2-methoxyethanol+and+radiofrequency+radiation+in+rats.&rft.au=Nelson%2C+B+K%3BConover%2C+D+L%3BBrightwell%2C+W+S%3BShaw%2C+P+B%3BWerren%2C+D%3BEdwards%2C+R+M%3BLary%2C+J+M&rft.aulast=Nelson&rft.aufirst=B&rft.date=1991-06-01&rft.volume=43&rft.issue=6&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-03 N1 - Date created - 1991-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro. AN - 72065193; 1882348 AB - The anticonvulsant drug valproic acid (VPA) is suspected to be a developmental toxicant in humans, inducing primarily neural tube defects. The mechanism for this effect is unknown, but it has been suggested that the drug may act via a deficiency of the vitamin folic acid. We examined this possibility by concurrent treatment of rat embryos in a whole embryo culture system with VPA and folinic acid (FA), a folic acid derivative. Groups of CD rat embryos were treated with various concentrations of VPA, various concentrations of FA, or a combination of a teratogenic dose of VPA plus various levels of FA. At the end of the 44 hour culture period, each embryo was evaluated for viability (presence of a heartbeat), yolk sac circulation, presence of any malformations, morphological score, crown-rump and head lengths, as well as DNA and protein contents. The anticonvulsant did not decrease viability but did decrease yolk sac circulation and all growth and developmental endpoints in a dose-responsive manner. There was also a dose-related increase in the incidence of open neural tubes. The addition of FA alone had no significant effect on growth and development. When various concentrations of FA were added simultaneously with a teratogenic dose of VPA, there was no decrease in the incidence of open neural tubes. Growth and developmental endpoints were altered in a somewhat random fashion but were never increased to the control level. The lack of attenuation by FA was not due to instability of the compound in the culture system, nor was there a difference in the amount of FA present in the exocoelomic fluid of VPA-treated and control embryos.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Teratology AU - Hansen, D K AU - Grafton, T F AD - Division of Reproductive and Developmental Toxicology, Food and Drug Administration, Jefferson, Arkansas 72079-9502. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 575 EP - 582 VL - 43 IS - 6 SN - 0040-3709, 0040-3709 KW - Valproic Acid KW - 614OI1Z5WI KW - Leucovorin KW - Q573I9DVLP KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Fetal Death -- chemically induced KW - Female KW - Pregnancy KW - Leucovorin -- toxicity KW - Valproic Acid -- toxicity KW - Neural Tube Defects -- chemically induced KW - Leucovorin -- pharmacology KW - Embryo, Mammalian -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72065193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Lack+of+attenuation+of+valproic+acid-induced+effects+by+folinic+acid+in+rat+embryos+in+vitro.&rft.au=Hansen%2C+D+K%3BGrafton%2C+T+F&rft.aulast=Hansen&rft.aufirst=D&rft.date=1991-06-01&rft.volume=43&rft.issue=6&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-03 N1 - Date created - 1991-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mortality among workers exposed to ethylene oxide. AN - 80522864; 2020295 AB - Ethylene oxide is a sterilant gas that causes leukemia and other cancers in animals. Studies in Sweden have shown an excess of leukemia and stomach cancer in humans exposed to ethylene oxide, but other studies have generally failed to confirm these findings. We conducted a study of mortality in 18,254 U.S. workers exposed to ethylene oxide at 14 plants producing sterilized medical supplies and spices. The subjects averaged 4.9 years of exposure to the gas and 16 years of follow-up. The exposure levels in recent years averaged 4.3 ppm (eight-hour time-weighted adjusted exposure) for sterilizer operators and 2.0 ppm for other workers. The levels in earlier years are likely to have been several times higher. Mortality in this cohort was compared with that in the general U.S. population. Overall there was no significant increase in mortality from any cause in the study cohort. The standardized mortality ratios (SMRs) were 0.97 for leukemia (95 percent confidence interval, 0.52 to 1.67; 13 deaths observed), 1.06 for all hematopoietic cancers (95 percent confidence interval, 0.75 to 1.47; 36 deaths), and 0.94 for stomach cancer (95 percent confidence interval, 0.45 to 1.70; 11 deaths). Analyses according to job category and according to the duration of exposure showed no excess in cancers, as compared with the rate in the general population, but there was a significant trend toward increased mortality with increasing lengths of time since the first exposure for all hematopoietic cancers. The rate of death from hematopoietic cancer (especially non-Hodgkin's lymphoma) was significantly increased among men (SMR, 1.55; 27 deaths). Mortality from leukemia in recent years (1985 through 1987) was significantly increased among men (SMR, 3.45; 5 deaths). For the entire cohort, there was no increase in mortality from hematopoietic cancer. There was a slight but significant increase among men, however. Among men and women combined, there was a trend toward an increased risk of death from hematopoietic cancer with increasing lengths of time since the first exposure to ethylene oxide. JF - The New England journal of medicine AU - Steenland, K AU - Stayner, L AU - Greife, A AU - Halperin, W AU - Hayes, R AU - Hornung, R AU - Nowlin, S AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/05/16/ PY - 1991 DA - 1991 May 16 SP - 1402 EP - 1407 VL - 324 IS - 20 SN - 0028-4793, 0028-4793 KW - Ethylene Oxide KW - JJH7GNN18P KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Exposure KW - Lymphoma -- mortality KW - Leukemia -- mortality KW - Stomach Neoplasms -- mortality KW - Neoplasms -- mortality KW - Humans KW - Cohort Studies KW - United States -- epidemiology KW - Time Factors KW - Male KW - Female KW - Occupational Diseases -- mortality KW - Mortality KW - Ethylene Oxide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80522864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Mortality+among+workers+exposed+to+ethylene+oxide.&rft.au=Steenland%2C+K%3BStayner%2C+L%3BGreife%2C+A%3BHalperin%2C+W%3BHayes%2C+R%3BHornung%2C+R%3BNowlin%2C+S&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-05-16&rft.volume=324&rft.issue=20&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-30 N1 - Date created - 1991-05-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Oct 24;325(17):1254 [1922217] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice. AN - 80552471; 1674234 AB - Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice. To assess differences in PB induction of hepatic drug metabolizing enzymes, yellow Avy/A (C3H x VY) F1 hybrid male mice were fed 0.05% sodium PB in NIH-31 diet for 7 months. Livers from the heaviest and lightest mice in the untreated and PB groups were assayed. Total cytochrome P450 content, cytochrome P450IA-selective 7-ethoxyresorufin-O-deethylase and P450IIIA-selective testosterone-6 beta-hydroxylase activities were preferentially induced in the light mice. In contrast, P450IIB-selective 7-pentoxyresorufin-O-dealkylase activity was increased only 3-fold by PB in the light mice but 6-fold in the heavy mice. Testosterone UDP-glucuronyltransferase and gamma-glutamyltranspeptidase activities were induced in the light mice but not in the heavy mice. Glutathione-S-transferase N1:1-dependent activity was induced preferentially in the heavy mice. Significant differences also occurred in constitutive expression of P450IIIA-selective testosterone-6 beta-hydroxylase, P450IA-selective 7-ethoxyresorufin-O-deethylase and testosterone UDP-glucuronyltransferase activities between the untreated weight groups. Thus, expression of constitutive and PB-inducible forms of hepatic drug metabolizing enzymes differs between heavy and light Avy/A (C3H x VY) F1 hybrid subpopulations. This suggests that differential susceptibility to PB promotion of hepatocellular adenomas among genetically identical mice is accompanied by differences in the regulation of gene expression. JF - Carcinogenesis AU - Wolff, G L AU - Leakey, J E AU - Bazare, J J AU - Harmon, J R AU - Webb, P J AU - Law, M G AD - Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 911 EP - 915 VL - 12 IS - 5 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Isoenzymes KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Oxidoreductases KW - Steroid Hydroxylases KW - EC 1.14.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP2B1 KW - testosterone 7-alpha-hydroxylase, hamster KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - gamma-Glutamyltransferase -- metabolism KW - Glutathione Transferase -- metabolism KW - Steroid Hydroxylases -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Glucuronosyltransferase -- metabolism KW - Mice KW - Organ Size KW - Isoenzymes -- metabolism KW - Body Weight KW - Blotting, Western KW - Mixed Function Oxygenases -- metabolism KW - Oxidoreductases -- metabolism KW - Adenoma -- enzymology KW - Male KW - Microsomes, Liver -- enzymology KW - Liver Neoplasms -- chemically induced KW - Phenobarbital -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80552471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Susceptibility+to+phenobarbital+promotion+of+hepatotumorigenesis%3A+correlation+with+differential+expression+and+induction+of+hepatic+drug+metabolizing+enzymes+in+heavy+and+light+male+%28C3H+x+VY%29+F1+hybrid+mice.&rft.au=Wolff%2C+G+L%3BLeakey%2C+J+E%3BBazare%2C+J+J%3BHarmon%2C+J+R%3BWebb%2C+P+J%3BLaw%2C+M+G&rft.aulast=Wolff&rft.aufirst=G&rft.date=1991-05-01&rft.volume=12&rft.issue=5&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-19 N1 - Date created - 1991-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse reaction reporting of interaction between warfarin and fluoroquinolones. AN - 80545454; 1842668 AB - Reports to the Food and Drug Administration's Adverse Drug Reaction Reporting System of prolonged prothrombin time due to a suspected interaction between warfarin sodium and a fluoroquinolone were reviewed. Five reports of patients who experienced this adverse reaction 2 to 16 days after the addition of a fluoroquinolone to their treatment regimen are described. Possible mechanisms of action that are discussed include inhibition of warfarin metabolism by the anti-infective agent and displacement of warfarin's binding to protein. Physicians need to be aware of this interaction and closely monitor prothrombin time in patients concurrently receiving warfarin and a fluoroquinolone. JF - Archives of internal medicine AU - Jolson, H M AU - Tanner, L A AU - Green, L AU - Grasela, T H AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 1003 EP - 1004 VL - 151 IS - 5 SN - 0003-9926, 0003-9926 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Warfarin KW - 5Q7ZVV76EI KW - Norfloxacin KW - N0F8P22L1P KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Drug Interactions KW - United States Food and Drug Administration KW - Aged, 80 and over KW - Humans KW - Adult KW - Product Surveillance, Postmarketing KW - Aged KW - Middle Aged KW - Male KW - Female KW - Warfarin -- adverse effects KW - Norfloxacin -- adverse effects KW - Ciprofloxacin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80545454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Adverse+reaction+reporting+of+interaction+between+warfarin+and+fluoroquinolones.&rft.au=Jolson%2C+H+M%3BTanner%2C+L+A%3BGreen%2C+L%3BGrasela%2C+T+H&rft.aulast=Jolson&rft.aufirst=H&rft.date=1991-05-01&rft.volume=151&rft.issue=5&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1992 Jul;152(7):1533-4 [1627042] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Urolithiasis in Tennessee: an occupational window into a regional problem. AN - 80511095; 2014858 AB - Urinary tract stones (stones) are believed to be unusually common in the southeastern United States but neither the incidence of nor the risk factors for stones are known. In three well-defined occupational populations in eastern Tennessee, we assessed the prevalence, incidence, and cumulative incidence of stones and measured biochemical risk factors for lithogenesis. The age-adjusted prevalence of stones was 18.5 percent in Tennessee compared to 7.7 percent among White males in US NHANES (prevalence ratio 2.4, 95% CI 1.7, 3.3). The cumulative incidence (risk) was 27.8 percent by age 65, higher than in any other reported population. Risk factors were age, a family history, and urinary saturation with calcium-oxalate (COAX). Persons with a positive family history and the highest measured CAOX index had a predicted lifetime risk of 88.8 percent. Biochemical factors affecting lithogenesis were hypercalciuria, hyperoxaluria, and low urine volume. Future research should characterize the geographic boundaries of a southeastern "stone-belt" and explore genetic and dietary hypotheses that might explain it. JF - American journal of public health AU - Thun, M J AU - Schober, S AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 587 EP - 591 VL - 81 IS - 5 SN - 0090-0036, 0090-0036 KW - Calcium Oxalate KW - 2612HC57YE KW - Uranium KW - 4OC371KSTK KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Aged KW - Dairying KW - Uranium -- adverse effects KW - Calcium Oxalate -- urine KW - Logistic Models KW - Risk Factors KW - Tennessee -- epidemiology KW - Adult KW - Incidence KW - Middle Aged KW - Occupations KW - Urine -- chemistry KW - Male KW - Metallurgy KW - Prevalence KW - Kidney Calculi -- chemically induced KW - Kidney Calculi -- epidemiology KW - Kidney Calculi -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80511095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Urolithiasis+in+Tennessee%3A+an+occupational+window+into+a+regional+problem.&rft.au=Thun%2C+M+J%3BSchober%2C+S&rft.aulast=Thun&rft.aufirst=M&rft.date=1991-05-01&rft.volume=81&rft.issue=5&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-16 N1 - Date created - 1991-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Urol. 1979 Sep;122(3):288-91 [469997] Kidney Int. 1979 Nov;16(5):624-31 [548606] Am J Epidemiol. 1982 Feb;115(2):255-65 [7058784] J Urol. 1982 Aug;128(2):422-5 [7109123] J Chronic Dis. 1985;38(11):907-14 [4055979] J Urol. 1985 Nov;134(5):867-70 [4057368] Invest Urol. 1978 May;15(6):438-41 [649290] Aviat Space Environ Med. 1989 Feb;60(2):157-61 [2930428] N Engl J Med. 1989 May 11;320(19):1238-43 [2651928] Am J Med. 1968 Nov;45(5):715-35 [4879833] N Engl J Med. 1974 Dec 19;291(25):1344-50 [4610395] Lancet. 1975 May 10;1(7915):1063-5 [48731] Br J Urol. 1987 Jul;60(1):10-3 [3620841] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data. AN - 72447102; 1935845 AB - The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study. The model successfully predicts liver tumor incidence for time points beyond termination of dosing with 2-acetylaminofluorene, but it is unsuccessful for bladder tumor incidence. A discontinued dosing version of the Weibull model is proposed and is shown to predict successfully both liver and bladder tumor incidences for time points after termination of dosing. JF - Environmental health perspectives AU - Kodell, R L AU - Felton, R P AD - National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 155 EP - 166 VL - 92 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Animals KW - 2-Acetylaminofluorene -- administration & dosage KW - 2-Acetylaminofluorene -- toxicity KW - Cocarcinogenesis KW - Liver Neoplasms -- chemically induced KW - Mice KW - Female KW - Urinary Bladder Neoplasms -- chemically induced KW - Proportional Hazards Models KW - Carcinogens -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72447102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Two-stage+and+Weibull+models+for+carcinogenesis+applied+to+the+ED01+discontinued+dosing+data.&rft.au=Kodell%2C+R+L%3BFelton%2C+R+P&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-05-01&rft.volume=92&rft.issue=&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-09 N1 - Date created - 1991-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Environ Pathol Toxicol. 1980;3(3 Spec No):17-34 [7365379] Math Biosci. 1989 May;94(1):1-29 [2520163] J Natl Cancer Inst. 1980 Apr;64(4):977-89 [6929006] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Food Cosmet Toxicol. 1981 Jun;19(3):367-71 [7262748] Biometrics. 1982 Mar;38(1):43-58 [7082762] Biometrics. 1982 Dec;38(4):921-32 [7168795] Fundam Appl Toxicol. 1983 Sep-Oct;3(5):458-69 [6642103] Fundam Appl Toxicol. 1983 Sep-Oct;3(5):470-7 [6642104] Carcinogenesis. 1984 Apr;5(4):437-45 [6705147] Biometrics. 1984 Mar;40(1):41-50 [6733233] Fundam Appl Toxicol. 1986 Aug;7(2):183-90 [3758535] Risk Anal. 1987 Mar;7(1):109-19 [3615992] Risk Anal. 1988 Jun;8(2):223-30 [3413310] J Natl Cancer Inst. 1989 Feb 15;81(4):267-77 [2913324] Environ Health Perspect. 1989 May;81:169-88 [2667978] Toxicol Appl Pharmacol. 1990 Jun 1;104(1):79-93 [2360210] J Environ Pathol Toxicol. 1980;3(3 Spec No):35-54 [7365385] N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Delivering essential health care services in rural areas: an analysis of alternative models T2 - AHCPR pubn. no. 91-0017 AN - 59563058; 1991-1210235 AB - Analyzes programs developed by selected states and communities to convert closed or failing rural hospitals into facilities providing a limited range of services. Programs addressing low volumes of inpatient services, shortages of health care personnel, and financial distress. JF - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, May 1991. 50 pp. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 50 PB - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - United States -- Medical sector KW - Medical service, Rural -- United States KW - Hospitals -- Finance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59563058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Delivering+essential+health+care+services+in+rural+areas%3A+an+analysis+of+alternative+models&rft.title=Delivering+essential+health+care+services+in+rural+areas%3A+an+analysis+of+alternative+models&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 pa N1 - Document feature - bibl(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - From the Assistant Secretary for Health, US Public Health Service. AN - 80507948; 2013918 JF - JAMA AU - Mason, J O AD - DHHS Assistant Secretary for Health, Public Health Service. Y1 - 1991/04/24/ PY - 1991 DA - 1991 Apr 24 SP - 2049 VL - 265 IS - 16 SN - 0098-7484, 0098-7484 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Health Promotion -- organization & administration KW - Child KW - Lead Poisoning -- prevention & control KW - United States Public Health Service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80507948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Assistant+Secretary+for+Health%2C+US+Public+Health+Service.&rft.au=Mason%2C+J+O&rft.aulast=Mason&rft.aufirst=J&rft.date=1991-04-24&rft.volume=265&rft.issue=16&rft.spage=2049&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-10 N1 - Date created - 1991-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 80484698; 1848642 JF - JAMA AU - Nightingale, S L AD - Office of Health Affairs, FDA, Rockville, MD 20857. Y1 - 1991/04/10/ PY - 1991 DA - 1991 Apr 10 SP - 1802 VL - 265 IS - 14 SN - 0098-7484, 0098-7484 KW - Biological Products KW - 0 KW - Drugs, Investigational KW - Hydroxybutyrates KW - Pharmaceutical Preparations KW - Succimer KW - DX1U2629QE KW - 2-hydroxybutyric acid KW - O0ADR0I4H5 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Child KW - Lead Poisoning -- drug therapy KW - Hydroxybutyrates -- adverse effects KW - Succimer -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80484698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1991-04-10&rft.volume=265&rft.issue=14&rft.spage=1802&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline. AN - 80481125; 2005633 AB - A retrospective cohort study of the incidence of bladder cancer was conducted in response to a union request for an evaluation of a possible excess number of cases of bladder cancer at a chemical plant in western New York State. Workers at the plant were exposed to two potential bladder carcinogens--ortho-toluidine (o-toluidine) and aniline. Incidence rates of bladder cancer among workers at the plant were compared with those of the population of New York State (excluding New York City). Among all 1749 workers at the plant, 13 cases of bladder cancer were observed versus 3.61 expected [standardized incidence ratio (SIR) = 3.60; 90% confidence interval (CI) = 2.13-5.73]. Among the 708 workers who worked in areas in which o-toluidine and aniline were used, 7 cases were observed versus 1.08 expected (SIR = 6.48; 90% CI = 3.04-12.2). Among the 288 maintenance, shipping, and janitorial workers thought to have been possibly exposed, 4 cases were observed versus 1.09 expected (SIR = 3.66; 90% CI = 1.25-8.37). Among the remaining 753 workers who were probably not exposed, 2 bladder cancers were observed versus 1.43 expected (SIR = 1.39; 90% CI = 0.25-4.39). Increased risk of bladder cancer was strongly associated with increased duration of employment in the department where o-toluidine and aniline were used (P less than .001). Among workers with 10 or more years of employment in the department, the SIR was 27.2 (90% CI = 11.8-53.7). o-Toluidine is an animal carcinogen more potent than aniline and is known to produce bladder tumors in rats; hence, it is more likely that o-toluidine is responsible for the observed excess number of cases of bladder cancer, although aniline may have played a role. JF - Journal of the National Cancer Institute AU - Ward, E AU - Carpenter, A AU - Markowitz, S AU - Roberts, D AU - Halperin, W AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/04/03/ PY - 1991 DA - 1991 Apr 03 SP - 501 EP - 506 VL - 83 IS - 7 SN - 0027-8874, 0027-8874 KW - Aniline Compounds KW - 0 KW - Toluidines KW - 2-toluidine KW - B635MZ0ZLU KW - aniline KW - SIR7XX2F1K KW - Index Medicus KW - Occupational Exposure KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Retrospective Studies KW - Smoking -- adverse effects KW - Aged KW - Middle Aged KW - Male KW - Female KW - Urinary Bladder Neoplasms -- epidemiology KW - Aniline Compounds -- toxicity KW - Urinary Bladder Neoplasms -- chemically induced KW - Toluidines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80481125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Excess+number+of+bladder+cancers+in+workers+exposed+to+ortho-toluidine+and+aniline.&rft.au=Ward%2C+E%3BCarpenter%2C+A%3BMarkowitz%2C+S%3BRoberts%2C+D%3BHalperin%2C+W&rft.aulast=Ward&rft.aufirst=E&rft.date=1991-04-03&rft.volume=83&rft.issue=7&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-19 N1 - Date created - 1991-04-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 1994 Jan 5;86(1):59-62 [8271286] J Natl Cancer Inst. 1991 Nov 20;83(22):1686-7 [1749022] J Natl Cancer Inst. 1991 Oct 16;83(20):1507-8 [1920498] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Work posture, workstation design, and musculoskeletal discomfort in a VDT data entry task. AN - 80709668; 1860702 AB - Self-report data on musculoskeletal discomfort were collected from several hundred VDT users in two agencies of a state government. Aspects of worker posture and workstation design were objectively assessed for 40 of the VDT users. Multiple regression analyses were used to examine the relationship between these ergonomic variables and musculoskeletal discomfort. Effects of ergonomic factors on musculoskeletal discomfort were clearly evident in the analyses. Regression models explained up to 38% of the variance in discomfort at different body sites. Of special interest was that leg discomfort increased with low, soft seat pans, suggesting that postural constraint is more important than thigh compression as a risk factor for leg discomfort in VDT work. In addition, arm discomfort increased with increases in keyboard height above elbow level, supporting arguments for low placement of the keyboard. Finally, high levels of neck and shoulder girdle discomfort observed in the study population suggest the need for further attention to the control of cervicobrachial pain syndromes in VDT work. JF - Human factors AU - Sauter, S L AU - Schleifer, L M AU - Knutson, S J AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 151 EP - 167 VL - 33 IS - 2 SN - 0018-7208, 0018-7208 KW - Index Medicus KW - Space life sciences KW - Risk Factors KW - Humans KW - Brachial Plexus Neuritis -- physiopathology KW - Adult KW - Cumulative Trauma Disorders -- physiopathology KW - Male KW - Female KW - Pain -- physiopathology KW - Computer Terminals KW - Occupational Diseases -- physiopathology KW - Posture -- physiology KW - Muscles -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80709668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+factors&rft.atitle=Work+posture%2C+workstation+design%2C+and+musculoskeletal+discomfort+in+a+VDT+data+entry+task.&rft.au=Sauter%2C+S+L%3BSchleifer%2C+L+M%3BKnutson%2C+S+J&rft.aulast=Sauter&rft.aufirst=S&rft.date=1991-04-01&rft.volume=33&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Human+factors&rft.issn=00187208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-04 N1 - Date created - 1991-09-04 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse. AN - 80704101; 1855627 AB - An embryotoxic oral dose of bis(2-methoxyethyl) ether (DGDME), 3.73 mmol/kg body wt (500 mg/kg), administered on the 11th day of gestation to pregnant CD-1 mice was metabolized predominantly by O-demethylation to 2-(2-methoxyethoxy)ethanol with subsequent oxidation to (2-methoxyethoxy)acetic acid. Urinary excretion of this metabolite over 48 hr amounted to 63 +/- 2% of the dose. A smaller percentage of the administered dose was metabolized at the central ether linkage to produce 2-methoxyethanol, which was further metabolized by alcohol dehydrogenase to methoxyacetic acid. Urinary excretion of methoxyacetic acid, a potent developmental toxicant, amounted to 28 +/- 1% of the administered dose by 48 hr and was the second most prominent urinary metabolite. Unchanged DGDME and methoxyacetic acid were detected in the embryonic tissues from these animals, and embryos harvested after the initial 6-hr period showed detectable amounts of only methoxyacetic acid. The average amount of methoxyacetic acid per embryo was calculated to be 1.5 +/- 1.0 mumol (5.9 mmol/kg body wt) at the 6-hr termination time. This finding suggests that the reported teratogenic effects of DGDME are due to methoxyacetic acid formed, either in the fetus or by hepatic metabolism in the dam with subsequent distribution to the embryonic tissue. These results suggest that such developmental toxicity may occur with structurally similar aprotic ethylene glycol ethers in which metabolic O-dearylation would yield 2-methoxy-ethanol. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Daniel, F B AU - Cheever, K L AU - Begley, K B AU - Richards, D E AU - Weigel, W W AU - Eisenmann, C J AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 567 EP - 575 VL - 16 IS - 3 SN - 0272-0590, 0272-0590 KW - Ethylene Glycols KW - 0 KW - Methyl Ethers KW - Teratogens KW - diglyme KW - M4BH3X0MVZ KW - Index Medicus KW - Mice, Inbred Strains KW - Mass Spectrometry KW - Animals KW - Mice KW - Female KW - Chromatography, High Pressure Liquid KW - Pregnancy KW - Teratogens -- metabolism KW - Methyl Ethers -- metabolism KW - Fetus -- drug effects KW - Ethylene Glycols -- toxicity KW - Ethylene Glycols -- metabolism KW - Methyl Ethers -- toxicity KW - Fetus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80704101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Bis%282-methoxyethyl%29+ether%3A+metabolism+and+embryonic+disposition+of+a+developmental+toxicant+in+the+pregnant+CD-1+mouse.&rft.au=Daniel%2C+F+B%3BCheever%2C+K+L%3BBegley%2C+K+B%3BRichards%2C+D+E%3BWeigel%2C+W+W%3BEisenmann%2C+C+J&rft.aulast=Daniel&rft.aufirst=F&rft.date=1991-04-01&rft.volume=16&rft.issue=3&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-29 N1 - Date created - 1991-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of epidemiology data to assess the cancer risk of 2,3,7,8-tetrachlorodibenzo-p-dioxin. AN - 80691332; 1852927 AB - Most countries have assessed the human cancer risk of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by extrapolating from animal data. The 1600-fold variation for acceptable intakes estimated by the Americans, Canadians, and Europeans, however, indicates a large scientific uncertainty about TCDD toxicity. Regulators are attempting to use human epidemiology data to eliminate some of the limitations inherent in using animal data to quantitatively assess cancer risk in humans, particularly now that techniques for measuring TCDD levels in adipose tissue and serum are available. This paper presents an overview of the major epidemiologic studies that associate cancer with TCDD exposure. The actual exposures experienced by the study populations are emphasized. The TCDD serum levels of the Seveso, Italy, residents and of the NIOSH Dioxin Registry participants indicate that these populations hold the best promise for future assessment of the human carcinogenic risk of dioxin. Based on the animal data, however, the calculated risk from these exposures is still moderate compared with high background cancer incidence present in most industrialized countries. JF - Regulatory toxicology and pharmacology : RTP AU - Tollefson, L AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 150 EP - 169 VL - 13 IS - 2 SN - 0273-2300, 0273-2300 KW - Polychlorinated Dibenzodioxins KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Neoplasms -- chemically induced KW - Polychlorinated Dibenzodioxins -- toxicity KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80691332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Use+of+epidemiology+data+to+assess+the+cancer+risk+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Tollefson%2C+L&rft.aulast=Tollefson&rft.aufirst=L&rft.date=1991-04-01&rft.volume=13&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-20 N1 - Date created - 1991-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An overview of process hazard evaluation techniques. AN - 80671949; 2069123 AB - Since the 1985 release of methyl isocyanate in Bhopal, India, which killed thousands, the chemical industry has begun to use process hazard analysis techniques more widely to protect the public from catastrophic chemical releases. These techniques can provide a systematic method for evaluating a system design to ensure that it operates as intended, help identify process areas that may result in the release of a hazardous chemical, and help suggest modifications to improve process safety. Eight different techniques are discussed, with some simple examples of how they might be applied. These techniques include checklists, "what if" analysis, safety audits and reviews, preliminary hazard analysis (PHA), failure modes and effect analysis (FMEA), fault tree analysis (FTA), event tree analysis (ETA), and hazard and operability studies (HAZOP). The techniques vary in sophistication and scope, and no single one will always be the best. These techniques can also provide the industrial hygienist with the tools needed to protect both workers and the community from both major and small-scale chemical releases. A typical industrial hygiene evaluation of a facility would normally include air sampling. If the air sampling does detect a specific hazardous substance, the source will probably be a routine or continuous emission. However, air sampling will not be able to identify or predict the location of a nonroutine emission reliably. By incorporating these techniques with typical evaluations, however, industrial hygienists can proactively help reduce the hazards to the workers they serve. JF - American Industrial Hygiene Association journal AU - Gressel, M G AU - Gideon, J A AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 158 EP - 163 VL - 52 IS - 4 SN - 0002-8894, 0002-8894 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Evaluation Studies as Topic KW - Occupational Health KW - Decision Trees KW - Hazardous Substances -- analysis KW - Decision Support Techniques KW - Disaster Planning KW - Accident Prevention KW - Chemical Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80671949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=An+overview+of+process+hazard+evaluation+techniques.&rft.au=Gressel%2C+M+G%3BGideon%2C+J+A&rft.aulast=Gressel&rft.aufirst=M&rft.date=1991-04-01&rft.volume=52&rft.issue=4&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-13 N1 - Date created - 1991-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interleukin-2 toxicity. AN - 80666609; 2066765 AB - Because of the ability of interleukin-2 (IL-2) to support the proliferation and activation of numerous types of immunocompetent cells and to support the survival of adoptively transferred lymphocytes, there has been considerable interest in its use in the immunotherapy of malignancies. While studies to date have indicated that IL-2 has activity against some malignancies, considerable toxicity has also been observed. Careful prescreening and selection of patients and appropriate management of toxicity can minimize adverse outcomes. Studies of IL-2 effects have provided intriguing evidence of interactions of the immune/cytokine system with the neuroendocrine, cardiovascular, and other systems. Studies in animal models have demonstrated the central role of an intact immune system in mediating many toxicities of IL-2. Several adverse effects of IL-2 appear to be mediated by other cytokines whose production is induced by IL-2. Studies into the pathogenesis and manifestations of IL-2 toxicity have offered the hope of developing less toxic approaches to IL-2 therapy. Several lessons from the IL-2 experience are likely to be applicable in the clinical development of other cytokines. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Siegel, J P AU - Puri, R K AD - Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 694 EP - 704 VL - 9 IS - 4 SN - 0732-183X, 0732-183X KW - Interleukin-2 KW - 0 KW - Index Medicus KW - Syndrome KW - Humans KW - Capillary Permeability -- drug effects KW - Interleukin-2 -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80666609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Interleukin-2+toxicity.&rft.au=Siegel%2C+J+P%3BPuri%2C+R+K&rft.aulast=Siegel&rft.aufirst=J&rft.date=1991-04-01&rft.volume=9&rft.issue=4&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 ER - TY - JOUR T1 - An epidemic of dermatitis at a large construction site. AN - 80573613; 1828081 AB - During 6 months in 1986, an epidemic of dermatitis occurred among more than 5600 workers at a single large construction site in the United States. To identify its cause, we used the monthly nurses' log of visits to the medical facility to characterize the outbreak by person, place, and time. Follow-up studies included a survey of carpenters and skin testing of laboratory animals. Workers were more than twice as likely to visit the medical facility for a skin-related complaint in 1986 compared with 1985 (relative rate [RR] = 2.6, 95% confidence interval [CI] 2.2-3.2). Carpenters experienced the greatest increased risk (RR = 9.7, 95% CI 5.5-17.3). We found a strong association between dermatitis and handling of fire-retardant lumber and plywood. Carpenters working only with fire-retardant lumber had a rate of dermatitis 4 times that of carpenters who worked exclusively with untreated wood (RR = 3.6, 95% CI 1.5-8.6). Carpenters who occasionally worked with fire-retardant lumber and plywood were at moderate risk (RR = 2.18, 95% CI 0.7-6.7). Although laboratory tests showed that phosphate compounds could be leached with water from the fire-retardant wood, an extract of these phosphates did not irritate the skin of laboratory animals. We concluded the epidemic was a result of handling fire-retardant lumber but could not identify the specific chemical agent. In view of the observed association, construction workers should be advised to handle this material with caution, especially in high temperature and humidity. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Sinks, T AU - O'Malley, M AU - Hartle, R AU - Hales, T R AU - Ruhe, R AD - DSHEFS, NIOSH, Cincinnati, OH 45226. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 462 EP - 467 VL - 33 IS - 4 SN - 0096-1736, 0096-1736 KW - Flame Retardants KW - 0 KW - Index Medicus KW - Cross-Sectional Studies KW - Animals KW - Humans KW - Chi-Square Distribution KW - Surveys and Questionnaires KW - Confidence Intervals KW - Rabbits KW - Follow-Up Studies KW - United States -- epidemiology KW - Male KW - Female KW - Construction Materials -- adverse effects KW - Flame Retardants -- adverse effects KW - Wood KW - Flame Retardants -- toxicity KW - Dermatitis, Occupational -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80573613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=An+epidemic+of+dermatitis+at+a+large+construction+site.&rft.au=Sinks%2C+T%3BO%27Malley%2C+M%3BHartle%2C+R%3BHales%2C+T+R%3BRuhe%2C+R&rft.aulast=Sinks&rft.aufirst=T&rft.date=1991-04-01&rft.volume=33&rft.issue=4&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-03 N1 - Date created - 1991-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interactions of MK-801 with glutamate-, glutamine- and methamphetamine-evoked release of [3H]dopamine from striatal slices. AN - 80525052; 1673475 AB - The interactions of MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine], glutamate and glutamine with methamphetamine (METH)-evoked release of [3H]dopamine were assessed in vitro to determine whether MK-801 inhibition of METH neurotoxicity might be mediated presynaptically, and to evaluate the effects of glutamatergic stimulation on METH-evoked dopamine release. MK-801 inhibition of glutamate- or METH-evoked dopamine release might reduce synaptic dopamine levels during METH exposure and decrease the formation of 6-hydroxydopamine or other related neurotoxins. Without Mg++ present, 40 microM and 1 mM glutamate evoked a N-methyl-D-aspartate receptor-mediated [3H]dopamine and [3H]metabolite (tritium) release of 3 to 6 and 12 to 16% of total tritium stores, respectively, from striatal slices. With 1.50 mM Mg++ present, 10 mM glutamate alone or in combination with the dopamine uptake blocker nomifensine released only 2.1 or 4.2%, respectively, of total tritium stores, and release was only partially dependent on N-methyl-D-aspartate-type glutamate receptors. With or without 1.50 mM Mg++ present, 0.5 or 5 microM METH evoked a substantial release of tritium (5-8 or 12-21% of total stores, respectively). METH-evoked dopamine release was not affected by 5 microM MK-801 but METH-evoked release was additive with glutamate-evoked release. Without Mg++ present, 1 mM glutamine increased glutamate release and induced the release of [3H]dopamine and metabolites. Both 0.5 and 5 microM METH also increased tritium release with 1 mM glutamine present. When striatal slices were exposed to 5 microM METH this glutamine-evoked release of glutamate was increased more than 50%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Bowyer, J F AU - Scallet, A C AU - Holson, R R AU - Lipe, G W AU - Slikker, W AU - Ali, S F AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 262 EP - 270 VL - 257 IS - 1 SN - 0022-3565, 0022-3565 KW - Glutamates KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Glutamine KW - 0RH81L854J KW - Tritium KW - 10028-17-8 KW - Nomifensine KW - 1LGS5JRP31 KW - Glutamic Acid KW - 3KX376GY7L KW - Methamphetamine KW - 44RAL3456C KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Magnesium KW - I38ZP9992A KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - In Vitro Techniques KW - Magnesium -- pharmacology KW - Nomifensine -- pharmacology KW - Male KW - Dopamine -- secretion KW - Corpus Striatum -- secretion KW - Glutamine -- pharmacology KW - Glutamates -- pharmacology KW - Methamphetamine -- toxicity KW - Dizocilpine Maleate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80525052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Interactions+of+MK-801+with+glutamate-%2C+glutamine-+and+methamphetamine-evoked+release+of+%5B3H%5Ddopamine+from+striatal+slices.&rft.au=Bowyer%2C+J+F%3BScallet%2C+A+C%3BHolson%2C+R+R%3BLipe%2C+G+W%3BSlikker%2C+W%3BAli%2C+S+F&rft.aulast=Bowyer&rft.aufirst=J&rft.date=1991-04-01&rft.volume=257&rft.issue=1&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-24 N1 - Date created - 1991-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Formation of C8-modified deoxyguanosine and C8-modified deoxyadenosine as major DNA adducts from 2-nitropyrene metabolism mediated by rat and mouse liver microsomes and cytosols. AN - 80499906; 2013125 AB - 2-Nitropyrene, the geometric isomer of the most studied nitropolycyclic aromatic hydrocarbon (nitro-PAH), 1-nitropyrene, is an environmental contaminant detected in ambient air and a potent direct-acting mutagen. Its metabolic activation leading to the formation of DNA adducts was studied. The activated metabolite, N-hydroxy-2-aminopyrene, was prepared and reacted with calf thymus DNA. Upon enzymatic hydrolysis of the DNA, the resulting nucleosides were separated by HPLC, and the adducts were characterized by mass and proton NMR spectral analysis. Both N-(deoxyguanosin-8-yl)-2-aminopyrene and N-(deoxyadenosin-8-yl)-2-aminopyrene, in a 5:2 ratio, were identified. These adducts were then utilized as standards to identify the DNA adducts formed from reaction of [3H]2-nitropyrene with DNA mediated by liver microsomes and cytosols of mouse and rat. In all cases, both adducts were formed. The quantities of the two adducts formed in each system were: mouse liver microsomes (11.3 pmol [3H]2-nitropyrene/mg DNA), rat liver microsomes (23), mouse liver cytosol (11.4) and rat liver cytosol (5.1). Thus, these adducts were formed in highest yield from rat liver microsomes and the lowest from rat liver cytosol. The deoxyguanosine/deoxyadenosine adduct ratio was higher from rat and mouse liver microsomes (7.8:9.2) than from rat and mouse liver cytosols (2.5:3.1). Our results represent the first direct demonstration of a C8-deoxyadenosine adduct being formed as a major product from the reaction of a nitro-PAH metabolite with DNA. JF - Carcinogenesis AU - Fu, P P AU - Miller, D W AU - Von Tungeln, L S AU - Bryant, M S AU - Lay, J O AU - Huang, K AU - Jones, L AU - Evans, F E AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 609 EP - 616 VL - 12 IS - 4 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Deoxyadenosines KW - Pyrenes KW - Tritium KW - 10028-17-8 KW - N-(deoxyguanosin-8-yl)-2-aminopyrene KW - 134249-04-0 KW - N-(deoxyadenosin-8-yl)-2-aminopyrene KW - 134249-05-1 KW - 2-nitropyrene KW - 789-07-1 KW - N-hydroxy-2-aminopyrene KW - 85964-28-9 KW - DNA KW - 9007-49-2 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Liver -- ultrastructure KW - Mice, Inbred Strains KW - Animals KW - Carcinogens -- metabolism KW - Liver -- drug effects KW - Thymus Gland -- metabolism KW - Liver -- metabolism KW - Mice KW - Male KW - Pyrenes -- toxicity KW - Cytosol -- metabolism KW - Deoxyguanosine -- metabolism KW - Microsomes, Liver -- metabolism KW - DNA -- metabolism KW - Pyrenes -- metabolism KW - Deoxyadenosines -- metabolism KW - Pyrenes -- chemical synthesis KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80499906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Formation+of+C8-modified+deoxyguanosine+and+C8-modified+deoxyadenosine+as+major+DNA+adducts+from+2-nitropyrene+metabolism+mediated+by+rat+and+mouse+liver+microsomes+and+cytosols.&rft.au=Fu%2C+P+P%3BMiller%2C+D+W%3BVon+Tungeln%2C+L+S%3BBryant%2C+M+S%3BLay%2C+J+O%3BHuang%2C+K%3BJones%2C+L%3BEvans%2C+F+E&rft.aulast=Fu&rft.aufirst=P&rft.date=1991-04-01&rft.volume=12&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-14 N1 - Date created - 1991-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Second cancers following non-Hodgkin's lymphoma. AN - 80478753; 2004317 AB - The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed/expected [O/E] = 1.18; O = 1231). The O/E ratio increased significantly with time to reach 1.77 in 10-year survivors. Significant excesses were noted for acute nonlymphocytic leukemia (O/E = 2.88), cancers of the bladder (O/E = 1.30), kidney (O/E = 1.47), and lung (O/E = 1.57), malignant melanoma (O/E = 2.44), and Hodgkin's disease (O/E = 4.16). Chemotherapy appeared related to subsequent acute nonlymphocytic leukemia (ANLL) and bladder cancer. Radiation therapy was associated with ANLL and possibly cancers of the lung, bladder, and bone. Malignant melanoma was not clearly related to initial NHL treatment. JF - Cancer AU - Travis, L B AU - Curtis, R E AU - Boice, J D AU - Hankey, B F AU - Fraumeni, J F AD - Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Y1 - 1991/04/01/ PY - 1991 DA - 1991 Apr 01 SP - 2002 EP - 2009 VL - 67 IS - 7 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Staging KW - Neoplasms, Radiation-Induced -- pathology KW - Combined Modality Therapy KW - Risk Factors KW - Neoplasms, Radiation-Induced -- epidemiology KW - Humans KW - Incidence KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Antineoplastic Agents -- adverse effects KW - Neoplasms, Multiple Primary -- etiology KW - Neoplasms, Multiple Primary -- pathology KW - Neoplasms, Multiple Primary -- epidemiology KW - Lymphoma, Non-Hodgkin -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80478753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Second+cancers+following+non-Hodgkin%27s+lymphoma.&rft.au=Travis%2C+L+B%3BCurtis%2C+R+E%3BBoice%2C+J+D%3BHankey%2C+B+F%3BFraumeni%2C+J+F&rft.aulast=Travis&rft.aufirst=L&rft.date=1991-04-01&rft.volume=67&rft.issue=7&rft.spage=2002&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-22 N1 - Date created - 1991-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acridine orange stain for determining intracellular enteropathogens in HeLa cells. AN - 72086226; 1716265 AB - Green-fluorescent intracellular enteropathogenic bacteria were observed after infected HeLa cell monolayers were stained with acridine orange and counterstained with crystal violet at least 3 h after infection. JF - Journal of clinical microbiology AU - Miliotis, M D AD - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 830 EP - 831 VL - 29 IS - 4 SN - 0095-1137, 0095-1137 KW - Fluorescent Dyes KW - 0 KW - Acridine Orange KW - F30N4O6XVV KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Humans KW - Enterobacteriaceae Infections -- diagnosis KW - HeLa Cells -- microbiology KW - Staining and Labeling KW - Enterobacteriaceae -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72086226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Acridine+orange+stain+for+determining+intracellular+enteropathogens+in+HeLa+cells.&rft.au=Miliotis%2C+M+D&rft.aulast=Miliotis&rft.aufirst=M&rft.date=1991-04-01&rft.volume=29&rft.issue=4&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-15 N1 - Date created - 1991-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1983 Apr;40(1):340-50 [6299962] Scand J Infect Dis Suppl. 1980;Suppl 24:86-92 [6111123] Infect Immun. 1979 Jun;24(3):879-86 [381204] S Afr Med J. 1978 Jan 21;53(3):93-4 [349716] Infect Immun. 1977 Aug;17(2):290-5 [330403] Can J Microbiol. 1977 Dec;23(12):1714-22 [597794] Infect Immun. 1976 Oct;14(4):851-7 [791864] J Clin Invest. 1973 Feb;52(2):441-53 [4630603] J Infect Dis. 1973 Jul;128(1):69-75 [4577975] Infect Immun. 1973 Sep;8(3):322-8 [4581006] N Engl J Med. 1971 Jul 1;285(1):1-9 [4996788] Jpn J Med Sci Biol. 1968 Oct;21(5):333-49 [4886582] J Bacteriol. 1964 Nov;88(5):1503-18 [16562000] Infect Immun. 1989 Jul;57(7):1928-35 [2659527] Infect Immun. 1987 Nov;55(11):2681-8 [3312007] J Clin Microbiol. 1985 Dec;22(6):897-902 [4066921] J Lab Clin Med. 1983 Aug;102(2):298-305 [6864075] Infect Immun. 1982 Mar;35(3):852-60 [6279518] Infect Immun. 1983 Feb;39(2):505-13 [6187681] J Med Microbiol. 1983 Feb;16(1):37-43 [6337262] N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Current intelligence bulletin 55. Carcinogenicity of acetaldehyde and malonaldehyde, and mutagenicity of related low-molecular-weight aldehydes. AN - 16235483; 2768926 AB - The National Institute for Occupational Safety and Health (NIOSH) has determined that acetaldehyde and malonaldehyde are potentially carcinogenic to occupationally exposed workers. NIOSH is also concerned about exposure to nine related low-molecular-weight aldehydes: acrolein, butyraldehyde, crotonaldehyde, glutaraldehyde, glyoxal, paraformaldehyde, propiolaldehyde, propionaldehyde, and valeraldehyde. Long-term inhalation studies of acetaldehyde produced laryngeal cancers in hamsters and nasal cancers in rats. JF - NTIS, SPRINGFIELD, VA (USA). 1991. Y1 - 1991/04// PY - 1991 DA - Apr 1991 PB - NTIS, SPRINGFIELD, VA (USA) KW - acetaldehyde KW - malonaldehyde KW - Health & Safety Science Abstracts; Risk Abstracts KW - carcinogenicity KW - mutagenicity KW - aldehydes KW - occupational exposure KW - R2 23080:Industrial and labor KW - H SI0.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16235483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Current+intelligence+bulletin+55.+Carcinogenicity+of+acetaldehyde+and+malonaldehyde%2C+and+mutagenicity+of+related+low-molecular-weight+aldehydes.&rft.title=Current+intelligence+bulletin+55.+Carcinogenicity+of+acetaldehyde+and+malonaldehyde%2C+and+mutagenicity+of+related+low-molecular-weight+aldehydes.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - NTIS Order No.: PB92-131697/GAR. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Video display terminals and the risk of spontaneous abortion. AN - 80457934; 1997838 AB - The relation between spontaneous abortion and the use of video display terminals (VDTs) is of great public health concern. Previous investigators of this issue have reported inconsistent findings. To determine whether electromagnetic fields emitted by VDTs are associated with an increased risk of spontaneous abortion, a cohort of female telephone operators who used VDTs at work was compared with a cohort of operators who did not use VDTs. To obtain reliable estimates of exposure, we determined the number of hours of VDT use per week from company records and measured electromagnetic fields at VDT workstations and, for purposes of comparison, at workstations without VDTs. Operators who used VDTs had higher abdominal exposure to very-low-frequency (15 kHz) electromagnetic fields (workstations without VDTs did not emit very-low-frequency energy). Abdominal exposure to extremely-low-frequency fields (45 to 60 Hz) was similar for both operators who used VDTs and those who did not. Among 2430 women interviewed, there were 882 pregnancies that met our criteria for inclusion in the study. We found no excess risk of spontaneous abortion among women who used VDTs during the first trimester of pregnancy (odds ratio = 0.93; 95 percent confidence interval, 0.63 to 1.38), and no dose-response relation was apparent when we examined the women's hours of VDT use per week (odds ratio for 1 to 25 hours per week = 1.04; 95 percent confidence interval, 0.61 to 1.79; odds ratio for greater than 25 hours per week = 1.00; 95 percent confidence interval, 0.61 to 1.64). There continued to be no risk associated with the use of VDTs when we accounted for multiple pregnancies, conducted separate analyses of early abortion, late abortion, and all fetal losses, or limited our analyses to spontaneous abortions for which a physician was consulted. The use of VDTs and exposure to the accompanying electromagnetic fields were not associated with an increased risk of spontaneous abortion in this study. JF - The New England journal of medicine AU - Schnorr, T M AU - Grajewski, B A AU - Hornung, R W AU - Thun, M J AU - Egeland, G M AU - Murray, W E AU - Conover, D L AU - Halperin, W E AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/03/14/ PY - 1991 DA - 1991 Mar 14 SP - 727 EP - 733 VL - 324 IS - 11 SN - 0028-4793, 0028-4793 KW - Abridged Index Medicus KW - Index Medicus KW - Regression Analysis KW - Electromagnetic Fields KW - Logistic Models KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Female KW - Pregnancy KW - Fetal Death KW - Occupational Exposure KW - Abortion, Spontaneous -- etiology KW - Computer Terminals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80457934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Video+display+terminals+and+the+risk+of+spontaneous+abortion.&rft.au=Schnorr%2C+T+M%3BGrajewski%2C+B+A%3BHornung%2C+R+W%3BThun%2C+M+J%3BEgeland%2C+G+M%3BMurray%2C+W+E%3BConover%2C+D+L%3BHalperin%2C+W+E&rft.aulast=Schnorr&rft.aufirst=T&rft.date=1991-03-14&rft.volume=324&rft.issue=11&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-01 N1 - Date created - 1991-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Sep 12;325(11):811-3 [1870658] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spina bifida in infants of women treated with carbamazepine during pregnancy. AN - 80444321; 1994251 JF - The New England journal of medicine AU - Rosa, F W AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD. Y1 - 1991/03/07/ PY - 1991 DA - 1991 Mar 07 SP - 674 EP - 677 VL - 324 IS - 10 SN - 0028-4793, 0028-4793 KW - Anticonvulsants KW - 0 KW - Carbamazepine KW - 33CM23913M KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Cohort Studies KW - Infant, Newborn KW - Anticonvulsants -- adverse effects KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Carbamazepine -- adverse effects KW - Spinal Dysraphism -- chemically induced KW - Pregnancy Complications -- drug therapy KW - Epilepsy -- drug therapy KW - Abnormalities, Drug-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80444321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Spina+bifida+in+infants+of+women+treated+with+carbamazepine+during+pregnancy.&rft.au=Rosa%2C+F+W&rft.aulast=Rosa&rft.aufirst=F&rft.date=1991-03-07&rft.volume=324&rft.issue=10&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-21 N1 - Date created - 1991-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Mar 7;324(10):690-1 [1994254] N Engl J Med. 1991 Aug 29;325(9):664-5 [1861708] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fumigants and related chemicals in foods: review of residue findings, contamination sources, and analytical methods. AN - 80653299; 2063187 AB - Public concern over chemical residues in foods increased in the United States during the early 1980s. Potentially hazardous levels of ethylene dibromide (EDB), a relatively non-volatile fumigant, were detected in several finished grain-based products by governmental food-monitoring laboratories. As a result, the U.S. Environmental Protection Agency banned the use of EDB as a fumigant in 1983. Commercial fumigators then began using more of the highly volatile chemicals such as methyl bromide and phosphine. These chemicals are less likely to leave residues on stored crops than the previously used fumigants such as EDB, chloroform, and carbon tetrachloride. However, trace residues of many pest-control fumigants and related industrial chemicals are currently found in assorted foods. This contamination may come from the original fumigation of stored crops, or from the industrial chemicals occurring in the environment and in food processing chains. No potential health problem is indicated at this time. Yet scientists continue to uncover the sources of this chemical contamination, and to develop better methods to monitor foods for it. They also seek better ways to protect foodstuffs from pests prior to human consumption. JF - The Science of the total environment AU - Daft, J L AD - US Department of Health and Human Service, Food and Drug Administration, Kansas City, MO 64106. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 501 EP - 518 VL - 100 Spec No SN - 0048-9697, 0048-9697 KW - Solvents KW - 0 KW - Ethylene Dibromide KW - 1N41638RNO KW - Index Medicus KW - United States KW - Solvents -- toxicity KW - United States Environmental Protection Agency KW - Humans KW - Food Analysis KW - Food Handling KW - Ethylene Dibromide -- toxicity KW - Food Contamination KW - Fumigation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80653299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Fumigants+and+related+chemicals+in+foods%3A+review+of+residue+findings%2C+contamination+sources%2C+and+analytical+methods.&rft.au=Daft%2C+J+L&rft.aulast=Daft&rft.aufirst=J&rft.date=1991-03-01&rft.volume=100+Spec+No&rft.issue=&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=00489697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-05 N1 - Date created - 1991-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung particulate burdens of subjects from the Cincinnati, Ohio urban area. AN - 80628084; 1647057 AB - Because of the relatively small data base existing for lung particulate burdens of subjects with no overt pneumoconioses, the total exogenous lung particulate concentrations of 91 subjects from the Cincinnati, Ohio urban area were determined using an automated scanning electron microscope-energy dispersive x-ray analysis-image analysis system. Four of these subjects were foundry workers and had the highest exogenous particle concentrations seen in the 91 lungs, ranging from 1860 to 2990 x 10(6) particles per gram of dry lung (ppg). The average exogenous particle concentration for the remaining 87 subjects was 476 +/- 380 x 10(6) ppg with a range of 71 to 1860 x 10(6) ppg. The median size of the exogenous particles in the 87 lungs was narrow, ranging from 0.37 to 1.02 microns. The geometric mean particle size over all 87 lungs was 0.60 microns with a geometric standard deviation (sigma g) of 2.35. The total exogenous particle levels were elevated for the male subjects compared to females (p=0.015), and were positively associated with age (p=0.021). However, no correlation was seen between total particle concentration and race or smoking history. JF - Scanning microscopy AU - Stettler, L E AU - Platek, S F AU - Riley, R D AU - Mastin, J P AU - Simon, S D AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 85 EP - 92; discussion 92-4 VL - 5 IS - 1 SN - 0891-7035, 0891-7035 KW - Coal KW - 0 KW - Dust KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Pneumoconiosis -- etiology KW - Particle Size KW - Humans KW - Pneumoconiosis -- epidemiology KW - Ohio -- epidemiology KW - Aged KW - Smoking KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Mining KW - Urban Population KW - Female KW - Male KW - Microscopy, Electron, Scanning KW - Lung -- chemistry KW - Lung -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80628084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+microscopy&rft.atitle=Lung+particulate+burdens+of+subjects+from+the+Cincinnati%2C+Ohio+urban+area.&rft.au=Stettler%2C+L+E%3BPlatek%2C+S+F%3BRiley%2C+R+D%3BMastin%2C+J+P%3BSimon%2C+S+D&rft.aulast=Stettler&rft.aufirst=L&rft.date=1991-03-01&rft.volume=5&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Scanning+microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of benzene in polypropylene food-packaging materials and food-contact paraffin waxes. AN - 80621124; 2050616 AB - An analytical procedure was developed for determination of benzene in polypropylene food packaging and was adapted for determination of benzene in commercial paraffin waxes intended for food-contact use. The polymer was dissolved in hexadecane at 150 degrees C. The wax was melted in an 80 degrees C oven. A simple helium-sparging apparatus was used to remove the volatile chemical from the polymer or wax. The contaminant was collected in methanol, distilled water was added, and the resulting solution was analyzed by headspace gas chromatography. The instrument was equipped with a 30 m fused silica open tubular capillary column and a photoionization detector. Average recoveries of benzene from polymer and paraffin wax at low parts-per-billion concentrations were 63 and 70%, respectively. Limits of detection and quantitation for analysis of polypropylene were 8 and 17 ppb, respectively; the limit of quantitation for analysis of paraffin wax was 2 ppb. In several commercial polypropylene products examined, benzene levels ranged from none detected to 426 ppb. In 3 commercial waxes examined, concentrations of 16-73 ppb benzene were determined. The presence of benzene was confirmed by gas chromatography/mass spectrometry. JF - Journal - Association of Official Analytical Chemists AU - Varner, S L AU - Hollifield, H C AU - Andrzejewski, D AD - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204. PY - 1991 SP - 367 EP - 374 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Polypropylenes KW - 0 KW - Paraffin KW - 8002-74-2 KW - Benzene KW - J64922108F KW - Index Medicus KW - Spectrophotometry, Infrared KW - Reference Standards KW - Gas Chromatography-Mass Spectrometry KW - Food Contamination -- prevention & control KW - Benzene -- analysis KW - Polypropylenes -- analysis KW - Paraffin -- analysis KW - Food Handling -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80621124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Determination+of+benzene+in+polypropylene+food-packaging+materials+and+food-contact+paraffin+waxes.&rft.au=Varner%2C+S+L%3BHollifield%2C+H+C%3BAndrzejewski%2C+D&rft.aulast=Varner&rft.aufirst=S&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food and Drug Administration pesticide residue monitoring of foods: 1983-1986. AN - 80619811; 2050609 AB - Pesticide residues in foods are reported for the 4-year period 1982-1986 [fiscal years (FY) 83-86]. Results were summarized from the 2 complementary approaches that make up the Food and Drug Administration's (FDA) pesticide residue monitoring program. Under regulatory monitoring, which focuses on residues in raw agricultural commodities, a total of 49,055 samples (27,700 domestic and 21,355 import) that included fresh fruits and vegetables, grains and grain products, milk and dairy products, seafoods, and a variety of processed foods were analyzed. No residues were found in 60 and 48% of the domestic and import samples, respectively, compared with 55 and 44% in FY78-82. About 3% of the domestic and 5% of the import samples were violative. In FY78-82, about 3 and 7% were violative, respectively. The other FDA monitoring approach, the Total Diet Study, was revised in April 1982 to expand coverage of age/sex groups, use updated diets, and provide for analysis of individual foods. Results from monitoring under this modified approach and from regulatory monitoring continued to demonstrate that pesticide residues in the U.S. food supply were well below regulatory limits, and dietary intakes were many times lower than the Acceptable Daily Intakes established by international agencies. JF - Journal - Association of Official Analytical Chemists AU - Yess, N J AU - Houston, M G AU - Gunderson, E L AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 273 EP - 280 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Data Collection -- methods KW - Diet KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80619811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Food+and+Drug+Administration+pesticide+residue+monitoring+of+foods%3A+1983-1986.&rft.au=Yess%2C+N+J%3BHouston%2C+M+G%3BGunderson%2C+E+L&rft.aulast=Yess&rft.aufirst=N&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food and Drug Administration pesticide residue monitoring of foods: 1978-1982. AN - 80619742; 2050608 AB - Pesticide residues in foods are reported for the 5-year period 1978-1982 [fiscal years (FY) 78-82]. Results were compiled from the 2 complementary elements that comprise the Food and Drug Administration's (FDA) program for monitoring pesticide residues in foods. Under regulatory monitoring, which focuses on residues in raw agricultural commodities, a total of 49,877 samples (30,361 domestic and 19,516 import) that included fresh fruits and vegetables, grains, milk and dairy products, seafoods, and a variety of processed foods were analyzed. No residues were found in about 55 and 44% of the domestic and import samples, respectively. About 3% of the domestic and 7% of the import samples were classed as violative. Data from the Total Diet Study, which is conducted to determine dietary intakes of a variety of chemicals, showed that residues of 42 pesticides were found in 1044 composites of table-ready foods. Results of FDA's monitoring for FY78-82 demonstrate that pesticide residue levels in the U.S. food supply were generally well below regulatory limits, and dietary intakes were manyfold lower than the Acceptable Daily Intakes established by international agencies. JF - Journal - Association of Official Analytical Chemists AU - Yess, N J AU - Houston, M G AU - Gunderson, E L AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 265 EP - 272 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Data Collection -- methods KW - Diet KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80619742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Food+and+Drug+Administration+pesticide+residue+monitoring+of+foods%3A+1978-1982.&rft.au=Yess%2C+N+J%3BHouston%2C+M+G%3BGunderson%2C+E+L&rft.aulast=Yess&rft.aufirst=N&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunoassay of pesticides. AN - 80617092; 2050606 AB - Determination of the presence and levels of pesticide residues in food is fundamental in monitoring and regulatory programs. Residues are separated from the food matrix by solvent extraction, followed by cleanup steps. The residues are most often identified and quantitated by instrumental analysis, usually liquid or gas chromatography. Extraction and cleanup are often laborious and time-consuming; determination requires expensive, sophisticated instrumentation. There is a need for rapid, easily performed tests, such as immunoassays, that could be used for screening under field conditions or for quantitation of residues in foods in the laboratory. Although a large number of immunoassays have been developed for pesticide chemicals, very few have been specifically applied to foods, and only a very small number are currently available commercially. The agencies charged with monitoring and regulatory responsibilities--Environmental Protection Agency, Food and Drug Administration, and U.S. Department of Agriculture--as well as professional societies such as AOAC and the International Union of Pure and Applied Chemistry, are investigating and developing guidelines for test kit evaluation and standards to be met before a kit can be accepted as a practical and useful method of analysis for use in their programs. JF - Journal - Association of Official Analytical Chemists AU - Kaufman, B M AU - Clower, M AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 239 EP - 247 VL - 74 IS - 2 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - Immunoassay -- methods KW - Immunoenzyme Techniques KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80617092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Immunoassay+of+pesticides.&rft.au=Kaufman%2C+B+M%3BClower%2C+M&rft.aulast=Kaufman&rft.aufirst=B&rft.date=1991-03-01&rft.volume=74&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of dose-response relationships inferred by statistically significant trend tests. AN - 80613135; 2049495 AB - A method is proposed for classifying various experimental outcomes associated with statistically significant trend tests according to a set of sequential testing within a family of closed (under intersections) one-sided tests. The intent of the procedure is to characterize the general shape of implied dose-response relationships, taking care neither to inflate the false-positive (Type I) error rate by overtesting, nor to sacrifice power by overadjusting for multiple comparisons. JF - Biometrics AU - Kodell, R L AU - Chen, J J AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 139 EP - 146 VL - 47 IS - 1 SN - 0006-341X, 0006-341X KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Carcinogens -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity KW - Data Interpretation, Statistical KW - Biometry KW - Dose-Response Relationship, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80613135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Characterization+of+dose-response+relationships+inferred+by+statistically+significant+trend+tests.&rft.au=Kodell%2C+R+L%3BChen%2C+J+J&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-03-01&rft.volume=47&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Polymerase chain reaction identification of Vibrio vulnificus in artificially contaminated oysters. AN - 80580430; 2039231 AB - DNAs extracted from Vibrio vulnificus seeded into oyster homogenates were evaluated as templates for the polymerase chain reaction. Several extraction procedures were examined, and it was determined that DNA recovered from cells lysed by guanidine isothiocyanate, extracted with chloroform, and precipitated with ethanol was most suitable for use as a polymerase chain reaction template. The region targeted was a 519-bp portion of the cytotoxin-hemolysin gene of V. vulnificus. This region was amplified only when DNA from this species was present in the homogenate. V. vulnificus seeded into oyster homogenates at an initial level of 10(2) CFU/g of oyster meat was consistently observed after 24 h of incubation in alkaline peptone water. JF - Applied and environmental microbiology AU - Hill, W E AU - Keasler, S P AU - Trucksess, M W AU - Feng, P AU - Kaysner, C A AU - Lampel, K A AD - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 707 EP - 711 VL - 57 IS - 3 SN - 0099-2240, 0099-2240 KW - DNA, Bacterial KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Polymerase Chain Reaction KW - Animals KW - Base Sequence KW - DNA, Bacterial -- isolation & purification KW - DNA, Bacterial -- genetics KW - Molecular Sequence Data KW - Ostreidae -- microbiology KW - Vibrio -- genetics KW - Food Contamination KW - Vibrio -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80580430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Polymerase+chain+reaction+identification+of+Vibrio+vulnificus+in+artificially+contaminated+oysters.&rft.au=Hill%2C+W+E%3BKeasler%2C+S+P%3BTrucksess%2C+M+W%3BFeng%2C+P%3BKaysner%2C+C+A%3BLampel%2C+K+A&rft.aulast=Hill&rft.aufirst=W&rft.date=1991-03-01&rft.volume=57&rft.issue=3&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-02 N1 - Date created - 1991-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Nucleic Acids Res. 1976 Sep;3(9):2303-8 [987581] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Infect Immun. 1985 Apr;48(1):62-72 [3980095] Infect Immun. 1985 Dec;50(3):922-4 [4066036] Science. 1985 Dec 20;230(4732):1350-4 [2999980] Am J Med. 1986 Feb;80(2):336-8 [3946453] Appl Environ Microbiol. 1985 Dec;50(6):1548-9 [4091570] Appl Environ Microbiol. 1987 Jan;53(1):193-5 [3827248] Appl Environ Microbiol. 1987 Jun;53(6):1349-51 [3606112] Appl Environ Microbiol. 1987 Oct;53(10):2588-9 [3426222] Science. 1988 Jan 29;239(4839):487-91 [2448875] Mol Cell Probes. 1988 Mar;2(1):47-57 [3288864] Ann Intern Med. 1988 Aug 15;109(4):318-23 [3260760] J Clin Microbiol. 1989 Feb;27(2):261-5 [2644292] Mol Cell Probes. 1988 Sep;2(3):189-95 [3221883] Appl Environ Microbiol. 1990 Feb;56(2):307-14 [2306085] J Assoc Off Anal Chem. 1990 Mar-Apr;73(2):248-56 [2324035] Infect Immun. 1990 Aug;58(8):2706-9 [2370116] Appl Environ Microbiol. 1990 Jun;56(6):1536-40 [2200336] Lett Appl Microbiol. 1990 Jan;10(1):31-4 [1366574] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preventing adverse health effects from exposure to dimethylformamide (DMF). AN - 80562385; 2028916 JF - American Industrial Hygiene Association journal AU - NIOSH AD - NIOSH Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 2 EP - A160, A162 VL - 52 IS - 3 SN - 0002-8894, 0002-8894 KW - Solvents KW - 0 KW - Dimethylformamide KW - 8696NH0Y2X KW - Index Medicus KW - United States KW - Chemical and Drug Induced Liver Injury -- etiology KW - Maximum Allowable Concentration KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure KW - Dimethylformamide -- adverse effects KW - Liver -- enzymology KW - Liver -- drug effects KW - Solvents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80562385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Preventing+adverse+health+effects+from+exposure+to+dimethylformamide+%28DMF%29.&rft.au=NIOSH&rft.aulast=NIOSH&rft.aufirst=&rft.date=1991-03-01&rft.volume=52&rft.issue=3&rft.spage=A160&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-13 N1 - Date created - 1991-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The magnitude of the tissue residue problem with regard to consumer needs. AN - 80548087; 2026525 JF - Journal of the American Veterinary Medical Association AU - Guest, G B AU - Paige, J C AD - US Department of Health and Human Services, Food and Drug Administration, Center for Veterinary Medicine, Rockville, MD 20857. Y1 - 1991/03/01/ PY - 1991 DA - 1991 Mar 01 SP - 805 EP - 808 VL - 198 IS - 5 SN - 0003-1488, 0003-1488 KW - Anti-Bacterial Agents KW - 0 KW - Hormones KW - Sulfamethazine KW - 48U51W007F KW - Index Medicus KW - United States KW - Sulfamethazine -- analysis KW - Animals KW - Hormones -- analysis KW - Anti-Bacterial Agents -- analysis KW - Food Inspection KW - Meat -- standards KW - United States Food and Drug Administration KW - Consumer Product Safety KW - Drug Residues -- analysis KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80548087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Veterinary+Medical+Association&rft.atitle=The+magnitude+of+the+tissue+residue+problem+with+regard+to+consumer+needs.&rft.au=Guest%2C+G+B%3BPaige%2C+J+C&rft.aulast=Guest&rft.aufirst=G&rft.date=1991-03-01&rft.volume=198&rft.issue=5&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Veterinary+Medical+Association&rft.issn=00031488&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative regioselective and stereoselective metabolism of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene by mouse and rat liver microsomes. AN - 80492811; 2009583 AB - Quantitative metabolism of 7-chlorobenz[a]anthracene (7-Cl-BA) and 7-bromobenz[a]anthracene (7-Br-BA) by liver microsomes of uninduced mice and rats was studied. Both enzymatic systems metabolize 7-Cl-BA preferentially at the C-8 and C-9 aromatic double bond region, approximately 42 and approximately 56% respectively, of the total metabolites. 7-Cl-BA and 7-Br-BA were metabolized considerably at C-3 and C-4, C-5 and C-6, C-8 and C-9, and C-10 and C-11. While 7-Cl-BA trans-3,4-dihydrodiol was formed in a 7-8% yield of the total metabolites in both enzymatic systems, 7-Br-BA trans-3,4-dihydrodiol was formed 16.0 and 9.9% respectively, from the mouse and rat liver microsomal metabolism. In mutagenicity assays with the Salmonella typhimurium tester strain TA100 in the presence of S9 activation enzymes, both of these trans-3,4-dihydrodiols exhibited higher mutagenicity than 7-Cl-BA and 7-Br-BA, while the other trans-dihydrodiol metabolites were either essentially inactive or weaker than the parent compounds. These results suggest that 7-Cl-BA trans-3,4-dihydrodiol and 7-Br-BA trans-3,4-dihydrodiol are the proximate metabolites of 7-Cl-BA and 7-Br-BA. Metabolism of 7-Cl-BA and 7-Br-BA by mouse liver microsomes was also in a stereoselective manner, preferentially giving trans-dihydrodiol metabolites an R, R stereochemistry. JF - Carcinogenesis AU - Fu, P P AU - Von Tungeln, L S AU - Unruh, L E AU - Ni, Y C AU - Chou, M W AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 371 EP - 378 VL - 12 IS - 3 SN - 0143-3334, 0143-3334 KW - Anthracenes KW - 0 KW - Benz(a)Anthracenes KW - Mutagens KW - 7-chlorobenz(a)anthracene KW - 20268-52-4 KW - 7-bromobenzanthracene KW - 32795-84-9 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Stereoisomerism KW - Mutagenicity Tests -- methods KW - Mutagens -- metabolism KW - Chromatography, High Pressure Liquid -- methods KW - Salmonella typhimurium -- drug effects KW - Mice KW - Salmonella typhimurium -- genetics KW - Male KW - Anthracenes -- metabolism KW - Microsomes, Liver -- metabolism KW - Benz(a)Anthracenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80492811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Comparative+regioselective+and+stereoselective+metabolism+of+7-chlorobenz%5Ba%5Danthracene+and+7-bromobenz%5Ba%5Danthracene+by+mouse+and+rat+liver+microsomes.&rft.au=Fu%2C+P+P%3BVon+Tungeln%2C+L+S%3BUnruh%2C+L+E%3BNi%2C+Y+C%3BChou%2C+M+W&rft.aulast=Fu&rft.aufirst=P&rft.date=1991-03-01&rft.volume=12&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-07 N1 - Date created - 1991-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Silicosis and lung cancer in U.S. metal miners. AN - 80482126; 2006898 AB - The association between silicosis and lung cancer mortality was estimated in 9,912 (369 silicotics and 9,543 nonsilicotics) white male metal miners. These miners were examined by the U.S. Public Health Service during 1959-1961 and were followed through 1975. Miners were excluded from this study if they were employed in a mine during 1959-1961 that used diesel equipment underground. The ores that were mined consisted of copper, lead-zinc, iron, mercury, lead silver, gold and gold-silver, tungsten, and molybenum. The standardized mortality ratio (SMR, U.S. white male rates) for lung cancer was 1.73 (95% CI: .94-2.90) in silicotics and 1.18 (95% CI: .98-1.42) in nonsilicotics. Additionally, SMRs were higher in silicotics than in nonsilicotics, even in most subgroups stratified by cigarette smoking habit, type of ore mined, years of service in an underground job, radon exposure group, or year of hire. When lung cancer mortality between silicotics and nonsilicotics was compared, the age-adjusted rate ratio (95% CI) was 1.56 (.91-2.68), and the age- and smoking-adjusted rate ratio was 1.96 (.98-3.67). Corresponding figures for miners who were employed in mines with low levels of radon exposure were 1.90 (.98-3.67) and 2.59 (1.44-4.68), respectively. These findings indicate that lung cancer mortality risk was increased in silicotics, and this probably did not result from chance or bias. However, confounding from radon exposure could not be ruled out. The findings indicate that further follow-up of this cohort is needed. JF - Archives of environmental health AU - Amandus, H AU - Costello, J AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia. PY - 1991 SP - 82 EP - 89 VL - 46 IS - 2 SN - 0003-9896, 0003-9896 KW - Radon KW - Q74S4N8N1G KW - Abridged Index Medicus KW - Index Medicus KW - Causality KW - Occupational Exposure KW - United States Public Health Service KW - Humans KW - Radon -- adverse effects KW - Smoking -- epidemiology KW - Cause of Death KW - Comorbidity KW - Risk Factors KW - Cohort Studies KW - Confounding Factors (Epidemiology) KW - Radiography KW - Bias (Epidemiology) KW - United States -- epidemiology KW - Male KW - Silicosis -- diagnostic imaging KW - Occupational Diseases -- diagnostic imaging KW - Lung Neoplasms -- epidemiology KW - Silicosis -- mortality KW - Silicosis -- epidemiology KW - Occupational Diseases -- epidemiology KW - Lung Neoplasms -- mortality KW - Mining KW - Lung Neoplasms -- diagnostic imaging KW - Metallurgy KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80482126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Silicosis+and+lung+cancer+in+U.S.+metal+miners.&rft.au=Amandus%2C+H%3BCostello%2C+J&rft.aulast=Amandus&rft.aufirst=H&rft.date=1991-03-01&rft.volume=46&rft.issue=2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-19 N1 - Date created - 1991-04-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Tissue doses in the upper gastrointestinal fluoroscopy examination. AN - 80442540; 1994397 AB - A method was developed to estimate tissue doses from the upper gastrointestinal fluoroscopy examination. It involved measuring the technical parameters of the clinical examination, partitioning the dynamic examination into a set of discrete x-ray fields, and generating corresponding tissue does tables with an existing computer program. Knowledge of the radiation exposures associated with each of the fields enabled the calculation of tissue doses for the entire dynamic examination. In this limited sample (eight patients), fluoroscopy times ranged from 108 to 183 seconds. Radiation exposures ranged from 2.3 to 7.2 mC/kg (9.1-28 R), thyroid doses from 0.15 to 3.5 mGy (15-350 mrad), uterine doses from 0.16 to 1.0 mGy (16-100 mrad), lung doses from 0.90 to 4.2 mGy (90-420 mrad), and active bone marrow doses from 0.81 to 5.4 mGy (81-540 mrad). JF - Radiology AU - Suleiman, O H AU - Anderson, J AU - Jones, B AU - Rao, G U AU - Rosenstein, M AD - Office of Training and Assistance, Food and Drug Administration, Rockville, Md. 20857. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 653 EP - 658 VL - 178 IS - 3 SN - 0033-8419, 0033-8419 KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Exposure KW - Radiometry KW - Maximum Allowable Concentration KW - Humans KW - Environmental Exposure KW - Time Factors KW - Radiation Dosage KW - Radiation Protection KW - Digestive System -- diagnostic imaging KW - Fluoroscopy -- methods KW - Fluoroscopy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80442540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Tissue+doses+in+the+upper+gastrointestinal+fluoroscopy+examination.&rft.au=Suleiman%2C+O+H%3BAnderson%2C+J%3BJones%2C+B%3BRao%2C+G+U%3BRosenstein%2C+M&rft.aulast=Suleiman&rft.aufirst=O&rft.date=1991-03-01&rft.volume=178&rft.issue=3&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-21 N1 - Date created - 1991-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Radiology. 1991 Mar;178(3):622-3 [1994387] Erratum In: Radiology 1991 Jun;179(3):881 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 80436049; 1899454 JF - JAMA AU - Nightingale, S L AD - Office of Health Affairs, FDA, Rockville, MD 20857. Y1 - 1991/02/20/ PY - 1991 DA - 1991 Feb 20 SP - 847 VL - 265 IS - 7 SN - 0098-7484, 0098-7484 KW - Contraceptive Agents, Female KW - 0 KW - Cyanides KW - Drug Implants KW - Nitroprusside KW - 169D1260KM KW - Norgestrel KW - 3J8Q1747Z2 KW - Levonorgestrel KW - 5W7SIA7YZW KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Prosthesis Failure KW - United States Food and Drug Administration KW - Humans KW - Cyanides -- poisoning KW - Heart Valve Prosthesis KW - Nitroprusside -- adverse effects KW - Contraceptive Agents, Female -- administration & dosage KW - Drug Labeling KW - Norgestrel -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80436049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1991-02-20&rft.volume=265&rft.issue=7&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-13 N1 - Date created - 1991-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Correlation of pharmacokinetic data with endpoints of developmental toxicity. AN - 80632496; 2055352 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Young, J F AD - Division of Reproductive and Developmental Toxicology, Food and Drug Administration, DHHS, Jefferson, Arkansas 72079. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 222 EP - 224 VL - 16 IS - 2 SN - 0272-0590, 0272-0590 KW - Teratogens KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Data Interpretation, Statistical KW - Research Design KW - Teratogens -- pharmacokinetics KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80632496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Correlation+of+pharmacokinetic+data+with+endpoints+of+developmental+toxicity.&rft.au=Young%2C+J+F&rft.aulast=Young&rft.aufirst=J&rft.date=1991-02-01&rft.volume=16&rft.issue=2&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-26 N1 - Date created - 1991-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the onset and duration of response to cold air inhalation challenge in cynomolgus monkeys (Macaca fascicularis). AN - 80539273; 2022812 AB - Cold air inhalation challenge (CAIC) for the evaluation of bronchial reactivity has been proposed as a physical agent alternative to chemical agent challenges (methacholine or histamine), especially suitable for the occupational environment. The present investigation describes and evaluates a method for performing cold air inhalation challenge in Cynomolgus monkeys (Macaca fascicularis), a species shown to be useful in animal modeling studies of occupational asthma. Six adult male anesthetized monkeys were ventilated by changes in external pressure while breathing cold air (-25 degrees C to -30 degrees C). Pulmonary function testing was performed at 10, 25, 40 and 55 min post-challenge. Significant increases (P less than 0.05) in average pulmonary flow resistance (RL) and decreases in dynamic compliance (CL dyn) were observed, with maximum impairment occurring at 25 min post-challenge, with a trend towards a return to baseline values at 55 min post-challenge. Peak expiratory flow rate (PEFR), forced expiratory volume in 0.5 s/forced vital capacity (FEV0.5/FVC) and forced expiratory flow at 50% forced vital capacity (FEF50) showed the same general pattern of reduction as seen with RL; however, these results were not statistically significant, most probably owing to individual monkey variability and the small number of monkeys (N = 6) used. A repeat challenge at 25 min after a primary challenge yielded increased RL in one monkey, suggesting that no absolute refractory period is present from CAIC. Results of these studies demonstrate that CAIC causes bronchoconstriction in monkeys and may be useful in further animal modeling studies designed to determine the asthmogenic/airway irritant potential of occupational toxicants. JF - Journal of applied toxicology : JAT AU - Biagini, R E AU - Clark, J C AU - Moorman, W J AU - Knecht, E A AD - Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 1 EP - 6 VL - 11 IS - 1 SN - 0260-437X, 0260-437X KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Index Medicus KW - Methacholine Chloride -- pharmacology KW - Animals KW - Airway Resistance KW - Lung -- drug effects KW - Lung -- physiology KW - Male KW - Macaca fascicularis -- physiology KW - Bronchoconstriction KW - Cold Temperature KW - Air UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80539273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Evaluation+of+the+onset+and+duration+of+response+to+cold+air+inhalation+challenge+in+cynomolgus+monkeys+%28Macaca+fascicularis%29.&rft.au=Biagini%2C+R+E%3BClark%2C+J+C%3BMoorman%2C+W+J%3BKnecht%2C+E+A&rft.aulast=Biagini&rft.aufirst=R&rft.date=1991-02-01&rft.volume=11&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-05 N1 - Date created - 1991-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung cancer in mild steel welders. AN - 80466066; 2000839 AB - To investigate lung cancer risk, the authors conducted a historical cohort mortality study of 4,459 mild steel welders who had been employed at three midwestern plants which manufactured heavy equipment. Follow-up began in the mid-1950s and extended through 1988. All welders had at least 2 years welding experience (average duration, 8.5 years). This cohort had no occupational exposure to asbestos or stainless steel fumes (containing nickel and chromium), two potential confounders in previous welders studies. A comparison population of 4,286 nonwelders, all with at least 2 years employment at the same plants, was also studied. Nonwelders had never been welders and were allowed to have no more than 90 days employment as a painter, foundryman, or machinist. Sampling data collected from 1974-1987 indicated that welders were exposed to 6-7 mg/m3 of total particulate and 3-4 mg/m3 of iron oxide, while nonwelders had negligible exposures to welding fumes. When compared with the United States population, both welders and nonwelders had elevated rates for lung cancer (standardized mortality ratios (SMRs): welders, SMR = 1.07; nonwelders, SMR = 1.17), but neither SMR was significantly elevated. Limited smoking data based on a 1985 survey indicated that both welders and nonwelders smoked more than the United States population, possibly accounting for part of their elevated lung cancer rates. There was no trend of increased risk for welders with increased duration of exposure. The only other cause of death significantly elevated was emphysema among welders. Nonmalignant respiratory disease was not elevated for welders (SMR = 0.96). When welders were compared with nonwelders directly for lung cancer, the rate ratio was 0.90. JF - American journal of epidemiology AU - Steenland, K AU - Beaumont, J AU - Elliot, L AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991/02/01/ PY - 1991 DA - 1991 Feb 01 SP - 220 EP - 229 VL - 133 IS - 3 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Cohort Studies KW - United States -- epidemiology KW - Time Factors KW - Smoking -- epidemiology KW - Male KW - Cause of Death KW - Occupational Exposure KW - Lung Neoplasms -- epidemiology KW - Welding KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80466066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Lung+cancer+in+mild+steel+welders.&rft.au=Steenland%2C+K%3BBeaumont%2C+J%3BElliot%2C+L&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-02-01&rft.volume=133&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-08 N1 - Date created - 1991-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recommended protocols based on a survey of current practice in genotoxicity testing laboratories: III. Cell transformation in C3H/10T1/2 mouse embryo cell, BALB/c 3T3 mouse fibroblast and Syrian hamster embryo cell cultures. AN - 80450593; 1996125 AB - A standardized protocol and guidelines for the performance of cell transformation testing in mouse embryo (C3H/10T1/2), mouse fibroblast (BALB/c 3T3) and Syrian hamster embryo (SHE) cells have been developed. The protocol is based primarily on current laboratory practices as determined by responses to a detailed questionnaire completed by North American and European governmental, university and contract laboratories involved with cell transformation experimentation. This report identifies those modifications to previously described methodologies which are being used on a regular basis and also serves to clarify confusing or inconsistent practices. JF - Mutation research AU - Dunkel, V C AU - Rogers, C AU - Swierenga, S H AU - Brillinger, R L AU - Gilman, J P AU - Nestmann, E R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 285 EP - 300 VL - 246 IS - 2 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Cells, Cultured KW - Mice KW - Cricetinae KW - Mutagenicity Tests -- methods KW - Cell Transformation, Neoplastic -- drug effects KW - Mutagenicity Tests -- standards KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80450593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Recommended+protocols+based+on+a+survey+of+current+practice+in+genotoxicity+testing+laboratories%3A+III.+Cell+transformation+in+C3H%2F10T1%2F2+mouse+embryo+cell%2C+BALB%2Fc+3T3+mouse+fibroblast+and+Syrian+hamster+embryo+cell+cultures.&rft.au=Dunkel%2C+V+C%3BRogers%2C+C%3BSwierenga%2C+S+H%3BBrillinger%2C+R+L%3BGilman%2C+J+P%3BNestmann%2C+E+R&rft.aulast=Dunkel&rft.aufirst=V&rft.date=1991-02-01&rft.volume=246&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-22 N1 - Date created - 1991-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Mutat Res. 1991 Feb;246(2):227-33 [1996122] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. AN - 80437904; 1992763 AB - Acetaminophen overdose causes severe hepatotoxicity in humans and laboratory animals, presumably by metabolism to N-acetyl-p-benzoquinone imine: and binding to cysteine groups as 3-(cystein-S-yl)acetaminophen-protein adduct. Antiserum specific for the adduct was used immunohistochemically to demonstrate the formation, distribution, and concentration of this specific adduct in livers of treated mice and was correlated with cell injury as a function of dose and time. Within the liver lobule, immunohistochemically demonstrable adduct occurred in a temporally progressive, central-to-peripheral pattern. There was concordance between immunohistochemical staining and quantification of the adduct in hepatic 10,000g supernate, using a quantitative particle concentration fluorescence immunoassay. Findings include: 1) immunochemically detectable adduct before the appearance of centrilobular necrosis, 2) distinctive lobular zones of adduct localization with subsequent depletion during the progression of toxicity, 3) drug-protein binding in hepatocytes at subhepatotoxic doses and before depletion of total hepatic glutathione, 4) immunohistochemical evidence of drug binding in the nucleus, and 5) adduct in metabolically active and dividing hepatocytes and in macrophagelike cells in the regenerating liver. JF - The American journal of pathology AU - Roberts, D W AU - Bucci, T J AU - Benson, R W AU - Warbritton, A R AU - McRae, T A AU - Pumford, N R AU - Hinson, J A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 359 EP - 371 VL - 138 IS - 2 SN - 0002-9440, 0002-9440 KW - Acetaminophen KW - 362O9ITL9D KW - 3-(cystein-S-yl)paracetamol KW - 6Q2X58Y8BP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Mice KW - Tissue Distribution KW - Time Factors KW - Immunohistochemistry KW - Male KW - Liver -- pathology KW - Liver -- drug effects KW - Liver -- metabolism KW - Acetaminophen -- analogs & derivatives KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80437904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Immunohistochemical+localization+and+quantification+of+the+3-%28cystein-S-yl%29-acetaminophen+protein+adduct+in+acetaminophen+hepatotoxicity.&rft.au=Roberts%2C+D+W%3BBucci%2C+T+J%3BBenson%2C+R+W%3BWarbritton%2C+A+R%3BMcRae%2C+T+A%3BPumford%2C+N+R%3BHinson%2C+J+A&rft.aulast=Roberts&rft.aufirst=D&rft.date=1991-02-01&rft.volume=138&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-14 N1 - Date created - 1991-03-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1971 Mar 13;1(7698):519-22 [4100436] Biochem Pharmacol. 1990 Aug 1;40(3):573-9 [2200409] J Pharmacol Exp Ther. 1973 Oct;187(1):195-202 [4746327] Biochem Pharmacol. 1974 Oct 15;23(20):2785-94 [4429585] Br Med J. 1966 Aug 27;2(5512):497-9 [5913083] Br J Pharmacol Chemother. 1966 Mar;26(3):606-14 [5959211] Anal Biochem. 1969 Mar;27(3):502-22 [4388022] Anal Biochem. 1976 May 7;72:248-54 [942051] JAMA. 1976 Dec 13;236(24):2777-8 [1036573] Clin Chem. 1978 Jan;24(1):58-73 [22409] Biochem Pharmacol. 1981 Sep 15;30(18):2513-20 [7306203] Drug Metab Dispos. 1982 Jan-Feb;10(1):47-50 [6124382] J Med Chem. 1982 Jul;25(7):753-65 [7050382] J Med Chem. 1982 Aug;25(8):885-6 [7120276] Isr J Med Sci. 1984 Feb;20(2):145-7 [6706539] Proc Natl Acad Sci U S A. 1984 Mar;81(5):1327-31 [6424115] Mol Pharmacol. 1985 May;27(5):566-73 [3990678] Chem Biol Interact. 1985 Feb-Apr;53(1-2):155-72 [3995650] Blood. 1985 Aug;66(2):306-11 [4040409] Br Med J (Clin Res Ed). 1985 Oct 5;291(6500):938-9 [3929972] J Biol Chem. 1987 Jan 25;262(3):974-80 [3100532] J Pharmacol Exp Ther. 1987 May;241(2):527-33 [3572810] Biochem Pharmacol. 1987 Apr 15;36(8):1193-6 [3593409] Hepatology. 1987 Nov-Dec;7(6):1210-4 [2445642] Carcinogenesis. 1988 Jan;9(1):59-63 [3335048] Toxicol Pathol. 1987;15(4):431-8 [3432943] Annu Rev Pharmacol Toxicol. 1988;28:367-87 [3289490] Arch Biochem Biophys. 1988 Jul;264(1):253-60 [3395122] Biochem Pharmacol. 1988 Dec 15;37(24):4763-74 [3060126] J Pharmacol Exp Ther. 1989 Jan;248(1):182-9 [2464056] J Pharmacol Exp Ther. 1989 Jan;248(1):190-6 [2913271] J Pathol. 1988 Dec;156(4):275-82 [2465397] J Toxicol Environ Health. 1990;29(1):45-57 [2299686] Fundam Appl Toxicol. 1989 Nov;13(4):859-62 [2695380] Lancet. 1990 Mar 24;335(8691):732 [1969092] J Pharmacol Exp Ther. 1973 Oct;187(1):185-94 [4746326] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Circadian variation in alloxan sensitivity of mice as indicated by mortality and blood glucose alteration. AN - 72730741; 1814605 AB - The objective of this study was to determine in mice if a time-dependent pancreatic beta-cell susceptibility to alloxan could be correlated to daily changes in blood glucose levels and to monitor the pattern of blood glucose at various times of day as mice became diabetic. Food was removed from mice standardized to a 12-h light:dark cycle (lights on at 0600 h CST, during the month of June) at 12 h before subcutaneous injection with 0.27 mg/g of alloxan. Six groups of 30 fasted mice were injected at 4-h intervals. Blood glucose levels were measured from each group immediately prior to injection, and at 2, 4, 8, 12, 24, 48, and 216 h after treatment. Animals receiving alloxan during the early- to middark period had an increase in blood glucose after 2 h, followed by a decline to hypoglycemic levels between 4 and 8 h, and recovery to hyperglycemic levels 48 h after alloxan exposure. Three and 30% of these animals were dead at 8 and 48 h, respectively. Mice treated during the midlight span had decreased blood glucose levels 2 h after alloxan treatment followed by an increase to diabetic hyperglycemia within 48 h. Twenty-three and 70% of the animals treated at 1430 h were dead at 8 and 48 h, respectively. At 216 h, total mortality was 45.6% and 81 of the 98 surviving mice were hyperglycemic. These data suggest a greater sensitivity to alloxan during the midlight resting period of the mice. This may be the result of increased sensitivity to the insulin released from the beta cells when alloxan was given during the light span. JF - Chronobiology international AU - Feuers, R J AU - Mittelstaedt, R A AU - Hunter, J D AU - Saldivar, J AU - Tsai, T H AU - Scheving, L E AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 67 EP - 74 VL - 8 IS - 1 SN - 0742-0528, 0742-0528 KW - Blood Glucose KW - 0 KW - Alloxan KW - 6SW5YHA5NG KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Drug Administration Schedule KW - Death KW - Analysis of Variance KW - Mice KW - Male KW - Alloxan -- toxicity KW - Circadian Rhythm KW - Blood Glucose -- metabolism KW - Alloxan -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72730741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronobiology+international&rft.atitle=Circadian+variation+in+alloxan+sensitivity+of+mice+as+indicated+by+mortality+and+blood+glucose+alteration.&rft.au=Feuers%2C+R+J%3BMittelstaedt%2C+R+A%3BHunter%2C+J+D%3BSaldivar%2C+J%3BTsai%2C+T+H%3BScheving%2C+L+E&rft.aulast=Feuers&rft.aufirst=R&rft.date=1991-02-01&rft.volume=8&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Chronobiology+international&rft.issn=07420528&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-19 N1 - Date created - 1992-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. AN - 80359439; 1985242 AB - In both animal and epidemiologic studies, exposure to dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD) has been associated with an increased risk of cancer. We conducted a retrospective cohort study of mortality among the 5172 workers at 12 plants in the United States that produced chemicals contaminated with TCDD. Occupational exposure was documented by reviewing job descriptions and by measuring TCDD in serum from a sample of 253 workers. Causes of death were taken from death certificates. Mortality from several cancers previously associated with TCDD (stomach, liver, and nasal cancers, Hodgkin's disease, and non-Hodgkin's lymphoma) was not significantly elevated in this cohort. Mortality from soft-tissue sarcoma was increased, but not significantly (4 deaths; standardized mortality ratio [SMR], 338; 95 percent confidence interval, 92 to 865). In the subcohort of 1520 workers with greater than or equal to 1 year of exposure and greater than or equal to 20 years of latency, however, mortality was significantly increased for soft-tissue sarcoma (3 deaths; SMR, 922; 95 percent confidence interval, 190 to 2695) and for cancers of the respiratory system (SMR, 142; 95 percent confidence interval, 103 to 192). Mortality from all cancers combined was slightly but significantly elevated in the overall cohort (SMR, 115; 95 percent confidence interval, 102 to 130) and was higher in the subcohort with greater than or equal to 1 year of exposure and greater than or equal to 20 years of latency (SMR, 146; 95 percent confidence interval, 121 to 176). This study of mortality among workers with occupational exposure to TCDD does not confirm the high relative risks reported for many cancers in previous studies. Conclusions about an increase in the risk of soft-tissue sarcoma are limited by small numbers and misclassification on death certificates. Excess mortality from all cancers combined, cancers of the respiratory tract, and soft-tissue sarcoma may result from exposure to TCDD, although we cannot exclude the possible contribution of factors such as smoking and occupational exposure to other chemicals. JF - The New England journal of medicine AU - Fingerhut, M A AU - Halperin, W E AU - Marlow, D A AU - Piacitelli, L A AU - Honchar, P A AU - Sweeney, M H AU - Greife, A L AU - Dill, P A AU - Steenland, K AU - Suruda, A J AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Cincinnati, OH 45226. Y1 - 1991/01/24/ PY - 1991 DA - 1991 Jan 24 SP - 212 EP - 218 VL - 324 IS - 4 SN - 0028-4793, 0028-4793 KW - Polychlorinated Dibenzodioxins KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Tracheal Neoplasms -- mortality KW - Risk KW - Life Tables KW - Soft Tissue Neoplasms -- mortality KW - Sarcoma -- mortality KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Bronchial Neoplasms -- mortality KW - United States -- epidemiology KW - Male KW - Chemical Industry KW - Occupational Exposure KW - Neoplasms -- mortality KW - Polychlorinated Dibenzodioxins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80359439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Cancer+mortality+in+workers+exposed+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Fingerhut%2C+M+A%3BHalperin%2C+W+E%3BMarlow%2C+D+A%3BPiacitelli%2C+L+A%3BHonchar%2C+P+A%3BSweeney%2C+M+H%3BGreife%2C+A+L%3BDill%2C+P+A%3BSteenland%2C+K%3BSuruda%2C+A+J&rft.aulast=Fingerhut&rft.aufirst=M&rft.date=1991-01-24&rft.volume=324&rft.issue=4&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-07 N1 - Date created - 1991-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1991 Jun 20;324(25):1809-12 [2038371] N Engl J Med. 1991 Jan 24;324(4):260-2 [1823116] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium-dependent eicosanoid metabolism by concanavalin A-stimulated human monocytes in vitro. Synergism with phorbol ester indicates separate regulation of leukotriene B4 synthesis and release. AN - 80421982; 1846160 AB - Human monocytes obtained by counter-current centrifugal elutriation released arachidonic acid when challenged in vitro with Con A, as well as with other soluble (PMA or ionomycin) or particulate stimuli (serum-treated zymosan). Cyclo-oxygenase metabolites were the principal eicosanoids detected in the supernatants of Con A-stimulated, [3H]arachidonate-labeled monocytes, 5-Lipoxygenase (5-LO) products, such as leukotriene B4 (LTB4), were conspicuously absent. Release of arachidonate and its metabolites in response to Con A was dependent on the presence of extracellular Ca2+, but not Mg2+. In contrast to serum-treated zymosan challenge, which resulted in increased inositol trisphosphate and LTB4 release, Con A-induced inositol phospholipid hydrolysis in monocytes was limited to phosphatidylinositol or phosphatidylinositol monophosphate. Despite an inability to augment LTB4 release, Con A or PMA induced a loss of 5-lipoxygenase from a cytosolic compartment that was similar to that achieved with a calcium ionophore (ionomycin), a potent stimulus for LTB4 generation. When cell-associated LTB4 was evaluated, evidence for increased LTB4 production was obtained in response to either stimulus (PMA greater than Con A). In combination, however, PMA and Con A treatment resulted in monocyte LTB4 release comparable with that observed with the calcium ionophore or STZ. LTB4 release in response to all stimuli tested was inhibited by MK-886, a drug that binds to 5-lipoxygenase-activating protein. These results indicate the following: 1) Phospholipase A2 activation and attendant arachidonic acid release induced by agents that increase intracellular Ca2+ and/or generate diacylglycerol results in increased synthesis and release of PG and increased synthesis of leukotrienes, but not necessarily leukotriene release. 2) 5-LO translocation, which may occur independently of increased intracellular Ca2+, may be necessary for LTB4 generation but is insufficient for its release. 3) 5-Lipoxygenase-activating protein activity is necessary for 5-LO activation and LTB4 release in response to all stimuli investigated here. 4) Phorbol ester, an activator of protein kinase C, may synergize with agents such as Con A (which by themselves induce a minimal intracellular Ca2+ rise), so as to result in the release of LTB4. Thus, Con A may represent a class of surface receptor-aggregating agents that initiates inflammatory changes or immunomodulation associated with liberation of PG and might predispose to release of other inflammatory mediators, such as leukotrienes, in the presence of additional signals including protein kinase activation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Hoffman, T AU - Brando, C AU - Lizzio, E F AU - Lee, Y L AU - Hansen, M AU - Tripathi, A K AU - Taplits, M AU - Puri, J AU - Bonvini, E AU - Abrahamsen, T G AD - Division of Hematology, United States Food and Drug Administration, Bethesda, MD 20892. Y1 - 1991/01/15/ PY - 1991 DA - 1991 Jan 15 SP - 692 EP - 700 VL - 146 IS - 2 SN - 0022-1767, 0022-1767 KW - Arachidonic Acids KW - 0 KW - Eicosanoids KW - Indoles KW - Leukotriene Antagonists KW - Phosphatidylinositols KW - MK-886 KW - 080626SQ8C KW - Concanavalin A KW - 11028-71-0 KW - Leukotriene B4 KW - 1HGW4DR56D KW - Arachidonic Acid KW - 27YG812J1I KW - Arachidonate 5-Lipoxygenase KW - EC 1.13.11.34 KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Phosphatidylinositols -- metabolism KW - Enzyme Activation KW - Humans KW - Biological Transport KW - Arachidonic Acids -- metabolism KW - Arachidonate 5-Lipoxygenase -- metabolism KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Indoles -- pharmacology KW - Phospholipases A -- metabolism KW - Leukotriene B4 -- metabolism KW - Eicosanoids -- metabolism KW - Monocytes -- metabolism KW - Calcium -- physiology KW - Monocytes -- drug effects KW - Concanavalin A -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80421982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Calcium-dependent+eicosanoid+metabolism+by+concanavalin+A-stimulated+human+monocytes+in+vitro.+Synergism+with+phorbol+ester+indicates+separate+regulation+of+leukotriene+B4+synthesis+and+release.&rft.au=Hoffman%2C+T%3BBrando%2C+C%3BLizzio%2C+E+F%3BLee%2C+Y+L%3BHansen%2C+M%3BTripathi%2C+A+K%3BTaplits%2C+M%3BPuri%2C+J%3BBonvini%2C+E%3BAbrahamsen%2C+T+G&rft.aulast=Hoffman&rft.aufirst=T&rft.date=1991-01-15&rft.volume=146&rft.issue=2&rft.spage=692&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-19 N1 - Date created - 1991-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules AN - 19797245; 8740371 AB - We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis. Images JF - Nucleic Acids Research AU - Graessmann, M AU - Michaels, G AU - Berg, B AU - Graessmann, A AD - Department of Health and Human Services, National Institute of Health, Bethesda, MA 20892, USA Y1 - 1991/01/11/ PY - 1991 DA - 1991 Jan 11 SP - 53 EP - 59 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 19 IS - 1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gene expression KW - Antisense RNA KW - Simian virus 40 KW - DNA KW - Microinjection KW - W 30940:Products KW - V 22340:Antiviral Agents KW - N 14830:RNA KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19797245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Inhibition+of+SV40+gene+expression+by+microinjected+small+antisense+RNA+and+DNA+molecules&rft.au=Graessmann%2C+M%3BMichaels%2C+G%3BBerg%2C+B%3BGraessmann%2C+A&rft.aulast=Graessmann&rft.aufirst=M&rft.date=1991-01-11&rft.volume=19&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Antisense RNA; DNA; Microinjection; Simian virus 40 ER - TY - JOUR T1 - National objectives for reducing violent and abusive behavior AN - 839254069; 1079901 JF - Response to the victimization of women and children Y1 - 1991 PY - 1991 DA - 1991 SP - 21 VL - 14 IS - 1(78) SN - 0894-7597, 0894-7597 KW - Sociology KW - Domestic violence KW - Violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839254069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Response+to+the+victimization+of+women+and+children&rft.atitle=National+objectives+for+reducing+violent+and+abusive+behavior&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=14&rft.issue=1%2878%29&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Response+to+the+victimization+of+women+and+children&rft.issn=08947597&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13325; 3708 13325 ER - TY - JOUR T1 - Vacuuming a mercury-contaminated dental office may be hazardous to your health. AN - 80713883; 1860523 AB - Exposure to mercury contamination in the dental office poses a potential hazard for dental personnel. Although many precautions for containing the poisonous metal vapors are routinely observed, dental personnel may place themselves at risk by failing to use proper cleaning techniques. Researchers from the National Institute for Occupational Safety and Health (NIOSH) have discovered that vacuum cleaners designed for the home are sometimes used to clean dental office carpets, which might be contaminated with mercury. Since ordinary vacuum cleaners increase airborne mercury concentrations, dental personnel should use a specially designed vacuuming system for mercury recovery. JF - The Dental assistant AU - Votaw, A L AU - Zey, J AD - HETAB, NIOSH, R-9, Cincinnati, OH. PY - 1991 SP - 27 EP - 29 VL - 60 IS - 1 SN - 0011-8508, 0011-8508 KW - Mercury KW - FXS1BY2PGL KW - Dentistry KW - United States KW - Occupational Exposure KW - Dental Offices KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Mercury -- adverse effects KW - Housekeeping -- methods KW - Mercury -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80713883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Dental+assistant&rft.atitle=Vacuuming+a+mercury-contaminated+dental+office+may+be+hazardous+to+your+health.&rft.au=Votaw%2C+A+L%3BZey%2C+J&rft.aulast=Votaw&rft.aufirst=A&rft.date=1991-01-01&rft.volume=60&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=The+Dental+assistant&rft.issn=00118508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-04 N1 - Date created - 1991-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A study of the prevalence of acute respiratory disorders among workers in the textile industry. AN - 80699800; 1856010 AB - An epidemiological study of 774 workers in seven eastern France cotton textile factories was conducted to determine the prevalence of acute respiratory disorders. From nine non-textile companies, 464 workers, stratified as to sex, age and tobacco consumption participated in the study as a control population. A questionnaire designed to elicit the respiratory symptoms (in particular the Monday tightness characterizing byssinosis) was administered to the 1238 workers. Peak-expiratory-flow (PEF) measurement was made for each subject, exposed and non-exposed, before the start of the shift on the day of the worker's return to work and repeated at the end of the shift. The PEF's variations during the workshift were studied. Present Monday tightness was mentioned by 48 cotton exposed workers (6.2%) and by 9 non-exposed (1.9%) (P less than 0.001). A 10% decrease in PEF during the shift was present in 63 cotton exposed workers (8.1%) and in 10 non-exposed (2.1%) (P less than 0.001). For the exposed population, Monday tightness was analysed using multiple logistic regression, showing an absence of a link with smoking, an increased occurrence after 20 years of exposure (OR = 7.3) and a link with current job (more frequent among those with the dustiest jobs) (OR = 4.9). The multiple logistic analysis of a 10% decrease in PEF showed effects of smoking habits (OR = 1.86). It also showed a link with "highly polluted job" history (OR = 2.7), but especially with present job (OR = 3.4). The absence of a constant link between Monday tightness and drop of the PEF was found. JF - International archives of occupational and environmental health AU - Massin, N AU - Moulin, J J AU - Wild, P AU - Meyer-Bisch, C AU - Mur, J M AD - INRS (French National Institute for Occupational Safety and Health), Vandoeuvre Les Nancy, France. Y1 - 1991 PY - 1991 DA - 1991 SP - 555 EP - 560 VL - 62 IS - 8 SN - 0340-0131, 0340-0131 KW - Index Medicus KW - Peak Expiratory Flow Rate KW - Humans KW - Adult KW - Surveys and Questionnaires KW - France -- epidemiology KW - Aged KW - Middle Aged KW - Male KW - Gossypium KW - Female KW - Prevalence KW - Multivariate Analysis KW - Byssinosis -- epidemiology KW - Byssinosis -- physiopathology KW - Textile Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80699800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+archives+of+occupational+and+environmental+health&rft.atitle=A+study+of+the+prevalence+of+acute+respiratory+disorders+among+workers+in+the+textile+industry.&rft.au=Massin%2C+N%3BMoulin%2C+J+J%3BWild%2C+P%3BMeyer-Bisch%2C+C%3BMur%2C+J+M&rft.aulast=Massin&rft.aufirst=N&rft.date=1991-01-01&rft.volume=62&rft.issue=8&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=International+archives+of+occupational+and+environmental+health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-29 N1 - Date created - 1991-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Proto-oncogene activation in rodent and human tumors. AN - 80675293; 2068988 AB - The transformation of a normal cell into a tumorigenic cell involves both the activation and concerted expression of proto-oncogenes and inactivation of suppressor genes. The activation of ras proto-oncogenes represents one step in the multistep process of carcinogenesis for a variety of rodent and human tumors. This activation is probably an early event in tumorigenesis in many cases and may be the 'initiation' event in some cases. Thus, a chemical that induces rodent tumors by activation of ras proto-oncogenes can potentially invoke one step of the neoplastic process in humans exposed to the chemical. Moreover, dominant transforming oncogenes other than ras have been detected in human tumors as well as rodent tumors. The involvement of these putative proto-oncogenes in the development of neoplasia is unclear at present. JF - Advances in experimental medicine and biology AU - Anderson, M W AU - You, M AU - Reynolds, S H AD - Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709. Y1 - 1991 PY - 1991 DA - 1991 SP - 235 EP - 243 VL - 283 SN - 0065-2598, 0065-2598 KW - Index Medicus KW - Animals KW - Humans KW - Lung Neoplasms -- genetics KW - Mice KW - Gene Expression Regulation KW - Mutation KW - Proto-Oncogenes KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80675293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Proto-oncogene+activation+in+rodent+and+human+tumors.&rft.au=Anderson%2C+M+W%3BYou%2C+M%3BReynolds%2C+S+H&rft.aulast=Anderson&rft.aufirst=M&rft.date=1991-01-01&rft.volume=283&rft.issue=&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-14 N1 - Date created - 1991-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of stemphyltoxin III, a metabolite of Alternaria alternata. AN - 80579262; 2036005 AB - Some common decay organisms of vegetables and ripened fruits are Alternaria species. Even fruits and vegetables kept under refrigeration can be spoiled by Alternaria species because the mold grows at low temperatures. Alternaria alternata is commonly found in grain in areas with a high incidence of esophageal cancer. Three metabolites, altertoxins I, II, and III, have been isolated from A. alternata and have hydroxyperylenequinone structures. Although other perylenequinone metabolites such as stemphyperylenol and stemphyltoxins I, II, III, and IV, have been isolated from Stemphylium botryosum var. lactucum, a plant pathogen and mold, we isolated and identified stemphyltoxin III from A. alternata. This metabolite was tested for mutagenicity in the Ames Salmonella typhimurium plate incorporation assay with and without Aroclor 1254-induced rat S-9 metabolic activation. A positive response was noted with and without metabolic activation in S. typhimurium TA98 and TA1537, and there was a marginal response in strain TA100. JF - Applied and environmental microbiology AU - Davis, V M AU - Stack, M E AD - Division of Toxicological Studies, Food and Drug Administration, Washington, D.C 20204. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 180 EP - 182 VL - 57 IS - 1 SN - 0099-2240, 0099-2240 KW - Mutagens KW - 0 KW - stemphyltoxin III KW - 102694-32-6 KW - Perylene KW - 5QD5427UN7 KW - Index Medicus KW - Mutagenicity Tests KW - Food Microbiology KW - Food Contamination KW - Perylene -- pharmacology KW - Perylene -- analogs & derivatives KW - Alternaria -- metabolism KW - Perylene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80579262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Mutagenicity+of+stemphyltoxin+III%2C+a+metabolite+of+Alternaria+alternata.&rft.au=Davis%2C+V+M%3BStack%2C+M+E&rft.aulast=Davis&rft.aufirst=V&rft.date=1991-01-01&rft.volume=57&rft.issue=1&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-24 N1 - Date created - 1991-06-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Experientia. 1984 Nov 15;40(11):1248-50 [6548712] Appl Environ Microbiol. 1986 Oct;52(4):718-22 [3535674] Mutat Res. 1975 Dec;31(6):347-64 [768755] J Nat Prod. 1989 Mar-Apr;52(2):426-7 [2746264] Carcinogenesis. 1987 Jul;8(7):989-91 [3594731] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of elemental mercury exposure at a thermometer plant. AN - 80573713; 2035548 AB - This study compares 84 mercury-exposed workers at a thermometer manufacturing facility with 79 unexposed workers for evidence of chronic mercury toxicity. Personal breathing-zone air concentrations of mercury ranged from 25.6 to 270.6 micrograms/m3 for thermometer workers. Urinary mercury levels in the study population ranged from 1.3 to 344.5 micrograms/g creatinine, with eight (10%) participants exceeding 150 micrograms/g creatinine and three workers exceeding 300 micrograms/g creatinine, which indicates increased absorption of mercury among the thermometer workers. All urine mercury levels in the comparison group were compatible with normal background levels in unexposed adults (less than 10 micrograms/g creatinine). Thermometer plant workers reported more symptoms than did controls; in general, these differences were not statistically significant and could not be specifically associated with mercury exposure. Static tremor, abnormal Romberg test, dysdiadochokinesia, and difficulty with heel-to-toe gait were more prevalent among thermometer workers than control workers, which could not be associated with recent mercury exposure; there was some suggestion of an association with chronic exposure. There were no intergroup differences for the standard clinical tests of renal function except for a significantly higher mean specific gravity among the thermometer workers. A positive correlation was found, however, between urinary N-acetyl-b-D-glucosaminidase (NAG) and urinary mercury. There was no consistent evidence for intergroup differences in proximal renal tubule function, as measured by urinary beta 2-microglobulin (B2M) or retinol binding protein (RBP). JF - American journal of industrial medicine AU - Ehrenberg, R L AU - Vogt, R L AU - Smith, A B AU - Brondum, J AU - Brightwell, W S AU - Hudson, P J AU - McManus, K P AU - Hannon, W H AU - Phipps, F C AD - National Institute for Occupational Safety and Health, CDC, Atlanta, GA 30333. Y1 - 1991 PY - 1991 DA - 1991 SP - 495 EP - 507 VL - 19 IS - 4 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Biomarkers KW - Retinol-Binding Proteins KW - beta 2-Microglobulin KW - Creatinine KW - AYI8EX34EU KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Retinol-Binding Proteins -- urine KW - Creatinine -- urine KW - Mercury -- urine KW - Humans KW - Biomarkers -- urine KW - beta 2-Microglobulin -- urine KW - Albuminuria -- chemically induced KW - Nervous System Diseases -- chemically induced KW - Occupational Diseases -- chemically induced KW - Environmental Monitoring KW - Nervous System Diseases -- epidemiology KW - Adult KW - Occupational Diseases -- epidemiology KW - Epidemiological Monitoring KW - Middle Aged KW - Female KW - Male KW - Proteinuria -- chemically induced KW - Prevalence KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Mercury Poisoning -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80573713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Effects+of+elemental+mercury+exposure+at+a+thermometer+plant.&rft.au=Ehrenberg%2C+R+L%3BVogt%2C+R+L%3BSmith%2C+A+B%3BBrondum%2C+J%3BBrightwell%2C+W+S%3BHudson%2C+P+J%3BMcManus%2C+K+P%3BHannon%2C+W+H%3BPhipps%2C+F+C&rft.aulast=Ehrenberg&rft.aufirst=R&rft.date=1991-01-01&rft.volume=19&rft.issue=4&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-21 N1 - Date created - 1991-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Does good peer review assure good epidemiology? AN - 80554910; 2030384 AB - The American public requires that research projects use resources efficiently, that they provide answers that are beneficial, and that they are carried out ethically. Peer review of research protocols, results, and reports, provides one way to improve research and to reassure the public. JF - Journal of clinical epidemiology AU - Andrews, J S AD - Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, Georgia. Y1 - 1991 PY - 1991 DA - 1991 SP - 131S EP - 134S VL - 44 Suppl 1 SN - 0895-4356, 0895-4356 KW - Bioethics KW - Index Medicus KW - Biomedical and Behavioral Research KW - Bioethics and Professional Ethics KW - Ethics, Medical KW - Research KW - Epidemiology -- standards KW - Peer Review -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80554910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Does+good+peer+review+assure+good+epidemiology%3F&rft.au=Andrews%2C+J+S&rft.aulast=Andrews&rft.aufirst=J&rft.date=1991-01-01&rft.volume=44+Suppl+1&rft.issue=&rft.spage=131S&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-20 N1 - Date created - 1991-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunoaffinity column coupled with solution fluorometry or liquid chromatography postcolumn derivatization for determination of aflatoxins in corn, peanuts, and peanut butter: collaborative study. AN - 80550777; 2026580 AB - An AOAC/IUPAC (International Union of Pure and Applied Chemistry) collaborative study was conducted to evaluate the effectiveness of an immunoaffinity column for the determination of aflatoxin. The test portion is extracted with methanol-water (7 + 3), filtered, diluted to less than 30% methanol with water, and applied to the affinity column. The column is washed with water and the concentrated aflatoxins are eluted with methanol. Total aflatoxins are determined by solution fluorometry with bromine (SFB), and individual toxins are determined by reverse-phase liquid chromatography with postcolumn derivatization with iodine (PCD). Corn naturally contaminated with aflatoxins, and peanuts, peanut butter, and corn containing added aflatoxins (B1:B2:G1:G2 = 7:1:3:1) were sent to 24 collaborators in the United States, France, Canada, and the Republic of South Africa. Twelve collaborators used the SFB method, 9 used the PCD method, and 3 used both SFB and PCD methods. Twenty collaborators completed the study (10 used the SFB method, 7 used the PCD method, and 3 used both SFB and PCD methods). Test portions were spiked at 10, 20, and 30 ng/g. For SFB analyses, recoveries of total aflatoxins were 123, 105, and 107%, respectively; the relative standard deviation for repeatability (RSDr) ranged from 11.75 to 16.57%, and the relative standard deviation for reproducibility (RSDR) ranged from 10.97 to 33.09%. For PCD analyses, recoveries were 81, 81, and 83%, respectively; the RSDr ranged from 5.20 to 17.22%, and the RSDR ranged from 4.68 to 50.77%. The RSDr for aflatoxins B1 and G1 for spiked test portions ranged from 5.45 to 23.55%, and the RSDR ranged from 4.21 to 57.28%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal - Association of Official Analytical Chemists AU - Trucksess, M W AU - Stack, M E AU - Nesheim, S AU - Page, S W AU - Albert, R H AU - Hansen, T J AU - Donahue, K F AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1991 SP - 81 EP - 88 VL - 74 IS - 1 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Index Medicus KW - Chromatography, Affinity KW - Spectrometry, Fluorescence KW - Chromatography, Liquid KW - Aflatoxins -- analysis KW - Arachis -- analysis KW - Zea mays -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80550777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Immunoaffinity+column+coupled+with+solution+fluorometry+or+liquid+chromatography+postcolumn+derivatization+for+determination+of+aflatoxins+in+corn%2C+peanuts%2C+and+peanut+butter%3A+collaborative+study.&rft.au=Trucksess%2C+M+W%3BStack%2C+M+E%3BNesheim%2C+S%3BPage%2C+S+W%3BAlbert%2C+R+H%3BHansen%2C+T+J%3BDonahue%2C+K+F&rft.aulast=Trucksess&rft.aufirst=M&rft.date=1991-01-01&rft.volume=74&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Scientific and regulatory considerations in the development of human growth factors. AN - 80550649; 1367138 JF - Bioprocess technology AU - Fleming, G A AU - Jordan, A W AU - Chiu, Y Y AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1991 PY - 1991 DA - 1991 SP - 341 EP - 354 VL - 13 SN - 0888-7470, 0888-7470 KW - Growth Hormone KW - 9002-72-6 KW - Biotechnology KW - Animals KW - Humans KW - Growth Hormone -- standards KW - Legislation, Drug KW - Growth Hormone -- pharmacology KW - Growth Hormone -- chemistry KW - Growth Hormone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80550649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioprocess+technology&rft.atitle=Scientific+and+regulatory+considerations+in+the+development+of+human+growth+factors.&rft.au=Fleming%2C+G+A%3BJordan%2C+A+W%3BChiu%2C+Y+Y&rft.aulast=Fleming&rft.aufirst=G&rft.date=1991-01-01&rft.volume=13&rft.issue=&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Bioprocess+technology&rft.issn=08887470&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-19 N1 - Date created - 1991-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. AN - 80536772; 2022192 AB - We have developed a limiting dilution clonal assay for determining the frequency of 6-thioguanine-resistant (TGr) lymphocytes produced in rats by in vivo exposure to genotoxic agents. Spleen lymphocytes were isolated from female Fischer 344 rats and were cultured with 1 microgram/ml of phytohemagglutinin (PHA) for 40 hr. Northern blot analysis revealed that this procedure resulted in increased hprt and beta-actin mRNA synthesis. Conditions for optimum cloning were established by culturing four PHA-primed lymphocytes/well in 96-well round-bottom microtiter plates containing a medium supplemented with interleukin-2. These cultures also contained autologous and/or TK6 feeder cells inactivated with different doses of irradiation. Lymphocyte cloning efficiencies (CEs) were highest in plates containing both irradiated TK6 cells (5 x 10(3) cells/well; 90 Gy) and irradiated autologous feeder cells (5 x 10(4) cells/well; 50 Gy). CE did not depend on the number of primed lymphocytes/well when four or fewer target cells/well were cloned. To measure the effects of chemical mutagens on the frequency of TGr lymphocytes, rats were given a single i.p. injection of 0-150 mg/kg of N-ethyl-N-nitrosourea (ENU), a direct-acting alkylating agent, or 0-50 mg/kg of cyclophosphamide (CP), an indirect acting alkylating agent. Lymphocytes were isolated, primed, and cloned at 4 weeks after CP treatment and at 1, 2, 4 and 6 weeks after ENU treatment. CE in these cultures ranged from 12% to 27%. Cultures were also established for measuring CE in the presence of 6-thioguanine (TG) and these contained 5 x 10(3) irradiated TK6 cells and 5 x 10(4) primed rat lymphocytes/well. The frequency of TGr lymphocytes was calculated by correcting the CE in the presence of TG with the CE measured in its absence. ENU exposure produced a higher frequency of TGr lymphocytes than CP, but both chemicals produced a dose-dependent increase in TGr cells. In addition, the frequency of ENU-induced TGr lymphocytes increased with time after treatment. The TGr cells are presumed to be hprt mutants, but further analysis at the DNA level is required to establish this. The dose-dependent responses obtained with both ENU and CP treatments suggest that rat lymphocytes are sensitive to direct- and indirect-acting alkylating agents administered in vivo and that the rat lymphocyte assay is a useful complement to the in vivo/in vitro mouse assay for determining the mutagenicity of environmental toxicants. JF - Environmental and molecular mutagenesis AU - Aidoo, A AU - Lyn-Cook, L E AU - Mittelstaedt, R A AU - Heflich, R H AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, Arkansas. Y1 - 1991 PY - 1991 DA - 1991 SP - 141 EP - 151 VL - 17 IS - 3 SN - 0893-6692, 0893-6692 KW - Actins KW - 0 KW - RNA, Messenger KW - Cyclophosphamide KW - 8N3DW7272P KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Thioguanine KW - FTK8U1GZNX KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Rats KW - Clone Cells KW - Animals KW - Rats, Inbred F344 KW - Blotting, Northern KW - Actins -- genetics KW - RNA, Messenger -- metabolism KW - Hypoxanthine Phosphoribosyltransferase -- metabolism KW - Drug Resistance KW - Female KW - Ethylnitrosourea -- toxicity KW - Mutagenicity Tests -- methods KW - Lymphocytes -- metabolism KW - Cyclophosphamide -- toxicity KW - Lymphocytes -- drug effects KW - Thioguanine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80536772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Induction+of+6-thioguanine-resistant+lymphocytes+in+Fischer+344+rats+following+in+vivo+exposure+to+N-ethyl-N-nitrosourea+and+cyclophosphamide.&rft.au=Aidoo%2C+A%3BLyn-Cook%2C+L+E%3BMittelstaedt%2C+R+A%3BHeflich%2C+R+H%3BCasciano%2C+D+A&rft.aulast=Aidoo&rft.aufirst=A&rft.date=1991-01-01&rft.volume=17&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-31 N1 - Date created - 1991-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nitro group orientation, reduction potential, and direct-acting mutagenicity of nitro-polycyclic aromatic hydrocarbons. AN - 80533929; 2022194 AB - Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are widespread genotoxic environmental pollutants. We have been interested in determining the structural and electronic features that may be useful in predicting the direct-acting mutagenic activity of nitro-PAHs in Salmonella typhimurium. In this study, a series of structurally related nitro-PAHs were used to determine the relationships among direct-acting mutagenicity, orientation of the nitro group, and reduction potential of the nitro group. The compounds consisted of isomeric mononitrated and dinitrated benzo[e]pyrenes, their derivatives, and other nitro-PAHs ranging from two to five aromatic-ring molecules in size. A general finding is that nitro-PAHs with their nitro substituent oriented perpendicular to the aromatic system exhibit either very weak or no direct-acting mutagenicity in S. typhimurium strains TA98 and TA100. However, if a nitro-PAH of this type has a relatively low first half-wave reduction potential, it may be direct-acting. Furthermore, a positive correlation between the first half-wave reduction potential and direct-acting mutagenicity is found only when the compounds are structurally similar. Consequently, the correlation cannot be made using nitro-PAHs with different molecular size. Nitro-PAHs having a perpendicular nitro orientation always have a higher (absolute value) first half-wave reduction potential than the isomer(s) with a parallel orientation. Perhaps due to electron-withdrawing by the second nitro group, dinitro-PAHs always have a lower first half-wave reduction potential than their mononitro analogues. These findings provide a useful molecular basis for interpreting and predicting the direct-acting mutagenicity of nitro-PAHs. JF - Environmental and molecular mutagenesis AU - Jung, H AU - Shaikh, A U AU - Heflich, R H AU - Fu, P P AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 169 EP - 180 VL - 17 IS - 3 SN - 0893-6692, 0893-6692 KW - Mutagens KW - 0 KW - Nitro Compounds KW - Polycyclic Compounds KW - 6-nitrosobenzo(a)pyrene KW - 118745-15-6 KW - 3-nitroso-7,8,9,10-tetrahydrobenzo(a)pyrene KW - 134998-76-8 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Oxidation-Reduction KW - Mutagenicity Tests KW - Polarography KW - Benzo(a)pyrene -- toxicity KW - Salmonella typhimurium -- drug effects KW - Electrochemistry KW - Structure-Activity Relationship KW - Nitro Compounds -- toxicity KW - Nitro Compounds -- chemistry KW - Polycyclic Compounds -- toxicity KW - Mutagens -- chemistry KW - Polycyclic Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80533929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Nitro+group+orientation%2C+reduction+potential%2C+and+direct-acting+mutagenicity+of+nitro-polycyclic+aromatic+hydrocarbons.&rft.au=Jung%2C+H%3BShaikh%2C+A+U%3BHeflich%2C+R+H%3BFu%2C+P+P&rft.aulast=Jung&rft.aufirst=H&rft.date=1991-01-01&rft.volume=17&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-31 N1 - Date created - 1991-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 4,4'-Methylenebis(2-chloroaniline) (MOCA): the effect of multiple oral administration, route, and phenobarbital induction on macromolecular adduct formation in the rat. AN - 80532780; 2019352 AB - The effect of multiple oral administration of MOCA, a suspect human carcinogen, was studied in the adult male rat. As many as 28 consecutive daily doses of [14C]MOCA at 28.1 mumol/kg body wt (5 microCi/day) were administered and rats were euthanized at weekly intervals for 7 weeks. MOCA adduct formation for globin and serum albumin was evaluated by determination of [14C]MOCA covalent binding. The covalent binding associated with globin showed a linear increase over the 28-day exposure period with 342 fmol/mg globin 24 hr after the final dose. More extensive covalent binding was detected for albumin with 443 fmol/mg albumin after the final dose, but increases were not linear. After cessation of dosing, the albumin adduct levels decreased rapidly (t1/2 = 4.6 days) in relation to globin adduct levels (t1/2 = 16.1 days). The MOCA-globin adduct t1/2 is consistent with that determined after a single 281 mumol/kg oral dose of MOCA. Significant differences related to route of administration were detected for 24-hr globin covalent binding with ip greater than po greater than dermal. Distribution of undifferentiated [14C]MOCA was highest in the liver at 24 hr with tissue levels for liver greater than kidney greater than lung greater than spleen greater than testes greater than urinary bladder. Induction of cytochrome P450 enzymes by administration of phenobarbital (100 mg/kg/day/3 days) resulted in a significant (p less than 0.05) increase in MOCA-globin adduct formation detected with 33.5 pmol/mg globin for induced rats versus 13.6 pmol/mg globin for control rats. Although MOCA-globin and albumin adducts show differing stability, quantification of such MOCA adducts may be useful for long-term industrial biomonitoring of MOCA. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Cheever, K L AU - DeBord, D G AU - Swearengin, T F AD - Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 71 EP - 80 VL - 16 IS - 1 SN - 0272-0590, 0272-0590 KW - Serum Albumin KW - 0 KW - Methylenebis(chloroaniline) KW - 3L2W5VTT2A KW - Globins KW - 9004-22-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Administration, Oral KW - Serum Albumin -- metabolism KW - Animals KW - Globins -- isolation & purification KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Tissue Distribution KW - Chromatography, High Pressure Liquid KW - Rats KW - Rats, Inbred Strains KW - Risk KW - Half-Life KW - Chromatography, Thin Layer KW - Globins -- metabolism KW - Male KW - Phenobarbital -- pharmacology KW - Enzyme Induction -- drug effects KW - Methylenebis(chloroaniline) -- toxicity KW - Methylenebis(chloroaniline) -- pharmacokinetics KW - Methylenebis(chloroaniline) -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80532780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=4%2C4%27-Methylenebis%282-chloroaniline%29+%28MOCA%29%3A+the+effect+of+multiple+oral+administration%2C+route%2C+and+phenobarbital+induction+on+macromolecular+adduct+formation+in+the+rat.&rft.au=Cheever%2C+K+L%3BDeBord%2C+D+G%3BSwearengin%2C+T+F&rft.aulast=Cheever&rft.aufirst=K&rft.date=1991-01-01&rft.volume=16&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet. AN - 80529821; 2019351 AB - Diet is a major influence on the responses of experimental animals to drugs, toxins, and carcinogens. Two diets used widely in toxicological and carcinogenic studies, and considered to be nutritionally adequate, were compared with respect to neoplastic responses to 2-acetylaminofluorene (2-AAF). Both sexes of weanling B6C3F1 mice were fed either AIN-76A (a purified diet) or NIH-07 (a natural ingredient diet), with or without 2-AAF, for up to 2 years. Dosages of 2-AAF were administered to males at 0, 40, 60, or 80 ppm in each diet and to females at 0, 150, 200, or 250 ppm. Each group consisted of 96 mice, except the groups of females dosed at 0 and 150 ppm, which consisted of 120 and 72 mice, respectively. The incidence of malignant liver tumors was significantly greater in all AIN-fed groups compared to corresponding NIH-fed groups, as was the total incidence of tumors (malignant + benign). Similarly, the incidence of malignant and total bladder tumors was greater in AIN-fed groups of mice administered the two high doses of 2-AAF for each sex compared to NIH-fed groups. No malignant bladder tumors were observed among any of the groups of mice receiving control diets. This was also true for the males on low dosages (40 ppm) of 2-AAF. The AIN-fed group of low dose females (150 ppm) developed 4% incidence of malignant bladder tumors. This study dramatically showed the importance of diet selection in chronic carcinogenic studies and suggests that results obtained with the use of a purified diet may differ both qualitatively and quantitatively from results obtained with a natural ingredient diet. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Fullerton, F R AU - Greenman, D L AU - McCarty, C C AU - Bucci, T J AD - National Center for Toxicological Research, Jefferson, Arkansas 72029. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 51 EP - 60 VL - 16 IS - 1 SN - 0272-0590, 0272-0590 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Body Weight -- drug effects KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Energy Intake KW - Mice KW - Male KW - Growth -- drug effects KW - Female KW - Urinary Bladder Neoplasms -- physiopathology KW - 2-Acetylaminofluorene -- toxicity KW - Liver Neoplasms, Experimental -- physiopathology KW - Liver Neoplasms, Experimental -- chemically induced KW - Diet KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80529821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Increased+incidence+of+spontaneous+and+2-acetylaminofluorene-induced+liver+and+bladder+tumors+in+B6C3F1+mice+fed+AIN-76A+diet+versus+NIH-07+diet.&rft.au=Fullerton%2C+F+R%3BGreenman%2C+D+L%3BMcCarty%2C+C+C%3BBucci%2C+T+J&rft.aulast=Fullerton&rft.aufirst=F&rft.date=1991-01-01&rft.volume=16&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of foodborne pathogens by nucleic acid hybridization. AN - 80524432; 2018707 AB - Nucleic acid hybridization methods have been developed and used to identify microorganisms in foods. Tests performed on mixed cultures save the time required to establish pure cultures. Enterotoxigenic or invasive strains of foodborne bacterial pathogens are detected with probes that identify genes responsible for virulence. Hybridization tests signal the presence or absence of a particular strain or an entire genus and are especially well suited for screening foods for specific pathogens. With the colony hybridization assay format, foodborne bacteria harboring a specific gene can be enumerated. However, hybridization tests require the presence of 10(5) to 10(6) cells to yield a positive result, thereby limiting sensitivity and necessitating a time-consuming growth step. In vitro DNA amplification techniques increase the amount of DNA segments 10(5)-10(6)-fold in 2 to 3 h, thus enhancing test sensitivity. JF - International journal of food microbiology AU - Hill, W E AU - Keasler, S P AD - Molecular Biology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 67 EP - 75 VL - 12 IS - 1 SN - 0168-1605, 0168-1605 KW - DNA Probes KW - 0 KW - RNA Probes KW - Index Medicus KW - Polymerase Chain Reaction KW - Bacterial Infections -- prevention & control KW - Virulence -- genetics KW - Nucleic Acid Hybridization KW - Bacterial Typing Techniques KW - Bacteria -- genetics KW - Food Microbiology KW - Viruses -- isolation & purification KW - Bacteria -- pathogenicity KW - Bacteria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80524432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Identification+of+foodborne+pathogens+by+nucleic+acid+hybridization.&rft.au=Hill%2C+W+E%3BKeasler%2C+S+P&rft.aulast=Hill&rft.aufirst=W&rft.date=1991-01-01&rft.volume=12&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Consequences of the nuclear power plant accident at Chernobyl. AN - 80454530; 1899937 AB - The Chernobyl Nuclear Power Plant accident, in the Ukrainian Soviet Socialist Republic (SSR), on April 26, 1986, was the first major nuclear power plant accident that resulted in a large-scale fire and subsequent explosions, immediate and delayed deaths of plant operators and emergency service workers, and the radioactive contamination of a significant land area. The release of radioactive material, over a 10-day period, resulted in millions of Soviets, and other Europeans, being exposed to measurable levels of radioactive fallout. Because of the effects of wind and rain, the radioactive nuclide fallout distribution patterns are not well defined, though they appear to be focused in three contiguous Soviet Republics: the Ukrainian SSR, the Byelorussian SSR, and the Russian Soviet Federated Socialist Republic. Further, because of the many radioactive nuclides (krypton, xenon, cesium, iodine, strontium, plutonium) released by the prolonged fires at Chernobyl, the long-term medical, psychological, social, and economic effects will require careful and prolonged study. Specifically, studies on the medical (leukemia, cancers, thyroid disease) and psychological (reactive depressions, post-traumatic stress disorders, family disorganization) consequences of continued low dose radiation exposure in the affected villages and towns need to be conducted so that a coherent, comprehensive, community-oriented plan may evolve that will not cause those already affected any additional harm and confusion. JF - Public health reports (Washington, D.C. : 1974) AU - Ginzburg, H M AU - Reis, E AD - Office of Emergency Preparedness, Health Resources and Services Administration, Public Health Service, Rockville, MD 20857. PY - 1991 SP - 32 EP - 40 VL - 106 IS - 1 SN - 0033-3549, 0033-3549 KW - Radioactive Fallout KW - 0 KW - Radioactive Pollutants KW - Abridged Index Medicus KW - Index Medicus KW - Ukraine -- epidemiology KW - Health Services Needs and Demand KW - Animals KW - Neoplasms, Radiation-Induced -- etiology KW - Humans KW - Radioactive Pollutants -- analysis KW - Food Contamination, Radioactive KW - Neoplasms, Radiation-Induced -- mortality KW - Morbidity KW - USSR KW - Radioactive Fallout -- adverse effects KW - Accidents -- mortality KW - Nuclear Reactors KW - Accidents -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80454530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Consequences+of+the+nuclear+power+plant+accident+at+Chernobyl.&rft.au=Ginzburg%2C+H+M%3BReis%2C+E&rft.aulast=Ginzburg&rft.aufirst=H&rft.date=1991-01-01&rft.volume=106&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-22 N1 - Date created - 1991-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1987 Oct 30;238(4827):622-3 [3672115] Am J Orthopsychiatry. 1990 Jan;60(1):35-42 [2407129] Public Health Rep. 1979 Nov-Dec;94(6):495-502 [515335] Am J Psychiatry. 1976 Mar;133(3):295-9 [1259039] Erratum In: Public Health Rep 1991 May-Jun;106(3):352 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Job dimensions associated with severe disability due to cardiovascular disease. AN - 80451933; 1825324 AB - This study explored associations among job activities and disability due to cardiovascular disease by merging national disability data with independently-obtained job activity data. Disability data were taken from a 1978 U.S. health interview survey (n = 9855). Expert ratings of job activities (dimensions) were obtained from a job analysis database (n = 2485 occupations). The two databases were merged such that job dimension data were imputed to each occupation in the disability database. Odds ratios for cardiovascular disability were calculated for scores in the second, third, and fourth quartiles for each of the 32 job dimensions, using scores in the first quartile as the standard. Job dimensions associated with cardiovascular disability were (a) hazardous situations; (b) vigilant work and responsibility for others; (c) exchanging job-related information; and (d) attention to devices. Occupations identified with high scores on these job dimensions included transportation jobs (air traffic controllers, airline pilots and attendants, bus drivers, locomotive engineers, truck drivers), teachers (preschool, adult education), and craftsmen/foremen (machinists, carpenters, and foremen). JF - Journal of clinical epidemiology AU - Murphy, L R AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 155 EP - 166 VL - 44 IS - 2 SN - 0895-4356, 0895-4356 KW - Index Medicus KW - Environment KW - Age Factors KW - Discriminant Analysis KW - Educational Status KW - Sex Factors KW - Humans KW - Interpersonal Relations KW - Marriage KW - Risk Factors KW - Mental Processes KW - Physical Exertion KW - Adult KW - Databases, Factual KW - Middle Aged KW - Female KW - Male KW - Stress, Psychological -- complications KW - Cardiovascular Diseases -- etiology KW - Occupational Diseases -- etiology KW - Job Description KW - Disabled Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80451933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Job+dimensions+associated+with+severe+disability+due+to+cardiovascular+disease.&rft.au=Murphy%2C+L+R&rft.aulast=Murphy&rft.aufirst=L&rft.date=1991-01-01&rft.volume=44&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-27 N1 - Date created - 1991-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pesticide residues in foods imported into the United States. AN - 80442756; 1994461 AB - Interest in pesticide residues in foods has increased, and the issue of residues in imported foods has been raised as a potential public health problem. Three U.S. government agencies, EPA, FDA, and USDA, are responsible for regulating pesticides. EPA sets tolerances, and FDA and USDA enforce those tolerances. As part of its regulatory activities, FDA conducts a regulatory monitoring program that samples and analyzes each year approximately 20,000 food shipments, about 60% of which are imports. Samples of imported foods are collected at ports of entry, and are chosen on the basis of several factors rather than on a completely random basis. Raw agricultural products are emphasized. Most analyses are performed using MRMs, to make best use of FDA's resources. Using five MRMs, about half of the 300 pesticides with U.S. tolerances can be determined. Results from monitoring over the past several years have shown that nearly 60% of the imported foods sampled had no pesticide residues detected. Of those samples that were violative, 5% contained residues for which there was no U.S. tolerance, and less than 1% had over-tolerance residues. Examples are given of the various pesticide/commodity combinations that have been found to be violative. FDA is often criticized for the scope of its pesticide coverage, particularly with regard to imported foods. Some critics have promoted the idea of a 'circle of poison,' which is based on the premise that pesticides banned in the U.S. are exported and used on foods in foreign countries; then the food containing these residues is imported into the U.S. and consumed. However, FDA's testing of imported foods has shown that residues of EPA-banned pesticides are not occurring from currently purposeful uses. The violation rates for imports also have not been significantly different from those for domestic foods. This indicates that foreign producers, as well as domestic growers, generally use pesticides in a manner consistent with EPA requirements. FDA continues to broaden its information-gathering capabilities. As mandated by the PMIA of 1988, FDA will attempt to obtain pesticide use information from countries that are major food exporters to the United States. An improved data management system will also be in place, and a long-range analytical method development plan instituted. Several international organizations address the issue of pesticide residues in foods. Attempts at harmonization of national tolerances for pesticide residues have not been successful, i.e., a number of individual nations have not accepted Codex MRLs.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Reviews of environmental contamination and toxicology AU - Wessel, J R AU - Yess, N J AD - Food and Drug Administration, Office of Regulatory Affairs, Rockville, MD 20857. Y1 - 1991 PY - 1991 DA - 1991 SP - 83 EP - 104 VL - 120 SN - 0179-5953, 0179-5953 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - United States Environmental Protection Agency KW - Humans KW - Government Agencies KW - Legislation, Drug KW - Food Contamination -- analysis KW - Pesticide Residues -- analysis KW - Food Supply -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80442756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+environmental+contamination+and+toxicology&rft.atitle=Pesticide+residues+in+foods+imported+into+the+United+States.&rft.au=Wessel%2C+J+R%3BYess%2C+N+J&rft.aulast=Wessel&rft.aufirst=J&rft.date=1991-01-01&rft.volume=120&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Reviews+of+environmental+contamination+and+toxicology&rft.issn=01795953&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-18 N1 - Date created - 1991-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenic potency correlations: real or artifactual? AN - 80418481; 1987359 AB - It has been suggested by various investigators that observed interspecies correlations of carcinogenic potency estimates based on bioassays are to a degree due to tautologous aspects of experimental designs. Some authors have even suggested that carcinogenic potency estimates derived from chronic bioassays are little more than experimental design artifacts. In this paper it is argued that constraints imposed by the use of the one-hit model to estimate carcinogenic potency are more restrictive than potential experimental design constraints. JF - Journal of toxicology and environmental health AU - Kodell, R L AU - Gaylor, D W AU - Chen, J J AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 1 EP - 9 VL - 32 IS - 1 SN - 0098-4108, 0098-4108 KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Female KW - Carcinogenicity Tests -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80418481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Carcinogenic+potency+correlations%3A+real+or+artifactual%3F&rft.au=Kodell%2C+R+L%3BGaylor%2C+D+W%3BChen%2C+J+J&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-01-01&rft.volume=32&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-21 N1 - Date created - 1991-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of the in vitro unscheduled DNA synthesis assay in primary lung cells of the rat. AN - 80364192; 1986285 AB - The in vitro unscheduled DNA synthesis (UDS) assay has been evaluated in rat primary lung cells with known genotoxicants. The autoradiographic method was employed to detect UDS in both alveolar macrophages and primary pulmonary cells. Data of a time course study revealed that a high radioactive labeling of DNA repair was achieved after a 16-h incubation with [3H]thymidine. Coupled with low serum (1%), hydroxyurea at the concentration of 20 mM inhibited regular DNA synthesis in primary lung cells in a satisfactory manner (81-88% inhibition). With this protocol, a dose-related increase in UDS was induced by N-methyl-N'-nitro-N-nitrosoguanidine and 2-aminoanthracene in both rat alveolar macrophages and primary lung cells. The results suggest that primary rat lung cells in culture possess DNA-repair ability and that the UDS assay may be useful for assessing the pulmonary genotoxic effect of chemicals in this cell system. JF - Mutation research AU - Whong, W Z AU - Stewart, J D AU - Ong, T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 51 EP - 55 VL - 262 IS - 1 SN - 0027-5107, 0027-5107 KW - Anthracenes KW - 0 KW - Mutagens KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - 2-anthramine KW - 8240818JGU KW - DNA KW - 9007-49-2 KW - Hydroxyurea KW - X6Q56QN5QC KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Anthracenes -- pharmacology KW - Dose-Response Relationship, Drug KW - Methylnitronitrosoguanidine -- pharmacology KW - In Vitro Techniques KW - Hydroxyurea -- pharmacology KW - Mutagens -- pharmacology KW - Autoradiography KW - Male KW - Macrophages -- metabolism KW - Mutagenicity Tests -- methods KW - Lung -- metabolism KW - DNA -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80364192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Characterization+of+the+in+vitro+unscheduled+DNA+synthesis+assay+in+primary+lung+cells+of+the+rat.&rft.au=Whong%2C+W+Z%3BStewart%2C+J+D%3BOng%2C+T&rft.aulast=Whong&rft.aufirst=W&rft.date=1991-01-01&rft.volume=262&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-12 N1 - Date created - 1991-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral contraceptive estrogen dose and the risk of deep venous thromboembolic disease. AN - 80358726; 1983896 AB - Despite the well-recognized association between oral contraceptives and deep venous thromboembolism, little is known about the risks associated with currently marketed formulations containing less than 50 micrograms of estrogen. To assess the venous thrombogenicity of low-estrogen oral contraceptives (those containing less than 50 micrograms of estrogen) relative to intermediate-dose (50 micrograms of estrogen) and high-dose (greater than 50 micrograms of estrogen) formulations, we conducted a cohort study of oral contraceptive users between the ages of 15 and 44 years in the Michigan Medicaid population. The period of the study was from 1980 through the third quarter of 1986. A total of 2,739,400 oral contraceptive prescriptions received by 234,218 women were analyzed. Using the low-estrogen cohort as the referent group, the age and calendar period adjusted relative risk of venous thromboembolism in users of intermediate-dose formulations was 1.5 (95% confidence interval (CI) 1.0-2.1, p = 0.04), and the relative risk in users of high-dose formulations was 1.7 (95% CI 0.9-3.0, p = 0.06). These data provide evidence that the dose-response relation between oral contraceptive estrogen and venous thromboembolism extends from 50 to 30 micrograms of estrogen, the dose range of currently marketed formulations. JF - American journal of epidemiology AU - Gerstman, B B AU - Piper, J M AU - Tomita, D K AU - Ferguson, W J AU - Stadel, B V AU - Lundin, F E AD - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 32 EP - 37 VL - 133 IS - 1 SN - 0002-9262, 0002-9262 KW - Contraceptives, Oral KW - 0 KW - Estrogens KW - Index Medicus KW - Risk Factors KW - Humans KW - Confounding Factors (Epidemiology) KW - Female KW - Contraceptives, Oral -- administration & dosage KW - Thromboembolism -- epidemiology KW - Chemistry, Pharmaceutical -- statistics & numerical data KW - Thromboembolism -- chemically induced KW - Estrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80358726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Oral+contraceptive+estrogen+dose+and+the+risk+of+deep+venous+thromboembolic+disease.&rft.au=Gerstman%2C+B+B%3BPiper%2C+J+M%3BTomita%2C+D+K%3BFerguson%2C+W+J%3BStadel%2C+B+V%3BLundin%2C+F+E&rft.aulast=Gerstman&rft.aufirst=B&rft.date=1991-01-01&rft.volume=133&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-17 N1 - Date created - 1991-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Epidemiol. 1991 Nov 1;134(9):1009; author reply 1009-10 [1951289] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of micronuclei in rat bone marrow by four model compounds. AN - 72750957; 1687903 AB - Studies have been performed to determine the dose and sampling time responses of micronuclei after Sprague-Dawley rats were treated with triethylenemelamine, mitomycin C. dimethylbenzanthracene, and vincristine by a single intraperitoneal injection. Three doses were tested for each compound. Animals were sacrificed 24, 48, and 72 h after chemical treatment. Slides prepared from the bone marrow were stained with May-Gruenwald and Giemsa stains. The number of micronucleated polychromatic erythrocytes among 2,000 polychromatic erythrocytes (PCEs) and the ratio of PCEs to normochromatic erythrocytes were determined for each animal. The results show that all four compounds cause micronucleus formation in rat bone marrow. The peak response sampling time, either 24 or 48 h posttreatment, is dependent on the chemical as well as the dose. In all cases, however, an increase in the micronucleated PCEs was detected 24 h after chemical treatment. These results seem to indicate that two sampling times, 24 and 48 h, may be adequate for the micronucleus assay using rat bone marrow cells. JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Shi, X C AU - Krishna, G AU - Ong, T M AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888. Y1 - 1991 PY - 1991 DA - 1991 SP - 251 EP - 258 VL - 11 IS - 5 SN - 0270-3211, 0270-3211 KW - Mitomycin KW - 50SG953SK6 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Vincristine KW - 5J49Q6B70F KW - Triethylenemelamine KW - F7IY6HZG9D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Erythrocytes -- drug effects KW - Animals KW - Micronucleus Tests KW - Time Factors KW - Male KW - Triethylenemelamine -- toxicity KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Mitomycin -- toxicity KW - Bone Marrow -- ultrastructure KW - Bone Marrow -- drug effects KW - Vincristine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Induction+of+micronuclei+in+rat+bone+marrow+by+four+model+compounds.&rft.au=Shi%2C+X+C%3BKrishna%2C+G%3BOng%2C+T+M&rft.aulast=Shi&rft.aufirst=X&rft.date=1991-01-01&rft.volume=11&rft.issue=5&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-30 N1 - Date created - 1992-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative study of micronucleus assay and chromosomal aberration analysis in V79 cells exposed to ethylene oxide. AN - 72750926; 1687900 AB - Micronucleus formation and chromosomal aberration (CA) in V79 cells were compared for their sensitivity in response to ethylene oxide (EtO) treatment. The results indicate that EtO exposure for 30 min induced CAs in V79 cells at the concentration of 3,500 ppm or higher. A statistically significant difference (P less than 0.01) was found between treated and control groups at all concentrations tested based on percent aberrant cells. The increase was dose-dependent with a correlation coefficient of 0.88. The aberrations found include chromatid and isochromatid breaks, fragments, minutes, and exchanges. Results of the micronucleus assay both in mononucleated and binucleated cells showed a slight but not statistically significant increase in micronuclei with doses between 457 to 4115 ppm. At the highest concentration tested (12344 ppm) EtO caused a significant increase in the micronucleus frequency (P less than 0.05). JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Zhong, B Z AU - Gu, Z W AU - Whong, W Z AU - Wallace, W E AU - Ong, T M AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888. Y1 - 1991 PY - 1991 DA - 1991 SP - 227 EP - 233 VL - 11 IS - 5 SN - 0270-3211, 0270-3211 KW - Ethylene Oxide KW - JJH7GNN18P KW - Index Medicus KW - Animals KW - Cricetulus KW - Lung KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Cell Division -- drug effects KW - Male KW - Cricetinae KW - Fibroblasts -- drug effects KW - Micronucleus Tests KW - Chromosome Aberrations KW - Fibroblasts -- ultrastructure KW - Ethylene Oxide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Comparative+study+of+micronucleus+assay+and+chromosomal+aberration+analysis+in+V79+cells+exposed+to+ethylene+oxide.&rft.au=Zhong%2C+B+Z%3BGu%2C+Z+W%3BWhong%2C+W+Z%3BWallace%2C+W+E%3BOng%2C+T+M&rft.aulast=Zhong&rft.aufirst=B&rft.date=1991-01-01&rft.volume=11&rft.issue=5&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-30 N1 - Date created - 1992-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The epidemiology of populations exposed to dioxin. AN - 72750777; 1817104 JF - IARC scientific publications AU - Fingerhut, M A AU - Sweeney, M H AU - Halperin, W E AU - Schnorr, T M AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 31 EP - 50 IS - 108 SN - 0300-5038, 0300-5038 KW - Carcinogens, Environmental KW - 0 KW - Dioxins KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Dioxins -- adverse effects KW - Carcinogens, Environmental -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=The+epidemiology+of+populations+exposed+to+dioxin.&rft.au=Fingerhut%2C+M+A%3BSweeney%2C+M+H%3BHalperin%2C+W+E%3BSchnorr%2C+T+M&rft.aulast=Fingerhut&rft.aufirst=M&rft.date=1991-01-01&rft.volume=&rft.issue=108&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-07 N1 - Date created - 1992-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of pneumoconiosis interpretation between Chinese and American readers and classifications. AN - 72741224; 1819033 AB - As a preliminary step in joint Sino-American pneumoconiosis research efforts, a formal chest X-ray pneumoconiosis reading trial was conducted among Chinese and American radiologists. Twelve Chinese readers from different institutions located in south central China used the 1986 Chinese Roentgenodiagnostic Criteria of Pneumoconioses. Three American radiologists, centified as NIOSH "B" readers, used the International Labour Office Classification of Pneumoconioses. The chest X-ray study set consisted of 150 posterior-anterior films. One-half were Chinese X-rays of silica-exposed workers, and the other half were American films of variously exposed workers but primarily coal miners. All readings were done independently. The results showed that the inter-reader variability among the Chinese was similar to that of the American readers, both being in an acceptable range. In addition, there was general agreement between the Chinese and American interpretations. For small opacity profusion, the Chinese readers tended to read slightly more diseases than their American counterparts, although there was exact agreement as to the major category in two-thirds of the films. Agreement for film quality, and pleural disease was less, but was not different from reported variation among American "B" readers. Overall, the results suggest that despite the use of two different classification systems, a valid correspondence exists between the Chinese and American Interpretations, which is suitable for use in epidemiologic research. JF - Journal of Tongji Medical University = Tong ji yi ke da xue xue bao AU - Hodous, T K AU - Chen, R A AU - Kinsley, K B AU - Liu, X T AU - McLaughlin, J K AU - Chen, J Q AU - Wu, Z E AU - Blot, W J AD - Division of Respiratory Disease Studies, NIOSH, Morgantown, WV. Y1 - 1991 PY - 1991 DA - 1991 SP - 225 EP - 229 VL - 11 IS - 4 SN - 0257-716X, 0257-716X KW - Index Medicus KW - United States KW - Silicosis -- diagnostic imaging KW - Humans KW - Reference Standards KW - Anthracosilicosis -- diagnostic imaging KW - Coal Mining KW - Radiography KW - China KW - Pneumoconiosis -- diagnostic imaging KW - Pneumoconiosis -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72741224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Tongji+Medical+University+%3D+Tong+ji+yi+ke+da+xue+xue+bao&rft.atitle=A+comparison+of+pneumoconiosis+interpretation+between+Chinese+and+American+readers+and+classifications.&rft.au=Hodous%2C+T+K%3BChen%2C+R+A%3BKinsley%2C+K+B%3BLiu%2C+X+T%3BMcLaughlin%2C+J+K%3BChen%2C+J+Q%3BWu%2C+Z+E%3BBlot%2C+W+J&rft.aulast=Hodous&rft.aufirst=T&rft.date=1991-01-01&rft.volume=11&rft.issue=4&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Tongji+Medical+University+%3D+Tong+ji+yi+ke+da+xue+xue+bao&rft.issn=0257716X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-21 N1 - Date created - 1992-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of Drosophila for screening developmental toxicants: test results with eighteen chemicals and presentation of a new Drosophila bioassay. AN - 72685917; 1686822 AB - The objective of this study was to generate a comprehensive data set of chemically induced malformations in Drosophila using a detailed morphological examination of the entire fly (phase one). These data were analyzed, in blind, with the goal of developing a standardized set of criteria which could be used in a new, rapid, and economical Drosophila bioassay useful in the preliminary screening for potential developmental toxicants. After 32 chemicals were tested, formalized criteria were developed to form the basis of a new Drosophila bioassay. These criteria were then applied to the data from the same 32 chemicals (phase two). The data from only 18 of these chemicals met all requirements for evaluation, e.g., statistical significance, minimum fly numbers, sufficient challenge concentration administered, etc. In the new bioassay, rather than the detailed and time-consuming examination of the entire fly for a multitude of morphological defects, only two specific anatomical sites are examined. These sites are the humeral bristle and the wing blade, with focus placed on two structural defects--a bent bristle and a notch in the wing. These defects were the only two external malformations among the multitude of defects observed in flies treated in the first phase with the 32 chemicals which demonstrated the following characteristics: 1) A consistent concentration-response in flies treated with a variety of developmental toxicants; 2) a lack of response with most presumptive non-developmental toxicants; and 3) consistently low-background incidences in control flies. In both phases, developing Drosophila were exposed to the test agents from the egg through three larval stages by incorporating a range of concentrations of each chemical into the culture medium. Emerging adults were examined for an array of defects as part of a detailed morphological examination in the first phase, including bent bristles and wing notches. In the second phase, only bent bristle and wing notch data were evaluated. The incidences of bent humeral bristles and wing notches from flies exposed to each of the 18 chemicals were compared with those of concurrent controls. Of the 18 chemicals that could be evaluated using the new bioassay, 13 were known developmental toxicants while the remaining 5 were presumptive negative agents. Ten of the 13 mammalian developmental toxicants were correctly identified with this test (false negative rate of 23%). Four of five apparent non-developmental toxicants were correctly identified for a false positive rate of 20%.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Lynch, D W AU - Schuler, R L AU - Hood, R D AU - Davis, D G AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226-1998. Y1 - 1991 PY - 1991 DA - 1991 SP - 147 EP - 173 VL - 11 IS - 3 SN - 0270-3211, 0270-3211 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Dose-Response Relationship, Drug KW - Biological Assay -- methods KW - Drosophila melanogaster -- growth & development KW - Abnormalities, Drug-Induced KW - Drosophila melanogaster -- drug effects KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72685917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Evaluation+of+Drosophila+for+screening+developmental+toxicants%3A+test+results+with+eighteen+chemicals+and+presentation+of+a+new+Drosophila+bioassay.&rft.au=Lynch%2C+D+W%3BSchuler%2C+R+L%3BHood%2C+R+D%3BDavis%2C+D+G&rft.aulast=Lynch&rft.aufirst=D&rft.date=1991-01-01&rft.volume=11&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-13 N1 - Date created - 1992-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of rat lymphocyte activation of benzo[a]pyrene, 2-acetylaminofluorene, and several of their metabolites to mutagenic and DNA-damaging species in vitro. AN - 72668891; 1686675 AB - Rat lymphocytes are a potentially useful and convenient cell system for monitoring the genotoxic effects of chemicals in vivo, but little is known about the ability of these cells to metabolize promutagens to genotoxic species. In this study, Fischer 344 rat lymphocytes were treated in vitro with benzo[a]pyrene (BaP), 2-acetylaminofluorene (2-AAF), and several of their metabolites, and DNA damage was measured using nucleoid sedimentation analysis. Of the BaP derivatives, BaP 4,5-oxide and BaP 7,8-diol-9, 10-epoxide decreased lymphocyte nucleoid sedimentation, whereas BaP and BaP 7,8-dihydrodiol had little effect. Among the 2-AAF derivatives, N-acetoxy-2-AAF, N-hydroxy-2-AAF, and N-hydroxy-2-aminofluorene damaged rat lymphocyte nucleoids, whereas 2-AAF, 2-aminofluorene, and fluorene produced little detectable damage. The decrease in nucleoid sedimentation produced by N-hydroxy-2-AAF was not inhibited by paraoxon, salicylamide, or 2-aminofluorene, whereas paraoxon inhibited damage produced by N-acetoxy-2-AAF. In co-culture assays, rat lymphocytes increased the mutagenicity of N-hydroxy-2-AAF in Salmonella typhimurium strain TA98, but mediated little or no mutagenic response with BaP, BaP 7,8-dihydrodiol, and 2-AAF. Also, human lymphocytes, but not rat lymphocytes, mediated a positive mutagenic response with BaP 7,8-dihydrodiol in Chinese hamster ovary UV5 cells. Although rat lymphocytes may metabolize certain proximal genotoxic chemicals to DNA-damaging species (e.g., N-hydroxy-2-AAF), these data suggest that in vivo lymphocyte DNA damage is more likely to result from lymphocytes encountering reactive chemical derivatives produced by other cells. It is also clear that differences exist between the ability of human and rat lymphocytes to activate promutagens, and this may impact on the use of the rat model to predict the genotoxicity of chemicals in humans. JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Gao, N AU - Aidoo, A AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 65 EP - 76 VL - 11 IS - 2 SN - 0270-3211, 0270-3211 KW - DNA, Superhelical KW - 0 KW - Mutagens KW - Benzo(a)pyrene KW - 3417WMA06D KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - CHO Cells -- metabolism KW - Cells, Cultured KW - Biotransformation KW - Salmonella typhimurium -- drug effects KW - DNA, Superhelical -- metabolism KW - Male KW - Cricetinae KW - 2-Acetylaminofluorene -- metabolism KW - DNA Damage KW - Mutagens -- metabolism KW - Lymphocytes -- metabolism KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72668891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Analysis+of+rat+lymphocyte+activation+of+benzo%5Ba%5Dpyrene%2C+2-acetylaminofluorene%2C+and+several+of+their+metabolites+to+mutagenic+and+DNA-damaging+species+in+vitro.&rft.au=Gao%2C+N%3BAidoo%2C+A%3BHeflich%2C+R+H&rft.aulast=Gao&rft.aufirst=N&rft.date=1991-01-01&rft.volume=11&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-06 N1 - Date created - 1992-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contribution of biological markers to occupational health. AN - 72659358; 1785610 AB - Occupational diseases are now being assessed at the cellular and molecular levels; this presents new opportunities for prevention and control [Calleman et al., 1978; Ong et al., 1987; Stejskal et al., 1989; Welch and Cullen, 1988; Garry et al., 1989]. The key to these opportunities is the ability to detect biological markers that reflect exposure, response, and susceptibility. Biological markers are not new, however. Biological markers such as blood lead, urinary phenol levels in benzene exposure, and liver function assays have long been used in occupational and public health research and practice. What distinguishes the current generation of markers from previous markers is a greater degree of analytical sensitivity and the ability to describe events that occur earlier in the progression between exposure and clinical disease. There are now new domains of response that were not known to exist 20 years ago. Accompanying this sensitivity is the increased requirement to consider the numerous factors that can influence the appearance of biological markers. It has been observed that all workers with similar exposures do not develop disease or markers indicative of exposure or disease. Various acquired and hereditary host factors are responsible for this variation in responses. The role of assessing the nature and degree of variation between individuals is of paramount importance. Finally, the use of biological markers in occupational health research and practice also brings new ethical and legal considerations into high profile. This paper presents my personal opinions on how biological markers can contribute to occupational health efforts and the new requirements that they bring to the field. As with any technological change, the more we can anticipate the impact, the better our ability to adjust. JF - American journal of industrial medicine AU - Schulte, P A AD - Screening & Notification Section, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. Y1 - 1991 PY - 1991 DA - 1991 SP - 435 EP - 446 VL - 20 IS - 4 SN - 0271-3586, 0271-3586 KW - Biomarkers KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Environmental Monitoring KW - Reproducibility of Results KW - Humans KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Ethics, Medical KW - Occupational Exposure -- adverse effects KW - Disease Models, Animal KW - Occupational Diseases -- epidemiology KW - Epidemiological Monitoring KW - Research KW - Occupational Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72659358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Contribution+of+biological+markers+to+occupational+health.&rft.au=Schulte%2C+P+A&rft.aulast=Schulte&rft.aufirst=P&rft.date=1991-01-01&rft.volume=20&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-17 N1 - Date created - 1992-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - On the mechanism of action of interferons: interaction with nonsteroidal anti-inflammatory agents, pentoxifylline (Trental) and cGMP inducers. AN - 72648030; 1664849 AB - In earlier studies, we showed that when interferon alpha (IFN alpha) binds to cell receptors, it alters membrane potentials. In IFN-sensitive Daudi cells derived from Burkitt's lymphoma patients, IFNs produce dose-dependent hyperpolarization, decreased plasma membrane viscosity, modulation of the microfilament system, and altered synthesis of cAMP, cGMP and prostaglandins. No such changes were seen in IFN alpha-resistant Daudi cells. In this study, we found that indomethacin, pentoxifylline, or the cGMP inducer sodium azide (NaN3) had no significant effect on the IFN alpha induced membrane potential changes, or on membrane viscosity changes as measured by flow cytometry and electron spin resonance spectrometry. In tissue culture, indomethacin did not alter the anti-proliferative effect of IFN alpha on Daudi cells. Indomethacin may influence IFN synthesis, but not it's antiproliferative actions. Relatively high doses of pentoxifylline slightly inhibited proliferation of Daudi cells and synergized with IFN alpha. Measurement of early biophysical changes induced by IFNs may represent a new screening method to rapidly explore certain types of IFN alpha potentiating agents. JF - Journal of medicine AU - Aszalos, A AU - Grimley, P M AU - Balint, E AU - Chadha, K C AU - Ambrus, J L AD - Division of Research and Testing, FDA, Washington, DC. Y1 - 1991 PY - 1991 DA - 1991 SP - 255 EP - 271 VL - 22 IS - 4-5 SN - 0025-7850, 0025-7850 KW - Azides KW - 0 KW - Interferon-alpha KW - Sodium Azide KW - 968JJ8C9DV KW - Cyclic GMP KW - H2D2X058MU KW - Pentoxifylline KW - SD6QCT3TSU KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Drug Interactions KW - Cyclic GMP -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Electron Spin Resonance Spectroscopy KW - In Vitro Techniques KW - Membrane Potentials -- drug effects KW - Burkitt Lymphoma -- pathology KW - Pentoxifylline -- pharmacology KW - Interferon-alpha -- metabolism KW - Azides -- pharmacology KW - Interferon-alpha -- physiology KW - Indomethacin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72648030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicine&rft.atitle=On+the+mechanism+of+action+of+interferons%3A+interaction+with+nonsteroidal+anti-inflammatory+agents%2C+pentoxifylline+%28Trental%29+and+cGMP+inducers.&rft.au=Aszalos%2C+A%3BGrimley%2C+P+M%3BBalint%2C+E%3BChadha%2C+K+C%3BAmbrus%2C+J+L&rft.aulast=Aszalos&rft.aufirst=A&rft.date=1991-01-01&rft.volume=22&rft.issue=4-5&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicine&rft.issn=00257850&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-24 N1 - Date created - 1992-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Infectious diseases and drug abuse. Prevention and treatment in the drug abuse treatment system. AN - 72644717; 1787552 AB - Several communicable infectious diseases, including AIDS, hepatitis B infection, gonorrhea, syphilis, and tuberculosis, are increasing among drug abusers. Drug abuse treatment programs may be ideal sites to identify those infections and initiate and maintain appropriate medical management. This paper reviews the epidemiology of those infections among drug abusers in the USA, presents rudimentary aspects of medical management of selected infectious diseases, and discusses the need to integrate infectious diseases, drug abuse treatment, and public health approaches if we are to reverse, or at least stabilize, the trends of those diseases. JF - Journal of substance abuse treatment AU - Haverkos, H W AD - Division of Clinical Research, National Institute on Drug Abuse, United States Public Health Service, Rockville, Maryland 20857. Y1 - 1991 PY - 1991 DA - 1991 SP - 269 EP - 275 VL - 8 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - AIDS/HIV KW - Gonorrhea -- transmission KW - Hepatitis B -- prevention & control KW - HIV Infections -- transmission KW - Risk Factors KW - Humans KW - HIV Infections -- prevention & control KW - Tuberculosis, Pulmonary -- transmission KW - Tuberculosis, Pulmonary -- prevention & control KW - Syphilis -- transmission KW - Syphilis -- prevention & control KW - Hepatitis B -- transmission KW - Gonorrhea -- prevention & control KW - Communicable Disease Control -- methods KW - Substance Abuse, Intravenous -- rehabilitation KW - Substance Abuse, Intravenous -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72644717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Infectious+diseases+and+drug+abuse.+Prevention+and+treatment+in+the+drug+abuse+treatment+system.&rft.au=Haverkos%2C+H+W&rft.aulast=Haverkos&rft.aufirst=H&rft.date=1991-01-01&rft.volume=8&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-23 N1 - Date created - 1992-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins. AN - 72622463; 1778307 AB - A synthetic peptide corresponding to amino acids 6-17 of the A subunit of pertussis toxin was synthesised and used for the immunization of Balb/c mice and the subsequent production of monoclonal antibodies (MAbs). This peptide contains a region of eight amino acids which is homologous to a region in the cholera toxin A subunit. The properties of two of the resultant MAbs are described. Both of the antibodies (CP7-3003F7, an IgG3 and CP7-3004G6X1, an IgG1) react in an ELISA with the peptide and with intact pertussis toxin, pertussis toxin A subunit and cholera toxin A subunit, but do not react significantly with pertussis toxin B subunit, intact cholera toxin, or cholera toxin B subunit. Competition ELISA assays in which the peptide, the intact toxins and the toxin subunits were compared with respect to their ability to inhibit the binding of the MAbs to peptide-coated ELISA plates demonstrated that only pertussis toxin A subunit was as active, on a molar basis, as the peptide. Western blot analyses of the holotoxins confirmed that both MAbs were reactive only with the toxin A subunits. The MAbs were unable to neutralize the activity of cholera toxin or pertussis toxin in a Chinese hamster ovary (CHO) cell assay. Both were also unable to neutralize either the ADP-ribosylation activity or the NAD-glycohydrolase activity of the pertussis toxin A subunit. The significance of these results with respect to the role of this conserved site in the activity of these two toxins is discussed. JF - Developments in biological standardization AU - Kenimer, J G AU - Probst, P G AU - Karpas, A B AU - Burns, D L AU - Kaslow, H R AD - Laboratory of Cellular Physiology, CBER, FDA, Bethesda, MD 20892. Y1 - 1991 PY - 1991 DA - 1991 SP - 133 EP - 141 VL - 73 SN - 0301-5149, 0301-5149 KW - Antibodies, Monoclonal KW - 0 KW - Peptides KW - Virulence Factors, Bordetella KW - Cholera Toxin KW - 9012-63-9 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Index Medicus KW - Animals KW - Peptides -- immunology KW - Poly(ADP-ribose) Polymerases -- immunology KW - Amino Acid Sequence KW - Mice KW - Mice, Inbred BALB C KW - Molecular Weight KW - Molecular Sequence Data KW - Neutralization Tests KW - CHO Cells KW - Enzyme-Linked Immunosorbent Assay KW - Peptides -- chemistry KW - Cricetinae KW - Virulence Factors, Bordetella -- metabolism KW - Virulence Factors, Bordetella -- chemistry KW - Cholera Toxin -- immunology KW - Virulence Factors, Bordetella -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72622463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developments+in+biological+standardization&rft.atitle=Monoclonal+antibodies+against+the+enzymatic+subunit+of+both+pertussis+and+cholera+toxins.&rft.au=Kenimer%2C+J+G%3BProbst%2C+P+G%3BKarpas%2C+A+B%3BBurns%2C+D+L%3BKaslow%2C+H+R&rft.aulast=Kenimer&rft.aufirst=J&rft.date=1991-01-01&rft.volume=73&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Developments+in+biological+standardization&rft.issn=03015149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-10 N1 - Date created - 1992-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS knowledge, perception of risk, and behaviors among female sex partners of injection drug users. AN - 72619215; 1777343 AB - Interviews were conducted with 137 female sex partners of male injection drug users to provide quantitative and qualitative information regarding their AIDS knowledge, attitudes, and specific risk behaviors. Levels of knowledge regarding HIV transmission and prevention were high, with an average of 81.8% correct on a 16-item test. Most women (87.5%) believed that there was at least some chance they would become HIV infected. Substance abuse was prevalent; 67.2% used non-injection drugs (44.5% used crack cocaine), and 32.1% reported prior use of injection drugs. One fifth had engaged in prostitution. Although AIDS knowledge was high, almost all (94.9%) reported engaging in unprotected vaginal intercourse during the previous 6 months, and 6.6% reported anal intercourse without a condom. Among women who did not report consistent condom use, the most frequently stated reasons for non-use of condoms were dislike by their male partner (26.9%) and/or personal dislike of condoms (23.1%). A disturbing pattern of increased risk was observed among black interviewees, who were more likely than Latinas or whites to have contracted syphilis, have multiple sex partners, engage in prostitution, use crack cocaine, and drink alcohol daily. JF - AIDS education and prevention : official publication of the International Society for AIDS Education AU - Corby, N H AU - Wolitski, R J AU - Thornton-Johnson, S AU - Tanner, W M AD - Long Beach Department of Health and Human Services, CA 90806. Y1 - 1991 PY - 1991 DA - 1991 SP - 353 EP - 366 VL - 3 IS - 4 SN - 0899-9546, 0899-9546 KW - Index Medicus KW - AIDS/HIV KW - Contraceptive Devices, Male -- utilization KW - Risk-Taking KW - Humans KW - European Continental Ancestry Group -- psychology KW - Sexual Behavior KW - African Americans -- psychology KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Hispanic Americans -- psychology KW - Adolescent KW - Urban Population KW - California -- epidemiology KW - Female KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Acquired Immunodeficiency Syndrome -- transmission KW - Health Knowledge, Attitudes, Practice KW - Sexual Partners -- psychology KW - Substance Abuse, Intravenous -- complications KW - Acquired Immunodeficiency Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72619215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention+%3A+official+publication+of+the+International+Society+for+AIDS+Education&rft.atitle=AIDS+knowledge%2C+perception+of+risk%2C+and+behaviors+among+female+sex+partners+of+injection+drug+users.&rft.au=Corby%2C+N+H%3BWolitski%2C+R+J%3BThornton-Johnson%2C+S%3BTanner%2C+W+M&rft.aulast=Corby&rft.aufirst=N&rft.date=1991-01-01&rft.volume=3&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention+%3A+official+publication+of+the+International+Society+for+AIDS+Education&rft.issn=08999546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nuclear protein phosphorylation in rat cerebral cells following acute exposure to ethanol. AN - 72564840; 1756189 AB - The sequelae of acute ethanol toxicity encompass a broad spectrum of metabolic and cellular derangements, including the induction of stress proteins in cells exposed to high levels of ethanol. In this investigation, the effects of ethanol exposure on nuclear protein synthesis and phosphorylation were compared by two-dimensional gel electrophoresis in glial-enriched cultures, adult rat cerebrum and regenerated liver. Cellular exposure to ethanol was at clinically relevant levels and tissue was analyzed at 1 h and 48 h after exposure. Cell nuclei were stained with propidium iodide, a DNA specific fluorochrome and flow cytometrically sorted to obtain cell cycle phase populations of nuclei for analysis. Ethanol treatment of intact rats and glial-enriched cultures induced phosphorylation of specific nuclear proteins, which were detected by two-dimensional electrophoresis and autoradiography. The autoradiographs of [32P]phosphate and [3H]leucine labeled proteins from glial-enriched cultures and from the G0/G1 phase of the regenerating liver tissue exhibited intense labeling indicative of active protein synthesis and phosphorylation. In contrast, the autoradiographs of proteins from adult rat cerebra showed substantial phosphorylation, but weak protein synthesis. Ethanol treatment was associated with phosphorylation of a 50,000 Mr protein in G0/G1 phase cells of the cultures and in predominantly G0 cells of the adult rat cerebra. A protein with similar characteristics was not found in ethanol exposed regenerating rat liver tissue and has not been observed in other 'heat shock' or 'stress' protein systems which we have previously studied. JF - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society AU - Hinson, W G AU - Pipkin, J L AU - Anson, J F AU - Davies, D L AU - Burns, E R AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72205-9502. Y1 - 1991 PY - 1991 DA - 1991 SP - 93 EP - 99 VL - 2 IS - 2-3 SN - 0954-6642, 0954-6642 KW - Indicators and Reagents KW - 0 KW - Nuclear Proteins KW - Phosphates KW - Phosphoproteins KW - Phosphorus Radioisotopes KW - Tritium KW - 10028-17-8 KW - Ethanol KW - 3K9958V90M KW - Leucine KW - GMW67QNF9C KW - Index Medicus KW - Animals KW - Electrophoresis, Gel, Two-Dimensional -- methods KW - Liver -- metabolism KW - Liver Regeneration KW - Molecular Weight KW - Rats, Inbred Strains KW - Rats KW - Phosphates -- metabolism KW - Phosphorylation KW - Cells, Cultured KW - Kinetics KW - Leucine -- metabolism KW - Female KW - Neuroglia -- metabolism KW - Nuclear Proteins -- isolation & purification KW - Ethanol -- pharmacology KW - Brain -- pathology KW - Brain -- drug effects KW - Ethanol -- toxicity KW - Brain -- metabolism KW - Neuroglia -- drug effects KW - Phosphoproteins -- isolation & purification KW - Nuclear Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72564840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Nuclear+protein+phosphorylation+in+rat+cerebral+cells+following+acute+exposure+to+ethanol.&rft.au=Hinson%2C+W+G%3BPipkin%2C+J+L%3BAnson%2C+J+F%3BDavies%2C+D+L%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Hinson&rft.aufirst=W&rft.date=1991-01-01&rft.volume=2&rft.issue=2-3&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-04 N1 - Date created - 1992-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of Salmonella typhimurium hisD3052 revertants: the use of oligodeoxyribonucleotide colony hybridization, PCR, and direct sequencing in mutational analysis. AN - 72561862; 1748083 AB - A rapid method for determining the DNA sequences of Salmonella typhimurium hisD3052 revertants is presented. DNA colony hybridization was used to analyze revertants previously studied by Isono and Yourno [Proc Natl Acad Sci USA 71:1612-1617, 1974]. Synthetic oligodeoxyribonucleotide probes (18-mers) were able to distinguish sequences that differed by a single base pair. Mutant his sequences not identified by probing analysis were amplified using polymerase chain reaction (PCR) and directly sequenced. The combined use of DNA-colony hybridization and direct sequencing offers a precise and rapid means for the molecular characterization of hisD3052 revertants. JF - Environmental and molecular mutagenesis AU - Kupchella, E AU - Cebula, T A AD - Molecular Biology Branch, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 224 EP - 230 VL - 18 IS - 4 SN - 0893-6692, 0893-6692 KW - hisD KW - Oligonucleotide Probes KW - 0 KW - Histidine KW - 4QD397987E KW - Index Medicus KW - Polymerase Chain Reaction KW - Base Sequence KW - Molecular Sequence Data KW - Oligonucleotide Probes -- chemistry KW - Nucleic Acid Hybridization KW - Mutagenicity Tests KW - DNA Mutational Analysis KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72561862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Analysis+of+Salmonella+typhimurium+hisD3052+revertants%3A+the+use+of+oligodeoxyribonucleotide+colony+hybridization%2C+PCR%2C+and+direct+sequencing+in+mutational+analysis.&rft.au=Kupchella%2C+E%3BCebula%2C+T+A&rft.aulast=Kupchella&rft.aufirst=E&rft.date=1991-01-01&rft.volume=18&rft.issue=4&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-23 N1 - Date created - 1992-01-23 N1 - Date revised - 2017-01-13 N1 - Gene symbol - hisD N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biodegradation of 1-nitropyrene. AN - 72487641; 1953305 AB - The metabolism of 14C-labeled 1-nitropyrene in microcosms containing nonsterile estuarine sediments, and in cultures of a Mycobacterium sp. previously isolated from oil-contaminated sediments was investigated. Although mineralization of 1-nitropyrene by pure cultures of the Mycobacterium sp. totaled only 12.3% after 10 days of incubation, over 80% of the ethyl acetate extractable 14C-labeled compounds consisted of 1-nitropyrene metabolites. High pressure liquid chromatographic analysis of 1-nitropyrene degradation products indicated that two major metabolites were formed. They were identified as 1-nitropyrene cis-9,10- and 4,5-dihydrodiols, based on their UV-visible, mass and NMR spectra. Time course studies in microcosms showed that 1-nitropyrene was degraded slowly under aerobic and anaerobic conditions in estuarine sediments. Less than 1% had been converted to 14CO2 after 8 weeks of aerobic incubation. The addition of 1-nitropyrene to anaerobic sediments resulted in no 14CO2 evolution; however, the nitro group of 1-nitropyrene was reduced to form 1-aminopyrene. Although the mineralization of 1-nitropyrene in sediments was slow, the Mycobacterium sp. metabolized 1-nitropyrene in pure culture. This bacterium appears promising for the bioremediation of this ubiquitous pollutant in contaminated waste. JF - Archives of microbiology AU - Heitkamp, M A AU - Freeman, J P AU - Miller, D W AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 223 EP - 230 VL - 156 IS - 3 SN - 0302-8933, 0302-8933 KW - Pyrenes KW - 0 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Mass Spectrometry KW - Kinetics KW - Spectrophotometry, Ultraviolet KW - Biodegradation, Environmental KW - Aerobiosis KW - Chromatography, High Pressure Liquid KW - Anaerobiosis KW - Magnetic Resonance Spectroscopy KW - Environmental Pollution -- prevention & control KW - Soil Microbiology KW - Pyrenes -- metabolism KW - Mycobacterium -- metabolism KW - Water Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72487641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Biodegradation+of+1-nitropyrene.&rft.au=Heitkamp%2C+M+A%3BFreeman%2C+J+P%3BMiller%2C+D+W%3BCerniglia%2C+C+E&rft.aulast=Heitkamp&rft.aufirst=M&rft.date=1991-01-01&rft.volume=156&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A model of chronic neurotoxicity: long-term retention of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) within catecholaminergic neurons. AN - 72484083; 1956587 AB - The mechanism by which 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces lesions in the nigrostriatal dopamine system has been extensively studied. MPTP, a lipophilic molecule, enters the brain rapidly where it is converted to the pyridinium metabolite 1-methyl-4-phenylpyridinium (MPP+), by a two-step reaction that requires the enzyme monoamine oxidase. Following this conversion, which occurs primarily in astrocytes, MPP+ is sequestered within monoaminergic neurons by the energy-requiring monoaminergic transporters. Inside the neuron, MPP+ is thought to act as a mitochondrial toxin, slowly sapping the neuron of its energy-producing potential by blocking the action of NADH dehydrogenase. Much attention has been focused on cell death after MPTP administration, but little attention has been paid to the effects of small subtoxic doses of MPTP (i.e., doses that do not produce overt neuropathologic changes), which might occur during environmental exposure to a nigrostriatal toxin. Low doses of MPTP (as little as 1/25th of a toxic dose) produce long-term (greater than 6 weeks) but reversible changes in catecholamine metabolism. These changes are characterized by a decrease in the products of enzymatic oxidative deamination without a concomitant decrease in the amine concentrations (apparent MAO inhibition). Striatal concentrations of MPP+, which is retained in catecholaminergic terminals for similarly long periods, parallel the metabolic changes. Thus, the long-term storage of the MPTP metabolite, MPP+, correlates with altered catecholamine metabolism. The data on the effects of MPTP have been combined into a working model of how MPP+ exerts its effects following subtoxic or toxic doses. The site of this long-term neuronal storage of MPP+ after exposure to subtoxic doses of MPTP is as yet undetermined, but several studies suggest that monoaminergic vesicles may be the primary site, with mitochondria contributing some storage capacity. This vesicular site could represent a potential brain site for the accumulation of toxins during continual or repeated exposure to low levels of MPTP. Induced release from this site might accelerate the toxic interactions with cellular components such as mitochondria. JF - Neurotoxicology AU - Johannessen, J N AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 285 EP - 302 VL - 12 IS - 2 SN - 0161-813X, 0161-813X KW - Catecholamines KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Animals KW - Humans KW - Corpus Striatum -- metabolism KW - Models, Neurological KW - Time Factors KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- pharmacokinetics KW - Neurons -- metabolism KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Catecholamines -- physiology KW - Neurons -- drug effects KW - MPTP Poisoning KW - 1-Methyl-4-phenylpyridinium -- metabolism KW - Basal Ganglia Diseases -- metabolism KW - Basal Ganglia Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72484083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=A+model+of+chronic+neurotoxicity%3A+long-term+retention+of+the+neurotoxin+1-methyl-4-phenylpyridinium+%28MPP%2B%29+within+catecholaminergic+neurons.&rft.au=Johannessen%2C+J+N&rft.aulast=Johannessen&rft.aufirst=J&rft.date=1991-01-01&rft.volume=12&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-02 N1 - Date created - 1992-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of acrylonitrile by Klebsiella pneumoniae. AN - 72480231; 1953306 AB - A gram-negative rod-shaped bacterium capable of utilizing acrylonitrile as the sole source of nitrogen was isolated from industrial sewage and identified as Klebsiella pneumoniae. The isolate was capable of utilizing aliphatic nitriles containing 1 to 5 carbon atoms or benzonitrile as the sole source of nitrogen and either acetamide or propionamide as the sole source of both carbon and nitrogen. Gas chromatographic and mass spectral analyses of culture filtrates indicated that K. pneumoniae was capable of hydrolyzing 6.15 mmol of acrylonitrile to 5.15 mmol of acrylamide within 24 h. The acrylamide was hydrolyzed to 1.0 mmol of acrylic acid within 72 h. Another metabolite of acrylonitrile metabolism was ammonia, which reached a maximum concentration of 3.69 mM within 48 h. Nitrile hydratase and amidase, the two hydrolytic enzymes responsible for the sequential metabolism of nitrile compounds, were induced by acrylonitrile. The optimum temperature for nitrile hydratase activity was 55 degrees C and that for amidase was 40 degrees C; both enzymes had pH optima of 8.0. JF - Archives of microbiology AU - Nawaz, M S AU - Franklin, W AU - Campbell, W L AU - Heinze, T M AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 231 EP - 238 VL - 156 IS - 3 SN - 0302-8933, 0302-8933 KW - Sewage KW - 0 KW - Amidohydrolases KW - EC 3.5.- KW - Hydro-Lyases KW - EC 4.2.1.- KW - nitrile hydratase KW - Acrylonitrile KW - MP1U0D42PE KW - Index Medicus KW - Amidohydrolases -- metabolism KW - Chromatography, Gas KW - Hydrogen-Ion Concentration KW - Temperature KW - Gas Chromatography-Mass Spectrometry KW - Biodegradation, Environmental KW - Substrate Specificity KW - Hydrolysis KW - Hydro-Lyases -- metabolism KW - Klebsiella pneumoniae -- enzymology KW - Water Pollution -- prevention & control KW - Acrylonitrile -- metabolism KW - Water Microbiology KW - Klebsiella pneumoniae -- metabolism KW - Klebsiella pneumoniae -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72480231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Metabolism+of+acrylonitrile+by+Klebsiella+pneumoniae.&rft.au=Nawaz%2C+M+S%3BFranklin%2C+W%3BCampbell%2C+W+L%3BHeinze%2C+T+M%3BCerniglia%2C+C+E&rft.aulast=Nawaz&rft.aufirst=M&rft.date=1991-01-01&rft.volume=156&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development, use, and availability of a job exposure matrix based on national occupational hazard survey data. AN - 72476582; 1951366 AB - A job exposure matrix has been developed based on potential exposure data collected during the 1972-1974 National Occupational Hazard Survey (NOHS). The survey sample was representative of all U.S. non-agricultural businesses covered under the Occupational Safety and Health Act of 1970 and employing eight or more employees. Potential worker exposure to all chemical, physical, or biological agents was recorded during the field survey if certain minimum guidelines for exposure were met. The job exposure matrix (JEM) itself is a computerized database that assists the user in determining potential chemical or physical exposures in occupational settings. We describe the structure and possible uses of the job exposure matrix. In one example, potential occupational exposures to elemental lead were grouped by industry and occupation. In a second example, the matrix was used to determine exposure classifications in a hypothetical case-control study. Present availability as well as future enhancements of the job exposure matrix are described. JF - American journal of industrial medicine AU - Sieber, W K AU - Sundin, D S AU - Frazier, T M AU - Robinson, C F AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 163 EP - 174 VL - 20 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Occupational Health -- legislation & jurisprudence KW - Data Collection -- methods KW - Humans KW - Case-Control Studies KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure -- statistics & numerical data KW - Occupational Exposure -- classification KW - Databases, Factual KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72476582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Development%2C+use%2C+and+availability+of+a+job+exposure+matrix+based+on+national+occupational+hazard+survey+data.&rft.au=Sieber%2C+W+K%3BSundin%2C+D+S%3BFrazier%2C+T+M%3BRobinson%2C+C+F&rft.aulast=Sieber&rft.aufirst=W&rft.date=1991-01-01&rft.volume=20&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-29 N1 - Date created - 1991-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synthesis and biochemical characteristics of nucleoproteins following a toxic dose of retinoic acid in cycling and differentiating HL-60 cells. AN - 72444668; 1932208 AB - Exposure of HL-60 cells to 2 microM retinoic acid (RA), twice the dose necessary for differentiation, initiated rapid synthesis (2 h) of the nuclear stress proteins (SPs) e.g., 90, 70c, 70x, 22 (Mr x 10(-3)) during the G0 + G1 phase of the cell cycle as observed by polyacrylamide gel electrophoresis (PAGE). Synthesis of SPs was cell cycle correlated and not dependent on time-after-dosing, and all labeling disappeared from these proteins within 48 h of RA exposure. Stress proteins were not elicited with a 1 microM dose or less of retinoic acid. Non-stress nuclear proteins revealed changes in synthesis levels (e.g., actin, lamins, tubulins) which were cell cycle related and temporally associated with dosing. A major non-stress nuclear protein (Mr 120,000) which possessed an affinity for actin in binding assays, was cell cycle related in control cells, and was suppressed in synthesis in cells exposed to 2 microM retinoic acid. Two additional nuclear non-SPs 51 and 55 (Mr x 10(-3)) covalently bound the isotope [3H]retinoic acid, and their incorporation was cell cycle correlated during early periods of RA exposure. Except for the induction of SPs, the autoradiographs of nuclear proteins of RA dosed HL-60 cells, showed more quantitative than qualitative changes. JF - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society AU - Pipkin, J L AU - Hinson, W G AU - Anson, J F AU - Schol, H M AU - Lyn-Cook, L E AU - Burns, E R AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 31 EP - 41 VL - 2 IS - 1 SN - 0954-6642, 0954-6642 KW - Actins KW - 0 KW - Biomarkers KW - Heat-Shock Proteins KW - Neoplasm Proteins KW - Nucleoproteins KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Neoplasm Proteins -- biosynthesis KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Actins -- metabolism KW - Cell Differentiation KW - Heat-Shock Proteins -- biosynthesis KW - Heat-Shock Proteins -- isolation & purification KW - Protein Binding KW - Neoplasm Proteins -- isolation & purification KW - Electrophoresis, Gel, Two-Dimensional KW - Tumor Cells, Cultured -- pathology KW - Cell Cycle KW - Nucleoproteins -- biosynthesis KW - Tretinoin -- toxicity KW - Nucleoproteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72444668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Synthesis+and+biochemical+characteristics+of+nucleoproteins+following+a+toxic+dose+of+retinoic+acid+in+cycling+and+differentiating+HL-60+cells.&rft.au=Pipkin%2C+J+L%3BHinson%2C+W+G%3BAnson%2C+J+F%3BSchol%2C+H+M%3BLyn-Cook%2C+L+E%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Pipkin&rft.aufirst=J&rft.date=1991-01-01&rft.volume=2&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-25 N1 - Date created - 1991-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synthesis and phosphorylation of nuclear matrix proteins following a toxic dose of retinoic acid in cycling and differentiating HL-60 cells. AN - 72443585; 1932206 AB - Exposure of HL-60 cells to 2 microM retinoic acid, twice the dose necessary for differentiation, initiated protein synthesis within 2 h exposure in the nuclear matrix proteins and phosphorylation of a subfraction of these proteins, designated the phenol-soluble nuclear proteins. These processes were examined by fluorography of two-dimensional polyacrylamide gels. Three cell-cycle related stress proteins (22, 70c, 70x Mr x 10(-3)), were seen in the nuclear matrix fraction that were synthesized early and disappeared rapidly following dosing with retinoic acid. In control cells, protein 120 was also cell-cycle related and showed modest synthesis in nuclear matrix and strong phosphorylation in phenol-soluble fraction. Within 5 h after dosing, p120 exhibited alteration in phosphorylation as evidenced by mapping of [32P]-labeled peptides. Two nuclear matrix proteins, p52 and p55, incorporated [3H] retinoic acid rapidly, were cell-cycle-related, and disappeared within 12 h of dosing. Progressive increases in the labeling of the nuclear matrix and phenol-soluble nuclear proteins with increasing retinoic acid exposure was apparent in G2-phase at 96 h time-after-dosing. JF - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society AU - Pipkin, J L AU - Hinson, W G AU - Anson, J F AU - Lyn-Cook, L E AU - Burns, E R AU - Casciano, D A AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 17 EP - 29 VL - 2 IS - 1 SN - 0954-6642, 0954-6642 KW - Antigens, Nuclear KW - 0 KW - Biomarkers KW - Heat-Shock Proteins KW - Neoplasm Proteins KW - Nuclear Proteins KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Neoplasm Proteins -- biosynthesis KW - Tumor Cells, Cultured -- metabolism KW - Peptide Mapping KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Cell Differentiation KW - Heat-Shock Proteins -- biosynthesis KW - Phosphorylation KW - Neoplasm Proteins -- isolation & purification KW - Nuclear Matrix -- metabolism KW - Electrophoresis, Gel, Two-Dimensional KW - Tumor Cells, Cultured -- pathology KW - Cell Cycle KW - Neoplasm Proteins -- metabolism KW - Nuclear Proteins -- isolation & purification KW - Tretinoin -- toxicity KW - Nuclear Proteins -- biosynthesis KW - Nuclear Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72443585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Synthesis+and+phosphorylation+of+nuclear+matrix+proteins+following+a+toxic+dose+of+retinoic+acid+in+cycling+and+differentiating+HL-60+cells.&rft.au=Pipkin%2C+J+L%3BHinson%2C+W+G%3BAnson%2C+J+F%3BLyn-Cook%2C+L+E%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Pipkin&rft.aufirst=J&rft.date=1991-01-01&rft.volume=2&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-25 N1 - Date created - 1991-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Virulence, immunity, and vaccine related to Streptococcus pneumoniae. AN - 72174125; 1930677 AB - The pathogenesis of bacterial infection involves a series of interactions between the virulence determinants of the microorganisms and the immunity of the host. Studies on the molecular structure and immunological properties of pneumococcal virulence factors have provided general knowledge for the chemical basis of immunogenicity and prevention of bacterial infection. Antibody responses to PS and protein antigens can be greatly affected by their physicochemical properties, e.g., molecular size, specific determinants, conformation, etc. Characterization of group 19 pneumolysins and cloning of their ply genes were studied to examine the relationship of ply to virulence. Group 19 pneumococci all contained ply; the disease-isolated types of 19F and 19A appeared to show a higher specific hemolytic activity and yield than the nonpathogenic types, 19B and 19C. Genomic DNA that contained the ply gene from group 19 strains were analyzed by the polymerase chain reaction (PCR). Type 2 oligonucleotide primers recognized and initiated synthesis of an identical 1.5 kb DNA fragment in types 2, 19F, 19A, 19B, and 19C. Their sizes of restriction DNA fragments were also found to be homologous. Thus, group 19 ply genes showed remarkably similar characteristics. A difficult problem in the development of vaccines against bacterial diseases is the poor immune response of young children to purified PSs. The efficacy of pneumococcal vaccine might be improved by supplementation with inactivated pneumolysin in the form of a PS-protein conjugate. JF - Critical reviews in microbiology AU - Lee, C J AU - Banks, S D AU - Li, J P AD - Center for Biologics Evaluation and Research, Bethesda, MD 20892. Y1 - 1991 PY - 1991 DA - 1991 SP - 89 EP - 114 VL - 18 IS - 2 SN - 1040-841X, 1040-841X KW - Antigens, Bacterial KW - 0 KW - Bacterial Vaccines KW - Polysaccharides, Bacterial KW - Neuraminidase KW - EC 3.2.1.18 KW - Index Medicus KW - Virulence KW - Animals KW - Humans KW - Molecular Sequence Data KW - Carbohydrate Sequence KW - Polysaccharides, Bacterial -- toxicity KW - Neuraminidase -- toxicity KW - Antigens, Bacterial -- immunology KW - Immunity KW - Bacterial Vaccines -- immunology KW - Streptococcus pneumoniae -- pathogenicity KW - Streptococcus pneumoniae -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72174125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+microbiology&rft.atitle=Virulence%2C+immunity%2C+and+vaccine+related+to+Streptococcus+pneumoniae.&rft.au=Lee%2C+C+J%3BBanks%2C+S+D%3BLi%2C+J+P&rft.aulast=Lee&rft.aufirst=C&rft.date=1991-01-01&rft.volume=18&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+microbiology&rft.issn=1040841X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-16 N1 - Date created - 1991-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Suppression of human immunoglobulin synthesis by interleukin-4 in tandem with interleukin-2 through large granular lymphocytes. AN - 72169950; 1930692 AB - Recent studies have shown that interleukin (IL)-4 can affect secretion of immunoglobulins (Igs) or activation of cytotoxic cells by IL-2, while other studies have shown that natural killer (NK) cells/large granular lymphocytes (LGLs) can also affect Ig synthesis. Therefore, we examined the effect of IL-4 with and without IL-2 or human NK/LGLs on pokeweed mitogen (PWM)-stimulated production of IgM and IgG. We found that when IL-4 and/or IL-2 were incubated with peripheral blood lymphocytes and PWM for 7 days and an enzyme-linked immunosorbent assay was run to measure Ig synthesis, IL-4 with IL-2 caused a greater suppression of Ig synthesis than either cytokine alone. A further experiment was done to determine the effect IL-4 and IL-2 would have on LGL suppression of Ig synthesis. IL-4 and IL-2 alone and in combination, when added to LGL, caused the LGL to suppress Ig synthesis to a greater extent than alone. We conclude that IL-4 acts on NK/LGLs separately and jointly with IL-2, to suppress Ig synthesis (IgM and IgG). JF - Pathobiology : journal of immunopathology, molecular and cellular biology AU - Bosse, D AU - Ades, E AD - Biological Products Branch, Centers for Disease Control, US Department of Health and Human Services, Atlanta, Ga. Y1 - 1991 PY - 1991 DA - 1991 SP - 391 EP - 395 VL - 59 IS - 6 SN - 1015-2008, 1015-2008 KW - Immunoglobulin G KW - 0 KW - Immunoglobulin M KW - Immunoglobulins KW - Interleukin-2 KW - Pokeweed Mitogens KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Immunoglobulin M -- metabolism KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Immunoglobulin G -- metabolism KW - Drug Synergism KW - Interleukin-2 -- pharmacology KW - Immunoglobulins -- metabolism KW - Interleukin-4 -- pharmacology KW - Killer Cells, Natural -- metabolism KW - Killer Cells, Natural -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72169950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathobiology+%3A+journal+of+immunopathology%2C+molecular+and+cellular+biology&rft.atitle=Suppression+of+human+immunoglobulin+synthesis+by+interleukin-4+in+tandem+with+interleukin-2+through+large+granular+lymphocytes.&rft.au=Bosse%2C+D%3BAdes%2C+E&rft.aulast=Bosse&rft.aufirst=D&rft.date=1991-01-01&rft.volume=59&rft.issue=6&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Pathobiology+%3A+journal+of+immunopathology%2C+molecular+and+cellular+biology&rft.issn=10152008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-26 N1 - Date created - 1991-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Compliance issues and proper animal drug use in aquaculture. AN - 72161250; 1926755 JF - Veterinary and human toxicology AU - Mitchell, G A AD - Office of Surveillance and Compliance, FDA/CVM, Rockville, MD 20857. Y1 - 1991 PY - 1991 DA - 1991 SP - 9 EP - 10 VL - 33 Suppl 1 SN - 0145-6296, 0145-6296 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - United States Environmental Protection Agency KW - Fishes KW - Agriculture -- methods KW - Government Agencies -- standards KW - Fisheries KW - Drug Residues KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72161250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Compliance+issues+and+proper+animal+drug+use+in+aquaculture.&rft.au=Mitchell%2C+G+A&rft.aulast=Mitchell&rft.aufirst=G&rft.date=1991-01-01&rft.volume=33+Suppl+1&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulatory and scientific roles for biodistribution studies in aquatic species. AN - 72159037; 1926750 AB - The advantage of focusing on biliary excretion of drugs and other xenobiotics is emphasized in this discussion of the regulatory and scientific roles for biodistribution studies in aquatic species. The role of the hepatobiliary system in the overall disposition of absorbed chemicals is briefly reviewed. The present survey includes 18 drugs, 6 petroleum hydrocarbons, and 16 different fish species. The fact that aquatic species concentrate most xenobiotics and their metabolites into bile to as much as several orders of magnitude underscores the advantage of using bile rather than tissue to determine whether aquatic species are being exposed to given chemicals. Until these advantages are recognized, analysis of edible muscle tissue remains the method of choice for assessment of human exposure to chemicals. JF - Veterinary and human toxicology AU - Guarino, A M AD - Division of Seafood Research, Food and Drug Administration, Dauphin Island, AL 36525. Y1 - 1991 PY - 1991 DA - 1991 SP - 54 EP - 59 VL - 33 Suppl 1 SN - 0145-6296, 0145-6296 KW - Anti-Bacterial Agents KW - 0 KW - Hydrocarbons KW - Petroleum KW - Index Medicus KW - Animals KW - Muscles -- chemistry KW - Tissue Distribution KW - Bile -- chemistry KW - Hydrocarbons -- analysis KW - Drug Residues -- pharmacokinetics KW - Drug Residues -- analysis KW - Anti-Bacterial Agents -- analysis KW - Hydrocarbons -- pharmacokinetics KW - Fishes -- metabolism KW - Bile -- metabolism KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72159037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Regulatory+and+scientific+roles+for+biodistribution+studies+in+aquatic+species.&rft.au=Guarino%2C+A+M&rft.aulast=Guarino&rft.aufirst=A&rft.date=1991-01-01&rft.volume=33+Suppl+1&rft.issue=&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug abuse prevention evaluation methodology: a bright future. AN - 72130121; 1919958 AB - Drug abuse prevention research findings have been inconsistent. These inconsistencies can be related to several issues including study design and methodology. This article presents consensus recommendations developed to enhance drug abuse prevention evaluation research by a group of prevention researchers and practitioners who met at the National Institute on Drug Abuse in Rockville, Maryland during May 1989. As noted by the number of consensus statements, there was a high level of agreement. After exploring various aspects of evaluating prevention interventions, that agreement was reflected in specific recommendations which are directed to modifying prevention approaches; integrating epidemiologic, etiologic and intervention research methods; and expanding prevention research utilization. JF - Journal of drug education AU - Leukefeld, C G AU - Bukoski, W J AD - U.S. Public Health Service, Rockville, Maryland. Y1 - 1991 PY - 1991 DA - 1991 SP - 191 EP - 201 VL - 21 IS - 3 SN - 0047-2379, 0047-2379 KW - Index Medicus KW - Primary Prevention KW - Public Health -- methods KW - Humans KW - Research Design KW - Program Evaluation -- trends KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72130121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+drug+education&rft.atitle=Drug+abuse+prevention+evaluation+methodology%3A+a+bright+future.&rft.au=Leukefeld%2C+C+G%3BBukoski%2C+W+J&rft.aulast=Leukefeld&rft.aufirst=C&rft.date=1991-01-01&rft.volume=21&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+drug+education&rft.issn=00472379&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-06 N1 - Date created - 1991-11-06 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Confirmation of trace level residues in the food supply. AN - 72116410; 1910522 AB - With the recent proliferation of mass spectrometric methods available for the identification and confirmation of various compounds in different environmental matrices, it is timely to address the criteria desirable in a regulatory sample case. The emphasis of this review is on the experimental process of confirmation at concentration levels in the range of low parts per million (ppm) to parts per trillion (ppt). At such levels, various data manipulations or alternate choices of approaching the analytical problem of confirmation must be employed to ensure an acceptable result. The problems experienced when dealing with nanogram levels in analysis are much more complex than when recording a mass spectrum of an ample supply of a reference standard. This review reflects an interpretation of the developing status of confirmation since there does not yet exist "accepted criteria". JF - Critical reviews in food science and nutrition AU - Cairns, T AU - Siegmund, E G AD - Department of Health and Human Services, Food and Drug Administration Los Angeles, California. Y1 - 1991 PY - 1991 DA - 1991 SP - 397 EP - 402 VL - 30 IS - 4 SN - 1040-8398, 1040-8398 KW - Trace Elements KW - 0 KW - Index Medicus KW - Mass Spectrometry KW - Food Analysis -- standards KW - Drug Residues -- analysis KW - Trace Elements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72116410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+food+science+and+nutrition&rft.atitle=Confirmation+of+trace+level+residues+in+the+food+supply.&rft.au=Cairns%2C+T%3BSiegmund%2C+E+G&rft.aulast=Cairns&rft.aufirst=T&rft.date=1991-01-01&rft.volume=30&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+food+science+and+nutrition&rft.issn=10408398&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anti-nutritive effects of dietary tin. AN - 72110021; 1897407 AB - Tin is usually present in foods at levels of less than 4 micrograms/g. Higher levels may be found in some processed foods due to the addition of tin-based preservatives and stabilizers or to corrosion and leaching of the metal from unlacquered cans or from tin foils used in packaging. Estimates of dietary intake range from about 0.2 to greater than 5 mg Sn/day. Diets including a high proportion of canned vegetables and fish could supply greater than 30 mg Sn/day. Although intakes from dietary sources are generally considered to be harmless, a variety of adverse effects of tin have been reported, including effects on serum and bone alkaline phosphatase, lactic dehydrogenase, heme oxygenase, and 5-aminolevulinic acid dehydratase. Perturbations in glutathione metabolism have been reported, as have adverse effects on metabolism of essential trace minerals such as copper, zinc, and iron. Specific effects on calcium content of bone, serum, and kidney have also been described. Reported effects vary with the chemical form, dose of tin, and route and frequency of administration. Effects of tin in animal systems and on essential trace mineral absorption and excretion in human volunteers are reviewed. A summary of recent investigations on dietary tin-copper interactions and effects of tin on rat hepatocellular antioxidant protection are also presented. JF - Advances in experimental medicine and biology AU - Rader, J I AD - Division of Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 509 EP - 524 VL - 289 SN - 0065-2598, 0065-2598 KW - Manganese KW - 42Z2K6ZL8P KW - Tin KW - 7440-31-5 KW - Copper KW - 789U1901C5 KW - Iron KW - E1UOL152H7 KW - Zinc KW - J41CSQ7QDS KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Eating -- drug effects KW - Weight Gain -- drug effects KW - Animals KW - Duodenum -- chemistry KW - Iron -- analysis KW - Manganese -- analysis KW - Dose-Response Relationship, Drug KW - Calcium -- analysis KW - Food Handling KW - Kidney -- chemistry KW - Liver -- chemistry KW - Food Preservation KW - Rats KW - Zinc -- analysis KW - Femur -- chemistry KW - Copper -- analysis KW - Male KW - Tin -- adverse effects KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72110021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Anti-nutritive+effects+of+dietary+tin.&rft.au=Rader%2C+J+I&rft.aulast=Rader&rft.aufirst=J&rft.date=1991-01-01&rft.volume=289&rft.issue=&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-24 N1 - Date created - 1991-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Residue trypsin inhibitor: data needs for risk assessment. AN - 72106329; 1897396 AB - Trypsin inhibitor (TI) occurs naturally in many foods from plants, notably soybean protein products. Heat treatment inactivates TI and improves nutritional quality, but residual TI activity of 5 to 20% remains after typical commercial treatments. Chronic feeding of TI or products that contain TI can inhibit trypsin and chymotrypsin, stimulate their secretion, cause hypertrophy and hyperplasia of the pancreas, and lead to adenomas and carcinomas of the exocrine pancreas. In the rat, TI promotes pancreatic carcinogenesis initiated by azaserine. Data needed for possible risk assessment on TI would include 2-year bioassays from animals treated with TI and fed diets carefully controlled for type and amount of fat (which also promotes pancreatic carcinogenesis). The effects of TI on protein nutrition would have to be considered when identifying the maximum tolerated dose. Major reductions in human dietary TI exposure may not be feasible because of the multiple sources of TI, the substantial promotion by other factors such as fat, and the adverse effects of excessive heat on food products. For risk assessment of TI in a particular food, other promotors and the feasibility of decreasing TI intake must be considered. JF - Advances in experimental medicine and biology AU - Hathcock, J N AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 273 EP - 279 VL - 289 SN - 0065-2598, 0065-2598 KW - Trypsin Inhibitors KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Pancreas -- drug effects KW - Trypsin Inhibitors -- toxicity KW - Soybeans -- toxicity KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72106329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Residue+trypsin+inhibitor%3A+data+needs+for+risk+assessment.&rft.au=Hathcock%2C+J+N&rft.aulast=Hathcock&rft.aufirst=J&rft.date=1991-01-01&rft.volume=289&rft.issue=&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-24 N1 - Date created - 1991-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The use of uninduced rat liver S-9 to supplement BALB/3T3 cells in the in vitro transformation assay. AN - 72088947; 1889371 AB - Because of limited inherent capacity to metabolize chemicals to their reactive form, the BALB/3T3 transformation assay using clone A31-1-1 cells requires metabolic supplementation with rodent liver homogenate preparations (S-9). Activation by S-9 is limited, however, by its cytotoxicity to the cells, thus necessitating a reduction in treatment time from the usual 24-72 to 1-4 hr. With cyclophosphamide (CP) as a test chemical, we were able to increase the treatment time to 24 hr by using lower concentrations of cofactors and S-9 prepared from the livers of untreated rats. Statistically significant increases in transformed foci were induced in cultures treated with 50 or 100 micrograms CP/ml in the presence of 100 or 200 micrograms of uninduced rat liver S-9/ml and 76 or 380 micrograms each of NADH, NADP, NADPH, and glucose-6-phosphate per ml of incubation medium. JF - Drug and chemical toxicology AU - Sheu, C J AU - Lee, J K AU - Rodriguez, I AU - Randolph, S C AD - Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1991 PY - 1991 DA - 1991 SP - 113 EP - 126 VL - 14 IS - 1-2 SN - 0148-0545, 0148-0545 KW - Carcinogens KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cells, Cultured KW - Biotransformation KW - Cyclophosphamide -- metabolism KW - Cyclophosphamide -- toxicity KW - Male KW - Carcinogens -- metabolism KW - Microsomes, Liver -- metabolism KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72088947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=The+use+of+uninduced+rat+liver+S-9+to+supplement+BALB%2F3T3+cells+in+the+in+vitro+transformation+assay.&rft.au=Sheu%2C+C+J%3BLee%2C+J+K%3BRodriguez%2C+I%3BRandolph%2C+S+C&rft.aulast=Sheu&rft.aufirst=C&rft.date=1991-01-01&rft.volume=14&rft.issue=1-2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-15 N1 - Date created - 1991-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hydroxylation and deglycosylation of 2'-deoxyguanosine in the presence of magnesium and nickel. AN - 72070070; 1884431 AB - Nickel (Ni), a carcinogenic and genotoxic metal, has been shown to enhance deglycosylation and hydroxylation of 2'-deoxyguanosine (dG) that has been caused by ascorbic acid and H2O2. There is evidence that Mg is a competitive antagonist of the toxicological effects of Ni. A factorial design was used to examine the interactive influence of Mg and Ni on the deglycosylation and hydroxylation of dG under a range of pH conditions in which ascorbate (Ascb) and H2O2 were added. Formation of guanine (Gu) (deglycosylation) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG) (hydroxylation) appeared in large amounts in samples in which both H2O2 and Ascb were present. The largest amounts of Gu appeared where both Ni or magnesium (Mg) were present. When Mg alone was present, the amounts of Gu was intermediate between these two. Slightly less 8-OH-dG was formed where only Mg was present. The reaction mixtures were more sensitive to the pH than to the respective presence or absence of metals. At slightly acid or neutral pH (6.2-7.0) large amounts of both Gu and 8-OH-dG were formed. Gu formation decreased dramatically between pH 7.0 and 7.2. There was no 8-OH-dG formed at pH 7.8 and only small amounts at pH 7.6. The formation of 8-OH-dG was generally less where Mg was present. When Ni was absent, 8-OH-dG formation was greater in the pH 6.8 mixtures. The formation of Gu and 8-OH-dG from 2'-deoxyguanosine are directly a function of pH. Slight changes in pH greatly effected the formation of these biomarkers of oxidatively damaged DNA. Additional research is needed to determine if this is a cause or effect, i.e. does pH enhance toxicity conditions, thus permitting formation of 8-OH-dG, or does pH permit the reaction to proceed. JF - Chemico-biological interactions AU - Littlefield, N A AU - Fullerton, F R AU - Poirier, L A AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 217 EP - 228 VL - 79 IS - 2 SN - 0009-2797, 0009-2797 KW - Nickel KW - 7OV03QG267 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Deoxyguanosine KW - G9481N71RO KW - Magnesium KW - I38ZP9992A KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Hydrogen Peroxide -- toxicity KW - Glycosylation -- drug effects KW - Biotransformation KW - Hydrogen-Ion Concentration KW - Hydroxylation -- drug effects KW - Ascorbic Acid -- toxicity KW - Deoxyguanosine -- metabolism KW - Deoxyguanosine -- pharmacokinetics KW - Magnesium -- toxicity KW - Nickel -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72070070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Hydroxylation+and+deglycosylation+of+2%27-deoxyguanosine+in+the+presence+of+magnesium+and+nickel.&rft.au=Littlefield%2C+N+A%3BFullerton%2C+F+R%3BPoirier%2C+L+A&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1991-01-01&rft.volume=79&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-09 N1 - Date created - 1991-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational sentinel health events: an up-dated list for physician recognition and public health surveillance. AN - 72067849; 1882855 AB - An occupational sentinel health event (SHE[O]) is a disease, disability, or untimely death, which is occupationally related and whose occurrence may: 1) provide the impetus for epidemiologic or industrial hygiene studies; or 2) serve as a warning signal that materials substitution, engineering control, personal protection, or medical care may be required. Following survey of scientific literature, a list of 50 disease conditions linked to the workplace was presented in 1983; these were codable within the framework of the International Classification of Diseases system (ICD-9). Three criteria were used for inclusion: documentation of associated agent(s), of involved industries, and of involved occupations. The up-dated list contains 64 diseases or conditions and a bibliography of literature citations. The list is useful for the practicing physician in occupational disease recognition, for occupational morbidity and mortality surveillance, and as a periodically up-dated database of occupationally related diseases. JF - American journal of industrial medicine AU - Mullan, R J AU - Murthy, L I AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, OH 45226. Y1 - 1991 PY - 1991 DA - 1991 SP - 775 EP - 799 VL - 19 IS - 6 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Occupational Health KW - Information Systems KW - Quality of Health Care KW - Humans KW - United States -- epidemiology KW - Morbidity KW - Population Surveillance KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72067849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Occupational+sentinel+health+events%3A+an+up-dated+list+for+physician+recognition+and+public+health+surveillance.&rft.au=Mullan%2C+R+J%3BMurthy%2C+L+I&rft.aulast=Mullan&rft.aufirst=R&rft.date=1991-01-01&rft.volume=19&rft.issue=6&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-01 N1 - Date created - 1991-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Flow cytometric evaluation of cell-cycle progression in ethyl methanesulfonate and methyl methanesulfonate-exposed P3 cells: relationship to the induction of sister-chromatid exchanges and cellular toxicity. AN - 72058412; 1879406 AB - In order to determine the relationships among the reduction in relative cloning efficiency (RCE), sister-chromatid exchange (SCE) formation, and interference with progression through the cell-cycle, human teratocarcinoma-derived (P3) cells were exposed to either ethyl methanesulfonate or to methyl methanesulfonate. The relationship between SCE and toxicity was quantified, the progression through the cell-cycle was evaluated with flow cytometric methods, and the effects of these chemicals on cell growth and average generation time (AGT) were determined. A strong correlation existed between RCE and SCE (r = -0.978, p less than .001) which was accompanied by an inhibition of growth as evidenced by a significant (p less than .0001) negative linear effect of concentration on the relative cell count from 24 to 72 hours after exposure and by a concentration-dependent increase (p less than .0001) in the AGT. Delays in the transit through S-phase were evident 4 hours after exposure to toxic concentrations of either carcinogen and by 8 to 12 hours post-exposure at the lower concentrations. Increases in the percentage of nuclei in G2 + M, indicative of G2 arrest, occurred from 12 to 24 hours after exposure. One interpretation of these results is that those effects of EMS and MMS exposure which result in S-phase delay and G2 arrest may be those elements common to the induction of SCE and cellular toxicity. JF - Environmental and molecular mutagenesis AU - Morris, S M AU - Domon, O E AU - McGarrity, L J AU - Kodell, R L AU - Casciano, D A AD - Division of Genetic Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1991 PY - 1991 DA - 1991 SP - 139 EP - 149 VL - 18 IS - 2 SN - 0893-6692, 0893-6692 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Index Medicus KW - Tumor Cells, Cultured KW - Dose-Response Relationship, Drug KW - Humans KW - In Vitro Techniques KW - Flow Cytometry KW - Time Factors KW - Teratoma KW - Methyl Methanesulfonate -- toxicity KW - Sister Chromatid Exchange KW - Ethyl Methanesulfonate -- toxicity KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72058412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Flow+cytometric+evaluation+of+cell-cycle+progression+in+ethyl+methanesulfonate+and+methyl+methanesulfonate-exposed+P3+cells%3A+relationship+to+the+induction+of+sister-chromatid+exchanges+and+cellular+toxicity.&rft.au=Morris%2C+S+M%3BDomon%2C+O+E%3BMcGarrity%2C+L+J%3BKodell%2C+R+L%3BCasciano%2C+D+A&rft.aulast=Morris&rft.aufirst=S&rft.date=1991-01-01&rft.volume=18&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-01 N1 - Date created - 1991-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Mass Media and Health: Opportunities for Improving the Nation's Health. A Report to the Office of Disease Prevention and Health Promotion and Office for Substance Abuse Prevention. Monograph Series. AN - 62908689; ED346886 AB - Several interested organizations and agencies completed an exploration of the complexities and challenges affecting the communication of health information through the mass media. The goal of this effort was to create a shared agenda for increasing cooperation between mass media and public health professionals in addressing the issues, problems, and challenges of communicating health information to the public. The process included convening a group of experts to identify the issues; commissioning a series of papers to explore the issues; and bringing together public health and mass media representatives to identify barriers to collaboration and opportunities for working together to improve the quality and quantity of health coverage through the media. The objectives of this project included: (1) increasing understanding of the influences of mass communications on health issues and problems; (2) exploring shared responsibilities among media and public health professionals; (3) designing strategies for influencing policymakers and gatekeepers in the mass media and public health fields; and (4) setting priorities within both sectors for future discussion and exploration. This report summarizes the issues explored and presents a series of strategies for increasing cooperation between mass media and the public health community. Recommendations are presented for marketing communications, news, entertainment, the public health response to media interests and needs, the media response to public health needs, and policies and regulations affecting health communications. Appended materials include lists of program sponsors and contributors to the program as well as a list of eight papers commissioned for the project. (BBM) Y1 - 1991 PY - 1991 DA - 1991 SP - 68 KW - Health Information KW - ERIC, Resources in Education (RIE) KW - Substance Abuse KW - Information Dissemination KW - Advertising KW - Health Education KW - News Reporting KW - Mass Media Role KW - Disease Control KW - Mass Media Effects KW - Public Health KW - Broadcast Journalism KW - Programing (Broadcast) KW - Federal Regulation KW - Change Strategies KW - Change Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62908689?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Policy Report of the Physician Consortium on Substance Abuse Education. AN - 62829582; ED350944 AB - This report contains the recommendations of the Physician Consortium for significantly improving medical education and training to enhance the physician's role in early identification, treatment, and prevention of substance abuse. In addition, the consortium subcommittees report on their examination of substance abuse treatment needs of ethnic and racial minority groups and on the unique training needs that are especially germane to the care of adolescents and children. Recommendations address the need for changes in undergraduate medical education, graduate medical education, and continuing medical education; they also focus special attention on the concerns of adolescents and children and the multicultural issues in substance abuse education and training of physicians. The report concludes with background information on the problems of substance abuse in general and on certain specific substances--cocaine, marijuana, alcohol and tobacco products--in particular. Contains 32 references. (GLR) AU - Lewis, David C. AU - Faggett, Walter L. Y1 - 1991 PY - 1991 DA - 1991 SP - 38 VL - HRSA-P-DM-91-3 KW - Primary Prevention KW - ERIC, Resources in Education (RIE) KW - Policymakers KW - Health Programs KW - Substance Abuse KW - Undergraduate Study KW - Higher Education KW - National Surveys KW - Educational Needs KW - Children KW - Medical Education KW - Health Promotion KW - Alcohol Abuse KW - Minority Groups KW - Ethnic Groups KW - Continuing Education KW - Professional Education KW - Graduate Medical Education KW - Physicians KW - Adolescents KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62829582?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Abuse, Neglect, and the HIV-Infected Child AN - 61633861; 199101178 AB - The effects of HIV (human immunodeficiency virus) on child abuse prevention are considered on two levels: indirect, ie, the demands made on medical & social services due to the disease may lead to decreasing resources for child abuse prevention, & direct, ie, the actual abuse & neglect of HIV-infected children. The overall prevalence of the disease is estimated using 1986 data, noting the lack of accurate data on infection rates in infants & children. Four major HIV-related issues that have direct child abuse or neglect implications are discussed: ostracism & school attendance, hospitalization of the infected child, non-hospital care/foster placement of the infected child, & HIV-antibody screening of the sexually abused child. 9 Tables, 2 Figures, 2 References. S. Dilts JF - Child Abuse and Neglect AU - Jason, Janine M AD - Public Health Service Centers Disease Control, 1600 Clifton Rd Atlanta GA 30333 Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 79 EP - 88 VL - 15 SN - 0145-2134, 0145-2134 KW - child abuse prevention, human immunodeficiency virus-infected children KW - Prevention KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Children KW - Child Abuse KW - article KW - 6143: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61633861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+and+Neglect&rft.atitle=Abuse%2C+Neglect%2C+and+the+HIV-Infected+Child&rft.au=Jason%2C+Janine+M&rft.aulast=Jason&rft.aufirst=Janine&rft.date=1991-01-01&rft.volume=15&rft.issue=&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+and+Neglect&rft.issn=01452134&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child Abuse; Prevention; Acquired Immune Deficiency Syndrome; Children; Intervention ER - TY - BOOK T1 - Locating resources for Healthy People 2000 health promotion projects AN - 59591749; 1992-0406015 AB - Sources of funds and other support for health promotion projects available through private organizations and public agencies. JF - Supt Docs, 1991. 46+10 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - 46+10 PB - Supt Docs SN - 0160359287 KW - Government loans and grants -- United States KW - Community funds -- United States KW - Public health -- United States KW - Medicine, Preventive -- United States KW - Public health education -- United States KW - Philanthropy -- United States KW - United States -- Health policy KW - Community health services -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59591749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=46%2B10&rft.isbn=0160359287&rft.btitle=Locating+resources+for+Healthy+People+2000+health+promotion+projects&rft.title=Locating+resources+for+Healthy+People+2000+health+promotion+projects&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Supt Docs (ISBN 0-16-035928-7) pa U.S. $3.25; elsewhere $4.06 N1 - Document feature - bibl(s), il(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Health status of minorities and low-income groups AN - 59583075; 1992-0204512 AB - Documents disparity between the general and the disadvantaged population. Prevention, mental, dental, and reproductive health, chronic and acute diseases, injuries, HIV/AIDS, old age, utilization of services, and insurance and expenditures. JF - Supt Docs, 1991. iii+376 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - iii+376 PB - Supt Docs SN - 016030573X KW - Minorities -- Health -- Statistics KW - United States -- Social conditions KW - Poor -- Health -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59583075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=iii%2B376&rft.isbn=016030573X&rft.btitle=Health+status+of+minorities+and+low-income+groups&rft.title=Health+status+of+minorities+and+low-income+groups&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Supt Docs (ISBN 0-16-030573-X) pa U.S. $18; elsewhere $22.50 N1 - Document feature - table(s), chart(s) N1 - SuppNotes - 3d ed N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Healthy children 2000: national health promotion and disease prevention objectives related to mothers, infants, children, adolescents, and youth T2 - Dept. of Health and Human Services. DHHS pubn. no. HRSA-M-CH 91-2 AN - 59579151; 1992-0200994 AB - Adapted from "Healthy people 2000," indexed in the 1991 PAIS International in Print. JF - Washington, DC 20201, 1991. 244 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 244 PB - Washington, DC 20201 KW - Maternal and infant welfare -- United States KW - Child health -- United States KW - Public health -- United States KW - Medicine, Preventive -- United States KW - Health planning -- United States KW - United States -- Health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59579151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=Adrian&rft.date=2015-06-24&rft.volume=401&rft.issue=60&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Aviation+Daily&rft.issn=01934597&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20201 pa N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Nursing home reform and the mentally ill T2 - Nat. Med. Expenditure Survey AHCPR pubn. no. 91-0010 AN - 59575189; 1991-0913688 AB - Implications of the Medicaid reforms of the 1987 Omnibus Budget Reconciliation Act; estimates the number of mentally ill residents who might be displaced by the review and screening process. Also printed in Health Affairs 9:47-60 Winter '90. JF - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, 1991. 47-60 pp. AU - Freiman, Marc P Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 14 EP - 60 PB - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - Medicaid program -- United States KW - Mentally ill -- Care and treatment KW - Mentally ill -- United States KW - Nursing homes -- United States KW - United States -- Social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59575189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Freiman%2C+Marc+P&rft.aulast=Freiman&rft.aufirst=Marc&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=Nursing+home+reform+and+the+mentally+ill&rft.title=Nursing+home+reform+and+the+mentally+ill&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 N1 - Document feature - table(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Injury mortality atlas of the United States, 1979-1987 AN - 59574666; 1991-1510077 AB - Organized by type of injury, including homicide and suicide, state, and county. Prepared by the Centers for Disease Control and other agencies. JF - Atlanta, GA 30333, 1991. ii+141 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - ii+141 PB - Atlanta, GA 30333 KW - Personal injuries -- United States -- Statistics KW - Homicide -- United States -- Statistics KW - Suicide -- United States -- Statistics KW - United States -- Demographics KW - Accidents -- United States -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59574666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=ii%2B141&rft.isbn=&rft.btitle=Injury+mortality+atlas+of+the+United+States%2C+1979-1987&rft.title=Injury+mortality+atlas+of+the+United+States%2C+1979-1987&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Atlanta, GA 30333 (22x28 cm) spiral bdg N1 - Document feature - bibl(s), table(s), chart(s), map(s) N1 - SuppNotes - leaves N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Trends in Indian health, 1991 AN - 59573206; 1992-0110828 AB - Structure of the IHS and health status of American Indians and Alaska natives. Includes birth, mortality, patient care, and community health statistics. JF - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane Rockville, MD 20857, 1991. vi+93 pp. Y1 - 1991///0, PY - 1991 DA - 0, 1991 EP - vi+93 PB - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane Rockville, MD 20857 KW - Alaska -- Native races -- Health KW - Indians -- Health -- Statistics KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59573206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=vi%2B93&rft.isbn=&rft.btitle=Trends+in+Indian+health%2C+1991&rft.title=Trends+in+Indian+health%2C+1991&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane Rockville, MD 20857 pa N1 - Document feature - table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Statistical evaluation and time series analysis of microseismicity, mining, and rock bursts in a hard-rock mine AN - 51273669; 2008-042178 AB - Quantifying relationships between microseismicity and mining geometry and stress. JF - Report of Investigations - United States. Bureau of Mines AU - Riefenberg, J Y1 - 1991 PY - 1991 DA - 1991 SP - 15 PB - U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Washington, D.C. SN - 1066-5552, 1066-5552 KW - deep mining KW - rock bursts KW - statistical analysis KW - microseisms KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51273669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Riefenberg%2C+J&rft.aulast=Riefenberg&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Statistical+evaluation+and+time+series+analysis+of+microseismicity%2C+mining%2C+and+rock+bursts+in+a+hard-rock+mine&rft.title=Statistical+evaluation+and+time+series+analysis+of+microseismicity%2C+mining%2C+and+rock+bursts+in+a+hard-rock+mine&rft.issn=10665552&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from the AESIS Database supplied under licence from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2008-01-01 N1 - Number of references - 43 N1 - PubXState - D.C. N1 - Document feature - illus. incl. 4 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - deep mining; microseisms; rock bursts; statistical analysis ER - TY - JOUR T1 - Technological developments with the FDA adverse drug reaction file system AN - 16748986; 3520643 AB - A review of the Food and Drug Administration (FDA) Adverse Drug Reaction (ADR) file system. This paper describes the current operations for maintaining the on-line computerized data entry, storage and retrieval programs, and the microfilm retrieval system. Other technology developments discussed include data diskette exchange and laser disc storage and retrieval. JF - Drug Information Journal AU - Gelberg, A AU - Armstrong, G D AU - Dreis, M W AU - Anello, C AD - HFD-737, Cent. Drug Eval. and Res., FDA, 5600 Fishers La., Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 19 EP - 28 VL - 25 IS - 1 SN - 0092-8615, 0092-8615 KW - FDA KW - Toxicology Abstracts KW - side effects KW - data collections KW - pharmaceuticals KW - X 24230:Legislation & recommended standards KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16748986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Technological+developments+with+the+FDA+adverse+drug+reaction+file+system&rft.au=Gelberg%2C+A%3BArmstrong%2C+G+D%3BDreis%2C+M+W%3BAnello%2C+C&rft.aulast=Gelberg&rft.aufirst=A&rft.date=1991-01-01&rft.volume=25&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - pharmaceuticals; side effects; data collections ER - TY - JOUR T1 - Access, science, and regulation AN - 16742621; 3520644 AB - There is a potential tension between the desirable goals of assuring early availability of promising agents for treatment of serious illnesses without adequate therapy and developing such agents in a rigorous way that will yield scientifically valid answers about their safety and effectiveness. Because the two goals are linked to fundamental principles and values, it is possible for people who feel strongly about one of them to ignore the importance of the other. But it is neither necessary nor desirable to choose one goal exclusively; Early access is reasonable on both ethical and medical grounds and can be provided, with care and planning, without degrading the quality of evidence we develop to support new agents. A clear picture of the effectiveness and safety of a drug, and information on how best to use it is most critical, not to academics and regulators, but to the patients whose lives and health may depend on the drug, and obtaining this information does not require that access be denied until it is all in hand. JF - Drug Information Journal AU - Temple, R J AD - Off. Drug Eval. 1, FDA, HFD 100, 5600 Fishers La., Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1 EP - 11 VL - 25 IS - 1 SN - 0092-8615, 0092-8615 KW - Toxicology Abstracts KW - safety KW - research programs KW - pharmaceuticals KW - evaluation KW - X 24230:Legislation & recommended standards KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16742621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Access%2C+science%2C+and+regulation&rft.au=Temple%2C+R+J&rft.aulast=Temple&rft.aufirst=R&rft.date=1991-01-01&rft.volume=25&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - pharmaceuticals; safety; evaluation; research programs ER - TY - BOOK T1 - Natural toxins [in seafoods] AN - 16735294; 3718519 AB - Natural toxins in seafoods present many challenges, many of which have yet to be satisfactorily addressed. The development and implementation of appropriate measures is and will remain expensive. But the payoff is great, and more than justifies the investment. Seafood can be a wholesome, enjoyable, and affordable source of nutrition and will find an eager marker if quality and safety are assured. JF - VAN ROSTRAND REINHOLD, NEW YORK (USA). pp. 301-330. 1991. AU - Hall, S Y1 - 1991 PY - 1991 DA - 1991 SP - 30 EP - 330 PB - VAN ROSTRAND REINHOLD, NEW YORK (USA) SN - 0442233469 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - biological poisons KW - seafood KW - quality control KW - food poisoning KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16735294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hall%2C+S&rft.aulast=Hall&rft.aufirst=S&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=301&rft.isbn=0442233469&rft.btitle=Natural+toxins&rft.title=Natural+toxins&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Includes bibliogr: 117 ref. N1 - Last updated - 2014-05-06 ER - TY - JOUR T1 - The raw oyster consumer -- A risk taker? Use of the behavioral risk factor surveillance system AN - 16734738; 3518690 AB - 1988 Behavioral Risk Factor Surveillance System in Florida was used to determine the prevalence of consumption of raw oysters, a vehicle implicated in the transmission of several pathogens. One-third of survey respondents reported ever eating raw oysters. The prevalence was higher for persons 18-49 years old and for males, and, when controlled for age and sex, for persons who reported being cigarette smokers or acute or chronic alcohol drinkers, and driving while intoxicated. JF - Epidemiology AU - Klontz, K C AU - Desenclos, JCA AU - Wolfe, LE AU - Hoecherl, SA AU - Roberts, C AU - Gunn, R A AD - Clin. Nutr. Br., Cent. Food Saf. and Appl. Nutr., FDA, Washington, DC, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 437 EP - 440 VL - 2 IS - 6 SN - 1044-3983, 1044-3983 KW - raw oysters KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine KW - pathogenic bacteria KW - seafood KW - hazard assessment KW - human food KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16734738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology&rft.atitle=The+raw+oyster+consumer+--+A+risk+taker%3F+Use+of+the+behavioral+risk+factor+surveillance+system&rft.au=Klontz%2C+K+C%3BDesenclos%2C+JCA%3BWolfe%2C+LE%3BHoecherl%2C+SA%3BRoberts%2C+C%3BGunn%2C+R+A&rft.aulast=Klontz&rft.aufirst=K&rft.date=1991-01-01&rft.volume=2&rft.issue=6&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Epidemiology&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - pathogenic bacteria; seafood; human food; hazard assessment; public health; Marine ER - TY - BOOK T1 - Non-indigenous bacterial pathogens AN - 16733613; 3718562 AB - An account is given of bacterial pathogens which, although often present in seafood, are not common to the marine environment. These pathogens are rather the result of direct fecal transmission from human or animal reservoir or a result of poor general sanitation. The first category of risk includes species of fish eaten raw (sushi) and other aquatic food animals such as molluscs. The second category results from insanitary practices during fish product handling. The following species are discussed: Clostridium botulinum, Listeria monocytogenes, Staphylococcus aureus, Salmonella and Shigella. It is concluded that food sanitation and quality control measures that consider the safety of seafood from harvest to consumption must be developed in the future to ensure a continued high level of safety. JF - VAN ROSTRAND REINHOLD, NEW YORK (USA). pp. 267-284. 1991. AU - Kvenberg, JE Y1 - 1991 PY - 1991 DA - 1991 SP - 18 EP - 284 PB - VAN ROSTRAND REINHOLD, NEW YORK (USA) SN - 0442233469 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Listeria monocytogenes KW - pathogenic bacteria KW - microbial contamination KW - seafood KW - quality control KW - Shigella KW - Clostridium botulinum KW - Staphylococcus aureus KW - Salmonella KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16733613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kvenberg%2C+JE&rft.aulast=Kvenberg&rft.aufirst=JE&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=267&rft.isbn=0442233469&rft.btitle=Non-indigenous+bacterial+pathogens&rft.title=Non-indigenous+bacterial+pathogens&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 ER - TY - JOUR T1 - Evaluating posture behavior during seated tasks AN - 16726548; 3516390 AB - A method was developed to evaluate posture behavior of the trunk, neck, eye, and upper extremity in three-dimensional space during the performance of static, seated tasks. Body postures were measured using an ultrasonic measurement system to determine the Cartesian coordinates of joints and the angles between adjacent limbs. Posture preferences for a variety of visual and manual tasks were then determined. Pilot studies using three subjects performing visual and right-handed tasks showed that the postures were affected by target location, body size, and target size. These experiments suggest that the preferred horizontal location of visual targets is within 10 degree of the sagittal plane of the head. The preferred vertical location of visual targets is 10 degree to 35 degree below the seated eye height. For manual reaches, the target-to-shoulder distance should be at least one-third the length of the upper extremity to avoid extreme elbow flexion. In addition, the seat pan should swivel and should allow a person to move fore and aft in order to adjust to a comfortable work posture. JF - International Journal of Industrial Ergonomics AU - Hsiao, H AU - Keyserling, WM AD - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 313 EP - 334 VL - 8 IS - 4 SN - 0169-8141, 0169-8141 KW - posture KW - Health & Safety Science Abstracts KW - behavior KW - measuring methods KW - ergonomics KW - ultrasonics KW - H SI0.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16726548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Evaluating+posture+behavior+during+seated+tasks&rft.au=Hsiao%2C+H%3BKeyserling%2C+WM&rft.aulast=Hsiao&rft.aufirst=H&rft.date=1991-01-01&rft.volume=8&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ergonomics; behavior; ultrasonics; measuring methods ER - TY - JOUR T1 - A longitudinal study of pulmonary function in fire fighters AN - 16718753; 3510120 AB - Pulmonary function changes among fire fighters were evaluated by re-examining 632 Baltimore city fire fighters six to ten years after a baseline examination. Spirometry was used to determine forced expiratory volume in 1 second (FEV sub(1)). Information about exposures was obtained by questionnaire and by combining data from fire department records regarding the number of fires fought by fire fighting units with individual work histories. Men who never wore a mask while extinguishing fires experienced a 1.7 times greater rate of FEV sub(1) decline than mask wearers. Men with ammonia exposure experienced a rate of decline 1.7 times greater than non-exposed men. Neither length of time spent in exposed jobs nor number of responses were associated with the rate of decline. Active fire fighters experienced a rate of decline 2.5 times greater than those who had retired or resigned. Some effects differed between men who were able to perform repeatable pulmonary function tests and those who were not. JF - American Journal of Industrial Medicine AU - Tepper, A AU - Comstock, G W AU - Levine, M AD - NIOSH, R-18, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 307 EP - 316 VL - 20 IS - 3 SN - 0271-3586, 0271-3586 KW - firefighter services KW - occupational health KW - occupational hazards KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - respiratory system KW - ammonia KW - protective clothing KW - fires KW - lung KW - respiratory function KW - X 24240:Miscellaneous KW - H SE8.28:FIREFIGHTER SERVICES AND SAFETY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16718753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+longitudinal+study+of+pulmonary+function+in+fire+fighters&rft.au=Tepper%2C+A%3BComstock%2C+G+W%3BLevine%2C+M&rft.aulast=Tepper&rft.aufirst=A&rft.date=1991-01-01&rft.volume=20&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ammonia; occupational health; respiratory system; protective clothing; lung; respiratory function; fires; occupational hazards ER - TY - JOUR T1 - The insulin A and B chains contain sufficient structural information to form the native molecule. AN - 16701710; 2982284 AB - Refolding studies show that native insulin can be reformed from A and B chains only. This suggests that the A and B chains contain the necessary structural information and that the C peptide is not required for this process. JF - Trends in Biochemical Sciences AU - Wang, Chih-Chen AU - Tsou, Chen-Lu AD - Div. Biochem. and Biophys., Cent. Biol., Eval. and Res., FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 279 EP - 281 VL - 16 IS - 8 SN - 0968-0004, 0968-0004 KW - A chains KW - B chains KW - C peptide KW - folding KW - insulin KW - requirements KW - reviews KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16701710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biochemical+Sciences&rft.atitle=The+insulin+A+and+B+chains+contain+sufficient+structural+information+to+form+the+native+molecule.&rft.au=Wang%2C+Chih-Chen%3BTsou%2C+Chen-Lu&rft.aulast=Wang&rft.aufirst=Chih-Chen&rft.date=1991-01-01&rft.volume=16&rft.issue=8&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biochemical+Sciences&rft.issn=09680004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 ER - TY - CONF T1 - Food and Drug Administration and National Marine Fisheries Service joint seafood initiative: Status. AN - 16662362; 3018710 AB - Seafood safety is regulated at the Federal level primarily by the U.S. Food and Drug Administration (FDA) which operates a comprehensive, mandatory program under the authorities of the Federal Food Drug and Cosmetic Act and the Public Health Service Act. In addition to this mandatory program, the states operate mandatory seafood regulatory programs designed to meet their regional needs. The National Marine Fisheries Service (NMFS) operates a voluntary, fee-for-service inspection program under the authorities of the Agricultural Marketing Act of 1946 and the Fish and Wildlife Act of 1956. A Memorandum of Understanding (MOU) exists between FDA and NMFS relating to this program. Under that MOU, NMFS ensures that industry participant's operations and products meet the requirements of the FD & C Act, as well as NMFS quality and identity requirements. In 1991 FDA and NOAA/NMFS began the design of a new, jointly operated inspection program and enlisted the cooperation of the seafood industry to the extent that industry trade groups and individuals would participate. This joint program is based on the principles of the Hazard Analysis Critical Control Point system of food inspection. This system requires the industry to develop and maintain records of control points in their process that have been determined critical for the control of product safety, plant/food hygiene, and economic fraud hazards associated with the particular product. Industry and government then become partners in the business of food inspection. JF - REP. FLA. SEA GRANT PROGRAM. pp. 15-17. 1991. AU - Hoskin, G P AU - Wilson, SE Y1 - 1991 PY - 1991 DA - 1991 SP - 15 EP - 17 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - FLSGP-W-90-001 KW - Marine KW - fishery products KW - microbial contamination KW - organizations KW - surveillance and enforcement KW - legislation KW - inspection KW - health and safety KW - joint ventures KW - seafood KW - quality control KW - safety regulations KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16662362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Food+and+Drug+Administration+and+National+Marine+Fisheries+Service+joint+seafood+initiative%3A+Status.&rft.au=Hoskin%2C+G+P%3BWilson%2C+SE&rft.aulast=Hoskin&rft.aufirst=G&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 ER - TY - CONF T1 - Report on emerging problems in seafoodborne parasitic zoonoses. AN - 16661497; 3018637 AB - The first international conference on foodborne parasitic zoonoses was held November 14-17 1990 at Chiang Mai University, Thailand. The meeting was organized by the Southeast Asian Ministers of Education. The 120 attended at the meeting were from 26 countries. Reports at the conference covered nearly all of the inhabited areas of the world, with emphasis on the clinical/epidemiological background as well as veterinary ramifications. The point of view of food science was represented by a minority of papers. The nomenclature ending for parasitic diseases -iosis- is that recommended by the International Congress on Zoonosis as a means for standardization. Presented in this paper is a discussion of the seafood aspects of the conference with the addition of some necessary background material. Major Objectives of the conference were to: assess the current status of foodborne parasitic illness throughout the world; describe current research activities in foodborne parasitic zoonoses; assess the impact of zoonotic and other foodborne parasitic illnesses on economics and industry; establish collaborative research efforts between conference attendeds with similar interests. Implications for the seafood industry worldwide are reviewed in this paper. JF - REP. FLA. SEA GRANT PROGRAM. pp. 213-225. 1991. AU - Bier, J W Y1 - 1991 PY - 1991 DA - 1991 SP - 213 EP - 225 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Aquaculture Abstracts KW - FLSGP-W-90-001 KW - fishery economics KW - Marine KW - fishery products KW - microbial contamination KW - parasitic diseases KW - geographical distribution KW - conferences KW - pathogens KW - Cryptosporidium parvum KW - oyster fisheries KW - oyster culture KW - human diseases KW - seafood KW - quality control KW - Crassostrea virginica KW - Q3 08583:Shellfish culture KW - Q1 08583:Shellfish culture KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16661497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Report+on+emerging+problems+in+seafoodborne+parasitic+zoonoses.&rft.au=Bier%2C+J+W&rft.aulast=Bier&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 ER - TY - CONF T1 - Recent advances in ciguatera fish poisoning research. AN - 16629534; 3018684 AB - Ciguatera, an illness caused by consumption of a variety of tropical and subtropical species of fish, remains a serious public health and economic problem in many areas of the world. It has been cited as the most frequent cause of illness due to seafood toxins in the United States. Once thought to be caused by one or possibly two toxins (ciguatoxin and maitotoxin) produced by a benthic dinoflagellate (Gambierdiscus toxicus ), it now appears to involve a number of distinct toxins which are elaborated by several species of dinoflagellates. Recent studies examining these toxins and species are discussed. JF - REP. FLA. SEA GRANT PROGRAM. 527 p. 1991. AU - Gramade. H.R. AU - Dickey, R Y1 - 1991 PY - 1991 DA - 1991 SP - 527 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - biological poisons KW - ciguatera KW - ciguatoxins KW - human diseases KW - poisonous organisms KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Marine Biotechnology Abstracts KW - FLSGP-W-90-001 KW - Marine KW - fishery products KW - Gambierdiscus toxicus KW - legislation KW - bioassays KW - Dinophyta KW - toxicity KW - seafood KW - Mugil cephalus KW - quality control KW - public health KW - Q4 27390:Toxins KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08622:Primary products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16629534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Recent+advances+in+ciguatera+fish+poisoning+research.&rft.au=Gramade.+H.R.%3BDickey%2C+R&rft.aulast=Gramade.+H.R.&rft.aufirst=&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Summary only. N1 - Last updated - 2014-05-06 ER - TY - CONF T1 - Toxic fractions of mullet (Mugil cephalus ) viscera. AN - 16591975; 3023915 AB - Four cases of human intoxication resulting from consumption of whole, grilled mullet occurred in California in 1990. The symptoms reported were consistent with those caused by marine polyether toxins such as ciguatoxin or brevetoxin. Fractions of mullet viscera were found toxic in a bioassay; however, the nature of the toxic component is unknown. Although the incidence is rare and limited, the consequences imply the necessity for appropriate care in procurement, distribution records, labeling and consumer education relative to whole fish marketed with viscera intact. JF - REP. FLA. SEA GRANT PROGRAM. 526 p. 1991. AU - Wekell, M M AU - Hungerford, J M AU - Hokamo, Y Y1 - 1991 PY - 1991 DA - 1991 SP - 526 PB - FLORIDA SEA GRANT COLL. PROGRAM, GAINESVILLE, FL (USA) KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - FLSGP-W-90-001 KW - Marine KW - fishery products KW - microbial contamination KW - Gambierdiscus toxicus KW - benthos KW - toxicity KW - human diseases KW - seafood KW - ciguatera KW - quality control KW - ciguatoxin KW - public health KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16591975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Toxic+fractions+of+mullet+%28Mugil+cephalus+%29+viscera.&rft.au=Wekell%2C+M+M%3BHungerford%2C+J+M%3BHokamo%2C+Y&rft.aulast=Wekell&rft.aufirst=M&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Summary only. N1 - Last updated - 2014-05-06 ER - TY - BOOK T1 - Epilogue. (Dioxin conference). AN - 16495258; 2945782 AB - Perhaps the most practical outcome of the meeting was that there was a sense of agreement that the model traditionally used to assess toxin risk is no longer appropriate and that all of the known toxic effects of dioxin appear to be receptor-mediated. This means that for dioxin to have an effect, an undetermined number of receptors must be occupied before any biological or toxic effect is seen, and thus there exists a dose level below which no biologically significant effects can occur. JF - BANBURY REPORT. 1991. AU - Scheuplein, R J AU - Gallo, MA AU - van der Heijden, KA A2 - Gallo, MA A2 - Scheuplein, RJ A2 - van der Heijden, KA (eds) Y1 - 1991 PY - 1991 DA - 1991 PB - COLD SPRING HARBOR LABORATORY PRESS, COLD SPRING HARBOR, NY (USA) SN - 0879692359 KW - PCB KW - epilogue KW - Toxicology Abstracts KW - reviews KW - conferences KW - receptors KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16495258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Scheuplein%2C+R+J%3BGallo%2C+MA%3Bvan+der+Heijden%2C+KA&rft.aulast=Scheuplein&rft.aufirst=R&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0879692359&rft.btitle=Epilogue.+%28Dioxin+conference%29.&rft.title=Epilogue.+%28Dioxin+conference%29.&rft.issn=01980068&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Targeting of workplace inspections for lead. AN - 16484001; 2935179 AB - The prevention of occupational lead poisoning requires identification of worksites with ongoing excessive lead exposures. The utility of different sources of surveillance data in identifying worksites was evaluated by comparing a list of companies inspected by the Occupational Safety and Health Administration (OSHA) for lead with 1) Ohio Bureau of Workers' Compensation (BWC) claims for lead poisoning, and 2) the New York Health Department's Heavy Metal Registry (NYHMR) reports of individuals with elevated blood lead levels. In both states, companies inspected by OSHA were concentrated in larger industries with traditional, well-recognized lead hazards. Companies identified by compensation claims and laboratory reports tended to be in industries dominated by smaller establishments where lead is not a primary part of the industrial process. Sources of surveillance data, such as workers' compensation claims and laboratory reports, identify worksites that tend not to be routinely inspected by OSHA and which need intervention to prevent excessive lead exposure. To maximize the impact of public health resources devoted to the elimination of occupational lead poisoning, follow-up efforts at companies identified by state health departments and workers' compensation systems offer an important opportunity to complement OSHA's inspection efforts. JF - American Journal of Industrial Medicine AU - Seligman, P J AU - Halperin, W E AD - NIOSH, R-21, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 381 EP - 390 VL - 20 IS - 3 SN - 0271-3586, 0271-3586 KW - OSHA KW - inspection KW - Pollution Abstracts KW - poisoning KW - industries KW - lead KW - occupational exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16484001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Targeting+of+workplace+inspections+for+lead.&rft.au=Seligman%2C+P+J%3BHalperin%2C+W+E&rft.aulast=Seligman&rft.aufirst=P&rft.date=1991-01-01&rft.volume=20&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2012-02-28 N1 - SubjectsTermNotLitGenreText - lead; occupational exposure; industries; poisoning ER - TY - JOUR T1 - Adverse behavioral reactions attributed to triazolam in the Food and Drug Administration's Spontaneous Reporting system. AN - 16408950; 2893673 AB - Reports of adverse behavioral reactions to triazolam, a triazolobenzodiazepine ultra-short-acting hypnotic, were examined in the postmarketing surveillance Spontaneous Reporting System of the Food and Drug Administration. Reports for triazolam of confusion, amnesia, bizarre behavior, agitation, and hallucinations were compared with reports of these reactions for temazepam, another short-acting hypnotic. Analysis of individual case reports from marketing through 1985 for triazolam vs temazepam showed 133 vs two for confusion, 109 vs three for amnesia, 59 vs two for bizarre behavior, 58 vs four for agitation, and 40 vs one for hallucinations. Considering extent of use, reporting rates for triazolam were 22 to 99 times those for temazepam, depending on the reaction. JF - Archives of Internal Medicine AU - Wysowski, D K AU - Barash, D AD - Div. Epidemiol. and Surveillance, Cent. Drug Eval. and Res., FDA, Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 2003 EP - 2008 VL - 151 IS - 10 SN - 0003-9926, 0003-9926 KW - triazolam KW - Toxicology Abstracts KW - side effects KW - hypnotics KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16408950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Internal+Medicine&rft.atitle=Adverse+behavioral+reactions+attributed+to+triazolam+in+the+Food+and+Drug+Administration%27s+Spontaneous+Reporting+system.&rft.au=Wysowski%2C+D+K%3BBarash%2C+D&rft.aulast=Wysowski&rft.aufirst=D&rft.date=1991-01-01&rft.volume=151&rft.issue=10&rft.spage=2003&rft.isbn=&rft.btitle=&rft.title=Archives+of+Internal+Medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - side effects; man; hypnotics ER - TY - JOUR T1 - Lung cancer incidence among patients with beryllium disease: A cohort mortality study. AN - 16340737; 2849818 AB - We have conducted a cohort mortality study on 689 patients with beryllium disease who were included in a case registry. Comparison of the 689 beryllium disease patients with the U.S. population resulted in a lung cancer standardized mortality ratio (SMR) of 2.00 based on 28 observed lung cancer deaths. Adjustment for smoking did not change these results. All causes of mortality were also significantly elevated, largely because of the very high rate of deaths due to pneumoconioses (primarily beryllium disease). No other causes of death were significantly elevated. The excess of lung cancer was consistent for both sexes and did not appear to increase with duration of exposure to beryllium or with time elapsed since first exposure to this element. JF - Journal of the National Cancer Institute AU - Steenland, K AU - Ward, E AD - Mailstop R13, NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1380 EP - 1385 VL - 83 IS - 19 SN - 0027-8874, 0027-8874 KW - disease KW - relationships KW - man KW - beryllium KW - lung cancer KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - lung KW - metals KW - cancer KW - X 24162:Chronic exposure KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16340737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lung+cancer+incidence+among+patients+with+beryllium+disease%3A+A+cohort+mortality+study.&rft.au=Steenland%2C+K%3BWard%2C+E&rft.aulast=Steenland&rft.aufirst=K&rft.date=1991-01-01&rft.volume=83&rft.issue=19&rft.spage=1380&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - beryllium; lung; cancer; metals; lung cancer; man ER - TY - CONF T1 - Validation of biological markers for quantitative risk assessment. AN - 16315766; 2826241 AB - The evaluation of biological markers is recognized as necessary to the future of toxicology, epidemiology, and quantitative risk assessment. For biological markers to become widely accepted, their validity must be ascertained. This paper explores the range of considerations that compose the concept of validity as it applies to the evaluation of biological markers. Three broad categories of validity (measurement, internal study, and external) are discussed in the context of evaluating data for use in quantitative risk assessment. Particular attention is given to the importance of measurement validity in the consideration of whether to use biological markers in epidemiologic studies. The concepts developed in this presentation are applied to examples derived from the occupational environment. In the first example, measurement of bromine release as a marker of ethylene dibromide toxicity is shown to be of limited use in constructing an accurate quantitative assessment of the risk of developing cancer as a result of long-term, low-level exposure. This example is compared to data obtained from studies of ethylene oxide, in which hemoglobin alkylation is shown to be a valid marker of both exposure and effect. JF - Environmental Health Perspectives AU - Schulte, P AU - Mazzuckelli, L F Y1 - 1991 PY - 1991 DA - 1991 SP - 239 EP - 246 VL - 90 KW - biology KW - markers KW - Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - toxicology KW - epidemiology KW - risk assessment KW - H SM3.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - R2 23060:Medical and environmental health KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16315766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Validation+of+biological+markers+for+quantitative+risk+assessment.&rft.au=Schulte%2C+P%3BMazzuckelli%2C+L+F&rft.aulast=Schulte&rft.aufirst=P&rft.date=1991-01-01&rft.volume=90&rft.issue=&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Interaction of copper with DNA and antagonism by other metals. AN - 16291873; 2808893 AB - Copper (Cu(II)) has been shown to enhance DNA damage in several biological systems. Binding of copper to DNA may be a key step in producing these lesions. The results of this study indicate that the DNA double helix contains at least two kinds of binding sites for copper. One site is present once every four nucleotides, has high affinity, and shows a cooperative effect. The other is an intercalating site for copper that is present in every base pair. This site is saturable, has a dissociation constant (K sub(d)) for CU(II) of 41 mu M. In single-stranded DNA, we found an average copper binding site every three nucleotides with lower affinity than in dsDNA. The binding of copper to DNA shows an unexpected high specificity when studied in the presence of other metallic ions. The relative efficacy of several divalent cations to antagonize Cu(II) binding was: Ni = Cd = Mg >> Zn = Hg > Ca > Pb >> Mn, while Cr(VI) enhanced Cu(II) binding to DNA. JF - Toxicology and Applied Pharmacology AU - Sagripanti, J-I AU - Goering, P L AU - Lamanna, A AD - (HFZ-113) CDRH, FDA, 12709 Twinbrook Pkwy, Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 477 EP - 485 VL - 110 IS - 3 SN - 0041-008X, 0041-008X KW - copper KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - antagonism KW - metals KW - DNA KW - interaction KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16291873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Interaction+of+copper+with+DNA+and+antagonism+by+other+metals.&rft.au=Sagripanti%2C+J-I%3BGoering%2C+P+L%3BLamanna%2C+A&rft.aulast=Sagripanti&rft.aufirst=J-I&rft.date=1991-01-01&rft.volume=110&rft.issue=3&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA; interaction; metals; antagonism ER - TY - JOUR T1 - Evaluation of sorbents for the collection and analysis of trace levels of airborne vapors: Bis(2-chloroethyl)sulfide (mustard), a case study. AN - 16291094; 2811535 AB - Investigations from the National Institute for Occupational Safety and Health (NIOSH) have conducted research on air monitoring methods that the Department of Defense uses for measuring the workplace and environmental concentrations of chemical warfare agents. This paper concerns works on part of this research which was aimed at evaluating sorbents for the collection of the blister agent bis(2-chloroethyl)sulfate, known as mustard or HD, from air. Twenty-three sorbents were screened and compared to Tenax, the currently-used sorbent. JF - Chemosphere AU - Posner, J C AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 461 EP - 472 VL - 22 IS - 5-6 SN - 0045-6535, 0045-6535 KW - mustard KW - air pollutants KW - vapor KW - munitions KW - bis(2-chloroethyl)sulfide KW - Pollution Abstracts KW - sorption KW - monitoring methods KW - chemicals KW - military KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16291094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Evaluation+of+sorbents+for+the+collection+and+analysis+of+trace+levels+of+airborne+vapors%3A+Bis%282-chloroethyl%29sulfide+%28mustard%29%2C+a+case+study.&rft.au=Posner%2C+J+C&rft.aulast=Posner&rft.aufirst=J&rft.date=1991-01-01&rft.volume=22&rft.issue=5-6&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - chemicals; sorption; military; monitoring methods ER - TY - JOUR T1 - Histamine and endotoxin contamination of hay and respirable hay dust. AN - 16261068; 2802534 AB - Three distinct samples collected from a barn in which an outbreak of respiratory problems occurred were examined for possible etiologic agents. No causal relationship could be established from the results of this study; however histamine concentrations as high as 0.5 ng/mg for bulk hay (in the absence of measurable creatinine levels) along with 6138.3 endotoxin units/mg of hay were present in the samples. Both endotoxin and histamine could be recovered from respirable hay dust. The authenticity of the histamine found in the hay was evaluated with high-performance liquid chromatography and radioimmunoassay. Histamine release caused by hay extracts was evaluated with the use of leukocytes from the farmer and a referent. Histamine is known to modulate the immune system, but the role of occupational or environmental exposure to histamine in respiratory disease is unknown. JF - Scandinavian Journal of Work, Environment & Health AU - Siegel, P D AU - Olenchock, SA AU - Sorenson, W G AU - Lewis, D M AU - Bledsoe, T A AU - May, J J AU - Pratt, D S AD - Biochem. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 276 EP - 280 VL - 17 IS - 4 SN - 0355-3140, 0355-3140 KW - hay KW - histamine KW - respiratory tract diseases KW - man KW - respiratory diseases KW - Pollution Abstracts; Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - endotoxins KW - occupational exposure KW - dust KW - X 24171:Microbial KW - H SI0.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES KW - J 02823:In vitro and in vivo effects KW - H SE2.8.7:DUST UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16261068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Histamine+and+endotoxin+contamination+of+hay+and+respirable+hay+dust.&rft.au=Siegel%2C+P+D%3BOlenchock%2C+SA%3BSorenson%2C+W+G%3BLewis%2C+D+M%3BBledsoe%2C+T+A%3BMay%2C+J+J%3BPratt%2C+D+S&rft.aulast=Siegel&rft.aufirst=P&rft.date=1991-01-01&rft.volume=17&rft.issue=4&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; endotoxins; respiratory diseases; occupational exposure; hay; respiratory tract diseases; man ER - TY - JOUR T1 - Cloning and sequencing of the structural gene for the porin protein of Bordetella pertussis . AN - 16256863; 2783246 AB - Bordetella pertussis produces a porin protein which is a prominent outer membrane component found in both virulent and avirulent strains. N-terminal amino acid analysis of purified B. pertussis porin was performed and this amino acid sequence was used to design an oligonucleotide that was then utilized to screen a lambda gt11 library containing randomly sheared fragments of DNA from B. pertussis strain 347. DNA hybridization studies indicated that both virulent and avirulent strains of B. pertussis contain only one copy of this gene and that Bordetella bronchiseptica and Bordetella parapetussie contain a similar gene. JF - Molecular Microbiology AU - Li, Z M AU - Hannah, J H AU - Stibitz, S AU - Nguyen, N Y AU - Manclark, C R AU - Brennan, MJ AD - Div. Bact. Prod., Cent. Biol. Eval. and Res., FDA, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1649 EP - 1656 VL - 5 IS - 7 SN - 0950-382X, 0950-382X KW - Bordetella pertussis KW - DNA KW - amino acid analysis KW - genes KW - hybridization analysis KW - nucleotide sequence KW - porins KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14640:Structure & sequence KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16256863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Cloning+and+sequencing+of+the+structural+gene+for+the+porin+protein+of+Bordetella+pertussis+.&rft.au=Li%2C+Z+M%3BHannah%2C+J+H%3BStibitz%2C+S%3BNguyen%2C+N+Y%3BManclark%2C+C+R%3BBrennan%2C+MJ&rft.aulast=Li&rft.aufirst=Z&rft.date=1991-01-01&rft.volume=5&rft.issue=7&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - nucleotide sequence; porins; hybridization analysis; genes; DNA ER - TY - JOUR T1 - Propanil: Toxicological characteristics, metabolism, and biodegradation potential in soil. AN - 16250933; 2777554 AB - Propanil (3',4'-dichloropropionanilide (DCPA)) is a biologically active pollutant. Propanil is extensively used around the world for control of weeds in rice (Oryza sativa L.) production. Although propanil by itself is of low toxicity, the highly toxic impurities 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) from the manufacture of 3,4-dichloroaniline (DCA) often contaminate the 3,4-DCA-derived herbicide propanil. In soil, biodegradation of propanil liberates DCA, which is converted by microbial peroxidases to TCAB and other azo products. The TCAB and TCAOB may accumulate in rice-growing soils, and leach into groundwater. The toxicity and fate of these compounds in the environment and the ability of microorganisms to detoxify them are discussed. JF - Journal of Environmental Quality AU - Pothuluri, J V AU - Hinson, JA AU - Cerniglia, CE AD - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 330 EP - 347 VL - 20 IS - 2 SN - 0047-2425, 0047-2425 KW - propanil KW - 3,4-dichloroaniline KW - formation KW - 3,3',4,4'-tetrachloroazobenzene KW - soils KW - Pollution Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - biodegradation KW - metabolism KW - toxicology KW - soil microorganisms KW - microorganisms KW - A 01054:Effect of herbicides KW - J 02901:Soil and plants KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16250933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Propanil%3A+Toxicological+characteristics%2C+metabolism%2C+and+biodegradation+potential+in+soil.&rft.au=Pothuluri%2C+J+V%3BHinson%2C+JA%3BCerniglia%2C+CE&rft.aulast=Pothuluri&rft.aufirst=J&rft.date=1991-01-01&rft.volume=20&rft.issue=2&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - soil microorganisms; biodegradation; toxicology; metabolism; microorganisms; formation ER - TY - JOUR T1 - The regulatory evolution of the integrated safety summary. AN - 16153744; 2703634 AB - It now seems perfectly obvious that the safety evaluation of a new drug must be based on an integrated summary, an overview, of the adverse event data from all sources, particularly all of the clinical trial data. Ie, safety evaluation is inherently a meta-analysis, although it is one whose rules are even less clear than the rules for effectiveness meta-analysis. The explicit recognition that the safety evaluation is an overview is relatively recent, and it does not appear that in the fairly recent past we expected the sponsor or the reviewer to take this approach. There were hints that an overview approach might be appropriate but the principal focus of the review and the sponsor's submission was the individual clinical studies, especially the controlled studies. JF - Drug Information Journal AU - Temple, R J AD - Off. Drug Eval. I, FDA, 5600 Fishers Lane HFN-100, Rm. 14B45, Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 485 EP - 492 VL - 25 IS - 4 SN - 0092-8615, 0092-8615 KW - pharmaceuticals KW - regulation KW - Toxicology Abstracts KW - side effects KW - safety KW - X 24230:Legislation & recommended standards KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16153744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=The+regulatory+evolution+of+the+integrated+safety+summary.&rft.au=Temple%2C+R+J&rft.aulast=Temple&rft.aufirst=R&rft.date=1991-01-01&rft.volume=25&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - safety; side effects ER - TY - JOUR T1 - An overview of gamma -hydroxybutyrate catabolism: The role of the cytosolic NADP super(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway. AN - 16146788; 2699438 JF - Neurochemical Research AU - Kaufman, EE AU - Nelson, T AD - Natl. Inst. Mental Health, United States Public Health Service, Dep. Health Human Serv., Build. 36, 1A-05, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 965 EP - 974 VL - 16 IS - 9 SN - 0364-3190, 0364-3190 KW - catabolism KW - cytosol KW - gamma -hydroxybutyrate KW - glucuronate reductase KW - hydroxyacid-oxoacid transhydrogenase KW - mitochondria KW - reviews KW - role KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Marine KW - Brackish KW - Freshwater KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16146788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=An+overview+of+gamma+-hydroxybutyrate+catabolism%3A+The+role+of+the+cytosolic+NADP+super%28%2B%29-dependent+oxidoreductase+EC+1.1.1.19+and+of+a+mitochondrial+hydroxyacid-oxoacid+transhydrogenase+in+the+initial%2C+rate-limiting+step+in+this+pathway.&rft.au=Kaufman%2C+EE%3BNelson%2C+T&rft.aulast=Kaufman&rft.aufirst=EE&rft.date=1991-01-01&rft.volume=16&rft.issue=9&rft.spage=965&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - reviews; Marine; Brackish; Freshwater ER - TY - JOUR T1 - Completeness of adverse drug experience reporting by manufacturers to the FDA. AN - 16140685; 2688301 AB - This project evaluated the completeness of manufacturer adverse drug experience (ADE) reports on computerized fields on the FDA-1639 form for which completion is not required for data entry, (eg, age, sex, ADE onset date). The completion rate of such fields was determined for domestic, spontaneous, health professional-submitted ADE reports during 1986-1989. This project was limited to 20 manufacturers submitting the largest number of reports. Completion rates were computed for total reports and 15-day reports. A completion rate was defined for each field for each manufacturer as the number of times the field was filled in divided by the total number of reports. JF - Drug Information Journal AU - Britt, AL AU - Knapp, DE AU - Anello, C AU - Perry, Z A AD - HFD-737, FDA, 5600 Fishers Ln., Rockville, MD 20857, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 599 EP - 606 VL - 25 IS - 4 SN - 0092-8615, 0092-8615 KW - pharmaceuticals KW - surveillance KW - Toxicology Abstracts KW - side effects KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16140685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Completeness+of+adverse+drug+experience+reporting+by+manufacturers+to+the+FDA.&rft.au=Britt%2C+AL%3BKnapp%2C+DE%3BAnello%2C+C%3BPerry%2C+Z+A&rft.aulast=Britt&rft.aufirst=AL&rft.date=1991-01-01&rft.volume=25&rft.issue=4&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - side effects ER - TY - CONF T1 - USFDA assessment of exposure to 2,3,7,8-TCDD 2,3,7,8-TCDF from foods contacting bleached paper products. AN - 16140527; 2688129 AB - Migration studies with paper food-contact articles thought to represent the greatest potential for exposure to 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) showed that measurable migration occurred with all articles tested. The Food and Drug Administration (FDA) combined these results with food consumption estimates to evaluate potential exposure to TCDD and TCDF from bleached paper food-contact articles. JF - Chemosphere AU - Cramer, G AU - Bolger, M AU - Henry, S AU - Lorentzen, R Y1 - 1991 PY - 1991 DA - 1991 SP - 1537 EP - 1550 VL - 23 IS - 8-10 KW - TCDD KW - paper products KW - FDA KW - TCDF KW - foods KW - 2,3,7,8-tetrachlorodibenzofuran KW - paper KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - food KW - contamination KW - H SE4.27:FOOD PROCESSING INDUSTRIES KW - X 24120:Food, additives & contaminants KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16140527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=USFDA+assessment+of+exposure+to+2%2C3%2C7%2C8-TCDD+2%2C3%2C7%2C8-TCDF+from+foods+contacting+bleached+paper+products.&rft.au=Cramer%2C+G%3BBolger%2C+M%3BHenry%2C+S%3BLorentzen%2C+R&rft.aulast=Cramer&rft.aufirst=G&rft.date=1991-01-01&rft.volume=23&rft.issue=8-10&rft.spage=1537&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - PAT T1 - Assay for Mycoplasma fermentans . AN - 16140521; 2680227 AB - An assay for detecting the presence of Mycoplasma fermentans comprises the steps of: obtaining a nuclear extract from a sample of cells suspected of the presence of Mycoplasma fermentans ; and testing the extract for Mfe I activity, the presence of Mfe I activity being indicative of the presence of Mycoplasma fermentans . AU - Leonard, W J AU - Wolf, J B AU - Halden, N F PY - 1991 IS - US Patent 5,073,486 KW - detection KW - extracts KW - Mfe I activity KW - Mycoplasma fermentans KW - nuclei KW - patents KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - W 30050:Patents KW - A 01114:Viruses KW - W 30507:Diagnostic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16140521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Assay+for+Mycoplasma+fermentans+.&rft.au=Leonard%2C+W+J%3BWolf%2C+J+B%3BHalden%2C+N+F&rft.aulast=Leonard&rft.aufirst=W&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/19; Int. Cl. C12R 1/35, C12Q 1/34, C12N 9/22. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Evaluation of chronic bronchitis, chronic obstructive pulmonary disease, and ventilatory function among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. AN - 16136655; 2688037 AB - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is produced as an undesirable contaminant in the manufacture of 2,4,5-trichlorophenol (TCP) and its derivatives. There is considerable concern about the health effects that may be associated with exposure to TCDD-contaminated substances. A cross-sectional medical study that included a comprehensive medical history, medical examination, and measurement of pulmonary function was conducted on workers employed more than 15 yr earlier in the manufacture of NaTCP and its derivatives at two chemical plants. No difference was found between workers and referents in the risk for chronic bronchitis or COPD. Analysis of the ventilatory function data revealed no association between history of exposure to substances contaminated with TCDD and the forced expiratory volume at one second (FEV sub(1)), forced vital capacity (FVC), or the ratio of FEV sub(1) to FVC (FEV sub(1)/FVC%). JF - American Journal of Respiratory and Critical Care Medicine AU - Calvert, G M AU - Sweeney, M H AU - Morris, JA AU - Fingerhut, MA AU - Hornung, R W AU - Halperin, W E AD - NIOSH, 4676 Columbia Pkwy., R-16, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 1303 EP - 1306 VL - 144 IS - 6 SN - 0003-0805, 0003-0805 KW - TCDD KW - function KW - bronchitis KW - chronic obstructive pulmonary disease KW - man KW - respiratory tract diseases KW - respiratory diseases KW - occupational health KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - lung KW - occupational exposure KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16136655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Evaluation+of+chronic+bronchitis%2C+chronic+obstructive+pulmonary+disease%2C+and+ventilatory+function+among+workers+exposed+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Calvert%2C+G+M%3BSweeney%2C+M+H%3BMorris%2C+JA%3BFingerhut%2C+MA%3BHornung%2C+R+W%3BHalperin%2C+W+E&rft.aulast=Calvert&rft.aufirst=G&rft.date=1991-01-01&rft.volume=144&rft.issue=6&rft.spage=1303&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational exposure; lung; respiratory diseases; occupational health; chronic obstructive pulmonary disease; man; respiratory tract diseases ER - TY - JOUR T1 - Co-amplification of specific sequences of HCV and HIV-1 genomes by using the polymerase chain reaction assay: A potential tool for the simultaneous detection of HCV and HIV-1. AN - 16129602; 2686693 AB - A rapid and simple method using the polymerase chain reaction (PCR) was devised for the co-amplification and simultaneous detection of hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) specific sequences in the same serum sample. Genomic RNA was extracted from 13 blood donor sera that were reactive in ELISA for both anti-HCV and anti-HIV-1. The extracted RNA was reverse transcribed into cDNA and amplified using nested primer pairs (SN01 and SN04; SN02 and SN03) based on the HCV prototype sequence of clones 37b and 81, and SK 38/39 for HIV-1 simultaneously. The ability to co-amplify specific sequences from two different viral genomes in the same reaction mixture offers the possibility of simultaneous detection and diagnosis of more than one viral agent in serum samples of infected individuals. JF - Journal of Virological Methods AU - Nedjar, S AU - Biswas, R M AU - Hewlett, I K AD - DTS, CBER, FDA, 8800 Rockville Pike, Build. 29/B-03, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 297 EP - 304 VL - 35 IS - 3 SN - 0166-0934, 0166-0934 KW - human immunodeficiency virus 1 KW - oligonucleotides KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - nucleotide sequence KW - RNA KW - hybridization analysis KW - cDNA KW - genes KW - V 22002:AIDS: Molecular and in vitro aspects KW - A 01114:Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16129602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Co-amplification+of+specific+sequences+of+HCV+and+HIV-1+genomes+by+using+the+polymerase+chain+reaction+assay%3A+A+potential+tool+for+the+simultaneous+detection+of+HCV+and+HIV-1.&rft.au=Nedjar%2C+S%3BBiswas%2C+R+M%3BHewlett%2C+I+K&rft.aulast=Nedjar&rft.aufirst=S&rft.date=1991-01-01&rft.volume=35&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - genes; nucleotide sequence; RNA; cDNA; hybridization analysis ER - TY - PAT T1 - Nucleotide, deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins. AN - 16128821; 2677175 AU - Morrison, R P AU - Caldwell, H D PY - 1991 IS - US Patent 5,071,962 KW - patents KW - Chlamydia KW - amino acid sequence KW - heat-shock proteins KW - proteins KW - Biotechnology and Bioengineering Abstracts KW - W 30404:Other peptides and proteins KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16128821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Nucleotide%2C+deduced+amino+acid+sequence%2C+isolation+and+purification+of+heat-shock+chlamydial+proteins.&rft.au=Morrison%2C+R+P%3BCaldwell%2C+H+D&rft.aulast=Morrison&rft.aufirst=R&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 530/387; Int. Cl. A61K 35/14, C07K 3/00, 13/00, 15/00. N1 - Last updated - 2011-12-13 ER - TY - PAT T1 - Method of treatment of hepatitis. AN - 16112545; 2662107 AB - A method for treating hepatitis B comprises administering to a patient infected with hepatitis B an anti-hepatitis B effective amount of a nucleoside selected from the group consisting of 2',3'-dideoxyinosine, 2',3'-dideoxyadenosine, and 2',3'-dideoxyguanosine. AU - Hoofnagle, J H AU - Broder, S AU - Mitsuya, H AU - Yarchoan, R PY - 1991 IS - US Patent 5,070,077 KW - patents KW - nucleosides KW - 2',3'-dideoxyinosine KW - 2',3'-dideoxyadenosine KW - 2',3'-dideoxyguanosine KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antiviral agents KW - hepatitis B virus KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16112545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Method+of+treatment+of+hepatitis.&rft.au=Hoofnagle%2C+J+H%3BBroder%2C+S%3BMitsuya%2C+H%3BYarchoan%2C+R&rft.aulast=Hoofnagle&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/45; Int. Cl. A61K 31/70. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Regulatory concerns in human gene therapy. AN - 16103468; 2661559 AB - Gene therapy in humans is now being undertaken in an investigational setting. Such therapy involves the administration of biological products to human patients. A document entitled, "Points to Consider in Human Somatic Cell Therapy and Gene Therapy" has been prepared by the Center for Biologics Evaluation and Research (CBER) of the Food and Drug Administration (FDA) and is published elsewhere in this issue. This paper provides explanatory material about the CBER regulatory process and the scientific and regulatory basis for the requests for data in that document. JF - Human Gene Therapy AU - Epstein, S L AD - FDA, CBER, OBR, DBB, Build. 29, Rm. 522, HFB-710, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 243 EP - 249 VL - 2 IS - 3 SN - 1043-0342, 1043-0342 KW - gene transfer KW - man KW - gene therapy KW - government policy KW - government regulations KW - legal aspects KW - genetic engineering KW - genetics KW - safety KW - safety regulations KW - Risk Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - R2 23090:Policy and planning KW - W 30121:Transduction and transfection KW - W 30506:Therapeutic KW - H SM5.5:STANDARDS, LAWS, REGULATIONS, AND POLICY KW - G 07439:General - reviews/ethics, etc. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16103468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Regulatory+concerns+in+human+gene+therapy.&rft.au=Epstein%2C+S+L&rft.aulast=Epstein&rft.aufirst=S&rft.date=1991-01-01&rft.volume=2&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - genetic engineering; safety regulations; government regulations; genetics; safety; legal aspects; government policy ER - TY - PAT T1 - Treatment of a microbial infection with drugs containing para-acetamidobenzoic acid. AN - 16091607; 2650695 AU - Kovacs, J AU - Masur, H AU - Allegra, C PY - 1991 IS - US Patent 5,068,253 KW - patents KW - p-acetamidobenzoic acid KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antimicrobial agents KW - A 01069:Antimicrobial & microbiocidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16091607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Treatment+of+a+microbial+infection+with+drugs+containing+para-acetamidobenzoic+acid.&rft.au=Kovacs%2C+J%3BMasur%2C+H%3BAllegra%2C+C&rft.aulast=Kovacs&rft.aufirst=J&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/553; Int. Cl. A61K 31/185. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Characterisation of respiratory health and exposures at a sintered permanent magnet manufacturer. AN - 16081943; 2645425 AB - Sintered permanent magnets are made from the powdered metals of cobalt, nickel, aluminium, and various rare earths. During production, exposure to respirable crystalline silica and asbestos may also occur. Reported here is a cross sectional study of 310 current and 52 retired hourly employees who worked 10 or more years making sintered magnets. Each participant had a chest radiograph, spirometry, and completed a respiratory questionnaire. Illness logs were also reviewed to calculate the incidence of recorded respiratory disorders. The prevalences of abnormalities in pulmonary function and respiratory symptoms were not higher than found in an external referent population. Although the prevalence of diffuse parenchymal opacities consistent with pneumoconiosis (four workers) was similar to the referent population, one worker had radiographic findings consistent with silicosis and two workers had profusion scores of 1/2 or above, not seen in the referent group. JF - Occupational and Environmental Medicine AU - Deng, Jou-Fang AU - Sinks, T AU - Elliott, L AU - Smith, D AU - Singal, M AU - Fine, L AD - Div. Surveill., NIOSH, 4676 Columbia Pkwy., R-10, Cincinnati, OH 45261, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 609 EP - 615 VL - 48 IS - 9 SN - 0007-1072, 0007-1072 KW - respiratory system KW - humans KW - magnet manufacturer KW - occupational health KW - silicon dioxide KW - asbestos KW - occupational hazards KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - silicosis KW - metals KW - pneumoconiosis KW - H SI2.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16081943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Characterisation+of+respiratory+health+and+exposures+at+a+sintered+permanent+magnet+manufacturer.&rft.au=Deng%2C+Jou-Fang%3BSinks%2C+T%3BElliott%2C+L%3BSmith%2C+D%3BSingal%2C+M%3BFine%2C+L&rft.aulast=Deng&rft.aufirst=Jou-Fang&rft.date=1991-01-01&rft.volume=48&rft.issue=9&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - metals; occupational health; pneumoconiosis; asbestos; silicosis; occupational hazards ER - TY - PAT T1 - Kit for diagnosing cancer metastatic potential. AN - 16074225; 2634220 AU - Steeg, P S AU - Liotta, LA AU - Sobel, ME AU - Bevilacqua, G PY - 1991 IS - US Patent 5,049,662 KW - patents KW - NM23 gene KW - diagnosis KW - cancer KW - genes KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16074225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Kit+for+diagnosing+cancer+metastatic+potential.&rft.au=Steeg%2C+P+S%3BLiotta%2C+LA%3BSobel%2C+ME%3BBevilacqua%2C+G&rft.aulast=Steeg&rft.aufirst=P&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 536/27; Int. Cl. C07H 15/12, 17/00; C12Q 1/68. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Quantitative determination of trucking industry workers' exposures to diesel exhaust particles. AN - 16072587; 2640641 AB - As part of a case-control mortality study of trucking industry workers, exposures to diesel aerosol were measured among the four major presumably exposed job groups (road divers, local divers, dock workers, and mechanics) in the industry. Eight industrial hygiene surveys were conducted during both warm and cold weather at eight U.S. terminals and truck repair shops. A single-state personal impactor was used to sample submicrometer-sized diesel particles on quartz-fiber filters. Laboratory and field studies demonstrated that the elemental carbon content of the particles is a useful and practical maker of exposure to vehicular diesel exhaust. A thermal-optical analysis technique was used to determine the concentration of elemental carbon in the filter samples. Overall geometric mean exposures to submicrometer-sized elemental carbon ranged from 3.8 mu g/m super(3) in road (long distance) drivers (N = 72) to 13.8 mu g/m super(3) in dock workers (N = 75). JF - American Industrial Hygiene Association Journal AU - Zaebst, D D AU - Clapp, DE AU - Blade, L M AU - Marlow, DA AU - Steenland, K AU - Hornung, R W AU - Scheutzle, D AU - Butler, J AD - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 529 EP - 541 VL - 52 IS - 12 SN - 0002-8894, 0002-8894 KW - trucks KW - Health & Safety Science Abstracts; Pollution Abstracts KW - occupational health KW - air sampling KW - particle size KW - exhaust emissions KW - mortality KW - aerosols KW - filters KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - H ST2.21:TRUCKS KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16072587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Quantitative+determination+of+trucking+industry+workers%27+exposures+to+diesel+exhaust+particles.&rft.au=Zaebst%2C+D+D%3BClapp%2C+DE%3BBlade%2C+L+M%3BMarlow%2C+DA%3BSteenland%2C+K%3BHornung%2C+R+W%3BScheutzle%2C+D%3BButler%2C+J&rft.aulast=Zaebst&rft.aufirst=D&rft.date=1991-01-01&rft.volume=52&rft.issue=12&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - exhaust emissions; aerosols; particle size; air sampling; filters; occupational health; mortality ER - TY - JOUR T1 - Purification and characterization of an endotoxin-binding protein with protease inhibitory activity from Limulus amebocytes. AN - 16062778; 2627971 AB - Using a lipopolysaccharide affinity column and ion exchange chromatography, a 12-kDa protein has been purified from Limulus amebocytes. A cDNA coding for this protein has been isolated and sequenced. The amino acid sequence deduced from the cDNA indicates that this protein shares no sequence homology with LPS-binding proteins isolated from different species of vertebrates and invertebrates. Using both ( super(14)C)casein and a synthetic substrate, the protein has been shown to inhibit the proteolytic activity of trypsin, with an IC sub(50) of similar to 10 super(-7) M. In the presence of LPS, the antitryptic activity of the Limulus endotoxin-binding protein-protease inhibitor remains unaffected. The protein is a major component of the cytoplasmic proteins (1%). Immunocytochemical analysis reveals that this protein exists in the secretory granules of the amebocytes where enzymes and substrates for the clotting cascade reside. Based on the unusual dual functional properties, the newly isolated protein was named a "Limulus endotoxin-binding protein-protease inhibitor" (LEBP-PI). JF - Journal of Biological Chemistry AU - Minetti, CASA AU - Lin, Yuan AU - Cislo, T AU - Liu, Teh-Yung AD - Div. Biochem. and Biophys., Cent. Biol. Eval. and Res., FDA, Rm. 516, Build. 29, 8800 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 20773 EP - 20780 VL - 266 IS - 31 SN - 0021-9258, 0021-9258 KW - Limulus KW - amino acid sequence KW - amino acids KW - amoebocytes KW - chemical extraction KW - endotoxin-binding protein KW - enzymatic activity KW - enzyme inhibitors KW - inhibitors KW - predictions KW - protease inhibitors KW - protein synthesis KW - proteinase KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Q1 08286:Physiology, biochemistry, biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16062778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Purification+and+characterization+of+an+endotoxin-binding+protein+with+protease+inhibitory+activity+from+Limulus+amebocytes.&rft.au=Minetti%2C+CASA%3BLin%2C+Yuan%3BCislo%2C+T%3BLiu%2C+Teh-Yung&rft.aulast=Minetti&rft.aufirst=CASA&rft.date=1991-01-01&rft.volume=266&rft.issue=31&rft.spage=20773&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - protein synthesis; enzyme inhibitors; amoebocytes; chemical extraction; amino acids; Marine ER - TY - JOUR T1 - DNA strand breaks and DNA repair response in lymphocytes after chronic in vivo exposure to very low doses of ionizing radiation in mice. AN - 16061254; 2617263 AB - We have examined whether whole-body exposure to low-dose radiation (LDR) results in an alteration in constitutive (steady state) levels of DNA-strand breaks and whether an adaptive increase in DNA-repair response is induced. The results indicated that the constitutive expression of DNA-strand breaks is significantly decreased after chronic LDR; however, DNA-repair capacity after high-dose radiation exposure is not increased above that observed in sham-irradiated mice. JF - Mutation Research AU - James, S J AU - Enger, S M AU - Makinodan, T AD - Dep. Health and Hum. Serv., FDA, Natl. Cent. Toxicol. Res., Div. Comp. Toxicol., NCTR Dr., Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 255 EP - 263 VL - 249 IS - 1 SN - 0027-5107, 0027-5107 KW - gamma radiation KW - strands KW - breaks KW - mice KW - Toxicology Abstracts; Genetics Abstracts KW - DNA KW - DNA repair KW - X 24210:Radiation & radioactive materials KW - G 07231:Radiation (gamma) KW - G 07420:GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16061254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=DNA+strand+breaks+and+DNA+repair+response+in+lymphocytes+after+chronic+in+vivo+exposure+to+very+low+doses+of+ionizing+radiation+in+mice.&rft.au=James%2C+S+J%3BEnger%2C+S+M%3BMakinodan%2C+T&rft.aulast=James&rft.aufirst=S&rft.date=1991-01-01&rft.volume=249&rft.issue=1&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA repair; DNA ER - TY - JOUR T1 - Mathematical modeling of reproductive and developmental toxic effects for quantitative risk assessment. AN - 16055659; 2613144 AB - A new mathematical dose-response model for reproductive and developmental risk assessment is proposed. The model includes the possibility of an exposure threshold as well as a litter-size effect. Correlation of responses of offspring from the same litter is taken into account through the use of the beta-binomial distribution. Confidence limits for low-dose extrapolation are based on the asymptotic distribution of the likelihood ratio. An empirical comparison of the proposed procedure to that of Rai and Van Ryzin demonstrates the improvement that can be achieved with the new procedure. JF - Risk Analysis AU - Kodell, R L AU - Howe, R B AU - Chen, J J AU - Gaylor, D W AD - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 583 EP - 590 VL - 11 IS - 4 SN - 0272-4332, 0272-4332 KW - mathematical models KW - dose response effects KW - Risk Abstracts; Pollution Abstracts KW - toxicity KW - statistical analysis KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16055659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Mathematical+modeling+of+reproductive+and+developmental+toxic+effects+for+quantitative+risk+assessment.&rft.au=Kodell%2C+R+L%3BHowe%2C+R+B%3BChen%2C+J+J%3BGaylor%2C+D+W&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-01-01&rft.volume=11&rft.issue=4&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - toxicity; statistical analysis ER - TY - JOUR T1 - Effects of neonatal diethylstilbestrol exposure on the growth of mouse vaginal epithelial cells in serum-free collagen gel culture. AN - 16050657; 2608444 AB - Vaginal epithelial cells isolated from ovariectomized ca. 40-day-old BALB/cCrgl mice treated with 1 mu g diethylstilbestrol (DES) or with oil vehicle alone for the first 5 days after birth were purified by Percoll density gradient centrifugation and grown as primary cultures in collagen gel matrix (CGM) with serum-free medium. Three dimensional colonies of both control and DES-exposed vaginal epithelial cells developed in the CGM. The initial proliferation rate of DES-exposed vaginal epithelial cells was significantly lower than that of the controls. After 10 days in culture, approximately 6.3-fold and 7.6-fold increases in cell number occurred in control and DES-exposed vaginal epithelial cells, respectively, a difference that is not significant. Deletion of bovine serum albumin, bovine insulin or mouse epidermal growth factor (EGF) resulted in decreased growth of both control and DES-exposed vaginal epithelial cells. Estradiol-17 beta (180 fM to 18 nM) did not stimulate growth of control or DES-exposed vaginal epithelial cells. JF - Zoological Science AU - Uchima, F-DA AU - Iguchi, T AU - Pattamakom, S AU - Mills, K T AU - Bern, HA AD - Dep. Integr. Biol., Univ. California, Berkeley, CA 94720, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 713 EP - 719 VL - 8 IS - 4 SN - 0289-0003, 0289-0003 KW - diethylstilbestrol KW - tissue culture KW - growth KW - mice KW - Toxicology Abstracts KW - prenatal experience KW - vagina KW - epithelium KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16050657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zoological+Science&rft.atitle=Effects+of+neonatal+diethylstilbestrol+exposure+on+the+growth+of+mouse+vaginal+epithelial+cells+in+serum-free+collagen+gel+culture.&rft.au=Uchima%2C+F-DA%3BIguchi%2C+T%3BPattamakom%2C+S%3BMills%2C+K+T%3BBern%2C+HA&rft.aulast=Uchima&rft.aufirst=F-DA&rft.date=1991-01-01&rft.volume=8&rft.issue=4&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Zoological+Science&rft.issn=02890003&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - prenatal experience; vagina; epithelium ER - TY - JOUR T1 - Additive and multiplicative relative risk in the two-stage clonal expansion model of carcinogenesis. AN - 16047976; 2614155 AB - The effects of exposure to two carcinogens are explored within the context of the two-stage clonal expansion model of carcinogenesis. This biologically based model provides a useful framework for the quantitative description of carcinogenesis, and for defining carcinogenic agents that act as initiators, promoters, and completers. This paper addresses the combined effects of simultaneous lifetime exposure to two carcinogens as well as nonoverlapping partial lifetime exposure to each agent. Whereas the age-specific relative risk for exposure to two initiators or two completers is additive, a multiplicative relative risk model holds for exposure to an initiator and a completer, or to a promoter and a completer. Exposure to two promoters yields supra-multiplicative relative risk. JF - Risk Analysis AU - Kodell, R L AU - Krewski, D AU - Zielinski, J M AD - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 483 EP - 490 VL - 11 IS - 3 SN - 0272-4332, 0272-4332 KW - carcinogenesis KW - Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - genotoxicity KW - mathematical models KW - risk assessment KW - H SM5.2:DATA ANALYSIS KW - R2 23060:Medical and environmental health KW - R2 23010:General: Models, forecasting KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16047976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Additive+and+multiplicative+relative+risk+in+the+two-stage+clonal+expansion+model+of+carcinogenesis.&rft.au=Kodell%2C+R+L%3BKrewski%2C+D%3BZielinski%2C+J+M&rft.aulast=Kodell&rft.aufirst=R&rft.date=1991-01-01&rft.volume=11&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - risk assessment; mathematical models; genotoxicity ER - TY - JOUR T1 - Genotoxicity of diesel-exhaust particles dispersed in simulated pulmonary surfactant. AN - 16047925; 2606228 AB - Diesel-exhaust particles from two sources were dispersed in aqueous mixtures of dipalmitoyl phosphatidyl choline, a major component of pulmonary surfactant, and were tested for genotoxicity. Diesel samples from the same sources were extracted with dichloromethane and transferred into dimethyl sulfoxide and subjected to the same assays. Both types of extractions yielded similar results in both the Salmonella mutagenicity assay and the sister-chromatid exchange assay using V79 cells. After separation of the samples into supernatant and sediment fractions, the activity of both diesel samples was shown to reside exclusively in the supernatant fraction for the solvent-extracted samples, and exclusively in the sedimented fraction for surfactant dispersed samples. JF - Mutation Research AU - Keane, MJ AU - Xing, S-G AU - Harrison, J C AU - Ong, T AU - Wallace, W E AD - Cent. Dis. Control, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 233 EP - 238 VL - 260 IS - 3 SN - 0027-5107, 0027-5107 KW - particles KW - fuels KW - diesel KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - mutation KW - sister chromatid exchange KW - genotoxicity KW - exhausts KW - Ames test KW - lung KW - surfactants KW - H SM5.8.2:CHEMICALS (CORROSION) KW - X 24155:Biochemistry KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16047925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Genotoxicity+of+diesel-exhaust+particles+dispersed+in+simulated+pulmonary+surfactant.&rft.au=Keane%2C+MJ%3BXing%2C+S-G%3BHarrison%2C+J+C%3BOng%2C+T%3BWallace%2C+W+E&rft.aulast=Keane&rft.aufirst=MJ&rft.date=1991-01-01&rft.volume=260&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - exhausts; mutation; genotoxicity; Ames test; sister chromatid exchange; lung; surfactants ER - TY - JOUR T1 - Nonisocyanate exposures in three flexible polyurethane manufacturing facilities. AN - 16033099; 2605960 AB - Workers were found to have respiratory and probably dermal exposure to methylene chloride in each facility. Traces of nitrogen dioxide and some aliphatic amines were evident. However, N-nitrosamines were not found. Exposure to thermal degradation products, polyurethane dust, and to flame retardants does not appear to be a problem under reasonable hygienic conditions. However, evidence for the existence of acrolein and acrylonitrile was found in one facility due to the thermal degradation of finished foam. Mutagenic activity, appearing only in the particulate fraction, appeared highest when the total isocyanate group air concentrations (TRIG) were also high. In one facility, the mutagenic activity was up to 75 times higher than the mutagenic activity of the outside air. The methods used to characterize each of the exposures are provided and the results are discussed. JF - Applied Occupational and Environmental Hygiene AU - Boeniger, M F AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 46226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 945 EP - 952 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - polyurethane KW - toluene diisocyanate KW - Pollution Abstracts; Health & Safety Science Abstracts KW - dust KW - occupational health KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI8.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16033099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Nonisocyanate+exposures+in+three+flexible+polyurethane+manufacturing+facilities.&rft.au=Boeniger%2C+M+F&rft.aulast=Boeniger&rft.aufirst=M&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; dust ER - TY - JOUR T1 - Effects of thermal environment and chemical protective clothing on work tolerance, physiological responses, and subjective ratings. AN - 16032930; 2601867 AB - This study examined the physiological and subjective responses of nine healthy men who performed work while wearing two types of protective ensembles in each of three thermal environments. The subjects, all experienced with the use of protective ensembles, each performed low intensity treadmill exercise (23% of VO sub(2) max while not wearing a Self-Contained Breathing Apparatus (SCBA) or protective clothing) under six experimental conditions: two ensembles during exposure to 'cool", "neutral", and "hot" environments. Each test was intended to continue for 120 min; however the duration and number of work/rest periods within the testing session varied according to the specific responses of each individual. JF - Ergonomics AU - White, M K AU - Hodous, T K AU - Vercruyssen, M AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 445 EP - 457 VL - 34 IS - 4 SN - 0014-0139, 0014-0139 KW - protective clothing KW - Health & Safety Science Abstracts KW - physiology KW - ergonomics KW - temperature KW - H SI6.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16032930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Effects+of+thermal+environment+and+chemical+protective+clothing+on+work+tolerance%2C+physiological+responses%2C+and+subjective+ratings.&rft.au=White%2C+M+K%3BHodous%2C+T+K%3BVercruyssen%2C+M&rft.aulast=White&rft.aufirst=M&rft.date=1991-01-01&rft.volume=34&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - physiology; temperature; ergonomics ER - TY - JOUR T1 - Control of wood dust from disc sanders. AN - 16032539; 2605704 AB - Association between nasal cancer and other health effects and occupations involving exposure to wood dust has been clearly established in the literature. This article reports on the research that has been conducted by scientists at the National Institute for Occupational Safety and Health (NIOSH) to reduced wood dust emissions from large-diameter disc sanders. An air jet stripper system was developed to be used in conjunction with existing local exhaust ventilation to reduce dust emissions. The system consists of a set of jets located inside the local exhaust hood. The jets are supplied with pressurized air. The control system, combined with currently existing controls, reduced wood dust emissions (area and breathing zone) by an average of 60 percent. Laboratory results were confirmed by field tests conducted at a wood furniture manufacturing plant. The control system does not interfere with the worker's activity, requires minimum maintenance, and is inexpensive to install and operate. JF - Applied Occupational & Environmental Hygiene AU - Hampl, V AU - Johnston, O E AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 938 EP - 944 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - wood KW - Pollution Abstracts; Health & Safety Science Abstracts KW - air stripping KW - occupational health KW - control systems KW - ventilation KW - emission control KW - dust KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI0.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16032539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Control+of+wood+dust+from+disc+sanders.&rft.au=Hampl%2C+V%3BJohnston%2C+O+E&rft.aulast=Hampl&rft.aufirst=V&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; occupational health; air stripping; ventilation; emission control; control systems ER - TY - JOUR T1 - Analysis of urine to monitor exposures to benzidine, o-dianisidine, o-tolidine, and 4,4'-methylenedianiline. AN - 16029876; 2605956 AB - Aromatic diamines have great potential for dermal absorption as an exposure route. Also, the body exhibits the ability to reductively cleave an azo dye to its corresponding aromatic diamine. These factors have demonstrated the need for biological monitoring to complement environmental monitoring when assessing occupational exposures to these compounds. This is especially important since certain aromatic diamines are known or are potential human carcinogens. Therefore, a sampling and analytical procedure for the measurement of benzidine, o-dianisidine, o-tolidine, and 4,4'-methylenedianiline in urine was developed for use in industrial hygiene investigations. After hydrolysis of urine metabolites, the free diamines are isolated using a C sub(18) solid sorbent. The free diamines are eluted, concentrated, and injected into a high-performance liquid chromatography system. JF - Applied Occupational and Environmental Hygiene AU - Neumeister, CE AD - U.S. DHHS, Public Health Serv., NIOSH, Div. Phys. Sci. and Eng., Meas. Res. Support Branch, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 953 EP - 958 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - metabolites KW - absorption KW - Health & Safety Science Abstracts KW - aromatic compounds KW - hydrolysis KW - urine KW - occupational health KW - H SI0.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16029876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Analysis+of+urine+to+monitor+exposures+to+benzidine%2C+o-dianisidine%2C+o-tolidine%2C+and+4%2C4%27-methylenedianiline.&rft.au=Neumeister%2C+CE&rft.aulast=Neumeister&rft.aufirst=CE&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - aromatic compounds; hydrolysis; urine; occupational health ER - TY - JOUR T1 - Cost-effective radiator repair ventilation control. AN - 16027387; 2605884 AB - This article describes a cost-effective ventilation enclosure made of a flexible silicon sheet reinforced by fibrous glass that forms a tent-like structure over the water bath that is used to leak test radiators. An opening in the front of the enclosure permits the mechanic to repair the radiator inside the enclosure. A propeller fan mounted in the rear (outside wall) of the enclosure exhausts air at a rate of 3400 m super(3)/hr (2000 cfm), producing an air flow of 1 m/sec (200 fpm) through the enclosure opening. The authors are not aware of any ventilation hood of this type that has previously been designed or installed in radiator repair shops. JF - Applied Occupational & Environmental Hygiene AU - Goldfield, J AU - Sheehy, J W AU - Gunter, B J AU - Daniels, W J AD - Div. Phys. Sci. and Eng., NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 959 EP - 965 VL - 6 IS - 11 SN - 1047-322X, 1047-322X KW - cost benefit analysis KW - radiators KW - repair KW - Health & Safety Science Abstracts KW - ventilation KW - occupational health KW - H SI8.9.3:COLD UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16027387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Cost-effective+radiator+repair+ventilation+control.&rft.au=Goldfield%2C+J%3BSheehy%2C+J+W%3BGunter%2C+B+J%3BDaniels%2C+W+J&rft.aulast=Goldfield&rft.aufirst=J&rft.date=1991-01-01&rft.volume=6&rft.issue=11&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ventilation; occupational health ER - TY - JOUR T1 - Air concentrations of TDI and total reactive isocyanate group in three flexible polyurethane manufacturing facilities. AN - 16020741; 2591005 AB - In-depth industrial hygiene surveys were conducted in two large facilities manufacturing molded flexible foam and one facility manufacturing and finishing flexible slab foam. These surveys were performed to support a retrospective, cohort, mortality study of workers that were potentially exposed to toluene diisocyanate (TDI). The air sample results show that isocyanate concentrations differed from plant to plant and were probably dependent on the operations performed, engineering controls, and the physical layout of the plant. In the two molded foam facilities, many of the personal exposures were above 35 mu g/m super(3), as had been recommended by the National Institute for Occupational Safety and Health (NIOSH). As expected, pouring line workers were generally more exposed than finishing workers. JF - Applied Occupational and Environmental Hygiene AU - Boeniger, M F AD - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 853 EP - 858 VL - 6 IS - 6 SN - 1047-322X, 1047-322X KW - occupational health KW - toluene diisocyanate KW - Health & Safety Science Abstracts; Pollution Abstracts KW - chemical industry KW - surveys KW - air sampling KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI6.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16020741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Air+concentrations+of+TDI+and+total+reactive+isocyanate+group+in+three+flexible+polyurethane+manufacturing+facilities.&rft.au=Boeniger%2C+M+F&rft.aulast=Boeniger&rft.aufirst=M&rft.date=1991-01-01&rft.volume=6&rft.issue=6&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - surveys; air sampling; chemical industry ER - TY - JOUR T1 - Silicosis and lung cancer in North Carolina dusty trades workers. AN - 16014923; 2583037 AB - Since 1940, 760 cases of silicosis have been diagnosed as part of the State of North Carolina's (NC) pneumoconiosis surveillance program for dusty trades workers. Vital status was ascertained through 1983 of 714 cases that had been diagnosed since 1940 and death certificates were obtained for 546 of the 550 deceased. Mortality from tuberculosis, cancer of the intestine and lung, pneumonia, bronchitis, emphysema, asthma, pneumoconiosis, and kidney disease was significantly increased in whites. Mortality from tuberculosis, ischemic heart disease, and pneumoconiosis was significantly increased in non-whites. JF - American Journal of Industrial Medicine AU - Amandus, HE AU - Shy, C AU - Wing, S AU - Blair, A AU - Heineman, E F AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 57 EP - 70 VL - 20 IS - 1 SN - 0271-3586, 0271-3586 KW - lung KW - occupational health KW - North Carolina KW - asbestos KW - foundries KW - respiratory diseases KW - tuberculosis KW - occupational hazards KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - mining KW - USA, North Carolina KW - coal KW - silicosis KW - dust KW - cancer KW - pneumoconiosis KW - X 24240:Miscellaneous KW - H SI2.8.7:DUST KW - H SM10.21:CANCER KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16014923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Silicosis+and+lung+cancer+in+North+Carolina+dusty+trades+workers.&rft.au=Amandus%2C+HE%3BShy%2C+C%3BWing%2C+S%3BBlair%2C+A%3BHeineman%2C+E+F&rft.aulast=Amandus&rft.aufirst=HE&rft.date=1991-01-01&rft.volume=20&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA, North Carolina; cancer; silicosis; asbestos; dust; coal; mining; foundries; pneumoconiosis; respiratory diseases; tuberculosis; occupational hazards ER - TY - PAT T1 - Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds. AN - 16006161; 2578407 AB - A method of treating HIV infection comprises administering about 0.4 to 25.6 mg/kg/day of 2',3'-dideoxyinosine in combination with a member selected from the group consisting of 3'-azido-2',3'-dideoxythymidine, acyclovir, gancyclovir, pentamidine and ribovirin. AU - Yarchoan, R AU - Mitsuya, H AU - Broder, S PY - 1991 IS - US Patent 5,026,687 KW - patents KW - 2',3'-dideoxyinosine KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antiviral agents KW - human immunodeficiency virus KW - acquired immune deficiency syndrome KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16006161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Treatment+of+human+retroviral+infections+with+2%27%2C3%27-dideoxyinosine+alone+and+in+combination+with+other+antiviral+compounds.&rft.au=Yarchoan%2C+R%3BMitsuya%2C+H%3BBroder%2C+S&rft.aulast=Yarchoan&rft.aufirst=R&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/45; Int. Cl. A61K 31/70. N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Studies on three structurally related phenylenediamines with the mouse micronucleus assay system. AN - 15981036; 2551010 AB - Three structurally related compounds, 4-chloro-o-phenylenediamine (COP), 4-nitro-o-phenylenediamine (NOP) and p-phenylenediamine dihydrochloride (PPD), are used in fur dyes, inks and hair coloring formulations. COP has been reported to be carcinogenic in both rats and mice. NOP and PPD are non-carcinogens, but have consistently tested positive in short-term in vitro genotoxicity assays. Studies were undertaken to evaluate their genotoxicity with the in vivo mouse bone-marrow micronucleus assay. Five CD-1 male mice per dose were injected i.p. with the compounds and sacrificed at intervals of 24, 48 and 72 h. 2000 cells were scored per animal to determine the frequency of micronucleated-polychromatic erythrocytes (MPCE). COP induced significant dose-related increases in MPCE over the 3 doses tested at each of the sampling intervals. JF - Mutation Research AU - Soler-Niedziela, L AU - Shi, X AU - Nath, J AU - Ong, T AD - Microbiol. Sect., NIOSH-ALOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 43 EP - 48 VL - 259 IS - 1 SN - 0027-5107, 0027-5107 KW - mice KW - assays KW - systems KW - mutagenicity testing KW - 4-chloro-o-phenylenediamine KW - p-phenylenediamine dihydrochloride KW - 4-nitro-o-phenylenediamine KW - Toxicology Abstracts; Genetics Abstracts KW - micronuclei KW - G 07398:GENERAL KW - X 24155:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15981036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Studies+on+three+structurally+related+phenylenediamines+with+the+mouse+micronucleus+assay+system.&rft.au=Soler-Niedziela%2C+L%3BShi%2C+X%3BNath%2C+J%3BOng%2C+T&rft.aulast=Soler-Niedziela&rft.aufirst=L&rft.date=1991-01-01&rft.volume=259&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - micronuclei ER - TY - JOUR T1 - Pathogenicity of nonstressed, heat-stressed, and resuscitated Listeria monocytogenes 1A1 cells. AN - 15974192; 2545723 AB - The pathogenicity of nonstressed, heat-stressed, and resuscitated cells of Listeria monocytogenes 1A1 was assayed in immunocompromised mice. Cells were stressed by heating them at 56 degree C for 20 min and were resuscitated by incubation in tryptic soy broth at 25 degree C. A dose of 10 super(2) nonstressed and resuscitated cells per mouse was required for pathogenicity; a dose of 10 super(4) heat-stressed cells per mouse was considerably less pathogenic. Loss of hemolytic activity accompanied the decreased virulence. JF - Applied and Environmental Microbiology AU - McCarthy, SA AD - Fish. Res. Branch, FDA, Dauphin Island, AL 36528, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 2389 EP - 2391 VL - 57 IS - 8 SN - 0099-2240, 0099-2240 KW - Listeria monocytogenes KW - effects on KW - pathogenicity KW - mice KW - Microbiology Abstracts B: Bacteriology KW - heat treatments KW - listeriosis KW - bioassays KW - hemolysis KW - immunocompromised hosts KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15974192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Pathogenicity+of+nonstressed%2C+heat-stressed%2C+and+resuscitated+Listeria+monocytogenes+1A1+cells.&rft.au=McCarthy%2C+SA&rft.aulast=McCarthy&rft.aufirst=SA&rft.date=1991-01-01&rft.volume=57&rft.issue=8&rft.spage=2389&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - heat treatments; hemolysis; bioassays; immunocompromised hosts; listeriosis ER - TY - PAT T1 - Probe to identify enteroinvasive E. coli and Shigella species. AN - 15969037; 2535289 AU - Lampel, KA AU - Jagow, JA PY - 1991 IS - US Patent 5,041,372 KW - patents KW - virulence KW - Escherichia coli KW - Shigella KW - nucleotide sequence KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15969037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Probe+to+identify+enteroinvasive+E.+coli+and+Shigella+species.&rft.au=Lampel%2C+KA%3BJagow%2C+JA&rft.aulast=Lampel&rft.aufirst=KA&rft.date=1991-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/6; Int. Cl. C12Q 1/68, 1/24; G01N 33/566; C07H 15/12. N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Statistical evaluation of exposure assessment strategies. AN - 15958557; 2523680 AB - It is well known that exposure measurement error or misclassification can bias an epidemiologic risk assessment. Accordingly, it is useful to have methods of assessing the degree of error in exposure assessments. This paper proposes statistical evaluation techniques for two types of exposure assessment strategies: categorization of exposure and estimation of actual personal exposure levels (with particular attention to the latter). Categorization of exposure is generally done in one of the two ways: ordinal but nonquantitative grouping or quantitative exposure intervals. Estimation of actual exposure levels is most often done in the form of job-by-year exposure matrices and somewhat less often by exposure prediction models. The nature of uncertainty inherent with each of these approaches is described. JF - Applied Occupational & Environmental Hygiene AU - Hornung, R W Y1 - 1991 PY - 1991 DA - 1991 SP - 516 EP - 520 VL - 6 IS - 6 KW - epidemiology KW - Health & Safety Science Abstracts; Pollution Abstracts KW - statistical analysis KW - occupational health KW - risk assessment KW - H SI0.2:DATA ANALYSIS KW - H SM3.3:HAZARD DETERMINATION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15958557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Statistical+evaluation+of+exposure+assessment+strategies.&rft.au=Hornung%2C+R+W&rft.aulast=Hornung&rft.aufirst=R&rft.date=1991-01-01&rft.volume=6&rft.issue=6&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Ventilation control of lead in indoor firing ranges: Inlet configuration and booth and fluctuating flow contributions. AN - 15930880; 2506640 AB - Workers in and, in some cases, users of indoor firing ranges continue to receive overexposures to airborne lead levels in spite of efforts to produce smooth and ample ventilation. Studies of firing ranges by researchers for the National Institute for Occupational Safety and Health (NIOSH) and others have shown that only on very infrequent occasions will the ventilation airflow adequately control lead exposures. Some firing ranges use only ventilation to control lead exposures, and these have stimulated a search for the ventilation system elements that will ensure successful control. Substitution of nonlead bullets and primer as a control means has shown some success but has not gained widespread acceptance because of its effects on the accuracy, range, and reliability of firearms. JF - American Industrial Hygiene Association Journal AU - Crouch, K G AU - Peng, T AU - Murdock, D J AD - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 81 EP - 91 VL - 52 IS - 2 SN - 0002-8894, 0002-8894 KW - ventilation KW - firing ranges KW - monitoring measurements KW - Health & Safety Science Abstracts; Pollution Abstracts KW - lead KW - air quality KW - flow rates KW - indoor environments KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H SI11.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15930880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Ventilation+control+of+lead+in+indoor+firing+ranges%3A+Inlet+configuration+and+booth+and+fluctuating+flow+contributions.&rft.au=Crouch%2C+K+G%3BPeng%2C+T%3BMurdock%2C+D+J&rft.aulast=Crouch&rft.aufirst=K&rft.date=1991-01-01&rft.volume=52&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - indoor environments; lead; air quality; flow rates ER - TY - JOUR T1 - Evaluation of a new solid sorbent sampler for alveolar methylene chloride used in tandem with a bag for sampling alveolar carbon monoxide. AN - 15916867; 2501466 AB - A method for sampling and analysis of methylene chloride and carbon monoxide in alveolar air is described. The method employs a three-section bed of charcoal cloth sorbent for the determination of methylene chloride concentrations and a bag downstream of the solid sorbent sampler for determination of carbon monoxide concentrations. The method was evaluated in a study to assess the level of exposure to and uptake of methylene chloride by 14 furniture strippers. Alveolar breath samples obtained from these workers were analyzed for methylene chloride and carbon monoxide. Venous blood samples also were obtained from the furniture strippers and analyzed for methylene chloride and carboxyhemoglobin. All methylene chloride samples were analyzed by gas chromatography with flame ionization detection. Breath carbon monoxide was analyzed using an electrochemical detector (Ecolyzer). Blood carboxyhemoglobin levels were determined with a CO-Oximeter. JF - Applied Occupational and Environmental Hygiene AU - Glaser, R A AU - Arnold, JE AU - McCammon, CS Jr AU - Phipps, F C AD - NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 380 EP - 388 VL - 6 IS - 5 SN - 1047-322X, 1047-322X KW - carbon monoxide KW - furniture KW - methylene chloride KW - Pollution Abstracts; Health & Safety Science Abstracts KW - blood analysis KW - occupational health KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI1.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15916867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+a+new+solid+sorbent+sampler+for+alveolar+methylene+chloride+used+in+tandem+with+a+bag+for+sampling+alveolar+carbon+monoxide.&rft.au=Glaser%2C+R+A%3BArnold%2C+JE%3BMcCammon%2C+CS+Jr%3BPhipps%2C+F+C&rft.aulast=Glaser&rft.aufirst=R&rft.date=1991-01-01&rft.volume=6&rft.issue=5&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - blood analysis; occupational health ER - TY - JOUR T1 - Role of FDA in establishing tolerable levels for dioxin and PCBs in aquatic organisms. AN - 15915002; 2499386 AB - When fishery products shipped in interstate commerce contain an environmental contaminant that presents a potential threat to public health, the Food and Drug Administration (FDA) undertakes regulatory steps to minimize exposure. These range from seizure of the product to formal rule-making to establish a limit. The basic provision of the Food, Drug, and Cosmetic (FD&C) Act by which the agency deals with environmental contaminants in the food supply is section 402(a)(1), which deals with poisonous and deleterious substances. "Action levels" are administrative guidelines or instructions to the agency field units that define the extent of contamination at which the agency may regard food as adulterated. Except for polychlorinated biphenyls, for which a tolerance is established by regulation, FDA has controlled contaminants in aquatic organisms by using action levels. Under section 406 of the FD&C act, the agency can establish tolerances for unavoidably added poisonous or deleterious substances. This allows the agency to consider the extent to which a contaminant is unavoidable in food while it limits exposure to protect public health. Section 406 requires that the tolerance be established by assessing several factors, including risk. JF - Journal of Toxicology and Environmental Health AU - Boyer, I J AU - Kokoski, CJ AU - Bolger, P M AD - Contam. Team, Stand. and Monit., HFF-156, Branch Div. Toxicol. Rev. and Eval., FDA, 200 C St. SW, Washington, DC 20204, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 93 EP - 101 VL - 33 IS - 1 SN - 0093-4108, 0093-4108 KW - Food and Drug Administration KW - PCB KW - PCB compounds KW - TCDD KW - food contamination KW - government policy KW - human food KW - pollution legislation KW - ASFA 3: Aquatic Pollution & Environmental Quality; Risk Abstracts; Pollution Abstracts; Toxicology Abstracts KW - fishery products KW - legislation KW - standards KW - aquatic organisms KW - seafood KW - X 24120:Food, additives & contaminants KW - R2 23090:Policy and planning KW - X 24230:Legislation & recommended standards KW - P 9000:ENVIRONMENTAL ACTION KW - X 24156:Environmental impact KW - Q5 08505:Prevention and control KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15915002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Role+of+FDA+in+establishing+tolerable+levels+for+dioxin+and+PCBs+in+aquatic+organisms.&rft.au=Boyer%2C+I+J%3BKokoski%2C+CJ%3BBolger%2C+P+M&rft.aulast=Boyer&rft.aufirst=I&rft.date=1991-01-01&rft.volume=33&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - standards; pollution legislation; aquatic organisms; fishery products; seafood; legislation; human food; food contamination; government policy; TCDD; PCB compounds ER - TY - JOUR T1 - Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract. AN - 15909973; 2497444 AB - Human intestinal microbial flora were screened for their abilities to reduce nitroaromatic compounds by growing them on brain heart infusion agar plates containing 1-nitropyrene. Bacteria metabolizing 1-nitropyrene, detected by the appearance of clear zones around the colonies, were identified as Clostridium leptum, Clostridium paraputrificum, Clostridium clostridiiforme , another Clostridium sp., and a Eubacterium sp. These bacteria produced aromatic amines from nitroaromatic compounds, as shown by thin-layer chromatography, high-pressure liquid chromatography, and biochemical tests. Menadione and o-iodosobenzoic acid inhibited nitroreductase activity in all of the isolates, indicating the involvement of sulfhydryl groups in the active site of the enzyme. The optimum pH for nitroreductase activity was 8.0. Only the Clostridium sp. required added flavin adenine dinucleotide for nitroreductase activity. The nitroreductases were constitutive and extracellular. JF - Applied and Environmental Microbiology AU - Rafii, F AU - Franklin, W AU - Heflich, R H AU - Cerniglia, CE AD - Div. Microbiol., Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 962 EP - 968 VL - 57 IS - 4 SN - 0099-2240, 0099-2240 KW - Clostridium KW - activity KW - nitroreductase KW - 1-nitropyrene KW - intestinal microflora KW - nitroaromatic compounds KW - Pollution Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Eubacterium KW - biodegradation KW - enzymes KW - reduction KW - A 01016:Microbial degradation KW - P 6000:TOXICOLOGY AND HEALTH KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15909973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Reduction+of+nitroaromatic+compounds+by+anaerobic+bacteria+isolated+from+the+human+gastrointestinal+tract.&rft.au=Rafii%2C+F%3BFranklin%2C+W%3BHeflich%2C+R+H%3BCerniglia%2C+CE&rft.aulast=Rafii&rft.aufirst=F&rft.date=1991-01-01&rft.volume=57&rft.issue=4&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Eubacterium; reduction; biodegradation; enzymes; intestinal microflora ER - TY - JOUR T1 - Exposure of workers engaged in furniture stripping to methylene chloride as determined by environmental and biological monitoring. AN - 15901940; 2501437 AB - In response to reports of adverse reproductive effects of exposure to methylene chloride, investigators from the National Institute for Occupational Safety and Health conducted an industrial hygiene survey of a cohort of 14 furniture strippers exposed to methylene chloride in five furniture stripping shops. Both environmental and biological monitoring of the workers were conducted. Personal time-weighted average (TWA) concentrations of methylene chloride were determined. Pre- and postshift alveolar breath samples were analyzed for carbon monoxide and methylene chloride. Postshift venous blood samples were analyzed for carboxyhemoglobin and methylene chloride. Methylene chloride TWA exposure of the workers ranged from 15 to 366 ppm, while exposures to other solvents were well below their respective evaluation criteria. The highest average exposures to methylene chloride by job category were strippers (191 ppm) followed by washers (145 ppm) and refinishers (31 ppm). Postexposure breath concentrations of methylene chloride ranged from 2.3 to 167 ppm, while blood concentrations ranged from 0.1 to 8.8 ppm. JF - Applied Occupational and Environmental Hygiene AU - McCammon, CS Jr AU - Glaser, R A AU - Wells, V E AU - Phipps, F C AU - Halperin, W E AD - NIOSH, Denver Reg. Off., Denver, CO, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 371 EP - 379 VL - 6 IS - 5 SN - 1047-322X, 1047-322X KW - methylene chloride KW - furniture KW - biology KW - Pollution Abstracts; Health & Safety Science Abstracts KW - blood analysis KW - occupational health KW - environmental monitoring KW - solvents KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI1.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15901940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+and+Environmental+Hygiene&rft.atitle=Exposure+of+workers+engaged+in+furniture+stripping+to+methylene+chloride+as+determined+by+environmental+and+biological+monitoring.&rft.au=McCammon%2C+CS+Jr%3BGlaser%2C+R+A%3BWells%2C+V+E%3BPhipps%2C+F+C%3BHalperin%2C+W+E&rft.aulast=McCammon&rft.aufirst=CS&rft.date=1991-01-01&rft.volume=6&rft.issue=5&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+and+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - environmental monitoring; solvents; blood analysis; occupational health ER - TY - JOUR T1 - Electromagnetic field exposure and leukemia mortality in the United States. AN - 15901455; 2487768 AB - Reports of excess leukemia mortality or morbidity among men employed in "electrical" occupations who have potential exposures to a wide variety of electromagnetic radiation, including 60 Hz fields, have been described for populations in Washington State 1950 to 1979, California 1959 to 1961, Wisconsin 1963 to 1978, Massachusetts 1971 to 1973, United Kingdom 1970 to 1973, South East England 1961 to 1979, and New Zealand 1979 to 1983. A review article used a meta-analysis to compare 11 epidemiologic reports and found a statistically significant summary relative risk of 1.2 for total leukemias for the 12 electrical occupations. JF - J. OCCUP. MED. AU - Robinson, C F AU - Lalich, N R AU - Burnett, CA AU - Sestito, J P AU - Frazier, T M AD - NIOSH, Mail Stop R-18, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 160 EP - 162 VL - 33 IS - 2 SN - 0096-1736, 0096-1736 KW - electromagnetic radiation KW - man KW - United States KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - electromagnetic fields KW - leukemia KW - occupational exposure KW - USA KW - mortality KW - H SM9.4:ACCIDENT INVESTIGATION KW - X 24210:Radiation & radioactive materials KW - P 8000:RADIATION KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.27:LEUKEMIA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15901455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Electromagnetic+field+exposure+and+leukemia+mortality+in+the+United+States.&rft.au=Robinson%2C+C+F%3BLalich%2C+N+R%3BBurnett%2C+CA%3BSestito%2C+J+P%3BFrazier%2C+T+M&rft.aulast=Robinson&rft.aufirst=C&rft.date=1991-01-01&rft.volume=33&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA; leukemia; occupational exposure; mortality; electromagnetic fields; man ER - TY - JOUR T1 - Limitations in the use of particle size-selective sampling criteria in occupational epidemiology. AN - 15899751; 2472388 AB - The American Conference of Governmental Industrial Hygienists (ACGIH) and the International Standards Organization (ISO) have both recently proposed similar sets of particulate sampling criteria. The criteria describe sample device collection efficiency, as a function of particle size, for inspirable, thoracic, and respirable particulate mass. The collection efficiency curves do not match the lung deposition curves at all particle sizes which leads to a bias between measured particulate (exposure) and deposited particulate (dose). This bias, as a function of particulate size distribution, was examined for both the ACGIH and ISO proposed curves. Results indicate that the amount of bias varies with both geometric mean (mass median aerodynamic diameter) and geometric standard deviation. JF - Applied Occupational & Environmental Hygiene AU - Hewett, P AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 290 EP - 300 VL - 6 IS - 4 SN - 1047-322X, 1047-322X KW - particle size KW - Am. Conf. Gov. Ind. Hyg. KW - dose response effects KW - Health & Safety Science Abstracts; Pollution Abstracts KW - respiration KW - epidemiology KW - occupational health KW - air sampling KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15899751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Occupational+%26+Environmental+Hygiene&rft.atitle=Limitations+in+the+use+of+particle+size-selective+sampling+criteria+in+occupational+epidemiology.&rft.au=Hewett%2C+P&rft.aulast=Hewett&rft.aufirst=P&rft.date=1991-01-01&rft.volume=6&rft.issue=4&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Applied+Occupational+%26+Environmental+Hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; air sampling; respiration; epidemiology ER - TY - JOUR T1 - Evidence for behavioral teratogenicity in humans. AN - 15889891; 2476297 AB - Central to both the scientific development of behavioral teratology and the attention paid to his field as an important area of study is establishing that prenatal exposure of pregnant females to exogenous agents leads to neurobehavioral disorders in their offspring. This tenet may not be questioned by the majority of toxicologists, but others may not be convinced. This paper serves as a brief review of the accumulated evidence that prenatal exposure to a number of drugs and environmental/industrial agents produces behavioral disorders in human infants. JF - Journal of Applied Toxicology AU - Nelson, B K AD - Div. Biomed. and Behav. Sci., NIOSH C-24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 33 EP - 37 VL - 11 IS - 1 SN - 0260-437X, 0260-437X KW - toxicants KW - behaviour KW - Toxicology Abstracts KW - infants KW - teratogenicity KW - man KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15889891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Evidence+for+behavioral+teratogenicity+in+humans.&rft.au=Nelson%2C+B+K&rft.aulast=Nelson&rft.aufirst=B&rft.date=1991-01-01&rft.volume=11&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - teratogenicity; infants; man ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945165 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945112 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945061 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945060 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945058 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945046 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519945030 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519944369 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519944336 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519944289 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519944270 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519944167 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 8 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Diagnostic Interviews for Assessment: Background, Reliability, Validity AN - 1474334580 JF - Alcohol Health and Research World AU - Hasin, Deborah S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 293 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Diagnostic+Interviews+for+Assessment%3A+Background%2C+Reliability%2C+Validity&rft.au=Hasin%2C+Deborah+S&rft.aulast=Hasin&rft.aufirst=Deborah&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Use and Abuse: Some Findings from the National Adolescent Student Health Survey AN - 1474334562 JF - Alcohol Health and Research World AU - Windle, Michael Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Use+and+Abuse%3A+Some+Findings+from+the+National+Adolescent+Student+Health+Survey&rft.au=Windle%2C+Michael&rft.aulast=Windle&rft.aufirst=Michael&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Expectancies and Sexuality AN - 1474334533 JF - Alcohol Health and Research World AU - Goldman, Mark S AU - Roehrich, Laurie Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 126 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Expectancies+and+Sexuality&rft.au=Goldman%2C+Mark+S%3BRoehrich%2C+Laurie&rft.aulast=Goldman&rft.aufirst=Mark&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Finer Points About New Treatment Approaches AN - 1474321944 JF - Alcohol Health and Research World AU - Huey, Elizabeth D Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 219 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Finer+Points+About+New+Treatment+Approaches&rft.au=Huey%2C+Elizabeth+D&rft.aulast=Huey&rft.aufirst=Elizabeth&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - On Defining Alcoholism AN - 1474321816 JF - Alcohol Health and Research World AU - Keller, Mark AU - Doria, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 253 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=On+Defining+Alcoholism&rft.au=Keller%2C+Mark%3BDoria%2C+John&rft.aulast=Keller&rft.aufirst=Mark&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Developing Standardized Measures of Treatment Outcome AN - 1474321754 JF - Alcohol Health and Research World AU - Frawley, P Joseph Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 201 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Developing+Standardized+Measures+of+Treatment+Outcome&rft.au=Frawley%2C+P+Joseph&rft.aulast=Frawley&rft.aufirst=P&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Models of Vulnerability to Psychopathology in Children of Alcoholics: An Overview AN - 1474321728 JF - Alcohol Health and Research World AU - Johnson, Jeannette L AU - Sher, Kenneth J AU - Rolf, Jon E Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 32 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Models+of+Vulnerability+to+Psychopathology+in+Children+of+Alcoholics%3A+An+Overview&rft.au=Johnson%2C+Jeannette+L%3BSher%2C+Kenneth+J%3BRolf%2C+Jon+E&rft.aulast=Johnson&rft.aufirst=Jeannette&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Sexuality and Stigma: The Alcoholic Woman AN - 1474321679 JF - Alcohol Health and Research World AU - Blume, Sheila B Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 139 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Sexuality+and+Stigma%3A+The+Alcoholic+Woman&rft.au=Blume%2C+Sheila+B&rft.aulast=Blume&rft.aufirst=Sheila&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genetic Contributions to Alcoholism Diagnosis AN - 1474321671 JF - Alcohol Health and Research World AU - Pickens, Roy W AU - Svikis, Dace S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 272 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genetic+Contributions+to+Alcoholism+Diagnosis&rft.au=Pickens%2C+Roy+W%3BSvikis%2C+Dace+S&rft.aulast=Pickens&rft.aufirst=Roy&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - OSAP College Drinking Campaign - "Put on the Brakes: Take a Look at College Drinking!" AN - 1474321632 JF - Alcohol Health and Research World AU - Eigen, Lewis D AU - Quinlan, Joan W Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 87 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=OSAP+College+Drinking+Campaign+-+%22Put+on+the+Brakes%3A+Take+a+Look+at+College+Drinking%21%22&rft.au=Eigen%2C+Lewis+D%3BQuinlan%2C+Joan+W&rft.aulast=Eigen&rft.aufirst=Lewis&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Reports The Economic Cost of Alcohol Abuse AN - 1474321583 JF - Alcohol Health and Research World AU - Rice, Dorothy P AU - Kelman, Sander AU - Miller, Leonard S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 307 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Reports+The+Economic+Cost+of+Alcohol+Abuse&rft.au=Rice%2C+Dorothy+P%3BKelman%2C+Sander%3BMiller%2C+Leonard+S&rft.aulast=Rice&rft.aufirst=Dorothy&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Encouraging Collaboration Between Research and Clinical Practice in Alcohol and Other Drug Abuse Treatment AN - 1474321530 JF - Alcohol Health and Research World AU - Woody, George E AU - McLellan, A Thomas AU - Alterman, Arthur A AU - O' Brien, Charles P Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 221 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Encouraging+Collaboration+Between+Research+and+Clinical+Practice+in+Alcohol+and+Other+Drug+Abuse+Treatment&rft.au=Woody%2C+George+E%3BMcLellan%2C+A+Thomas%3BAlterman%2C+Arthur+A%3BO%27+Brien%2C+Charles+P&rft.aulast=Woody&rft.aufirst=George&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Marketing New Ideas About Treatment AN - 1474321526 JF - Alcohol Health and Research World AU - Archer, Loran Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 213 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Marketing+New+Ideas+About+Treatment&rft.au=Archer%2C+Loran&rft.aulast=Archer&rft.aufirst=Loran&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474321512 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 99 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Normal Reproductive System AN - 1474321503 JF - Alcohol Health and Research World AU - Doria, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 101 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Normal+Reproductive+System&rft.au=Doria%2C+John&rft.aulast=Doria&rft.aufirst=John&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - What Is Alcoholism? Current Definitions and Diagnostic Criteria and Their Implications for Treatment AN - 1474321468 JF - Alcohol Health and Research World AU - Flavin, Daniel K AU - Morse, Robert M Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 266 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=What+Is+Alcoholism%3F+Current+Definitions+and+Diagnostic+Criteria+and+Their+Implications+for+Treatment&rft.au=Flavin%2C+Daniel+K%3BMorse%2C+Robert+M&rft.aulast=Flavin&rft.aufirst=Daniel&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Reports Sexuality and Women's Drinking: Findings from a U.S. National Study AN - 1474321463 JF - Alcohol Health and Research World AU - Wilsnack, Sharon C Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 147 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Reports+Sexuality+and+Women%27s+Drinking%3A+Findings+from+a+U.S.+National+Study&rft.au=Wilsnack%2C+Sharon+C&rft.aulast=Wilsnack&rft.aufirst=Sharon&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Relapse Prevention AN - 1474321408 JF - Alcohol Health and Research World AU - Annis, Helen M AU - Davis, Christine S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 204 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Relapse+Prevention&rft.au=Annis%2C+Helen+M%3BDavis%2C+Christine+S&rft.aulast=Annis&rft.aufirst=Helen&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - International Perspectives International Project on Adolescent Drinking AN - 1474321404 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 90 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=International+Perspectives+International+Project+on+Adolescent+Drinking&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 27 Prevalence of DSM - III - R Alcohol Abuse and Dependence: United States, 1988 AN - 1474321269 JF - Alcohol Health and Research World AU - Grant, Bridget F AU - Harford, Thomas C AU - Chou, Patricia AU - Pickering, Roger AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Noble, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 91 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+27+Prevalence+of+DSM+-+III+-+R+Alcohol+Abuse+and+Dependence%3A+United+States%2C+1988&rft.au=Grant%2C+Bridget+F%3BHarford%2C+Thomas+C%3BChou%2C+Patricia%3BPickering%2C+Roger%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BNoble%2C+John&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Practical Concerns for the Use of Assessment Instruments in a Clinical Treatment Setting AN - 1474321261 JF - Alcohol Health and Research World AU - Geller, Anne Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 186 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Practical+Concerns+for+the+Use+of+Assessment+Instruments+in+a+Clinical+Treatment+Setting&rft.au=Geller%2C+Anne&rft.aulast=Geller&rft.aufirst=Anne&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - A Comparison of Diagnostic Criteria: DSM - III - R, Proposed DSM - IV, and Proposed ICD - 10 AN - 1474321248 JF - Alcohol Health and Research World AU - Grant, Bridget F AU - Towle, Leland H Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 284 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=A+Comparison+of+Diagnostic+Criteria%3A+DSM+-+III+-+R%2C+Proposed+DSM+-+IV%2C+and+Proposed+ICD+-+10&rft.au=Grant%2C+Bridget+F%3BTowle%2C+Leland+H&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Interrelationship of Alcoholism Assessment and Treatment AN - 1474321238 JF - Alcohol Health and Research World AU - Allen, John P Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 178 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Interrelationship+of+Alcoholism+Assessment+and+Treatment&rft.au=Allen%2C+John+P&rft.aulast=Allen&rft.aufirst=John&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Early Developmental Factors and Risk for Alcohol Problems AN - 1474321187 JF - Alcohol Health and Research World AU - Zucker, Robert A AU - Fitzgerald, Hiram E Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 18 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Early+Developmental+Factors+and+Risk+for+Alcohol+Problems&rft.au=Zucker%2C+Robert+A%3BFitzgerald%2C+Hiram+E&rft.aulast=Zucker&rft.aufirst=Robert&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genetics of Alcoholism: Can and Should Youth at Risk Be Identified? AN - 1474321156 JF - Alcohol Health and Research World AU - Wilson, James R AU - Crowe, Lawson Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 11 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genetics+of+Alcoholism%3A+Can+and+Should+Youth+at+Risk+Be+Identified%3F&rft.au=Wilson%2C+James+R%3BCrowe%2C+Lawson&rft.aulast=Wilson&rft.aufirst=James&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Monitoring Treatment Outcomes AN - 1474321100 JF - Alcohol Health and Research World AU - Longabaugh, Richard Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 189 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Monitoring+Treatment+Outcomes&rft.au=Longabaugh%2C+Richard&rft.aulast=Longabaugh&rft.aufirst=Richard&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Refining the Link Between Research and Practice AN - 1474317721 JF - Alcohol Health and Research World AU - Caldwell, Fulton Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 175 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Refining+the+Link+Between+Research+and+Practice&rft.au=Caldwell%2C+Fulton&rft.aulast=Caldwell&rft.aufirst=Fulton&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Attention-Deficit Hyperactivity Disorder, Childhood Conduct Disorder, and Alcoholism: Is There an Association? AN - 1474317665 JF - Alcohol Health and Research World AU - Pihl, Robert O AU - Peterson, Jordan B Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 25 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Attention-Deficit+Hyperactivity+Disorder%2C+Childhood+Conduct+Disorder%2C+and+Alcoholism%3A+Is+There+an+Association%3F&rft.au=Pihl%2C+Robert+O%3BPeterson%2C+Jordan+B&rft.aulast=Pihl&rft.aufirst=Robert&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 29 Alcohol Use and Physically Risky Behavior Among Adolescents AN - 1474317641 JF - Alcohol Health and Research World AU - Caces, M Fe AU - Stinson, Frederick S AU - Harford, Thomas C Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 228 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+29+Alcohol+Use+and+Physically+Risky+Behavior+Among+Adolescents&rft.au=Caces%2C+M+Fe%3BStinson%2C+Frederick+S%3BHarford%2C+Thomas+C&rft.aulast=Caces&rft.aufirst=M&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Consumption and Sexual Risk-Taking in Adolescents AN - 1474317639 JF - Alcohol Health and Research World AU - Leigh, Barbara C AU - Morrison, Diane M Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 58 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Consumption+and+Sexual+Risk-Taking+in+Adolescents&rft.au=Leigh%2C+Barbara+C%3BMorrison%2C+Diane+M&rft.aulast=Leigh&rft.aufirst=Barbara&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol, Disinhibition, Sexual Arousal, and Deviant Sexual Behavior AN - 1474317572 JF - Alcohol Health and Research World AU - George, William H AU - Norris, Jeanette Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 133 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol%2C+Disinhibition%2C+Sexual+Arousal%2C+and+Deviant+Sexual+Behavior&rft.au=George%2C+William+H%3BNorris%2C+Jeanette&rft.aulast=George&rft.aufirst=William&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Acculturation and Changes in Drinking Patterns Among Mexican-American Women AN - 1474317559 JF - Alcohol Health and Research World AU - Gilbert, M Jean Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 234 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Acculturation+and+Changes+in+Drinking+Patterns+Among+Mexican-American+Women&rft.au=Gilbert%2C+M+Jean&rft.aulast=Gilbert&rft.aufirst=M&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Effects of Alcohol Abuse on the Health of Adolescents AN - 1474317521 JF - Alcohol Health and Research World AU - Arria, Amelia M AU - Tarter, Ralph E AU - THIEL, DAVID H. VAN Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 52 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Effects+of+Alcohol+Abuse+on+the+Health+of+Adolescents&rft.au=Arria%2C+Amelia+M%3BTarter%2C+Ralph+E%3BTHIEL%2C+DAVID+H.+VAN&rft.aulast=Arria&rft.aufirst=Amelia&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Linking Research with Practice: Common Bonds, Common Progress AN - 1474317515 JF - Alcohol Health and Research World AU - Gordis, Enoch Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 173 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Linking+Research+with+Practice%3A+Common+Bonds%2C+Common+Progress&rft.au=Gordis%2C+Enoch&rft.aulast=Gordis&rft.aufirst=Enoch&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - International Perspectives Initiatives to Curb Alcohol Abuse and Alcoholism in the Former Soviet Union AN - 1474317511 JF - Alcohol Health and Research World AU - Dorman, Nancy D AU - Towle, Leland H Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 303 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=International+Perspectives+Initiatives+to+Curb+Alcohol+Abuse+and+Alcoholism+in+the+Former+Soviet+Union&rft.au=Dorman%2C+Nancy+D%3BTowle%2C+Leland+H&rft.aulast=Dorman&rft.aufirst=Nancy&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474317496 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Fetal Alcohol Effects Among North American Indians AN - 1474317465 JF - Alcohol Health and Research World AU - May, Philip A Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 239 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Fetal+Alcohol+Effects+Among+North+American+Indians&rft.au=May%2C+Philip+A&rft.aulast=May&rft.aufirst=Philip&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Influence of Prenatal Alcohol Exposure on the Process of Neurobehavioral Sexual Differentiation AN - 1474317369 JF - Alcohol Health and Research World AU - McGivern, Robert F AU - Barron, Susan Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 115 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Influence+of+Prenatal+Alcohol+Exposure+on+the+Process+of+Neurobehavioral+Sexual+Differentiation&rft.au=McGivern%2C+Robert+F%3BBarron%2C+Susan&rft.aulast=McGivern&rft.aufirst=Robert&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on the Male Reproductive System AN - 1474317366 JF - Alcohol Health and Research World AU - Wright, Harlan I AU - Gavaler, Judith S AU - Thiel, David Van Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 110 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+the+Male+Reproductive+System&rft.au=Wright%2C+Harlan+I%3BGavaler%2C+Judith+S%3BThiel%2C+David+Van&rft.aulast=Wright&rft.aufirst=Harlan&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - In This Issue - Article Highlights AN - 1474317359 JF - Alcohol Health and Research World Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 171 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=In+This+Issue+-+Article+Highlights&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Nosology of Alcoholism Research AN - 1474317319 JF - Alcohol Health and Research World AU - Beresford, Thomas P Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 260 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Nosology+of+Alcoholism+Research&rft.au=Beresford%2C+Thomas+P&rft.aulast=Beresford&rft.aufirst=Thomas&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Drug Use Screening Inventory: Its Applications in the Evaluation and Treatment of Alcohol and Other Drug Abuse AN - 1474317250 JF - Alcohol Health and Research World AU - Tarter, Ralph E AU - Hegedus, Andrea M Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 65 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Drug+Use+Screening+Inventory%3A+Its+Applications+in+the+Evaluation+and+Treatment+of+Alcohol+and+Other+Drug+Abuse&rft.au=Tarter%2C+Ralph+E%3BHegedus%2C+Andrea+M&rft.aulast=Tarter&rft.aufirst=Ralph&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Special Populations Gay and Alcoholic: Epidemiologic and Clinical Issues AN - 1474317168 JF - Alcohol Health and Research World AU - Paul, Jay P AU - Stall, Ron AU - Bloomfield, Kim A Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 151 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Special+Populations+Gay+and+Alcoholic%3A+Epidemiologic+and+Clinical+Issues&rft.au=Paul%2C+Jay+P%3BStall%2C+Ron%3BBloomfield%2C+Kim+A&rft.aulast=Paul&rft.aufirst=Jay&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Evolution of the DSM Diagnostic Criteria for Alcoholism AN - 1474317167 JF - Alcohol Health and Research World AU - Schuckit, Marc A AU - Nathan, Peter E AU - Helzer, John E AU - Woody, George E AU - Crowley, Tom J Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 278 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Evolution+of+the+DSM+Diagnostic+Criteria+for+Alcoholism&rft.au=Schuckit%2C+Marc+A%3BNathan%2C+Peter+E%3BHelzer%2C+John+E%3BWoody%2C+George+E%3BCrowley%2C+Tom+J&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1991-01-01&rft.volume=15&rft.issue=4&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Just Say Y.E.S.: Matching Adolescents to Appropriate Interventions for Alcohol and Other Drug-Related Problems AN - 1474317156 JF - Alcohol Health and Research World AU - Babor, Thomas F AU - Del Boca, Frances K AU - McLaney, Margaret Anne AU - Jacobi, Barbara AU - Higgins-Biddle, John AU - Hass, William Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 76 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Just+Say+Y.E.S.%3A+Matching+Adolescents+to+Appropriate+Interventions+for+Alcohol+and+Other+Drug-Related+Problems&rft.au=Babor%2C+Thomas+F%3BDel+Boca%2C+Frances+K%3BMcLaney%2C+Margaret+Anne%3BJacobi%2C+Barbara%3BHiggins-Biddle%2C+John%3BHass%2C+William&rft.aulast=Babor&rft.aufirst=Thomas&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 28 Comparative Alcohol-Related Mortality Statistics in the United States by State, 1979-1985 AN - 1474317099 JF - Alcohol Health and Research World AU - Caces, M Fe AU - Stinson, Frederick S AU - Elliott, Steven D AU - Noble, John Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 161 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+28+Comparative+Alcohol-Related+Mortality+Statistics+in+the+United+States+by+State%2C+1979-1985&rft.au=Caces%2C+M+Fe%3BStinson%2C+Frederick+S%3BElliott%2C+Steven+D%3BNoble%2C+John&rft.aulast=Caces&rft.aufirst=M&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on Female Endocrine Function AN - 1474317056 JF - Alcohol Health and Research World AU - Gavaler, Judith S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 104 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+Female+Endocrine+Function&rft.au=Gavaler%2C+Judith+S&rft.aulast=Gavaler&rft.aufirst=Judith&rft.date=1991-01-01&rft.volume=15&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Adolescent Alcohol Decisions AN - 1474316999 JF - Alcohol Health and Research World AU - Fischhoff, Baruch AU - Quadrel, Marilyn Jacobs Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 43 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Adolescent+Alcohol+Decisions&rft.au=Fischhoff%2C+Baruch%3BQuadrel%2C+Marilyn+Jacobs&rft.aulast=Fischhoff&rft.aufirst=Baruch&rft.date=1991-01-01&rft.volume=15&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Promising but Underutilized Treatment Approaches AN - 1474316824 JF - Alcohol Health and Research World AU - McCrady, Barbara S Y1 - 1991/01/01/ PY - 1991 DA - 1991 Jan 01 SP - 215 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 15 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Promising+but+Underutilized+Treatment+Approaches&rft.au=McCrady%2C+Barbara+S&rft.aulast=McCrady&rft.aufirst=Barbara&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Enzyme immunoassay for identification of Vibrio vulnificus in seawater, sediment, and oysters AN - 13740010; S199138334 AB - An enzyme immunoassay (EIA) using Vibrio vulnificus-specific monoclonal antibody (MAb) FRBT37 was used to identify Vibrio vulnificus in enrichment broths and agar cultures of oysters, sediment and seawater. The specificity of MAb FRBT37 was determined by EIA by using 72 laboratory stock strains of bacteria (34 species, 15 genera). There were no cross-reactions. The EIA identified correctly 99.7 per cent of 348 biochemically confirmed V. vulnificus isolates. The epitole corresponding to FRBT37 was found in cells lysed by Triton X-100, deionized water and ultrasonication. It was not found in culture supernatants indicating an intracellular location. Transmission electron micrographs of V. vulnificus labelled with FRBT37-biotin-avidin-gold showed that the epitope reacted with fragments of lysed cells but not whole cells. JF - Applied and Environmental Microbiology AU - Tamplin, M L AU - Martin, AL AU - Ruple, AD AU - Cook, D W AU - Kaspar, C W AD - U.S. Food and Drug Administration, Dauphin Island, Ala. Y1 - 1991 PY - 1991 DA - 1991 SP - 1235 EP - 1240 VL - 57 IS - 4 SN - 0099-2240, 0099-2240 KW - Triton X100 KW - Sea water (see also marine -----) KW - Strain (biological) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13740010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Enzyme+immunoassay+for+identification+of+Vibrio+vulnificus+in+seawater%2C+sediment%2C+and+oysters&rft.au=Tamplin%2C+M+L%3BMartin%2C+AL%3BRuple%2C+AD%3BCook%2C+D+W%3BKaspar%2C+C+W&rft.aulast=Tamplin&rft.aufirst=M&rft.date=1991-01-01&rft.volume=57&rft.issue=4&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Identification of uidA gene sequences in beta-D-glucuronidase-negative Escherichia coli AN - 13736360; 199101720 AB - To study the limitations of the 4-methylumbelliferyl-beta-D-glucuronide (MUG) assay for the identification of Escherichia coli in food and water, a synthetic oligonucleotide probe was directed at the uidA gene of E. coli to examine the distribution of the beta-D-glucuronidase (GUD) enzyme genes in E. coli strains. Of the 116 E. coli isolates examined, 112 hybridized with the probe and 4 MUG-positive E. coli isolates failed to hybridize or were weakly reactive with the probe. Southern hybridizations of DNA from selected isolates showed that the probe reacted with a single 900-bp Hinfl fragment. JF - Applied and Environmental Microbiology AU - Feng, P AU - Lum, R AU - Chang, G W AD - Food and Drug Administration, Washington, D.C. Y1 - 1991 PY - 1991 DA - 1991 SP - 320 EP - 323 VL - 57 IS - 1 SN - 0099-2240, 0099-2240 KW - Enzymes (see also individual groups below) KW - Hybridized KW - Strain (biological) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13736360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Identification+of+uidA+gene+sequences+in+beta-D-glucuronidase-negative+Escherichia+coli&rft.au=Feng%2C+P%3BLum%2C+R%3BChang%2C+G+W&rft.aulast=Feng&rft.aufirst=P&rft.date=1991-01-01&rft.volume=57&rft.issue=1&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Human exposure to polychlorinated biphenyls in Greater New Bedford, Massachusetts: a prevalence study AN - 13729727; 199102839 AB - The serum of individuals aged 18 to 64 years in the community of Greater New Bedford, Mass., was examined to assess the prevalence of elevated levels of polychlorinated biphenyls (PCB). Eight-hundred and forty subjects who had resided in the area for at least 5 years were tested. Despite documented contamination by PCB in the New Bedford area and the common practice of fishing in the harbour for food, the prevalence of elevated serum PCB levels was no higher than in typical unexposed U.S. urban populations. Levels were higher than 30 ppb in only 1.3 per cent of the individuals tested, with similar percentages among men and women. Overall, the prevalence of elevated serum PCB in the local population was assessed as low. There are 30 references. JF - Archives of Environmental Contamination and Toxicology AU - Miller, D T AU - Condon, S K AU - Kutzner, S AU - Phillips, D L AU - Krueger, E AU - Timperi, R AU - Burse, V W AU - Cutler, J AU - Gute, D M AD - U.S. Department of Health and Human Services, Atlanta, Ga. Y1 - 1991 PY - 1991 DA - 1991 SP - 410 EP - 416 VL - 20 IS - 3 SN - 0090-4341, 0090-4341 KW - World health organization KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13729727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Human+exposure+to+polychlorinated+biphenyls+in+Greater+New+Bedford%2C+Massachusetts%3A+a+prevalence+study&rft.au=Miller%2C+D+T%3BCondon%2C+S+K%3BKutzner%2C+S%3BPhillips%2C+D+L%3BKrueger%2C+E%3BTimperi%2C+R%3BBurse%2C+V+W%3BCutler%2C+J%3BGute%2C+D+M&rft.aulast=Miller&rft.aufirst=D&rft.date=1991-01-01&rft.volume=20&rft.issue=3&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Identification of a carboxylic acid metabolite from the catabolism of fluoranthene by a Mycobacterium sp AN - 13722625; S199239375 AB - Mineralization of the high-molecular-weight polycyclic aromatic hydrocarbon fluoranthene by Mycobacterium sp. was investigated using flow-through microcosm test systems containing a carbon-14-labelled culture medium. A carboxylic acid metabolite, isolated by thin layer and high pressure liquid chromatography of the acidified ethyl acetate-extractable fraction, reached a maximal concentration of approximately 0.65 per cent after 24 h incubation. The metabolite was identified as 9-fluoranthene-1-carboxylic acid by comparison with authentic compound using UV and fluorescence spectrophotometry, mass spectral and proton and carbon nuclear magnetic resonance spectral analyses. Mycobacterium sp. initially attacked fluoranthene in the fused aromatic ring portion of the molecule and was potentially useful for bioremediation of PAH. There are 31 references. JF - Applied and Environmental Microbiology AU - Kelly, I AU - Freeman, J P AU - Evans, F E AU - Cerniglia, CE AD - Food and Drug Administration, Jefferson, Ark. Y1 - 1991 PY - 1991 DA - 1991 SP - 636 EP - 641 VL - 57 IS - 3 SN - 0099-2240, 0099-2240 KW - Analysis KW - Fluoranthene KW - Media KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13722625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Identification+of+a+carboxylic+acid+metabolite+from+the+catabolism+of+fluoranthene+by+a+Mycobacterium+sp&rft.au=Kelly%2C+I%3BFreeman%2C+J+P%3BEvans%2C+F+E%3BCerniglia%2C+CE&rft.aulast=Kelly&rft.aufirst=I&rft.date=1991-01-01&rft.volume=57&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Nucleotide sequence of the P34 gene from Rickettsia rickettsii. AN - 20209632; 8735026 JF - Nucleic Acids Research AU - Anderson, B E AU - Baumstark, B R AU - Bellini, W J AD - Division of Viral and Rickettsial Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1990/12/11/ PY - 1990 DA - 1990 Dec 11 SP - 7168 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 18 IS - 23 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Nucleotide sequence KW - Rickettsia rickettsii KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20209632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Nucleotide+sequence+of+the+P34+gene+from+Rickettsia+rickettsii.&rft.au=Anderson%2C+B+E%3BBaumstark%2C+B+R%3BBellini%2C+W+J&rft.aulast=Anderson&rft.aufirst=B&rft.date=1990-12-11&rft.volume=18&rft.issue=23&rft.spage=7168&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Rickettsia rickettsii ER - TY - JOUR T1 - Differential changes in lipid metabolism of myeloid and lymphoid cell lines induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). AN - 80198137; 2125010 AB - Treatment of the myeloid cell lines, U-937 or HL-60, with 10 nM of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), for 24 h increased the rate of incorporation of [3H]glycerol into total chloroform extracts. A proportionally greater labeling of the non-polar lipid (NL) fraction compared to the polar, phospholipid (PL), fraction was observed. Chromatographic analysis showed a 6-fold increase in the labeling of triacylglycerols (TAG), a 2-fold increase in diacylglycerols, and no changes in monoacylglycerols. PL labeling showed a 3-fold increase in phosphatidylcholine (PC). The effect of TPA on TAG labeling was selectively observed in myeloid cell lines. No such a change was found in the lymphoid cell line. MOLT-3, which did respond to TPA with increased PC labeling. Incorporation of [3H]arachidonic acid (AA) into TAG by U-937 cells was selectively increased (2.5-fold) after treatment with TPA for 24 h. Treatment of U-937 cells with TPA in serum-free medium resulted in no increased labeling of TAG. These studies suggest that changes in TAG metabolism may be characteristic of myeloid differentiation and depend on the presence of serum factor(s). JF - FEBS letters AU - Ponzoni, M AU - DeBell, K E AU - Hoffman, T AU - Bonvini, E AD - Laboratory of Cell Biology, DBBP, CBER, US-FDA, Bethesda, MD 20892. Y1 - 1990/12/10/ PY - 1990 DA - 1990 Dec 10 SP - 25 EP - 28 VL - 276 IS - 1-2 SN - 0014-5793, 0014-5793 KW - Arachidonic Acids KW - 0 KW - Glycerides KW - Arachidonic Acid KW - 27YG812J1I KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - Glycerides -- metabolism KW - Lymphoma, Large B-Cell, Diffuse KW - Glycerol -- metabolism KW - Kinetics KW - Humans KW - Leukemia, Promyelocytic, Acute KW - Arachidonic Acids -- metabolism KW - Cell Line KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80198137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Differential+changes+in+lipid+metabolism+of+myeloid+and+lymphoid+cell+lines+induced+by+treatment+with+12-O-tetradecanoylphorbol-13-acetate+%28TPA%29.&rft.au=Ponzoni%2C+M%3BDeBell%2C+K+E%3BHoffman%2C+T%3BBonvini%2C+E&rft.aulast=Ponzoni&rft.aufirst=M&rft.date=1990-12-10&rft.volume=276&rft.issue=1-2&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-14 N1 - Date created - 1991-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Airborne endotoxin concentrations in various work areas within two cotton textile mills in the People's Republic of China. AN - 80343067; 2096849 AB - As part of a multidisciplinary longitudinal approach to assess the roles of airborne cotton dust and endotoxins in affecting the respiratory health of cotton textile workers, this study was designed to quantify the endotoxin contamination of airborne vertically elutriated and total dusts. Yarn preparation areas (opening through fine spinning) were studied at two cotton textile mills which had been studied 5 years previously in Shanghai. People's Republic of China, Filter, with vertically elutriated (VE) or total dusts were mailed to the United States and endotoxin analyses were performed for each filter in duplicate with the quantitative chromogenic modification of the Limulus amebocyte lysate assay. Dusts from all areas of the textile mills contained endotoxins. Endotoxin burdens in VE dusts from the carding area were similar in both milk while the endotoxin contamination of total dust from carding in Mill 1 was over threefold greater than that of total dust from carding in Mill 2. All other areas differed between milk in both VE and total dust endotoxin burdens. Mean endotoxin levels in VE dusts from all areas of both mills were well above the reported threshold of 90 EU/m3 for acute pulmonary function effects in humans. Comparison of selected areas of both mills from the present study with the same work areas from the previous study showed that, in general, the airborne endotoxin burden was higher than levels found 5 years ago in these two mills. The data suggest that even with reduced or unchanged gravimetric dust levels in these two cotton textile mills, airborne endotoxin levels were higher and provided an increased potential for adverse respiratory response in exposed workers. JF - Biomedical and environmental sciences : BES AU - Olenchock, S A AU - Christiani, D C AU - Mull, J C AU - Ye, T T AU - Lu, P L AD - Immunology Section, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 443 EP - 451 VL - 3 IS - 4 SN - 0895-3988, 0895-3988 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Endotoxins KW - Index Medicus KW - Humans KW - Textile Industry KW - China KW - Occupational Exposure KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- toxicity KW - Endotoxins -- analysis KW - Endotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80343067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Airborne+endotoxin+concentrations+in+various+work+areas+within+two+cotton+textile+mills+in+the+People%27s+Republic+of+China.&rft.au=Olenchock%2C+S+A%3BChristiani%2C+D+C%3BMull%2C+J+C%3BYe%2C+T+T%3BLu%2C+P+L&rft.aulast=Olenchock&rft.aufirst=S&rft.date=1990-12-01&rft.volume=3&rft.issue=4&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-19 N1 - Date created - 1991-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral contraceptive oestrogen and progestin potencies and the incidence of deep venous thromboembolism. AN - 80311372; 2084024 AB - To assess possible differences in the incidence of venous thrombosis and pulmonary embolism associated with oral contraceptives of varying hormonal potencies, the authors conducted a retrospective cohort study in the 15-44 year old Michigan Medicaid population. Cohorts were defined by the progestin- and oestrogen-potencies of oral contraceptives in use at the time of follow-up as classified by an oral contraceptive potency scheme. Using the low-oestrogen-/low-progestin-potency formulations for reference (rate ratio = 1), adjusted rate ratios of 0.8 (95% CI: 0.5 to 1.3, P = 0.41) and 0.6 (95% CI 0.4 to 1.2, P = 0.13) were observed for intermediate-progestin-potency and high-progestin-potency formulations, respectively. Adjusted rate ratios of 1.4 (95% CI: 0.8 to 2.3, P = 0.21) and 2.6 (95% CI: 1.2 to 5.5, P = 0.01) were observed for intermediate- and high-oestrogen-potency formulations. These data suggest a dose-response relationship between oral contraceptive oestrogen potency and venous thromboembolism, whereas no such evidence for a dose-response relationship between oral contraceptive progestin potency and venous thrombo-embolism was found. JF - International journal of epidemiology AU - Gerstman, B B AU - Piper, J M AU - Freiman, J P AU - Tomita, D K AU - Kennedy, D L AU - Ferguson, W J AU - Bennett, R C AD - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 931 EP - 936 VL - 19 IS - 4 SN - 0300-5771, 0300-5771 KW - Contraceptives, Oral, Hormonal KW - 0 KW - Estradiol Congeners KW - Progestins KW - Index Medicus KW - Population KW - United States KW - Measurement KW - Drug Interactions KW - Age Factors KW - Research Methodology KW - Physiology KW - Retrospective Studies KW - Medical Assistance, Title 19 KW - Oral Contraceptives KW - Aged KW - Contraceptive Methods KW - Treatment KW - Hormones KW - Developed Countries KW - Thromboembolism KW - Progesterone--analysis KW - Population Characteristics KW - Financial Activities KW - Public Assistance KW - Adult KW - Demographic Factors KW - Diseases KW - Family Planning KW - Drugs KW - North America KW - Americas KW - Estrogens--analysis KW - Vascular Diseases KW - Endocrine System KW - Studies KW - Cohort Analysis KW - Economic Factors KW - Financing, Government KW - Northern America KW - Progestational Hormones KW - Contraception KW - Embolism KW - Risk Factors KW - Incidence KW - Michigan KW - Biology KW - Humans KW - Cohort Studies KW - Adolescent KW - Michigan -- epidemiology KW - Female KW - Estradiol Congeners -- adverse effects KW - Thrombophlebitis -- epidemiology KW - Thrombophlebitis -- chemically induced KW - Progestins -- adverse effects KW - Progestins -- administration & dosage KW - Estradiol Congeners -- administration & dosage KW - Contraceptives, Oral, Hormonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80311372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Oral+contraceptive+oestrogen+and+progestin+potencies+and+the+incidence+of+deep+venous+thromboembolism.&rft.au=Gerstman%2C+B+B%3BPiper%2C+J+M%3BFreiman%2C+J+P%3BTomita%2C+D+K%3BKennedy%2C+D+L%3BFerguson%2C+W+J%3BBennett%2C+R+C&rft.aulast=Gerstman&rft.aufirst=B&rft.date=1990-12-01&rft.volume=19&rft.issue=4&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-15 N1 - Date created - 1991-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Epidemiol. 1992 Apr;21(2):420-1 [1428500] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Study of the teratogenic potential of FD & C Yellow No. 5 when given by gavage to rats. AN - 80224832; 2276704 AB - FD & C Yellow No. 5 (tartrazine) was given to Osborne-Mendel rats by gavage at dose levels of 0, 60, 100, 200, 400, 600 or 1000 mg/kg body weight/day on days 0-19 of gestation. No maternal or developmental toxicity was observed when the rats were killed on day 20. The mean daily food consumption for the entire period of gestation was significantly greater in the females given 1000 mg/kg body weight/day than in the controls, but maternal body-weight gain was not affected. No dose-related effects were observed in implantations, foetal viability or external foetal development. Foetal skeletal and visceral development was similar among foetuses from all groups. At the doses given, FD & C Yellow No. 5 was neither toxic nor teratogenic. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Collins, T F AU - Black, T N AU - Brown, L H AU - Bulhack, P AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 821 EP - 827 VL - 28 IS - 12 SN - 0278-6915, 0278-6915 KW - Tartrazine KW - I753WB2F1M KW - Index Medicus KW - Rats KW - Eating -- drug effects KW - Administration, Oral KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Male KW - Female KW - Abnormalities, Drug-Induced KW - Pregnancy -- drug effects KW - Tartrazine -- administration & dosage KW - Tartrazine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80224832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Study+of+the+teratogenic+potential+of+FD+%26amp%3B+C+Yellow+No.+5+when+given+by+gavage+to+rats.&rft.au=Collins%2C+T+F%3BBlack%2C+T+N%3BBrown%2C+L+H%3BBulhack%2C+P&rft.aulast=Collins&rft.aufirst=T&rft.date=1990-12-01&rft.volume=28&rft.issue=12&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-01 N1 - Date created - 1991-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of mononitrodihydrobenzo[a]pyrenes. AN - 80199749; 2266979 JF - Mutation research AU - Fu, P P AU - Jung, H AU - Von Tungeln, L S AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 277 EP - 285 VL - 245 IS - 4 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Nitro Compounds KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Molecular Structure KW - Mutagenicity Tests KW - Salmonella typhimurium -- growth & development KW - Salmonella typhimurium -- genetics KW - Nitro Compounds -- toxicity KW - Benzo(a)pyrene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80199749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutagenicity+of+mononitrodihydrobenzo%5Ba%5Dpyrenes.&rft.au=Fu%2C+P+P%3BJung%2C+H%3BVon+Tungeln%2C+L+S%3BHeflich%2C+R+H&rft.aulast=Fu&rft.aufirst=P&rft.date=1990-12-01&rft.volume=245&rft.issue=4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-14 N1 - Date created - 1991-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of liver, kidney, and erythrocyte delta-aminolevulinic acid dehydratase (porphobilinogen synthase) by gallium in the rat. AN - 80164386; 2253599 AB - Selective inhibition of enzymes in the heme biosynthesis pathway with concomitant urinary excretion of heme precursors serve as potentially important biological markers of chemical exposure and cell injury. Intratracheal administration of gallium arsenide particulate suspensions has been shown to result in inhibition of delta-aminolevulinic acid dehydratase (ALAD) in several tissues and increased excretion of the heme precursor aminolevulinic acid (ALA). This study was undertaken to evaluate in vivo the role of gallium alone in ALAD inhibition and increased urinary excretion of ALA. Male CD rats received a single ip injection of Ga2(SO4)3 at doses of 12.5, 25, 50, 100, and 200 mg Ga/kg. A dose-dependent inhibition of ALAD was observed 24 hr later in liver, kidney, and erythrocytes. After injection of 25 mg Ga/kg, maximal inhibition (42 to 49% of control) of ALAD occurred between 6 and 24 hr in liver and kidney with full recovery of activity at 96 hr. In erythrocytes, maximal inhibition (48% of control) occurred between 24 and 48 hr with recovery of activity at 96 hr. Mild to moderate renal proximal tubular necrosis in the pars recta was observed 24 hr after administration of 100 and 200 mg/kg, but no histopathologic changes were evident at lower doses. No consistent changes in urinary excretion of ALA were observed. Lineweaver-Burk analyses of renal and hepatic ALAD activities in the absence and presence of gallium indicated that the inhibition of ALAD by this element is noncompetitive (same Km, decreased Vmax). Gallium was shown to possess an inhibition constant (Ki) of approximately 3 microns for ALAD, similar to the Ki obtained for lead in other studies. Incubation of ALAD in vitro with gallium and lead, an active thiol group inhibitor, resulted in a greater inhibition of the enzyme. Further in vitro studies demonstrated the attenuation of gallium inhibition of hepatic and renal ALAD by zinc, suggesting that the mechanism of gallium action may involve competition for or displacement of zinc from the sulfhydryl group of the enzyme active site. Since ALAD inhibition occurred at doses at which no histopathologic changes were evident, the determination of ALAD activity in various tissues, including blood, may be of potential value as a biomarker of exposure/toxicity to metals such as gallium. The effect of chemical form and route of exposure of gallium and effects of other Group III metals on inhibition of ALAD and excretion of ALA is discussed.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Environmental research AU - Goering, P L AU - Rehm, S AD - Division of Life Science, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 135 EP - 151 VL - 53 IS - 2 SN - 0013-9351, 0013-9351 KW - Lead KW - 2P299V784P KW - Gallium KW - CH46OC8YV4 KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Zinc -- pharmacology KW - Drug Interactions KW - Kinetics KW - Lead -- pharmacology KW - Male KW - Porphobilinogen Synthase -- antagonists & inhibitors KW - Erythrocytes -- drug effects KW - Liver -- enzymology KW - Erythrocytes -- enzymology KW - Gallium -- pharmacology KW - Liver -- drug effects KW - Kidney -- enzymology KW - Kidney -- drug effects KW - Porphobilinogen Synthase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80164386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Inhibition+of+liver%2C+kidney%2C+and+erythrocyte+delta-aminolevulinic+acid+dehydratase+%28porphobilinogen+synthase%29+by+gallium+in+the+rat.&rft.au=Goering%2C+P+L%3BRehm%2C+S&rft.aulast=Goering&rft.aufirst=P&rft.date=1990-12-01&rft.volume=53&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-22 N1 - Date created - 1991-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - US food legislation. AN - 80162134; 1979377 JF - Lancet (London, England) AU - Thompson, P AU - Salsbury, P A AU - Adams, C AU - Archer, D L AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. PY - 1990 SP - 1557 EP - 1559 VL - 336 IS - 8730 SN - 0140-6736, 0140-6736 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Food Contamination -- prevention & control KW - Food Microbiology -- standards KW - Food Contamination -- legislation & jurisprudence KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80162134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=US+food+legislation.&rft.au=Thompson%2C+P%3BSalsbury%2C+P+A%3BAdams%2C+C%3BArcher%2C+D+L&rft.aulast=Thompson&rft.aufirst=P&rft.date=1990-12-01&rft.volume=336&rft.issue=8730&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=01406736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-24 N1 - Date created - 1991-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seafood safety. AN - 80135564; 2244553 JF - American family physician AU - Nightingale, S L AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1657 EP - 1658 VL - 42 IS - 6 SN - 0002-838X, 0002-838X KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Fishes -- microbiology KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Food Microbiology KW - Fish Products -- standards KW - Shellfish -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80135564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Seafood+safety.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1990-12-01&rft.volume=42&rft.issue=6&rft.spage=1657&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-03 N1 - Date created - 1991-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of tetanus toxin on oxytocin and vasopressin release from nerve endings of the neurohypophysis. AN - 80087932; 2172468 AB - The effect of tetanus toxin on neuropeptide hormone release from isolated nerve endings of the neural lobe of rat pituitaries (neurosecretosomes) was measured in a perfusion system. Tetanus toxin inhibited depolarization-evoked release of oxytocin and vasopressin in a time- and dose-dependent manner. At 1 microgram/ml, tetanus toxin blocked stimulated release by 85%. Tetanus toxin that was preincubated with a neutralizing monoclonal antibody or heated to 100 degrees C had no effect on hormone release. The ionophores A23187 and ionomycin were potent stimulators of hormone release in control nerve endings, but were not able to overcome the effect of tetanus toxin in intoxicated nerve endings. 8-Bromo-cyclic GMP, which has been reported to reverse the action of tetanus toxin in PC12 cells, had no effect on the action of tetanus toxin in neurosecretosomes. Neurosecretosomes are the first system in which tetanus toxin has been shown to block release from peptidergic nerve terminals. They appear to be a valuable in vitro system for studying the biochemical mechanism of tetanus toxin action. JF - Journal of neurochemistry AU - Halpern, J L AU - Habig, W H AU - Trenchard, H AU - Russell, J T AD - Division of Bacterial Products, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 2072 EP - 2078 VL - 55 IS - 6 SN - 0022-3042, 0022-3042 KW - Tetanus Toxin KW - 0 KW - Vasopressins KW - 11000-17-2 KW - 8-bromocyclic GMP KW - 31356-94-2 KW - Calcimycin KW - 37H9VM9WZL KW - Oxytocin KW - 50-56-6 KW - Ionomycin KW - 56092-81-0 KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Osmolar Concentration KW - Animals KW - Cyclic GMP -- pharmacology KW - Ionomycin -- pharmacology KW - Calcimycin -- pharmacology KW - Time Factors KW - Male KW - Cyclic GMP -- analogs & derivatives KW - Nerve Endings -- metabolism KW - Vasopressins -- metabolism KW - Oxytocin -- antagonists & inhibitors KW - Vasopressins -- antagonists & inhibitors KW - Oxytocin -- metabolism KW - Pituitary Gland, Posterior -- metabolism KW - Tetanus Toxin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80087932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Effect+of+tetanus+toxin+on+oxytocin+and+vasopressin+release+from+nerve+endings+of+the+neurohypophysis.&rft.au=Halpern%2C+J+L%3BHabig%2C+W+H%3BTrenchard%2C+H%3BRussell%2C+J+T&rft.aulast=Halpern&rft.aufirst=J&rft.date=1990-12-01&rft.volume=55&rft.issue=6&rft.spage=2072&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-20 N1 - Date created - 1990-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Application of multidimensional gas chromatography-mass spectrometry to the determination of glycol ethers in air. AN - 80312432; 2081755 AB - The applicability of multidimensional gas chromatography-mass spectrometry to the analysis of five glycol ethers in air was demonstrated. Air samples were collected on charcoal tubes and desorbed with 5% methanol in methylene chloride as is described in method 1403 of the National Institute for Occupational Safety and Health Manual of Analytical Methods. The glycol ethers were determined by multidimensional gas chromatography-mass spectrometry. The limit of detection was 5 to 7 micrograms/sample for each compound. JF - Journal of chromatography AU - Kennedy, E R AU - O'Connor, P F AU - Grote, A A AD - Inorganic Methods Development Section, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/11/28/ PY - 1990 DA - 1990 Nov 28 SP - 303 EP - 313 VL - 522 KW - Air Pollutants, Occupational KW - 0 KW - Ethylene Glycols KW - Methyl Ethers KW - Propylene Glycols KW - Charcoal KW - 16291-96-6 KW - dipropylene glycol monomethyl ether KW - 34590-94-8 KW - n-butoxy-2-propanol KW - 5131-66-8 KW - butyl carbitol KW - 9TB90IYC0E KW - n-butoxyethanol KW - I0P9XEZ9WV KW - Index Medicus KW - Propylene Glycols -- analysis KW - Methyl Ethers -- analysis KW - Gas Chromatography-Mass Spectrometry -- methods KW - Air Pollutants, Occupational -- analysis KW - Ethylene Glycols -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80312432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography&rft.atitle=Application+of+multidimensional+gas+chromatography-mass+spectrometry+to+the+determination+of+glycol+ethers+in+air.&rft.au=Kennedy%2C+E+R%3BO%27Connor%2C+P+F%3BGrote%2C+A+A&rft.aulast=Kennedy&rft.aufirst=E&rft.date=1990-11-28&rft.volume=522&rft.issue=&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-07 N1 - Date created - 1991-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - NIOSH method 7402--asbestos fibers (Revision #1)--low-temperature ashing of filter samples. AN - 80313359; 2085160 JF - American Industrial Hygiene Association journal AU - Baron, P A AU - Platek, S F AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - A730 EP - A731 VL - 51 IS - 11 SN - 0002-8894, 0002-8894 KW - Air Pollutants KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Electron Probe Microanalysis KW - Particle Size KW - Microscopy, Electron KW - Cold Temperature KW - Air Pollutants -- analysis KW - Microscopy, Electron, Scanning KW - Asbestos -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80313359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=NIOSH+method+7402--asbestos+fibers+%28Revision+%231%29--low-temperature+ashing+of+filter+samples.&rft.au=Baron%2C+P+A%3BPlatek%2C+S+F&rft.aulast=Baron&rft.aufirst=P&rft.date=1990-11-01&rft.volume=51&rft.issue=11&rft.spage=A730&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-10 N1 - Date created - 1991-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Migration into food of polyethylene terephthalate (PET) cyclic oligomers from PET microwave susceptor packaging. AN - 80293124; 2150379 AB - A quantitative method has been developed to measure the migration of polyethylene terephthalate (PET) cyclic oligomers from aluminized PET susceptor film-type food packaging into several food types. Microwaveable French fries, popcorn, fish sticks, waffles and pizza sold in susceptor-type packaging were purchased in local markets, cooked according to package instructions and analysed for PET oligomers. Appropriate food blanks were cooked in glass containers. Quantities of PET oligomers found in the foods ranged from less than 0.012 micrograms/g to approximately 7 micrograms/g. JF - Food additives and contaminants AU - Begley, T H AU - Dennison, J L AU - Hollifield, H C AD - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204. PY - 1990 SP - 797 EP - 803 VL - 7 IS - 6 SN - 0265-203X, 0265-203X KW - Polyethylene Terephthalates KW - 0 KW - Index Medicus KW - Cooking KW - Chromatography, High Pressure Liquid KW - Hot Temperature KW - Microwaves KW - Food Contamination -- analysis KW - Cooking and Eating Utensils KW - Polyethylene Terephthalates -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80293124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Migration+into+food+of+polyethylene+terephthalate+%28PET%29+cyclic+oligomers+from+PET+microwave+susceptor+packaging.&rft.au=Begley%2C+T+H%3BDennison%2C+J+L%3BHollifield%2C+H+C&rft.aulast=Begley&rft.aufirst=T&rft.date=1990-11-01&rft.volume=7&rft.issue=6&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-29 N1 - Date created - 1991-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A displacement pump procedure to load extracts for automated gel permeation chromatography. AN - 80265248; 2289932 AB - Automated gel permeation chromatography (GPC) effectively separates lipids from pesticides in sample extracts that contain fat. Using a large syringe to load sample extracts manually onto GPC models having 5 mL holding loops is awkward, slow, and potentially hazardous. Loading with a small-volume displacement pump, however, is convenient and fast (ca 1 loop every 20 s). And more importantly, the analyst is not exposed to toxic organic vapors because the loading pump and its connecting lines do not leak in the way that a syringe does. JF - Journal - Association of Official Analytical Chemists AU - Daft, J AU - Hopper, M AU - Hensley, D AU - Sisk, R AD - Food and Drug Administration, Department of Health and Human Services, Kansas City District Office, MO 64106. PY - 1990 SP - 992 EP - 994 VL - 73 IS - 6 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - Food Contamination -- analysis KW - Pesticide Residues -- analysis KW - Autoanalysis -- instrumentation KW - Specimen Handling -- instrumentation KW - Chromatography, Gel -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80265248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=A+displacement+pump+procedure+to+load+extracts+for+automated+gel+permeation+chromatography.&rft.au=Daft%2C+J%3BHopper%2C+M%3BHensley%2C+D%3BSisk%2C+R&rft.aulast=Daft&rft.aufirst=J&rft.date=1990-11-01&rft.volume=73&rft.issue=6&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-03 N1 - Date created - 1991-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of gentian violet, its demethylated metabolites, and leucogentian violet in chicken tissue by liquid chromatography with electrochemical detection. AN - 80261760; 2289926 AB - A method is presented for determination of residues of gentian violet (GV), its demethylated metabolites (pentamethyl and tetramethyl), and leucogentian violet (LGV) in chicken tissue. The analytes are extracted from tissue with acetonitrile/buffer and partitioned into methylene chloride. Polar lipids are removed on an alumina column followed by partitioning into methylene chloride from a citrate buffer. The compounds of interest are isolated on a disposable carboxylic acid cation exchange column and then eluted with 0.02% HCl in methanol. GV, its metabolites, and LGV are determined by liquid chromatography using isocratic elution with a buffered mobile phase from a cyano column and amperometric electrochemical detection at +1.000 V. Average recoveries of GV and LGV from commercially purchased chicken liver fortified with 20 ppb of each compound were 92% [standard deviation (SD) = 7, coefficient of variation (CV) = 7.6%] and 86% (SD = 7, CV = 8.1%), respectively. Average recoveries of GV, LGV, the pentamethyl metabolite, and 1 of the tetramethyl metabolites from control chicken liver (provided by the Center for Veterinary Medicine) fortified with 20 ppb of each compound were 80% (SD = 7, CV = 8.8%), 76% (SD = 3, CV = 3.9%), 83% (SD = 6, CV = 7.2%), and 76% (SD = 8, CV = 10.5%), respectively. Mean results from 10 analyses of residue-incurred chicken liver were 31 ppb GV (SD = 3, CV = 9.7%), 34 ppb pentamethyl metabolite (SD = 3, CV = 8.8%), and 40 ppb tetramethyl metabolite(s) (SD = 2, CV = 5.0%), for an average value of 105 ppb total residues (SD = 6, CV = 5.7%); no LGV was found. Data are also presented to show applicability of the method to muscle tissue. JF - Journal - Association of Official Analytical Chemists AU - Roybal, J E AU - Munns, R K AU - Hurlbut, J A AU - Shimoda, W AD - Food and Drug Administration, Denver Federal Center, CO 80225-0087. PY - 1990 SP - 940 EP - 946 VL - 73 IS - 6 SN - 0004-5756, 0004-5756 KW - leucogentian violet KW - 603-48-5 KW - Gentian Violet KW - J4Z741D6O5 KW - Aluminum Oxide KW - LMI26O6933 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Muscles -- chemistry KW - Chromatography, Liquid -- methods KW - Reference Standards KW - Electrochemistry KW - Methylation KW - Liver -- chemistry KW - Drug Residues -- analysis KW - Food Contamination -- analysis KW - Meat -- analysis KW - Gentian Violet -- analysis KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80261760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Determination+of+gentian+violet%2C+its+demethylated+metabolites%2C+and+leucogentian+violet+in+chicken+tissue+by+liquid+chromatography+with+electrochemical+detection.&rft.au=Roybal%2C+J+E%3BMunns%2C+R+K%3BHurlbut%2C+J+A%3BShimoda%2C+W&rft.aulast=Roybal&rft.aufirst=J&rft.date=1990-11-01&rft.volume=73&rft.issue=6&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-03 N1 - Date created - 1991-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Liquid chromatographic determination of multiple sulfonamide residues in bovine milk. AN - 80261715; 2289918 AB - A liquid chromatographic method has been developed for simultaneous determination of residues of 10 sulfonamide drugs at 10 ppb and above in raw bovine milk. The method is based on a chloroform-acetone extraction, evaporation of organic phase, dissolution of residues in an aqueous potassium phosphate solution, and extraction of fatty residue into hexane. The aqueous layer is collected, filtered, injected onto an LC system, and detected by ultraviolet absorption at 265 nm. To elute all 10 sulfonamides isocratically, 2 chromatographic conditions are required. Seven sulfonamides can be quantitated with 12% methanol in the mobile phase; 4 sulfonamides can be quantitated with 30% methanol. Sulfamethazine, the most widely used sulfonamide, is detected on both systems. Recoveries are 44-87% for individual sulfonamides, with only 2 below 60%. Coefficients of variation are 3-13% at 10 ppb. JF - Journal - Association of Official Analytical Chemists AU - Smedley, M D AU - Weber, J D AD - Food and Drug Administration, Center for Veterinary Medicine, Beltsville, MD 20705. PY - 1990 SP - 875 EP - 879 VL - 73 IS - 6 SN - 0004-5756, 0004-5756 KW - Sulfonamides KW - 0 KW - Index Medicus KW - Animals KW - Cattle KW - Reference Standards KW - Chromatography, Liquid KW - Sulfonamides -- analysis KW - Drug Residues -- analysis KW - Food Contamination -- analysis KW - Milk -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80261715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Liquid+chromatographic+determination+of+multiple+sulfonamide+residues+in+bovine+milk.&rft.au=Smedley%2C+M+D%3BWeber%2C+J+D&rft.aulast=Smedley&rft.aufirst=M&rft.date=1990-11-01&rft.volume=73&rft.issue=6&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-03 N1 - Date created - 1991-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidemiologic typing of Enterobacter sakazakii in two neonatal nosocomial outbreaks. AN - 80236546; 2279379 AB - Two unrelated hospital outbreaks of Enterobacter sakazakii, involving meningitis, bacteremia, and colonization of neonates, were investigated. In each of these outbreaks, E. sakazakii was isolated from both patients and dried infant formula. In previous outbreaks, the source and mode of transmission of E. sakazakii in neonatal infections was not determined. In this study, we used a combination of typing methods (plasmid analysis, antibiograms, chromosomal restriction endonuclease analysis, ribotyping, and multilocus enzyme electrophoresis) to evaluate the isolates from each outbreak as to their relatedness. The typing results differed among outbreaks, but in each one, patient and formula isolates shared the same typing pattern. The only exceptions were disk antibiograms, which often varied among colonies selected from each of the isolates. Plasmid analysis, chromosomal restriction endonuclease analysis, ribotyping, and multilocus enzyme electrophoresis all were effective as epidemiological typing methods for E. sakazakii, especially when used in combination. By using this typing scheme, we have confirmed that E. sakazakii from intrinsically contaminated dried infant formula was the source of neonatal infection. JF - Diagnostic microbiology and infectious disease AU - Clark, N C AU - Hill, B C AU - O'Hara, C M AU - Steingrimsson, O AU - Cooksey, R C AD - Antimicrobics Investigations Branch, Center for Infectious Diseases, U.S. Public Health Service, Atlanta, Georgia 30333. PY - 1990 SP - 467 EP - 472 VL - 13 IS - 6 SN - 0732-8893, 0732-8893 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Enzymes KW - Index Medicus KW - Enzymes -- analysis KW - Humans KW - Restriction Mapping KW - Infant, Newborn KW - Anti-Bacterial Agents -- pharmacology KW - Infant Food KW - Plasmids KW - DNA, Bacterial -- analysis KW - Enterobacter -- drug effects KW - Food Microbiology KW - Enterobacteriaceae Infections -- microbiology KW - Enterobacter -- enzymology KW - Enterobacter -- classification KW - Enterobacter -- genetics KW - Cross Infection -- microbiology KW - Cross Infection -- epidemiology KW - Enterobacteriaceae Infections -- epidemiology KW - Disease Outbreaks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80236546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+microbiology+and+infectious+disease&rft.atitle=Epidemiologic+typing+of+Enterobacter+sakazakii+in+two+neonatal+nosocomial+outbreaks.&rft.au=Clark%2C+N+C%3BHill%2C+B+C%3BO%27Hara%2C+C+M%3BSteingrimsson%2C+O%3BCooksey%2C+R+C&rft.aulast=Clark&rft.aufirst=N&rft.date=1990-11-01&rft.volume=13&rft.issue=6&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Diagnostic+microbiology+and+infectious+disease&rft.issn=07328893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-14 N1 - Date created - 1991-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An evaluation of preservative adsorption onto nylon membrane filters. AN - 80229606; 2277319 AB - Pharmaceutical drug products often contain antimicrobial agents as a preservative in their formulation. These excipients are required to destroy or impede the growth of microorganisms that inadvertently enter the product during manufacturing. Unfortunately, these preservatives may also interfere with microbiological assays used to determine product sterility or bioburden levels. The extent of interference by these preservatives can be quite significant, but varies depending on the method used. The most frequently used method for testing parenteral drug products is the membrane filtration technique. Membrane filters are composed of a wide variety of materials such as cellulose, polycarbonate, acrylic polypropylene, Teflon, and nylon. This study evaluated the adsorption characteristics that nylon filters, obtained from five different manufacturers, had on the filtration of solutions of four different antimicrobial compounds (phenol, methylparaben, propylparaben, and benzalkonium chloride). The adsorption properties were determined using both HPLC and microbiological assay techniques. The data revealed that there was a wide range in the amounts of antimicrobial agent (2.3 to 94.1%) bound to the membrane filters when direct product filtration was used without a subsequent rinse step. However, when a rinse step is included, only propylparaben showed any significant "true" adsorption (less than 1 to 33.3%), but showed only marginal bacterial inhibition. Interestingly, the microbiological assays indicated that with a saline rinse step, only benzalkonium chloride was lethal for the two challenge organisms even though the percent adsorbed as measured by HPLC was below 1%. This discrepancy is significant because it demonstrates the analytical limitation when using HPLC to detect minimal concentrations of benzalkonium chloride that may be deleterious to microorganisms.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of parenteral science and technology : a publication of the Parenteral Drug Association AU - Guilfoyle, D E AU - Roos, R AU - Carito, S L AD - Food and Drug Administration, Department of Health and Human Services, Brooklyn, New York. PY - 1990 SP - 314 EP - 319 VL - 44 IS - 6 SN - 0279-7976, 0279-7976 KW - Nylons KW - 0 KW - Preservatives, Pharmaceutical KW - Index Medicus KW - Adsorption KW - Environmental Monitoring -- methods KW - Chromatography, High Pressure Liquid KW - Preservatives, Pharmaceutical -- chemistry KW - Filtration KW - Drug Contamination -- prevention & control KW - Quality Control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80229606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+parenteral+science+and+technology+%3A+a+publication+of+the+Parenteral+Drug+Association&rft.atitle=An+evaluation+of+preservative+adsorption+onto+nylon+membrane+filters.&rft.au=Guilfoyle%2C+D+E%3BRoos%2C+R%3BCarito%2C+S+L&rft.aulast=Guilfoyle&rft.aufirst=D&rft.date=1990-11-01&rft.volume=44&rft.issue=6&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Journal+of+parenteral+science+and+technology+%3A+a+publication+of+the+Parenteral+Drug+Association&rft.issn=02797976&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-05 N1 - Date created - 1991-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - New developments in the Life Table Analysis System of the National Institute for Occupational Safety and Health. AN - 80169781; 2258764 AB - In the 1970s, the National Institute for Occupational Safety and Health developed a Life Table Analysis System to analyze occupational cohort studies. We have updated the original system by adding two new features: direct standardization with a test for linear trend, and analyses by lagged exposure (either duration of exposure or cumulative exposure). We have also updated US reference rates through 1989. The updated systems and documentation (version F) are available upon request. In collaboration with the National Cancer Institute, we have also developed multiple cause-of-death rate files, which consider contributory as well as underlying cause. These files (also available upon request) will enable investigators to derive the expected prevalence of diseases at death, which can then be compared with the observed prevalence in an exposed cohort. Work is currently underway to produce a personal computer version of the Life Table Analysis System. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Steenland, K AU - Beaumont, J AU - Spaeth, S AU - Brown, D AU - Okun, A AU - Jurcenko, L AU - Ryan, B AU - Phillips, S AU - Roscoe, R AU - Stayner, L AD - Industry-Wide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1091 EP - 1098 VL - 32 IS - 11 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - United States KW - Software KW - Microcomputers KW - Humans KW - National Institutes of Health (U.S.) KW - Cohort Studies KW - Data Interpretation, Statistical KW - Cause of Death KW - Prevalence KW - Life Tables KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80169781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=New+developments+in+the+Life+Table+Analysis+System+of+the+National+Institute+for+Occupational+Safety+and+Health.&rft.au=Steenland%2C+K%3BBeaumont%2C+J%3BSpaeth%2C+S%3BBrown%2C+D%3BOkun%2C+A%3BJurcenko%2C+L%3BRyan%2C+B%3BPhillips%2C+S%3BRoscoe%2C+R%3BStayner%2C+L&rft.aulast=Steenland&rft.aufirst=K&rft.date=1990-11-01&rft.volume=32&rft.issue=11&rft.spage=1091&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-29 N1 - Date created - 1991-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recovery of 1,3-, 2,3-dichloropropenes, 1,2-dibromo-3-chloropropane, and o-, p-dichlorobenzenes from fatty and non-fat foodstuffs by liquid extraction technique. AN - 80166711; 2256707 AB - Food samples including fatty, non-fatty, grain-based, and nongrain-based types were fortified with the following five nematocides and fumigants: 1,3-dichloropropene, 2,3-dichloropropene, 1,2-dibromo-3-chloropropane, o-dichlorobenzene, and p-dichlorobenzene. Then, depending on sample consistency and type, the samples were diluted in, or extracted with organic solvent such as isooctane. A few of the high-fat extracts were passed through Florisil to remove excess fat or endogenous interferences. Analysis of the initial or cleaned up extracts was done by gas chromatography (GC) at 90 degrees C. The dichloropropenes were determined on 20% OV-101 columns with electron-capture and Hall electroconductivity detectors. The dichlorobenzenes and 1,2-dibromo-3-chloropropane, which elute beyond 30 min on the above columns, were determined on 5%-loaded columns using the same detectors. All five analytes were recovered from these techniques. Mean analyte recovery following a direct dilution or extraction was 83%, and following the Florisil cleanup step, was 52%. In 1986, a fumigant survey of about 200 foodstuffs by using this overall technique gave no findings of the five compounds studied here. JF - Archives of environmental contamination and toxicology AU - Daft, J L AD - U.S. Department of Health and Human Services, Food and Drug Administration, Kansas City, Missouri 64106. PY - 1990 SP - 921 EP - 925 VL - 19 IS - 6 SN - 0090-4341, 0090-4341 KW - Allyl Compounds KW - 0 KW - Chlorobenzenes KW - Dietary Fats KW - Hydrocarbons, Chlorinated KW - Insecticides KW - 2-dichlorobenzene KW - 6PJ93I88XL KW - 1,2-dibromo-3-chloropropane KW - 96K0FD4803 KW - 1,3-dichloro-1-propene KW - 9H780918D0 KW - 4-dichlorobenzene KW - D149TYB5MK KW - Propane KW - T75W9911L6 KW - Index Medicus KW - Dietary Fats -- analysis KW - Propane -- analysis KW - Food Analysis KW - Propane -- analogs & derivatives KW - Food Contamination KW - Allyl Compounds -- analysis KW - Chlorobenzenes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80166711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+contamination+and+toxicology&rft.atitle=Recovery+of+1%2C3-%2C+2%2C3-dichloropropenes%2C+1%2C2-dibromo-3-chloropropane%2C+and+o-%2C+p-dichlorobenzenes+from+fatty+and+non-fat+foodstuffs+by+liquid+extraction+technique.&rft.au=Daft%2C+J+L&rft.aulast=Daft&rft.aufirst=J&rft.date=1990-11-01&rft.volume=19&rft.issue=6&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+contamination+and+toxicology&rft.issn=00904341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-24 N1 - Date created - 1991-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Physician addiction to pharmaceuticals: personal history, practice setting, access to drugs, and recovery. AN - 80094512; 2233146 AB - Specialists in the field of anesthesiology, emergency medicine, and general or family practice are at increased risk of addiction. They may manifest a pattern of habitual overwork and/or grandiosity, have unrestricted access to drugs, and initiate use through self-medication. JF - Maryland medical journal (Baltimore, Md. : 1985) AU - Wright, C AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1021 EP - 1025 VL - 39 IS - 11 SN - 0886-0572, 0886-0572 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Rehabilitation KW - Humans KW - Personality KW - Professional Practice KW - Physician Impairment KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80094512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maryland+medical+journal+%28Baltimore%2C+Md.+%3A+1985%29&rft.atitle=Physician+addiction+to+pharmaceuticals%3A+personal+history%2C+practice+setting%2C+access+to+drugs%2C+and+recovery.&rft.au=Wright%2C+C&rft.aulast=Wright&rft.aufirst=C&rft.date=1990-11-01&rft.volume=39&rft.issue=11&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Maryland+medical+journal+%28Baltimore%2C+Md.+%3A+1985%29&rft.issn=08860572&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-26 N1 - Date created - 1990-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A review of iodine toxicity reports. AN - 80093041; 2229854 AB - This article summarizes case reports, population studies, and experimental studies from the literature concerning adverse effects of exposure to iodine from the mid-1880s to 1988. Exposure to excessive iodine through foods, dietary supplements, topical medications, and/or iodinated contrast media has resulted in thyroiditis, goiter, hypothyroidism, hyperthyroidism, sensitivity reactions, or acute responses for some individuals. Reports of maternal iodine exposure during pregnancy or lactation affecting newborn or nursing infants are cited. Susceptibility to excess iodine is discussed as well as the relationship between dose and response. It is concluded that some individuals can tolerate very high levels of iodine with no apparent side effects and that iodine intakes less than or equal to 1.000 mg/day are probably safe for the majority of the population, but may cause adverse effects in some individuals. Determination of maximum tolerable levels of iodine intake will require human experimental studies at levels between 0.150 and 1.000 mg/day for normal subjects, subjects with autonomous thyroid tissue, and iodine-sensitive subjects. JF - Journal of the American Dietetic Association AU - Pennington, J A AD - Division of Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1571 EP - 1581 VL - 90 IS - 11 SN - 0002-8223, 0002-8223 KW - Iodine KW - 9679TC07X4 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Diet Surveys KW - Iodine -- administration & dosage KW - Thyroid Diseases -- epidemiology KW - Iodine -- adverse effects KW - Thyroid Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80093041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=A+review+of+iodine+toxicity+reports.&rft.au=Pennington%2C+J+A&rft.aulast=Pennington&rft.aufirst=J&rft.date=1990-11-01&rft.volume=90&rft.issue=11&rft.spage=1571&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=00028223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-13 N1 - Date created - 1990-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surveillance of occupational asthma under the SENSOR model. AN - 80073808; 2226005 JF - Chest AU - Matte, T D AU - Hoffman, R E AU - Rosenman, K D AU - Stanbury, M AD - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 173S EP - 178S VL - 98 IS - 5 Suppl SN - 0012-3692, 0012-3692 KW - Abridged Index Medicus KW - Index Medicus KW - Registries KW - Occupational Exposure KW - Humans KW - Communication KW - United States -- epidemiology KW - Asthma -- epidemiology KW - Occupational Diseases -- prevention & control KW - Asthma -- prevention & control KW - Occupational Diseases -- epidemiology KW - Models, Statistical KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80073808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Surveillance+of+occupational+asthma+under+the+SENSOR+model.&rft.au=Matte%2C+T+D%3BHoffman%2C+R+E%3BRosenman%2C+K+D%3BStanbury%2C+M&rft.aulast=Matte&rft.aufirst=T&rft.date=1990-11-01&rft.volume=98&rft.issue=5+Suppl&rft.spage=173S&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-04 N1 - Date created - 1990-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mammography in the eighties. AN - 80060275; 2217765 AB - Mammography has experienced the greatest change of any existing radiologic examination in recent years. In 1985, as a part of the Nationwide Evaluation of X-Ray Trends (NEXT) program, a national survey was conducted of a statistically selected sample (n = 232) of facilities performing mammography examinations in the United States. By 1988, the number of mammography facilities in the United States had increased to over 6,400, an increase of over 60% from the 1985 level. To assess the consequence of this expansion as well as the impact of recent technological and other significant developments on mammography, a NEXT survey of mammography facilities was repeated in 1988 (n = 226). Screen-film mammography accounted for 83% of the facilities surveyed in 1988, and dedicated equipment dominated screen-film systems (99%). There was a 26% increase in the overall mean phantom image score, over 45% increase in the use of grids, and 10% increase in mean glandular dose for systems using grids. JF - Radiology AU - Conway, B J AU - McCrohan, J L AU - Rueter, F G AU - Suleiman, O H AD - Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20857. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 335 EP - 339 VL - 177 IS - 2 SN - 0033-8419, 0033-8419 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Radiation Dosage KW - Xeromammography -- trends KW - Mammography -- trends KW - X-Ray Intensifying Screens KW - Ambulatory Care Facilities -- supply & distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80060275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Mammography+in+the+eighties.&rft.au=Conway%2C+B+J%3BMcCrohan%2C+J+L%3BRueter%2C+F+G%3BSuleiman%2C+O+H&rft.aulast=Conway&rft.aufirst=B&rft.date=1990-11-01&rft.volume=177&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Average radiation exposure values for three diagnostic radiographic examinations. AN - 80058694; 2217766 AB - National surveys of more than 600 facilities that performed chest, lumbosacral spine, and abdominal examinations were conducted as a part of the Nationwide Evaluation of X-Ray Trends program. Radiation exposures were measured with use of a set of standard phantoms developed by the Center for Devices and Radiological Health of the Food and Drug Administration, U.S. Public Health Service. X-ray equipment parameters, film processing data, and data regarding techniques used were collected. There were no differences in overall posteroanterior chest exposures between hospitals and private practices. Seventy-six percent of hospitals used grids, compared with 33% of private practices. In general, hospitals favored a high tube voltage technique, and private facilities favored a low tube voltage technique. Forty-one percent of private practices and 17% of hospitals underprocessed their film. Underprocessing in hospitals increased from 17% in 1984 to 33% in 1987. Average exposure values for these examinations may be useful as guidelines in meeting some of the new requirements of the Joint Commission on Accreditation of Healthcare Organizations. JF - Radiology AU - Rueter, F G AU - Conway, B J AU - McCrohan, J L AU - Suleiman, O H AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 341 EP - 345 VL - 177 IS - 2 SN - 0033-8419, 0033-8419 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Radiology Department, Hospital KW - Humans KW - Health Facilities, Proprietary KW - Lumbar Vertebrae -- diagnostic imaging KW - Sacrum -- diagnostic imaging KW - Radiography, Abdominal KW - Sweden KW - Radiography, Thoracic KW - Radiation Dosage KW - Environmental Exposure KW - Radiography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80058694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Average+radiation+exposure+values+for+three+diagnostic+radiographic+examinations.&rft.au=Rueter%2C+F+G%3BConway%2C+B+J%3BMcCrohan%2C+J+L%3BSuleiman%2C+O+H&rft.aulast=Rueter&rft.aufirst=F&rft.date=1990-11-01&rft.volume=177&rft.issue=2&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk-based oversight of experiments in the environment. AN - 80107837; 2237398 JF - Science (New York, N.Y.) AU - Miller, H I AU - Burris, R H AU - Vidaver, A K AU - Wivel, N A AD - Office of Biotechnology, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/10/26/ PY - 1990 DA - 1990 Oct 26 SP - 490 EP - 491 VL - 250 IS - 4980 SN - 0036-8075, 0036-8075 KW - DNA, Recombinant KW - 0 KW - Index Medicus KW - United States KW - Risk KW - National Institutes of Health (U.S.) KW - Environmental Pollution -- prevention & control KW - Biotechnology -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80107837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Risk-based+oversight+of+experiments+in+the+environment.&rft.au=Miller%2C+H+I%3BBurris%2C+R+H%3BVidaver%2C+A+K%3BWivel%2C+N+A&rft.aulast=Miller&rft.aufirst=H&rft.date=1990-10-26&rft.volume=250&rft.issue=4980&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-06 N1 - Date created - 1990-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of leucovorin on idoxuridine cytotoxicity and DNA incorporation. AN - 80013559; 2208128 AB - Leucovorin (LV) increased the growth inhibition produced by iododeoxyuridine (IdUrd), a halogenated analogue of thymidine, in a murine tumor cell line (L1210) and three human tumor cell lines (HL-60, HT-29, and MCF-7). This increased growth inhibition was associated with increased incorporation of IdUrd into DNA. Consistent with previous reports, IdUrd (as iododeoxyuridine monophosphate) inhibited thymidylate synthase (TS) and was dehalogenated intracellularly by TS to generate thymidine nucleotides. In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd. In intact L1210 cells, apparent TS activity was inhibited 50% by 3 microM IdUrd alone and 75% by the combination of 3 microM IdUrd and 20 microM LV. Apparent TS activity was unchanged with 20 microM LV alone. In all cell lines except HL-60, the ratios of labeled iododeoxyuridine triphosphate/dTTP derived from tritiated IdUrd were 3-fold lower than the labeled IdUrd/thymidine ratios in DNA. This observation suggests that replicative DNA polymerases preferentially incorporate iododeoxyuridine triphosphate into DNA compared to the endogenous substrate dTTP. This preferential incorporation was independent of the effect of LV. These novel findings suggested that a potential mechanism for the effects of LV on IdUrd was increased inhibition of TS analogous to the interaction between fluoropyrimidines and LV. Enzyme inhibition studies using L1210 cell extracts showed that iododeoxyuridine monophosphate was a weak inhibitor of TS (Ki greater than 10 microM) when compared to 5-fluorodeoxyuridine monophosphate (Ki less than 10 nM). Despite the major differences in potency of these two halogenated pyrimidines, LV appears to modulate the activity of IdUrd as well as 5-fluorodeoxyuridine. LV may provide a clinically useful approach to improve the radiosensitizing and/or cytotoxic properties of IdUrd. JF - Cancer research AU - Greene, R F AU - Collins, J M AD - Office of Research Resources, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1990/10/15/ PY - 1990 DA - 1990 Oct 15 SP - 6652 EP - 6656 VL - 50 IS - 20 SN - 0008-5472, 0008-5472 KW - Thymine Nucleotides KW - 0 KW - DNA KW - 9007-49-2 KW - Thymidylate Synthase KW - EC 2.1.1.45 KW - Idoxuridine KW - LGP81V5245 KW - Leucovorin KW - Q573I9DVLP KW - thymidine 5'-triphosphate KW - QOP4K539MU KW - Index Medicus KW - Thymidylate Synthase -- analysis KW - Thymidylate Synthase -- antagonists & inhibitors KW - Thymine Nucleotides -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Drug Synergism KW - Idoxuridine -- pharmacology KW - Idoxuridine -- metabolism KW - DNA -- metabolism KW - Leucovorin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80013559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Effects+of+leucovorin+on+idoxuridine+cytotoxicity+and+DNA+incorporation.&rft.au=Greene%2C+R+F%3BCollins%2C+J+M&rft.aulast=Greene&rft.aufirst=R&rft.date=1990-10-15&rft.volume=50&rft.issue=20&rft.spage=6652&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extrapolation of animal toxicity to humans: interspecies comparisons in drug development. AN - 80172601; 2259752 AB - Different methods for converting the dose-related toxicity of drugs from animals to humans are reviewed. Each method is analyzed with respect to its utility and limitations. Linear extrapolations from animals to humans based on body weight equivalence are shown to be inaccurate unless species-specific conversion factors are used. Extrapolations based on surface area equivalence are more accurate, do not require conversion factors, and may be used when pharmacokinetic data are not available. Ultimately, interspecies conversions are most reliable when pharmacokinetic data are available, assuming that toxic responses are comparable among species for similar blood levels. Two pharmacokinetic-based approaches may be used: direct use of plasma concentration or area under the concentration-time curve (AUC) and physiologically based pharmacokinetic (PBPK) models. JF - Regulatory toxicology and pharmacology : RTP AU - Voisin, E M AU - Ruthsatz, M AU - Collins, J M AU - Hoyle, P C AD - U.S. Food and Drug Administration, Division of Antiviral Drug Products, Rockville, MD 20857. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 107 EP - 116 VL - 12 IS - 2 SN - 0273-2300, 0273-2300 KW - Index Medicus KW - Animals KW - Humans KW - Models, Biological KW - Drug Design KW - Drug-Related Side Effects and Adverse Reactions KW - Species Specificity KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80172601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Extrapolation+of+animal+toxicity+to+humans%3A+interspecies+comparisons+in+drug+development.&rft.au=Voisin%2C+E+M%3BRuthsatz%2C+M%3BCollins%2C+J+M%3BHoyle%2C+P+C&rft.aulast=Voisin&rft.aufirst=E&rft.date=1990-10-01&rft.volume=12&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-31 N1 - Date created - 1991-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mental health and the workplace. An interchangeable partnership. AN - 80158989; 2252236 AB - Mental health is an important component of occupational health. The National Institute for Occupational Safety and Health (NIOSH) recognizes psychological disorders as one of the 10 leading work-related diseases and injuries (Millar, 1984). Job-related stress is receiving an increasing amount of public attention, and several studies indicate that stress-related conditions are among the most important health problems of the 1990s for people at work and outside of work. JF - The American psychologist AU - Millar, J D AD - NIOSH Centers for Disease Control, Atlanta, GA. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 1165 EP - 1166 VL - 45 IS - 10 SN - 0003-066X, 0003-066X KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Health KW - Occupational Diseases -- psychology KW - Accidents, Occupational -- psychology KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80158989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+psychologist&rft.atitle=Mental+health+and+the+workplace.+An+interchangeable+partnership.&rft.au=Millar%2C+J+D&rft.aulast=Millar&rft.aufirst=J&rft.date=1990-10-01&rft.volume=45&rft.issue=10&rft.spage=1165&rft.isbn=&rft.btitle=&rft.title=The+American+psychologist&rft.issn=0003066X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-15 N1 - Date created - 1991-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevention of work-related psychological disorders. A national strategy proposed by the National Institute for Occupational Safety and Health (NIOSH). AN - 80157812; 2252233 AB - The National Institute for Occupational Safety and Health (NIOSH) recognizes psychological disorders as a leading occupational health problem. This document, developed by a NIOSH working group led by the present authors, represents a first attempt to fashion a comprehensive national strategy to protect and promote the psychological health of workers. Roles are identified for industry, labor, government, and academia. Key initiatives include (a) steps to improve working conditions and employee mental health services and (b) increased research and surveillance to advance understanding of the problem. Because work-related psychological disorders appear to be a rapidly developing problem lacking complete definition in terms of scope and etiology, this strategy is not to be considered a final statement of NIOSH policy. JF - The American psychologist AU - Sauter, S L AU - Murphy, L R AU - Hurrell, J J AD - National Institute for Occupational Safety and Health, Cincinnati, OH. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 1146 EP - 1158 VL - 45 IS - 10 SN - 0003-066X, 0003-066X KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Mental Disorders -- prevention & control KW - Occupational Diseases -- prevention & control KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80157812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+psychologist&rft.atitle=Prevention+of+work-related+psychological+disorders.+A+national+strategy+proposed+by+the+National+Institute+for+Occupational+Safety+and+Health+%28NIOSH%29.&rft.au=Sauter%2C+S+L%3BMurphy%2C+L+R%3BHurrell%2C+J+J&rft.aulast=Sauter&rft.aufirst=S&rft.date=1990-10-01&rft.volume=45&rft.issue=10&rft.spage=1146&rft.isbn=&rft.btitle=&rft.title=The+American+psychologist&rft.issn=0003066X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-15 N1 - Date created - 1991-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational hazards to health care workers: diverse, ill-defined, and not fully appreciated. AN - 80157342; 2174654 AB - Health care workers are challenged by an imposing group of occupational hazards. These hazards include exposure to ionizing radiation, stress, injury, infectious agents, and chemicals. The magnitude and diversity of these hazards are not fully appreciated. The acquired immunodeficiency syndrome epidemic has created additional occupational hazards and has focused attention on the problem of occupational hazards to health care workers. Concern over the nosocomial transmission of the human immunodeficiency virus has contributed to efforts to implement universal infection control precautions and to decrease needlestick injuries. Health care organizations and providers, who have prompted health and safety campaigns for the general public, should not overlook the dangers associated with the health care setting. JF - American journal of infection control AU - Moore, R M AU - Kaczmarek, R G AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 316 EP - 327 VL - 18 IS - 5 SN - 0196-6553, 0196-6553 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Hazardous Substances -- adverse effects KW - HIV Infections -- transmission KW - Cross Infection -- transmission KW - Centers for Disease Control and Prevention (U.S.) KW - Risk Factors KW - Radiation Injuries -- prevention & control KW - Humans KW - Wounds and Injuries KW - Violence KW - Stress, Physiological KW - Radiation, Ionizing KW - Occupational Diseases -- etiology KW - Health Manpower UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80157342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=Occupational+hazards+to+health+care+workers%3A+diverse%2C+ill-defined%2C+and+not+fully+appreciated.&rft.au=Moore%2C+R+M%3BKaczmarek%2C+R+G&rft.aulast=Moore&rft.aufirst=R&rft.date=1990-10-01&rft.volume=18&rft.issue=5&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=01966553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-17 N1 - Date created - 1991-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Age-related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL-associated serine esterase genes and the perforin gene in mice. AN - 80124648; 2242759 AB - The age-related decline in cytotoxic T lymphocyte (CTL) activity has been recognized for many years. Age-related alterations in several immunologic events have been suggested to be partly or completely responsible for this decline. We had previously demonstrated (Bloom et al., Cell. Immunol. 1988. 144: 440) in mice that a deterioration in the lytic mechanism may be at least in part responsible for the decline in CTL activity. We now report that this decline correlates with an age-related decrease in serine esterase activity released into the supernatant medium in the process of generating CTL. Northern analyses were then used to examine the effect of age on expression of genes encoding for perforin and two CTL-associated serine esterases. The products of all three of these genes have all been postulated to play roles in CTL-mediated lysis. We show that the expression of all three of these genes appears to decline with age in the process of generating allogeneic CTL. These alterations in gene expression correlated both with diminished cytolytic and released esterase activities generated by mixed leukocyte culture in spleen cells of old mice compared to young. The age-related decline in gene expression could not be attributed to shifts in T cell subsets, but CD8+ cells generated by allogeneic stimulation of nylon wool-passed spleen cells from old mice expressed significantly less cytolytic activity than those from young. This report is the first demonstration of an age-related decrease in expression of a functionally related group of genes. In addition, these findings are compatible with the suggested roles for perforin and serine esterase release in CTL-mediated target cell lysis. JF - European journal of immunology AU - Bloom, E T AU - Umehara, H AU - Bleackley, R C AU - Okumura, K AU - Mostowski, H AU - Babbitt, J T AD - Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 2309 EP - 2316 VL - 20 IS - 10 SN - 0014-2980, 0014-2980 KW - Membrane Glycoproteins KW - 0 KW - Membrane Proteins KW - Pore Forming Cytotoxic Proteins KW - RNA, Messenger KW - Perforin KW - 126465-35-8 KW - Esterases KW - EC 3.1.- KW - serine esterase KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Gene Expression KW - Transcription, Genetic KW - Mice KW - Mice, Inbred BALB C KW - Cells, Cultured KW - Lymphocyte Activation -- immunology KW - T-Lymphocyte Subsets -- immunology KW - Mice, Inbred C57BL KW - Cytotoxicity Tests, Immunologic KW - Female KW - Esterases -- genetics KW - T-Lymphocytes, Cytotoxic -- immunology KW - Membrane Proteins -- genetics KW - RNA, Messenger -- genetics KW - Aging -- immunology KW - T-Lymphocytes, Cytotoxic -- enzymology KW - RNA, Messenger -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80124648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=Age-related+decrement+in+cytotoxic+T+lymphocyte+%28CTL%29+activity+is+associated+with+decreased+levels+of+mRNA+encoded+by+two+CTL-associated+serine+esterase+genes+and+the+perforin+gene+in+mice.&rft.au=Bloom%2C+E+T%3BUmehara%2C+H%3BBleackley%2C+R+C%3BOkumura%2C+K%3BMostowski%2C+H%3BBabbitt%2C+J+T&rft.aulast=Bloom&rft.aufirst=E&rft.date=1990-10-01&rft.volume=20&rft.issue=10&rft.spage=2309&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-28 N1 - Date created - 1990-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene. AN - 80019451; 2208586 AB - Recent reports have indicated that 1-nitropyrene is tumorigenic in laboratory animals. Since it is generally accepted that the covalent binding of carcinogens to DNA is causally related to tumorigenesis, we used 32P-postlabeling to examine the DNA adducts present in target tissues. 1-Nitropyrene (99.85-99.98% 1-nitropyrene, 0.15-0.02% 1,3-, 1,6- and 1,8-dinitropyrene by mass spectral analyses) was administered to Sprague-Dawley rats, CD-1 mice and A/J mice according to three tumorigenesis protocols. In DNA obtained from the injection site of Sprague-Dawley rats, two major adducts were observed. Based upon their chromatographic behavior and sensitivities to treatment with nuclease P1 and hydrazine, these adducts were identified as N-(deoxyguanosin-8-yl)-1-aminopyrene (dG-C8-AP) and N-(deoxyguanosin-8-yl)-1-amino-3-, 6- and/or 8-nitropyrene (dG-C8-ANP), which are adducts derived from the nitroreduction of 1-nitropyrene and dinitropyrenes respectively. In mammary gland DNA from Sprague-Dawley rats, two adducts were found. One of these had chromatographic characteristics and hydrazine and nuclease P1 sensitivities similar to dG-C8-AP, while the identity of the other adduct is presently unknown. The only DNA adduct detected in the livers of newborn CD-1 mice and the lungs of A/J mice was dG-C8-ANP. The presence of dG-C8-AP in the injection site and mammary gland of the Sprague-Dawley rats indicates that nitroreduction is involved in the metabolic activation of 1-nitropyrene in these tissues. Since an unidentified adduct was also found in the mammary gland, other pathways are important in this tissue. The presence of only dinitropyrene DNA adducts in the livers of CD-1 mice and lungs of A/J mice indicates that dinitropyrenes are activated very efficiently to electrophilic metabolites, to an extent far better than 1-nitropyrene. JF - Carcinogenesis AU - Smith, B A AU - Korfmacher, W A AU - Beland, F A AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 1705 EP - 1710 VL - 11 IS - 10 SN - 0143-3334, 0143-3334 KW - Phosphorus Radioisotopes KW - 0 KW - Pyrenes KW - Tritium KW - 10028-17-8 KW - DNA KW - 9007-49-2 KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Animals KW - Mass Spectrometry KW - Mice KW - Autoradiography KW - Rats KW - Rats, Inbred Strains KW - Mice, Inbred A KW - Mice, Inbred Strains KW - Biotransformation KW - Female KW - Male KW - DNA -- metabolism KW - Pyrenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80019451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=DNA+adduct+formation+in+target+tissues+of+Sprague-Dawley+rats%2C+CD-1+mice+and+A%2FJ+mice+following+tumorigenic+doses+of+1-nitropyrene.&rft.au=Smith%2C+B+A%3BKorfmacher%2C+W+A%3BBeland%2C+F+A&rft.aulast=Smith&rft.aufirst=B&rft.date=1990-10-01&rft.volume=11&rft.issue=10&rft.spage=1705&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-14 N1 - Date created - 1990-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Child Health USA '90. AN - 62995686; ED331242 AB - The report summarizes the health status and service needs of children in the United States. The first of the report's three sections describes the general population to provide a context for health measures. In the second section selected health status measures are presented graphically with accompanying text organized according to three age groups--infants, children, and adolescents. In the third section, measures of health services utilization are presented. Topics addressed include: poverty; family structure; child care; school dropouts; infant mortality; neonatal and post-neonatal mortality; low birth weight; infant feeding; congenital anomalies; child mortality; child hospitalization; limitation of activity due to chronic diseases; oral health; injuries; child abuse and neglect; childhood obesity; causes of death among 10-19 year olds; teenage sexuality; child, adolescent, and young adult AIDS (Acquired Immune Deficiency Syndrome); substance abuse; childhood immunization; prenatal care; physician visits; physician/hospital utilization by income status; health care financing; Medicaid coverage; use of physician services by perceived health status; and physician/hospital utilization in children with chronic conditions. (DB) Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 52 VL - HRS-M-CH-90-1 KW - ERIC, Resources in Education (RIE) KW - Death KW - Child Health KW - Needs Assessment KW - Children KW - Sexuality KW - Health Services KW - Poverty KW - Disabilities KW - Child Neglect KW - Statistical Data KW - Incidence KW - Special Health Problems KW - Diseases KW - Child Abuse KW - Physical Health KW - Adolescents KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62995686?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Photographs will not reproduce. N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Ojibway Adolescent Time Spent with Parents/Elders as Related to Delinquency and Court Adjudication Experiences AN - 61214181; 91X5648 AB - Interview data collected from 94 Ojibway Indian adolescents living on a rural Indian reservation are used to explore the relationship between time spent with their families & deliquency behaviors & court adjudication. Results indicate that adolescents living with a natural parent & experiencing more family contact committed fewer deliquent acts & were less involved with court adjudication. Increased frequency of family dysfunctional factors served as a predictor of delinquency. Overall, the results mirror the adolescent dilemma found in US families in general. Recommendations are presented for helping professionals working in reservation communities & reservation leaders. 3 Tables, 1 Figure, 9 References. Adapted from the source document. JF - American Indian and Alaska Native Mental Health Research AU - Zitzow, Darryl AD - PHS Indian Health Service White Earth Clinic, MN 56591 Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 53 EP - 63 VL - 4 IS - 1 SN - 0893-5394, 0893-5394 KW - delinquency/court adjudication, Ojibway Indian adolescents KW - family time/parental attention KW - interviews KW - American Indian Reservations KW - Juvenile Delinquency KW - Traditional Societies KW - Parent Child Relations KW - Adolescents KW - American Indians KW - article KW - 2151: social problems and social welfare; juvenile delinquency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61214181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Indian+and+Alaska+Native+Mental+Health+Research&rft.atitle=Ojibway+Adolescent+Time+Spent+with+Parents%2FElders+as+Related+to+Delinquency+and+Court+Adjudication+Experiences&rft.au=Zitzow%2C+Darryl&rft.aulast=Zitzow&rft.aufirst=Darryl&rft.date=1990-10-01&rft.volume=4&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=American+Indian+and+Alaska+Native+Mental+Health+Research&rft.issn=08935394&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AIAREB N1 - SubjectsTermNotLitGenreText - Traditional Societies; American Indians; Adolescents; American Indian Reservations; Juvenile Delinquency; Parent Child Relations ER - TY - BOOK T1 - States' assessment of health personnel shortages: issues and concerns T2 - Dept. of Health and Human Services. DHHS pubn. no. HRS-P-OD 90-6 AN - 59571574; 1991-0713076 AB - Health manpower shortages as reported by 56 US jurisdictions to a congressional inquiry begun in Sept. 1989. Shortages of registered nurses, primary care practitioners, and rural health care personnel. JF - Washington, DC 20447, October 1990. 54+39 pp. Y1 - 1990/10// PY - 1990 DA - October 1990 EP - 54+39 PB - Washington, DC 20447 KW - United States -- Medical sector KW - Medical service, Rural -- United States KW - Medical profession -- Supply and demand KW - Medical workers -- Supply and demand KW - Nursing -- Supply and demand KW - Medical workers -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59571574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-10-01&rft.volume=&rft.issue=&rft.spage=54%2B39&rft.isbn=&rft.btitle=States%27+assessment+of+health+personnel+shortages%3A+issues+and+concerns&rft.title=States%27+assessment+of+health+personnel+shortages%3A+issues+and+concerns&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20447 pa N1 - Document feature - map(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Propanil-induced methemoglobinemia and hemoglobin binding in the rat. AN - 80112057; 2237922 AB - Administration of [ring-U-14C]propanil (3,4-dichloropropionanilide) to male Sprague-Dawley rats (30, 100, and 300 mg/kg, ip) increased the formation of methemoglobin at the two highest doses. Following a propanil dose of 100 mg/kg, methemoglobin formation attained a maximum level of 5% by 1.5 hr and declined to normal levels (approximately 2.5%) by 12 hr. Hemoglobin binding attained a maximum level of 50 pmol/mg protein by 12 hr, and remained constant for 24 hr. Following a propanil dose of 300 mg/kg, methemoglobin formation attained a maximum level of 24% by 4.5 hr, and declined to a level of 5% by 24 hr. Hemoglobin binding attained a maximum level of 425 pmol/mg protein by 12 hr, and remained constant for 24 hr. Hemoglobin binding was also detected at the lowest propanil dose (10 pmol/mg protein) even though methemoglobin formation was not observed. HPLC analysis of alkaline-treated hemoglobin from propanil-treated rats indicated the presence of one radiolabeled compound with the same HPLC retention time as 3,4-dichloraniline. These data are consistent with the concept that propanil is converted to N-hydroxy-3,4-dichloroaniline in the liver. Subsequently, this metabolite enters the erythrocyte and is oxidized by hemoglobin to 3,4-dichloronitrosobenzene with concomitant conversion of oxyhemoglobin to methemoglobin. The 3,4-dichloronitrosobenzene binds to cysteine residues on hemoglobin as the corresponding sulfinic acid amide adduct. These data suggest that human exposure to propanil may be monitored in the absence of observable toxicity by the analysis of propanil metabolites bound to hemoglobin. JF - Toxicology and applied pharmacology AU - McMillan, D C AU - McRae, T A AU - Hinson, J A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990/09/15/ PY - 1990 DA - 1990 Sep 15 SP - 503 EP - 507 VL - 105 IS - 3 SN - 0041-008X, 0041-008X KW - Carbon Radioisotopes KW - 0 KW - Hemoglobins KW - Propanil KW - 709-98-8 KW - Methemoglobin KW - 9008-37-1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Methemoglobin -- biosynthesis KW - Time Factors KW - Protein Binding KW - Male KW - Hemoglobins -- metabolism KW - Propanil -- metabolism KW - Methemoglobinemia -- chemically induced KW - Methemoglobinemia -- metabolism KW - Propanil -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80112057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Propanil-induced+methemoglobinemia+and+hemoglobin+binding+in+the+rat.&rft.au=McMillan%2C+D+C%3BMcRae%2C+T+A%3BHinson%2C+J+A&rft.aulast=McMillan&rft.aufirst=D&rft.date=1990-09-15&rft.volume=105&rft.issue=3&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-12 N1 - Date created - 1990-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Automated surface area measurement of cultured cardiac myocytes. AN - 80338413; 1370025 AB - An automated method for rapidly measuring surface area of individual cardiac myocytes was used as an index of myocyte growth. Hearts from 2- to 4-day-old rats were digested by overnight incubation in cold trypsin solution. Enriched suspensions of myocytes were plated at 2 x 10(5) cells/well in 12-well-culture plates. Cells were grown in M199 supplemented with 1%, 10% serum or 10% serum plus 10(-7) M norepinephrine. On days 1-4 after plating, cells were fixed in Bouin's Solution and stained with Weigert's Iron Hematoxylin and Biebrich Scarlet-Acid Fuchsin. An inverted microscope, video camera and monitor were coupled to a video image processor (Image Technology Corp.). The enhanced image of stained heart cells was digitized, and perimeter, length, width and area of each selected cell were calculated. One hundred randomly selected cells were measured in each of eight wells from each treatment-day group. Areas of individual myocytes varied widely in culture dishes and the distribution was skewed toward larger cells. The standard deviation increased in proportion to an increase in mean cell area. A logarithmic transformation of the data normalized the data and yielded a more homogeneous variance. The geometric mean area of heart cells supplemented with 1% serum increased only slightly, but significantly, during four days in culture. Geometric mean area of cells supplemented with 10% serum increased nearly four-fold. Supplementing cells with norepinephrine (10(-7) M) in addition to 10% serum did not induce a further increase in cell size. This technique has the potential to rapidly and objectively monitor heart cell growth following pharmacological or toxicological treatments. JF - Cytotechnology AU - Toraason, M AU - Krueger, J A AU - Busch, K A AU - Shaw, P B AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 155 EP - 161 VL - 4 IS - 2 SN - 0920-9069, 0920-9069 KW - Biotechnology KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Analysis of Variance KW - Cells, Cultured KW - Staining and Labeling -- methods KW - Cell Division -- physiology KW - Surface Properties KW - Myocardium -- cytology KW - Image Processing, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80338413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytotechnology&rft.atitle=Automated+surface+area+measurement+of+cultured+cardiac+myocytes.&rft.au=Toraason%2C+M%3BKrueger%2C+J+A%3BBusch%2C+K+A%3BShaw%2C+P+B&rft.aulast=Toraason&rft.aufirst=M&rft.date=1990-09-01&rft.volume=4&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Cytotechnology&rft.issn=09209069&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-03 N1 - Date created - 1991-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Screening for bladder cancer in high-risk groups: delineation of the problem. AN - 80281116; 2074499 AB - Since 1895, various exogenous chemicals and occupations have been identified as risk factors for bladder cancer. The aromatic amines are among the most notable chemicals. To date, numerous groups of workers and, in some cases, community residents, who are at increased risk of bladder cancer have come to the attention of health officials and have sought guidance concerning screening for bladder cancer. Most of these persons are asymptomatic, but they may not have attained the average length of preclinical latency for aromatic amine-induced cancer. Although the principal public health strategy for combatting occupational exposure to carcinogens is primary prevention, screening is another strategy that can be used for those already exposed to known or suspected carcinogens. Screening also can be used to assess whether or not environmental controls are needed or need to be improved. For more than a decade the question of screening has been problematic with regard to occupational groups where known exposures have been documented. The question facing government, labor, industry, and academia is what to recommend with regard to screening high-risk groups. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Schulte, P A AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 789 EP - 792 VL - 32 IS - 9 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - Risk Factors KW - Humans KW - Mass Screening KW - Urinary Bladder Neoplasms -- prevention & control KW - Occupational Diseases -- prevention & control KW - Urinary Bladder Neoplasms -- mortality KW - Occupational Diseases -- chemically induced KW - Urinary Bladder Neoplasms -- chemically induced KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80281116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Screening+for+bladder+cancer+in+high-risk+groups%3A+delineation+of+the+problem.&rft.au=Schulte%2C+P+A&rft.aulast=Schulte&rft.aufirst=P&rft.date=1990-09-01&rft.volume=32&rft.issue=9&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-15 N1 - Date created - 1991-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Screening workers exposed to 4,4'-methylenebis(2-chloroaniline) for bladder cancer by cystoscopy. AN - 80280417; 2074509 AB - A bladder cancer incidence study was conducted among 540 workers exposed to the potential bladder carcinogen 4,4'-methylenebis(2-chloroaniline) from 1969 to 1979. Among the 385 workers who participated in a urine screening examination, none had suspicious or positive cytology. Twenty-one workers had at least one reading of atypia and 60 had either a positive dipstick for heme or greater than five red blood cells per low power field. The study protocol initially involved referral to private physicians for follow-up of any suspicious laboratory results. However, the diagnosis by cystoscopy of a bladder tumor in a nonsmoking man less than 30 years old with low-level hematuria prompted us to offer cystoscopy to all members of the cohort. A total of three tumors were identified in 200 persons who received cystoscopy. All were low-grade, papillary tumors and two occurred in men with completely normal urine screening results. These findings suggest that cystoscopy of asymptomatic persons should be considered in designing bladder cancer screening programs in high-risk cohorts. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Ward, E AU - Halperin, W AU - Thun, M AU - Grossman, H B AU - Fink, B AU - Koss, L AU - Osorio, A M AU - Schulte, P AD - Division of Hazard Evaluations, National Institute for Occupational Safety and Health, Cincinnati 45226. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 865 EP - 868 VL - 32 IS - 9 SN - 0096-1736, 0096-1736 KW - Methylenebis(chloroaniline) KW - 3L2W5VTT2A KW - Index Medicus KW - Occupational Exposure KW - Risk Factors KW - Humans KW - Adult KW - Incidence KW - Cystoscopy KW - Male KW - Hematuria -- etiology KW - Urinary Bladder Neoplasms -- epidemiology KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- chemically induced KW - Mass Screening -- methods KW - Urinary Bladder Neoplasms -- chemically induced KW - Methylenebis(chloroaniline) -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80280417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Screening+workers+exposed+to+4%2C4%27-methylenebis%282-chloroaniline%29+for+bladder+cancer+by+cystoscopy.&rft.au=Ward%2C+E%3BHalperin%2C+W%3BThun%2C+M%3BGrossman%2C+H+B%3BFink%2C+B%3BKoss%2C+L%3BOsorio%2C+A+M%3BSchulte%2C+P&rft.aulast=Ward&rft.aufirst=E&rft.date=1990-09-01&rft.volume=32&rft.issue=9&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-15 N1 - Date created - 1991-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - National estimates of occupational exposure to animal bladder tumorigens. AN - 80272998; 2074501 AB - A prevention program for occupational bladder cancer should be based on an estimate of the number of workers previously and currently exposed to bladder carcinogens. The National Occupational Exposure Survey (NOES), which identified potential occupational exposures in approximately 5000 private sector firms in 1981 to 1983, is the best available source for recent hazard estimates; the National Occupational Hazard Survey (NOHS), conducted in 1972 and 1974, for past exposure estimates. The National Institute for Occupational Safety and Health Registry of Toxic Effects of Chemical Substances (RTECS) identified nearly 200 substances associated with animal bladder tumors. From NOES and NOHS, the numbers of workers with full time (greater than or equal to 4 hours/day) or any potential occupational exposure were estimated for the United States. About 60,000 workers were potentially exposed in the early 1970s and about 700,000 in the early 1980s on a full-time basis to the compounds on the RTECS list also appearing in NOES, and about 1.8 million workers in the 1970s and almost 3.5 million in the 1980s had some occupational exposure. Because matches were not found for many compounds and because NOES covers only part of the US work force, these are probably underestimates. The estimates for the number of exposed workers do not imply that these workers all have increased risk of developing bladder cancer, because some animal tumorigens may not be human carcinogens and our estimates are based on potential rather than measured exposures. The risk would depend on the potency, duration, and intensity of the actual exposures. Nevertheless these estimates are useful in estimating the approximate magnitude of the potential occupational exposure to animal bladder tumorigens. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Ruder, A M AU - Fine, L J AU - Sundin, D S AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 797 EP - 805 VL - 32 IS - 9 SN - 0096-1736, 0096-1736 KW - Carcinogens KW - 0 KW - Index Medicus KW - United States KW - Registries KW - Animals KW - Urinary Bladder Neoplasms -- prevention & control KW - Risk Factors KW - Humans KW - European Continental Ancestry Group KW - Databases, Factual KW - Male KW - Urinary Bladder Neoplasms -- chemically induced KW - Occupational Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80272998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=National+estimates+of+occupational+exposure+to+animal+bladder+tumorigens.&rft.au=Ruder%2C+A+M%3BFine%2C+L+J%3BSundin%2C+D+S&rft.aulast=Ruder&rft.aufirst=A&rft.date=1990-09-01&rft.volume=32&rft.issue=9&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-15 N1 - Date created - 1991-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ion-pairing liquid chromatographic determination of benzimidazole fungicides in foods. AN - 80212839; 2273000 AB - A method is described for determining residues in foods of thiabendazole, thiophanate methyl, the di-oxygen analogue metabolite [dimethyl 4,4'-O-phenylene bis (allophanate)] that is the metabolite name of the latter, and methyl-2-benzimidazole carbamate, which is the major metabolite and fungitoxic principle common to both thiophanate methyl and benomyl. The residues are extracted from the product using methanol and are partitioned into dichloromethane after initial acidification and again after subsequent alkalinization of the extract. Residues are separated and quantified by reverse-phase liquid chromatography using an ion-pairing mobile phase with UV and fluorescence detectors in tandem. Recoveries from 7 different food crops fortified at 0.2-35 ppm levels ranged from 64 to 105%. JF - Journal - Association of Official Analytical Chemists AU - Gilvydis, D M AU - Walters, S M AD - Food and Drug Administration, Pesticides and Industrial Chemicals Research Center, Detroit, MI 48207. PY - 1990 SP - 753 EP - 761 VL - 73 IS - 5 SN - 0004-5756, 0004-5756 KW - Benzimidazoles KW - 0 KW - Carbamates KW - Fungicides, Industrial KW - Indicators and Reagents KW - Thiophanate KW - 5Q0Y96D5I8 KW - carbendazim KW - H75J14AA89 KW - Thiabendazole KW - N1Q45E87DT KW - Benomyl KW - TLW21058F5 KW - Index Medicus KW - Spectrometry, Fluorescence KW - Hydrogen-Ion Concentration KW - Temperature KW - Spectrophotometry, Ultraviolet KW - Chromatography, Liquid KW - Benomyl -- analysis KW - Thiophanate -- analysis KW - Thiabendazole -- analysis KW - Food Analysis -- instrumentation KW - Fungicides, Industrial -- analysis KW - Benzimidazoles -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80212839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Ion-pairing+liquid+chromatographic+determination+of+benzimidazole+fungicides+in+foods.&rft.au=Gilvydis%2C+D+M%3BWalters%2C+S+M&rft.aulast=Gilvydis&rft.aufirst=D&rft.date=1990-09-01&rft.volume=73&rft.issue=5&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-28 N1 - Date created - 1991-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Examination of the potential long-lasting protective effect of ICRF-187 against anthracycline-induced chronic cardiomyopathy. AN - 80212604; 2125530 JF - Cancer treatment reviews AU - Herman, E H AU - Ferrans, V J AD - Division of Drug Research and Testing, Food and Drug, Administration, Washington, D.C. 20204. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 155 EP - 160 VL - 17 IS - 2-3 SN - 0305-7372, 0305-7372 KW - Razoxane KW - 5AR83PR647 KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Myofibrils -- pathology KW - Myofibrils -- drug effects KW - Animals KW - Vacuoles -- drug effects KW - Vacuoles -- pathology KW - Myocardium -- pathology KW - Rabbits KW - Chronic Disease KW - Time Factors KW - Male KW - Razoxane -- therapeutic use KW - Cardiomyopathies -- pathology KW - Daunorubicin -- adverse effects KW - Cardiomyopathies -- prevention & control KW - Cardiomyopathies -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80212604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+treatment+reviews&rft.atitle=Examination+of+the+potential+long-lasting+protective+effect+of+ICRF-187+against+anthracycline-induced+chronic+cardiomyopathy.&rft.au=Herman%2C+E+H%3BFerrans%2C+V+J&rft.aulast=Herman&rft.aufirst=E&rft.date=1990-09-01&rft.volume=17&rft.issue=2-3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Cancer+treatment+reviews&rft.issn=03057372&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-27 N1 - Date created - 1991-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gas chromatographic determination of incurred dimetridazole residues in swine tissues. AN - 80211594; 2272993 AB - A gas chromatographic method for determination of 2-hydroxymethyl-1-methyl-5-nitroimidazole (DMZOH), the hydroxy metabolite of dimetridazole, in swime muscle has been developed. The method uses cleanup steps similar to those of an earlier polarographic method. The present method is capable of quantitating levels as low as 2 ppb and detecting less than 1 ppb. Recoveries from 30 control tissues spiked at 1, 2, or 4 ppb averaged 80.4%. Performance of the method in incurred tissue was documented and limited data on the depletion of the metabolite in muscle were generated. The muscle of swine given 150 ppm dimetridazole in feed for 14 days contained less than 1 ppb DMZOH at 12 h withdrawal time. JF - Journal - Association of Official Analytical Chemists AU - Newkirk, D R AU - Righter, H F AU - Schenck, F J AU - Okrasinski, J L AU - Barnes, C J AD - Food and Drug Administration, Division of Chemistry, Rockville, MD 20857. PY - 1990 SP - 702 EP - 704 VL - 73 IS - 5 SN - 0004-5756, 0004-5756 KW - Indicators and Reagents KW - 0 KW - Solutions KW - Dimetridazole KW - K59P7XNB8X KW - Index Medicus KW - Swine KW - Animals KW - Chromatography, Gas KW - Muscles -- chemistry KW - Drug Residues -- analysis KW - Dimetridazole -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80211594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Gas+chromatographic+determination+of+incurred+dimetridazole+residues+in+swine+tissues.&rft.au=Newkirk%2C+D+R%3BRighter%2C+H+F%3BSchenck%2C+F+J%3BOkrasinski%2C+J+L%3BBarnes%2C+C+J&rft.aulast=Newkirk&rft.aufirst=D&rft.date=1990-09-01&rft.volume=73&rft.issue=5&rft.spage=702&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-28 N1 - Date created - 1991-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Repeated measures designs in behavioral toxicology: application to chronic marijuana smoke exposure. AN - 80142407; 2247030 AB - This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzing these types of studies. In particular, the standard univariate analysis most frequently used for repeated measures analyses has some very restrictive assumptions on the form of the covariance matrices. These assumptions are not met in the example discussed and are rarely met in many other problems. Other possible models for analyzing repeated measures when these assumptions are not met are presented and discussed. Other problems specific to the chronic marijuana smoke exposure study that may occur in similar type studies are presented. These include pooling the experimental units into groups with comparable baselines, choosing a function of the measures to be analyzed, dealing with a large data set with many observation times and missing data, unequal group sizes and different designs for different subsets of the experimental animals. The standard univariate repeated measures analysis was chosen to analyze the data even though the violations of the covariance assumptions may lead to finding differences that do not exist (Type I or false-positive errors), since the other methods presented also had covariance assumptions that were not met or had low power. Use of Bonferroni-type multiple comparisons on the single degree of freedom contrasts of interest hopefully reduced the chances of these false-positive results. JF - Neurotoxicology and teratology AU - Allen, R R AU - Slikker, W AU - Paule, M G AD - Computer Based Systems, Inc., Biometry Division, National Center for Toxicological Research, Jefferson, AR 72079-9502. PY - 1990 SP - 441 EP - 448 VL - 12 IS - 5 SN - 0892-0362, 0892-0362 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Data Interpretation, Statistical KW - Macaca mulatta KW - Models, Neurological KW - Longitudinal Studies KW - Time Factors KW - Research Design KW - Behavior, Animal -- drug effects KW - Marijuana Smoking -- adverse effects KW - Nervous System -- drug effects KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80142407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Repeated+measures+designs+in+behavioral+toxicology%3A+application+to+chronic+marijuana+smoke+exposure.&rft.au=Allen%2C+R+R%3BSlikker%2C+W%3BPaule%2C+M+G&rft.aulast=Allen&rft.aufirst=R&rft.date=1990-09-01&rft.volume=12&rft.issue=5&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-09 N1 - Date created - 1991-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monkey versus human performance in the NCTR Operant Test Battery. AN - 80142109; 2247039 AB - A battery of operant behavioral tasks, designed to monitor complex "cognitive" functions in monkeys, was adapted for use in children. Adaptations were then incorporated into the monkey battery so that monkeys and children performed exactly the same tasks. Food pellets served as reinforcers for monkeys; nickels for children. Correct responding in a task is thought to depend upon relatively specific brain functions including short-term memory and attention, learning, time perception, motivation, and color and position discrimination. Eight 4-year-old rhesus monkeys served as subjects, and groups (n = 10 to 20) of 4- to 8-year-old children were recruited if they were not known to have any neurological, academic or behavioral problems. In performance of only the learning task was there any significant difference between monkeys and children. This difference was in response rate (not accuracy), with the monkeys responding faster than children. This lone difference in operant responding between monkeys and children was likely due to the fact that monkeys generally use all four appendages to respond whereas children generally do not. JF - Neurotoxicology and teratology AU - Paule, M G AU - Forrester, T M AU - Maher, M A AU - Cranmer, J M AU - Allen, R R AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502. PY - 1990 SP - 503 EP - 507 VL - 12 IS - 5 SN - 0892-0362, 0892-0362 KW - Index Medicus KW - Discrimination Learning -- drug effects KW - Reaction Time -- drug effects KW - Animals KW - Motivation KW - Humans KW - Time Perception -- drug effects KW - Macaca mulatta KW - Child KW - Attention -- drug effects KW - Species Specificity KW - Memory, Short-Term -- drug effects KW - Child, Preschool KW - Conditioning, Operant -- drug effects KW - Cognition -- drug effects KW - Toxicology -- methods KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80142109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Monkey+versus+human+performance+in+the+NCTR+Operant+Test+Battery.&rft.au=Paule%2C+M+G%3BForrester%2C+T+M%3BMaher%2C+M+A%3BCranmer%2C+J+M%3BAllen%2C+R+R&rft.aulast=Paule&rft.aufirst=M&rft.date=1990-09-01&rft.volume=12&rft.issue=5&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-09 N1 - Date created - 1991-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of the NCTR Operant Test Battery in nonhuman primates. AN - 80138173; 2247027 AB - A battery of behavioral tasks, designed to monitor complex "cognitive" functions in nonhuman primates, has been in use for several years at the National Center for Toxicological Research. Subjects performing in this Operant Test Battery (OTB) work for food reinforcers and correct performance in each task contained in the OTB is thought to depend upon a relatively specific brain function. The specific tasks and the functions that they are thought to model are: delayed matching-to-sample (DMTS), short-term memory and attention; incremental repeated acquisition (IRA), learning; temporal response differentiation (TRD), time perception; progressive ratio (PR), motivation; and conditioned position responding (CPR), color and position discrimination. Data from various studies indicate that, in general: 1) OTB responding between subjects follows a normal or near-normal distribution; 2) performance in one task does not correlate very highly with performance in any of the other tasks; 3) females acquire correct OTB responding more rapidly than do males; and 4) the profile of disruption of task performance by acute drug administration varies depending upon drug class. JF - Neurotoxicology and teratology AU - Paule, M G AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502. PY - 1990 SP - 413 EP - 418 VL - 12 IS - 5 SN - 0892-0362, 0892-0362 KW - Index Medicus KW - Discrimination Learning -- drug effects KW - Animals KW - Sex Factors KW - Motivation KW - Time Perception -- drug effects KW - Learning -- drug effects KW - Memory, Short-Term -- drug effects KW - Male KW - Female KW - Conditioning, Operant -- drug effects KW - Toxicology -- methods KW - Neuropsychological Tests KW - Macaca mulatta -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80138173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Use+of+the+NCTR+Operant+Test+Battery+in+nonhuman+primates.&rft.au=Paule%2C+M+G&rft.aulast=Paule&rft.aufirst=M&rft.date=1990-09-01&rft.volume=12&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-09 N1 - Date created - 1991-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Herpes simplex virus in postradiation cervical smears. A morphologic and immunocytochemical study. AN - 80064127; 1699373 AB - From January 1987 to August 1988, cytomorphologic criteria of both herpes simplex virus (HSV) and radiation effects were observed in Papanicolaou smears from 3 of 1,340 patients who had received radiotherapy for squamous cell carcinoma of the cervix. Avidin-biotin immunoperoxidase staining, using a rabbit IgG polyclonal HSV antibody, confirmed the presence of HSV antigen in those three postradiation smears. Both multinucleated molded cells and epithelial cells that lacked cytopathic effects were positive for HSV. Three other postradiation smears from these cases were similarly positive for HSV antigen; the one preradiation smear was negative. In situ hybridization and immunoperoxidase studies on sections from the preradiation biopsies were negative: severely altered neoplastic cells showed no reactivity. The absence of HSV markers in the preradiation specimens suggests that the HSV infections were secondary to the radiotherapy; further studies are needed to prove this association and to assess the possible mechanisms. These cases clearly indicate that the overlapping features of radiation and viral effects (such as multinucleation) may be present simultaneously. JF - Acta cytologica AU - Longatto Filho, A AU - Maeda, M Y AU - Oyafuso, M S AU - Kanamura, C T AU - Alves, V A AD - Division of Pathology, Adolfo Lutz Institute, São Paulo State Public Health Service, Brazil. PY - 1990 SP - 652 EP - 656 VL - 34 IS - 5 SN - 0001-5547, 0001-5547 KW - Index Medicus KW - Simplexvirus -- isolation & purification KW - Epithelium -- microbiology KW - Humans KW - Adult KW - Vaginal Smears KW - Middle Aged KW - Epithelium -- radiation effects KW - Epithelium -- pathology KW - Staining and Labeling KW - Immunoenzyme Techniques KW - Female KW - Papanicolaou Test KW - Herpes Genitalis -- etiology KW - Cervix Uteri -- pathology KW - Herpes Genitalis -- pathology KW - Cervix Uteri -- microbiology KW - Radiation Injuries -- microbiology KW - Cervix Uteri -- radiation effects KW - Radiation Injuries -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80064127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+cytologica&rft.atitle=Herpes+simplex+virus+in+postradiation+cervical+smears.+A+morphologic+and+immunocytochemical+study.&rft.au=Longatto+Filho%2C+A%3BMaeda%2C+M+Y%3BOyafuso%2C+M+S%3BKanamura%2C+C+T%3BAlves%2C+V+A&rft.aulast=Longatto+Filho&rft.aufirst=A&rft.date=1990-09-01&rft.volume=34&rft.issue=5&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Acta+cytologica&rft.issn=00015547&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo administration of interferon alpha and interleukin 2 induces proliferation of lymphoid cells in the organs of mice. AN - 79947278; 2386960 AB - We have previously shown that interleukin 2 (IL-2) synergizes with interferon alpha (IFN-alpha) in mediating the regression of established pulmonary and hepatic metastases and the reduction of intradermal tumor in various murine tumor models. To understand the mechanism of synergy, we have examined lymphoid cell proliferation in various organs of mice in response to IL-2 and IFN-alpha administration. We have utilized a technique for labeling newly synthesized DNA in vivo with 5-[125I]iodo-2'-deoxyuridine to examine proliferation of endogenous cells in response to IL-2 and IL-2 plus IFN-alpha. A proliferation index was calculated by dividing cpm in the tissues treated with cytokines by cpm obtained in corresponding tissues of control mice. After 4 days of IL-2 administration, a significant uptake of 5-[125I]iodo-2'-deoxyuridine was observed in the lungs, liver, kidneys, and spleen (proliferation index of 13, 10.3, 3.6, and 3.2, respectively). IFN-alpha alone mediated very little incorporation of radiolabel but when administered in combination with IL-2 a reduction of IL-2-induced proliferation was seen on day 4. For example 19,272 +/- 4,556 cpm (mean +/- SE) were obtained in the liver of IL-2-treated mice, compared to 8,103 +/- 2,111 cpm in livers of IL-2 plus IFN-alpha-treated mice (P less than 0.05). Similar inhibition of IL-2-induced proliferation was observed in the lungs, kidneys, and spleen. In contrast, on days 7 or 8, higher uptake of radiolabel was obtained in IFN-alpha plus IL-2-treated lungs, liver, and kidneys, compared to organs of mice treated with IL-2 alone or IFN-alpha alone. A proliferation index of 30.5, 9.8, and 10 was obtained in the lungs, liver, and kidneys of IL-2- plus IFN-alpha-treated animals, compared to 9.6, 3.6, and 5.5 in the corresponding organs of IL-2-treated mice. The effects of IFN-alpha on IL-2-induced proliferation was dose dependent; very low dosages of IFN-alpha (1,000 units/dose) were able to cause the inhibition of proliferation at 3 days of therapy and increase at 7 days of therapy. Continued proliferation of cells was observed in most organs when IL-2 plus IFN-alpha was injected for 9 consecutive days. Pretreatment irradiation of mice at 500 rad largely eliminated the proliferative response to IL-2 as well as to IFN-alpha plus IL-2 at both 3 and 7 days. Histological studies of lungs receiving cytokine therapy for 3 and 7 days corroborated the results of the 5-[125I]iodo-2'-deoxyuridine incorporation assay. At day 3 a significant infiltration of lymphoid cells was seen in IL-2-treated lungs, whereas little or no lymphocytic infiltration was observed in IL-2- plus IFN-alpha-treated lungs.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cancer research AU - Puri, R K AU - Travis, W D AU - Rosenberg, S A AD - Division of Cytokine Biology, CBER, FDA, Bethesda, MD 20892. Y1 - 1990/09/01/ PY - 1990 DA - 1990 Sep 01 SP - 5543 EP - 5550 VL - 50 IS - 17 SN - 0008-5472, 0008-5472 KW - Interferon Type I KW - 0 KW - Interleukin-2 KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Reference Values KW - Drug Interactions KW - Recombinant Proteins -- pharmacology KW - Kinetics KW - Mice, Inbred C57BL KW - Cell Division -- drug effects KW - Mice KW - Female KW - Interleukin-2 -- pharmacology KW - Liver -- cytology KW - Liver -- drug effects KW - Interferon Type I -- pharmacology KW - Lung -- cytology KW - Lymphocytes -- radiation effects KW - Lung -- drug effects KW - Lymphocytes -- cytology KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79947278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=In+vivo+administration+of+interferon+alpha+and+interleukin+2+induces+proliferation+of+lymphoid+cells+in+the+organs+of+mice.&rft.au=Puri%2C+R+K%3BTravis%2C+W+D%3BRosenberg%2C+S+A&rft.aulast=Puri&rft.aufirst=R&rft.date=1990-09-01&rft.volume=50&rft.issue=17&rft.spage=5543&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-27 N1 - Date created - 1990-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - GEN T1 - Health Careers Opportunity Program (HCOP). Section 787 (Public Health Service Act). Program Guide. AN - 62997251; ED329167 AB - This document summarizes the requirements and guidelines for the Health Careers Opportunity Program (HCOP). This program is authorized by Section 787 of the Public Health Service Act to make grants to and contracts with postsecondary institutions to carry out programs which assist individuals from disadvantaged backgrounds to enter and graduate from health and allied health profession schools. Eligible institutions include schools of allopathic medicine, osteopathic medicine, public health, dentistry, veterinary medicine, optometry, pharmacy, allied health, chiropractic and podiatric medicine, and public and nonprofit private schools that offer graduate programs in clinical psychology. Of the funds appropriated, 20% must be obligated for stipends to disadvantaged individuals of exceptional financial need, 10% for community-based programs, and 70% for grants or contracts to institutions of higher education. This document describes eligible applicants, eligible professions, eligible student participants, definitions, HCOP purposes, funding priorities and preferences, administration, deadlines, grant start dates, review process and criteria, types of applications, program director/project director responsibilities, use of grant funds, indirect costs, method of payment, reports, audits, and regulations. (JDD) Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 23 KW - Health Careers Opportunity Program KW - ERIC, Resources in Education (RIE) KW - Professional Personnel KW - Educational Opportunities KW - Program Implementation KW - Federal Programs KW - Economically Disadvantaged KW - Disadvantaged KW - Professional Education KW - Health Personnel KW - Affirmative Action KW - Higher Education KW - Health Occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62997251?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Pages 22 and 23 will not reproduce clearly due to N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Primary care research: an agenda for the 90s T2 - Dept. of Health and Human Services. DHHS pubn. no. (PHS)90-3460 AN - 59544277; 1991-0308142 AB - Current status and future directions of selected areas. Proceedings of a conference sponsored by the Agency for Health Care and Policy Research, held in Colorado Springs, Colorado, Mar. 28-30, 1990. Topics include changing physician behavior, mental disorders, research on primary care and rural health, practice-based networks, AIDS, and other aspects of the primary care setting. JF - Nat Tech Info Service, September 1990. vi+147 pp. AU - Mayfield, Jennifer AU - Grady, Mary L Y1 - 1990/09// PY - 1990 DA - September 1990 EP - vi+147 PB - Nat Tech Info Service KW - United States -- Health policy KW - Medical research -- United States KW - Medical service -- United States KW - Community health services -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59544277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mayfield%2C+Jennifer%3BGrady%2C+Mary+L&rft.aulast=Mayfield&rft.aufirst=Jennifer&rft.date=1990-09-01&rft.volume=&rft.issue=&rft.spage=vi%2B147&rft.isbn=&rft.btitle=Primary+care+research%3A+an+agenda+for+the+90s&rft.title=Primary+care+research%3A+an+agenda+for+the+90s&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Nat Tech Info Service pa N1 - Document feature - il(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Use of home and community services by persons ages 65 and older with functional difficulties T2 - Nat. Med. Expenditure Survey research findings 5 Dept. of Health and Human Services. DHHS pubn. no. (PHS)90-3466 AN - 59537522; 1991-0300742 AB - Based on 1987 data. Includes adult day care, special transportation, telephone monitoring, congregate meals, and home meals. JF - Nat Tech Info Service, September 1990. 18 pp. AU - Short, P F AU - Leon, J Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 18 PB - Nat Tech Info Service KW - Community health services -- Use KW - Old age -- United States KW - United States -- Health policy KW - Day care centers for the aged -- Use KW - Old age -- Home care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59537522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Short%2C+P+F%3BLeon%2C+J&rft.aulast=Short&rft.aufirst=P&rft.date=1990-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+home+and+community+services+by+persons+ages+65+and+older+with+functional+difficulties&rft.title=Use+of+home+and+community+services+by+persons+ages+65+and+older+with+functional+difficulties&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Nat Tech Info Service $15 N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Selected bibliography on AIDS for health services research T2 - AHCPR program note AN - 59536093; 1991-0300780 AB - Community-based care, costs, financing, and insurance, public health, planning, and policy, and other topics; articles published Aug. 1989-Aug. 1990; with abstracts. JF - Room 18-12, Parklawn Bldg., Rockville, MD 20857, September 1990. vii+96 pp. AU - Siegel, Randie A AU - Rudzinski, Karen A Y1 - 1990/09// PY - 1990 DA - September 1990 EP - vii+96 PB - Room 18-12, Parklawn Bldg., Rockville, MD 20857 KW - Acquired immune deficiency syndrome -- United States -- Bibliography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59536093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Siegel%2C+Randie+A%3BRudzinski%2C+Karen+A&rft.aulast=Siegel&rft.aufirst=Randie&rft.date=1990-09-01&rft.volume=&rft.issue=&rft.spage=vii%2B96&rft.isbn=&rft.btitle=Selected+bibliography+on+AIDS+for+health+services+research&rft.title=Selected+bibliography+on+AIDS+for+health+services+research&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., Rockville, MD 20857; Nat Tech Info Service pa $23 N1 - Document feature - bibl(s), index(es) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Bovine growth hormone: human food safety evaluation. AN - 79970258; 2203142 AB - Scientists in the Food and Drug Administration (FDA), after reviewing the scientific literature and evaluating studies conducted by pharmaceutical companies, have concluded that the use of recombinant bovine growth hormone (rbGH) in dairy cattle presents no increased health risk to consumers. Bovine GH is not biologically active in humans, and oral toxicity studies have demonstrated that rbGH is not orally active in rats, a species responsive to parenterally administered bGH. Recombinant bGH treatment produces an increase in the concentration of insulin-like growth factor-I (IGF-I) in cow's milk. However, oral toxicity studies have shown that bovine IGF-I lacks oral activity in rats. Additionally, the concentration of IGF-I in milk of rbGH-treated cows is within the normal physiological range found in human breast milk, and IGF-I is denatured under conditions used to process cow's milk for infant formula. On the basis of estimates of the amount of protein absorbed intact in humans and the concentration of IGF-I in cow's milk during rbGH treatment, biologically significant levels of intact IGF-I would not be absorbed. JF - Science (New York, N.Y.) AU - Juskevich, J C AU - Guyer, C G AD - Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD 20857. Y1 - 1990/08/24/ PY - 1990 DA - 1990 Aug 24 SP - 875 EP - 884 VL - 249 IS - 4971 SN - 0036-8075, 0036-8075 KW - Recombinant Proteins KW - 0 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Growth Hormone KW - 9002-72-6 KW - Index Medicus KW - United States KW - Animals KW - Insulin-Like Growth Factor I -- physiology KW - Cattle KW - United States Food and Drug Administration KW - Humans KW - Recombinant Proteins -- standards KW - Growth Hormone -- standards KW - Growth Hormone -- physiology KW - Growth Hormone -- pharmacology KW - Food -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79970258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Bovine+growth+hormone%3A+human+food+safety+evaluation.&rft.au=Juskevich%2C+J+C%3BGuyer%2C+C+G&rft.aulast=Juskevich&rft.aufirst=J&rft.date=1990-08-24&rft.volume=249&rft.issue=4971&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-01 N1 - Date created - 1990-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Science. 1990 Aug 24;249(4971):852-3 [2392675] Science. 1991 Jan 18;251(4991):256-7 [1987638] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pharmacologically guided phase I clinical trials based upon preclinical drug development. AN - 79923286; 2143234 AB - Since our original proposal 4 years ago, considerable support has evolved for the concept of pharmacologically guided dose escalation in phase I clinical trials with new anticancer drugs. The original focus has been broadened to develop additional links between preclinical testing and phase I clinical trials. Recent experiences with very lengthy phase I trials for at least eight drugs have provided particular impetus for this project. The original pharmacodynamic hypothesis for the proposal was equal toxicity at equal plasma levels. Specifically, two facets of the concept were that (a) dose-limiting toxicity correlates with, and in turn is predicted by, drug concentrations in plasma and (b) that the quantitative relationship between toxicity and drug exposure, as measured by plasma drug concentration times time (C x T), holds across species. If true, this hypothesis would suggest that dose escalations in humans could be safely based on measurement of drug levels in plasma, rather than on empirical escalation schemes. In addition to the collection of a larger retrospective data base to validate this hypothesis, practical results have already been achieved. In two studies sponsored by the National Cancer Institute (NCI), the escalation pattern was prospectively modified on the basis of measurements of drug levels in plasma. In addition, for three NCI-sponsored drugs, more careful matching of schedules between clinical and preclinical testing produced entry doses that were up to 25 times higher than doses used in standard procedures. Consequently, the phase I trials for each drug were completed with a savings of 12-24 months. As a result of work in both the United States and Europe, a substantial collection of data now demonstrates that coordination with preclinical pharmacology and toxicology studies can save both time and resources in early clinical trials without a loss of safety. JF - Journal of the National Cancer Institute AU - Collins, J M AU - Grieshaber, C K AU - Chabner, B A AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/08/15/ PY - 1990 DA - 1990 Aug 15 SP - 1321 EP - 1326 VL - 82 IS - 16 SN - 0027-8874, 0027-8874 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Humans KW - Mice KW - Time Factors KW - Species Specificity KW - Meta-Analysis as Topic KW - Drug Screening Assays, Antitumor KW - Drug Evaluation -- methods KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- toxicity KW - Antineoplastic Agents -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79923286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Pharmacologically+guided+phase+I+clinical+trials+based+upon+preclinical+drug+development.&rft.au=Collins%2C+J+M%3BGrieshaber%2C+C+K%3BChabner%2C+B+A&rft.aulast=Collins&rft.aufirst=J&rft.date=1990-08-15&rft.volume=82&rft.issue=16&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-10 N1 - Date created - 1990-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 79895148; 2197448 JF - JAMA AU - Nightingale, S L AD - Office of Health Affairs, FDA, Rockville, MD 20857. Y1 - 1990/08/08/ PY - 1990 DA - 1990 Aug 08 SP - 677 VL - 264 IS - 6 SN - 0098-7484, 0098-7484 KW - BCG Vaccine KW - 0 KW - Drugs, Investigational KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - United States KW - Drugs, Investigational -- therapeutic use KW - United States Food and Drug Administration KW - Combined Modality Therapy KW - Humans KW - Clinical Trials as Topic KW - Policy Making KW - Colonic Neoplasms -- therapy KW - Aspirin -- adverse effects KW - Urinary Bladder Neoplasms -- therapy KW - Carcinoma in Situ -- therapy KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Drug Labeling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79895148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1990-08-08&rft.volume=264&rft.issue=6&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-24 N1 - Date created - 1990-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of two independent mechanisms by which interferon-induced gene expression is down regulated. AN - 80290510; 2127700 AB - Interferons (IFNs) induce the expression of a variety of cellular RNAs. Phorbol esters can inhibit IFN-induced expression of some of these RNAs, including ISG-54K. The actions of phorbol esters on IFN-activated ISG-54K transcription are cell specific and are reversed by inhibitors of protein synthesis. In those cell lines in which phorbol esters inhibit IFN-induced ISG-54K transcription, prolonged IFN exposure also induces a "desensitized state" such that further IFN exposure no longer induces ISG-54K expression. IFN-induced desensitization is also reversed by inhibitors of protein synthesis. Experiments are described to determine whether the mechanism by which phorbol esters inhibit IFN-activated ISG-54K expression is the same as the mechanism by which prolonged exposure to IFN makes cells refractory to further induction of ISG-54K expression. Cultured cells treated with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 72 h are desensitized to phorbol esters such that further addition of phorbols does not inhibit IFN-induced ISG-54K expression. In both naive and TPA-desensitized human fibroblasts or WISH cells, prolonged IFN treatment induced a desensitized state that was reversible by cycloheximide. This observation suggests that the mechanisms by which prolonged IFN treatment and phorbol esters inhibit ISG-54K expression are independent. JF - Cell regulation AU - Akai, H AU - Larner, A C AD - Laboratory of Cytokine Research, Center for Biologics Evaluation and Research, National Institutes of Health, Bethesda, Maryland 20892. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 707 EP - 713 VL - 1 IS - 9 SN - 1044-2030, 1044-2030 KW - ISG-54K KW - Phorbol Esters KW - 0 KW - Protein Synthesis Inhibitors KW - RNA Probes KW - RNA, Antisense KW - Recombinant Proteins KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Phorbol Esters -- pharmacology KW - Protein Synthesis Inhibitors -- pharmacology KW - Cells, Cultured KW - Kinetics KW - Humans KW - Transcription, Genetic KW - Interferon-gamma -- antagonists & inhibitors KW - Interferon-gamma -- pharmacology KW - Gene Expression Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80290510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+regulation&rft.atitle=Characterization+of+two+independent+mechanisms+by+which+interferon-induced+gene+expression+is+down+regulated.&rft.au=Akai%2C+H%3BLarner%2C+A+C&rft.aulast=Akai&rft.aufirst=H&rft.date=1990-08-01&rft.volume=1&rft.issue=9&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Cell+regulation&rft.issn=10442030&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-01 N1 - Date created - 1991-05-01 N1 - Date revised - 2017-01-13 N1 - Gene symbol - ISG-54K N1 - SuppNotes - Cited By: Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Cell. 1989 Nov 3;59(3):405-8 [2572326] Cell. 1984 Oct;38(3):745-55 [6548414] Proc Natl Acad Sci U S A. 1984 Nov;81(21):6733-7 [6436820] Nature. 1985 Jun 20-26;315(6021):672-6 [3925348] Cell. 1985 Nov;43(1):243-51 [3000601] J Biol Chem. 1986 Jan 5;261(1):453-9 [2934388] Proc Natl Acad Sci U S A. 1986 Jan;83(2):357-60 [3455773] Proc Natl Acad Sci U S A. 1986 Oct;83(20):7765-9 [2945205] Science. 1986 Oct 17;234(4774):355-8 [2429366] Proc Natl Acad Sci U S A. 1986 Dec;83(23):8929-33 [3466167] J Biol Chem. 1987 Jan 5;262(1):234-8 [3491822] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9453-7 [3540941] Mol Cell Biol. 1987 Jun;7(6):2256-66 [3037355] Annu Rev Biochem. 1987;56:727-77 [2441659] Proc Natl Acad Sci U S A. 1987 Sep;84(18):6394-8 [3476954] Nature. 1987 Oct 15-21;329(6140):648-51 [2821407] Mol Cell Biol. 1987 Oct;7(10):3490-502 [3119989] Genes Dev. 1988 Apr;2(4):383-93 [3371658] Proc Natl Acad Sci U S A. 1988 Jul;85(14):5122-5 [3134657] J Biol Chem. 1989 Feb 25;264(6):3252-5 [2464596] Proc Natl Acad Sci U S A. 1989 Mar;86(6):1973-6 [2494657] Proc Natl Acad Sci U S A. 1989 Apr;86(7):2243-7 [2538838] J Biol Chem. 1989 Aug 25;264(24):14305-11 [2474543] Nucleic Acids Res. 1984 Sep 25;12(18):6951-63 [6548307] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Platelet-activating factor-induced aggregation of rat alveolar macrophages. AN - 79985109; 2396044 AB - Isolated rat alveolar macrophages aggregate in the presence of PAF in a dose- and cell-dependent manner. Saturation was achieved at 80 microM PAF. The response was increased linearly with cell number up to a concentration of 3 x 10(6) cells/ml, but decreased at higher cell concentrations. The stereoisomer, enantio-PAF, and the C2-acetyl hydrolyzed product, lyso-PAF, each caused aggregation of isolated rat alveolar macrophages in a manner similar to that for PAF. The PAF-induced aggregation of alveolar macrophages may be mediated through non-specific binding sites and may represent a toxic response to relatively high levels of PAF that released at localized sites. JF - Research communications in chemical pathology and pharmacology AU - Rabovsky, J AU - Goddard, M AU - Pailes, W H AU - Judy, D J AU - Castranova, V AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 163 EP - 172 VL - 69 IS - 2 SN - 0034-5164, 0034-5164 KW - O-deacetyl platelet activating factor KW - 0 KW - Platelet Activating Factor KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Stereoisomerism KW - In Vitro Techniques KW - Pulmonary Alveoli -- drug effects KW - Pulmonary Alveoli -- cytology KW - Male KW - Platelet Activating Factor -- pharmacology KW - Cell Aggregation -- drug effects KW - Platelet Activating Factor -- analogs & derivatives KW - Macrophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79985109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Platelet-activating+factor-induced+aggregation+of+rat+alveolar+macrophages.&rft.au=Rabovsky%2C+J%3BGoddard%2C+M%3BPailes%2C+W+H%3BJudy%2C+D+J%3BCastranova%2C+V&rft.aulast=Rabovsky&rft.aufirst=J&rft.date=1990-08-01&rft.volume=69&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-11 N1 - Date created - 1990-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital. AN - 79948800; 2387015 AB - The ability of the dietary methyl donors methionine and choline to inhibit the carcinogenic and tumor-promoting effects of phenobarbital (PB) in the livers of male weanling C3H mice was examined. The mice were fed a commercial rodent diet with or without 0.05% PB. Thirty animals from each set received the diet with either: (1) no dietary supplementation, (2) an additional 1.0% choline chloride, (3) 1.5% DL-methionine or (4) both 1.5% DL-methionine and 1.0% choline chloride. Additional groups of 30 animals with the same eight dietary and PB-treatment regimens described above were given a single initiating dose of 150 mg diethylnitrosamine (DENA)/kg body wt dissolved in saline, or the saline solution only, 1 week prior to the start of PB feeding. The 16 treatment groups were fed their respective diets for 12 months. Statistical trend analysis showed that increasing levels of supplemental methyl donors gave highly significant protection in PB-treated mice (P less than 0.01). The incidence of liver carcinomas in the four dietary groups not receiving PB or DENA varied from 0 to 7%. The PB-treated animals not receiving an initiating dose of DENA developed hepatocellular carcinomas (HCCs) at incidences of 79% in group 1 animals, 74% in group 2 animals, 60% in group 3 animals, and 31% in group 2 animals respectively. Thus, incidence of HCCs in group 4 was significantly lower than in groups 1, 2 or 3 (P less than 0.01). However, the total incidence of liver tumors (adenomas plus carcinomas) was about the same in all DENA or PB-treated groups. Thus, dietary supplementation with methyl donors increased the proportion of animals bearing liver adenomas as their most advanced hepatic lesion in PB-treated mice. In DENA-treated mice fed PB, dietary supplementation with methionine and choline protected against the formation of liver carcinomas (P less than 0.02); however, methionine and choline had no significant effect on liver tumor formation in mice fed the PB-free diets. Methionine and choline supplementation gave significant protection against HCC metastases in the lungs of the tumor-bearing mice in groups initiated with DENA followed by PB promotion. These results support the hypothesis that PB exerts it tumorigenic activity in mice at least in part through a physiological insufficiency of labile methyl groups. JF - Carcinogenesis AU - Fullerton, F R AU - Hoover, K AU - Mikol, Y B AU - Creasia, D A AU - Poirier, L A AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 1301 EP - 1305 VL - 11 IS - 8 SN - 0143-3334, 0143-3334 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Methionine KW - AE28F7PNPL KW - Choline KW - N91BDP6H0X KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Liver -- drug effects KW - Neoplasm Metastasis KW - Mice, Inbred C3H KW - Mice KW - Male KW - Organ Size -- drug effects KW - Choline -- pharmacology KW - Liver Neoplasms, Experimental -- chemically induced KW - Methionine -- pharmacology KW - Phenobarbital -- toxicity KW - Liver Neoplasms, Experimental -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79948800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+inhibition+by+methionine+and+choline+of+liver+carcinoma+formation+in+male+C3H+mice+dosed+with+diethylnitrosamine+and+fed+phenobarbital.&rft.au=Fullerton%2C+F+R%3BHoover%2C+K%3BMikol%2C+Y+B%3BCreasia%2C+D+A%3BPoirier%2C+L+A&rft.aulast=Fullerton&rft.aufirst=F&rft.date=1990-08-01&rft.volume=11&rft.issue=8&rft.spage=1301&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-27 N1 - Date created - 1990-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen. AN - 79933738; 2200409 AB - The hepatotoxicity of acetaminophen correlates with the formation of 3-(cystein-S-yl)acetaminophen protein adducts. Using a sensitive and specific immunochemical assay, we quantitated the formation of these protein adducts in liver fractions and serum after administration of a hepatotoxic dose of acetaminophen (400 mg/kg) to B6C3F1 mice. Adducts in the cytosolic fraction increased to 3.6 nmol/mg protein at 2 hr and then decreased to 1.1 nmol/mg protein by 8 hr. Concomitant with the decrease in adducts in the cytosol, 3-(cystein-S-yl)acetaminophen protein adducts appeared in serum and their levels paralleled increases in serum alanine aminotransferase. Microsomal protein adducts peaked at 1 hr (0.7 nmol/mg protein) and subsequently decreased to 0.2 nmol/mg at 8 hr. The 4000 g pellet (nuclei, plasma membranes, and cell debris) had the highest level of adducts (3.5 nmol/mg protein), which remained constant from 1 to 8 hr. Evaluation of fractions purified from a 960 g pellet indicated that the highest concentration of 3-(cystein-S-yl)acetaminophen protein adducts was located in plasma membranes and mitochondria; peak levels were 10.3 and 5.1 nmol/mg respectively. 3-(Cystein-S-yl)acetaminophen protein adducts were detected in nuclei only after enzymatic hydrolysis of the proteins. The localization of high levels of 3-(cystein-S-yl)acetaminophen protein adducts in plasma membranes and mitochondria may play a critical role in acetaminophen toxicity. JF - Biochemical pharmacology AU - Pumford, N R AU - Roberts, D W AU - Benson, R W AU - Hinson, J A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1990/08/01/ PY - 1990 DA - 1990 Aug 01 SP - 573 EP - 579 VL - 40 IS - 3 SN - 0006-2952, 0006-2952 KW - Benzoquinones KW - 0 KW - Imines KW - Quinones KW - acetaminophen-cysteine conjugate KW - Acetaminophen KW - 362O9ITL9D KW - Alanine Transaminase KW - EC 2.6.1.2 KW - N-acetyl-4-benzoquinoneimine KW - G6S9BN13TI KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Cell Nucleus -- metabolism KW - Mitochondria, Liver -- metabolism KW - Microsomes, Liver -- metabolism KW - Chemical and Drug Induced Liver Injury KW - Mice KW - Quinones -- pharmacology KW - Imines -- pharmacology KW - Quinones -- metabolism KW - Alanine Transaminase -- blood KW - Kinetics KW - Cell Membrane -- metabolism KW - Fluorescent Antibody Technique KW - Imines -- metabolism KW - Male KW - Liver -- ultrastructure KW - Acetaminophen -- blood KW - Acetaminophen -- analysis KW - Cysteine -- metabolism KW - Cysteine -- analysis KW - Cysteine -- blood KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79933738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Immunochemical+quantitation+of+3-%28cystein-S-yl%29acetaminophen+protein+adducts+in+subcellular+liver+fractions+following+a+hepatotoxic+dose+of+acetaminophen.&rft.au=Pumford%2C+N+R%3BRoberts%2C+D+W%3BBenson%2C+R+W%3BHinson%2C+J+A&rft.aulast=Pumford&rft.aufirst=N&rft.date=1990-08-01&rft.volume=40&rft.issue=3&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-11 N1 - Date created - 1990-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of occupational asthma from airborne egg protein exposure in multiple settings. AN - 79904904; 2376172 AB - We previously reported IgE-mediated occupational asthma among workers exposed to airborne egg protein at a plant that produces liquid and dried powdered egg products. To demonstrate that our original observations are generalizable to other facilities that process eggs, and to estimate the prevalence of IgE-mediated occupational asthma among egg-exposed workers, we conducted surveys at two additional plants. We administered a questionnaire to 188 employees to identify workers with symptoms suggestive of occupational asthma. We further evaluated 88 workers with and without symptoms by a clinical examination by a physician blinded to results of other tests, serial peak expiratory flow rate (PEFR) determinations every three hours while awake for one week, and skin prick tests and serum specific IgE levels to extracts of factory egg products, commercial egg test reagents, and egg white protein fractions. Fourteen workers had work-related asthmalike symptoms by questionnaire, a physician diagnosis of occupational asthma, and evidence of IgE-mediated sensitization to one or more egg proteins. Workers exposed exclusively to liquid egg aerosol, as well as workers exposed primarily to dried airborne egg protein, developed occupational asthma. This study replicated our original observations and demonstrated that workers in all areas of liquid and powdered egg production are at risk of developing occupational asthma from exposure to airborne egg proteins. JF - Chest AU - Smith, A B AU - Bernstein, D I AU - London, M A AU - Gallagher, J AU - Ornella, G A AU - Gelletly, S K AU - Wallingford, K AU - Newman, M A AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 398 EP - 404 VL - 98 IS - 2 SN - 0012-3692, 0012-3692 KW - Air Pollutants, Occupational KW - 0 KW - Egg Proteins KW - Immunoglobulin E KW - 37341-29-0 KW - Abridged Index Medicus KW - Index Medicus KW - Radioallergosorbent Test KW - Animals KW - Immunoglobulin E -- immunology KW - Peak Expiratory Flow Rate KW - Skin Tests KW - Risk Factors KW - Humans KW - Data Collection KW - United States -- epidemiology KW - Prevalence KW - Asthma -- epidemiology KW - Asthma -- etiology KW - Egg Proteins -- adverse effects KW - Eggs -- adverse effects KW - Air Pollutants, Occupational -- adverse effects KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79904904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Evaluation+of+occupational+asthma+from+airborne+egg+protein+exposure+in+multiple+settings.&rft.au=Smith%2C+A+B%3BBernstein%2C+D+I%3BLondon%2C+M+A%3BGallagher%2C+J%3BOrnella%2C+G+A%3BGelletly%2C+S+K%3BWallingford%2C+K%3BNewman%2C+M+A&rft.aulast=Smith&rft.aufirst=A&rft.date=1990-08-01&rft.volume=98&rft.issue=2&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-04 N1 - Date created - 1990-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Chest. 1990 Aug;98(2):261-2 [2376154] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of vitamin A toxicity. AN - 79900802; 2197848 AB - Toxicity has been associated with abuse of vitamin A supplements and with diets extremely high in preformed vitamin A. Consumption of 25,000-50,000 IU/d for periods of several months or more can produce multiple adverse effects. The lowest reported intakes causing toxicity have occurred in persons with liver function compromised by drugs, viral hepatitis, or protein-energy malnutrition. Certain drugs or other chemicals may markedly potentiate vitamin A toxicity in animals. Especially vulnerable groups include children, with adverse effects occurring with intakes as low as 1,500 IU.kg-1.d-1, and pregnant women, with birth defects being associated with maternal intakes as low as approximately 25,000 IU/d. The maternal dose threshold for birth defects cannot be identified from present data. An identifiable fraction of the population surveyed consumes vitamin A supplements at 25,000 IU/d and a few individuals consume much more. beta-Carotene is much less toxic than vitamin A. JF - The American journal of clinical nutrition AU - Hathcock, J N AU - Hattan, D G AU - Jenkins, M Y AU - McDonald, J T AU - Sundaresan, P R AU - Wilkening, V L AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 183 EP - 202 VL - 52 IS - 2 SN - 0002-9165, 0002-9165 KW - beta Carotene KW - 01YAE03M7J KW - Vitamin A KW - 11103-57-4 KW - Carotenoids KW - 36-88-4 KW - Abridged Index Medicus KW - Index Medicus KW - Carotenoids -- toxicity KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Abnormalities, Drug-Induced -- etiology KW - Drug Synergism KW - Carotenoids -- metabolism KW - Carotenoids -- adverse effects KW - Liver Diseases -- metabolism KW - Vitamin A -- adverse effects KW - Vitamin A -- administration & dosage KW - Vitamin A -- toxicity KW - Hypervitaminosis A -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79900802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Evaluation+of+vitamin+A+toxicity.&rft.au=Hathcock%2C+J+N%3BHattan%2C+D+G%3BJenkins%2C+M+Y%3BMcDonald%2C+J+T%3BSundaresan%2C+P+R%3BWilkening%2C+V+L&rft.aulast=Hathcock&rft.aufirst=J&rft.date=1990-08-01&rft.volume=52&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-24 N1 - Date created - 1990-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Labetalol hepatotoxicity. AN - 79898036; 2375555 AB - The Food and Drug Administration has received 11 reports of cases (three fatal) in the United States in which hepatocellular damage was associated with labetalol. The temporal circumstances strongly implicate labetalol; the conditions of nine patients improved after cessation of labetalol therapy, and one patient had a recurrence after therapy was restarted. Follow-up with each reporting physician failed to provide historic or laboratory evidence for other viral, toxic, or drug-induced causes of hepatocellular damage, and the case series did not show the demographic and historic risk factors that would be expected if non-A, non-B hepatitis were the cause. Reports of microscopic liver examinations were available in the 5 cases in which they were done. The reported histologic changes were consistent with hepatocellular necrosis in four instances and chronic active hepatitis in one. The clinical presentation of the cases was most compatible with the mechanism of metabolic idiosyncracy, but other pathogenetic explanations could not be entirely excluded. JF - Annals of internal medicine AU - Clark, J A AU - Zimmerman, H J AU - Tanner, L A AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1990/08/01/ PY - 1990 DA - 1990 Aug 01 SP - 210 EP - 213 VL - 113 IS - 3 SN - 0003-4819, 0003-4819 KW - Labetalol KW - R5H8897N95 KW - Abridged Index Medicus KW - Index Medicus KW - Necrosis KW - Liver -- pathology KW - Diagnosis, Differential KW - Hepatitis, Viral, Human -- diagnosis KW - Humans KW - Liver Diseases -- pathology KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Liver Diseases -- diagnosis KW - Female KW - Chemical and Drug Induced Liver Injury KW - Labetalol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79898036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Labetalol+hepatotoxicity.&rft.au=Clark%2C+J+A%3BZimmerman%2C+H+J%3BTanner%2C+L+A&rft.aulast=Clark&rft.aufirst=J&rft.date=1990-08-01&rft.volume=113&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-27 N1 - Date created - 1990-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 1991 Feb 15;114(4):341 [2018583] Erratum In: Ann Intern Med 1990 Sep 15;113(6):485 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Post-transcriptional regulation of granulocyte-macrophage colony-stimulating factor synthesis in murine T cells. AN - 79891983; 2197329 AB - The granulocyte-macrophage CSF (GM-CSF) gene is known to be controlled at a variety of levels in different cell types. We showed previously that GM-CSF production by lectin or phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate (TPA]-treated T cells was unaffected by cyclosporin A whereas IL-2 and IL-3 expression were. Cyclosporin A is thought to inhibit transcription that suggests that IL-2 and IL-3 are regulated primarily at the transcriptional level while GM-CSF is not. The lack of coordinate gene expression is of particular interest because all three mRNA share the presence of adenosine uridine-rich sequences in the 3' untranslated region and these sequences are believed to act by modulating mRNA stability. We measured the level of GM-CSF mRNA in untreated cells and found it to be extremely low. GM-CSF mRNA levels increased approximately 60-fold within 6 h of TPA-treatment. Nuclear run-on transcription analysis of the same cells showed readily detectable GM-CSF transcription in unstimulated cells that increased less than twofold after TPA treatment. However, IL-2 transcription was insignificant before TPA addition. Actinomycin D chase experiments showed that GM-CSF transcripts in untreated cells have a very short half-life (approximately 45 min) although transcripts in TPA-treated cells have a half-life exceeding 3 h. These findings indicate that GM-CSF production in EL-4 cells treated with TPA is regulated predominantly by modulation of cytoplasmic mRNA half-life. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Bickel, M AU - Cohen, R B AU - Pluznik, D H AD - Division of Cytokine Biology Center for Biologics, Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/08/01/ PY - 1990 DA - 1990 Aug 01 SP - 840 EP - 845 VL - 145 IS - 3 SN - 0022-1767, 0022-1767 KW - Colony-Stimulating Factors KW - 0 KW - Cyclosporins KW - Growth Substances KW - Interleukin-2 KW - RNA, Messenger KW - Dichlororibofuranosylbenzimidazole KW - 53-85-0 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Cycloheximide KW - 98600C0908 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Transcription, Genetic -- drug effects KW - Tumor Cells, Cultured KW - Half-Life KW - Cycloheximide -- pharmacology KW - Dichlororibofuranosylbenzimidazole -- pharmacology KW - RNA, Messenger -- analysis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Interleukin-2 -- biosynthesis KW - Mice KW - Cyclosporins -- pharmacology KW - T-Lymphocytes -- metabolism KW - Growth Substances -- biosynthesis KW - Colony-Stimulating Factors -- biosynthesis KW - Gene Expression Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79891983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Post-transcriptional+regulation+of+granulocyte-macrophage+colony-stimulating+factor+synthesis+in+murine+T+cells.&rft.au=Bickel%2C+M%3BCohen%2C+R+B%3BPluznik%2C+D+H&rft.aulast=Bickel&rft.aufirst=M&rft.date=1990-08-01&rft.volume=145&rft.issue=3&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-28 N1 - Date created - 1990-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - AIDS service demonstration programs: 3 year report, 1987-1989 AN - 59573037; 1991-0713064 AB - Extent of program development, operations, and outcomes in meeting the health care needs of people with acquired immune deficiency syndrome; US. JF - Washington, DC 20447, August 1990. 68 pp. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 68 PB - Washington, DC 20447 KW - United States -- Health policy KW - Sociology, Medical -- United States KW - Acquired immune deficiency syndrome -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59573037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=AIDS+service+demonstration+programs%3A+3+year+report%2C+1987-1989&rft.title=AIDS+service+demonstration+programs%3A+3+year+report%2C+1987-1989&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20447 pa N1 - Document feature - chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Incidence of Vibrio parahaemolyticus in U.S. Coastal Waters and Oysters AN - 19104484; 9100825 AB - Vibrio parahaemolyticus is an enteric pathogen transmitted to humans primarily through consumption of raw or mishandled seafood. Oyster and seawater samples were collected seasonally from May 1984 through April 1985 from shellfish-growing areas in Washington, California, Texas, Louisiana, Alabama, Florida, South Carolina, Virginia, and Rhode Island which had been designated as approved or prohibited by the National Shellfish Sanitation Program. Fecal coliform counts, aerobic plate counts, and Vibrio parahaemolyticus densities were determined for the samples. Mean V. parahaemolyticus density was more than 100 times greater in oysters than in water, whereas density of fecal coliforms was approximately 10 times higher in oysters. Seasonal and geographical distributions of V. parahaemolyticus were related to water temperature, with highest densities in samples collected in the spring and the summer along the Gulf coast. The synthetic DNA probe for thermostable direct hemolysin hybridized with 2 of 50 isolates, one of which was positive by the Kanagawa test. (Author 's abstract) JF - Applied and Environmental Microbiology AEMIDF, Vol. 56, No. 8, p 2299-2302, August 1990. 4 tab, 27 ref. AU - McPhearson, R M AU - Wentz, B AU - Peeler, J T AU - Hopkins, L H AU - DePaola, A AD - Food and Drug Administration Y1 - 1990/08// PY - 1990 DA - Aug 1990 KW - Water Resources Abstracts KW - Bioaccumulation Enteric bacteria Oysters Path of pollutants KW - Shellfish Vibrio Alabama California Fecal coliforms Florida KW - Louisiana Rhode Island Seasonal variation Seawater South KW - Carolina Texas Virginia Washington Water temperature KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19104484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Incidence+of+Vibrio+parahaemolyticus+in+U.S.+Coastal+Waters+and+Oysters&rft.au=McPhearson%2C+R+M%3BWentz%2C+B%3BPeeler%2C+J+T%3BHopkins%2C+L+H%3BDePaola%2C+A&rft.aulast=McPhearson&rft.aufirst=R&rft.date=1990-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. AN - 79841728; 2355431 AB - The Food and Drug Administration documents the receipt of 12 case reports of severe myopathy or rhabdomyolysis associated with concomitant use of lovastatin and gemfibrozil, including 10 voluntary postmarketing, and 2 required, reports. All patients had serum creatine kinase levels of more than 10,000 U/L, 4 tested showed myoglobinuria, and 5 had acute renal failure. The patients' symptoms resolved when both drugs were discontinued. For the first year of marketing of lovastatin, spontaneous reports of myopathy with documentation of creatine kinase level were reviewed for the use of lovastatin, gemfibrozil, and combination therapy. The median creatine kinase level in reports involving concomitant lovastatin and gemfibrozil use was 15,250 U/L, 20 times that in reports with gemfibrozil use alone and 30 times that in reports with lovastatin use alone. Because of the potential for severe myopathy and life-threatening rhabdomyolysis, and given alternative drug combinations for treating hyperlipoproteinemia, the use of lovastatin in combination with gemfibrozil is to be discouraged. JF - JAMA AU - Pierce, L R AU - Wysowski, D K AU - Gross, T P AD - Division of Metabolism and Endocrine Drug Products, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/07/04/ PY - 1990 DA - 1990 Jul 04 SP - 71 EP - 75 VL - 264 IS - 1 SN - 0098-7484, 0098-7484 KW - Lovastatin KW - 9LHU78OQFD KW - Creatine Kinase KW - EC 2.7.3.2 KW - Gemfibrozil KW - Q8X02027X3 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Creatine Kinase -- blood KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Hypercholesterolemia -- drug therapy KW - Female KW - Lovastatin -- adverse effects KW - Muscular Diseases -- chemically induced KW - Lovastatin -- administration & dosage KW - Gemfibrozil -- administration & dosage KW - Rhabdomyolysis -- chemically induced KW - Rhabdomyolysis -- blood KW - Muscular Diseases -- blood KW - Gemfibrozil -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79841728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Myopathy+and+rhabdomyolysis+associated+with+lovastatin-gemfibrozil+combination+therapy.&rft.au=Pierce%2C+L+R%3BWysowski%2C+D+K%3BGross%2C+T+P&rft.aulast=Pierce&rft.aufirst=L&rft.date=1990-07-04&rft.volume=264&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-20 N1 - Date created - 1990-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1990 Dec 19;264(23):2991-2 [2243420] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of interferon-alpha in patients with AIDS-associated Kaposi's sarcoma are related to blood interferon levels and dose. AN - 80396764; 2104226 AB - Definition of improved therapeutic regimens of interferon-alpha (IFN-alpha) for the treatment of Kaposi's sarcoma (KS) would be useful since currently recommended doses are sometimes associated with unacceptable toxicity. IFN concentrations were measured in serum samples from men with AIDS-associated KS who were enrolled in a trial of IFN-alpha alone (16 patients) or a trial of IFN-alpha combined with zidovudine (25 patients). Analyses were done to examine the relationship between the dose of IFN-alpha, blood level of IFN, and the patient's clinical response to treatment. There was no correlation between dose of zidovudine given and response. As expected, there was a high correlation between dose of IFN-alpha and blood level in both studies (p less than 0.001). Furthermore, we found relationships between clinical response and both dose of IFN-alpha and blood level achieved. In the two studies combined, among men with greater than 200 CD4+ cells/mm3 of blood at baseline on average daily doses of greater than or equal to 10 million international units (MIU) of IFN-alpha, 13/19 (68%) responded compared to 6/17 (35%) on less than MIU (p = 0.05). Similarly, of men with IFN blood levels greater than or equal to 100 IU/mL 12/16 (75%) responded compared to 7/20 (35%) of those with blood levels less than 100 IU/mL (p = 0.02). The dose and blood levels of IFN achieved and maintained may be important factors in determining responses of KS. Additional clinical trials of IFN-alpha treatment of KS at doses about 10 MIU/day appear warranted. JF - Cytokine AU - Sawyer, L A AU - Metcalf, J A AU - Zoon, K C AU - Boone, E J AU - Kovacs, J A AU - Lane, H C AU - Quinnan, G V AD - Laboratory of Retrovirus Research, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 247 EP - 252 VL - 2 IS - 4 SN - 1043-4666, 1043-4666 KW - Interferon-alpha KW - 0 KW - Recombinant Proteins KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - AIDS/HIV KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Zidovudine -- administration & dosage KW - Middle Aged KW - Male KW - HIV Seropositivity -- drug therapy KW - Sarcoma, Kaposi -- drug therapy KW - Interferon-alpha -- administration & dosage KW - Interferon-alpha -- pharmacokinetics KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Interferon-alpha -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80396764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Effects+of+interferon-alpha+in+patients+with+AIDS-associated+Kaposi%27s+sarcoma+are+related+to+blood+interferon+levels+and+dose.&rft.au=Sawyer%2C+L+A%3BMetcalf%2C+J+A%3BZoon%2C+K+C%3BBoone%2C+E+J%3BKovacs%2C+J+A%3BLane%2C+H+C%3BQuinnan%2C+G+V&rft.aulast=Sawyer&rft.aufirst=L&rft.date=1990-07-01&rft.volume=2&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-22 N1 - Date created - 1991-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The metabolic N-oxidation of carcinogenic arylamines in relation to nitrogen charge density and oxidation potential. AN - 80204829; 2269230 AB - The N-oxidation of carcinogenic arylamines to form N-hydroxy arylamines has long been regarded as a necessary metabolic step for conversion to proximate carcinogenic derivatives. In contrast, arylamine ring-oxidation has been generally considered to be an important detoxification mechanism. Both enzymatic reactions are carried out in the liver and usually involve the cytochrome P-450 monooxygenases. Studies on the metabolic oxidation of certain arylamines have indicated that the relative charge density on nitrogen versus ring-carbon atoms for a nitrenium/carbenium ion-enzyme intermediate correlates with the relative proportion of N-versus ring-hydroxylated products that are formed. A further examination of this approach now shows that positive charge density on the nitrogen, as estimated by Hückel molecular orbital calculations, is consistent with the formation of N-hydroxy arylamines from aniline, 4-aminoazobenzene, 2-naphthylamine, 4-aminobiphenyl, 2-aminofluorene, and 6-aminochrysene, but not from 1-naphthylamine, 1-aminopyrene, 6-aminobenzo[a]pyrene, or 7-aminobenz[a]anthracene. Since greater positive charge on the arylamine nitrogen implies a greater charge localization during the transition state of the enzyme-substrate complex, we envisioned that higher oxidation potentials for arylamines, which might be expected to correlate inversely with the ease of total oxidation, would instead be predictive of the relative extent of N-oxidation.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Environmental health perspectives AU - Kadlubar, F F AU - Fu, P P AU - Jung, H AU - Shaikh, A U AU - Beland, F A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 233 EP - 236 VL - 87 SN - 0091-6765, 0091-6765 KW - Amines KW - 0 KW - Carcinogens KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxygenases KW - EC 1.13.- KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Oxidation-Reduction KW - Inactivation, Metabolic KW - Oxygenases -- metabolism KW - Chemistry, Physical KW - Chemical Phenomena KW - Cytochrome P-450 Enzyme System -- metabolism KW - Structure-Activity Relationship KW - Carcinogens -- metabolism KW - Biotransformation KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- chemistry KW - Amines -- metabolism KW - Amines -- chemistry KW - Amines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80204829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+metabolic+N-oxidation+of+carcinogenic+arylamines+in+relation+to+nitrogen+charge+density+and+oxidation+potential.&rft.au=Kadlubar%2C+F+F%3BFu%2C+P+P%3BJung%2C+H%3BShaikh%2C+A+U%3BBeland%2C+F+A&rft.aulast=Kadlubar&rft.aufirst=F&rft.date=1990-07-01&rft.volume=87&rft.issue=&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-21 N1 - Date created - 1991-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1985 Aug;45(8):3578-85 [4016738] Carcinogenesis. 1985 Aug;6(8):1235-8 [3893788] Environ Health Perspect. 1985 Oct;62:19-30 [4085422] Adv Cancer Res. 1974;20:165-274 [4617500] Xenobiotica. 1986 Oct-Nov;16(10-11):933-55 [3541401] Carcinogenesis. 1987 Nov;8(11):1703-9 [3664962] Cancer Res. 1989 Jan 1;49(1):25-31 [2908851] Crit Rev Toxicol. 1986;17(1):23-60 [2427276] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Guidelines for medical screening in the workplace. AN - 80056812; 2218794 AB - This chapter deals with general principles of conducting medical examinations to detect adverse health effects of workplace exposures and thereby prevent occupational disease or slow its progression. Much of the discussion is most relevant to screening for effects of chemical hazards, but many of the principles presented apply to physical and biological hazards as well. Procedural and administrative aspects of workplace medical examinations that are not "exposure specific" and are applicable to all medical programs are reviewed. JF - Occupational medicine (Philadelphia, Pa.) AU - Matte, T D AU - Fine, L AU - Meinhardt, T J AU - Baker, E L AD - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia. PY - 1990 SP - 439 EP - 456 VL - 5 IS - 3 SN - 0885-114X, 0885-114X KW - Index Medicus KW - Physical Examination -- methods KW - Humans KW - Occupational Diseases -- prevention & control KW - Health Planning Guidelines KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80056812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Guidelines+for+medical+screening+in+the+workplace.&rft.au=Matte%2C+T+D%3BFine%2C+L%3BMeinhardt%2C+T+J%3BBaker%2C+E+L&rft.aulast=Matte&rft.aufirst=T&rft.date=1990-07-01&rft.volume=5&rft.issue=3&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Current regulatory issues regarding sterile products. AN - 80035389; 2213432 JF - Journal of parenteral science and technology : a publication of the Parenteral Drug Association AU - Avallone, H AD - Department of Health and Human Services, Food and Drug Administration, West Orange, New Jersey. PY - 1990 SP - 228 EP - 230 VL - 44 IS - 4 SN - 0279-7976, 0279-7976 KW - Index Medicus KW - United States KW - Infusions, Parenteral KW - Environmental Monitoring -- methods KW - Sterilization -- methods KW - Drug Industry -- methods KW - Drug Industry -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80035389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+parenteral+science+and+technology+%3A+a+publication+of+the+Parenteral+Drug+Association&rft.atitle=Current+regulatory+issues+regarding+sterile+products.&rft.au=Avallone%2C+H&rft.aulast=Avallone&rft.aufirst=H&rft.date=1990-07-01&rft.volume=44&rft.issue=4&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Journal+of+parenteral+science+and+technology+%3A+a+publication+of+the+Parenteral+Drug+Association&rft.issn=02797976&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-02 N1 - Date created - 1990-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Improved gas chromatographic method for determination of daminozide by alkaline hydrolysis and 2-nitrobenzaldehyde derivatization and survey results of daminozide in agricultural products. AN - 80029820; 2211471 AB - An improved method was developed for the quantitative determination of daminozide. This new method combines the alkaline hydrolysis and distillation steps of the PAM II method for daminozide with the derivatization, cleanup, and gas chromatographic determination steps of the Wright method for unsymmetrical dimethyl hydrazine (UDMH). The minimum detectable level is 0.05 ppm. Recoveries range from 85 to 110% when daminozide is added at 0.1 to 1.0 ppm, and are generally 40% at the 0.05 ppm level. A variety of domestic and imported products were analyzed by this improved method and daminozide was detected in 33 of the 98 samples analyzed. Levels detected ranged from a trace amount to 0.80 ppm. The identity of UDMH hydrazone was confirmed by mass spectrometry in many samples, thus confirming the presence of daminozide. Two samples containing daminozide were analyzed independently by a second laboratory and the findings were closely duplicated. JF - Journal - Association of Official Analytical Chemists AU - Steinbrecher, K AU - Saxton, W L AU - Oehler, G A AD - U.S. Food and Drug Administration, Bothell, WA 98041-3012. PY - 1990 SP - 512 EP - 515 VL - 73 IS - 4 SN - 0004-5756, 0004-5756 KW - Benzaldehydes KW - 0 KW - Herbicides KW - Indicators and Reagents KW - Succinates KW - 2-nitrobenzaldehyde KW - 552-89-6 KW - daminozide KW - F6KF33M5UB KW - Index Medicus KW - Chemistry KW - Food Analysis KW - Fruit -- analysis KW - Chemical Phenomena KW - Gas Chromatography-Mass Spectrometry KW - Hydrolysis KW - Herbicides -- analysis KW - Succinates -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80029820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Improved+gas+chromatographic+method+for+determination+of+daminozide+by+alkaline+hydrolysis+and+2-nitrobenzaldehyde+derivatization+and+survey+results+of+daminozide+in+agricultural+products.&rft.au=Steinbrecher%2C+K%3BSaxton%2C+W+L%3BOehler%2C+G+A&rft.aulast=Steinbrecher&rft.aufirst=K&rft.date=1990-07-01&rft.volume=73&rft.issue=4&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-02 N1 - Date created - 1990-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Respirable dust exposures in U.S. surface coal mines (1982-1986). AN - 80001160; 2169228 AB - Exposure of miners to respirable coal mine dust and to respirable quartz silica at surface coal mines in the United States during 1982-1986 were evaluated by job category using data collected by coal mine operators and Mine Safety and Health Administration (MSHA) inspectors. Average coal mine dust concentrations were usually well below the MSHA Permissible Exposure Limit (PEL) for all job categories, but at least 10% of the samples obtained from some coal preparation plant job areas and most drilling job areas had concentrations that exceeded the 2.0 mg/m3 limit. In contrast, a very high proportion of samples from surface mine driller areas exceeded the quartz PEL. Of all samples collected for highwall drill operators and helpers, 78% and 77%, respectively, were greater than the 0.1 mg/m3 quartz exposure limit (average concentrations were .32 and .36 mg/m3, respectively). Although MSHA compliance data may not be entirely adequate for assessing chronic exposure to quartz, these data and the results of other NIOSH studies nonetheless indicate excessive exposure to silica in a group of surface coal miners. JF - Archives of environmental health AU - Piacitelli, G M AU - Amandus, H E AU - Dieffenbach, A AD - Centers for Disease Control, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia. PY - 1990 SP - 202 EP - 209 VL - 45 IS - 4 SN - 0003-9896, 0003-9896 KW - Air Pollutants, Occupational KW - 0 KW - Coal KW - Dust KW - Quartz KW - 14808-60-7 KW - Silicon Dioxide KW - 7631-86-9 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Environmental Monitoring KW - Silicon Dioxide -- analysis KW - Maximum Allowable Concentration KW - Humans KW - Quartz -- adverse effects KW - Quartz -- analysis KW - Silicon Dioxide -- adverse effects KW - Coal -- adverse effects KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Job Description KW - Coal Mining KW - Dust -- adverse effects KW - Personnel Management KW - Coal -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80001160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Respirable+dust+exposures+in+U.S.+surface+coal+mines+%281982-1986%29.&rft.au=Piacitelli%2C+G+M%3BAmandus%2C+H+E%3BDieffenbach%2C+A&rft.aulast=Piacitelli&rft.aufirst=G&rft.date=1990-07-01&rft.volume=45&rft.issue=4&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-18 N1 - Date created - 1990-10-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Effect of pretreatment with hepatic mixed-function oxidase inducers on the genotoxicity of four rat carcinogens in the hepatocyte/DNA repair assay. AN - 79991761; 2169015 AB - Four genotoxic rat carcinogens, previously reported as negative in the standard hepatocyte/DNA repair assay, were studied in hepatocyte cultures derived from the livers of rats pretreated with the hepatic mixed-function oxidase (MFO) inducers, Aroclor (ARO) and 3-methylcholanthrene (3-MC). Cytembena and dimethyl hydrogen phosphite induced positive dose-dependent DNA repair responses in ARO- and 3-MC-pretreated cultures, while 2,4-, 2,6-toluene diisocyanate, and ziram were negative for unscheduled DNA synthesis in cultures from both pretreatments. The results from this study indicate that pretreatment with hepatic MFO inducers lowers the false-negative detection rate of various genotoxic rat carcinogens and other organ-specific genotoxins and significantly increases the sensitivity of the in vitro rat hepatocyte/DNA repair assay. JF - Mutagenesis AU - Shaddock, J G AU - Robinson, B Y AU - Casciano, D A AD - Food and Drug Administration, Division of Genetic Toxicology, Jefferson, AR 72079. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 387 EP - 391 VL - 5 IS - 4 SN - 0267-8357, 0267-8357 KW - Acrylates KW - 0 KW - Aroclors KW - Carcinogens KW - Organophosphonates KW - Organophosphorus Compounds KW - Phosphites KW - Toluene 2,4-Diisocyanate KW - 17X7AFZ1GH KW - Methylcholanthrene KW - 56-49-5 KW - Ziram KW - 73D8UA974J KW - 2,6-diisocyanatotoluene KW - 78243HXH5O KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - bromebric acid KW - FGE8818GWA KW - dimethyl hydrogen phosphite KW - ST4TBO000H KW - Index Medicus KW - Animals KW - Liver -- cytology KW - Dose-Response Relationship, Drug KW - Toluene 2,4-Diisocyanate -- toxicity KW - Ziram -- toxicity KW - Acrylates -- toxicity KW - Rats KW - Mutagenicity Tests KW - Rats, Inbred F344 KW - Cells, Cultured KW - Liver -- drug effects KW - Isomerism KW - Organophosphorus Compounds -- toxicity KW - Male KW - Aroclors -- pharmacology KW - Methylcholanthrene -- pharmacology KW - Polychlorinated Biphenyls -- pharmacology KW - Carcinogens -- toxicity KW - Mutation KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79991761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Effect+of+pretreatment+with+hepatic+mixed-function+oxidase+inducers+on+the+genotoxicity+of+four+rat+carcinogens+in+the+hepatocyte%2FDNA+repair+assay.&rft.au=Shaddock%2C+J+G%3BRobinson%2C+B+Y%3BCasciano%2C+D+A&rft.aulast=Shaddock&rft.aufirst=J&rft.date=1990-07-01&rft.volume=5&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-12 N1 - Date created - 1990-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A review of sulphites in foods: analytical methodology and reported findings. AN - 79973229; 2203650 AB - Sulphites in various forms have been added to foods for centuries. Their use became an issue of concern when certain sensitive individuals exhibited adverse reactions to sulphite residues in foods. Analytical methods were developed to monitor these compounds at the regulatory limit of 10 ppm. In this report, analytical methods for determining sulphites in foods are reviewed, along with a critique of their chemistry and procedural schemes. An assessment of the key features of each method category is presented together with some comparative data. The classification scheme used is based upon the fact that determination of the sulphite content of a food is influenced more by the treatment and cleanup of the test solution than by the final determinative step. Based on a 60-year database, the Monier-Williams procedure still remains the method of choice. JF - Food additives and contaminants AU - Fazio, T AU - Warner, C R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. PY - 1990 SP - 433 EP - 454 VL - 7 IS - 4 SN - 0265-203X, 0265-203X KW - Enzymes KW - 0 KW - Food Preservatives KW - Sulfites KW - Sulfur Dioxide KW - 0UZA3422Q4 KW - Index Medicus KW - Chemistry KW - Sulfur Dioxide -- isolation & purification KW - Chromatography KW - Humans KW - Chemical Phenomena KW - Food Preservatives -- analysis KW - Food Preservatives -- adverse effects KW - Food Analysis -- methods KW - Sulfites -- analysis KW - Sulfites -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79973229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=A+review+of+sulphites+in+foods%3A+analytical+methodology+and+reported+findings.&rft.au=Fazio%2C+T%3BWarner%2C+C+R&rft.aulast=Fazio&rft.aufirst=T&rft.date=1990-07-01&rft.volume=7&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-11 N1 - Date created - 1990-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Medical examiner/coroner records: uses and limitations in occupational injury epidemiologic research. AN - 79966170; 2391482 AB - Epidemiologic research often relies on existing data, collected for nonepidemiologic reasons, to support studies. Data are obtained from hospital records, police reports, labor reports, death certificates, or other sources. Medical examiner/coroner records are, however, not often used in epidemiologic studies. The National Institute for Occupational Safety and Health's Division of Safety Research has begun using these records in its research program on work-related trauma. Because medical examiners and coroners have the legal authority and responsibility to investigate all externally caused deaths, these records can be used in surveillance of these deaths. Another use of these records is to validate cases identified by other case ascertainment methods, such as death certificates. Using medical examiner/coroner records also allows rapid identification of work-related deaths without waiting several years for mortality data from state offices of vital statistics. Finally, the records are an invaluable data source since they contain detailed information on the nature of the injury, external cause of death, and results of toxicologic testing, which is often not available from other sources. This paper illustrates some of the ways that medical examiner/coroner records are a valuable source of information for epidemiologic studies and makes recommendations to improve their usefulness. JF - Journal of forensic sciences AU - Conroy, C AU - Russell, J C AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 932 EP - 937 VL - 35 IS - 4 SN - 0022-1198, 0022-1198 KW - Index Medicus KW - United States KW - Humans KW - Wounds and Injuries -- epidemiology KW - Medical Records KW - Coroners and Medical Examiners KW - Accidents, Occupational -- statistics & numerical data KW - United States Occupational Safety and Health Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79966170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+forensic+sciences&rft.atitle=Medical+examiner%2Fcoroner+records%3A+uses+and+limitations+in+occupational+injury+epidemiologic+research.&rft.au=Conroy%2C+C%3BRussell%2C+J+C&rft.aulast=Conroy&rft.aufirst=C&rft.date=1990-07-01&rft.volume=35&rft.issue=4&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Journal+of+forensic+sciences&rft.issn=00221198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-02 N1 - Date created - 1990-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Developmental effects and mineral interactions in rats fed textured vegetable protein. AN - 79965923; 2392780 AB - The teratogenic effects of feeding a diet based on textured vegetable protein to Long-Evans rats were studied along with maternal and fetal mineral interactions and their relationship to diet composition. Pregnant rats were fed purified diets containing 18% protein as casein (CAS), textured vegetable protein (TVP, from defatted soy flour) with 18 mg Zn/kg, or TVP diet with 100 mg Zn/kg. A fourth group was fed diet NIH-31. The animals received their diets throughout pregnancy and were sacrificed on day 20 of gestation. Fetuses were examined for developmental effects, and mineral levels were determined in maternal and fetal tissues by inductively coupled argon plasma-atomic emission spectrometry. Females fed the casein diet or diet NIH-31 had normal weight gains throughout pregnancy and their progeny exhibited normal development. The animals on the TVP-containing diet with 18 mg Zn/kg had decreased food consumption and body weights, and their fetuses exhibited developmental anomalies as well as reductions in size and weight. These developmental alterations may be the result of decreased zinc levels in the fetal tissues, caused by reduced bioavailability of the trace element in the maternal diet. Significant increases in tissue iron accompanied the low zinc levels. No developmental effects were found in animals receiving the high Zn-TVP diet, and mineral data from these animals were not significantly different from the casein group. JF - Teratology AU - Welsh, J J AU - Rader, J I AU - Collins, T F AU - Black, T N AU - Rorie, J I AU - Kopral, C A AD - Division of Toxicological Review and Evaluations, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 67 EP - 78 VL - 42 IS - 1 SN - 0040-3709, 0040-3709 KW - Caseins KW - 0 KW - Plant Proteins KW - Copper KW - 789U1901C5 KW - Iron KW - E1UOL152H7 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Caseins -- pharmacology KW - Body Weight KW - Animals KW - Copper -- metabolism KW - Diet KW - Male KW - Iron -- metabolism KW - Female KW - Pregnancy KW - Viscera -- metabolism KW - Embryonic and Fetal Development KW - Plant Proteins -- pharmacology KW - Viscera -- drug effects KW - Zinc -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79965923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Developmental+effects+and+mineral+interactions+in+rats+fed+textured+vegetable+protein.&rft.au=Welsh%2C+J+J%3BRader%2C+J+I%3BCollins%2C+T+F%3BBlack%2C+T+N%3BRorie%2C+J+I%3BKopral%2C+C+A&rft.aulast=Welsh&rft.aufirst=J&rft.date=1990-07-01&rft.volume=42&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-03 N1 - Date created - 1990-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevalence of hypercholesterolemia in a maritime population. AN - 79965261; 2391574 AB - The problem of hypercholesterolemia is of growing concern and public awareness. The cholesterol determinations of 567 maritime personnel, dependent upon a shipboard diet for a major portion of the year, were reviewed. Total cholesterol levels were borderline in 32.7% and high in 28.2% of the population, using definitions of the National Cholesterol Education Program. There was an age-related increase in average total cholesterol levels. The levels of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in this population are also reported where available. The opportunities for intervention in this population are unique, as are the potential impediments to intervention. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Brown, W D AD - Division of Federal Employee Occupational Health, US Public Health Service/Region X, Seattle, WA 98121. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 612 EP - 615 VL - 32 IS - 7 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - Age Factors KW - Washington -- epidemiology KW - Humans KW - Adult KW - Middle Aged KW - Naval Medicine KW - Male KW - Female KW - Prevalence KW - Occupational Diseases -- epidemiology KW - Hypercholesterolemia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79965261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Prevalence+of+hypercholesterolemia+in+a+maritime+population.&rft.au=Brown%2C+W+D&rft.aulast=Brown&rft.aufirst=W&rft.date=1990-07-01&rft.volume=32&rft.issue=7&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-04 N1 - Date created - 1990-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Listeria species in a California coast estuarine environment. AN - 79959510; 2117874 AB - Listeria species and L. monocytogenes were found in 81 and 62%, respectively, of fresh or low-salinity waters (37 samples) in tributaries draining into Humboldt-Arcata Bay, Calif., during a winter (January-February) sampling period. The incidence of Listeria species and L. monocytogenes in sediment (46 samples) from the same sites where water was sampled was 30.4 and 17.4%, respectively. One of three bay water samples contained Listeria species (including L. monocytogenes), while of 35 samples of oysters examined, only 1 was found positive for Listeria species (L. innocua). A given species or L. monocytogenes serogroup appeared to predominate in fresh water when domesticated animals (cows, horses) were nearby, whereas greater variety with no species predominance was observed in areas with no direct animal influence. JF - Applied and environmental microbiology AU - Colburn, K G AU - Kaysner, C A AU - Abeyta, C AU - Wekell, M M AD - Seafood Products Research Center, U.S. Food and Drug Administration, Bothell, Washington 98041-3012. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 2007 EP - 2011 VL - 56 IS - 7 SN - 0099-2240, 0099-2240 KW - Index Medicus KW - California KW - Animals KW - Listeria monocytogenes -- isolation & purification KW - Food Microbiology KW - Fresh Water KW - Seawater KW - Food Contamination KW - Ostreidae -- microbiology KW - Species Specificity KW - Water Microbiology KW - Listeria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79959510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Listeria+species+in+a+California+coast+estuarine+environment.&rft.au=Colburn%2C+K+G%3BKaysner%2C+C+A%3BAbeyta%2C+C%3BWekell%2C+M+M&rft.aulast=Colburn&rft.aufirst=K&rft.date=1990-07-01&rft.volume=56&rft.issue=7&rft.spage=2007&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-27 N1 - Date created - 1990-09-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bacteriol Rev. 1966 Jun;30(2):309-82 [4956900] J Bacteriol. 1960 Sep;80:316-20 [13784295] J Clin Microbiol. 1980 Apr;11(4):385-8 [6989857] J Appl Bacteriol. 1981 Feb;50(1):1-9 [6262293] N Engl J Med. 1983 Jan 27;308(4):203-6 [6401354] Pediatr Infect Dis. 1984 Jan-Feb;3(1):30-4 [6701102] N Engl J Med. 1985 Feb 14;312(7):404-7 [3918263] J Appl Bacteriol. 1985 Dec;59(6):537-43 [3938452] Appl Environ Microbiol. 1986 Jul;52(1):59-63 [3089158] Appl Environ Microbiol. 1987 Jun;53(6):1344-8 [3606111] Microbiol Rev. 1987 Sep;51(3):365-79 [3312987] Appl Environ Microbiol. 1987 Sep;53(9):2256-9 [2823710] N Engl J Med. 1988 Sep 29;319(13):823-8 [3137471] Microbiol Sci. 1988 Dec;5(12):355-8 [3079177] J Hyg (Lond). 1952 Jun;50(2):137-56 [14938529] Appl Microbiol. 1975 Jul;30(1):29-32 [807164] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice. AN - 79939538; 2385841 AB - The hepatotoxicity of acetaminophen is believed to be mediated by the metabolic activation of acetaminophen to N-acetyl-p-benzoquinone imine which covalently binds to cysteinyl residues on proteins as 3-(cystein-S-yl)acetaminophen adducts. The formation of these adducts in hepatic protein correlates with the hepatotoxicity. In this study, the formation of 3-(cystein-S-yl)acetaminophen adducts in specific cellular proteins was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and detected using affinity-purified antisera specific for 3-(cystein-S-yl)acetaminophen adducts on immunoblots. These techniques were used to investigate the liver 10,000g supernatant and serum from B6C3F1 mice that received hepatotoxic doses of acetaminophen. More than 15 proteins containing 3-(cystein-S-yl)acetaminophen adducts were detected in the liver 10,000g supernatant. The most prominent protein containing 3-(cystein-S-yl)acetaminophen adducts in the hepatic 10,000g supernatant had a relative molecular mass of 55 kDa. Serum proteins containing 3-(cystein-S-yl)acetaminophen adducts had molecular masses similar to those found in the liver 10,000g supernatant (55, 87, and approximately 102 kDa). These data, combined with our previous findings describing the temporal relationship between the appearance of 3-(cystein-S-yl)acetaminophen adducts in protein in the serum and the decrease in the levels of 3-(cystein-S-yl)acetaminophen adducts in protein in the liver, suggested that liver adducts were released into the serum following lysis of hepatocytes. The temporal relationship between the formation of specific adducts and hepatotoxicity in mice following a hepatotoxic dose of acetaminophen was examined using immunoblots of mitochondria, microsomes, cytosol, and plasma membranes. Hepatotoxicity indicated by serum alanine aminotransferase levels was increased at 2 and 4 hr after dosing. The cytosolic fraction contained numerous proteins with 3-(cystein-S-yl)acetaminophen adducts, the most intensely stained of which was a 55-kDa protein. 3-(Cystein-S-yl)acetaminophen adducts were detected in the 55-kDa liver protein 30 min after dosing and prior to the development of significant toxicity. Examination of gels suggested that maximal levels of immunochemically detectable adducts in the 55-kDa protein occurred at 1-2 hr, with a decrease in intensity 4 hr after dosing. The presence of 3-(cystein-S-yl)acetaminophen adducts in proteins prior to hepatotoxicity suggests a threshold for adduct formation in the development of toxicity. Protein in microsomes which contained 3-(cystein-S-yl)acetaminophen adducts ranged in molecular weight from 38 to approximately 106 kDa. The major proteins containing 3-(cystein-S-yl)acetaminophen adducts in the mitochondria had molecular masses of 39, 50, 68, and 79 kDa.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Toxicology and applied pharmacology AU - Pumford, N R AU - Hinson, J A AU - Benson, R W AU - Roberts, D W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 521 EP - 532 VL - 104 IS - 3 SN - 0041-008X, 0041-008X KW - Proteins KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Animals KW - Cytosol -- analysis KW - Electrophoresis, Polyacrylamide Gel KW - Alanine Transaminase -- analysis KW - Mice KW - Cell Membrane -- analysis KW - Mice, Inbred Strains KW - Blotting, Western KW - Microsomes -- analysis KW - Binding, Competitive KW - Proteins -- analysis KW - Mitochondria -- analysis KW - Male KW - Acetaminophen -- metabolism KW - Liver -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79939538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Immunoblot+analysis+of+protein+containing+3-%28cystein-S-yl%29acetaminophen+adducts+in+serum+and+subcellular+liver+fractions+from+acetaminophen-treated+mice.&rft.au=Pumford%2C+N+R%3BHinson%2C+J+A%3BBenson%2C+R+W%3BRoberts%2C+D+W&rft.aulast=Pumford&rft.aufirst=N&rft.date=1990-07-01&rft.volume=104&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-14 N1 - Date created - 1990-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Household survey of child-safe packaging for medications. AN - 79925476; 2116650 AB - In an investigation of the prevalence of safety packaging of medications, 131 randomly selected Minneapolis and St. Paul households with children were surveyed in 1985. Of the 1,953 oral medications in these households (mean was 14.9 per home), 43.3 percent did not have safety packaging. Over-the-counter medications were less likely to have safety packaging than prescription medications (over-the-counter 53.1 percent, prescription 25 percent). This high prevalence of medications without safety packaging in households with children could increase the risk of childhood poisoning. Strategies to reduce this potential risk are discussed. JF - Public health reports (Washington, D.C. : 1974) AU - Gulaid, J A AU - Hadsall, R S AU - Sacks, J J AU - Wertheimer, A I AD - Division of Injury Epidemiology and Control, Centers for Disease Control, Public Health Service, Atlanta, GA 30333. PY - 1990 SP - 430 EP - 432 VL - 105 IS - 4 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Minnesota KW - Humans KW - Data Collection KW - Child, Preschool KW - Drug Packaging KW - Poisoning -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79925476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Household+survey+of+child-safe+packaging+for+medications.&rft.au=Gulaid%2C+J+A%3BHadsall%2C+R+S%3BSacks%2C+J+J%3BWertheimer%2C+A+I&rft.aulast=Gulaid&rft.aufirst=J&rft.date=1990-07-01&rft.volume=105&rft.issue=4&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-13 N1 - Date created - 1990-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pediatrics. 1982 Mar;69(3):363-70 [7063294] Am J Emerg Med. 1984 Sep;2(5):420-43 [6518053] Am J Public Health. 1989 Jul;79(7):853-6 [2660604] Am J Prev Med. 1987 May-Jun;3(3):164-70 [3452354] Am J Public Health. 1986 Nov;76(11):1335-6 [3766832] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Blood lead levels of 4-11-year-old Mexican American, Puerto Rican, and Cuban children. AN - 79923374; 2116641 AB - Data from the Hispanic Health and Nutrition Examination Survey were used to estimate arithmetic mean blood lead and percent with elevated blood lead [25 micrograms per deciliter (micrograms per dl) or greater] for 4-11-year-old Mexican American, Puerto Rican, and Cuban children. The sample size was 1,390 for Mexican American children, 397 for Puerto Rican children, and 114 for Cuban children. Puerto Rican children had the highest mean blood lead levels (11.5 micrograms per dl), followed by Mexican American children (10.4 micrograms per dl) and Cuban children (8.6 micrograms per dl, P less than .05). Puerto Rican children had the highest percent with elevated blood lead (2.7 percent); 1.6 percent of Mexican American children had elevated blood lead; less than 1 percent (0.9 percent) of the Cuban children had elevated blood lead (P less than .05). Mexican American girls had a lower mean blood lead level than did boys: 9.7 micrograms per dl versus 11.0 micrograms per dl (P less than .05). For both Puerto Rican and Mexican American children, younger age indicated a higher risk of having elevated blood lead levels. Mexican American children who lived in poverty had higher mean blood lead levels than did Mexican American children who did not live in poverty--11.6 micrograms per dl versus 9.6 micrograms per dl (P less than .05). Despite advances in primary prevention of lead toxicity in children during the past 10 years, many Hispanic children are at risk of lead toxicity. Approximately 19,000 Mexican American 4-11-year-old children living in the Southwest and approximately 8,000 Puerto Rican children living in the New York City area had elevated blood lead levels (greater than or equal to 25 micrograms per dl) during 1982-84. JF - Public health reports (Washington, D.C. : 1974) AU - Carter-Pokras, O AU - Pirkle, J AU - Chavez, G AU - Gunter, E AD - Centers for Disease Control, Public Health Service. PY - 1990 SP - 388 EP - 393 VL - 105 IS - 4 SN - 0033-3549, 0033-3549 KW - Lead KW - 2P299V784P KW - Abridged Index Medicus KW - Index Medicus KW - New York City KW - Mexico -- ethnology KW - Cuba -- ethnology KW - Puerto Rico -- ethnology KW - Humans KW - Child KW - Florida KW - Southwestern United States KW - Male KW - Female KW - Child, Preschool KW - Hispanic Americans KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79923374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Blood+lead+levels+of+4-11-year-old+Mexican+American%2C+Puerto+Rican%2C+and+Cuban+children.&rft.au=Carter-Pokras%2C+O%3BPirkle%2C+J%3BChavez%2C+G%3BGunter%2C+E&rft.aulast=Carter-Pokras&rft.aufirst=O&rft.date=1990-07-01&rft.volume=105&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-13 N1 - Date created - 1990-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Analyst. 1970 May;95(130):431-8 [5419713] Salud Publica Mex. 1978 May-Jun;20(3):343-5 [582474] N Engl J Med. 1983 Jun 9;308(23):1373-7 [6188954] N Engl J Med. 1982 Sep 2;307(10):573-9 [7110203] Environ Health Perspect. 1979 Aug;31:183-90 [499123] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. AN - 79860497; 2195323 AB - Alkylating agents, because of their ability to react directly with DNA either in vitro or in vivo, or following metabolic activation as in the case of the dialkylnitrosamines, have been used extensively in studying the mechanisms of mutagenicity and carcinogenicity. Their occurrence is widespread in the environment and human exposure from natural and pollutant sources is universal. Since most of these chemicals show varying degrees of both carcinogenicity and mutagenicity, and exhibit compound-specific binding patterns, they provide an excellent model for studying molecular dosimetry. Molecular dosimetry defines dose as the number of adducts bound per macromolecule and relates the binding of these adducts to the human mutagenic or carcinogenic response. This review complies DNA alkylation data for both methylating and ethylating agents in a variety of systems and discusses the role these alkylation products plays in molecular mutagenesis. JF - Mutation research AU - Beranek, D T AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 11 EP - 30 VL - 231 IS - 1 SN - 0027-5107, 0027-5107 KW - Alkylating Agents KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Humans KW - Methylation KW - Alkylation KW - Mutagenicity Tests KW - Alkylating Agents -- metabolism KW - DNA -- metabolism KW - Alkylating Agents -- pharmacology KW - Carcinogenicity Tests KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79860497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Distribution+of+methyl+and+ethyl+adducts+following+alkylation+with+monofunctional+alkylating+agents.&rft.au=Beranek%2C+D+T&rft.aulast=Beranek&rft.aufirst=D&rft.date=1990-07-01&rft.volume=231&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Listeria Species in a California Coast Estuarine Environment AN - 19086681; 9011908 AB - Listeria species and L. monocytogenes were found in 81% and 62%, respectively, of fresh or low-salinity waters (37 samples) in tributaries draining into Humboldt-Arcata Bay, California, during a winter (January-February) sampling period. The incidence of Listeria species and L. monocytogenes in sediment (46 samples) from the same sites where water was sampled was 30.4% and 17.4%, respectively. One of three bay water samples contained Listeria species (including L. monocytogenes), while of 35 samples of oysters examined, only 1 was found positive for Listeria species (L. innocua). A given species or L. monocytogenes serogroup appeared to predominate in freshwater when domesticated animals (cows, horses) were nearby. Greater variety with no species predominance was observed in areas with no direct animal influence. (Author 's abstract) JF - Applied and Environmental Microbiology AEMIDF Vol. 56, No. 7, p 2007-2011, July 1990. 2 fig, 1 tab, 26 ref. AU - Colburn, K G AU - Kaysner, CA AU - Abeyta, C AU - Wekell, M M AD - Food and Drug Administration Bothell, WA. Seafood Products Research Center Y1 - 1990/07// PY - 1990 DA - Jul 1990 KW - Water Resources Abstracts KW - California KW - Coastal waters KW - Estuaries KW - Listeria KW - Nonpoint pollution sources KW - Oysters KW - Pathogenic bacteria KW - Water pollution sources KW - Aquatic bacteria KW - Bays KW - Estuarine sediments KW - Farm wastes KW - Humboldt-Arcata Bay KW - Salinity KW - Spatial distribution KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19086681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Listeria+Species+in+a+California+Coast+Estuarine+Environment&rft.au=Colburn%2C+K+G%3BKaysner%2C+CA%3BAbeyta%2C+C%3BWekell%2C+M+M&rft.aulast=Colburn&rft.aufirst=K&rft.date=1990-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Mandatory reporting of occupational diseases by clinicians. AN - 79863198; 2113987 JF - MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports AU - Freund, E AU - Seligman, P J AU - Chorba, T L AU - Safford, S K AU - Drachman, J G AU - Hull, H F AD - Division of Surveillance, National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, OH 45226. Y1 - 1990/06/22/ PY - 1990 DA - 1990 Jun 22 SP - 19 EP - 28 VL - 39 SN - 1057-5987, 1057-5987 KW - Index Medicus KW - United States KW - Accidents, Occupational -- prevention & control KW - Humans KW - United States Occupational Safety and Health Administration KW - Accidents, Occupational -- legislation & jurisprudence KW - National Institute for Occupational Safety and Health (U.S.) KW - Public Health -- legislation & jurisprudence KW - Occupational Diseases -- prevention & control KW - Role KW - Physician's Role UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79863198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.atitle=Mandatory+reporting+of+occupational+diseases+by+clinicians.&rft.au=Freund%2C+E%3BSeligman%2C+P+J%3BChorba%2C+T+L%3BSafford%2C+S+K%3BDrachman%2C+J+G%3BHull%2C+H+F&rft.aulast=Freund&rft.aufirst=E&rft.date=1990-06-22&rft.volume=39&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.issn=10575987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-06 N1 - Date created - 1990-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acetaminophen-induced alterations in pancreatic beta cells and serum insulin concentrations in B6C3F1 mice. AN - 79862807; 2194324 AB - Administration of acetaminophen (500 mg/kg) to male B6C3F1 mice resulted in alterations of pancreatic beta cell ultrastructure. These alterations were characterized by pronounced intercellular spaces, cytoplasmic vacuolization, damaged membranes of cytoplasm, secretory granules, and other organelles, and pyknotic nuclei with disrupted membranes. Concomitant with these changes, acetaminophen also caused increaes in serum insulin concentrations from 24 microU/ml at 0 time to 160 microU/ml at 8 hr and increases in serum alanine aminotransferase (ALT) concentrations from 42 to 13,279 U/liter, which indicated hepatic damage. Quantitation of 3-(cystein-S-yl)acetaminophen adducts in hepatic 10,000g supernatant protein using a particle concentration fluorescence immunochemical assay indicated a positive correlation between binding and the occurrence of the hepatotoxicity consistent with what has been previously reported; however, 3-(cystein-S-yl)acetaminophen protein adducts were not detected in pancreatic 10,000g supernatant. Immunohistochemical analysis of the liver and pancreas from acetaminophen-treated mice revealed acetaminophen-protein adducts in the centrilobular regions of the liver but not in the pancreatic islets. Doses of 100 and 200 mg/kg produced no evidence of hepatotoxicity and no increase in serum insulin; 300 mg/kg and higher doses produced both hepatotoxicity and increased serum insulin concentrations. A comparison of the time course for the increase in serum levels of ALT and insulin following a toxic dose of acetaminophen indicated that the increase in ALT preceded the increase in insulin. Thus the hepatotoxicity of acetaminophen correlates with the formation of 3-(cystein-S-yl)acetaminophen protein adducts in liver, which supports the concept that this toxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinone imine; however, the toxicity of acetaminophen to beta cells in the pancreas is apparently not mediated by this mechanism. JF - Toxicology and applied pharmacology AU - Ferguson, D V AU - Roberts, D W AU - Han-Shu, H AU - Andrews, A AU - Benson, R W AU - Bucci, T J AU - Hinson, J A AD - National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1990/06/15/ PY - 1990 DA - 1990 Jun 15 SP - 225 EP - 234 VL - 104 IS - 2 SN - 0041-008X, 0041-008X KW - Insulin KW - 0 KW - Proteins KW - Acetaminophen KW - 362O9ITL9D KW - 3-(cystein-S-yl)paracetamol KW - 6Q2X58Y8BP KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Animals KW - Alanine Transaminase -- blood KW - Liver -- drug effects KW - Liver -- metabolism KW - Microscopy, Electron KW - Mice KW - Proteins -- metabolism KW - Male KW - Acetaminophen -- administration & dosage KW - Islets of Langerhans -- ultrastructure KW - Insulin -- blood KW - Islets of Langerhans -- drug effects KW - Acetaminophen -- analogs & derivatives KW - Acetaminophen -- metabolism KW - Islets of Langerhans -- pathology KW - Islets of Langerhans -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79862807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Acetaminophen-induced+alterations+in+pancreatic+beta+cells+and+serum+insulin+concentrations+in+B6C3F1+mice.&rft.au=Ferguson%2C+D+V%3BRoberts%2C+D+W%3BHan-Shu%2C+H%3BAndrews%2C+A%3BBenson%2C+R+W%3BBucci%2C+T+J%3BHinson%2C+J+A&rft.aulast=Ferguson&rft.aufirst=D&rft.date=1990-06-15&rft.volume=104&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-07 N1 - Date created - 1990-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fatal occupational injuries in the United States, 1980 through 1985. AN - 79779390; 2342216 AB - The National Traumatic Occupational Fatality surveillance project was designed to gather demographic, employment, and injury information from death certificates for all deaths due to injuries at work in the United States. Approximately 7000 workers have died each year during the 6-year period from 1980 through 1985: 94% were men, and 6% were women. Unintentional injuries caused the deaths of 83% of the men and 50% of the women. Eleven percent of the men and 39% of the women died from homicide. While the greatest number of deaths occurred in the group aged 20 through 34 years, fatality rates were highest among those aged 70 years and older. Expressed as deaths per 100,000 workers, annual fatality rates for black workers (7.7) were slightly higher than for white workers (6.5). The four industrial groups with the highest fatality rates were mining (31.9); transportation, communication, and public utilities (25.4); construction (24.0); and agriculture, forestry, and fishing (20.7). From 1980 through 1985 the annual traumatic occupational fatality rate fell 23%. JF - JAMA AU - Bell, C A AU - Stout, N A AU - Bender, T R AU - Conroy, C S AU - Crouse, W E AU - Myers, J R AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WVa 26505-2888. Y1 - 1990/06/13/ PY - 1990 DA - 1990 Jun 13 SP - 3047 EP - 3050 VL - 263 IS - 22 SN - 0098-7484, 0098-7484 KW - Abridged Index Medicus KW - Index Medicus KW - Homicide KW - Age Factors KW - Humans KW - Adult KW - Aged KW - Vital Statistics KW - United States -- epidemiology KW - Male KW - Female KW - Population Surveillance KW - Accidents, Occupational -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79779390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Fatal+occupational+injuries+in+the+United+States%2C+1980+through+1985.&rft.au=Bell%2C+C+A%3BStout%2C+N+A%3BBender%2C+T+R%3BConroy%2C+C+S%3BCrouse%2C+W+E%3BMyers%2C+J+R&rft.aulast=Bell&rft.aufirst=C&rft.date=1990-06-13&rft.volume=263&rft.issue=22&rft.spage=3047&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-28 N1 - Date created - 1990-06-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1990 Dec 5;264(21):2737 [2232054] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oncogenes, oncogenesis, and oxygen radicals. AN - 80376625; 2099790 AB - The role that free radicals in general and oxygen radicals in particular play in carcinogenesis has attracted considerable attention in recent years. The oxygen radicals are undesirable but inevitable products of aerobic metabolism in the normal living cell. The cellular antioxidant defense system maintains an appropriate balance between necessary oxidative events and those that are excessive. When this critical balance cannot be maintained because of the overloading of the cellular redox system, oxygen radicals can induce cell damage. They can influence carcinogenesis by inducing DNA damage from direct oxidation or indirectly from DNA-binding products of lipid peroxidation. Oxygen radicals can induce conformational changes in the plasma membrane by lipid peroxidation and protein degradation, thus influencing membrane-associated cellular activities. They are capable of affecting membrane-bound protein kinases, growth factors and their receptors, and, therefore, signal transduction and oncogene activation. Thus, the oxygen radicals can have a major influence on oncogenes and oncogenesis. JF - Biomedical and environmental sciences : BES AU - Sahu, S C AD - Molecular Toxicology Laboratory, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 183 EP - 201 VL - 3 IS - 2 SN - 0895-3988, 0895-3988 KW - Free Radicals KW - 0 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - DNA Damage -- physiology KW - Humans KW - Gene Expression Regulation, Neoplastic -- physiology KW - Cell Membrane -- metabolism KW - Lipid Peroxidation -- physiology KW - Oncogenes -- genetics KW - Cell Transformation, Neoplastic -- metabolism KW - Oxygen -- physiology KW - Oncogenes -- physiology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80376625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+and+environmental+sciences+%3A+BES&rft.atitle=Oncogenes%2C+oncogenesis%2C+and+oxygen+radicals.&rft.au=Sahu%2C+S+C&rft.aulast=Sahu&rft.aufirst=S&rft.date=1990-06-01&rft.volume=3&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Biomedical+and+environmental+sciences+%3A+BES&rft.issn=08953988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cooperative action of insulin and catecholamines on stimulation of ornithine decarboxylase activity in neonatal rat heart cells. AN - 80091169; 2172554 AB - Stimulation of ornithine decarboxylase (ODC) activity was examined in cultured heart cells from neonatal rats. Fetal bovine serum had a concentration-dependent effect on ODC activity with maximum response obtained at 10% serum. ODC activity peaked 4 h after the addition of serum and returned to initial levels at 8 h. In the absence of serum, non-cytotoxic concentrations of the adrenergic agonists epinephrine, norepinephrine or isoproterenol did not stimulate ODC activity. Co-administration of serum and catecholamines at 10(-5) M induced an ODC response that was significantly greater than that induced by serum alone. A screen of various constituents of serum revealed that insulin, though relatively ineffective alone, acted cooperatively with catecholamines to produce an ODC response equivalent to that induced by 10% serum. Propranolol effectively blocked the cooperative effect of insulin on catecholamine stimulation of ODC activity, and markedly inhibited the stimulation of ODC by 10% serum. Insulin also acted cooperatively with the second-messenger analogue dibutyryl-cAMP. The calcium ionophore A23187 significantly increased ODC activity and this response was potentiated by the presence of insulin. The present findings are concordant with in vivo observations in that beta-adrenergic activation stimulates ODC activity in cultured heart cells, but it also demonstrates that the cooperative action of other factors present in serum, such as insulin, are required. JF - Journal of molecular and cellular cardiology AU - Toraason, M AU - Luken, M E AU - Krueger, J A AD - Division of Biomedical and Behavioral Science, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 637 EP - 644 VL - 22 IS - 6 SN - 0022-2828, 0022-2828 KW - Blood Proteins KW - 0 KW - Catecholamines KW - Insulin KW - Calcimycin KW - 37H9VM9WZL KW - Cyclic AMP KW - E0399OZS9N KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Rats KW - Animals KW - Hypertrophy KW - Fibroblasts -- enzymology KW - Cells, Cultured KW - Cyclic AMP -- pharmacology KW - Heart -- drug effects KW - Calcimycin -- pharmacology KW - Drug Synergism KW - Cardiomegaly -- enzymology KW - Isoproterenol -- toxicity KW - Blood Proteins -- pharmacology KW - Isoproterenol -- pharmacology KW - Ornithine Decarboxylase -- metabolism KW - Myocardium -- cytology KW - Catecholamines -- pharmacology KW - Myocardium -- enzymology KW - Insulin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80091169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+and+cellular+cardiology&rft.atitle=Cooperative+action+of+insulin+and+catecholamines+on+stimulation+of+ornithine+decarboxylase+activity+in+neonatal+rat+heart+cells.&rft.au=Toraason%2C+M%3BLuken%2C+M+E%3BKrueger%2C+J+A&rft.aulast=Toraason&rft.aufirst=M&rft.date=1990-06-01&rft.volume=22&rft.issue=6&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+and+cellular+cardiology&rft.issn=00222828&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-04 N1 - Date created - 1990-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Environmental epidemiologic investigations in the styrene-butadiene rubber production industry. AN - 80001077; 2205482 AB - A review of the literature and an update that is in progress of a previous retrospective cohort mortality study of the styrene-1,3-butadiene industry are discussed. The follow-up has now been extended from April 1, 1976, through December 31, 1981, for plant B and December 31, 1982, for plant A. The person-years at risk of death have gone from 34,187 to 43,341 in plant A and from 19,742 to 26,314 in plant B. Among the death certificates received to date, observed deaths have increased in both plants, with increases in cancers of the trachea, bronchus and lung and in lymphosarcomas, reticulosarcomas, and cancers of the overall lymphatic and hematopoietic system. JF - Environmental health perspectives AU - Lemen, R A AU - Meinhardt, T J AU - Crandall, M S AU - Fajen, J M AU - Brown, D P AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 103 EP - 106 VL - 86 SN - 0091-6765, 0091-6765 KW - Butadienes KW - 0 KW - Elastomers KW - Styrenes KW - styrene-butadiene rubber KW - 61789-96-6 KW - Index Medicus KW - Lymphoma -- mortality KW - Tracheal Neoplasms -- mortality KW - Leukemia -- mortality KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Lung Neoplasms -- mortality KW - Bronchial Neoplasms -- mortality KW - Male KW - Chemical Industry KW - Styrenes -- adverse effects KW - Neoplasms -- mortality KW - Neoplasms -- chemically induced KW - Butadienes -- adverse effects KW - Occupational Diseases -- chemically induced KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80001077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+epidemiologic+investigations+in+the+styrene-butadiene+rubber+production+industry.&rft.au=Lemen%2C+R+A%3BMeinhardt%2C+T+J%3BCrandall%2C+M+S%3BFajen%2C+J+M%3BBrown%2C+D+P&rft.aulast=Lemen&rft.aufirst=R&rft.date=1990-06-01&rft.volume=86&rft.issue=&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-26 N1 - Date created - 1990-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Work Environ Health. 1982 Dec;8(4):250-9 [7170621] J Occup Med. 1976 Mar;18(3):178-85 [1255279] Br J Prev Soc Med. 1976 Dec;30(4):225-30 [1009272] J Occup Med. 1987 Aug;29(8):675-80 [3655951] Am J Ind Med. 1987;12(3):311-29 [3674024] Science. 1985 Feb 1;227(4686):548-9 [3966163] Am Ind Hyg Assoc J. 1987 May;48(5):407-13 [3591659] J Occup Med. 1983 Feb;25(2):115-24 [6687607] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Economic implications of a safe food supply. AN - 79937888; 2200815 JF - Journal of dairy science AU - Gill, R W AD - Center for Food Safety and Applied Nutrition, Department of Health and Human Services, Washington, DC 20204. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 1662 EP - 1664 VL - 73 IS - 6 SN - 0022-0302, 0022-0302 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Legislation, Drug KW - Food Inspection KW - Food Contamination -- economics KW - Food Supply -- economics KW - Food Contamination -- legislation & jurisprudence KW - Food Supply -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79937888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dairy+science&rft.atitle=Economic+implications+of+a+safe+food+supply.&rft.au=Gill%2C+R+W&rft.aulast=Gill&rft.aufirst=R&rft.date=1990-06-01&rft.volume=73&rft.issue=6&rft.spage=1662&rft.isbn=&rft.btitle=&rft.title=Journal+of+dairy+science&rft.issn=00220302&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-18 N1 - Date created - 1990-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Polymerase chain reaction for detection of invasive Shigella flexneri in food. AN - 79930567; 2200336 AB - The polymerase chain reaction (PCR) was used to amplify a 760-base-pair (bp) fragment with the 220-kbp invasive plasmids of enteroinvasive Escherichia coli, Shigella flexneri, Shigella dysenteriae, Shigella boydii, and Shigella sonnei as templates. This PCR product was easily detected by agarose gel electrophoresis. A 210-bp AccI-PstI fragment lying within the amplified region was used as a probe in Southern hybridization blots and showed that the PCR-generated product was derived from the invasive plasmid. The application of PCR as a rapid method to detect enteroinvasive bacteria in foods was tested by inoculating lettuce with 10(4) S. flexneri cells per g in shigella broth base. Plasmid DNA was isolated from cultures of inoculated and uninoculated lettuce in broth after 0, 4, and 24 h of incubation. With the PCR, the 760-bp fragment was generated only from lettuce inoculated with S. flexneri, as shown by gel electrophoresis and confirmed both by Southern blotting and by nucleotide sequencing of the amplified region. Because the isolation of plasmid DNA, the performance of PCR, and gel electrophoresis all can be completed in 6 to 7 h, invasive enteric bacteria can be detected in less than 1 day. JF - Applied and environmental microbiology AU - Lampel, K A AU - Jagow, J A AU - Trucksess, M AU - Hill, W E AD - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 1536 EP - 1540 VL - 56 IS - 6 SN - 0099-2240, 0099-2240 KW - Culture Media KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Sensitivity and Specificity KW - Plants, Edible KW - Blotting, Southern KW - Restriction Mapping KW - Escherichia coli -- genetics KW - Polymerase Chain Reaction KW - Food Microbiology KW - Shigella flexneri -- isolation & purification KW - DNA, Bacterial -- isolation & purification KW - Shigella flexneri -- genetics KW - Gene Amplification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79930567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Polymerase+chain+reaction+for+detection+of+invasive+Shigella+flexneri+in+food.&rft.au=Lampel%2C+K+A%3BJagow%2C+J+A%3BTrucksess%2C+M%3BHill%2C+W+E&rft.aulast=Lampel&rft.aufirst=K&rft.date=1990-06-01&rft.volume=56&rft.issue=6&rft.spage=1536&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-11 N1 - Date created - 1990-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 1972 Nov;126(5):523-30 [4197755] Microb Pathog. 1989 May;6(5):337-42 [2770505] Infect Immun. 1981 Oct;34(1):75-83 [6271687] Infect Immun. 1982 Mar;35(3):852-60 [6279518] Infect Immun. 1983 Apr;40(1):340-50 [6299962] Plasmid. 1983 Nov;10(3):296-8 [6657780] J Assoc Off Anal Chem. 1984 Jul-Aug;67(4):801-7 [6381467] Appl Environ Microbiol. 1985 Jun;49(6):1374-8 [3893320] Appl Environ Microbiol. 1985 Aug;50(2):337-41 [3901919] Science. 1985 Dec 20;230(4732):1350-4 [2999980] J Assoc Off Anal Chem. 1986 May-Jun;69(3):531-6 [3522538] Infect Immun. 1986 Aug;53(2):352-8 [3015801] Health Matrix. 1986 Spring;4(1):62-5 [10277606] J Clin Microbiol. 1986 Sep;24(3):498-500 [3531233] Science. 1988 Jan 29;239(4839):487-91 [2448875] J Clin Microbiol. 1988 Feb;26(2):261-6 [2830310] Mol Cell Probes. 1988 Mar;2(1):47-57 [3288864] Am J Epidemiol. 1988 Dec;128(6):1312-21 [3057879] J Clin Microbiol. 1989 Feb;27(2):261-5 [2644292] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk of neuropsychiatric disability among painters in the United States. AN - 79924741; 2382120 AB - Scandinavian studies have suggested that working with solvents is associated with chronic neuropsychiatric disease. In the United States the Social Security Administration's records of white male recipients of disability compensation were used in a case-referent study on this topic. The cases were defined as men with any one of several neuropsychiatric diseases, and the referents as men with other disabling conditions. The men were considered exposed if they had worked as a painter prior to disability and unexposed if they had worked as a bricklayer. A job-exposure matrix verified the painters' potential exposure to solvents and the bricklayers' lack of potential exposure. The painters had a significant excess of neuropsychiatric disability [adjusted odds ratio (OR) 1.42, 95% confidence interval (95% CI) 1.04-1.94]. Construction painters had an excess of neuropsychiatric disability [OR 1.47 (95% CI 1.07-2.02)] in contrast to spray painters [OR 0.77 (95% CI 0.38-1.54)]. The limitations of the data are discussed, including potential diagnosis bias and exposure misclassification. JF - Scandinavian journal of work, environment & health AU - Brackbill, R M AU - Maizlish, N AU - Fischbach, T AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 182 EP - 188 VL - 16 IS - 3 SN - 0355-3140, 0355-3140 KW - Solvents KW - 0 KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Adult KW - Environmental Exposure KW - Case-Control Studies KW - Male KW - Central Nervous System Diseases -- epidemiology KW - Central Nervous System Diseases -- chemically induced KW - Mental Disorders -- epidemiology KW - Mental Disorders -- chemically induced KW - Solvents -- adverse effects KW - Paint -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79924741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Risk+of+neuropsychiatric+disability+among+painters+in+the+United+States.&rft.au=Brackbill%2C+R+M%3BMaizlish%2C+N%3BFischbach%2C+T&rft.aulast=Brackbill&rft.aufirst=R&rft.date=1990-06-01&rft.volume=16&rft.issue=3&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-11 N1 - Date created - 1990-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Coinhibition of viral interferon induction by benzo[a]pyrene in association with occupation-related particles. AN - 79815632; 2351130 AB - Benzo[a]pyrene (B[a]P) in combination with coal, asbestos, or metal particles was studied for its inhibitory effects on interferon-alpha/beta induction by influenza virus in rhesus monkey kidney (LLC-MK2) cell monolayers. B[a]P per se had no adverse effect on the induction process. However, when cell cultures were pretreated with B[a]P that was bioactivated by rat liver S9 homogenate, from 52 to 65% inhibition of interferon induction occurred. Significantly greater (P less than 0.05) depression (coinhibition) of viral interferon induction (greater than 83%) resulted when bioactivated B[a]P was incorporated with coal particles representative of coal rank (anthracite, bituminous, lignite, peat). Coinhibition affected by bioactivated B[a]P was coal rank-independent but any interferon inhibitory activity affected by coal particles per se was coal rank-dependent. When metals (aluminum, aluminum oxide, ferric oxide, nickel, or chromium) or asbestos fibers (chrysotile, crocidolite, anthophyllite, or amosite) were individually mixed with bioactivated B[a]P, coinhibition of cellular interferon synthesis also resulted which was significantly greater (P less than 0.05) than that manifested by bioactivated B[a]P or particles per se. Coinhibition of interferon induction by silicates (Min-U-Sil, DQ-12, hypersthene, or wollastonite) and the bioactivated hydrocarbon was not in evidence although some silicates alone partially inhibited the induction process. Viral interferon induction was inhibited in a dose-response manner by B[a]P (+/- S9) in combination with selected particles. The adsorption of B[a]P to all types of particles was no more than 5.98 micrograms B[a]P/mg of particles and, moreover, less than 0.5% by weight. These findings provide further evidence that bioactivated B[a]P and occupation-related particles act together to coinhibit a biological defense mechanism, the interferon induction phase of the interferon system. JF - Environmental research AU - Hahon, N AU - Booth, J A AU - Flowers, L AD - National Institute for Occupational Safety and Health, ALOSH, Morgantown, West Virginia. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 83 EP - 98 VL - 52 IS - 1 SN - 0013-9351, 0013-9351 KW - Coal KW - 0 KW - Interferon Type I KW - Metals KW - Asbestos KW - 1332-21-4 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Orthomyxoviridae -- drug effects KW - Cocarcinogenesis KW - Orthomyxoviridae -- metabolism KW - Cells, Cultured KW - Macaca mulatta KW - Male KW - Viral Interference KW - Metals -- adverse effects KW - Coal -- adverse effects KW - Liver -- drug effects KW - Interferon Type I -- biosynthesis KW - Benzo(a)pyrene -- toxicity KW - Kidney -- drug effects KW - Liver -- metabolism KW - Asbestos -- adverse effects KW - Benzo(a)pyrene -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79815632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Coinhibition+of+viral+interferon+induction+by+benzo%5Ba%5Dpyrene+in+association+with+occupation-related+particles.&rft.au=Hahon%2C+N%3BBooth%2C+J+A%3BFlowers%2C+L&rft.aulast=Hahon&rft.aufirst=N&rft.date=1990-06-01&rft.volume=52&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-19 N1 - Date created - 1990-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Case-control study of lung cancer and truck driving in the Teamsters Union. AN - 79789440; 1693040 AB - We conducted a case-control study of lung cancer deaths in the Teamsters Union to compare the risk of different occupations within the teamsters, after controlling for smoking and other confounders. Occupations with no presumed exposure to diesel fumes were used as the nonexposed group. The study population consisted of 996 cases and 1,085 controls who had died in 1982-83 after applying for pensions. Next of kin provided information on smoking, work history, and other potential confounders. Work history data were also obtained from the Teamsters Union. While no single job category had a significant excess risk compared to the non-exposed group, certain sub-groups were elevated. The odds ratio for those with long-term employment as long-haul truckers after 1959 (an approximate date for the introduction of diesel engines) was 1.55 (95% CI: 0.97, 2.47). Long-term drivers of primarily diesel trucks had an odds ratio of 1.89 (95% CI: 1.04, 3.42). Overall, our results suggest that diesel truck drivers have an excess risk of lung cancer compared to other teamsters in jobs outside the trucking industry. However, our findings were not uniformly consistent and our data have many limitations, the most important of which is the lack of data on exposure to diesel fumes. JF - American journal of public health AU - Steenland, N K AU - Silverman, D T AU - Hornung, R W AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, OH 45226. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 670 EP - 674 VL - 80 IS - 6 SN - 0090-0036, 0090-0036 KW - Vehicle Emissions KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Epidemiologic Methods KW - Risk Factors KW - Humans KW - Death Certificates KW - Case-Control Studies KW - Male KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Labor Unions KW - Vehicle Emissions -- poisoning KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology KW - Automobile Driving UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79789440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Case-control+study+of+lung+cancer+and+truck+driving+in+the+Teamsters+Union.&rft.au=Steenland%2C+N+K%3BSilverman%2C+D+T%3BHornung%2C+R+W&rft.aulast=Steenland&rft.aufirst=N&rft.date=1990-06-01&rft.volume=80&rft.issue=6&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Dent Off. 1989 Aug;1(4):4, 18 [2629797] Am J Ind Med. 1988;14(4):403-15 [3189356] Am J Epidemiol. 1984 Nov;120(5):769-76 [6093503] Environ Res. 1976 Aug;12(1):110-28 [954703] Am Rev Respir Dis. 1987 Jun;135(6):1242-8 [3592400] Am J Epidemiol. 1987 Jul;126(1):144-6 [3591778] Am J Epidemiol. 1982 Jan;115(1):92-106 [7055134] Int J Epidemiol. 1987 Sep;16(3):341-6 [3667029] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational exposure of workers to 1,3-butadiene. AN - 21344531; 7691294 AB - Researchers from the National Institute for Occupational Safety and Health (NIOSH) conducted an extent-of-exposure study of the 1,3-butadiene monomer, polymer, and end-user industries to determine the size of the exposed workforce, evaluate control technologies and personal protective equipment programs, and assess occupational exposure to 1,3-butadiene. A new analytical method was developed for 1,3-butadiene that increased the sensitivity and selectivity of the previous NIOSH method. The new method is sensitive to 0.2 microgram per 1,3-butadiene sample. Walk-through surveys were conducted in 11 monomer, 17 polymer, and 2 end-user plants. In-depth industrial hygiene surveys were conducted at 4 monomer, 5 polymer, and 2 end-user plants. Airborne exposure concentrations of 1,3-butadiene were determined using personal sampling for each job category. A total of 692 full shift and short-term personnel and 259 area air samples were examined for the presence of 1,3-butadiene. Sample results indicated that all worker exposures were well below the current OSHA PEL of 1000 ppm. Exposures ranged from less than 0.006 ppm to 374 ppm. The average exposure for all samples was less than 2 ppm. The present American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value for 1,3-butadiene is 10 ppm. To reduce the potential for occupational exposure, it is recommended that quality control sampling be conducted using a closed loop system. Also all process pumps should be retrofitted with dual mechanical seals, magnetic gauges should be used in loading and unloading rail cars, and engineering controls should be designed for safely voiding quality control cylinders. JF - Environmental Health Perspectives AU - Fajen, J M AU - Roberts, D R AU - Ungers, L J AU - Krishnan, E R AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1990/06// PY - 1990 DA - Jun 1990 SP - 11 EP - 18 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 VL - 86 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts KW - Occupational safety KW - Threshold limits KW - seals KW - Air sampling KW - Occupational exposure KW - Sensitivity KW - Federal regulations KW - Conferences KW - Protective equipment KW - Quality control KW - safety regulations KW - Pumps KW - Hygiene KW - Polymers KW - Technology KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21344531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Occupational+exposure+of+workers+to+1%2C3-butadiene.&rft.au=Fajen%2C+J+M%3BRoberts%2C+D+R%3BUngers%2C+L+J%3BKrishnan%2C+E+R&rft.aulast=Fajen&rft.aufirst=J&rft.date=1990-06-01&rft.volume=86&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Polymers; Quality control; Conferences; seals; Hygiene; Pumps; Threshold limits; Air sampling; Federal regulations; safety regulations; Protective equipment; Sensitivity; Occupational safety; Technology ER - TY - JOUR T1 - Inhibition of rat heart mitochondrial electron transport in vitro: implications for the cardiotoxic action of allylamine or its primary metabolite, acrolein. AN - 79791825; 2343460 AB - Allylamine (3-aminopropene) is a specific cardiac toxicant that causes aortic, valvular and myocardial lesions in many species. Myocardial necrosis can be observed 24 h after a single dose. Acute toxicity is believed to involve metabolism of allylamine to highly reactive acrolein (2-propenal). Allylamine has been shown to bind to mitochondria from aorta and heart, suggesting that the subcellular site of injury is at or near the mitochondrion. The present investigation compared the effect of allylamine and its primary metabolite, acrolein, on electron transport and oxidative phosphorylation in mitochondria isolated from rat heart (RHM). Both compounds weakly inhibited mitochondrial electron transport with either the combination of glutamate, malate, and malonate (GMM, NADH-linked) or succinate as substrate. Comparisons of the slopes of concentration-effect regression (range of concentrations tested, 0.20-2.0 mM) lines showed acrolein to have significantly greater inhibitory effects than allylamine (range of concentrations tested, 0.22-6.4 mM) on GMM oxidation, while no significant difference in the abilities of the compounds to inhibit succinate oxidation were observed, indicating site preferences for inhibitory action. The addition of an uncoupling agent could not reverse inhibition with either substrate system. These results indicate that both the parent compound and its proposed metabolite primarily inhibit electron transport with little direct effect on the coupling mechanism. The State III EC50 (effective concentrations for 50% inhibition of control mitochondrial enzyme activities) for allylamine (2.29 mM with succinate as substrate and 1.22 mM with GMM) and acrolein (0.80 mM with succinate as substrate and 0.39 mM with GMM) are probably too great to invoke the direct action of either the parent compound or its oxidized metabolite on mitochondrial electron transport as a primary mechanism in the cardiotoxic action of allylamine. JF - Toxicology AU - Biagini, R E AU - Toraason, M A AU - Lynch, D W AU - Winston, G W AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH. Y1 - 1990/05/14/ PY - 1990 DA - 1990 May 14 SP - 95 EP - 106 VL - 62 IS - 1 SN - 0300-483X, 0300-483X KW - Aldehydes KW - 0 KW - Amines KW - Allylamine KW - 48G762T011 KW - Acrolein KW - 7864XYD3JJ KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Oxidative Phosphorylation -- drug effects KW - In Vitro Techniques KW - Male KW - Electron Transport -- drug effects KW - Aldehydes -- toxicity KW - Amines -- toxicity KW - Mitochondria, Heart -- enzymology KW - Allylamine -- toxicity KW - Mitochondria, Heart -- drug effects KW - Acrolein -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79791825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Inhibition+of+rat+heart+mitochondrial+electron+transport+in+vitro%3A+implications+for+the+cardiotoxic+action+of+allylamine+or+its+primary+metabolite%2C+acrolein.&rft.au=Biagini%2C+R+E%3BToraason%2C+M+A%3BLynch%2C+D+W%3BWinston%2C+G+W&rft.aulast=Biagini&rft.aufirst=R&rft.date=1990-05-14&rft.volume=62&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-27 N1 - Date created - 1990-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development of speech-language-hearing services in Guam and Micronesia. AN - 85145463; pmid-2186732 AB - Even after more than two decades of service delivery by members of this profession, the availability of limited federal funds, and the applicability of federal mandates, services within the region continue to be clearly inadequate. To assure that these inadequacies do not continue indefinitely into the future requires that members of this profession respond to the challenges and overcome the existing barriers and obstacles. JF - ASHA AU - Stewart, J L AU - Triolo, D J AD - Sensory Disabilities Program, Indian Health Service-Headquarters West, Albuquerque, New Mexico. PY - 1990 SP - 37 EP - 39 VL - 32 IS - 5 SN - 0001-2475, 0001-2475 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85145463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ASHA&rft.atitle=Development+of+speech-language-hearing+services+in+Guam+and+Micronesia.&rft.au=Stewart%2C+J+L%3BTriolo%2C+D+J&rft.aulast=Stewart&rft.aufirst=J&rft.date=1990-05-01&rft.volume=32&rft.issue=5&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=ASHA&rft.issn=00012475&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Real-ear attenuation of earmuffs in normal-hearing and hearing-impaired individuals. AN - 85144592; pmid-2348018 AB - Many of the 9 million workers exposed to average noise levels of 85 dB (A) and above are required to wear hearing protection devices, and many of these workers have already developed noise-induced hearing impairments. There is some evidence in the literature that hearing-impaired users may not receive as much attenuation from hearing protectors as normal-hearing users. This study assessed real-ear attenuation at threshold for ten normal-hearing and ten hearing-impaired subjects using a set of David Clark 10A earmuffs. Testing procedures followed the specifications of ANSI S12.6-1984. The results showed that the hearing-impaired subjects received slightly more attenuation than the normal-hearing subjects at all frequencies, but these differences were not statistically significant. These results provide additional support to the finding that hearing protection devices are capable of providing as much attenuation to hearing-impaired users as they do to normal-hearing individuals. JF - The Journal of the Acoustical Society of America AU - Suter, A H AU - Lempert, B L AU - Franks, John Richard AD - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226.; Department of Speech and Hearing Science, College of Social and Behavioral Sciences, Colleges of the Arts and Sciences, Ohio State University PY - 1990 SP - 2114 EP - 2117 VL - 87 IS - 5 SN - 0001-4966, 0001-4966 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85144592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Real-ear+attenuation+of+earmuffs+in+normal-hearing+and+hearing-impaired+individuals.&rft.au=Suter%2C+A+H%3BLempert%2C+B+L%3BFranks%2C+John+Richard&rft.aulast=Suter&rft.aufirst=A&rft.date=1990-05-01&rft.volume=87&rft.issue=5&rft.spage=2114&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Developmental toxicology of industrial alcohols: a summary of 13 alcohols administered by inhalation to rats. AN - 80112270; 2237924 AB - The developmental toxicology of 13 industrial alcohols (methanol, ethanol, 1-propanol, isopropanol, 1-butanol, 2-butanol, tertiary-butanol, 1-pentanol, 1-hexanol, 2-ethyl-1-hexanol, 1-octanol, 1-nonanol, and 1-decanol), and the behavioral teratogenicity of 4 of these alcohols, were assessed in a series of experiments. The results of individual alcohols have been published previously, but the present paper summarizes the results in view of structure-activity relationships among these alcohols. The alcohols were administered by inhalation for 7 hours per day (6 hours/day for 1-decanol) on gestation days 1-19 to groups of approximately 15 pregnant Sprague-Dawley rats. For developmental toxicology evaluations, dams were sacrificed on gestation day 20. Fetuses were serially removed, weighed, sexed, and examined for external malformations. The frequency of visceral malformations and variations was determined in one-half of the fetuses, and the frequency of skeletal deviations was determined in the other half. Behavioral teratology endpoints were investigated in groups of 15 pregnant rats exposed to one of four alcohols (ethanol, 1-propanol, 1-butanol, and tertiary-butanol) and also involved groups of 18 male rats which were exposed to the same concentrations of each alcohol for 6 weeks, and then mated to untreated females. In the behavioral teratology evaluations, all litters were culled to eight pups and fostered to unexposed mothers. Offspring were tested from days 10-90 on a series of behavioral tests designed to evaluate neuromotor integrity, activity levels, learning, and memory. Additionally, brains were removed from 10 offspring per group at 21 days of age, and were dissected into cerebrum, cerebellum, brainstem, and midbrain; these samples were assayed for steady-state levels of protein and the neurotransmitters acetylcholine, dopamine, norepinephrine, 5-hydroxytryptamine (serotonin), substance P, B-endorphin, and met-enkephalin. Congenital malformations were noted for methanol, 1-propanol, isopropanol, and 1-butanol, but only at concentrations in excess of 5000 ppm. These concentrations also produced toxicity in the maternal animals; thus, there was little evidence of selective developmental toxicity among the alcohols. Although sporadic behavioral and neurochemical deviations were detected, no consistent pattern of effects was seen for any of the alcohols we tested. It should be noted that alcohols with chain lengths longer than the butyl series could not be generated as vapors at sufficiently high concentrations to produce observable toxicity in the maternal animals. This limits the generality of these findings to the possible developmental effects of these alcohols when taken through other routes of exposure.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Toxicology and industrial health AU - Nelson, B K AU - Brightwell, W S AU - Krieg, E F AD - Division of Biomedical and Behavioral Science National Institute for Occupational Safety and Health, Cincinnati, OH 45226. PY - 1990 SP - 373 EP - 387 VL - 6 IS - 3-4 SN - 0748-2337, 0748-2337 KW - Alcohols KW - 0 KW - Teratogens KW - Index Medicus KW - Rats KW - Molecular Structure KW - Behavior, Animal -- drug effects KW - Animals KW - Administration, Inhalation KW - Female KW - Structure-Activity Relationship KW - Pregnancy KW - Alcohols -- administration & dosage KW - Alcohols -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80112270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Developmental+toxicology+of+industrial+alcohols%3A+a+summary+of+13+alcohols+administered+by+inhalation+to+rats.&rft.au=Nelson%2C+B+K%3BBrightwell%2C+W+S%3BKrieg%2C+E+F&rft.aulast=Nelson&rft.aufirst=B&rft.date=1990-05-01&rft.volume=6&rft.issue=3-4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-11 N1 - Date created - 1990-12-11 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Subchronic inhalation of triethylamine vapor in Fischer-344 rats: organ system toxicity. AN - 80112108; 2237926 AB - Male and female F-344 rats were exposed at 0, 25, or 247 ppm triethylamine (TEA) vapor, 6 hr per day, 5 days per week for up to 28 weeks in order to characterize the subchronic organ system toxicity. Rats were weighed biweekly and scheduled sacrifices were performed following about 30, 60, and 120 days of exposure. No statistically significant treatment-related effects on organ weights, hematology, clinical chemistry, or electrocardiographic indices were observed. Body weight gain was not affected by TEA treatment. No physiologic or pathologic evidence of cardiotoxicity was seen in rats exposed to either TEA concentration for up to 28 weeks. No gross or histopathologic lesions attributable to TEA exposure were noted in any of the organs examined, including the nasal passages. This latter finding is in marked contrast to previously reported findings from this laboratory in which squamous metaplasia, suppurative rhinitis, and lymphoid hyperplasia were found in the respiratory epithelium of F-344 rats exposed to the structurally related chemical, diethylamine, under the same conditions as this study (Lynch et al., 1986). JF - Toxicology and industrial health AU - Lynch, D W AU - Moorman, W J AU - Lewis, T R AU - Stober, P AU - Hamlin, R D AU - Schueler, R L AD - Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. PY - 1990 SP - 403 EP - 414 VL - 6 IS - 3-4 SN - 0748-2337, 0748-2337 KW - Ethylamines KW - 0 KW - triethylamine KW - VOU728O6AY KW - Index Medicus KW - Rats KW - Hematologic Tests KW - Animals KW - Rats, Inbred F344 KW - Administration, Inhalation KW - Time Factors KW - Male KW - Female KW - Organ Size -- drug effects KW - Electrocardiography -- drug effects KW - Ethylamines -- toxicity KW - Ethylamines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80112108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Subchronic+inhalation+of+triethylamine+vapor+in+Fischer-344+rats%3A+organ+system+toxicity.&rft.au=Lynch%2C+D+W%3BMoorman%2C+W+J%3BLewis%2C+T+R%3BStober%2C+P%3BHamlin%2C+R+D%3BSchueler%2C+R+L&rft.aulast=Lynch&rft.aufirst=D&rft.date=1990-05-01&rft.volume=6&rft.issue=3-4&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-11 N1 - Date created - 1990-12-11 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - A patient-equivalent attenuation phantom for estimating patient exposures from automatic exposure controlled x-ray examinations of the abdomen and lumbo-sacral spine. AN - 79941847; 2385202 AB - The Joint Commission on Accreditation of Healthcare Organizations requires diagnostic radiology facilities to known the approximate amount of radiation received by an average patient during radiographic examinations at the facility. Automatic exposure controlled (AEC) techniques are used for many of these exams, and a standard patient-equivalent phantom is necessary when estimating patient exposure on such systems. This is of particular importance if exposures are to be compared among AEC systems with different entrance x-ray spectra. We have developed a phantom, LucA1 Abdomen, to facilitate determining the average patient exposure from AEC anteroposterior (AP) abdomen and lumbo-sacral (LS) spine radiography. The phantom is relatively lightweight, transportable, sturdy, and made of readily available inexpensive materials (Lucite and aluminum). It accurately simulates the primary and scatter transmission through the soft tissue and L-4 spinal regions of a patient-equivalent anthropomorphic phantom for x-ray spectra typically used in abdomen/LS spine radiography. A clinical evaluation to verify the patient-equivalence of three commercial anthropomorphic phantoms (Humanoid, Rando, 3-M) and two acrylic/aluminum phantoms (ANSI and LucA1 Abdomen) has been conducted. The design and development of the LucA1 Abdomen phantom and the evaluation of all phantoms is described. JF - Medical physics AU - Conway, B J AU - Duff, J E AU - Fewell, T R AU - Jennings, R J AU - Rothenberg, L N AU - Fleischman, R C AD - Food and Drug Administration, Center for Devices and Radiological Health, Rockville, Maryland 20857. PY - 1990 SP - 448 EP - 453 VL - 17 IS - 3 SN - 0094-2405, 0094-2405 KW - Index Medicus KW - Spine -- diagnostic imaging KW - Humans KW - Radiography, Abdominal KW - Radiography -- standards KW - Radiation Dosage KW - Models, Structural KW - Radiography -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79941847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=A+patient-equivalent+attenuation+phantom+for+estimating+patient+exposures+from+automatic+exposure+controlled+x-ray+examinations+of+the+abdomen+and+lumbo-sacral+spine.&rft.au=Conway%2C+B+J%3BDuff%2C+J+E%3BFewell%2C+T+R%3BJennings%2C+R+J%3BRothenberg%2C+L+N%3BFleischman%2C+R+C&rft.aulast=Conway&rft.aufirst=B&rft.date=1990-05-01&rft.volume=17&rft.issue=3&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-14 N1 - Date created - 1990-09-14 N1 - Date revised - 2017-02-16 N1 - Last updated - 2017-02-16 ER - TY - JOUR T1 - The induction of aneuploidy by 3-nitrobenzo[a]pyrene in Chinese hamster ovary cells. AN - 79938902; 2166895 AB - Nitrobenzo[a]pyrenes are found in urban air particulates and particulates from diesel exhaust, gasoline engines and wood burning stoves. Following exposure of Chinese hamster ovary cells (CHO-K1-BH4) to 3-nitrobenzo[a]pyrene (3-NB[a]P), cells with multiple nuclei and/or nuclei with multiple lobes were observed. When CHO cells were treated with 5 micrograms/ml 3-NB[a]P for 5 or 20 h, aneuploidy was noted in these cells at 24-96 h post-exposure. The addition of N6, O2'-dibutyryl adenosine 3':5'-cyclic monophosphate to 3-NB[a]P-exposed CHO cell cultures appeared to reduce the amount of aneuploidy in treated cultures. Structure--activity studies showed that 1-NB[a]P was a much less effective inducer of aneuploidy than 3-NB[a]P and 6-NB[a]P was ineffective. 1-, 3- and 6-nitrosobenzo[a]pyrenes were not effective inducers of aneuploidy in CHO cells, and aneuploidy was not observed in cultures treated with 3-NB[a]P in the presence of S9 activation. It appears that the parent 3-NB[a]P is responsible for producing aneuploidy in CHO cells. JF - Mutagenesis AU - Neft, R E AU - Schol, H M AU - Fu, P P AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 221 EP - 227 VL - 5 IS - 3 SN - 0267-8357, 0267-8357 KW - Benzopyrenes KW - 0 KW - Mutagens KW - 3-nitrobenzo(a)pyrene KW - 70021-98-6 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Animals KW - Gene Frequency KW - Cricetulus KW - Biotransformation KW - In Vitro Techniques KW - Cyclic AMP -- pharmacology KW - Female KW - Cricetinae KW - Ovary -- metabolism KW - Aneuploidy KW - Ovary -- cytology KW - Ovary -- drug effects KW - Benzopyrenes -- pharmacology KW - Chromosomes -- ultrastructure KW - Chromosomes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79938902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=The+induction+of+aneuploidy+by+3-nitrobenzo%5Ba%5Dpyrene+in+Chinese+hamster+ovary+cells.&rft.au=Neft%2C+R+E%3BSchol%2C+H+M%3BFu%2C+P+P%3BCasciano%2C+D+A&rft.aulast=Neft&rft.aufirst=R&rft.date=1990-05-01&rft.volume=5&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-20 N1 - Date created - 1990-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Failure of acrolein to produce sensitization in the guinea pig maximization test. AN - 79930717; 2383990 JF - Contact dermatitis AU - Susten, A S AU - Breitenstein, M J AD - Public Health Service Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 299 EP - 300 VL - 22 IS - 5 SN - 0105-1873, 0105-1873 KW - Aldehydes KW - 0 KW - Acrolein KW - 7864XYD3JJ KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Disease Models, Animal KW - Female KW - Acrolein -- immunology KW - Aldehydes -- adverse effects KW - Dermatitis, Contact -- immunology KW - Dermatitis, Contact -- etiology KW - Acrolein -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79930717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contact+dermatitis&rft.atitle=Failure+of+acrolein+to+produce+sensitization+in+the+guinea+pig+maximization+test.&rft.au=Susten%2C+A+S%3BBreitenstein%2C+M+J&rft.aulast=Susten&rft.aufirst=A&rft.date=1990-05-01&rft.volume=22&rft.issue=5&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Contact+dermatitis&rft.issn=01051873&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-18 N1 - Date created - 1990-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of two immunochemical methods with thin-layer chromatographic methods for determination of aflatoxins. AN - 79905093; 2376547 AB - Three different methods were compared for the determination of total flatoxins in corn and peanuts naturally contaminated with aflatoxins and in corn, peanuts, cottonseed, peanut butter, and poultry feed spiked with aflatoxins B1, B2, and G1. The 3 methods were an enzyme-linked immunosorbent assay (ELISA) screening test; a monoclonal antibody-affinity column-solid-phase separation method; and the AOAC official thin-layer chromatography (TLC) methods for all except poultry feed, for which Shannon's TLC method for mixed feed was used. The ELISA test is designed to provide only positive results for total aflatoxins at greater than or equal to 20 ng/g or negative results at less than 20 ng/g. The affinity column separation is coupled with either bromination solution fluorometry to estimate total aflatoxins or liquid chromatography (LC) to quantitate individual aflatoxins. Fluorodensitometry was used to determine aflatoxins in commodities analyzed by the TLC methods. The LC and TLC results were in good agreement for all the analyses. The results for the affinity column using bromination solution fluorometry were similar except those for cottonseed, which were about 60% higher. The ELISA screening method correctly identified naturally contaminated corn and peanut positive samples. No false positives were found for controls. The correct response for spiked corn, raw peanuts, peanut butter, and cottonseed at greater than or equal to 20 ng aflatoxins/g was about 90%. The correct response for spiked poultry feed at greater than or equal to 20 ng aflatoxins/g was about 50%. JF - Journal - Association of Official Analytical Chemists AU - Trucksess, M W AU - Young, K AU - Donahue, K F AU - Morris, D K AU - Lewis, E AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1990 SP - 425 EP - 428 VL - 73 IS - 3 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Antibodies, Monoclonal KW - Index Medicus KW - Spectrometry, Fluorescence KW - Arachis -- analysis KW - Food Analysis KW - Food Contamination -- analysis KW - Animal Feed -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Antibodies, Monoclonal -- analysis KW - Chromatography, Thin Layer KW - Zea mays -- analysis KW - Immunochemistry KW - Gossypium -- analysis KW - Aflatoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79905093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Comparison+of+two+immunochemical+methods+with+thin-layer+chromatographic+methods+for+determination+of+aflatoxins.&rft.au=Trucksess%2C+M+W%3BYoung%2C+K%3BDonahue%2C+K+F%3BMorris%2C+D+K%3BLewis%2C+E&rft.aulast=Trucksess&rft.aufirst=M&rft.date=1990-05-01&rft.volume=73&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-04 N1 - Date created - 1990-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Survey of lead and cadmium in adult canned foods eaten by young children. AN - 79904272; 2376536 AB - A U.S. Food and Drug Administration survey of lead and cadmium in 10 adult canned foods commonly eaten by children less than 5 years old was conducted between October 1981 and September 1985. The survey, which included foods preserved by a commercial canning process and packaged in metal containers, found the highest mean levels of lead (0.32 micrograms/g) in tuna and of cadmium (0.02 micrograms/g) in tuna and tomatoes. Lead levels in foods packaged in lead-soldered cans were about 5 times as high as those in foods packaged in nonlead-soldered cans. Mean lead levels appeared to decline over the 4 years of the study. Cadmium levels were usually below the data reporting limit (0.01 micrograms/g). JF - Journal - Association of Official Analytical Chemists AU - Capar, S G AD - U.S. Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1990 SP - 357 EP - 364 VL - 73 IS - 3 SN - 0004-5756, 0004-5756 KW - Cadmium KW - 00BH33GNGH KW - Lead KW - 2P299V784P KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Adult KW - Child KW - Cadmium -- analysis KW - Food Contamination KW - Lead -- analysis KW - Food Preservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79904272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Survey+of+lead+and+cadmium+in+adult+canned+foods+eaten+by+young+children.&rft.au=Capar%2C+S+G&rft.aulast=Capar&rft.aufirst=S&rft.date=1990-05-01&rft.volume=73&rft.issue=3&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-04 N1 - Date created - 1990-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of N-nitroso compounds by high-performance liquid chromatography with postcolumn reaction and a thermal energy analyzer. AN - 79895337; 2374408 AB - Carcinogenic nonvolatile N-nitroso compounds have been difficult to determine in foods and other consumer products because of the incompatibility of aqueous high-performance liquid chromatography (HPLC) mobile phases with the thermal energy analyzer (TEA), a sensitive and selective detector for N-nitroso compounds. A postcolumn technique has been developed that permits the use of aqueous mobile phases with an interfaced liquid chromatograph/TEA. This system was linear from 3.5 to 900 ng of N-nitrosoproline injected. Coefficients of variation of 3.0 and 5.1%, respectively, were obtained when N-nitrosoproline and N-nitrosotrimethylurea were repeatedly injected at the 80- to 90-ng level. Mixtures of volatile and nonvolatile N-nitroso compounds as well as N-nitrosodipeptides were separated and quantitated by HPLC/TEA with a water/acetonitrile gradient. JF - Journal of analytical toxicology AU - Havery, D C AD - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204. PY - 1990 SP - 181 EP - 185 VL - 14 IS - 3 SN - 0146-4760, 0146-4760 KW - Nitroso Compounds KW - 0 KW - Potassium Iodide KW - 1C4QK22F9J KW - Index Medicus KW - Evaluation Studies as Topic KW - Chromatography, High Pressure Liquid -- methods KW - Thermal Conductivity KW - Nitroso Compounds -- analysis KW - Chemistry Techniques, Analytical -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79895337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Determination+of+N-nitroso+compounds+by+high-performance+liquid+chromatography+with+postcolumn+reaction+and+a+thermal+energy+analyzer.&rft.au=Havery%2C+D+C&rft.aulast=Havery&rft.aufirst=D&rft.date=1990-05-01&rft.volume=14&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-30 N1 - Date created - 1990-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Paradoxical bronchospasm associated with the use of inhaled beta agonists. AN - 79752960; 1970585 AB - Adverse reaction reports for inhaled relatively beta 2-selective, adrenergic-agonist bronchodilators submitted to the Center for Drug Evaluation and Research of the Food and Drug Administration between 1974 and 1988 were reviewed. There were 126 reports associated with the use of these drugs by metered-dose inhaler, which were consistent with a diagnosis of paradoxical bronchospasm. In addition, 58 such reports were received for these drugs delivered as a solution for nebulization between 1983 and 1988. Increased reporting of reactions consistent with paradoxical bronchospasm generally correlated with increased availability of these products during the same time period, although there has not been a steady upward trend in such reports for metered-dose inhalers during the past 3 years, despite increasing distribution figures. Despite the apparent infrequency of inhaler-induced paradoxical bronchospasm, the potentially life-threatening nature of such reactions makes awareness of this possibility essential. Patients who report that an inhaled beta-adrenergic agonist makes their asthma worse, as well as the patients who fail to demonstrate expected improvement with this form of therapy, should be suspected of having developed paradoxical bronchospasm. JF - The Journal of allergy and clinical immunology AU - Nicklas, R A AD - Office of Drug Evaluation and Research, Food and Drug Administration, Rockville, Md. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 959 EP - 964 VL - 85 IS - 5 SN - 0091-6749, 0091-6749 KW - Adrenergic beta-Agonists KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Nebulizers and Vaporizers KW - Humans KW - Adrenergic beta-Agonists -- adverse effects KW - Adrenergic beta-Agonists -- administration & dosage KW - Bronchial Spasm -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79752960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Paradoxical+bronchospasm+associated+with+the+use+of+inhaled+beta+agonists.&rft.au=Nicklas%2C+R+A&rft.aulast=Nicklas&rft.aufirst=R&rft.date=1990-05-01&rft.volume=85&rft.issue=5&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-07 N1 - Date created - 1990-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Allergy Clin Immunol. 1991 Sep;88(3 Pt 1):422-3 [1679769] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of rat primary lung cells for studying genotoxicity with the sister-chromatid exchange and micronucleus assays. AN - 79743442; 2333086 AB - Primary culture of lung cells from CD rats was established for pulmonary genotoxicity studies using two genetic endpoints, sister-chromatid exchange (SCE) and micronucleus formation (MN). In the cell isolation study, a combined enzyme separation of rat lungs with trypsin (1.3 mg/ml) plus collagenase (50 U/ml) gave the highest yield of viable and colony-forming cells. For the MN assay, the cytokinesis block induced by cytochalasin B (CYB) was employed to enumerate MN in binucleated (BN) cells. Treatment of primary lung cells with 2 micrograms CYB/ml for two days appeared to be optimal for scoring micronuclei in CYB-induced BN cells. By this procedure, mitomycin C (MMC), triethylenemelamine, and benzo[a]pyrene caused a dose-related increase in micronucleated BN cells in vitro without metabolic activation. In the SCE assay, maximum second-division metaphases were obtained after cells were incubated with bromodeoxyuridine for 48-54 h. After this incubation time, high frequencies of SCE induced by MMC and 3-methylcholanthrene after in vitro exposure (without S9 activation) or in vivo exposure were observed. The results indicate that rat primary lung cells can metabolize polycyclic aromatic hydrocarbons and that this lung cell system is potentially useful for the detection of pulmonary genotoxicants. JF - Mutation research AU - Whong, W Z AU - Stewart, J D AU - Ong, T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 7 EP - 13 VL - 241 IS - 1 SN - 0027-5107, 0027-5107 KW - Mitomycins KW - 0 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochalasin B KW - 3CHI920QS7 KW - Methylcholanthrene KW - 56-49-5 KW - Triethylenemelamine KW - F7IY6HZG9D KW - Index Medicus KW - Triethylenemelamine -- toxicity KW - Rats, Inbred Strains KW - Rats KW - Mitomycins -- toxicity KW - Animals KW - Methylcholanthrene -- toxicity KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Benzo(a)pyrene -- toxicity KW - Cell Division -- drug effects KW - Cytochalasin B -- toxicity KW - Male KW - Micronucleus Tests -- methods KW - Sister Chromatid Exchange -- drug effects KW - Lung -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79743442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Use+of+rat+primary+lung+cells+for+studying+genotoxicity+with+the+sister-chromatid+exchange+and+micronucleus+assays.&rft.au=Whong%2C+W+Z%3BStewart%2C+J+D%3BOng%2C+T&rft.aulast=Whong&rft.aufirst=W&rft.date=1990-05-01&rft.volume=241&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-07 N1 - Date created - 1990-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective elimination in vitro of alloresponsive T cells to human transplantation antigens by toxin or radionuclide conjugated anti-IL-2 receptor (Tac) monoclonal antibody. AN - 79732852; 2139454 AB - The human allogeneic mixed lymphocyte reaction is the in vitro correlate of graft rejection. Cytotoxic effector cells generated during an allogeneic mixed lymphocyte reaction were previously shown to express the human p55 IL-2 receptor subunit, whereas resting cells do not express this receptor peptide. In this study, we asked whether Pseudomonas exotoxin or bismuth-212 (an alpha-particle emitting radionuclide) coupled to the anti-IL-2 receptor mAb, anti-Tac, were able to selectively eliminate alloresponsive cells generated during an allogeneic mixed lymphocyte reaction. After assembly, anti-Tac immunoconjugates retained their binding integrity, specificity, and selectivity. Deletion of alloresponsive cells was shown by the removal of alloproliferating cells as assessed by quantitating cell recovery and by measurement of thymidine incorporation into newly synthesized DNA. Both toxin and radionuclide immunoconjugates eliminated established cytotoxic effector cells generated in an allogeneic mixed lymphocyte reaction, while leaving intact the PHA-inducible mitogenic response of the nonactivated cells. The addition of excess anti-Tac blocked all of the effects of these cytotoxic reagents. The therapeutic reagents in vitro were most effective when added just prior to the peak of the alloproliferative response, when receptor expression would be close to maximum. Thus, anti-Tac conjugated either with toxin or radionuclide is effective in vitro in specifically eliminating cytotoxic effector cells. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Kozak, R W AU - Fitzgerald, D P AU - Atcher, R W AU - Goldman, C K AU - Nelson, D L AU - Gansow, O A AU - Pastan, I AU - Waldmann, T A AD - Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/05/01/ PY - 1990 DA - 1990 May 01 SP - 3417 EP - 3423 VL - 144 IS - 9 SN - 0022-1767, 0022-1767 KW - Bacterial Toxins KW - 0 KW - Exotoxins KW - Immunotoxins KW - Isoantigens KW - Radioisotopes KW - Receptors, Interleukin-2 KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Bismuth KW - U015TT5I8H KW - Abridged Index Medicus KW - Index Medicus KW - Protein Biosynthesis KW - Cytotoxicity, Immunologic KW - Lymphocyte Culture Test, Mixed KW - In Vitro Techniques KW - Isoantigens -- immunology KW - Antibody Formation KW - Cell Survival KW - Cell Division KW - Bismuth -- administration & dosage KW - T-Lymphocytes -- cytology KW - Exotoxins -- administration & dosage KW - Immunotoxins -- administration & dosage KW - T-Lymphocytes -- immunology KW - Receptors, Interleukin-2 -- immunology KW - Radioisotopes -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79732852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Selective+elimination+in+vitro+of+alloresponsive+T+cells+to+human+transplantation+antigens+by+toxin+or+radionuclide+conjugated+anti-IL-2+receptor+%28Tac%29+monoclonal+antibody.&rft.au=Kozak%2C+R+W%3BFitzgerald%2C+D+P%3BAtcher%2C+R+W%3BGoldman%2C+C+K%3BNelson%2C+D+L%3BGansow%2C+O+A%3BPastan%2C+I%3BWaldmann%2C+T+A&rft.aulast=Kozak&rft.aufirst=R&rft.date=1990-05-01&rft.volume=144&rft.issue=9&rft.spage=3417&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-25 N1 - Date created - 1990-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Multicriteria Location of Thermal Power Plants AN - 204112253; 00500865 AB - A case study was carried out by Electricite de France International in Algeria. The problem involved selecting the best sites in 3 coastal regions for installing thermal power plants. The problem was formulated, the criteria were estimated and quantified, and the selection was achieved using the Electre III method. The study was conducted in several stages, with the number of potential sites reduced and a number of criteria examined at each stage. The Electre III method made it possible to consider numerous aspects of the site choice problem and to integrate those aspects into the decision-making process. It allowed the selection of the best site and alternate solutions. It was shown that the Electre III method is entirely suitable for industrial siting problems. JF - European Journal of Operational Research AU - Barda, O Haluk AU - Dupuis, Joseph AU - Lencioni, Pierre Y1 - 1990/04/13/ PY - 1990 DA - 1990 Apr 13 SP - 332 CY - Amsterdam PB - Elsevier Sequoia S.A. VL - 45 IS - 2,3 SN - 03772217 KW - Computers KW - Thermal energy KW - Site selection KW - Power plants KW - Mathematical models KW - Electric utilities KW - Decision making KW - Case studies KW - France KW - North Africa KW - 9177:Africa KW - 9175:Western Europe KW - 9110:Company specific/case studies KW - 2310:Planning KW - 8340:Electric, water & gas utilities, including waste management industry (seel also 1540) KW - 2600:Management science/operations research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/204112253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Operational+Research&rft.atitle=Multicriteria+Location+of+Thermal+Power+Plants&rft.au=Barda%2C+O+Haluk%3BDupuis%2C+Joseph%3BLencioni%2C+Pierre&rft.aulast=Barda&rft.aufirst=O&rft.date=1990-04-13&rft.volume=45&rft.issue=2%2C3&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Operational+Research&rft.issn=03772217&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Electricite de France N1 - Copyright - Copyright Elsevier Sequoia S.A. Apr 13, 1990 N1 - Last updated - 2014-05-20 N1 - CODEN - EJORDT N1 - SubjectsTermNotLitGenreText - North Africa; France ER - TY - JOUR T1 - Factors affecting the Heubach and MRI dustiness tests. AN - 79729348; 2327331 AB - The effect of test parameters upon material dustiness measured by the Heubach dust measurement appliance and the MRI dustiness tester was studied. The users of these tests can alter test parameters such as flow rate, sampling time, mass of material tested, bulk density, and vibrator setting. The effect of these parameters upon the aerosol produced in the dustiness tester was experimentally studied. All of the parameters affected in a complicated manner, the amount of dust and the size distribution of the dust generated during these tests. Therefore, dustiness test results should not be adjusted for variations in test parameters. The users of dustiness tests need to carefully control dustiness test parameters in order to have reproducible dustiness tests. JF - American Industrial Hygiene Association journal AU - Heitbrink, W A AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 210 EP - 216 VL - 51 IS - 4 SN - 0002-8894, 0002-8894 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Dust KW - Index Medicus KW - Aerosols -- analysis KW - Vibration KW - Environmental Monitoring -- instrumentation KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Materials Testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79729348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Factors+affecting+the+Heubach+and+MRI+dustiness+tests.&rft.au=Heitbrink%2C+W+A&rft.aulast=Heitbrink&rft.aufirst=W&rft.date=1990-04-01&rft.volume=51&rft.issue=4&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-24 N1 - Date created - 1990-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ultraviolet radiation exposures in a mycobacteriology laboratory. AN - 79710528; 2108936 JF - Health physics AU - Murray, W E AD - U.S. Department of Health and Human Services, Centers for Disease Control, Cincinnati, OH. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 507 EP - 510 VL - 58 IS - 4 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Humans KW - Environmental Exposure KW - Ultraviolet Rays KW - Laboratories KW - Sterilization -- instrumentation KW - Disinfection -- instrumentation KW - Mycobacterium tuberculosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79710528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Ultraviolet+radiation+exposures+in+a+mycobacteriology+laboratory.&rft.au=Murray%2C+W+E&rft.aulast=Murray&rft.aufirst=W&rft.date=1990-04-01&rft.volume=58&rft.issue=4&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-18 N1 - Date created - 1990-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detection and characterization of carcinogen-DNA adducts in exfoliated urothelial cells from 4-aminobiphenyl-treated dogs by 32P-postlabelling and subsequent thin-layer and high-pressure liquid chromatography. AN - 79709811; 2323002 AB - The recent development of sensitive methods to detect carcinogen-DNA adducts offers a useful biochemical approach to human risk assessment. However, a major obstacle to developing a human biomonitoring method for carcinogen-DNA adducts has been the problem of obtaining target tissue DNA samples by non-invasive means. This work describes a method for the isolation of nanogram quantities of DNA from urothelial cells exfoliated into urine and the detection of carcinogen-DNA adducts from that DNA by 32P-postlabelling methods. Urine samples were collected on ice from dogs treated with 4-aminobiphenyl (ABP) over a 2-week period and pooled according to an experimental plan that involved analysis of cumulative 48- or 72-h samples. The pooled samples were sieved and then washed repeatedly with a sucrose buffer to dissolve contaminating triple phosphate (MgNH4PO4), calcium oxalate and uric acid crystals. DNA was isolated using an enzyme-solvent extraction method with the DNA being co-precipitated from ethanol with glycogen. The DNA was hydrolysed and postlabelled with 32P under conditions of excess ATP so that nucleotides were labelled quantitatively. Adducts observed on the resulting thin-layer chromatograms were identical to those obtained from DNA modified in vitro with N-hydroxy-4-aminobiphenyl and from dog bladder urothelial DNA isolated from the ABP-dosed animals at termination of the experiment. Furthermore, a dose-related increase in ABP-DNA adduct formation was demonstrated. Thus, it appears that the carcinogen-DNA adduct levels in the exfoliated bladder cells are reflective of the levels in the intact urothelium once steady-state levels have been achieved. To establish the identity of the major ABP-urothelial DNA adduct in chronically-treated dogs, the predominant 32P-postlabelled adduct was eluted from the thin-layer chromatograms and co-injected on an HPLC system with a synthetic [3H]N-(deoxyguanosin-8-yl)-4-aminobiphenyl-3',5'-bisphosphate standard. Dual-label analysis of 3H and 32P indicated that both eluted from the column in the same fraction, which coincided with the UV absorbance peak of the synthetic marker. Preliminary experiments with exfoliated urothelial cells from human urines indicate that these methods should have general utility for monitoring humans exposed to urinary bladder carcinogens and for investigations of the biochemical mechanisms by which such adducts are formed in the urothelium. JF - Carcinogenesis AU - Talaska, G AU - Dooley, K L AU - Kadlubar, F F AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 639 EP - 646 VL - 11 IS - 4 SN - 0143-3334, 0143-3334 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - Deoxyguanine Nucleotides KW - 4-biphenylamine KW - 16054949HJ KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Deoxyguanine Nucleotides -- metabolism KW - Humans KW - Dogs KW - Chromatography, Thin Layer KW - Time Factors KW - Female KW - Epithelium -- drug effects KW - Chromatography, High Pressure Liquid KW - DNA -- isolation & purification KW - Carcinogens -- metabolism KW - Aminobiphenyl Compounds -- toxicity KW - DNA Damage KW - DNA -- metabolism KW - Urinary Bladder -- cytology KW - Urinary Bladder -- analysis KW - Aminobiphenyl Compounds -- metabolism KW - Urinary Bladder -- drug effects KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79709811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Detection+and+characterization+of+carcinogen-DNA+adducts+in+exfoliated+urothelial+cells+from+4-aminobiphenyl-treated+dogs+by+32P-postlabelling+and+subsequent+thin-layer+and+high-pressure+liquid+chromatography.&rft.au=Talaska%2C+G%3BDooley%2C+K+L%3BKadlubar%2C+F+F&rft.aulast=Talaska&rft.aufirst=G&rft.date=1990-04-01&rft.volume=11&rft.issue=4&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-21 N1 - Date created - 1990-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cloning and expression of functional fragment C of tetanus toxin. AN - 79692465; 2318526 AB - A segment of Clostridium tetani DNA corresponding to fragment C of tetanus toxin was amplified by using the polymerase chain reaction. This fragment was cloned into expression vector pTTQ8, under the control of the tac promoter. Expression of this plasmid in Escherichia coli resulted in the production of a protein consisting of 8 amino acids of the vector fused to the C-terminal 460 amino acids of tetanus toxin. This protein (rFragment C) was recognized by an antipeptide antibody specific for fragment C in an enzyme-linked immunosorbent assay and on immunoblots. rFragment C could be purified significantly in one step by immunoaffinity chromatography. Immunization of mice with rFragment C resulted in the production of antibodies that were able to protect the mice against a challenge with tetanus toxin. rFragment C bound to ganglioside GT1b and to neuronal cells in a manner indistinguishable from that of fragment C obtained by papain cleavage of tetanus toxin. For many applications, rFragment C appears to be a suitable alternative to tetanus toxin or toxin-derived fragment C. JF - Infection and immunity AU - Halpern, J L AU - Habig, W H AU - Neale, E A AU - Stibitz, S AD - Division of Bacterial Products, Food and Drug Administration, Bethesda, Maryland. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 1004 EP - 1009 VL - 58 IS - 4 SN - 0019-9567, 0019-9567 KW - Gangliosides KW - 0 KW - Peptide Fragments KW - Tetanus Toxin KW - Index Medicus KW - Chromatography, Affinity KW - Polymerase Chain Reaction KW - Animals KW - Neurons -- metabolism KW - Mice KW - Gangliosides -- metabolism KW - Tetanus Toxin -- immunology KW - Peptide Fragments -- biosynthesis KW - Peptide Fragments -- genetics KW - Tetanus Toxin -- biosynthesis KW - Tetanus Toxin -- genetics KW - Cloning, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79692465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Cloning+and+expression+of+functional+fragment+C+of+tetanus+toxin.&rft.au=Halpern%2C+J+L%3BHabig%2C+W+H%3BNeale%2C+E+A%3BStibitz%2C+S&rft.aulast=Halpern&rft.aufirst=J&rft.date=1990-04-01&rft.volume=58&rft.issue=4&rft.spage=1004&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-03 N1 - Date created - 1990-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1984 May 25;224(4651):881-4 [6326263] Infect Immun. 1983 Dec;42(3):942-8 [6642671] Curr Top Microbiol Immunol. 1986;129:93-179 [3533452] Nucleic Acids Res. 1986 Oct 10;14(19):7809-12 [3774547] EMBO J. 1986 Oct;5(10):2495-502 [3536478] Nature. 1986 Nov 6-12;324(6092):76-8 [3785374] Gene. 1987;51(2-3):255-67 [3110013] Infect Immun. 1987 Nov;55(11):2541-5 [3312002] Int J Pept Protein Res. 1987 Dec;30(6):794-800 [3440702] Naunyn Schmiedebergs Arch Pharmacol. 1988 Aug;338(2):99-106 [3054567] Infect Immun. 1989 Jan;57(1):18-22 [2909486] J Neurochem. 1989 Jul;53(1):155-61 [2656915] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] J Gen Microbiol. 1959 Apr;20(2):291-300 [13654724] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Biochem J. 1973 Jul;133(3):529-39 [4733239] Biochem Biophys Res Commun. 1974 Apr 23;57(4):1257-62 [4208570] J Biol Chem. 1977 Jan 10;252(1):187-93 [401808] J Neurochem. 1977 Mar;28(3):529-42 [67185] J Neurophysiol. 1977 Sep;40(5):1132-50 [333062] Brain Res. 1978 Jun 9;148(1):251-9 [350352] Immunochemistry. 1978 Jul;15(7):429-36 [30693] J Biol Chem. 1979 May 25;254(10):3826-32 [220221] J Biol Chem. 1979 Nov 10;254(21):10728-33 [40973] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 [388439] J Biol Chem. 1980 Jul 10;255(13):6071-6 [7391005] J Neurosci. 1983 Nov;3(11):2310-23 [6631482] J Bacteriol. 1986 Jan;165(1):21-7 [3510187] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Foodborne Snow Mountain agent gastroenteritis with secondary person-to-person spread in a retirement community. AN - 79678907; 2107737 AB - A variety of small round-structured viruses are being recognized with increasing frequency as a cause of gastroenteritis in the community, but have rarely been reported to cause outbreaks in hospitals or extended-care facilities. From March 20 through April 15, 1988, an outbreak of gastroenteritis occurred in a retirement facility in the San Francisco Bay area. Illness was characterized by diarrhea, nausea, and vomiting; two residents died. Attack rates were 46% (155 of 336) in residents and 37% (28 of 75) in employees. During the initial outbreak period, illness among residents was associated with two shrimp meals served in the facility dining hall (odds ratio = 6.7). Person-to-person transmission probably occurred: The risk of becoming ill one or two days after a roommate became ill was significantly greater than that of becoming ill at other times during the outbreak (risk ratio = 6.5). Microbiologic examinations for bacterial and parasitic enteric pathogens were negative; however, 27-nm viral particles were detected by immune electron microscopy and by blocking enzyme immunoassay to Snow Mountain agent in stools obtained at the onset of illness from one of six ill residents. Seroconversion (greater than fourfold antibody rise) to Snow Mountain agent was detected in acute- and convalescent-phase serum specimens from five of six ill residents as measured by enzyme immunoassay, but not for Norwalk agent as measured by radioimmunoassay. This report of an outbreak of Snow Mountain agent gastroenteritis in an extended-care facility documents that these difficult-to-identify 27-nm viruses can cause outbreaks in inpatient settings. JF - American journal of epidemiology AU - Gordon, S M AU - Oshiro, L S AU - Jarvis, W R AU - Donenfeld, D AU - Ho, M S AU - Taylor, F AU - Greenberg, H B AU - Glass, R AU - Madore, H P AU - Dolin, R AD - Hospital Infections Program, Centers for Disease Control, US Public Health Service, Atlanta, GA. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 702 EP - 710 VL - 131 IS - 4 SN - 0002-9262, 0002-9262 KW - Antibodies, Viral KW - 0 KW - Index Medicus KW - Skilled Nursing Facilities KW - Feces -- microbiology KW - Viruses, Unclassified -- isolation & purification KW - Humans KW - Surveys and Questionnaires KW - Case-Control Studies KW - Aged KW - Occupational Diseases -- epidemiology KW - Viruses, Unclassified -- immunology KW - California -- epidemiology KW - Male KW - Female KW - Antibodies, Viral -- analysis KW - Gastroenteritis -- etiology KW - Food Microbiology KW - Virus Diseases -- transmission KW - Disease Outbreaks KW - Homes for the Aged -- manpower KW - Gastroenteritis -- epidemiology KW - Virus Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79678907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Foodborne+Snow+Mountain+agent+gastroenteritis+with+secondary+person-to-person+spread+in+a+retirement+community.&rft.au=Gordon%2C+S+M%3BOshiro%2C+L+S%3BJarvis%2C+W+R%3BDonenfeld%2C+D%3BHo%2C+M+S%3BTaylor%2C+F%3BGreenberg%2C+H+B%3BGlass%2C+R%3BMadore%2C+H+P%3BDolin%2C+R&rft.aulast=Gordon&rft.aufirst=S&rft.date=1990-04-01&rft.volume=131&rft.issue=4&rft.spage=702&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-25 N1 - Date created - 1990-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Rural health care: the future of the hospital T2 - AHCPR program note Rept. no. NCHSR 90-6 OM90-0055 AN - 59543572; 1991-0201083 AB - Examines the delivery system and federal, state, and private programs that have affected the way in which care is provided. JF - Nat Tech Info Service, Spring 1990. 33-73 pp. AU - Ermann, Dan A Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 41 EP - 73 PB - Nat Tech Info Service KW - Medical service, Rural -- United States KW - Hospitals -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59543572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Ermann%2C+Dan+A&rft.aulast=Ermann&rft.aufirst=Dan&rft.date=1990-04-01&rft.volume=&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=Rural+health+care%3A+the+future+of+the+hospital&rft.title=Rural+health+care%3A+the+future+of+the+hospital&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Nat Tech Info Service $15 N1 - Document feature - bibl(s), table(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Metabolism of the arylamide herbicide propanil. II. Effects of propanil and its derivatives on hepatic microsomal drug-metabolizing enzymes in the rat. AN - 79681240; 2315923 AB - Propanil (3,4-dichloropropionanilide) is an arylamide herbicide that has been reported to be contaminated with the cytochrome P450 enzyme inducers 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB), which are structural analogs of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We determined if treatment of rats with TCAB, TCAOB, propanil, 3,4-dichloroaniline, TCDD, or phenobarbital induced the hepatic microsomal metabolism of propanil and 3,4-dichloroaniline. Acylamidase-catalyzed hydrolysis of propanil to 3,4-dichloroaniline was not induced by any of the pretreatments; however, hydroxylation of propanil at the 2'-position was induced by TCDD, TCAB, TCAOB, propanil, and 3,4-dichloroaniline pretreatments. Ring- and N-hydroxylations of 3,4-dichloroaniline were induced by TCDD, TCAB, TCAOB, and 3,4-dichloroaniline pretreatments. Microsomal 7-ethoxyresorufin-O-deethylase (EROD) and 7-benzoxyresorufin-O-dealkylase (BROD) activities and electrophoretic mobility of microsomal proteins suggested that cytochromes P450c and P450d were induced by TCAB and TCAOB pretreatment. EROD, BROD, and 7-pentoxyresorufin-O-dealkylase activities were slightly increased in microsomes from propanil- and 3,4-dichloroaniline-pretreated rats, which suggests that these compounds may be weak inducers of cytochrome P450 isozymes. JF - Toxicology and applied pharmacology AU - McMillan, D C AU - Leakey, J E AU - Arlotto, M P AU - McMillan, J M AU - Hinson, J A AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990/03/15/ PY - 1990 DA - 1990 Mar 15 SP - 102 EP - 112 VL - 103 IS - 1 SN - 0041-008X, 0041-008X KW - Anilides KW - 0 KW - Aniline Compounds KW - Azo Compounds KW - Chlorobenzenes KW - Polychlorinated Dibenzodioxins KW - 3,4,3',4'-tetrachloroazobenzene KW - 14047-09-7 KW - 3,4-dichloroaniline KW - 20KR9WJ4NS KW - 3,4,3',4'-tetrachloroazoxybenzene KW - 21232-47-3 KW - Propanil KW - 709-98-8 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Polychlorinated Dibenzodioxins -- pharmacology KW - Azo Compounds -- pharmacology KW - Chlorobenzenes -- pharmacology KW - Male KW - Aniline Compounds -- metabolism KW - Enzyme Induction -- drug effects KW - Microsomes, Liver -- enzymology KW - Propanil -- metabolism KW - Microsomes, Liver -- drug effects KW - Anilides -- toxicity KW - Propanil -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79681240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Metabolism+of+the+arylamide+herbicide+propanil.+II.+Effects+of+propanil+and+its+derivatives+on+hepatic+microsomal+drug-metabolizing+enzymes+in+the+rat.&rft.au=McMillan%2C+D+C%3BLeakey%2C+J+E%3BArlotto%2C+M+P%3BMcMillan%2C+J+M%3BHinson%2C+J+A&rft.aulast=McMillan&rft.aufirst=D&rft.date=1990-03-15&rft.volume=103&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-23 N1 - Date created - 1990-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of the arylamide herbicide propanil. I. Microsomal metabolism and in vitro methemoglobinemia. AN - 79678257; 2315934 AB - Methemoglobinemia produced by exposure to the herbicide propanil (3,4-dichloropropionanilide) is thought to be mediated by toxic metabolites formed during the hepatic clearance of the parent compound. We examined the metabolism of propanil and 3,4-dichloroaniline in rat liver microsomes to identify metabolites that may be involved in propanil-induced methemoglobinemia. The major pathway of propanil metabolism in microsomal incubations was acylamidase-catalyzed hydrolysis to 3,4-dichloroaniline. The reaction did not require NADPH, and was inhibited by the acylamidase inhibitors paraoxon and sodium fluoride. Oxidized metabolites were isolated by high-performance liquid chromatography, and identified as 2'-hydroxypropanil and 6-hydroxypropanil by comparison of their mass and nuclear magnetic resonance spectra to those of synthetic standards. Major microsomal metabolites of 3,4-dichloroaniline were 6-hydroxy-3,4-dichloroaniline and N-hydroxy-3,4-dichloroaniline. Both N-hydroxy-3,4-dichloroaniline and 6-hydroxy-3,4-dichloroaniline directly oxidized hemoglobin in rat erythrocyte suspensions in a concentration-dependent manner; however, the potency of N-hydroxy-3,4-dichloroaniline was at least an order of magnitude greater than that of 6-hydroxy-3,4-dichloroaniline. JF - Toxicology and applied pharmacology AU - McMillan, D C AU - Freeman, J P AU - Hinson, J A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990/03/15/ PY - 1990 DA - 1990 Mar 15 SP - 90 EP - 101 VL - 103 IS - 1 SN - 0041-008X, 0041-008X KW - Anilides KW - 0 KW - Propanil KW - 709-98-8 KW - Methemoglobin KW - 9008-37-1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Mass Spectrometry KW - Animals KW - Methemoglobin -- biosynthesis KW - Male KW - Chromatography, High Pressure Liquid KW - Microsomes, Liver -- metabolism KW - Propanil -- metabolism KW - Methemoglobinemia -- chemically induced KW - Anilides -- metabolism KW - Propanil -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79678257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Metabolism+of+the+arylamide+herbicide+propanil.+I.+Microsomal+metabolism+and+in+vitro+methemoglobinemia.&rft.au=McMillan%2C+D+C%3BFreeman%2C+J+P%3BHinson%2C+J+A&rft.aulast=McMillan&rft.aufirst=D&rft.date=1990-03-15&rft.volume=103&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-23 N1 - Date created - 1990-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of subsequent anticoagulants to increase the predictive value of Medicaid deep venous thromboembolism diagnoses. AN - 80274793; 2073498 AB - Linked data bases that derive their information from health care administrative sources are increasingly being used to conduct pharmacoepidemiologic research. Computerized case ascertainment using these data would be highly advantageous in terms of time and cost considerations. For a study of oral-contraceptive-associated deep venous thromboembolism, we evaluated the utility of using anticoagulant treatment codes to validate diagnostic codes suggestive of deep venous thrombosis and pulmonary embolism. By requiring evidence of outpatient anticoagulant use within six months of hospitalization, the predictive value of case ascertainment increased from 42% to 65% for "probable" deep venous thromboembolism and from 70% to 97% for "possible" deep venous thromboembolism. In addition, use of anticoagulant treatment codes as a second marker of disease resulted in nondifferential outcome misclassification when the study base was restricted to current oral-contraceptive users. Use of confirmatory treatment claims may provide a rapid, cost-effective alternative to medical-record-based case ascertainment for pharmacoepidemiologic studies of selected outcomes conducted in Medicaid and other linked universal health care coverage populations. JF - Epidemiology (Cambridge, Mass.) AU - Gerstman, B B AU - Freiman, J P AU - Hine, L K AD - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 122 EP - 127 VL - 1 IS - 2 SN - 1044-3983, 1044-3983 KW - Anticoagulants KW - 0 KW - Contraceptives, Oral KW - Index Medicus KW - Population KW - United States KW - Data Linkage KW - Measurement KW - Research Methodology KW - Epidemiologic Methods KW - Oral Contraceptives KW - Contraceptive Methods KW - Treatment KW - Developed Countries KW - Thromboembolism KW - Classification KW - Information Processing KW - Data Collection KW - Diseases KW - Family Planning KW - Data Analysis KW - Screening KW - North America KW - Americas KW - Reliability KW - Computers KW - Vascular Diseases KW - Information KW - Northern America KW - Contraception KW - Embolism KW - Examinations And Diagnoses KW - Contraceptives, Oral -- adverse effects KW - Probability KW - Contraceptives, Oral -- administration & dosage KW - Reproducibility of Results KW - Pharmacy Service, Hospital -- statistics & numerical data KW - Humans KW - Adult KW - Predictive Value of Tests KW - Adolescent KW - United States -- epidemiology KW - Female KW - Anticoagulants -- therapeutic use KW - Thrombophlebitis -- diagnosis KW - Pulmonary Embolism -- diagnosis KW - Databases, Factual KW - Pulmonary Embolism -- drug therapy KW - Medicaid KW - Thrombophlebitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80274793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Use+of+subsequent+anticoagulants+to+increase+the+predictive+value+of+Medicaid+deep+venous+thromboembolism+diagnoses.&rft.au=Gerstman%2C+B+B%3BFreiman%2C+J+P%3BHine%2C+L+K&rft.aulast=Gerstman&rft.aufirst=B&rft.date=1990-03-01&rft.volume=1&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-18 N1 - Date created - 1991-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epidemiology. 1990 Mar;1(2):98-100 [2073512] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detection and quantitation of ethylene oxide, 2-chloroethanol, and ethylene glycol with capillary gas chromatography. AN - 80214566; 2273068 AB - A procedure is described for detection and quantitation of ethylene oxide and two major reaction products. Detection of ethylene oxide residuals extracted from alcohol pads (cellulose) and plastic material is illustrated. Quantitation of the three compounds can be obtained with a single gas chromatographic (GC) analysis. A DB-Wax-30N, 0.25 mm i.d. column is used with 1:50 split injections with dimethylformamide as the solvent and 1:100 split injections with water as the solvent. A DB-Wax-30W, 0.32 mm i.d. column is used for on-column injections and 1:100 split water injections. Linearity of the three compounds is demonstrated. JF - Journal of chromatographic science AU - Danielson, J W AU - Snell, R P AU - Oxborrow, G S AD - Food and Drug Administration, Sterility Analysis Research Center, Minneapolis, Minnesota 55455. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 97 EP - 101 VL - 28 IS - 3 SN - 0021-9665, 0021-9665 KW - Ethylene Glycols KW - 0 KW - Dimethylformamide KW - 8696NH0Y2X KW - Ethylene Oxide KW - JJH7GNN18P KW - Vinyl Chloride KW - WD06X94M2D KW - Index Medicus KW - Vinyl Chloride -- analysis KW - Ethylene Oxide -- analysis KW - Ethylene Glycols -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80214566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Detection+and+quantitation+of+ethylene+oxide%2C+2-chloroethanol%2C+and+ethylene+glycol+with+capillary+gas+chromatography.&rft.au=Danielson%2C+J+W%3BSnell%2C+R+P%3BOxborrow%2C+G+S&rft.aulast=Danielson&rft.aufirst=J&rft.date=1990-03-01&rft.volume=28&rft.issue=3&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-27 N1 - Date created - 1991-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic toxicity/carcinogenicity studies of sulphamethazine in Fischer 344/N rats: two-generation exposure. AN - 79792618; 2344990 AB - Fischer 344 rats were given 10, 40, 600, 1200 or 2400 ppm sulphamethazine (SMZ) in the diet to determine the toxicity and potential carcinogenicity of SMZ. There were 225 rats of each sex in the control groups and 135 of each sex in each dose group. Animals were killed after 3, 12, 18 or 24 months of continuous dosing. Body weights, feed consumption, clinical observations, organ weights and histopathology data were collected. A slight decrease in body-weight gain was observed in the high-dose groups compared with the controls. No difference in feed consumption was found between the control and dosed rats. Mortality was inversely related to SMZ dose, especially in females, that is mortality was highest in the controls and decreased as the dose of SMZ increased. A statistically significant dose-related increase in the incidence of follicular cell adenocarcinomas of the thyroid gland was observed in the animals killed after 24 months. The incidences of non-neoplastic lesions of the thyroid gland in treated animals were significantly higher among treated animals than among controls; these lesions included follicular cell hyperplasia, follicular cell focal cellular change and multilocular cysts. The incidences of retinal atrophy, atrophy of the acinar pancreas (males), and dilatation of the uterine lumen also increased with increasing SMZ dose. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Littlefield, N A AU - Sheldon, W G AU - Allen, R AU - Gaylor, D W AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 157 EP - 167 VL - 28 IS - 3 SN - 0278-6915, 0278-6915 KW - Carcinogens KW - 0 KW - Sulfamethazine KW - 48U51W007F KW - Index Medicus KW - Animals KW - Adenocarcinoma -- chemically induced KW - Thyroid Gland -- pathology KW - Dose-Response Relationship, Drug KW - Rats KW - Rats, Inbred F344 KW - Hyperplasia KW - Thyroid Gland -- drug effects KW - Uterine Diseases -- chemically induced KW - Adenoma -- chemically induced KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Female KW - Male KW - Pancreatic Diseases -- chemically induced KW - Retinal Degeneration -- chemically induced KW - Organ Size -- drug effects KW - Thyroid Neoplasms -- chemically induced KW - Sulfamethazine -- toxicity KW - Carcinogens -- toxicity KW - Thyroid Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79792618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Chronic+toxicity%2Fcarcinogenicity+studies+of+sulphamethazine+in+Fischer+344%2FN+rats%3A+two-generation+exposure.&rft.au=Littlefield%2C+N+A%3BSheldon%2C+W+G%3BAllen%2C+R%3BGaylor%2C+D+W&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1990-03-01&rft.volume=28&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-02 N1 - Date created - 1990-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells. AN - 79784563; 2188067 AB - 1-Nitropyrene, a tumorigenic environmental pollutant, is mutagenic in Chinese hamster ovary (CHO) cells in the presence of a liver homogenate 9000 g supernatant fraction (S9). The metabolic pathways involved in this response were studied by comparing the mutagenicities at the hypoxanthine-guanine phosphoribosyl transferase locus of 1-nitropyrene, some oxidized microsomal metabolites of 1-nitropyrene, and related compounds. In the absence of S9, pyrene 4,5-oxide and 6-hydroxy-1-nitropyrene displayed the highest mutagenicities, followed by 1-nitropyrene 9,10-oxide and 1-nitropyrene 4,5-oxide; 3- and 8-hydroxy-1-nitropyrene were weaker mutagens, while pyrene and 1-nitropyrene were essentially without activity. With S9, the order of mutagenic potency was 1-nitropyrene 4,5-oxide greater than 6-hydroxy-1-nitropyrene approximately 1-nitropyrene 9,10-oxide greater than 1-nitropyrene approximately 3-hydroxy-1-nitropyrene approximately 8-hydroxy-1-nitropyrene greater than pyrene approximately pyrene 4,5-oxide, with the latter two compounds being essentially inactive. Inclusion of the epoxide hydrolase inhibitor 1,2-epoxy-3,3,3-trichloropropane during the S9-mediated treatment of CHO cells with 1-nitropyrene increased mutation induction 5-fold. Also, liver microsomes prepared from guinea-pigs treated with Aroclor 1254 mediated a stronger mutagenic response with 1-nitropyrene than microsomes from Aroclor-treated rats. 1-Nitropyrene was essentially non-mutagenic in the presence of microsomes from untreated and phenobarbital-treated rats. Examination of the 1-nitropyrene metabolites produced during the microsomal incubations indicated that Aroclor-induced guinea-pig microsomes yielded substantial amounts of 1-nitropyrene 4,5-dihydrodiol, while Aroclor-induced rat microsomes produced 6-fold more 6- and 8-hydroxy-1-nitropyrene than phenobarbital microsomes.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Mutagenesis AU - Heflich, R H AU - Thornton-Manning, J R AU - Kinouchi, T AU - Beland, F A AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 151 EP - 157 VL - 5 IS - 2 SN - 0267-8357, 0267-8357 KW - Liver Extracts KW - 0 KW - Mutagens KW - Pyrenes KW - 1-nitropyrene KW - TD1665I8Q4 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Mutagenicity Tests KW - Liver Extracts -- metabolism KW - Female KW - Cricetinae KW - Pyrenes -- toxicity KW - Microsomes, Liver -- metabolism KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79784563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Mutagenicity+of+oxidized+microsomal+metabolites+of+1-nitropyrene+in+Chinese+hamster+ovary+cells.&rft.au=Heflich%2C+R+H%3BThornton-Manning%2C+J+R%3BKinouchi%2C+T%3BBeland%2C+F+A&rft.aulast=Heflich&rft.aufirst=R&rft.date=1990-03-01&rft.volume=5&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-28 N1 - Date created - 1990-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of three sampling and analytical methods for measuring m-xylene in expired air of exposed humans. AN - 79725852; 2327325 AB - Three breath sampling and analytical methods were tested following exposure of 12 subjects for 4 hr to 75 ppm m-xylene in a controlled environmental chamber. Mixed-expired breath was sampled for m-xylene from all 12 subjects with a new stainless steel device that permits continuous mainstream or sidestream sampling of the solvents present. The m-xylene was sampled from the mainstream using charcoal cloth and from the sidestream using Tenax TA. Alveolar breath also was sampled for m-xylene from 6 of these subjects using bags. The carbon dioxide concentrations of the mixed and alveolar samples, obtained from these 6 subjects, were also determined and used to assess the accuracy of the mixed-expired sampling and analytical procedures. Breath sampling was conducted over the immediate 240-min postexposure period. All m-xylene samples were analyzed using gas chromatography with flame ionization detection. Carbon dioxide concentrations were determined with an infrared analyzer. Nonlinear regression analysis was used to model the desaturation of m-xylene via the breath. Overall, the desaturation of m-xylene from all subjects by all methods was best described using three-compartment pharmacokinetic models. The precision of each sampling and analytical method, estimated from the residual variabilities of the desaturation curves were 0.13 for alveolar sampling, 0.14 for mainstream-mixed sampling (12 subjects), and 0.23 for sidestream-mixed sampling (12 subjects). For all 12 subjects, the breath m-xylene concentrations determined by sidestream-mixed sampling averaged 83% of those determined by mainstream-mixed sampling; this bias was significant. For the 6 subjects from whom both mixed-expired and alveolar breath samples were obtained, the average m-xylene desaturation rates determined by both mainstream-mixed and alveolar sampling were comparable but substantially different from those determined by sidestream-mixed sampling. For these subjects, comparison of the average and individual mixed to alveolar ratios of m-xylene and carbon dioxide showed that mainstream-mixed sampling was accurate and that sidestream-mixed sampling was not. JF - American Industrial Hygiene Association journal AU - Glaser, R A AU - Arnold, J E AU - Shulman, S A AD - National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 139 EP - 150 VL - 51 IS - 3 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Xylenes KW - 3-xylene KW - O9XS864HTE KW - Index Medicus KW - Humans KW - Environmental Exposure KW - Air Pollutants, Occupational -- analysis KW - Breath Tests -- instrumentation KW - Xylenes -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79725852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Comparison+of+three+sampling+and+analytical+methods+for+measuring+m-xylene+in+expired+air+of+exposed+humans.&rft.au=Glaser%2C+R+A%3BArnold%2C+J+E%3BShulman%2C+S+A&rft.aulast=Glaser&rft.aufirst=R&rft.date=1990-03-01&rft.volume=51&rft.issue=3&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-14 N1 - Date created - 1990-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypoglycin A content in the aril, seeds, and husks of ackee fruit at various stages of ripeness. AN - 79712508; 2324040 AB - Recently, hypoglycin A (HG-A), a natural toxin, was detected in canned ackee fruit. To determine the source of contamination, the HG-A content in the ackee fruit components (aril, seeds, and husks) at various stages of ripeness was determined by a method using an amino acid analyzer. HG-A concentrations in the unripe ackee fruit components were 939, 711, and 41.6 mg/100 g of seed, aril, and husk components, respectively. Analysis of the ripe fruit components showed that HG-A in the seed decreased to 269 mg/100 g and remained unchanged in the husk while the concentrations in the edible ripe aril decreased below the detection limit of 1.2 mg/100 g. JF - Journal - Association of Official Analytical Chemists AU - Chase, G W AU - Landen, W O AU - Soliman, A G AD - Food and Drug Administration, Atlanta Center for Nutrient Analysis, GA 30309. PY - 1990 SP - 318 EP - 319 VL - 73 IS - 2 SN - 0004-5756, 0004-5756 KW - Amino Acids KW - 0 KW - Cyclopropanes KW - Hypoglycins KW - hypoglycin KW - 156-56-9 KW - Index Medicus KW - Amino Acids -- analysis KW - Hypoglycins -- analysis KW - Cyclopropanes -- analysis KW - Fruit -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79712508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Hypoglycin+A+content+in+the+aril%2C+seeds%2C+and+husks+of+ackee+fruit+at+various+stages+of+ripeness.&rft.au=Chase%2C+G+W%3BLanden%2C+W+O%3BSoliman%2C+A+G&rft.aulast=Chase&rft.aufirst=G&rft.date=1990-03-01&rft.volume=73&rft.issue=2&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-18 N1 - Date created - 1990-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outgrowth of naturally occurring Clostridium botulinum in vacuum-packaged fresh fish. AN - 79710793; 2182605 AB - A total of 1074 test samples of commercial, domestic, vacuum-packaged fresh fish were studied to determine whether spoilage occurs before the products become toxic from naturally occurring Clostridium botulinum spores. The products were incubated for 12 days at 12 degrees C (mild abuse). After incubation, they were tested for botulinal toxin and evaluated for organoleptic acceptability. Even when only marginally acceptable to laboratory personnel, none of the 1074 test samples were positive for C. botulinum toxin. Thus, the fish either contained no C. botulinum spores, or the spores were unable to grow out and produce toxin before spoilage made the product marginally unacceptable. JF - Journal - Association of Official Analytical Chemists AU - Lilly, T AU - Kautter, D A AD - Food and Drug Administration, Division of Microbiology, Washington, DC 20204. PY - 1990 SP - 211 EP - 212 VL - 73 IS - 2 SN - 0004-5756, 0004-5756 KW - Index Medicus KW - Animals KW - Food Handling KW - Fishes -- microbiology KW - Food Microbiology KW - Clostridium botulinum -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79710793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Outgrowth+of+naturally+occurring+Clostridium+botulinum+in+vacuum-packaged+fresh+fish.&rft.au=Lilly%2C+T%3BKautter%2C+D+A&rft.aulast=Lilly&rft.aufirst=T&rft.date=1990-03-01&rft.volume=73&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-18 N1 - Date created - 1990-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Liquid chromatographic method for determination of aflatoxins B1, B2, G1, and G2 in corn and peanut products: collaborative study. AN - 79710423; 2157698 AB - A collaborative study of a liquid chromatographic method for the determination of aflatoxins B1, B2, G1, and G2 was conducted in laboratories located in the United States, Canada, South Africa, and Switzerland. Twenty-one artificially contaminated raw peanuts, peanut butter, and corn samples containing varying amounts of aflatoxins B1, B2, G1, and G2 were distributed to participating laboratories. The test portion was extracted with methanol-0.1N HCl (4 + 1), filtered, defatted with hexane, and then partitioned with methylene chloride. The concentrated extract was passed through a silica gel column. Aflatoxins B1 and G1 were derivatized with trifluoroacetic acid, and the individual aflatoxins were determined by reverse-phase liquid chromatography with fluorescence detection. Statistical analysis of the data was performed to determine or confirm outliers, and to compute repeatability and reproducibility of the method. For corn, relative standard deviations for repeatability (RSDr) for aflatoxin B1 ranged from 27.2 to 8.3% for contamination levels from 5 through 50 ng/g. For raw peanuts and peanut butter, RSDr values for aflatoxin B1 were 35.0 to 41.2% and 11.2 to 19.1%, respectively, for contamination levels from 5 through 25 ng/g. RSDr values for aflatoxins B2, G1, and G2 were similar. Relative standard deviations for reproducibility (RSDr) for aflatoxin B1 ranged from 15.8 to 38.4%, 24.4 to 33.4%, and 43.9 to 54.0% for corn, peanut butter, and raw peanuts, respectively. The method has been adopted official first action for the determination of aflatoxins B1, B2, G1, and G2 in peanut butter and corn at concentrations greater than or equal to 13 ng total aflatoxins/g. JF - Journal - Association of Official Analytical Chemists AU - Park, D L AU - Nesheim, S AU - Trucksess, M W AU - Stack, M E AU - Newell, R F AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1990 SP - 260 EP - 266 VL - 73 IS - 2 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Indicators and Reagents KW - aflatoxin G1 KW - 1DB78J7PUD KW - aflatoxin G2 KW - 2MS0D8WA29 KW - Silica Gel KW - 60650-90-0 KW - Silicon Dioxide KW - 7631-86-9 KW - aflatoxin B2 KW - 7SKR7S646P KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - United States KW - Canada KW - Chromatography, Liquid KW - South Africa KW - Switzerland KW - Aflatoxins -- analysis KW - Food Microbiology KW - Arachis -- analysis KW - Zea mays -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79710423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Liquid+chromatographic+method+for+determination+of+aflatoxins+B1%2C+B2%2C+G1%2C+and+G2+in+corn+and+peanut+products%3A+collaborative+study.&rft.au=Park%2C+D+L%3BNesheim%2C+S%3BTrucksess%2C+M+W%3BStack%2C+M+E%3BNewell%2C+R+F&rft.aulast=Park&rft.aufirst=D&rft.date=1990-03-01&rft.volume=73&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-18 N1 - Date created - 1990-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of food consumption factors in establishing drug tolerances. AN - 79695673; 2180883 AB - The Center for Veterinary Medicine's food consumption policy was adopted in 1978 before suitable data were available on the consumption of organ meats. Consumption is expressed in terms of amounts expected to be consumed daily by an adult human. Before the Center for Veterinary Medicine (Center) can choose a suitable database to develop a new guideline, the Center must resolve a number of difficult policy choices. After the policy issues are resolved, the Center could use the 1977-78 USDA National Food Consumption survey or an approach based on carcass yield to develop the new guideline. JF - Journal of animal science AU - Benson, R AD - Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 874 EP - 879 VL - 68 IS - 3 SN - 0021-8812, 0021-8812 KW - Index Medicus KW - Meat KW - Information Systems KW - Animals KW - Humans KW - Eating KW - Food Contamination KW - Drug Residues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79695673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+animal+science&rft.atitle=The+role+of+food+consumption+factors+in+establishing+drug+tolerances.&rft.au=Benson%2C+R&rft.aulast=Benson&rft.aufirst=R&rft.date=1990-03-01&rft.volume=68&rft.issue=3&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=Journal+of+animal+science&rft.issn=00218812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-01 N1 - Date created - 1990-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Environmentally related disorders of the nervous system. AN - 79693718; 2157116 AB - Specific physical and chemical agents found in the workplace and in the general environment are responsible for characteristic pathologic processes within the nervous system. It has been shown that many neurotoxic agents produce a dose-related spectrum of impairment ranging from mild slowing of nerve conducting velocity or prolongation in reaction time to neuropathy and frank encephalopathy. Clinical manifestations are determined by the agent involved, by the dose of exposure, the vulnerability of the cellular target, the ability of the organism to metabolize and excrete the agent, and the ability to repair damage. An occupational history, including evaluation of evidence of specific agents and job history, is a critical component in the clinical management of individuals with suspect neurotoxic disease. Environmentally-induced disorders can be prevented by appropriate environmental controls. Prevention of neurotoxic disease is a complex process requiring continuous involvement of public health agencies and strong scientific research. JF - The Medical clinics of North America AU - Baker, E L AU - Feldman, R G AU - French, J G AD - NIOSH, Centers for Disease Control, Atlanta, Georgia. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 325 EP - 345 VL - 74 IS - 2 SN - 0025-7125, 0025-7125 KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Diseases -- diagnosis KW - Central Nervous System Diseases -- chemically induced KW - Peripheral Nervous System Diseases -- etiology KW - Stress, Mechanical KW - Humans KW - Environmental Exposure KW - Peripheral Nervous System Diseases -- chemically induced KW - Occupational Diseases -- chemically induced KW - Peripheral Nervous System Diseases -- diagnosis KW - Central Nervous System Diseases -- diagnosis KW - Nervous System Diseases -- etiology KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79693718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Medical+clinics+of+North+America&rft.atitle=Environmentally+related+disorders+of+the+nervous+system.&rft.au=Baker%2C+E+L%3BFeldman%2C+R+G%3BFrench%2C+J+G&rft.aulast=Baker&rft.aufirst=E&rft.date=1990-03-01&rft.volume=74&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=The+Medical+clinics+of+North+America&rft.issn=00257125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-02 N1 - Date created - 1990-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monoclonal antibody to type F Clostridium botulinum toxin. AN - 79690974; 2180373 AB - Hybridomas synthesizing monoclonal antibodies (MAbs) against type F Clostridium botulinum toxin were developed. MAb from one stable hybridoma, hybridoma 223, consisted of kappa light chains and an immunoglobulin G subclass 2a heavy chain. This MAb was used in a double-sandwich enzyme-linked immunosorbent assay to detect type F toxin in foods, culture fluids, and purified toxin preparations. The sensitivity of the double-sandwich enzyme-linked immunosorbent assay was approximately 10 mouse lethal doses of toxin per ml of toxic fluid. JF - Applied and environmental microbiology AU - Ferreira, J L AU - Hamdy, M K AU - McCay, S G AU - Zapatka, F A AD - Food and Drug Administration, Atlanta, Georgia 30309. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 808 EP - 811 VL - 56 IS - 3 SN - 0099-2240, 0099-2240 KW - Antibodies, Bacterial KW - 0 KW - Antibodies, Monoclonal KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Animals KW - Food Contamination -- analysis KW - Hybridomas -- immunology KW - Enzyme-Linked Immunosorbent Assay KW - Clostridium botulinum -- immunology KW - Mice KW - Botulinum Toxins -- immunology KW - Botulinum Toxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79690974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Monoclonal+antibody+to+type+F+Clostridium+botulinum+toxin.&rft.au=Ferreira%2C+J+L%3BHamdy%2C+M+K%3BMcCay%2C+S+G%3BZapatka%2C+F+A&rft.aulast=Ferreira&rft.aufirst=J&rft.date=1990-03-01&rft.volume=56&rft.issue=3&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Microbiol. 1968 Jan;16(1):21-4 [4965915] Appl Microbiol. 1973 Apr;25(4):545-9 [4633477] Appl Microbiol. 1975 May;29(5):598-603 [807160] Methods Enzymol. 1982;84:223-38 [7048008] Acta Pathol Microbiol Scand. 1960;48:80 [14423425] Infect Immun. 1986 Jun;52(3):786-91 [2423459] Infect Immun. 1988 Apr;56(4):898-902 [2450068] Mol Cell Probes. 1987 Dec;1(4):337-45 [3453424] Infect Immun. 1982 Oct;38(1):14-20 [6183207] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - New food safety initiatives in the Food and Drug Administration. AN - 79688548; 2180882 AB - Concern over the presence of veterinary drug residues in food has been increasing world wide. Because of this concern the Food and Drug Administration's Center for Veterinary Medicine (CVM) has been involved on an international basis in efforts to develop food safety standards for veterinary drugs. The major thrust of the Codex Committee on Residues of Veterinary Drugs in Foods (CC/RVDF) has been to achieve international agreement on veterinary drugs issues. CVM is an active participant on this committee. The CC/RVDF has established a list of priority veterinary drugs that are, or that have the potential to cause trade problems as the result of public health concerns. Included in this list are anabolic hormones, chloramphenicol, sulfonamides, nitrofurans, nitroimidazoles, somatotropins, benzimidazoles and trypanocides. In the upcoming years, the CC/RVDF will work toward developing international maximum residue levels for these compounds. The evaluation of the toxicity of veterinary drug-bound residues is another area of international concern. In conjunction with the Bureau of Veterinary Medicine, Health and Welfare Canada, CVM is developing guidelines on biological models to demonstrate the safety of veterinary drug-bound residues. In working with veterinary drug regulators from other countries, CVM has new solutions to human food safety problems. JF - Journal of animal science AU - Fitzpatrick, S C AD - Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 870 EP - 873 VL - 68 IS - 3 SN - 0021-8812, 0021-8812 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Food Contamination KW - Drug Residues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79688548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+animal+science&rft.atitle=New+food+safety+initiatives+in+the+Food+and+Drug+Administration.&rft.au=Fitzpatrick%2C+S+C&rft.aulast=Fitzpatrick&rft.aufirst=S&rft.date=1990-03-01&rft.volume=68&rft.issue=3&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=Journal+of+animal+science&rft.issn=00218812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-01 N1 - Date created - 1990-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Public health and research perspectives on the microbial contamination of foods. AN - 79685039; 2180884 AB - Scientific advances in methodology and epidemiology have resulted in a renewed awareness of foodborne disease, and increased contact among nations of the world has stimulated rapid global distribution of foods as well as foodborne pathogens. New food vehicles are being identified for old, familiar pathogens, and new pathogens are being discovered. Current research in food microbiology has spurred development of rapid and specific methods to identify these pathogens and to assess their virulence. Organisms of recent interest, such as Bacillus, Yersinia, Campylobacter, Listeria, Sporothrix, Giardia, Cryptosporidium, and Anisakis, are the foci of new investigations, as are the more familiar foodborne pathogens, Salmonella, Shigella, Clostridium, Staphylococcus, Entamoeba and Ascaris. Some foodborne organisms, such as parasitic protozoa, serve as hosts for unique bacterial and viral symbionts but also might become infected with mammalian viruses. The remote possibility of the transmission of human immunodeficiency viruses in foodborne protozoa is discussed. JF - Journal of animal science AU - Jackson, G J AD - Division of Microbiology, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 884 EP - 891 VL - 68 IS - 3 SN - 0021-8812, 0021-8812 KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Humans KW - Food Microbiology KW - Foodborne Diseases -- etiology KW - Acquired Immunodeficiency Syndrome -- transmission KW - Food Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79685039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+animal+science&rft.atitle=Public+health+and+research+perspectives+on+the+microbial+contamination+of+foods.&rft.au=Jackson%2C+G+J&rft.aulast=Jackson&rft.aufirst=G&rft.date=1990-03-01&rft.volume=68&rft.issue=3&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Journal+of+animal+science&rft.issn=00218812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-01 N1 - Date created - 1990-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The benefits of animal identification for food safety. AN - 79684991; 2318742 AB - The Center for Veterinary Medicine supports the effort to have a practical, workable form of mandatory animal identification. An animal identification system will make tracing of the source of animals with drug or chemical residues quicker and more effective. One of the best means of addressing and solving the problem of residues is through mandatory livestock identification. A successful traceback benefits both the producer and the industry. The U.S. Department of Agriculture (USDA) has proposed a mandatory nationwide system to require that all swine in interstate commerce be identified. Under the proposal several means of identification are listed and could be used. Additional methods or devices could be requested in writing to USDA. Persons required to keep records under the system would maintain the documents at their place of business for 2 yr. Records would be available to authorized USDA employees during ordinary business hours. FDA has had difficulty tracing tissue residue violations, particularly those involving sulfamethazine residues in swine. Investigations involving culled dairy cows and veal calves also have been closed due to lack of producer identification. The ability for FDA to determine the source of residues is vitally important in a coordinated government program to eliminate illegal tissue residues. JF - Journal of animal science AU - Augsburg, J K AD - Center for Vet. Med., Food and Drug Administration, Rockville, MD 20857. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 880 EP - 883 VL - 68 IS - 3 SN - 0021-8812, 0021-8812 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Animals, Domestic KW - Government Agencies KW - Food Contamination KW - Animal Identification Systems KW - Food Inspection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79684991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+animal+science&rft.atitle=The+benefits+of+animal+identification+for+food+safety.&rft.au=Augsburg%2C+J+K&rft.aulast=Augsburg&rft.aufirst=J&rft.date=1990-03-01&rft.volume=68&rft.issue=3&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Journal+of+animal+science&rft.issn=00218812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-01 N1 - Date created - 1990-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Military immunizations. Past, present, and future prospects. AN - 79654835; 2407777 AB - The United States military immunizes its forces against a variety of infectious diseases of military importance. Military vaccines can be divided into several categories: (1) routinely administered vaccines for recruits and the total force; (2) deployment-specific vaccines, (3) occupational vaccines based on specific job-associated risks, and (4) experimental limited use vaccines for special contingency situations. New vaccines based on new technological advances are being developed to meet the continuous requirements of the military. JF - Infectious disease clinics of North America AU - Takafuji, E T AU - Russell, P K AD - Office of the Surgeon General, U.S. Army, Falls Church, Virginia. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 143 EP - 158 VL - 4 IS - 1 SN - 0891-5520, 0891-5520 KW - Index Medicus KW - United States KW - Humans KW - Military Personnel KW - Occupational Diseases -- prevention & control KW - Vaccination KW - Immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79654835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+disease+clinics+of+North+America&rft.atitle=Military+immunizations.+Past%2C+present%2C+and+future+prospects.&rft.au=Takafuji%2C+E+T%3BRussell%2C+P+K&rft.aulast=Takafuji&rft.aufirst=E&rft.date=1990-03-01&rft.volume=4&rft.issue=1&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Infectious+disease+clinics+of+North+America&rft.issn=08915520&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-10 N1 - Date created - 1990-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preventing the work-related carpal tunnel syndrome: physician reporting and diagnostic criteria. AN - 79646721; 2407165 JF - Annals of internal medicine AU - Baker, E L AU - Ehrenberg, R L AD - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, GA 30333. Y1 - 1990/03/01/ PY - 1990 DA - 1990 Mar 01 SP - 317 EP - 319 VL - 112 IS - 5 SN - 0003-4819, 0003-4819 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Data Collection -- methods KW - Humans KW - Physician's Role KW - Occupational Diseases -- diagnosis KW - Occupational Diseases -- prevention & control KW - Carpal Tunnel Syndrome -- diagnosis KW - Carpal Tunnel Syndrome -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79646721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Preventing+the+work-related+carpal+tunnel+syndrome%3A+physician+reporting+and+diagnostic+criteria.&rft.au=Baker%2C+E+L%3BEhrenberg%2C+R+L&rft.aulast=Baker&rft.aufirst=E&rft.date=1990-03-01&rft.volume=112&rft.issue=5&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-23 N1 - Date created - 1990-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 1990 May 15;112(10):796 [2331122] N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Seventh Report to the President and Congress on the Status of Health Personnel in the United States. AN - 63066862; ED319999 AB - This document provides selected information on characteristics of health personnel disciplines, students preparing for these disciplines, their schools, projections of the personnel supply in each discipline to the year 2020, and discussions of whether the U.S. requirements for health personnel are likely to be met. Following an introduction, chapter 2 provides an overview of major personnel developments, including trends in education and training, the current supply of health care personnel, issues affecting health personnel, and health personnel in the coming years. Current and emerging health issues and personnel issues are covered in chapters 3 and 4. Among the health issues covered are an aging population, infant mortality, human immune deficiency virus, acquired immunodeficiency syndrome, substance abuse, access to health care, a changing health delivery system, and quality assurance and effectiveness in medical practice. The personnel issues addressed include declining applicants and enrollments, the shortage of nurses, primary health care concerns, concerns regarding allied health and public health labor supply, personnel for health care in geriatrics, and underrepresented minorities in the health professions. Chapter 5 discusses the data and methodology used to produce this report. The next 11 chapters provide information on physicians, dental personnel, nursing personnel, public health personnel, allied health personnel, optometrists, pharmacists, podiatrists, veterinarians, chiropractors, and physician assistants. The document contains reference lists that follow each chapter, 95 tables, and 75 figures. (CML) Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 421 VL - DHHS-HRS-P-OD-90-1 KW - Chiropractors KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Employment Projections KW - Podiatry KW - Nurses KW - Physicians Assistants KW - Adults KW - Pharmacists KW - Occupational Information KW - Public Health KW - Nursing Education KW - Dental Students KW - Physicians KW - Pharmaceutical Education KW - Labor Supply KW - Dental Hygienists KW - Medical Services KW - Medical Schools KW - Optometrists KW - Medical Education KW - Labor Needs KW - Health Occupations KW - Dental Schools KW - Allied Health Occupations Education KW - Dentists KW - Veterinarians UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63066862?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - An Atlas of State Profiles Which Estimate Number of Migrant and Seasonal Farmworkers and Members of Their Families. AN - 62966722; ED332857 AB - This atlas is designed to facilitate planning for health services for migrant and seasonal farmworkers (MSFWs) and for evaluating the extent to which existing programs are reaching the target population. The document estimates how many MSFWs are present in counties of each state, and shows where they work or reside. Chapter 1 introduces the reader to the document and defines the population. Summary profile tables in Chapter 2 provide the estimated aggregate MSFW population, including non-working family members, for the 41 states, including Puerto Rico, that submitted a profile. Chapter 3 provides individual state profiles. Maps display: (1) the distribution of the MSFW population for each state; (2) the locations of major crop areas and seasons; (3) the locations of migrant health centers; and (4) the locations of selected community health centers. Each state section describes adjustments to the profile that were necessary due to differences in methodologies used for developing profiles. Chapter 4 contains names and addresses for sources of information concerning the state profiles. Appendices are provided for: (1) historical estimates and comparative utilization data; (2) profile review issues; and (3) the request for proposal used to solicit bids for the preparation of state profiles. (KS) Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 242 KW - Counties KW - ERIC, Resources in Education (RIE) KW - Health Facilities KW - Farm Labor KW - Migrant Programs KW - Migrant Workers KW - Atlases KW - State Surveys KW - Population Distribution KW - Maps KW - Tables (Data) KW - Migrant Health Services KW - Seasonal Laborers KW - Health Facilities KW - Farm Labor KW - Migrant Programs KW - Migrant Workers KW - Atlases KW - State Surveys KW - Population Distribution KW - Maps KW - Tables (Data) KW - Migrant Health Services KW - Seasonal Laborers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62966722?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Some maps may not reproduce well due to extremely N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Nursing: Seventh Report to the President and Congress on the Status of Health Personnel in the United States. AN - 62949072; ED323854 AB - This report consists of chapter 8 (the chapter on nursing) and relevant other sections of the "Seventh Report to the President and Congress on the Status of Health Personnel in the United States, March 1990." It presents and analyzes recent developments in the education, supply, and distribution of nursing personnel; and provides an assessment of the future supply of and requirements for nursing personnel through the year 2020. An executive summary of the full health personnel report is included. In the reprint of chapter 8 from the full report, s section on current developments in nursing education addresses issues in basic nursing education to prepare for registered nurse (RN) licensure, post-RN academic nursing education, costs of educating nursing students, and programs preparing practical nurses. A discussion of current developments in the registered nurse population examines the registered nurse supply, nurse immigrants, geographic distribution of registered nurses, and distribution of nursing personnel within the health care system. Two final sections discuss, respectively, rates of compensation and the outlook for the future. Other relevant sections of the full report that are reprinted here include the introduction, an overview of major personnel developments for all health personnel, and current and emerging health personnel issues. Includes a total of 34 references. (JDD) Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 87 KW - ERIC, Resources in Education (RIE) KW - Personnel Needs KW - Employment Projections KW - Nursing Education KW - Nurses KW - Geographic Distribution KW - Health Personnel KW - Labor Supply KW - Higher Education KW - Employment Patterns KW - Labor Needs KW - Futures (of Society) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62949072?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Potential misidentification of trichlorophenylethanol in imported peppers. AN - 80399232; 2134339 AB - During regulatory analyses for the determination of pesticide residues on agricultural commodities, a frequently encountered trichlorinated compound was misidentified by the NBS library search routine. This case history illustrates the need for more rigorous confirmation criteria when dealing with multi-chlorinated compounds where fragmentation can be dominated by methyl loss followed by loss of CO and HCI. JF - Rapid communications in mass spectrometry : RCM AU - Cairns, T AU - Siegmund, E G AU - Barry, T L AU - Petzinger, G AD - Food and Drug Administration, Los Angeles District Laboratory, California 90015. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 58 EP - 60 VL - 4 IS - 2 SN - 0951-4198, 0951-4198 KW - Benzyl Alcohols KW - 0 KW - Chlorobenzenes KW - Pesticide Residues KW - 2,4,5-trichlorophenylethanol KW - 14299-54-8 KW - Index Medicus KW - Gas Chromatography-Mass Spectrometry KW - Fruit KW - Benzyl Alcohols -- analysis KW - Pesticide Residues -- analysis KW - Chlorobenzenes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80399232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Potential+misidentification+of+trichlorophenylethanol+in+imported+peppers.&rft.au=Cairns%2C+T%3BSiegmund%2C+E+G%3BBarry%2C+T+L%3BPetzinger%2C+G&rft.aulast=Cairns&rft.aufirst=T&rft.date=1990-02-01&rft.volume=4&rft.issue=2&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-28 N1 - Date created - 1992-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of deoxynivalenol (DON, vomitoxin) in wheat by high-performance liquid chromatography with photolysis and electrochemical detection (HPLC-hv-EC). AN - 80215958; 2273063 AB - Deoxynivalenol (DON, vomitoxin) is a naturally occurring toxic fungal metabolite found in grains such as wheat, corn, rye, and barley. Current methods of analysis for DON and related trichothecene mycotoxins involve gas chromatography with electron capture detection, thin-layer chromatography, and high-performance liquid chromatography with ultraviolet detection. Improved sensitivity and selectivity for DON, as well as for the related compounds nivalenol and fusarenon-X, are made possible by the use of high-performance liquid chromatography with online, postcolumn photolysis and oxidative amperometric detection (HPLC-hv-EC). Conditions are optimized with respect to residence time in the photolytic reactor, applied potentials, mobile phase pH, and chromatographic parameters for the separation of DON, nivalenol, and fusarenon-X, and the technique is found to be linear over a range of 10 ppb-2 ppm with minimum detection limits on the order of 1-2 ng on-column (10-20 ppb). Since these compounds are not electroactive in the absence of photolysis, an additional mode of specificity is realized in addition to the chromatographic retention time and the dual-electrode response ratio. Some market samples of wheat naturally contaminated with DON are analyzed by this method, and the results are in agreement with those obtained by HPLC-UV and TLC analyses of the same samples. JF - Journal of chromatographic science AU - Childress, W L AU - Krull, I S AU - Selavka, C M AD - U.S. Food and Drug Administration, Winchester, Massachusetts 01890. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 76 EP - 82 VL - 28 IS - 2 SN - 0021-9665, 0021-9665 KW - Trichothecenes KW - 0 KW - deoxynivalenol KW - JT37HYP23V KW - Index Medicus KW - Electrochemistry KW - Photolysis KW - Chromatography, High Pressure Liquid -- methods KW - Trichothecenes -- analysis KW - Triticum -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80215958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Determination+of+deoxynivalenol+%28DON%2C+vomitoxin%29+in+wheat+by+high-performance+liquid+chromatography+with+photolysis+and+electrochemical+detection+%28HPLC-hv-EC%29.&rft.au=Childress%2C+W+L%3BKrull%2C+I+S%3BSelavka%2C+C+M&rft.aulast=Childress&rft.aufirst=W&rft.date=1990-02-01&rft.volume=28&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-25 N1 - Date created - 1991-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relevance of maximum tolerated dose to human carcinogenic risk. AN - 79734728; 2184467 JF - Regulatory toxicology and pharmacology : RTP AU - Apostolou, A AD - Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 68 EP - 80 VL - 11 IS - 1 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Maximum Allowable Concentration KW - Humans KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79734728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Relevance+of+maximum+tolerated+dose+to+human+carcinogenic+risk.&rft.au=Apostolou%2C+A&rft.aulast=Apostolou&rft.aufirst=A&rft.date=1990-02-01&rft.volume=11&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-30 N1 - Date created - 1990-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nonclinical toxicity studies of antiviral drugs indicated for the treatment of non-life-threatening diseases: evaluation of drug toxicity prior to phase 1 clinical studies. AN - 79734403; 2184468 AB - The types of nonclinical toxicity studies conducted during the preclinical research and development of antiviral drugs intended for the treatment of non-life-threatening diseases in humans are reviewed. This guidance also applies to other classes of drugs under development for non-life-threatening diseases that fall under the regulatory responsibility of the Food and Drug Administration's Division of Antiviral Drug Products, including systemic antifungals, antimycobacterials, and immunomodulators. JF - Regulatory toxicology and pharmacology : RTP AU - Hoyle, P C AU - Cooper, E C AD - Division of Antiviral Drug Products, U.S. Food and Drug Administration, Rockville, Maryland 20875. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 81 EP - 89 VL - 11 IS - 1 SN - 0273-2300, 0273-2300 KW - Antiviral Agents KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Terminology as Topic KW - Drug Evaluation, Preclinical KW - Antiviral Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79734403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Nonclinical+toxicity+studies+of+antiviral+drugs+indicated+for+the+treatment+of+non-life-threatening+diseases%3A+evaluation+of+drug+toxicity+prior+to+phase+1+clinical+studies.&rft.au=Hoyle%2C+P+C%3BCooper%2C+E+C&rft.aulast=Hoyle&rft.aufirst=P&rft.date=1990-02-01&rft.volume=11&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-30 N1 - Date created - 1990-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro. AN - 79730952; 2158278 AB - Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity. JF - Antimicrobial agents and chemotherapy AU - Manischewitz, J F AU - Quinnan, G V AU - Lane, H C AU - Wittek, A E AD - Laboratory of Herpesvirus Research, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 373 EP - 375 VL - 34 IS - 2 SN - 0066-4804, 0066-4804 KW - DNA, Viral KW - 0 KW - Foscarnet KW - 364P9RVW4X KW - Phosphonoacetic Acid KW - N919E46723 KW - Ganciclovir KW - P9G3CKZ4P5 KW - Index Medicus KW - DNA, Viral -- biosynthesis KW - Drug Synergism KW - Cytomegalovirus -- physiology KW - Virus Replication -- drug effects KW - Phosphonoacetic Acid -- analogs & derivatives KW - Phosphonoacetic Acid -- pharmacology KW - Cytomegalovirus -- drug effects KW - Ganciclovir -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79730952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Synergistic+effect+of+ganciclovir+and+foscarnet+on+cytomegalovirus+replication+in+vitro.&rft.au=Manischewitz%2C+J+F%3BQuinnan%2C+G+V%3BLane%2C+H+C%3BWittek%2C+A+E&rft.aulast=Manischewitz&rft.aufirst=J&rft.date=1990-02-01&rft.volume=34&rft.issue=2&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 1974 Jul;130(1):32-9 [4366288] Ann Intern Med. 1988 Nov 15;109(10):783-8 [2847610] Am J Med. 1982 Jul 20;73(1A):249-56 [6285716] Antimicrob Agents Chemother. 1983 Oct;24(4):518-21 [6316844] Ann N Y Acad Sci. 1984;437:383-93 [6100005] Scand J Infect Dis. 1985;17(2):157-63 [2992074] Ann Intern Med. 1985 Sep;103(3):368-73 [2992333] J Infect Dis. 1985 Oct;152(4):833-4 [2995505] Ann Intern Med. 1986 Jan;104(1):41-4 [3000248] J Infect Dis. 1986 Mar;153(3):478-88 [3005424] J Antimicrob Chemother. 1986 Mar;17(3):373-87 [3009383] J Med Virol. 1987 Jun;22(2):157-62 [3039052] J Infect Dis. 1988 Mar;157(3):569-72 [2830347] Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4 [2847285] Ann Intern Med. 1988 Nov 15;109(10):777-82 [2847609] Medicine (Baltimore). 1980 Jul;59(4):283-300 [6248718] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Levels of metals in canned meat products: intermetallic correlations. AN - 79706726; 2322673 JF - Bulletin of environmental contamination and toxicology AU - Brito, G AU - Díaz, C AU - Galindo, L AU - Hardisson, A AU - Santiago, D AU - García Montelongo, F AD - Canary Islands Public Health Service, Santa Cruz de Tenerife, Spain. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 309 EP - 316 VL - 44 IS - 2 SN - 0007-4861, 0007-4861 KW - Metals KW - 0 KW - Index Medicus KW - Swine KW - Animals KW - European Union KW - Spectrophotometry, Atomic KW - Food Contamination -- analysis KW - Meat -- analysis KW - Metals -- analysis KW - Food Preservation KW - Meat Products -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79706726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+environmental+contamination+and+toxicology&rft.atitle=Levels+of+metals+in+canned+meat+products%3A+intermetallic+correlations.&rft.au=Brito%2C+G%3BD%C3%ADaz%2C+C%3BGalindo%2C+L%3BHardisson%2C+A%3BSantiago%2C+D%3BGarc%C3%ADa+Montelongo%2C+F&rft.aulast=Brito&rft.aufirst=G&rft.date=1990-02-01&rft.volume=44&rft.issue=2&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+environmental+contamination+and+toxicology&rft.issn=00074861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-18 N1 - Date created - 1990-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of lithium carbonate on mouse and rat embryos in vitro. AN - 79696108; 2108509 AB - Lithium is effective in the treatment of manic-depressive psychosis but is suspected to be a developmental toxicant in humans. It is a developmental toxicant in mice and rats in vivo, but at human therapeutic serum levels of 0.6-1.6 meq/L, rats appear to be more sensitive to the effects of the drug than do mice. The species susceptibility to lithium-induced defects was evaluated by using a rodent whole embryo culture system employing mouse and rat embryos treated at comparable developmental stages. Mouse embryos were cultured on gestational days 8-10, and rat embryos were cultured on gestational days 10-12. Care was taken to insure that all embryos had 10 +/- 2 somite pairs at the beginning of the culture period. Embryos were cultured for 44 hours in rat serum to which lithium was added to attain final drug concentrations of 0.6, 1.2, 1.8, 2.4, or 5.0 meq/L. Control embryos were treated with distilled water, which served as the vehicle. In rats, lithium induced significant decreases in various parameters at 1.8, 2.4, and 5.0 meq/L; no malformations were observed in rats of this stage. In mice, significant decreases occurred at 2.4 and 5.0 meq/L, and embryos treated at the highest concentration had a significantly increased frequency of open neural tubes. Rat embryos were also cultured with lithium on gestational days 9-11. The lowest dose producing developmental toxicity at this stage was 0.6 meq/L. Open neural tubes were present among younger rat embryos; however, this defect occurred in all groups, including the control group.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Teratology AU - Hansen, D K AU - Walker, R C AU - Grafton, T F AD - Food and Drug Administration, Department of Health and Human Services, Jefferson, Arkansas 72079-9502. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 155 EP - 160 VL - 41 IS - 2 SN - 0040-3709, 0040-3709 KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Neural Tube Defects -- chemically induced KW - Mice KW - Fetal Death -- chemically induced KW - Species Specificity KW - Female KW - Pregnancy KW - Embryonic and Fetal Development -- drug effects KW - Lithium -- toxicity KW - Embryo, Mammalian -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79696108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Effect+of+lithium+carbonate+on+mouse+and+rat+embryos+in+vitro.&rft.au=Hansen%2C+D+K%3BWalker%2C+R+C%3BGrafton%2C+T+F&rft.aulast=Hansen&rft.aufirst=D&rft.date=1990-02-01&rft.volume=41&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-08 N1 - Date created - 1990-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethylene dichloride: the influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats. AN - 79690757; 2318350 AB - Male and female Sprague-Dawley rats were exposed to 50 ppm ethylene dichloride (EDC) for 7 hr/day, 5 days/week, for 2 years by inhalation. Additional rats were exposed to 50 ppm EDC either with 0.05% disulfiram in the diet or with 5% ethanol in the drinking water. Histopathologic lesions related to the combination of inhaled EDC and dietary disulfiram were observed in the liver, mammary, and testicular tissues of rats. This combined exposure resulted in a significant increase in the incidence of intrahepatic bile duct cholangiomas in both male and female rats. Male rats exposed to both EDC and disulfiram also had an increased incidence of subcutaneous fibromas, neoplastic nodules, and interstitial cell tumors in the testes. The female rats exposed to EDC and disulfiram also had a higher incidence of mammary adenocarcinomas. No significant increase in the number of any tumor type was observed in rats exposed to only EDC, disulfiram, or ethanol. Similarly, no significant increase in the number of tumors was observed in rats exposed to inhaled EDC and ethanol in water. At the end of the 2-year period animals from each group were evaluated for EDC metabolism and DNA binding. Blood levels of EDC at the end of a 7-hr exposure period were significantly higher for rats exposed to both EDC and disulfiram than for rats exposed to EDC alone. In addition, the elimination of a single oral dose of radiolabeled EDC was affected. The urinary excretion of 14C from control rats was 47 to 55% of the administered dose with 28 to 30% detected as unchanged EDC in the breath. In disulfiram-treated rats, only 35 to 36% of the administered 14C was eliminated in the urine with 41 to 55% as unchanged EDC in the breath. The urinary metabolite HPLC profile was qualitatively unchanged by long-term EDC, disulfiram, or ethanol treatment, either alone or in combination, and consisted primarily of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and chloroacetic acid. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Cheever, K L AU - Cholakis, J M AU - el-Hawari, A M AU - Kovatch, R M AU - Weisburger, E K AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 243 EP - 261 VL - 14 IS - 2 SN - 0272-0590, 0272-0590 KW - Carcinogens KW - 0 KW - Ethylene Dichlorides KW - Hydrocarbons, Chlorinated KW - Ethanol KW - 3K9958V90M KW - ethylene dichloride KW - 55163IJI47 KW - DNA KW - 9007-49-2 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Mammary Glands, Animal -- drug effects KW - Sex Factors KW - Rats KW - Rats, Inbred Strains KW - Skin -- drug effects KW - Testis -- drug effects KW - Drinking -- drug effects KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Drug Synergism KW - Female KW - Male KW - Ethylene Dichlorides -- metabolism KW - Hydrocarbons, Chlorinated -- toxicity KW - DNA -- metabolism KW - Ethylene Dichlorides -- toxicity KW - Ethanol -- toxicity KW - Disulfiram -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79690757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Ethylene+dichloride%3A+the+influence+of+disulfiram+or+ethanol+on+oncogenicity%2C+metabolism%2C+and+DNA+covalent+binding+in+rats.&rft.au=Cheever%2C+K+L%3BCholakis%2C+J+M%3Bel-Hawari%2C+A+M%3BKovatch%2C+R+M%3BWeisburger%2C+E+K&rft.aulast=Cheever&rft.aufirst=K&rft.date=1990-02-01&rft.volume=14&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-08 N1 - Date created - 1990-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 4,4'-Methylene-bis(2-chloroaniline) (MOCA): comparison of macromolecular adduct formation after oral or dermal administration in the rat. AN - 79684340; 2318352 AB - The macromolecular binding of 4,4'-methylenebis(2-chloroaniline) (MOCA), a suspect human carcinogen, was studied in the adult male Sprague-Dawley rat after both oral and dermal administration. Rats were euthanized 1, 3, 7, 10, 14, and 29 days after a single 281 mumol/kg body wt dose of [14C]MOCA (oral, 213 muCi/kg; dermal, 904 muCi/kg). DNA from various tissues and hemoglobin were isolated for determination of the time course of MOCA macromolecular binding. After oral administration adduct formation was rapid with maximum levels appearing at 24 hr. The 24-hr covalent binding associated with the globin was 7.84 pmol/mg globin (t1/2 = 14.3 days). More extensive 24-hr covalent binding was detected for liver DNA with 49.11 pmol/mg DNA (t1/2 = 11.1 days). After dermal administration of MOCA the major portion of the dose, 86.2%, remained at the application site throughout the study. For these rats the 24-hr covalent binding determined for liver DNA was 0.38 pmol/mg DNA (t1/2 = 15.6 days). Although lower levels were detected after dermal application, similar stability of MOCA-DNA adducts indicates that quantification of such MOCA adducts may be useful for the long-term industrial biomonitoring of MOCA exposure and for the evaluation of human DNA-MOCA adduct formation, a lesion thought to be associated with the production of cancer. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Cheever, K L AU - Richards, D E AU - Weigel, W W AU - Begley, K B AU - DeBord, D G AU - Swearengin, T F AU - Savage, R E AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 273 EP - 283 VL - 14 IS - 2 SN - 0272-0590, 0272-0590 KW - Benzhydryl Compounds KW - 0 KW - Hemoglobins KW - Methylenebis(chloroaniline) KW - 3L2W5VTT2A KW - Hemin KW - 743LRP9S7N KW - Globins KW - 9004-22-2 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Globins -- isolation & purification KW - Administration, Cutaneous KW - Scintillation Counting KW - Protein Binding KW - Chromatography, High Pressure Liquid KW - Rats KW - Rats, Inbred Strains KW - Half-Life KW - Hemin -- isolation & purification KW - Subcellular Fractions -- analysis KW - Male KW - Methylenebis(chloroaniline) -- metabolism KW - Hemoglobins -- metabolism KW - DNA -- metabolism KW - Benzhydryl Compounds -- metabolism KW - Methylenebis(chloroaniline) -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79684340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=4%2C4%27-Methylene-bis%282-chloroaniline%29+%28MOCA%29%3A+comparison+of+macromolecular+adduct+formation+after+oral+or+dermal+administration+in+the+rat.&rft.au=Cheever%2C+K+L%3BRichards%2C+D+E%3BWeigel%2C+W+W%3BBegley%2C+K+B%3BDeBord%2C+D+G%3BSwearengin%2C+T+F%3BSavage%2C+R+E&rft.aulast=Cheever&rft.aufirst=K&rft.date=1990-02-01&rft.volume=14&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-08 N1 - Date created - 1990-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pimozide in delusions of parasitosis. AN - 79675885; 2312815 JF - Journal of the American Academy of Dermatology AU - Damiani, J T AU - Flowers, F P AU - Pierce, D K AD - U.S. Public Health Service, Cross City, FL. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 312 EP - 313 VL - 22 IS - 2 Pt 1 SN - 0190-9622, 0190-9622 KW - Pimozide KW - 1HIZ4DL86F KW - Index Medicus KW - Pruritus -- drug therapy KW - Humans KW - Aged KW - Female KW - Pimozide -- therapeutic use KW - Pimozide -- adverse effects KW - Skin Diseases, Parasitic -- psychology KW - Delusions -- drug therapy KW - Pimozide -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79675885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Pimozide+in+delusions+of+parasitosis.&rft.au=Damiani%2C+J+T%3BFlowers%2C+F+P%3BPierce%2C+D+K&rft.aulast=Damiani&rft.aufirst=J&rft.date=1990-02-01&rft.volume=22&rft.issue=2+Pt+1&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-25 N1 - Date created - 1990-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholera holotoxin and its B subunit enhance Peyer's patch B cell responses induced by orally administered influenza virus: disproportionate cholera toxin enhancement of the IgA B cell response. AN - 79663198; 2311649 AB - In these studies we analyzed the adjuvant effect of cholera holotoxin or cholera toxin (CT) B subunit on the B cell response to mucosal antigens. Purified Peyer's patch B cells obtained from mice at varying periods of time after oral administration of inactivated influenza virus, with or without a CT preparation, were stimulated in vitro in the absence or presence of various lymphokines. Responses were measured by an antigen- and isotype-specific ELISPOT assay. In this system cultures containing a combination of lymphokines [interleukin 5 (IL 5), interferon-gamma (IFN-gamma), IL 4] gave comparable responses to those containing T cells from immunized mice or supernatant of concanavalin A-stimulated T cells and therefore were assumed to express optimum or near optimum B cell responses. Administration of a CT preparation along with influenza virus increased the number of B cells producing anti-influenza antibodies of both the IgM and IgA isotypes, with the effect on the IgA response at least threefold greater than the effect on the IgM response. These results thus indicate that CT preparations enhance the memory B cells response in Peyer's patches and, in addition, suggest that CT enhances isotype switching. In this antigen-specific B cell system IL 4 augmented responses in cultures containing IL 5 but not IFN-gamma; in addition, IL 5 and IFN-gamma acted in an additive fashion. Thus, these findings suggest that the effects of IL 5 and IFN-gamma are at least in part, mediated via different cellular differentiation pathways. JF - European journal of immunology AU - Chen, K S AU - Strober, W AD - Center for Biologies Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 433 EP - 436 VL - 20 IS - 2 SN - 0014-2980, 0014-2980 KW - Adjuvants, Immunologic KW - 0 KW - Immunoglobulin A KW - Immunoglobulin M KW - Lymphokines KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Intestinal Mucosa -- immunology KW - Cells, Cultured KW - Lymphokines -- pharmacology KW - In Vitro Techniques KW - Immunologic Memory KW - Influenza A virus -- immunology KW - Mice KW - Immunoglobulin M -- biosynthesis KW - Mice, Inbred BALB C KW - Female KW - Peyer's Patches -- immunology KW - Cholera Toxin -- immunology KW - B-Lymphocytes -- immunology KW - Immunoglobulin A -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79663198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=Cholera+holotoxin+and+its+B+subunit+enhance+Peyer%27s+patch+B+cell+responses+induced+by+orally+administered+influenza+virus%3A+disproportionate+cholera+toxin+enhancement+of+the+IgA+B+cell+response.&rft.au=Chen%2C+K+S%3BStrober%2C+W&rft.aulast=Chen&rft.aufirst=K&rft.date=1990-02-01&rft.volume=20&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-23 N1 - Date created - 1990-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Electrostatic effects in asbestos sampling. II: Comparison of theory and experiment. AN - 79653778; 2305675 AB - A series of calculations was conducted to estimate the degree and type of electrostatic interactions that might occur with electrically charged asbestos samplers collecting charged particles. Relatively simple theoretical models were constructed assuming only charge-charge electrostatic interactions between a charged particle and a charged sampler. The results of these calculations were compared with some experimental measurements and the agreement between the two allowed some confidence in predicting behavior trends. Under conditions where both the particles and the sampler are charged, the nonconductive sampler exhibits increased particle loss, especially near the filter edge, and increased variability of the particle deposit. The variability of the deposit also tends to be greatest near the filter edge. Under similar conditions, conductive cowled samplers also can be expected to exhibit losses in particle deposit, especially near the filter edge. The variability over the filter surface, however, is less than for the nonconductive cowl. Particle collection onto the sampler filter generally is expected to be greatest for isokinetic, isoaxial sampling conditions. Particle collection on the filter decreases with lower sampling flow rates, lower air velocities near the sampler inlet, and increased turbulence near the inlet. JF - American Industrial Hygiene Association journal AU - Baron, P A AU - Deye, G J AD - Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 63 EP - 69 VL - 51 IS - 2 SN - 0002-8894, 0002-8894 KW - Air Pollutants KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Models, Theoretical KW - Asbestos -- analysis KW - Electricity KW - Air Pollutants -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79653778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Electrostatic+effects+in+asbestos+sampling.+II%3A+Comparison+of+theory+and+experiment.&rft.au=Baron%2C+P+A%3BDeye%2C+G+J&rft.aulast=Baron&rft.aufirst=P&rft.date=1990-02-01&rft.volume=51&rft.issue=2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-29 N1 - Date created - 1990-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational and other exposures associated with male end-stage renal disease: a case/control study. AN - 79595661; 2153349 AB - We conducted a case-control study of 325 men ages 30-69 who were diagnosed with end-stage renal disease (ESRD) between 1976 and 1984, and resided in four urban areas of Michigan in 1984. Cases were selected from the Michigan Kidney Registry and excluded men with diabetic, congenital, and obstructive nephropathies. Controls were selected by random-digit dialing and were pair-matched to cases for age, race, and area of residence. Telephone interviews were conducted with 69 percent of eligible cases and 79 percent of eligible controls. Risk of ESRD was significantly related to phenacetin or acetaminophen consumption (odds ratio(OR) = 2.66), moonshine consumption (OR = 2.43), a family history of renal disease (OR = 9.30); and regular occupational exposures to solvents (OR = 1.51) or silica (OR = 1.67). Particular occupational exposures with elevated risk were solvents used as cleaning agents and degreasers (OR = 2.50) silica exposure in foundries or brick factories (OR = 1.92), and silica exposure during sandblasting (OR = 3.83). Little or no trend of increased risk with duration of exposure was found for these occupational exposures, with the exception of silica in sandblasting. Limitations of these data include representativeness of cases, possible overreporting by cases, and misclassification of exposures inherent in self-reports. JF - American journal of public health AU - Steenland, N K AU - Thun, M J AU - Ferguson, C W AU - Port, F K AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 153 EP - 157 VL - 80 IS - 2 SN - 0090-0036, 0090-0036 KW - Analgesics KW - 0 KW - Solvents KW - Ethanol KW - 3K9958V90M KW - Silicon Dioxide KW - 7631-86-9 KW - Abridged Index Medicus KW - Index Medicus KW - Regression Analysis KW - Odds Ratio KW - Humans KW - Solvents -- adverse effects KW - Aged KW - Analgesics -- adverse effects KW - Silicon Dioxide -- adverse effects KW - Ethanol -- adverse effects KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Male KW - Michigan -- epidemiology KW - Kidney Failure, Chronic -- genetics KW - Environmental Exposure KW - Kidney Failure, Chronic -- chemically induced KW - Kidney Failure, Chronic -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79595661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Occupational+and+other+exposures+associated+with+male+end-stage+renal+disease%3A+a+case%2Fcontrol+study.&rft.au=Steenland%2C+N+K%3BThun%2C+M+J%3BFerguson%2C+C+W%3BPort%2C+F+K&rft.aulast=Steenland&rft.aufirst=N&rft.date=1990-02-01&rft.volume=80&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-15 N1 - Date created - 1990-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1985 Oct;122(4):673-83 [4025307] Kidney Int. 1985 Aug;28(2):212-20 [3834232] Arch Environ Health. 1984 May-Jun;39(3):225-30 [6380428] Lancet. 1983 Nov 26;2(8361):1214-6 [6139568] Nephron. 1983;33(3):169-72 [6843743] Br J Ind Med. 1982 Nov;39(4):404-10 [7138801] J Occup Med. 1982 May;24(5):375-8 [7086551] Kidney Int. 1982 Jan;21(1):78-83 [7043052] Am J Med. 1981 Nov;71(5):823-8 [6272574] Clin Nephrol. 1980 Oct;14(4):173-5 [7428191] Am J Nephrol. 1985;5(2):84-95 [3887922] Scand J Work Environ Health. 1985;11 Suppl 1:83-90 [3906873] Arch Pathol Lab Med. 1980 Feb;104(2):94-9 [6892556] Acta Med Scand. 1979;205(7):575-9 [474184] Am J Med. 1978 Feb;64(2):336-42 [343591] Lancet. 1975 Aug 2;2(7927):199-201 [51959] N Engl J Med. 1989 May 11;320(19):1238-43 [2651928] Br J Ind Med. 1988 Jan;45(1):70-2 [3342190] Scand J Work Environ Health. 1985 Oct;11(5):331-45 [4070998] Comment In: Am J Public Health. 1990 Oct;80(10):1275-6 [2271034] Am J Public Health. 1991 Apr;81(4):514-5 [2003642] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anticipating, recognizing, and preventing hazards associated with in vivo use of monoclonal antibodies: special considerations related to human anti-mouse antibodies. AN - 79593702; 2297719 AB - The advent of monoclonal antibodies offers abundant potential benefits to diagnosis and therapy of many conditions. However, with widespread use come greater concerns regarding possible side effects and complications. Antibodies, including monoclonals, react with antigens which may be represented on tissues other than those to which they were raised. Although histochemical surveys of tissues may be performed, these may not necessarily be predictive of in vivo cross-reactivities. This consideration mandates carefully performed preclinical toxicological studies prior to use in humans. For murine monoclonal antibodies, the type most commonly available, issues related to potential immunogenicity are of paramount concern. Very little substantive information has accrued regarding the prevalence of these antibodies in the general population, the mechanism by which these antibodies are elicited, or the predictive value of assays for their detection. This knowledge is crucial for the development of strategies for blunting or controlling the human anti-mouse antibody response. Contaminants in manufactured monoclonals also pose inherent danger to recipients. Among those commonly encountered are microbes, DNA, and manufacturing reagents (e.g., sera, column components, and tissue culture additives). Strict adherence to proper manufacturing technique usually will minimize these concerns. However, in the absence of well-defined cause/effect relationships between toxicity (theoretical or real) and agent, complacency that a given product is safe is ill-advised. The Food and Drug Administration has disseminated a compilation of concerns and suggestions for addressing them in the document "Points to consider in the manufacture and testing of monoclonal antibody products for human use." The precepts outlined in that document and a close working relationship between manufacturers of monoclonal products and scientifically astute regulators together represent an effective approach to minimizing the risks of monoclonal therapy in diverse patient populations. JF - Cancer research AU - Hoffman, T AD - Division of Blood and Blood Products, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1990/02/01/ PY - 1990 DA - 1990 Feb 01 SP - 1049s EP - 1050s VL - 50 IS - 3 Suppl SN - 0008-5472, 0008-5472 KW - Antibodies, Anti-Idiotypic KW - 0 KW - Antibodies, Monoclonal KW - Index Medicus KW - Animals KW - Humans KW - Antibodies, Anti-Idiotypic -- analysis KW - Mice KW - Antibodies, Monoclonal -- adverse effects KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79593702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Anticipating%2C+recognizing%2C+and+preventing+hazards+associated+with+in+vivo+use+of+monoclonal+antibodies%3A+special+considerations+related+to+human+anti-mouse+antibodies.&rft.au=Hoffman%2C+T&rft.aulast=Hoffman&rft.aufirst=T&rft.date=1990-02-01&rft.volume=50&rft.issue=3+Suppl&rft.spage=1049s&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-13 N1 - Date created - 1990-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - National Health Line AN - 61597894; 199001383 AB - A review of environmental & patient health care issues of national importance that affect social work practitioners, including: health care quality accreditation; equity in resource distribution; hospital competition; & growing concern for the increasing numbers of patients with specialized needs, eg, acquired immune deficiency syndrome & human immunodeficiency virus-infected patients, drug abusers, & elderly minorities. 23 References. M. Malas JF - Health and Social Work AU - Leukefeld, Carl G AD - US Public Health Service National Instit Drug Abuse, 5600 Fishers Ln Rockville MD 20852 Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 10 EP - 14 VL - 15 IS - 1 SN - 0360-7283, 0360-7283 KW - environmental/health care issues, social work practice implications, US KW - Health Care KW - Environmentalism KW - Health Problems KW - United States of America KW - Social Work Cases KW - Environmental Factors KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61597894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+and+Social+Work&rft.atitle=National+Health+Line&rft.au=Leukefeld%2C+Carl+G&rft.aulast=Leukefeld&rft.aufirst=Carl&rft.date=1990-02-01&rft.volume=15&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Health+and+Social+Work&rft.issn=03607283&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Environmentalism; Environmental Factors; Health Care; Health Problems; United States of America; Social Work Cases ER - TY - JOUR T1 - Alignment of Escherichia coli K12 DNA sequences to a genomic restriction map. AN - 19623829; 8744553 AB - We use the extensive published information describing the genome of Escherichia coli and new restriction map alignment software to align DNA sequence, genetic, and physical maps. Restriction map alignment software is used which considers restriction maps as strings analogous to DNA or protein sequences except that two values, enzyme name and DNA base address, are associated with each position on the string. The resulting alignments reveal a nearly linear relationship between the physical and genetic maps of the E. coli chromosome. Physical map comparisons with the 1976, 1980, and 1983 genetic maps demonstrate a better fit with the more recent maps. The results of these alignments are genomic kilobase coordinates, orientation and rank of the alignment that best fits the genetic data. A statistical measure based on extreme value distribution is applied to the alignments. Additional computer analyses allow us to estimate the accuracy of the published E. coli genomic restriction map, simulate rearrangements of the bacterial chromosome, and search for repetitive DNA. The procedures we used are general enough to be applicable to other genome mapping projects. JF - Nucleic Acids Research AU - Rudd, K E AU - Miller, W AU - Ostell, J AU - Benson, D A AD - Division of Bacterial Products, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990/01/25/ PY - 1990 DA - 1990 Jan 25 SP - 313 EP - 321 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 18 IS - 2 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Statistics KW - Data processing KW - Nucleotide sequence KW - Enzymes KW - Computer applications KW - Computer programs KW - Chromosomes KW - software KW - Escherichia coli KW - genomics KW - Repeated DNA sequences KW - Gene mapping KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19623829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Alignment+of+Escherichia+coli+K12+DNA+sequences+to+a+genomic+restriction+map.&rft.au=Rudd%2C+K+E%3BMiller%2C+W%3BOstell%2C+J%3BBenson%2C+D+A&rft.aulast=Rudd&rft.aufirst=K&rft.date=1990-01-25&rft.volume=18&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Computer programs; software; Chromosomes; Data processing; Statistics; Nucleotide sequence; Enzymes; genomics; Computer applications; Repeated DNA sequences; Gene mapping; Escherichia coli ER - TY - JOUR T1 - The NIOSH study of reproductive outcomes among video display terminal operators. AN - 80408108; 2136023 JF - Reproductive toxicology (Elmsford, N.Y.) AU - Schnorr, T M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1990 PY - 1990 DA - 1990 SP - 61 EP - 65 VL - 4 IS - 1 SN - 0890-6238, 0890-6238 KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Stress, Psychological KW - Adult KW - Female KW - Pregnancy KW - Abnormalities, Radiation-Induced -- epidemiology KW - Occupational Exposure KW - Reproduction -- radiation effects KW - Computer Terminals KW - National Institute for Occupational Safety and Health (U.S.) KW - Pregnancy Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80408108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=The+NIOSH+study+of+reproductive+outcomes+among+video+display+terminal+operators.&rft.au=Schnorr%2C+T+M&rft.aulast=Schnorr&rft.aufirst=T&rft.date=1990-01-01&rft.volume=4&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-20 N1 - Date created - 1992-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of metabolites from degradation of naphthalene by a Mycobacterium sp. AN - 80407050; 1368473 AB - A Mycobacterium sp. isolated from oil-contaminated sediments was previously shown to mineralize 55% of the added naphthalene to carbon dioxide after 7 days of incubation. In this paper, we report the initial steps of the degradation of naphthalene by a Mycobacterium sp. as determined by isolation of metabolites and incorporation of oxygen from 18O2 into the metabolites. The results indicate that naphthalene is initially converted to cis- and trans-1,2-dihydroxy-1,2-dihydronaphthalene by dioxygenase and monooxygenase catalyzed reactions, respectively. The ratio of the cis to trans-naphthalene dihydrodiol isomers was approximately 25: 1. Thin layer and high pressure liquid chromatographic and mass spectrometric techniques indicated that besides the cis- and trans-1,2-dihydroxy-1,2-dihydronaphthalene, minor amounts of ring cleavage products salicylate and catechol were also formed. Thus the formation of both cis and trans-naphthalene dihydrodiols by the Mycobacterium sp. is unique. The down-stream reactions to ring cleavage products proceed through analogous dioxygenase reactions previously reported for the bacterial degradation of naphthalene. JF - Biodegradation AU - Kelley, I AU - Freeman, J P AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 283 EP - 290 VL - 1 IS - 4 SN - 0923-9820, 0923-9820 KW - Naphthalenes KW - 0 KW - naphthalene KW - 2166IN72UN KW - Oxygen KW - S88TT14065 KW - Biotechnology KW - Oxygen -- metabolism KW - Biodegradation, Environmental KW - Hydrolysis KW - Naphthalenes -- metabolism KW - Naphthalenes -- chemistry KW - Mycobacterium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80407050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biodegradation&rft.atitle=Identification+of+metabolites+from+degradation+of+naphthalene+by+a+Mycobacterium+sp.&rft.au=Kelley%2C+I%3BFreeman%2C+J+P%3BCerniglia%2C+C+E&rft.aulast=Kelley&rft.aufirst=I&rft.date=1990-01-01&rft.volume=1&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Biodegradation&rft.issn=09239820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-06 N1 - Date created - 1992-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pharmacokinetics of 2,4,5-T in mice as a function of dose and gestational status. AN - 80406395; 2136028 AB - A pharmacokinetic study was conducted in CD-1 mice with the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) as a function of dose (15, 30, 60, and 90 mg/kg, iv) and gestational status (nonpregnant, day 6, 10, 13, and 17 of gestation, and postpartum). Analysis for 2,4,5-T and its metabolites was based on an electron-capture gas-liquid chromatographic method. Pharmacokinetic stimulation of the blood, urine, and feces data from each mouse was performed on an analog-digital hybrid computer system based on a two-compartment model with parallel, first-order elimination kinetics. Data analysis demonstrated dose-independent kinetics for most pharmacokinetic parameters but a gestational status-dependence. There was a tendency, as indicated by an increase in the biologic half-life and AUC and decrease in clearance and total percent recovery, for pregnant animals to eliminate 2,4,5-T more slowly as gestation progressed, resulting in potentially increasing fetal exposure during the later stages of pregnancy. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Bazare, J J AU - Nelson, C J AU - Young, J F AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1990 PY - 1990 DA - 1990 SP - 137 EP - 144 VL - 4 IS - 2 SN - 0890-6238, 0890-6238 KW - 2,4,5-Trichlorophenoxyacetic Acid KW - 9Q963S4YMX KW - Index Medicus KW - Abnormalities, Drug-Induced -- pathology KW - Animals KW - Fetus -- drug effects KW - Chromatography, Gas KW - Mice KW - Feces -- chemistry KW - Fetus -- metabolism KW - Models, Biological KW - Pregnancy KW - Computers, Hybrid KW - Half-Life KW - Embryo, Mammalian -- drug effects KW - Female KW - Pregnancy, Animal -- metabolism KW - 2,4,5-Trichlorophenoxyacetic Acid -- pharmacokinetics KW - 2,4,5-Trichlorophenoxyacetic Acid -- toxicity KW - 2,4,5-Trichlorophenoxyacetic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80406395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Pharmacokinetics+of+2%2C4%2C5-T+in+mice+as+a+function+of+dose+and+gestational+status.&rft.au=Bazare%2C+J+J%3BNelson%2C+C+J%3BYoung%2C+J+F&rft.aulast=Bazare&rft.aufirst=J&rft.date=1990-01-01&rft.volume=4&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-20 N1 - Date created - 1992-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenic aromatic amine metabolism and DNA adduct detection in humans. AN - 80400790; 2134686 AB - Human exposure to carcinogenic aromatic amines can occur from a variety of sources, including cigarette smoke and cooked foods. Initial metabolism occurs primarily in the liver and involves N-hydroxylation by cytochrome P-450IA2 and N-acetylation by acetyltransferase, which serve as competing activation and detoxification reactions, respectively. Both enzymes are polymorphic in humans and individual phenotype can be readily assessed using caffeine ingested in coffee followed by urinary metabolite analysis. N-hydroxy arylamines can then be transported through the blood where they can form protein adducts with hemoglobin or undergo renal filtration into the urinary bladder lumen where, at acidic pH, they can react covalently with urothelial DNA. Carcinogen-DNA adduct levels in human bladder are smoking-related and the C8-deoxyguanosine derivative of 4-amino-biphenyl (ABP) is a major product. Alternatively, N-hydroxy arylamines can be conjugated in the liver by glucuronyl transferases which provides a mechanism for biliary transport to the colon lumen where beta-glucuronidases can regenerate the aglycone. In the colon mucosa, acetyltransferases can further activate the N-hydroxy metabolite by O-acetylation; and persons with the rapid acetylation phenotype are known to be at higher risk for colorectal cancer. Detection of specific arylamine-DNA adducts in human colon should provide direct evidence for the role of these carcinogens in the etiology of this disease. JF - Princess Takamatsu symposia AU - Kadlubar, F F AD - National Center for Toxicological Research (HFT-100), Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 329 EP - 338 VL - 21 KW - Amines KW - 0 KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Acetyltransferases KW - EC 2.3.1.- KW - Index Medicus KW - Liver -- enzymology KW - Intestines -- enzymology KW - Humans KW - Acetyltransferases -- physiology KW - Cytochrome P-450 Enzyme System -- physiology KW - Smoking -- adverse effects KW - Liver -- metabolism KW - Intestines -- metabolism KW - Colorectal Neoplasms -- chemically induced KW - Urinary Bladder Neoplasms -- chemically induced KW - DNA Damage KW - Amines -- metabolism KW - Amines -- adverse effects KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80400790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Princess+Takamatsu+symposia&rft.atitle=Carcinogenic+aromatic+amine+metabolism+and+DNA+adduct+detection+in+humans.&rft.au=Kadlubar%2C+F+F&rft.aulast=Kadlubar&rft.aufirst=F&rft.date=1990-01-01&rft.volume=21&rft.issue=&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Princess+Takamatsu+symposia&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-28 N1 - Date created - 1992-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vibration thresholds as a function of age and diagnosis of carpal tunnel syndrome: a preliminary report. AN - 80393146; 2131268 AB - To determine if vibration thresholds vary independently with age and carpal tunnel syndrome (CTS), 61 subjects, including 27 diagnosed with carpal tunnel-induced neuropathy, and 34 non-CTS controls, ranging in age from 20 to 65 years, were tested using the Optacon, a device used to assess vibration thresholds. No statistically significant interaction was found between the age and diagnosis factors. Results did confirm the findings of previous studies that vibration thresholds increased with age and that thresholds were elevated within the CTS group, compared to the controls. These results indicate that age-adjusted norms for vibration threshold data need to be developed. Without age-adjusted norms, screening programs for CTS that rely on vibration threshold data are likely to generate high levels of false positives, particularly for workers over 40 years of age. JF - Experimental aging research AU - Winn, F J AU - Putz-Anderson, V AD - Division of Biomedical and Behavioral Sciences, National Institute for Occupational Safety and Health, Cincinnati, OH 45230. Y1 - 1990 PY - 1990 DA - 1990 SP - 221 EP - 224 VL - 16 IS - 4 SN - 0361-073X, 0361-073X KW - Index Medicus KW - Maximum Allowable Concentration KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Aging -- physiology KW - Carpal Tunnel Syndrome -- pathology KW - Vibration KW - Carpal Tunnel Syndrome -- diagnosis KW - Aging -- pathology KW - Carpal Tunnel Syndrome -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80393146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+aging+research&rft.atitle=Vibration+thresholds+as+a+function+of+age+and+diagnosis+of+carpal+tunnel+syndrome%3A+a+preliminary+report.&rft.au=Winn%2C+F+J%3BPutz-Anderson%2C+V&rft.aulast=Winn&rft.aufirst=F&rft.date=1990-01-01&rft.volume=16&rft.issue=4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Experimental+aging+research&rft.issn=0361073X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-26 N1 - Date created - 1991-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Overview on bound residue issue--regulatory aspects. AN - 80388367; 2102442 JF - Drug metabolism reviews AU - Guest, G B AU - Fitzpatrick, S C AD - Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1990 PY - 1990 DA - 1990 SP - 595 EP - 599 VL - 22 IS - 6-8 SN - 0360-2532, 0360-2532 KW - Index Medicus KW - Meat KW - Animals KW - Food Contamination KW - Drug Residues -- toxicity KW - Drug Residues -- metabolism KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80388367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Overview+on+bound+residue+issue--regulatory+aspects.&rft.au=Guest%2C+G+B%3BFitzpatrick%2C+S+C&rft.aulast=Guest&rft.aufirst=G&rft.date=1990-01-01&rft.volume=22&rft.issue=6-8&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-25 N1 - Date created - 1991-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The rat as a drug residue bioavailability model. AN - 80386987; 2102453 JF - Drug metabolism reviews AU - Gallo-Torres, H E AD - Division of Gastrointestinal and Coagulation Drug Products, FDA, HFD-180, Rockville, Maryland 20857. Y1 - 1990 PY - 1990 DA - 1990 SP - 707 EP - 751 VL - 22 IS - 6-8 SN - 0360-2532, 0360-2532 KW - Index Medicus KW - Digestion KW - Portal Vein -- metabolism KW - Animals KW - Lymphatic System -- metabolism KW - Food Contamination KW - Absorption KW - Drug Residues -- pharmacokinetics KW - Rats -- metabolism KW - Models, Biological KW - Biological Availability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80386987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=The+rat+as+a+drug+residue+bioavailability+model.&rft.au=Gallo-Torres%2C+H+E&rft.aulast=Gallo-Torres&rft.aufirst=H&rft.date=1990-01-01&rft.volume=22&rft.issue=6-8&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-25 N1 - Date created - 1991-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Overview of bound residue chemistry. AN - 80384777; 2102444 JF - Drug metabolism reviews AU - Weber, N E AD - Food & Drug Administration, Center for Veterinary Medicine, Rockville, Maryland 20857. Y1 - 1990 PY - 1990 DA - 1990 SP - 611 EP - 615 VL - 22 IS - 6-8 SN - 0360-2532, 0360-2532 KW - Index Medicus KW - Meat KW - Animals KW - Chemistry KW - Chemical Phenomena KW - Food Contamination KW - Drug Residues -- toxicity KW - Drug Residues -- chemistry KW - Drug Residues -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80384777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Overview+of+bound+residue+chemistry.&rft.au=Weber%2C+N+E&rft.aulast=Weber&rft.aufirst=N&rft.date=1990-01-01&rft.volume=22&rft.issue=6-8&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-25 N1 - Date created - 1991-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Summary of bound residue chemistry session. AN - 80383063; 2102449 JF - Drug metabolism reviews AU - Weber, N E AD - Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland 20857. Y1 - 1990 PY - 1990 DA - 1990 SP - 677 EP - 680 VL - 22 IS - 6-8 SN - 0360-2532, 0360-2532 KW - Furazolidone KW - 5J9CPU3RE0 KW - Ronidazole KW - E01R4M1063 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cysteine -- metabolism KW - Furazolidone -- toxicity KW - Ronidazole -- toxicity KW - Glutathione -- metabolism KW - Ronidazole -- metabolism KW - Furazolidone -- metabolism KW - Drug Residues -- toxicity KW - Drug Residues -- chemistry KW - Drug Residues -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80383063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Summary+of+bound+residue+chemistry+session.&rft.au=Weber%2C+N+E&rft.aulast=Weber&rft.aufirst=N&rft.date=1990-01-01&rft.volume=22&rft.issue=6-8&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-25 N1 - Date created - 1991-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal effects of a radiocontrast agent in aging spontaneously hypertensive rats. AN - 80373307; 2100715 JF - Contributions to nephrology AU - Duarte, C G AU - Ellis, S AD - Division of Cardio-Renal Drug Products, Food and Drug Administration, Rockville, Md. Y1 - 1990 PY - 1990 DA - 1990 SP - 222 EP - 228 VL - 83 SN - 0302-5144, 0302-5144 KW - Diatrizoate KW - 117-96-4 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred SHR KW - Male KW - Hypertension -- complications KW - Aging -- physiology KW - Diatrizoate -- toxicity KW - Kidney Failure, Chronic -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80373307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+nephrology&rft.atitle=Renal+effects+of+a+radiocontrast+agent+in+aging+spontaneously+hypertensive+rats.&rft.au=Duarte%2C+C+G%3BEllis%2C+S&rft.aulast=Duarte&rft.aufirst=C&rft.date=1990-01-01&rft.volume=83&rft.issue=&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Contributions+to+nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-26 N1 - Date created - 1991-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of time Ojibway adolescents spent with parents/elders in the 1930s and 1980s. AN - 80348515; 2096945 AB - This study compared quantity and quality of family time spent with parents/elders by American Indian Ojibway adolescents (ages 12-18) in the 1980s to Ojibway adults (ages 55-70) who were adolescents in the 1930s. Results indicated that 1980s adolescents spent an average of 12.5 hours per week with parents/elders compared to 62 hours per week indicated by respondents who were adolescents in the 1930s. The 1980s adolescents reported significantly more adult substance use and family abuse within their homes, and indicated significantly less favorable well-being responses than 1930s adolescents. JF - American Indian and Alaska native mental health research : journal of the National Center AU - Zitzow, D AD - PHS Indian Health Service, White Earth Clinic, Minnesota 56591. Y1 - 1990 PY - 1990 DA - 1990 SP - 7 EP - 16 VL - 3 IS - 3 SN - 0893-5394, 0893-5394 KW - Index Medicus KW - Cross-Sectional Studies KW - Alcoholism -- epidemiology KW - Humans KW - Incidence KW - Adolescent KW - Minnesota -- epidemiology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Juvenile Delinquency -- legislation & jurisprudence KW - Social Change KW - Parent-Child Relations KW - Indians, North American -- psychology KW - Juvenile Delinquency -- trends KW - Juvenile Delinquency -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80348515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Indian+and+Alaska+native+mental+health+research+%3A+journal+of+the+National+Center&rft.atitle=A+comparison+of+time+Ojibway+adolescents+spent+with+parents%2Felders+in+the+1930s+and+1980s.&rft.au=Zitzow%2C+D&rft.aulast=Zitzow&rft.aufirst=D&rft.date=1990-01-01&rft.volume=3&rft.issue=3&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=American+Indian+and+Alaska+native+mental+health+research+%3A+journal+of+the+National+Center&rft.issn=08935394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-23 N1 - Date created - 1991-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the genotoxicity of gentian violet in bacterial and mammalian cell systems. AN - 80346631; 1982909 AB - Previous studies indicate that gentian violet (GV), a triphenylmethane dye used in agriculture and human medicine, is a clastogen in vitro and a carcinogen in chronically exposed mice and rats. Data on its genotoxic activity, however, have been incomplete and partly contradictory. Mutagenesis and DNA damage experiments were conducted to re-evaluate the genotoxic potential of GV in both bacterial and mammalian cell systems. GV was mutagenic in Salmonella typhimurium tester strains TA97 and TA104, but there was little mutagenic activity detected in strains TA98 and TA100. A rat liver homogenate fraction (S9) tended to increase mutagenicity. The major microsomal metabolites of GV, pentamethylpararosaniline and N,N,N',N'-tetramethylpararosaniline were less mutagenic in TA97 and TA104, while N,N,N',N"-tetramethylpararosaniline was a weak mutagen in Salmonella. GV was not mutagenic in Chinese hamster ovary (CHO) cell strain CHO-K1-BH4, and was a questionable mutagen in CHO-AS52 cells. While GV produced DNA damage as measured by sedimentation of nucleotids derived from B6C3F1 mouse lymphocytes treated in vitro, no damage was found in lymphocytes isolated from mice dosed with GV. GV was also a weak producer of gene amplification in an SV40-transformed Chinese hamster cell line. The results indicate that GV is a point mutagen in bacteria; however, since similar exposure conditions produced weak mutagenic activity in mammalian cells, GV may be carcinogenic by virtue of its clastogenic activity. JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Aidoo, A AU - Gao, N AU - Neft, R E AU - Schol, H M AU - Hass, B S AU - Minor, T Y AU - Heflich, R H AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, Arkansas. Y1 - 1990 PY - 1990 DA - 1990 SP - 449 EP - 462 VL - 10 IS - 6 SN - 0270-3211, 0270-3211 KW - Mutagens KW - 0 KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Salmonella typhimurium -- drug effects KW - Mice KW - Lymphocytes -- drug effects KW - Cell Line KW - Gene Amplification KW - Gentian Violet -- pharmacology KW - DNA Damage KW - Microsomes, Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80346631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Evaluation+of+the+genotoxicity+of+gentian+violet+in+bacterial+and+mammalian+cell+systems.&rft.au=Aidoo%2C+A%3BGao%2C+N%3BNeft%2C+R+E%3BSchol%2C+H+M%3BHass%2C+B+S%3BMinor%2C+T+Y%3BHeflich%2C+R+H&rft.aulast=Aidoo&rft.aufirst=A&rft.date=1990-01-01&rft.volume=10&rft.issue=6&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-15 N1 - Date created - 1991-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of complex behavioral baselines to monitor residual drug effects in animals. AN - 80335413; 2092216 JF - NIDA research monograph AU - Paule, M G AD - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1990 PY - 1990 DA - 1990 SP - 57 EP - 70 VL - 101 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Animals KW - Motor Activity -- drug effects KW - Conditioning, Operant -- drug effects KW - Behavior, Animal -- drug effects KW - Drug Residues -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80335413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Use+of+complex+behavioral+baselines+to+monitor+residual+drug+effects+in+animals.&rft.au=Paule%2C+M+G&rft.aulast=Paule&rft.aufirst=M&rft.date=1990-01-01&rft.volume=101&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of caloric restriction on the maintenance of genetic fidelity. AN - 80239937; 2282043 JF - Basic life sciences AU - Hart, R W AU - Turturro, A AU - Pegram, R A AU - Chou, M W AD - National Center for Toxicological Research, United States Public Health Service, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 351 EP - 361 VL - 53 SN - 0090-5542, 0090-5542 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Temperature KW - Gene Expression KW - Energy Intake KW - DNA Repair KW - DNA Damage KW - Diet KW - Longevity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80239937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Effects+of+caloric+restriction+on+the+maintenance+of+genetic+fidelity.&rft.au=Hart%2C+R+W%3BTurturro%2C+A%3BPegram%2C+R+A%3BChou%2C+M+W&rft.aulast=Hart&rft.aufirst=R&rft.date=1990-01-01&rft.volume=53&rft.issue=&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-14 N1 - Date created - 1991-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition. AN - 80226851; 2177401 AB - Quinolone is reported to interact with caffeine, often resulting in an increase both in the plasma half-life and AUC, a decrease in total plasma clearance, and little change in the absorption rate constant and maximum plasma level. These complex changes in the pharmacokinetics of caffeine were analyzed experimentally and from published reports in order to determine the nature of the interaction, which is thought to be due to inhibition of caffeine metabolism by quinolones. A simple pharmacokinetic model for the caffeine-quinolone interaction was developed, which provides a unified method for evaluation and comparison of the effect of quinolones on the disposition of caffeine. The model is applicable to other methylxanthines, such as theophylline. The relative potency of the interactions of quinolones with caffeine in humans has been established as enoxacin (100), pipemidic acid (29), ciprofloxacin (11), norfloxacin (9) and ofloxacin (0). JF - European journal of clinical pharmacology AU - Barnett, G AU - Segura, J AU - de la Torre, R AU - Carbó, M AD - Division of Cardio-Renal Drug Products, Food and Drug Administration, Rockville. Y1 - 1990 PY - 1990 DA - 1990 SP - 63 EP - 69 VL - 39 IS - 1 SN - 0031-6970, 0031-6970 KW - Quinolones KW - 0 KW - Enoxacin KW - 325OGW249P KW - Caffeine KW - 3G6A5W338E KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Ofloxacin KW - A4P49JAZ9H KW - Pipemidic Acid KW - LT12J5HVR8 KW - Norfloxacin KW - N0F8P22L1P KW - Index Medicus KW - Ciprofloxacin -- pharmacology KW - Drug Interactions KW - Pipemidic Acid -- pharmacology KW - Ofloxacin -- pharmacology KW - Norfloxacin -- pharmacology KW - Enoxacin -- pharmacology KW - Humans KW - Models, Biological KW - Male KW - Caffeine -- pharmacokinetics KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80226851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+pharmacology&rft.atitle=Pharmacokinetic+determination+of+relative+potency+of+quinolone+inhibition+of+caffeine+disposition.&rft.au=Barnett%2C+G%3BSegura%2C+J%3Bde+la+Torre%2C+R%3BCarb%C3%B3%2C+M&rft.aulast=Barnett&rft.aufirst=G&rft.date=1990-01-01&rft.volume=39&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+pharmacology&rft.issn=00316970&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-05 N1 - Date created - 1991-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic mapping of the effects of intravenous methamphetamine administration in freely moving rats. AN - 80219218; 1980372 AB - The 2-[14C]deoxyglucose method was used to examine the effects of acute intravenous administration of methamphetamine (0.5-2.5 mg/kg) on rates of local cerebral glucose utilization in freely-moving rats. These effects were correlated with the effects of methamphetamine on locomotor activity assessed simultaneously in the same animals. Methamphetamine administration resulted in widespread dose-dependent increases in glucose utilization within structures of the extrapyramidal motor system. Rates of glucose utilization were positively correlated with locomotor activity in the globus pallidus, substantia nigra reticulata, entopeduncular nucleus, subthalamic nucleus, and the lateral cerebellar cortex. In contrast, within the limbic system alterations in metabolic activity were smaller and more selective. Glucose utilization was increased in the nucleus accumbens at all doses tested, but alterations in glucose utilization in the ventral tegmental area, amygdala, and anterior cingulate were observed only at the highest doses of methamphetamine tested. Significant increases in rates of glucose metabolism were also found in the substantia nigra compacta and in the median and dorsal raphe nuclei. Dopamine and serotonin are depleted in these regions, as well as in the ventral tegmental area where glucose utilization was also increased, following chronic treatment with high doses of methamphetamine. These changes in glucose utilization may be indicative of disturbances in the biochemical processes involved in the neurotoxic effects of methamphetamine. JF - Psychopharmacology AU - Pontieri, F E AU - Crane, A M AU - Seiden, L S AU - Kleven, M S AU - Porrino, L J AD - Laboratory of Cerebral Metabolism, National Institute of Mental Health, Public Health Service, Bethesda, MD 20892. Y1 - 1990 PY - 1990 DA - 1990 SP - 175 EP - 182 VL - 102 IS - 2 SN - 0033-3158, 0033-3158 KW - Blood Glucose KW - 0 KW - Central Nervous System Stimulants KW - Carbon Dioxide KW - 142M471B3J KW - Methamphetamine KW - 44RAL3456C KW - Deoxyglucose KW - 9G2MP84A8W KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Central Nervous System Stimulants -- pharmacology KW - Blood Glucose -- metabolism KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Autoradiography KW - Rats, Inbred Strains KW - Rats KW - Behavior, Animal -- drug effects KW - Oxygen -- blood KW - Energy Metabolism -- drug effects KW - Hematocrit KW - Blood Pressure -- drug effects KW - Carbon Dioxide -- blood KW - Male KW - Methamphetamine -- administration & dosage KW - Brain -- drug effects KW - Methamphetamine -- pharmacology KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80219218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Metabolic+mapping+of+the+effects+of+intravenous+methamphetamine+administration+in+freely+moving+rats.&rft.au=Pontieri%2C+F+E%3BCrane%2C+A+M%3BSeiden%2C+L+S%3BKleven%2C+M+S%3BPorrino%2C+L+J&rft.aulast=Pontieri&rft.aufirst=F&rft.date=1990-01-01&rft.volume=102&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-26 N1 - Date created - 1991-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of nitro-polycyclic aromatic hydrocarbons. AN - 80209851; 2272288 JF - Drug metabolism reviews AU - Fu, P P AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 209 EP - 268 VL - 22 IS - 2-3 SN - 0360-2532, 0360-2532 KW - Biphenyl Compounds KW - 0 KW - Carcinogens KW - Naphthalenes KW - Nitro Compounds KW - Polycyclic Compounds KW - 1-nitronaphthalene KW - A51NP1DL2T KW - 4-nitrobiphenyl KW - QM80NUW6WZ KW - Index Medicus KW - Naphthalenes -- metabolism KW - Animals KW - Carcinogens -- metabolism KW - Humans KW - Biphenyl Compounds -- metabolism KW - Polycyclic Compounds -- metabolism KW - Nitro Compounds -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80209851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Metabolism+of+nitro-polycyclic+aromatic+hydrocarbons.&rft.au=Fu%2C+P+P&rft.aulast=Fu&rft.aufirst=P&rft.date=1990-01-01&rft.volume=22&rft.issue=2-3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-25 N1 - Date created - 1991-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cross-sectional study of platinum salts sensitization among precious metals refinery workers. AN - 80188223; 2264564 AB - A cross-sectional medical evaluation was conducted to determine respiratory and dermatological effects of platinum salts sensitization among workers in a secondary refinery of precious metals. Fifteen of 107 current employees and eight (28%) of 29 former employees, who had been terminated from employment on average for 5 years because of respiratory symptoms, had positive skin reactivity to platinum salts. Platinum salts skin reactivity was significantly associated with average air concentrations of platinum salts in employees' present work area. Workers with positive platinum salts skin tests had significantly higher prevalences of reported rhinitis, asthma, and dermatitis than negative skin test workers. They also had increased bronchial response to cold air challenge and elevated levels of total serum IgE. Platinum salts sensitization was not associated with atopic tendency as measured by sensitivity to common aeroallergens, but was strongly associated with cigarette smoking status. The findings indicate that cigarette smoking may be a risk factor for the development of platinum salts allergy. The persistence of platinum salts sensitization and high prevalence of adverse health outcomes among former workers demonstrate the importance of regular medical monitoring so that sensitized workers can be removed from exposure before they develop long-term health problems. JF - American journal of industrial medicine AU - Baker, D B AU - Gann, P H AU - Brooks, S M AU - Gallagher, J AU - Bernstein, I L AD - National Institute for Occupational Safety and Health, New York, New York. Y1 - 1990 PY - 1990 DA - 1990 SP - 653 EP - 664 VL - 18 IS - 6 SN - 0271-3586, 0271-3586 KW - Platinum KW - 49DFR088MY KW - Index Medicus KW - Respiratory Function Tests KW - Environmental Monitoring KW - Cross-Sectional Studies KW - Animals KW - Skin Tests KW - Risk Factors KW - Humans KW - Cats KW - Smoking -- adverse effects KW - Middle Aged KW - Epidemiological Monitoring KW - Cold Temperature KW - Occupational Exposure KW - Hypersensitivity -- epidemiology KW - Platinum -- adverse effects KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80188223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Cross-sectional+study+of+platinum+salts+sensitization+among+precious+metals+refinery+workers.&rft.au=Baker%2C+D+B%3BGann%2C+P+H%3BBrooks%2C+S+M%3BGallagher%2C+J%3BBernstein%2C+I+L&rft.aulast=Baker&rft.aufirst=D&rft.date=1990-01-01&rft.volume=18&rft.issue=6&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-04 N1 - Date created - 1991-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nutritional toxicology: basic principles and actual problems. AN - 80182564; 2262017 AB - Nutritional toxicology is a specialty that combines the backgrounds and research approaches of nutrition and toxicology. Many problems of substantial importance to health and food safety involve interactions of nutrition process and requirement with the effects of toxicological impact. Solution of these problems requires research that meets the procedural and design criteria of experimental nutrition and these of experimental toxicology. The relationships may be described in three basic categories: (1) influence of nutrition on toxicities; (2) influence of toxicants on nutrition; and (3) toxicities of nutrients. Trypsin inhibitor research, an example of diet impacting on toxicological response, illustrates the necessity of controlling nutritional composition aspects that can confound the results. Prolonged acetaminophen administration provides an example of the effects of toxicants on nutritional requirement and function which could be important for persons with marginal sulphur amino acid intake. JF - Food additives and contaminants AU - Hathcock, J N AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204. Y1 - 1990 PY - 1990 DA - 1990 SP - S12 EP - S18 VL - 7 Suppl 1 SN - 0265-203X, 0265-203X KW - Index Medicus KW - Nutritional Requirements KW - Animals KW - Humans KW - Food -- adverse effects KW - Nutritional Physiological Phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80182564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Nutritional+toxicology%3A+basic+principles+and+actual+problems.&rft.au=Hathcock%2C+J+N&rft.aulast=Hathcock&rft.aufirst=J&rft.date=1990-01-01&rft.volume=7+Suppl+1&rft.issue=&rft.spage=S12&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-07 N1 - Date created - 1991-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The feasibility of using Chinese hamsters as an animal model for aneuploidy. AN - 80163638; 2253608 AB - The utility of Chinese hamsters as a test species for aneuploidy analysis was studied using four chemicals--vincristine, methyl 2-benzimidazole carbamate (MBC), nocodazole, and cyclophosphamide. Ten or more male Chinese hamsters were used per dose and bone marrow was removed at intervals of 6-96 hr. Slides were coded and 50-100 metaphases were analyzed per animal. A metaphase with more than 22 chromosomes was classified as a hyperploid cell, and the data were evaluated by using a one-tailed Fisher's exact test. In experiments using vincristine, MBC, and nocodazole, the frequencies of hyperploid cells were 0.43, 1.14, and 0.91%, respectively, for the control groups. In the experiment using cyclophosphamide, the control value frequency was 3.75%. The treated groups showed no significant increase in hyperploid frequencies when compared to concurrent controls at each of the treated times, except the value at 24 hr for the group that had been treated with vincristine at 0.75 mg/kg. However, this increase was not significant when compared to the overall value for pooled controls, with or without the cyclophosphamide control. Therefore, no significant effects due to chemical treatment were obtained in the present study. The results illustrate the extent of animal-to-animal as well as experiment-to-experiment variability in hyperploid frequencies and the importance of incorporating concurrent controls in assays for aneuploidy. JF - Environmental and molecular mutagenesis AU - Sheu, C W AU - Lee, J K AU - Arras, C A AU - Jones, R L AU - Lavappa, K S AD - Division of Toxicological Studies, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1990 PY - 1990 DA - 1990 SP - 320 EP - 323 VL - 16 IS - 4 SN - 0893-6692, 0893-6692 KW - Benzimidazoles KW - 0 KW - Carbamates KW - Mutagens KW - Vincristine KW - 5J49Q6B70F KW - Cyclophosphamide KW - 8N3DW7272P KW - carbendazim KW - H75J14AA89 KW - Nocodazole KW - SH1WY3R615 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Cricetulus KW - Disease Models, Animal KW - Bone Marrow -- metabolism KW - Nocodazole -- toxicity KW - Cyclophosphamide -- toxicity KW - Vincristine -- toxicity KW - Male KW - Benzimidazoles -- toxicity KW - Cricetinae KW - Aneuploidy KW - Models, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80163638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=The+feasibility+of+using+Chinese+hamsters+as+an+animal+model+for+aneuploidy.&rft.au=Sheu%2C+C+W%3BLee%2C+J+K%3BArras%2C+C+A%3BJones%2C+R+L%3BLavappa%2C+K+S&rft.aulast=Sheu&rft.aufirst=C&rft.date=1990-01-01&rft.volume=16&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-18 N1 - Date created - 1991-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol ester induces morphological changes and acidic fibroblast growth factor RNA expression in the RD/TE 671 cell line. AN - 80154449; 1701302 AB - The TE 671 medulloblastoma cell line was induced by phorbol-12-myristate-13-acetate (PMA) to resemble neuronal cells by both morphological and immunohistochemical criteria. Five days following PMA treatment at a concentration of 10 ng/ml, the cells acquired long cellular processes and cell growth was markedly inhibited. Immunohistochemically, PMA-treated cells stained intensely for neuron-specific enolase and were positive for neurofilaments. Northern blot analysis revealed that PMA induced the transcript for acidic fibroblast growth factor. Our data suggest that the TE 671 cell may be useful not only in the study of acidic fibroblast growth factor regulation but also as a model for embryonic tumor cell differentiation. JF - Pathobiology : journal of immunopathology, molecular and cellular biology AU - Hooper, W C AU - Zaki, S R AU - Pruckler, J AU - Garcia, J AU - Evatt, B L AD - Division of Immunologic, Oncologic and Hematologic Diseases, Centers for Disease Control, US Department of Health and Human Services, Atlanta, Ga. Y1 - 1990 PY - 1990 DA - 1990 SP - 198 EP - 203 VL - 58 IS - 4 SN - 1015-2008, 1015-2008 KW - Fibroblast Growth Factor 1 KW - 104781-85-3 KW - RNA KW - 63231-63-0 KW - Phosphopyruvate Hydratase KW - EC 4.2.1.11 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Medulloblastoma -- metabolism KW - Phosphopyruvate Hydratase -- metabolism KW - RNA -- metabolism KW - Humans KW - Rhabdomyosarcoma -- pathology KW - Rhabdomyosarcoma -- metabolism KW - Cell Division -- drug effects KW - Medulloblastoma -- pathology KW - Cell Differentiation -- drug effects KW - Cell Line KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Tumor Cells, Cultured -- pathology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Fibroblast Growth Factor 1 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80154449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathobiology+%3A+journal+of+immunopathology%2C+molecular+and+cellular+biology&rft.atitle=Phorbol+ester+induces+morphological+changes+and+acidic+fibroblast+growth+factor+RNA+expression+in+the+RD%2FTE+671+cell+line.&rft.au=Hooper%2C+W+C%3BZaki%2C+S+R%3BPruckler%2C+J%3BGarcia%2C+J%3BEvatt%2C+B+L&rft.aulast=Hooper&rft.aufirst=W&rft.date=1990-01-01&rft.volume=58&rft.issue=4&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Pathobiology+%3A+journal+of+immunopathology%2C+molecular+and+cellular+biology&rft.issn=10152008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-22 N1 - Date created - 1991-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biological monitoring of a worker acutely exposed to MBOCA. AN - 80131418; 2244630 AB - A 30 year-old male polyurethane worker was exposed to an accidental spill of 4,4'-methylene-bis-2-chloroaniline (MBOCA) at a plant producing MBOCA-cured plastic products. Exposure to MBOCA is significant in that this compound is a known animal carcinogen and a suspected human carcinogen. The employee was sprayed over his upper body and extremities with molten MBOCA while cleaning out a clogged hose from a MBOCA and polymer mixing machine. The subsequent environmental and medical evaluation of this episode included serial urinary MBOCA samples from the worker over a 2 week period to allow the calculation of a biological half-life for this compound. This worker experienced a very high dose of MBOCA as judged by his urinary MBOCA levels (peak value of 1,700 ppb 4 hours after exposure). There were no acute symptoms or other laboratory abnormalities noted. The kinetic evaluation resulted in a biological half-life for MBOCA in urine of approximately 23 hours. Assuming a one-compartment model, approximately 94% of an initial MBOCA dose will be eliminated within four days. This is the first report of kinetic analysis on urinary MBOCA excretion in humans. This information suggests that biological monitoring of the urine MBOCA concentrations in exposed workers may miss peak levels following an acute exposure unless the analyses of the urinary MBOCA are performed in a timely fashion. Recommendations to the company included: 1) installation of a warning system or lock-out device on the mixing machine to prevent the opening of the MBOCA hose prior to the release of pressure; and 2) annual medical surveillance of this individual for bladder cancer with urinalysis and urine cytology. JF - American journal of industrial medicine AU - Osorio, A M AU - Clapp, D AU - Ward, E AU - Wilson, H K AU - Cocker, J AD - NIOSH, DSHEFS, Cincinnati, OH. Y1 - 1990 PY - 1990 DA - 1990 SP - 577 EP - 589 VL - 18 IS - 5 SN - 0271-3586, 0271-3586 KW - Methylenebis(chloroaniline) KW - 3L2W5VTT2A KW - Index Medicus KW - Kidney Function Tests KW - Half-Life KW - Humans KW - Adult KW - Environmental Exposure KW - Child KW - Monitoring, Physiologic KW - Liver Function Tests KW - Chromatography, High Pressure Liquid KW - Methylenebis(chloroaniline) -- pharmacokinetics KW - Accidents, Occupational KW - Chemical Industry KW - Methylenebis(chloroaniline) -- analysis KW - Methylenebis(chloroaniline) -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80131418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Biological+monitoring+of+a+worker+acutely+exposed+to+MBOCA.&rft.au=Osorio%2C+A+M%3BClapp%2C+D%3BWard%2C+E%3BWilson%2C+H+K%3BCocker%2C+J&rft.aulast=Osorio&rft.aufirst=A&rft.date=1990-01-01&rft.volume=18&rft.issue=5&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-31 N1 - Date created - 1990-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk assessment for neurotoxic effects. AN - 80103876; 1700346 AB - Regulation of neurotoxicants is generally based on setting allowable doses (exposures) by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that hopefully account for interspecies and intraspecies differences for extrapolations of experimental results obtained in animals to humans. This procedure makes no use of estimates of risk as a function of dose or does it acknowledge any risk at the NOAEL. The purpose of this paper is to illustrate how bioassay data can be used to estimate the risk of neurotoxic effects as a function of dose. In the absence of direct measurements of neurotoxic effects, biomarkers associated with neurotoxic effects can be used as measures of toxicity. In the absence of a definition of an adverse effect, an abnormal level for a measure of toxicity can be established which occurs only in a small fraction of a population which is not exposed to the substance under investigation. Risk is defined as the proportion of a population whose levels of a measure of toxicity equal or exceeds the abnormal level of the measure under study. The procedure is illustrated using data for neurochemical, neurohistological, and behavioral effects of methylenedioxymethamphetamine (MDMA) administered to rats or monkeys. This procedure is more versatile than the NOAEL/uncertainty factor approach since it provides estimates of risk as a function of dose of a potential neurotoxic substance. JF - Neurotoxicology AU - Gaylor, D W AU - Slikker, W AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 211 EP - 218 VL - 11 IS - 2 SN - 0161-813X, 0161-813X KW - Designer Drugs KW - 0 KW - Serotonin KW - 333DO1RDJY KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Animals KW - Axons -- drug effects KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - Hydroxyindoleacetic Acid -- metabolism KW - Hippocampus -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Macaca mulatta KW - Motor Activity -- drug effects KW - Serotonin -- metabolism KW - 3,4-Methylenedioxyamphetamine -- toxicity KW - Female KW - Male KW - Designer Drugs -- toxicity KW - Risk KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80103876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Risk+assessment+for+neurotoxic+effects.&rft.au=Gaylor%2C+D+W%3BSlikker%2C+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=1990-01-01&rft.volume=11&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-07 N1 - Date created - 1990-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thallium intoxication produces neurochemical alterations in rat brain. AN - 80102292; 2172876 AB - Thallium, a rodenticide, has been shown to produce several neurological symptoms including motor weakness, ataxia, tremor, convulsion, coma and death. The present study was designed to evaluate the effects of acute or subacute exposure to thallium on several neurochemical biomarkers in rat brain. In the acute study, adult male CD rats were treated with 0 or 20 mg thallium/kg intraperitoneally (ip) and sacrificed 2, 6, or 24 hr after exposure. In the subacute study, animals were treated with 0 or 5 mg thallium/kg ip daily for 10 days and sacrificed 24 hr after the last dose. Acute injections of thallium produced in the frontal cortex significant increases in glutamine concentration after 6 hr and in taurine after 6 and 24 hr. In hippocampus, significant decreases in aspartic acid and taurine concentrations were found after 6 hr. Subacute exposure to thallium produced significant increases of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and serotonin (5-HT) in amygdala and increases in 5-HT concentration in hypothalamus. DA or muscarinic cholinergic (MCh) receptor binding did not show any significant alterations in caudate nucleus or frontal cortex after acute or subacute exposure to thallium. However, when membranes prepared from control caudate nuclei were incubated with thallium (1-100 microM) in vitro, we observed a dose-dependent decrease in DA and MCh receptor binding. These data suggest that the neurotoxicity produced by thallium exposure may be associated with changes in the concentrations of amino acids and other neurotransmitters in various regions of the rat brain. JF - Neurotoxicology AU - Ali, S F AU - Jairaj, K AU - Newport, G D AU - Lipe, G W AU - Slikker, W AD - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502. Y1 - 1990 PY - 1990 DA - 1990 SP - 381 EP - 390 VL - 11 IS - 2 SN - 0161-813X, 0161-813X KW - Amino Acids KW - 0 KW - Biogenic Monoamines KW - Receptors, Dopamine KW - Receptors, Muscarinic KW - Receptors, Neurotransmitter KW - quinuclidinyl benzilate receptor KW - Quinuclidinyl Benzilate KW - 6581-06-2 KW - Thallium KW - AD84R52XLF KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Receptors, Neurotransmitter -- metabolism KW - In Vitro Techniques KW - Amino Acids -- metabolism KW - Biogenic Monoamines -- metabolism KW - Male KW - Receptors, Muscarinic -- metabolism KW - Receptors, Dopamine -- metabolism KW - Thallium -- poisoning KW - Brain Chemistry -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80102292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Thallium+intoxication+produces+neurochemical+alterations+in+rat+brain.&rft.au=Ali%2C+S+F%3BJairaj%2C+K%3BNewport%2C+G+D%3BLipe%2C+G+W%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1990-01-01&rft.volume=11&rft.issue=2&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-07 N1 - Date created - 1990-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The importance of risk assessment to the nation's health and economy. AN - 80102221; 2234539 AB - The global marketplace is changing rapidly. Never in history has the opportunity to capture new markets with new products and new generations of products been greater. However, never has the chance of losing established markets been higher. We are failing to develop new products despite the fact that Americans have paid for the science from which the world's new technologies were developed. There are many reasons for our failure to turn scientific leads into products. One of the most obvious is that we overestimate the risk of new technologies. Present policy uses a conservatively biased risk assessment process to estimate risk. This process uses many assumptions to bridge gaps in our scientific knowledge about risk. If we wish to be competitive, we must bring safe, inexpensive new products to the marketplace faster. We must seek ways of making our policies more effective while still protecting public health. Risk assessment sets the standards for product development, product approval, and environmental release. A slight miscalculation in "safety levels" can result in tens of billions of dollars in cost added to products. These added costs have a major and direct impact on the competitiveness of U.S. products in the global marketplace where differences in consumer acceptance can be calculated in a few percentage points difference in price.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Neurotoxicology AU - Hart, R W AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502. Y1 - 1990 PY - 1990 DA - 1990 SP - 181 EP - 187 VL - 11 IS - 2 SN - 0161-813X, 0161-813X KW - Index Medicus KW - United States KW - Humans KW - Economic Competition KW - Risk KW - Environmental Health -- statistics & numerical data KW - Health Policy -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80102221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=The+importance+of+risk+assessment+to+the+nation%27s+health+and+economy.&rft.au=Hart%2C+R+W&rft.aulast=Hart&rft.aufirst=R&rft.date=1990-01-01&rft.volume=11&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-07 N1 - Date created - 1990-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of bacterial assay system for monitoring genotoxic complex mixtures in the occupational setting. AN - 80090437; 2228106 AB - Workplace environmental genotoxicity assessments, which may be carried out either by laboratory analysis or using an in-situ assay system, are potentially useful for health hazard evaluations, for industrial hygiene and biological (genetic) monitoring. Whenever possible, genotoxicity assays should be performed in conjunction with industrial hygiene studies to assess the biological activity of workplace contaminants. Efforts should continue to be made to establish a simple and reliable in-situ assay system for the detection and monitoring of genotoxic complex mixtures in the occupational setting. JF - IARC scientific publications AU - Ong, T AU - Stewart, J D AU - Whong, W Z AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888. Y1 - 1990 PY - 1990 DA - 1990 SP - 101 EP - 106 IS - 104 SN - 0300-5038, 0300-5038 KW - Carcinogens, Environmental KW - 0 KW - Mutagens KW - Index Medicus KW - Salmonella -- drug effects KW - Animals KW - Salmonella -- genetics KW - Mutagenicity Tests KW - Humans KW - Drosophila -- genetics KW - Drosophila -- drug effects KW - Occupational Diseases -- prevention & control KW - Carcinogens, Environmental -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80090437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Use+of+bacterial+assay+system+for+monitoring+genotoxic+complex+mixtures+in+the+occupational+setting.&rft.au=Ong%2C+T%3BStewart%2C+J+D%3BWhong%2C+W+Z&rft.aulast=Ong&rft.aufirst=T&rft.date=1990-01-01&rft.volume=&rft.issue=104&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-12 N1 - Date created - 1990-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stereoselective formation of a K-region dihydrodiol from phenanthrene by Streptomyces flavovirens. AN - 80067506; 2222121 AB - The metabolism of phenanthrene, a polycyclic aromatic hydrocarbon (PAH), by Streptomyces flavovirens was investigated. When grown for 72 h in tryptone yeast extract broth saturated with phenanthrene, the actinomycete oxidized 21.3% of the hydrocarbon at the K-region to form trans-9,10-dihydroxy-9,10-dihydrophenanthrene (phenanthrene trans-9,10-dihydrodiol). A trace of 9-phenanthrol was also detected. Metabolites isolated by thin-layer and high performance liquid chromatography were identified by comparing chromatographic, mass spectral, and nuclear magnetic resonance properties with those of authentic compounds. Experiments using [9-14C]phenanthrene showed that the trans-9,10-dihydrodiol had 62.8% of the radioactivity found in the metabolites. Circular dichroism spectra of the phenanthrene trans-9,10-dihydrodiol indicated that the absolute configuration of the predominant enantiomer was (-)-9S,10S, the same as that of the principal enantiomer produced by mammalian enzymes. Incubation of S. flavovirens with phenanthrene is an atmosphere of 18O2, followed by gas chromatographic/mass spectral analysis of the metabolites, indicated that one atom from molecular oxygen was incorporated into each molecule of the phenanthrene trans-9,10-dihydrodiol. Cytochrome P-450 was detected in 105,000 x g supernatants prepared from cell extracts of S. flavovirens. The results show that the oxidation of phenanthrene by S. flavovirens was both regio- and stereospecific. JF - Archives of microbiology AU - Sutherland, J B AU - Freeman, J P AU - Selby, A L AU - Fu, P P AU - Miller, D W AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 260 EP - 266 VL - 154 IS - 3 SN - 0302-8933, 0302-8933 KW - Phenanthrenes KW - 0 KW - Index Medicus KW - Oxidation-Reduction KW - Mass Spectrometry KW - Gas Chromatography-Mass Spectrometry KW - Circular Dichroism KW - Biodegradation, Environmental KW - Chromatography, High Pressure Liquid KW - Phenanthrenes -- metabolism KW - Streptomyces -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80067506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Stereoselective+formation+of+a+K-region+dihydrodiol+from+phenanthrene+by+Streptomyces+flavovirens.&rft.au=Sutherland%2C+J+B%3BFreeman%2C+J+P%3BSelby%2C+A+L%3BFu%2C+P+P%3BMiller%2C+D+W%3BCerniglia%2C+C+E&rft.aulast=Sutherland&rft.aufirst=J&rft.date=1990-01-01&rft.volume=154&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Presence of endotoxins in different agricultural environments. AN - 80064093; 2220832 AB - Gram-negative bacterial endotoxins are contaminants of dusts from agricultural products. They represent a potential health hazard for farmers working in many different processes. However, the occurrence of endotoxins has not been well characterized in the various farming operations. Therefore, two farming activities with potential for generating airborne endotoxins were studied: 1) chopping of baled corn stalks or straw for bedding in New York State, and 2) oat bin unloading in Alabama. Actual airborne endotoxin levels in dusts obtained during bedding chopper operations far exceeded [90 endotoxin units (EU)/m3] the level at which acute pulmonary function decrements occur in cotton dust-exposed individuals. Endotoxin contamination of laboratory-generated dust from an oat sample likewise exceeded these levels. This study documents the presence of potentially hazardous exposures to endotoxins in two common farm processes, which expands the knowledge of airborne endotoxin exposures on the farm. JF - American journal of industrial medicine AU - Olenchock, S A AU - May, J J AU - Pratt, D S AU - Piacitelli, L A AU - Parker, J E AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1990 PY - 1990 DA - 1990 SP - 279 EP - 284 VL - 18 IS - 3 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Endotoxins KW - Index Medicus KW - Environmental Monitoring KW - New York KW - Dust -- analysis KW - Edible Grain KW - Agriculture KW - Air Pollutants, Occupational -- analysis KW - Endotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80064093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Presence+of+endotoxins+in+different+agricultural+environments.&rft.au=Olenchock%2C+S+A%3BMay%2C+J+J%3BPratt%2C+D+S%3BPiacitelli%2C+L+A%3BParker%2C+J+E&rft.aulast=Olenchock&rft.aufirst=S&rft.date=1990-01-01&rft.volume=18&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-09 N1 - Date created - 1990-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of carcinogens and mutagens in foods in the United States. AN - 80053822; 2217399 JF - Progress in clinical and biological research AU - Prival, M J AU - Scheuplein, R J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1990 PY - 1990 DA - 1990 SP - 307 EP - 321 VL - 347 SN - 0361-7742, 0361-7742 KW - Carcinogens KW - 0 KW - Mutagens KW - Index Medicus KW - United States KW - Hot Temperature KW - Animals KW - Mutagenicity Tests KW - Humans KW - Government KW - Mutagens -- analysis KW - Food Contamination -- legislation & jurisprudence KW - Carcinogens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80053822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Regulation+of+carcinogens+and+mutagens+in+foods+in+the+United+States.&rft.au=Prival%2C+M+J%3BScheuplein%2C+R+J&rft.aulast=Prival&rft.aufirst=M&rft.date=1990-01-01&rft.volume=347&rft.issue=&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-14 N1 - Date created - 1990-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antibodies to morphine in workers exposed to opiates at a narcotics manufacturing facility and evidence for similar antibodies in heroin abusers. AN - 80043246; 2215072 AB - According to the International Narcotics Control Board, over 45,000 kg of morphine and 54,000 kg of codeine were ethically manufactured in 1986 at three facilities in the United States. Little information exists about possible adverse health effects associated with workplace exposure to opiate compounds in this industry. Because there are no specific federal standards for workplace exposure to narcotic dusts, exposure-control defaults to the nuisance dust standard (10 mg/m3, as an 8 hr time-weighted average). Narcotics manufacturing workers were evaluated for anti-morphine IgG before and 10 mo. after the implementation of an improved respiratory protection program (RPP). Significantly elevated IgG levels were measured before the improved RPP (P less than 0.005). After the improved RPP, a significant reduction was observed (P less than 0.001), suggesting that specific antibody levels could be used as biomarkers of exposure. Inhibition studies showed that the antibodies were specifically directed against morphine with some cross reactivity with morphine derivatives. Preliminary results are also shown which indicate that similar anti-morphine antibodies are present in the sera of intravenous heroin abusers. Elevated levels (P less than 0.05) of anti-morphine antibodies were detected in sera from heroin abusers, providing evidence that similar antibodies may be produced from non-occupational exposure to opiates. These finding have potentially far-reaching implications for addiction research and drug testing. JF - Life sciences AU - Biagini, R E AU - Klincewicz, S L AU - Henningsen, G M AU - MacKenzie, B A AU - Gallagher, J S AU - Bernstein, D I AU - Bernstein, I L AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control, Cincinnati, OH. Y1 - 1990 PY - 1990 DA - 1990 SP - 897 EP - 908 VL - 47 IS - 10 SN - 0024-3205, 0024-3205 KW - Immunoglobulin G KW - 0 KW - Narcotics KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Smoking KW - Antibody Specificity KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Male KW - Female KW - Cross Reactions KW - Structure-Activity Relationship KW - Heroin Dependence -- immunology KW - Occupational Exposure -- prevention & control KW - Immunoglobulin G -- analysis KW - Air Pollution -- prevention & control KW - Morphine -- chemistry KW - Narcotics -- chemical synthesis KW - Morphine -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80043246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Antibodies+to+morphine+in+workers+exposed+to+opiates+at+a+narcotics+manufacturing+facility+and+evidence+for+similar+antibodies+in+heroin+abusers.&rft.au=Biagini%2C+R+E%3BKlincewicz%2C+S+L%3BHenningsen%2C+G+M%3BMacKenzie%2C+B+A%3BGallagher%2C+J+S%3BBernstein%2C+D+I%3BBernstein%2C+I+L&rft.aulast=Biagini&rft.aufirst=R&rft.date=1990-01-01&rft.volume=47&rft.issue=10&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-15 N1 - Date created - 1990-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol esters, lipopolysaccharides and colony stimulating factor production. AN - 80003791; 2205862 JF - Progress in clinical and biological research AU - Pluznik, D H AU - Bickel, M AD - Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1990 PY - 1990 DA - 1990 SP - 205 EP - 213 VL - 352 SN - 0361-7742, 0361-7742 KW - Calcium Channel Blockers KW - 0 KW - Colony-Stimulating Factors KW - Lipopolysaccharides KW - Phorbol Esters KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Transcription, Genetic -- drug effects KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Mice KW - B-Lymphocytes -- metabolism KW - Lymphocyte Activation KW - B-Lymphocytes -- drug effects KW - T-Lymphocytes -- metabolism KW - Calcium Channel Blockers -- pharmacology KW - RNA, Messenger -- metabolism KW - Signal Transduction -- drug effects KW - T-Lymphocytes -- drug effects KW - Phorbol Esters -- pharmacology KW - Lipopolysaccharides -- pharmacology KW - Colony-Stimulating Factors -- biosynthesis KW - Gene Expression Regulation -- drug effects KW - Colony-Stimulating Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80003791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Phorbol+esters%2C+lipopolysaccharides+and+colony+stimulating+factor+production.&rft.au=Pluznik%2C+D+H%3BBickel%2C+M&rft.aulast=Pluznik&rft.aufirst=D&rft.date=1990-01-01&rft.volume=352&rft.issue=&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-19 N1 - Date created - 1990-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of carcinogenic arylamine N-oxidation phenotype in humans by analysis of caffeine urinary metabolites. AN - 79967403; 2392442 JF - Progress in clinical and biological research AU - Kadlubar, F F AU - Talaska, G AU - Butler, M A AU - Teitel, C H AU - Massengill, J P AU - Lang, N P AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 107 EP - 114 VL - 340B SN - 0361-7742, 0361-7742 KW - Isoenzymes KW - 0 KW - Xanthines KW - Caffeine KW - 3G6A5W338E KW - Uracil KW - 56HH86ZVCT KW - 1-methylxanthine KW - 7EE8WCA32U KW - 5-acetylamino-6-formylamino-3-methyluracil KW - 85438-96-6 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Theophylline KW - C137DTR5RG KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - 1,7-dimethylxanthine KW - Q3565Y41V7 KW - Index Medicus KW - Phenotype KW - Oxidation-Reduction KW - Acetylation KW - Uracil -- analogs & derivatives KW - Disease Susceptibility KW - Biotransformation KW - Humans KW - Urinary Bladder Neoplasms -- genetics KW - Xanthines -- urine KW - Arylamine N-Acetyltransferase -- metabolism KW - Uracil -- urine KW - Urinary Bladder Neoplasms -- chemically induced KW - Arylamine N-Acetyltransferase -- genetics KW - Caffeine -- metabolism KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- metabolism KW - Theophylline -- urine KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79967403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Determination+of+carcinogenic+arylamine+N-oxidation+phenotype+in+humans+by+analysis+of+caffeine+urinary+metabolites.&rft.au=Kadlubar%2C+F+F%3BTalaska%2C+G%3BButler%2C+M+A%3BTeitel%2C+C+H%3BMassengill%2C+J+P%3BLang%2C+N+P&rft.aulast=Kadlubar&rft.aufirst=F&rft.date=1990-01-01&rft.volume=340B&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-04 N1 - Date created - 1990-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - DNA adduct formation in relation to tumorigenesis in mice continuously administered 4-aminobiphenyl. AN - 79954022; 2201981 JF - Progress in clinical and biological research AU - Beland, F A AU - Fullerton, N F AU - Marques, M M AU - Melchior, W B AU - Smith, B A AU - Poirier, M C AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 81 EP - 90 VL - 340A SN - 0361-7742, 0361-7742 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - DNA, Neoplasm KW - DNA, Recombinant KW - Fluorenes KW - 4-biphenylamine KW - 16054949HJ KW - N-(deoxyguanosin-8-yl)-2-aminofluorene KW - 1D7E8EIA7K KW - N-(deoxyguanosin-8-yl)-4-aminobiphenyl KW - 86408-34-6 KW - DNA KW - 9007-49-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Animals KW - 2-Acetylaminofluorene -- toxicity KW - Sex Factors KW - DNA Mutational Analysis KW - DNA, Recombinant -- analysis KW - Escherichia coli -- genetics KW - Organ Specificity KW - Mice KW - DNA, Neoplasm -- analysis KW - Mice, Inbred BALB C KW - 2-Acetylaminofluorene -- pharmacology KW - Fluorenes -- analysis KW - Deoxyguanosine -- analysis KW - Female KW - Male KW - Deoxyguanosine -- analogs & derivatives KW - Carcinogens -- pharmacology KW - Liver Neoplasms, Experimental -- analysis KW - Aminobiphenyl Compounds -- toxicity KW - DNA Damage KW - Urinary Bladder Neoplasms -- epidemiology KW - DNA -- genetics KW - Urinary Bladder Neoplasms -- analysis KW - Carcinogens -- toxicity KW - Liver Neoplasms, Experimental -- chemically induced KW - Aminobiphenyl Compounds -- pharmacology KW - Liver Neoplasms, Experimental -- epidemiology KW - Aminobiphenyl Compounds -- analysis KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79954022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=DNA+adduct+formation+in+relation+to+tumorigenesis+in+mice+continuously+administered+4-aminobiphenyl.&rft.au=Beland%2C+F+A%3BFullerton%2C+N+F%3BMarques%2C+M+M%3BMelchior%2C+W+B%3BSmith%2C+B+A%3BPoirier%2C+M+C&rft.aulast=Beland&rft.aufirst=F&rft.date=1990-01-01&rft.volume=340A&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-27 N1 - Date created - 1990-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic activation in isolated rat hepatocytes. AN - 79901312; 1366416 AB - Hepatocytes were exposed in vitro to the hepatocarcinogen N-hydroxy-2-aminofluorene (N-OH-AAF) in order to determine the nature and repair of DNA adducts formed. N-OH-AAF formed 3 DNA adducts, N-(deoxyguanosin-8yl)-2-acetylaminofluorene (dG-C8-AAF), N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF), and 3-(deoxyguanosin-N2-yl)-2-acetylaminofluorene (dG-N2-AAF). The removal of these adducts was measured up to 38 h following cessation of exposure to N-OH-AAF. The dG-C8-AAF adduct was removed with a half-life of about 10 h, while the other two remained relatively constant throughout the incubation period. The dG-C8-AAF adduct is probably responsible for the induction of unscheduled DNA synthesis (UDS) in this model in vitro system. JF - SAAS bulletin, biochemistry and biotechnology AU - Casciano, D A AD - Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 102 EP - 106 VL - 3 SN - 1052-6781, 1052-6781 KW - Fluorenes KW - 0 KW - N-(deoxyguanosin-8-yl)acetylaminofluorene KW - 37819-60-6 KW - N-hydroxy-2-aminofluorene KW - 61M94X4V24 KW - DNA KW - 9007-49-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Deoxyguanosine KW - G9481N71RO KW - Biotechnology KW - Rats KW - Animals KW - 2-Acetylaminofluorene -- pharmacology KW - DNA Damage KW - Cells, Cultured KW - DNA -- metabolism KW - Deoxyguanosine -- pharmacology KW - DNA -- biosynthesis KW - Male KW - Deoxyguanosine -- analogs & derivatives KW - DNA -- drug effects KW - Fluorenes -- pharmacology KW - DNA Repair KW - Liver -- drug effects KW - Fluorenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79901312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAAS+bulletin%2C+biochemistry+and+biotechnology&rft.atitle=Metabolic+activation+in+isolated+rat+hepatocytes.&rft.au=Casciano%2C+D+A&rft.aulast=Casciano&rft.aufirst=D&rft.date=1990-01-01&rft.volume=3&rft.issue=&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=SAAS+bulletin%2C+biochemistry+and+biotechnology&rft.issn=10526781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-04 N1 - Date created - 1990-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Physiological methylation in carcinogenesis. AN - 79881923; 2196587 JF - Progress in clinical and biological research AU - Poirier, L A AU - Zapisek, W AU - Lyn-Cook, B AD - Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 97 EP - 112 VL - 340D SN - 0361-7742, 0361-7742 KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - DNA KW - 9007-49-2 KW - Methionine KW - AE28F7PNPL KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - DNA -- metabolism KW - Choline Deficiency -- complications KW - Methionine -- deficiency KW - S-Adenosylmethionine -- physiology KW - Liver Neoplasms -- metabolism KW - Liver Neoplasms -- etiology KW - Methylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79881923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Physiological+methylation+in+carcinogenesis.&rft.au=Poirier%2C+L+A%3BZapisek%2C+W%3BLyn-Cook%2C+B&rft.aulast=Poirier&rft.aufirst=L&rft.date=1990-01-01&rft.volume=340D&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-17 N1 - Date created - 1990-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sequence analysis of Salmonella typhimurium revertants. AN - 79879126; 2196583 JF - Progress in clinical and biological research AU - Cebula, T A AU - Koch, W H AD - Food and Drug Administration, Washington, D.C. 20204. Y1 - 1990 PY - 1990 DA - 1990 SP - 367 EP - 377 VL - 340D SN - 0361-7742, 0361-7742 KW - Histidine KW - 4QD397987E KW - Index Medicus KW - Mutagenicity Tests KW - Base Sequence KW - Histidine -- genetics KW - DNA Mutational Analysis KW - Molecular Sequence Data KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79879126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Sequence+analysis+of+Salmonella+typhimurium+revertants.&rft.au=Cebula%2C+T+A%3BKoch%2C+W+H&rft.aulast=Cebula&rft.aufirst=T&rft.date=1990-01-01&rft.volume=340D&rft.issue=&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-17 N1 - Date created - 1990-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Micronutrient safety. AN - 79849235; 2193575 JF - Annals of the New York Academy of Sciences AU - Hathcock, J N AU - Rader, J I AD - Division of Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1990 PY - 1990 DA - 1990 SP - 257 EP - 266 VL - 587 SN - 0077-8923, 0077-8923 KW - Minerals KW - 0 KW - Trace Elements KW - Vitamins KW - Index Medicus KW - Nutritional Requirements KW - Humans KW - Safety KW - Vitamins -- adverse effects KW - Trace Elements -- adverse effects KW - Minerals -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79849235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Micronutrient+safety.&rft.au=Hathcock%2C+J+N%3BRader%2C+J+I&rft.aulast=Hathcock&rft.aufirst=J&rft.date=1990-01-01&rft.volume=587&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-01 N1 - Date created - 1990-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The FDA role in contact lens development and safety. AN - 79805743; 2189684 AB - The Food and Drug Administration (FDA) exercises a multifaceted role in fulfilling its mission of enforcing the Federal Food, Drug and Cosmetic Act (Act), functioning not only as industry regulator and consumer protector, but also as scientific advisor and consumer educator regarding medical devices, drugs, foods, cosmetics, and veterinary medicine. Medical devices are regulated within the Center for Devices and Radiological Health. Contact lenses are regulated under the authority of the medical device amendments. The Center is responsible for promulgating regulations, publishing guidelines, and developing written guidance in enforcing the Act, and also for guiding manufacturers of medical devices in safe and effective product development. Other components deal with the compliance of manufacturers with the marketing of medical devices within the meaning of the Act, and through labeling requirements of the Act and consumer education and informational activities. As for contact lenses, the process of updating product development regulations and guidelines is an ongoing activity. The most recent version of the Contact Lens Guideline Document, issued in April 1988, contains two major revisions involving preclinical and clinical testing. The first redefines plastics into one materials category, thus reducing testing requirements with respect to animal toxicology studies and other preclinical areas. The second revision restricts clinical testing requirements to allow confirmatory trials in applications for new daily wear lenses. The intention was to maintain the ability of studies to detect major material or design flaws in lenses, thus boosting confidence in their performance while eliminating unnecessary trials.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Cornea AU - Lippman, R E AD - Division of Ophthalmic Devices, U.S. Food and Drug Administration, Rockville, Maryland 20850. Y1 - 1990 PY - 1990 DA - 1990 SP - S64 EP - 7; discussion S68 VL - 9 Suppl 1 SN - 0277-3740, 0277-3740 KW - Disinfectants KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - AIDS/HIV KW - United States KW - Policy Making KW - HIV -- drug effects KW - Public Health KW - Humans KW - Equipment Safety KW - Contact Lenses, Extended-Wear -- standards KW - United States Food and Drug Administration KW - Contact Lenses -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79805743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cornea&rft.atitle=The+FDA+role+in+contact+lens+development+and+safety.&rft.au=Lippman%2C+R+E&rft.aulast=Lippman&rft.aufirst=R&rft.date=1990-01-01&rft.volume=9+Suppl+1&rft.issue=&rft.spage=S64&rft.isbn=&rft.btitle=&rft.title=Cornea&rft.issn=02773740&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-09 N1 - Date created - 1990-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity, metabolism, and DNA interactions of urethane. AN - 79805181; 2190358 AB - Urethane, a known animal carcinogen, has been the subject of intensive research efforts spanning 40 years. Recent concerns have focused on the presence of urethane in a variety of fermented foods and alcoholic beverages, although no epidemiological studies or human case reports have been published. Much information is available about the mutagenesis, metabolism, and DNA interactions of urethane in experimental systems. Urethane is generally not mutagenic in bacteria although in some instances it acts as a weak mutagen. Urethane is not mutagenic in Nuerospora but is weakly mutagenic in Saccharomyces. Drosophila appear to be the only organisms that consistently give positive mutagenic results with urethane, but its mutagenicity is weak and in many cases shows no clear dose dependence. Urethane is a good clastogen in mammalian somatic cells in vivo, but it shows variable results with cells in vitro. It efficiently induces sister chromatid exchanges in a variety of cells. Mammalian spermatogenic cells are insensitive to the induction of specific locus and dominant lethal mutations by urethane. Mutational synergism has been reported to occur between ethyl methanesulfonate and urethane when administered two generations apart, and some investigators have suggested possible synergism for cancer-causing mutations in mice exposed to X-rays and urethane one generation apart. These studies are controversial and have not been confirmed. Studies on the induction of cancer-causing dominant mutations by urethane are at variance with results from extensive studies with the specific locus test in mice. Urethane studies with the unscheduled DNA synthesis assay in mouse spermatogenic cells and with the sperm abnormality test have given negative results. Urethane is rapidly and evenly distributed in the body. The rate of elimination of urethane from plasma is a saturable process and varies according to the strain and age of the animal. Recent studies have concentrations similar to those in wine, ethanol inhibits the tissue distribution of urethane in mice. These results are important because they suggest a lower carcinogenic/mutagenic risk than expected from exposure to urethane in alcoholic beverages. Although research on the metabolic activation of urethane has been extensive, no conclusive results have been obtained about its active metabolite, at one time thought to be N-hydroxyurethane. More recently, it has been postulated that urethane is activated to vinyl carbamate and that this metabolite is capable of reacting with DNA.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Toxicology and industrial health AU - Sotomayor, R E AU - Collins, T F AD - Division of Toxicological Studies, Food and Drug Administration, Washington, DC 20204. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 71 EP - 108 VL - 6 IS - 1 SN - 0748-2337, 0748-2337 KW - Mutagens KW - 0 KW - Urethane KW - 3IN71E75Z5 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Humans KW - DNA -- metabolism KW - Urethane -- metabolism KW - Urethane -- toxicity KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79805181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Mutagenicity%2C+metabolism%2C+and+DNA+interactions+of+urethane.&rft.au=Sotomayor%2C+R+E%3BCollins%2C+T+F&rft.aulast=Sotomayor&rft.aufirst=R&rft.date=1990-01-01&rft.volume=6&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-09 N1 - Date created - 1990-07-09 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Identification of okadaic acid from a Caribbean dinoflagellate, Prorocentrum concavum. AN - 79804506; 2349579 AB - Lipid-soluble toxins were isolated from a Caribbean strain of the epiphytic dinoflagellate Prorocentrum concavum Fukuyo. The major lipid-soluble toxin (LD50 = 210 +/- 15 micrograms/kg i.p. in mice) was purified by normal and reversed-phase column chromatography and characterized by 1H NMR and mass spectrometry. The toxin was identified as okadaic acid by interpretation of the spectral data. Okadaic acid was previously identified as a toxic component of the related species P. lima (Ehrenberg) Dodge. The finding of okadaic acid production in P. concavum and P. lima, abundant primary producers in the ciguatera-endemic Caribbean, suggests that the role of this toxin in the etiology of ciguatera may be more significant than previously thought. JF - Toxicon : official journal of the International Society on Toxinology AU - Dickey, R W AU - Bobzin, S C AU - Faulkner, D J AU - Bencsath, F A AU - Andrzejewski, D AD - Fishery Research Branch, Food and Drug Administration, Dauphin Island, AL 36528. Y1 - 1990 PY - 1990 DA - 1990 SP - 371 EP - 377 VL - 28 IS - 4 SN - 0041-0101, 0041-0101 KW - Ethers, Cyclic KW - 0 KW - Vasoconstrictor Agents KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Index Medicus KW - Animals KW - Mice KW - Female KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Ethers, Cyclic -- isolation & purification KW - Vasoconstrictor Agents -- isolation & purification KW - Vasoconstrictor Agents -- toxicity KW - Ethers, Cyclic -- toxicity KW - Dinoflagellida -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79804506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Identification+of+okadaic+acid+from+a+Caribbean+dinoflagellate%2C+Prorocentrum+concavum.&rft.au=Dickey%2C+R+W%3BBobzin%2C+S+C%3BFaulkner%2C+D+J%3BBencsath%2C+F+A%3BAndrzejewski%2C+D&rft.aulast=Dickey&rft.aufirst=R&rft.date=1990-01-01&rft.volume=28&rft.issue=4&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-12 N1 - Date created - 1990-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antitumor activity in skin of Skh and Sencar mice by two dietary beta-carotene formulations. AN - 79798081; 2111908 AB - There is currently a great interest in the protective potential of beta-carotene and other micronutrients against carcinogenesis. We investigated the role of beta-carotene in modifying 7,12-dimethylbenz[a]anthracene (DMBA)-initiated, 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted, two-stage skin carcinogenesis. We were interested in comparing the protective effects of two types of dietary beta-carotene, a beadlet formulation and crystalline beta-carotene, in two strains of mice (Skh:HR-1 and CR:ORL Sencar). Mice were maintained throughout the study on one of these 3% beta-carotene-fortified diets or on control diets. In Week 11 after the start of the diets, the DMBA/TPA treatment regimen was begun. The resulting skin tumors were counted weekly. In addition, serum and skin levels were monitored for beta-carotene at the time of chemical initiation and at the termination of the study. A decrease in the number of cumulative tumors in the beta-carotene-fed animals compared with the appropriate control groups was observed in both strains of mice. However, statistical evaluation of the data revealed that the decrease was significant only in Skh mice. This phenomenon might be explained by the inherent sensitivity of Sencar mice to the two-stage carcinogenesis treatment regimen. The mechanism of the protective effect found in this study is still not clear. Recent data suggest that a vitamin A pathway is not probable but that a direct 1O2 and/or radical-quenching property of the parent beta-carotene molecule may be involved. This study also demonstrates that two-stage-induced skin tumorigenesis can be modified by both types of beta-carotene-fortified diets. JF - Nutrition and cancer AU - Lambert, L A AU - Koch, W H AU - Wamer, W G AU - Kornhauser, A AD - Division of Toxicology, US Food and Drug Administration, Washington, DC 20204. Y1 - 1990 PY - 1990 DA - 1990 SP - 213 EP - 221 VL - 13 IS - 4 SN - 0163-5581, 0163-5581 KW - beta Carotene KW - 01YAE03M7J KW - Carotenoids KW - 36-88-4 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - 12-O-tetradeca-2,4,6,8-tetranoylphorbol-13-acetate KW - 64604-09-7 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Body Weight KW - Mice, Inbred Strains KW - Animals KW - Skin -- drug effects KW - Skin -- metabolism KW - Food, Fortified KW - Mice KW - Female KW - Carotenoids -- pharmacokinetics KW - Skin Neoplasms -- chemically induced KW - Carotenoids -- administration & dosage KW - Diet KW - Carotenoids -- pharmacology KW - Skin Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79798081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+cancer&rft.atitle=Antitumor+activity+in+skin+of+Skh+and+Sencar+mice+by+two+dietary+beta-carotene+formulations.&rft.au=Lambert%2C+L+A%3BKoch%2C+W+H%3BWamer%2C+W+G%3BKornhauser%2C+A&rft.aulast=Lambert&rft.aufirst=L&rft.date=1990-01-01&rft.volume=13&rft.issue=4&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+cancer&rft.issn=01635581&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-29 N1 - Date created - 1990-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Factors affecting emission collection by surgical smoke evacuators. AN - 79797700; 2345472 AB - Gaseous and particulate emissions from laser surgery are often controlled by the use of smoke evacuators. Thus it is important that factors affecting the performance of these evacuators be understood. In this study, a tracer gas technique was used to examine a number of factors affecting the performance of smoke evacuators, including evacuator flow rate, distance from the evacuator nozzle to the surgical site, and direction and speed of external air flow in relation to nozzle flow. The tracer gas technique allowed the release of emissions to be visualized with infrared imaging and also allowed the collection efficiency to be assessed quantitatively. The results were demonstrated with the use of a surgical laser system. It was found that the collection efficiency of the smoke evacuator was affected by all the factors studied. Increasing the evacuator flow rate allowed the collection of emissions under conditions in which lower evacuator flow rates had less efficient collection. The speed and direction of external air flow affected collection of emissions greatly. If the air flow was in the same direction as the nozzle flow, efficient collection of emissions at a distance from the emission release point was observed. However, at other angles relative to nozzle flow, the efficiency degraded rapidly with distance from the emission release site. With the use of the surgical laser system, at laser powers of 30 W, the tracer system predicted the collection of emissions. At 60 and 100 W of laser power, higher external air flows and greater attention to nozzle positioning were necessary. Based on the results of this study, conclusions are drawn on how to improve the collection efficiency of smoke evacuators used in laser surgery. JF - Lasers in surgery and medicine AU - Smith, J P AU - Topmiller, J L AU - Shulman, S AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1990 PY - 1990 DA - 1990 SP - 224 EP - 233 VL - 10 IS - 3 SN - 0196-8092, 0196-8092 KW - Air Pollutants KW - 0 KW - Smoke KW - Index Medicus KW - Operating Rooms KW - Gas Scavengers KW - Laser Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79797700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+surgery+and+medicine&rft.atitle=Factors+affecting+emission+collection+by+surgical+smoke+evacuators.&rft.au=Smith%2C+J+P%3BTopmiller%2C+J+L%3BShulman%2C+S&rft.aulast=Smith&rft.aufirst=J&rft.date=1990-01-01&rft.volume=10&rft.issue=3&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Lasers+in+surgery+and+medicine&rft.issn=01968092&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-05 N1 - Date created - 1990-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The American compensation phenomenon. AN - 79755146; 2139638 AB - In this article, the author defines the occupational safety and health domain, characterizes the distinct compensation phenomenon in the United States, and briefly reviews important developments in the last decade involving Karen Silkwood, intentional torts, and asbestos litigation. He examines the class conflict over the value and meaning of work-related injuries and illnesses involved in the practical activity of making claims and turning them into money through compensation inquiries. Juries, attributions of fault, and medicolegal discourse play key roles in the compensation phenomenon. This article demonstrates the extensive, probing inquiry through workers' bodies constituted by the American compensation phenomenon into the moral basis of elements of the system of production. JF - International journal of health services : planning, administration, evaluation AU - Bale, A AD - Yale Center for Mental Health Services Research, New Haven, CT 06519. Y1 - 1990 PY - 1990 DA - 1990 SP - 253 EP - 275 VL - 20 IS - 2 SN - 0020-7314, 0020-7314 KW - Index Medicus KW - United States KW - Political Systems KW - Social Class KW - Humans KW - Power (Psychology) KW - Workers' Compensation -- legislation & jurisprudence KW - Occupational Diseases -- economics KW - Workers' Compensation -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79755146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+health+services+%3A+planning%2C+administration%2C+evaluation&rft.atitle=The+American+compensation+phenomenon.&rft.au=Bale%2C+A&rft.aulast=Bale&rft.aufirst=A&rft.date=1990-01-01&rft.volume=20&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=International+journal+of+health+services+%3A+planning%2C+administration%2C+evaluation&rft.issn=00207314&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-05 N1 - Date created - 1990-06-05 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Pharmacology and toxicology of novel drug delivery systems. Regulatory issues. AN - 79708305; 2182053 AB - The lure of optimising the effect of the drug on the body (pharmacodynamics) and the body on the drug (pharmacokinetics) has produced an alternative group of products designed to achieve specialised delivery and/or disposition of drugs. A toxic drug may be used in more effective concentrations by targeting the drug to its site of action and decreasing additional systemic toxicity. Four possible regulatory situations for delivery system and drug have been identified, and generalisations regarding the non-clinical studies needed for the initiation of clinical trials and New Drug Application (NDA) have been described. Problems associated with the identification of appropriate controls have been included, and the importance of basing the choice upon a scientifically rational evaluation of the pharmacodynamic and pharmacokinetic study results emphasised, along with the significance of conducting the non-clinical evaluation using the final formulation. JF - Drug safety AU - Weissinger, J AD - Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, Maryland. Y1 - 1990 PY - 1990 DA - 1990 SP - 107 EP - 113 VL - 5 Suppl 1 SN - 0114-5916, 0114-5916 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Humans KW - Legislation, Drug KW - Pharmaceutical Preparations -- administration & dosage KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79708305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Pharmacology+and+toxicology+of+novel+drug+delivery+systems.+Regulatory+issues.&rft.au=Weissinger%2C+J&rft.aulast=Weissinger&rft.aufirst=J&rft.date=1990-01-01&rft.volume=5+Suppl+1&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of glutathione and glutathione transferases in chemical carcinogenesis. AN - 79708077; 2182291 JF - Critical reviews in biochemistry and molecular biology AU - Coles, B AU - Ketterer, B AD - Department of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1990 PY - 1990 DA - 1990 SP - 47 EP - 70 VL - 25 IS - 1 SN - 1040-9238, 1040-9238 KW - Carcinogens KW - 0 KW - Isoenzymes KW - Xenobiotics KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Neoplasms -- enzymology KW - Humans KW - Substrate Specificity KW - Carcinogens -- metabolism KW - Glutathione -- metabolism KW - Glutathione Transferase -- metabolism KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79708077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+biochemistry+and+molecular+biology&rft.atitle=The+role+of+glutathione+and+glutathione+transferases+in+chemical+carcinogenesis.&rft.au=Coles%2C+B%3BKetterer%2C+B&rft.aulast=Coles&rft.aufirst=B&rft.date=1990-01-01&rft.volume=25&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+biochemistry+and+molecular+biology&rft.issn=10409238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-11 N1 - Date created - 1990-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of intestinal microflora in the metabolic activation of 6-nitrochrysene to DNA-binding derivatives in mice. AN - 79682012; 2315936 AB - 6-Nitrochrysene has previously been shown to be a potent lung and liver carcinogen following i.p. administration to newborn mice and to be metabolically activated to DNA-binding derivatives by nitro-reduction or a combination of nitro-reduction and ring oxidation. In this study, we have examined fecal metabolites and DNA-carcinogen adducts in 5-week-old conventional and germfree Balb/c mice treated with [3H]6-nitrochrysene in order to determine if the metabolic activation pathway(s) for this compound in these mice differs from that observed in preweanling mice. We further evaluated the role of the intestinal microflora on the metabolism and generation of DNA-reactive metabolites in this system. The amount of 6-aminochrysene excreted in the feces of germfree mice within 48 h after treatment with a single i.p. dose of [3H]6-nitrochrysene (0.03 mumol/5 microliters/g body wt) was approximately 25% of that excreted in identically treated conventional mice. However, the levels of carcinogen-DNA adducts in the lungs and livers of conventional and germfree Balb/c mice were similar at the 24 and 48 h time points examined. HPLC analysis of hydrolysates of liver and lung DNA indicated that adducts derived from both N-hydroxy-6-aminochrysene and trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene metabolites were formed in the liver whereas only the latter adduct was detected in the lung. This contrasts with previous findings in preweanling mice where the adduct derived from the trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene metabolite was the single major adduct detected in both liver and lung DNA. The proportion of adducts derived from N-hydroxy-6-aminochrysene was significantly greater in the liver DNA of germfree mice than in the liver DNA of conventional mice. JF - Toxicology AU - Delclos, K B AU - Cerniglia, C E AU - Dooley, K L AU - Campbell, W L AU - Franklin, W AU - Walker, R P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079. PY - 1990 SP - 137 EP - 150 VL - 60 IS - 1-2 SN - 0300-483X, 0300-483X KW - Carcinogens KW - 0 KW - Chrysenes KW - DNA-Binding Proteins KW - Phenanthrenes KW - 6-nitrochrysene KW - 82ZK83O33Y KW - Index Medicus KW - Oxidation-Reduction KW - Feces -- analysis KW - Animals KW - Lung -- analysis KW - Inactivation, Metabolic KW - Biotransformation KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Liver -- analysis KW - Chromatography, High Pressure Liquid KW - DNA-Binding Proteins -- analysis KW - Carcinogens -- metabolism KW - Intestines -- analysis KW - Chrysenes -- pharmacokinetics KW - Carcinogens -- pharmacokinetics KW - Intestines -- metabolism KW - Chrysenes -- metabolism KW - Phenanthrenes -- pharmacokinetics KW - Intestines -- microbiology KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79682012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=The+role+of+intestinal+microflora+in+the+metabolic+activation+of+6-nitrochrysene+to+DNA-binding+derivatives+in+mice.&rft.au=Delclos%2C+K+B%3BCerniglia%2C+C+E%3BDooley%2C+K+L%3BCampbell%2C+W+L%3BFranklin%2C+W%3BWalker%2C+R+P&rft.aulast=Delclos&rft.aufirst=K&rft.date=1990-01-01&rft.volume=60&rft.issue=1-2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of a computerized postural sway measurement system for neurobehavioral toxicology. AN - 79679149; 2314356 AB - The study of standing posture has been associated with nervous system functioning for over a hundred years. Measures of human standing ability have attracted some attention as indicators of neurotoxic insult. The use of postural sway measures as subclinical indicators of toxicity has not been regularly incorporated into most neurobehavioral test batteries, but the development of microcomputer-controlled systems offers new possibilities. The mechanisms involved in controlling postural sway are discussed, as well as the various measurement techniques. In addition, studies involving the effects of some neurotoxic agents are cited. A postural sway measurement system that is noninvasive, has 1-2-minute test periods, provides immediate test results, and is relatively free of practice and motivation effects is described. Results present the normative characteristics of the sway parameters, a comparison of three data transformation techniques, and the effects of height and weight on the sway parameters. Power calculations were also performed to estimate the number of subjects needed to detect effects at both the 80% and 90% power levels. JF - Neurotoxicology and teratology AU - Dick, R B AU - Bhattacharya, A AU - Shukla, R AD - U.S. Department of Health and Human Services, Centers for Disease Control National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. PY - 1990 SP - 1 EP - 6 VL - 12 IS - 1 SN - 0892-0362, 0892-0362 KW - Index Medicus KW - Space life sciences KW - Body Weight KW - Software KW - Humans KW - Adult KW - Toxicology -- methods KW - Adolescent KW - Male KW - Female KW - Nervous System -- drug effects KW - Posture -- physiology KW - Postural Balance -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79679149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Use+of+a+computerized+postural+sway+measurement+system+for+neurobehavioral+toxicology.&rft.au=Dick%2C+R+B%3BBhattacharya%2C+A%3BShukla%2C+R&rft.aulast=Dick&rft.aufirst=R&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene. AN - 79675174; 2315340 JF - Progress in clinical and biological research AU - Beland, F A AU - Fullerton, N F AU - Kinouchi, T AU - Smith, B A AU - Poirier, M C AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 121 EP - 9; discussion 147-8 VL - 331 SN - 0361-7742, 0361-7742 KW - N-(deoxyguanosin-8-yl)acetylaminofluorene KW - 37819-60-6 KW - DNA KW - 9007-49-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Administration, Oral KW - Animals KW - Liver -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Deoxyguanosine -- analysis KW - Urinary Bladder -- analysis KW - Liver -- analysis KW - Female KW - Urinary Bladder -- drug effects KW - Deoxyguanosine -- analogs & derivatives KW - Liver Neoplasms, Experimental -- genetics KW - DNA -- isolation & purification KW - 2-Acetylaminofluorene -- administration & dosage KW - 2-Acetylaminofluorene -- toxicity KW - 2-Acetylaminofluorene -- pharmacology KW - DNA Damage KW - Urinary Bladder Neoplasms -- genetics KW - 2-Acetylaminofluorene -- analysis KW - Liver Neoplasms, Experimental -- chemically induced KW - Urinary Bladder Neoplasms -- chemically induced KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79675174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=DNA+adduct+formation+in+relation+to+tumorigenesis+in+mice+chronically+fed+2-acetylaminofluorene.&rft.au=Beland%2C+F+A%3BFullerton%2C+N+F%3BKinouchi%2C+T%3BSmith%2C+B+A%3BPoirier%2C+M+C&rft.aulast=Beland&rft.aufirst=F&rft.date=1990-01-01&rft.volume=331&rft.issue=&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-25 N1 - Date created - 1990-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Estrogen-induced thyroid follicular cell adenomas in C57BL/6 mice. AN - 79671262; 2313739 AB - Diethylstilbestrol (DES) was fed chronically to C57BL/6 mice at concentrations of 0, 5, 10, 20, 40, 160, 320, or 640 ppb in order to define the dose-response curve for neoplastic responses. The incidence of thyroid follicular cell adenomas was higher in control females than in males and was increased at mid-level doses of DES, especially in males. None were found in mice fed 640 ppb DES, probably because these mice died from other causes before follicular cell adenomas had developed. In both sexes, DES fed at 160 or 320 ppb significantly shortened time-to-onset of these tumors, and 40 ppb increased their probability late in life. It is concluded that DES has a causal relationship to thyroid neoplasia in C57BL/6 mice, and similarities between this and the human disease suggest that C57BL/6 mice may be an appropriate model for human thyroid neoplasia. JF - Journal of toxicology and environmental health AU - Greenman, D L AU - Highman, B AU - Chen, J AU - Sheldon, W AU - Gass, G AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 269 EP - 278 VL - 29 IS - 3 SN - 0098-4108, 0098-4108 KW - Estrogens KW - 0 KW - Thyrotropin KW - 9002-71-5 KW - Index Medicus KW - Pituitary Neoplasms -- chemically induced KW - Animals KW - Thyrotropin -- secretion KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Female KW - Pituitary Gland -- drug effects KW - Thyroid Neoplasms -- chemically induced KW - Adenoma -- chemically induced KW - Thyroid Neoplasms -- pathology KW - Adenoma -- pathology KW - Estrogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79671262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Estrogen-induced+thyroid+follicular+cell+adenomas+in+C57BL%2F6+mice.&rft.au=Greenman%2C+D+L%3BHighman%2C+B%3BChen%2C+J%3BSheldon%2C+W%3BGass%2C+G&rft.aulast=Greenman&rft.aufirst=D&rft.date=1990-01-01&rft.volume=29&rft.issue=3&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-23 N1 - Date created - 1990-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Irreversible loss of [3H]forskolin binding sites in human platelets by alpha-haloacetyl analogs of forskolin. AN - 79606532; 2153911 AB - The 7-bromoacetyl-7-desacetyl (BrAcFsk) and 7-chloroacetyl-7-desacetyl (CIAcFsk) analogs of forskolin were synthesized as alkylating agents to study the high affinity binding sites for forskolin. BrAcFsk and CIAcFsk activated adenylate cyclase in human platelet membranes with EC50 values of about 20 and 12 microM, respectively. Both analogs increased cyclic AMP in human platelets; however, they were less potent that forskolin. Forskolin inhibited [3H]forskolin binding to human platelet membranes with an IC50 of 20 nM, whereas BrAcFsk and CIAcFsk inhibited [3H] forskolin binding with IC50 values of 0.1 microM. Pretreatment of intact platelets with 10 microM BrAcFsk caused a 90% irreversible loss in [3H]forskolin binding sites, whereas pretreatment with 10 microM CIAcFsk led to a loss of 55% of the binding sites. The loss of binding sites occurred within 5 min for BrAcFsk and within 30 min for CIAcFsk. The time required for the loss of binding sites produced by either alkylating agent was increased by the inclusion of 200 microM forskolin in the pretreatment buffer. The inactive bromoacetyl analog of forskolin 7-bromoacetyl-7-desacetyl-1.9-dideoxyforskolin (1,9-dideoxy-BrAcFsk) did not activate adenylate cyclase, inhibit [3H]forskolin binding, or cause an irreversible loss of [3H]forskolin binding sites. Adenylate cyclase was assayed in membranes from platelets treated with either 10 microM BrAcFsk or 10 microM 1,9-dideoxy-BrAcFsk. The stimulation of adenylate cyclase by prostaglandin E1, guanosine-5'-O-(3-thio)triphosphate, and AIF4 was inhibited by about 50% in membranes from platelets treated with BrAcFsk. However, the stimulation of adenylate cyclase by forskolin was unaffected by preincubation with BrAcFsk. Pretreatment of human platelets with 1,9-dideoxy-BrAcFsk had no effect on the stimulation of adenylate cyclase by prostaglandin E1, AIF4, or forskolin. JF - Molecular pharmacology AU - Laurenza, A AU - Morris, D AU - Seamon, K B AD - Laboratory of Molecular Pharmacology, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 69 EP - 74 VL - 37 IS - 1 SN - 0026-895X, 0026-895X KW - Alkylating Agents KW - 0 KW - Aluminum Compounds KW - Colforsin KW - 1F7A44V6OU KW - tetrafluoroaluminate KW - 21340-02-3 KW - Fluorine KW - 284SYP0193 KW - Aluminum KW - CPD4NFA903 KW - Cyclic AMP KW - E0399OZS9N KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Alprostadil KW - F5TD010360 KW - Fluorides KW - Q80VPU408O KW - Index Medicus KW - Alprostadil -- pharmacology KW - Humans KW - Aluminum -- pharmacology KW - In Vitro Techniques KW - Fluorine -- pharmacology KW - Enzyme Activation -- drug effects KW - Cyclic AMP -- metabolism KW - Cell Membrane -- metabolism KW - Colforsin -- analogs & derivatives KW - Adenylyl Cyclases -- metabolism KW - Blood Platelets -- metabolism KW - Colforsin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79606532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Irreversible+loss+of+%5B3H%5Dforskolin+binding+sites+in+human+platelets+by+alpha-haloacetyl+analogs+of+forskolin.&rft.au=Laurenza%2C+A%3BMorris%2C+D%3BSeamon%2C+K+B&rft.aulast=Laurenza&rft.aufirst=A&rft.date=1990-01-01&rft.volume=37&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-23 N1 - Date created - 1990-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of interleukin-2 on cell proliferation, sister-chromatid exchange induction, and nuclear stress protein phosphorylation in PHA-stimulated Fischer 344 rat spleen lymphocytes: modulation by 2-mercaptoethanol. AN - 79597779; 2298197 AB - The effect of interleukin-2 (IL-2) on cell proliferation, sister-chromatid exchange (SCE) frequency, and the phosphorylation of nuclear stress proteins was evaluated in phytohemagglutinin (PHA)-stimulated spleen lymphocytes isolated from Fischer 344 rats. In addition, the ability of 2-mercaptoethanol (2-ME) to modulate the induction of these biological responses was characterized. Cell proliferation, as measured by the mitotic index, increased significantly (P less than .003) from a range of 3-4% in PHA-stimulated cultures to a range of 8-11% in PHA-stimulated cultures exposed to IL-2. The average generation time (AGT) did not respond to IL-2 in a concentration-dependent manner and decreased significantly (P less than .05) when 20 microM 2-ME was included with IL-2 in the culture medium. The number of SCE increased significantly (P less than .004) from control frequencies, which ranged from 13.1 to 15.6 SCE per cell, to frequencies of 18.5 to 21.5 SCE per cell as the concentration of IL-2 in the culture medium increased to 50 half-maximal units per ml. A reduction in SCE frequency was observed when cells were cultured with 20 microM 2-ME and IL-2 compared to IL-2 alone. Three nuclear proteins, with relative molecular masses of approximately 13,000-18,000, 20,000, and 80,000, were phosphorylated in IL-2-exposed G1-phase nuclei. Elicitation of these nuclear proteins in IL-2-exposed cells was not affected by exposure to 2-ME. JF - Environmental and molecular mutagenesis AU - Morris, S M AU - Aidoo, A AU - Domon, O E AU - McGarrity, L J AU - Kodell, R L AU - Schol, H M AU - Hinson, W G AU - Pipkin, J L AU - Casciano, D A AD - Division of Genetic Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1990 PY - 1990 DA - 1990 SP - 10 EP - 18 VL - 15 IS - 1 SN - 0893-6692, 0893-6692 KW - Heat-Shock Proteins KW - 0 KW - Interleukin-2 KW - Nuclear Proteins KW - Phytohemagglutinins KW - Mercaptoethanol KW - 60-24-2 KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Animals KW - Drug Interactions KW - Spleen -- cytology KW - Mitotic Index -- drug effects KW - Cell Division -- drug effects KW - Phytohemagglutinins -- pharmacology KW - Rats KW - Rats, Inbred F344 KW - Heat-Shock Proteins -- drug effects KW - Phosphorylation KW - Sister Chromatid Exchange -- drug effects KW - In Vitro Techniques KW - Data Interpretation, Statistical KW - Nuclear Proteins -- drug effects KW - Spleen -- drug effects KW - Nuclear Proteins -- metabolism KW - Male KW - Interleukin-2 -- pharmacology KW - Mercaptoethanol -- pharmacology KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79597779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Effect+of+interleukin-2+on+cell+proliferation%2C+sister-chromatid+exchange+induction%2C+and+nuclear+stress+protein+phosphorylation+in+PHA-stimulated+Fischer+344+rat+spleen+lymphocytes%3A+modulation+by+2-mercaptoethanol.&rft.au=Morris%2C+S+M%3BAidoo%2C+A%3BDomon%2C+O+E%3BMcGarrity%2C+L+J%3BKodell%2C+R+L%3BSchol%2C+H+M%3BHinson%2C+W+G%3BPipkin%2C+J+L%3BCasciano%2C+D+A&rft.aulast=Morris&rft.aufirst=S&rft.date=1990-01-01&rft.volume=15&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-23 N1 - Date created - 1990-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Botulism: north to Alaska. AN - 79588132; 2297011 JF - The American journal of nursing AU - Lancaster, M J AD - Indian Health Service, Alaska Area Native Health Service, Anchorage. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 60 EP - 62 VL - 90 IS - 1 SN - 0002-936X, 0002-936X KW - Botulinum Antitoxin KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Humans KW - Food Contamination KW - Emergencies KW - Botulinum Antitoxin -- administration & dosage KW - Alaska KW - Botulism -- etiology KW - Botulism -- therapy KW - Botulism -- nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79588132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Botulism%3A+north+to+Alaska.&rft.au=Lancaster%2C+M+J&rft.aulast=Lancaster&rft.aufirst=M&rft.date=1990-01-01&rft.volume=90&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-22 N1 - Date created - 1990-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - GEN T1 - Bibliography of Health Issues Affecting North American Indians, Eskimos, and Aleuts: 1950-1988. AN - 62829055; ED357923 AB - This bibliography of 2,414 journal articles provides health professionals and others with quick references on health and related issues of American Indians and Alaska Natives. The citations cover articles published in U.S. and Canadian medical and health-related journals between 1950 and 1988. Five sections deal with major health categories and are divided into further subcategories. The first section, "Social and Cross-Cultural Aspects of Health and Disease," covers traditional health practices; archeology, demography, and anthropology; food, nutrition, and related disorders; pregnancy, family planning, and related problems; health and disease in infancy and childhood; aging (including geriatric programs); and psychology and acculturation. The next section, "Health, Health Education, and Health Care Delivery" includes general aspects of health and disease, health and dental care delivery, Indian Health Service, education and training of health care professionals, alcohol prevention and treatment programs, and education (particularly health education and special education). The "Genetics and Metabolism" section covers metabolism, serology, blood and blood groups, dentition, congenital anomalies, and HLA-antigens. The section on "Infectious Diseases" covers the gastrointestinal tract, parasitic infestations, liver and gallbladder infections, tuberculosis, the genito-urinary tract, respiratory infections, and ear and dental problems. Finally, topics in the last section, "Noninfectious and Chronic Health Problems," concern diabetes, hypertension and heart disease, alcoholism and substance abuse, mental health problems, intentional and unintentional injuries (including suicide), neoplasms, obesity, musculoskeletal diseases and disorders, child abuse and neglect, ophthalmology, and ear diseases and hearing disorders. An author index is included. (SV) AU - Owens, Mitchell V. Y1 - 1990 PY - 1990 DA - 1990 SP - 275 KW - Native Americans KW - ERIC, Resources in Education (RIE) KW - Health Programs KW - Delivery Systems KW - Elementary Secondary Education KW - Higher Education KW - Health KW - Canada Natives KW - Health Education KW - Nutrition KW - American Indians KW - Medical Education KW - Health Services KW - Medicine KW - American Indian Education KW - Diseases KW - Alaska Natives KW - Health Programs KW - Delivery Systems KW - Elementary Secondary Education KW - Higher Education KW - Health KW - Canada Natives KW - Health Education KW - Nutrition KW - American Indians KW - Medical Education KW - Health Services KW - Medicine KW - American Indian Education KW - Diseases KW - Alaska Natives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62829055?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - The Middle Years: Career Stage Differences AN - 61641320; 199101136 AB - An occupational stress perspective is taken to analyze career stages -- specifically, relationships among job demands, career stages, & health-related strains -- for a sample of 6,000+ US postal workers. Results suggest that for middle-career-stage individuals, job stressors lose some of their potency in affecting physical health status, while stressful events outside of the job domain become increasingly deleterious. Moreover, the beneficial effects of social support on mental health vary by career stage, being most pronounced among middle-career workers. Findings emphasize the necessity for stress researchers to consider career stress effects. 4 Tables, 4 Figures, 24 References. Adapted from the source document. JF - Prevention in Human Services AU - Hurrell, Joseph J, Jr AU - McLaney, Margaret Anne AU - Murphy, Lawrence R AD - Motivation & Stress Research Section NIOSH, 4676 Columbia Pkwy Cincinnati OH 45226 Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 179 EP - 203 VL - 8 IS - 1 SN - 0270-3114, 0270-3114 KW - health status, middle-career-stage postal workers, US KW - job stressors KW - survey data KW - Public Officials KW - Family Work Relationship KW - Occupational Stress KW - United States of America KW - Health KW - Middle Aged Adults KW - article KW - 6145: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61641320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prevention+in+Human+Services&rft.atitle=The+Middle+Years%3A+Career+Stage+Differences&rft.au=Hurrell%2C+Joseph+J%2C+Jr%3BMcLaney%2C+Margaret+Anne%3BMurphy%2C+Lawrence+R&rft.aulast=Hurrell&rft.aufirst=Joseph&rft.date=1990-01-01&rft.volume=8&rft.issue=1&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Prevention+in+Human+Services&rft.issn=02703114&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health; United States of America; Occupational Stress; Middle Aged Adults; Family Work Relationship; Public Officials ER - TY - BOOK T1 - Indian Health Service: regional differences in Indian health, 1990 AN - 59565520; 1991-0208203 AB - The IHS program and the health status of American Indians and Alaska natives; includes data, 1955-88; US. JF - Washington, DC 20201, 1990. x+74 pp. Y1 - 1990///0, PY - 1990 DA - 0, 1990 EP - x+74 PB - Washington, DC 20201 KW - Alaska -- Native races -- Health KW - United States -- Health policy KW - Indians -- Health KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59565520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=x%2B74&rft.isbn=&rft.btitle=Indian+Health+Service%3A+regional+differences+in+Indian+health%2C+1990&rft.title=Indian+Health+Service%3A+regional+differences+in+Indian+health%2C+1990&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20201 pa N1 - Document feature - table(s), chart(s), map(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Healthy people 2000: national health promotion and disease prevention objectives; full report, with commentary T2 - Dept. of Health and Human Services. DHHS pubn. no. (PHS) 91-50212 AN - 59555854; 1991-0810589 AB - Addresses health protection, preventive services, surveillance and data systems, age-related objectives, and special population objectives. JF - Supt Docs, 1990. 692 pp. Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 692 PB - Supt Docs KW - Public health -- United States KW - Medicine, Preventive -- United States KW - United States -- Health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59555854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Healthy+people+2000%3A+national+health+promotion+and+disease+prevention+objectives%3B+full+report%2C+with+commentary&rft.title=Healthy+people+2000%3A+national+health+promotion+and+disease+prevention+objectives%3B+full+report%2C+with+commentary&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Supt Docs pa $9; elsewhere $11.25 N1 - Document feature - table(s), chart(s), index(es) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Health information resources in the federal government AN - 59551732; 1991-0703520 AB - Selected federal and federally sponsored agencies, offices, and programs, their services, databases, publications, and service focus; US. JF - Room 2132, Switzer Bldg., 330 C St., S.W., Washington, DC 20201, 1990. iii+61 pp. Y1 - 1990///0, PY - 1990 DA - 0, 1990 EP - iii+61 PB - Room 2132, Switzer Bldg., 330 C St., S.W., Washington, DC 20201 KW - United States -- Executive departments -- Information services KW - Public health education -- Information services KW - Public health education -- United States KW - Government information -- United States KW - Data base systems -- United States KW - United States -- Health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59551732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=iii%2B61&rft.isbn=&rft.btitle=Health+information+resources+in+the+federal+government&rft.title=Health+information+resources+in+the+federal+government&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 2132, Switzer Bldg., 330 C St., S.W., Washington, DC 20201 pa N1 - Document feature - index(es) N1 - SuppNotes - 5th ed N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Health insurance of minorities in the United States T2 - OM90-0083 AN - 59547047; 1991-0403625 AB - Changes between 1977 and 1987. Reprinted from the Journal of Health Care for the Poor and Underserved, Summer 1990. JF - Room 18-12, Parklawn Bldg., Rockville, MD 20857, 1990. 16 pp. AU - Short, Pamela Farley Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 16 PB - Room 18-12, Parklawn Bldg., Rockville, MD 20857 KW - United States -- Social policy KW - Minorities -- Medical care KW - Health insurance -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59547047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Short%2C+Pamela+Farley&rft.aulast=Short&rft.aufirst=Pamela&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+insurance+of+minorities+in+the+United+States&rft.title=Health+insurance+of+minorities+in+the+United+States&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., Rockville, MD 20857 N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - The elderly population with chronic functional disability: implications for home care eligibility T2 - OM90-0088 AN - 59546920; 1991-0403562 AB - Estimates the number of elderly persons living in the community who would be eligible for publicly or privately financed home care benefits under alternative disability criteria. Reprinted from the Gerontologist no. 4, 1990. JF - Room 18-12, Parklawn Bldg., Rockville, MD 20857, 1990. 6 pp. AU - Stone, Robyn I AU - Murtaugh, Christopher M Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 6 PB - Room 18-12, Parklawn Bldg., Rockville, MD 20857 KW - Chronically ill -- Home care KW - United States -- Social policy KW - Old age -- Home care KW - Health insurance -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59546920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stone%2C+Robyn+I%3BMurtaugh%2C+Christopher+M&rft.aulast=Stone&rft.aufirst=Robyn&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+elderly+population+with+chronic+functional+disability%3A+implications+for+home+care+eligibility&rft.title=The+elderly+population+with+chronic+functional+disability%3A+implications+for+home+care+eligibility&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 18-12, Parklawn Bldg., Rockville, MD 20857 N1 - Document feature - bibl(s), table(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Analytical Methodology for Radium in Food and Water AN - 19102736; 9103379 AB - The hazards associated with radium-226 and radium-228 have been well studied and documented. Analysis at the levels set by the Environmental Protection Agency (EPA) for these two isotopes in drinking water should present no analytical problems. The methods for radium-226 by total radium and emanation have been collaboratively studied and published in the ALPHA Standard Methods. The method of Krieger for radium-228, although it has not been collaboratively tested, has the tentative approval of the American Public Health Association (ALPHA) Standard Methods and was recommended by the National Institute for Science and Technology (formerly the National Bureau of Standards). In this method the radium is precipitated using barium and lead carriers , then purified and the actinium-228 allowed to ingrow. It is separated using a yttrium carrier and the actinium-228 is beta counted. Other methods could also be used. It should be noted that the EPA 's Quality Assurance Program should be used to document that the methods being used are performing adequately. (See also W91-03366) (Agostine-PTT) JF - Radon, Radium and Uranium in Drinking Water. Lewis Publishers, Inc., Chelsea, Michigan. 1990. p 203-212. 3 tab, 42 ref. AU - Baratta, E J AD - Food and Drug Administration Y1 - 1990 PY - 1990 DA - 1990 KW - Water Resources Abstracts KW - Analytical methods Analytical techniques Chemical analysis KW - Drinking water Foods Pollutant identification Radiochemical KW - analysis Radium Water analysis Laboratory methods Quality KW - control Radioisotopes Water quality standards KW - SW 5040:Data acquisition KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19102736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Analytical+Methodology+for+Radium+in+Food+and+Water&rft.au=Baratta%2C+E+J&rft.aulast=Baratta&rft.aufirst=E&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Analysis of spontaneous and psoralen-induced Salmonella typhimurium hisG46 revertants by oligodeoxyribonucleotide colony hybridization: Use of psoralens to cross-link probes to target sequences AN - 16813524; 3758908 AB - An improved DNA colony-hybridization method for the rapid characterization of Salmonella typhimurium hisG46 revertants is described. Oligodeoxyribonucleotides (15-mers) complementary to each of 6 possible transition or transversion mutations and an extragenic suppressor mutation, underlying the His super(+) phenotype, were prepared. Optimal sequence discrimination was achieved by hybridizing 15-mers at the apparent dissociation temperature (T sub(d)) for 2 h with chromosomal DNA of revertant colonies affixed to Whatman 541 filters. Subsequent exposure of filters to UVA radiation (320-400 nm) in the presence of 4'-hydroxymethyl-4,5',8-trimethylpsoralen (HMT) resulted in cross-linking of perfectly matched probes and target DNA sequences while sequences containing a single base-pair mismatch could be discriminated with a brief denaturing wash. No false negative results were obtained with the new procedure. An analysis of 204 spontaneous and 174 PUVA-induced TA100 revertants is presented. (DBO) JF - Mutation Research AU - Cebula, T A AU - Koch, W H AD - Mol. Biol. Branch, HFF-235, Div. Microbiol., Cent. Food Saf. and Appl. Nutr., FDA, 200 C St. S.W., Washington, DC 20204 USA Y1 - 1990 PY - 1990 DA - 1990 SP - 79 EP - 87 VL - 229 IS - 1 SN - 0027-5107, 0027-5107 KW - oligodeoxyribonucleotides KW - psoralen KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - induction KW - cross-linked KW - analysis KW - Salmonella typhimurium KW - probes KW - colonies KW - hybridization KW - revertants KW - J 02725:DNA KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16813524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Analysis+of+spontaneous+and+psoralen-induced+Salmonella+typhimurium+hisG46+revertants+by+oligodeoxyribonucleotide+colony+hybridization%3A+Use+of+psoralens+to+cross-link+probes+to+target+sequences&rft.au=Cebula%2C+T+A%3BKoch%2C+W+H&rft.aulast=Cebula&rft.aufirst=T&rft.date=1990-01-01&rft.volume=229&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella typhimurium; colonies; hybridization; analysis; induction; revertants; cross-linked; probes ER - TY - JOUR T1 - Development of a cell culture assay for Bordetella parapertussis heat-labile toxin. AN - 16665451; 3023284 AB - A cell culture assay for heat-labile toxin isolated from Bordetella parapertussis has been developed. In this assay, the ability of heat-labile toxin to induce contraction of vascular smooth muscle cells is measured. The method allows for detection of as little as 0.6 ng/ml of the toxin. The results obtained from this in vitro assay correlated well with those obtained with in vivo assays indicating that the cell culture assay may be a useful alternative to animal assays. JF - Biologicals AU - Endoh, M AU - Nagai, M AU - Burns, D L AU - Manclark, C R AU - Nakase, Y AD - Pertussis Lab., Div. Bact. Products, Cent. Biol. Eval. and Res., FDA, 8800 Rockville Pk., Bethesda, MD 20892, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 309 EP - 313 VL - 18 IS - 4 SN - 1045-1056, 1045-1056 KW - assay KW - Microbiology Abstracts B: Bacteriology KW - cell culture KW - contraction KW - smooth muscle KW - toxins KW - Bordetella parapertussis KW - in vitro KW - J 02821:Assays UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16665451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Development+of+a+cell+culture+assay+for+Bordetella+parapertussis+heat-labile+toxin.&rft.au=Endoh%2C+M%3BNagai%2C+M%3BBurns%2C+D+L%3BManclark%2C+C+R%3BNakase%2C+Y&rft.aulast=Endoh&rft.aufirst=M&rft.date=1990-01-01&rft.volume=18&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bordetella parapertussis; toxins; in vitro; cell culture; smooth muscle; contraction ER - TY - JOUR T1 - Occupational and other exposures associated with male end-stage renal disease: A case/control study. AN - 16327751; 2840161 AB - We conducted a case-control study of 325 men ages 30-60 who were diagnosed with end-stage renal disease (ESRD) between 1976 and 1984, and resided in four urban areas of Michigan in 1984. Risk of ESRD was significantly related to phenacetin or acetaminophen consumption, moonshine consumption, a family history of renal disease; and regular occupational exposures to solvents. Particular occupational exposures with elevated risk were solvents used as cleaning agents and degreasers (OR = 2.50) silica exposure in foundries or brick factories, and silica exposure during sandblasting. Little or no trend of increased risk with duration of exposure was found for these occupational exposures, with the exception of silica in sandblasting. Limitation of these data include representativeness of cases, possible overreporting by cases, and misclassification of exposures inherent in self-reports. JF - American Journal of Public Health AU - Steenland, N K AU - Thun, MJ AU - Ferguson, C W AU - Port, F K AD - NIOSH, R13, Robert A. Taft Lab., 4676 Columbia Pkwy., Cincinnati, OH 45226-1998, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 153 EP - 159 VL - 80 IS - 2 SN - 0090-0036, 0090-0036 KW - end-stage renal disease KW - Toxicology Abstracts KW - kidney KW - occupational exposure KW - man KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16327751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Occupational+and+other+exposures+associated+with+male+end-stage+renal+disease%3A+A+case%2Fcontrol+study.&rft.au=Steenland%2C+N+K%3BThun%2C+MJ%3BFerguson%2C+C+W%3BPort%2C+F+K&rft.aulast=Steenland&rft.aufirst=N&rft.date=1990-01-01&rft.volume=80&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational exposure; man; kidney ER - TY - JOUR T1 - Chloracne associated with employment in the production of pentachlorophenol. AN - 16248026; 2772910 AB - To evaluate the association between exposure to pentachlorophenol (PCP) and the occurrence of chloracne, we studied the medical and personnel records for individuals employed in the manufacturing of PCP. Forty-seven cases of chloracne were identified among 648 workers (7.0%) assigned to PCP production at a single plant between 1953 and 1978. The annual incidence rate varied considerably, ranging from 0 (in 1953) to 1.46 (in 1978). No linear trend in the risk of chloracne was observed with the duration of employment in the pentachlorophenol department. Workers with a documented episode of direct skin contact with PCP had a significantly increased risk of chloracne compared with workers who did not have a documented episode of direct skin contact. Our results confirm that chloracne is associated with exposure to PCP contaminated with hexachlorinated, heptachlorinated, and octachlorinated dibenzo-p-dioxins and dibenzofurans. JF - American Journal of Industrial Medicine AU - O'Malley, MA AU - Carpenter, A V AU - Sweeney, M H AU - Fingerhut, MA AU - Marlow, DA AU - Halperin, W E AU - Mathias, C G AD - Industrywide Stud. Branch, Div. Surv., Hazard Eval., and Field Stud., NIOSH, Mail Stop R-15, Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 411 EP - 421 VL - 17 IS - 4 SN - 0271-3586, 0271-3586 KW - pentachlorophenol KW - Toxicology Abstracts KW - occupational hazards KW - chloracne KW - production KW - man KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16248026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Chloracne+associated+with+employment+in+the+production+of+pentachlorophenol.&rft.au=O%27Malley%2C+MA%3BCarpenter%2C+A+V%3BSweeney%2C+M+H%3BFingerhut%2C+MA%3BMarlow%2C+DA%3BHalperin%2C+W+E%3BMathias%2C+C+G&rft.aulast=O%27Malley&rft.aufirst=MA&rft.date=1990-01-01&rft.volume=17&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational hazards; production; chloracne; man ER - TY - BOOK T1 - Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. AN - 16108103; 2662711 AB - Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 Parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposures (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p < .0001). JF - Chemosphere. 1990. AU - Sweeney, M H AU - Fingerhut, MA AU - Patterson, DG Jr AU - Connally, L B AU - Piacitelli, LA A2 - Birmingham, B A2 - Gilman, A A2 - Clement, R A2 - Tashiro, C (eds) Y1 - 1990 PY - 1990 DA - 1990 KW - TCDD KW - serum levels KW - chemicals KW - man KW - chemical industry KW - Pollution Abstracts; Toxicology Abstracts KW - industries KW - occupational exposure KW - X 24153:Metabolism KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16108103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sweeney%2C+M+H%3BFingerhut%2C+MA%3BPatterson%2C+DG+Jr%3BConnally%2C+L+B%3BPiacitelli%2C+LA&rft.aulast=Sweeney&rft.aufirst=M&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Comparison+of+serum+levels+of+2%2C3%2C7%2C8-TCDD+in+TCP+production+workers+and+in+an+unexposed+comparison+group.&rft.title=Comparison+of+serum+levels+of+2%2C3%2C7%2C8-TCDD+in+TCP+production+workers+and+in+an+unexposed+comparison+group.&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - BOOK T1 - Hazard and operability study of an ethylene oxide sterilizer. AN - 16066833; 2631350 AB - As a follow-up to a previous industrial hygiene study, NIOSH researchers have conducted a hazard and operability study (HAZOP), a form of process hazard analysis, on a EtO sterilizer supplied by compressed-gas cylinders. Technical representatives from the sterilizer manufacturer, a facilities person from the specific hospital that was studied, and a HAZOP team leader (hired as a consultant) also participated in the study. The sterilizer installation, equipment, and operational procedures were reviewed, and recommendations were developed both for the specific facility and for the generic installation of this type of sterilizer. The recommendations addressed sterilizer facility design, sterilizer equipment design, leak monitoring, system utilities, equipment maintenance, and operational procedures. AU - Gressel, M G AU - Gideon, JA AU - O'Brien, D M Y1 - 1990 PY - 1990 DA - 1990 SP - 1 EP - 47 KW - hazards KW - ethylene oxide KW - sterilizers KW - Health & Safety Science Abstracts KW - occupational safety KW - occupational health KW - H SI0.3:HAZARD DETERMINATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16066833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gressel%2C+M+G%3BGideon%2C+JA%3BO%27Brien%2C+D+M&rft.aulast=Gressel&rft.aufirst=M&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=Hazard+and+operability+study+of+an+ethylene+oxide+sterilizer.&rft.title=Hazard+and+operability+study+of+an+ethylene+oxide+sterilizer.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - BOOK T1 - Botanic garden horticultural worker exposure to pesticides. AN - 16066789; 2631338 AB - An evaluation of exposure to a variety of pesticides of horticultural workers at a large botanic garden facility was conducted. Air samples were collected during the application of these pesticides to document potential personal exposure, and for a period of time following application to assess reentry criteria. Surface-wipe samples were collected to assess amounts of residue remaining after application available for skin absorption. The application of pesticides and fungicides is seasonal and cyclical due to the life cycles of fungi and pests, and their adaptability to some toxins. Therefore a variety of different compounds are used during the course of a year. AU - Crandall AU - Reh, C M Y1 - 1990 PY - 1990 DA - 1990 SP - 1 EP - 15 KW - sampling KW - Health & Safety Science Abstracts KW - fungicides KW - seasonal variations KW - pesticides KW - occupational exposure KW - H SE5.1:BASIC APPROACHES, CONCEPTS, AND THEORY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16066789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Crandall%3BReh%2C+C+M&rft.aulast=Crandall&rft.aufirst=&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=Botanic+garden+horticultural+worker+exposure+to+pesticides.&rft.title=Botanic+garden+horticultural+worker+exposure+to+pesticides.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Comparison of the cancer risk of methylene chloride predicted from animal bioassay data with the epidemiologic evidence. AN - 16050218; 2614113 AB - Methylene chloride has been shown to be a lung and liver carcinogen in the mouse; yet, the current epidemiologic data show no adverse health effects associated with chronic exposure to this compound. Hearne et al. have compared the results of a large mortality study on occupational exposure to methylene chloride to the human risk predictions based on the rodent bioassay to point out the inconsistency between the animal toxicologic and human epidemiologic data. The maximum number of lung and liver cancers predicted due to methylene chloride exposure based on rodent bioassay data was 24 compared to 14 deaths from these cancers actually observed in the Hearne et al. epidemiology study. We assess the minimum risk detectable by the human study in order to calculate the upperbound potency of methylene chloride and compare it to the potency derived from the bioassay data. JF - Risk Analysis AU - Tollefson, L AU - Lorentzen, R J AU - Brown, R N AU - Springer, JA AD - Off. Nutr. and Food Sci., Cent. Food Saf. and Appl. Nutr., FDA, Washington, DC 20204, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 429 EP - 435 VL - 10 IS - 3 SN - 0272-4332, 0272-4332 KW - methylene chloride KW - Risk Abstracts KW - animals KW - carcinogenesis KW - bioassays KW - epidemiology KW - R2 23040:Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16050218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Comparison+of+the+cancer+risk+of+methylene+chloride+predicted+from+animal+bioassay+data+with+the+epidemiologic+evidence.&rft.au=Tollefson%2C+L%3BLorentzen%2C+R+J%3BBrown%2C+R+N%3BSpringer%2C+JA&rft.aulast=Tollefson&rft.aufirst=L&rft.date=1990-01-01&rft.volume=10&rft.issue=3&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - bioassays; epidemiology; animals; carcinogenesis ER - TY - BOOK T1 - An investigation of dust generation mechanisms by free falling powders. AN - 16046934; 2617107 AB - Presently, empirical dustiness tests are used by powder producers to develop "low dusting" powders. Unfortunately, field studies have shown a lack of correlation between dustiness test results and worker dust exposures. Such results may follow from the empirical nature of dustiness tests. The extent to which aerosol generation in the dustiness tester simulates aerosol generation in a powder handling process is not known. Before successful dustiness tests can be devised, a fundamental understanding of dust generation by falling powders is need. As a first step, the processes contributing to aerosol generation by free falling powders need to be identified. This paper describes initial research into the mechanisms of aerosol generation by falling powders. AU - Heitbrink, WA AU - Baron, P A AU - Willeke, K Y1 - 1990 PY - 1990 DA - 1990 SP - 1 EP - 34 KW - dust KW - pollutant dispersion KW - monitoring measurements KW - Health & Safety Science Abstracts; Pollution Abstracts KW - aerosols KW - simulation KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16046934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Heitbrink%2C+WA%3BBaron%2C+P+A%3BWilleke%2C+K&rft.aulast=Heitbrink&rft.aufirst=WA&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=34&rft.isbn=&rft.btitle=An+investigation+of+dust+generation+mechanisms+by+free+falling+powders.&rft.title=An+investigation+of+dust+generation+mechanisms+by+free+falling+powders.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Mycotoxin methodology. AN - 15978084; 2556846 AB - The development of methods with high specificity and low limits of determination, as well as screening methods that are convenient for detection and rough quantitation of mycotoxins, has proceeded at an accelerating rate over the past few years. Of particular interest has been the widespread application of high performance liquid chromatographic and immunoassay techniques in mycotoxin methodology. An overview of the latest developments in mycotoxin methodology is presented with emphasis on the need for attention to sampling and sample preparation, the basic principles supporting the analytical methodology, the need for techniques to confirm analyte identification, and the requirement for high-quality reference materials. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Pohland, A E AU - Thorpe, C W AU - Nesheim, S AD - FDA, Div. Chem. and Phys., HFF-454, 200 C St. SW, Washington, DC 20204, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 110 EP - 119 VL - 10 IS - 3 SN - 0731-8898, 0731-8898 KW - methodology KW - mycotoxins KW - chemical analysis KW - detection KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - immunoassays KW - high-performance liquid chromatography KW - A 01022:Mycotoxins KW - X 24171:Microbial KW - K 03082:Mycotoxins KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15978084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Mycotoxin+methodology.&rft.au=Pohland%2C+A+E%3BThorpe%2C+C+W%3BNesheim%2C+S&rft.aulast=Pohland&rft.aufirst=A&rft.date=1990-01-01&rft.volume=10&rft.issue=3&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - high-performance liquid chromatography; immunoassays ER - TY - JOUR T1 - Mortality among workers exposed to ethylene oxide. AN - 15966247; 2535635 AB - Ethylene oxide is a sterilant gas that causes leukemia and other cancers in animals. Studies in Sweden have shown an excess of leukemia and stomach cancer in humans exposed to ethylene oxide, but other studies have generally failed to confirm these findings. We conducted a study of mortality in 18,254 U.S. workers exposed to ethylene oxide at 14 plants producing sterilized medical supplies and spices. The subjects averaged 4.9 years of exposure to the gas and 16 years of follow-up. The exposure levels in recent years averaged 4.3 ppm (eight-hour time-weighted adjusted exposure) for sterilizer operators and 2.0 ppm for other workers. The levels in earlier years are likely to have been several times higher. Mortality in this cohort was compared with that in the general U.S. population. For the entire cohort, there was no increase in mortality from hematopoietic cancer. There was a slight but significant increase among men, however. Among men and women combined, there was a trend toward an increased risk of death from hematopoietic cancer with increasing lengths of time since the first exposure to ethylene oxide. JF - New England Journal of Medicine AU - Steenland, K AU - Stayner, L AU - Greife, A AU - Halperin, W AU - Hayes, R AU - Hornung, R AU - Nowlin, S AD - R-13, NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 1402 EP - 1407 VL - 324 IS - 20 SN - 0028-4793, 0028-4793 KW - ethylene oxide KW - hemopoietic system KW - carcinoma KW - man KW - hematopoietic system KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - mortality KW - occupational exposure KW - cancer KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15966247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Mortality+among+workers+exposed+to+ethylene+oxide.&rft.au=Steenland%2C+K%3BStayner%2C+L%3BGreife%2C+A%3BHalperin%2C+W%3BHayes%2C+R%3BHornung%2C+R%3BNowlin%2C+S&rft.aulast=Steenland&rft.aufirst=K&rft.date=1990-01-01&rft.volume=324&rft.issue=20&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - mortality; occupational exposure; cancer; hemopoietic system; carcinoma; man ER - TY - JOUR T1 - Modulation of biological processes by mineral fiber adsorption of macromolecules in vitro. AN - 15957937; 2536243 AB - Three classes of macromolecules (i.e., DNA RNA, and protein) were shown to be adsorbed to asbestiform minerals. The cytotoxicity exerted by the fibers on a normal human fibroblast cell line, which may be an indicator of the carcinogenic potential of mineral fibers, correlated positively with the degree of macromolecular adsorption of the fiber, namely: chrysotile > amosite > glass fiber. Asbestiform fibers also induce an alteration in in vitro DNA hydrolysis by bovine pancreatic deoxyribonuclease. This phenomenon suggests that adsorption by asbestiform minerals may modulate biological processes by inducing a conformational change in biological macromolecules as a result of coulombic interaction between the surface charge of the fiber and the hydrophilic groups on the macromolecule. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Chang, MJW AU - Joseph, L B AU - Stephens, R E AU - Hart, R W AD - Dep. Health and Hum. Serv., FDA, Natl. Cent. Toxicol. Res. HFT-1, Jefferson, AR 72079, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 89 EP - 93 VL - 10 IS - 1-2 SN - 0731-8898, 0731-8898 KW - minerals KW - adsorption KW - macromolecules KW - cytotoxicity KW - biological processes KW - asbestos KW - Toxicology Abstracts KW - fibers KW - RNA KW - DNA KW - proteins KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15957937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Modulation+of+biological+processes+by+mineral+fiber+adsorption+of+macromolecules+in+vitro.&rft.au=Chang%2C+MJW%3BJoseph%2C+L+B%3BStephens%2C+R+E%3BHart%2C+R+W&rft.aulast=Chang&rft.aufirst=MJW&rft.date=1990-01-01&rft.volume=10&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - fibers; DNA; RNA; proteins ER - TY - JOUR T1 - Pharmacologic manipulation of the murine pulmonary biochemical response to NO sub(2). AN - 15950916; 2532522 AB - The possible sources of biochemical changes in the lung, including changes in activities of lactate dehydrogenase (LDH), beta-glucuronidase ( beta -GLU), choline kinase (CHK), and protease inhibitor (PI), as well as protein content, were evaluated following exposure to NO sub(2). Hydroxyurea-induced granulocytopenia attenuated the LDH and beta -GLU responses (46% and 61%, respectively) following acute, but not subacute, exposure to NO sub(2). Increases in PI activity and pulmonary protein content following exposure to NO sub(2) were not altered by inhibition of protein synthesis by cycloheximide. The observed increase in PI activity appears to result from an activation process, whereas a major source of increased pulmonary protein content following exposure appears to occur from leakage into the lung. The response of the lung to irritant insult is thus dynamic, and the contribution from various sources to the biochemical makeup of the lung following irritant insult may depend on the phase of the pulmonary response. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Siegel, P D AU - George, W J AD - NIOSH/ALOSH, Immunol. Sect., Room 215, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 231 EP - 236 VL - 10 IS - 4-5 SN - 0731-8898, 0731-8898 KW - nitrogen dioxide KW - biochemistry KW - mice KW - Toxicology Abstracts KW - lung KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15950916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Pharmacologic+manipulation+of+the+murine+pulmonary+biochemical+response+to+NO+sub%282%29.&rft.au=Siegel%2C+P+D%3BGeorge%2C+W+J&rft.aulast=Siegel&rft.aufirst=P&rft.date=1990-01-01&rft.volume=10&rft.issue=4-5&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - lung ER - TY - JOUR T1 - Incidence of urea-hydrolyzing Vibrio parahaemolyticus in Willapa Bay, Washington. AN - 15939399; 2516143 AB - A high incidence (71.5%) of Vibrio parahaemolyticus was found in samples of water, oysters, and sediment from a Washington State estuary which produces a significant amount of commercial product. Strains of V. parahaemolyticus capable of hydrolyzing urea comprised 58.4% of all V. parahaemolyticus isolates tested. Values for fecal coliforms were within certification criteria for commercial harvest and were not correlated with levels of V. parahemolyticus . JF - Applied and Environmental Microbiology AU - Kaysner, CA AU - Abeyta, C Jr AU - Stott, R F AU - Lilja, J L AU - Wekell, M M AD - Seafood Prod. Res. Cent., FDA, Bothell, WA 98041-3012, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 904 EP - 907 VL - 56 IS - 4 SN - 0099-2240, 0099-2240 KW - USA, Washington, Willapa Bay KW - human diseases KW - incidence KW - microbial contamination KW - pathogenic bacteria KW - urea KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts B: Bacteriology KW - Marine KW - INE, USA, Washington, Willapa Bay KW - Vibrio parahaemolyticus KW - hydrolysis KW - public health KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08484:Species interactions: parasites and diseases KW - J 02905:Water KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15939399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Incidence+of+urea-hydrolyzing+Vibrio+parahaemolyticus+in+Willapa+Bay%2C+Washington.&rft.au=Kaysner%2C+CA%3BAbeyta%2C+C+Jr%3BStott%2C+R+F%3BLilja%2C+J+L%3BWekell%2C+M+M&rft.aulast=Kaysner&rft.aufirst=CA&rft.date=1990-01-01&rft.volume=56&rft.issue=4&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - pathogenic bacteria; urea; microbial contamination; human diseases; hydrolysis; public health; Vibrio parahaemolyticus; INE, USA, Washington, Willapa Bay; Marine ER - TY - JOUR T1 - Estimation of the joint risk from multiple-compound exposure based on single-compound experiments. AN - 15915661; 2497640 AB - In the absence of data from multiple-compound exposure experiments, the health risk from exposure to a mixture of chemical carcinogens is generally based on the results of the individual single-compound experiments. A procedure to obtain an upper confidence limit on the total risk is proposed under the assumption that total risk for the mixture is additive. It is shown that the current practice of simply summing the individual upper-confidence-limit risk estimates as the upper-confidence-limit estimate on the total excess risk of the mixture may overestimate the true upper bound. In general, if the individual upper-confidence-limit risk estimates are on the same order of magnitude, the proposed method gives a smaller upper-confidence-limit risk estimate than the estimate based on summing the individual upper-confidence-limit estimates; the difference increases as the number of carcinogenic components increases. JF - Risk Analysis AU - Chen, J J AU - Gaylor, D W AU - Kodell, R L AD - Natl. Cent. Toxicol. Res., U.S. FDA, Jefferson, AR 72079, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 285 EP - 290 VL - 10 IS - 2 SN - 0272-4332, 0272-4332 KW - chemicals KW - risk assessment KW - Risk Abstracts; Health & Safety Science Abstracts KW - bioassays KW - carcinogenesis KW - public health KW - H SM3.8.2:CHEMICALS (CORROSION) KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15915661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Estimation+of+the+joint+risk+from+multiple-compound+exposure+based+on+single-compound+experiments.&rft.au=Chen%2C+J+J%3BGaylor%2C+D+W%3BKodell%2C+R+L&rft.aulast=Chen&rft.aufirst=J&rft.date=1990-01-01&rft.volume=10&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - carcinogenesis; public health; bioassays ER - TY - JOUR T1 - Cloning of the listeriolysin O gene and development of specific gene probes for Listeria monocytogenes . AN - 15903921; 2489830 AB - A clone containing 3.1 kb of Listeria DNA was selected from a gene library of Listeria monocytogenes Scott A strain. The Escherichia coli clone produced hemolysin on sheep blood agar and in sonicated extracts but very little in the culture supernatant. This 3.1-kb DNA fragment and a 650-bp HindIII fragment located within the listeriolysin gene were used as probes in a colony hybridization assay. Both probes were specific for L. monocytogenes and did not hybridize with any other Listeria strains at high stringency. Two synthetic probes, one from the 650-bp HindIII fragment and one from the carboxy-terminal region of the protein, were also specific for L. monocytogenes . JF - Applied and Environmental Microbiology AU - Datta, A R AU - Wentz, BA AU - Russell, J AD - Div. Microbiol., Cent. Food Saf. and Appl. Nutr., FDA, Washington, DC 20204, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 3874 EP - 3877 VL - 56 IS - 12 SN - 0099-2240, 0099-2240 KW - Listeria monocytogenes KW - listeriolysin O KW - Escherichia coli KW - cloning KW - genes KW - hemolysins KW - listeriosis KW - probes KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - G 07320:Bacterial genetics KW - W 30123:Conjugation, transformation and transposition KW - N 14684:Expression of cloned genes KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15903921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Cloning+of+the+listeriolysin+O+gene+and+development+of+specific+gene+probes+for+Listeria+monocytogenes+.&rft.au=Datta%2C+A+R%3BWentz%2C+BA%3BRussell%2C+J&rft.aulast=Datta&rft.aufirst=A&rft.date=1990-01-01&rft.volume=56&rft.issue=12&rft.spage=3874&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; hemolysins; genes; cloning; probes; listeriosis ER - TY - JOUR T1 - Variation in epitopes of the B subunit of Vibrio cholerae non-O1 and Vibrio mimicus cholera toxins. AN - 15865030; 2450334 AB - Monoclonal antibodies reacting with the B subunit of Vibrio cholerae O1 strain 569B cholera toxin (CT-B) were used to identify unique and common epitopes of V. cholerae non-O1 and Vibrio mimicus CT-B. Vibrio cholerae non-O1 strains produced CT-B showing three monoclonal antibody reaction patterns (epitypes), which corresponded with epitypes described previously for V. cholerae O1 classical biotype CT-B (CT1), El Tor biotype CT-B (CT2), and a unique V. cholerae non-O1 CT-B (CT3), which lacked an epitope located in or near the GM sub(1) ganglioside binding site of 569B CT-B. Vibrio mimicus) CT-B was immunologically indistinguishable from 569B CT-B. These and previous results define six epitopes on 569B CT-B, and a fourth epitope in or near the GM sub(1) ganglioside binding site. JF - CAN. J. MICROBIOL./J. CAN. MICROBIOL. AU - Tamplin, M L AU - Jalali, R AU - Ahmed, M K AU - Colwell, R R AD - U.S. FDA, Fish. Res. Branch, Box 158, Dauphin Island, AL 36528, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 409 EP - 413 VL - 36 IS - 6 SN - 0008-4166, 0008-4166 KW - Vibrio cholerae KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - cholera KW - antigenic determinants KW - toxins KW - Vibrio mimicus KW - monoclonal antibodies KW - J 02832:Antigenic properties and virulence KW - F 06008:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15865030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CAN.+J.+MICROBIOL.%2FJ.+CAN.+MICROBIOL.&rft.atitle=Variation+in+epitopes+of+the+B+subunit+of+Vibrio+cholerae+non-O1+and+Vibrio+mimicus+cholera+toxins.&rft.au=Tamplin%2C+M+L%3BJalali%2C+R%3BAhmed%2C+M+K%3BColwell%2C+R+R&rft.aulast=Tamplin&rft.aufirst=M&rft.date=1990-01-01&rft.volume=36&rft.issue=6&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=CAN.+J.+MICROBIOL.%2FJ.+CAN.+MICROBIOL.&rft.issn=00084166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vibrio mimicus; toxins; antigenic determinants; monoclonal antibodies; cholera ER - TY - JOUR T1 - Electrostatic effects in asbestos sampling I: Experimental measurements. AN - 15864785; 2462945 AB - Electrostatic charge can cause errors during sampling of airborne asbestos fibers and other particles. The change in particle trajectories caused by charge effects during sampling can result in nonuniform deposits on the collecting filter surface and net loss of sample. The degree of these electrostatic effects depends on particle charge, sampler charge, sampler conductivity, and sampling flow rate and direction. The purpose of this research was to evaluate the dependence of sampling efficiency and sample uniformity on these variables. Humidity has been postulated as a primary determinant of particle charge during aerosol generation. JF - American Industrial Hygiene Association Journal AU - Baron, P A AU - Deye, G J AD - Div. Phys. Sci. and Eng., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 51 EP - 62 VL - 51 IS - 2 SN - 0002-8894, 0002-8894 KW - asbestos KW - electrostatic effects KW - Pollution Abstracts KW - fibers KW - air sampling KW - occupational health KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15864785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Electrostatic+effects+in+asbestos+sampling+I%3A+Experimental+measurements.&rft.au=Baron%2C+P+A%3BDeye%2C+G+J&rft.aulast=Baron&rft.aufirst=P&rft.date=1990-01-01&rft.volume=51&rft.issue=2&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - air sampling; occupational health; fibers ER - TY - JOUR T1 - Induction of morphological transformation by coal-dust extract in BALB/3T3 A31-1-13 cell line. AN - 15850805; 2441942 AB - The transforming activity of coal dust extracts was studied using BALB/3T3 clone A31-1-13 cells. Coal-dust extracts, both nitrosated and nonnitrosated, induced cell transformation in a dose-response manner. However, the transformation frequency was higher with the nitrosated than with the nonnitrosated extract. All transformed cell lines derived from coal-dust extract-induced foci showed biological characteristics of neoplastic transformation such as loss of contact inhibition and anchorage-independent growth. These results appear to support a hypothesis of coal mine dust causation of gastric cancer in coal miners. JF - Mutation Research AU - Wu, Z-L AU - Chen, J-K AU - Ong, T AU - Matthews, E J AU - Whong, Wen-Zong AD - Microbiol. Sect., DRDS, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 225 EP - 230 VL - 242 IS - 3 SN - 0027-5107, 0027-5107 KW - coal KW - nitrosation KW - coal-dust extract KW - BALB/3T3 cells KW - transformation KW - neoplasia KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - mutation KW - dust KW - H SM5.8.7:DUST KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15850805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Induction+of+morphological+transformation+by+coal-dust+extract+in+BALB%2F3T3+A31-1-13+cell+line.&rft.au=Wu%2C+Z-L%3BChen%2C+J-K%3BOng%2C+T%3BMatthews%2C+E+J%3BWhong%2C+Wen-Zong&rft.aulast=Wu&rft.aufirst=Z-L&rft.date=1990-01-01&rft.volume=242&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; mutation; transformation; neoplasia ER - TY - BOOK T1 - The mutagenic properties of four coal/diesel size fractions. AN - 15841894; 2438148 AB - Diesel-powered equipment is widely used in underground metal/non-metal mines as well as underground coal mines because of its increased flexibility and productivity. However, concerns about the carcinogenicity of the diesel exhaust particulate have increased. NIOSH's Current Intelligence Bulletin 50: "Carcinogenic Effects of Exposure to Diesel Exhaust" published in August of 1988 focused on this concern. This document identified the need to identify the fraction of diesel exhaust containing the causative agent or combination of agents. The project reported collected dust from three coal mines using diesel-powered equipment, one coal mine using electric-powered equipment only, and two metal/non-metal mines using diesel-powered equipment. AU - Stanevich, R S AU - Ong, Tong-Man Y1 - 1990 PY - 1990 DA - 1990 SP - 1 EP - 182 KW - diesel KW - Pollution Abstracts; Health & Safety Science Abstracts KW - mining KW - mutagens KW - carcinogenesis KW - coal KW - fractionation KW - H SM5.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI2.20:COAL INDUSTRIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15841894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stanevich%2C+R+S%3BOng%2C+Tong-Man&rft.aulast=Stanevich&rft.aufirst=R&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=182&rft.isbn=&rft.btitle=The+mutagenic+properties+of+four+coal%2Fdiesel+size+fractions.&rft.title=The+mutagenic+properties+of+four+coal%2Fdiesel+size+fractions.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Ammonia and ethylene oxide permeation through selected protective clothing. AN - 15838552; 2430052 AB - An automated permeation test system was developed to collect permeation data. Three test specimens were evaluated simultaneously versus a challenge gas. The study evaluated chemical protective clothing garment materials for use by emergency response personnel confronted by ammonia or ethylene oxide in the gas phase. A total of 13 encapsulating suit materials and 2 glove materials were tested. Surgical latex material is not recommended for use in handling ammonia or ethylene oxide; other materials offer much greater protection. JF - American Industrial Hygiene Association Journal AU - Berardinelli, S P AU - Moyer, E S AU - Hall, R C AD - DHHS, Public Health Serv., Cent. Dis. Control, NIOSH, Div. Saf. Res., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 595 EP - 600 VL - 51 IS - 11 SN - 0002-8894, 0002-8894 KW - ammonia KW - ethylene oxide KW - Health & Safety Science Abstracts KW - materials testing KW - protective clothing KW - H SI6.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15838552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Ammonia+and+ethylene+oxide+permeation+through+selected+protective+clothing.&rft.au=Berardinelli%2C+S+P%3BMoyer%2C+E+S%3BHall%2C+R+C&rft.aulast=Berardinelli&rft.aufirst=S&rft.date=1990-01-01&rft.volume=51&rft.issue=11&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - protective clothing; materials testing ER - TY - BOOK T1 - Presence of endotoxins in different agricultural environments. AN - 15832294; 2438808 AB - Gram-negative bacterial endotoxins are contaminants of dusts from agricultural products. They represent a potential health hazard for farmers working in many different process. However, the occurrence of endotoxins has not been well characterized in the various farming operations. Therefore, two farming activities with potential for generating airborne endotoxins were studied: chopping of baled corn stalks or straw for bedding in New York State, and oat bin unloading in Alabama. Actual airborne endotoxin levels in dusts obtained during bedding chopper operations far exceeded (90 endotoxin units (EU)/m super(3)) the level at which acute pulmonary function decrements occur in cotton dust-exposed individuals. Endotoxin contamination of laboratory-generated dust from an oat sample likewise exceeded these levels. JF - American Journal of Industrial Medicine. 1990. AU - Olenchock, SA AU - May, J J AU - Pratt, D S AU - Piacitelli, LA AU - Parker, JE Y1 - 1990 PY - 1990 DA - 1990 KW - endotoxins KW - agricultural ecosystems KW - gram-negative bacteria KW - respiratory tract diseases KW - man KW - respiratory diseases KW - Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology KW - agriculture KW - ecosystems KW - bacteria KW - J 02822:Biosynthesis and physicochemical properties KW - H SM10.24:PULMONARY DISEASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15832294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Olenchock%2C+SA%3BMay%2C+J+J%3BPratt%2C+D+S%3BPiacitelli%2C+LA%3BParker%2C+JE&rft.aulast=Olenchock&rft.aufirst=SA&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Presence+of+endotoxins+in+different+agricultural+environments.&rft.title=Presence+of+endotoxins+in+different+agricultural+environments.&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Real-time measurement and control of waste anesthetic gases during veterinary surgeries. AN - 15823222; 2416816 AB - Veterinary clinics are typically small businesses without access to sophisticated occupational safety and health programs that may exist for larger firms or hospitals. Exposures to waste anesthetic gases have been linked to a myriad of adverse health-related conditions. Excessive exposure to anesthetic agents are possible because many of the clinics use portable gas delivery carts that are not designed to capture waste gases. While scavenging systems are available to remove waste anesthetic gases, the cost may be prohibitive for smaller clinics and the effectiveness of these systems has not been fully established in veterinary clinics. JF - American Industrial Hygiene Association Journal AU - Burkhart, JE AU - Stobbe, T J AD - NIOSH, Div. Respir. Dis. Stud., 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 640 EP - 645 VL - 51 IS - 12 SN - 0002-8894, 0002-8894 KW - gases KW - surgery KW - anaesthetics KW - Health & Safety Science Abstracts KW - waste management KW - occupational health KW - H SM1.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15823222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Real-time+measurement+and+control+of+waste+anesthetic+gases+during+veterinary+surgeries.&rft.au=Burkhart%2C+JE%3BStobbe%2C+T+J&rft.aulast=Burkhart&rft.aufirst=JE&rft.date=1990-01-01&rft.volume=51&rft.issue=12&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - waste management; occupational health ER - TY - BOOK T1 - Workplace protection factor (WPF) study of particulate air purifying respirators at lead-acid battery manufacturing facilities. AN - 15815751; 2414051 AB - Workplace Protection Factors (WPF) were measured for more than 150 workers at three lead-acid battery manufacturing facilities. Worker measurements included personal ambient concentrations on the lapel and concentrations inside the facepiece. Quantitative fit tests, pulmonary deposition and pressure versus time measurements were collected on a sample of workers. Area samples were collected with impactors to evaluate particle size distribution (PSD) of the lead and other particulates. Deposition on sampling cassette walls was measured. Particle size distribution was used to calculate in-facepiece PSD and estimate lung and probe sample deposition. AU - Pallay, B AU - Gamble, J AU - Jeram, L AU - Allender, J AU - Hewett, P AU - Petersen, M AU - Stevens, J AU - Bauman, S AU - Greiss, T Y1 - 1990 PY - 1990 DA - 1990 SP - 1 EP - 90 KW - occupational safety KW - Health & Safety Science Abstracts KW - batteries KW - purification KW - respirators KW - manufacturing industry KW - particulates KW - H SI8.13:INSTRUMENTATION, DEVICES AND CONTROLS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15815751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pallay%2C+B%3BGamble%2C+J%3BJeram%2C+L%3BAllender%2C+J%3BHewett%2C+P%3BPetersen%2C+M%3BStevens%2C+J%3BBauman%2C+S%3BGreiss%2C+T&rft.aulast=Pallay&rft.aufirst=B&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=90&rft.isbn=&rft.btitle=Workplace+protection+factor+%28WPF%29+study+of+particulate+air+purifying+respirators+at+lead-acid+battery+manufacturing+facilities.&rft.title=Workplace+protection+factor+%28WPF%29+study+of+particulate+air+purifying+respirators+at+lead-acid+battery+manufacturing+facilities.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - BOOK T1 - A job exposure matrix for identification of exposures in occupational settings. AN - 15812442; 2414110 AB - A job exposure matrix has been developed based on data collected during the 1972-1974 National Occupational Hazard Survey (NOHS). Potential exposures to 8,342 chemical, physical, or biological agents observed across 442 occupations and 629 industries were recorded in the NOHS if certain minimum guidelines for exposure were met. The survey sample was representative of all U.S. non-agricultural businesses covered under the OSHAct and employing eight or more employees. Potential exposure data collected during the NOHS is cross-classified by industry and occupation in the job exposure matrix. Data on the number of employees observed to be potentially exposed to the agent, the number of employees exposed full time, presence of engineering controls over exposure, and presence of the agent in a trade-named product is included in the job exposure matrix. AU - Sieber, WK Jr Y1 - 1990 PY - 1990 DA - 1990 KW - surveys KW - biology KW - Health & Safety Science Abstracts KW - data collection KW - physicochemical properties KW - occupational exposure KW - H SI0.2:DATA ANALYSIS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15812442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sieber%2C+WK+Jr&rft.aulast=Sieber&rft.aufirst=WK&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+job+exposure+matrix+for+identification+of+exposures+in+occupational+settings.&rft.title=A+job+exposure+matrix+for+identification+of+exposures+in+occupational+settings.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Exact versus asymptotic tests of trend of tumor prevalence in tumorigenicity experiments: A comparison of P-values for small frequency of tumors. AN - 15812384; 2400573 AB - In the statistical evaluation of a tumorigenicity experiment, a commonly used test is the prevalence test of Hoel and Walburg. This test is based on an extension of the Mantel-Haenszel (MH) statistic for combining s( greater than or equal to 2) 2 x k tables where k greater than or equal to 2. This paper presents the results of a simulation study whereby the P-values obtained by the usual normal approximation and a continuity corrected normal approximation to MH are compared with the exact P-values (ie, P-values obtained from the exact permutational distribution of MH) using four different score sets. The normal approximation (without continuity correction) was severely underestimating the exact P-values. The continuity correction approximated the exact P-values with a high degree of accuracy when the (exact) distribution was fairly symmetric and n sub(T) greater than or equal to 3. As n sub(T) increased, the exact P-values tended to decrease with an increase in the dispersion of the upper (medium and high) scores. JF - Drug Information Journal AU - Ali, M W Y1 - 1990 PY - 1990 DA - 1990 SP - 727 EP - 737 VL - 24 IS - 4 KW - tumorigenicity testing KW - statistical analysis KW - P-values KW - Mantel-Haenszel test KW - prevalence test KW - tumours KW - Toxicology Abstracts KW - toxicity testing KW - dose-response effects KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15812384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Exact+versus+asymptotic+tests+of+trend+of+tumor+prevalence+in+tumorigenicity+experiments%3A+A+comparison+of+P-values+for+small+frequency+of+tumors.&rft.au=Ali%2C+M+W&rft.aulast=Ali&rft.aufirst=M&rft.date=1990-01-01&rft.volume=24&rft.issue=4&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - BOOK T1 - Respirable dust criteria for submicrometer aerosols. AN - 15812146; 2417320 AB - The Air Sampling Procedures Committee of the ACGIH has adopted criteria for size selective sampling of aerosols. A review of the data on the size distributions of aerosols reveals that there are a number of contaminants which are present in large part as submicrometer aerosol. The contaminants include acid mist, metal fumes, and diesel exhaust particulate. Attempts at contaminant control can change the size distribution of the aerosol. Depending on the control the resultant product may be either smaller or larger though still largely submicrometer in nature. Because the lung deposition curve reaches a minimum at approximately 0.5 mu m, a change in the aerosol size distribution may increase dose even though the apparent respirable dust level is decreased. AU - McCawley, MA AU - Hewett, P Y1 - 1990 PY - 1990 DA - 1990 SP - 1 EP - 185 KW - air sampling KW - Pollution Abstracts; Health & Safety Science Abstracts KW - particle size KW - dust KW - aerosols KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15812146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McCawley%2C+MA%3BHewett%2C+P&rft.aulast=McCawley&rft.aufirst=MA&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=185&rft.isbn=&rft.btitle=Respirable+dust+criteria+for+submicrometer+aerosols.&rft.title=Respirable+dust+criteria+for+submicrometer+aerosols.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - BOOK T1 - Industrial hygiene characterization of carbon monoxide exposures of bridge and tunnel workers in NYC. AN - 15810534; 2413412 AB - NIOSH research conducted an exposure characterization study in conjunction with a historical prospective mortality study of bridge and tunnel officers (BTOs) exposed to carbon monoxide (CO) from motor vehicle exhaust. An in-depth industrial hygiene survey was conducted at one tunnel and one bridge to characterize 8-hour time-weighted average (TWA) CO inhalation exposures to bridge and tunnel workers while working inside plaza toll booths, tunnel observation booths, in toll lanes and tunnel entrances, and on the tunnel catwalks. AU - Ringenburg, V L AU - McCammon, C S AU - Stern, F B AU - Lee, ST Y1 - 1990 PY - 1990 DA - 1990 SP - 2 EP - 196 KW - occupational health KW - Health & Safety Science Abstracts KW - carbon monoxide KW - automotive exhaust emissions KW - mortality KW - bridges KW - H SI1.8.2:CHEMICALS (CORROSION) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15810534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Ringenburg%2C+V+L%3BMcCammon%2C+C+S%3BStern%2C+F+B%3BLee%2C+ST&rft.aulast=Ringenburg&rft.aufirst=V&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=Industrial+hygiene+characterization+of+carbon+monoxide+exposures+of+bridge+and+tunnel+workers+in+NYC.&rft.title=Industrial+hygiene+characterization+of+carbon+monoxide+exposures+of+bridge+and+tunnel+workers+in+NYC.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Method for improving accuracy of virus titration: Standardization of plaque assay for Junin virus. AN - 15810502; 2419913 AB - Titrating infective virus is one of the most important and common techniques in virology. However, after many years of widespread use, the parameters governing the accuracy of titration values are still not well understood. It was found that under conditions currently used for virus titration, only a small percentage of virus in the inoculum is adsorbed onto the cells and thereby detected in the titration assay. The objective of our work was to establish the conditions for a plaque assay which could estimate more accurately the titer of Junin virus. Two different stain methods were compared and several parameters governing plaque formation were studied. The volume of the inoculum appeared as the most important factor affecting observed titer. JF - Journal of Virological Methods AU - Bushar, G AU - Sagripanti, J-L AD - Mol. Biol. Branch, Div. Life Sci., Cent. Devices and Radiol. Health, FDA, 12709 Twinbrook Parkw., Rockville, MD 20850, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 99 EP - 108 VL - 30 IS - 1 SN - 0166-0934, 0166-0934 KW - Junin virus KW - standardization KW - titration KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - plaque assay KW - A 01114:Viruses KW - V 22022:Virus assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15810502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Method+for+improving+accuracy+of+virus+titration%3A+Standardization+of+plaque+assay+for+Junin+virus.&rft.au=Bushar%2C+G%3BSagripanti%2C+J-L&rft.aulast=Bushar&rft.aufirst=G&rft.date=1990-01-01&rft.volume=30&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - plaque assay ER - TY - BOOK T1 - Application of a ventilation model to real-time exposure data to estimate contaminant generation rate and/or effective ventilation rate. AN - 15805529; 2413737 AB - Real-time concentration was measured using an instrument with an infrared detector calibrated to nitrous oxide with the output recorded on a data logger. In this study, the ventilation rate and the nitrous oxide generation rate were known, and the efficiency of the rate of ventilation of the operatory was determined. The model compared well with the real-time data and showed the buildup and decay of nitrous oxide in the room as the generation rate of the nitrous oxide was changed. The material balance also was applied to a furniture stripper exposed to methylene chloride and methanol in a small furniture refinishing shop. AU - Jensen, P A AU - Fischbach, T J AU - O'Brien, D M AU - Todd, W F AU - McGlothlin, J D Y1 - 1990 PY - 1990 DA - 1990 SP - 2 EP - 199 KW - ventilation KW - Health & Safety Science Abstracts KW - occupational safety KW - nitrous oxide KW - lumber industry KW - occupational health KW - H SI1.9.4:VENTILATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15805529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jensen%2C+P+A%3BFischbach%2C+T+J%3BO%27Brien%2C+D+M%3BTodd%2C+W+F%3BMcGlothlin%2C+J+D&rft.aulast=Jensen&rft.aufirst=P&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=198&rft.isbn=&rft.btitle=Application+of+a+ventilation+model+to+real-time+exposure+data+to+estimate+contaminant+generation+rate+and%2For+effective+ventilation+rate.&rft.title=Application+of+a+ventilation+model+to+real-time+exposure+data+to+estimate+contaminant+generation+rate+and%2For+effective+ventilation+rate.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - A study of the utilization of the FDA's adverse drug reaction database. AN - 15805343; 2412334 AB - An overview of the uses of the Food and Drug Administration (FDA) Adverse Drug Reaction Reporting system. The procedures for signal generation, monitored adverse reactions, safety conferences, and recommendations are presented. Use of the on-line retrieval system, periodic reports, and Freedom-of-Information requests is discussed. JF - Drug Information Journal AU - Gelberg, A AU - Armstrong, G D AD - Off. Epidemiol. and Biostat., Cent. Drug Eval. and Res., FDA, 5600 Fishers Lane, Rockville, MD 20857, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 785 EP - 793 VL - 24 IS - 4 SN - 0092-8615, 0092-8615 KW - pharmaceuticals KW - FDA KW - information retrieval KW - online systems KW - data banks KW - data bases KW - drugs KW - information systems KW - safety KW - side effects KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - X 24230:Legislation & recommended standards KW - H SI6.2:DATA ANALYSIS KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15805343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=A+study+of+the+utilization+of+the+FDA%27s+adverse+drug+reaction+database.&rft.au=Gelberg%2C+A%3BArmstrong%2C+G+D&rft.aulast=Gelberg&rft.aufirst=A&rft.date=1990-01-01&rft.volume=24&rft.issue=4&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - data bases; safety; side effects; drugs; information systems; data banks ER - TY - BOOK T1 - Occupational exposures to elemental and organic carbon content of diesel exhaust emissions in the trucking industry. AN - 15804351; 2417329 AB - As a part of a case-control mortality study of trucking industry workers, exposures to diesel aerosol were measured among the four major presumably exposed job groups (road drivers, local drivers, dock workers, and mechanics) identifiable from Teamsters Union records. During each of a series of industrial hygiene surveys, conducted during both warm and cold weather at eight U.S. terminals and truck repair shops, personal and area sampling were conducted to evaluate exposures to submicrometer elemental carbon (used as the principal surrogate marker of exposure), submicrometer organic carbon, and several other particulate and gaseous components of diesel exhaust. AU - Zaebst, D D AU - Clapp, DE AU - Blade, L M AU - Morris, JA AU - Hornung, R W Y1 - 1990 PY - 1990 DA - 1990 SP - 2 EP - 186 KW - occupational health KW - diesel KW - Pollution Abstracts; Health & Safety Science Abstracts KW - exhaust emissions KW - trucks KW - mortality KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - H ST2.26:EMISSIONS AND EMISSION CONTROL KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15804351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Zaebst%2C+D+D%3BClapp%2C+DE%3BBlade%2C+L+M%3BMorris%2C+JA%3BHornung%2C+R+W&rft.aulast=Zaebst&rft.aufirst=D&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=185&rft.isbn=&rft.btitle=Occupational+exposures+to+elemental+and+organic+carbon+content+of+diesel+exhaust+emissions+in+the+trucking+industry.&rft.title=Occupational+exposures+to+elemental+and+organic+carbon+content+of+diesel+exhaust+emissions+in+the+trucking+industry.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - System response time and method of pay: Cardiovascular stress effects in computer-based tasks. AN - 15801400; 2406391 AB - Psychophysiological effects of computer system response time (slow vs. rapid) and method of pay (incentive vs. nonincentive) were assessed in a computer-based data entry task among forty-five professional typists. Cardiovascular responses (i.e., heart rate and blood pressure) were monitored on a regular basis over four consecutive workdays. Heart rate and blood pressure did not vary significantly with slow or rapid response times. Incentive pay, however, significantly increased blood pressure and decreased heart rate variability across the workdays compared to nonincentive pay. Irrespective of response time or method of pay, performance of the data entry task for sustained periods of time was associated with reduced heart rate and increased heart rate variability. JF - Ergonomics AU - Schleifer, L M AU - Okogbaa, O G AD - Div. Biomed. and Behav. Sci., NIOSH, 4676 Columbia Parkway, C-24, Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 1495 EP - 1509 VL - 33 IS - 12 SN - 0014-0139, 0014-0139 KW - cardiovascular system KW - data entry KW - blood pressure KW - computer applications KW - ergonomics KW - occupational health KW - physiology KW - psychology KW - stress KW - Health & Safety Science Abstracts KW - H SM9.7:HUMAN FACTORS KW - H SI0.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15801400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=System+response+time+and+method+of+pay%3A+Cardiovascular+stress+effects+in+computer-based+tasks.&rft.au=Schleifer%2C+L+M%3BOkogbaa%2C+O+G&rft.aulast=Schleifer&rft.aufirst=L&rft.date=1990-01-01&rft.volume=33&rft.issue=12&rft.spage=1495&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - stress; computer applications; physiology; psychology; ergonomics; blood pressure; occupational health ER - TY - JOUR T1 - Metabolism of doxylamine succinate in Fischer 344 rats. Part III: Conjugated urinary and fecal metabolites. AN - 15798634; 2413437 AB - Elimination and metabolic profiles of the glucuronide products of doxylamine and its N-demethylated metabolites were determined after the oral administration of ( super(14)C)-doxylamine succinate (13.3 and 133 mg/kg doses) to male and female Fischer 344 rats. The cumulative urinary and fecal eliminations of these conjugated doxylamine metabolites at the 13.3 mg/kg dose were 44.4% and 47.3% of the total recovered dose for male and female rats, respectively. The cumulative urinary and fecal eliminations of conjugated doxylamine metabolites at the 133 mg/kg dose were 55.2% and 47.9% of the total recovered dose for male and female rats, respectively. The conjugated doxylamine metabolites that were isolated, quantitated, and identified are doxylamine O-glucuronide, N-desmethyldoxylamine O-glucuronide, and N,N-didesmethyldoxylamine O-glucuronide. JF - Journal of Analytical Toxicology AU - Holder, CL AU - Siitonen, PH AU - Slikker, W Jr AU - Branscomb, C J AU - Korfmacher, WA AU - Thompson, HC Jr AU - Cerniglia, CE AU - Gosnell, AB AU - Lay, JO Jr AD - FDA, Natl. Cent. Toxicol. Res., Jefferson, AK 72079, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 247 EP - 251 VL - 14 IS - 4 SN - 0146-4760, 0146-4760 KW - doxylamine succinate KW - metabolism KW - metabolites KW - rats KW - Toxicology Abstracts KW - urine KW - feces KW - X 24114:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15798634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Metabolism+of+doxylamine+succinate+in+Fischer+344+rats.+Part+III%3A+Conjugated+urinary+and+fecal+metabolites.&rft.au=Holder%2C+CL%3BSiitonen%2C+PH%3BSlikker%2C+W+Jr%3BBranscomb%2C+C+J%3BKorfmacher%2C+WA%3BThompson%2C+HC+Jr%3BCerniglia%2C+CE%3BGosnell%2C+AB%3BLay%2C+JO+Jr&rft.aulast=Holder&rft.aufirst=CL&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - urine; feces ER - TY - BOOK T1 - Results of the National Occupational Health Survey of Mining. AN - 15798096; 2413571 AB - The National Occupational Health Survey of Mining (NOHSM) was conducted by the National Institute for Occupational Safety and Health (NIOSH) in order to partially fulfill the requirements of the 1969 Coal Mine Health and Safety Act as modified by the Federal Mine Safety and Health Amendments Act of 1977. A total of 491 mine sites, representing 68 commodities, were surveyed. The data gathered are now being analyzed and reported. Initial reporting and database creation are to be completed in Fiscal Year 1991. AU - Bajpayee, S S AU - Roman, J M AU - Groce, D W Y1 - 1990 PY - 1990 DA - 1990 SP - 2 EP - 217 KW - surveys KW - Health & Safety Science Abstracts KW - mining KW - coal KW - physicochemical properties KW - occupational health KW - H SI2.20:COAL INDUSTRIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15798096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bajpayee%2C+S+S%3BRoman%2C+J+M%3BGroce%2C+D+W&rft.aulast=Bajpayee&rft.aufirst=S&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=216&rft.isbn=&rft.btitle=Results+of+the+National+Occupational+Health+Survey+of+Mining.&rft.title=Results+of+the+National+Occupational+Health+Survey+of+Mining.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Bioavailability, metabolism, and renal excretion of benzoic acid in the channel catfish (Ictalurus punctatus ). AN - 15797984; 2412084 AB - The pharmacokinetics and metabolism of the model compound benzoic acid were examined after intravascular (iv) and po administration at 10 mg/kg in the channel catfish (Ictalurus punctatus ). A two-compartment pharmacokinetic model best described the plasma disposition of parent benzoic acid after iv dosing. The following pharmacokinetic values were estimated: elimination half-life, 5.9 hr; total body clearance, 61 ml/hr/kg; and volume of distribution (steady-state), 369 ml/kg. Plasma protein binding of ( super(14)C)benzoic acid was 18%. Benzoic acid was rapidly and extensively absorbed after po administration; absorption half-life was 0.8 hr and bioavailability was 95%. Renal excretion was the primary route of elimination of benzoic acid and metabolites. More than 80% of the iv-administered super(14)C was recovered in the urine in 24 hr. Unchanged benzoic acid comprised more than 90% of the urinary radiolabel. JF - Drug Metabolism and Disposition AU - Plakas, S M AU - James, MO AD - Fish. Res. Branch, U.S. FDA, P.O. Box 158, Dauphin Island, AL 36528, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 552 EP - 556 VL - 18 IS - 5 SN - 0090-9556, 0090-9556 KW - benzoic acid KW - organic acids KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Aquaculture Abstracts KW - self purification KW - detoxification KW - Ictalurus punctatus KW - bioaccumulation KW - Q5 08504:Effects on organisms KW - Q3 08582:Fish culture KW - Q1 08582:Fish culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15797984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=Bioavailability%2C+metabolism%2C+and+renal+excretion+of+benzoic+acid+in+the+channel+catfish+%28Ictalurus+punctatus+%29.&rft.au=Plakas%2C+S+M%3BJames%2C+MO&rft.aulast=Plakas&rft.aufirst=S&rft.date=1990-01-01&rft.volume=18&rft.issue=5&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - self purification; detoxification; bioaccumulation; Ictalurus punctatus ER - TY - JOUR T1 - Clean-up techniques for pesticides in fatty foods. AN - 15787403; 2387583 AB - The separation of pesticides and other chemical contaminants from high-fat food samples prior to subsequent steps in the analytical process (usually gas chromatography) is a problem to which much effort in method development has been applied. Early methods involved liquid-liquid partitioning, adsorption chromatography and chemical destruction of lipids with strong base and acid. These techniques had limited applicability, especially with the advent of more polar and labile pesticides. Later developments involving sweep codistillation, gel-permeation chromatography and reversed-phase liquid chromatography on alkyl-bonded microparticulate silica are applicable to a wider range of analytes and are generally faster and more efficient and consume less reagents. Supercritical fluid extraction should prove useful in this regard. A brief overview of methods developed for isolating trace levels of environmental contaminants from lipids is presented. JF - Analytica Chimica Acta AU - Walters, S M AD - Pestic. and Ind. Chem. Res. Cent., FDA, 1560 E. Jefferson Ave., Detroit, MI 48207, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 77 EP - 82 VL - 236 IS - 1 SN - 0003-2670, 0003-2670 KW - cleaning process KW - foods KW - Health & Safety Science Abstracts; Pollution Abstracts KW - liquid chromatography KW - lipids KW - pesticides KW - H SE4.27:FOOD PROCESSING INDUSTRIES KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15787403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Clean-up+techniques+for+pesticides+in+fatty+foods.&rft.au=Walters%2C+S+M&rft.aulast=Walters&rft.aufirst=S&rft.date=1990-01-01&rft.volume=236&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - pesticides; liquid chromatography; lipids ER - TY - BOOK T1 - National surveillance of occupational fatalities in agriculture. AN - 15787064; 2387930 AB - Agriculture is one of the most hazardous industries in the United States. Although estimates vary, all reporting agencies show agriculture having an occupational fatality rate three to five times higher than that of the general private sector. The National Institute for Occupational Safety and Health (NIOSH), Division of Safety Research's National Traumatic Occupational Fatalities (NTOF) data base monitors occupational fatal injuries in all industries in the United States through death certificates. Uniform case-selection criteria are applied nationwide, NTOF shows that for the years 1980 through 1985, agriculture had a work-related fatality rate of 20.7 deaths per 100,000 workers compared with 7.9 deaths per 100,000 workers for the private sector U.S. work force. Age-specific rates indicate that the risk of a fatal occupational injury increases with age for agricultural workers. Workers over 64 years old have an average annual rate of 55.7 deaths per 100,000 workers. Other uses of the surveillance systems, as well as its limitations, are discussed. JF - American Journal of Industrial Medicine. 1990. AU - Myers, J R Y1 - 1990 PY - 1990 DA - 1990 KW - agriculture KW - Health & Safety Science Abstracts KW - accidents KW - mortality KW - surveys KW - occupational health KW - H SE2.4:ACCIDENT INVESTIGATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15787064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Myers%2C+J+R&rft.aulast=Myers&rft.aufirst=J&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=National+surveillance+of+occupational+fatalities+in+agriculture.&rft.title=National+surveillance+of+occupational+fatalities+in+agriculture.&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Statistical issues in the pharmaceutical industry: Experimental design considerations in drug development. Introduction: Statistical issues in animal safety studies. AN - 15776272; 2378253 AB - The pharmaceutical industry places substantial emphasis on safety evaluation of potentially marketable drugs. Animal studies form the initial basis of this safety evaluation. These studies are conducted primarily to characterize the risks associated with drugs, to determine safe doses, and to minimize the risk of administering experimental drugs to humans. Proper designs for experiments and appropriate methods of data analysis are crucial for valid and efficient evaluation of safety. Both of these aspects are addressed in the papers presented in this section. JF - Drug Information Journal AU - Sanathanan, L P Y1 - 1990 PY - 1990 DA - 1990 SP - 379 VL - 24 IS - 2 KW - drugs KW - laboratory animals KW - pharmaceuticals KW - laboratory testing KW - pharmaceutical industry KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - toxicity testing KW - animals KW - statistics KW - safety KW - H SI6.20:PHARMACEUTICAL INDUSTRIES KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15776272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Information+Journal&rft.atitle=Statistical+issues+in+the+pharmaceutical+industry%3A+Experimental+design+considerations+in+drug+development.+Introduction%3A+Statistical+issues+in+animal+safety+studies.&rft.au=Sanathanan%2C+L+P&rft.aulast=Sanathanan&rft.aufirst=L&rft.date=1990-01-01&rft.volume=24&rft.issue=2&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Drug+Information+Journal&rft.issn=00928615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Occupational confined space-related fatalities: Surveillance and prevention. AN - 15770107; 2379050 AB - The National Institute for Occupational Safety and Health (NIOSH) investigates selected workplace fatalities through the Fatal Accident Circumstances and Epidemiology (FACE) project. This surveillance project is designed to collect descriptive data on selected fatalities using an epidemiologic approach, to identify potential risk factors for work-related death, to develop recommended intervention strategies, to disseminate findings that increase employer and employee hazard awareness and to reduce the risk of fatal injury in the workplace. From December 1983 through December 1989, 55 confined-space events, resulting in 88 deaths, were investigated through the FACE project. In these events only three of the workers who died had received any training in confined space safety. Additionally, only 27% of the employers had any type of written confined space entry procedures. JF - Journal of Safety Research AU - Manwaring, J C AU - Conroy, C AD - Div. Saf. Res., NIOSH, CDC, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 157 EP - 164 VL - 21 IS - 4 SN - 0022-4375, 0022-4375 KW - occupational safety KW - confined spaces KW - NIOSH KW - Health & Safety Science Abstracts KW - accidents KW - epidemiology KW - H SI0.4:ACCIDENT INVESTIGATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15770107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Occupational+confined+space-related+fatalities%3A+Surveillance+and+prevention.&rft.au=Manwaring%2C+J+C%3BConroy%2C+C&rft.aulast=Manwaring&rft.aufirst=J&rft.date=1990-01-01&rft.volume=21&rft.issue=4&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - accidents; epidemiology ER - TY - JOUR T1 - Clay occlusion of respirable quartz particles detected by low voltage scanning electron microscopy--X-ray analysis. AN - 15750859; 2361579 AB - Respirable-sized dust particles from a clay mine and mill were examined for aluminum and silicon content by scanning electron microscopy-energy dispersive X-ray analysis at incident electron energies of 5-20 keV. Most of the high silica content particles, those which has a silicon to silicon plus aluminum signal fraction, measured at 20 keV, of 0.9 or greater, showed a decrease in the silicon fraction of signal with decreasing incident electron energy, down to values of between 0.6 and 0.8 at 5 keV: this decrease was a function of particle size and composition. Simple models for silicon fraction of signal vs incident electron voltage suggest this behaviour is due to a heterogeneous particle structure in which an aluminosilicate coating occludes the surface of a silica particle core. The coating survives incubation in a major component of pulmonary surfactant. JF - Annals of Occupational Hygiene AU - Wallace, W E AU - Harrison, J AU - Keane, MJ AU - Bolsaitis, P AU - Eppelsheimer, D AU - Poston, J AU - Page, S J AD - Div. Respir. Dis. Stud., U.S. NIOSH, Morgantown, WV 26505, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 195 EP - 204 VL - 34 IS - 2 SN - 0003-4878, 0003-4878 KW - occupational health KW - aluminium KW - Health & Safety Science Abstracts KW - respiratory system KW - surfactants KW - dust KW - H SI0.8.7:DUST UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15750859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Clay+occlusion+of+respirable+quartz+particles+detected+by+low+voltage+scanning+electron+microscopy--X-ray+analysis.&rft.au=Wallace%2C+W+E%3BHarrison%2C+J%3BKeane%2C+MJ%3BBolsaitis%2C+P%3BEppelsheimer%2C+D%3BPoston%2C+J%3BPage%2C+S+J&rft.aulast=Wallace&rft.aufirst=W&rft.date=1990-01-01&rft.volume=34&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - dust; respiratory system; surfactants ER - TY - JOUR T1 - Effects of in vitro ozone exposure on peroxidative damage, membrane leakage, and taurine content of rat alveolar macrophages. AN - 15748304; 2376760 AB - Rat alveolar macrophages (AM) were isolated by pulmonary lavage, allowed to adhere to a tissue culture flask, and then exposed to 0.45 plus or minus 0.05 ppm ozone. After exposures ranging from 0 to 60 min, the medium was decanted and cells were harvested. Cells were assayed for oxidant damage and media analyzed for leakage of intracellular components. Increasing length of exposure to ozone resulted in a decreased number of adherent AM and decreased cell viability. Activity of the Na super(+)/K super(+) ATPase decreased with time while intracellular taurine concentration exhibited an initial rise, peaked at 30 min, and then returned to the untreated level. JF - Toxicology and Applied Pharmacology AU - Banks, MA AU - Porter, D W AU - Martin, W G AU - Castranova, V AD - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 55 EP - 65 VL - 105 IS - 1 SN - 0041-008X, 0041-008X KW - lung KW - effects on KW - concentration KW - rats KW - macrophages KW - lipid peroxidation KW - taurine KW - plasma membranes KW - lipids KW - membranes KW - ozone KW - pharmacology KW - Pollution Abstracts; Health & Safety Science Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - H SI6.20:PHARMACEUTICAL INDUSTRIES KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15748304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effects+of+in+vitro+ozone+exposure+on+peroxidative+damage%2C+membrane+leakage%2C+and+taurine+content+of+rat+alveolar+macrophages.&rft.au=Banks%2C+MA%3BPorter%2C+D+W%3BMartin%2C+W+G%3BCastranova%2C+V&rft.aulast=Banks&rft.aufirst=MA&rft.date=1990-01-01&rft.volume=105&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ozone; lipids; membranes; pharmacology ER - TY - JOUR T1 - Fatal abuse of nitrous oxide in the workplace. AN - 15737540; 2352513 AB - Abuse of nitrous oxide (N sub(2)O) while on the job caused at least 11 deaths in 1984 to 1987, as found in investigations by the Occupational Safety and Health Administration and in reports to the Consumer Product Safety Commission. Although nitrous oxide has had a reputation as a "clean and safe" analgesic and anesthetic, the possibility of asphyxiation by inhalation is not widely recognized, and there are no requirements for warning labels on nonmedical sources of N sub(2)O. The 11 deaths involved recreational inhalation of N sub(2)O by young male employees from tanks or cylinders normally used for legitimate business purposes. In six cases, the victims worked in food serving establishments and inhaled N sub(2)O that was used to power whipped cream dispensers. JF - J. OCCUP. MED. AU - Suruda, A J AU - McGlothlin, J D AD - Industrywide Stud. Branch, NIOSH, Robert A. Taft Lab., 4676 Columbia Pkwy., Cincinnati, OH 45226-1998, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 682 EP - 684 VL - 32 IS - 8 SN - 0096-1736, 0096-1736 KW - nitrous oxide KW - Health & Safety Science Abstracts; Pollution Abstracts KW - inhalation KW - occupational health KW - mortality KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15737540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Fatal+abuse+of+nitrous+oxide+in+the+workplace.&rft.au=Suruda%2C+A+J%3BMcGlothlin%2C+J+D&rft.aulast=Suruda&rft.aufirst=A&rft.date=1990-01-01&rft.volume=32&rft.issue=8&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; inhalation; mortality ER - TY - JOUR T1 - The application of dustiness tests to the prediction of worker dust exposure. AN - 15733739; 2352031 AB - Laboratory bench tests, known as dustiness tests, have been used to evaluate and compare the potential of various powders to cause occupational dust exposure. Dustiness tests are used to develop products with reduced dust emissions. The correlation between dustiness test results and dust exposures was evaluated at two bag dumping and bag filling operations. At one bag dumping and one bag filling operation, there was evidence of a relationship between dustiness test results and dust exposures. In one case, regression analysis showed that dust exposures could be predicted to within nearly one order of magnitude. The variability in this prediction was caused by the inherent variability in the occupational dust exposures. In the other case, there was evidence of a correlation after the data had been adjusted for the effect of varying drop height. JF - American Industrial Hygiene Association Journal AU - Heitbrink, WA AU - Todd, W F AU - Cooper, T C AU - O'Brien, D M AD - NIOSH, Div. Phys. Sci. and Eng., Eng. Control Technol. Branch, 4676 Columbia Parkw., Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 217 EP - 223 VL - 51 IS - 4 SN - 0002-8894, 0002-8894 KW - dust KW - Pollution Abstracts KW - air quality KW - laboratory testing KW - occupational health KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15733739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=The+application+of+dustiness+tests+to+the+prediction+of+worker+dust+exposure.&rft.au=Heitbrink%2C+WA%3BTodd%2C+W+F%3BCooper%2C+T+C%3BO%27Brien%2C+D+M&rft.aulast=Heitbrink&rft.aufirst=WA&rft.date=1990-01-01&rft.volume=51&rft.issue=4&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; laboratory testing; air quality ER - TY - JOUR T1 - Surveillance of occupational skin diseases: A method utilizing workers' compensation claims. AN - 15731180; 2358037 AB - In order to determine the feasibility of using workers' compensation claims (WCC) for surveillance of occupational skin diseases, we reviewed all WCC received in the state of Ohio from 1980 through 1984. A total of 4,214 WCC for occupational skin diseases were filed by 2,610 Ohio companies, of which 1,656 (63%) companies were classified in Standard Industrial Classification (SIC) categories with average annual WCC rates above the overall state average for skin diseases. During the five year study period, 102 companies filed six or more WCC, of which 85 (83.3%) companies were classified in SICs with above-average WCC rates. WCC from 65 (63.7%) of these 102 companies implicated either the same occupation or causal agent in 50% or more of WCC received from each respective company. JF - American Journal of Industrial Medicine AU - Mathias, C G AU - Sinks, TH AU - Seligman, P J AU - Halperin, W E AD - Surveill. Branch, R-21, Div. Surveill., Hazard Eval. and Field Stud., NIOSH, Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 363 EP - 370 VL - 17 IS - 3 SN - 0271-3586, 0271-3586 KW - skin diseases KW - compensation KW - claims KW - Health & Safety Science Abstracts KW - feasibility studies KW - occupational health KW - statistics KW - H SM10.38:SKIN DISEASES KW - H SI0.2:DATA ANALYSIS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15731180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Surveillance+of+occupational+skin+diseases%3A+A+method+utilizing+workers%27+compensation+claims.&rft.au=Mathias%2C+C+G%3BSinks%2C+TH%3BSeligman%2C+P+J%3BHalperin%2C+W+E&rft.aulast=Mathias&rft.aufirst=C&rft.date=1990-01-01&rft.volume=17&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational health; feasibility studies; statistics ER - TY - JOUR T1 - Origins of behavioral teratology and distinctions between research on pharmaceutical agents and environmental/industrial chemicals. AN - 15726207; 2350162 AB - Most behavioral teratology studies have focused on pharmaceutical agents. Investigations of developmental toxicity are lacking for the majority of the nearly 100,000 industrial chemicals currently in use. Only some three dozen chemicals have been examined for behavioral/neurochemical deviations in offspring following maternal exposures. Examination of industrial agents for developmental toxicity, therefore, remains a major public health need. Most developmental research addresses the effects of pharmaceutical agents, but these studies frequently do not address environmental/industrial concerns due to fundamental differences in experimental methodology. The route, duration, and timing of exposure, usefulness of fostering of offspring, and potential concomitant exposure of both parents are all variables which should be treated differently in research on industrial chemicals as opposed to pharmaceutical agents. JF - Neurotoxicology and Teratology AU - Nelson, B K AD - Div. Biomed. and Behav. Sci., NIOSH, 4676 Columbia Parkway, C-24, Cincinnati, OH 45226, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 301 EP - 305 VL - 12 IS - 4 SN - 0892-0362, 0892-0362 KW - behaviour KW - teratology KW - Pollution Abstracts; Health & Safety Science Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - xenobiotics KW - solvents KW - reviews KW - teratogenesis KW - pharmacokinetics KW - H SI6.14:RESEARCH METHODOLOGY KW - N3 11101:General KW - X 24250:Reviews KW - P 6000:TOXICOLOGY AND HEALTH KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15726207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Origins+of+behavioral+teratology+and+distinctions+between+research+on+pharmaceutical+agents+and+environmental%2Findustrial+chemicals.&rft.au=Nelson%2C+B+K&rft.aulast=Nelson&rft.aufirst=B&rft.date=1990-01-01&rft.volume=12&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - xenobiotics; reviews; teratogenesis; pharmacokinetics; solvents; teratology ER - TY - JOUR T1 - Ureaplasma felinum sp. nov. and Ureaplasma cati sp. nov. isolated from the oral cavities of cats. AN - 15676254; 2304714 AB - Seven ureaplasma strains isolated from the oral cavities of domestic cast (Felis domestica ) were characterized and compared with the type strains of the three previously established species of this genus, Ureaplasma urealyticum (humans), Ureaplasma diversum (cattle), and Ureaplasma gallorale (chickens). The feline strains hydrolyzed urea but not arginine or glucose, were membrane bound, lacked cell walls, passed through 0.45- mu m membrane filters, required cholesterol for growth, and formed minute colonies on agar medium. The seven feline strains fell into two distinct groups based on (i) their antigenic properties, (ii) their genomic properties, and (iii) their polypeptide profiles. JF - International Journal of Systematic Bacteriology AU - Harasawa, R AU - Imada, Y AU - Ito, M AU - Koshimizu, K AU - Cassell, G H AU - Barile, M F AD - Lab. Mycoplasma, FDA, Bethesda, MD 20892, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 45 EP - 51 VL - 40 IS - 1 SN - 0020-7713, 0020-7713 KW - Ureaplasma felinum KW - isolation KW - strains KW - Ureaplasma cati KW - cats KW - Microbiology Abstracts B: Bacteriology KW - nucleotide sequence KW - antigenic characteristics KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15676254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+Bacteriology&rft.atitle=Ureaplasma+felinum+sp.+nov.+and+Ureaplasma+cati+sp.+nov.+isolated+from+the+oral+cavities+of+cats.&rft.au=Harasawa%2C+R%3BImada%2C+Y%3BIto%2C+M%3BKoshimizu%2C+K%3BCassell%2C+G+H%3BBarile%2C+M+F&rft.aulast=Harasawa&rft.aufirst=R&rft.date=1990-01-01&rft.volume=40&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+Bacteriology&rft.issn=00207713&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - antigenic characteristics; nucleotide sequence ER - TY - JOUR T1 - DNA relatedness among established Ureaplasma species and unidentified feline and canine serogroups. AN - 15658726; 2304096 AB - The levels of DNA relatedness among two unclassified feline ureaplasma serogroups, four unclassified canine ureaplasma serogroups, and the three previously established Ureaplasma species were examined and compared. The strains examined included five feline strains representing two feline serogroups, four canine strains representing four canine serogroups, and the type strains of the three established species. Each strain representing each species or serogroup exhibited 78% or more actual DNA homology with its homologous DNA, but less than 10% DNA homology with DNAs from the heterologous strains. These findings indicate that each of these human, bovine, avian, feline, and canine strains is genomically distinct. JF - International Journal of Systematic Bacteriology AU - Harasawa, R AU - Stephens, E B AU - Koshimizu, K AU - Pan, I-J AU - Barile, M F AD - Lab. Mycoplasma, Cent. Biol. Eval. Res., FDA, Bethesda, MD 20892, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 52 EP - 55 VL - 40 IS - 1 SN - 0020-7713, 0020-7713 KW - Ureaplasma KW - serotypes KW - homology KW - antigenic relationship KW - strains KW - Microbiology Abstracts B: Bacteriology KW - hybridization analysis KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15658726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+Bacteriology&rft.atitle=DNA+relatedness+among+established+Ureaplasma+species+and+unidentified+feline+and+canine+serogroups.&rft.au=Harasawa%2C+R%3BStephens%2C+E+B%3BKoshimizu%2C+K%3BPan%2C+I-J%3BBarile%2C+M+F&rft.aulast=Harasawa&rft.aufirst=R&rft.date=1990-01-01&rft.volume=40&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+Bacteriology&rft.issn=00207713&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - hybridization analysis ER - TY - JOUR T1 - A flexibility intervention to reduce the incidence and severity of joint injuries among municipal firefighters. AN - 15647987; 2292201 AB - The present study of 469 municipal firefighters examined the effect of flexibility training on the incidence and severity of joint injuries. Both flexibility measures and costs (lost time and medical care costs) were investigated in this study. Significant differences were found in flexibility scores of the experimental and control subjects with overall flexibility increased in the experimental group. Although incidence of injury was not significantly different for the experimental and control groups, injuries sustained by the experimental group resulted in significantly less lost time costs. Findings indicate that the flexibility training program had a beneficial effect on reducing the severity and costs of joint injuries in this firefighter population. JF - J. OCCUP. MED. AU - Hilyer, J C AU - Brown, K C AU - Sirles, A T AU - Peoples, L AD - NIOSH Deep South Cent. Occup. Saf. and Health, Univ. Alabama Sch. Nurs., Univ. Alabama, UAB Station, Birmingham, AL 35294, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 631 EP - 637 VL - 32 IS - 7 SN - 0096-1736, 0096-1736 KW - firefighter services KW - joint injuries KW - Health & Safety Science Abstracts KW - occupational safety KW - training KW - economics KW - H SM9.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - H SE8.28:FIREFIGHTER SERVICES AND SAFETY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15647987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=A+flexibility+intervention+to+reduce+the+incidence+and+severity+of+joint+injuries+among+municipal+firefighters.&rft.au=Hilyer%2C+J+C%3BBrown%2C+K+C%3BSirles%2C+A+T%3BPeoples%2C+L&rft.aulast=Hilyer&rft.aufirst=J&rft.date=1990-01-01&rft.volume=32&rft.issue=7&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - training; economics; occupational safety ER - TY - JOUR T1 - Sodium pentosan polysulfate (PPS), an anti-HIV agent also exhibits synergism with AZT, lymphoproliferative activity, and virus enhancement. AN - 15625958; 2277816 AB - Sodium pentosan polysulfate (PPS), a negatively charged polymer of beta -D-xylopyranose units, was evaluated for its anti-HIV effects in normal human peripheral mononuclear cells (PMNC) and its possible synergism with AZT. In the presence of 25 nM AZT, 2.0 mu g/ml of PPS reduced HIV-1 replication 110-fold, compared with a 3.9- and 7-fold decrease in the presence of either drug individually. Surprisingly, at low concentrations of either PPS or dextran sulfate, an enhancement of virus production was observed. PPS was nontoxic, had a proliferative effect on uninfected and a protective effect on infected PMNC. Virus enhancement at low concentrations of PPS appeared to be linked to its lymphoproliferative effect. These findings suggest that the use of PPS and others such agents as monotherapy for AIDS might have deleterious effects. However, due to its marked synergism with AZT and its lymphoproliferative activities, PPS might prove to be a useful agent in therapeutic trials of AIDS if used in combination with less than the usual dosage of AZT. JF - AIDS Research and Human Retroviruses AU - Anand, R AU - Nayyar, S AU - Galvin, T A AU - Merril, C R AU - Bigelow, L B AD - Retrovirus Res. Lab., CBER/FDA, Build. 29A, 8800 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 679 EP - 689 VL - 6 IS - 5 SN - 0889-2229, 0889-2229 KW - human immunodeficiency virus KW - 3'-azido 3'-deoxythymidine KW - treatment KW - sodium pentosan polysulfate KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - replication KW - synergism KW - V 22002:AIDS: Molecular and in vitro aspects KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15625958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Research+and+Human+Retroviruses&rft.atitle=Sodium+pentosan+polysulfate+%28PPS%29%2C+an+anti-HIV+agent+also+exhibits+synergism+with+AZT%2C+lymphoproliferative+activity%2C+and+virus+enhancement.&rft.au=Anand%2C+R%3BNayyar%2C+S%3BGalvin%2C+T+A%3BMerril%2C+C+R%3BBigelow%2C+L+B&rft.aulast=Anand&rft.aufirst=R&rft.date=1990-01-01&rft.volume=6&rft.issue=5&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=AIDS+Research+and+Human+Retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - synergism; replication ER - TY - JOUR T1 - Developmental toxicology assessment of 1-octanol, 1-nonanol, and 1-decanol administered by inhalation to rats. AN - 15596172; 2240115 AB - As part of a large study evaluating the developmental toxicology of industrial alcohols administered by inhalation, groups of approximately 15 pregnant female Sprague-Dawley rats were exposed for 7 h/day on gestation days 1-19 (sperm = 0) to one of three long-chain alcohols at the maximum concentrations that could be generated as a vapor. These concentrations were 400 mg/m super(3) 1-octanol, 150 mg/m super(3) 1-nonanol, and 100 mg/m super(3) 1-decanol. Dams were weighed daily for the first week of exposure, and weekly thereafter. On destation day 20, rats were sacrificed. Fetuses were serially remove, blotted dry, examined for external malformations, sexed, weighed, placed in appropriate fixatives, and subsequently examined for visceral or skeletal abnormalities. No treatment-related effects were observed in pregnant females, frequency of resorptions, fetal weights, or skeletal/visceral malformations. Thus, long-chain alcohols at these vapor concentrations appear not to be toxic as evidenced by these fetal and maternal parameters. JF - Journal of the American College of Toxicology AU - Nelson, B K AU - Brightwell, W S AU - Khan, A AU - Krieg, EF Jr AU - Hoberman, A M AD - Div. Biomed. and Behav. Sci., NIOSH C-24, 4676 Columbia Pkwy., Cincinnati, OH 45226-1998, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 93 EP - 97 VL - 9 IS - 1 SN - 0730-0913, 0730-0913 KW - 1-octanol KW - development KW - teratogenesis KW - n-nonyl alcohol KW - n-decyl alcohol KW - rats KW - Pollution Abstracts; Toxicology Abstracts KW - inhalation KW - toxicity KW - teratogenicity KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15596172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Toxicology&rft.atitle=Developmental+toxicology+assessment+of+1-octanol%2C+1-nonanol%2C+and+1-decanol+administered+by+inhalation+to+rats.&rft.au=Nelson%2C+B+K%3BBrightwell%2C+W+S%3BKhan%2C+A%3BKrieg%2C+EF+Jr%3BHoberman%2C+A+M&rft.aulast=Nelson&rft.aufirst=B&rft.date=1990-01-01&rft.volume=9&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Toxicology&rft.issn=07300913&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - inhalation; toxicity; rats; teratogenicity ER - TY - PAT T1 - IgE Fc directed delivery system. AN - 15414202; 2162283 AB - The authors describe a method of detecting mast cell tumors, benign mastocytosis or mast cell number comprising systemically delivering an effective amount of a conjugate of IgE Fc and a radiolabeled agent to a host suspected of having a mast cell tumor, benign mastocytosis or disease process involving mast cells, and obtaining a radiographic image of said host or of a body part thereof. AU - Kaliner, MA AU - Boltansky, H PY - 1990 IS - US Patent 4,902,495 KW - immunoglobulin E KW - detection KW - binding KW - conjugates KW - Fc receptors KW - immunotoxins KW - mast cells KW - patents KW - tumours KW - Biotechnology and Bioengineering Abstracts KW - W 30506:Therapeutic KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15414202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=IgE+Fc+directed+delivery+system.&rft.au=Kaliner%2C+MA%3BBoltansky%2C+H&rft.aulast=Kaliner&rft.aufirst=MA&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 424-1.1; Int. Cl. A61K 49/02, 39/395. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519945223 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 1 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519945153 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519944915 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Back Matter AN - 1519944372 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 2 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Front Matter AN - 1519944328 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 4 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Unindexed Middle Matter AN - 1519944268 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 24 Years of Potential Life Lost and Other Trends in Alcohol-Related Fatal Traffic Crashes: 1977-1987 AN - 1474334614 JF - Alcohol Health and Research World AU - Zobeck, Terry S AU - Williams, Gerald D AU - Grant, Bridget F AU - Bertolucci, Darryl Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 63 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+24+Years+of+Potential+Life+Lost+and+Other+Trends+in+Alcohol-Related+Fatal+Traffic+Crashes%3A+1977-1987&rft.au=Zobeck%2C+Terry+S%3BWilliams%2C+Gerald+D%3BGrant%2C+Bridget+F%3BBertolucci%2C+Darryl&rft.aulast=Zobeck&rft.aufirst=Terry&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Use of Laws to Deter Drinking and Driving AN - 1474334523 JF - Alcohol Health and Research World AU - Hingson, Ralph AU - Howland, Jonathan Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 36 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Use+of+Laws+to+Deter+Drinking+and+Driving&rft.au=Hingson%2C+Ralph%3BHowland%2C+Jonathan&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Highlights of the Proceedings of the Surgeon General's Workshop on Drunk Driving AN - 1474334416 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 5 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Highlights+of+the+Proceedings+of+the+Surgeon+General%27s+Workshop+on+Drunk+Driving&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and the Brain AN - 1474334370 JF - Alcohol Health and Research World AU - Charness, Michael E Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 85 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+the+Brain&rft.au=Charness%2C+Michael+E&rft.aulast=Charness&rft.aufirst=Michael&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Pharmacologic Approaches to Alcoholism Treatment AN - 1474322005 JF - Alcohol Health and Research World AU - Liebowitz, Neil R AU - Kranzler, Henry R AU - Meyer, Roger E Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 144 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474322005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Pharmacologic+Approaches+to+Alcoholism+Treatment&rft.au=Liebowitz%2C+Neil+R%3BKranzler%2C+Henry+R%3BMeyer%2C+Roger+E&rft.aulast=Liebowitz&rft.aufirst=Neil&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Drinking and Driving: Beyond the Criminal Approach AN - 1474321959 JF - Alcohol Health and Research World AU - Ross, H Laurence Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 58 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Drinking+and+Driving%3A+Beyond+the+Criminal+Approach&rft.au=Ross%2C+H+Laurence&rft.aulast=Ross&rft.aufirst=H&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Control of Alcohol-Involved Driving Through Impersonal Prevention AN - 1474321903 JF - Alcohol Health and Research World AU - Phelps, Charles E Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 52 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Control+of+Alcohol-Involved+Driving+Through+Impersonal+Prevention&rft.au=Phelps%2C+Charles+E&rft.aulast=Phelps&rft.aufirst=Charles&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Brain-Imaging Tools for the Study of Alcoholism AN - 1474321872 JF - Alcohol Health and Research World AU - Pfefferbaum, Adolf AU - Rosenbloom, Margaret J Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 219 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Brain-Imaging+Tools+for+the+Study+of+Alcoholism&rft.au=Pfefferbaum%2C+Adolf%3BRosenbloom%2C+Margaret+J&rft.aulast=Pfefferbaum&rft.aufirst=Adolf&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Genetic Animal Models AN - 1474321824 JF - Alcohol Health and Research World AU - Crabbe, John C AU - Phillips, Tamara J Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 179 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Genetic+Animal+Models&rft.au=Crabbe%2C+John+C%3BPhillips%2C+Tamara+J&rft.aulast=Crabbe&rft.aufirst=John&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Liver-Brain Relations in Alcoholics AN - 1474321788 JF - Alcohol Health and Research World AU - Arria, Amelia M AU - Tarter, Ralph E AU - THIEL, DAVID H. VAN Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 112 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Liver-Brain+Relations+in+Alcoholics&rft.au=Arria%2C+Amelia+M%3BTarter%2C+Ralph+E%3BTHIEL%2C+DAVID+H.+VAN&rft.aulast=Arria&rft.aufirst=Amelia&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Hypertension AN - 1474321753 JF - Alcohol Health and Research World AU - Friedman, Howard S Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 313 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Hypertension&rft.au=Friedman%2C+Howard+S&rft.aulast=Friedman&rft.aufirst=Howard&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Behavioral Animal Models in Alcohol Abuse Research AN - 1474321752 JF - Alcohol Health and Research World AU - Grant, Kathleen A Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 187 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Behavioral+Animal+Models+in+Alcohol+Abuse+Research&rft.au=Grant%2C+Kathleen+A&rft.aulast=Grant&rft.aufirst=Kathleen&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Treatment Versus Deterrence AN - 1474321751 JF - Alcohol Health and Research World AU - Nichols, James L Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 44 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Treatment+Versus+Deterrence&rft.au=Nichols%2C+James+L&rft.aulast=Nichols&rft.aufirst=James&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Fatty Acid Ethyl Esters and Heart Disease AN - 1474321730 JF - Alcohol Health and Research World AU - Bora, Puran S AU - Lange, Louis G Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 285 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Fatty+Acid+Ethyl+Esters+and+Heart+Disease&rft.au=Bora%2C+Puran+S%3BLange%2C+Louis+G&rft.aulast=Bora&rft.aufirst=Puran&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Interactions Between Alcohol and Cardiovascular Medications AN - 1474321720 JF - Alcohol Health and Research World AU - Thomas, Barbara A AU - Regan, Timothy J Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 333 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Interactions+Between+Alcohol+and+Cardiovascular+Medications&rft.au=Thomas%2C+Barbara+A%3BRegan%2C+Timothy+J&rft.aulast=Thomas&rft.aufirst=Barbara&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Nervous System and the Predisposition to Alcoholism AN - 1474321627 JF - Alcohol Health and Research World AU - CONNOR, SEAN O' AU - Hesselbrock, Victor AU - Bauer, Lance Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 90 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Nervous+System+and+the+Predisposition+to+Alcoholism&rft.au=CONNOR%2C+SEAN+O%27%3BHesselbrock%2C+Victor%3BBauer%2C+Lance&rft.aulast=CONNOR&rft.aufirst=SEAN&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol, Stroke, and the Cerebral Circulation AN - 1474321601 JF - Alcohol Health and Research World AU - Altura, Burton M AU - Altura, Bella T Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 322 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol%2C+Stroke%2C+and+the+Cerebral+Circulation&rft.au=Altura%2C+Burton+M%3BAltura%2C+Bella+T&rft.aulast=Altura&rft.aufirst=Burton&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - International Perspectives Random Breath Testing the Australian Way: A Model for the United States? AN - 1474321591 JF - Alcohol Health and Research World AU - Homel, Ross J Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 70 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=International+Perspectives+Random+Breath+Testing+the+Australian+Way%3A+A+Model+for+the+United+States%3F&rft.au=Homel%2C+Ross+J&rft.aulast=Homel&rft.aufirst=Ross&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Biochemical Markers of Alcohol Consumption AN - 1474321579 JF - Alcohol Health and Research World AU - Rosman, Alan S AU - Lieber, Charles S Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 210 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Biochemical+Markers+of+Alcohol+Consumption&rft.au=Rosman%2C+Alan+S%3BLieber%2C+Charles+S&rft.aulast=Rosman&rft.aufirst=Alan&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Special Populations Alcohol, Women, and Heart Disease AN - 1474321562 JF - Alcohol Health and Research World AU - Doria, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 349 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Special+Populations+Alcohol%2C+Women%2C+and+Heart+Disease&rft.au=Doria%2C+John&rft.aulast=Doria&rft.aufirst=John&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Advances in Neurochemistry: A Leading Edge of Alcohol Research AN - 1474321557 JF - Alcohol Health and Research World AU - Tabakoff, Boris AU - Hoffman, Paula L AU - Petersen, Robert C Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 138 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Advances+in+Neurochemistry%3A+A+Leading+Edge+of+Alcohol+Research&rft.au=Tabakoff%2C+Boris%3BHoffman%2C+Paula+L%3BPetersen%2C+Robert+C&rft.aulast=Tabakoff&rft.aufirst=Boris&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Severe Brain Dysfunction: Alcoholic Korsakoff's Syndrome AN - 1474321534 JF - Alcohol Health and Research World AU - Berman, Marlene Oscar Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 120 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Severe+Brain+Dysfunction%3A+Alcoholic+Korsakoff%27s+Syndrome&rft.au=Berman%2C+Marlene+Oscar&rft.aulast=Berman&rft.aufirst=Marlene&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Importance of Animal Research to Alcoholism Treatment and Prevention AN - 1474321528 JF - Alcohol Health and Research World AU - Deitrich, Richard A Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 176 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Importance+of+Animal+Research+to+Alcoholism+Treatment+and+Prevention&rft.au=Deitrich%2C+Richard+A&rft.aulast=Deitrich&rft.aufirst=Richard&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Drinking and Driving in America: Disturbing Facts - Encouraging Reductions AN - 1474321509 JF - Alcohol Health and Research World AU - Fell, James C Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 18 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Drinking+and+Driving+in+America%3A+Disturbing+Facts+-+Encouraging+Reductions&rft.au=Fell%2C+James+C&rft.aulast=Fell&rft.aufirst=James&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474321504 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 267 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Consumption and Hypertension: A Collaborative Study AN - 1474321496 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 320 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Consumption+and+Hypertension%3A+A+Collaborative+Study&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol Reinforcement: Complex Determinant of Drinking AN - 1474321440 JF - Alcohol Health and Research World AU - Lewis, Michael J AU - LOCKMULLER, JANE C Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 98 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+Reinforcement%3A+Complex+Determinant+of+Drinking&rft.au=Lewis%2C+Michael+J%3BLOCKMULLER%2C+JANE+C&rft.aulast=Lewis&rft.aufirst=Michael&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Clinical Diagnostic Techniques and Assessment Tools in Alcohol Research AN - 1474321432 JF - Alcohol Health and Research World AU - Maisto, Stephen A AU - Connors, Gerard J Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 232 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Clinical+Diagnostic+Techniques+and+Assessment+Tools+in+Alcohol+Research&rft.au=Maisto%2C+Stephen+A%3BConnors%2C+Gerard+J&rft.aulast=Maisto&rft.aufirst=Stephen&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Cardiovascular Disease AN - 1474321379 JF - Alcohol Health and Research World AU - Lands, William E M AU - ZAKHARI, SAMIR Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 304 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Cardiovascular+Disease&rft.au=Lands%2C+William+E+M%3BZAKHARI%2C+SAMIR&rft.aulast=Lands&rft.aufirst=William+E&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Effects of Alcohol on Driving Performance AN - 1474321341 JF - Alcohol Health and Research World AU - Moskowitz, Herbert AU - Burns, Marcelline Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 12 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Effects+of+Alcohol+on+Driving+Performance&rft.au=Moskowitz%2C+Herbert%3BBurns%2C+Marcelline&rft.aulast=Moskowitz&rft.aufirst=Herbert&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol-Drug Interactions: Perspectives on Research and Prevention An Interview with Markku Linnoila AN - 1474321285 JF - Alcohol Health and Research World AU - Doria, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 15 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol-Drug+Interactions%3A+Perspectives+on+Research+and+Prevention+An+Interview+with+Markku+Linnoila&rft.au=Doria%2C+John&rft.aulast=Doria&rft.aufirst=John&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Animal Models as Tools in Alcohol Research: An Overview AN - 1474321193 JF - Alcohol Health and Research World AU - Crabbe, John C Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 178 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Animal+Models+as+Tools+in+Alcohol+Research%3A+An+Overview&rft.au=Crabbe%2C+John+C&rft.aulast=Crabbe&rft.aufirst=John&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Molecular Cloning in Alcohol Research AN - 1474321158 JF - Alcohol Health and Research World AU - Crabb, David W Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 197 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Molecular+Cloning+in+Alcohol+Research&rft.au=Crabb%2C+David+W&rft.aulast=Crabb&rft.aufirst=David&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Use of Computer Simulation in Genetic Linkage Studies AN - 1474321130 JF - Alcohol Health and Research World AU - Rice, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 253 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474321130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Use+of+Computer+Simulation+in+Genetic+Linkage+Studies&rft.au=Rice%2C+John&rft.aulast=Rice&rft.aufirst=John&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Computers in Prevention Research AN - 1474317814 JF - Alcohol Health and Research World AU - Holder, Harold D AU - Doria, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 246 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Computers+in+Prevention+Research&rft.au=Holder%2C+Harold+D%3BDoria%2C+John&rft.aulast=Holder&rft.aufirst=Harold&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Electronic Information Retrieval in Alcohol Research: An Overview AN - 1474317653 JF - Alcohol Health and Research World AU - Weglarz, Catherine AU - Page, Penny Booth Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 258 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Electronic+Information+Retrieval+in+Alcohol+Research%3A+An+Overview&rft.au=Weglarz%2C+Catherine%3BPage%2C+Penny+Booth&rft.aulast=Weglarz&rft.aufirst=Catherine&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Computers in Alcohol Research: An Overview AN - 1474317637 JF - Alcohol Health and Research World AU - Doria, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 245 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Computers+in+Alcohol+Research%3A+An+Overview&rft.au=Doria%2C+John&rft.aulast=Doria&rft.aufirst=John&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcoholic Cardiomyopathy: Clinical, Pathological, and Experimental Aspects AN - 1474317610 JF - Alcohol Health and Research World AU - Rubin, Emanuel AU - Doria, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 277 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcoholic+Cardiomyopathy%3A+Clinical%2C+Pathological%2C+and+Experimental+Aspects&rft.au=Rubin%2C+Emanuel%3BDoria%2C+John&rft.aulast=Rubin&rft.aufirst=Emanuel&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474317522 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 3 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Cognitive-Processing Deficits in Chronic Alcohol Abusers AN - 1474317491 JF - Alcohol Health and Research World AU - Cermak, Laird S Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 130 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Cognitive-Processing+Deficits+in+Chronic+Alcohol+Abusers&rft.au=Cermak%2C+Laird+S&rft.aulast=Cermak&rft.aufirst=Laird&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - General Glossary AN - 1474317431 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 302 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=General+Glossary&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 25 Alcohol Consumption in a 1986 Sample of Deaths AN - 1474317379 JF - Alcohol Health and Research World AU - Stinson, Frederick S AU - Parrish, Kiyoko AU - Noble, John Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 154 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+25+Alcohol+Consumption+in+a+1986+Sample+of+Deaths&rft.au=Stinson%2C+Frederick+S%3BParrish%2C+Kiyoko%3BNoble%2C+John&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Controlled Clinical Trials AN - 1474317360 JF - Alcohol Health and Research World AU - Fuller, Richard K Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 239 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Controlled+Clinical+Trials&rft.au=Fuller%2C+Richard+K&rft.aulast=Fuller&rft.aufirst=Richard&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Research Report Institute of Medicine Report "Prevention and Treatment of Alcohol Problems: Research Opportunities" AN - 1474317310 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 164 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Research+Report+Institute+of+Medicine+Report+%22Prevention+and+Treatment+of+Alcohol+Problems%3A+Research+Opportunities%22&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Value of Animals in Alcohol-Related Research AN - 1474317280 JF - Alcohol Health and Research World AU - Goodwin, Frederick K Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 173 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Value+of+Animals+in+Alcohol-Related+Research&rft.au=Goodwin%2C+Frederick+K&rft.aulast=Goodwin&rft.aufirst=Frederick&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - The Processes of Alcohol Tolerance and Dependence AN - 1474317273 JF - Alcohol Health and Research World AU - HARRIS, R ADRON AU - Buck, Kari J Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 105 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Processes+of+Alcohol+Tolerance+and+Dependence&rft.au=HARRIS%2C+R+ADRON%3BBuck%2C+Kari+J&rft.aulast=HARRIS&rft.aufirst=R&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Alcohol and Coronary Artery Disease AN - 1474317226 JF - Alcohol Health and Research World AU - Klatsky, Arthur L Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 289 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Coronary+Artery+Disease&rft.au=Klatsky%2C+Arthur+L&rft.aulast=Klatsky&rft.aufirst=Arthur&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Introduction to the Cardiovascular System AN - 1474317206 JF - Alcohol Health and Research World AU - Chung, Mina K AU - Rich, Michael W Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 269 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Introduction+to+the+Cardiovascular+System&rft.au=Chung%2C+Mina+K%3BRich%2C+Michael+W&rft.aulast=Chung&rft.aufirst=Mina&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Epidemiologic Bulletin No. 26 Standardized Diagnostic Interviews for Alcohol Research AN - 1474317189 JF - Alcohol Health and Research World AU - Grant, Bridget F AU - Towle, Leland H Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 340 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 4 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+26+Standardized+Diagnostic+Interviews+for+Alcohol+Research&rft.au=Grant%2C+Bridget+F%3BTowle%2C+Leland+H&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=1990-01-01&rft.volume=14&rft.issue=4&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474317164 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 83 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 2 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - From the Editors AN - 1474317090 JF - Alcohol Health and Research World Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 171 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474317090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=From+the+Editors&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Special Populations Strategies to Reduce Youth Drinking and Driving AN - 1474316858 JF - Alcohol Health and Research World AU - Sweedler, Barry M Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 76 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Special+Populations+Strategies+to+Reduce+Youth+Drinking+and+Driving&rft.au=Sweedler%2C+Barry+M&rft.aulast=Sweedler&rft.aufirst=Barry&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Biochemical Markers of Predisposition to Alcoholism AN - 1474316852 JF - Alcohol Health and Research World AU - Pandey, Ghanshyam N Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 204 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Biochemical+Markers+of+Predisposition+to+Alcoholism&rft.au=Pandey%2C+Ghanshyam+N&rft.aulast=Pandey&rft.aufirst=Ghanshyam&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Who Are the Drinking Drivers? The Spectrum of Drinking Drivers Revisited AN - 1474316835 JF - Alcohol Health and Research World AU - Perrine, M W Bud Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 26 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 1 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Who+Are+the+Drinking+Drivers%3F+The+Spectrum+of+Drinking+Drivers+Revisited&rft.au=Perrine%2C+M+W+Bud&rft.aulast=Perrine&rft.aufirst=M+W&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Biochemical Tools in Alcohol Research: An Overview AN - 1474316820 JF - Alcohol Health and Research World AU - Lieber, Charles S Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 193 CY - Rockville PB - Public Health Service, National Institutes of Health VL - 14 IS - 3 SN - 0090-838X KW - Drug Abuse And Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474316820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Biochemical+Tools+in+Alcohol+Research%3A+An+Overview&rft.au=Lieber%2C+Charles+S&rft.aulast=Lieber&rft.aufirst=Charles&rft.date=1990-01-01&rft.volume=14&rft.issue=3&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-04-30 ER - TY - JOUR T1 - Determination of methoprene in water samples by high performance liquid chromatography AN - 13751907; 199004551 AB - Methoprene, a juvenile hormone analogue that could function as an insect growth regulator (larvicide), was detected in water samples at concentrations between 0.005 and 0.5 ug per ml. The method involved HPLC with a reversed-phase column (C-18) and UV detection at 255 nm. The standard curve was linear over the working concentration range. The detection limit for 5 ml samples was 2.5 ng per ml. Samples of aqueous methoprene were stable when stored at 4C for 3 weeks. JF - Journal of Liquid Chromatography AU - Allen, C R AU - Dickinson, C M AD - U.S. Department of Health and Human Services, Atlanta, Ga. Y1 - 1990 PY - 1990 DA - 1990 SP - 371 EP - 381 VL - 13 IS - 2 SN - 0148-3919, 0148-3919 KW - Columns KW - Insect KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13751907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Liquid+Chromatography&rft.atitle=Determination+of+methoprene+in+water+samples+by+high+performance+liquid+chromatography&rft.au=Allen%2C+C+R%3BDickinson%2C+C+M&rft.aulast=Allen&rft.aufirst=C&rft.date=1990-01-01&rft.volume=13&rft.issue=2&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Journal+of+Liquid+Chromatography&rft.issn=01483919&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Quantitative multiresidue analyses for volatile organics in water and milk, using a fused silica open-tubular wide-bore capillary column and automated headspace gas chromatography AN - 13745321; S199135615 AB - Solutions prepared by fortifying water and milk with volatile solvents such as acetone, methyl ethyl ketone, benzene, methylene chloride and chloroform commonly used in the manufacture of packaging material and adhesives, were analysed by this technique. Compounds were quantitated by the method of standard additions. An IBM System 9000 computer with the CAPMC3 chromatographic applications package and a BA-SIC linear regression program was used for data manipulation. The wide-bore fused silica open-tubular (FSOT) capillary columns showed improved detection capacities for certain compounds compared with normal-bore capillary GC columns. JF - Journal of Association of Official Analytical Chemists AU - McNeal, T P AU - Hollifield, H C AD - Food and Drug Administration, Washington, D.C. Y1 - 1990 PY - 1990 DA - 1990 SP - 328 EP - 331 VL - 73 IS - 2 KW - Analysis KW - Columns KW - Ibm KW - Methylene chloride KW - Methylethylketone KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13745321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Association+of+Official+Analytical+Chemists&rft.atitle=Quantitative+multiresidue+analyses+for+volatile+organics+in+water+and+milk%2C+using+a+fused+silica+open-tubular+wide-bore+capillary+column+and+automated+headspace+gas+chromatography&rft.au=McNeal%2C+T+P%3BHollifield%2C+H+C&rft.aulast=McNeal&rft.aufirst=T&rft.date=1990-01-01&rft.volume=73&rft.issue=2&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Journal+of+Association+of+Official+Analytical+Chemists&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Incidence of Vibrio parahaemolyticus in U.S. coastal waters and oysters AN - 13739866; 199100606 AB - Seawater and oysters were sampled 4 times during 1984-85 from 18 sites on the Pacific, Gulf and Atlantic U.S. coasts. Faecal coliform and aerobic plate counts were performed on samples, and virulence markers were assayed in confirmed Vibrio parahaemolyticus isolates by using a synthetic DNA probe and the KANAGAWA test. Mean density of V. parahaemolyticus, an enteric pathogen, was over 100 times greater in oysters than in water, whereas faecal coliform density was about 10 times greater in oysters. Water temperature was significantly correlated with V. parahaemolyticus density, with highest densities occurring during springtime and summer along the Gulf coast. Of the 2 isolates (out of 50) which hybridized with the DNA probe, only 1 was haemolytic in the Kanagawa test. JF - Applied and Environmental Microbiology AU - DePaola, A AU - Hopkins, L H AU - Peeler, J T AU - Wentz, B AU - McPhearson, R M AD - U.S. Food and Drug Administration, Dauphin Island, Ala. Y1 - 1990 PY - 1990 DA - 1990 SP - 2299 EP - 2302 VL - 56 IS - 8 SN - 0099-2240, 0099-2240 KW - Hybridized KW - Sea water (see also marine -----) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13739866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Incidence+of+Vibrio+parahaemolyticus+in+U.S.+coastal+waters+and+oysters&rft.au=DePaola%2C+A%3BHopkins%2C+L+H%3BPeeler%2C+J+T%3BWentz%2C+B%3BMcPhearson%2C+R+M&rft.aulast=DePaola&rft.aufirst=A&rft.date=1990-01-01&rft.volume=56&rft.issue=8&rft.spage=2299&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Polychlorinated dibenzofurans in the edible portion of selected fish AN - 13730556; 199101291 AB - Tabulated data are presented on the concentrations of polychlorinated dibenzofurans (PCDF) in edible tissues of 35 marine and freshwater fish, of different species, collected at different times from sites contaminated with industrial chemicals, or containing known or suspected amounts of polychlorinated biphenyls (PCB). The analytical procedures used are outlined. None of the fish contained more than 150 ppt of PCDF congeners; possible reasons for this are considered. The most commonly found compounds were 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran. JF - Chemosphere AU - Gardner, A M AD - Food and Drug Administration, Washington, D.C. Y1 - 1990 PY - 1990 DA - 1990 SP - 215 EP - 222 VL - 21 IS - 1/2 SN - 0045-6535, 0045-6535 KW - Analysis KW - Fish (see also individual groups listed below) KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13730556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Polychlorinated+dibenzofurans+in+the+edible+portion+of+selected+fish&rft.au=Gardner%2C+A+M&rft.aulast=Gardner&rft.aufirst=A&rft.date=1990-01-01&rft.volume=21&rft.issue=1%2F2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Visualization of interleukin-2-like molecules in MPP(+)-lesioned rat brain. AN - 79426264; 2610695 AB - The tissue distribution of interleukin-2 (IL-2) in normal and 1-methyl-4-phenyl-pyridinium (MPP+)-lesioned brains of rats was investigated. Intrastriatal administration of MPP+ caused visible damage in the vicinity of the injected region two weeks after injection. Autoradiography of the tissue section with anti-IL-2 antibodies plus trace amounts of radiolabeled IL-2 showed that the antibodies treatment elicited a selective radiolabeling of the brain tissues localized at the MPP(+)-lesioned region but not at normal cryo-sliced sections. Addition of radiolabeled IL-2 alone or normal rabbit immunoglobulins did not show any labeling effect. These autoradiographic imaging results suggest that there is an accumulation of cells bearing IL-2-like molecules at the MPP(+)-induced lesion sites. JF - Biochemical and biophysical research communications AU - Liang, S M AU - Liang, C M AU - Chiueh, C C AD - Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1989/12/29/ PY - 1989 DA - 1989 Dec 29 SP - 1312 EP - 1318 VL - 165 IS - 3 SN - 0006-291X, 0006-291X KW - Interleukin-2 KW - 0 KW - Receptors, Interleukin-2 KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Receptors, Interleukin-2 -- metabolism KW - Receptors, Interleukin-2 -- analysis KW - Autoradiography KW - Male KW - Parkinson Disease, Secondary -- metabolism KW - Parkinson Disease, Secondary -- chemically induced KW - Interleukin-2 -- metabolism KW - Interleukin-2 -- analysis KW - Brain Chemistry KW - Brain -- drug effects KW - Brain -- metabolism KW - 1-Methyl-4-phenylpyridinium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79426264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Visualization+of+interleukin-2-like+molecules+in+MPP%28%2B%29-lesioned+rat+brain.&rft.au=Liang%2C+S+M%3BLiang%2C+C+M%3BChiueh%2C+C+C&rft.aulast=Liang&rft.aufirst=S&rft.date=1989-12-29&rft.volume=165&rft.issue=3&rft.spage=1312&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-13 N1 - Date created - 1990-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anaphylactoid reactions reported after treatment with ciprofloxacin. AN - 79374924; 2596772 JF - Annals of internal medicine AU - Davis, H AU - McGoodwin, E AU - Reed, T G AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1989/12/15/ PY - 1989 DA - 1989 Dec 15 SP - 1041 EP - 1043 VL - 111 IS - 12 SN - 0003-4819, 0003-4819 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Product Surveillance, Postmarketing KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Anaphylaxis -- chemically induced KW - Drug Hypersensitivity -- etiology KW - Ciprofloxacin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79374924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Anaphylactoid+reactions+reported+after+treatment+with+ciprofloxacin.&rft.au=Davis%2C+H%3BMcGoodwin%2C+E%3BReed%2C+T+G&rft.aulast=Davis&rft.aufirst=H&rft.date=1989-12-15&rft.volume=111&rft.issue=12&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-12 N1 - Date created - 1990-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Study of the teratogenic potential of FD&C Red No. 40 when given in drinking water. AN - 79483633; 2626763 AB - FD&C Red No. 40 in the drinking water at a level of 0, 0.2, 0.4, or 0.7% was available ad libitum to female Osborne-Mendel rats throughout gestation. The treated females consumed 273.6, 545.7, and 939.3 mg FD&C Red No. 40 per kg body weight per day, respectively, for the three dose levels. The animals were sacrificed on gestation day 20. No fetal terata were seen. There were no dose-related changes in maternal findings, number of fetuses, fetal viability, or external or visceral variations. Skeletal development appeared similar to that of the control animals with the exception of the incidence of fetuses with reduced ossification of the hyoid, which was increased significantly at the 0.7% dose level. A dose-related increase occurred in the number of litters containing fetuses with at least two skeletal variations, but the numbers of litters with fetuses with at least one and at least three variations were not different from control values. JF - Toxicology and industrial health AU - Collins, T F AU - Black, T N AU - Welsh, J J AU - Brown, L H AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 937 EP - 948 VL - 5 IS - 6 SN - 0748-2337, 0748-2337 KW - Azo Compounds KW - 0 KW - Teratogens KW - Allura Red AC Dye KW - 25956-17-6 KW - Index Medicus KW - Rats KW - Drinking KW - Body Water -- drug effects KW - Weight Gain -- drug effects KW - Animals KW - Female KW - Pregnancy KW - Azo Compounds -- adverse effects KW - Azo Compounds -- administration & dosage KW - Abnormalities, Drug-Induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79483633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Study+of+the+teratogenic+potential+of+FD%26amp%3BC+Red+No.+40+when+given+in+drinking+water.&rft.au=Collins%2C+T+F%3BBlack%2C+T+N%3BWelsh%2C+J+J%3BBrown%2C+L+H&rft.aulast=Collins&rft.aufirst=T&rft.date=1989-12-01&rft.volume=5&rft.issue=6&rft.spage=937&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Testicular effects of bis(2-methoxyethyl) ether in the adult male rat. AN - 79483024; 2626759 AB - The onset of testicular pathology in the rat and possible recovery over an 8-week period were evaluated after the administration of up to 20 daily oral doses of bis(2-methoxyethyl) ether (diglyme) at 5.1 mmol/kg bw (684 mg/kg bw). Primary and secondary spermatocyte degeneration and spermatidic giant cells were observed after six to eight treatments. In addition, the testes-to-body weight ratio was significantly reduced by the tenth day of treatment and continued to be depressed eight weeks after discontinuation of the treatment. Testicular LDH-X activity, a pachytene spermatocyte marker enzyme, was significantly decreased in animals by the eighteenth day of treatment with diglyme. JF - Toxicology and industrial health AU - Cheever, K L AU - Weigel, W W AU - Richards, D E AU - Lal, J B AU - Plotnick, H B AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, OH 45226. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1099 EP - 1109 VL - 5 IS - 6 SN - 0748-2337, 0748-2337 KW - Ethylene Glycols KW - 0 KW - Isoenzymes KW - Methyl Ethers KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - diglyme KW - M4BH3X0MVZ KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Administration, Oral KW - Animals KW - Seminiferous Tubules -- drug effects KW - L-Lactate Dehydrogenase -- analysis KW - Body Weight -- drug effects KW - Male KW - Seminiferous Tubules -- pathology KW - Seminiferous Tubules -- enzymology KW - Organ Size -- drug effects KW - Methyl Ethers -- administration & dosage KW - Ethylene Glycols -- toxicity KW - Testis -- drug effects KW - Methyl Ethers -- toxicity KW - Testis -- pathology KW - Ethylene Glycols -- administration & dosage KW - Testis -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79483024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Testicular+effects+of+bis%282-methoxyethyl%29+ether+in+the+adult+male+rat.&rft.au=Cheever%2C+K+L%3BWeigel%2C+W+W%3BRichards%2C+D+E%3BLal%2C+J+B%3BPlotnick%2C+H+B&rft.aulast=Cheever&rft.aufirst=K&rft.date=1989-12-01&rft.volume=5&rft.issue=6&rft.spage=1099&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Developmental toxicity of urethan. AN - 79482102; 2697102 JF - Toxicology and industrial health AU - Collins, T F AU - Sotomayor, R E AD - Division of Toxicology, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1045 EP - 1060 VL - 5 IS - 6 SN - 0748-2337, 0748-2337 KW - Urethane KW - 3IN71E75Z5 KW - Index Medicus KW - Rats KW - Animals KW - Sex Factors KW - Cells, Cultured KW - Mice KW - Lung Neoplasms -- chemically induced KW - Abnormalities, Drug-Induced -- etiology KW - Species Specificity KW - Male KW - Female KW - Pregnancy KW - Cricetinae KW - Animals, Newborn KW - Maternal-Fetal Exchange -- drug effects KW - Urethane -- toxicity KW - Embryonic and Fetal Development -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79482102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Developmental+toxicity+of+urethan.&rft.au=Collins%2C+T+F%3BSotomayor%2C+R+E&rft.aulast=Collins&rft.aufirst=T&rft.date=1989-12-01&rft.volume=5&rft.issue=6&rft.spage=1045&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of chronic treatment and withdrawal of CNS depressants on aggressive behavior. AN - 79481481; 2560590 AB - Young adult CD-1 male mice were housed in individual cages throughout the study. Groups of 10 to 20 mice were given gradually increasing doses of delta-9-tetrahydrocannabinol (THC) at 6.25 to 25 mg/kg i.p., trifluoperazine (TFP) at 6 to 12 mg/kg p.o., phenobarbital sodium (PS) at 20 to 35 mg/kg p.o., morphine sulfate (MS) at 5 to 20 mg/kg i.p., methaqualone (MQ) 10 to 20 mg/kg p.o. or chlordiazepoxide (CDP) 10 to 25 mg/kg p.o. over four to six weeks to develop tolerance of these drugs. Following the development of tolerance, the drugs were withdrawn. On the fourth day of withdrawal, a young (3-4 weeks old) male mouse was introduced into the cage. When the intensity of the attack was measured by the percentage of animals that killed the intruder within four hours. The results indicated 0 to 4 percent in the controls, 50-54 percent for THC, 50 percent for TFP, 42 percent for PS and 57 percent for MS. In contrast, no killing behavior was exhibited by these mice after treatment with MQ or CDP. These data suggest that enhanced aggressive behavior, elicited by withdrawal from certain psychotropic drugs, may be measured by the killing (muricidal) behavior of isolated mice. JF - Toxicology and industrial health AU - Yen-Koo, H C AU - Tocus, E C AU - Balazs, T AD - Division of Drug Biology, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 953 EP - 956 VL - 5 IS - 6 SN - 0748-2337, 0748-2337 KW - Trifluoperazine KW - 214IZI85K3 KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Morphine KW - 76I7G6D29C KW - Dronabinol KW - 7J8897W37S KW - Methaqualone KW - 7ZKH8MQW6T KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Phenobarbital -- pharmacology KW - Chlordiazepoxide -- pharmacology KW - Phenobarbital -- adverse effects KW - Morphine -- adverse effects KW - Dose-Response Relationship, Drug KW - Mice KW - Methaqualone -- pharmacology KW - Methaqualone -- adverse effects KW - Male KW - Morphine -- pharmacology KW - Chlordiazepoxide -- adverse effects KW - Behavior, Animal -- drug effects KW - Aggression -- drug effects KW - Substance Withdrawal Syndrome KW - Trifluoperazine -- pharmacology KW - Dronabinol -- pharmacology KW - Trifluoperazine -- adverse effects KW - Dronabinol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79481481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=The+effects+of+chronic+treatment+and+withdrawal+of+CNS+depressants+on+aggressive+behavior.&rft.au=Yen-Koo%2C+H+C%3BTocus%2C+E+C%3BBalazs%2C+T&rft.aulast=Yen-Koo&rft.aufirst=H&rft.date=1989-12-01&rft.volume=5&rft.issue=6&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurochemical effects of prenatal haloperidol exposure. AN - 79475436; 2533691 AB - The neurochemical effects of prenatal exposure to dopamine receptor antagonists are as yet poorly characterized. To further examine this problem, pregnant rats were given daily subcutaneous injections of vehicle, 2.5 or 5.0 mg/kg haloperidol over gestational days 6 through 20. Membrane binding of [3H]SCH-23390 (D1-specific) and [3H]spiroperidol (D2-specific in most brain areas) was measured in four regions of the cerebral dopamine system at postnatal day (PND) 30. Dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were measured in caudate on PND 30 following a d-amphetamine challenge. Prenatal haloperidol exposure reduced [3H]SCH-23390 and [3H]spiroperidol binding in caudate in a dose-dependent manner. [3H]Spiroperidol binding was similarly reduced in nucleus accumbens, but only the low dose (2.5 mg/kg) group showed decreased [3H]SCH-23390 binding in this region. Binding of neither compound was significantly altered in amygdala or frontal cortex. Basal or drug-stimulated levels of caudate DA and DOPAC were unaltered. It is concluded that prenatal haloperidol exposure reduces D1 and D2 binding in some, but not all regions of the forebrain dopamine system. JF - Pharmacology, biochemistry, and behavior AU - Scalzo, F M AU - Holson, R R AU - Gough, B J AU - Ali, S F AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 721 EP - 725 VL - 34 IS - 4 SN - 0091-3057, 0091-3057 KW - Receptors, Dopamine KW - 0 KW - Receptors, Dopamine D1 KW - Receptors, Dopamine D2 KW - Amphetamine KW - CK833KGX7E KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Sex Factors KW - Body Weight -- drug effects KW - Male KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Receptors, Dopamine -- drug effects KW - Brain Chemistry -- drug effects KW - Haloperidol -- toxicity KW - Receptors, Dopamine -- metabolism KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79475436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Neurochemical+effects+of+prenatal+haloperidol+exposure.&rft.au=Scalzo%2C+F+M%3BHolson%2C+R+R%3BGough%2C+B+J%3BAli%2C+S+F&rft.aulast=Scalzo&rft.aufirst=F&rft.date=1989-12-01&rft.volume=34&rft.issue=4&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-27 N1 - Date created - 1990-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral effects of prenatal haloperidol exposure. AN - 79474662; 2623028 AB - Pregnant albino rats were exposed to vehicle (CON), 2.5 mg/kg (LOW) or 5.0 mg/kg (HIGH) haloperidol (HAL) from the sixth through the twentieth day of gestation. The effect of prenatal HAL exposure on offspring was assessed with the following five behavioral measures: 1) milk-induced behavioral activation on the sixth postnatal day (PND 6), 2) shock-precipitated wall climbing (PNDs 9, 11, 13, 15 and 17), 3) amphetamine-induced stereotypies (PND 30), 4) apomorphine-induced stereotypies (PND 30) and 5) duration of barbiturate anesthesia (PNDs 34 and 62). Measures taken very early in life indicated that prenatal HAL reduced arousal. Inactivity scores were elevated in HAL-exposed pups on PND 6 during milk-induced behavioral activation. Shock-precipitated wall climbing was reduced in the HAL animals on PNDs 9 and 11, but not thereafter. At PND 30, no prenatal treatment effect was detectable on stimulant-induced stereotypies or on duration of barbiturate anesthesia. On PND 62, barbiturate anesthesia duration was significantly reduced in both sexes of HIGH HAL animals. These findings suggest that prenatal HAL effects follow a dynamic, changing course as the exposed rat pup matures. Early reductions in arousal (milk-induced behavior and shock-precipitated wall climbing) wane with age, perhaps to be replaced by an actual increase in arousal as HAL pups approach adulthood. JF - Pharmacology, biochemistry, and behavior AU - Scalzo, F M AU - Ali, S F AU - Holson, R R AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 727 EP - 731 VL - 34 IS - 4 SN - 0091-3057, 0091-3057 KW - Pentobarbital KW - I4744080IR KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Conditioning, Operant -- drug effects KW - Animals KW - Anesthesia KW - Stereotyped Behavior -- drug effects KW - Avoidance Learning -- drug effects KW - Male KW - Female KW - Pregnancy KW - Behavior, Animal -- drug effects KW - Haloperidol -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79474662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Behavioral+effects+of+prenatal+haloperidol+exposure.&rft.au=Scalzo%2C+F+M%3BAli%2C+S+F%3BHolson%2C+R+R&rft.aulast=Scalzo&rft.aufirst=F&rft.date=1989-12-01&rft.volume=34&rft.issue=4&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-27 N1 - Date created - 1990-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lead poisoning among household members exposed to lead-acid battery repair shops in Kingston, Jamaica. AN - 79469400; 2621024 AB - To investigate the risk of lead poisoning among household members exposed to 'backyard' battery repair shops (BBRS) in Kingston, Jamaica, environmental and blood lead (PbB) were measured at 24 households (112 individuals) with a BBRS worker or located at a BBRS premises and at 18 neighbourhood control households (74 individuals). Elevated PbB (greater than or equal to 25 micrograms per decilitre [micrograms/dl]) was common among subjects of all ages living at BBRS premises, especially among children less than age 12, 43% of whom had PbB greater than 70 micrograms/dl. Potentially hazardous soil and house dust lead levels were also common at BBRS premises, where 84% of yards had soil lead levels above 500 parts per million (geometric mean 3388 parts per million [ppm] at BBRS premises households with a BBRS worker). Geometric mean blood and environmental lead levels were significantly lower at control households, where less than 10% of subjects in all age groups had elevated PbB (maximum 33 micrograms/dl). Sharing a premises with a BBRS was a stronger determinant of household blood lead and environmental contamination than was the presence of a BBRS worker in a household. Blood lead levels were associated with soil and house dust lead levels in all age groups. We conclude that small battery repair shops, which have also been described in other developing countries, create a high lead poisoning risk for nearby residents. JF - International journal of epidemiology AU - Matte, T D AU - Figueroa, J P AU - Ostrowski, S AU - Burr, G AU - Jackson-Hunt, L AU - Keenlyside, R A AU - Baker, E L AD - NIOSH/Centers for Disease Control, Atlanta, GA 30333. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 874 EP - 881 VL - 18 IS - 4 SN - 0300-5771, 0300-5771 KW - Dust KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Child KW - Jamaica KW - Dust -- adverse effects KW - Adolescent KW - Male KW - Lead -- blood KW - Female KW - Occupational Diseases -- blood KW - Lead Poisoning -- blood KW - Residence Characteristics -- statistics & numerical data KW - Lead Poisoning -- etiology KW - Automobiles KW - Occupational Diseases -- chemically induced KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79469400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Lead+poisoning+among+household+members+exposed+to+lead-acid+battery+repair+shops+in+Kingston%2C+Jamaica.&rft.au=Matte%2C+T+D%3BFigueroa%2C+J+P%3BOstrowski%2C+S%3BBurr%2C+G%3BJackson-Hunt%2C+L%3BKeenlyside%2C+R+A%3BBaker%2C+E+L&rft.aulast=Matte&rft.aufirst=T&rft.date=1989-12-01&rft.volume=18&rft.issue=4&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-23 N1 - Date created - 1990-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - High nutrient intakes--the toxicologist's view. AN - 79447171; 2693635 AB - At sufficiently high intake all substances, including essential nutrients, can be toxic. Toxicity may be described by characteristics of the symptoms (identity, severity and degree of persistence) and by the dose-response relationship (threshold, slope, limit, susceptibility to modulation by other substances and tendency to bioaccumulate). Some nutrient toxicities are deleterious exaggerations of essential functions, whereas others are not. The therapeutic indices for nutrients should be defined as the ratio of the lowest toxic dose to the recommended intake, the ratio of the medians of the effective and the toxic doses commonly used in pharmacology. For infant formulas, a ratio of the lowest toxic concentration to the maximum concentration allowed is an analogous ratio. Nutrients with low therapeutic indices and small physical size of a toxic dose require special caution to avoid excessive intake. Modulation of absorption, metabolism or excretion, as well as the physiological state of the exposed individual, may alter the minimum toxic intake of a nutrient and hence alter the risk of toxicity. Extrapolation to estimate the toxic dose can be made on the basis of body weight, body surface area or food intake. Nutrient minimums and maximums in infant formula are set on a 100-kcal basis and thus are related to heat loss and surface area. Evaluation of vitamin A toxicity cases on a dose per 100-kcal basis suggest that the current maximum in infant formula is appropriate. Extrapolation from toxicity data in adults can be made on the dose per 100-kcal basis to estimate appropriate infant formula maximums for nutrients for which maximums have not been set. JF - The Journal of nutrition AU - Hathcock, J N AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1779 EP - 1784 VL - 119 IS - 12 Suppl SN - 0022-3166, 0022-3166 KW - Index Medicus KW - Infant KW - Nutritional Requirements KW - Humans KW - Adult KW - Infant, Newborn KW - Toxicology KW - Male KW - Female KW - Infant Nutritional Physiological Phenomena KW - Infant Food -- poisoning KW - Energy Intake UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79447171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=High+nutrient+intakes--the+toxicologist%27s+view.&rft.au=Hathcock%2C+J+N&rft.aulast=Hathcock&rft.aufirst=J&rft.date=1989-12-01&rft.volume=119&rft.issue=12+Suppl&rft.spage=1779&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenicity study of 3,3'-dimethylbenzidine dihydrochloride in BALB/c mice. AN - 79417076; 2558063 AB - BALB/c mice (120/sex/dose) were given 0, 5, 9, 18, 35, 70 or 140 ppm of 3,3'-dimethylbenzidine dihydrochloride in their drinking-water and killed after 13, 26, 39, 52, 78 or 116 wk. Full histopathological evaluations were performed on all animals that were found dead or moribund, or that were killed on schedule. Fatal lung alveolar cell neoplasms began to appear in males receiving 140 ppm at 78 wk and there was a significant dose-related decrease in the time-to-death from this cause. There were no significant dose-related trends for this neoplasm in females, nor were there treatment-related effects on body weight, water consumption or other lesions in either sex. This is the first report of a neoplastic response to 3,3'-dimethylbenzidine dihydrochloride in mice. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Schieferstein, G J AU - Shinohara, Y AU - Allen, R R AU - Sheldon, W AU - Greenman, D L AU - Allaben, W T AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 801 EP - 806 VL - 27 IS - 12 SN - 0278-6915, 0278-6915 KW - Benzidines KW - 0 KW - Carcinogens KW - 2-tolidine KW - 63HLO2IV6K KW - Index Medicus KW - Animals KW - Sex Factors KW - Adenocarcinoma, Bronchiolo-Alveolar -- chemically induced KW - Random Allocation KW - Dose-Response Relationship, Drug KW - Skin Neoplasms -- chemically induced KW - Adenoma -- chemically induced KW - Mice KW - Lung Neoplasms -- chemically induced KW - Mice, Inbred BALB C KW - Time Factors KW - Male KW - Female KW - Benzidines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79417076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Carcinogenicity+study+of+3%2C3%27-dimethylbenzidine+dihydrochloride+in+BALB%2Fc+mice.&rft.au=Schieferstein%2C+G+J%3BShinohara%2C+Y%3BAllen%2C+R+R%3BSheldon%2C+W%3BGreenman%2C+D+L%3BAllaben%2C+W+T&rft.aulast=Schieferstein&rft.aufirst=G&rft.date=1989-12-01&rft.volume=27&rft.issue=12&rft.spage=801&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-14 N1 - Date created - 1990-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nonclinical pharmacologic and toxicologic considerations for evaluating biologic products. AN - 79397133; 2602582 AB - Prior to a Phase 1 clinical study, products are studied preclinically to establish evidence of pharmacologic activity, gain an understanding of the mechanism of action, evaluate the potential human risk, and establish a clinical study dose range. Although it is possible to follow this generic itinerary for the development of biologic products, it is difficult to develop generic protocols that will suffice for addressing these preclinical concerns for every biological product. Peptide hormones, cytokines, growth factors, vaccines, allergenics, plasma proteins, enzymes, toxins, monoclonal antibodies, and other heterologous antisera are unique in their physiological interactions, and therefore the toxicologic concerns and suggested studies are tailored to the uniqueness of the compound. This paper represents an attempt to share the thought processes that have been used at the Food and Drug Administration (FDA) to address the nonclinical pharmacology and toxicology study concerns. This presentation of considerations is based on an analysis of what has been done in recent years as a basis for initiating Phase 1 studies (first administration of drugs to humans) and progressing to Phase 2/3 studies (evaluation of optimal dose, effectiveness, and safety in humans), while I was Assistant Director (Pharmacology/Toxicology) of the Office of Biologics and since, as Assistant Director (Pharmacology/Toxicology) of the Office of Drug Evaluation II and a consultant to the Center for Biologics Evaluation and Research. JF - Regulatory toxicology and pharmacology : RTP AU - Weissinger, J AD - Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 255 EP - 263 VL - 10 IS - 3 SN - 0273-2300, 0273-2300 KW - Biological Products KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Risk Factors KW - Humans KW - Research Design KW - Drug Evaluation, Preclinical KW - Drugs, Investigational -- pharmacology KW - Biological Products -- toxicity KW - Biological Products -- pharmacology KW - Drugs, Investigational -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79397133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Nonclinical+pharmacologic+and+toxicologic+considerations+for+evaluating+biologic+products.&rft.au=Weissinger%2C+J&rft.aulast=Weissinger&rft.aufirst=J&rft.date=1989-12-01&rft.volume=10&rft.issue=3&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-05 N1 - Date created - 1990-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of aflatoxin B1 binding to hepatic DNA by dehydroepiandrosterone in vivo. AN - 79359851; 2531635 AB - Dehydroepiandrosterone (DHEA) a naturally occurring steroid, has been reported to inhibit the binding of N-dimethylnitrosamine and 7,12-dimethylbenz[a]anthracene to DNA in vivo and to increase glutathione transferase activity. In this study, we have investigated if DHEA could protect hepatic DNA from damage by the potent hepatocarcinogen aflatoxin B1 (AFB1). Young male Fischer 344 (2-month-old) rats were fed a diet containing 0.8% DHEA for 14 days. Control rats were pair-fed the same diet without DHEA. The rats were then administered a single i.p. dose of [3H]AFB1 in dimethylsulfoxide (0.6 mg/kg body weight; 200 mCi/mmol) and killed after 3 h. Liver weight, mitochondrial, microsomal and cytosolic protein, cytochrome P450 content and glutathione transferase activity increased significantly (P less than 0.001) in DHEA-fed rats; however, the hepatic DNA content was not altered. DHEA feeding increased the total amount of AFB1 bound to hepatic protein but decreased the extent of DNA binding. In in vitro experiments, there was less total binding to DNA and protein by AFB1 when using microsomes from DHEA-fed rats. These results suggest that DHEA inhibits the binding of AFB1 to DNA by modifying the biotransformation of the carcinogen. JF - Carcinogenesis AU - Prasanna, H R AU - Lu, M H AU - Beland, F A AU - Hart, R W AD - National Center for Toxicological Research, Jefferson, AR 72079-9502. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 2197 EP - 2200 VL - 10 IS - 12 SN - 0143-3334, 0143-3334 KW - Aflatoxins KW - 0 KW - Dehydroepiandrosterone KW - 459AG36T1B KW - DNA KW - 9007-49-2 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Rats KW - Animals KW - Reference Values KW - Rats, Inbred F344 KW - Subcellular Fractions -- metabolism KW - Protein Binding KW - Male KW - Aflatoxins -- pharmacokinetics KW - DNA -- isolation & purification KW - Aflatoxins -- metabolism KW - Liver -- drug effects KW - DNA -- metabolism KW - Liver -- metabolism KW - Dehydroepiandrosterone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79359851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+aflatoxin+B1+binding+to+hepatic+DNA+by+dehydroepiandrosterone+in+vivo.&rft.au=Prasanna%2C+H+R%3BLu%2C+M+H%3BBeland%2C+F+A%3BHart%2C+R+W&rft.aulast=Prasanna&rft.aufirst=H&rft.date=1989-12-01&rft.volume=10&rft.issue=12&rft.spage=2197&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-22 N1 - Date created - 1990-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isolation and characterization of an isogenic set of Salmonella typhimurium strains analogous to the "Ames" tester strains. AN - 79349228; 2685590 AB - The standard Ames tester strains of Salmonella typhimurium contain a number of genetic differences at loci other than his. The fact that these strains contain independently isolated uvrB-bio-gal deletions and rfa mutations implies that these are likely to vary from strain to strain. Since the strains were isolated from different parental stocks of S. typhimurium LT-2, they differ in their ability to metabolize arabinose. Other, unknown differences may exist because the isolation of some of the strains involved ultraviolet and chemical mutagenesis. We have isolated a set of isogenic S. typhimurium strains that contain the relevant genetic markers of the standard Ames tester strains. These strains all contain the same uvrB-bio-gal deletion and the same rfa mutation; they differ only in the nature of their his mutations and in the presence or absence of the plasmid pKM101. We have assessed the responsiveness of these strains to a number of mutagens and conclude that their mutagenic specificities are the same as those of the corresponding Ames strains: TA98, TA100, TA1535, TA1537 and TA1538. Therefore, the specificity of the standard Ames strains with respect to these mutagens is a result solely of the differences in the nature of their his mutations and the effects of pKM101. JF - Mutation research AU - Popkin, D J AU - Davis, V M AU - Prival, M J AD - Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 453 EP - 464 VL - 224 IS - 4 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Index Medicus KW - Phenotype KW - Genotype KW - Dose-Response Relationship, Drug KW - Mutagens -- pharmacology KW - Mutagenicity Tests -- methods KW - Salmonella typhimurium -- drug effects KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79349228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Isolation+and+characterization+of+an+isogenic+set+of+Salmonella+typhimurium+strains+analogous+to+the+%22Ames%22+tester+strains.&rft.au=Popkin%2C+D+J%3BDavis%2C+V+M%3BPrival%2C+M+J&rft.aulast=Popkin&rft.aufirst=D&rft.date=1989-12-01&rft.volume=224&rft.issue=4&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-03 N1 - Date created - 1990-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Observations on chromosome loss detection by multiple recessive marker expression in strain D61.M of Saccharomyces cerevisiae. AN - 79345443; 2685591 AB - Since chromosomes of fungi are difficult to observe directly, strains have been developed in which chromosome loss can be detected by the use of genetic markers. In the diploid D61.M strain of Saccharomyces cerevisiae, the loss of a copy of chromosome VII that carries 3 dominant wild-type alleles is measured by expression of 3 recessive mutant alleles carried on the other remaining copy of chromosome VII. We have tested the hypothesis that expression of the 3 recessive alleles might be due to 3 simultaneous independent genetic events other than chromosome loss, such as mutation or recombination. We have measured, when possible, the frequencies of expression for each of these recessive alleles, independently and in combination one with another, under both selective and non-selective conditions. Our results show that simultaneous expression of these 3 recessive alleles is attributable to chromosome loss (greater than 98%). Similarly, at least 99% of the nocodazole-induced events are attributable to chromosome loss. In contrast, most if not all of the apparent chromosome loss induced by ethyl methanesulfonate is due to multiple events of mutation or recombination. JF - Mutation research AU - Mayer, V W AU - Goin, C J AD - Division of Toxicological Studies, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 471 EP - 478 VL - 224 IS - 4 SN - 0027-5107, 0027-5107 KW - Genetic Markers KW - 0 KW - Cycloheximide KW - 98600C0908 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - Leucine KW - GMW67QNF9C KW - Adenine KW - JAC85A2161 KW - Nocodazole KW - SH1WY3R615 KW - Index Medicus KW - Ethyl Methanesulfonate -- pharmacology KW - Recombination, Genetic KW - Selection, Genetic KW - Nocodazole -- pharmacology KW - Genes, Recessive KW - Saccharomyces cerevisiae -- genetics KW - Chromosome Aberrations KW - Mutation KW - Saccharomyces cerevisiae -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79345443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Observations+on+chromosome+loss+detection+by+multiple+recessive+marker+expression+in+strain+D61.M+of+Saccharomyces+cerevisiae.&rft.au=Mayer%2C+V+W%3BGoin%2C+C+J&rft.aulast=Mayer&rft.aufirst=V&rft.date=1989-12-01&rft.volume=224&rft.issue=4&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-03 N1 - Date created - 1990-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of direct surveys in the surveillance of occupational illness and injury. AN - 79329240; 2817205 JF - American journal of public health AU - Ehrenberg, R L AD - National Institute for Occupational Safety and Health Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 12 EP - 14 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Wounds and Injuries -- epidemiology KW - Humans KW - National Center for Health Statistics (U.S.) KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Health Surveys KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79329240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Use+of+direct+surveys+in+the+surveillance+of+occupational+illness+and+injury.&rft.au=Ehrenberg%2C+R+L&rft.aulast=Ehrenberg&rft.aufirst=R&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1982 Dec;116(6):981-9 [6983296] Am J Ind Med. 1984;6(6):407-15 [6517070] N Engl J Med. 1963 Jan 24;268:182-92 [13928666] Am J Ind Med. 1988;13(1):5-41 [3344755] J Public Health Policy. 1988 Summer;9(2):198-221 [3417861] J Natl Cancer Inst. 1986 Oct;77(4):877-81 [3463819] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hazard surveillance at NIOSH. AN - 79328259; 2683818 JF - American journal of public health AU - Sundin, D S AU - Frazier, T M AD - National Institute for Occupational Safety and Health, Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 32 EP - 37 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Hazardous Substances KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - History of medicine KW - United States KW - National Institute for Occupational Safety and Health (U.S.) -- history KW - History, 20th Century KW - Humans KW - Occupational Diseases -- prevention & control KW - Environmental Monitoring -- history KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79328259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Hazard+surveillance+at+NIOSH.&rft.au=Sundin%2C+D+S%3BFrazier%2C+T+M&rft.aulast=Sundin&rft.aufirst=D&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Occup Health Saf. 1978 May-Jun;47(3):21-3 [652219] Am J Public Health. 1983 Sep;73(9):1054-62 [6881402] Scand J Work Environ Health. 1983 Apr;9(2 Spec No):148-54 [6648412] Am J Public Health. 1987 Oct;77(10):1310-4 [3631365] Am J Public Health. 1986 Sep;76(9):1083-4 [3740328] Am J Public Health. 1986 Sep;76(9):1089-96 [3740331] Annu Rev Public Health. 1985;6:419-32 [3994819] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surveillance in occupational illness and injury: concepts and content. AN - 79327908; 2817212 JF - American journal of public health AU - Baker, E L AU - Honchar, P A AU - Fine, L J AD - National Institute for Occupational Safety and Health Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 9 EP - 11 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Wounds and Injuries -- epidemiology KW - Humans KW - Death Certificates KW - United States Occupational Safety and Health Administration KW - Wounds and Injuries -- prevention & control KW - United States -- epidemiology KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods KW - Occupational Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79327908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Surveillance+in+occupational+illness+and+injury%3A+concepts+and+content.&rft.au=Baker%2C+E+L%3BHonchar%2C+P+A%3BFine%2C+L+J&rft.aulast=Baker&rft.aufirst=E&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1976 Mar;5(1):13-8 [770352] Am J Public Health. 1983 Sep;73(9):1054-62 [6881402] J Public Health Policy. 1988 Summer;9(2):198-221 [3417861] Am J Public Health. 1987 Aug;77(8):1006-8 [3605466] J Occup Med. 1986 Aug;28(8):547-52 [3746471] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The selection and definition of targeted work-related conditions for surveillance under SENSOR. AN - 79327871; 2554736 AB - Lists of reportable conditions and case definitions are important tools for epidemiologic surveillance. As part of an initiative to encourage occupational disease surveillance systems linked to intervention at the state level, we have proposed a list of target conditions and are developing a set of standard epidemiologic case definitions. Experience gained from state health department pilot projects using SENSOR and other surveillance approaches will be used to promote effective condition-specific surveillance strategies on a wider scale. JF - American journal of public health AU - Matte, T D AU - Baker, E L AU - Honchar, P A AD - National Institute for Occupational Safety and Health Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 21 EP - 25 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Carpal Tunnel Syndrome -- epidemiology KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Carpal Tunnel Syndrome -- prevention & control KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79327871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=The+selection+and+definition+of+targeted+work-related+conditions+for+surveillance+under+SENSOR.&rft.au=Matte%2C+T+D%3BBaker%2C+E+L%3BHonchar%2C+P+A&rft.aulast=Matte&rft.aufirst=T&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1976 Mar;5(1):13-8 [770352] N Engl J Med. 1980 Dec 18;303(25):1429-35 [7432401] Am Fam Physician. 1981 Nov;24(5):190-204 [6975030] Am J Public Health. 1983 Sep;73(9):1054-62 [6881402] Public Health Rep. 1983 Jul-Aug;98(4):324-36 [6310668] N Engl J Med. 1963 Jan 24;268:182-92 [13928666] Public Health Rep. 1984 Jan-Feb;99(1):31-5 [6422492] Am J Public Health. 1985 Dec;75(12):1420-2 [4061715] Am J Ind Med. 1987;11(3):343-58 [3578290] J Public Health Policy. 1988 Summer;9(2):198-221 [3417861] Am J Ind Med. 1983;4(5):661-81 [6624745] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development of a standard questionnaire for occupational health research. AN - 79326540; 2817206 AB - Direct surveys of groups of workers can provide valuable occupational health surveillance data, but this requires consistent collection of data. As part of efforts to improve the standardization of such methodology, NIOSH is developing a standard occupational health questionnaire. This questionnaire will be designed to collect demographic and occupational history information in addition to information about the presence of a spectrum of work-related conditions. The questionnaire will have a modular structure and will consist of a core questionnaire and a series of condition-specific modules. JF - American journal of public health AU - Ehrenberg, R L AU - Sniezek, J E AD - National Institute for Occupational Safety and Health Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 15 EP - 17 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Surveys and Questionnaires KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79326540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Development+of+a+standard+questionnaire+for+occupational+health+research.&rft.au=Ehrenberg%2C+R+L%3BSniezek%2C+J+E&rft.aulast=Ehrenberg&rft.aufirst=R&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1978 Dec;108(6):435-46 [736023] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Br J Ind Med. 1987 May;44(5):292-308 [3496112] J Occup Med. 1986 Oct;28(10):987-90 [3534164] Am J Public Health. 1983 Sep;73(9):1054-62 [6881402] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sentinel Event Notification System for Occupational Risks (SENSOR): the concept. AN - 79326415; 2817207 AB - Although many states have laws that require health providers to report cases of occupational illness and injury, most states do not maintain a comprehensive system that actively identifies and targets potential sources of case reports and then responds to such reports. NIOSH has developed a Sentinel Event Notification System for Occupational Risks (SENSOR) that uses targeted sources of sentinel providers to recognize and report selected occupational disorders to a state surveillance center. SENSOR is a cooperative state-federal effort designed to develop local capability for preventing selected occupational disorders. To demonstrate the feasibility of this approach, NIOSH initially funded seven SENSOR projects in 1987 and three additional projects in early 1988 (Table 1). Currently, these projects are in the preliminary stages of organization and start-up, with some having begun to receive case reports. As funds become available, NIOSH intends to gradually expand the scope of the program to include additional states over the next several years. JF - American journal of public health AU - Baker, E L AD - National Institute for Occupational Safety and Health Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 18 EP - 20 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Humans KW - United States -- epidemiology KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79326415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Sentinel+Event+Notification+System+for+Occupational+Risks+%28SENSOR%29%3A+the+concept.&rft.au=Baker%2C+E+L&rft.aulast=Baker&rft.aufirst=E&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1983 Mar 4;249(9):1181-5 [6823080] Am J Public Health. 1986 Nov;76(11):1285-6 [3766822] MMWR CDC Surveill Summ. 1987 Nov;36(2):7-12 [3119984] Int J Epidemiol. 1976 Mar;5(1):29-37 [944166] J Public Health Policy. 1988 Summer;9(2):198-221 [3417861] Int J Epidemiol. 1976 Mar;5(1):13-8 [770352] Am J Prev Med. 1986 Nov-Dec;2(6):345-50 [3453201] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surveillance in occupational health and safety. Challenges for the future. AN - 79325928; 2817211 JF - American journal of public health AU - Baker, E L AD - National Institute for Occupational Safety and Health, Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 61 EP - 63 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Forecasting KW - United States -- epidemiology KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79325928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Surveillance+in+occupational+health+and+safety.+Challenges+for+the+future.&rft.au=Baker%2C+E+L&rft.aulast=Baker&rft.aufirst=E&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surveillance for work-related adverse reproductive outcomes. AN - 79325908; 2817209 JF - American journal of public health AU - Bregman, D J AU - Anderson, K E AU - Buffler, P AU - Salg, J AD - National Institute for Occupational Safety and Health, Centers for Disease Control. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 53 EP - 57 VL - 79 Suppl SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - United States -- epidemiology KW - National Institute for Occupational Safety and Health (U.S.) KW - Reproduction KW - Occupational Diseases -- epidemiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79325908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Surveillance+for+work-related+adverse+reproductive+outcomes.&rft.au=Bregman%2C+D+J%3BAnderson%2C+K+E%3BBuffler%2C+P%3BSalg%2C+J&rft.aulast=Bregman&rft.aufirst=D&rft.date=1989-12-01&rft.volume=79+Suppl&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1981 Sep;10(3):247-52 [7287285] J Occup Med. 1982 Apr;24(4):305-14 [7069523] J Am Med Rec Assoc. 1988 Oct;59(10):28-33 [10290068] J Occup Med. 1985 May;27(5):379-85 [2989464] JAMA. 1984 Aug 17;252(7):903-12 [6748190] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mandatory reporting of occupational diseases by clinicians. AN - 79298496; 2810649 JF - JAMA AU - Freund, E AU - Seligman, P J AU - Chorba, T L AU - Safford, S K AU - Drachman, J G AU - Hull, H F AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1989/12/01/ PY - 1989 DA - 1989 Dec 01 SP - 3041 EP - 3044 VL - 262 IS - 21 SN - 0098-7484, 0098-7484 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Population Surveillance KW - Role KW - Public Health Administration KW - Physician's Role KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79298496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Mandatory+reporting+of+occupational+diseases+by+clinicians.&rft.au=Freund%2C+E%3BSeligman%2C+P+J%3BChorba%2C+T+L%3BSafford%2C+S+K%3BDrachman%2C+J+G%3BHull%2C+H+F&rft.aulast=Freund&rft.aufirst=E&rft.date=1989-12-01&rft.volume=262&rft.issue=21&rft.spage=3041&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative immunogenicities of Vi polysaccharide-protein conjugates composed of cholera toxin or its B subunit as a carrier bound to high- or lower-molecular-weight Vi. AN - 79283286; 2807549 AB - The effect of molecular weight or size of the components on the immunogenicity of polysaccharide-protein conjugates prepared with the native Vi capsular polysaccharide (Vi) (approximately 3 x 10(3) kilodaltons) or lower-molecular-weight Vi (Vis; approximately 46 kilodaltons) abound to cholera toxin (CT) or to its B subunit (CTB) was studied. In mice, Vi-CT, Vi-CTB, and Vis-CTB elicited higher Vi antibody levels than the Vi alone (P less than 0.0001). Vi-CT and Vi-CTB were more immunogenic than Vis-CTB (P less than 0.01). CT or Vi-CT elicited higher levels of CT antibodies, as measured by enzyme-linked immunosorbent assay, than did CTB or Vi-CTB. In rhesus monkeys, the Vi conjugates elicited higher Vi antibody levels than the Vi alone (P less than 0.01). Vi-CTB elicited higher levels of Vi antibody after each injection than did Vis-CTB. Similar levels of CT antibodies, as measured by enzyme-linked immunosorbent assay, were elicited by all three conjugates. In contrast, Vi-CT elicited higher levels of neutralizing antibodies than Vi-CTB or Vis-CTB when either CT or the related heat-labile toxin of Escherichia coli was used as the antigen. These results indicate that the holotoxin and the native Vi provide the most immunogenic components for conjugates designed to induce both Vi and CT antibodies. JF - Infection and immunity AU - Szu, S C AU - Li, X R AU - Schneerson, R AU - Vickers, J H AU - Bryla, D AU - Robbins, J B AD - Laboratory of Developmental and Molecular Immunity, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 3823 EP - 3827 VL - 57 IS - 12 SN - 0019-9567, 0019-9567 KW - Adjuvants, Immunologic KW - 0 KW - Antibodies, Bacterial KW - Antitoxins KW - Polysaccharides, Bacterial KW - Typhoid-Paratyphoid Vaccines KW - Vi polysaccharide vaccine, typhoid KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Animals KW - Cholera Toxin -- immunology KW - Salmonella typhi -- immunology KW - Mice KW - Macaca mulatta KW - Molecular Weight KW - Antitoxins -- biosynthesis KW - Typhoid-Paratyphoid Vaccines -- immunology KW - Polysaccharides, Bacterial -- immunology KW - Antibodies, Bacterial -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79283286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Comparative+immunogenicities+of+Vi+polysaccharide-protein+conjugates+composed+of+cholera+toxin+or+its+B+subunit+as+a+carrier+bound+to+high-+or+lower-molecular-weight+Vi.&rft.au=Szu%2C+S+C%3BLi%2C+X+R%3BSchneerson%2C+R%3BVickers%2C+J+H%3BBryla%2C+D%3BRobbins%2C+J+B&rft.aulast=Szu&rft.aufirst=S&rft.date=1989-12-01&rft.volume=57&rft.issue=12&rft.spage=3823&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 1986 Aug;154(2):342-5 [2425009] Adv Enzymol Relat Areas Mol Biol. 1986;58:99-140 [3012972] Carbohydr Res. 1986 Sep 1;152:7-20 [3768916] Infect Immun. 1986 Nov;54(2):448-55 [3095243] Rev Infect Dis. 1987 May-Jun;9(3):544-61 [2440089] N Engl J Med. 1987 Oct 29;317(18):1101-4 [3657877] J Exp Med. 1987 Nov 1;166(5):1510-24 [3681191] Lancet. 1987 Nov 21;2(8569):1165-9 [2890805] J Clin Microbiol. 1988 Apr;26(4):719-25 [3366868] Infect Immun. 1988 Sep;56(9):2292-8 [3410538] Am J Hyg. 1954 Jul;60(1):52-62 [13180501] J Bacteriol. 1969 Jul;99(1):13-7 [5802598] J Bacteriol. 1969 Jul;99(1):8-12 [5802620] Prog Immunobiol Stand. 1971;5:485-91 [4633975] J Biol Chem. 1973 Jun 10;248(11):3838-44 [4196584] Science. 1974 Jan 25;183(4122):334-6 [4587905] Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Dec;81(6):757-62 [4592974] Infect Immun. 1974 Feb;9(2):348-53 [4205947] Infect Immun. 1975 Dec;12(6):1290-4 [54336] Infect Immun. 1977 Mar;15(3):988-92 [67084] Infect Immun. 1977 Nov;18(2):338-41 [336542] J Clin Microbiol. 1978 May;7(5):479-85 [350897] Am J Hyg. 1957 Jan;65(1):81-93 [13402749] Arch Biochem Biophys. 1958 Dec;78(2):306-18 [13618012] Arch Biochem Biophys. 1959 May;82(1):70-7 [13650640] J Bacteriol. 1967 Nov;94(5):1411-6 [4964477] Biochem J. 1978 Sep 1;173(3):723-37 [708370] Infect Immun. 1979 Jun;24(3):760-9 [89088] Infect Immun. 1981 Sep;33(3):677-82 [7026442] Infect Immun. 1982 Oct;38(1):267-72 [6183210] Diagn Microbiol Infect Dis. 1983 Jun;1(2):129-38 [6201315] J Immunol. 1984 Jun;132(6):2736-41 [6233359] Scand J Immunol. 1984 Jun;19(6):541-50 [6204375] Infect Immun. 1984 Sep;45(3):582-91 [6332076] J Infect Dis. 1984 Sep;150(3):436-49 [6207249] J Immunol. 1986 Aug 15;137(4):1181-6 [3016088] N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Assessment of strategies to promote cost and management efficiencies in tribal and contract health service programs: final report AN - 59530748; 1990-0801209 AB - Prepared by Support Services, Inc. Alternative methods of providing health care; case studies. Mashantucket Pequot, Devils Lake Sioux, Taholah Service Unit, and Puget Sound Service Area. JF - Washington, DC 20201, December 1989. xv+103 pp. Y1 - 1989/12// PY - 1989 DA - December 1989 EP - xv+103 PB - Washington, DC 20201 KW - Indians -- Medical care KW - Medical service -- Costs KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59530748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-12-01&rft.volume=&rft.issue=&rft.spage=xv%2B103&rft.isbn=&rft.btitle=Assessment+of+strategies+to+promote+cost+and+management+efficiencies+in+tribal+and+contract+health+service+programs%3A+final+report&rft.title=Assessment+of+strategies+to+promote+cost+and+management+efficiencies+in+tribal+and+contract+health+service+programs%3A+final+report&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20201 pa N1 - Document feature - chart(s), index(es) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Survival of Vibrio vulnificus in Shellstock and Shucked Oysters (Crassostrea gigas and Crassostrea virginica) and Effects of Isolation Medium on Recovery AN - 19075644; 9004932 AB - When two species of shellstock oysters were artificially contaminated with Vibrio vulnificus, the bacterium survived when the oysters were stored at 10 C and below. Large numbers of endogenous V. vulnificus cells were found after 7 days at both 0.5 and 10 C in uninoculated control oysters (Crassostrea virginica). Oysters allowed to take up V. vulnificus from seawater retained the bacterium for 14 days at 2 C. The presence of V. vulnificus in the drip exuded from the shellstock presented a possibility of contamination of other shellstock in storage. V. vulnificus injected into shucked Pacific (Crassostrea gigas) and Eastern (C. virginica) oysters survived at 4 C for at least 6 days. An 18-hour most-probable-number enrichment step in alkaline peptone water gave higher recovery levels of V. vulnificus than did direct plating to selective agars. The survival of this pathogen in both shellstock and shucked oysters suggests a potential for human illness, even though the product in refrigerated. (Author 's abstract) JF - Applied and Environmental Microbiology AEMIDF Vol. 55, No. 12, p 3072-3079, December 1989. 7 fig, 2 tab, 27 ref. AU - Kaysner, CA AU - Tamplin, M L AU - Wekell, M M AU - Stott, R F AU - Colburn, K G AD - Food and Drug Administration Bothell, WA. Seafood Products Research Center Y1 - 1989/12// PY - 1989 DA - Dec 1989 KW - Water Resources Abstracts KW - Food processing industry KW - Oysters KW - Vibrio KW - Pathogenic bacteria KW - Contamination KW - Food poisoning KW - Mollusks KW - Survival KW - Food contamination KW - Refrigeration KW - Pathogens KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19075644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Survival+of+Vibrio+vulnificus+in+Shellstock+and+Shucked+Oysters+%28Crassostrea+gigas+and+Crassostrea+virginica%29+and+Effects+of+Isolation+Medium+on+Recovery&rft.au=Kaysner%2C+CA%3BTamplin%2C+M+L%3BWekell%2C+M+M%3BStott%2C+R+F%3BColburn%2C+K+G&rft.aulast=Kaysner&rft.aufirst=CA&rft.date=1989-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Structural and conformational analyses of 8-hydroxy-2'-deoxyguanosine. AN - 79588020; 2519731 AB - Oxidative DNA damage has been shown to involve formation of 8-hydroxy-2'-deoxyguanosine, which may serve as a mispairing lesion during cellular DNA replication. In order to assess the mutagenic potential of this DNA adduct, we examined the possible occurrence of several tautomeric forms and of different base conformations about the deoxyribose. Several spectroscopic and electronic absorption techniques were employed and showed structural changes occurring over a broad pH range. Two pKa's near pH 8 and 12 were observed by pH-solvent partitioning experiments, ultraviolet absorption spectral analyses, and 13C NMR spectroscopic methods. The presence of two pKa's suggested the formation of a dianion, with the second being formed in strong alkali. A comparison of ultraviolet absorption band features of 8-hydroxy-2'-deoxyguanosine with that of different C6,C8-diketo or enol derivatives supported a C8-keto assignment and also provided evidence that this DNA adduct contains a C6-keto group at physiological pH. 13C NMR data showed marked chemical shifts at C6 in solutions of pH 7.4-9.3, indicating the location of the first ionization. Increasing basicity produced further shifts at C5 and C8, indicating the C8 position for the second ionization. Multiple infrared bands were observed in the carbonyl region of the neutral compound, but only a single carbonyl band at 1692 cm-1 remained at pH 9.1, implying a keto group at C8. Determination of the chemical shifts and the nuclear Overhauser enhancements of the N1 and N7 resonances in the proton-decoupled 15N NMR spectrum indicated that both nitrogens were indeed protonated at neutral pH.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Culp, S J AU - Cho, B P AU - Kadlubar, F F AU - Evans, F E AD - HFT-100, National Center for Toxicological Research, Jefferson, Arkansas 72079. PY - 1989 SP - 416 EP - 422 VL - 2 IS - 6 SN - 0893-228X, 0893-228X KW - Solvents KW - 0 KW - 8-oxo-7-hydrodeoxyguanosine KW - 88847-89-6 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Spectrophotometry, Infrared KW - Oxidation-Reduction KW - Hydrogen-Ion Concentration KW - Spectrophotometry, Ultraviolet KW - Molecular Conformation KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Deoxyguanosine -- chemistry KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79588020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Structural+and+conformational+analyses+of+8-hydroxy-2%27-deoxyguanosine.&rft.au=Culp%2C+S+J%3BCho%2C+B+P%3BKadlubar%2C+F+F%3BEvans%2C+F+E&rft.aulast=Culp&rft.aufirst=S&rft.date=1989-11-01&rft.volume=2&rft.issue=6&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-24 N1 - Date created - 1992-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine. AN - 79586604; 2519725 AB - Since the N-oxidation of several carcinogenic arylamines has been shown to be catalyzed preferentially by cytochrome P-450IA2 in several species, homologous ethynyl-substituted aromatic hydrocarbons, 2-ethynylnaphthalene, 1-ethynylnaphthalene, and 2-ethynylfluorene, were synthesized and examined as potential mechanism-based inactivators of this monooxygenase. By use of 2-naphthylamine, whose N-oxidation was known to be selectively catalyzed by rat cytochrome P-450ISF-G (P-450IA2), and hepatic microsomes from isosafrole-treated rats, each of these ethynyl derivatives was found to be strongly inhibitory at concentrations of 1 and 10 microM. However, only inhibition by 2-ethynylnaphthalene was significantly enhanced by prior incubation with the microsomal system. The inactivation of 2-naphthylamine N-oxidation was found to be NADPH- and time-dependent and to follow pseudo-first-order kinetics, demonstrating that 2-ethynylnaphthalene is a potent mechanism-based inactivator of the enzymatic activity. The extrapolated kinactivation and KI were 0.23 min-1 and 8 microM, respectively. By use of 2-aminofluorene, whose N-oxidation was known to be catalyzed by both cytochromes P-450ISF-G and P-450 beta NF-B (P-450IA1), and the purified enzymes in a reconstituted system, both 2-ethynylnaphthalene and 1-ethynylnaphthalene were found to be strongly inhibitory. However, 2-ethynylnaphthalene was a more potent inhibitor of the purified P-450ISF-G than of P-450 beta NF-B; and it was also found to be a more potent inhibitor of P-450ISF-G than was 1-ethynylnaphthalene.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Hammons, G J AU - Alworth, W L AU - Hopkins, N E AU - Guengerich, F P AU - Kadlubar, F F AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. PY - 1989 SP - 367 EP - 374 VL - 2 IS - 6 SN - 0893-228X, 0893-228X KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - Fluorenes KW - Naphthalenes KW - 2-ethynylnaphthalene KW - 2949-26-0 KW - 2-aminofluorene KW - 3A69OS195N KW - NADP KW - 53-59-8 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 2-Naphthylamine KW - CKR7XL41N4 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Fluorenes -- metabolism KW - Kinetics KW - In Vitro Techniques KW - NADP -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Male KW - Magnetic Resonance Spectroscopy KW - Naphthalenes -- pharmacology KW - 2-Naphthylamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79586604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=2-ethynylnaphthalene+as+a+mechanism-based+inactivator+of+the+cytochrome+P-450+catalyzed+N-oxidation+of+2-naphthylamine.&rft.au=Hammons%2C+G+J%3BAlworth%2C+W+L%3BHopkins%2C+N+E%3BGuengerich%2C+F+P%3BKadlubar%2C+F+F&rft.aulast=Hammons&rft.aufirst=G&rft.date=1989-11-01&rft.volume=2&rft.issue=6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-24 N1 - Date created - 1992-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prenatal reserpine exposure alters cardiovascular parameters in rat offspring. AN - 79463392; 2620789 AB - Electrocardiograms (ECGs) and blood pressures (BPs) were recorded and evaluated in postnatal rats that had been exposed in utero to 0.375 or 0.75 mg reserpine/kg/day sc on Gestational Days (GD) 12-15. These doses caused reduced maternal weight gain during pregnancy and decreased pup body weight at birth, as well as reduced heart weight during the preweaning period. There were no changes in other maternal parameters or in litter size. During the postweaning period, pup body weight was reduced only at the highest dose at Postnatal Days (PND) 30 and 60. By PND 342, the weight reduction was no longer significant when compared to controls. Lead II ECGs were recorded in conscious animals on PND 30, 60, and 342; BPs were recorded in anesthetized animals on PND 346. Several ECG parameters were attenuated by prenatal reserpine exposure: R wave and S wave amplitudes and the QRS interval in males, and the PR interval in females. The BP recordings showed that low-dose males had significantly higher pulse pressures than did high-dose males, but neither group was significantly different from controls. Following an intraarterial norepinephrine challenge, resultant peak pulse pressure was greater in high-dose females than in controls. These results indicate that subtle, long-term, sex-specific alterations in cardiovascular parameters were produced by prenatal reserpine treatment at doses that altered body weight in young animals at PNDs 30 and 60, but this change was no longer apparent at PND 342. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Sullivan-Jones, P AU - Kimmel, C A AU - Kimmel, G L AD - Perinatal and Postnatal Evaluation Branch, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 652 EP - 661 VL - 13 IS - 4 SN - 0272-0590, 0272-0590 KW - Reserpine KW - 8B1QWR724A KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Heart Rate -- drug effects KW - Sex Factors KW - Electrocardiography KW - Body Weight -- drug effects KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Pregnancy KW - Organ Size -- drug effects KW - Hemodynamics -- drug effects KW - Reserpine -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79463392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Prenatal+reserpine+exposure+alters+cardiovascular+parameters+in+rat+offspring.&rft.au=Sullivan-Jones%2C+P%3BKimmel%2C+C+A%3BKimmel%2C+G+L&rft.aulast=Sullivan-Jones&rft.aufirst=P&rft.date=1989-11-01&rft.volume=13&rft.issue=4&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-19 N1 - Date created - 1990-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Study of the teratogenic potential of FD & C Red No. 40 when given by gavage to rats. AN - 79438498; 2613118 AB - Osborne-Mendel rats were intubated with FD & C Red No. 40 at dose levels of 0, 30, 75, 150, 300, 600, or 1000 mg/kg body weight/day on days 0-19 of gestation. No developmental toxicity was observed when the animals were killed on day 20 of gestation. No dose-related changes were seen in maternal daily observations, food consumption, body-weight gain or implantations, or in foetal viability, body weight, body length, sex distribution or external variations. Skeletal and soft-tissue development appeared similar in foetuses of all groups. The isolated increases that occurred in the number of male foetuses, number of females with two or more resorptions, number of litters with three or more sternebral variations and incidence of 14th rib bud are considered random occurrences and were not related to dosage. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Collins, T F AU - Black, T N AU - Welsh, J J AU - Brown, L H AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 707 EP - 713 VL - 27 IS - 11 SN - 0278-6915, 0278-6915 KW - Azo Compounds KW - 0 KW - Food Coloring Agents KW - Teratogens KW - Allura Red AC Dye KW - 25956-17-6 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Body Weight -- drug effects KW - Male KW - Female KW - Pregnancy KW - Azo Compounds -- administration & dosage KW - Food Coloring Agents -- toxicity KW - Food Coloring Agents -- administration & dosage KW - Azo Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79438498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Study+of+the+teratogenic+potential+of+FD+%26amp%3B+C+Red+No.+40+when+given+by+gavage+to+rats.&rft.au=Collins%2C+T+F%3BBlack%2C+T+N%3BWelsh%2C+J+J%3BBrown%2C+L+H&rft.aulast=Collins&rft.aufirst=T&rft.date=1989-11-01&rft.volume=27&rft.issue=11&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-27 N1 - Date created - 1990-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS therapy and the detection of adverse drug effects in dental practice. AN - 79369404; 2592694 JF - Journal of the American Dental Association (1939) AU - Arrowsmith, J B AD - AIDS Coordination Staff, US Food and Drug Administration, ACS, Bethesda, MD 20857. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 46S EP - 48S VL - Suppl SN - 0002-8177, 0002-8177 KW - Zidovudine KW - 4B9XT59T7S KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Dentistry KW - Index Medicus KW - AIDS/HIV KW - United States KW - United States Food and Drug Administration KW - Drug and Narcotic Control KW - Humans KW - Zidovudine -- adverse effects KW - HIV Infections -- drug therapy KW - Mouth Diseases -- chemically induced KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Trimethoprim, Sulfamethoxazole Drug Combination -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79369404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=AIDS+therapy+and+the+detection+of+adverse+drug+effects+in+dental+practice.&rft.au=Arrowsmith%2C+J+B&rft.aulast=Arrowsmith&rft.aufirst=J&rft.date=1989-11-01&rft.volume=Suppl&rft.issue=&rft.spage=46S&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-24 N1 - Date created - 1990-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enzyme-linked immunosorbent assay of aflatoxins B1, B2, and G1 in corn, cottonseed, peanuts, peanut butter, and poultry feed: collaborative study. AN - 79366264; 2512279 AB - A direct competitive enzyme-linked immunosorbent assay (ELISA) screening method for aflatoxins at 20 ng/g was studied by 12 collaborators. Test samples of peanut butter were extracted by blending with methanol-water-hexane (55 + 45 + 100) and heating the test extracts on a steam bath; test samples of the other commodities were extracted by blending with methanol-water (80 + 20). All test extracts were filtered and the filtrates were diluted with buffer to a final methanol concentration of less than 30%. Each diluted filtrate was applied to a cup containing a filter with immobilized polyclonal antibodies specific to aflatoxins B1, B2, and G1. Aflatoxin B1-peroxidase conjugate was added, the cup was washed with water, and a mixture of hydrogen peroxide and tetramethylbenzidine was added. The test sample was judged to contain greater than or equal to 20 ng aflatoxins/g when, after exactly 1 min, no color was observed on the filter; when a blue or gray color developed, the test sample was judged to contain less than 20 ng aflatoxins/g. All collaborators correctly identified naturally contaminated corn and raw peanut positive test samples. No false positives were found for controls containing less than 2 ng aflatoxins/g. The correct responses for positive test samples spiked at levels of 10, 20, and greater than or equal to 30 ng aflatoxins/g (the ratio of B1:B2:G1 was 10:1:3) were 52, 86, and 96%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal - Association of Official Analytical Chemists AU - Trucksess, M W AU - Stack, M E AU - Nesheim, S AU - Park, D L AU - Pohland, A E AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 957 EP - 962 VL - 72 IS - 6 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Indicators and Reagents KW - aflatoxin G1 KW - 1DB78J7PUD KW - aflatoxin B2 KW - 7SKR7S646P KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Arachis -- analysis KW - Animal Feed -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Zea mays -- analysis KW - Gossypium -- analysis KW - Aflatoxins -- analysis KW - Food Microbiology KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79366264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Enzyme-linked+immunosorbent+assay+of+aflatoxins+B1%2C+B2%2C+and+G1+in+corn%2C+cottonseed%2C+peanuts%2C+peanut+butter%2C+and+poultry+feed%3A+collaborative+study.&rft.au=Trucksess%2C+M+W%3BStack%2C+M+E%3BNesheim%2C+S%3BPark%2C+D+L%3BPohland%2C+A+E&rft.aulast=Trucksess&rft.aufirst=M&rft.date=1989-11-01&rft.volume=72&rft.issue=6&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethyl carbamate levels in selected fermented foods and beverages. AN - 79366224; 2592308 AB - Ethyl carbamate (EC), also known as urethane, is an animal carcinogen and a by-product of fermentation. Because EC has been found in distilled spirits and wines, a variety of fermented foods and beverages were analyzed to assess its occurrence in other products. Previously described methods using a gas chromatograph-thermal energy analyzer with a nitrogen converter were modified for each matrix and gave recoveries of greater than 80%, with a limit of detection in the 1-2 micrograms/kg (ppb) range. A total of 152 test samples were analyzed; EC levels ranged from none found to 3 ppb in 15 cheeses, 6 teas, 12 yogurts, and 8 ciders; from none found to 13 ppb in 30 breads and 69 malt beverages; and from none found to 84 ppb in 12 soy sauces. Gas chromatography/mass spectrometry/mass spectrometry was used to confirm EC identity and to quantitate EC in selected food extracts. JF - Journal - Association of Official Analytical Chemists AU - Canas, B J AU - Havery, D C AU - Robinson, L R AU - Sullivan, M P AU - Joe, F L AU - Diachenko, G W AD - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204. PY - 1989 SP - 873 EP - 876 VL - 72 IS - 6 SN - 0004-5756, 0004-5756 KW - Indicators and Reagents KW - 0 KW - Urethane KW - 3IN71E75Z5 KW - Index Medicus KW - Fermentation KW - Gas Chromatography-Mass Spectrometry KW - Electrochemistry KW - Bread -- analysis KW - Alcoholic Beverages -- analysis KW - Beverages -- analysis KW - Food Analysis KW - Urethane -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79366224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Ethyl+carbamate+levels+in+selected+fermented+foods+and+beverages.&rft.au=Canas%2C+B+J%3BHavery%2C+D+C%3BRobinson%2C+L+R%3BSullivan%2C+M+P%3BJoe%2C+F+L%3BDiachenko%2C+G+W&rft.aulast=Canas&rft.aufirst=B&rft.date=1989-11-01&rft.volume=72&rft.issue=6&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Turbidimetric microbiological assay results calculated by a BASIC computer program. AN - 79365063; 2687226 AB - A BASIC computer program was used to calculate the results of microbiological vitamin assays. The program, which incorporates the official AOAC guidelines for microbiological methods, reduces the uncertainty inherent in manual curve plotting and interpolation and minimizes the human error of repetitive calculations. Because the BASIC programming language is well suited for use on self-contained personal computers, it can be easily adapted by small laboratories. JF - Journal - Association of Official Analytical Chemists AU - Anderson, E M AD - Food and Drug Administration, Division of Nutrition, Washington, DC 20204. PY - 1989 SP - 950 EP - 952 VL - 72 IS - 6 SN - 0004-5756, 0004-5756 KW - Index Medicus KW - Food Microbiology KW - Software KW - Nephelometry and Turbidimetry -- instrumentation KW - Microbiological Techniques -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79365063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Turbidimetric+microbiological+assay+results+calculated+by+a+BASIC+computer+program.&rft.au=Anderson%2C+E+M&rft.aulast=Anderson&rft.aufirst=E&rft.date=1989-11-01&rft.volume=72&rft.issue=6&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of gelatin on recovery of hair fragments in filth analysis. AN - 79364980; 2592307 AB - Prior literature has recommended the use of gelatin capsules or gelatin film for transferring spike elements to samples being examined for recovery studies. It was believed that gelatin had no effect on the recovery of filth spike elements. However, this study shows that hair recovery is lower when gelatin is present in direct trap-off procedures. Two types of gelatin capsules, gelatin film, and strips of filter paper were used to transfer spike filth elements. A comparison study employing an acid digestion and wet sieving procedure was also performed and showed that gelatin had little or no effect on the recovery of hairs using this type of procedure. An additional test was performed using gelatin added to water containing the same type of spiked filth elements. No hair fragments were recovered but all insect fragments were recovered. All recovery studies were performed using only water in the liquid phase of the trap flask extractions, with mineral oil or heptane as the flotation medium. No food product was used. JF - Journal - Association of Official Analytical Chemists AU - Beavin, B B AD - Food and Drug Administration, Baltimore, MD 21201. PY - 1989 SP - 1014 EP - 1015 VL - 72 IS - 6 SN - 0004-5756, 0004-5756 KW - Gelatin KW - 9000-70-8 KW - Index Medicus KW - Animals KW - Insects -- analysis KW - Hair -- analysis KW - Food Contamination -- analysis KW - Gelatin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79364980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Effect+of+gelatin+on+recovery+of+hair+fragments+in+filth+analysis.&rft.au=Beavin%2C+B+B&rft.aulast=Beavin&rft.aufirst=B&rft.date=1989-11-01&rft.volume=72&rft.issue=6&rft.spage=1014&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The evolution of federal x-ray protection programs. AN - 79354931; 2685945 JF - Radiographics : a review publication of the Radiological Society of North America, Inc AU - Barnett, M AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1277 EP - 1282 VL - 9 IS - 6 SN - 0271-5333, 0271-5333 KW - Index Medicus KW - History of medicine KW - United States KW - History, 20th Century KW - Humans KW - Radiation Protection -- legislation & jurisprudence KW - Radiation Protection -- history KW - Radiation Protection -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79354931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiographics+%3A+a+review+publication+of+the+Radiological+Society+of+North+America%2C+Inc&rft.atitle=The+evolution+of+federal+x-ray+protection+programs.&rft.au=Barnett%2C+M&rft.aulast=Barnett&rft.aufirst=M&rft.date=1989-11-01&rft.volume=9&rft.issue=6&rft.spage=1277&rft.isbn=&rft.btitle=&rft.title=Radiographics+%3A+a+review+publication+of+the+Radiological+Society+of+North+America%2C+Inc&rft.issn=02715333&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-09 N1 - Date created - 1990-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occurrence and Characteristics of Agglutination of Vibrio cholerae by Serum from the Eastern Oyster, Crassostrea virginica AN - 19087936; 9004033 AB - Cell-free hemolymph (serum) of the eastern oyster, Crassostrea virginica, agglutinated Vibrio cholerae an aquatic bacterium pathogenic to humans. Seventy-nine other strains of bacteria, including 14 genera and 26 species, were not agglutinated. The A , B, and C factors of O1 antigen were not involved in agglutination. Bacterial agglutinating (BA) activity was demonstrated for oysters inhabiting different environments of the U.S. Atlantic and Gulf coasts. Oyster serum BA titers showed high individual variation. The serum components involved in BA activity were inhibited by 80 C heat, pronase, EDTA, mucin, and fetuin treatments. N-Acetylneuraminic acid (10 mg/ml) weakly inhibited BA activity. Ligands of V. cholerae were sensitive to neuraminidase and resistant to 80 C and pronase. High salinities (24 and 30%) enhanced BA activity. Cross-adsorption tests with V. cholerae and human O+ erythrocytes indicated that BA and hemagglutinating activities may involve different serum components. These results imply that the ecology of V. cholerae in C. virginica is influenced by agglutinating activity of oyster serum. (Author 's abstract) JF - Applied and Environmental Microbiology AEMIDF Vol. 55, No. 11, p 2882-2887, November 1989. 6 tab, 35 ref. AU - Tamplin, M L AU - Fisher, W S AD - Food and Drug Administration Dauphin Island, AL. Fishery Research Branch Y1 - 1989/11// PY - 1989 DA - Nov 1989 KW - Water Resources Abstracts KW - Human pathogens KW - Pathogenic bacteria KW - Oysters KW - Vibrio KW - Path of pollutants KW - Aquatic bacteria KW - Salinity KW - Adsorption KW - Blood KW - Estuaries KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19087936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Occurrence+and+Characteristics+of+Agglutination+of+Vibrio+cholerae+by+Serum+from+the+Eastern+Oyster%2C+Crassostrea+virginica&rft.au=Tamplin%2C+M+L%3BFisher%2C+W+S&rft.aulast=Tamplin&rft.aufirst=M&rft.date=1989-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - The estimation of total serum lipids by a completely enzymatic 'summation' method. AN - 79433374; 2611996 AB - Expressing serum organic toxicant concentrations per weight of total lipid rather than by volume of serum is often advantageous, but it requires a reliable and convenient method for determining the total serum lipids. We compared a completely enzymatic 'summation' method for estimating serum total lipids with a traditional gravimetric analysis. Serum total cholesterol (TC), nonesterified cholesterol (FC), triglycerides (TG), and phospholipids (PL) were assayed by automated, enzymatic methods and total lipids (TL) were calculated from the expression TL = 1.677 * (TC-FC) + FC + TG + PL. Examining three reference serum pools by both summation and gravimetric methods yielded results that agreed within 1-3%. The evaluation of thirty serum samples resulted in similar mean total lipid values (697 mg/dl gravimetric; 675 mg/dl summation) with excellent correlation between the two methods (r2 = 0.978). We conclude that the enzymatic summation procedure is a useful method for routinely estimating serum total lipid content. JF - Clinica chimica acta; international journal of clinical chemistry AU - Akins, J R AU - Waldrep, K AU - Bernert, J T AD - Division of Environmental Health Laboratory Sciences, US Department of Health and Human Services, Atlanta, GA 30333. Y1 - 1989/10/16/ PY - 1989 DA - 1989 Oct 16 SP - 219 EP - 226 VL - 184 IS - 3 SN - 0009-8981, 0009-8981 KW - Cholesterol Esters KW - 0 KW - Lipids KW - Phospholipids KW - Triglycerides KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Triglycerides -- blood KW - Phospholipids -- blood KW - Cholesterol -- blood KW - Reference Values KW - Methods KW - Humans KW - Cholesterol Esters -- blood KW - Adult KW - Lipids -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79433374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinica+chimica+acta%3B+international+journal+of+clinical+chemistry&rft.atitle=The+estimation+of+total+serum+lipids+by+a+completely+enzymatic+%27summation%27+method.&rft.au=Akins%2C+J+R%3BWaldrep%2C+K%3BBernert%2C+J+T&rft.aulast=Akins&rft.aufirst=J&rft.date=1989-10-16&rft.volume=184&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Clinica+chimica+acta%3B+international+journal+of+clinical+chemistry&rft.issn=00098981&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-06 N1 - Date created - 1990-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of a hearing conservation program data base: factors other than workplace noise. AN - 85144654; pmid-2792579 AB - The hearing conservation records of a large, multiple-facility printing company were obtained. The records were analyzed for factors associated with Standard Threshold Shift. These factors included hearing levels, employee age and sex, occupational and nonoccupational noise exposure histories, and medical history. The analysis revealed that statistically significant factors associated with Standard Threshold Shift were from medical and nonoccupational noise exposure histories, and not occupational noise exposure. JF - Ear and Hearing AU - Franks, John Richard AU - Davis, R R AU - Kreig, E F AD - Department of Speech and Hearing Science, College of Social and Behavioral Sciences, Colleges of the Arts and Sciences, Ohio State University; Bioacoustics and Occupational Vibration Section, Physical Agents Effects Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. PY - 1989 SP - 273 EP - 280 VL - 10 IS - 5 SN - 0196-0202, 0196-0202 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85144654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+Hearing&rft.atitle=Analysis+of+a+hearing+conservation+program+data+base%3A+factors+other+than+workplace+noise.&rft.au=Franks%2C+John+Richard%3BDavis%2C+R+R%3BKreig%2C+E+F&rft.aulast=Franks&rft.aufirst=John&rft.date=1989-10-01&rft.volume=10&rft.issue=5&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Ear+and+Hearing&rft.issn=01960202&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Induction of ornithine decarboxylase in the stomach mucosa of swine with NaCl or 12-O-tetradecanoylphorbol-13-acetate. AN - 79443341; 2558942 AB - The effect of sodium chloride and 12-O-tetradecanoylphorbol-13-acetate on ornithine decarboxylase (ODC) activity in gastric mucosa of miniature swine was investigated as a model for gastric inflammation. The level of the enzyme was lower in the pylorus than in the fundic or cardiac regions of the stomach in untreated animals. Treatment with sodium chloride at 1 g/kg produced large increases in all three regions, with the greatest relative increase in the pylorus. Treatment with sodium chloride at 0.25 g/kg or the phorbol ester at 2.0 mg/pig produced significant but less dramatic increases. ODC activity in control and treated mucosal extracts was inhibited by the specific ODC inhibitor difluoromethylornithine. Most of the enzyme activity was associated with superficial and exfoliated cells that could be scraped from the mucosal surface. No increase in the inflammatory mediator leukotriene B4 was observed in the mucosal extracts. Ornithine decarboxylase appears to be a useful enzymatic marker for the regenerative events that occur after tissue damage and may correlate with the putative tumor-promoting function of sodium chloride in gastric tissues. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Raybourne, R B AU - Bier, J W AU - Gaines, D W AU - Hines, F A AU - Friedman, L AD - Division of Microbiology, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 585 EP - 592 VL - 13 IS - 3 SN - 0272-0590, 0272-0590 KW - Leukotriene B4 KW - 1HGW4DR56D KW - Sodium Chloride KW - 451W47IQ8X KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Swine KW - Animals KW - Sodium Chloride -- toxicity KW - Leukotriene B4 -- metabolism KW - Enzyme Induction -- drug effects KW - Male KW - Tetradecanoylphorbol Acetate -- toxicity KW - Gastric Mucosa -- enzymology KW - Gastric Mucosa -- drug effects KW - Ornithine Decarboxylase -- biosynthesis KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79443341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Induction+of+ornithine+decarboxylase+in+the+stomach+mucosa+of+swine+with+NaCl+or+12-O-tetradecanoylphorbol-13-acetate.&rft.au=Raybourne%2C+R+B%3BBier%2C+J+W%3BGaines%2C+D+W%3BHines%2C+F+A%3BFriedman%2C+L&rft.aulast=Raybourne&rft.aufirst=R&rft.date=1989-10-01&rft.volume=13&rft.issue=3&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-06 N1 - Date created - 1990-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Salmonella typhi vaccine strain in vitro; low infectivity in human cell line U937. AN - 79442628; 2613709 AB - Salmonella typhi strain Ty21a has been used for live oral vaccine. The infectivity of Ty21a, in comparison with S. typhi Ty2, was evaluated using the human monocyte-macrophage cell line U937. Assays were performed by quantitative microscopy and viable count technique. Ty2 infected approximately 100% of the cells, multiplied extensively within these cells and caused cell death. The same dose of Ty21a infected only about 15% of the cells, resulting in a low number of intracellular bacilli and cell survival. The use of gentamicin in the test confirmed intracellular multiplication of Ty2 but not Ty21a. The system described may be suitable as a test system for characterization of the degree of virulence of Ty21a and other live, oral typhoid vaccines. JF - Journal of biological standardization AU - Dragunsky, E M AU - Wooden, C R AU - Vargo, S A AU - Levenbook, I S AD - Division of Product Quality Control, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 353 EP - 360 VL - 17 IS - 4 SN - 0092-1157, 0092-1157 KW - Bacterial Vaccines KW - 0 KW - Culture Media KW - Gentamicins KW - Vaccines, Attenuated KW - Index Medicus KW - Humans KW - Vaccines, Attenuated -- toxicity KW - Colony Count, Microbial KW - Phagocytosis -- immunology KW - Cell Line KW - Gentamicins -- pharmacology KW - Salmonella typhi -- pathogenicity KW - Bacterial Vaccines -- toxicity KW - Salmonella typhi -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79442628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biological+standardization&rft.atitle=Salmonella+typhi+vaccine+strain+in+vitro%3B+low+infectivity+in+human+cell+line+U937.&rft.au=Dragunsky%2C+E+M%3BWooden%2C+C+R%3BVargo%2C+S+A%3BLevenbook%2C+I+S&rft.aulast=Dragunsky&rft.aufirst=E&rft.date=1989-10-01&rft.volume=17&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+biological+standardization&rft.issn=00921157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-06 N1 - Date created - 1990-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. AN - 79306443; 2813353 AB - Aromatic amines are well known as occupational carcinogens and are found in cooked foods, tobacco smoke, synthetic fuels, and agricultural chemicals. For the primary arylamines, metabolic N-oxidation by hepatic cytochromes P-450 is generally regarded as an initial activation step leading to carcinogenesis. The metabolic activation of 4-aminobiphenyl, 2-naphthylamine, and several heterocyclic amines has been shown recently to be catalyzed by rat cytochrome P-450ISF-G and by its human ortholog, cytochrome P-450PA. We now report that human hepatic microsomal caffeine 3-demethylation, the initial major step in caffeine biotransformation in humans, is selectively catalyzed by cytochrome P-450PA. Caffeine 3-demethylation was highly correlated with 4-aminobiphenyl N-oxidation (r = 0.99; P less than 0.0005) in hepatic microsomal preparations obtained from 22 human organ donors, and both activities were similarly decreased by the selective inhibitor, 7,8-benzoflavone. The rates of microsomal caffeine 3-demethylation, 4-aminobiphenyl N-oxidation, and phenacetin O-deethylation were also significantly correlated with each other and with the levels of immunoreactive human cytochrome P-450PA. Moreover, a rabbit polyclonal antibody raised to human cytochrome P-450PA was shown to inhibit strongly all three of these activities and to inhibit the N-oxidation of the carcinogen 2-naphthylamine and the heterocyclic amines, 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole and 2-amino-3-methylimidazo[4,5-f]-quinoline. Human liver cytochrome P-450PA was also shown to catalyze caffeine 3-demethylation, 4-aminobiphenyl N-oxidation, and phenacetin O-deethylation. Thus, estimation of caffeine 3-demethylation activity in humans may be useful in the characterization of arylamine N-oxidation phenotypes and in the assessment of whether or not the hepatic levels of cytochrome P-450PA, as affected by environmental or genetic factors, contribute to interindividual differences in susceptibility to arylamine-induced cancers. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Butler, M A AU - Iwasaki, M AU - Guengerich, F P AU - Kadlubar, F F AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 7696 EP - 7700 VL - 86 IS - 20 SN - 0027-8424, 0027-8424 KW - Amines KW - 0 KW - Carcinogens KW - Caffeine KW - 3G6A5W338E KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxidoreductases KW - EC 1.- KW - Cytochrome P-450 CYP1A2 KW - EC 1.14.14.1 KW - Index Medicus KW - Oxidation-Reduction KW - Kinetics KW - Humans KW - Amines -- metabolism KW - Substrate Specificity KW - Oxidoreductases -- isolation & purification KW - Caffeine -- metabolism KW - Carcinogens -- metabolism KW - Oxidoreductases -- metabolism KW - Microsomes, Liver -- enzymology KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79306443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Human+cytochrome+P-450PA+%28P-450IA2%29%2C+the+phenacetin+O-deethylase%2C+is+primarily+responsible+for+the+hepatic+3-demethylation+of+caffeine+and+N-oxidation+of+carcinogenic+arylamines.&rft.au=Butler%2C+M+A%3BIwasaki%2C+M%3BGuengerich%2C+F+P%3BKadlubar%2C+F+F&rft.aulast=Butler&rft.aufirst=M&rft.date=1989-10-01&rft.volume=86&rft.issue=20&rft.spage=7696&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-01 N1 - Date created - 1989-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Pharmacol Ther. 1983 May;33(5):591-602 [6687705] Clin Pharmacol Ther. 1982 Aug;32(2):261-9 [6807598] Carcinogenesis. 1984 Dec;5(12):1717-23 [6499123] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7348-52 [6594694] Mutat Res. 1985 Jun-Jul;150(1-2):33-41 [3889618] Cancer Res. 1985 Aug;45(8):3578-85 [4016738] J Biol Chem. 1985 Jul 25;260(15):9057-67 [4019462] Carcinogenesis. 1985 Dec;6(12):1721-4 [4064248] Mol Pharmacol. 1986 Apr;29(4):405-10 [3517618] DNA. 1987 Feb;6(1):1-11 [3829886] Drug Metab Dispos. 1987 Mar-Apr;15(2):237-49 [2882985] Jpn J Cancer Res. 1987 Apr;78(4):297-311 [3108208] Biochem Pharmacol. 1987 Apr 15;36(8):1251-60 [3593412] Clin Pharmacol Ther. 1987 Aug;42(2):157-65 [3608349] Occup Med. 1987 Jan-Mar;2(1):85-107 [3306981] J Exp Pathol. 1987 Winter;3(1):1-17 [3681487] Carcinogenesis. 1988 Jan;9(1):105-9 [3121205] Biochem Pharmacol. 1988 Feb 1;37(3):459-65 [3337745] Cancer Res. 1988 Aug 15;48(16):4513-9 [3396004] Br J Clin Pharmacol. 1988 Oct;26(4):363-72 [3190986] Cancer Res. 1989 Jun 15;49(12):3218-28 [2655891] J Biol Chem. 1964 Jul;239:2370-8 [14209971] Cancer Res. 1989 Jan 1;49(1):25-31 [2908851] Jpn J Cancer Res. 1988 Nov;79(11):1159-67 [3147272] J Med Chem. 1969 Mar;12(2):207-11 [5783590] Science. 1972 Mar 17;175(4027):1248-50 [5061244] Clin Pharmacol Ther. 1974 Jan;15(1):9-17 [4808745] J Biol Chem. 1976 Sep 10;251(17):5337-44 [821951] Clin Pharmacol Ther. 1976 Dec;20(6):633-42 [991534] Clin Pharmacol Ther. 1977 Feb;21(2):166-76 [837635] Clin Pharmacol Ther. 1977 Nov;22(5 Pt 2):791-8 [410581] Life Sci. 1977 Oct 1;21(7):967-74 [927023] Clin Pharmacol Ther. 1978 Jul;24(1):40-5 [657717] Annu Rev Pharmacol Toxicol. 1979;19:129-57 [378100] Cancer Res. 1981 Jan;41(1):67-72 [7448777] Arch Biochem Biophys. 1980 Dec;205(2):365-79 [6781411] J Biol Chem. 1981 Jul 10;256(13):6829-36 [6263924] Drug Metab Dispos. 1981 May-Jun;9(3):292-6 [6113943] Toxicol Lett. 1980 Nov;7(1):1-7 [7292511] Methods Enzymol. 1981;74 Pt C:262-72 [7321884] Eur J Clin Pharmacol. 1981;21(1):53-9 [6800827] Clin Pharmacol Ther. 1982 Jul;32(1):98-106 [7083737] Br J Clin Pharmacol. 1983 Aug;16(2):157-66 [6615690] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of teratogenic and carcinogenic risks. AN - 79306260; 2813866 AB - Risk assessment for teratogens has received much less attention than carcinogens. This may be due in part to the lack of biologically based dose-response models for teratogens. Also, there appears to be a perception that cancer risks far exceed teratogenic risks for most chemicals. This perception may be due in large part to the stringent practice of using conservative procedures to restrict cancer risk estimates to one in 100,000 or lower whereas procedures used to restrict teratogens may result in much higher risks. The purpose of this paper is to compare estimates of teratogenic and carcinogenic risks for chemicals when both effects occur in the same animal species. Similar procedures are employed here to obtain teratogenic and carcinogenic risk estimates for nine chemicals. When a similar standard of risk is applied to both effects, the relative potency of teratogens to carcinogens varied from an order of magnitude lower to an order of magnitude higher for these nine chemicals. JF - Regulatory toxicology and pharmacology : RTP AU - Gaylor, D W AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 138 EP - 143 VL - 10 IS - 2 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Teratogens KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Carcinogens -- toxicity KW - Teratogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79306260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Comparison+of+teratogenic+and+carcinogenic+risks.&rft.au=Gaylor%2C+D+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=1989-10-01&rft.volume=10&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-18 N1 - Date created - 1989-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Workshop on risk assessment in reproductive and developmental toxicology: addressing the assumptions and identifying the research needs. AN - 79303948; 2682812 AB - The risk assessment process is an imprecise procedure aimed at determining a toxicant exposure level with an acceptable risk to the human population. The lack of precision is due to the uncertainties in the assumptions that must be made due to the lack of specific scientific information or knowledge of how to use certain types of data. Unfortunately, every necessary piece of information cannot be obtained for every chemical requiring a risk assessment. In order to better identify and understand some of the assumptions that are made in the risk assessment of reproductive and developmental toxicants, a workshop was organized to specifically define the assumptions underlying the risk assessments for seven specific toxicants (dibromochloropropane, dioxin, glycol ethers, heptachlor, lead, tetrahydrocannabinol, and vitamin A) and to determine the potential research which would reduce the uncertainty associated with making those assumptions. The major assumptions discussed centered around the topics of heterogeneous populations, thresholds, safety factors, exposure assessment, quantitative structure-activity relationships, and mechanisms. This report is the summary of the workshop discussions. JF - Regulatory toxicology and pharmacology : RTP AU - Sheehan, D M AU - Young, J F AU - Slikker, W AU - Gaylor, D W AU - Mattison, D R AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 110 EP - 122 VL - 10 IS - 2 SN - 0273-2300, 0273-2300 KW - Teratogens KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Humans KW - Research KW - Structure-Activity Relationship KW - Reproduction -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79303948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Workshop+on+risk+assessment+in+reproductive+and+developmental+toxicology%3A+addressing+the+assumptions+and+identifying+the+research+needs.&rft.au=Sheehan%2C+D+M%3BYoung%2C+J+F%3BSlikker%2C+W%3BGaylor%2C+D+W%3BMattison%2C+D+R&rft.aulast=Sheehan&rft.aufirst=D&rft.date=1989-10-01&rft.volume=10&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-18 N1 - Date created - 1989-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sulfa residues in pork: an update. AN - 79295005; 2681113 AB - Sulfamethazine (SMZ) is an antibacterial drug used in approximately 75% of all hogs marketed in the U.S. The tolerance for residues of SMZ in uncooked tissues is .1 ppm, and the withdrawal time is 15 d. The rate of illegal residues in swine from the use of SMZ has continued to fluctuate between 4% and 5% from 1980 through 1987. This was not acceptable. The Center for Veterinary Medicine (CVM) also has received from the National Center for Toxicological Research a report showing that SMZ produces a dose-related increase in follicular cell adenomas of the thyroid gland in rats and mice. The FDA has discovered three major causes of SMZ residues by investigating violators. The number one cause was a lack of sequencing, flushing, and cleaning of mixer equipment. Failure to follow withdrawal times was another major cause, and the third major reason was the use of a soluble powder solution. At least 16% of SMZ residue violations have resulted in no follow-up due to lack of animal identification. The FDA district offices are conducting on-farm investigations of swine producers who have caused SMZ violations. Repeat violators and those that produce higher residue levels will receive a higher priority. The FDA currently is attempting to obtain more state support, particularly for investigation of first-time violators. The CVM is serious about resolving the SMZ residue problem. JF - Journal of animal science AU - Augsburg, J K AD - Food and Drug Administration, Rockville, MD 20857. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 2817 EP - 2821 VL - 67 IS - 10 SN - 0021-8812, 0021-8812 KW - Sulfamethazine KW - 48U51W007F KW - Index Medicus KW - United States KW - Swine KW - Animals KW - United States Food and Drug Administration KW - Sulfamethazine -- analysis KW - Food Contamination -- prevention & control KW - Drug Residues -- analysis KW - Meat -- analysis KW - Food Inspection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79295005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+animal+science&rft.atitle=Sulfa+residues+in+pork%3A+an+update.&rft.au=Augsburg%2C+J+K&rft.aulast=Augsburg&rft.aufirst=J&rft.date=1989-10-01&rft.volume=67&rft.issue=10&rft.spage=2817&rft.isbn=&rft.btitle=&rft.title=Journal+of+animal+science&rft.issn=00218812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-12 N1 - Date created - 1989-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The future of automated record linkage for postmarketing surveillance: a response to Shapiro. AN - 79219822; 2791441 JF - Clinical pharmacology and therapeutics AU - Faich, G A AU - Stadel, B V AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 387 EP - 389 VL - 46 IS - 4 SN - 0009-9236, 0009-9236 KW - Abridged Index Medicus KW - Index Medicus KW - Medical Records KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Medical Record Linkage -- methods KW - Product Surveillance, Postmarketing -- trends KW - Automatic Data Processing -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79219822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=The+future+of+automated+record+linkage+for+postmarketing+surveillance%3A+a+response+to+Shapiro.&rft.au=Faich%2C+G+A%3BStadel%2C+B+V&rft.aulast=Faich&rft.aufirst=G&rft.date=1989-10-01&rft.volume=46&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-22 N1 - Date created - 1989-11-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Clin Pharmacol Ther. 1989 Oct;46(4):371-86 [2535647] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - American Indians, Stress, and Alcohol AN - 61223093; 91X5540 AB - The causal relationship of stress to Indian drinking & alcohol's role as a stressor are explored based on a review of the literature on American Indian & Alaska Native drinking. It is concluded that some drinking behavior is a response to psychosocial stressors & that rapid ingestion or large quantity alcohol consumption may precipitate psychogenic stress response, thereby exacerbating stress in the individual as well as increasing opportunities for injury & illness. Health care workers need a better understanding of the human stress response, especially its cultural components, to help clients develop personal coping skills. Directions for further prevention, intervention, treatment, & rehabilitation efforts are considered. 1 Table, 68 References. Adapted from the source document. JF - American Indian and Alaska Native Mental Health Research AU - Mail, Patricia D AD - Public Health Service Dept Health & Human Services, Rockville MD 20857 Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 7 EP - 26 VL - 3 IS - 2 SN - 0893-5394, 0893-5394 KW - drinking-stress relationship, American Indians/Alaska Natives KW - Psychological Stress KW - Eskimos KW - Drinking Behavior KW - Traditional Societies KW - Alaska KW - American Indians KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61223093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Indian+and+Alaska+Native+Mental+Health+Research&rft.atitle=American+Indians%2C+Stress%2C+and+Alcohol&rft.au=Mail%2C+Patricia+D&rft.aulast=Mail&rft.aufirst=Patricia&rft.date=1989-10-01&rft.volume=3&rft.issue=2&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=American+Indian+and+Alaska+Native+Mental+Health+Research&rft.issn=08935394&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AIAREB N1 - SubjectsTermNotLitGenreText - American Indians; Traditional Societies; Alaska; Eskimos; Drinking Behavior; Psychological Stress ER - TY - JOUR T1 - Multiresidue procedures for the determination of chlorinated dibenzodioxins and dibenzofurans in a variety of foods using capillary gas chromatography-electron-capture detection. AN - 79390653; 2600146 AB - Multiresidue digestion-extraction procedures for the determination of chlorinated dioxins and furans in a wide variety of products are presented. Procedure selection is dependent upon the residue(s) of interest, and on the fat content of the product. Additional cleanup is accomplished using column chromatography and a Florisil trap. The separation of residues is achieved by fraction collection off of two high-performance liquid chromatographic systems. Capillary gas chromatography employing electron-capture detection is used for quantitation. The extracts are suitable for gas chromatography mass spectrometry or gas chromatography with Hall electrolytic conductivity detection. Results of analysis, recovery data, and interlaboratory comparisons are presented. Spike recoveries will typically average 90% +/- 10%. JF - Journal of chromatography AU - Jasinski, J S AD - U.S. Department of Health and Human Services, Food and Drug Administration, Detroit, MI 48207. Y1 - 1989/09/15/ PY - 1989 DA - 1989 Sep 15 SP - 349 EP - 367 VL - 478 IS - 2 KW - Benzofurans KW - 0 KW - Dioxins KW - Chlorine KW - 4R7X1O2820 KW - Methylene Chloride KW - 588X2YUY0A KW - dibenzofuran KW - 8U54U639VI KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Isomerism KW - Chromatography, High Pressure Liquid KW - Food Analysis -- methods KW - Dioxins -- metabolism KW - Dioxins -- analysis KW - Benzofurans -- analysis KW - Chlorine -- metabolism KW - Chromatography, Gas -- methods KW - Benzofurans -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79390653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography&rft.atitle=Multiresidue+procedures+for+the+determination+of+chlorinated+dibenzodioxins+and+dibenzofurans+in+a+variety+of+foods+using+capillary+gas+chromatography-electron-capture+detection.&rft.au=Jasinski%2C+J+S&rft.aulast=Jasinski&rft.aufirst=J&rft.date=1989-09-15&rft.volume=478&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-29 N1 - Date created - 1990-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic toxicity after acebutolol therapy. AN - 79197371; 2774374 JF - Annals of internal medicine AU - Tanner, L A AU - Bosco, L A AU - Zimmerman, H J AD - Division of Epidemiology and Surveillance, Center for Drug Evaluation and Research, Rockville, Maryland. Y1 - 1989/09/15/ PY - 1989 DA - 1989 Sep 15 SP - 533 EP - 534 VL - 111 IS - 6 SN - 0003-4819, 0003-4819 KW - Acebutolol KW - 67P356D8GH KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Adult KW - Middle Aged KW - Liver Function Tests KW - Recurrence KW - Male KW - Liver Diseases -- diagnosis KW - Female KW - Chemical and Drug Induced Liver Injury KW - Acebutolol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79197371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Hepatic+toxicity+after+acebutolol+therapy.&rft.au=Tanner%2C+L+A%3BBosco%2C+L+A%3BZimmerman%2C+H+J&rft.aulast=Tanner&rft.aufirst=L&rft.date=1989-09-15&rft.volume=111&rft.issue=6&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-29 N1 - Date created - 1989-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of nitro-substitution of environmental polycyclic aromatic hydrocarbons on activities of hepatic phase II enzymes in rats. AN - 79497987; 2517257 AB - A series of environmentally occurring nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) including those containing nitro-groups oriented coplanarly to the aromatic rings, such as 1- and 3-nitrobenzo[a]pyrene (1- and 3-NBAP), 6-nitrochrysene, and 1- and 4-nitropyrene, and those with a molecular orientation of the nitro-groups perpendicular to the aromatic moieties, such as 7-nitrobenz[a]anthracene and 6-nitrobenzo[a]pyrene (6-NBAP), were used to study the induction of certain rat hepatic phase II conjugating enzymes. Effects of these two different classes of nitro-PAHs on microsomal UDP-glucuronyltransferase (UDPGT), cytosolic glutathione S-transferases (GSTs) and sulfotransferases (STs) were investigated. After three consecutive daily i.p. injections, 1- and 3-NBAP and 6-nitrochrysene significantly increased the activities of UDPGT and GST, whereas their parent PAHs did not induce UDPGT (and GST activity was also unaltered by benzo[a]pyrene). UDPGT and GST activities were also significantly increased by 1-nitropyrene. In contrast, the sulfotransferases directed to 2-naphthol were not significantly induced by any PAH or nitro-PAH when assayed at either pH 5.5 or 7.5; however, the activities of aryl STs III and IV (pH 5.5) were significantly decreased following treatment with pyrene and two nitro-compounds, 6-NBAP and 7-nitrobenz[a]anthracene, in which the nitro-group is oriented perpendicular to the aromatic moiety. These results indicate that a coplanar orientation of the nitro-group of certain nitrated PAHs facilitates the induction of hepatic phase II enzymes by these compounds in rats, and the comparable induction patterns for P450IA1, UDPGT, and GST provide further evidence supporting the coordinate regulation (through the Ah receptor) of these phase I and phase II activities. JF - Drug and chemical toxicology AU - Pegram, R A AU - Chou, M W AD - Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. PY - 1989 SP - 313 EP - 326 VL - 12 IS - 3-4 SN - 0148-0545, 0148-0545 KW - Benzopyrenes KW - 0 KW - Nitrobenzenes KW - Polycyclic Compounds KW - 3-nitrobenzo(a)pyrene KW - 70021-98-6 KW - 1-nitrobenzo(a)pyrene KW - 70021-99-7 KW - 1,2-dichloro-4-nitrobenzene KW - 99-54-7 KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Arylsulfotransferase KW - EC 2.8.2.1 KW - Dinitrochlorobenzene KW - GE3IBT7BMN KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dinitrochlorobenzene -- metabolism KW - Environmental Exposure KW - Enzyme Induction KW - Benzopyrenes -- metabolism KW - Nitrobenzenes -- metabolism KW - Male KW - Liver -- enzymology KW - Glutathione Transferase -- metabolism KW - Glucuronosyltransferase -- metabolism KW - Polycyclic Compounds -- metabolism KW - Arylsulfotransferase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79497987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Effect+of+nitro-substitution+of+environmental+polycyclic+aromatic+hydrocarbons+on+activities+of+hepatic+phase+II+enzymes+in+rats.&rft.au=Pegram%2C+R+A%3BChou%2C+M+W&rft.aulast=Pegram&rft.aufirst=R&rft.date=1989-09-01&rft.volume=12&rft.issue=3-4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-21 N1 - Date created - 1990-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Postnatal function following prenatal reserpine exposure in rats: neurobehavioral toxicity. AN - 79370194; 2593990 AB - Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on days 12, 16 and 20, and auditory startle habituation on day 19 or 20. In addition, brains were removed from culled pups on day 1, 1 male and 1 female/litter on day 8, and animals tested for activity on day 21. Neurochemical assays were performed on whole brains from 1- and 8-day-old pups, and on caudate nucleus, frontal cortex and hippocampus of day 21 rats. Treatment resulted in dose-related decreases in maternal weight gain over gestation and mean pup weight at birth. Changes in the normal developmental activity pattern were both sex and dose dependent in treated rats. In auditory startle habituation experiments, rats exhibited a dose-related decrease in response amplitude and rate of habituation. In the day 21 females, caudate nucleus dopamine (DA) and serotonin (5-HT) concentrations and DA-receptor binding were decreased in a dose-dependent manner. Males showed less dramatic, but similar trends in caudate changes. However, hippocampal 5-HT and 5-HT receptor binding were significantly reduced only in females. Thus, sex-related behavioral alterations were accompanied by sex-related neurochemical changes, and females generally were more affected than males by prenatal reserpine treatment. The significant decrease in activity and auditory startle amplitude in the females is consistent with the suggested down regulation of the DA system in regional brain areas. JF - Neurotoxicology and teratology AU - Buelke-Sam, J AU - Ali, S F AU - Kimmel, G L AU - Slikker, W AU - Newport, G D AU - Harmon, J R AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. PY - 1989 SP - 515 EP - 522 VL - 11 IS - 5 SN - 0892-0362, 0892-0362 KW - Biogenic Monoamines KW - 0 KW - Reserpine KW - 8B1QWR724A KW - Index Medicus KW - Rats KW - Animals KW - Biogenic Monoamines -- metabolism KW - Male KW - Female KW - Pregnancy KW - Behavior, Animal -- drug effects KW - Brain Chemistry -- drug effects KW - Reserpine -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79370194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Postnatal+function+following+prenatal+reserpine+exposure+in+rats%3A+neurobehavioral+toxicity.&rft.au=Buelke-Sam%2C+J%3BAli%2C+S+F%3BKimmel%2C+G+L%3BSlikker%2C+W%3BNewport%2C+G+D%3BHarmon%2C+J+R&rft.aulast=Buelke-Sam&rft.aufirst=J&rft.date=1989-09-01&rft.volume=11&rft.issue=5&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-17 N1 - Date created - 1990-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemical test for mammalian feces in grain products: collaborative study. AN - 79289531; 2808238 AB - A collaborative study was conducted to validate the use of the AOAC alkaline phosphatase method for mammalian feces in corn meal, 44.B01-44.B06, for 7 additional products: brown rice cream, oat bran, grits, semolina, pasta flour, farina, and barley plus (a mixture of barley, oat bran, and brown rice). The proposed method determines the presence of alkaline phosphatase, an enzyme contained in mammalian feces, by using phenolphthalein diphosphate as the enzyme substrate in a test agar medium. Fecal matter is separated from the grain products by specific gravity differences in 1% test agar. As the product is distributed on liquid test agar, fecal fragments float while the grain products sink. The alkaline phosphatase cleaves phosphate radicals from phenolphthalein diphosphate, generating free phenolphthalein, which produces a pink to red-purple color around the fecal particles in the previously colorless medium. Collaborators' recovery averages ranged from 21.7 particles (72.3%) for oat bran to 25.3 particles (84.3%) for semolina at the 30 particle spike level. Overall average background was 0.4 positive reactions per food type. The collaborators reported that the method was quick, simple, and easy to use. The method has been approved interim official first action for all 7 grain products. JF - Journal - Association of Official Analytical Chemists AU - Gerber, H R AD - Food and Drug Administration, Division of Microbiology, Washington, DC 20204. PY - 1989 SP - 766 EP - 769 VL - 72 IS - 5 SN - 0004-5756, 0004-5756 KW - Culture Media KW - 0 KW - Indicators and Reagents KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Oryza -- analysis KW - Animals KW - Mammals KW - Alkaline Phosphatase -- analysis KW - Hordeum -- analysis KW - Zea mays -- analysis KW - Triticum -- analysis KW - Feces -- analysis KW - Flour -- analysis KW - Food Contamination -- analysis KW - Edible Grain -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79289531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Chemical+test+for+mammalian+feces+in+grain+products%3A+collaborative+study.&rft.au=Gerber%2C+H+R&rft.aulast=Gerber&rft.aufirst=H&rft.date=1989-09-01&rft.volume=72&rft.issue=5&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-04 N1 - Date created - 1989-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modified liquid chromatographic method for determination of gentian violet in animal feed. AN - 79288860; 2808234 AB - A modified liquid chromatographic method is described for the determination of Gentian Violet (GV) in animal feed. The reliable detection limit is 0.5 ng (reference standards), and 1 ppm GV was reliably determined in feed. The calibration curve was linear between 1 and 40 micrograms/mL. The method, developed in a study by the National Center for Toxicological Research, was modified to use methanol-water (9 + 1) instead of benzene-methanol as the eluting solution in the column cleanup. GV is extracted from feed with methanol-1N HCl (99 + 1), cleaned up on a Sephadex LH-20 column to remove any remaining interferences, separated on a Nova-Pak C18 column fitted with a precolumn filter, and determined at 588 nm. The identity of GV is confirmed by thin-layer chromatography (Rf = 0.47) by comparison with a reference standard. Average recoveries from 3 sets of 5 feed samples containing 2.5, 5.0, and 10.0 ppm GV were 115, 95, and 102%, respectively. JF - Journal - Association of Official Analytical Chemists AU - Martinez, E E AU - Shimoda, W AD - Food and Drug Administration, Denver Federal Center, CO 80225-0087. PY - 1989 SP - 742 EP - 745 VL - 72 IS - 5 SN - 0004-5756, 0004-5756 KW - Indicators and Reagents KW - 0 KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Reference Standards KW - Chromatography, Liquid KW - Chromatography, Thin Layer KW - Animal Feed -- analysis KW - Gentian Violet -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79288860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Modified+liquid+chromatographic+method+for+determination+of+gentian+violet+in+animal+feed.&rft.au=Martinez%2C+E+E%3BShimoda%2C+W&rft.aulast=Martinez&rft.aufirst=E&rft.date=1989-09-01&rft.volume=72&rft.issue=5&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-04 N1 - Date created - 1989-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Liquid chromatographic determination of epimerization of chlortetracycline residue to 4-epi-chlortetracycline residue in animal feed, using McIlvain's buffer as extractant. AN - 79285545; 2808249 AB - A method for studying McIlvain's solution as a factor in epimerization of chlortetracycline in animal feed has been developed. McIlvain's solution (McBuffer) was used previously to extract oxytetracycline (OTC), tetracycline-HCl (TC-HCl), and chlortetracycline-HCl (CTC-HCl) from animal feed because it gave the best recoveries for all 3 tetracyclines; however, the McBuffer solution caused epimerization of CTC-HCl to 4-epi-chlortetracycline (4-epi-CTC). Recovery results were 30-40% lower for CTC than for OTC and TC from the same sample extract. The levels of concentration tested for CTC and 4-epi-CTC were 10 ppm, the detection limits for both were 3 ppb, and the calibration curves were linear between 5 and 80 ppm for both CTC-HCl and 4-epi-CTC. The present study shows that CTC recoveries averaged 35% lower because of epimerization initiated by the use of McBuffer in the extraction procedure. JF - Journal - Association of Official Analytical Chemists AU - Martinez, E E AU - Shimoda, W AD - Food and Drug Administration, Denver Federal Center, CO 80225. PY - 1989 SP - 848 EP - 850 VL - 72 IS - 5 SN - 0004-5756, 0004-5756 KW - Buffers KW - 0 KW - Indicators and Reagents KW - Chlortetracycline KW - WCK1KIQ23Q KW - Oxytetracycline KW - X20I9EN955 KW - Index Medicus KW - Stereoisomerism KW - Reference Standards KW - Chromatography, Liquid KW - Oxytetracycline -- analysis KW - Drug Residues -- analysis KW - Chlortetracycline -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79285545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Liquid+chromatographic+determination+of+epimerization+of+chlortetracycline+residue+to+4-epi-chlortetracycline+residue+in+animal+feed%2C+using+McIlvain%27s+buffer+as+extractant.&rft.au=Martinez%2C+E+E%3BShimoda%2C+W&rft.aulast=Martinez&rft.aufirst=E&rft.date=1989-09-01&rft.volume=72&rft.issue=5&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-04 N1 - Date created - 1989-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. AN - 79270452; 2802607 AB - The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the application of UV absorption, 1H nuclear magnetic resonance, and mass spectral techniques. The results show that aromatic ring oxidation followed by glucosylation is a predominant pathway in the metabolism of the polycyclic aromatic hydrocarbon phenanthrene by C. elegans. JF - Applied and environmental microbiology AU - Cerniglia, C E AU - Campbell, W L AU - Freeman, J P AU - Evans, F E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 2275 EP - 2279 VL - 55 IS - 9 SN - 0099-2240, 0099-2240 KW - Phenanthrenes KW - 0 KW - Index Medicus KW - Acetylation KW - Biodegradation, Environmental KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Phenanthrenes -- metabolism KW - Phenanthrenes -- isolation & purification KW - Mucorales -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79270452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Identification+of+a+novel+metabolite+in+phenanthrene+metabolism+by+the+fungus+Cunninghamella+elegans.&rft.au=Cerniglia%2C+C+E%3BCampbell%2C+W+L%3BFreeman%2C+J+P%3BEvans%2C+F+E&rft.aulast=Cerniglia&rft.aufirst=C&rft.date=1989-09-01&rft.volume=55&rft.issue=9&rft.spage=2275&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-31 N1 - Date created - 1989-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Chem Soc. 1976 Sep 15;98(19):5988-96 [965633] Biochem Pharmacol. 1978;27(14):1865-71 [708468] Chem Biol Interact. 1983 Apr-May;44(1-2):119-32 [6406078] Biochem J. 1962 Sep;84:571-82 [13872198] Adv Appl Microbiol. 1984;30:31-71 [6442534] Appl Environ Microbiol. 1985 Sep;50(3):649-55 [3907498] Appl Environ Microbiol. 1987 Oct;53(10):2560-6 [3122656] Appl Environ Microbiol. 1984 Jan;47(1):119-24 [6696409] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pesticides and food safety. AN - 79199508; 2773760 JF - American family physician AU - Nightingale, S L AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 289 EP - 290 VL - 40 IS - 3 SN - 0002-838X, 0002-838X KW - Pesticide Residues KW - 0 KW - Pesticides KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Safety KW - Pesticide Residues -- analysis KW - Food Contamination -- analysis KW - Food -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Pesticides+and+food+safety.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1989-09-01&rft.volume=40&rft.issue=3&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-28 N1 - Date created - 1989-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reply to 'Comment on the Non-Additivity of the Mutagenic Response of Mixtures of Nitrobenzo[a]Pyrenes'. AN - 79194049; 2671719 JF - Mutation research AU - Heflich, R H AU - Hass, B S AU - Chen, J J AU - Thornton-Manning, J R AU - Fu, P P AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 69 EP - 71 VL - 227 IS - 1 SN - 0027-5107, 0027-5107 KW - Benzopyrenes KW - 0 KW - 3-nitrobenzo(a)pyrene KW - 70021-98-6 KW - 1-nitrobenzo(a)pyrene KW - 70021-99-7 KW - Index Medicus KW - Mutagenicity Tests KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Benzopyrenes -- pharmacology KW - Salmonella typhimurium -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79194049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Reply+to+%27Comment+on+the+Non-Additivity+of+the+Mutagenic+Response+of+Mixtures+of+Nitrobenzo%5Ba%5DPyrenes%27.&rft.au=Heflich%2C+R+H%3BHass%2C+B+S%3BChen%2C+J+J%3BThornton-Manning%2C+J+R%3BFu%2C+P+P&rft.aulast=Heflich&rft.aufirst=R&rft.date=1989-09-01&rft.volume=227&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-06 N1 - Date created - 1989-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of tetrandrine on micronucleus formation and sister-chromatid exchange in both in vitro and in vivo assays. AN - 79186048; 2770774 AB - The genotoxicity of tetrandrine, a drug potentially useful for the treatment of silicosis, was studied using the micronucleus and the sister-chromatid exchange (SCE) assay systems. Cultured Chinese hamster lung (V79) cells were used for the in vitro micronucleus and sister-chromatid exchange studies. Mouse bone marrow was used for the in vivo micronucleus assay and mouse spleen cells for the in vivo/in vitro sister-chromatid exchange analysis. The results show that SCE levels in V79 and in spleen cells were significantly elevated by treatment with tetrandrine at doses above 0.08 mg/ml and 100 mg/kg bw, respectively. Increased tetradrine-induced SCE in vitro was metabolic activation dependent. Tetrandrine failed to induce micronuclei at any of the doses tested. A decrease of replicative index with an increase in the concentration of tetrandrine was found both in vitro and in vivo. These results indicate that tetrandrine is a weak indirect-acting genotoxicant. JF - Mutation research AU - Xing, S G AU - Shi, X C AU - Wu, Z L AU - Whong, W Z AU - Ong, T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 5 EP - 10 VL - 224 IS - 1 SN - 0027-5107, 0027-5107 KW - Alkaloids KW - 0 KW - Benzylisoquinolines KW - tetrandrine KW - 29EX23D5AJ KW - Index Medicus KW - Fibroblasts -- drug effects KW - Animals KW - Spleen -- cytology KW - Biotransformation KW - Humans KW - Cell Division -- drug effects KW - Middle Aged KW - Mice KW - Spleen -- drug effects KW - Bone Marrow -- ultrastructure KW - Bone Marrow -- drug effects KW - Male KW - Micronucleus Tests KW - Sister Chromatid Exchange -- drug effects KW - Alkaloids -- toxicity KW - Alkaloids -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79186048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Effect+of+tetrandrine+on+micronucleus+formation+and+sister-chromatid+exchange+in+both+in+vitro+and+in+vivo+assays.&rft.au=Xing%2C+S+G%3BShi%2C+X+C%3BWu%2C+Z+L%3BWhong%2C+W+Z%3BOng%2C+T&rft.aulast=Xing&rft.aufirst=S&rft.date=1989-09-01&rft.volume=224&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-06 N1 - Date created - 1989-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neonatal anuria with maternal angiotensin-converting enzyme inhibition. AN - 79138850; 2761913 AB - The use of angiotensin-converting enzyme inhibitors as antihypertensives has increased rapidly since the introduction of captopril in 1981. Seven cases of neonatal renal failure have been reported in patients with exposure to angiotensin-converting enzyme inhibitors that continued to the time of delivery. Two cases resulted in death of the newborn; the other five patients recovered after peritoneal dialysis. Because the relative frequency of normal outcomes is unknown, these data are insufficient for incidence-rate estimates or risk/benefit analyses. However, given the potential neonatal morbidity and mortality associated with late-pregnancy exposure to angiotensin-converting enzyme inhibitors, alternative therapies in the third trimester should be given consideration. If these drugs must be used in this context, the clinician should be prepared to deal with renal failure and hypotension in the newborn. The Food and Drug Administration invites reports of adverse pregnancy outcomes associated with such exposure. JF - Obstetrics and gynecology AU - Rosa, F W AU - Bosco, L A AU - Graham, C F AU - Milstien, J B AU - Dreis, M AU - Creamer, J AD - Food and Drug Administration, Rockville, Maryland. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 371 EP - 374 VL - 74 IS - 3 Pt 1 SN - 0029-7844, 0029-7844 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Creatinine KW - AYI8EX34EU KW - Abridged Index Medicus KW - Index Medicus KW - Hypotension -- chemically induced KW - Maternal-Fetal Exchange KW - Pregnancy Trimester, Third KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Infant, Newborn KW - Creatinine -- blood KW - Female KW - Pregnancy KW - Anuria -- chemically induced KW - Angiotensin-Converting Enzyme Inhibitors -- metabolism KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Pregnancy Complications, Cardiovascular -- drug therapy KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79138850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Neonatal+anuria+with+maternal+angiotensin-converting+enzyme+inhibition.&rft.au=Rosa%2C+F+W%3BBosco%2C+L+A%3BGraham%2C+C+F%3BMilstien%2C+J+B%3BDreis%2C+M%3BCreamer%2C+J&rft.aulast=Rosa&rft.aufirst=F&rft.date=1989-09-01&rft.volume=74&rft.issue=3+Pt+1&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Nutrition monitoring in the United States: an update report on nutrition monitoring T2 - Dept. of Health and Human Services. DHHS pubn. no. (PHS)89-1255 AN - 59509108; 1990-0301425 AB - Prepared by Life Sciences Research Office, Federation of American Societies for Experimental Biology, and published jointly with Food and Consumer Services, US Department of Agriculture. Partial contents: Appropriate uses of survey data in the assessment of dietary and nutrition-related health status; Update of selected health conditions and behaviors: relationship to nutritional status; Nutritional and dietary factors in cardiovascular disease. JF - Supt Docs, September 1989. Y1 - 1989/09// PY - 1989 DA - September 1989 PB - Supt Docs KW - United States KW - Diet KW - Food consumption -- Statistics KW - Nutrition -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59509108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Nutrition+monitoring+in+the+United+States%3A+an+update+report+on+nutrition+monitoring&rft.title=Nutrition+monitoring+in+the+United+States%3A+an+update+report+on+nutrition+monitoring&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Supt Docs (LC 89-14529) pa U.S. $21; elsewhere $26.25 N1 - Document feature - bibl(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Use of the thermotolerant Aeromonas group for the trophic state classification of freshwaters AN - 15945211; 4049208 AB - Data obtained from 68 lakes surveyed in the United States showed a highly significant correlation between the densities of a specific group of autochthonous, heterotrophic bacteria, thermotolerant aeromonads and the trophic state of fresh waters. This measurement provides a sensitive, accurate and facile descriptor of limnetic water quality and shows strong correlations with certain other commonly employed physical, chemical and biological parameters used in this regard. The best correlations were obtained with Secchi depth (r = -0.70), total phosphorus (r = 0.72) and chlorophyll a (r = 0.67). An even stronger correlation was obtained with a trophic index derived from these three parameters (r = -0.84). Alternatively, total heterotrophic bacterial populations, as enumerated by epifluorescence microscopy, were very poorly correlated with all the individual trophic state measurements, and the indices derived from them. An analysis of correlation coefficients for trophic state parameters and indices used for this study indicated that the level of thermotolerant aeromonads was one of the most discriminating single parameters for defining trophic state. The economy of the measurement, coupled with its facility, makes it an exceptionally promising technique for assessing the degree and rate of fresh water eutrophication (DBO). JF - Water Research AU - Rippey AU - Cabelli, V J AD - U.S. Public Health Service, FDA, Davisville, RI 02852, USA Y1 - 1989/09// PY - 1989 DA - Sep 1989 SP - 1107 EP - 1114 VL - 23 IS - 9 SN - 0043-1354, 0043-1354 KW - ASFA 3: Aquatic Pollution & Environmental Quality KW - USA KW - pollution monitoring KW - Aeromonas KW - indicator species KW - physicochemical properties KW - bacteria KW - water quality control KW - Freshwater KW - trophic structure KW - Q5 08504:Effects on organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15945211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Use+of+the+thermotolerant+Aeromonas+group+for+the+trophic+state+classification+of+freshwaters&rft.au=Rippey%3BCabelli%2C+V+J&rft.aulast=Rippey&rft.aufirst=&rft.date=1989-09-01&rft.volume=23&rft.issue=9&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - pollution monitoring; indicator species; bacteria; physicochemical properties; water quality control; trophic structure; Aeromonas; USA; Freshwater ER - TY - JOUR T1 - Glutathione regulates interleukin-2 activity on cytotoxic T-cells. AN - 79126032; 2788161 AB - In this study, we examined whether and how the cellular activity of interleukin-2 (IL-2) is affected by glutathione (GSH), an important tripeptide existing in most cells. Cell culture and thymidine incorporation assay showed that addition of GSH enhanced the effect of IL-2 on the proliferation and thymidine incorporation of IL-2-dependent cytotoxic T-cells such as CTLL-2 and CT-4R. Treatment of the cells with GSH resulted in a 2-fold increase in the amount of IL-2 bound to the cells and a rapid internalization of the bound IL-2. In addition, the degradation of IL-2 in the cells was enhanced by GSH treatment. These effects of GSH were accompanied by an increase in the intracellular GSH level. L-Buthionine-(S,R)-sulfoximine, an inhibitor of de novo GSH synthesis, blunted the increase of intracellular GSH level and modulated the effect of GSH on IL-2 activity. These results suggest that GSH regulates the binding, internalization, degradation, and T-cell proliferative activity of IL-2; alterations of cellular GSH concentration may thus affect the growth and replication of IL-2-sensitive cytotoxic T-cells. JF - The Journal of biological chemistry AU - Liang, C M AU - Lee, N AU - Cattell, D AU - Liang, S M AD - Division of Blood and Blood Products, Food and Drug Administration, Bethesda, Maryland. Y1 - 1989/08/15/ PY - 1989 DA - 1989 Aug 15 SP - 13519 EP - 13523 VL - 264 IS - 23 SN - 0021-9258, 0021-9258 KW - Antimetabolites KW - 0 KW - Interleukin-2 KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Methionine Sulfoximine KW - 1982-67-8 KW - Buthionine Sulfoximine KW - 5072-26-4 KW - Glutathione KW - GAN16C9B8O KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Antimetabolites -- pharmacology KW - Animals KW - Receptors, Interleukin-2 -- metabolism KW - Recombinant Proteins -- pharmacology KW - Kinetics KW - Methionine Sulfoximine -- pharmacology KW - Methionine Sulfoximine -- analogs & derivatives KW - DNA Replication -- drug effects KW - Cell Line KW - Receptors, Interleukin-2 -- drug effects KW - Interleukin-2 -- pharmacology KW - T-Lymphocytes, Cytotoxic -- immunology KW - Glutathione -- pharmacology KW - T-Lymphocytes, Cytotoxic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79126032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Glutathione+regulates+interleukin-2+activity+on+cytotoxic+T-cells.&rft.au=Liang%2C+C+M%3BLee%2C+N%3BCattell%2C+D%3BLiang%2C+S+M&rft.aulast=Liang&rft.aufirst=C&rft.date=1989-08-15&rft.volume=264&rft.issue=23&rft.spage=13519&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung cancer mortality among nonsmoking uranium miners exposed to radon daughters. AN - 79110730; 2746814 AB - Radon daughters, both in the workplace and in the household, are a continuing cause for concern because of the well-documented association between exposure to radon daughters and lung cancer. To estimate the risk of lung cancer mortality among nonsmokers exposed to varying levels of radon daughters, 516 white men who never smoked cigarettes, pipes, or cigars were selected from the US Public Health Service cohort of Colorado Plateau uranium miners and followed up from 1950 through 1984. Age-specific mortality rates for nonsmokers from a study of US veterans were used for comparison. Fourteen deaths from lung cancer were observed among the nonsmoking miners, while 1.1 deaths were expected, yielding a standardized mortality ratio of 12.7 with 95% confidence limits of 8.0 and 20.1. These results confirm that exposure to radon daughters in the absence of cigarette smoking is a potent carcinogen that should be strictly controlled. JF - JAMA AU - Roscoe, R J AU - Steenland, K AU - Halperin, W E AU - Beaumont, J J AU - Waxweiler, R J AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/08/04/ PY - 1989 DA - 1989 Aug 04 SP - 629 EP - 633 VL - 262 IS - 5 SN - 0098-7484, 0098-7484 KW - Uranium KW - 4OC371KSTK KW - Radon KW - Q74S4N8N1G KW - Abridged Index Medicus KW - Index Medicus KW - Veterans KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Environmental Exposure KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Lung Diseases -- mortality KW - Colorado KW - Time Factors KW - Male KW - Smoking KW - Lung Neoplasms -- mortality KW - Mining KW - Lung Neoplasms -- chemically induced KW - Radon -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79110730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Lung+cancer+mortality+among+nonsmoking+uranium+miners+exposed+to+radon+daughters.&rft.au=Roscoe%2C+R+J%3BSteenland%2C+K%3BHalperin%2C+W+E%3BBeaumont%2C+J+J%3BWaxweiler%2C+R+J&rft.aulast=Roscoe&rft.aufirst=R&rft.date=1989-08-04&rft.volume=262&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-21 N1 - Date created - 1989-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1989 Dec 22-29;262(24):3403-4 [2585685] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicology of medical device material. AN - 79228853; 2792590 AB - The 1976 amendments to the Food, Drug, and Cosmetic Act established requirements for obtaining approval to market new medical devices, including the necessity for demonstrating safety and effectiveness. Evaluation of the potential toxicity of medical devices presents toxicologists with unique problems related to route of exposure, estimation of exposure dose, exposure to by-products generated during manufacture, and matrix effects. A symposium was organized to address the need for toxicologists to examine the potential toxicities of medical device materials, to appreciate the unique problems associated with medical device safety evaluation, to present novel testing methodologies, and to discuss future research needs. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Goering, P L AU - Galloway, W D AD - Division of Life Sciences, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 193 EP - 195 VL - 13 IS - 2 SN - 0272-0590, 0272-0590 KW - Biocompatible Materials KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Risk Factors KW - Legislation, Medical KW - Biocompatible Materials -- toxicity KW - Equipment and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79228853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Toxicology+of+medical+device+material.&rft.au=Goering%2C+P+L%3BGalloway%2C+W+D&rft.aulast=Goering&rft.aufirst=P&rft.date=1989-08-01&rft.volume=13&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-28 N1 - Date created - 1989-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Listeria spp. found on fresh market produce. AN - 79215311; 2506809 AB - From October 1987 to August 1988, 1,000 tests were conducted on 10 types of fresh produce from two Minneapolis area supermarkets to detect Listeria spp. The produce included broccoli, cabbage, carrots, cauliflower, cucumbers, lettuce, mushrooms, potatoes, radishes, and tomatoes. The vegetables were tested by the Food and Drug Administration method for isolation of Listeria spp., with the addition of LiCl-phenylethanol-moxalactam agar in the last 280 tests; 8.6 and 11.4% of these tests were positive by modified McBride and LiCl-phenylethanol-moxalactam agars, respectively. Listeria monocytogenes was isolated from cabbage, cucumbers, potatoes, and radishes; L. innocua was isolated from cucumbers, lettuce, mushrooms, potatoes, and radishes; L. seeligeri was isolated from cabbage and radishes; and L. welshimeri was isolated from cucumbers, potatoes, and radishes. The isolates were of various serotypes; however, the L. monocytogenes isolates were predominantly serotype 1 (82%). Only potatoes (25.8% positive) and radishes (30.3% positive) showed significant amounts of L. monocytogenes contamination. JF - Applied and environmental microbiology AU - Heisick, J E AU - Wagner, D E AU - Nierman, M L AU - Peeler, J T AD - Center for Microbiological Investigations, Food and Drug Administration, Minneapolis, Minnesota 55401. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1925 EP - 1927 VL - 55 IS - 8 SN - 0099-2240, 0099-2240 KW - Index Medicus KW - Vegetables KW - Listeria monocytogenes -- isolation & purification KW - Food Microbiology KW - Listeria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79215311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Listeria+spp.+found+on+fresh+market+produce.&rft.au=Heisick%2C+J+E%3BWagner%2C+D+E%3BNierman%2C+M+L%3BPeeler%2C+J+T&rft.aulast=Heisick&rft.aufirst=J&rft.date=1989-08-01&rft.volume=55&rft.issue=8&rft.spage=1925&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-26 N1 - Date created - 1989-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Intern Med. 1986 Mar;146(3):520-4 [3954524] Appl Environ Microbiol. 1986 Nov;52(5):1215-7 [3024563] Appl Environ Microbiol. 1988 Dec;54(12):3003-7 [3146947] N Engl J Med. 1983 Jan 27;308(4):203-6 [6401354] Appl Environ Microbiol. 1988 Dec;54(12):2933-7 [3146945] J Assoc Off Anal Chem. 1988 May-Jun;71(3):658-60 [3134338] J Assoc Off Anal Chem. 1988 May-Jun;71(3):664-8 [3134340] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Locations of fatal work injuries in the United States: 1980 to 1985. AN - 79136212; 2760694 AB - Surveillance of injury at work is beset with problems of method and definition. As a result, national agencies have widely varying estimates of the number of fatal work injuries in the United States. One plausible method for identifying fatal work injuries is to use the Place of Injury variable, which is entered on all US death certificates but is not encoded by the National Center for Health Statistics. To use this method, one would assume that work injuries largely occur at "typical work sites," ie, places coded as industrial, farm, and mine and quarry. Data to test this method were derived from the National Traumatic Occupational Fatality data base maintained by the National Institute for Occupational Safety and Health. Analysis of this data base showed that work-related fatal injuries mostly occur in places where many non-work-related injuries also occur. Only about one third of fatal work injuries took place at locations coded as industrial, farm, and mine and quarry. As a method for identifying fatal work injuries, the Place of Injury variable appears to have little value. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Trent, R B AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 674 EP - 676 VL - 31 IS - 8 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - United States KW - Prospective Studies KW - Humans KW - Wounds and Injuries -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79136212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Locations+of+fatal+work+injuries+in+the+United+States%3A+1980+to+1985.&rft.au=Trent%2C+R+B&rft.aulast=Trent&rft.aufirst=R&rft.date=1989-08-01&rft.volume=31&rft.issue=8&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lead absorption in indoor firing range users. AN - 79115526; 2751019 AB - To determine if users of indoor firing ranges may be at risk from lead exposure, we studied a law enforcement trainee class during three months of firearms instruction. Blood lead levels were obtained before training and at four-week intervals during training. Air lead levels were measured three times during instruction. Blood lead levels rose from a pre-training mean of 0.31 mumol/L to 2.47 mumol/L. Mean air lead levels were above 2,000 micrograms/m3, more than 40 times the Occupational Safety and Health Administration's standard of 50 micrograms/m3. Cumulative exposure to lead and the change in blood lead were positively correlated. Control measures need to be studied to determine their efficacy in decreasing or eliminating this health risk. JF - American journal of public health AU - Valway, S E AU - Martyny, J W AU - Miller, J R AU - Cook, M AU - Mangione, E J AD - Diabetes Program, Indian Health Service, Albuquerque, NM 87102. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1029 EP - 1032 VL - 79 IS - 8 SN - 0090-0036, 0090-0036 KW - Air Pollutants KW - 0 KW - Porphyrins KW - Lead KW - 2P299V784P KW - Abridged Index Medicus KW - Index Medicus KW - Ventilation KW - Humans KW - Environmental Exposure KW - Porphyrins -- blood KW - Air Pollutants -- analysis KW - Colorado KW - Time Factors KW - Firearms KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79115526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Lead+absorption+in+indoor+firing+range+users.&rft.au=Valway%2C+S+E%3BMartyny%2C+J+W%3BMiller%2C+J+R%3BCook%2C+M%3BMangione%2C+E+J&rft.aulast=Valway&rft.aufirst=S&rft.date=1989-08-01&rft.volume=79&rft.issue=8&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-17 N1 - Date created - 1989-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chem. 1978 Sep;24(9):1515-7 [688610] JAMA. 1975 Oct 27;234(4):394-7 [1174370] Clin Chem. 1976 Feb;22(2):221-3 [1248123] J Soc Occup Med. 1976 Oct;26(4):139-40 [979184] Am J Med. 1977 Aug;63(2):306-12 [888851] Am J Public Health. 1987 Nov;77(11):1398-9 [3661790] JAMA. 1979 Mar 16;241(11):1141-4 [762765] Clin Chem. 1979 Mar;25(3):389-93 [262177] Pediatrics. 1983 Aug;72(2):214-9 [6866608] Am J Public Health. 1987 Sep;77(9):1225-6 [3618861] Comment In: Am J Public Health. 1990 Mar;80(3):353-4 [2305926] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Two episodes of acute illness in a machine shop. AN - 79106441; 2751018 AB - Following an explosion in a machine shop and temporary plant closure, on the day the plant returned to full operations a degreaser malfunctioned. Workers in the assembly room were exposed to trichloroethylene levels later estimated to have exceeded 220 ppm (OSHA PEL 100 ppm). The plant was evacuated and the degreaser taken out of operation. Blood testing for carbon monoxide (CO) on five employees found carboxyhemoglobin levels in excess of normal. The plant reopened the following morning. Over the next two weeks, 15 employees were seen by the plant nurses for similar complaints; although all returned to work, their carboxyhemoglobin levels, later found to be inaccurate, were reported by a local medical clinic to range from 13.7 to 20.0 percent. At the end of the second week, another outbreak of illness occurred, but carboxyhemoglobin, trichloroethylene, fluorocarbons, and methylene chloride were not elevated in all 17 persons tested; plant-wide monitoring for CO found no elevated levels. During the first outbreak of illness, cases were 2.26 times as likely to have entered the assembly room as noncases. During the second outbreak, cases were no more likely than noncases to have entered the assembly room. We believe the explosion, earlier toxic exposures and illness, and the misleading blood test results led to plant-wide anxiety which culminated in a collective stress reaction and the second outbreak. An open meeting with all employees, informing them of our findings, provided reassurance and no further episodes of illness occurred in this workforce. JF - American journal of public health AU - Sinks, T AU - Kerndt, P R AU - Wallingford, K M AD - Hazards Evaluations and Technical Assistance Branch, NIOSH, CDC, Cincinnati, OH 45226-2998. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1024 EP - 1028 VL - 79 IS - 8 SN - 0090-0036, 0090-0036 KW - Trichloroethylene KW - 290YE8AR51 KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Anxiety -- psychology KW - Sex Factors KW - Trichloroethylene -- adverse effects KW - Humans KW - Diagnostic Errors KW - Headache -- chemically induced KW - Adult KW - Environmental Exposure KW - Middle Aged KW - Mass Behavior KW - Time Factors KW - Female KW - Male KW - Carbon Monoxide Poisoning -- etiology KW - Carbon Monoxide Poisoning -- blood KW - Disease Outbreaks KW - Carbon Monoxide Poisoning -- psychology KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79106441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Two+episodes+of+acute+illness+in+a+machine+shop.&rft.au=Sinks%2C+T%3BKerndt%2C+P+R%3BWallingford%2C+K+M&rft.aulast=Sinks&rft.aufirst=T&rft.date=1989-08-01&rft.volume=79&rft.issue=8&rft.spage=1024&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-17 N1 - Date created - 1989-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1978 Apr 3;239(14):1401-2 [633542] J Occup Med. 1978 Jun;20(6):399-400 [671116] J Behav Med. 1979 Sep;2(3):297-309 [537040] J Occup Med. 1987 Feb;29(2):148-50 [3819896] J Occup Med. 1984 May;26(5):381-5 [6726487] Arch Intern Med. 1984 Oct;144(10):1945-6 [6486979] J Occup Med. 1985 Dec;27(12):867-72 [3910765] J Occup Med. 1981 Jan;23(1):22-6 [7225196] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Shattuck lecture--the health care priorities of the Bush administration. AN - 79020553; 2499789 JF - The New England journal of medicine AU - Sullivan, L W AD - Department of Health and Human Services, Washington, DC 20201. Y1 - 1989/07/13/ PY - 1989 DA - 1989 Jul 13 SP - 125 EP - 128 VL - 321 IS - 2 SN - 0028-4793, 0028-4793 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - United States KW - Health Services for the Aged -- legislation & jurisprudence KW - Health Expenditures -- legislation & jurisprudence KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Poverty KW - Humans KW - Financing, Government -- legislation & jurisprudence KW - Long-Term Care -- economics KW - Aged KW - Research KW - Health Education KW - Substance-Related Disorders -- prevention & control KW - Health Priorities -- legislation & jurisprudence KW - Health Planning -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79020553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Shattuck+lecture--the+health+care+priorities+of+the+Bush+administration.&rft.au=Sullivan%2C+L+W&rft.aulast=Sullivan&rft.aufirst=L&rft.date=1989-07-13&rft.volume=321&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Measurements of lipopolysaccharide (endotoxin) in meningococcal protein and polysaccharide preparations for vaccine usage. AN - 79234711; 2477374 AB - Lipopolysaccharide (LPS, i.e. endotoxin) present in meningococcal outer-membrane protein and polysaccharide preparations made for vaccine use was quantitated by a silver-stain method following SDS-PAGE. The reactivities of LPS in the preparations were also measured by rabbit pyrogenicity and Limulus amoebocyte lysate (LAL) assay. Although rabbit pyrogenicity and LAL assay are more sensitive than the silver stain method, the latter provided an actual amount of LPS present in the protein or in the polysaccharide. For a meningococcal protein preparation, rabbit pyrogenicity showed about one-tenth, and even less by LAL assay, of the actual amount of LPS. This is because protein-bound LPS in meningococcal protein preparations is about 10-fold less active in causing fever in rabbits, and 20- to 40-fold less active in the gelation of LAL than the same amount of a purified free LPS which is generally used as a reference in quantitating LPS in these two assays. As for the small amount of LPS present in a meningococcal polysaccharide preparation, similar LPS content was obtained when measured by the three methods suggesting that the LPS is not bound to the polysaccharide in contrast to that in the proteins mentioned above. The purified meningococcal LPS was pyrogenic in rabbits at 1 ng/kg. JF - Journal of biological standardization AU - Tsai, C M AU - Frasch, C E AU - Rivera, E AU - Hochstein, H D AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 249 EP - 258 VL - 17 IS - 3 SN - 0092-1157, 0092-1157 KW - Bacterial Outer Membrane Proteins KW - 0 KW - Bacterial Vaccines KW - Lipopolysaccharides KW - Meningococcal Vaccines KW - Polysaccharides, Bacterial KW - Pyrogens KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Limulus Test KW - Rabbits KW - Staining and Labeling KW - Polysaccharides, Bacterial -- analysis KW - Neisseria meningitidis -- growth & development KW - Bacterial Outer Membrane Proteins -- analysis KW - Lipopolysaccharides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79234711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biological+standardization&rft.atitle=Measurements+of+lipopolysaccharide+%28endotoxin%29+in+meningococcal+protein+and+polysaccharide+preparations+for+vaccine+usage.&rft.au=Tsai%2C+C+M%3BFrasch%2C+C+E%3BRivera%2C+E%3BHochstein%2C+H+D&rft.aulast=Tsai&rft.aufirst=C&rft.date=1989-07-01&rft.volume=17&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Journal+of+biological+standardization&rft.issn=00921157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-01 N1 - Date created - 1989-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic toxicity/carcinogenicity studies of sulphamethazine in B6C3F1 mice. AN - 79199687; 2777149 AB - A chronic feeding study was carried out in B6C3F1 mice with sulphamethazine (SMZ). The test substance was administered in the diet at dose levels of 0 (control), 300, 600, 1200, 2400 and 4800 ppm for 24 months. Mice were killed after 12, 18 and 24 months of continuous dosing. Body weights and food consumption were measured weekly, and mortality was recorded daily. All animals received a complete necropsy and histopathological examination, the results of which were analysed statistically. A slight decrease in body-weight gain was noted for mice of all dose groups with females showing the greater effect. Food consumption based on g food/g average body weight was relatively constant among the controls and various dose groups. The mortality rate for males and females of the control groups (8 and 8%, respectively) was higher than that for males and females of some of the higher dose groups. Neoplastic lesions associated with the ingestion of SMZ in the diet included follicular cell adenomas of the thyroid gland. At the 24-month necropsy, the incidence of this lesion for males and females of the 4800-ppm dose groups was 33 and 26%, respectively. Non-neoplastic dose-related lesions observed in both males and females included follicular cell hyperplasia (diffuse and focal) of the thyroid gland, haematopoietic cell proliferation of the spleen and pigmentation of the spleen. In females, pigmentation of the lymph nodes and hyperplasia of the mammary gland were also noted. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Littlefield, N A AU - Gaylor, D W AU - Blackwell, B N AU - Allen, R R AD - Department of Health and Human Services, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 455 EP - 463 VL - 27 IS - 7 SN - 0278-6915, 0278-6915 KW - Carcinogens KW - 0 KW - Sulfamethazine KW - 48U51W007F KW - Index Medicus KW - Eating KW - Animals KW - Hyperplasia -- chemically induced KW - Mammary Glands, Animal -- drug effects KW - Dose-Response Relationship, Drug KW - Mammary Glands, Animal -- pathology KW - Body Weight -- drug effects KW - Spleen -- pathology KW - Mice KW - Diet KW - Spleen -- drug effects KW - Time Factors KW - Male KW - Female KW - Thyroid Neoplasms -- chemically induced KW - Adenoma -- chemically induced KW - Sulfamethazine -- toxicity KW - Sulfamethazine -- administration & dosage KW - Liver Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Chronic+toxicity%2Fcarcinogenicity+studies+of+sulphamethazine+in+B6C3F1+mice.&rft.au=Littlefield%2C+N+A%3BGaylor%2C+D+W%3BBlackwell%2C+B+N%3BAllen%2C+R+R&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1989-07-01&rft.volume=27&rft.issue=7&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-25 N1 - Date created - 1989-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction of the B subunit of cholera toxin with endogenous ganglioside GM1 causes changes in membrane potential of rat thymocytes. AN - 79185848; 2769735 AB - The fluorescent anionic dye, bisoxonol, and flow cytometry have been used to monitor changes in the membrane potential of rat thymocytes exposed to the B subunit of cholera toxin. The B subunit induced a rapid hyperpolarization, which was due to activation of a Ca2+-sensitive K+ channel. Reduction of extracellular Ca2+ to less than 1 microM by the addition of [ethylene-bis(oxyethylenenitrilo)]tetraacetic acid immediately abolished the hyperpolarization caused by the B subunit. Cells treated with quinine and tetraethylammonium lost their ability to respond to the B subunit, whereas 4-aminopyridine did not have any effect. Thus, calcium-sensitive and not voltage-gated K+ channels appeared to be responsible for the hyperpolarization. The results of ion substitution experiments indicated that extracellular Na+ was not essential for changes in membrane potential. Further studies with ouabain, amiloride and furosemide demonstrated that electrogenic Na+/K+ ATPase, Na+/H+ antiporter and Na+/K+/Cl- cotransporter, respectively, were not involved in the hyperpolarization process induced by the B subunit. Thus, crosslinking of several molecules of ganglioside GM1 on the cell surface of rat thymocytes by the pentavalent B subunit of cholera toxin modulated plasma membrane permeability to K+ by triggering the opening of Ca2+-sensitive K+ channels. A role for gangliosides in regulating ion permeability would have important implications for the function of gangliosides in various cellular phenomena. JF - The Journal of membrane biology AU - Mulhern, S A AU - Fishman, P H AU - Spiegel, S AD - Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 21 EP - 28 VL - 109 IS - 1 SN - 0022-2631, 0022-2631 KW - Potassium Channels KW - 0 KW - Concanavalin A KW - 11028-71-0 KW - G(M1) Ganglioside KW - 37758-47-7 KW - Cholera Toxin KW - 9012-63-9 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Potassium Channels -- physiology KW - Membrane Potentials -- drug effects KW - Flow Cytometry KW - Potassium Channels -- drug effects KW - Concanavalin A -- pharmacology KW - Thymus Gland -- metabolism KW - Calcium -- physiology KW - G(M1) Ganglioside -- metabolism KW - Thymus Gland -- physiology KW - Cholera Toxin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79185848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+membrane+biology&rft.atitle=Interaction+of+the+B+subunit+of+cholera+toxin+with+endogenous+ganglioside+GM1+causes+changes+in+membrane+potential+of+rat+thymocytes.&rft.au=Mulhern%2C+S+A%3BFishman%2C+P+H%3BSpiegel%2C+S&rft.aulast=Mulhern&rft.aufirst=S&rft.date=1989-07-01&rft.volume=109&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+membrane+biology&rft.issn=00222631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-27 N1 - Date created - 1989-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Liquid chromatographic determination and gas chromatographic-mass spectrometric confirmation of lasalocid sodium in bovine liver: interlaboratory study. AN - 79143684; 2759990 AB - An analytical method has been developed that can reliably measure the metabolic marker residue of lasalocid. The method monitors this marker residue in food samples to ensure that the total residue of toxicological concern is not being exceeded. Interlaboratory studies of the liquid chromatographic determinative procedure and the gas chromatographic/mass spectrometric confirmatory procedure for lasalocid sodium at the 0.7 ppm level and higher were successful. JF - Journal - Association of Official Analytical Chemists AU - Newkirk, D R AU - Barnes, C J AD - Food and Drug Administration, Center for Veterinary Medicine, Rockville, MD 20857. PY - 1989 SP - 581 EP - 584 VL - 72 IS - 4 SN - 0004-5756, 0004-5756 KW - Indicators and Reagents KW - 0 KW - Lasalocid KW - W7V2ZZ2FWB KW - Index Medicus KW - Animals KW - Cattle KW - Gas Chromatography-Mass Spectrometry KW - Chromatography, Liquid KW - Lasalocid -- analysis KW - Liver -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79143684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Liquid+chromatographic+determination+and+gas+chromatographic-mass+spectrometric+confirmation+of+lasalocid+sodium+in+bovine+liver%3A+interlaboratory+study.&rft.au=Newkirk%2C+D+R%3BBarnes%2C+C+J&rft.aulast=Newkirk&rft.aufirst=D&rft.date=1989-07-01&rft.volume=72&rft.issue=4&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Microbiological survey of selected imported spices and associated fecal pellet specimens. AN - 79140702; 2759995 AB - A microbiological survey was performed on 4 selected imported spices: black peppercorns, white peppercorns, coriander, and fennel seed. Aerobic plate count values ranged from 10(4) to 10(7) colony-forming units (CFU)/g for black and white peppercorns and from 10(3) to 10(5) CFU/g for coriander and fennel seed. Combined results of the 3-tube most probable number procedure and the API 20E kit indicated the presence of Escherichia coli in 4 test samples of black peppercorns, 1 test sample of white peppercorns, and 1 test sample of coriander. Two test samples of black peppercorns were positive for Salmonella contamination. Among the various Enterobacteriaceae isolated from the spices, Enterobacter cloacae and Klebsiella pneumoniae were found most frequently in all spice types. Of 18 mammalian and avian fecal pellets removed from the spices and analyzed microbiologically, E. coli was found in only 2 pellet specimens. There was no apparent relationship between the enteric microflora found in spices and those found in the fecal pellets. JF - Journal - Association of Official Analytical Chemists AU - Satchell, F B AU - Bruce, V R AU - Allen, G AU - Andrews, W H AU - Gerber, H R AD - Food and Drug Administration, Division of Microbiology, Washington, DC 20204. PY - 1989 SP - 632 EP - 637 VL - 72 IS - 4 SN - 0004-5756, 0004-5756 KW - Indicators and Reagents KW - 0 KW - Index Medicus KW - Animals KW - Food Contamination KW - Salmonella -- isolation & purification KW - Enterobacteriaceae KW - Feces -- microbiology KW - Food Microbiology KW - Condiments -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79140702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Microbiological+survey+of+selected+imported+spices+and+associated+fecal+pellet+specimens.&rft.au=Satchell%2C+F+B%3BBruce%2C+V+R%3BAllen%2C+G%3BAndrews%2C+W+H%3BGerber%2C+H+R&rft.aulast=Satchell&rft.aufirst=F&rft.date=1989-07-01&rft.volume=72&rft.issue=4&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Microscopic detection and identification of various substitute vegetable tissues in ground horseradish. AN - 79134748; 2759993 AB - Turnip root, parsnip root, potato tuber, and corn kernels have been used as adulterants in the preparation of horseradish sauce and horseradish powder. The diagnostic histological features of horseradish root and its known adulterants are described and illustrated as viewed through a polarizing microscope with cross polars and a first order red plate. A procedure which can be used to detect any of the known adulterants in horseradish is described. The adaptation of a previously reported semiquantitative method is also discussed. JF - Journal - Association of Official Analytical Chemists AU - Galacci, R R AD - Food and Drug Administration, Baltimore, MD 21201. PY - 1989 SP - 619 EP - 621 VL - 72 IS - 4 SN - 0004-5756, 0004-5756 KW - Starch KW - 9005-25-8 KW - Index Medicus KW - Solanum tuberosum -- analysis KW - Starch -- analysis KW - Zea mays -- analysis KW - Microscopy, Polarization KW - Condiments -- analysis KW - Vegetables -- analysis KW - Food Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79134748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Microscopic+detection+and+identification+of+various+substitute+vegetable+tissues+in+ground+horseradish.&rft.au=Galacci%2C+R+R&rft.aulast=Galacci&rft.aufirst=R&rft.date=1989-07-01&rft.volume=72&rft.issue=4&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gamma-ray spectroscopic determination of iodine-131 and cesium-137 in foods: two collaborative studies. AN - 79132784; 2759997 AB - The AOAC method for iodine-131, cesium-137, and barium-140 in milk by gamma-ray spectroscopy (48.025-48.029) was extended to include other foods for the radionuclides iodine-131 and cesium-137. Two collaborative studies were performed to validate this extension. In the first study, a food sample containing 119 pCi 131I/kg and 53 pCi 137Cs/kg was sent to each of 45 laboratories for triplicate analyses. For 25 responses, the mean of the reported values was 123.8 pCi/kg for iodine-131, and for 27 responses, the mean was 53.4 pCi/kg for cesium-137. Repeatability (within-laboratory) standard deviations (Sr) for iodine-131 and cesium-137 were 4.6 and 3.7 pCi/kg, respectively. Reproducibility (among-laboratories) standard deviations (SR) for iodine-131 and cesium-137 were 12.1 and 6.0 pCi/kg, respectively. In the second study, a food sample containing 25 pCi 131I/kg and 27 pCi 137Cs/kg was sent to each of 54 laboratories for triplicate analyses. For 21 responses, the mean of the reported values was 25.0 pCi/kg for iodine-131, and for 19 responses, the mean was 28.9 pCi/kg for cesium-137. Sr Values were 4.0 and 1.6 pCi/kg for iodine-131 and cesium-137, respectively, and SR values were 5.0 and 2.8 pCi/kg, respectively. The method extension was adopted official first action. JF - Journal - Association of Official Analytical Chemists AU - Baratta, E J AU - Easterly, D G AD - Food and Drug Administration, Winchester Engineering and Analytical Center, Winchester, MA 01890. PY - 1989 SP - 667 EP - 669 VL - 72 IS - 4 SN - 0004-5756, 0004-5756 KW - Cesium Radioisotopes KW - 0 KW - Iodine Radioisotopes KW - Index Medicus KW - Animals KW - Cattle KW - Food Contamination KW - Spectrometry, Gamma KW - Milk -- analysis KW - Cesium Radioisotopes -- analysis KW - Food Analysis KW - Iodine Radioisotopes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79132784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Gamma-ray+spectroscopic+determination+of+iodine-131+and+cesium-137+in+foods%3A+two+collaborative+studies.&rft.au=Baratta%2C+E+J%3BEasterly%2C+D+G&rft.aulast=Baratta&rft.aufirst=E&rft.date=1989-07-01&rft.volume=72&rft.issue=4&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Visual and semiquantitative spectrophotometric ELISA screening method for aflatoxin B1 in corn and peanut products: follow-up collaborative study. AN - 79131260; 2503495 AB - A joint AOAC/IUPAC (International Union of Pure and Applied Chemistry) interlaboratory study of an enzyme-linked immunosorbent screening assay (ELISA) for aflatoxins was conducted in laboratories in Canada, France, Japan, The Netherlands, Switzerland, Tunisia, and the United States. Twelve raw and roasted peanut and corn portions containing various concentrations of natural aflatoxins and supplemented when appropriate with aflatoxin B1 were distributed to participating laboratories for testing. The assay is based on competition between an enzyme-conjugated aflatoxin B1 and (free) aflatoxins in the test sample for aflatoxin-specific antibodies coated onto interior surfaces of microtiter wells. After a wash step to remove all unbound aflatoxins, a substrate added to each well is catalyzed from a colorless to a blue solution by any bound enzyme-conjugated aflatoxin B1 present. The intensity of the color decreases as the amount of free aflatoxin B1 in the test portion increases. Final determination of aflatoxin concentrations can be made by either visual comparison with standard solutions or spectrophotometric comparisons (at 650 nm) to knowns. Overall correlation was good between ELISA and thin-layer chromatographic results for corn and roasted peanut products, with 93 and 98% correct responses for visual and instrumental determinations, respectively. For instrumental determinations of aflatoxin in corn and roasted peanuts in the less than or equal to 20 ng/g range, the relative standard deviations for repeatability (RSDr) were 14.9 and 41.4%, respectively, and the relative standard deviations for reproducibility (RSDR) were 45.7 and 43.5%, respectively. For instrumental determination of greater than 20 ng/g, the respective RSDr and RSDR values were 19.4 and 52.7% for corn and 23.3 and 23.3% for roasted peanuts.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal - Association of Official Analytical Chemists AU - Park, D L AU - Miller, B M AU - Nesheim, S AU - Trucksess, M W AU - Vekich, A AU - Bidigare, B AU - McVey, J L AU - Brown, L H AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 638 EP - 643 VL - 72 IS - 4 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Indicators and Reagents KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Food Contamination KW - Enzyme-Linked Immunosorbent Assay KW - Chromatography, Thin Layer KW - Aflatoxins -- analysis KW - Arachis -- analysis KW - Zea mays -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79131260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Visual+and+semiquantitative+spectrophotometric+ELISA+screening+method+for+aflatoxin+B1+in+corn+and+peanut+products%3A+follow-up+collaborative+study.&rft.au=Park%2C+D+L%3BMiller%2C+B+M%3BNesheim%2C+S%3BTrucksess%2C+M+W%3BVekich%2C+A%3BBidigare%2C+B%3BMcVey%2C+J+L%3BBrown%2C+L+H&rft.aulast=Park&rft.aufirst=D&rft.date=1989-07-01&rft.volume=72&rft.issue=4&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aflatoxins in domestic and imported foods and feeds. AN - 79131124; 2759983 AB - Aflatoxins, metabolic products of the molds Aspergillus flavus and A. parasiticus, may occur in foods and feeds. These toxins cannot be entirely avoided or eliminated from foods or feeds by current agronomic and manufacturing processes and are considered unavoidable contaminants. To limit aflatoxin exposure, the U.S. Food and Drug Administration (FDA) has set action levels for these toxins in foods and feeds involved in interstate commerce. FDA continually monitors food and feed industries through compliance programs. This report summarizes data generated from compliance programs on aflatoxins for the fiscal year 1986. Commodities sampled included peanuts and peanut products, corn and corn products, tree nuts, cottonseed, milk, spices, manufactured products, and miscellaneous foods and feeds. Correlations were highest between aflatoxin contamination and geographical areas for corn/corn products and cottonseed/cottonseed meal. Higher incidences of aflatoxin contamination in corn and corn products designated for human consumption were observed in samples collected in the southeastern states (32 and 28%, respectively). A higher incidence of contamination was observed in corn designated for animal feed from Arkansas-Texas (74%) than from the southeastern states (47%). Only 3% of feed corn from corn belt states contained detectable aflatoxins. All aflatoxin-contaminated cottonseed was collected in the Arizona-California area; 80% of cottonseed meal analyzed from this area also contained detectable levels of aflatoxins.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal - Association of Official Analytical Chemists AU - Wood, G E AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 543 EP - 548 VL - 72 IS - 4 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Cottonseed Oil KW - Index Medicus KW - United States KW - Seeds -- analysis KW - Cottonseed Oil -- analysis KW - Nuts -- analysis KW - Arachis -- analysis KW - Condiments -- analysis KW - Zea mays -- analysis KW - Aflatoxins -- analysis KW - Food Contamination -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79131124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Aflatoxins+in+domestic+and+imported+foods+and+feeds.&rft.au=Wood%2C+G+E&rft.aulast=Wood&rft.aufirst=G&rft.date=1989-07-01&rft.volume=72&rft.issue=4&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Establishing aerosol exposure concentrations for inhalation toxicity studies. AN - 79090386; 2749728 AB - Criteria for the selection of aerosol concentrations to be used in inhalation studies assessing the toxicity and carcinogenicity of chemical substances were discussed by the authors in a meeting sponsored by the National Toxicology Program. Concepts in the design of aerosol inhalation studies emerged from that meeting and are being communicated through this publication. Inhalation studies assessing the toxicity and carcinogenicity of aerosols have often used maximum exposure levels on the basis of technological feasibility. Evidence has now accumulated that the amount of pulmonary burden of deposited particles impacts on particle clearance above some as yet not well-defined exposure concentration. The sequelae are such that lung clearance decreases with increased particulate burden to the point of approaching complete cessation. This paper focuses on the major determinants in establishing maximal aerosol concentrations for use in inhalation toxicity studies with special emphasis on experimental design features to assess lung retention. The subject matter of this paper is a rapidly developing area in terms of knowledge. Accordingly, the contents of this article are intended as guidelines and not as absolute rules for the conduct and interpretation of inhalation exposure studies. JF - Toxicology and applied pharmacology AU - Lewis, T R AU - Morrow, P E AU - McClellan, R O AU - Raabe, O G AU - Kennedy, G L AU - Schwetz, B A AU - Goehl, T J AU - Roycroft, J H AU - Chhabra, R S AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 452276. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 377 EP - 383 VL - 99 IS - 3 SN - 0041-008X, 0041-008X KW - Aerosols KW - 0 KW - Dust KW - Index Medicus KW - Animals KW - Body Burden KW - Administration, Inhalation KW - Lung -- drug effects KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79090386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Establishing+aerosol+exposure+concentrations+for+inhalation+toxicity+studies.&rft.au=Lewis%2C+T+R%3BMorrow%2C+P+E%3BMcClellan%2C+R+O%3BRaabe%2C+O+G%3BKennedy%2C+G+L%3BSchwetz%2C+B+A%3BGoehl%2C+T+J%3BRoycroft%2C+J+H%3BChhabra%2C+R+S&rft.aulast=Lewis&rft.aufirst=T&rft.date=1989-07-01&rft.volume=99&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-18 N1 - Date created - 1989-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical pharmacokinetics of zidovudine. An overview of current data. AN - 79071427; 2663302 JF - Clinical pharmacokinetics AU - Collins, J M AU - Unadkat, J D AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 1 EP - 9 VL - 17 IS - 1 SN - 0312-5963, 0312-5963 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - AIDS/HIV KW - Maternal-Fetal Exchange KW - HIV -- drug effects KW - Drug Interactions KW - Half-Life KW - Humans KW - Semen -- metabolism KW - Protein Binding KW - Female KW - Pregnancy KW - Zidovudine -- pharmacokinetics KW - Zidovudine -- urine KW - Zidovudine -- blood KW - Zidovudine -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79071427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacokinetics&rft.atitle=Clinical+pharmacokinetics+of+zidovudine.+An+overview+of+current+data.&rft.au=Collins%2C+J+M%3BUnadkat%2C+J+D&rft.aulast=Collins&rft.aufirst=J&rft.date=1989-07-01&rft.volume=17&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacokinetics&rft.issn=03125963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-14 N1 - Date created - 1989-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A Suicide Epidemic in an American Indian Community AN - 61223385; 91X5151 AB - An analysis of the 9 reported suicides, 3 possible suicides, & 88 suicide attempts or threats that occurred Aug-Sept 1985 on the Wind River Indian Reservation (Mont). Statistics compiled by the Behavior Health Program (BHP) on the reservation suggest that youth, drug & alcohol abuse, high unemployment, negative attitudes toward American Indians, & loss of tribal ceremonies & traditions are related to suicide. The responses of the BHP, parents, tribal leaders, alcohol & community health programs, & Indian organizations are described, & the impact of the media is criticized. A three-stage model for suicide intervention is presented, & a long-term prevention program outlined. Larger implications for the serious national problem of suicide among American Indians & Alaska natives are discussed, & community-level actions are recommended. 1 Table, 1 Figure, 5 References. S. Dilts JF - American Indian and Alaska Native Mental Health Research AU - Tower, Margene AD - Billings Area Indian Health Service, 711 Central Ave MT 59102 Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 34 EP - 44 VL - 3 IS - 1 SN - 0893-5394, 0893-5394 KW - suicide epidemic, Wind River Indian Reservation, Montana KW - statistics, other data KW - 1985 KW - American Indian Reservations KW - Suicide KW - Traditional Societies KW - American Indians KW - Montana KW - article KW - 1939: the family and socialization; adolescence & youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61223385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Indian+and+Alaska+Native+Mental+Health+Research&rft.atitle=A+Suicide+Epidemic+in+an+American+Indian+Community&rft.au=Tower%2C+Margene&rft.aulast=Tower&rft.aufirst=Margene&rft.date=1989-07-01&rft.volume=3&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=American+Indian+and+Alaska+Native+Mental+Health+Research&rft.issn=08935394&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AIAREB N1 - SubjectsTermNotLitGenreText - Traditional Societies; American Indians; Suicide; Montana; American Indian Reservations ER - TY - JOUR T1 - Bovine Blood Lead Reference Material AN - 1093454430; 17185100 AB - A protocol is described for the preparation and characterization of bovine blood lead (Pb) reference material (RM). Adult bovine animals are orally dosed with Pb as Pb(NO3)2, and blood is collected directly from the jugular vein into 5-mL evacuated, low-Pb glass tubes containing EDTA as anticoagulant. The blood is cooled to 4A?C for 24 h and frozen and stored at a degree 20A?C. Over 400 RMs were prepared and certified for reference values (RV) since the inception in 1974 of the Childhood Blood Lead Proficiency Testing Program. Five reference laboratories employing blood Pb methods of various principles were used to certify the RV, representing the true value, of 5 representative RMs containing 6.4a-'54.0 A Delta *mgPb/mL. Intertube homogeneity was verified by reference laboratories determining blood Pb in 20 tubes of 150 tubes collected from each of the 5 representative RMs. Intratube homogeneity was verified by an internal laboratory determining Pb in 12 consecutive 10-A Delta *mL samples from 5 mL of blood in each of 3 representative RMs. Pb was unchanged in 37 bovine blood Pb RMs containing EDTA as anticoagulant after storage at a degree 20A?C for 32a-'48 months. JF - Journal of Analytical Toxicology AU - Cox, Dennis H AU - Duncan, Carolyn E AU - Wyatt, Gloria P AU - Meadow, Janie S AU - Robinson, John B AD - Centers for Disease Control, Public Health Service, Department of Health and Human Services, Atlanta, GA 30333 Y1 - 1989/07// PY - 1989 DA - Jul 1989 SP - 204 EP - 207 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 13 IS - 4 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Anticoagulants KW - Blood KW - Children KW - Edetic acid KW - Jugular vein KW - Lead KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093454430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Bovine+Blood+Lead+Reference+Material&rft.au=Cox%2C+Dennis+H%3BDuncan%2C+Carolyn+E%3BWyatt%2C+Gloria+P%3BMeadow%2C+Janie+S%3BRobinson%2C+John+B&rft.aulast=Cox&rft.aufirst=Dennis&rft.date=1989-07-01&rft.volume=13&rft.issue=4&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/1989/00000013/00000004/art00004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Blood; Anticoagulants; Jugular vein; Children; Lead; Edetic acid ER - TY - JOUR T1 - Muscarinic-stimulated norepinephrine release and phosphoinositide hydrolysis in PC12 cells are independent events. AN - 79021758; 2543676 AB - This laboratory has reported recently that muscarinic receptor-stimulated release of norepinephrine from pheochromocytoma (PC12) cells is dependent upon an influx of Ca2+ through a Ca2+ channel that is regulated by a pertussis toxin-sensitive GTP-binding protein (G-protein) (Inoue, K., and Kenimer J. G. (1988) J. Biol. Chem. 263, 8157-8161). In the present study, we have examined the role of phosphoinositide hydrolysis in this mechanism. The muscarinic agonist methacholine was shown to stimulate phosphoinositide hydrolysis by a mechanism that was sensitive to pertussis toxin inhibition. When assayed in the absence of Ca2+, muscarinic-stimulated norepinephrine release but not phosphoinositide hydrolysis was blocked. Conversely, muscarinic-stimulated phosphoinositide hydrolysis but not norepinephrine release was blocked in cells preincubated with phorbol 12,13-dibutyrate. In contrast to several previous hypotheses that suggested that muscarinic-stimulated neurotransmitter release is dependent upon phosphoinositide hydrolysis, our results suggest that these two muscarinic-stimulated processes are independent events in PC12 cells. Inhibition studies with muscarinic receptor subtype-specific antagonists suggest that norepinephrine release is regulated by an M2 subtype muscarinic receptor and that phosphoinositide hydrolysis is regulated by an M3 subtype muscarinic receptor. JF - The Journal of biological chemistry AU - Takashima, A AU - Kenimer, J G AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1989/06/25/ PY - 1989 DA - 1989 Jun 25 SP - 10654 EP - 10659 VL - 264 IS - 18 SN - 0021-9258, 0021-9258 KW - Diamines KW - 0 KW - Methacholine Compounds KW - Parasympathomimetics KW - Phosphatidylinositols KW - Receptors, Muscarinic KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Pirenzepine KW - 3G0285N20N KW - Atropine KW - 7C0697DR9I KW - methoctramine KW - RLO2T99XT3 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats KW - Animals KW - Pirenzepine -- pharmacology KW - Adrenal Gland Neoplasms KW - Kinetics KW - Diamines -- pharmacology KW - Atropine -- pharmacology KW - Hydrolysis KW - Pheochromocytoma KW - Cell Line KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Phosphatidylinositols -- metabolism KW - Parasympathomimetics -- pharmacology KW - Methacholine Compounds -- pharmacology KW - Receptors, Muscarinic -- drug effects KW - Norepinephrine -- secretion KW - Receptors, Muscarinic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79021758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Muscarinic-stimulated+norepinephrine+release+and+phosphoinositide+hydrolysis+in+PC12+cells+are+independent+events.&rft.au=Takashima%2C+A%3BKenimer%2C+J+G&rft.aulast=Takashima&rft.aufirst=A&rft.date=1989-06-25&rft.volume=264&rft.issue=18&rft.spage=10654&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-18 N1 - Date created - 1989-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Computer readable data from NIOSH. AN - 79554611; 2534923 JF - Seminars in dermatology AU - Murthy, L I AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 70 EP - 71 VL - 8 IS - 2 SN - 0278-145X, 0278-145X KW - Index Medicus KW - United States KW - Humans KW - Environmental Exposure KW - National Institute for Occupational Safety and Health (U.S.) KW - Dermatitis, Contact KW - Information Systems KW - Dermatitis, Occupational -- etiology KW - Bibliography as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79554611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+dermatology&rft.atitle=Computer+readable+data+from+NIOSH.&rft.au=Murthy%2C+L+I&rft.aulast=Murthy&rft.aufirst=L&rft.date=1989-06-01&rft.volume=8&rft.issue=2&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Seminars+in+dermatology&rft.issn=0278145X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-11 N1 - Date created - 1990-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification and enumeration of virulent Listeria strains. AN - 79551793; 2518383 AB - Recent outbreaks and a continuous increase in cases of listeriosis underscore the need for rapid, sensitive and reliable techniques to detect Listeria. Of the species of Listeria, only L. monocytogenes has been found to be associated with human infections. One factor which definitely contributes to its pathogenicity is the presence of hemolysins, although L. ivanovii and L. seeligeri also elaborate hemolysins. Based upon cloned hemolysin genes, we have developed DNA probes specifically for detecting L. monocytogenes. The technique combines growth of bacterial colonies on selective agar plates and DNA hybridization of these colonies on a solid matrix. This technique permits identification and enumeration, and the entire procedure can be completed in 3-4 days. Our method was found to be suitable for identifying and enumerating this organism in various foods, the main vehicle of human infection. Advantages and disadvantages of this technique are discussed and compared with other existing techniques. JF - International journal of food microbiology AU - Datta, A R AU - Wentz, B A AD - Division of Microbiology, CFSAN, Food and Drug Administration, Washington 20204. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 259 EP - 264 VL - 8 IS - 3 SN - 0168-1605, 0168-1605 KW - DNA Probes KW - 0 KW - Index Medicus KW - Virulence KW - Listeria monocytogenes -- pathogenicity KW - Listeria monocytogenes -- isolation & purification KW - Listeria monocytogenes -- genetics KW - Listeria monocytogenes -- growth & development KW - Colony Count, Microbial KW - Nucleic Acid Hybridization KW - Food Microbiology KW - Listeria -- genetics KW - Listeria -- growth & development KW - Listeria -- isolation & purification KW - Listeria -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79551793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Identification+and+enumeration+of+virulent+Listeria+strains.&rft.au=Datta%2C+A+R%3BWentz%2C+B+A&rft.aulast=Datta&rft.aufirst=A&rft.date=1989-06-01&rft.volume=8&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-26 N1 - Date created - 1990-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Semen quality in workers exposed to 2-ethoxyethanol. AN - 79332859; 2818974 AB - To evaluate whether long term exposure to 2-ethoxyethanol (2EE) may affect semen quality, a cross sectional study was conducted among men exposed to 2EE used as a binder slurry in a metal castings process. Full shift breathing zone exposures to 2EE ranged from non-detectable to 24 ppm (geometric mean 6.6 ppm). Because of the potential for substantial absorption of 2EE through skin exposure, urine measurements of the metabolite of 2EE, 2-ethoxyacetic acid (2EAA) were conducted, showing levels of 2EAA ranging from non-detectable to 163 mg 2EAA/g creatinine. Only 37 exposed men (50% participation) and 39 non-exposed comparison (26% participation) from elsewhere in the plant provided a sperm sample. A questionnaire to determine personal habits, and medical and work histories, and a physical examination of the urogenital tract were also administered. The average sperm count per ejaculate among the workers exposed to 2EE was significantly lower than that of the unexposed group (113 v 154 million sperm per ejaculate respectively; p = 0.05) after consideration of abstinence, sample age, subjects' age, tobacco, alcohol and caffeine use, urogenital disorders, fever, and other illnesses. The mean sperm concentrations of the exposed and unexposed groups did not significantly differ from each other (44 and 53 million/ml respectively). No effect of exposure to 2EE on semen volume, sperm viability, motility, velocity, and normal morphology or testicular volume was detected, although some differences in the proportion of abnormal sperm shapes were observed. These data suggest that there may be an effect of 2EE on sperm count among these workers, although the possibility that other factors may be affecting the semen quality in both exposed and unexposed men in this population or that the results reflect bias introduced by the low participation rates cannot be excluded. JF - British journal of industrial medicine AU - Ratcliffe, J M AU - Schrader, S M AU - Clapp, D E AU - Halperin, W E AU - Turner, T W AU - Hornung, R W AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 399 EP - 406 VL - 46 IS - 6 SN - 0007-1072, 0007-1072 KW - Acetates KW - 0 KW - Ethylene Glycols KW - ethoxyacetic acid KW - 467VW095BX KW - 2-ethoxyethanol KW - IDK7C2HS09 KW - Index Medicus KW - Cross-Sectional Studies KW - Sperm Count KW - Humans KW - Adult KW - Oligospermia -- chemically induced KW - Acetates -- urine KW - Sperm Motility -- drug effects KW - Male KW - Ethylene Glycols -- adverse effects KW - Occupational Diseases -- chemically induced KW - Semen -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79332859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+industrial+medicine&rft.atitle=Semen+quality+in+workers+exposed+to+2-ethoxyethanol.&rft.au=Ratcliffe%2C+J+M%3BSchrader%2C+S+M%3BClapp%2C+D+E%3BHalperin%2C+W+E%3BTurner%2C+T+W%3BHornung%2C+R+W&rft.aulast=Ratcliffe&rft.aufirst=J&rft.date=1989-06-01&rft.volume=46&rft.issue=6&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=British+journal+of+industrial+medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-27 N1 - Date created - 1989-12-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fertil Steril. 1971 Feb;22(2):134-7 [5544373] J Occup Med. 1987 Dec;29(12):963-6 [3323429] J Urol. 1978 Dec;120(6):691-4 [731807] Sangyo Igaku. 1979 Jan;21(1):29-35 [470211] J Reprod Fertil. 1979 Nov;57(2):391-5 [513028] Fertil Steril. 1981 Mar;35(3):325-7 [7202758] Fertil Steril. 1982 Dec;38(6):756-9 [7141019] Toxicol Appl Pharmacol. 1983 Jul;69(3):385-99 [6879608] J Reprod Fertil. 1984 Jan;70(1):219-28 [6694140] J Toxicol Environ Health. 1984;13(4-6):763-75 [6492198] Environ Health Perspect. 1984 Aug;57:157-63 [6499800] Environ Health Perspect. 1984 Aug;57:249-53 [6499809] Environ Health Perspect. 1984 Aug;57:85-90 [6499823] Environ Health Perspect. 1984 Aug;57:97-103 [6541999] Int J Androl. 1984 Oct;7(5):369-82 [6441782] Br J Ind Med. 1987 May;44(5):317-26 [3297130] Environ Mol Mutagen. 1987;10 Suppl 10:1-175 [3319609] Arzneimittelforschung. 1971 Jun;21(6):880-5 [5109283] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative recovery of uninjured and heat-injured Listeria monocytogenes cells from bovine milk. AN - 79157601; 2504109 AB - The standard selective enrichment protocols of the Food and Drug Administration (FDA) and U.S. Department of Agriculture (USDA) were compared with an experimental nonselective broth enrichment (NSB) protocol and variations of the standard cold-enrichment (CE) protocol for the recovery of heat-injured Listeria monocytogenes. Bacterial cells (10(7)/ml) were suspended in sterile milk and heated at 71.7 degrees C in a slug-flow heat exchanger for holding times ranging from 1 to 30 s. Surviving cells were determined (50% endpoint) by the given protocols, and the following D values were obtained: NSB, D = 2.0 +/- 0.5 s; FDA, D = 1.4 +/- 0.3 s; USDA, D = 0.6 +/- 0.2 s; CE, D less than or equal to 1.2 s. The respective direct-plating media used in these enrichments were also analyzed for recovery, and the following D values were calculated from the enumeration of surviving cells; NSB, D = 2.7 +/- 0.8 s; FDA, D = 1.3 +/- 0.4 s; USDA, D = 0.7 +/- 0.2 s. The low levels of heat-injured L. monocytogenes cells which were detected at inactivation endpoints on the optimal nonselective media (25 degrees C for 7 days) failed to recover and multiply during experimental CEs (4 degrees C for 28 days). Initial inactivation experiments in which raw whole milk was used as the heating menstruum gave much lower recoveries with all protocols. The detectable limits for uninjured cells that were suspended in raw milk were similar (0.35 to 3.2 cells per ml) for the standard CE, FDA, and USDA protocols.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Applied and environmental microbiology AU - Crawford, R G AU - Beliveau, C M AU - Peeler, J T AU - Donnelly, C W AU - Bunning, V K AD - Division of Microbiology, Food and Drug Administration, Cincinnati, Ohio 45226. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 1490 EP - 1494 VL - 55 IS - 6 SN - 0099-2240, 0099-2240 KW - Culture Media KW - 0 KW - Index Medicus KW - Hot Temperature KW - Animals KW - Cattle KW - Food Contamination KW - Sterilization KW - Listeria monocytogenes -- isolation & purification KW - Food Microbiology KW - Milk -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79157601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Comparative+recovery+of+uninjured+and+heat-injured+Listeria+monocytogenes+cells+from+bovine+milk.&rft.au=Crawford%2C+R+G%3BBeliveau%2C+C+M%3BPeeler%2C+J+T%3BDonnelly%2C+C+W%3BBunning%2C+V+K&rft.aulast=Crawford&rft.aufirst=R&rft.date=1989-06-01&rft.volume=55&rft.issue=6&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-21 N1 - Date created - 1989-09-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Microbiol. 1969 Nov;18(5):889-92 [5395711] Appl Microbiol. 1956 Jul;4(4):211-21 [13355404] Zentralbl Bakteriol A. 1980;246(4):506-11 [6775446] N Engl J Med. 1985 Feb 14;312(7):404-7 [3918263] Can J Microbiol. 1985 Oct;31(10):938-41 [4063881] Appl Environ Microbiol. 1986 Feb;51(2):438-40 [3082282] Appl Environ Microbiol. 1986 Oct;52(4):689-95 [3096202] Appl Environ Microbiol. 1986 Nov;52(5):1215-7 [3024563] Appl Environ Microbiol. 1986 Dec;52(6):1398-402 [3098172] Can J Microbiol. 1986 Oct;32(10):791-5 [3098397] J Appl Bacteriol. 1987 Aug;63(2):99-116 [3308806] Appl Environ Microbiol. 1987 Jul;53(7):1433-8 [3116926] Appl Environ Microbiol. 1988 Jan;54(1):165-7 [3345076] J Appl Bacteriol. 1987 Dec;63(6):533-7 [3126174] Appl Environ Microbiol. 1988 Feb;54(2):364-70 [3128163] J Assoc Off Anal Chem. 1988 May-Jun;71(3):644-6 [3134334] J Assoc Off Anal Chem. 1988 May-Jun;71(3):651-4 [3134336] J Assoc Off Anal Chem. 1988 May-Jun;71(3):658-60 [3134338] J Assoc Off Anal Chem. 1988 May-Jun;71(3):660-4 [3134339] Can J Microbiol. 1988 Feb;34(2):95-100 [3135930] Appl Environ Microbiol. 1988 Jun;54(6):1451-6 [3137864] Zentralbl Bakteriol Orig. 1971;216(1):88-91 [4994622] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transgenic mice as future tools in risk assessment. AN - 79157493; 2669041 AB - Historically, mice have served a routine and useful purpose in the research, development, and testing of biologicals, chemicals, and drugs for efficacy, toxicity, and carcinogenic risk. The literature is replete with examples using mice to study organic compounds both in short-term tests involving tumor initiation and promotion and in long-term experiments dealing with fertility, reproduction, and teratology. During the past two decades, a virtual explosion of advances has occurred in modern biology that includes the discoveries of retroviruses, oncogenes, DNA restriction enzymes, nucleotide sequence analyses, and microinjection techniques. Fusion of these milestones in genetic, molecular, and cell biology with recent developments in mouse embryology has opened novel avenues and methods of experimentation as significant additions to the risk assessment armamentarium that currently uses both prokaryotes and eukaryotes. Some promising directions afforded by transgenic mice as powerful future tools in risk assessment will be summarized below. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Cordaro, J C AD - Division of Research and Testing, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 157 EP - 168 VL - 9 IS - 2 SN - 0272-4332, 0272-4332 KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Oncogenes KW - Carcinogenicity Tests KW - Mice KW - HIV KW - Mutation KW - Translocation, Genetic KW - Risk KW - Mice, Transgenic -- microbiology KW - Mice, Transgenic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79157493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Transgenic+mice+as+future+tools+in+risk+assessment.&rft.au=Cordaro%2C+J+C&rft.aulast=Cordaro&rft.aufirst=J&rft.date=1989-06-01&rft.volume=9&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-18 N1 - Date created - 1989-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Critical assessment of carcinogenic risk policy. AN - 79126662; 2756168 AB - Fact. Cancer is a relatively common yet greatly feared disease. Belief. The concept that cancer is largely preventable is widely held by advocate groups, the press, and Congress. Belief. The concept that carcinogens at any level of exposure pose a significant cancer risk to human is widely believed by the public. Fact. In contrast to this belief, carcinogens are now known to be widespread in the environment and that virtually all substances are contaminated with carcinogens at some albiet low level. Fact. The solution to the ubiguitous presence of carcinogens cannot be solved by regulatory fiat. Fact. Often the only viable solution to regulating carcinogens is setting maximum levels of acceptable exposure (tolerances). Belief. In U.S. society, the process of establishing tolerances must be conducted in the open, providing adequate opportunity for public comment. Fact. The courts will sustain regulatory agency decisions about risks only if the administrative procedures used comply with the Administrative Procedures Act and if the technical methodology used is in good standing. Fact. For the method to be in good standing it cannot be a recent invention created after the fact to solve the issue at hand but must instead be a procedure that is claimed to be generally applicable to determining or estimating cancer risk. Belief. QRA should be an orderly procedure or process by which cancer risk estimations are conducted in an unbiased manner. As such it is fundamentally acceptable to the courts for resolving disputes. Fact. However, because QRA is dependent upon a large number of assumptions and because regulatory agencies feel compelled to act in a conservative, risk-adverse manner, risk estimates are often criticized for being over stated. Belief. To make risk estimates more realistic, data or facts must substitute for worst case assumptions. Fact. This process of substituting scientific facts for assumptions is occurring but it is expensive, time consuming, and not always possible. Nevertheless, it constitutes a major opportunity for improving the process by which risk estimates are made. JF - Regulatory toxicology and pharmacology : RTP AU - Flamm, W G AD - Office of Toxicological Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 216 EP - 224 VL - 9 IS - 3 SN - 0273-2300, 0273-2300 KW - Carcinogens, Environmental KW - 0 KW - Pesticide Residues KW - Index Medicus KW - United States KW - Risk KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Safety KW - Toxicology -- methods KW - Drug Residues KW - Science KW - Models, Biological KW - Legislation, Food KW - Neoplasms -- prevention & control KW - Health Policy KW - Carcinogens, Environmental -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79126662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Critical+assessment+of+carcinogenic+risk+policy.&rft.au=Flamm%2C+W+G&rft.aulast=Flamm&rft.aufirst=W&rft.date=1989-06-01&rft.volume=9&rft.issue=3&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The risk of risk assessment. AN - 79122858; 2756172 JF - Regulatory toxicology and pharmacology : RTP AU - Houk, V N AD - Center for Environmental Health and Injury Control, U.S. Department of Health and Human Services, Atlanta, Georgia 30333. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 257 EP - 262 VL - 9 IS - 3 SN - 0273-2300, 0273-2300 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Animals KW - Epidemiologic Methods KW - Humans KW - Toxicology -- methods KW - Research Design -- standards KW - Predictive Value of Tests KW - Hazardous Substances -- toxicity KW - Risk UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79122858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+risk+of+risk+assessment.&rft.au=Houk%2C+V+N&rft.aulast=Houk&rft.aufirst=V&rft.date=1989-06-01&rft.volume=9&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The health effects of oral contraceptives: misperceptions, controversies, and continuing good news. AN - 79094147; 2663276 JF - Clinical obstetrics and gynecology AU - Peterson, H B AU - Lee, N C AD - Center for Health Promotion and Education, US Department of Health and Human Services, Atlanta, Georgia. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 339 EP - 355 VL - 32 IS - 2 SN - 0009-9201, 0009-9201 KW - Contraceptives, Oral KW - 0 KW - Index Medicus KW - Population KW - United States KW - Pregnancy Complications KW - Communication KW - Breast Cancer KW - Endometrial Cancer KW - Pelvic Infections KW - Developed Countries KW - Thromboembolism KW - Toxic Shock Syndrome KW - Liver Neoplasms KW - Misinformation KW - Ovarian Cancer KW - Diseases KW - Literature Review KW - Family Planning KW - Infections KW - Neoplasms, Benign KW - North America KW - Contraceptive Methods--beneficial effects KW - Americas KW - Pregnancy, Ectopic KW - Cervical Cancer KW - Vascular Diseases KW - Oral Contraceptives--beneficial effects KW - Cancer KW - Fibroids KW - Northern America KW - Neoplasms KW - Contraception KW - Embolism KW - Risk Factors KW - Biology KW - Humans KW - Adult KW - Adolescent KW - Female KW - Contraceptives, Oral -- adverse effects KW - Contraceptives, Oral -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79094147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+obstetrics+and+gynecology&rft.atitle=The+health+effects+of+oral+contraceptives%3A+misperceptions%2C+controversies%2C+and+continuing+good+news.&rft.au=Peterson%2C+H+B%3BLee%2C+N+C&rft.aulast=Peterson&rft.aufirst=H&rft.date=1989-06-01&rft.volume=32&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Clinical+obstetrics+and+gynecology&rft.issn=00099201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Poisonous plant information system (PPIS). AN - 79049796; 2741312 AB - There is a need for efficient storage and retrieval of information about poisonous plants. The purpose of this article is to describe the Poisonous Plant Information System (PPIS) and to discuss basic issues in building and maintaining databases within the larger context of combined veterinary databases. This paper defines the database of PPIS and discusses its contents. Access methods are explained and sample search techniques are given. JF - Veterinary and human toxicology AU - Wagstaff, D J AU - Raisbeck, M AU - Wagstaff, A T AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 237 EP - 238 VL - 31 IS - 3 SN - 0145-6296, 0145-6296 KW - Index Medicus KW - Plants, Toxic KW - Information Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79049796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Poisonous+plant+information+system+%28PPIS%29.&rft.au=Wagstaff%2C+D+J%3BRaisbeck%2C+M%3BWagstaff%2C+A+T&rft.aulast=Wagstaff&rft.aufirst=D&rft.date=1989-06-01&rft.volume=31&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancing effect of tetrandrine on sister-chromatid exchanges induced by mitomycin C and cigarette-smoke condensate in mammalian cells. AN - 79036883; 2499785 AB - The enhancing effect of tetrandrine, an antisilicosis, antitumor and antiinflammatory drug, on the genotoxic activity of two known mutagens, mitomycin C (MMC) and cigarette-smoke condensate (CSC), has been studied using cultured Chinese hamster lung (V79) cells. The sister-chromatid exchange (SCE) was used as genetic endpoint to measure genotoxicity. One-day cultured cells were exposed to the test chemicals for 3 h with or without metabolic activation. The results show that the frequencies of SCE induced by MMC or CSC were enhanced by tetrandrine. The percent of enhancement was dependent on the concentration of tetrandrine. JF - Mutation research AU - Xing, S G AU - Wu, Z L AU - Whong, W Z AU - Ong, T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 99 EP - 102 VL - 226 IS - 2 SN - 0027-5107, 0027-5107 KW - Alkaloids KW - 0 KW - Benzylisoquinolines KW - Mitomycins KW - Smoke KW - tetrandrine KW - 29EX23D5AJ KW - Mitomycin KW - 50SG953SK6 KW - Index Medicus KW - Plants, Toxic KW - Animals KW - Mutagenicity Tests KW - Biotransformation KW - In Vitro Techniques KW - Tobacco KW - Drug Synergism KW - Cell Line KW - Cricetinae KW - Mitomycins -- toxicity KW - Sister Chromatid Exchange -- drug effects KW - Alkaloids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79036883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Enhancing+effect+of+tetrandrine+on+sister-chromatid+exchanges+induced+by+mitomycin+C+and+cigarette-smoke+condensate+in+mammalian+cells.&rft.au=Xing%2C+S+G%3BWu%2C+Z+L%3BWhong%2C+W+Z%3BOng%2C+T&rft.aulast=Xing&rft.aufirst=S&rft.date=1989-06-01&rft.volume=226&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-20 N1 - Date created - 1989-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Physiological and subjective responses to working in disposable protective coveralls and respirators commonly used by the asbestos abatement industry. AN - 79031681; 2735315 AB - The physiological and subjective effects of working with different respirators while wearing lightweight disposable (Tyvek 1412 polyolefin) coveralls commonly used by the asbestos abatement industry were studied. Nine healthy men (mean age = 27.3 yr, weight = 76.9 kg) each performed a series of four exercise tests with four different respirator ensembles in counterbalanced order. Treadmill work was performed at a set walking speed of 4 kph (2.5 mph), 0 percent elevation (220 kcal/hr), a controlled environmental temperature of 33.9 degrees C, and 50% relative humidity. Each test continued up to 120 min, with repeated work/rest intervals of 26 min of work and 4 min of rest. Tyvek disposable coveralls and hoods were worn with each of these four different respirator ensembles: (1) control--a lightweight, low resistance mask; (2) HEPA--an air purifying, full facepiece respirator with dual high efficiency filters; (3) SAR--a supplied-air, pressure-demand respirator with escape filter; (4) SCBA--an open circuit, pressure-demand, self-contained breathing apparatus. Physiological measurements obtained every minute during each test included heart rate and skin and rectal temperatures. Subjective evaluations of clothing, respirator, and facepiece comfort, ease of breathing, temperature and perspiration in the mask and clothing, and respirator load also were measured at the end of the test. Data were analyzed using an analysis of variance. Results indicated that heart rate at the end of the test differed by less than 8 BPM between the control condition and the SCBA (heaviest) condition.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American Industrial Hygiene Association journal AU - White, M K AU - Hodous, T K AU - Hudnall, J B AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV 26505-2888. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 313 EP - 319 VL - 50 IS - 6 SN - 0002-8894, 0002-8894 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Space life sciences KW - Respiratory Function Tests KW - Body Weight KW - Reference Values KW - Heart Rate KW - Body Temperature KW - Sweating KW - Humans KW - Adult KW - Male KW - Hot Temperature KW - Respiratory Protective Devices KW - Protective Clothing KW - Respiration KW - Physical Exertion KW - Protective Devices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79031681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Physiological+and+subjective+responses+to+working+in+disposable+protective+coveralls+and+respirators+commonly+used+by+the+asbestos+abatement+industry.&rft.au=White%2C+M+K%3BHodous%2C+T+K%3BHudnall%2C+J+B&rft.aulast=White&rft.aufirst=M&rft.date=1989-06-01&rft.volume=50&rft.issue=6&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-24 N1 - Date created - 1989-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gonadotropin-dependent metabolism of 7,12-dimethylbenz(a)anthracene in the ovary of rhesus monkey. AN - 79027879; 2500126 JF - Biochemical pharmacology AU - Bengtsson, M AU - Mattison, D R AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/06/01/ PY - 1989 DA - 1989 Jun 01 SP - 1869 EP - 1872 VL - 38 IS - 11 SN - 0006-2952, 0006-2952 KW - Gonadotropins, Equine KW - 0 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Index Medicus KW - Animals KW - Mixed Function Oxygenases -- metabolism KW - Cells, Cultured KW - In Vitro Techniques KW - Cytochrome P-450 Enzyme System -- metabolism KW - Macaca mulatta KW - Cell Separation KW - Female KW - Biotransformation -- drug effects KW - Ovary -- metabolism KW - Gonadotropins, Equine -- pharmacology KW - 9,10-Dimethyl-1,2-benzanthracene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79027879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Gonadotropin-dependent+metabolism+of+7%2C12-dimethylbenz%28a%29anthracene+in+the+ovary+of+rhesus+monkey.&rft.au=Bengtsson%2C+M%3BMattison%2C+D+R&rft.aulast=Bengtsson&rft.aufirst=M&rft.date=1989-06-01&rft.volume=38&rft.issue=11&rft.spage=1869&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-20 N1 - Date created - 1989-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes. AN - 78952939; 2720650 AB - It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene or trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene as critical intermediates. Since the lung is a known target tissue for the carcinogenic action of polycyclic nitroaromatic hydrocarbons, we investigated the metabolism and DNA binding of [3H]6-nitrochrysene in 11 specimens of human bronchus. Analysis of medium from [3H]6-nitrochrysene-treated explants indicated the presence of trans-9,10-dihydroxy-9,10-dihydro-6-nitrochrysene (0.04-330 pmol/mg epithelial DNA), trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene (12-1700 pmol/mg epithelial DNA), 6-aminochrysene (1.6-2200 pmol/mg epithelial DNA), and trans-1,2-dihydroxy-1,2-dihydro-6-aminochyrsene (3.6-610 pmol/mg epithelial DNA). Both the levels and the relative proportions of these metabolites varied widely in explants from different individuals. The amount of DNA recovered and the level of DNA modification were sufficient for adduct analysis in eight of the 11 cases for which metabolite data were obtained. Five additional bronchial specimens for which metabolite data were not obtained were also analyzed for carcinogen-DNA adducts. The levels of binding varied from 0.06 to 30.5 pmol [3H]6-nitrochrysene bound/mg DNA (two adducts per 10(8) nucleotides-10 adducts per 10(6) nucleotides). HPLC analyses of enzymatic hydrolysates of the explant DNA indicated that 11 of 13 cases contained adducts with retention times identical to those of adducts derived from trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene or N-hydroxy-6-aminochrysene. The adduct derived from trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene was the major adduct detected in eight of 13 cases. The reasons for the variation in metabolism and adduct formation observed in [3H]6-nitrochrysene-treated explants of bronchus from different donors are not known but may reflect differences in the activities of enzymes responsible for the metabolism of this compound. The influence of induction of drug metabolizing enzymes on the activation pathway of 6-nitrochrysene in an intact cell system was tested using rat hepatocytes. 6-Nitrochrysene was incubated with freshly isolated hepatocytes from rats that were either untreated or pretreated with phenobarbital, 3-methylcholanthrene or Aroclor 1254. Although the levels of adducts were similar in all cases, the pattern of DNA adducts formed in these hepatocytes was dependent on the nature of the pretreatment of the rats. As previously reported, hepatocytes from untreated rats contained adducts derived from N-hydroxy-6-aminochrysene.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cancer research AU - Delclos, K B AU - el-Bayoumy, K AU - Casciano, D A AU - Walker, R P AU - Kadlubar, F F AU - Hecht, S S AU - Shivapurkar, N AU - Mandal, S AU - Stoner, G D AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/06/01/ PY - 1989 DA - 1989 Jun 01 SP - 2909 EP - 2913 VL - 49 IS - 11 SN - 0008-5472, 0008-5472 KW - Aroclors KW - 0 KW - Chrysenes KW - Phenanthrenes KW - Methylcholanthrene KW - 56-49-5 KW - 6-nitrochrysene KW - 82ZK83O33Y KW - DNA KW - 9007-49-2 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Phenobarbital -- pharmacology KW - Aroclors -- pharmacology KW - Methylcholanthrene -- pharmacology KW - Biotransformation KW - Humans KW - Male KW - Chromatography, High Pressure Liquid KW - Liver -- drug effects KW - Chrysenes -- pharmacokinetics KW - DNA -- metabolism KW - Liver -- metabolism KW - Bronchi -- metabolism KW - Bronchi -- drug effects KW - Phenanthrenes -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78952939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Metabolic+activation+of+6-nitrochrysene+in+explants+of+human+bronchus+and+in+isolated+rat+hepatocytes.&rft.au=Delclos%2C+K+B%3Bel-Bayoumy%2C+K%3BCasciano%2C+D+A%3BWalker%2C+R+P%3BKadlubar%2C+F+F%3BHecht%2C+S+S%3BShivapurkar%2C+N%3BMandal%2C+S%3BStoner%2C+G+D&rft.aulast=Delclos&rft.aufirst=K&rft.date=1989-06-01&rft.volume=49&rft.issue=11&rft.spage=2909&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. AN - 78980792; 2655175 AB - Alkyltin compounds are used as stabilizers and antifouling agents. Food chain accumulation and bioconcentration have been demonstrated in crabs, oysters and salmon exposed to tributyltin oxide. In mammalian species, tributyltin compounds may be metabolized to dibutyltin derivatives and related metabolites. Di- and tributyltins appear to be less potent neurotoxicants than trimethyltins and triethyltins. Dibutyltins and tributyltins produced bile duct damage in rats, mice and hamsters. Tributyltin oxide and dibutyltin and dioctyltin compounds are potent thymolytic and immunotoxic agents in rats. Tributyltin oxide at 5 ppm in the rat diet produced immunotoxicity in a 2-year feeding study, and at 50 ppm increased the incidence of tumors of endocrine origin. In preliminary reports, 5 ppm tributyltin produced no detectable increase in tumor incidence, and 0.5 ppm produced no detectable immunotoxicity in long-term studies. Tributyltin oxide and dibutyltin acetate did not appear to be mutagenic in a large battery of mutagenicity assays but produced base-pair substitutions in one of the bacterial strains tested. Tributyltin oxide produced mutations in Chinese hamster ovary cells, increased the incidence of micronuclei in the erythrocytes of exposed male BALB/c mice, and was highly embryotoxic in vitro. Embryotoxic and teratogenic effects in mice exposed to tributyltin oxide in vivo may have been due either to direct tributyltin oxide action or responses secondary to maternal toxicity. More information is needed to determine the applicability to human risk assessments of the immunotoxicity data derived from rat studies and to establish a definitive tolerable daily intake for tributyltin oxide. JF - Toxicology AU - Boyer, I J AD - Division of Toxicological Review and Evaluation, U.S. Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/05/15/ PY - 1989 DA - 1989 May 15 SP - 253 EP - 298 VL - 55 IS - 3 SN - 0300-483X, 0300-483X KW - Organotin Compounds KW - 0 KW - Trialkyltin Compounds KW - tributyltin KW - 4XDX163P3D KW - Index Medicus KW - Rats KW - Animals KW - Trialkyltin Compounds -- toxicity KW - Cricetulus KW - Humans KW - Mice KW - Mice, Inbred BALB C KW - Cricetinae KW - Organotin Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78980792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Toxicity+of+dibutyltin%2C+tributyltin+and+other+organotin+compounds+to+humans+and+to+experimental+animals.&rft.au=Boyer%2C+I+J&rft.aulast=Boyer&rft.aufirst=I&rft.date=1989-05-15&rft.volume=55&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-21 N1 - Date created - 1989-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity. AN - 78931067; 2785435 AB - One factor that is critical to the potential effectiveness of radioimmunotherapy is the design of radiometal-chelated antibodies that will be stable in vivo. Stability in vivo depends on the condition that both the chelate linkage and radiolabeling procedures not alter antibody specificity and biodistribution. In addition, synthesis and selection of the chelating agent is critical for each radiometal in order to prevent inappropriate release of the radiometal in vivo. In the present study, we compare the in vivo stability of seven radioimmunoconjugates that use different polyaminocarboxylate chelating agents to complex yttrium-88 to the mouse anti-human interleukin-2 receptor monoclonal antibody, anti-Tac. Chelate linkage and radiolabeling procedures did not alter the immunospecificity of anti-Tac. In order to assess whether yttrium was inappropriately released from the chelate-coupled antibody in vivo, iodine-131-labeled and yttrium-88 chelate-coupled antibodies were simultaneously administered to the same animals to correlate the decline in yttrium and radioiodinated antibody activity. The four stable yttrium-88 chelate-coupled antibodies studied displayed similar iodine-131 and yttrium-88 activity, indicating minimal elution of yttrium-88 from the complex. In contrast, the unstable yttrium-88 chelate-coupled antibodies had serum yttrium-88 activities that declined much more rapidly than their iodine-131 activities, suggesting loss of the radiolabel yttrium-88 from the chelate. Furthermore, high rates of yttrium-88 elution correlated with deposition in bone. Four chelating agents emerged as promising immunotherapeutic reagents: isothiocyanate benzyl DTPA and its derivatives 1B3M, MX, and 1M3B. All four isothiocyanate agents showed prolonged yttrium-88 vascular survival which was essentially identical to that of their iodine-131 activity with only minimum accumulation (1.4-1.8%/g) of the yttrium-88 injected dose into bone. Thus, these four chelating agents were very stable in vivo and suitable for yttrium-monoclonal antibody radioimmunotherapy. JF - Cancer research AU - Kozak, R W AU - Raubitschek, A AU - Mirzadeh, S AU - Brechbiel, M W AU - Junghans, R P AU - Gansow, O A AU - Waldmann, T A AU - Junghaus, R AD - Division of Cytokine Biology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland. Y1 - 1989/05/15/ PY - 1989 DA - 1989 May 15 SP - 2639 EP - 2644 VL - 49 IS - 10 SN - 0008-5472, 0008-5472 KW - Antibodies, Monoclonal KW - 0 KW - Chelating Agents KW - Cross-Linking Reagents KW - Immunotoxins KW - Receptors, Interleukin-2 KW - Yttrium Radioisotopes KW - Index Medicus KW - Animals KW - Immunotoxins -- therapeutic use KW - Mice KW - Tissue Distribution KW - Receptors, Interleukin-2 -- immunology KW - Female KW - Chelating Agents -- administration & dosage KW - Yttrium Radioisotopes -- administration & dosage KW - Cross-Linking Reagents -- administration & dosage KW - Neoplasms, Experimental -- therapy KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78931067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Nature+of+the+bifunctional+chelating+agent+used+for+radioimmunotherapy+with+yttrium-90+monoclonal+antibodies%3A+critical+factors+in+determining+in+vivo+survival+and+organ+toxicity.&rft.au=Kozak%2C+R+W%3BRaubitschek%2C+A%3BMirzadeh%2C+S%3BBrechbiel%2C+M+W%3BJunghans%2C+R+P%3BGansow%2C+O+A%3BWaldmann%2C+T+A%3BJunghaus%2C+R&rft.aulast=Kozak&rft.aufirst=R&rft.date=1989-05-15&rft.volume=49&rft.issue=10&rft.spage=2639&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Res 1999 Oct 15;59(20):5400 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 78953868; 2709534 JF - JAMA AU - Nightingale, S L AD - Office of Health Affairs, FDA, Rockville, MD 20857. Y1 - 1989/05/12/ PY - 1989 DA - 1989 May 12 SP - 2603 VL - 261 IS - 18 SN - 0098-7484, 0098-7484 KW - Azides KW - 0 KW - Sodium Azide KW - 968JJ8C9DV KW - Gemfibrozil KW - Q8X02027X3 KW - Abridged Index Medicus KW - Index Medicus KW - Hyperlipoproteinemia Type II -- drug therapy KW - Humans KW - Adult KW - Middle Aged KW - Drug Labeling KW - Male KW - Female KW - Radiography, Dental -- utilization KW - Gemfibrozil -- therapeutic use KW - Azides -- adverse effects KW - Renal Dialysis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78953868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Nightingale%2C+S+L&rft.aulast=Nightingale&rft.aufirst=S&rft.date=1989-05-12&rft.volume=261&rft.issue=18&rft.spage=2603&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-30 N1 - Date created - 1989-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of enzyme induction on metabolite formation of bis(2-methoxyethyl) ether in the rat. AN - 79156823; 2763314 AB - The effect of enzyme induction on the metabolism of the reproductive toxicant bis (2-methoxyethyl) ether (diglyme) was studied in male Sprague-Dawley rats. Rats were given either daily doses of diglyme at 5.1 mmol/kg body wt. by gavage or 0.1% (w/v) phenobarbital (PB) in the drinking water for 22 consecutive days. In one study, a significant reduction in the hexobarbital sleeping time was determined for rats pretreated with diglyme or PB in comparison with that determined for naive rats. In a second study, naive and pretreated rats given single oral doses of 14C-diglyme at 5.1 mmol/kg body wt. showed similar urinary 14C excretion patterns. Urinary metabolites were separated and quantified by hplc to evaluate the influence of pretreatment with either diglyme or PB on the 14C-diglyme urinary metabolite profile. The amount of (2-methoxyethoxy) acetic acid, the principal metabolite, was similar for rats given no pretreatment and for rats pretreated with either diglyme or PB. However, both pretreatments resulted in significant increases in the formation of methoxyacetic acid, a recognized reproductive toxicant. JF - Toxicology and industrial health AU - Cheever, K L AU - Richards, D E AU - Weigel, W W AU - Begley, K B AD - Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 601 EP - 607 VL - 5 IS - 3 SN - 0748-2337, 0748-2337 KW - Acetates KW - 0 KW - Ethylene Glycols KW - Methyl Ethers KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - methoxyacetic acid KW - F11T1H7Q7W KW - diglyme KW - M4BH3X0MVZ KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Phenobarbital -- pharmacology KW - Sleep -- drug effects KW - Enzyme Induction -- drug effects KW - Acetates -- biosynthesis KW - Dose-Response Relationship, Drug KW - Biotransformation KW - Cytochrome P-450 Enzyme System -- metabolism KW - Drug Synergism KW - Male KW - Methyl Ethers -- metabolism KW - Ethylene Glycols -- toxicity KW - Ethylene Glycols -- metabolism KW - Methyl Ethers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79156823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=The+role+of+enzyme+induction+on+metabolite+formation+of+bis%282-methoxyethyl%29+ether+in+the+rat.&rft.au=Cheever%2C+K+L%3BRichards%2C+D+E%3BWeigel%2C+W+W%3BBegley%2C+K+B&rft.aulast=Cheever&rft.aufirst=K&rft.date=1989-05-01&rft.volume=5&rft.issue=3&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral teratology investigation of 1-butanol in rats. AN - 79135808; 2569163 AB - Two concentrations of 1-butanol (3000 and 6000 ppm) were administered by inhalation to separate groups of 15 pregnant Sprague-Dawley rats for 7 hr per day throughout gestation; 18 male rats were similarly exposed for 7 hr per day for 6 weeks, and mated to unexposed females. Litters were culled to 4 female and 4 male pups and fostered to untreated controls. From days 10-90, offspring were tested as follows: a) ascent on a wire mesh screen, b) rotorod, c) open field and photoelectrically-monitored activity, d) running wheel, e) avoidance conditioning, and f) operant conditioning. Additionally, brains from 10 offspring at 21 days of age were dissected into cerebrum, cerebellum, brainstem, and midbrain. Each sample was assayed for protein and the neurotransmitters acetylcholine, dopamine, norepinephrine, serotonin, met-enkephalin, beta-endorphin, and substance P. Overall, there were few behavioral or neurochemical alterations detected in the offspring following maternal or paternal exposure to either 3000 or 6000 ppm 1-butanol. This scarcity of effects is important to risk assessment extrapolations drawn from ethanol. Based on the structural similarity of 1-butanol to ethanol and long-standing observations that toxicity to adult animals generally increases with chain length among the alcohols, significant behavioral and neurochemical deviations were predicted. The scarcity of effects from butanol needs to be accounted for in hypotheses relating toxicity to alcohol chain length and in risk assessment extrapolations from findings with ethanol. JF - Neurotoxicology and teratology AU - Nelson, B K AU - Brightwell, W S AU - Robertson, S K AU - Khan, A AU - Krieg, E F AU - Massari, V J AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. PY - 1989 SP - 313 EP - 315 VL - 11 IS - 3 SN - 0892-0362, 0892-0362 KW - Butanols KW - 0 KW - Neurotransmitter Agents KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Neurotransmitter Agents -- metabolism KW - Male KW - Female KW - Pregnancy KW - Maternal-Fetal Exchange KW - Behavior, Animal -- drug effects KW - Butanols -- toxicity KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79135808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Behavioral+teratology+investigation+of+1-butanol+in+rats.&rft.au=Nelson%2C+B+K%3BBrightwell%2C+W+S%3BRobertson%2C+S+K%3BKhan%2C+A%3BKrieg%2C+E+F%3BMassari%2C+V+J&rft.aulast=Nelson&rft.aufirst=B&rft.date=1989-05-01&rft.volume=11&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Levels of bacteria, fungi, and endotoxin in bulk and aerosolized corn silage. AN - 79133532; 2757375 AB - Three samples of silage taken from the surface of a silo and from depths of 20 and 45 cm in the silo were studied for identification of the potential agents causing symptoms of organic dust toxic syndrome. The samples were examined by dilution plating before and after aerosolization in an acoustical dust generator. Aerosol samples were collected by liquid impinger and filter cassettes. The samples were examined for total aerobic bacteria, anaerobic bacteria, gram-negative bacteria, lactobacilli, listeriae, thermophilic actinomycetes, fungi, and endotoxin. Very high levels of total aerobic bacteria and fungi were found in the surface sample (up to 10(9) CFU/g in the bulk sample and up to 10(9) CFU/m3 after aerosolization), whereas the corresponding values from the deepest site were 100 to 50,000 times lower. Aspergillus fumigatus predominated among the fungi, whereas Bacillus and gram-negative organisms (Pseudomonas, Alcaligenes, Citrobacter, and Klebsiella species) prevailed among bacteria. Thermophilic actinomycetes occurred in numbers up to 10(7) CFU/g in the bulk samples, whereas anaerobic bacteria, lactobacilli, and listeriae were only few or absent. The concentration of endotoxin was high in the surface sample (up to 211.4 Endotoxin Units/mg) and about 200-fold lower in the sample from the deepest site. The results show that contact with dust from the surface of silage carries the risk of exposure to high concentrations of microorganisms, of which A. fumigatus and endotoxin-producing bacteria are the most probable disease agents. JF - Applied and environmental microbiology AU - Dutkiewicz, J AU - Olenchock, S A AU - Sorenson, W G AU - Gerencser, V F AU - May, J J AU - Pratt, D S AU - Robinson, V A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 1093 EP - 1099 VL - 55 IS - 5 SN - 0099-2240, 0099-2240 KW - Aerosols KW - 0 KW - Dust KW - Endotoxins KW - Index Medicus KW - Bacteria, Anaerobic -- growth & development KW - Zea mays KW - Gram-Negative Bacteria -- growth & development KW - Colony Count, Microbial KW - Bacteria, Anaerobic -- isolation & purification KW - Bacteria, Aerobic -- isolation & purification KW - Gram-Negative Bacteria -- isolation & purification KW - Bacteria, Aerobic -- growth & development KW - Silage KW - Animal Feed KW - Bacteria -- growth & development KW - Bacteria -- isolation & purification KW - Fungi -- isolation & purification KW - Fungi -- growth & development KW - Endotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79133532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Levels+of+bacteria%2C+fungi%2C+and+endotoxin+in+bulk+and+aerosolized+corn+silage.&rft.au=Dutkiewicz%2C+J%3BOlenchock%2C+S+A%3BSorenson%2C+W+G%3BGerencser%2C+V+F%3BMay%2C+J+J%3BPratt%2C+D+S%3BRobinson%2C+V+A&rft.aulast=Dutkiewicz&rft.aufirst=J&rft.date=1989-05-01&rft.volume=55&rft.issue=5&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-28 N1 - Date created - 1989-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Microbiol. 1972 Oct;24(4):638-44 [4628799] J Gen Microbiol. 1963 Jan;30:75-88 [13950271] J Agric Food Chem. 1977 Jul-Aug;25(4):826-30 [328548] Br J Ind Med. 1978 Aug;35(3):204-7 [698133] Arch Environ Health. 1978 Sep-Oct;33(5):250-9 [708119] Arch Environ Health. 1978 Sep-Oct;33(5):260-70 [101155] Clin Allergy. 1979 Jan;9(1):43-52 [421335] Infect Immun. 1983 Apr;40(1):133-8 [6339400] Am Ind Hyg Assoc J. 1982 Nov;43(11):811-2 [7168439] Appl Environ Microbiol. 1983 May;45(5):1501-5 [6347061] Arch Environ Health. 1984 Jan-Feb;39(1):43-8 [6712283] Am Ind Hyg Assoc J. 1984 May;45(5):336-9 [6741783] Toxicol Appl Pharmacol. 1984 Dec;76(3):544-7 [6506079] J Appl Bacteriol. 1985 Dec;59(6):537-43 [3938452] Vet Rec. 1986 Mar 1;118(9):240-2 [3085322] Environ Health Perspect. 1986 Apr;66:91-6 [3709488] Am J Ind Med. 1986;10(3):261-5 [3766553] Am J Ind Med. 1986;10(3):267-73 [3766554] Am J Ind Med. 1986;10(3):300-2 [3766558] Appl Environ Microbiol. 1987 Jun;53(6):1370-5 [3496850] Chest. 1975 Mar;67(3):293-7 [46192] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantification of selected herbicides and chlorinated phenols in urine by using gas chromatography/mass spectrometry/mass spectrometry. AN - 79116218; 2755087 AB - We have developed a method for determining selected chlorinated phenols and phenoxy herbicides in urine. The process of preparing the samples includes acid hydrolysis, extraction with benzene, derivatization with diazoethane, and column chromatography cleanup. We quantify the more volatile compounds by using capillary column gas chromatography/positive chemical ionization/mass spectrometry/mass spectrometry. Less volatile compounds are quantified by using electron capture negative chemical ionization in a single stage mass spectrometry mode. Quality control samples are included in each analytical run, and the results demonstrate that the analytical system is in control. Positive values for the target analytes are determined on the basis of appropriate relative retention time, a signal-to-noise ratio greater than 3:1, and a calculated concentration greater than 1 ppb. We determine the chlorine isotope ratios for each compound to assess the presence or absence of interferences. This analytical method has been applied in a case-control study of 199 individuals to examine exposure to the 12 target analytes. JF - Journal of analytical toxicology AU - Holler, J S AU - Fast, D M AU - Hill, R H AU - Cardinali, F L AU - Todd, G D AU - McCraw, J M AU - Bailey, S L AU - Needham, L L AD - Division of Environmental Health Laboratory Sciences, Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, Georgia 30333. PY - 1989 SP - 152 EP - 157 VL - 13 IS - 3 SN - 0146-4760, 0146-4760 KW - Chlorophenols KW - 0 KW - Herbicides KW - 2,5-dichlorophenol KW - 583-78-8 KW - Index Medicus KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Child KW - Chlorophenols -- urine KW - Herbicides -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79116218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Quantification+of+selected+herbicides+and+chlorinated+phenols+in+urine+by+using+gas+chromatography%2Fmass+spectrometry%2Fmass+spectrometry.&rft.au=Holler%2C+J+S%3BFast%2C+D+M%3BHill%2C+R+H%3BCardinali%2C+F+L%3BTodd%2C+G+D%3BMcCraw%2C+J+M%3BBailey%2C+S+L%3BNeedham%2C+L+L&rft.aulast=Holler&rft.aufirst=J&rft.date=1989-05-01&rft.volume=13&rft.issue=3&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-05 N1 - Date created - 1989-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extraction of light filth from spirulina powders and tablets: collaborative study. AN - 79091665; 2501292 AB - Results are reported for a collaborative study of a method for the extraction of light filth from spirulina (a blue-green alga) powder and tablets. A 50 g portion of either powder or tablets is dispersed in water, and then boiled with dilute HCI solution. Hairs and insect fragments are isolated by wet sieving on a No. 230 sieve, flotation with mineral oil, and washings of the mineral oil in a percolator. Average recoveries by 12 collaborators for tablets and powders were 70.6 and 70.2%, respectively, for 10 rat hair spikes and 68.3 and 84.4%, respectively, for 20 insect fragment spikes. The method has been approved interim official first action. JF - Journal - Association of Official Analytical Chemists AU - Nakashima, M J AU - Angold, S AU - Beavin, B B AU - Bradicich, R B AU - Decker, S J AU - Dzidowski, G R AU - Levesque, E AU - Locatelli, R G AU - Mably, M AU - Paredes, A AD - Food and Drug Administration, Division of Microbiology, Washington, DC 20204. PY - 1989 SP - 451 EP - 453 VL - 72 IS - 3 SN - 0004-5756, 0004-5756 KW - Powders KW - 0 KW - Tablets KW - Index Medicus KW - Powders -- analysis KW - Tablets -- analysis KW - Food Contamination -- analysis KW - Cyanobacteria -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79091665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Extraction+of+light+filth+from+spirulina+powders+and+tablets%3A+collaborative+study.&rft.au=Nakashima%2C+M+J%3BAngold%2C+S%3BBeavin%2C+B+B%3BBradicich%2C+R+B%3BDecker%2C+S+J%3BDzidowski%2C+G+R%3BLevesque%2C+E%3BLocatelli%2C+R+G%3BMably%2C+M%3BParedes%2C+A&rft.aulast=Nakashima&rft.aufirst=M&rft.date=1989-05-01&rft.volume=72&rft.issue=3&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The FDA pesticides program: goals and new approaches. AN - 79088723; 2745382 AB - The U.S. Food and Drug Administration (FDA) has carried out a large-scale monitoring program for pesticide residues in foods since the 1960s. The program has evolved continuously as evidenced by a number of recently incorporated modifications and initiatives. Included are greater emphasis on imports; increased and more specific targeting of pesticide/commodity combinations by geographic area or country; development of individual district sampling plans for domestic and imported foods; expanded use of single residue methods; linkage of information on foreign pesticide usage with food import volumes; development of an analytical methods research plan; and increased cooperative sampling and data exchange with the states. Initiatives to acquire and utilize private sector and other monitoring data are being explored, and aggressive steps are being taken to inform the public of FDA monitoring results in a timely and understandable manner. JF - Journal - Association of Official Analytical Chemists AU - Lombardo, P AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 518 EP - 520 VL - 72 IS - 3 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Food Contamination -- analysis KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79088723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=The+FDA+pesticides+program%3A+goals+and+new+approaches.&rft.au=Lombardo%2C+P&rft.aulast=Lombardo&rft.aufirst=P&rft.date=1989-05-01&rft.volume=72&rft.issue=3&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Survey of lead in canned evaporated milk. AN - 79087587; 2745360 AB - A Food and Drug Administration survey of lead in canned evaporated milk conducted in fiscal year 1985/86 found a mean level of 0.006 micrograms Pb/g. This level is much lower than that found in previous surveys and is attributed to the use of nonlead-soldered cans for packaging evaporated milk. JF - Journal - Association of Official Analytical Chemists AU - Capar, S G AU - Rigsby, E J AD - Food and Drug Administration, Washington, DC 20204. PY - 1989 SP - 416 EP - 417 VL - 72 IS - 3 SN - 0004-5756, 0004-5756 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Animals KW - Food Contamination -- analysis KW - Milk -- analysis KW - Lead -- analysis KW - Food Preservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79087587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Survey+of+lead+in+canned+evaporated+milk.&rft.au=Capar%2C+S+G%3BRigsby%2C+E+J&rft.aulast=Capar&rft.aufirst=S&rft.date=1989-05-01&rft.volume=72&rft.issue=3&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. II: Effects on conjugating enzymes. AN - 79078706; 2500570 AB - The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restriction significantly reduced the age-related decrease in glutathione-S-transferase activity towards 1,2-dichloro-4-nitrobenzene, but did not significantly alter the age-related changes in UDP-glucuronyltransferase or sulfotransferase activities towards hydroxysteroids. Caloric restriction appeared to increase hepatic microsomal UDP-glucuronyltransferase activity toward bilirubin and gamma-glutamyltranspeptidase activities. These observations suggest that caloric restriction has multiple effects on the hepatic phase II drug metabolizing enzymes in the rat. Such effects may alter hepatic metabolism and activation or detoxification of drugs and carcinogens. JF - Mechanisms of ageing and development AU - Leakey, J A AU - Cunny, H C AU - Bazare, J AU - Webb, P J AU - Lipscomb, J C AU - Slikker, W AU - Feuers, R J AU - Duffy, P H AU - Hart, R W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 157 EP - 166 VL - 48 IS - 2 SN - 0047-6374, 0047-6374 KW - Pharmaceutical Preparations KW - 0 KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Sulfotransferases KW - EC 2.8.2.- KW - Epoxide Hydrolases KW - EC 3.3.2.- KW - Index Medicus KW - Rats KW - Epoxide Hydrolases -- metabolism KW - Animals KW - Sulfotransferases -- metabolism KW - Rats, Inbred F344 KW - Pharmaceutical Preparations -- metabolism KW - Inactivation, Metabolic KW - Glucuronosyltransferase -- metabolism KW - Male KW - Aging -- metabolism KW - Liver -- enzymology KW - Glutathione Transferase -- metabolism KW - Energy Intake UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79078706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=Effects+of+aging+and+caloric+restriction+on+hepatic+drug+metabolizing+enzymes+in+the+Fischer+344+rat.+II%3A+Effects+on+conjugating+enzymes.&rft.au=Leakey%2C+J+A%3BCunny%2C+H+C%3BBazare%2C+J%3BWebb%2C+P+J%3BLipscomb%2C+J+C%3BSlikker%2C+W%3BFeuers%2C+R+J%3BDuffy%2C+P+H%3BHart%2C+R+W&rft.aulast=Leakey&rft.aufirst=J&rft.date=1989-05-01&rft.volume=48&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sampling and sample preparation for detection and quantitation of natural toxicants in food and feed. AN - 79077286; 2663833 AB - The primary goal of a sampling plan for natural toxins, i.e., mycotoxins and seafood toxins, is to obtain a sample that accurately represents the concentrations of individual components of a given lot. Factors affecting the ability of the sampling plan to accomplish this goal include: (1) nature of the analyte of interest; (2) distribution of the analyte throughout the lot, (3) physical characteristics of the product, (4) accessibility of the product to random representative sampling, (5) sampling procedure, and (6) size of sample. Sampling plans are composed of 3 distinct components: (a) sampling, (b) sample preparation, and (c) analysis. Normally, sampling contributes the largest relative error while analysis comprises the least. Automatic, continuous stream samplers provide the most representative samples for commodities such as nuts, cottonseed, and cereal grains. Good sample preparation equipment is currently available for these commodities; the use of this equipment to obtain a representative test sample is discussed. JF - Journal - Association of Official Analytical Chemists AU - Park, D L AU - Pohland, A E AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 399 EP - 404 VL - 72 IS - 3 SN - 0004-5756, 0004-5756 KW - Toxins, Biological KW - 0 KW - Index Medicus KW - Food Analysis KW - Animal Feed -- analysis KW - Toxins, Biological -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79077286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Sampling+and+sample+preparation+for+detection+and+quantitation+of+natural+toxicants+in+food+and+feed.&rft.au=Park%2C+D+L%3BPohland%2C+A+E&rft.aulast=Park&rft.aufirst=D&rft.date=1989-05-01&rft.volume=72&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system. AN - 79073228; 2661932 AB - The effects of long-term caloric restriction on the hepatic cytochrome P-450 dependent monooxygenase system were investigated in the 22-month-old Fischer 344 rat. Caloric restriction decreased the age-related changes in hepatic testosterone metabolism, which are associated with demasculinization of the liver. Caloric restriction also increased hepatic microsomal testosterone 6 beta-hydroxylase, lauric acid 12-hydroxylase and 4-nitrophenol hydroxylase activities over corresponding values in both ad libitum fed 22-month and 60-day-old control male rats. This suggests that cytochrome P-450 isozymes, P-450 pcn1&2, P-452 and P450j may be induced by caloric restriction. Such changes in cytochrome P-450 isozyme profiles could result in altered carcinogen activation, radical formation or drug detoxication in the calorically restricted rat. JF - Mechanisms of ageing and development AU - Leakey, J E AU - Cunny, H C AU - Bazare, J AU - Webb, P J AU - Feuers, R J AU - Duffy, P H AU - Hart, R W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 145 EP - 155 VL - 48 IS - 2 SN - 0047-6374, 0047-6374 KW - Isoenzymes KW - 0 KW - Pharmaceutical Preparations KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxygenases KW - EC 1.13.- KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Pharmaceutical Preparations -- metabolism KW - Inactivation, Metabolic KW - Life Expectancy KW - Male KW - Isoenzymes -- metabolism KW - Aging -- metabolism KW - Liver -- enzymology KW - Oxygenases -- metabolism KW - Energy Intake KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79073228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=Effects+of+aging+and+caloric+restriction+on+hepatic+drug+metabolizing+enzymes+in+the+Fischer+344+rat.+I%3A+The+cytochrome+P-450+dependent+monooxygenase+system.&rft.au=Leakey%2C+J+E%3BCunny%2C+H+C%3BBazare%2C+J%3BWebb%2C+P+J%3BFeuers%2C+R+J%3BDuffy%2C+P+H%3BHart%2C+R+W&rft.aulast=Leakey&rft.aufirst=J&rft.date=1989-05-01&rft.volume=48&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Levels of polychlorinated biphenyls and pesticides in bluefish before and after cooking. AN - 79072809; 2501293 AB - Similar levels of polychlorinated biphenyls (PCBs), pesticides, and fat were found in 20 correlated uncooked and cooked (baked) bluefish fillets. Fillets averaged 2.5 ppm PCBs as Aroclor 1254 (whole basis) before cooking; after cooking, with the oil drippings and skin discarded, the average PCB level was 2.7 ppm. Although PCBs, lipophilic pesticides, and fat were lost along with oil drippings and skin that were discarded after cooking, the moisture loss in the fillets during cooking compensated for these weight losses almost completely. After the fillets were cooked and the oil drippings and skin were discarded, the PCB content of the fillets was 27% lower on the average. JF - Journal - Association of Official Analytical Chemists AU - Trotter, W J AU - Corneliussen, P E AU - Laski, R R AU - Vannelli, J J AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 501 EP - 503 VL - 72 IS - 3 SN - 0004-5756, 0004-5756 KW - Pesticide Residues KW - 0 KW - Pesticides KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Animals KW - Chromatography, Gas KW - Pesticides -- analysis KW - Fishes KW - Food Contamination -- analysis KW - Cooking KW - Pesticide Residues -- analysis KW - Polychlorinated Biphenyls -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79072809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Levels+of+polychlorinated+biphenyls+and+pesticides+in+bluefish+before+and+after+cooking.&rft.au=Trotter%2C+W+J%3BCorneliussen%2C+P+E%3BLaski%2C+R+R%3BVannelli%2C+J+J&rft.aulast=Trotter&rft.aufirst=W&rft.date=1989-05-01&rft.volume=72&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The influence of dietary restriction on DNA repair in rodents: a preliminary study. AN - 79058595; 2661931 AB - A range study was undertaken to determine if dietary restriction (DR) affects DNA repair in rodents. Unscheduled DNA synthesis (UDS) was examined in two strains of rat (Brown Norway, BN and Brown Norway X Fischer 344 F1 hybrid, BNF) at 18 months of age. O(6)-Methylguanine-acceptor protein activity (MGAP) was measured across species using rat (Brown Norway X Fischer F-344 F1 hybrid, 18 months) and mouse (B6CB F1 hybrid, 30 months). The rodents were maintained on either an ad libitum (AL) or a restricted diet (60% of the caloric intake of AL rodents). UDS increased approximately 48-65% in freshly isolated skin cells from DR animals opposed to their AL controls after challenge with ultraviolet light (254 nm, 20 J/m2 UV). After treatment with methylmethane sulfonate (0.5 mM MMS), a significant increase in UDS was observed (P less than 0.01, approx, 55% for BN and 52% for BNF rats). Results of measurements for MGAP activity found levels to increase 73% in DR rats and approximately 28% in DR mice when compared to their AL counterparts. In addition MGAP levels in phase shifted mice were examined at three time points during a 24-h period where significant changes were found to occur in the metabolism of DR rodents. The activity of MGAP changed in a circadian fashion with significant increases in MGAP activity in DR mice occurring during the period of highest metabolic activity. JF - Mechanisms of ageing and development AU - Lipman, J M AU - Turturro, A AU - Hart, R W AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 135 EP - 143 VL - 48 IS - 2 SN - 0047-6374, 0047-6374 KW - Guanine KW - 5Z93L87A1R KW - DNA KW - 9007-49-2 KW - O-(6)-methylguanine KW - 9B710FV2AE KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Mice KW - Rats, Inbred BN KW - DNA -- biosynthesis KW - Guanine -- metabolism KW - DNA -- drug effects KW - Methyl Methanesulfonate -- pharmacology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Guanine -- analogs & derivatives KW - DNA -- radiation effects KW - DNA Repair KW - Energy Intake UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79058595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=The+influence+of+dietary+restriction+on+DNA+repair+in+rodents%3A+a+preliminary+study.&rft.au=Lipman%2C+J+M%3BTurturro%2C+A%3BHart%2C+R+W&rft.aulast=Lipman&rft.aufirst=J&rft.date=1989-05-01&rft.volume=48&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of caloric restriction on aflatoxin B1-DNA adduct formation and associated factors in Fischer 344 rats: preliminary findings. AN - 79053750; 2500571 AB - In this first report of an effect of caloric restriction on in vivo DNA binding by a chemical carcinogen in rats, hepatic nuclear binding by aflatoxin B1 (AFB) (pmol/mg DNA) in ad libitum-fed (AL) animals was 2.1 times greater than in rats restricted to 60% of AL consumption for 6 weeks. Data indicating more rapid plasma clearance, increased urinary excretion of the toxin, and less microsome-mediated epoxidation of AFB by the restricted group suggest that decreased macromolecular binding may be attributable in part to metabolic alterations. Moreover, various levels of dietary restriction, initiated at different ages, significantly inhibited hepatic DNA synthesis, thus indicating that effects on cell proliferation could also be involved mechanistically. Finally, circulating levels of the lysosomal enzyme, beta-glucuronidase (beta G), were significantly reduced in the restricted rats, and the implications of this finding regarding potential relationships to aging and carcinogenesis are discussed. JF - Mechanisms of ageing and development AU - Pegram, R A AU - Allaben, W T AU - Chou, M W AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 167 EP - 177 VL - 48 IS - 2 SN - 0047-6374, 0047-6374 KW - Aflatoxins KW - 0 KW - Carcinogens KW - DNA KW - 9007-49-2 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Glucuronidase KW - EC 3.2.1.31 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Glucuronidase -- metabolism KW - Male KW - Aging -- metabolism KW - Aflatoxins -- metabolism KW - Carcinogens -- metabolism KW - DNA -- metabolism KW - Energy Intake KW - DNA -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79053750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=Effect+of+caloric+restriction+on+aflatoxin+B1-DNA+adduct+formation+and+associated+factors+in+Fischer+344+rats%3A+preliminary+findings.&rft.au=Pegram%2C+R+A%3BAllaben%2C+W+T%3BChou%2C+M+W&rft.aulast=Pegram&rft.aufirst=R&rft.date=1989-05-01&rft.volume=48&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contact dermatitis and workers' compensation: criteria for establishing occupational causation and aggravation. AN - 78954723; 2523909 AB - Contact dermatitis is the most common form of occupationally acquired skin disease. Eligibility for coverage under the workers' compensation laws of all states requires only reasonable probability that dermatitis directly resulted from, or was aggravated by, employment. The responsibility for this determination ultimately resides with the examining physician, who must critically evaluate the medical history and cutaneous findings. This article proposes seven objective criteria that may be used to assess the probability of a causal relationship with employment. JF - Journal of the American Academy of Dermatology AU - Mathias, C G AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 842 EP - 848 VL - 20 IS - 5 Pt 1 SN - 0190-9622, 0190-9622 KW - Index Medicus KW - Humans KW - Dermatitis, Occupational -- etiology KW - Dermatitis, Occupational -- economics KW - Workers' Compensation KW - Dermatitis, Contact -- etiology KW - Dermatitis, Contact -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78954723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Contact+dermatitis+and+workers%27+compensation%3A+criteria+for+establishing+occupational+causation+and+aggravation.&rft.au=Mathias%2C+C+G&rft.aulast=Mathias&rft.aufirst=C&rft.date=1989-05-01&rft.volume=20&rft.issue=5+Pt+1&rft.spage=842&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-16 N1 - Date created - 1989-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - DISPOSAL OF CHEMICAL AGENTS AND MUNITIONS STORED AT TOOELE ARMY DEPOT, TOOELE, UTAH. AN - 36390225; 2204 AB - PURPOSE: Implementation of a plan to destroy unitary chemical weapons stored at the Tooele Army Depot (TEAD) in Tooele County, Utah is proposed. TEAD is composed of two areas, TEAD-North and TEAD-South, located 35 miles southwest of Salt Lake City and 38 miles west of Provo. The TEAD-South area, where the chemical agents are stored, covers 19,600 acres; the combined area of TEAD-North and TEAD-South is 44,290 acres. Federal law mandates destruction of the unitary lethal chemical weapons and munitions stockpiled in the United States by April 1997, in conjunction with the acquisition of binary chemical weapons. The vast majority (93.4 percent by weight) of the stockpile is stored in the continental United States (CONUS) at eight Army installations; 42 percent of the total stockpile is stored at TEAD. The agents are of the nerve type, designated as GA, GB, and VX; and of the blister type, designated as H, HD, HT, and L. A final programmatic environmental impact statement for the disposal of the CONUS stockpile was issued in January 1988. Chemicals at TEAD are stored in three configurations: (1) projectiles, cartridges, mines, and rockets containing propellant and/or explosive components; (2) projectiles and aircraft-delivered munitions that do not contain explosive components; and (3) large quantities of bulk agent stored in steel containers. The project at TEAD would involve on-site destruction using the reverse assembly and incineration process of lethal unitary chemical agents and munitions. The disposal facilities would include a munitions demilitarization building that would house the entire disposal process; a container handling building for storage of munitions prior to processing; and associated support facilities needed for operations and maintenance. Other process areas would include the pollution abatement system structures and equipment located adjacent to these demilitarization buildings, the process utilities building, and an enclosed transfer corridor between the container handling building and the munitions demilitarization building. The facility location would be enclosed by a double security fence and would have entry control provisions to ensure control of access. The facility would be physically connected, via security gates, to the existing chemical munitions storage area. Facility construction would require 30 months. POSITIVE IMPACTS: Operations under incident-free conditions would result in minimal impacts to the environment and to plant personnel. A safe, efficient means of disposing of the chemical agents would be provided in concurrence with the congressional mandate. The socioeconomic status of the local area would be improved by an influx of 2,000 individuals and expenditures related to the project. NEGATIVE IMPACTS: Salient impacts would include disposal plant emissions, emissions and safety hazards involved in the transportation of chemical agents and munitions from the storage site to the disposal plant, solid waste generated from incineration of the agents and other wastes, and possible worker exposure to the chemical agents. Approximately 27 acres within the facility would be disturbed, and 33 tons of total suspended particulate emissions would be generated each month; this latter figure is an upper limit estimate. LEGAL MANDATES: Clean Air Act of 1977, as amended (42 U.S.C. 7411 et seq.), Department of Defense Authorization Act of 1984 (P.L. 99-145), Executive Order 12088, and Resource Conservation and Recovery Act of 1976, as amended (42 U.S.C. 6901 et seq.). JF - EPA number: 890107, 213 pages, April 26, 1989 PY - 1989 KW - Defense Programs KW - Archaeological Sites Surveys KW - Chemical Agents KW - Emissions KW - Employment KW - Health Hazards KW - Historic Sites Surveys KW - Impact Assessment Methodology KW - Incineration KW - Military Facilities (Army) KW - Military Operations (Army) KW - Munitions KW - Particulates KW - Safety KW - Safety Analyses KW - Socioeconomic Assessments KW - Waste Disposal KW - Wastes KW - Weapon Systems KW - Utah KW - Clean Air Act of 1977, as amended, Emissions KW - Department of Defense Authorization Act of 1984, Compliance KW - Executive Order 12088, Compliance KW - Resource Conservation and Recovery Act of 1976, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36390225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=DISPOSAL+OF+CHEMICAL+AGENTS+AND+MUNITIONS+STORED+AT+TOOELE+ARMY+DEPOT%2C+TOOELE%2C+UTAH.&rft.title=DISPOSAL+OF+CHEMICAL+AGENTS+AND+MUNITIONS+STORED+AT+TOOELE+ARMY+DEPOT%2C+TOOELE%2C+UTAH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of the Army, Chemical Demilitarization Program, Aberdeen Proving Ground, Maryland; ARMY N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: April 26, 1989 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Analysis, characterization, and purification: requirements for toxicological evaluation of 1,4-dithiane. AN - 79120030; 2753931 AB - 1,4-Dithiane is an organo-sulfur chemical associated with production and storage of munitions. Toxicological evaluation of this chemical was scheduled in rats because of the paucity of such information. Prerequisite for the evaluation was the development of gas chromatographic procedures using flame ionization detection to determine the purity of the test chemical and to certify the concentration and stability of the chemical in the dosage form, sesame oil. Mass and nuclear magnetic resonance spectrometry procedures are described for assessing the structural character and purity of the test chemical. A procedure for the purification of the test chemical and data concerning its solubility in various solvents are also presented. JF - Journal of chromatography AU - Thompson, H C AU - Blakemore, W M AU - Nestorick, D M AU - Freeman, J P AU - Miller, D W AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72029. Y1 - 1989/04/21/ PY - 1989 DA - 1989 Apr 21 SP - 159 EP - 166 VL - 467 IS - 1 KW - Heterocyclic Compounds KW - 0 KW - Sulfur Compounds KW - Water Pollutants KW - Water Pollutants, Chemical KW - 1,4-dithiane KW - 3274B1T5A0 KW - Index Medicus KW - Mass Spectrometry KW - Flame Ionization KW - Chromatography, Gas KW - Magnetic Resonance Spectroscopy KW - Water Pollutants -- analysis KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Heterocyclic Compounds -- analysis KW - Heterocyclic Compounds -- toxicity KW - Heterocyclic Compounds -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79120030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography&rft.atitle=Analysis%2C+characterization%2C+and+purification%3A+requirements+for+toxicological+evaluation+of+1%2C4-dithiane.&rft.au=Thompson%2C+H+C%3BBlakemore%2C+W+M%3BNestorick%2C+D+M%3BFreeman%2C+J+P%3BMiller%2C+D+W&rft.aulast=Thompson&rft.aufirst=H&rft.date=1989-04-21&rft.volume=467&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-07 N1 - Date created - 1989-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol ester and interferon-gamma modulation of epidermal growth factor receptors on human amniotic (WISH) cells. AN - 78917214; 2495278 AB - In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity. Scatchard analysis of EGF binding in the absence of both IFN-gamma and TPA indicated biphasic binding whereas addition of TPA resulted in the loss of the higher affinity class of sites. Pretreatment with IFN-gamma for 24 h enhanced the TPA-induced inhibition of EGF binding whereas IFN-gamma alone had no effect on binding. Protein kinase C (Ca2+/phospholipid-dependent enzyme) was examined as a possible mediator of IFN-induced EGF-receptor modulation; pretreatment of cells with IFN-gamma affected neither the binding of [3H]phorbol 12,13-dibutyrate to membrane or cytosolic fractions nor the protein kinase C activity, suggesting that IFN-gamma pretreatment did not result in translocation or activation of protein kinase C. JF - The Journal of biological chemistry AU - Karasaki, Y AU - Jaken, S AU - Komoriya, A AU - Zoon, K C AD - Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1989/04/15/ PY - 1989 DA - 1989 Apr 15 SP - 6158 EP - 6163 VL - 264 IS - 11 SN - 0021-9258, 0021-9258 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Interferon-gamma KW - 82115-62-6 KW - DNA KW - 9007-49-2 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Cell Survival -- drug effects KW - Humans KW - Cell Compartmentation -- drug effects KW - DNA -- biosynthesis KW - Cell Line KW - Receptor, Epidermal Growth Factor -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Interferon-gamma -- pharmacology KW - Protein Kinase C -- physiology KW - Epidermal Growth Factor -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78917214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Phorbol+ester+and+interferon-gamma+modulation+of+epidermal+growth+factor+receptors+on+human+amniotic+%28WISH%29+cells.&rft.au=Karasaki%2C+Y%3BJaken%2C+S%3BKomoriya%2C+A%3BZoon%2C+K+C&rft.aulast=Karasaki&rft.aufirst=Y&rft.date=1989-04-15&rft.volume=264&rft.issue=11&rft.spage=6158&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes. AN - 78889678; 2495173 AB - Prostaglandin H synthase (PHS), an arachidonic acid-dependent peroxidase, has been implicated in the peroxidative activation of carcinogenic aromatic amines in extrahepatic carcinogen target tissues of experimental animals. We have examined the arachidonic acid-dependent activation of [3H]benzidine to DNA-bound products by microsomal preparations from 75 normal human tissues obtained during necessary surgical procedures. For several samples of urinary bladder epithelium, prostatic epithelium, colonic mucosa, and peripheral lung tissue, an arachidonic acid-dependent, microsomal-catalyzed activation of benzidine was observed; and the activity could be inhibited appreciably by indomethacin, a known inhibitor of PHS. Little or no arachidonic acid-dependent activity was detected in human placenta, breast, or liver microsomes or the majority of colon microsomes. Substrate specificity was also examined with purified ram PHS and with human bladder and with active colon preparations. Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3',2'-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. In comparison, human bladder and colon microsomes catalyzed the activation of benzidine greater than 4-aminobiphenyl, 2-amino-6-methyldipyrido[1,2-alpha:3',2'-d]imidazole, 2-naphthylamine greater than 2-amino-3-methylimidazo[4,5-f]quinoline, 3-amino-1-methyl-5H-pyrido[4,3-b]indole. To confirm the occurrence of PHS antigen in human extrahepatic tissues, an avidin/biotin-amplified competitive enzyme-linked immunoabsorbent assay was developed with purified ram PHS and a commercially available monoclonal antibody known to cross-react with human platelet PHS. The avidin/biotin-amplified enzyme-linked immunosorbent assay, which detected ng quantities of ram PHS, clearly established the presence of the PHS protein in human bladder, prostate, and lung microsomes. In contrast, PHS antigen was not detected in the liver or placental microsomes. The interindividual and tissue-dependent variability of PHS and its role in aromatic amine carcinogenesis are discussed. JF - Cancer research AU - Flammang, T J AU - Yamazoe, Y AU - Benson, R W AU - Roberts, D W AU - Potter, D W AU - Chu, D Z AU - Lang, N P AU - Kadlubar, F F AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/04/15/ PY - 1989 DA - 1989 Apr 15 SP - 1977 EP - 1982 VL - 49 IS - 8 SN - 0008-5472, 0008-5472 KW - Arachidonic Acids KW - 0 KW - Benzidines KW - Carcinogens KW - Peroxides KW - Arachidonic Acid KW - 27YG812J1I KW - benzidine KW - 2X02101HVF KW - DNA KW - 9007-49-2 KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Benzidines -- metabolism KW - Prostaglandin-Endoperoxide Synthases -- physiology KW - Biotransformation KW - Humans KW - In Vitro Techniques KW - Prostaglandin-Endoperoxide Synthases -- analysis KW - Indomethacin -- pharmacology KW - Peroxides -- metabolism KW - Carcinogens -- metabolism KW - Microsomes -- metabolism KW - DNA -- metabolism KW - Arachidonic Acids -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78889678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Arachidonic+acid-dependent+peroxidative+activation+of+carcinogenic+arylamines+by+extrahepatic+human+tissue+microsomes.&rft.au=Flammang%2C+T+J%3BYamazoe%2C+Y%3BBenson%2C+R+W%3BRoberts%2C+D+W%3BPotter%2C+D+W%3BChu%2C+D+Z%3BLang%2C+N+P%3BKadlubar%2C+F+F&rft.aulast=Flammang&rft.aufirst=T&rft.date=1989-04-15&rft.volume=49&rft.issue=8&rft.spage=1977&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-24 N1 - Date created - 1989-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Altered hepatic microsomal function and elevated protooncogene expression as residual effects in rats exposed to delta-9-tetrahydrocannabinol. AN - 78927321; 2540743 AB - The microsomal activation of the potent hepatocarcinogen aflatoxin B1 (AFB1) and the expression of selected protooncogenes were investigated in the livers of rats exposed to delta 9-tetrahydrocannabinol (THC). At equimolar levels of cytochrome P-450, the microsome-mediated binding of AFB1 to DNA was significantly lower (56% of the controls) in preparations from drug exposed rats. Hepatic expression of the c-k-ras protooncogene was 3-fold higher in THC exposed animals. These results suggest the possible occurrence of long lasting residual effects in the rats exposed to THC. JF - Biochemical and biophysical research communications AU - Prasanna, H R AU - Nakamura, K D AU - Ali, S F AU - Lu, M H AU - Slikker, W AU - Hart, R W AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/04/14/ PY - 1989 DA - 1989 Apr 14 SP - 217 EP - 221 VL - 160 IS - 1 SN - 0006-291X, 0006-291X KW - Aflatoxins KW - 0 KW - Proto-Oncogene Proteins KW - Dronabinol KW - 7J8897W37S KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Aflatoxins -- metabolism KW - DNA -- metabolism KW - Glutathione Transferase -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Proto-Oncogene Proteins -- genetics KW - Male KW - Organ Size -- drug effects KW - Liver -- anatomy & histology KW - Liver -- drug effects KW - Microsomes, Liver -- metabolism KW - Dronabinol -- pharmacology KW - Microsomes, Liver -- drug effects KW - Liver -- metabolism KW - Gene Expression Regulation -- drug effects KW - Proto-Oncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78927321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Altered+hepatic+microsomal+function+and+elevated+protooncogene+expression+as+residual+effects+in+rats+exposed+to+delta-9-tetrahydrocannabinol.&rft.au=Prasanna%2C+H+R%3BNakamura%2C+K+D%3BAli%2C+S+F%3BLu%2C+M+H%3BSlikker%2C+W%3BHart%2C+R+W&rft.aulast=Prasanna&rft.aufirst=H&rft.date=1989-04-14&rft.volume=160&rft.issue=1&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic toxicity/carcinogenicity studies of gentian violet in Fischer 344 rats: two-generation exposure. AN - 79044128; 2731819 AB - A chronic feeding study was carried out in the F1a generation of dosed Fischer 344 rats of both sexes with gentian violet (GV). The test substance was administered in the diet to 570 male and 570 female rats at dose levels of 0 (control), 100, 300 and 600 ppm for 24 months. Rats were killed and necropsied after 12, 18 and 24 months of continuous dosing. Measurements of body weights, food consumption (and dose rate) and mortality and the results of histopathological examination were analysed statistically. Male and female rats fed 600 ppm GV for 24 months showed a decrease in body weights. Average food consumption based on g food/kg average body weight was essentially equal in all groups. Mortality at the end of the study (24 months) was approximately 33% in the controls for both males and females and approximately 66% in females of the high-dose group and 48 and 39% in males of the mid- and high-dose groups, respectively. All dose-related neoplastic pathology was noted at the final necropsy. Following 24 months of dosing, there was a significant difference from the controls in the incidence of follicular cell adenocarcinoma of the thyroid gland for both males (600 ppm GV) and females (300 and 600 ppm GV). Although the incidences were very low, statistical analysis showed a significant difference from the controls for hepatocellular adenomas in the mid-dose group of the females and the mid- and high-dose groups of the males. A dose-time-related incidence of mononuclear cell leukaemia was also noted in the females. There was high background incidence of the leukaemia. Several non-neoplastic dose-related lesions were observed in both males and females, principally in the 18- and 24-month necropsies. Almost all of these lesions were focal changes in the liver, many of which were probably related to the mononuclear cell leukaemia. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Littlefield, N A AU - Gaylor, D W AU - Blackwell, B N AU - Allen, R R AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 239 EP - 247 VL - 27 IS - 4 SN - 0278-6915, 0278-6915 KW - Carcinogens KW - 0 KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Animals KW - Software KW - Dose-Response Relationship, Drug KW - Tissue Distribution KW - Eating KW - Rats KW - Rats, Inbred F344 KW - Body Weight -- drug effects KW - Diet KW - Statistics as Topic KW - Leukemia, Experimental -- chemically induced KW - Female KW - Male KW - Neoplasms, Experimental -- chemically induced KW - Gentian Violet -- toxicity KW - Gentian Violet -- administration & dosage KW - Neoplasms, Experimental -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79044128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Chronic+toxicity%2Fcarcinogenicity+studies+of+gentian+violet+in+Fischer+344+rats%3A+two-generation+exposure.&rft.au=Littlefield%2C+N+A%3BGaylor%2C+D+W%3BBlackwell%2C+B+N%3BAllen%2C+R+R&rft.aulast=Littlefield&rft.aufirst=N&rft.date=1989-04-01&rft.volume=27&rft.issue=4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-25 N1 - Date created - 1989-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of selective developmental toxicity of three butanol isomers administered by inhalation to rats. AN - 79040945; 2731662 AB - As part of an ongoing study of the developmental toxicology of industrial alcohols, this report presents the results of the teratology assessments of 1-butanol, 2-butanol, and t-butanol administered by inhalation to rats. Groups of approximately 15 Sprague-Dawley rats were exposed at 8000, 6000, 3500, or 0 ppm 1-butanol, 7000, 5000, 3500, or 0 ppm 2-butanol, or 5000, 3500, 2000, or 0 ppm t-butanol for 7 hr/day on Gestation Days 1-19 (sperm = 0). In each case, the highest concentration was selected to produce maternal toxicity. Dams were sacrificed on Gestation Day 20, and fetuses were individually weighed, tagged, and examined for external malformations. One-half of the fetuses were stained and examined for skeletal abnormalities, and the other half were examined for visceral defects using the Wilson technique. For each butanol isomer examined, the highest concentration (and the intermediate in some cases) was maternally toxic, as manifest by reduced weight gain and feed intake. Even at a maternally toxic dose, and in spite of a dose-dependent reduction in fetal weights for each isomer, the only teratogenicity observed was a slight increase in skeletal malformations (primarily rudimentary cervical ribs), seen with the highest concentration of 1-butanol. Thus, although teratogenicity was observed at 8000 ppm 1-butanol, and developmental toxicity was observed with each of the butyl alcohol isomers studied, concentrations 50 times the current permissible exposure limits for these three butanol isomers do not produce teratogenicity in rats. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Nelson, B K AU - Brightwell, W S AU - Khan, A AU - Burg, J R AU - Goad, P T AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 469 EP - 479 VL - 12 IS - 3 SN - 0272-0590, 0272-0590 KW - Butanols KW - 0 KW - Teratogens KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Eating -- drug effects KW - Animals KW - Fetus -- drug effects KW - Gestational Age KW - Body Weight -- drug effects KW - Isomerism KW - Administration, Inhalation KW - Female KW - Pregnancy KW - Butanols -- administration & dosage KW - Butanols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79040945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Lack+of+selective+developmental+toxicity+of+three+butanol+isomers+administered+by+inhalation+to+rats.&rft.au=Nelson%2C+B+K%3BBrightwell%2C+W+S%3BKhan%2C+A%3BBurg%2C+J+R%3BGoad%2C+P+T&rft.aulast=Nelson&rft.aufirst=B&rft.date=1989-04-01&rft.volume=12&rft.issue=3&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Proto-oncogene expression during retinoic acid-induced neural differentiation of embryonal carcinoma cells. AN - 79025977; 2725075 AB - Proto-oncogene expression is altered in P19 embryonal carcinoma cells during retinoic acid-induced neuronal differentiation. A transient three- to four-fold increase in erbB proto-oncogene expression and a similar although smaller increase in src expression was observed during the period of time when events committing the cells to differentiate were occurring, but prior to the expression of the differentiated phenotype. During the differentiation phase, the only change was a decrease in myc proto-oncogene expression. These changes were not observed in untreated controls, cell treated with retinoic acid while growing as monolayer cultures or with mutants of P19 which did not undergo neuronal differentiation in response to retinoic acid treatment, suggesting some degree of specificity for neuronal differentiation. JF - Mechanisms of ageing and development AU - Nakamura, K D AU - Hart, R W AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 53 EP - 62 VL - 48 IS - 1 SN - 0047-6374, 0047-6374 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Tumor Cells, Cultured KW - Mice, Inbred C3H KW - Mice KW - Tretinoin -- pharmacology KW - Teratoma -- genetics KW - Teratoma -- pathology KW - Proto-Oncogenes KW - Cell Differentiation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79025977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=Proto-oncogene+expression+during+retinoic+acid-induced+neural+differentiation+of+embryonal+carcinoma+cells.&rft.au=Nakamura%2C+K+D%3BHart%2C+R+W&rft.aulast=Nakamura&rft.aufirst=K&rft.date=1989-04-01&rft.volume=48&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-28 N1 - Date created - 1989-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clostridium perfringens food poisoning: use of serotyping in an outbreak setting. AN - 78999873; 2542360 AB - An outbreak of Clostridium perfringens food poisoning occurred among attendees of a firehouse luncheon. The predominant symptoms of diarrhea (100%) and abdominal pain (81%) among case-patients, the mean incubation period (13.4 h), and the mean duration of illness (21.2 h) were all characteristic of C. perfringens enteritis. Roast beef, although not epidemiologically implicated, was the most likely vehicle of transmission. Fecal specimens from case-patients contained a median C. perfringens spore count of greater than 10(6) and yielded isolates that were heat sensitive and predominantly nonhemolytic, produced C. perfringens enterotoxin A, and, in the majority of specimens (four of five), were identical in serotype. Food samples were negative. This outbreak demonstrates that following enumeration of C. perfringens from a suitable number of fecal specimens from case-patients, serotyping of the isolates may be helpful in implicating C. perfringens as the cause of foodborne illness. This is especially true when implicated food items test negative or are no longer available for testing. JF - Journal of clinical microbiology AU - Gross, T P AU - Kamara, L B AU - Hatheway, C L AU - Powers, P AU - Libonati, J P AU - Harmon, S M AU - Israel, E AD - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 660 EP - 663 VL - 27 IS - 4 SN - 0095-1137, 0095-1137 KW - Index Medicus KW - Feces -- microbiology KW - Animals KW - Humans KW - Serotyping KW - Aged KW - Child KW - Gastroenteritis -- epidemiology KW - Child, Preschool KW - Cattle KW - Meat -- poisoning KW - Food Microbiology KW - Clostridium perfringens -- isolation & purification KW - Gastroenteritis -- microbiology KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Maryland KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Clostridium Infections -- epidemiology KW - Disease Outbreaks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78999873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Clostridium+perfringens+food+poisoning%3A+use+of+serotyping+in+an+outbreak+setting.&rft.au=Gross%2C+T+P%3BKamara%2C+L+B%3BHatheway%2C+C+L%3BPowers%2C+P%3BLibonati%2C+J+P%3BHarmon%2C+S+M%3BIsrael%2C+E&rft.aulast=Gross&rft.aufirst=T&rft.date=1989-04-01&rft.volume=27&rft.issue=4&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-03 N1 - Date created - 1989-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Can J Public Health. 1975 Sep-Oct;66(5):388-92 [172212] Lancet. 1977 May 14;1(8020):1046-8 [67498] Lancet. 1977 Jul 16;2(8029):129-30 [69207] Int J Zoonoses. 1982 Jun;9(1):12-32 [6293994] J Bacteriol. 1963 May;85:1094-103 [14044000] J Hyg (Lond). 1980 Jun;84(3):443-56 [6300225] Appl Microbiol. 1963 Jan;11:42-4 [13978944] Appl Microbiol. 1965 May;13:352-7 [14325274] J Infect Dis. 1983 Jan;147(1):167-70 [6296240] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preliminary estimates of the virtually safe dose for tumors obtained from the maximum tolerated dose. AN - 78991788; 2717786 AB - The purpose of this paper was to examine the correlation between the maximum tolerated dose (MTD) and the low-dose estimate of the virtually safe dose (VSD) for animal carcinogens. Chronic bioassay results from the National Cancer Institute/National Toxicology Program carcinogenesis screening program were used. Estimates of the VSD were obtained by linear low-dose extrapolation for which an adequate dose-response relationship existed at the same tumor site in the same sex for both rats and mice. Estimates of the VSD were compared with the MTD for 69 tumor sites from 38 chemicals for rats and mice. The MTDs ranged from high to low toxicity (1 ppb to 4.4% in the diet). The overall geometric mean of the ratio of the MTD to the VSD corresponding to a maximum estimated risk of 10(-6) was 3.8 x 10(5). Of the 138 cases, only 3 cases were more than a factor of 10 from the mean ratio. This suggested that a quick estimate of the VSD could be obtained by dividing the MTD, obtained from a subchronic study, by 400,000. Further, if the human exposure is less than 10(-7) X MTD, the estimated risk is likely to be negligible even if the chemical is a carcinogen. It may not be worthwhile to conduct a chronic bioassay for the purpose of demonstrating a negligible risk, if the chemical is likely to be carcinogenic, unless the human exposure is extremely low.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Regulatory toxicology and pharmacology : RTP AU - Gaylor, D W AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 101 EP - 108 VL - 9 IS - 2 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Maximum Allowable Concentration KW - Mice KW - Male KW - Female KW - Carcinogens -- toxicity KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78991788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Preliminary+estimates+of+the+virtually+safe+dose+for+tumors+obtained+from+the+maximum+tolerated+dose.&rft.au=Gaylor%2C+D+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=1989-04-01&rft.volume=9&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk assessment and the credibility of federal regulatory policy: an FDA perspective. AN - 78977242; 2717788 AB - FDA's fundamental goals are to protect and promote the public health, using the best possible science and the law. The evolution of food safety policy toward potential carcinogens reflects a conscious decision by the agency and Administration to use risk assessment in carrying out these goals. Examples include FDA policies toward assessing the safety of animal drug residues, setting specifications for constituents of food and color additives, and most recently, a common sense de minimis interpretation of the "Delaney clause." While committed to risk assessment as a useful tool, FDA acknowledges that judgments must be made on less than perfect data. In addition, recent history shows that there may be a serious "credibility gap" in public acceptance of regulatory toxicology. To ensure that there is an adequate science base for regulatory decisions, the challenge is twofold: First, the data necessary for sound safety evaluations in individual cases must be developed, based on current knowledge; and, second, the validity of assumptions underlying risk assessment should be tested and refined and scientific consensus achieved. Otherwise, risk management policy will rely on assessments based on extremely conservative assumptions, tending to overestimate risk. Risk assessment assumptions must also be better communicated to policymakers and the public. If these challenges are successfully addressed, public confidence in marketed products, and in science-based regulatory policy, will be enhanced. JF - Regulatory toxicology and pharmacology : RTP AU - Lowe, M F AD - Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 131 EP - 140 VL - 9 IS - 2 SN - 0273-2300, 0273-2300 KW - Saccharin KW - FST467XS7D KW - Index Medicus KW - United States KW - Risk KW - Research KW - Saccharin -- adverse effects KW - Legislation, Food -- trends KW - United States Food and Drug Administration -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78977242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Risk+assessment+and+the+credibility+of+federal+regulatory+policy%3A+an+FDA+perspective.&rft.au=Lowe%2C+M+F&rft.aulast=Lowe&rft.aufirst=M&rft.date=1989-04-01&rft.volume=9&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A note on the role of background tumor incidence in risk assessment for carcinogens. AN - 78954739; 2717789 AB - The extrapolation of animal bioassay data to humans for the purpose of estimating risk from food additives, drugs, pesticides, etc. is still the primary approach to carcinogenic risk assessment. When the extrapolation is based on tumor data with high background incidence (e.g., hepatocellular tumors in rodents), its direct relevance to the human situation is sometimes questioned. This paper suggests a method for adjusting the acceptable excess risk level for humans according to the background incidence of the tumor type used for extrapolating from animals to humans. Application of the suggested "fixed relative risk" extrapolation method in setting acceptable low-risk exposure levels for humans is illustrated for methylene chloride. JF - Regulatory toxicology and pharmacology : RTP AU - Kodell, R L AU - Chen, J J AU - Gaylor, D W AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 141 EP - 146 VL - 9 IS - 2 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Methylene Chloride KW - 588X2YUY0A KW - Index Medicus KW - United States KW - Risk KW - United States Environmental Protection Agency KW - Methylene Chloride -- toxicity KW - Humans KW - Statistics as Topic KW - Neoplasms -- epidemiology KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78954739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=A+note+on+the+role+of+background+tumor+incidence+in+risk+assessment+for+carcinogens.&rft.au=Kodell%2C+R+L%3BChen%2C+J+J%3BGaylor%2C+D+W&rft.aulast=Kodell&rft.aufirst=R&rft.date=1989-04-01&rft.volume=9&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute exposure to formaldehyde induces hepatic metallothionein synthesis in mice. AN - 78948568; 2711395 AB - Humans risk inadvertent intraperitoneal or intravenous exposure to formaldehyde (HCHO), commonly used for disinfection of implanted or extracorporeal medical devices. Various chemical and physical stresses are known to induce hepatic metallothionein. This study examined the effect of acute parenteral administration of HCHO on induction of hepatic metallothionein synthesis. Adult male CF1 mice were administered HCHO ip and hepatic metallothionein was quantified by the cadmium-radioassay method. HCHO (50 mg/kg) increased hepatic metallothionein as early as 8 hr after dosing with maximal levels (27-fold increase) occurring at 72 hr. Metallothionein concentrations were elevated (15-fold) 24 hr after 50 or 100 mg HCHO/kg but not at lower dosages. Concomitant elevations in hepatic zinc and copper content were observed. No increases in metallothionein were observed in kidney, pancreas, or intestine 24 hr after HCHO administration (100 mg/kg, ip). Induction of metallothionein by HCHO may reflect direct de novo synthesis since the response was abolished by pretreatment with the RNA synthesis inhibitor, actinomycin D. HCHO induction of metallothionein also does not appear to be mediated by stress-induced release of corticosteroids or catecholamines from the adrenal since the response was unaltered in adrenalectomized mice. Interference with the glutathione (GSH)-dependent oxidation of HCHO by reducing hepatic GSH concentrations to 40% of control after a 2-hr pretreatment with phorone decreased the metallothionein induction response to HCHO by 33%. This result suggests that the induction may be partially due to a HCHO metabolite, e.g., formate. Confirmation of metallothionein synthesis was obtained following spectral and chromatographic analysis. Thus, HCHO and/or a metabolite produces a marked increase in hepatic metallothionein and alters hepatic zinc and copper homeostasis, all of which are transient responses. Although HCHO was only mildly hepatotoxic at the highest dose (as evidenced by an increase in plasma alanine aminotransferase activity), such changes in metallothionein synthesis and essential metal homeostasis may be part of a cellular repair mechanism operant after acute toxic cell injury. JF - Toxicology and applied pharmacology AU - Goering, P L AD - Division of Life Sciences, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 325 EP - 337 VL - 98 IS - 2 SN - 0041-008X, 0041-008X KW - Glucocorticoids KW - 0 KW - Ketones KW - Formaldehyde KW - 1HG84L3525 KW - Copper KW - 789U1901C5 KW - phorone KW - 8F20OEI0MV KW - Metallothionein KW - 9038-94-2 KW - Glutathione KW - GAN16C9B8O KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Protein Biosynthesis KW - Glucocorticoids -- physiology KW - Animals KW - Zinc -- analysis KW - Glutathione -- metabolism KW - Mice KW - Copper -- analysis KW - Male KW - Ketones -- pharmacology KW - Metallothionein -- biosynthesis KW - Liver -- drug effects KW - Formaldehyde -- metabolism KW - Liver -- metabolism KW - Formaldehyde -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78948568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Acute+exposure+to+formaldehyde+induces+hepatic+metallothionein+synthesis+in+mice.&rft.au=Goering%2C+P+L&rft.aulast=Goering&rft.aufirst=P&rft.date=1989-04-01&rft.volume=98&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of nitrofurantoin and furazolidone in Chinese hamster ovary cell strains. AN - 78920673; 2927439 JF - Mutation research AU - Gao, N AU - Ni, Y C AU - Thornton-Manning, J R AU - Fu, P P AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 181 EP - 187 VL - 225 IS - 4 SN - 0027-5107, 0027-5107 KW - Solvents KW - 0 KW - Furazolidone KW - 5J9CPU3RE0 KW - Nitrofurantoin KW - 927AH8112L KW - Index Medicus KW - Animals KW - Chromosome Deletion KW - Ovary -- cytology KW - Cell Survival -- drug effects KW - Female KW - Cell Line KW - Cricetinae KW - Mutation -- drug effects KW - Mutagenicity Tests KW - Furazolidone -- toxicity KW - Nitrofurantoin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78920673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutagenicity+of+nitrofurantoin+and+furazolidone+in+Chinese+hamster+ovary+cell+strains.&rft.au=Gao%2C+N%3BNi%2C+Y+C%3BThornton-Manning%2C+J+R%3BFu%2C+P+P%3BHeflich%2C+R+H&rft.aulast=Gao&rft.aufirst=N&rft.date=1989-04-01&rft.volume=225&rft.issue=4&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-10 N1 - Date created - 1989-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Triethylene melamine-induced sister-chromatid exchange in murine lymphocytes exposed in vivo. AN - 78917566; 2704383 AB - The induction of sister-chromatid exchange (SCE) by triethylene melamine (TEM), a known animal carcinogen, was investigated in an in vivo exposure/in vitro culture murine lymphocyte assay. Dose-related increases in SCE were observed in B6D2F1 mice following a single i.p. injection of 0.5, 1 or 2 mg/kg TEM. SCE frequencies remained elevated over baseline levels at 24 h post exposure. It is hoped that studies of this nature can determine whether the in vivo/in vitro murine lymphocyte SCE assay is useful for predicting the carcinogenic potential of an agent. JF - Mutation research AU - Neft, R E AU - Schol, H M AU - Casciano, D A AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 323 EP - 328 VL - 222 IS - 4 SN - 0027-5107, 0027-5107 KW - Triethylenemelamine KW - F7IY6HZG9D KW - Index Medicus KW - Lymphocyte Activation KW - Animals KW - Mutagenicity Tests KW - Spleen -- cytology KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - In Vitro Techniques KW - Mice KW - Male KW - Cell Cycle -- drug effects KW - Triethylenemelamine -- toxicity KW - Sister Chromatid Exchange -- drug effects KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78917566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Triethylene+melamine-induced+sister-chromatid+exchange+in+murine+lymphocytes+exposed+in+vivo.&rft.au=Neft%2C+R+E%3BSchol%2C+H+M%3BCasciano%2C+D+A&rft.aulast=Neft&rft.aufirst=R&rft.date=1989-04-01&rft.volume=222&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-25 N1 - Date created - 1989-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of 1-, 3- and 6-nitrosobenzo[a]pyrene in Salmonella typhimurium and Chinese hamster ovary cells. AN - 78898682; 2648140 JF - Mutation research AU - Heflich, R H AU - Unruh, L E AU - Thornton-Manning, J R AU - von Tungeln, L S AU - Fu, P P AD - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 157 EP - 163 VL - 225 IS - 4 SN - 0027-5107, 0027-5107 KW - Benzopyrenes KW - 0 KW - Nitroso Compounds KW - Nitroreductases KW - EC 1.7.- KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Mutagenicity Tests KW - Ovary -- cytology KW - Nitroreductases -- metabolism KW - Cell Survival -- drug effects KW - Biotransformation KW - Salmonella typhimurium -- drug effects KW - Female KW - Cell Line KW - Cricetinae KW - Nitroso Compounds -- metabolism KW - Benzopyrenes -- toxicity KW - Nitroso Compounds -- toxicity KW - Benzopyrenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78898682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutagenicity+of+1-%2C+3-+and+6-nitrosobenzo%5Ba%5Dpyrene+in+Salmonella+typhimurium+and+Chinese+hamster+ovary+cells.&rft.au=Heflich%2C+R+H%3BUnruh%2C+L+E%3BThornton-Manning%2C+J+R%3Bvon+Tungeln%2C+L+S%3BFu%2C+P+P&rft.aulast=Heflich&rft.aufirst=R&rft.date=1989-04-01&rft.volume=225&rft.issue=4&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-10 N1 - Date created - 1989-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A conceptual framework for the validation and use of biologic markers. AN - 78875604; 2647488 AB - Biologic markers have been discussed extensively in the scientific literature in the past 5 years. That literature generally has focused on the promise and limitations of markers. Currently, a great amount of effort is under way in government, academia, and the private sector to move the field forward. This effort may be characterized by the inventory and review of potential markers and their use. The next requirement is to add a consideration of research and design strategies for the validation and use of biologic markers, especially as they pertain to the assessment of xenobiotic exposures and resultant health impairments. This paper delineates a conceptual framework for the validation and use of biologic markers. It expands on the concept of a continuum of events between ambient exposure to a xenobiotic substance and resultant clinical disease. Strategies for research and marker validation are presented. Biologic markers are considered useful in etiologic and mechanistic research, in secondary prevention of disease, in risk assessment, and in assessing the effectiveness of environmental controls. JF - Environmental research AU - Schulte, P A AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 129 EP - 144 VL - 48 IS - 2 SN - 0013-9351, 0013-9351 KW - Biomarkers KW - 0 KW - Index Medicus KW - Evaluation Studies as Topic KW - Disease -- etiology KW - Disease Susceptibility KW - Epidemiologic Methods KW - Risk Factors KW - Humans KW - Environmental Exposure KW - Research Design KW - Meta-Analysis as Topic KW - Biomarkers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78875604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=A+conceptual+framework+for+the+validation+and+use+of+biologic+markers.&rft.au=Schulte%2C+P+A&rft.aulast=Schulte&rft.aufirst=P&rft.date=1989-04-01&rft.volume=48&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-10 N1 - Date created - 1989-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An Agenda for Public Health AN - 61588660; 198901312 AB - Based on personal experience as US Surgeon General over the last seven years, the issues of health promotion & disease prevention are considered, with attention to questions of data development & to international health. These two current challenges for public health leadership in the US are also explored, focusing on changes in the public health landscape under the New Federalism of President Ronald Reagan. Although some perceive the public health system as in disarray, it is argued that the record does not support this view. Confusion between health care & medical care has arisen because those working in public health have not: focused on public health practice in a systematic way, identified the boundaries of the health care delivery system, or insisted on discrete & consistent definitions for practitioners within that system. Unlike the medical care system, there is no accreditation program for graduates of public health educational institutions, & there is no credentialing program for the Master's degree in Public Health. F. S. J. Ledgister JF - Journal of Public Health Policy AU - Koop, Everett C AD - US Public Health Service Dept Health & Human Services, 200 Independence Ave SW Washington DC 20201 Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 7 EP - 18 VL - 10 IS - 1 SN - 0197-5897, 0197-5897 KW - health promotion/disease prevention, public health system KW - personal experience KW - US Surgeon General KW - Prevention KW - Public Health KW - United States of America KW - Health Behavior KW - Organizational Effectiveness KW - article KW - 6124: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61588660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Policy&rft.atitle=An+Agenda+for+Public+Health&rft.au=Koop%2C+Everett+C&rft.aulast=Koop&rft.aufirst=Everett&rft.date=1989-04-01&rft.volume=10&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Policy&rft.issn=01975897&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Organizational Effectiveness; Prevention; Health Behavior; Public Health; United States of America ER - TY - JOUR T1 - Role of Pertussigen (Pertussis Toxin) on the Mouse Protective Activity of Vaccines Made from Bordetella Species AN - 1492612594; 18826496 AB - Pertussigen [pertussis toxin (Ptx)] from Bordetella pertussis, when detoxified, induces protection in mice to intracerebral challenge (ic) with virulent B. pertussis. In its native form, minute nonprotective doses promote the development of immunity induced by other antigens of B. pertussis. As little as 4 ng of Ptx, given with a nonprotective dose of 8 10 super(7) killed cells of the phase III Sakairi strain, promoted detectable protection to ic challenge. Native Ptx in doses of 0.4 to 400 ng did not protect mice, and vaccines made from strains not producing Ptx induced only weak protection. The marked enhancing action of Ptx was also observed with 5 mu g of purified filamentous hemagglutinin and with vaccines made from other species of the Bordetella genus, such as B. parapertussis and B. bronchiseptica, but it was not observed with B. pertussis endotoxin. In addition, Ptx was still effective when given as late as 7 days after the vaccine. Antibodies to surface antigens of the challenge strain were demonstrated in sera of mice immunized with vaccines prepared with the different Bordetella species tested, but antibodies to Ptx were detected only in the sera of mice immunized with the wild-type B. pertussis strains. Glutaraldehyde detoxified Ptx does not have this action. Pretreatment of normal mice with Ptx, also enhanced the protective action of a mouse antiserum to a wild-type strain of B. pertussis. These observations show that antigens other than Ptx are responsible for the protection, and that Ptx acts non-specifically to enhance the mouse protective action of those antigens. JF - Microbiology and Immunology AU - Munoz, John J AU - Peacock, Marius G AD - Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, Montana, 59840, U.S.A. Y1 - 1989/04// PY - 1989 DA - Apr 1989 SP - 341 EP - 355 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 33 IS - 4 SN - 0385-5600, 0385-5600 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Pertussis KW - Bordetella pertussis KW - Antibodies KW - Bordetella KW - surface antigens KW - Hemagglutinins KW - Vaccines KW - Immunity KW - Glutaraldehyde KW - pertussis toxin KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492612594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+and+Immunology&rft.atitle=Role+of+Pertussigen+%28Pertussis+Toxin%29+on+the+Mouse+Protective+Activity+of+Vaccines+Made+from+Bordetella+Species&rft.au=Munoz%2C+John+J%3BPeacock%2C+Marius+G&rft.aulast=Munoz&rft.aufirst=John&rft.date=1989-04-01&rft.volume=33&rft.issue=4&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Microbiology+and+Immunology&rft.issn=03855600&rft_id=info:doi/10.1111%2Fj.1348-0421.1989.tb01982.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Endotoxins; Pertussis; Antibodies; surface antigens; Hemagglutinins; Immunity; Vaccines; Glutaraldehyde; pertussis toxin; Bordetella pertussis; Bordetella DO - http://dx.doi.org/10.1111/j.1348-0421.1989.tb01982.x ER - TY - JOUR T1 - Metabolic activation of aromatic amine carcinogens in vitro and in vivo. AN - 79087066; 2664951 JF - Journal of UOEH AU - Beland, F A AD - National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/03/20/ PY - 1989 DA - 1989 Mar 20 SP - 387 EP - 397 VL - 11 Suppl SN - 0387-821X, 0387-821X KW - Amines KW - 0 KW - Carcinogens KW - Isoenzymes KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Urinary Bladder -- metabolism KW - Animals KW - Liver Neoplasms -- metabolism KW - 2-Acetylaminofluorene -- toxicity KW - 2-Acetylaminofluorene -- metabolism KW - Dose-Response Relationship, Drug KW - DNA -- metabolism KW - Liver Neoplasms -- chemically induced KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Organ Specificity KW - Mice KW - Mice, Inbred BALB C KW - Isoenzymes -- metabolism KW - DNA -- drug effects KW - Hydroxylation KW - Rats KW - Acetylation KW - Biotransformation KW - Substrate Specificity KW - Urinary Bladder Neoplasms -- metabolism KW - Female KW - Urinary Bladder Neoplasms -- chemically induced KW - Carcinogens -- metabolism KW - Carcinogens -- pharmacokinetics KW - Amines -- metabolism KW - Amines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79087066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+UOEH&rft.atitle=Metabolic+activation+of+aromatic+amine+carcinogens+in+vitro+and+in+vivo.&rft.au=Beland%2C+F+A&rft.aulast=Beland&rft.aufirst=F&rft.date=1989-03-20&rft.volume=11+Suppl&rft.issue=&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Journal+of+UOEH&rft.issn=0387821X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-14 N1 - Date created - 1989-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Otitis media in the first year of life in two Eskimo communities. AN - 85180895; pmid-2784300 AB - Severe otitis media of early onset is particularly prevalent among Eskimo infants. An investigation of health records of all infants born in 1984 and served by two health facilities was undertaken to assess the relative significance of three particular variables associated with this problem: 1) sex versus age, 2) sex versus severity, and 3) sex versus other health conditions. Ninety-five percent of the children in one locale and 74.4% in the other had at least one episode during the first year of life. While none of the comparisons were statistically significant, infants at the northernmost community were generally more severely affected; females in each community were found to have 1) fewer and less severe episodes of disease, 2) the first episode at a later age, 3) fewer episodes during the year, and 4) fewer episodes of bilateral disease. JF - The Annals of Otology, Rhinology, and Laryngology AU - Stewart, J L AD - Sensory Disabilities Program, Indian Health Service, Albuquerque, New Mexico. PY - 1989 SP - 200 EP - 201 VL - 98 IS - 3 SN - 0003-4894, 0003-4894 KW - Infant KW - Cross-Sectional Studies KW - Age Factors KW - Sex Factors KW - Humans KW - Otitis Media KW - Alaska KW - Female KW - Male KW - Inuits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85180895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Otitis+media+in+the+first+year+of+life+in+two+Eskimo+communities.&rft.au=Stewart%2C+J+L&rft.aulast=Stewart&rft.aufirst=J&rft.date=1989-03-01&rft.volume=98&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Stemphyltoxin III from Alternaria alternata. AN - 79105187; 2746264 AB - Stemphyltoxin III, (6aR*, 6bS*, 7R*, 8R*)-3,6a, 10-trihydroxy-4,9-dioxo-4,6a,6b,7,8,9-hexahydro-7,8-epoxyperylene, a known metabolite of Stemphylium botryosum var. lactucum, has been identified as a mutagenic metabolite of Alternaria alternata by spectroscopic studies. The 13C-nmr spectral data, which were not reported previously, are presented. JF - Journal of natural products AU - Stack, M E AU - Mazzola, E P AD - Division of Contaminants Chemistry, Food and Drug Administration, Washington, D.C. 20204. PY - 1989 SP - 426 EP - 427 VL - 52 IS - 2 SN - 0163-3864, 0163-3864 KW - Benz(a)Anthracenes KW - 0 KW - Mutagens KW - stemphyltoxin III KW - 102694-32-6 KW - Perylene KW - 5QD5427UN7 KW - Index Medicus KW - Magnetic Resonance Spectroscopy KW - Perylene -- analogs & derivatives KW - Alternaria -- analysis KW - Perylene -- analysis KW - Perylene -- isolation & purification KW - Mitosporic Fungi -- analysis KW - Benz(a)Anthracenes -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79105187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Stemphyltoxin+III+from+Alternaria+alternata.&rft.au=Stack%2C+M+E%3BMazzola%2C+E+P&rft.aulast=Stack&rft.aufirst=M&rft.date=1989-03-01&rft.volume=52&rft.issue=2&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=01633864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protection against isoproterenol-induced myocardial necrosis in rats by 6-mercaptopurine and 6-thioguanine or by irradiation. AN - 79038896; 2727390 AB - Isoproterenol produces myocardial necrosis in rats. To investigate the possible role of oxygen free radicals generated by xanthine oxidase and neutrophils, we examined the effects of the xanthine oxidase inhibitors, 6-mercaptopurine (6MP) and 6-thioguanine (6TG) combined and allopurinol, or of irradiation (to induce leukopenia) on isoproterenol-induced myocardial necrosis (ISOMN). The incidence and severity of ISOMN was significantly reduced by 6MP + 6TG but not by the specific inhibitor of xanthine oxidase, allopurinol, indicating that the protective effects of 6MP + 6TG may be due to its free radical scavenging activity rather than its xanthine oxidase inhibitory activity. Irradiation provided complete protection against ISOMN in all rats. Marked leukopenia or other radiation-induced protective factors could play a role in the mechanism of the protection. JF - Research communications in chemical pathology and pharmacology AU - Joseph, X AU - Balazs, T AD - Division of Research and Testing, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 385 EP - 394 VL - 63 IS - 3 SN - 0034-5164, 0034-5164 KW - Allopurinol KW - 63CZ7GJN5I KW - 6-Mercaptopurine KW - E7WED276I5 KW - Thioguanine KW - FTK8U1GZNX KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Allopurinol -- pharmacology KW - Necrosis KW - Leukopenia -- physiopathology KW - Myocardium -- pathology KW - Leukocytes -- physiology KW - Radiation Injuries, Experimental -- blood KW - Male KW - Leukocytes -- drug effects KW - Isoproterenol -- antagonists & inhibitors KW - Heart Diseases -- chemically induced KW - Heart Diseases -- prevention & control KW - 6-Mercaptopurine -- pharmacology KW - Isoproterenol -- toxicity KW - Thioguanine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79038896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Protection+against+isoproterenol-induced+myocardial+necrosis+in+rats+by+6-mercaptopurine+and+6-thioguanine+or+by+irradiation.&rft.au=Joseph%2C+X%3BBalazs%2C+T&rft.aulast=Joseph&rft.aufirst=X&rft.date=1989-03-01&rft.volume=63&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-29 N1 - Date created - 1989-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human neurobehavioral toxicology testing: current perspectives. AN - 79033865; 2728013 AB - Standardized tests or test batteries for neurotoxic effects are needed for premarket testing of chemicals (and related regulatory needs) and for the development of a neurotoxicity data base. Three widely known human test batteries based on past research findings and developed to screen for a broad range of neurotoxic effects are currently in use. One was developed by Finland's Institute of Occupational Health, one was recently recommended by the World Health Organization, and one was recently developed as a computer-implemented battery by US researchers. Each of these batteries assesses many frequently occurring neurotoxic effects, but each is limited by the lack of tests for some motor and sensory functions and affective responses that often occur following chemical exposures. Problems with field or worksite assessments using these test batteries involve age, education, socioeconomic, and job differences between exposed and comparison groups, and the lack of normative data on these batteries. To address some of these problems, the human neurobehavioral test batteries are currently undergoing reliability or validity assessments on a national and international scale. This will provide an assessment of their utility and accelerate development of a data base of neurotoxic effects of chemicals. JF - Toxicology and industrial health AU - Anger, W K AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 165 EP - 180 VL - 5 IS - 2 SN - 0748-2337, 0748-2337 KW - Index Medicus KW - United States KW - World Health Organization KW - Humans KW - Environmental Exposure KW - National Institute for Occupational Safety and Health (U.S.) KW - Behavior -- drug effects KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79033865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Human+neurobehavioral+toxicology+testing%3A+current+perspectives.&rft.au=Anger%2C+W+K&rft.aulast=Anger&rft.aufirst=W&rft.date=1989-03-01&rft.volume=5&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-26 N1 - Date created - 1989-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral teratology investigation of 1-propanol administered by inhalation to rats. AN - 79029271; 2733653 AB - Due to their structural similarity to ethanol, a human teratogen, and their widespread use in industry, a series of industrial alcohols are being investigated for developmental toxicity. This paper presents the results of exposures to 7000 ppm 1-propanol, which is minimally toxic to maternal animals and produces a low incidence of teratogenicity, and to 3500 ppm 1-propanol, which is not toxic to maternal rats and produces no teratogenicity. Propanol vapors or filtered air was administered for 7 hr/day to 15 pregnant Sprague-Dawley rats throughout gestation or to 18 male rats daily for 6 weeks. Tests of offspring were: a) ascent on a wire mesh screen b) rotorod, c) open field and optically monitored activity, d) running wheel, e) avoidance conditioning, and f) progressive fixed ratio schedule of reinforcement. Brains from 10 rats per group were dissected into cerebrum, cerebellum, brainstem, and midbrain, and were assayed for protein, acetylcholine, dopamine, norepinephrine, serotonin, beta-endorphin, Met-enkephalin, and substance P. Overall, the results indicate that exposure to high concentrations of 1-propanol can affect fertility in exposed males (only 2 of 17 produced litters), but there were no consistent effects seen in the behavioral or neurochemical tests measured. This lack of effects is surprising based on predictions from the structural similarity of 1-propanol to ethanol, and on long-standing observations that toxicity (to adult animals) increases with carbon chain length among the aliphatic alcohols. JF - Neurotoxicology and teratology AU - Nelson, B K AU - Brightwell, W S AU - Taylor, B J AU - Khan, A AU - Burg, J R AU - Krieg, E F AU - Massari, V J AD - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226. PY - 1989 SP - 153 EP - 159 VL - 11 IS - 2 SN - 0892-0362, 0892-0362 KW - Teratogens KW - 0 KW - 1-Propanol KW - 96F264O9SV KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Reference Values KW - Circadian Rhythm -- drug effects KW - Appetite -- drug effects KW - Avoidance Learning -- drug effects KW - Pregnancy KW - Rats, Inbred Strains KW - Rats KW - Handling (Psychology) KW - Exploratory Behavior -- drug effects KW - Motor Activity -- drug effects KW - Administration, Inhalation KW - Female KW - Male KW - Behavior, Animal -- drug effects KW - 1-Propanol -- toxicity KW - 1-Propanol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79029271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Behavioral+teratology+investigation+of+1-propanol+administered+by+inhalation+to+rats.&rft.au=Nelson%2C+B+K%3BBrightwell%2C+W+S%3BTaylor%2C+B+J%3BKhan%2C+A%3BBurg%2C+J+R%3BKrieg%2C+E+F%3BMassari%2C+V+J&rft.aulast=Nelson&rft.aufirst=B&rft.date=1989-03-01&rft.volume=11&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-21 N1 - Date created - 1989-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food and Drug Administration: approach to evaluating neurotoxicity. AN - 79026433; 2728012 AB - One of the primary features of the mission of the Food and Drug Administration is to assure with reasonable certainty that no harm will result from the intended use of chemicals added to food. In carrying out this mission the FDA uses a structured process to assess the safety of each food chemical. The detailed mechanics of this process are described in an FDA document entitled "Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Use in Food" (Food and Drug Administration, 1982). Central to its evaluation the FDA requires a collective set of information, including estimates of the anticipated human exposure to the food chemical and a broad-based toxicological profile. Certainly, any adverse effect observed in the nervous system is recognized as an important element in the determination of chemical safety and follow-up information which would enable an assessment of such an effect to be included in the toxicological profile. The agency's current approach to evaluating neurotoxicity should be viewed within the context of its overall strategy for the safety assessment of food chemicals. Four basic premises underlie the FDA's approach to safety assessment. JF - Toxicology and industrial health AU - Sobotka, T J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 157 EP - 164 VL - 5 IS - 2 SN - 0748-2337, 0748-2337 KW - Food Additives KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Animals KW - Drug Evaluation, Preclinical KW - United States Food and Drug Administration KW - Nervous System -- drug effects KW - Food Additives -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79026433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Food+and+Drug+Administration%3A+approach+to+evaluating+neurotoxicity.&rft.au=Sobotka%2C+T+J&rft.aulast=Sobotka&rft.aufirst=T&rft.date=1989-03-01&rft.volume=5&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-26 N1 - Date created - 1989-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transplacental estrogen responses in the fetal rat: increased uterine weight and ornithine decarboxylase activity. AN - 79025122; 2727933 AB - The synthetic estrogens, diethylstilbestrol (DES) and ethynylestradiol (EE2), are more potent than 17 beta-estradiol (E2) in inducing uterine weight gain in the neonatal rat, due to the binding of E2 to serum alpha-fetoprotein (AFP). However, all three hormones are equipotent in inducing neonatal uterine ornithine decarboxylase (ODC) activity. The present study assessed estrogen potency in fetal rats. Pregnant CD rats were injected sc daily on gestation days (GD) 16-20 with DES, EE2, or E2 in sesame oil. Both DES and EE2, but not E2, significantly increased uterine weight at birth, to more than twice that of controls. In addition, implants which continuously release E2 only slightly increased uterine weight at birth. Alternatively, dams were given a single estrogen injection on GD 20 and were sacrificed at various times after injection. Peak fetal uterine ODC activity occurred at 6-8 hours after maternal injection for all three estrogens. E2 had a relative potency about tenfold less than either DES or EE2 in stimulating fetal ODC activity, in contrast to equal potencies of the three estrogens in the postnatal rat uterus. Similar patterns were found following direct fetal injection with E2 or DES. In summary, these data demonstrate a transplacental induction of fetal uterine ODC activity and uterine weight gain by both DES and EE2. In addition, the lack of correlation between these endpoints in response to E2 suggests that they may be useful as selective indicators of potential toxicity of both natural and synthetic estrogens. JF - Teratology AU - Harmon, J R AU - Branham, W S AU - Sheehan, D M AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 253 EP - 260 VL - 39 IS - 3 SN - 0040-3709, 0040-3709 KW - Drug Implants KW - 0 KW - Teratogens KW - Ethinyl Estradiol KW - 423D2T571U KW - Estradiol KW - 4TI98Z838E KW - Diethylstilbestrol KW - 731DCA35BT KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Index Medicus KW - Rats KW - Maternal-Fetal Exchange KW - Animals KW - Infusion Pumps KW - Fetus -- drug effects KW - Dose-Response Relationship, Drug KW - Female KW - Pregnancy KW - Organ Size -- drug effects KW - Ornithine Decarboxylase -- metabolism KW - Estradiol -- administration & dosage KW - Diethylstilbestrol -- toxicity KW - Estradiol -- toxicity KW - Uterus -- abnormalities KW - Ethinyl Estradiol -- toxicity KW - Ethinyl Estradiol -- administration & dosage KW - Diethylstilbestrol -- administration & dosage KW - Uterus -- enzymology KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79025122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Transplacental+estrogen+responses+in+the+fetal+rat%3A+increased+uterine+weight+and+ornithine+decarboxylase+activity.&rft.au=Harmon%2C+J+R%3BBranham%2C+W+S%3BSheehan%2C+D+M&rft.aulast=Harmon&rft.aufirst=J&rft.date=1989-03-01&rft.volume=39&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-06 N1 - Date created - 1989-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The disposition of 14C-trimethyltin in the pregnant rat and fetus. AN - 79022831; 2733656 AB - Trimethyltin (TMT) is a potent neurotoxicant. For unknown reasons, age at exposure to TMT may dramatically influence the severity of TMT-induced neuropathology. We have demonstrated previously that radiolabel derived from [14C]-TMT given to pregnant dams on gestational day (GD) 17 is found in fetal brain and blood. The present study was designed to determine the distribution of radiolabel derived from [14C]-TMT to brain and other tissue in fetuses from dams dosed on either GD 12 or 17 with 7.0 mg/kg TMT chloride. Radioactivity in GD 12 and GD 17 maternal whole blood peaked 1 hour after IP treatment. Whole blood elimination half-lives were 12-15 days. Peak radiolabel concentrations in GD 12 maternal and fetal brain were only 11-30% of those from GD 17 animals, however, peak fetal brain concentrations of radiolabel were not different from their respective maternal brain concentrations. Radiolabel concentrations in liver, kidney, and adrenal of GD 17 dams were higher than those in corresponding GD 12 tissues. Combined urinary and fecal elimination of radiolabel for two weeks after dosing accounted for 31 and 22% of the GD 12 and 17 doses, respectively. It appears that gestational age influences the distribution and elimination of TMT in the rat. JF - Neurotoxicology and teratology AU - Lipscomb, J C AU - Paule, M G AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. PY - 1989 SP - 185 EP - 191 VL - 11 IS - 2 SN - 0892-0362, 0892-0362 KW - Carbon Radioisotopes KW - 0 KW - Trialkyltin Compounds KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Maternal-Fetal Exchange KW - Animals KW - Aging KW - Tissue Distribution KW - Female KW - Pregnancy KW - Trimethyltin Compounds -- pharmacokinetics KW - Pregnancy, Animal -- metabolism KW - Fetus -- metabolism KW - Trialkyltin Compounds -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79022831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=The+disposition+of+14C-trimethyltin+in+the+pregnant+rat+and+fetus.&rft.au=Lipscomb%2C+J+C%3BPaule%2C+M+G%3BSlikker%2C+W&rft.aulast=Lipscomb&rft.aufirst=J&rft.date=1989-03-01&rft.volume=11&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-21 N1 - Date created - 1989-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ion-exchange chromatographic determination of hypoglycin A in canned ackee fruit. AN - 78943011; 2708289 AB - An ion-exchange chromatographic method was developed to determine hypoglycin A (HG-A) levels in canned ackee fruit by using an amino acid analyzer. HG-A was extracted by homogenizing the sample in 80% alcohol. An isocratic buffer system, consisting of 30% sodium citrate buffer (pH 3.15) and 70% sodium chloride-sodium acetate buffer (pH 7.40) was used to obtain baseline separation between HG-A and the other amino acids. The system can detect HG-A levels as low as 4.8 micrograms/mL. HG-A levels in the edible portion of fruit in 6 cans ranged from 11.0 to 66.5 mg HG-A/can. Recoveries by standard addition averaged 102.5%. JF - Journal - Association of Official Analytical Chemists AU - Chase, G W AU - Landen, W O AU - Gelbaum, L T AU - Soliman, A G AD - Food and Drug Administration, Atlanta, GA 30309. PY - 1989 SP - 374 EP - 377 VL - 72 IS - 2 SN - 0004-5756, 0004-5756 KW - Amino Acids KW - 0 KW - Cyclopropanes KW - Hypoglycins KW - Index Medicus KW - Amino Acids -- analysis KW - Chromatography, Ion Exchange KW - Magnetic Resonance Spectroscopy KW - Hypoglycins -- analysis KW - Cyclopropanes -- analysis KW - Fruit -- analysis KW - Food Preservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78943011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Ion-exchange+chromatographic+determination+of+hypoglycin+A+in+canned+ackee+fruit.&rft.au=Chase%2C+G+W%3BLanden%2C+W+O%3BGelbaum%2C+L+T%3BSoliman%2C+A+G&rft.aulast=Chase&rft.aufirst=G&rft.date=1989-03-01&rft.volume=72&rft.issue=2&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Worldwide occurrence of mycotoxins in foods and feeds--an update. AN - 78923243; 2651391 AB - In a review presented at the first FAO/WHO/UNEP Conference on Mycotoxins in 1977, the occurrence of aflatoxins, zearalenone, ochratoxin A, citrinin, trichothecenes, patulin, penicillic acid, and the ergot alkaloids was indicated to be significant in naturally contaminated foods and feeds. The information presented on aflatoxin contamination greatly exceeded that for all other mycotoxins combined. This study reviews the worldwide levels and occurrence of mycotoxins in various commodities since 1976. Comparatively few countries have lowered the acceptable levels for aflatoxins in susceptible commodities. However, intensified efforts are needed to establish control of aflatoxin levels in the global food supply, particularly in peanuts, tree nuts, corn, and animal feeds. Extensive deoxynivalenol (DON) contamination of grains, especially wheat, was demonstrated. Co-contamination of grains by Fusarium toxins, especially DON and nivalenol, with zearalenone to a lesser extent, was reported. However, more information on co-occurrence of Fusarium toxins in cereals should be developed. When contamination of feeds by ochratoxin A was significant, this toxin occurred in swine kidney and smoked meats in high levels. On the basis of occurrence and/or toxicity, patulin and penicillic acid contamination of foods does not appear to be of real concern. More recent developments suggest, however, that expanded monitoring studies of Alternaria toxins, moniliformin, citrinin, cyclopiazonic acid, penitrem A, and ergot alkaloids are indicated. JF - Journal - Association of Official Analytical Chemists AU - Jelinek, C F AU - Pohland, A E AU - Wood, G E AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 223 EP - 230 VL - 72 IS - 2 SN - 0004-5756, 0004-5756 KW - Mycotoxins KW - 0 KW - Index Medicus KW - Food Contamination -- analysis KW - Animal Feed -- analysis KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78923243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Worldwide+occurrence+of+mycotoxins+in+foods+and+feeds--an+update.&rft.au=Jelinek%2C+C+F%3BPohland%2C+A+E%3BWood%2C+G+E&rft.aulast=Jelinek&rft.aufirst=C&rft.date=1989-03-01&rft.volume=72&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food counseling for persons infected with HIV: strategy for defensive living. AN - 78918697; 2495555 AB - More than a million people in the United States are now infected with human immunodeficiency virus (HIV), and by 1991, the United States will record 270,000 cases of acquired immunodeficiency syndrome (AIDS). At present, there is no way to estimate the number of AIDS patients who will be living in 1991. Intestinal diseases exert considerable morbidity and mortality on AIDS patients and persons with AIDS-related complex. The elevated frequency of certain intestinal infectious diseases in homosexual male AIDS patients has been attributed to sexual practices, but food seems a probable vector for some proportion of the infections in all AIDS-affected groups. Intestinal infectious diseases and resulting systemic infections can be life-threatening to AIDS patients. The infections may serve as cofactors that hasten HIV disease progression to AIDS, but absolute proof of this hypothesis is lacking. The longer the HIV-infected person maintains good general health and avoids potentially lethal infectious diseases, the better are the chances that effective treatments will be developed and made available. Foodborne diseases are generally avoidable, and increased education of AIDS patients and their physicians as to their nature is the key to their prevention. JF - Public health reports (Washington, D.C. : 1974) AU - Archer, D L AD - Division of Microbiology, FDA, Washington, DC 20204. PY - 1989 SP - 196 EP - 198 VL - 104 IS - 2 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Disease Vectors KW - Humans KW - Food Handling KW - AIDS-Related Complex KW - Female KW - Pregnancy KW - Food Microbiology KW - Opportunistic Infections -- prevention & control KW - Acquired Immunodeficiency Syndrome KW - Counseling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78918697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Food+counseling+for+persons+infected+with+HIV%3A+strategy+for+defensive+living.&rft.au=Archer%2C+D+L&rft.aulast=Archer&rft.aufirst=D&rft.date=1989-03-01&rft.volume=104&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1987 Aug;107(2):234-42 [3300461] J Infect Dis. 1987 Dec;156(6):998-1002 [3680999] Clin Microbiol Rev. 1988 Oct;1(4):377-98 [3069199] J Infect Dis. 1988 Sep;158(3):668 [3411158] Nature. 1988 Jun 9;333(6173):519-22 [3287174] Ann Intern Med. 1988 Apr;108(4):540-6 [3348562] Ann Intern Med. 1988 Mar;108(3):328-33 [2829677] Science. 1988 Feb 5;239(4840):617-22 [3277274] Am J Med. 1988 Jan;84(1):162-4 [3276181] Rev Infect Dis. 1987 Sep-Oct;9(5):925-34 [3317736] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enzyme-linked immunosorbent assay for screening aflatoxin B1 in cottonseed products and mixed feed: collaborative study. AN - 78915344; 2496100 AB - A joint AOAC/IUPAC (International Union of Pure and Applied Chemistry) interlaboratory study of an enzyme-linked immunosorbent screening assay (ELISA) for aflatoxins was conducted in laboratories in Canada, France, Japan, South Africa, Switzerland, The Netherlands, Tunisia, and the United States. Twenty-eight samples of raw and roasted peanuts, corn, whole cottonseed, cottonseed meal, ammoniated cottonseed meal, and poultry feed containing various quantities of natural aflatoxins and supplemented when appropriate with aflatoxin B1 were distributed to participating laboratories for testing. The assay is based on conjugation of pure aflatoxin B1 to an enzyme and the competition between this conjugate and (free) aflatoxins in the product for aflatoxin-specific antibodies coated onto microtiter well walls. After a wash step to remove all unbound aflatoxins, a substrate, added to each well, is catalyzed from a colorless to a green solution by any bound enzyme-conjugated aflatoxin B1 present. The intensity of the color decreases as the amount of free aflatoxin B1 in the product increases. Overall correlation was good between ELISA and thin-layer chromatographic (TLC) results for cottonseed products and mixed feed. Variable results were reported for corn and peanut product samples. Although some positive samples (greater than 15 ng/g) of cottonseed products and mixed feed were reported to contain less than 15 ng/g by visual determination, a review of data for absorbance measurements showed that the contamination level was close to the greater than or equal to 15 ng/g standard and would not have been reported as negative under routine screening.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal - Association of Official Analytical Chemists AU - Park, D L AU - Miller, B M AU - Hart, L P AU - Yang, G AU - McVey, J AU - Page, S W AU - Pestka, J AU - Brown, L H AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 326 EP - 332 VL - 72 IS - 2 SN - 0004-5756, 0004-5756 KW - Aflatoxins KW - 0 KW - Cottonseed Oil KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay KW - Chromatography, Thin Layer KW - Cottonseed Oil -- analysis KW - Aflatoxins -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78915344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Enzyme-linked+immunosorbent+assay+for+screening+aflatoxin+B1+in+cottonseed+products+and+mixed+feed%3A+collaborative+study.&rft.au=Park%2C+D+L%3BMiller%2C+B+M%3BHart%2C+L+P%3BYang%2C+G%3BMcVey%2C+J%3BPage%2C+S+W%3BPestka%2C+J%3BBrown%2C+L+H&rft.aulast=Park&rft.aufirst=D&rft.date=1989-03-01&rft.volume=72&rft.issue=2&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An outbreak of acute infectious nonbacterial gastroenteritis in a high school in Maryland. AN - 78913933; 2539604 AB - An outbreak of acute infectious nonbacterial gastroenteritis (AING) occurred in a high school in Maryland in 1984. Thirty-six percent of students surveyed met the case definition of gastroenteritis, as did 24 percent of school employees. Eating lunch in the cafeteria on January 30 was significantly associated with illness. After controlling for other food items consumed during the January 30 lunch, only the sandwiches were significantly associated with illness, but the source of the contamination was not identified. Four of 17 serum pairs from sick students and none of the 8 serum pairs from exposed controls (a nonsignificant difference) showed at least a 4-fold rise in antibody titre to Norwalk virus between acute- and convalescent-phase specimens. This outbreak of AING is believed to be the first to implicate epidemiologically sandwiches as vehicles of transmission. The outbreak highlights the need for investigators to look for a viral etiology in gastroenteritis outbreaks. JF - Public health reports (Washington, D.C. : 1974) AU - Gross, T P AU - Conde, J G AU - Gary, G W AU - Harting, D AU - Goeller, D AU - Israel, E AD - Food and Drug Administration, Rockville, MD 20857. PY - 1989 SP - 164 EP - 169 VL - 104 IS - 2 SN - 0033-3549, 0033-3549 KW - Antibodies, Viral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Schools KW - Sanitation KW - Sex Factors KW - Epidemiologic Methods KW - Humans KW - Adult KW - Norwalk virus -- immunology KW - Maryland KW - Adolescent KW - Male KW - Food Services KW - Female KW - Antibodies, Viral -- biosynthesis KW - Food Microbiology KW - Virus Diseases -- transmission KW - Disease Outbreaks KW - Gastroenteritis -- transmission KW - Gastroenteritis -- epidemiology KW - Virus Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78913933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=An+outbreak+of+acute+infectious+nonbacterial+gastroenteritis+in+a+high+school+in+Maryland.&rft.au=Gross%2C+T+P%3BConde%2C+J+G%3BGary%2C+G+W%3BHarting%2C+D%3BGoeller%2C+D%3BIsrael%2C+E&rft.aulast=Gross&rft.aufirst=T&rft.date=1989-03-01&rft.volume=104&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pediatr. 1978 Dec;93(6):922-6 [214535] Lancet. 1979 May 5;1(8123):964-6 [87627] J Clin Pathol. 1979 Aug;32(8):786-93 [229128] Med J Aust. 1979 Oct 6;2(7):329-33 [514174] Am J Epidemiol. 1982 Feb;115(2):163-72 [6277184] Am J Epidemiol. 1982 Feb;115(2):173-7 [6277185] Am J Epidemiol. 1982 Feb;115(2):178-84 [6277186] J Hyg (Lond). 1982 Apr;88(2):285-93 [6278017] Am J Epidemiol. 1982 Mar;115(3):348-51 [6278928] Ann Intern Med. 1982 Jun;96(6 Pt 1):756-61 [6283977] Am J Epidemiol. 1982 Dec;116(6):940-8 [6293306] Br Med J (Clin Res Ed). 1983 Aug 27;287(6392):575-7 [6309316] Am J Public Health. 1984 Mar;74(3):263-5 [6320684] Ann Intern Med. 1984 Apr;100(4):519-21 [6322631] Microbiol Rev. 1984 Jun;48(2):157-79 [6330511] Am J Epidemiol. 1985 Feb;121(2):259-68 [2990197] N Engl J Med. 1986 Mar 13;314(11):678-81 [3005857] Am J Epidemiol. 1986 Jul;124(1):120-6 [3013001] Am J Public Health. 1987 Mar;77(3):291-5 [3028187] Am J Epidemiol. 1969 Apr;89(4):384-92 [5778927] J Infect Dis. 1969 Jun;119(6):666-8 [5795108] J Infect Dis. 1975 Jul;132(1):28-34 [1151121] J Clin Pathol. 1977 Oct;30(10):948-52 [201670] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of the orientation of nitro substituent on the bacterial mutagenicity of dinitrobenzo[e]pyrenes. AN - 78906132; 2648138 JF - Mutation research AU - Fu, P P AU - Ni, Y C AU - Zhang, Y M AU - Heflich, R H AU - Wang, Y K AU - Lai, J S AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 121 EP - 125 VL - 225 IS - 3 SN - 0027-5107, 0027-5107 KW - Benzopyrenes KW - 0 KW - Nitro Compounds KW - Index Medicus KW - Mutagenicity Tests KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - In Vitro Techniques KW - Salmonella typhimurium -- drug effects KW - Structure-Activity Relationship KW - Nitro Compounds -- toxicity KW - Benzopyrenes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78906132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Effect+of+the+orientation+of+nitro+substituent+on+the+bacterial+mutagenicity+of+dinitrobenzo%5Be%5Dpyrenes.&rft.au=Fu%2C+P+P%3BNi%2C+Y+C%3BZhang%2C+Y+M%3BHeflich%2C+R+H%3BWang%2C+Y+K%3BLai%2C+J+S&rft.aulast=Fu&rft.aufirst=P&rft.date=1989-03-01&rft.volume=225&rft.issue=3&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-25 N1 - Date created - 1989-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reducing knee morbidity among carpetlayers. AN - 78855102; 2916723 AB - Carpetlayers have a high prevalence of occupational knee morbidity, partly attributable to their use of the knee kicker to stretch carpet for wall-to-wall installation. While a mechanical alternative "power stretcher" is available, knee kickers are still widely used. A questionnaire survey indicated that unavailability of the mechanical stretcher at installation sites was a major factor for continued use of the knee kicker. Strategies to reduce use of the knee kicker are discussed. JF - American journal of public health AU - Tanaka, S AU - Lee, S T AU - Halperin, W E AU - Thun, M AU - Smith, A B AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 334 EP - 335 VL - 79 IS - 3 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Floors and Floorcoverings KW - Humans KW - Health Education KW - Knee Injuries -- prevention & control KW - Occupational Diseases -- etiology KW - Knee Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78855102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Reducing+knee+morbidity+among+carpetlayers.&rft.au=Tanaka%2C+S%3BLee%2C+S+T%3BHalperin%2C+W+E%3BThun%2C+M%3BSmith%2C+A+B&rft.aulast=Tanaka&rft.aufirst=S&rft.date=1989-03-01&rft.volume=79&rft.issue=3&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-23 N1 - Date created - 1989-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Ind Med. 1987 Sep;44(9):611-20 [2959311] N Engl J Med. 1982 Nov 11;307(20):1276-7 [7133063] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Safety guidelines for the andrology laboratory. AN - 78854866; 2920842 JF - Fertility and sterility AU - Schrader, S M AD - Experimental Toxicology Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 387 EP - 389 VL - 51 IS - 3 SN - 0015-0282, 0015-0282 KW - Index Medicus KW - AIDS/HIV KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Disinfection KW - Accidents, Occupational -- prevention & control KW - Hepatitis B -- prevention & control KW - Protective Clothing KW - Humans KW - Safety KW - Male KW - Protective Devices KW - Sexually Transmitted Diseases -- prevention & control KW - Laboratory Infection -- prevention & control KW - Semen -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78854866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fertility+and+sterility&rft.atitle=Safety+guidelines+for+the+andrology+laboratory.&rft.au=Schrader%2C+S+M&rft.aulast=Schrader&rft.aufirst=S&rft.date=1989-03-01&rft.volume=51&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Fertility+and+sterility&rft.issn=00150282&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-19 N1 - Date created - 1989-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Assessment of Services for Retired and Senior Citizens in Labette County (A Pilot Study). AN - 63114644; ED305115 AB - In November 1988, a study was conducted to identify factors contributing to the quality of life of retired persons in southeast Kansas. A random sample of 366 Labette County residents over 59 years of age was surveyed by mail regarding their social life, housing, income, health, and the social and economic environment in Kansas. Study findings, based on a 36.6%, response rate included the following: (1) the average age of the respondents was 71 years; (2) 76.5% were female, and 90.9% were retired; (3) when asked about their social life, 86.6% of the respondents indicated that they spent time with friends and 85.8% participated in church activities; (4) 18.5% worked part time, 3.1% worked full time, and 20.8% were interested in finding part- or full-time employment; (5) 97.5% believed that Labette Community College was doing an adequate job of meeting the needs of retired citizens; (6) respondents expressed the most interest in retirement seminars, exercises classes, and art appreciation classes; (7) about half of the respondents who lived in their own residence were concerned about maintaining it, citing finances, home repairs, and/or yard work as problems; (8) the average monthly income was $1,016; (9) overall, 96% of the respondents felt that Kansas was a good place for retirement; (10) though 56% said they had no health or physical handicaps, 75.4% regularly used prescription drugs; and (11) among the concerns identified in the survey were needs for Senior Citizens' Centers in each town, adequate transportation, low-cost housing, convenient shopping, and more activities for the elderly. The survey instrument is included. (AJL) AU - Usera, John J. AU - Martin, Jack W. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 32 KW - ERIC, Resources in Education (RIE) KW - Social Life KW - Two Year Colleges KW - Questionnaires KW - Community Attitudes KW - Housing KW - Welfare Reform KW - Quality of Life KW - Needs Assessment KW - Retirement KW - Older Adults KW - Community Surveys KW - Recreational Activities KW - Family Income KW - Social Environment KW - Medical Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63114644?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Changes in the Composition of the Health Professions Applicant Pool: 1977-1987. AN - 63025411; ED316166 AB - The report synthesizes and summarizes trends in the numbers and characteristics of persons who have applied to selected health professions schools (i.e., allopathic medicine, osteopathic medicine, dentistry, and veterinary medicine) from 1977 to 1987. It is based primarily on data made available by the professional associations of the schools and practitioners. Applicants in recent years are compared with those in earlier years to determine the extent to which the pool has changed with regard to racial/ethnic composition, gender composition, socioeconomic status of the applicants, and academic qualifications of the applicants. Trends in higher education that may be associated with some of the changes that have occurred in the health professions applicant pool are presented. Some of the findings are as follows: a general decline in applicant numbers; a decline in white male applicants and an increase in female applicants; recent applicants appear to be more affluent than applicants in earlier years; in most disciplines, declines in the applicant pool have been accompanied by a larger percentage of applicants accepted; and increasing undergraduate enrollments have not necessarily led to increased number of health professions schools applicants. Contains 4 references. (SM) Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 32 KW - ERIC, Resources in Education (RIE) KW - Veterinary Medical Education KW - Student Characteristics KW - Medical Schools KW - Higher Education KW - Osteopathy KW - Health Education KW - College Applicants KW - Dental Schools KW - Demography KW - Allied Health Occupations Education KW - Ethnic Groups KW - Enrollment Trends KW - Professional Education KW - Trend Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63025411?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Changes in the composition of the health professions applicant pool: 1977-1987 AN - 59513560; 1990-0203706 AB - Trends in the numbers and characteristics of persons who have applied to selected health professions schools; focuses on representation of women and minorities. JF - 5600 Fishers Lane, Rockville, MD 20857, March 1989. iv+28 pp. Y1 - 1989/03// PY - 1989 DA - March 1989 EP - iv+28 PB - 5600 Fishers Lane, Rockville, MD 20857 KW - United States KW - Medical profession KW - Minorities in medicine -- Statistics KW - Women in medicine -- Statistics KW - Medical education -- Integration and segregation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59513560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-03-01&rft.volume=&rft.issue=&rft.spage=iv%2B28&rft.isbn=&rft.btitle=Changes+in+the+composition+of+the+health+professions+applicant+pool%3A+1977-1987&rft.title=Changes+in+the+composition+of+the+health+professions+applicant+pool%3A+1977-1987&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - 5600 Fishers Lane, Rockville, MD 20857 N1 - Document feature - table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Products of stimulated monocytes enhance the activity of interferon-gamma. AN - 78962992; 2497195 AB - We have investigated the interaction of interferon-gamma (IFN-gamma) with monocytes or products of stimulated monocytes. We have shown that IFN-gamma does not stimulate IFN-alpha production in monocytes. Staphylococcus aureus (SAC) but not lipopolysaccharide (LPS) induced IFN-alpha secretion by monocytes. However, it was observed that supernatants of monocytes stimulated with IFN-gamma in combination with either LPS or SAC had higher levels of antiviral activity than supernatants of monocytes stimulated only with IFN-gamma. Moreover, the degree of enhancement of antiviral activity was dependent on the dose of either LPS or SAC used to stimulate the monocytes. Supernatants of monocytes stimulated with LPS or SAC enhanced the antiviral activity of IFN-gamma but not IFN-alpha. Thus, LPS- or SAC-stimulated monocytes produced a factor(s) that augmented the biological activity of IFN-gamma. To identify the factor within stimulated monocyte supernatants that was responsible for this enhancement, several monokines were added to IFN-gamma. Tumor necrosis factor (TNF) significantly increased the antiviral activity of IFN-gamma, although TNF by itself had no antiviral activity. Interleukin 1 (IL-1) or granulocyte-monocyte colony-stimulating factor (GM-CSF) did not enhance the activity of IFN-gamma. Our data indicate that the interaction between IFN-gamma and monocytes is bidirectional. Not only can IFN-gamma activate monocytes, but products of stimulated monocytes also enhance the biological activities of IFN-gamma. JF - Journal of interferon research AU - Gerrard, T L AU - Dyer, D R AU - Enterline, J C AU - Zoon, K C AD - Division of Cytokine Biology, FDA, Bethesda, MD 20892. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 115 EP - 124 VL - 9 IS - 1 SN - 0197-8357, 0197-8357 KW - Indicators and Reagents KW - 0 KW - Interferon Inducers KW - Interferon Type I KW - Lipopolysaccharides KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Interferon Type I -- secretion KW - Interferon Inducers -- pharmacology KW - Lipopolysaccharides -- pharmacology KW - Interferon Type I -- biosynthesis KW - Humans KW - Staphylococcus aureus KW - Drug Synergism KW - Cell Line KW - Monocytes -- metabolism KW - Interferon-gamma -- metabolism KW - Interferon-gamma -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78962992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+research&rft.atitle=Products+of+stimulated+monocytes+enhance+the+activity+of+interferon-gamma.&rft.au=Gerrard%2C+T+L%3BDyer%2C+D+R%3BEnterline%2C+J+C%3BZoon%2C+K+C&rft.aulast=Gerrard&rft.aufirst=T&rft.date=1989-02-01&rft.volume=9&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+research&rft.issn=01978357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantitative risk analysis for quantal reproductive and developmental effects. AN - 78941971; 2707205 AB - Animal experiments are generally conducted at higher dose levels than anticipated human dose levels in order to elicit otherwise subtle changes in reproduction or developmental effects with relatively few animals. Based on animal data, regulatory strategy generally has been to postulate a no-observed-effect level (NOEL) for toxic effects and to divide this by a safety factor, usually 100, to establish acceptable levels for humans. Various authors have discussed the shortcomings of using NOEL and have suggested the use of an estimable effect level determined from a dose-response curve fitted to bioassay data, e.g., the dose at which 1% of the animals are adversely affected, and employing some form of conservative low dose extrapolation to control risks at lower doses. In this paper, 10 sets of bioassay data on fetal mortality or anomalies were used to compare the estimated upper limits of risk estimated at the NOEL/100 and the lower 95% confidence limit estimate of the dose producing adverse effects in 1% of the embryonic implants or fetuses divided by 100 (LED01/100). The latter quantity is expected to result in a risk (proportion affected) of less than 10(-4) (1 in 10,000). The estimated upper limits of risk associated with the NOEL/100 were from 2 x 10(-4) to 6 x 10(-4) for the 10 data sets investigated. JF - Environmental health perspectives AU - Gaylor, D W AD - National Center for Toxicological Research, Jefferson, AR 72079. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 243 EP - 246 VL - 79 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Lethal Dose 50 KW - Rabbits KW - Mice KW - Female KW - Pregnancy KW - Cricetinae KW - Litter Size -- drug effects KW - Environmental Pollutants -- toxicity KW - Abnormalities, Drug-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78941971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Quantitative+risk+analysis+for+quantal+reproductive+and+developmental+effects.&rft.au=Gaylor%2C+D+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=1989-02-01&rft.volume=79&rft.issue=&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Teratology. 1973 Jun;7(3):243-52 [4807127] Toxicol Appl Pharmacol. 1979 Sep 15;50(2):241-52 [505455] J Occup Med. 1980 May;22(5):321-6 [7381612] J Am Vet Med Assoc. 1980 May 15;176(10 Spec No):1141-4 [6894293] J Toxicol Environ Health. 1983 Mar;11(3):329-36 [6341611] Fundam Appl Toxicol. 1984 Oct;4(5):854-71 [6510615] J Natl Cancer Inst. 1961 Aug;27:455-70 [13766313] Teratology. 1985 Apr;31(2):241-6 [3992492] Teratology. 1986 Dec;34(3):263-9 [3099417] Teratology. 1986 Dec;34(3):271-8 [3798363] Teratology. 1986 Dec;34(3):279-82 [3798364] Toxicol Ind Health. 1985 Dec;1(4):23-33 [3843503] Risk Anal. 1988 Mar;8(1):15-20 [3375503] Teratology. 1984 Dec;30(3):371-81 [6515563] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of lifetime sodium saccharin dosing on mice initiated with the carcinogen 2-acetylaminofluorene. AN - 78932999; 2714533 AB - Sodium saccharin has been reported to promote the development of urinary bladder tumors in rats following low doses of several carcinogens. To evaluate the generality of this effect between species, an initiation-promotion study was conducted in mice. Weanling female BALB/c mice were initiated with 200 ppm dietary 2-acetylaminofluorene for 90 days. Following a 2-week period of control diet, saccharin was administered at 0, 0.1, 0.5, 1.0, and 5.0% in the diet for the remainder of the 132-week study. An elevated incidence of persistent bladder transitional cell hyperplasia and a low incidence of urothelial and hepatocellular tumors indicated that these organs achieved an adequate dose of the initiator. However, sodium saccharin dosing did not result in an increased incidence of tumors in either the bladder or liver and is therefore not considered to be a promoter of carcinogenesis at these sites in the mouse. Furthermore, sodium saccharin exhibited a modest inhibitory effect on the rate of development of lymphomas in both initiated and noninitiated animals. Interspecies differences in the bladder tumorigenic effect of sodium saccharin and their association with differences in urinary tract physiology are discussed. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Frederick, C B AU - Dooley, K L AU - Kodell, R L AU - Sheldon, W G AU - Kadlubar, F F AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 346 EP - 357 VL - 12 IS - 2 SN - 0272-0590, 0272-0590 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Saccharin KW - FST467XS7D KW - Index Medicus KW - Animals KW - Neoplasms, Experimental -- chemically induced KW - Body Weight -- drug effects KW - Mice, Inbred C3H KW - Mice KW - Diet KW - Neoplasms, Experimental -- pathology KW - Mice, Inbred BALB C KW - Time Factors KW - Male KW - 2-Acetylaminofluorene -- toxicity KW - Saccharin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78932999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+effect+of+lifetime+sodium+saccharin+dosing+on+mice+initiated+with+the+carcinogen+2-acetylaminofluorene.&rft.au=Frederick%2C+C+B%3BDooley%2C+K+L%3BKodell%2C+R+L%3BSheldon%2C+W+G%3BKadlubar%2C+F+F&rft.aulast=Frederick&rft.aufirst=C&rft.date=1989-02-01&rft.volume=12&rft.issue=2&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of pesticide residues in food with a 6% cyanopropylphenyl capillary column. AN - 78878781; 2925828 AB - A small-diameter 6% cyanopropylphenyl column is studied for its suitability for determining pesticides in food. Repeatability and linearity are satisfactory, and the column is capable of separating residue combinations that are known not to separate on methyl silicone columns. At 150 degrees C or 130 degrees C, the column satisfactorily separates five by-products of tecnazene, a growth regulator and sprout suppressant found in potatoes, and four by-products of quintozene, a soil and seed fungicide found in peanut products. JF - Journal of chromatographic science AU - Daft, J L AD - U.S. Department of Health and Human Services, Food and Drug Administration, Kansas City, Missouri 64106. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 75 EP - 78 VL - 27 IS - 2 SN - 0021-9665, 0021-9665 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - Chromatography, Gas KW - Food Contamination -- analysis KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78878781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Determination+of+pesticide+residues+in+food+with+a+6%25+cyanopropylphenyl+capillary+column.&rft.au=Daft%2C+J+L&rft.aulast=Daft&rft.aufirst=J&rft.date=1989-02-01&rft.volume=27&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-02 N1 - Date created - 1989-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - BOOK T1 - Guidelines for prevention of transmission of human immunodeficiency virus and hepatitis B virus to health-care and public-safety workers; a response to P.L. 100-607, the Health Omnibus Programs Extension Act of 1988 T2 - Dept. of Health and Human Services. DHHS (NIOSH) pubn. no. 89-107 AN - 59520506; 1990-0108716 AB - Overview of the modes of transmitting HIV HBV in the workplace and specific risk-control recommendations for employers and workers. JF - Publications, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, February 1989. 46 pp. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 46 PB - Publications, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226 KW - Hepatitis KW - Immune deficiency diseases -- United States KW - Public health workers -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59520506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Education&rft.issn=00189359&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Publications, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226; Supt Docs U.S. $2.50; elsewhere $3.13 N1 - Document feature - table(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Report of the National Commission on Orphan Diseases AN - 59509942; 1989-1201964 AB - Assesses the activities of the private and public sector in connection with the various aspects of rare diseases. Partial contents: Meeting patients' needs; Research; Product development and coordination with research. JF - Washington, DC 20201, February 1989. xx+106 pp. Y1 - 1989/02// PY - 1989 DA - February 1989 EP - xx+106 PB - Washington, DC 20201 KW - United States KW - Medical research KW - Diseases KW - Pharmaceutical research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59509942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-02-01&rft.volume=&rft.issue=&rft.spage=xx%2B106&rft.isbn=&rft.btitle=Report+of+the+National+Commission+on+Orphan+Diseases&rft.title=Report+of+the+National+Commission+on+Orphan+Diseases&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Washington, DC 20201 pa N1 - Document feature - table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Site-specific oxidative DNA damage at polyguanosines produced by copper plus hydrogen peroxide. AN - 78850873; 2912981 AB - Oxidative DNA damage has been implicated in diverse biological processes including mutagenesis, carcinogenesis, aging, radiation effects, and chemotherapy. We examined the in vitro effect of low concentrations of Cu(II) or H2O2 alone and in combination on supercoiled plasmid DNA. As much as 10(-2) M Cu(II) or 10(-2) M H2O2 alone did not break the DNA. However, a mixture of 10(-6) M Cu(II) plus 10(-5) M H2O2 produced strand breaks and inactivated transforming ability. Strand breakage was proportional to incubation time, temperature, and Cu(II) and H2O2 concentrations. Abasic sites were not detected. Strand breakage was inhibited by metal chelators, catalase, and by high levels of free radical scavengers implying that Cu(II), Cu(I), H2O2, and .OH were involved in the reaction. The extent of DNA strand breakage was not affected by superoxide dismutase indicating that superoxide was not a major contributor to the DNA damage. DNA sequence analysis demonstrated that hot piperidine-sensitive DNA lesions were produced preferentially at sites of 2 or more adjacent guanosine residues. This sequence specificity was observed with Cu(II) plus H2O2 but not with Cu(I) alone. Polyguanosine sequence specificity for DNA damage induction appears to be unique among simple chemical systems. This reaction may be important in mechanisms of oxidative damage in vivo. JF - The Journal of biological chemistry AU - Sagripanti, J L AU - Kraemer, K H AD - Molecular Biology Branch, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989/01/25/ PY - 1989 DA - 1989 Jan 25 SP - 1729 EP - 1734 VL - 264 IS - 3 SN - 0021-9258, 0021-9258 KW - DNA, Superhelical KW - 0 KW - Guanosine KW - 12133JR80S KW - Copper KW - 789U1901C5 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - DNA, Superhelical -- drug effects KW - Base Sequence KW - Temperature KW - Superoxide Dismutase -- metabolism KW - Plasmids KW - Structure-Activity Relationship KW - DNA Damage KW - Hydrogen Peroxide -- pharmacology KW - Copper -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78850873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Site-specific+oxidative+DNA+damage+at+polyguanosines+produced+by+copper+plus+hydrogen+peroxide.&rft.au=Sagripanti%2C+J+L%3BKraemer%2C+K+H&rft.aulast=Sagripanti&rft.aufirst=J&rft.date=1989-01-25&rft.volume=264&rft.issue=3&rft.spage=1729&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-03 N1 - Date created - 1989-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - High-performance liquid chromatographic separation of ring-oxidized metabolites of nitro-polycyclic aromatic hydrocarbons. AN - 78948024; 2708476 AB - Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation to exert their biological activities. Metabolism of nitro-PAHs generates ring-oxidized metabolites including epoxides, phenols, dihydrodiols and tetrahydrotetrols. Separation of the oxidized metabolites and related compounds of a series of isomeric nitro compounds derived from anthracene, benz[a]anthracene, benzo[a]pyrene and benzo[e]pyrene was studied by high-performance liquid chromatography (HPLC) of different types of columns (monomeric and polymeric; reversed-phase and normal-phase). In the reversed-phase HPLC system, the general elution order of these compounds is: parent nitro-PAHs greater than phenolic derivatives greater than epoxides greater than dihydrodiols greater than tetrahydrotetrols. Among the geometric isomers, trans-dihydrodiols with both hydroxyl groups at the quasiaxial positions were eluted earlier than those with the hydroxyl groups at the quasiequatorial positions. Orientation of the nitro substituent has also been found to be an important structural feature for determining the relative retention order. Among the geometric isomers of nitro-PAHs and trans-dihydrodiols, the isomers with their nitro groups perpendicular or nearly perpendicular to the aromatic rings were eluted faster than the analogues with their nitro groups parallel or nearly parallel to the aromatic rings. Normal-phase HPLC gave opposite retention order, but with different separability among some of the compounds. Therefore, combination of both reversed- and normal-phase HPLC provides efficient separation of the ring-oxidized derivatives of nitro-PAHs. Results are also presented to compare the separation efficiency among different types of columns used. The results suggest that the polarity of solutes is the principal factor for determining their HPLC retention time. JF - Journal of chromatography AU - von Tungeln, L S AU - Fu, P P AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1989/01/06/ PY - 1989 DA - 1989 Jan 06 SP - 315 EP - 326 VL - 461 KW - Environmental Pollutants KW - 0 KW - Nitro Compounds KW - Polycyclic Compounds KW - Index Medicus KW - Oxidation-Reduction KW - Chemistry KW - Chemical Phenomena KW - Environmental Pollutants -- analysis KW - Chromatography, High Pressure Liquid KW - Nitro Compounds -- analysis KW - Polycyclic Compounds -- analysis KW - Polycyclic Compounds -- metabolism KW - Nitro Compounds -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78948024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography&rft.atitle=High-performance+liquid+chromatographic+separation+of+ring-oxidized+metabolites+of+nitro-polycyclic+aromatic+hydrocarbons.&rft.au=von+Tungeln%2C+L+S%3BFu%2C+P+P&rft.aulast=von+Tungeln&rft.aufirst=L&rft.date=1989-01-06&rft.volume=461&rft.issue=&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-08 N1 - Date created - 1989-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Criteria for identifying and listing substances known to cause developmental toxicity under California's Proposition 65. AN - 79576305; 2520504 AB - Because of the automatic restrictions and warning requirements imposed on substances identified by the state as "known to cause developmental toxicity," the Expert Committee recommends the use of criteria that emphasize human relevancy, biological plausibility, and evidence in support of a selective, adverse developmental effect at non-maternally-toxic doses. In many instances, data for substances of public concern will be insufficient at present to meet these criteria. The fact that a substance is not listed as "known to cause developmental toxicity" does not create a presumption that the substance is safe. The Expert Committee, therefore, urges that these substances be recommended for further testing and that high priority be given to conducting the necessary tests. The Expert Committee reiterates its concern that substances listed by the SAP be identified according to the toxic endpoints (cancer, male reproductive toxicity, female reproductive toxicity, and/or developmental toxicity) that led to listing. Further, the Expert Committee recommends that the state Health and Welfare Agency institute education programs emphasizing appropriate courses of action for citizens informed of exposures to substances known to the state to cause cancer, birth defects, or reproductive toxicity. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Mattison, D R AU - Hanson, J W AU - Kochhar, D M AU - Rao, K S AD - Division of Human Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 3 EP - 12 VL - 3 IS - 1 SN - 0890-6238, 0890-6238 KW - Carcinogens KW - 0 KW - Hazardous Waste KW - Teratogens KW - Index Medicus KW - California KW - Animals KW - Humans KW - Carcinogens -- toxicity KW - Hazardous Waste -- legislation & jurisprudence KW - Legislation, Medical -- trends KW - Teratogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79576305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Criteria+for+identifying+and+listing+substances+known+to+cause+developmental+toxicity+under+California%27s+Proposition+65.&rft.au=Mattison%2C+D+R%3BHanson%2C+J+W%3BKochhar%2C+D+M%3BRao%2C+K+S&rft.aulast=Mattison&rft.aufirst=D&rft.date=1989-01-01&rft.volume=3&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-12 N1 - Date created - 1992-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Reprod Toxicol. 1991;5(3):169-73; discussion 175-8 [1807551] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatocellular foci--a regulator's Gordian. AN - 79484690; 2629105 AB - Recently, the Food and Drug Administration has received several petitions which raise the question of the significance of an increased number of treated rats with foci of hepatocellular alteration. Study pathologists are responsible for defining the diagnostic criteria used in any study to diagnose proliferative changes in the liver. Similarly, study pathologists, based on their observations of the overall liver findings, are responsible for assessing the biological significance of any lesion observed and including their appraisal in the written pathology narrative which should accompany any petition sent to a regulatory agency. Current scientific knowledge regarding the incidence of animals with foci of cellular alteration suggests that the historical control incidence of animals with this change is somewhat less than is currently being observed. While some foci of cellular alteration may progress to neoplastic lesions, it is not possible to unequivocally predict whether carcinogenic activity may be demonstrated, based only on the incidence of animals with foci of cellular alteration. The Food and Drug Administration, for the foreseeable future, will continue to examine the incidence of animals with selected proliferative liver lesions, including foci of cellular alteration, on a case by case basis. JF - Toxicologic pathology AU - Moch, R W AU - O'Neill, T P AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989 PY - 1989 DA - 1989 SP - 724 EP - 728 VL - 17 IS - 4 Pt 1 SN - 0192-6233, 0192-6233 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Carcinogenicity Tests KW - Liver -- ultrastructure KW - Liver -- pathology KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- chemically induced KW - Legislation, Medical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79484690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Hepatocellular+foci--a+regulator%27s+Gordian.&rft.au=Moch%2C+R+W%3BO%27Neill%2C+T+P&rft.aulast=Moch&rft.aufirst=R&rft.date=1989-01-01&rft.volume=17&rft.issue=4+Pt+1&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-13 N1 - Date created - 1990-04-13 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Chronic prenatal haloperidol exposure: lack of effect on presynaptic dopamine autoreceptors. AN - 79483713; 2516618 AB - Prenatal haloperidol exposure in rats is known to reduce striatal D2 receptor binding in postnatal day (PND) 30 offspring. The effects of prenatal haloperidol exposure on presynaptic dopamine (DA) autoreceptor function are not well described. Pregnant albino rats were given daily injections of haloperidol (2.5 or 5.0 mg/kg, sc) or vehicle over gestational days 6-20. Presynaptic DA autoreceptor function was assessed using the DOPA decarboxylase inhibitor NSD-1015 and gamma-butyrolactone in the caudate, nucleus accumbens and olfactory tubercles of male offspring sacrificed on PND 97. There appeared to be no impairment of autoreceptor function in any region studied. The data indicate that prenatal haloperidol exposure does not result in permanent alterations in presynaptic DA autoreceptor function. JF - Neurotoxicology AU - Scalzo, F M AU - Newport, G D AU - Gough, B J AU - Ali, S F AU - Holson, R R AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 485 EP - 490 VL - 10 IS - 3 SN - 0161-813X, 0161-813X KW - Hydrazines KW - 0 KW - Receptors, Dopamine KW - Dihydroxyphenylalanine KW - 63-84-3 KW - 3-hydroxybenzylhydrazine KW - A27K5Q85R2 KW - Haloperidol KW - J6292F8L3D KW - Apomorphine KW - N21FAR7B4S KW - 4-Butyrolactone KW - OL659KIY4X KW - Index Medicus KW - Animals KW - Caudate Nucleus -- metabolism KW - Synapses -- drug effects KW - Nucleus Accumbens -- drug effects KW - Apomorphine -- pharmacology KW - Brain Chemistry -- drug effects KW - Olfactory Bulb -- drug effects KW - Caudate Nucleus -- drug effects KW - Chromatography, High Pressure Liquid KW - Pregnancy KW - Rats, Inbred Strains KW - Rats KW - Hydrazines -- pharmacology KW - Dihydroxyphenylalanine -- metabolism KW - Nucleus Accumbens -- metabolism KW - 4-Butyrolactone -- pharmacology KW - Olfactory Bulb -- metabolism KW - Female KW - Receptors, Dopamine -- drug effects KW - Haloperidol -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79483713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Chronic+prenatal+haloperidol+exposure%3A+lack+of+effect+on+presynaptic+dopamine+autoreceptors.&rft.au=Scalzo%2C+F+M%3BNewport%2C+G+D%3BGough%2C+B+J%3BAli%2C+S+F%3BHolson%2C+R+R&rft.aulast=Scalzo&rft.aufirst=F&rft.date=1989-01-01&rft.volume=10&rft.issue=3&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prenatal radiation risk to the brain. AN - 79482101; 2696898 AB - The Central Nervous System (CNS) exhibits a high sensitivity to ionizing radiation from conception until after birth. X-irradiation damage of the nervous system during development has been well documented and exposure to ionizing radiation above approximately 10 cGy during perinatal development is contraindicated. Shielding of the embryo or fetus usually prevents gross malformations but high energy irradiation of the pregnant female may result in embryonic growth retardation. This may be especially true when the irradiation is coupled with an ethanol-induced reduction in SOD activity. The synergistic interactions between other drugs and ionizing radiation also have been demonstrated. However, the concentration of endogenous compounds such as histamine and serotonin may be increased in the maternal circulation following irradiation and reach the fetal CNS through a blood-brain-barrier that is more permiable than normal. The introduction of histamine and/or serotonin into the fetal circulation may result in fetal hypotension, edema, cerebral ischemia, and damage to the developing CNS. JF - Neurotoxicology AU - Cockerham, L G AU - Prell, G D AD - National Center for Toxicological Research Associated Universities, University of Arkansas for Medical Sciences, Little Rock 72205-7122. Y1 - 1989 PY - 1989 DA - 1989 SP - 467 EP - 474 VL - 10 IS - 3 SN - 0161-813X, 0161-813X KW - Index Medicus KW - Animals KW - Radiation Injuries, Experimental KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Fetus -- radiation effects KW - Brain -- radiation effects KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79482101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Prenatal+radiation+risk+to+the+brain.&rft.au=Cockerham%2C+L+G%3BPrell%2C+G+D&rft.aulast=Cockerham&rft.aufirst=L&rft.date=1989-01-01&rft.volume=10&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate. AN - 79480598; 2576304 AB - MDMA (methylenedioxymethamphetamine) is a recreational drug of abuse known as "Ecstasy" which markedly decreases regional brain serotonin (5-HT) content and produces 5-HT nerve terminal degeneration in forebrain areas of the rat. In order to determine the acute and chronic behavioral effects of MDMA, adult rats were given MDMA at 0, 5 or 10 mg/kg, po for 4 consecutive days. Alternatively, parachloroamphetamine (PCA) at 5 mg/kg was administered under the same regimen. Within 30 min after the first dose, the MDMA-treated rats exhibited the serotonin motor syndrome consisting of straub tail and splayed hindlimbs comparable to that seen in the PCA-treated rats. This serotonin motor syndrome, with a duration of about 2 hr, was less pronounced after subsequent doses. At 2-4 wk after the last dose, no significant differences between control and treated rats were seen in emergence, hot plate response, auditory startle response or complex maze behavior even though a significant dose-related decrease (50%) in 5-HT concentration was observed in the frontal cortex and hippocampus of these rats 4 wks after the last dose. Adult female monkeys dosed po with 5 or 10 mg/kg of MDMA twice/day for 4 consecutive days demonstrated no spontaneous behavioral changes or weight loss compared to controls, but forebrain 5-HT concentration was reduced by 80% 1 mon after dosing. These data indicate that at doses only 2-3 times the human dose, MDMA produces significant forebrain 5-HT decreases but does not produce detectable residual behavioral alterations as assessed by these behavioral paradigms. JF - Neurotoxicology AU - Slikker, W AU - Holson, R R AU - Ali, S F AU - Kolta, M G AU - Paule, M G AU - Scallet, A C AU - McMillan, D E AU - Bailey, J R AU - Hong, J S AU - Scalzo, F M AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 529 EP - 542 VL - 10 IS - 3 SN - 0161-813X, 0161-813X KW - Amphetamines KW - 0 KW - Biogenic Monoamines KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - beta-Endorphin KW - 60617-12-1 KW - p-Chloroamphetamine KW - 64-12-0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Reaction Time -- drug effects KW - Reflex, Startle -- drug effects KW - Sex Factors KW - Biogenic Monoamines -- metabolism KW - Radioimmunoassay KW - p-Chloroamphetamine -- toxicity KW - Rats KW - Rats, Inbred Strains KW - beta-Endorphin -- metabolism KW - Macaca mulatta KW - Female KW - Male KW - Behavior, Animal -- drug effects KW - Brain Chemistry -- drug effects KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - 3,4-Methylenedioxyamphetamine -- toxicity KW - Amphetamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79480598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Behavioral+and+neurochemical+effects+of+orally+administered+MDMA+in+the+rodent+and+nonhuman+primate.&rft.au=Slikker%2C+W%3BHolson%2C+R+R%3BAli%2C+S+F%3BKolta%2C+M+G%3BPaule%2C+M+G%3BScallet%2C+A+C%3BMcMillan%2C+D+E%3BBailey%2C+J+R%3BHong%2C+J+S%3BScalzo%2C+F+M&rft.aulast=Slikker&rft.aufirst=W&rft.date=1989-01-01&rft.volume=10&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of chronic delta-9-tetrahydrocannabinol (THC) administration on neurotransmitter concentrations and receptor binding in the rat brain. AN - 79479158; 2576303 AB - THC is the major psychoactive constituent of marijuana and is also known as an hallucinogenic compound. Numerous reports have shown that large doses of THC produce significant alterations in various neurotransmitter systems. The present study was designed to determine whether chronic exposure to THC produces significant alterations in selected neurotransmitter systems (dopamine, serotonin, acetylcholine, GABAergic, benzodiazepine, and opiate) in the rat brain. In Experiment 1, male Sprague-Dawley rats were gavaged with vehicle, 10 or 20 mg THC/kg body weight daily, 5 days/week for 90 days. Animals were killed either 24 hours or two months after the last dose. Brains were dissected into different regions for neurochemical analyses. Two months after the cessation of chronic administration, there was a significant decrease in GABA receptor binding in the hippocampus of animals in the high dose group. However, no other significant changes were found in neurotransmitter receptor binding characteristics in the hippocampus or in neurotransmitter concentrations in the caudate nucleus, hypothalamus or septum after chronic THC administration. In an attempt to replicate the GABA receptor binding changes and also to determine the [35S]TBPS binding in hippocampus, we designed Experiment 2. In this experiment, we dosed the animals by gavage with 0, 5, 10 or 20 mg THC/kg daily, 5 days/week or with 20 mg THC/kg Monday through Thursday and 60 mg/kg on Friday for 90 days. Results from this experiment failed to replicate the dose-dependent effect of THC on GABA receptor binding in hippocampus. Modulation of [35S]TBPS binding by GABA or 3 alpha-OH-DHP or inhibition by cold TBPS in frontal cortex did not show any significant dose-related effects. Results from these experiments suggest that chronic exposure to THC does not produce significant alterations in catecholamine or indoleamine neurotransmitter systems or in opiate or GABA receptor systems in the rat brain. JF - Neurotoxicology AU - Ali, S F AU - Newport, G D AU - Scallet, A C AU - Gee, K W AU - Paule, M G AU - Brown, R M AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 491 EP - 500 VL - 10 IS - 3 SN - 0161-813X, 0161-813X KW - Nerve Tissue Proteins KW - 0 KW - Neurotransmitter Agents KW - Receptors, Neurotransmitter KW - Sulfur Radioisotopes KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Animals KW - Cerebral Cortex -- drug effects KW - Caudate Nucleus -- metabolism KW - Cerebral Cortex -- metabolism KW - Hypothalamus -- drug effects KW - Hippocampus -- metabolism KW - Caudate Nucleus -- drug effects KW - Hippocampus -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Hypothalamus -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Male KW - Neurotransmitter Agents -- metabolism KW - Brain Chemistry -- drug effects KW - Dronabinol -- toxicity KW - Receptors, Neurotransmitter -- drug effects KW - Dronabinol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79479158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Effects+of+chronic+delta-9-tetrahydrocannabinol+%28THC%29+administration+on+neurotransmitter+concentrations+and+receptor+binding+in+the+rat+brain.&rft.au=Ali%2C+S+F%3BNewport%2C+G+D%3BScallet%2C+A+C%3BGee%2C+K+W%3BPaule%2C+M+G%3BBrown%2C+R+M%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1989-01-01&rft.volume=10&rft.issue=3&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brain. AN - 79479105; 2576301 AB - Phencyclidine is a widely used drug of abuse and is known to produce a wide variety of psychoactive effects. PCP abuse by pregnant women has been reported to result in the birth of infants exhibiting irritability, jitteriness and hyperactivity with high pitched cries. The present study was designed to evaluate the distribution of PCP in the maternal and fetal brain and the neurochemical effects produced by gestational exposure. Pregnant Sprague-Dawley rats were treated sc with 5 mg/kg PCP on 3 consecutive days (GD 9-11, 12-14, 15-16, or 18-20). On gestational day (GD) 21 all rats were killed by decapitation and maternal and fetal blood was collected for PCP analysis. Brains were dissected from dams and fetuses for PCP and neurochemical analyses. On GD 21 after exposure on GD 18-20, the fetal: maternal ratio of brain PCP concentrations was 11:1. PCP exposure on GD 12-14, 15-17, and 18-20 significantly decreased fetal brain PCP binding sites on GD 21, whereas maternal values were unchanged. Fetal dopaminergic and muscarinic cholinergic receptor binding and neurotransmitter concentrations were unaffected by prenatal PCP exposure. These data demonstrated that maternal PCP exposure resulted in prolonged exposure of the developing CNS and also indicated that gestational exposure to PCP decreased high affinity binding sites of PCP in term fetal brain. JF - Neurotoxicology AU - Ali, S F AU - Ahmad, G AU - Slikker, W AU - Bondy, S C AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 383 EP - 392 VL - 10 IS - 3 SN - 0161-813X, 0161-813X KW - Nerve Tissue Proteins KW - 0 KW - Neurotransmitter Agents KW - Receptors, Muscarinic KW - Receptors, Neurotransmitter KW - Receptors, Phencyclidine KW - Spiperone KW - 4X6E73CJ0Q KW - Quinuclidinyl Benzilate KW - 6581-06-2 KW - Phencyclidine KW - J1DOI7UV76 KW - Index Medicus KW - Animals KW - Receptors, Neurotransmitter -- metabolism KW - Gestational Age KW - Pregnancy KW - Rats KW - Rats, Inbred Strains KW - Neurotransmitter Agents -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Receptors, Muscarinic -- drug effects KW - Female KW - Phencyclidine -- pharmacokinetics KW - Phencyclidine -- toxicity KW - Phencyclidine -- metabolism KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Fetus -- physiology KW - Pregnancy, Animal -- drug effects KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79479105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Effects+of+gestational+exposure+to+phencyclidine%3A+distribution+and+neurochemical+alterations+in+maternal+and+fetal+brain.&rft.au=Ali%2C+S+F%3BAhmad%2C+G%3BSlikker%2C+W%3BBondy%2C+S+C&rft.aulast=Ali&rft.aufirst=S&rft.date=1989-01-01&rft.volume=10&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Benzodiazepine-like behavioral effects following withdrawal from chronic delta-9-tetrahydrocannabinol administration in rats. AN - 79478722; 2576305 AB - Chronic exposure to cannabis extract or delta-9-tetrahydrocannabinol (THC) has been reported to produce hippocampal neuropathology in rats, as well as classical "hippocampal" behavioral deficits. In an attempt to replicate and extend these findings, male rats were exposed to THC for 13 consecutive weeks, beginning in early adolescence. Drugs were administered five consecutive days a week (Monday through Friday). There were five dose levels: vehicle control, 5, 10, or 20 mg/kg, p.o., and 20 mg/kg THC four days a week (Monday-Thursday), followed by 60 mg/kg on Friday. Following THC exposure, all animals were withdrawn from drugs for seven weeks prior to behavioral testing. Three behavioral tasks previously shown to be sensitive to hippocampal damage were assessed. These were habituation of open-field activity, 24-hr passive avoidance response retention, and complex maze performance. A fourth task, emergence latency, was also included because it has been determined to be sensitive to "anxiety" levels. To facilitate interpretation of the complex maze data, two additional experiments are also reported. One experiment tested rats exposed to trimethyltin (TMT, a potent hippocampal neurotoxicant) on the complex maze. The second assessed the affects of chronic/acute benzodiazepine (BZ) exposure upon maze performance. Test results did not suggest that chronic THC exposure produced behavioral deficits resembling those seen following hippocampal damage. Habituation rates in an activity monitor were identical for all exposure groups, and there was no passive avoidance retention deficit. Further, while TMT caused pronounced abnormalities in the complex maze, chronic THC exposure at the two highest dose levels significantly improved maze performance, similar to BZ effects on this task. Chronic THC also appeared to reduce freezing on the emergence task, another anxiolytic-like effect. These results support other reports of persistent long-term behavioral effects of chronic THC exposure. However, they suggest that some behavioral effects may more closely resemble the effects of minor tranquilizers rather than hippocampal damage. JF - Neurotoxicology AU - Holson, R R AU - Ali, S F AU - Scallet, A C AU - Slikker, W AU - Paule, M G AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 605 EP - 619 VL - 10 IS - 3 SN - 0161-813X, 0161-813X KW - Anti-Anxiety Agents KW - 0 KW - Trimethyltin Compounds KW - Benzodiazepines KW - 12794-10-4 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Body Weight -- drug effects KW - Learning -- drug effects KW - Motor Activity -- drug effects KW - Avoidance Learning -- drug effects KW - Trimethyltin Compounds -- toxicity KW - Female KW - Behavior, Animal -- drug effects KW - Anti-Anxiety Agents -- pharmacology KW - Substance Withdrawal Syndrome -- psychology KW - Dronabinol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79478722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Benzodiazepine-like+behavioral+effects+following+withdrawal+from+chronic+delta-9-tetrahydrocannabinol+administration+in+rats.&rft.au=Holson%2C+R+R%3BAli%2C+S+F%3BScallet%2C+A+C%3BSlikker%2C+W%3BPaule%2C+M+G&rft.aulast=Holson&rft.aufirst=R&rft.date=1989-01-01&rft.volume=10&rft.issue=3&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-12 N1 - Date created - 1990-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The necessity and utility of abuse liability evaluations in human subjects: the FDA perspective. AN - 79369731; 2512503 JF - NIDA research monograph AU - Vocci, F J AD - Division of Neuropharmacological Drug Products, Office of Drug Evaluation I, Food and Drug Administration, Rockville, Maryland 20857. Y1 - 1989 PY - 1989 DA - 1989 SP - 7 EP - 20 VL - 92 SN - 1046-9516, 1046-9516 KW - Street Drugs KW - 0 KW - Index Medicus KW - United States KW - Drug Evaluation KW - Animals KW - Humans KW - Drug Evaluation, Preclinical KW - United States Food and Drug Administration KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79369731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=The+necessity+and+utility+of+abuse+liability+evaluations+in+human+subjects%3A+the+FDA+perspective.&rft.au=Vocci%2C+F+J&rft.aulast=Vocci&rft.aufirst=F&rft.date=1989-01-01&rft.volume=92&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-23 N1 - Date created - 1990-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clozapine in China: a review and preview of US/PRC collaboration. AN - 79306706; 2682733 JF - Psychopharmacology AU - Potter, W Z AU - Ko, G N AU - Zhang, L D AU - Yan, W W AD - Department of Health and Human Services, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1989 PY - 1989 DA - 1989 SP - S87 EP - S91 VL - 99 Suppl SN - 0033-3158, 0033-3158 KW - Dibenzazepines KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Chlorpromazine KW - U42B7VYA4P KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - United States KW - Homovanillic Acid -- blood KW - Randomized Controlled Trials as Topic KW - Psychiatric Status Rating Scales KW - International Cooperation KW - Double-Blind Method KW - Humans KW - Adult KW - Chlorpromazine -- therapeutic use KW - Middle Aged KW - Male KW - Female KW - China KW - Clozapine -- therapeutic use KW - Schizophrenia -- drug therapy KW - Clozapine -- adverse effects KW - Dibenzazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79306706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Clozapine+in+China%3A+a+review+and+preview+of+US%2FPRC+collaboration.&rft.au=Potter%2C+W+Z%3BKo%2C+G+N%3BZhang%2C+L+D%3BYan%2C+W+W&rft.aulast=Potter&rft.aufirst=W&rft.date=1989-01-01&rft.volume=99+Suppl&rft.issue=&rft.spage=S87&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer. Cancer and Steroid Hormone Study Group. AN - 79289706; 2681548 AB - Although the important influence of a woman's reproductive history on her risk of breast cancer is widely recognized, it is not clear whether this is wholly accounted for by the age at her first full-term pregnancy, or whether there are additional, independent influences of breastfeeding or number of children. To examine the respective contributions to the risk of breast cancer of these reproductive factors, we used logistic regression methods to analyze data from a multicenter case-control study, the Cancer and Steroid Hormone Study. Included in the analysis were 4599 women, 20-55 years of age, identified as having an initial diagnosis of breast cancer by one of eight collaborating population-based cancer registries. The 4536 controls were women of similar ages selected by random dialing of households with telephones in the same eight areas. As expected, age at first full-term pregnancy exerted a strong influence on the risk of breast cancer. However, after it and other potentially confounding factors had been controlled for, parity and duration of breastfeeding also had a strong influence on the risk of breast cancer. Compared with women of parity one, women of parity seven or greater had an adjusted relative risk of breast cancer of 0.59 (95% CL, 0.44-0.79). Compared with parous women who never breastfed, women who had breastfed for 25 months or more had an adjusted relative risk of 0.67 (0.52-0.85). These results do not support the supposed preeminent importance of age at first full-term pregnancy among the reproductive determinants of breast carcinogenesis. Resolution of this issue may have important implications for elucidating hormonal influences on breast cancer and for projecting future trends in the disease. JF - Journal of clinical epidemiology AU - Layde, P M AU - Webster, L A AU - Baughman, A L AU - Wingo, P A AU - Rubin, G L AU - Ory, H W AD - U.S. Department of Health and Human Services, Centers for Disease Control, Atlanta, GA 30333. Y1 - 1989 PY - 1989 DA - 1989 SP - 963 EP - 973 VL - 42 IS - 10 SN - 0895-4356, 0895-4356 KW - Index Medicus KW - Risk KW - Multicenter Studies as Topic KW - Odds Ratio KW - Humans KW - Adult KW - Case-Control Studies KW - Interviews as Topic KW - Data Interpretation, Statistical KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Female KW - Parity KW - Breast Feeding KW - Maternal Age KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79289706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=The+independent+associations+of+parity%2C+age+at+first+full+term+pregnancy%2C+and+duration+of+breastfeeding+with+the+risk+of+breast+cancer.+Cancer+and+Steroid+Hormone+Study+Group.&rft.au=Layde%2C+P+M%3BWebster%2C+L+A%3BBaughman%2C+A+L%3BWingo%2C+P+A%3BRubin%2C+G+L%3BOry%2C+H+W&rft.aulast=Layde&rft.aufirst=P&rft.date=1989-01-01&rft.volume=42&rft.issue=10&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-30 N1 - Date created - 1989-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - "Hope in another direction": compensation for work-related illness among women, 1900-1960--Part II. AN - 79220009; 2528860 AB - This article examines compensation for work-related illness among women in the first sixty years of the twentieth century. Its first part (Vol. 15, No. 1) discussed women's experience in the employers' liability system and their workers' compensation claims for poisonings. Part II in this issue examines compensation for infectious diseases, principally tuberculosis; litigation involving lung disease produced by beryllium and asbestos; and women's workers' compensation claims for illnesses involving a mental component. JF - Women & health AU - Bale, A AD - Yale Center for Mental Health Services Research, New Haven, CT 06519. Y1 - 1989 PY - 1989 DA - 1989 SP - 99 EP - 115 VL - 15 IS - 2 SN - 0363-0242, 0363-0242 KW - Index Medicus KW - History of medicine KW - United States KW - History, 20th Century KW - Humans KW - Female KW - Women, Working KW - Occupational Diseases -- economics KW - Women KW - Workers' Compensation -- history KW - Occupational Diseases -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79220009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+%26+health&rft.atitle=%22Hope+in+another+direction%22%3A+compensation+for+work-related+illness+among+women%2C+1900-1960--Part+II.&rft.au=Bale%2C+A&rft.aulast=Bale&rft.aufirst=A&rft.date=1989-01-01&rft.volume=15&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Women+%26+health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-26 N1 - Date created - 1989-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuropathy target esterase in hens after sarin and soman. AN - 79184435; 2769693 AB - To estimate the potential of small doses of sarin (types I and II) and soman to cause delayed neuropathic effects, 400, 200, 61, and 0 micrograms/kg of sarin-I, 280, 140, 70, and 0 micrograms/kg of sarin-II, and 14.2, 7.1, 3.5, and 0 micrograms/kg of soman by gavage were compared with 510 mg/kg tri-o-cresyl phosphate (TOCP) in 14- to 18-month-old SPF white leghorn hens (4/dose) protected with atropine (100 mg/kg). The neuropathy target esterase (NTE) activity 24 hr after dosing was determined in brain, spinal cord, and lymphocytes and in plasma and brain for cholinesterase and carboxylesterase. None of the compounds showed statistically significant NTE decreases. Sarin-II showed a dose-related trend in the lymphocyte NTE (to 33% of control at 280 micrograms/kg), suggesting that longer exposure to lower doses might cause a cumulative neurotoxic insult. All of the agents decreased the activity of plasma and brain cholinesterase and carboxylesterase. Using more than 70% inhibition of brain NTE as a biochemical predictor of delayed neuropathy, sarin and soman appear unable to cause delayed neuropathy at nonlethal doses within this protocol. JF - Journal of biochemical toxicology AU - Crowell, J A AU - Parker, R M AU - Bucci, T J AU - Dacre, J C AD - Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 15 EP - 20 VL - 4 IS - 1 SN - 0887-2082, 0887-2082 KW - Organophosphorus Compounds KW - 0 KW - Tritolyl Phosphates KW - Soman KW - 96-64-0 KW - Sarin KW - B4XG72QGFM KW - Esterases KW - EC 3.1.- KW - tri-o-cresyl phosphate KW - X8II18JD0A KW - Index Medicus KW - Animals KW - Tritolyl Phosphates -- toxicity KW - Dose-Response Relationship, Drug KW - Female KW - Chickens -- physiology KW - Nervous System Diseases -- enzymology KW - Esterases -- metabolism KW - Soman -- toxicity KW - Organophosphorus Compounds -- toxicity KW - Sarin -- toxicity KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79184435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+toxicology&rft.atitle=Neuropathy+target+esterase+in+hens+after+sarin+and+soman.&rft.au=Crowell%2C+J+A%3BParker%2C+R+M%3BBucci%2C+T+J%3BDacre%2C+J+C&rft.aulast=Crowell&rft.aufirst=J&rft.date=1989-01-01&rft.volume=4&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+toxicology&rft.issn=08872082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-05 N1 - Date created - 1989-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Flow cytometric analysis of bromodeoxyuridine-induced inhibition of cell proliferation in the human teratocarcinoma-derived cell line, P3. AN - 79172562; 2767057 AB - We have developed methods in our laboratory whereby the effects of toxicant exposure on cell proliferation can be evaluated flow cytometrically. We sought to relate the flow cytometric analyses to other biological response measurements. Thus, we exposed P3 cells to increasing concentrations of bromodeoxyuridine (BRdU) and measured sister-chromatid exchange (SCE) frequency, average generation time (AGT), and relative cloning ability. Each of these is well documented (see introduction) to respond to BRdU exposure in a concentration-dependent manner. In this study, SCE frequency remained constant between the concentrations of 2.5 and 10 microM of BRdU. However, a small, but significant, increase in SCE frequency was observed between the concentrations of 10 microM and 50 microM BRdU. A significant increase in AGT was noted in 50 microM BRdU-exposed cells. Relative cloning efficiency decreased in a concentration-dependent manner when cells were cultured for 24, 48, or 72 hours with BRdU. When cell proliferation was assessed by flow cytometric analysis in cells exposed to 0, 10, or 50 microM BRdU, a statistically significant delay in the cell-cycle was observed in BRdU-exposed cells. These results may be interpreted to mean that inhibition of cell proliferation is detected by this type of analysis at toxicant concentrations that induce other biological endpoints. The inclusion of flow cytometric analysis in a test battery to evaluate toxicant effects is warranted. JF - Environmental and molecular mutagenesis AU - Morris, S M AU - McGarrity, L J AU - Domon, O E AU - Hinson, W G AU - Kodell, R L AD - Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 107 EP - 114 VL - 14 IS - 2 SN - 0893-6692, 0893-6692 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Tumor Cells, Cultured -- drug effects KW - Teratoma -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - Tumor Stem Cell Assay KW - Bromodeoxyuridine -- pharmacology KW - Sister Chromatid Exchange -- drug effects KW - Cell Division -- drug effects KW - Flow Cytometry KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79172562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Flow+cytometric+analysis+of+bromodeoxyuridine-induced+inhibition+of+cell+proliferation+in+the+human+teratocarcinoma-derived+cell+line%2C+P3.&rft.au=Morris%2C+S+M%3BMcGarrity%2C+L+J%3BDomon%2C+O+E%3BHinson%2C+W+G%3BKodell%2C+R+L&rft.aulast=Morris&rft.aufirst=S&rft.date=1989-01-01&rft.volume=14&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-10 N1 - Date created - 1989-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenicity of some alkyl nitrites used as recreational drugs. AN - 79170405; 2569972 AB - When the AIDS epidemic was in its earliest stages, and prior to identification of HIV as the etiological factor, the use of volatile nitrites by the male homosexual community to enhance sexual activities appeared to have a significant role in this disease. Preliminary observations indicated that the portion of the male homosexual community which developed Kaposi's sarcoma were also heavy nitrite users. These nitrites had been demonstrated to be mutagenic in bacteria and thus it was postulated that they could be responsible for the appearance of the sarcoma. To evaluate further the genotoxic activity of these chemicals, six nitrites, including those most commonly used by homosexuals for sexual gratification, were selected for testing in the mouse lymphoma TK+/- and Salmonella typhimurium mutagenicity assays. One chemical, n-amyl nitrite, was negative in the mouse lymphoma assay, while the other five chemicals, n-butyl, isobutyl, iso-amyl, sec-butyl, and n-propyl nitrite, were positive. All six compounds were positive in the Salmonella assay. The mutagenic and known toxic effects of these chemicals remain a concern because a large population of teenagers and young adults continue to abuse these substances. JF - Environmental and molecular mutagenesis AU - Dunkel, V C AU - Rogers-Back, A M AU - Lawlor, T E AU - Harbell, J W AU - Cameron, T P AD - Food and Drug Administration, Washington, DC. Y1 - 1989 PY - 1989 DA - 1989 SP - 115 EP - 122 VL - 14 IS - 2 SN - 0893-6692, 0893-6692 KW - Aphrodisiacs KW - 0 KW - Nitrites KW - Street Drugs KW - Amyl Nitrite KW - 8017-89-8 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Rats KW - Aphrodisiacs -- pharmacology KW - Animals KW - Mutagenicity Tests KW - Mice KW - Leukemia L5178 KW - Male KW - Female KW - Thymidine Kinase -- genetics KW - Nitrites -- pharmacology KW - Street Drugs -- pharmacology KW - Tumor Cells, Cultured -- drug effects KW - Salmonella typhimurium -- drug effects KW - Amyl Nitrite -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79170405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Mutagenicity+of+some+alkyl+nitrites+used+as+recreational+drugs.&rft.au=Dunkel%2C+V+C%3BRogers-Back%2C+A+M%3BLawlor%2C+T+E%3BHarbell%2C+J+W%3BCameron%2C+T+P&rft.aulast=Dunkel&rft.aufirst=V&rft.date=1989-01-01&rft.volume=14&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-10 N1 - Date created - 1989-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Haloperidol- and SCH23390-induced dopaminergic supersensitivities are not additive in the rat. AN - 79132925; 2569216 AB - The effect of chronic D-1 and/or D-2 dopamine receptor blockade on apomorphine-induced behaviors was studied in rats treated for 21 days with the selective D-1 antagonist SCH23390, the predominantly D-2 antagonist haloperidol, and the combination of the two drugs at the same daily doses (0.1 and 1 mg/kg respectively). Apomorphine (0.3 mg/kg) 4 days following the last injection of the drugs increased (49-70%) stereotypic behavior in all animals as compared to saline-treated controls. Although the SCH23390-induced increase was lower than haloperidol-induced supersensitivity, stereotypies after combined administration of both drugs did not differ significantly from either, suggesting that the effects of the two drugs are not additive. Underlying receptor changes and modified D-1/D-2 receptor interactions may account for the participation of both receptor subtypes to the development of neuroleptic-induced dopaminergic supersensitivity. JF - Psychopharmacology AU - Parashos, S A AU - Barone, P AU - Marin, C A AU - Paraschos, A J AU - Kapitzoglou-Logothetis, V AU - Chase, T N AD - National Institute of Neurological and Communicative Disorders and Stroke, Department of Health and Human Services, US Public Health Service, Bethesda, MD 20892. Y1 - 1989 PY - 1989 DA - 1989 SP - 189 EP - 192 VL - 98 IS - 2 SN - 0033-3158, 0033-3158 KW - Antipsychotic Agents KW - 0 KW - Benzazepines KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Drug Interactions KW - Stereotyped Behavior -- drug effects KW - Motor Activity -- drug effects KW - Male KW - Benzazepines -- pharmacology KW - Antipsychotic Agents -- pharmacology KW - Haloperidol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79132925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Haloperidol-+and+SCH23390-induced+dopaminergic+supersensitivities+are+not+additive+in+the+rat.&rft.au=Parashos%2C+S+A%3BBarone%2C+P%3BMarin%2C+C+A%3BParaschos%2C+A+J%3BKapitzoglou-Logothetis%2C+V%3BChase%2C+T+N&rft.aulast=Parashos&rft.aufirst=S&rft.date=1989-01-01&rft.volume=98&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-29 N1 - Date created - 1989-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Demographic and seasonal influences on human serum pesticide residue levels. AN - 79130771; 2760935 AB - This study was intended to characterize more fully the distribution of serum concentrations of 16 pesticide residues with regard to key demographic and seasonal variables in a subsample of persons from the Second National Health and Nutrition Examination Survey between the ages of 12 and 74 yr old. Blood sera in 2-ml aliquots were analyzed, and the results were confirmed for 5994 persons. Almost all participants (99.5%) had p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentrations greater than or equal to 1 ppb, ranging as high as 378.6 ppb. For the other pesticide residues, only beta-benzene hexachloride (beta-BHC) (quantified in 17.2% of the sera), dieldrin (10.6%), and another DDT-related residue, p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) (35.7%) were found at quantifiable levels in more than 10% of the serum specimens. Of the remaining analytes, hexachlorobenzene (HCB), trans-nonachlor (TNC), and heptachlor epoxide (HE) were found at quantifiable concentrations in 1-10% of the specimens, whereas o,p'-DDT, o,p'-DDE, p,p'-DDD, mirex, alpha-BHC, gamma-BHC, heptachlor, delta-BHC, and aldrin were found in less than 1% of the serum specimens. Results showed that increasing age, residing on a farm, or being a male conferred increased risks of exposure to most of the pesticide residues, independent of all other demographic and seasonal factors. In a pattern less consistent across the different pesticide residues and for fewer of the pesticides, persons who lived below the national poverty level, were nonwhite, resided in the South or West, or were examined in the spring or winter also seemed to have an increased likelihood of having quantifiable serum levels. JF - Journal of toxicology and environmental health AU - Stehr-Green, P A AD - Centers for Disease Control, Department of Health and Human Services, Atlanta, Georgia 30333. Y1 - 1989 PY - 1989 DA - 1989 SP - 405 EP - 421 VL - 27 IS - 4 SN - 0098-4108, 0098-4108 KW - Pesticide Residues KW - 0 KW - Pesticides KW - Index Medicus KW - United States KW - Age Factors KW - Sex Factors KW - Humans KW - Continental Population Groups KW - Aged KW - Socioeconomic Factors KW - Adult KW - Seasons KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Pesticides -- blood KW - Demography KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79130771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Demographic+and+seasonal+influences+on+human+serum+pesticide+residue+levels.&rft.au=Stehr-Green%2C+P+A&rft.aulast=Stehr-Green&rft.aufirst=P&rft.date=1989-01-01&rft.volume=27&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-18 N1 - Date created - 1989-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - FDA procedures and policies to estimate risks of injury to the male reproductive system. AN - 79118394; 2755951 AB - Two decades ago, the Food and Drug Administration (FDA) undertook a testing and research program to study and assess the mutagenic properties of so-called "Generally Recognized as Safe" (GRAS) substances which have a long history of use in food. Initially, the program employed three highly regarded mutagenicity tests; the host mediated assay, somatic cell cytogenetics, and the dominant lethal test. Only the latter measures male germ cell events. Eventually, research and testing results revealed major problems in the deployment of these tests for such purposes. A new approach involving a three tiered system was instituted in which the first tier was a relatively inexpensive pre-screen ostensibly capable of detecting any and all potential mutagens. For reasons of economy, this pre-screen used micro-organisms. The objective of the second tier was to determine if substances positive in the first tier of tests would be mutagenic for higher organisms. Gene mutation in mammalian cells in culture, gene plus chromosomal mutation in Drosophila and heritable translocation in male mice were used for this purpose. The final tier was intended to assess the quantitative risk of mutation in mammals and depended entirely upon genetic studies in animals. Again, the heritable translocation test would be used as well as the specific locus test in mice. At the same time, efforts were made to refine and improve the usefulness of the dominant lethal and the heritable translocation test for toxicological purposes. More recently, studies have been undertaken to develop a practical test for nondisjunction in male germ cells. Currently, standard test requirements for food additive approval include only short-term in vitro mutagenicity tests.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Progress in clinical and biological research AU - Flamm, W G AU - Dunkel, V C AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989 PY - 1989 DA - 1989 SP - 21 EP - 9; discussion 30-2 VL - 302 SN - 0361-7742, 0361-7742 KW - Mutagens KW - 0 KW - Index Medicus KW - United States KW - Translocation, Genetic -- drug effects KW - Animals KW - Mutagenicity Tests KW - Risk Factors KW - Male KW - Female KW - Health Planning KW - United States Food and Drug Administration KW - Spermatozoa -- drug effects KW - Health Planning Guidelines KW - Mutagens -- toxicity KW - Health Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79118394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=FDA+procedures+and+policies+to+estimate+risks+of+injury+to+the+male+reproductive+system.&rft.au=Flamm%2C+W+G%3BDunkel%2C+V+C&rft.aulast=Flamm&rft.aufirst=W&rft.date=1989-01-01&rft.volume=302&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-29 N1 - Date created - 1989-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparative study of minoxidil-induced myocardial lesions in beagle dogs and miniature swine. AN - 79111090; 2749140 AB - Minoxidil, a long-acting vasodilating antihypertensive agent, reduces arterial blood pressure by a direct action on arteriolar smooth muscle. The present studies examined the gross anatomic, histologic and ultrastructural myocardial alterations produced by 2 daily doses of minoxidil in beagle dogs (0.5, 1, or 3 mg/kg) and miniature swine (1, 3, or 10 mg/kg). Both myocardial necroses and hemorrhages were observed in dogs and pigs 24 hr after the last dose of minoxidil. In both species, the necroses were most frequent in the left ventricular papillary muscles, particularly the posterior one, but were less severe in swine. An ischemic origin of the necroses was suggested by the location of the lesions and by the pharmacologic effects of minoxidil. Gross epicardial or endocardial hemorrhages involving the atria and, to a lesser extent, the ventricles were observed in both species but were more severe in dogs. The atrial lesions were manifested grossly by diffuse redness and microscopically by interstitial edema, extravasated erythrocytes and infiltration of mononuclear cells. Hemorrhages, occurring on the epicardial surfaces, were often associated with lesions that involved small arteries having 3-6 layers of medial smooth muscle cells and were characterized by endothelial injury, intramural accumulations of erythrocytes and platelets, periadventitial hemorrhage, fibrin deposits and an inflammatory cell reaction. These lesions preferentially involved the right atrium in dogs and the left atrium in pigs. Pretreatment of beagle dogs with pyribenzamine (3 doses of 6 mg/kg every 8 hr), cimetidine (3 doses of 15 mg/kg every 8 hr), or both, had no effect on the incidence or severity of minoxidil-induced hemorrhagic lesions. The hemorrhagic lesions may be caused by overstretching of the vascular walls due to excessive, prolonged vasodilatation. JF - Toxicologic pathology AU - Herman, E H AU - Ferrans, V J AU - Young, R S AU - Balazs, T AD - Division of Research and Testing, Food and Drug Administration, Washington, D.C. 20204. Y1 - 1989 PY - 1989 DA - 1989 SP - 182 EP - 192 VL - 17 IS - 1 Pt 2 SN - 0192-6233, 0192-6233 KW - Histamine Antagonists KW - 0 KW - Minoxidil KW - 5965120SH1 KW - Index Medicus KW - Hemodynamics -- drug effects KW - Swine KW - Animals KW - Histamine Antagonists -- pharmacology KW - Coronary Vessels -- pathology KW - Swine, Miniature KW - Heart Rate -- drug effects KW - Dogs KW - Blood Pressure -- drug effects KW - Arterioles -- pathology KW - Species Specificity KW - Female KW - Male KW - Minoxidil -- toxicity KW - Cardiomyopathies -- pathology KW - Cardiomyopathies -- physiopathology KW - Cardiomyopathies -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79111090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=A+comparative+study+of+minoxidil-induced+myocardial+lesions+in+beagle+dogs+and+miniature+swine.&rft.au=Herman%2C+E+H%3BFerrans%2C+V+J%3BYoung%2C+R+S%3BBalazs%2C+T&rft.aulast=Herman&rft.aufirst=E&rft.date=1989-01-01&rft.volume=17&rft.issue=1+Pt+2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - "Hope in another direction": compensation for work-related illness among women, 1900-1960--Part I. AN - 79109192; 2526414 AB - This two-part article looks at women's attempts to receive compensation for their work-related illnesses in the first sixty years of the twentieth century. Women pressed claims through narrow legal remedies in the tort and workers' compensation systems for a small part of their massive burden of work-related illnesses. Part I examines the network of women advocates around occupational disease compensation; women's experience under the employers' liability and workers' compensation systems; women's most frequently compensated illnesses under workers' compensation, dermatitis and systemic poisoning; and notable litigation episodes involving phosphorus and radium poisoning. Part II of this article, to be published in the next issue, focuses on compensation for tuberculosis, asbestosis, beryllium disease, and illnesses with a mental component. JF - Women & health AU - Bale, A AD - Yale Center for Mental Health Services Research, New Haven, CT 06519. Y1 - 1989 PY - 1989 DA - 1989 SP - 81 EP - 102 VL - 15 IS - 1 SN - 0363-0242, 0363-0242 KW - Index Medicus KW - History of medicine KW - United States KW - History, 20th Century KW - Humans KW - Legislation, Medical KW - Female KW - Women, Working KW - Women KW - Workers' Compensation -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79109192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+%26+health&rft.atitle=%22Hope+in+another+direction%22%3A+compensation+for+work-related+illness+among+women%2C+1900-1960--Part+I.&rft.au=Bale%2C+A&rft.aulast=Bale&rft.aufirst=A&rft.date=1989-01-01&rft.volume=15&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Women+%26+health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-22 N1 - Date created - 1989-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pretreatment with mixed-function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay. AN - 79069576; 2737181 AB - A recent National Toxicology Program evaluation indicates that the rat hepatocyte/DNA repair assay has a high false-negative rate and that it is insensitive to some genotoxic hepatocarcinogens as well as other species and organ-specific carcinogens. In this study, we examined whether the sensitivity of the hepatocyte/DNA repair assay might be increased through animal pretreatment with various hepatic mixed-function oxidase inducers, i.e., Aroclor 1254, phenobarbital, and 3,3',4,4'-tetrachloroazobenzene (TCAB). The effects on unscheduled DNA synthesis (UDS), a measure of DNA damage and repair, were studied in cultures exposed to known and/or potential carcinogens that had been evaluated as negative or questionable or that produced conflicting results with hepatocytes isolated from uninduced animals. 4,4'-Oxydianiline, 1-nitropyrene, and TCAB produced concentration-dependent increases in UDS in hepatocytes from rats pretreated with Aroclor 1254. 4,4'-Oxydianiline and TCAB also induced a dose-dependent increase in DNA repair in hepatocytes from rats pretreated with phenobarbital, whereas 1-nitropyrene was negative. 4,4'-Methylenedianiline produced a marginal response, and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) was negative in Aroclor- and phenobarbital-induced hepatocytes; however, TCAOB, as well as TCAB, produced concentration-dependent increases in UDS in TCAB-induced hepatocytes. These data indicate that the limited sensitivity to chemical carcinogens displayed by the hepatocyte/DNA repair assay may be increased by using hepatocytes isolated from animals exposed to hepatic mixed-function oxidase inducers. JF - Environmental and molecular mutagenesis AU - Shaddock, J G AU - Heflich, R H AU - McMillan, D C AU - Hinson, J A AU - Casciano, D A AD - Department of Health and Human Services, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 281 EP - 288 VL - 13 IS - 4 SN - 0893-6692, 0893-6692 KW - Aroclors KW - 0 KW - Azo Compounds KW - Carcinogens KW - Chlorobenzenes KW - Mutagens KW - 3,4,3',4'-tetrachloroazobenzene KW - 14047-09-7 KW - Mixed Function Oxygenases KW - EC 1.- KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Chlorobenzenes -- pharmacology KW - Autoradiography KW - Rats, Inbred Strains KW - Rats KW - Aroclors -- pharmacology KW - Phenobarbital -- pharmacology KW - Cells, Cultured KW - Azo Compounds -- pharmacology KW - Enzyme Induction KW - Male KW - Mutagenicity Tests KW - Liver -- enzymology KW - Liver -- cytology KW - Mixed Function Oxygenases -- metabolism KW - Mixed Function Oxygenases -- biosynthesis KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79069576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Pretreatment+with+mixed-function+oxidase+inducers+increases+the+sensitivity+of+the+hepatocyte%2FDNA+repair+assay.&rft.au=Shaddock%2C+J+G%3BHeflich%2C+R+H%3BMcMillan%2C+D+C%3BHinson%2C+J+A%3BCasciano%2C+D+A&rft.aulast=Shaddock&rft.aufirst=J&rft.date=1989-01-01&rft.volume=13&rft.issue=4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-02 N1 - Date created - 1989-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evolution of social concerns and environmental policies for chemical mutagens. AN - 79040251; 2659331 AB - The founding of the Environmental Mutagen Society 20 years ago coincided with the beginning of general social concern about exposure to chemical mutagens. Initially, this concern focused on the potential of chemicals to induce heritable genetic damage in humans. Within a few years, however, mutagenicity tests came to be regarded primarily as short-term tests for carcinogenicity. Serious doubts have recently been cast upon the relationship between mutagenicity and carcinogenicity, and, as a result the real utility of mutagenicity tests is being questioned. Justification for the continued use of these tests will require 1) more detailed mechanistic knowledge concerning the role of genetic changes in the development of cancer and 2) an improved ability to relate the results of mutagenicity tests to the potential for inducing heritable genetic effects in humans. JF - Environmental and molecular mutagenesis AU - Prival, M J AU - Dellarco, V L AD - Genetic Toxicology Branch, U.S. Food and Drug Administration, Washington, DC 20204. Y1 - 1989 PY - 1989 DA - 1989 SP - 46 EP - 50 VL - 14 Suppl 16 SN - 0893-6692, 0893-6692 KW - Carcinogens, Environmental KW - 0 KW - Mutagens KW - Index Medicus KW - History of medicine KW - United States KW - History, 20th Century KW - Humans KW - Quality of Life KW - Genetics, Medical -- history KW - Public Policy KW - Mutagenicity Tests -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79040251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Evolution+of+social+concerns+and+environmental+policies+for+chemical+mutagens.&rft.au=Prival%2C+M+J%3BDellarco%2C+V+L&rft.aulast=Prival&rft.aufirst=M&rft.date=1989-01-01&rft.volume=14+Suppl+16&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-21 N1 - Date created - 1989-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Variability of selected nutrients and contaminants monitored in rodent diets: a 6-year study. AN - 79021633; 2724367 AB - The results are given from monitoring a commercial closed-formula cereal-based rodent diet (Purina 5010), two open-formula cereal-based diets (NIH-31 and NIH-07), and one purified diet (AIN-76) for selected nutrients and contaminants. The observed concentrations of nutrients (protein, fat, vitamin A, and thiamine) approximated the manufacturer specifications for closed-formula cereal diet, while the average concentrations of nutrients found in the open-formula cereal diets were well above the nominal concentrations. Nominal concentrations for these open-formula diets tended to be close to the minimum values that were observed. Except for protein levels, greater variation in nutrient concentrations was found in the purified diet than in the cereal diets, but the variation of contaminants was about equal in the two types of diets. Open- and closed-formula cereal diets appear to be very similar to each other in the degree of variation of nutrients and contaminants. Cadmium, lead, and selenium are the constituents of greatest concern in assuring the quality of the rodent diets that were evaluated. JF - Journal of toxicology and environmental health AU - Oller, W L AU - Kendall, D C AU - Greenman, D L AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 47 EP - 56 VL - 27 IS - 1 SN - 0098-4108, 0098-4108 KW - Index Medicus KW - Rats KW - Animals KW - Nutritive Value KW - Food Contamination -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79021633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Variability+of+selected+nutrients+and+contaminants+monitored+in+rodent+diets%3A+a+6-year+study.&rft.au=Oller%2C+W+L%3BKendall%2C+D+C%3BGreenman%2C+D+L&rft.aulast=Oller&rft.aufirst=W&rft.date=1989-01-01&rft.volume=27&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A poisonous plant file in TOXLINE. AN - 78996049; 2655182 AB - A file has been added to TOXLINE on the subject of the toxicology of poisonous plants. It contains 2508 records, each of which comprises the full reference, key words, Chemical Abstracts Service Registry Number and abstract when available. A controlled vocabulary was constructed for the indexing and can be obtained from the National Technical Information Service. Searches can be made for several different data elements including authors; year; significant textwords of the title or abstract; journal or book; document type such as review or case report; geographic place at the level of continent, nation and state/province; plant species at the level of family, genus and species; plant parts involved; animal species affected including humans; type of harmful effects including major signs and lesions and chemicals. JF - Toxicon : official journal of the International Society on Toxinology AU - Wagstaff, D J AU - Wagstaff, A T AU - Goshorn, J C AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1989 PY - 1989 DA - 1989 SP - 259 EP - 263 VL - 27 IS - 2 SN - 0041-0101, 0041-0101 KW - Index Medicus KW - United States KW - Information Systems KW - Plants, Toxic KW - MEDLARS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78996049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=A+poisonous+plant+file+in+TOXLINE.&rft.au=Wagstaff%2C+D+J%3BWagstaff%2C+A+T%3BGoshorn%2C+J+C&rft.aulast=Wagstaff&rft.aufirst=D&rft.date=1989-01-01&rft.volume=27&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Smokeless tobacco use in the United States: the adult use of tobacco surveys. AN - 78988206; 2785647 AB - Prevalence of smokeless tobacco use is reported for adults aged 21 years and older in the Adult Use of Tobacco Surveys, 1964-1986. Data from the 1986 survey on prevalence, beliefs, ages of initiation, and demographic correlates of use by males aged 17 years and older are also reported. The prevalence of smokeless tobacco use declined slightly among persons aged 21 and older between 1966 and 1986. However, 5.2% of the males aged 17 and older used smokeless tobacco in 1986, and prevalence was highest among those 17 to 19 years old (8.2%). The median age of initiation for both products was 19 years. Smokeless tobacco use was most common among white men who were 1) living in the southeastern United States, 2) unemployed, and 3) in blue-collar or service/labor employment. Most users (77.4%) and nonusers (83.4%) believe that smokeless tobacco is a health hazard. Many current users (39.1%) had attempted to quit. Some current (6.4%) and former smokers (7.0%) have used smokeless tobacco as an aid to smoking cessation. National survey data such as these permit the identification of high-risk groups, so that interventions against smokeless tobacco use may be specifically targeted. JF - NCI monographs : a publication of the National Cancer Institute AU - Novotny, T E AU - Pierce, J P AU - Fiore, M C AU - Davis, R M AD - Centers for Disease Control, Department of Health and Human Services, Rockville, Maryland 20857. Y1 - 1989 PY - 1989 DA - 1989 SP - 25 EP - 28 IS - 8 SN - 0893-2751, 0893-2751 KW - Index Medicus KW - United States KW - Socioeconomic Factors KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Plants, Toxic KW - Tobacco Use Disorder -- epidemiology KW - Tobacco KW - Tobacco, Smokeless UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78988206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=Smokeless+tobacco+use+in+the+United+States%3A+the+adult+use+of+tobacco+surveys.&rft.au=Novotny%2C+T+E%3BPierce%2C+J+P%3BFiore%2C+M+C%3BDavis%2C+R+M&rft.aulast=Novotny&rft.aufirst=T&rft.date=1989-01-01&rft.volume=&rft.issue=8&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radionuclides in domestic and imported foods in the United States, 1983-1986. AN - 78982930; 2715131 AB - Findings in the Food and Drug Administration's Radionuclides in Foods program are summarized for samples collected between October 1, 1982, and September 30, 1986. All radionuclide findings for Total Diet and reactor samples were either in Action Range I or low in Range II of the surveillance and control recommendations given by the Federal Radiation Council. The only long-range trend noted was a continuation of the general decline in dietary intake of 90Sr since 1961. Imported food samples were analyzed for contamination after the Chernobyl nuclear accident. The findings for imported foods indicate that the surveillance efforts successfully targeted contaminated foods, and that contamination levels were below levels of concern for all but one oregano and 3 cheese samples. JF - Journal - Association of Official Analytical Chemists AU - Cunningham, W C AU - Stroube, W B AU - Baratta, E J AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 15 EP - 18 VL - 72 IS - 1 SN - 0004-5756, 0004-5756 KW - Radioisotopes KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Diet KW - Time Factors KW - Food Contamination, Radioactive -- analysis KW - Radioisotopes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78982930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Radionuclides+in+domestic+and+imported+foods+in+the+United+States%2C+1983-1986.&rft.au=Cunningham%2C+W+C%3BStroube%2C+W+B%3BBaratta%2C+E+J&rft.aulast=Cunningham&rft.aufirst=W&rft.date=1989-01-01&rft.volume=72&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-13 N1 - Date created - 1989-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Multistrain experiments for screening toxic substances. AN - 78961817; 2709435 AB - The advantages of using homogeneous experimental groups (inbred animal strains) and of using multiple groups within an experiment, based on the power of the Mantel-Haenszel test, were investigated. A simulation experiment was performed to empirically calculate the power of a one-sided Mantel-Haenszel test for multistrain experiments. In each case, the power of the multistrain experiment was compared to the (empirical) expected value, over strains, of the power where each strain is tested individually. In the simulation, use of subgroups, each having different response rates, resulted in an increase in power where a chemical exposure caused an average increase of effects in 10% or more of the animals across strains. JF - Journal of toxicology and environmental health AU - Felton, R P AU - Gaylor, D W AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 399 EP - 411 VL - 26 IS - 4 SN - 0098-4108, 0098-4108 KW - Index Medicus KW - Animals KW - Statistics as Topic KW - Research Design KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78961817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Multistrain+experiments+for+screening+toxic+substances.&rft.au=Felton%2C+R+P%3BGaylor%2C+D+W&rft.aulast=Felton&rft.aufirst=R&rft.date=1989-01-01&rft.volume=26&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of nitroreduction in the synergistic mutational response induced by mixtures of 1- and 3-nitrobenzo[a]pyrene in Salmonella typhimurium. AN - 78951775; 2651117 AB - Previous studies showed that binary mixtures of the environmental pollutants 1- and 3-nitrobenzo[a]pyrene produced a synergistic mutational response in the Salmonella reversion assay. Since nitroreduction is believed to mediate the direct-acting mutagenicity of the individual compounds, we have examined the role of nitroreduction in the mutagenicity of mixtures of 1- and 3-nitrobenzo[a]pyrene in the Salmonella plate incorporation assay. While mixtures of 1- and 3-nitrobenzo[a]pyrene induced up to 183% more revertants in strain TA98 than produced by equivalent amounts of the individual compounds, in the nitroreductase-deficient strain TA98NR the same mixtures only induced up to 57% more revertants than the individual compounds. Analysis of mixtures of 1- and 3-nitrosobenzo[a]pyrene (the two-electron reduction products of 1- and 3-nitrobenzo[a]pyrene) for mutation induction in TA98 yielded no evidence of a synergistic effect between the compounds. The mutagenicity of the mixtures was dependent upon the amount of the more mutagenic component. Salmonella cultures were also incubated with mixtures of 1- and 3-nitrobenzo[a]pyrene, as well as with equivalent amounts of the individual compounds. In two experiments, nitroreductive ability, as measured by the amount of 1-nitropyrene metabolized to 1-aminopyrene in 1 hr, was increased 9 to 105% in cultures pretreated with the mixtures as compared with cultures pretreated with the individual compounds. The results of this study support the hypothesis that nitroreduction is a major factor in the synergistic mutational response induced by 1- and 3-nitrobenzo[a]pyrene in Salmonella typhimurium. JF - Environmental and molecular mutagenesis AU - Thornton-Manning, J R AU - Campbell, W L AU - Hass, B S AU - Chen, J J AU - Fu, P P AU - Cerniglia, C E AU - Heflich, R H AD - National Center for Toxicological Research, Jefferson, AK 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 203 EP - 210 VL - 13 IS - 3 SN - 0893-6692, 0893-6692 KW - Benzopyrenes KW - 0 KW - 3-nitrobenzo(a)pyrene KW - 70021-98-6 KW - 1-nitrobenzo(a)pyrene KW - 70021-99-7 KW - Oxidoreductases KW - EC 1.- KW - Nitroreductases KW - EC 1.7.- KW - Index Medicus KW - Mutagenicity Tests KW - Drug Synergism KW - Oxidoreductases -- metabolism KW - Nitroreductases -- metabolism KW - Benzopyrenes -- pharmacology KW - Salmonella typhimurium -- drug effects KW - Salmonella typhimurium -- enzymology KW - Nitroreductases -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78951775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Role+of+nitroreduction+in+the+synergistic+mutational+response+induced+by+mixtures+of+1-+and+3-nitrobenzo%5Ba%5Dpyrene+in+Salmonella+typhimurium.&rft.au=Thornton-Manning%2C+J+R%3BCampbell%2C+W+L%3BHass%2C+B+S%3BChen%2C+J+J%3BFu%2C+P+P%3BCerniglia%2C+C+E%3BHeflich%2C+R+H&rft.aulast=Thornton-Manning&rft.aufirst=J&rft.date=1989-01-01&rft.volume=13&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-08 N1 - Date created - 1989-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Saccharin. AN - 78946948; 2653753 AB - Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on several occasions during this century. Over this period, the substance has come to be regarded as a useful commodity in the dietary management of diabetes mellitus. We review the historical and scientific background on the subject and propose a new approach in making public-health decisions on unique foods that serve a special dietary purpose. JF - Diabetes care AU - Miller, S A AU - Frattali, V P AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 74 EP - 80 VL - 12 IS - 1 SN - 0149-5992, 0149-5992 KW - Carcinogens KW - 0 KW - Saccharin KW - FST467XS7D KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Legislation, Drug KW - Diet, Diabetic KW - Saccharin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78946948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Saccharin.&rft.au=Miller%2C+S+A%3BFrattali%2C+V+P&rft.aulast=Miller&rft.aufirst=S&rft.date=1989-01-01&rft.volume=12&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Limited survey of deoxynivalenol in wheat and corn in the United States. AN - 78939788; 2715134 AB - A limited survey was conducted over a 2-year period to determine the incidence and levels of deoxynivalenol (DON) in corn and wheat grown in selected areas of the United States. Samples of corn (198) and wheat (247) were collected and analyzed by a gas chromatographic method. Sixty-six percent of the corn samples collected in 1984 and 30% of the corn samples collected in 1985 contained DON. The average concentration of DON in corn, by state, ranged from 0.11 to 1.20 micrograms/g; the maximum concentration was 2.47 micrograms/g. Only 2 of the 247 samples of wheat contained DON at a concentration greater than 2 micrograms/g, which is the level of concern suggested by the Food and Drug Administration for wheat entering the milling process for human consumption. JF - Journal - Association of Official Analytical Chemists AU - Wood, G E AU - Carter, L AD - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204. PY - 1989 SP - 38 EP - 40 VL - 72 IS - 1 SN - 0004-5756, 0004-5756 KW - Sesquiterpenes KW - 0 KW - Trichothecenes KW - deoxynivalenol KW - JT37HYP23V KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Trichothecenes -- analysis KW - Sesquiterpenes -- analysis KW - Zea mays -- analysis KW - Triticum -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78939788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Limited+survey+of+deoxynivalenol+in+wheat+and+corn+in+the+United+States.&rft.au=Wood%2C+G+E%3BCarter%2C+L&rft.aulast=Wood&rft.aufirst=G&rft.date=1989-01-01&rft.volume=72&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-13 N1 - Date created - 1989-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Residual ethylene oxide determination in polymethyl methacrylate disks and intraocular lenses by headspace gas analysis and N,N-dimethylformamide extraction. AN - 78915427; 2709317 AB - The residue in an ethylene oxide (EO)-exposed polymethyl methacrylate (PMMA) material [flat disk and intraocular lens (IOL)] was determined using three methods: semiautomatic and manual headspace methods and N,N-dimethylformamide (DMF) solvent extraction. Results from the analysis of three different sample configurations at three different EO concentrations are compared. Results from the DMF extraction of PMMA indicate that the headspace methods at 100 degrees C are not exhaustive with respect to recovery of total residual ethylene oxide. Furthermore, the manual headspace method appears to be slightly more effective than the semiautomatic injection headspace method. Sorption of EO and subsequent extraction is related to the surface area-to-volume ratio of the sample, with higher concentrations observed in samples with the high ratio. JF - Journal of pharmaceutical sciences AU - Lao, N T AU - Rajan, R R AU - Bushar, H F AD - Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 40 EP - 43 VL - 78 IS - 1 SN - 0022-3549, 0022-3549 KW - Methylmethacrylates KW - 0 KW - Dimethylformamide KW - 8696NH0Y2X KW - Ethylene Oxide KW - JJH7GNN18P KW - Index Medicus KW - Methylmethacrylates -- analysis KW - Chromatography, Gas KW - Drug Residues -- analysis KW - Chemistry, Physical KW - Chemical Phenomena KW - Autoanalysis KW - Lenses, Intraocular KW - Ethylene Oxide -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78915427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Residual+ethylene+oxide+determination+in+polymethyl+methacrylate+disks+and+intraocular+lenses+by+headspace+gas+analysis+and+N%2CN-dimethylformamide+extraction.&rft.au=Lao%2C+N+T%3BRajan%2C+R+R%3BBushar%2C+H+F&rft.aulast=Lao&rft.aufirst=N&rft.date=1989-01-01&rft.volume=78&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Triethyllead-induced peroxidative damage in various regions of the rat brain. AN - 78886512; 2537905 AB - Adult male Fisher 344 rats (8-10 wk old) were dosed ip with 1.75 mg/kg body weight of triethyllead chloride (TEL) for 5 consecutive days. Rats were sacrificed 1, 7, or 21 d after the last injection. The rate of lipid peroxidation was significantly elevated in frontal cortex at all three time points assayed (1, 7, or 21 d). However, hippocampal and cerebellar membranes showed no changes in peroxidative capacity at these time points. In order to determine whether cortical membrane damage was reflected in alteration of a restricted protein population, a series of high-affinity receptor binding sites was determined in cortical membranes derived from treated rats 7 d after the last injection of triethyllead. The rate of lipid peroxidation was significantly increased in the frontal cortex of triethyllead treated rats; however, no changes in the binding of [3H]spiroperidol, [3H]quinuclidinyl benzilate, and [3H]benzodiazepine were seen in animals exposed to triethyllead. The cortical wet weight, protein content, and cell number were also unchanged by TEL treatment, reflecting an absence of gross damage. JF - Journal of toxicology and environmental health AU - Ali, S F AU - Bondy, S C AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989 PY - 1989 DA - 1989 SP - 235 EP - 242 VL - 26 IS - 2 SN - 0098-4108, 0098-4108 KW - Organometallic Compounds KW - 0 KW - Receptors, Neurotransmitter KW - Lead KW - 2P299V784P KW - triethyllead KW - 660G77BZ3J KW - Index Medicus KW - Rats KW - Injections, Intraperitoneal KW - Animals KW - Rats, Inbred F344 KW - Cerebral Cortex -- metabolism KW - Male KW - Receptors, Neurotransmitter -- metabolism KW - Lead -- toxicity KW - Brain -- drug effects KW - Lipid Peroxidation -- drug effects KW - Brain -- metabolism KW - Organometallic Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78886512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Triethyllead-induced+peroxidative+damage+in+various+regions+of+the+rat+brain.&rft.au=Ali%2C+S+F%3BBondy%2C+S+C&rft.aulast=Ali&rft.aufirst=S&rft.date=1989-01-01&rft.volume=26&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-20 N1 - Date created - 1989-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epitope characterization of acetaminophen bound to protein and nonprotein sulfhydryl groups by an enzyme-linked immunosorbent assay. AN - 78848401; 2464056 AB - The oxidation of acetaminophen to N-acetyl-p-benzoquinone imine and its subsequent binding to protein sulfhydryl groups may be important in the observed toxicity of acetaminophen. An avidin biotin-amplified competitive enzyme-linked immunosorbent assay has been developed which utilizes solid phase acetaminophen bound to metallothionein and antiserum obtained from rabbits that were immunized with 3-(N-acetyl-L-cystein-S-yl)acetaminophen covalently bound to keyhole-limpet hemocyanin. Over 25 synthetic analogs of acetaminophen conjugates and structurally similar compounds have been ranked relative to their ability to compete in the avidin biotin-amplified enzyme-linked immunosorbent assay. The most effective inhibitor was 3-(N-acetyl-L-cystein-S-yl)acetaminophen, which had an observed 50% inhibitory concentration of 120 fmol/well. Approximately 6200-fold higher concentrations of unbound acetaminophen and 5.2 x 10(6)-fold higher concentrations of N-acetyl-L-cysteine were required for comparable inhibition. It was demonstrated with acetaminophen analogs that the hydroxyl group and the N-acetyl moiety of acetaminophen were important in epitope recognition. A 5000-fold decrease in detection was observed when the analog did not contain the hydroxyl group or when the N-acetyl moiety was replaced with a hydroxyl substituent. Recognition by antibody was also dependent upon the stereochemistry of the analogs. The 50% inhibitory concentration for 3-(L-cystein-S-yl)acetaminophen was 2300 fmol/well, whereas a 25-fold higher concentration of 3-(D-cystein-S-yl)acetaminophen was required for 50% inhibition.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Potter, D W AU - Pumford, N R AU - Hinson, J A AU - Benson, R W AU - Roberts, D W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 182 EP - 189 VL - 248 IS - 1 SN - 0022-3565, 0022-3565 KW - Epitopes KW - 0 KW - Sulfhydryl Compounds KW - Acetaminophen KW - 362O9ITL9D KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Animals KW - Enzyme-Linked Immunosorbent Assay KW - Rabbits KW - Protein Binding KW - Metallothionein -- metabolism KW - Structure-Activity Relationship KW - Epitopes -- analysis KW - Sulfhydryl Compounds -- metabolism KW - Acetaminophen -- immunology KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78848401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Epitope+characterization+of+acetaminophen+bound+to+protein+and+nonprotein+sulfhydryl+groups+by+an+enzyme-linked+immunosorbent+assay.&rft.au=Potter%2C+D+W%3BPumford%2C+N+R%3BHinson%2C+J+A%3BBenson%2C+R+W%3BRoberts%2C+D+W&rft.aulast=Potter&rft.aufirst=D&rft.date=1989-01-01&rft.volume=248&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-03 N1 - Date created - 1989-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reevaluation of the mutagenicity and carcinogenicity of chemicals previously identified as "false positives" in the Salmonella typhimurium mutagenicity assay. AN - 78846654; 2642804 AB - An accurate determination of the correlation between the carcinogenicity and the mutagenicity of chemicals has been hampered by the lack of a well-documented list of noncarcinogens. To overcome this problem, Shelby and Stasiewicz (Environ Mutagen 6:871-878, 1984) published a list of 70 chemicals that showed no evidence of carcinogenicity in the National Cancer Institute (NCI) or National Toxicology Program (NTP) rodent carcinogenesis bioassays. More recently, Tennant et al. (Science 236:933-941, 1987) published a list of chemicals, including 29 noncarcinogens, that had been adequately tested for carcinogenicity by the NTP. Of the chemicals listed by Shelby and Stasiewicz or by Tennant and co-workers as noncarcinogenic, the NTP has evaluated 25 as mutagenic in Salmonella typhimurium; 48 of the noncarcinogens were evaluated as nonmutagenic. Thus, of the 73 noncarcinogens that have been evaluated as either positive or negative for mutagenicity, 34% (25/73) were "false positives" (mutagenic noncarcinogens) in the S. typhimurium assay. We re-evaluated the same mutagenicity and carcinogenicity data to determine whether the frequency of "false positives" is really as high as it appears to be. Our reevaluation of the mutagenicity data used more stringent criteria for calling a compound mutagenic than those used by the NTP, resulting in a substantial reduction in the frequency of "false positives" in the S. typhimurium mutagenicity assay. However, application of these same stringent criteria also substantially reduced the frequency of "true positives" (mutagenic carcinogens). Thus, it is concluded that modification of the evaluation criteria for the mutagenicity test can increase the specificity of the assay for the detection of carcinogens, but only at the cost of a corresponding reduction in sensitivity. We also performed a separate reevaluation of the NCI/NTP carcinogenicity data for the 25 S. typhimurium "false positives," assuming that the NTP evaluations of the mutagenicity data were correct. These reevaluations were based on the methodologies and findings of Griesemer and Cueto (In Montesano R, Bartsch H, Tomatis L (eds): Molecular and Cellular Aspects of Carcinogen Screening Tests.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Environmental and molecular mutagenesis AU - Prival, M J AU - Dunkel, V C AD - Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204. Y1 - 1989 PY - 1989 DA - 1989 SP - 1 EP - 24 VL - 13 IS - 1 SN - 0893-6692, 0893-6692 KW - Index Medicus KW - Salmonella typhimurium KW - False Positive Reactions KW - Mutagenicity Tests KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78846654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Reevaluation+of+the+mutagenicity+and+carcinogenicity+of+chemicals+previously+identified+as+%22false+positives%22+in+the+Salmonella+typhimurium+mutagenicity+assay.&rft.au=Prival%2C+M+J%3BDunkel%2C+V+C&rft.aulast=Prival&rft.aufirst=M&rft.date=1989-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-23 N1 - Date created - 1989-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Embryo-maternal distribution of basic compounds in the CD-1 mouse: doxylamine and nicotine. AN - 78846499; 2916231 AB - The intracellular pH of the early postimplantation rodent embryo (pHi) is alkaline with respect to the corresponding plasma of the pregnant dam. This transplacental pH gradient is of considerable importance in the accumulation of teratogenic weak acids by the embryo. The importance of pH in the partitioning of basic drugs across the early mammalian placenta has not been investigated. Theoretically, the maternal plasma should retain a higher concentration of basic drugs than the embryo due to a greater degree of drug ionization in the more acidic plasma. To explore the significance of pH partitioning upon the transplacental distribution of basic compounds, two bases, doxylamine and nicotine, were administered to pregnant CD-1 mice during early organogenesis. The maternal plasma and embryonic concentrations of the bases were measured and the resulting embryo/maternal plasma (E/P) ratio was calculated and compared to the ratio predicted by the Henderson-Hasselbalch equation. Following ip injection of nicotine on Day 9 of gestation, the E/P ratio was significantly greater than the predicted ratio 10 min after injection and continued to rise for 3 hr. For doxylamine succinate administered by oral gavage on Day 9 or 10, the E/P ratio was also significantly greater than the ratio predicted from the pH gradient. Our results indicate that the partitioning of these basic compounds between the maternal plasma and the early postimplantation rodent embryo is not a consequence of the pH gradient between the two compartments alone. JF - Toxicology and applied pharmacology AU - Roberts, L G AU - Luck, W AU - Holder, C L AU - Scott, W J AU - Nau, H AU - Slikker, W AD - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 134 EP - 140 VL - 97 IS - 1 SN - 0041-008X, 0041-008X KW - Pyridines KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Doxylamine KW - 95QB77JKPL KW - doxylamine succinate KW - V9BI9B5YI2 KW - Index Medicus KW - Animals KW - Hydrogen-Ion Concentration KW - Muscles -- metabolism KW - Biological Transport KW - Mice KW - Mice, Inbred Strains -- embryology KW - Embryo, Mammalian -- metabolism KW - Time Factors KW - Female KW - Pregnancy KW - Maternal-Fetal Exchange KW - Doxylamine -- pharmacokinetics KW - Nicotine -- pharmacokinetics KW - Pyridines -- pharmacokinetics KW - Nicotine -- blood KW - Doxylamine -- analogs & derivatives KW - Doxylamine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78846499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Embryo-maternal+distribution+of+basic+compounds+in+the+CD-1+mouse%3A+doxylamine+and+nicotine.&rft.au=Roberts%2C+L+G%3BLuck%2C+W%3BHolder%2C+C+L%3BScott%2C+W+J%3BNau%2C+H%3BSlikker%2C+W&rft.aulast=Roberts&rft.aufirst=L&rft.date=1989-01-01&rft.volume=97&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-23 N1 - Date created - 1989-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preclinical and pharmacology and toxicology of hematopoietic growth factors. AN - 78841757; 14542822 AB - Initial evaluation of the safety of biological products, whether manufactured by biotechnology or not, is dictated by the extent of knowledge of the biological effects in vitro, in animals, and in man at the proposed dose and duration of administration. The quantity of useful information that will be gained from an animal study is considered for each product on a case-by-case basis. This requires consideration of the availability of a relevant species. Relevance is determined by presence and relative affinity and distribution of receptors for the biological product, relative potency in induction of biological activity related to the putative mechanism of action and pharmacokinetic considerations. The impurities and immunogenic potential of the product are also considered in designing the preclinical studies. After evaluating all these factors, the residual lack of knowledge is FDA's basis for recommending specific preclinical testing. The considerations inherent in the preclinical evaluation of factors acting primarily on hematopoietic cells, erythropoietin (EPO), interleukins (IL's) and colony stimulating factors (CSF) (1) will be discussed using case examples. JF - Biotechnology advances AU - Weissinger, J AD - HFD-502, Center for Drug Evaluation and Research, FDA, Rockville, MD 20857, USA. Y1 - 1989 PY - 1989 DA - 1989 SP - 387 EP - 399 VL - 7 IS - 3 SN - 0734-9750, 0734-9750 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78841757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+advances&rft.atitle=Preclinical+and+pharmacology+and+toxicology+of+hematopoietic+growth+factors.&rft.au=Weissinger%2C+J&rft.aulast=Weissinger&rft.aufirst=J&rft.date=1989-01-01&rft.volume=7&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Biotechnology+advances&rft.issn=07349750&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-13 N1 - Date created - 2003-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sequence homology between tetanus and botulinum toxins detected by an antipeptide antibody. AN - 78840134; 2909486 AB - The extent of immunological similarity between tetanus toxin and botulinum toxins A, B, C1, and E was studied by using 10 antibodies produced against synthetic peptides representing different sequences of tetanus toxin, mouse antitetanus serum, and human Tetanus Immune Globulin. Antibodies produced against the synthetic peptides recognized tetanus toxin in an enzyme-linked immunosorbent assay and on Western blots (immunoblots) but did not appear to recognize the native protein. One of the antitetanus peptide antibodies, which was produced against a peptide from the amino terminal, cross-reacted with three of the four botulinum toxins on immunoblots. This antibody, 1, reacted strongly with botulinum toxins B and C1 and weakly with E but did not recognize type A toxin. None of the other peptide antibodies cross-reacted with the botulinum toxins. Mouse antitetanus serum and human Tetanus Immune Globulin did not recognize any of the botulinum toxins on immunoblots. The amino-terminal region of the light chain of tetanus toxin and botulinum toxin types A, B, C1, and E are known to have sequence homology. Our data demonstrate that for tetanus toxin and botulinum toxin types B, C1, and E this region also has immunological homology. Type A, which has the least amount of homology with tetanus toxin in this region, does not share this immunological homology. These data also suggest that although the native structures of tetanus and botulinum toxins have relatively few common immunological determinants, the two toxins may contain short stretches of identical or very similar amino acid sequences. JF - Infection and immunity AU - Halpern, J L AU - Smith, L A AU - Seamon, K B AU - Groover, K A AU - Habig, W H AD - Division of Bacterial Products, Food and Drug Administration, Bethesda, Maryland 20892. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 18 EP - 22 VL - 57 IS - 1 SN - 0019-9567, 0019-9567 KW - Antibodies, Bacterial KW - 0 KW - Peptides KW - Tetanus Toxin KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Immunoblotting KW - Animals KW - Molecular Sequence Data KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Amino Acid Sequence KW - Mice, Inbred BALB C KW - Binding Sites, Antibody KW - Cross Reactions KW - Tetanus Toxin -- immunology KW - Tetanus Toxin -- isolation & purification KW - Base Sequence KW - Botulinum Toxins -- immunology KW - Sequence Homology, Nucleic Acid KW - Peptides -- metabolism KW - Peptides -- immunology KW - Botulinum Toxins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78840134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Sequence+homology+between+tetanus+and+botulinum+toxins+detected+by+an+antipeptide+antibody.&rft.au=Halpern%2C+J+L%3BSmith%2C+L+A%3BSeamon%2C+K+B%3BGroover%2C+K+A%3BHabig%2C+W+H&rft.aulast=Halpern&rft.aufirst=J&rft.date=1989-01-01&rft.volume=57&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-03 N1 - Date created - 1989-02-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 1984 Jan;11(1):29-34 [6143282] J Neurosci. 1983 Nov;3(11):2310-23 [6631482] Arch Biochem Biophys. 1985 May 1;238(2):544-8 [3888113] Nature. 1985 Oct 24-30;317(6039):719-21 [3932884] J Bacteriol. 1986 Jan;165(1):21-7 [3510187] Anal Biochem. 1986 Jul;156(1):213-9 [3740411] Curr Top Microbiol Immunol. 1986;129:93-179 [3533452] Nucleic Acids Res. 1986 Oct 10;14(19):7809-12 [3774547] EMBO J. 1986 Oct;5(10):2495-502 [3536478] Infect Immun. 1987 Dec;55(12):3051-6 [2824382] J Biol Chem. 1987 Dec 25;262(36):17677-82 [3320046] Infect Immun. 1988 Apr;56(4):898-902 [2450068] J Neurochem. 1971 Sep;18(9):1751-9 [4936886] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Int J Pept Protein Res. 1987 Dec;30(6):794-800 [3440702] Nat New Biol. 1973 Aug 1;244(135):157-8 [4516379] Biochem J. 1973 Jul;133(3):529-39 [4733239] Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 [388439] Brain Res. 1981 Apr 6;210(1-2):291-9 [6164441] Mol Pharmacol. 1981 Nov;20(3):565-70 [6120449] Biochem Biophys Res Commun. 1984 Mar 30;119(3):900-4 [6370252] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice. AN - 78839401; 2913271 AB - Using a recently developed enzyme-linked immunosorbent assay specific for 3-(cystein-S-yl)acetaminophen adducts we have quantitated the formation of these specific adducts in liver and serum protein of B6C3F1 male mice dosed with acetaminophen. Administration of acetaminophen at doses of 50, 100, 200, 300, 400 and 500 mg/kg to mice resulted in evidence of hepatotoxicity (increase in serum levels of alanine aminotransferase and aspartate aminotransferase) at 4 hr in the 300, 400 and 500 mg/kg treatment groups only. The formation of 3-(cystein-S-yl)acetaminophen adducts in liver protein was not observed in the groups receiving 50, 100 and 200 mg/kg doses, but was observed in the groups receiving doses above 300 mg/kg of acetaminophen. Greater levels of adduct formation were observed at the higher doses. 3-(Cystein-S-yl)acetaminophen protein adducts were also observed in serum of mice receiving hepatotoxic doses of acetaminophen. After a 400 mg/kg dose of acetaminophen, 3-(cystein-S-yl)acetaminophen adducts in the liver protein reached peak levels 2 hr after dosing. By 12 hr the levels decreased to approximately 10% of the peak level. In contrast, 3-(cystein-S-yl)acetaminophen adducts in serum protein were delayed, reaching a sustained peak 6 to 12 hr after dosing. The dose-response correlation between the appearance of serum aminotransferases and 3-(cystein-S-yl)acetaminophen adducts in serum protein and the temporal correlation between the decrease in 3-(cystein-S-yl)acetaminophen adducts in liver protein and the appearance of adducts in serum protein are consistent with a hepatic origin of the adducts detected in serum protein.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Pumford, N R AU - Hinson, J A AU - Potter, D W AU - Rowland, K L AU - Benson, R W AU - Roberts, D W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 190 EP - 196 VL - 248 IS - 1 SN - 0022-3565, 0022-3565 KW - Blood Proteins KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Time Factors KW - Protein Binding KW - Male KW - Cysteine -- metabolism KW - Liver -- drug effects KW - Acetaminophen -- immunology KW - Liver -- metabolism KW - Blood Proteins -- metabolism KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78839401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Immunochemical+quantitation+of+3-%28cystein-S-yl%29acetaminophen+adducts+in+serum+and+liver+proteins+of+acetaminophen-treated+mice.&rft.au=Pumford%2C+N+R%3BHinson%2C+J+A%3BPotter%2C+D+W%3BRowland%2C+K+L%3BBenson%2C+R+W%3BRoberts%2C+D+W&rft.aulast=Pumford&rft.aufirst=N&rft.date=1989-01-01&rft.volume=248&rft.issue=1&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-03 N1 - Date created - 1989-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of purified altertoxins I, II, and III in the metabolic communication V79 system. AN - 78832933; 2913335 AB - Purified Alternaria alternata altertoxins I, II, and III were evaluated for comparative cytotoxicity and ability to inhibit gap junction communication in the Chinese hamster lung metabolic cooperation assay. The noncytotoxic test range for each altertoxin was determined for the metabolic communication assays: altertoxin I, 1, 2, 3, 4, 5 micrograms/ml; altertoxin II, 0.02, 0.008, 0.006, 0.004, 0.002, 0.0008 micrograms/ml; and altertoxin III, 0.2, 0.1, 0.08, 0.06, 0.04 micrograms/ml. Altertoxin II was the most cytoxic in the V79 system, followed by altertoxins III and I. The last cytotoxic of the three, altertoxin I, weakly disrupted metabolic communication at two concentrations (4 and 5 micrograms/ml). Altertoxins III and II did not significantly inhibit gap junction communication more than the weak tumor promoter 4-O-methyl ether tetradecanoylphorbol 13-acetate. JF - Journal of toxicology and environmental health AU - Boutin, B K AU - Peeler, J T AU - Twedt, R M AD - Food and Drug Administration, Division of Microbiology, Cincinnati, Ohio. Y1 - 1989 PY - 1989 DA - 1989 SP - 75 EP - 81 VL - 26 IS - 1 SN - 0098-4108, 0098-4108 KW - Benz(a)Anthracenes KW - 0 KW - Mycotoxins KW - altertoxin III KW - 105579-74-6 KW - altertoxin II KW - 56257-59-1 KW - altertoxin I KW - 56258-32-3 KW - Perylene KW - 5QD5427UN7 KW - Index Medicus KW - Perylene -- analogs & derivatives KW - Fibroblasts -- drug effects KW - Animals KW - Cells, Cultured KW - Cell Communication -- drug effects KW - Intercellular Junctions -- drug effects KW - Cricetinae KW - Alternaria -- metabolism KW - Lung -- drug effects KW - Lung -- metabolism KW - Benz(a)Anthracenes -- toxicity KW - Mitosporic Fungi -- metabolism KW - Mycotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78832933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Effects+of+purified+altertoxins+I%2C+II%2C+and+III+in+the+metabolic+communication+V79+system.&rft.au=Boutin%2C+B+K%3BPeeler%2C+J+T%3BTwedt%2C+R+M&rft.aulast=Boutin&rft.aufirst=B&rft.date=1989-01-01&rft.volume=26&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-09 N1 - Date created - 1989-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98. AN - 78824740; 2643031 AB - Using the Ames Salmonella/microsome assay, we compared the antimutagenic activities of chlorophyllin, retinol, beta-carotene, vitamin C, and vitamin E against solvent extracts of coal dust, diesel emission particles, airborne particles, fried beef, and tobacco snuff. The results show that chlorophyllin inhibited 69% of the mutagenic activity of tobacco snuff and over 90% of that of the other 4 complex mixtures. Retinol inhibited 29-48% of the mutagenic activity of all 5 complex mixtures. beta-Carotene, vitamin C, and vitamin E inhibited, if any, less than 39% of the activity of the complex mixtures studied. Vitamin C enhanced the mutagenicity of airborne particles. These results indicate that for these dietary and environmental complex mixtures chlorophyllin is a more effective antimutagen than retinol, beta-carotene, vitamin C, and vitamin E. JF - Mutation research AU - Ong, T AU - Whong, W Z AU - Stewart, J D AU - Brockman, H E AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 19 EP - 25 VL - 222 IS - 1 SN - 0027-5107, 0027-5107 KW - Chlorophyllides KW - 0 KW - Coal KW - Dust KW - Fuel Oils KW - Mutagens KW - beta Carotene KW - 01YAE03M7J KW - Vitamin A KW - 11103-57-4 KW - Vitamin E KW - 1406-18-4 KW - Chlorophyll KW - 1406-65-1 KW - chlorophyllin KW - 1D276TYV9O KW - Carotenoids KW - 36-88-4 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Plants, Toxic KW - Meat KW - Mutagenicity Tests KW - Tobacco KW - Air KW - Vitamin A -- pharmacology KW - Chlorophyllides -- pharmacology KW - Vitamin E -- pharmacology KW - Mutagens -- isolation & purification KW - Salmonella typhimurium -- drug effects KW - Mutagens -- pharmacology KW - Carotenoids -- pharmacology KW - Ascorbic Acid -- pharmacology KW - Chlorophyll -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78824740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Comparative+antimutagenicity+of+5+compounds+against+5+mutagenic+complex+mixtures+in+Salmonella+typhimurium+strain+TA98.&rft.au=Ong%2C+T%3BWhong%2C+W+Z%3BStewart%2C+J+D%3BBrockman%2C+H+E&rft.aulast=Ong&rft.aufirst=T&rft.date=1989-01-01&rft.volume=222&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-16 N1 - Date created - 1989-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases. AN - 78820900; 2908851 AB - Metabolic N-oxidation and ring-oxidation of carcinogenic arylamines by hepatic cytochromes P-450 are generally regarded as critical activation and detoxification pathways, respectively. Two arylamines with known human exposure, 4-aminobiphenyl (ABP) and 4,4'-methylene-bis(2-chloroaniline) (MOCA), have been examined as substrates for 10 different purified rat hepatic cytochromes P-450 and for human liver microsomal preparations from 22 individuals. Metabolites were analyzed by high-performance liquid chromatography and flow scintillation techniques. As reported for certain other carcinogenic arylamines, the isosafrole-inducible isozyme, P-450ISF-G, had the highest catalytic activity for ABP N-oxidation (13.6 nmol/min/nmol P-450), but P-450BNF-B, P-450UT-A, P-450UT-F, and P-450PB-B also showed appreciable activity. Ring-oxidation of ABP occurred only to a minor extent. In contrast, N-oxidation of MOCA was preferentially catalyzed by the phenobarbital-inducible enzymes, P-450PB-B and P-450PB-D (9.0 and 6.6 nmol/min/nmol P-450, respectively). MOCA ring-oxidation and methylene carbon oxidation showed varied cytochrome P-450 selectivity and accounted for 14 to 79% of total oxidation products. There was a 44-fold variation in rates of ABP N-oxidation in the 22 human liver microsomal preparations, while rates of N-oxidation of MOCA varied only 8-fold. Ring/methylene carbon-oxidation of MOCA accounted for 6-19% of total oxidation products in the case of the human microsomal preparations, whereas ring-oxidation of ABP accounted for less than 7% of total oxidation. In addition, there was a strong correlation (R = 0.90) between rates of ABP N-oxidation and phenacetin O-deethylation, which is considered a human genetic polymorphism. Moreover, both the ABP N-oxidation and phenacetin O-deethylation activities of human liver microsomes showed a good correlation (R = 0.72) with the levels of cytochrome P-450 immunochemically related to rat P-450ISF-G. These data indicate that specific inducible and constitutive cytochromes P-450 are involved in the metabolic activation and detoxification of the carcinogens ABP and MOCA. Therefore, individual profiles of cytochromes P-450, affected by both environmental and genetic factors, may be significant determinants of individual susceptibility to arylamine carcinogenesis. JF - Cancer research AU - Butler, M A AU - Guengerich, F P AU - Kadlubar, F F AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 1989/01/01/ PY - 1989 DA - 1989 Jan 01 SP - 25 EP - 31 VL - 49 IS - 1 SN - 0008-5472, 0008-5472 KW - Aminobiphenyl Compounds KW - 0 KW - Benzhydryl Compounds KW - Carcinogens KW - Benzphetamine KW - 0M3S43XK27 KW - 4-biphenylamine KW - 16054949HJ KW - Methylenebis(chloroaniline) KW - 3L2W5VTT2A KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Phenacetin KW - ER0CTH01H9 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Polymorphism, Genetic KW - Biotransformation KW - Humans KW - Benzphetamine -- metabolism KW - Phenacetin -- metabolism KW - Carcinogens -- metabolism KW - Methylenebis(chloroaniline) -- metabolism KW - Microsomes, Liver -- metabolism KW - Benzhydryl Compounds -- metabolism KW - Cytochrome P-450 Enzyme System -- pharmacology KW - Aminobiphenyl Compounds -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78820900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Metabolic+oxidation+of+the+carcinogens+4-aminobiphenyl+and+4%2C4%27-methylene-bis%282-chloroaniline%29+by+human+hepatic+microsomes+and+by+purified+rat+hepatic+cytochrome+P-450+monooxygenases.&rft.au=Butler%2C+M+A%3BGuengerich%2C+F+P%3BKadlubar%2C+F+F&rft.aulast=Butler&rft.aufirst=M&rft.date=1989-01-01&rft.volume=49&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-25 N1 - Date created - 1989-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Child Health USA'89. AN - 63032946; ED314421 AB - This booklet is a report of the health status and service needs of America's children. It presents a summary of sentinel health measures reflecting both what has been accomplished and what challenges remain. The first section describes the general population to provide a context for health measures. In the second section, selected health status measures are presented graphically with accompanying text organized according to three age groups--infants, children, and adolescents. In the third section, measures of health services utilization are presented. (JD) Y1 - 1989 PY - 1989 DA - 1989 SP - 51 KW - Child Health KW - ERIC, Resources in Education (RIE) KW - Health Services KW - Dental Health KW - Infant Mortality KW - Physical Health KW - Adolescents KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63032946?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Photographs will not reproduce. N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Tests on the Pathway to a Health Career. AN - 63019570; ED319305 AB - The guide was developed by the Health Careers Opportunity Program, the principal Federal program focused on increasing the numbers of disadvantaged individuals who train for and enter the health professions. The guide is intended to help institutional grantees working with such students in the areas of: (1) diagnostic testing in cognitive and psychosocial processes, (2) diagnostic testing to determine student strengths and weaknesses in test-taking skills, (3) admission tests, and (4) credentialing tests. The publication summarizes 41 tests and is divided into three sections--diagnostic tests (10), admission tests (12), and credentialing examinations (19). For each test the following information is usually provided: purpose or use of the test; educational level or levels the test is appropriate for; a description of the areas assessed by the instrument; test format; time factors; type of scoring and how scores are used; dates of national examinations; and name, address, and telephone number of the source of the test. (DB) Y1 - 1989 PY - 1989 DA - 1989 SP - 59 KW - Health Careers Opportunity Program KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Administrators KW - College Entrance Examinations KW - Diagnostic Tests KW - Disadvantaged KW - Test Anxiety KW - Higher Education KW - Licensing Examinations (Professions) KW - Credentials KW - Test Wiseness KW - Health Occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63019570?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Women and AIDS: initiatives of the Public Health Service; a report, 1987 AN - 59518252; 1990-0405831 AB - Reports on the activities of the Alcohol, Drug Abuse, and Mental Health Administration, the Centers for Disease Control, and other federal agencies. JF - Room 949, Westwood Bldg., 5333 Westbard Av., Bethesda, MD 20892, 1989. Y1 - 1989///0, PY - 1989 DA - 0, 1989 PB - Room 949, Westwood Bldg., 5333 Westbard Av., Bethesda, MD 20892 KW - Acquired immune deficiency syndrome KW - Women -- Health KW - United States -- Public health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59518252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Women+and+AIDS%3A+initiatives+of+the+Public+Health+Service%3B+a+report%2C+1987&rft.title=Women+and+AIDS%3A+initiatives+of+the+Public+Health+Service%3B+a+report%2C+1987&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 949, Westwood Bldg., 5333 Westbard Av., Bethesda, MD 20892 pa N1 - Document feature - table(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - A comprehensive health care program for American Indians and Alaska natives AN - 59515391; 1990-0204114 AB - Overview of federal medical services. JF - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857, 1989. vi+22 pp. Y1 - 1989///0, PY - 1989 DA - 0, 1989 EP - vi+22 PB - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 KW - Alaska -- Native races KW - Indians -- Medical care KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59515391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=vi%2B22&rft.isbn=&rft.btitle=A+comprehensive+health+care+program+for+American+Indians+and+Alaska+natives&rft.title=A+comprehensive+health+care+program+for+American+Indians+and+Alaska+natives&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - Room 6A-20, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857 N1 - Document feature - il(s), table(s), map(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Microbial Degradation of Polycyclic Aromatic Hydrocarbons (PAH) in the Aquatic Environment AN - 19053814; 8911828 AB - Microorganisms play an important role in recycling of elements such as carbon, nitrogen, phosphorus, oxygen, and sulfur and in the degradation of organic compounds to carbon dioxide and water in nature. Microorganisms have adapted to the wide array of natural and synthetic organic compounds emitted into the environment and possess enzymes that utilize some of these compounds as nutrients. In recent years, the concern about the presence of polycyclic aromatic hydrocarbons (PAH) in air, soil, and water systems has increased, since this important class of chemicals is carcinogenic in experimental animals and a potential health risk to man. PAH are mainly formed as products from the combustion of fossil fuels and also occur as natural constituents of unaltered fossil fuels. Due to their hydrophobic properties and limited water solubility, PAH tend to adsorb to particulates and eventually migrate to the sediments in river, lake, estuarine, and marine waters. Lower molecular weight PAH, such as naphthalene and its alkylated derivatives, are relatively water soluble, but PAH containing three or more fused benzene rings, due to their hydrophobic nature, are bound and transported by fine particles and dissolved organic matter in aquatic environments. Although PAH may undergo volatilization, photodecomposition, and degradation while in open waters, most sediment deposition occurs below the photolytic zone, and the primary factor affecting the persistence of deposited PAH is microbial degradation. To date, most studies have examined the biodegradation of naphthalene, anthracene, phenanthrene, benz(a)anthracene, or benzo(a)pyrene. Some limited data are available for the biodegradation of 2-methylnaphthalene, dimethylbenz(a)anthracene, pyrene, fluorene, and chrysene, but little or no data exist for other common PAH and their alkylated derivatives. Relationships have been shown to exist between the rate of PAH biodegradation in aquatic ecosystems and the chemical structure and molecular weight of PAH, microbial adaptations occurring from chronic exposure to PAH, oxygen tension, redox potential, and temperature. The effects of these factors on PAH biodegradation in aquatic ecosystems are reviewed in this paper. (See also W89-11826) (Lantz-PTT) JF - Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment. CRC Press, Inc., Boca Raton Florida. 1989. p 41-68, 111 fig, 3 tab, 114 ref. AU - Cerniglia, CE AU - Heitkamp, MA AD - National Center for Toxicological Research Jefferson, AR Y1 - 1989 PY - 1989 DA - 1989 KW - Water Resources Abstracts KW - Hydrocarbons KW - Microbial degradation KW - Fate of pollutants KW - Biodegradation KW - Polycyclic aromatic hydrocarbons KW - Aquatic environment KW - Adaptation KW - Organic compounds KW - Temperature KW - Molecular structure KW - Chemical reactions KW - Sediment contamination KW - Cycling nutrients KW - Air pollution KW - Soil contamination KW - Water pollution KW - Carcinogens KW - Adsorption KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19053814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Microbial+Degradation+of+Polycyclic+Aromatic+Hydrocarbons+%28PAH%29+in+the+Aquatic+Environment&rft.au=Cerniglia%2C+CE%3BHeitkamp%2C+MA&rft.aulast=Cerniglia&rft.aufirst=CE&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Effect of sulfide minerals on ferrous alloy grinding media corrosion AN - 1773801202; 2016-021936 AB - The effect of common sulphide minerals on the corrosion rate of various types of ferrous alloy grinding media was determined. Data obtained from this study will aid in determining the contribution of any electrochemical reactions between sulphide minerals and grinding media to the total grinding media consumption. Common sulphide minerals used in this study were chalcopyrite, galena and sphalerite. In the presence of oxygen, chalcopyrite was found to increase the corrosion rate, galena was found to decrease the corrosion rate, and the effect of sphalerite was dependent upon the type of grinding media. Possible electrochemical reactions of these minerals in the presence of grinding media are suggested. JF - Bureau of Mines Report of Investigations AU - Isaacson, A E Y1 - 1989 PY - 1989 DA - 1989 SP - 19 PB - U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Washington, D.C. VL - 9244 SN - 0096-1922, 0096-1922 KW - corrosion KW - experimental studies KW - oxygen KW - copper KW - sphalerite KW - rates KW - steel KW - grinding KW - electrochemical properties KW - chalcopyrite KW - iron KW - ferrous iron KW - galena KW - chemical reactions KW - metals KW - alloys KW - sulfides KW - pH KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773801202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bureau+of+Mines+Report+of+Investigations&rft.atitle=Effect+of+sulfide+minerals+on+ferrous+alloy+grinding+media+corrosion&rft.au=Isaacson%2C+A+E&rft.aulast=Isaacson&rft.aufirst=A&rft.date=1989-01-01&rft.volume=9244&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Bureau+of+Mines+Report+of+Investigations&rft.issn=00961922&rft_id=info:doi/ L2 - http://catalog.hathitrust.org/Record/005950797 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 20 N1 - PubXState - D.C. N1 - Document feature - illus. incl. 11 tables N1 - SuppNotes - Accessed on Oct. 20, 2015 N1 - Last updated - 2016-03-17 N1 - CODEN - XBMIA6 N1 - SubjectsTermNotLitGenreText - alloys; chalcopyrite; chemical reactions; copper; corrosion; electrochemical properties; experimental studies; ferrous iron; galena; grinding; iron; metals; oxygen; pH; rates; sphalerite; steel; sulfides ER - TY - JOUR T1 - The chick assay for PSP: An alternative to the mouse bioassay useful in rural areas. AN - 15856515; 2452819 AB - Shellfish are frequently produced and PSP occurs in locations far from laboratories where PSP assays are typically conducted. When it is impractical to ship samples from these locations to the central laboratory for assay, it is desirable to set up a field laboratory to conduct bioassays but in such a location it may be difficult to obtain mice to perform the standard bioassay. Such a situation prevails in the Philippines, where PSP has become a severe problem in recent years. However, chickens are typically raised in the rural villages and chicks are readily available on a regular basis. The use of chicks as assay animals was investigated and it was found that they were a practical alternative for such situations. Sensitivity was equal to or greater than the mouse bioassay and precision was adequate for use in shellfish toxicity monitoring. It is therefore possible for shellfish growers in remote locations to set up low cost monitoring programs to check their products. JF - Journal of Shellfish Research AU - Gomaa, M N AU - Hall, S AU - Doerr, JA AD - FDA, HFF-423, 200 C St. SW, Washington, DC 20204, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 484 VL - 8 IS - 2 SN - 0730-8000, 0730-8000 KW - shellfish KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts KW - Marine KW - biological poisons KW - food poisoning KW - bioassays KW - methodology KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15856515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Shellfish+Research&rft.atitle=The+chick+assay+for+PSP%3A+An+alternative+to+the+mouse+bioassay+useful+in+rural+areas.&rft.au=Gomaa%2C+M+N%3BHall%2C+S%3BDoerr%2C+JA&rft.aulast=Gomaa&rft.aufirst=M&rft.date=1989-01-01&rft.volume=8&rft.issue=2&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Journal+of+Shellfish+Research&rft.issn=07308000&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Summary only. N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - biological poisons; bioassays; food poisoning; methodology; Marine ER - TY - JOUR T1 - Preliminary collaborative study of the HPLC method for PSP toxins. AN - 15856306; 2452790 AB - Paralytic shellfish poisoning (PSP) results from the ingestion of neurotoxins bioaccumulated in shellfish following blooms of Alexandrium . Among the promising instrumental methods for detecting PSP toxins is a high pressure, liquid chromatographic method developed by FDA. The method provides a toxin profile and is more sensitive than the mouse bioassay currently used. Sophisticated instrumentation is required, and the method involves careful control of several experimental variables. A pre-collaborative study has been initiated to assess equipment requirements and method ruggedness. Preliminary results are presented and other approaches to screening for PSP toxins are discussed. JF - Journal of Shellfish Research AU - Hungerford, J M AU - Wekell, M M AU - Hall, S AD - FDA, Seafood Prod. Res. Cent., Bothell, WA, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 484 VL - 8 IS - 2 SN - 0730-8000, 0730-8000 KW - shellfish KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts KW - chromatographic techniques KW - Marine KW - Alexandrium KW - neurotoxins KW - biological poisons KW - food poisoning KW - bioassays KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15856306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Shellfish+Research&rft.atitle=Preliminary+collaborative+study+of+the+HPLC+method+for+PSP+toxins.&rft.au=Hungerford%2C+J+M%3BWekell%2C+M+M%3BHall%2C+S&rft.aulast=Hungerford&rft.aufirst=J&rft.date=1989-01-01&rft.volume=8&rft.issue=2&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Journal+of+Shellfish+Research&rft.issn=07308000&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Summary only. N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - chromatographic techniques; neurotoxins; biological poisons; bioassays; food poisoning; Alexandrium; Marine ER - TY - JOUR T1 - Vibrio specific of the U.S. West Coast. AN - 15850230; 2453009 AB - Species of the Genus Vibrio have been of interest to the FDA during the past 2 decades. Most recently, the survival of V. vulnificus in harvested oysters, the emergence of a unique bioserovar of V. parahaemolyticus on the West Coast and septicemia caused by V. cholerae non-01 has been investigated by the SPRC. In studies, V. vulnificus survived in both Crassostrea virginica and C. gigas for at least one week after injection of live cells into both shellstock and commercially shucked product stored at 10 degree C and on ice (0.5 degree C). A unique bioserovar of V. parahaemolyticus has been identified as a predominant strain isolated from patients in CA. This urease positive (Uh +) 04:K 12 serogroup was determined to be in some cases from shellfish harvested from West Coast waters. A high percentage of Uh + strains was found in the total V. parahaemolyticus population in one oyster growing estuary in the State of WA. An unusual case of V. cholerae septic shock occurred recently in Wa. The patient was compromised and died before a food history could be obtained. Biochemically identical non-toxigenic, non-01 V. cholerae strains were isolated from estuarine sediments near the residence of the patient; suggesting the source of the organism from the sediment. JF - Journal of Shellfish Research AU - Kaysner, CA AD - Seafood Prod. Res. Cent., FDA, Bothell, WA 98041, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 449 EP - 450 VL - 8 IS - 2 SN - 0730-8000, 0730-8000 KW - public health KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts KW - Marine KW - Vibrio KW - microbial contamination KW - seafood KW - food poisoning KW - INE, USA KW - Crassostrea KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15850230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Shellfish+Research&rft.atitle=Vibrio+specific+of+the+U.S.+West+Coast.&rft.au=Kaysner%2C+CA&rft.aulast=Kaysner&rft.aufirst=CA&rft.date=1989-01-01&rft.volume=8&rft.issue=2&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Journal+of+Shellfish+Research&rft.issn=07308000&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Summary only. N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - microbial contamination; seafood; food poisoning; Vibrio; Crassostrea; INE, USA; Marine ER - TY - JOUR T1 - Morbidity and mortality among low birth weight infants exposed to an intravenous vitamin E product, E-ferol. AN - 15806846; 2413064 AB - In April 1984, the US FDA was notified of an unusual clinical syndrome consisting of ascites, liver and renal failure, thrombocytopenia, and death among low birth weight infants exposed to an intravenous vitamin E preparation, E-Ferol. The product, which had not been tested for safety prior to marketing, was voluntarily withdrawn from the market in early April. To further investigate the reported associations, the FDA conducted a retrospective cohort study among seven neonatal intensive care units where the product had been used. Compared with the unexposed infants, the exposed infants were more likely to die and to have ascites, hepatomegaly, thrombocytopenia, and a combination of clinical events similar to the syndrome initially reported. We conclude that the use of E-Ferol in these neonatal intensive care units was associated with increased morbidity and mortality among exposed infants. JF - Pediatrics AU - Arrowsmith, J B AU - Faich, G A AU - Tomita, D K AU - Kuritsky, J N AU - Rosa, F W AD - Off. Epidemiol. and Biostat., Cent. Drug Eval. and Res., FDA, Rockville, MD 20857, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 244 EP - 249 VL - 83 IS - 2 SN - 0031-4005, 0031-4005 KW - E-Ferol KW - alpha -tocopherol KW - Toxicology Abstracts KW - mortality KW - infants KW - morbidity KW - man KW - X 24120:Food, additives & contaminants KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15806846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Morbidity+and+mortality+among+low+birth+weight+infants+exposed+to+an+intravenous+vitamin+E+product%2C+E-ferol.&rft.au=Arrowsmith%2C+J+B%3BFaich%2C+G+A%3BTomita%2C+D+K%3BKuritsky%2C+J+N%3BRosa%2C+F+W&rft.aulast=Arrowsmith&rft.aufirst=J&rft.date=1989-01-01&rft.volume=83&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - morbidity; mortality; infants; man ER - TY - JOUR T1 - Fluoroquinolones and theophylline toxicity: Norfloxacin. AN - 15796295; 2413284 AB - Three cases have been reported to the Food and Drug Administration that suggest theophylline toxic effects in patients taking norfloxacin. Each patient had a baseline steady-state theophylline level that was increased by at least 50% after starting norfloxacin therapy. A judgment was made that concomitant drugs or diseases were not likely to be responsible. All three patients were older than 60 years and had chronic obstructive pulmonary disease. One patient died of a theophylline-induced seizure with pulmonary aspiration. The other two had positive dechallenge on withdrawal of norfloxacin administration and recovered. A report of one of these follows. JF - Journal of the American Medical Association AU - Green, L AU - Clark, J AD - FDA, Rockville, MD 20857, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 2383 VL - 262 IS - 17 SN - 0098-7484, 0098-7484 KW - norfloxacin KW - case reports KW - theophylline KW - Toxicology Abstracts KW - side effects KW - diuretics KW - antimicrobial agents KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15796295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=Fluoroquinolones+and+theophylline+toxicity%3A+Norfloxacin.&rft.au=Green%2C+L%3BClark%2C+J&rft.aulast=Green&rft.aufirst=L&rft.date=1989-01-01&rft.volume=262&rft.issue=17&rft.spage=2383&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - side effects; man; antimicrobial agents; diuretics ER - TY - BOOK T1 - Back injury control programs for nursing staff. AN - 15578222; 2228837 AB - Most hospitals and nursing homes find that back injuries among nursing staff are frequent and costly. In spite of an awareness of the problem, most hospital administrators are unaware of the range of programs to reduce the incidence and cost of back injuries. This article provides ideas for improving back injury control programs based on the best information available. AU - Jensen, R Y1 - 1989 PY - 1989 DA - 1989 SP - 6 EP - 172 KW - back injuries KW - nursing homes KW - Health & Safety Science Abstracts KW - ergonomics KW - occupational health KW - hospitals KW - H SM1.7:HUMAN FACTORS KW - H SM9.46:BACK INJURIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15578222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jensen%2C+R&rft.aulast=Jensen&rft.aufirst=R&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=Back+injury+control+programs+for+nursing+staff.&rft.title=Back+injury+control+programs+for+nursing+staff.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the serum of U.S. chemical workers exposed to dioxin contaminated products: Interim results. AN - 15561150; 2221402 AB - NIOSH is conducting a medical study to evaluate the current health status of 400 chemical workers who made products contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and an unexposed referent group matched for age, sex, race and neighborhood of residence. The workers are from two U.S. facilities which produced 2,4,5-trichlorophenol and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) between 1951 and 1972. As a measure of their exposure to 2,3,7,8-TCDD, serum from each worker and from a sample of referents was analyzed for the concentration of this isomer. In this preliminary report, we present the results of the analyses for 2,3,7,8-TCDD found in the serum of 46 study participants. In general, the mean of 8.2 parts per trillion (ppt) 2,3,7,8-TCDD found in the unexposed group is comparable to levels found in unexposed persons in industrialized nations. JF - Chemosphere AU - Fingerhut, MA AU - Sweeney, M H AU - Patterson, DG Jr AU - Piacitelli, LA AU - Morris, JA AU - Marlow, DA AU - Hornung, R W AU - Cameron, L W AU - Connally, L B Y1 - 1989 PY - 1989 DA - 1989 SP - 835 EP - 840 VL - 19 IS - 1-6 KW - TCDD KW - Pollution Abstracts KW - contamination KW - occupational health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15561150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Levels+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+in+the+serum+of+U.S.+chemical+workers+exposed+to+dioxin+contaminated+products%3A+Interim+results.&rft.au=Fingerhut%2C+MA%3BSweeney%2C+M+H%3BPatterson%2C+DG+Jr%3BPiacitelli%2C+LA%3BMorris%2C+JA%3BMarlow%2C+DA%3BHornung%2C+R+W%3BCameron%2C+L+W%3BConnally%2C+L+B&rft.aulast=Fingerhut&rft.aufirst=MA&rft.date=1989-01-01&rft.volume=19&rft.issue=1-6&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Nephropathy in cadmium workers: Assessment of risk from airborne occupational exposure to cadmium. AN - 15444744; 2179067 AB - To assess the quantitative relation between exposure to airborne cadmium and various markers of renal tubular and glomerular function, 45 male workers employed at a plant that recovers cadmium from industrial waste and 32 male hospital workers of similar age and geographical location were examined. Cumulative external exposure to airborne cadmium (dose) was estimated from historical air sampling data, adjusted for respirator use. Increasing cadmium dose was associated with multiple renal tubular functional abnormalities, including reduced reabsorption of beta-2-microglobulin ( beta -2), retinol binding protein (RBP), calcium, and phosphate. Serum creatinine concentration also increased with cadmium dose, suggesting impaired glomerular function. Mean systolic and diastolic blood pressures were higher in the cadmium workers than in the unexposed (134 v 120 mm Hg and 80 v 73 mm Hg respectively), but only systolic blood pressure was significantly associated with cadmium dose in multivariate analyses. Cadmium dose remained the most important predictor of serum creatinine concentration after controlling for age, blood pressure, body size, and other extraneous factors. JF - Occupational and Environmental Medicine AU - Thun, MJ AU - Osorio, A M AU - Schober, S AU - Hannon, W H AU - Lewis, B AU - Halperin, W AD - NIOSH, Industrywide Stud. Branch, Cincinnati, OH 45226, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 689 EP - 697 VL - 46 IS - 10 SN - 0007-1072, 0007-1072 KW - cadmium KW - function KW - serum creatinine KW - man KW - kidneys KW - creatinine KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - risk assessment KW - kidney KW - occupational exposure KW - X 24165:Biochemistry KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15444744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Nephropathy+in+cadmium+workers%3A+Assessment+of+risk+from+airborne+occupational+exposure+to+cadmium.&rft.au=Thun%2C+MJ%3BOsorio%2C+A+M%3BSchober%2C+S%3BHannon%2C+W+H%3BLewis%2C+B%3BHalperin%2C+W&rft.aulast=Thun&rft.aufirst=MJ&rft.date=1989-01-01&rft.volume=46&rft.issue=10&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - occupational exposure; kidney; risk assessment; man ER - TY - PAT T1 - Method for detecting antibodies against neuropeptides and drugs in human body fluid. AN - 15432769; 2174360 AU - Roy, BF III PY - 1989 IS - US Patent 4,868,107 KW - neuropeptides KW - detection KW - methodology KW - antibodies KW - patents KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents KW - W 30507:Diagnostic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15432769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Method+for+detecting+antibodies+against+neuropeptides+and+drugs+in+human+body+fluid.&rft.au=Roy%2C+BF+III&rft.aulast=Roy&rft.aufirst=BF&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/7; Int. Cl. G01N 33/545, 33/564. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Genotoxicity and genotoxic enhancing effect of tetrandrine in Salmonella typhimurium . AN - 15418334; 2155823 AB - Tetrandrine has been used for the treatment of silicosis in China. The potential genotoxic and carcinogenic hazards of this drug were studied using the Salmonella/histidine reversion assay and the SOS/Umu test. The results show that tetrandrine was weakly mutagenic to Salmonella typhimurium TA98 with metabolic activation and did not induce SOS response. However, tetrandrine increased the mutagenic activity of benzo( alpha )pyrene, trinitrofluorenone (TNF), 2-aminoanthracene (2AA), diesel emission particles, airborne particles, and cigarette smoke condensate by more than 100%; the activity of aflatoxin B sub(1) and fried beef was increased by over 75%. JF - Mutation Research AU - Whong, W-Z AU - Lu, C-H AU - Stewart, J D AU - Jiang, H-X AU - Ong, T AD - NIOSH, DRDS, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 237 EP - 244 VL - 222 IS - 3 SN - 0027-5107, 0027-5107 KW - tetrandrine KW - use KW - Ames test KW - Health & Safety Science Abstracts; Toxicology Abstracts; Genetics Abstracts KW - genotoxicity KW - mutation KW - H SM5.8.2:CHEMICALS (CORROSION) KW - X 24117:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15418334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Genotoxicity+and+genotoxic+enhancing+effect+of+tetrandrine+in+Salmonella+typhimurium+.&rft.au=Whong%2C+W-Z%3BLu%2C+C-H%3BStewart%2C+J+D%3BJiang%2C+H-X%3BOng%2C+T&rft.aulast=Whong&rft.aufirst=W-Z&rft.date=1989-01-01&rft.volume=222&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - genotoxicity; Ames test; mutation ER - TY - JOUR T1 - Effects of different extraction protocols on endotoxin analyses of airborne grain dusts. AN - 15407486; 2157945 AB - The detection of gram-negative bacterial endotoxins in occupational dusts, specifically those from agricultural environments, is of increasing importance in research on occupational lung disease. In this study, the quantitative chromogenic Limulus amebocyte lysate test for the detection of endotoxins in airborne dusts from spring wheat and oats were examined. Different extraction fluids were tested, as were the effects of time on extraction and of repeated freeze-thaw cycles on the extracts. The data suggest that the chromogenic method can be used effectively in the analysis of environmental dusts or their frozen extracts for endotoxin quantitation. Water appears to be the preferable extraction medium, and the length of extraction time may affect the results. JF - Scandinavian Journal of Work, Environment & Health AU - Olenchock, SA AU - Lewis, D M AU - Mull, J C AD - Immunol. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 430 EP - 435 VL - 15 IS - 6 SN - 0355-3140, 0355-3140 KW - occupational health KW - endotoxins KW - Pollution Abstracts; Health & Safety Science Abstracts KW - agriculture KW - dust KW - respiratory diseases KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - P 0000:AIR POLLUTION KW - P 6000:TOXICOLOGY AND HEALTH KW - H SE2.8.7:DUST UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15407486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Effects+of+different+extraction+protocols+on+endotoxin+analyses+of+airborne+grain+dusts.&rft.au=Olenchock%2C+SA%3BLewis%2C+D+M%3BMull%2C+J+C&rft.aulast=Olenchock&rft.aufirst=SA&rft.date=1989-01-01&rft.volume=15&rft.issue=6&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - dust; agriculture; respiratory diseases ER - TY - PAT T1 - Pertussis toxin gene: Cloning and expression of protective antigen. AN - 15370348; 2124756 AU - Keith, J M AU - Locht, C PY - 1989 IS - US Patent 4,883,761 KW - pertussis KW - cloning KW - expression KW - antigens KW - genes KW - patents KW - toxins KW - Biotechnology and Bioengineering Abstracts KW - W 30134:Microorganisms KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15370348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Pertussis+toxin+gene%3A+Cloning+and+expression+of+protective+antigen.&rft.au=Keith%2C+J+M%3BLocht%2C+C&rft.aulast=Keith&rft.aufirst=J&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435-320; Int. Cl. C12N 1/00, 15/00, 1/20, C07H 21/04. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Inhibition of methylation of DNA by dimethylnitrosamine (DMN) in dehydroepiandrosterone-fed rats. AN - 15357259; 2109997 AB - The influence of the anticarcinogen dehydroepiandrosterone (DHEA) on the metabolism and macromolecular interactions of the potent hepatocarcinogen dimethylnitrosamine (NDMA) was investigated. Male Sprague-Dawley rat (2-3 mo old) were fed DHEA for 14 d at a dietary level of 0.8%. Compared with pair-fed controls, the liver weights of the DHEA-treated animals increased significantly (11.7 vs. 7.1 g) with increases, per total liver, proteins including those of cytosol and microsomes as well as cytochromes P-450 and b sub(5). DNA content of the liver, however, remained constant. Five hours after a single ip dose of ( super(14)C)NDMA (30 mg/kg body wt, 42 mu Ci/rat) DNA methylation was reduced in the DHEA-fed animals as measured by 7-methyl- and O super(6)-methylguanine per mole of guanine, by 39 and 31%, respectively. The rate of NDMA metabolism was slightly higher in the DHEA-fed rats as determined in vivo by the exhalation of super(14)CO sub(2) and by the declining concentrations of NDMA in the blood. JF - Journal of Toxicology and Environmental Health AU - Prasanna, H R AU - Magee, P N AU - Harrington, G W AU - Hart, R W AD - DHHS/PHS/FDA (HFT-1), Natl. Cent. Toxicol. Res., Jefferson, AR 72079, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 467 EP - 476 VL - 27 IS - 4 SN - 0093-4108, 0093-4108 KW - N-nitrosodimethylamine KW - inhibition KW - dehydroepiandrosterone KW - rats KW - Toxicology Abstracts KW - methylation KW - DNA KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15357259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Inhibition+of+methylation+of+DNA+by+dimethylnitrosamine+%28DMN%29+in+dehydroepiandrosterone-fed+rats.&rft.au=Prasanna%2C+H+R%3BMagee%2C+P+N%3BHarrington%2C+G+W%3BHart%2C+R+W&rft.aulast=Prasanna&rft.aufirst=H&rft.date=1989-01-01&rft.volume=27&rft.issue=4&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; methylation ER - TY - JOUR T1 - Microbreak length, performance, and stress in a data entry task. AN - 15340325; 2098682 AB - The effects of brief rest pauses on performance and well-being were evaluated for a highly repetitive, data entry task. Experienced data entry operators (N = 20) performed the task in a two-day experiment in a simulated office environment. Each day was divided into six, 40-min work periods. Subjects took a brief rest pause at the workstation (microbreak) in the middle of each work period. Subjects were instructed to terminate this microbreak when ready to resume work. Keystroke rate, error rate, correction rate, heart rate and heart rate variability were scored for each half of the work period. In addition, mood states before and during the work period were assessed. Microbreaks were found to average 27 multiplied by 4s in duration. High ratings of fatigue and boredom during the work period were associated with longer microbreaks, suggesting that the break period was self-adjusted relative to mood state. JF - Ergonomics AU - Henning, R A AU - Sauter, S L AU - Salvendy, G AU - Krieg, EF Jr AD - NIOSH, Robert A. Taft Lab., Cincinnati, OH 45226, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 855 EP - 864 VL - 32 IS - 7 SN - 0014-0139, 0014-0139 KW - behavioral research KW - performance KW - workstations KW - personnel KW - man machine interactions KW - ergonomics KW - human factors KW - psychology KW - stress KW - Health & Safety Science Abstracts KW - H SI0.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15340325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Microbreak+length%2C+performance%2C+and+stress+in+a+data+entry+task.&rft.au=Henning%2C+R+A%3BSauter%2C+S+L%3BSalvendy%2C+G%3BKrieg%2C+EF+Jr&rft.aulast=Henning&rft.aufirst=R&rft.date=1989-01-01&rft.volume=32&rft.issue=7&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - psychology; stress; ergonomics; human factors ER - TY - JOUR T1 - Chloroform-induced multiple forms of ornithine decarboxylase: Differential sensitivity of forms to enhancement by diethyl maleate and inhibition by ODC-antizyme. AN - 15325666; 2083396 AB - The role of glutathione (GSH) and ornithine decarboxylase-antizyme (ODC-AZ) in the regulation of the chloroform-mediated stimulation of rat hepatic ornithine decarboxylase (ODC) was investigated. The authors have previously implicated roles for each while examining the chloroform effect on crude cytosolic enzyme preparations. In this study they examined the effect of pretreatment with diethyl maleate (DEM), a GSH-depleting agent, on the chloroform stimulation of the two forms of the rat hepatic ODC enzyme and the sensitivity of these two forms to inhibition by the ODC-AZ. While the pretreatment with DEM provided a greater amount of the two forms of the ODC enzyme, it also resulted in a differential stimulation of each form when compared to chloroform alone. Additionally, Peak II was 20-25% more sensitive to the same amount of ODC-AZ then Peak I ODC activity. JF - Journal of Toxicology and Environmental Health AU - Savage, RE Jr AU - Nofzinger, K AU - Bedell, C AU - DeAngelo, AB AU - Pereira, MA AD - CDC, NIOSH, DBBS, ETB, TMS, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 57 EP - 64 VL - 27 IS - 1 SN - 0093-4108, 0093-4108 KW - chloroform KW - isoenzymes KW - induction KW - antizymes KW - ornithine decarboxylase KW - diethyl maleate KW - rats KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - liver KW - enzymes KW - H SM10.41:HEPATIC DISEASES KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15325666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Chloroform-induced+multiple+forms+of+ornithine+decarboxylase%3A+Differential+sensitivity+of+forms+to+enhancement+by+diethyl+maleate+and+inhibition+by+ODC-antizyme.&rft.au=Savage%2C+RE+Jr%3BNofzinger%2C+K%3BBedell%2C+C%3BDeAngelo%2C+AB%3BPereira%2C+MA&rft.aulast=Savage&rft.aufirst=RE&rft.date=1989-01-01&rft.volume=27&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - liver; rats; enzymes ER - TY - JOUR T1 - NIOSH investigation: Two overcome by hydrogen sulfide. AN - 15315489; 2075094 AB - On January 31, 1989, a 29-year-old male maintenance worker (victim) entered a sewer manhole to repair a pipe and collapsed at the bottom. In a rescue attempt, a 43-year-old male maintenance co-worker entered the manhole and also collapsed. Both workers were pronounced dead at the scene. WPCF notified DSR of this multiple fatality and requested technical assistance. On April 5 and 6, 1989, a DSR research industrial hygienist met with the state OSHA compliance director and the company vice president to discuss the incident. JF - Operations Forum AU - Manwaring, J C AD - NIOSH, Morgantown, WV, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 8 EP - 10 VL - 6 IS - 8 SN - 0887-2104, 0887-2104 KW - hydrogen sulphide KW - Pollution Abstracts KW - maintenance KW - sewers KW - mortality KW - occupational health KW - P 3000:SEWAGE & WASTEWATER TREATMENT KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15315489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Operations+Forum&rft.atitle=NIOSH+investigation%3A+Two+overcome+by+hydrogen+sulfide.&rft.au=Manwaring%2C+J+C&rft.aulast=Manwaring&rft.aufirst=J&rft.date=1989-01-01&rft.volume=6&rft.issue=8&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Operations+Forum&rft.issn=08872104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - sewers; occupational health; maintenance; mortality ER - TY - JOUR T1 - Man asphyxiated during new sewer construction. AN - 15314377; 2074893 AB - On August 20, 1988, a 26-year-old male construction worker was asphyxiated after he entered a manhole with an oxygen deficient atmosphere. WPCF notified the Division of Safety Research of NIOSH and requested technical assistance. A research safety specialist discussed the accident with the state medical examiner and on September 22, met with local police and fire officials and the firm that employed the victim, and photographed the site. JF - Operations Forum AU - Smith, D L AD - Div. Saf. Res. NIOSH, Morgantown, WV, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 8 EP - 10 VL - 6 IS - 7 SN - 0887-2104, 0887-2104 KW - sewers KW - asphyxiation KW - Pollution Abstracts KW - construction KW - occupational health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15314377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Operations+Forum&rft.atitle=Man+asphyxiated+during+new+sewer+construction.&rft.au=Smith%2C+D+L&rft.aulast=Smith&rft.aufirst=D&rft.date=1989-01-01&rft.volume=6&rft.issue=7&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Operations+Forum&rft.issn=08872104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - construction; occupational health ER - TY - CONF T1 - Background concentrations of polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs) in office buildings in Boston, Massachusetts. AN - 15314085; 2075548 AB - Two office buildings were tested to determine the background surface and air concentrations of PCDFs and PCDDs. Surface samples showed higher concentrations of PCDDs than PCDFs, increase of PCDD concentration with degree of chlorination, similar concentrations of PCDFs irrespective of degree of chlorination, and significant correlations between concentrations of PCBs, and PCDFs, and PCDDs. Air samples generally contained non-detectable concentrations of PCDFs and lower chlorinated PCDDs; and a predominance of higher chlorinated PCDDs. These data define a concentration baseline for PCDFs and PCDDs in these buildings, but may be indicative of the concentrations present in other office buildings. JF - Chemosphere AU - Kominsky, J R AU - Kwoka, C D Y1 - 1989 PY - 1989 DA - 1989 SP - 599 EP - 608 VL - 18 IS - 1-6 KW - PCDF KW - Massachusetts, Boston KW - Pollution Abstracts KW - buildings KW - air sampling KW - PCDD KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15314085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Background+concentrations+of+polychlorinated+dibenzofurans+%28PCDFs%29+and+polychlorinated+dibenzo-p-dioxins+%28PCDDs%29+in+office+buildings+in+Boston%2C+Massachusetts.&rft.au=Kominsky%2C+J+R%3BKwoka%2C+C+D&rft.aulast=Kominsky&rft.aufirst=J&rft.date=1989-01-01&rft.volume=18&rft.issue=1-6&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - CONF T1 - Dose-response assessment: Dioxin. AN - 15303872; 2058824 JF - Chemosphere AU - Scheuplein, R J Y1 - 1989 PY - 1989 DA - 1989 SP - 7 EP - 15 VL - 18 IS - 1-6 KW - dioxin KW - dose response effects KW - TCDD KW - carcinogenicity testing KW - Toxicology Abstracts; Pollution Abstracts KW - toxicity testing KW - carcinogenesis KW - toxicology KW - animal models KW - mathematical models KW - dose-response effects KW - public health KW - X 24221:Toxicity testing KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15303872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Dose-response+assessment%3A+Dioxin.&rft.au=Scheuplein%2C+R+J&rft.aulast=Scheuplein&rft.aufirst=R&rft.date=1989-01-01&rft.volume=18&rft.issue=1-6&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - PAT T1 - Antiviral compositions and methods. AN - 15291819; 2046536 AB - A method for treating the cytopathic destructive effects of a retroviral disease in a host infected with a retrovirus comprises administering to said host an effective amount of an antiviral composition comprising an effective amount of at least one compound selected from the group consisting of 2',3'-dideoxyadenosine, 2',3'-dideoxyinosine, 2',3'-dideoxyguanosine, and salts and esters thereof in a pharmaceutically acceptable carrier. AU - Mitsuya, H AU - Broder, S PY - 1989 IS - US Patent 4,861,759 KW - patents KW - 2',3'-dideoxyadenosine KW - 2',3'-dideoxyguanosine KW - 2',3'-dideoxyinosine KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - retrovirus KW - antiviral agents KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15291819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Antiviral+compositions+and+methods.&rft.au=Mitsuya%2C+H%3BBroder%2C+S&rft.aulast=Mitsuya&rft.aufirst=H&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 514/46; Int. Cl. A61K 31/70, C07D 473/16, C07H 17/00, 19/06. N1 - Last updated - 2011-12-12 ER - TY - PAT T1 - Recombinant DNA clone encoding laminin receptor. AN - 15290135; 2045904 AB - A clone comprises a recombinant cDNA clone for encoding cell surface receptor for laminin having a nucleotide sequence which is given. AU - Sobel, ME AU - Liotta, LA AU - Wewer, U M AU - Jaye, M C AU - Drohan, W N PY - 1989 IS - US Patent 4,861,710 KW - patents KW - receptors KW - cDNA KW - laminin KW - nucleotide sequence KW - recombinants KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents KW - W 30119:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15290135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Recombinant+DNA+clone+encoding+laminin+receptor.&rft.au=Sobel%2C+ME%3BLiotta%2C+LA%3BWewer%2C+U+M%3BJaye%2C+M+C%3BDrohan%2C+W+N&rft.aulast=Sobel&rft.aufirst=ME&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/6; Int. Cl. C12Q 1/68, C07H 21/00, C12N 1/19, 1/185. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Work-related injuries in the meatpacking industry. AN - 15285357; 2044301 AB - National Institute for Occupational Safety and Health (NIOSH) surveillance efforts are directed towards identifying and studying high-risk industries. This research describes injuries and worker characteristics and suggests how these injuries may be prevented in one industry - the meatpacking industry. This industry has maintained the third highest injury rate among all U.S. manufacturing industries from 1976 through 1985. According to NIOSH data, 25 workers died from work-related injuries during 1980-1985. Injury data from the Bureau of Labor Statistics Supplementary Data System show that 76% of injured workers suffered strains, sprains, lacerations, contusions, or abrasions. The two major types of injury are: Struck by or against objects (25%) and overexertion including lifting, pulling, and throwing (31%). Handtools are involved in almost one half of all injuries. JF - Journal of Safety Research AU - Conroy, C AD - Div. Saf. Res., NIOSH, Cent. Dis. Control, Cincinnati, OH, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 47 EP - 53 VL - 20 IS - 2 SN - 0022-4375, 0022-4375 KW - occupational safety KW - meatpacking industry KW - Health & Safety Science Abstracts KW - risk assessment KW - statistics KW - H SE4.23:FOOD PACKAGING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15285357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Work-related+injuries+in+the+meatpacking+industry.&rft.au=Conroy%2C+C&rft.aulast=Conroy&rft.aufirst=C&rft.date=1989-01-01&rft.volume=20&rft.issue=2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - risk assessment; statistics ER - TY - JOUR T1 - Cohort and case-control analyses of workers exposed to vinyl chloride: An update. AN - 15279998; 2032644 AB - The mortality in a cohort of workers at a vinyl chloride polymerization plant has been updated, extending the period of observation from 1974 to 1986. Workers may have been exposed to vinyl chloride monomer and/or polyvinyl chloride dust, or may have had no exposure to either substance. Seventy-six percent of the work force worked in jobs with potential exposure to vinyl chloride monomer. Among the total cohort, statistically significant excess risks were observed for liver, lung, and brain cancer. For the subcohort of workers exposed to vinyl chloride monomer, the standardized mortality ratio (SMR) for liver cancer was 333. There were no significant excesses of either brain or lung cancer. To investigate dose response, nested case-control studies for liver, brain, and lung cancer were conducted among the total cohort (including the nonexposed). JF - J. OCCUP. MED. AU - Wu, Weiai AU - Steenland, K AU - Brown, D AU - Wells, V AU - Jones, J AU - Schulte, P AU - Halperin, W AD - NIOSH, Industrywide Stud. Branch, Robert A. Taft Lab., Cincinnati, OH 45226-1998, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 518 EP - 523 VL - 31 IS - 6 SN - 0096-1736, 0096-1736 KW - vinyl chloride KW - risks KW - carcinoma KW - man KW - occupational health KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - brain KW - occupational exposure KW - lung KW - liver KW - risk assessment KW - cancer KW - H SI0.8.2:CHEMICALS (CORROSION) KW - H SM10.21:CANCER KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15279998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Cohort+and+case-control+analyses+of+workers+exposed+to+vinyl+chloride%3A+An+update.&rft.au=Wu%2C+Weiai%3BSteenland%2C+K%3BBrown%2C+D%3BWells%2C+V%3BJones%2C+J%3BSchulte%2C+P%3BHalperin%2C+W&rft.aulast=Wu&rft.aufirst=Weiai&rft.date=1989-01-01&rft.volume=31&rft.issue=6&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - occupational exposure; liver; lung; brain; occupational health; risk assessment; cancer; carcinoma; man ER - TY - JOUR T1 - Cardiotoxic effects of the combined use of caffeine and isoproterenol in the minipig. AN - 15265943; 2032019 AB - It would not be unexpected that some patients receiving isoproterenol might have ingested caffeine as an over-the-counter drug or beverage. This study explores the possible interaction between these two drugs. Anesthetized minipigs were injected with 0.5 mg/kg caffeine iv followed by a 10-min infusion of 1 mu g/kg multiplied by min isoproterenol. Heart rate, EKG, respiration, and blood pressure were recorded continuously and the animals were sacrificed at 72 h. The two drugs in combination produced subtle changes in heart rate and blood pressure with significant alteration in the EKG tracing (premature ventricular contractions and extrasystoles). These changes persisted for 8 to 24 h. At autopsy both gross and microscopic lesions were noted in 10 of the 13 minipig hearts receiving the combination of drugs. This was not true of the six minipigs given only caffeine or the eight minipigs receiving only the infusion of isoproterenol. JF - Journal of Toxicology and Environmental Health AU - Vick, J AU - Joseph, X AU - Whitehurst, V AU - Herman, E AU - Balazs, T AD - FDA, Cent. Drug Eval. and Res., 200 C St., S.W., Washington, DC 20204, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 425 EP - 435 VL - 26 IS - 4 SN - 0093-4108, 0093-4108 KW - caffeine KW - isoproterenol KW - heart KW - pigs KW - cardiovascular pathology KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - toxicity KW - X 24120:Food, additives & contaminants KW - H SE4.26:DRUGS AND ALCOHOL KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15265943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Cardiotoxic+effects+of+the+combined+use+of+caffeine+and+isoproterenol+in+the+minipig.&rft.au=Vick%2C+J%3BJoseph%2C+X%3BWhitehurst%2C+V%3BHerman%2C+E%3BBalazs%2C+T&rft.aulast=Vick&rft.aufirst=J&rft.date=1989-01-01&rft.volume=26&rft.issue=4&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - toxicity; cardiovascular pathology; heart ER - TY - JOUR T1 - Occupational exposure to zeranol, an animal growth promoter. AN - 15251464; 2014052 AB - Zeranol (3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2 -benzoxacyclotetradecin-1-one) is a synthetic oestrogenic agent used as an animal growth promoter. The effects of occupational exposure to zeranol in 11 exposed workers from a pelletising plant and 14 non-exposed subjects were assessed. A questionnaire showed that more breast symptoms were reported by male and female plant workers compared with non-exposed subjects, although the difference was not statistically significant. Clinical assessment showed no cases of gynaecomastia in all the male participants. Blood samples analysed by high performance liquid chromatography for zeranol, its precursor zearalenone, and its main metabolites did not show any of these compounds above the laboratory limit of detection. JF - Occupational and Environmental Medicine AU - Aw, T C AU - Smith, AB AU - Stephenson, R L AU - Glueck, C J AD - NIOSH, Cincinnati, OH 45226, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 341 EP - 346 VL - 46 IS - 5 SN - 0007-1072, 0007-1072 KW - zeranol KW - serum levels KW - growth regulators KW - gynecomastia KW - breast KW - man KW - occupational health KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - animals KW - hormones KW - occupational exposure KW - X 24112:Chronic exposure KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15251464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupational+exposure+to+zeranol%2C+an+animal+growth+promoter.&rft.au=Aw%2C+T+C%3BSmith%2C+AB%3BStephenson%2C+R+L%3BGlueck%2C+C+J&rft.aulast=Aw&rft.aufirst=T&rft.date=1989-01-01&rft.volume=46&rft.issue=5&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - occupational exposure; animals; hormones; occupational health; growth regulators; gynecomastia; breast; man ER - TY - JOUR T1 - Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. AN - 15238119; 2002195 AB - A total of 137 volunteers were recruited and tested for neurobehavioural performance before, during, and after a short duration (4 h) exposure to acetone at 250 ppm, methyl ethyl ketone (MEK) at 200 ppm, acetone at 125 ppm with MEK at 100 ppm, or a placebo. The measurements were extracted from two biochemical (venous blood and alveolar breath) tests, four psychomotor (choice reaction time, visual vigilance, dual task (auditory tone discrimination and tracking), memory scanning) tests, one sensorimotor (postural sway) test, and one psychological (profile of mood states (POMS)) test. The exposure to 250 ppm acetone produced small but statistically significant changes in performance from controls in two measures of the auditory tone discrimination task and on the anger hostility scale (men only) of the POMS test. Neither MEK nor the combined acetone/MEK exposures produced statistically significant interpretable results. JF - Occupational and Environmental Medicine AU - Dick, R B AU - Setzer, J V AU - Taylor, B J AU - Shukla, R AD - DHHS., Public Health Serv., Cent. Dis. Control, NIOSH, Cincinnati, OH 45226, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 111 EP - 121 VL - 46 IS - 2 SN - 0007-1072, 0007-1072 KW - acetone KW - neurology KW - methyl ethyl ketone KW - neurological complications KW - behaviour KW - man KW - occupational health KW - Pollution Abstracts; Toxicology Abstracts KW - X 24151:Acute exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15238119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Neurobehavioural+effects+of+short+duration+exposures+to+acetone+and+methyl+ethyl+ketone.&rft.au=Dick%2C+R+B%3BSetzer%2C+J+V%3BTaylor%2C+B+J%3BShukla%2C+R&rft.aulast=Dick&rft.aufirst=R&rft.date=1989-01-01&rft.volume=46&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - occupational health; neurology; neurological complications; man ER - TY - JOUR T1 - A chronic inhalation toxicity study of diesel engine emissions and coal dust, alone and combined. AN - 15235030; 2002176 AB - To evaluate health hazards of diesel engine emissions in underground coal mines, inhalation studies were performed using three species of animals. Gross morphology and histopathology demonstrated that both diesel and coal dust particles are deposited in the lungs and retained in alveolar tissue. Alveolar type II cell hyperplasia and pulmonary lipidosis occurred in rats, being most evident in rats exposed to diesel exhaust alone. There was no evidence of emphysema or chronic bronchitis, and only minimal fibrosis was seen in association with the retained particulate. Both particulates affected the defense mechanisms of the lung. Exposure to coal dust activated responses associated with phagocytosis, whereas exposure to diesel exhaust depressed them. Severity of influenza challenge increased concomitantly with decreased interferon production in diesel-exposed mice. JF - Journal of the American College of Toxicology AU - Lewis, T R AU - Green, FHY AU - Moorman, W J AU - Burg, J R AU - Lynch, D W AD - NIOSH, 4676 Columbia Pkwy, C-23, Cincinnati, OH 45226, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 345 EP - 375 VL - 8 IS - 2 SN - 0730-0913, 0730-0913 KW - coal KW - diesel emission KW - chronic toxicity KW - exhaust emissions KW - petroleum KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - toxicity KW - inhalation KW - animals KW - dust KW - P 0000:AIR POLLUTION KW - H ST2.26:EMISSIONS AND EMISSION CONTROL KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15235030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Toxicology&rft.atitle=A+chronic+inhalation+toxicity+study+of+diesel+engine+emissions+and+coal+dust%2C+alone+and+combined.&rft.au=Lewis%2C+T+R%3BGreen%2C+FHY%3BMoorman%2C+W+J%3BBurg%2C+J+R%3BLynch%2C+D+W&rft.aulast=Lewis&rft.aufirst=T&rft.date=1989-01-01&rft.volume=8&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Toxicology&rft.issn=07300913&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - exhaust emissions; toxicity; dust; petroleum; animals; inhalation ER - TY - PAT T1 - Process for isolation of the B oligomer of pertussis toxin. AN - 15227693; 1999744 AB - A method for dissociating the B oligomer of pertussis toxin from the A subunit of pertussis toxin comprises: incubating pertussis toxin in an aqueous solution comprising sodium phosphate buffer pH 7.0, about 3M urea, and a nucleotide selected from the group consisting of ADP and ATP said nucleotide being from about 1 to about 10 micromolar; applying the incubated solution to a CM-Sepharose column; eluting B oligomer from the column with potassium phosphate buffer containing urea. A method of modifying pertussis toxin comprises adding to said N-ethylmaleimide in an amount sufficient to prevent the B oligomer from reassociated with A subunit of pertussis toxin. AU - Burns, D L AU - Manclark, C R PY - 1989 IS - US Patent 4,845,036 KW - B oligomer dissociation KW - Bordetella pertussis KW - patents KW - pertussis KW - toxins KW - vaccines KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - W 30409:Vaccines KW - W 30050:Patents KW - A 01099:Bacteria and fungi KW - A 01023:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15227693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Process+for+isolation+of+the+B+oligomer+of+pertussis+toxin.&rft.au=Burns%2C+D+L%3BManclark%2C+C+R&rft.aulast=Burns&rft.aufirst=D&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - U.S. Cl. 435/194; Int. Cl. C12N 9/12. N1 - Last updated - 2011-12-12 ER - TY - PAT T1 - Adeno-associated virus as eukaryotic expression vector. AN - 15196304; 1972723 AU - Carter, B J AU - Tratschin, J D PY - 1989 IS - US Patent 4,797,368 KW - adeno-associated virus KW - DNA KW - cloning vectors KW - gene transfer KW - patents KW - Biotechnology and Bioengineering Abstracts KW - W 30114:Cloning vectors KW - W 30050:Patents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15196304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Adeno-associated+virus+as+eukaryotic+expression+vector.&rft.au=Carter%2C+B+J%3BTratschin%2C+J+D&rft.aulast=Carter&rft.aufirst=B&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/320; Int. Cl. C12N 7/00, 15/00, C12P 19/34, 21/00. N1 - Last updated - 2011-12-12 ER - TY - PAT T1 - Reconstituted basement membrane complex with biological activity. AN - 15193704; 1972039 AB - In a cell culture composition promoting the growth and differentiation of neurite and epithelial cells comprising a cell inoculum and a cell growth media, the improvement comprises the addition of a protein extract, said protein extract polymerizing into a rigid stable gel in at least 20 minutes on heating at 24-37 degree C. AU - Kleinman, H K AU - Martin, G R PY - 1989 IS - US Patent 4,829,000 KW - patents KW - basement membranes KW - cell culture KW - media (culture) KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents KW - W 30330:Animals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15193704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Reconstituted+basement+membrane+complex+with+biological+activity.&rft.au=Kleinman%2C+H+K%3BMartin%2C+G+R&rft.aulast=Kleinman&rft.aufirst=H&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/240.23; Int. Cl. C12N 5/00, C12R 1/19. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Monoclonal antibodies to pertussis toxin: Utilization as probes of toxin function. AN - 15174315; 1950634 AB - Six monoclonal antibodies (MAbs) to pertussis toxin (PT) have been generated and characterized. Five of these MAbs (3CX4, 3C4D, 6D11C, 6FX1, and X2X5) interact with determinants on the catalytic subunit (S1) of PT, and one (6DX3) is specific for subunit S4. The MAbs are divided into three groups based upon their ability to neutralize the affects of PT in a Chinese hamster ovary (CHO) cell assay. Three of the MAbs (3CX4, 3C4D and 6D11C) had high neutralization titers, one MAb (6FX1) displayed weak neutralizing activity, and two MAbs (X2X5 and 6DX3) had no neutralizing ability. JF - Hybridoma AU - Kenimer, J G AU - Jin Kim, K AU - Probst, P G AU - Manclark, C R AU - Brustyn, D G AU - Cowell, J L AD - Lab. Cell. Physiol., DBP, OBER, FDA (HFN-865), 8800 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 37 EP - 51 VL - 8 IS - 1 SN - 0272-457X, 0272-457X KW - monoclonal antibodies KW - antigenic determinants KW - probes KW - function KW - toxins KW - pertussis toxin KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - CHO cells KW - J 02822:Biosynthesis and physicochemical properties KW - F 06008:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15174315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hybridoma&rft.atitle=Monoclonal+antibodies+to+pertussis+toxin%3A+Utilization+as+probes+of+toxin+function.&rft.au=Kenimer%2C+J+G%3BJin+Kim%2C+K%3BProbst%2C+P+G%3BManclark%2C+C+R%3BBrustyn%2C+D+G%3BCowell%2C+J+L&rft.aulast=Kenimer&rft.aufirst=J&rft.date=1989-01-01&rft.volume=8&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Hybridoma&rft.issn=0272457X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - CHO cells ER - TY - PAT T1 - Kit for assaying activation of terminal complement cascade. AN - 15155658; 1937744 AU - Sanders, ME AU - Joiner, KA AU - Frank, M M AU - Hammer, CH PY - 1989 IS - US Patent 4,820,635 KW - patents KW - activation analysis KW - terminal complement cascade KW - complement KW - tests KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents KW - W 30507:Diagnostic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15155658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Kit+for+assaying+activation+of+terminal+complement+cascade.&rft.au=Sanders%2C+ME%3BJoiner%2C+KA%3BFrank%2C+M+M%3BHammer%2C+CH&rft.aulast=Sanders&rft.aufirst=ME&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/7; Int. Cl. G01N 33/53. N1 - Last updated - 2011-12-12 ER - TY - PAT T1 - Deletion mutants and monoclonal antibodies against ras proteins. AN - 15155227; 1937690 AB - The author describes monoclonal antibodies which recognize specific regions of ras p21 molecule wherein said regions are involved in GTP-binding, said monoclonal antibodies being selected from the group consisting of M38 (ATCC HB 9158) which recognizes amino acid sequence comprising residues 1-23; M8 (ATCC HB 9158) which recognizes amino acid sequence comprising residues 24-69; M70 (ATCC HB 9158) which recognizes amino acid sequence comprising residues 90-106; M90 (ATCC HB 9158) which recognizes amino acid sequence comprising residues 107-130 M30 (ATCC HB 9158) which recognizes amino acid sequence between residues 131-152; and a combination thereof. AU - Lacal, J C AU - Aaronson, SA PY - 1989 IS - US Patent 4,820,631 KW - patents KW - amino acid sequence KW - deletion mutants KW - monoclonal antibodies KW - ras protein KW - Biotechnology and Bioengineering Abstracts KW - W 30050:Patents KW - W 30411:Antibodies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15155227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Deletion+mutants+and+monoclonal+antibodies+against+ras+proteins.&rft.au=Lacal%2C+J+C%3BAaronson%2C+SA&rft.aulast=Lacal&rft.aufirst=J&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - US Cl. 435/6; Int. Cl. C12Q 1/68, G01N 33/53, 33/577, C12N 5/00. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Shellfish sanitation challenges in the 1990's AN - 13750201; 199001914 AB - A discussion of the relationship between water quality control and food safety standards to protect the public from infected shellfish is presented. The alternative approaches to such safety, through ensuring a water of such quality that shellfish contamination could not occur, or bacterially tested commercially harvested shellfish before they were sold, are considered. Difficulties in the formulation of a product standard to cover all types of shellfish are enumerated, as a background to the preferred approach to consumer safety through improved water quality. The need for a strong enforcement agency, with the funds required to collect and analyse data frequently, and for close co-operation between it and any other agencies that might be involved in fisheries management in general, is emphasized. Ways in which shellfish harvesting might be managed, to take advantage of periods of low water pollution when discharges were at a low level and/or when hydrodynamic conditions were favourable, are reviewed. One factor expected to operate to increasing advantage in the future was the greater public awareness of environmental quality needs, and of the scope for the publicity media to exert pressure on governments to initiate, fulfil and be publicly accountable for actions to correct past and present shortcomings in this field. JF - Water Quality Bulletin AU - Schwalm, D J AD - U.S. Food and Drug Administration, Washington, D.C. Y1 - 1989 PY - 1989 DA - 1989 SP - 205 EP - 208 VL - 14 IS - 4 KW - Media KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13750201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Quality+Bulletin&rft.atitle=Shellfish+sanitation+challenges+in+the+1990%27s&rft.au=Schwalm%2C+D+J&rft.aulast=Schwalm&rft.aufirst=D&rft.date=1989-01-01&rft.volume=14&rft.issue=4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Water+Quality+Bulletin&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER -