TY  - JOUR
T1  - Addressing service delivery in remote/rural areas.
AN  - 85172709; pmid-2643949
JF  - ASHA
AU  - Chezik, Kathryn H
AU  - Pratt, J E
AU  - Stewart, J L
AU  - Deal, V R
AD  - Department of Communication Disorders, College of Health Professions, Marshall University; Sensory Disabilities Program, Indian Health Service-Headquarters West, Albuquerque, New Mexico.
PY  - 1989
SP  - 52
EP  - 55
VL  - 31
IS  - 1
SN  - 0001-2475, 0001-2475
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LA  - English
DB  - ComDisDome
N1  - Last updated - 2010-05-07
ER  - 



TY  - JOUR
T1  - Differential phosphate labeling of stress protein polypeptides in toxic dose response during S-phase of mouse lymphoma cells: a micro-electrophoretic study.
AN  - 79572598; 2488592
AB  - Following dosing with various levels of sodium arsenite (NaAsO2), differential [32P]-incorporation (turnover) of polypeptide fragments, generated by protease V8, from a set of four closely related stress proteins (SPs), termed 'c','b','x' and 'y', (80,000-84,000 Mr) was investigated by polyacrylamide gel (PAG) autoradiography. These SPs were physically sorted sequentially from five partitions of S-phase of a mouse lymphoma cell line (YAC-1). The fragments of each of the four SPs exhibited differential [32P]-incorporation patterns with progression in S-phase following varied dose levels of NaAsO2. The majority of V8 protease-fragments of the four SPs had identical electrophoretic mobilities. A minority of polypeptides showed varied distribution among the four SPs and these fragments revealed increased [32P]-labeling progressively in S-phase. These fragments were the most sensitive to altered dose levels of NaAsO2. It was suggested that these four SPs are discrete but structurally similar proteins. A group of other SPs (S1, S2 and S3) observed predominantly in S-phase, showed reduction in polypeptide labeling during S with varied dosing of NaAsO2. The [32P]-labeling of fragments from the SPs seems generally to follow an ordered scheme of turnover (phosphorylation-dephosphorylation) during S-phase.
JF  - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society
AU  - Pipkin, J L
AU  - Anson, J F
AU  - Hinson, W G
AU  - Burns, E R
AU  - Casciano, D A
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 77
EP  - 84
VL  - 1
IS  - 2
SN  - 0954-6642, 0954-6642
KW  - Arsenites
KW  - 0
KW  - Biomarkers
KW  - Heat-Shock Proteins
KW  - Phosphorus Radioisotopes
KW  - Sodium Compounds
KW  - sodium arsenite
KW  - 48OVY2OC72
KW  - DNA
KW  - 9007-49-2
KW  - Arsenic
KW  - N712M78A8G
KW  - Index Medicus
KW  - Animals
KW  - Electrophoresis, Polyacrylamide Gel
KW  - Arsenic -- pharmacology
KW  - Cell Nucleus -- chemistry
KW  - DNA -- analysis
KW  - Cell Nucleus -- drug effects
KW  - Mice
KW  - Autoradiography
KW  - Hydrolysis
KW  - Molecular Weight
KW  - Tumor Cells, Cultured
KW  - Phosphorylation
KW  - Heat-Shock Proteins -- analysis
KW  - S Phase
KW  - Lymphoma -- chemistry
KW  - Heat-Shock Proteins -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.atitle=Differential+phosphate+labeling+of+stress+protein+polypeptides+in+toxic+dose+response+during+S-phase+of+mouse+lymphoma+cells%3A+a+micro-electrophoretic+study.&rft.au=Pipkin%2C+J+L%3BAnson%2C+J+F%3BHinson%2C+W+G%3BBurns%2C+E+R%3BCasciano%2C+D+A&rft.aulast=Pipkin&rft.aufirst=J&rft.date=1989-01-01&rft.volume=1&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Applied+and+theoretical+electrophoresis+%3A+the+official+journal+of+the+International+Electrophoresis+Society&rft.issn=09546642&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1991-05-06
N1  - Date created - 1991-05-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Differential [32P]-labeling of chemically induced stress proteins in S-phase mouse lymphoma cells.
AN  - 79571057; 2488593
AB  - A portion of our research involves the investigation of biomarkers as preclinical indicators of toxic stress. Stemming from this effort, we report three unique proteins that phosphorylate and synthesize during the S-phase of lymphoma cells following chemical insult. Mouse lymphoma cell nuclei were physically sorted (using a fluorescence activated cell sorter) from partitions of the cell cycle and specific nuclear proteins in each partition were examined by gel microelectrophoresis. The changes in [32P]-incorporation by stress proteins (SPs) were examined in each of seven partitions following administration of sodium arsenite. Four SPs [80,000-84,000 relative molecular mass (Mr)], designated 'c','b','x', and 'y', underwent significant alterations in [32P]-labeling and each exhibited varying degrees of differential [32P]-incorporation in partition 3 of G1 phase, all five partitions of S-phase, and partition 1 of G2 phase of the cell cycle. Three other predominantly S-phase SPs (designated S1, S2 and S3) were phosphorylated after sodium arsenite treatment. Stress protein S1 was labeled exclusively in S-phase, while proteins S2 and S3 were labeled only in partition 3 of G1 and S-phase. Stress protein S1 possessed an identical isoelectric point, molecular mass, distribution of polypeptide fragments and immunochemical determinants as S-phase SPs found previously in mouse spleen (X') and mouse liver (LP-S). The identical biochemical characteristics of these three S-phase (SPs), found in diverse tissue types, suggest they are homologous.
JF  - Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society
AU  - Pipkin, J L
AU  - Anson, J F
AU  - Hinson, W G
AU  - Burns, E R
AU  - Casciano, D A
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 85
EP  - 94
VL  - 1
IS  - 2
SN  - 0954-6642, 0954-6642
KW  - Arsenites
KW  - 0
KW  - Heat-Shock Proteins
KW  - Nuclear Proteins
KW  - Phosphorus Radioisotopes
KW  - Sodium Compounds
KW  - Concanavalin A
KW  - 11028-71-0
KW  - sodium arsenite
KW  - 48OVY2OC72
KW  - Isoproterenol
KW  - L628TT009W
KW  - Arsenic
KW  - N712M78A8G
KW  - Phenobarbital
KW  - YQE403BP4D
KW  - Index Medicus
KW  - Spleen -- chemistry
KW  - Animals
KW  - Peptide Mapping
KW  - Arsenic -- pharmacology
KW  - Cell Nucleus -- chemistry
KW  - Isoelectric Point
KW  - Cell Nucleus -- drug effects
KW  - Mice
KW  - Liver -- chemistry
KW  - Isoproterenol -- pharmacology
KW  - Molecular Weight
KW  - Phenobarbital -- pharmacology
KW  - Tumor Cells, Cultured
KW  - Liver -- drug effects
KW  - Electrophoresis, Gel, Two-Dimensional
KW  - Nuclear Proteins -- metabolism
KW  - Concanavalin A -- pharmacology
KW  - Heat-Shock Proteins -- analysis
KW  - S Phase
KW  - Lymphoma -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1991-05-06
N1  - Date created - 1991-05-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Personal service workers: a critical link in the AIDS education chain?
AN  - 79550722; 2641217
AB  - Based on the hepatitis B experience in these PSW occupations, it is possible to transmit HIV through instruments, materials, and equipment used by PSWs. However, PSWs include a group of people that may be overlooked when planning and conducting AIDS education programs because they do not fit into a well defined and apparent risk category as other health care workers. Educators should be cognizant of the need to address this issue in terms of prevention of HIV transmission and proper infection control procedures for PSWs. Educational programs need to be tailored to specific PSW occupations because of their occupational differences. Concern for the potential transmission of HIV through acupuncture, electrology, tattooing, and cosmetology is evident at local, state, and national levels. Anecdotal stories have reported clients purchasing their own electrolysis and acupuncture needles and combs and scissors. Barber shops have declined to shave clients because of their concern over HIV transmission. PSWs need to be concerned with reducing the potential to transmit all infectious diseases, including hepatitis B and HIV. In the current climate of "AIDS phobia," PSWs need to be able to assure their clients that they can provide valued personal services in a safe manner.
JF  - AIDS education and prevention : official publication of the International Society for AIDS Education
AU  - Backinger, C
AD  - Department of Health and Human Services, Public Health Service, Food & Drug Administration, Rockville, MD 20857.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 31
EP  - 38
VL  - 1
IS  - 1
SN  - 0899-9546, 0899-9546
KW  - Index Medicus
KW  - AIDS/HIV
KW  - Needles -- standards
KW  - Acupuncture Therapy
KW  - Humans
KW  - Electrolysis
KW  - Beauty Culture
KW  - HIV Infections -- transmission
KW  - Occupational Diseases -- prevention & control
KW  - HIV Infections -- prevention & control
KW  - Health Education
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+J.M.+Foundation%3A+Mainstreaming+Alcohol+and+Drug+Issues+in+American+Medicine&rft.au=Dolan%2C+Joseph+S&rft.aulast=Dolan&rft.aufirst=Joseph&rft.date=1989-01-01&rft.volume=13&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1990-09-26
N1  - Date created - 1990-09-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Occupational safety and health standards.
AN  - 79484237; 2697168
AB  - If we are to approach developing a safe and healthful workplace in a more timely fashion, a more generic approach must be considered and applied instead of developing recommendations and standards simply on a substance-by-substance basis, an approach that has been the most prominent. Some examples in which developing generic standards may be appropriate are: cholinesterase-inhibiting substances, neurotoxic agents, reproductive hazards, cold environments, and vibration syndrome, to name but a few. It is important to recognize that developing standards based on individual substances often does not allow for the role of synergism, a reaction that has had little study, but it is important in controlling occupational disease and injury. These concerns can be addressed in several ways. One is to look at processes or conditions found in the workplace; for example, coke oven emissions that OSHA has promulgated into a standard and, as NIOSH has done in their recommendations to OSHA for foundries, coal tar products, the manufacture of paint and allied coatings, field sanitation, hazardous waste management, hot environments, and confined spaces. Another is to address groups of similar substances such as NIOSH has done with alkanes, benzidine-based dyes, diisocyanates, dinitrotoluenes, and glycol ethers. A third comprehensive approach is to look at general categories of hazards, such as the generic carcinogen policy, and the hazard communication rule. Finally, risk must be considered in the development of any standard. Nelson Rockefeller once said in relation to an incidence involving a radiation hazard that, "you can't have a riskless society." I would amend this to say that you cannot have a reckless society either. Safety and health regulations are essential and must be designed, promulgated, and then enforced so that a reckless society is avoided or controlled, with a riskless society being the ultimate aim.
JF  - Annals of the New York Academy of Sciences
AU  - Lemen, R A
AU  - Mazzuckelli, L F
AU  - Niemeier, R W
AU  - Ahlers, H W
AD  - National Institute for Occupational Safety and Health, U.S. Department of Health and Human Services, Cincinnati, Ohio 45226.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 100
EP  - 6; discussion 107-9
VL  - 572
SN  - 0077-8923, 0077-8923
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Occupational Diseases -- prevention & control
KW  - Occupational Medicine -- standards
KW  - United States Occupational Safety and Health Administration
KW  - Occupational Medicine -- legislation & jurisprudence
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1990-04-12
N1  - Date created - 1990-04-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Worker-notification activities at the National Institute for Occupational Safety and Health. Past and present.
AN  - 79483531; 2627072
JF  - Annals of the New York Academy of Sciences
AU  - Baker, E L
AU  - Schulte, P A
AU  - French, J G
AD  - National Institute for Occupational Safety and Health, CDC Atlanta, Georgia 30333.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 144
EP  - 50; discussion 163-5
VL  - 572
SN  - 0077-8923, 0077-8923
KW  - Index Medicus
KW  - Risk Factors
KW  - Humans
KW  - Cohort Studies
KW  - Pilot Projects
KW  - United States -- epidemiology
KW  - National Institutes of Health (U.S.)
KW  - Occupational Diseases -- etiology
KW  - Environmental Exposure
KW  - Occupational Diseases -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1990-04-12
N1  - Date created - 1990-04-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The right to know in the workplace. The moral dimension.
AN  - 79483478; 2627067
AB  - The makers of public policy cannot avoid the deep and often strident public controversy over the nature and scope of basic moral rights. There are persuasive defenders on both sides of the issue. Forging public policy in the absence of a broad public consensus is nothing more than the arbitrary imposition by government of some preferred, but not necessarily privileged, moral view. It hardly seems the legitimate role of a democratic government, even in the name of moral leadership, to so impose views that are deeply controversial and not capable of broad-based support by the population at large. It is better by far, for reasons of stable public policy, that we seek the painful path of building a general public consensus among the well-informed and well-meaning citizenry. If no such consensus can be achieved, then the law will, as a matter of necessity, settle the issue in the interest of the efficient discharge of general social functions. . .and that is really not a particularly unfortunate outcome.
JF  - Annals of the New York Academy of Sciences
AU  - Millar, J D
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia 30333.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 113
EP  - 21; disc. 121-3, 142-3
VL  - 572
SN  - 0077-8923, 0077-8923
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Occupational Medicine -- legislation & jurisprudence
KW  - Philosophy
KW  - Morals
KW  - Environmental Exposure
KW  - Consumer Advocacy
KW  - Occupational Diseases
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1990-04-12
N1  - Date created - 1990-04-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
AN  - 79202376; 2773945
AB  - Review of employment and chemical production records at a Missouri chemical plant and of questionnaires with self-reported occupational exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin (2,3,7,8-TCDD) for 16 Missouri workers has explained the wide diversity of 2,3,7,8-TCDD levels previously reported in the workers' adipose tissue (3.5-750 ppt on whole-weight basis). We show that the highest exposures reported to date in the United States occurred in a group of nine production workers who made products contaminated with 2,3,7,8-TCDD. The nine workers had adipose tissue levels with a mean of 246 ppt and a range of 42 to 750 ppt. Seven persons who worked at the same chemical company, but not in the 2,3,7,8-TCDD-contaminated process, had a mean of 8.7 ppt and a range of 3.5 to 25.8 ppt. We also report serum levels of 2,3,7,8-TCDD in these individuals. The adipose tissue from a subset of four production workers with elevated levels of 2,3,7,8-TCDD and seven Missouri residents with normal 2,3,7,8-TCDD levels was also analyzed for other isomers of the PCDDs and PCDFs. The mean adipose tissue level of 2,3,7,8-TCDD in the subset of production workers was 45 times higher than the mean level in the unexposed Missouri residents, but similar levels of the other PCDDs and PCDFs were found in both groups.
JF  - American journal of industrial medicine
AU  - Patterson, D G
AU  - Fingerhut, M A
AU  - Roberts, D W
AU  - Needham, L L
AU  - Sweeney, M H
AU  - Marlow, D A
AU  - Andrews, J S
AU  - Halperin, W E
AD  - Center for Environmental health and Injury Control, U.S. Department of Health and Human Services, Atlanta, GA 30333.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 135
EP  - 146
VL  - 16
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Benzofurans
KW  - 0
KW  - Dibenzofurans, Polychlorinated
KW  - Dioxins
KW  - Polychlorinated Dibenzodioxins
KW  - Index Medicus
KW  - Missouri
KW  - Humans
KW  - Male
KW  - Female
KW  - Chemical Industry
KW  - Polychlorinated Dibenzodioxins -- analogs & derivatives
KW  - Dioxins -- adverse effects
KW  - Polychlorinated Dibenzodioxins -- analysis
KW  - Occupational Diseases -- metabolism
KW  - Dioxins -- analysis
KW  - Adipose Tissue -- analysis
KW  - Polychlorinated Dibenzodioxins -- adverse effects
KW  - Benzofurans -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Levels+of+polychlorinated+dibenzo-p-dioxins+and+dibenzofurans+in+workers+exposed+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin.&rft.au=Patterson%2C+D+G%3BFingerhut%2C+M+A%3BRoberts%2C+D+W%3BNeedham%2C+L+L%3BSweeney%2C+M+H%3BMarlow%2C+D+A%3BAndrews%2C+J+S%3BHalperin%2C+W+E&rft.aulast=Patterson&rft.aufirst=D&rft.date=1989-01-01&rft.volume=16&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-09-27
N1  - Date created - 1989-09-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Lead exposure among lead-acid battery workers in Jamaica.
AN  - 79199221; 2773946
AB  - To assess lead exposure in the Jamaican lead-acid battery industry, we surveyed three battery manufacturers (including 46 production workers) and 10 battery repair shops (including 23 battery repair workers). Engineering controls and respiratory protection were judged to be inadequate at battery manufacturers and battery repair shops. At manufacturers, 38 of 42 air samples for lead exceeded a work-shift time-weighted average concentration of 0.050 mg/m3 (range 0.030-5.3 mg/m3), and nine samples exceeded 0.50 mg/m3. Only one of seven air samples at repair shops exceeded 0.050 mg/m3 (range 0.003-0.066 mg/m3). Repair shop workers, however, had higher blood lead levels than manufacturing workers (65% vs. 28% with blood lead levels above 60 micrograms/dl, respectively). Manufacturing workers had a higher prevalence of safe hygienic practices and a recent interval of minimal production had occurred at one of the battery manufacturers. Workers with blood lead levels above 60 micrograms/dl tended to have higher prevalences of most symptoms of lead toxicity than did workers with lower blood lead levels, but this finding was not consistent or statistically significant. The relationship between zinc protoporphyrin concentrations and increasing blood lead concentrations was consistent with that described among workers in developed countries. The high risk of lead toxicity among Jamaican battery workers is consistent with studies of battery workers in other developing countries.
JF  - American journal of industrial medicine
AU  - Matte, T D
AU  - Figueroa, J P
AU  - Burr, G
AU  - Flesch, J P
AU  - Keenlyside, R A
AU  - Baker, E L
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, GA 30333.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 167
EP  - 177
VL  - 16
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Lead
KW  - 2P299V784P
KW  - Index Medicus
KW  - Electric Power Supplies
KW  - Air Pollutants, Occupational -- analysis
KW  - Risk Factors
KW  - Humans
KW  - Adult
KW  - Jamaica
KW  - Male
KW  - Occupational Diseases -- epidemiology
KW  - Lead Poisoning -- epidemiology
KW  - Developing Countries
KW  - Occupational Diseases -- chemically induced
KW  - Lead -- blood
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199221?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Lead+exposure+among+lead-acid+battery+workers+in+Jamaica.&rft.au=Matte%2C+T+D%3BFigueroa%2C+J+P%3BBurr%2C+G%3BFlesch%2C+J+P%3BKeenlyside%2C+R+A%3BBaker%2C+E+L&rft.aulast=Matte&rft.aufirst=T&rft.date=1989-01-01&rft.volume=16&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-09-27
N1  - Date created - 1989-09-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The role of arachidonic acid metabolites in mediating ethanol self-administration and intoxication.
AN  - 79198575; 2774408
AB  - Prostaglandin synthesis inhibitors antagonize the effects of alcohols, indicating that some aspect of cyclooxygenase activity and arachidonic acid metabolism is involved in the mechanism of action of alcohols. In addition, ethanol increases in vivo brain PGE and PGF levels in a manner correlated across dose and time with the absorption phase of ethanol. These results have provided systematic evidence in support of the hypothesis that ethanol produces its intoxicating effects to a significant degree through a prostaglandin-mediated mechanism. This report has presented an overview of this work, as well as additional results from a series of recent studies that examined the effects of pretreatment with INDO, a potent PGSI, on ethanol self-administration. The results of these self-administration studies indicate that INDO can decrease responding for ethanol in a dose-related manner. The pattern of changes suggests that INDO decreases ethanol self-administration by decreasing the reinforcing effects of ethanol and not by producing a conditioned aversion to ethanol. In a subsequent study, INDO did not affect saccharin self-administration. These results suggest that there exists a common prostaglandin-related mechanism that is important in the mediation of both acute sensitivity to ethanol and the reinforcing properties of this drug. These findings may provide for the development of novel pharmaceutical treatments for acute alcohol overdose as well as for chronic alcohol abuse.
JF  - Annals of the New York Academy of Sciences
AU  - George, F R
AD  - National Institute on Drug Abuse, United States Department of Health and Human Services, Baltimore, Maryland 22124.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 382
EP  - 391
VL  - 559
SN  - 0077-8923, 0077-8923
KW  - Arachidonic Acids
KW  - 0
KW  - Ethanol
KW  - 3K9958V90M
KW  - Saccharin
KW  - FST467XS7D
KW  - Indomethacin
KW  - XXE1CET956
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Male
KW  - Ethanol -- blood
KW  - Self Administration
KW  - Alcoholic Intoxication
KW  - Ethanol -- administration & dosage
KW  - Arachidonic Acids -- physiology
KW  - Indomethacin -- pharmacology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79198575?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=The+role+of+arachidonic+acid+metabolites+in+mediating+ethanol+self-administration+and+intoxication.&rft.au=George%2C+F+R&rft.aulast=George&rft.aufirst=F&rft.date=1989-01-01&rft.volume=559&rft.issue=&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-10-03
N1  - Date created - 1989-10-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Medical-examiner-reported fatal occupational injuries, North Carolina, 1978-1984.
AN  - 79092916; 2750742
AB  - Fatal occupational injuries are a major public health problem in the U.S. Utilizing a medical examiner database from North Carolina, 1,233 fatal work-related injuries were identified in a 7-year time period. Twelve percent of these deaths were in out-of-state residents. For men, highest risk industries were forestry/fishery, agriculture, trade, and transportation/public utilities/communications. Only 4% of deaths occurred in women. The most common manner of death in women was homicide. Highest-risk industries for women were agriculture, trade, and transportation/public utilities/communications. Of 902 decedents tested, alcohol was found in 11%, and 7% had levels at or above 100 mg%. Because of its completeness, the North Carolina Medical Examiner System is a useful tool to use in the surveillance of fatal occupational injuries.
JF  - American journal of industrial medicine
AU  - Sniezek, J E
AU  - Horiagon, T M
AD  - National Institute for Occupational Safety and Health, Department of Health and Human Services, Atlanta, Georgia.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 669
EP  - 678
VL  - 15
IS  - 6
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - Information Systems
KW  - Age Factors
KW  - Sex Factors
KW  - Humans
KW  - Aged
KW  - Cause of Death
KW  - Homicide
KW  - Coroners and Medical Examiners
KW  - Risk Factors
KW  - North Carolina
KW  - Adult
KW  - Middle Aged
KW  - Adolescent
KW  - Female
KW  - Male
KW  - Accidents, Occupational -- mortality
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79092916?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Medical-examiner-reported+fatal+occupational+injuries%2C+North+Carolina%2C+1978-1984.&rft.au=Sniezek%2C+J+E%3BHoriagon%2C+T+M&rft.aulast=Sniezek&rft.aufirst=J&rft.date=1989-01-01&rft.volume=15&rft.issue=6&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-08-15
N1  - Date created - 1989-08-15
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
Am J Ind Med. 1990;17(4):531, 533 [2327418]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neurobehavioral effects of prenatal caffeine.
AN  - 79065184; 2662862
JF  - Annals of the New York Academy of Sciences
AU  - Sobotka, T J
AD  - Division of Toxicological Studies, Food and Drug Administration, Washington, DC 20204.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 327
EP  - 339
VL  - 562
SN  - 0077-8923, 0077-8923
KW  - Caffeine
KW  - 3G6A5W338E
KW  - Index Medicus
KW  - Rats
KW  - Behavior, Animal -- drug effects
KW  - Animals
KW  - Humans
KW  - Nervous System -- drug effects
KW  - Nervous System -- growth & development
KW  - Mice
KW  - Female
KW  - Pregnancy
KW  - Caffeine -- administration & dosage
KW  - Caffeine -- toxicity
KW  - Prenatal Exposure Delayed Effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79065184?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Neurobehavioral+effects+of+prenatal+caffeine.&rft.au=Sobotka%2C+T+J&rft.aulast=Sobotka&rft.aufirst=T&rft.date=1989-01-01&rft.volume=562&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-07-28
N1  - Date created - 1989-07-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Acute airway narrowing in monkeys from challenge with 2.5 ppm formaldehyde generated from formalin.
AN  - 78861419; 2644895
AB  - Nine adult male Cynomolgus monkeys (Macaca fascicularis) were exposed for 10 min to 2.55 +/- 0.03 ppm formaldehyde (HCHO; mean +/- standard error of the mean, SEM) generated from formalin with a newly developed HCHO challenge system. The generation system was capable of producing highly stable HCHO vapor concentrations with fluctuations of HCHO concentrations of less than +/- 5%. The experimental design included pre-exposure methacholine challenge to determine if responses to HCHO were associated with pre-existing bronchial hyperreactivity. Significant changes in average pulmonary flow resistance (RL) were observed (compared to control RL values) at 2 (p less than 0.01), 5 (p less than 0.01), and 10 min (p less than 0.005) post-HCHO challenge. Pre-challenge RL values (mean +/- SEM) were 11.3 +/- 1.4 cm H2O.l/s, while at 2, 5, and 10 min after HCHO challenge, values were 16.1 +/- 2.1, 16.9 +/- 2.8 and 20.0 +/- 3.4 cm H2O.l/s, respectively. Methacholine challenge data suggest that reactions to HCHO tend to be greater in monkeys hyperreactive to methacholine, but the relationship does not reach statistical significance in this small series of animals. These data indicate that significant pulmonary function deficits occur immediately after challenge with 2.55 ppm HCHO vapor in monkeys.
JF  - Archives of environmental health
AU  - Biagini, R E
AU  - Moorman, W J
AU  - Knecht, E A
AU  - Clark, J C
AU  - Bernstein, I L
AD  - Department of Health and Human Services, Centers for Disease Control, Cincinnati, Ohio.
PY  - 1989
SP  - 12
EP  - 17
VL  - 44
IS  - 1
SN  - 0003-9896, 0003-9896
KW  - Methacholine Compounds
KW  - 0
KW  - Methacholine Chloride
KW  - 0W5ETF9M2K
KW  - Formaldehyde
KW  - 1HG84L3525
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Animals
KW  - Macaca fascicularis
KW  - Drug Hypersensitivity -- physiopathology
KW  - Bronchial Provocation Tests
KW  - Pulmonary Ventilation -- drug effects
KW  - Administration, Inhalation
KW  - Lung Volume Measurements
KW  - Male
KW  - Drug Hypersensitivity -- diagnosis
KW  - Airway Resistance -- drug effects
KW  - Formaldehyde -- toxicity
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78861419?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Double+Trouble%3A+Alcohol+and+Other+Drug+Use+Among+Orthopedically+Impaired+College+Students&rft.au=Moore%2C+Dennis%3BSiegal%2C+Harvey&rft.aulast=Moore&rft.aufirst=Dennis&rft.date=1989-01-01&rft.volume=13&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-15
N1  - Date created - 1989-03-15
N1  - Date revised - 2017-01-14
N1  - Last updated - 2017-01-19
ER  - 



TY  - JOUR
T1  - A computer program for incidence density sampling of controls in case-control studies nested within occupational cohort studies.
AN  - 78811652; 2910063
AB  - A nested case-control study is a case-control study performed with a cohort study. The nested case-control design is useful because the number of study subjects for whom risk factor information is needed is smaller than in the original cohort study. The approach is especially helpful when collection of data is expensive or time consuming, as when it is necessary to contact subjects or next of kin. Selection of controls in nested case-control studies is best performed with a method called "incidence density" sampling. An approach to incidence density sampling that yields a valid estimate of the rate ratio is sampling without replacement from noncases at the time of case occurrence. To implement this approach, a system of computer programs was written that randomly selects a user defined number of controls for each case. The case-control data produced by this program can be analyzed by conditional logistic regression.
JF  - American journal of epidemiology
AU  - Beaumont, J J
AU  - Steenland, K
AU  - Minton, A
AU  - Meyer, S
AD  - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH.
Y1  - 1989/01//
PY  - 1989
DA  - January 1989
SP  - 212
EP  - 219
VL  - 129
IS  - 1
SN  - 0002-9262, 0002-9262
KW  - Index Medicus
KW  - Prospective Studies
KW  - Risk Factors
KW  - Humans
KW  - Cohort Studies
KW  - Retrospective Studies
KW  - Mathematical Computing
KW  - Software
KW  - Epidemiologic Methods
KW  - Occupational Diseases -- epidemiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78811652?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=A+computer+program+for+incidence+density+sampling+of+controls+in+case-control+studies+nested+within+occupational+cohort+studies.&rft.au=Beaumont%2C+J+J%3BSteenland%2C+K%3BMinton%2C+A%3BMeyer%2C+S&rft.aulast=Beaumont&rft.aufirst=J&rft.date=1989-01-01&rft.volume=129&rft.issue=1&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-02-01
N1  - Date created - 1989-02-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Capillary supercritical fluid chromatography/negative ion chemical ionization mass spectrometry of trichothecenes.
AN  - 76291332; 2706372
AB  - A capillary supercritical fluid chromatography/mass spectrometry interface incorporating a heated frit restrictor is described. The trichothecene mycotoxins T-2 toxin, deoxynivalenol and roridin A were used to evaluate the effect of restrictor temperature and carbon dioxide mobile phase on the negative ion chemical ionization (CI) spectra of these compounds under electron capture, proton abstraction and chloride attachment conditions. Restrictor temperatures less than 100 degrees C above the melting point of the samples retarded sample transfer into the mass spectrometer, but neither restrictor temperature nor carbon dioxide mobile phase significantly affected negative ion CI conditions.
JF  - Biomedical & environmental mass spectrometry
AU  - Roach, J A
AU  - Sphon, J A
AU  - Easterling, J A
AU  - Calvey, E M
AD  - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.
Y1  - 1989/01//
PY  - 1989
DA  - January 1989
SP  - 64
EP  - 70
VL  - 18
IS  - 1
SN  - 0887-6134, 0887-6134
KW  - Anti-Bacterial Agents
KW  - 0
KW  - Mycotoxins
KW  - Sesquiterpenes
KW  - Trichothecenes
KW  - roridin A
KW  - 14729-29-4
KW  - deoxynivalenol
KW  - JT37HYP23V
KW  - Index Medicus
KW  - Gas Chromatography-Mass Spectrometry -- methods
KW  - Gas Chromatography-Mass Spectrometry -- instrumentation
KW  - Anti-Bacterial Agents -- analysis
KW  - Mycotoxins -- analysis
KW  - Trichothecenes -- analysis
KW  - Sesquiterpenes -- analysis
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76291332?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+%26+environmental+mass+spectrometry&rft.atitle=Capillary+supercritical+fluid+chromatography%2Fnegative+ion+chemical+ionization+mass+spectrometry+of+trichothecenes.&rft.au=Roach%2C+J+A%3BSphon%2C+J+A%3BEasterling%2C+J+A%3BCalvey%2C+E+M&rft.aulast=Roach&rft.aufirst=J&rft.date=1989-01-01&rft.volume=18&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Biomedical+%26+environmental+mass+spectrometry&rft.issn=08876134&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-06-06
N1  - Date created - 1989-06-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - BOOK
T1  - Surgeon general's workshop on drunk driving: proceedings, Washington, D.C., December 14-16, 1988
AN  - 59522250; 1990-0407873
AB  - Includes recommendations and strategies to alleviate the problem. Partial contents: Epidemiology and data management; Education; Law enforcement; Treatment; Citizen advocacy.
JF  - 5600 Fishers Lane, Rockville, MD 20857, 1989. xi+106 pp.
Y1  - 1989///0,
PY  - 1989
DA  - 0, 1989
EP  - xi+106
PB  - 5600 Fishers Lane, Rockville, MD 20857
KW  - Public health -- United States
KW  - Drinking and traffic accidents -- Conferences
KW  - Motor vehicle drivers -- Liquor problem -- Conferences
KW  - United States -- Surgeon general
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59522250?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=xi%2B106&rft.isbn=&rft.btitle=Surgeon+general%27s+workshop+on+drunk+driving%3A+proceedings%2C+Washington%2C+D.C.%2C+December+14-16%2C+1988&rft.title=Surgeon+general%27s+workshop+on+drunk+driving%3A+proceedings%2C+Washington%2C+D.C.%2C+December+14-16%2C+1988&rft.issn=&rft_id=info:doi/
LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - 5600 Fishers Lane, Rockville, MD 20857 pa
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Biotechnology facility requirements, part I. Facility and systems design.
AN  - 16064558; 2621131
JF  - BioPharm
AU  - Hill, D
AU  - Beatrice, M
AD  - Div. Prod. Certif., Cent. Biol. Eval. and Res., FDA, HFB-240, 8800 Rockville Pike, Bethesda, MD 20205, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 20
EP  - 26
VL  - 2
IS  - 9
SN  - 1040-8304, 1040-8304
KW  - biotechnology
KW  - design
KW  - industrial sites
KW  - laboratories
KW  - legislation
KW  - safety regulations
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30000:General topics and reviews
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16064558?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioPharm&rft.atitle=Biotechnology+facility+requirements%2C+part+I.+Facility+and+systems+design.&rft.au=Hill%2C+D%3BBeatrice%2C+M&rft.aulast=Hill&rft.aufirst=D&rft.date=1989-01-01&rft.volume=2&rft.issue=9&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=BioPharm&rft.issn=10408304&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - Picogram level quantitation of 2,3,7,8-tetrachlorodibenzo-p-dioxin in fish extracts by capillary gas chromatography/matrix isolation/fourier transform infrared spectrometry.
AN  - 15912046; 2497751
AB  - For the first time, gas chromatography/matrix isolation/Fourier transform infrared spectrometry (GC/MI/FTIR) has been reported to confirm the identity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2378-TCDD) and to quantify its level in fish extracts in the 170-220 pg range "on disk". When expressed on a fish tissue basis, analyte levels ranged from 15 to 45 pg/g. Spectroscopic identification was based on the position and relative intensity of seven absorption bands. Optical alignment as well as performance evaluation and optimization of the GC/MI/FTIR system are described. The use of ( super(13)C sub(12))2378-TCDD as an internal standard was essential for quantitation, and quality assurance controls were used to verify system performance. GC/MI/FTIR quantitation of 2378-TCDD was compared with that independently found by GC with electron capture detection.
JF  - Analytical Chemistry
AU  - Mossoba, M M
AU  - Niemann, R A
AU  - Chen, Jo-Yun T
AD  - Div. Contam. Chem., FDA, 200 C St. SW, Washington, DC 20204, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 1678
EP  - 1685
VL  - 61
IS  - 15
SN  - 0003-2700, 0003-2700
KW  - TCDD
KW  - aromatic hydrocarbons
KW  - chemical extraction
KW  - determination
KW  - extracts
KW  - fish
KW  - methodology
KW  - toxicity tests
KW  - ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Toxicology Abstracts
KW  - Pisces
KW  - toxicity
KW  - water pollution
KW  - X 24120:Food, additives & contaminants
KW  - P 2000:FRESHWATER POLLUTION
KW  - X 24222:Analytical procedures
KW  - X 24153:Metabolism
KW  - Q5 08502:Methods and instruments
KW  - X 24133:Metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2015-03-24
N1  - SubjectsTermNotLitGenreText - toxicity; chemical extraction; fish; toxicity tests; water pollution; methodology; aromatic hydrocarbons; Pisces
ER  - 



TY  - BOOK
T1  - Neurobehavioral effects of prenatal caffeine.
AN  - 15906771; 2497486
AB  - Caffeine is a unique chemical in that it is a constituent of both drug preparations and commonly used foods and beverages. The widespread presence of this pharmacologically and behaviorally active compound raises obvious questions about the health consequences of continuous exposure to excessive levels of this chemical. The consequences to the development of the immature organisms are of particular interest, given the fact that caffeine can cross the placenta and reach the fetus. This paper gives an overview and summary of the experimental information pertaining to the neurodevelopmental effects of prenatal exposure to caffeine and highlights areas in which additional information is needed.
JF  - Annals of the New York Academy of Sciences [ANN. N.Y. ACAD. SCI.]. 1989.
AU  - Sobotka, T J
A2  - Hutchings, DE (ed)
Y1  - 1989
PY  - 1989
DA  - 1989
KW  - neurological complications
KW  - prenatal effects
KW  - behaviour
KW  - caffeine
KW  - intrauterine exposure
KW  - neurology
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - prenatal experience
KW  - X 24120:Food, additives & contaminants
KW  - H SE4.26:DRUGS AND ALCOHOL
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15906771?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sobotka%2C+T+J&rft.aulast=Sobotka&rft.aufirst=T&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Neurobehavioral+effects+of+prenatal+caffeine.&rft.title=Neurobehavioral+effects+of+prenatal+caffeine.&rft.issn=00778923&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - Effect of short-term exposure of rats to dehydroepiandrosterone on the hepatic metabolism of dimethylnitrosamine.
AN  - 15864516; 2453435
AB  - The influence of short-term treatment with dehydroepiandrosterone (DHEA), a naturally occurring adrenal steroid, on hepatic metabolism and macromolecular interactions of the hepatocarcinogen dimethylnitrosamine (NDMA) was investigated in male Sprague-Dawley rats. Liver weight, total tissue protein, microsomal and cytosolic proteins and cytochrome P-450 were all significantly increased in rats treated orally with DHEA (300 mg/kg body wt., suspended in 1.0 ml of sesame oil). The hepatic DNA content was not altered. However, methylation of DNA by NDMA was reduced significantly in DHEA-treated rats. The binding of ( super(14)C)NDMA to hepatic proteins was greater in DHEA-treated rats. The results suggest that short-term treatment of rats with DHEA enhances the binding of NDMA-derived metabolites to hepatic proteins, resulting in the protection of DNA from the damaging effects of NDMA.
JF  - Biochemical Journal
AU  - Prasanna, H R
AU  - Hart, R W
AU  - Magee, P N
AD  - DHHS/PHS/FDA (HFT-1), Natl. Cent. Toxicol. Res., Jefferson, AR 72079, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 985
EP  - 988
VL  - 262
IS  - 3
SN  - 0264-6021, 0264-6021
KW  - dehydroepiandrosterone
KW  - effects on
KW  - metabolism
KW  - binding
KW  - N-nitrosodimethylamine
KW  - rats
KW  - Toxicology Abstracts
KW  - liver
KW  - proteins
KW  - X 24200:Nitrosamines & related compounds
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15864516?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Journal&rft.atitle=Effect+of+short-term+exposure+of+rats+to+dehydroepiandrosterone+on+the+hepatic+metabolism+of+dimethylnitrosamine.&rft.au=Prasanna%2C+H+R%3BHart%2C+R+W%3BMagee%2C+P+N&rft.aulast=Prasanna&rft.aufirst=H&rft.date=1989-01-01&rft.volume=262&rft.issue=3&rft.spage=985&rft.isbn=&rft.btitle=&rft.title=Biochemical+Journal&rft.issn=02646021&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - liver; proteins
ER  - 



TY  - JOUR
T1  - Effect of food restriction on the metabolism of dimethylnitrosamine (NDMA) in rats.
AN  - 15786726; 2388377
AB  - The influence of food restriction on the macromolecular interactions of the hepatocarcinogen dimethylnitrosamine (NDMA) in the livers of male Sprague Dawley rats was investigated. Two-three month old rats were food restricted (FR) (40% with respect to ad libitum fed rats) for three weeks. The liver weight, total protein, microsomal and cytoplasmic protein, cytochrome P-450 and DNA content per whole liver were all reduced significantly in food restricted rats. Five hours after a single dose of ( super(14)C) NDMA the levels of 7-methylguanine increased in restricted rats by 32%. Cytochrome P-450 mediated generation of HCHO from NDMA (1.8 fold) in restricted rats was greater. Binding of NDMA derived radioactivity to total hepatic proteins decreased by 46% in restricted rats. These results suggest that food restriction enhances the metabolic activation of dimethyl-nitrosamine in Sprague Dawley rats.
JF  - Anticancer Research
AU  - Prasanna, H R
AU  - Hart, R W
AU  - Magee, P N
AD  - DHHS/PHS/FDA, HFT-1, Natl. Cent. Toxicol. Res., Jefferson, AR 72079, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 93
EP  - 96
VL  - 9
IS  - 1
SN  - 0250-7005, 0250-7005
KW  - N-nitrosodimethylamine
KW  - metabolism
KW  - food restriction
KW  - rats
KW  - Toxicology Abstracts
KW  - X 24200:Nitrosamines & related compounds
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15786726?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=Effect+of+food+restriction+on+the+metabolism+of+dimethylnitrosamine+%28NDMA%29+in+rats.&rft.au=Prasanna%2C+H+R%3BHart%2C+R+W%3BMagee%2C+P+N&rft.aulast=Prasanna&rft.aufirst=H&rft.date=1989-01-01&rft.volume=9&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - Further follow-up and adjustment for smoking in a study of lung cancer and acid mists.
AN  - 15438229; 2175435
AB  - Follow-up of a cohort of 1,165 steelworkers exposed to acid mists has been extended from 1981 to early 1986 for most cohort members, and information on smoking has also been collected. We obtained an SMR for lung cancer (unadjusted for smoking) of 1.56. For those with 20 years or more since first exposure, the SMR was 1.72. However, no trend was found with duration of exposure. To adjust for smoking, we used an indirect adjustment as suggested by Axelson to account for the fact that the exposed cohort smoked slightly more than the U.S. referent population. The SMR for the whole cohort dropped to 1.36, while for those with more than 20 years since first exposure, the SMR was 1.50. These results indicate that an excess risk for lung cancer persists after control for confounding by smoking.
JF  - American Journal of Industrial Medicine
AU  - Steenland, K
AU  - Beaumont, J
AD  - NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 347
EP  - 354
VL  - 16
IS  - 4
SN  - 0271-3586, 0271-3586
KW  - acid mists
KW  - carcinoma
KW  - relationship
KW  - man
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - acids
KW  - lung
KW  - occupational exposure
KW  - cancer
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - H SM10.24:PULMONARY DISEASES
KW  - X 24152:Chronic exposure
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15438229?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Further+follow-up+and+adjustment+for+smoking+in+a+study+of+lung+cancer+and+acid+mists.&rft.au=Steenland%2C+K%3BBeaumont%2C+J&rft.aulast=Steenland&rft.aufirst=K&rft.date=1989-01-01&rft.volume=16&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - lung; occupational exposure; cancer; acids; man
ER  - 



TY  - JOUR
T1  - Biotechnology facility requirements, part II. Operating procedures and validation.
AN  - 15397915; 2146008
AB  - In Part I, we discussed facility and systems design, reviewing some general requirements for facilities for the manufacture of licensed biological products. This article elaborates on some of these concerns, providing insight into the Current Good Manufacturing Practice Regulations for Finished Pharmaceuticals. We also refer the reader to FDA's Points to Consider documents, which provide information about manufacturing and testing recombinant products and therapeutic monoclonals and about methods of characterizing cell lines used to produce biologicals. Other useful documents include FDA Guidelines on Sterile Drug Products Produced by Aseptic Processing and the NIH Guidelines for Research Involving Recombinant DNA Molecules.
JF  - BioPharm
AU  - Hill, D
AU  - Beatrice, M
AD  - Div. Prod. Certif., HFB-240, Cent. Biol. Eval. and Res., FDA, 8800 Rockville Pike, Bethesda, MD 20205, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 28
EP  - 32
VL  - 2
IS  - 10
SN  - 1040-8304, 1040-8304
KW  - reviews
KW  - requirements
KW  - USA
KW  - food and Drug Administration
KW  - facility
KW  - biotechnology
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30000:General topics and reviews
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Investigation of charcoal cloth as a sorbent for integrated sampling of solvent vapors in mixed-expired breath using a new stainless steel sampler.
AN  - 15359354; 2117273
AB  - A stainless steel device for integrated sampling of solvents present in mixed-expired breath is described. During sampling, the subject inhales breathing air through commercial charcoal inhalation canisters. Exhales breath is sampled from the mainstream using 45-mm wafers of charcoal cloth or from the sidestream on other sorbents. The device concentrates trace contaminants present in large volumes of breath. The charcoal cloth sorbent was evaluated for sampling and analysis of m-xylene and 1,1,1-trichloroethane under simulated physiological conditions. These samples were collected from atmospheres of either analyte generated at 35 degree -40 degree C and 80%-90% relative humidity to simulate an exhaled breath sample matrix. Concentrations sampled ranged from 2.2 to 190 mg/m super(3) for 1,1,1-trichloroethane and from 0.44 to 35.6 mg/m super(3) for m-xylene. Volumes sampled ranged from 10 to 50 L. The m-xylene samples were collected using a 3-wafer front and a 2-wafer backup bed of charcoal cloth; 1,1,1-trichloroethane samples were collected using a 10-wafer front and a 1-wafer backup bed. All samples were desorbed in carbon disulfide and analyzed via gas chromatography using a flame ionization detector. The volume of desorption solvent ranged from 1.7 to 2.5 mL per wafer of cloth.
JF  - American Industrial Hygiene Association Journal
AU  - Glaser, R A
AU  - Arnold, JE
AD  - NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 112
EP  - 121
VL  - 50
IS  - 2
SN  - 0002-8894, 0002-8894
KW  - solvents
KW  - vapor
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - steel
KW  - gas chromatography
KW  - air sampling
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15359354?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Investigation+of+charcoal+cloth+as+a+sorbent+for+integrated+sampling+of+solvent+vapors+in+mixed-expired+breath+using+a+new+stainless+steel+sampler.&rft.au=Glaser%2C+R+A%3BArnold%2C+JE&rft.aulast=Glaser&rft.aufirst=R&rft.date=1989-01-01&rft.volume=50&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - steel; air sampling; gas chromatography
ER  - 



TY  - JOUR
T1  - Reducing knee morbidity among carpetlayers.
AN  - 15340644; 2097495
AB  - Carpetlayers have a high prevalence of occupational knee morbidity, partly attributable to their use of the knee kicker to stretch carpet for wall-to-wall installation. While a mechanical alternative "power stretcher" is available, knee kickers are still widely used. A questionnaire survey indicated that unavailability of the mechanical stretcher at installation sites was a major factor for continued use of the knee kicker. Strategies to reduce use of the knee kicker are discussed.
JF  - American Journal of Public Health
AU  - Tanaka, S
AU  - Lee, ST
AU  - Halperin, W E
AU  - Thun, M
AU  - Smith, AB
AD  - MS, R-16, NIOSH, CDC, USPHS/DHHS, Robert Taft Lab., 4676 Columbia Parkw., Cincinnati, OH 45226, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 334
EP  - 335
VL  - 79
IS  - 3
SN  - 0090-0036, 0090-0036
KW  - morbidity
KW  - carpet layers
KW  - Health & Safety Science Abstracts
KW  - surveys
KW  - ergonomics
KW  - occupational health
KW  - H SI6.7:HUMAN FACTORS
KW  - H SM9.47:FOOT INJURIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15340644?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Reducing+knee+morbidity+among+carpetlayers.&rft.au=Tanaka%2C+S%3BLee%2C+ST%3BHalperin%2C+W+E%3BThun%2C+M%3BSmith%2C+AB&rft.aulast=Tanaka&rft.aufirst=S&rft.date=1989-01-01&rft.volume=79&rft.issue=3&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Special issue: Injury control.
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; surveys; ergonomics
ER  - 



TY  - JOUR
T1  - Assessment of respiratory exposures during gilsonite mining and milling operations.
AN  - 15313753; 2075148
AB  - An industrial hygiene study of the entire United States gilsonite industry was done by the National Institute for Occupational Safety and Health (NIOSH) to evaluate the potential for occupational health problems resulting from exposures to gilsonite and its constituents. Gilsonite is a solidified hydrocarbon substance mined only in northeastern Utah to Colorado. Industrial hygiene samples were collected at four gilsonite mining companies including nine mines and three mills. Gilsonite workers had no measurable exposures to polynuclear aromatic hydrocarbon (PNA) compounds, asbestos fibers, or hydrogen sulfide gas. Several organic gases/vapors and metals were detected in the airborne samples; but, none exceeded the current exposure standards/health criteria of the Mine Safety and Health Administration (MSHA), the American Conference of Governmental Industrial Hygienists (ACGIH), or NIOSH. Gilsonite workers in some job categories were exposed to high levels of dust, exceeding ACGIH nuisance dust recommendations.
JF  - American Industrial Hygiene Association Journal
AU  - Kullman, G J
AU  - Doak, C B
AU  - Keimig, D G
AU  - Cornwell, R J
AU  - Ferguson, R P
AD  - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 413
EP  - 418
VL  - 50
IS  - 8
SN  - 0002-8894, 0002-8894
KW  - hydrocarbons
KW  - vapor
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - mining
KW  - occupational health
KW  - gases
KW  - metals
KW  - air sampling
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - H SI2.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Assessment+of+respiratory+exposures+during+gilsonite+mining+and+milling+operations.&rft.au=Kullman%2C+G+J%3BDoak%2C+C+B%3BKeimig%2C+D+G%3BCornwell%2C+R+J%3BFerguson%2C+R+P&rft.aulast=Kullman&rft.aufirst=G&rft.date=1989-01-01&rft.volume=50&rft.issue=8&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; gases; metals; air sampling; mining
ER  - 



TY  - JOUR
T1  - "Worst case" aerosol testing parameters: I. Sodium chloride and dioctyl phthalate aerosol filter efficiency as a function of particle size and flow rate.
AN  - 15294129; 2045617
AB  - The efficiency of filter media is dependent on the characteristics of the challenge aerosol and the filter's construction. Challenge aerosol parameters, such as particle size, depsity, shape, electrical charge, and flow rate, are influential in determining the filter's efficiency. In this regard, a so-called "worst case" set of conditions has been proposed for testing respirator filter efficiency in order to ensure wearer protection. Data collected on various types of filters challenged with a worst case-type sodium chloride (NaCl) and dioctyl phthalate (DOP) aerosol are presented. The particle size of maximum penetration varies as a function of filter type and was < 0.25- mu m count mean diameter (CMD) in all cases.
JF  - American Industrial Hygiene Association Journal
AU  - Stevens, G A
AU  - Moyer, E S
AD  - U.S. DHHS, Public Health Serv., NIOSH, Injury Prev. Res. Branch, Lab. Invest. Sect., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 257
EP  - 264
VL  - 50
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - particle size
KW  - Pollution Abstracts
KW  - data collection
KW  - flow rates
KW  - fumes
KW  - dust
KW  - aerosols
KW  - filters
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15294129?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=%22Worst+case%22+aerosol+testing+parameters%3A+I.+Sodium+chloride+and+dioctyl+phthalate+aerosol+filter+efficiency+as+a+function+of+particle+size+and+flow+rate.&rft.au=Stevens%2C+G+A%3BMoyer%2C+E+S&rft.aulast=Stevens&rft.aufirst=G&rft.date=1989-01-01&rft.volume=50&rft.issue=5&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - flow rates; aerosols; filters; dust; fumes; data collection
ER  - 



TY  - JOUR
T1  - Residue characterization of triadimefon in grapes by gas chromatography and mass spectrometry/mass spectrometry.
AN  - 15249835; 2014165
AB  - A field study of the use of the new fungicide triadimefon (Bayleton)) on grapes has indicated that residue levels of 0.01 ppm may be expected on the ripe fruit in spite of the 60-75 day interval from spray to harvest. Triadimefon and its primary metabolite triadimenol (Baytan)) have been characterized by gas chromatography and mass spectrometry to provide identification down to a detection level of 0.001 ppm. Recovery studies on these fungicides have indicated that they are completely extracted by the single multi-residue analytical methodology presently in use for monitoring fresh procedure.
JF  - BIOMED. ENVIRON. MASS SPECTROM.
AU  - Cairns, T
AU  - Siegmund, E G
AU  - Chiu, K S
AU  - Nelson, R
AD  - DHHS, FDA, Off. Regul. Aff., Los Angeles District Lab., 1521 W. Pico Blvd., Los Angeles, CA 90015, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 110
EP  - 115
VL  - 18
IS  - 2
SN  - 0887-6134, 0887-6134
KW  - triadimefon
KW  - characterization
KW  - fruits
KW  - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts
KW  - residues
KW  - mass spectroscopy
KW  - gas chromatography
KW  - X 24120:Food, additives & contaminants
KW  - H SE5.21:FUNGICIDES
KW  - X 24222:Analytical procedures
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24136:Environmental impact
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - residues; gas chromatography; mass spectroscopy; fruits
ER  - 



TY  - JOUR
T1  - "Worst case" aerosol testing parameters: II. Efficiency dependence of commercial respirator filters on humidity pretreatment.
AN  - 15228231; 2001656
AB  - Previous studies have shown that relative humidity has a degrading effect on the performance of commercially available particulate air-purifying respirator filters. That degradation results from a reduction of charge within the filter. This study was done to evaluate the time-dependent effects of relative humidity pretreatment and the reduction of charge on filter penetration against a most penetrating, "worst case" aerosol challenge. Filters of the dust and mist; dust, fume, and mist; paint, lacquer, and enamel mist; and high efficiency types were tested after being pretreated in an environment of 38 degree C and 85% relative humidity for periods up to 42 days. After various intervals of pretreatment, the filters were tested against neutralized worst-case sodium chloride (NaCl) and dioctyl phthalate (DOP) aerosols for percent penetration. The results showed a drop in filter efficiency of approximately 2%-6% depending on preconditioning time, except for the high efficiency filters tested which showed no detectable change.
JF  - American Industrial Hygiene Association Journal
AU  - Moyer, E S
AU  - Stevens, G A
AD  - DHHS, Cent. Dis. Cont., NIOSH, Div. Saf. Res., Injury Prev. Res. Branch, Lab. Invest. Sect., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 265
EP  - 270
VL  - 50
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - aerosols
KW  - Pollution Abstracts
KW  - humidity
KW  - fumes
KW  - dust
KW  - respirators
KW  - filters
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - filters; humidity; dust; fumes; respirators
ER  - 



TY  - JOUR
T1  - Comparison of the conformation and GTP hydrolysing ability of N-terminal ras p21 protein segments.
AN  - 15200324; 1976633
AB  - Conformational, GTP binding, and GTP hydrolytic studies are carried out with synthetically prepared N-terminal 34 residue segments (residues 2-35) of p21 ras oncogene (12-Val) and non-oncogenic (12-Gly) proteins. It was found that these N-terminal regions bind nucleotides through their phosphate groups, and that substitution of valine for glycine produces a more pronounced a-helical structure and decreases the conformational flexibility. The glycine containing peptide, when compared to the valine containing analog, catalyses the hydrolysis of GTP 6 times more efficiently. Results suggest that restriction of conformational adaptation may contribute to the transforming capacity of the Val-12 p21 protein.
JF  - Biochemical and Biophysical Research Communications
AU  - Niu, Chien-Hua
AU  - Han, Kyou-Hoon
AU  - Roller, P P
AD  - Div. Metab. and Endocr. Drug Prod. (HFD-510), Cent. Drug Eval. and Res., FDA, Parklawn Build., Rockville, MD 20852, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 282
EP  - 288
VL  - 160
IS  - 1
SN  - 0006-291X, 0006-291X
KW  - N-terminus
KW  - activity
KW  - amino acid
KW  - comparison
KW  - conformation
KW  - guanine nucleotide-binding protein
KW  - protein p21
KW  - ras
KW  - ras protein
KW  - residues
KW  - structure
KW  - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts
KW  - B 26130:Ras and Ras related oncogenes (Rho/Rac/Ral)
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15200324?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Comparison+of+the+conformation+and+GTP+hydrolysing+ability+of+N-terminal+ras+p21+protein+segments.&rft.au=Niu%2C+Chien-Hua%3BHan%2C+Kyou-Hoon%3BRoller%2C+P+P&rft.aulast=Niu&rft.aufirst=Chien-Hua&rft.date=1989-01-01&rft.volume=160&rft.issue=1&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2015-03-24
N1  - SubjectsTermNotLitGenreText - N-terminus
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944364
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944364?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944335
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944335?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944132
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 7
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944132?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-01-01&rft.volume=13&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Health status of anthracite surface coal miners.
AN  - 15177127; 1954960
AB  - In 1984-1985, medical examinations consisting of a chest radiograph, spirometry test, and questionnaire on work history, respiratory symptoms, and smoking history were administered to 1061 white males who were employed at 31 coal cleaning plants and strip coal mines in the anthracite coal region of northeastern Pennsylvania. The prevalence of radiographic evidence of International Labour Office (ILO) category 1 or higher small opacities was 4.5% in 516 men who had never been employed in a dusty job other than in surface coal mining. Among these 516 workers, all 4 cases of ILO radiographic category 2 or 3 rounded opacities and 1 case of large opacities had been employed as a highwall drill operator or helper. Radiographic evidence of small rounded opacities, dyspnea, and decreases in FFV sub(1.0), FVC, and peak flow were significantly related to tenure at drilling operations after adjusting for age, height, cigarette smoking status, and exposures in dusty jobs other than in surface coal mining.
JF  - Archives of Environmental Health
AU  - Amandus, HE
AU  - Petersen, M R
AU  - Richards, T B
AD  - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 75
EP  - 81
VL  - 44
IS  - 2
SN  - 0003-9896, 0003-9896
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - mining
KW  - respiratory system
KW  - occupational health
KW  - cigarettes
KW  - coal
KW  - H SM9.31:INHALATION INJURIES
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SI2.20:COAL INDUSTRIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15177127?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Health&rft.atitle=Health+status+of+anthracite+surface+coal+miners.&rft.au=Amandus%2C+HE%3BPetersen%2C+M+R%3BRichards%2C+T+B&rft.aulast=Amandus&rft.aufirst=HE&rft.date=1989-01-01&rft.volume=44&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Health&rft.issn=00039896&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - coal; mining; occupational health; cigarettes; respiratory system
ER  - 



TY  - JOUR
T1  - Hearing-Impaired Alcoholics - An Underserved Community
AN  - 1474334665
JF  - Alcohol Health and Research World
AU  - Kearns, Gladys A
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 162
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334665?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Hearing-Impaired+Alcoholics+-+An+Underserved+Community&rft.au=Kearns%2C+Gladys+A&rft.aulast=Kearns&rft.aufirst=Gladys&rft.date=1989-01-01&rft.volume=13&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Part 2: Biochemical Studies
AN  - 1474334601
JF  - Alcohol Health and Research World
AU  - Hoffman, Paula L
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 352
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334601?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - How Extensive Is the Problem of Alcoholism?
AN  - 1474334585
JF  - Alcohol Health and Research World
AU  - Ashley, Mary Jane
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 305
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334585?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Absorption+and+Utilization+of+Nutrients+in+Alcoholism&rft.au=Feinman%2C+Lawrence&rft.aulast=Feinman&rft.aufirst=Lawrence&rft.date=1989-01-01&rft.volume=13&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Nutrition: An Overview
AN  - 1474334579
JF  - Alcohol Health and Research World
AU  - Lieber, Charles S
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 197
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - How Alcohol Damages the Body
AN  - 1474334532
JF  - Alcohol Health and Research World
AU  - Rubin, Emanuel
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 322
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474334532?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=How+Alcohol+Damages+the+Body&rft.au=Rubin%2C+Emanuel&rft.aulast=Rubin&rft.aufirst=Emanuel&rft.date=1989-01-01&rft.volume=13&rft.issue=4&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcoholism and Pancreatitis: Does Nutrition Play a Role?
AN  - 1474334475
JF  - Alcohol Health and Research World
AU  - Korsten, Mark A
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 232
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 21: Alcohol-Related Morbidity Among the Disabled: The Medicare Experience 1985
AN  - 1474334438
JF  - Alcohol Health and Research World
AU  - Dufour, Mary C
AU  - Bertolucci, Darryl
AU  - Cowell, Carol
AU  - Stinson, Frederick S
AU  - Noble, John
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 158
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Alcoholism and Scientific Progress: Recognizing the Discovery Curve
AN  - 1474334428
JF  - Alcohol Health and Research World
AU  - Gordis, Enoch
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 298
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - How Can Alcoholism Treatment Be Improved?
AN  - 1474334407
JF  - Alcohol Health and Research World
AU  - Gallant, Donald M
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 328
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - A New Agenda for Alcohol Research: The Institute of Medicine Reports on Causes and Consequences - A Summary
AN  - 1474334341
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 183
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol and Vitamin A
AN  - 1474334316
JF  - Alcohol Health and Research World
AU  - Leo, Maria Anna
AU  - Lieber, Charles S
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 250
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Principles of Clinical Education
AN  - 1474330264
JF  - Alcohol Health and Research World
AU  - McGaghie, William C
AU  - Stritter, Frank T
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - The Evaluation of Change in Medical Education on Alcohol Issues
AN  - 1474329231
JF  - Alcohol Health and Research World
AU  - Stokes, Emma
AU  - Adger, Hoover
AU  - Levine, David
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 32
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - A Training Model for Student Research in Alcohol and Other Drug Problems
AN  - 1474327807
JF  - Alcohol Health and Research World
AU  - Schnoll, Sidney H
AU  - Horvatich, Paula K
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 20
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Medical Education Still Needs Attention - Margaret Bean-Bayog Speaks Out
AN  - 1474326476
JF  - Alcohol Health and Research World
AU  - Bean-Bayog, Margaret
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 14
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Putting Training About Alcohol and Other Drugs into the Mainstream of Medical Education
AN  - 1474325608
JF  - Alcohol Health and Research World
AU  - Lewis, David C
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 8
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Residents Learn in a Hospital Setting
AN  - 1474324554
JF  - Alcohol Health and Research World
AU  - Lerner, William D
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 40
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol-Induced Liver Disease: Does Nutrition Play a Role?
AN  - 1474322037
JF  - Alcohol Health and Research World
AU  - Rothschild, Marcus A
AU  - Oratz, Murray
AU  - Schreiber, Sidney S
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 229
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Why Are Some People More Susceptible to Alcoholism?
AN  - 1474321927
JF  - Alcohol Health and Research World
AU  - Li, Ting-Kai
AU  - LOCKMULLER, JANE C
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 310
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Intramural Research at NIAAA
AN  - 1474321923
JF  - Alcohol Health and Research World
AU  - Tabakoff, Boris
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 344
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Part 1: Electrophysiological Studies
AN  - 1474321868
JF  - Alcohol Health and Research World
AU  - Weight, Forrest F
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 352
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Opportunities in Alcohol Research
AN  - 1474321829
JF  - Alcohol Health and Research World
AU  - Chao, Helen M
AU  - Shafer, W Sue
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 358
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Population Projections Using DSM - III Criteria: Alcohol Abuse and Dependence, 1990-2000
AN  - 1474321777
JF  - Alcohol Health and Research World
AU  - Williams, Gerald D
AU  - Grant, Bridget F
AU  - Harford, Thomas C
AU  - Noble, John
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 366
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - NIAAA and Alcohol Research: A Researcher's View
AN  - 1474321738
JF  - Alcohol Health and Research World
AU  - Lieber, Charles S
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 301
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Epidemiologic Bulletin No. 22: Diet and Alcohol Consumption in the General Population: Preliminary Findings
AN  - 1474321715
JF  - Alcohol Health and Research World
AU  - Brooks, Sharon
AU  - Williams, Gerald
AU  - Stinson, Frederick
AU  - Dufour, Mary C
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 272
CY  - Rockville
PB  - <span class="hit">Public</span> <span class="hit">Health</span> <span class="hit">Service</span>, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Intervention with Visually Impaired Children of Alcoholics
AN  - 1474321648
JF  - Alcohol Health and Research World
AU  - Saulnier, Christine
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 132
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Pathogenesis of Fetal Alcohol Syndrome: Overview with Emphasis on the Possible Role of Nutrition
AN  - 1474321587
JF  - Alcohol Health and Research World
AU  - Phillips, Deborah K
AU  - Henderson, George I
AU  - Schenker, Steven
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 219
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Special Populations: NIAAA's Homeless Initiative: An Update
AN  - 1474321582
JF  - Alcohol Health and Research World
AU  - LUBRAN, BARBARA G
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 281
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Preventing B Vitamin Deficiencies in Alcoholics
AN  - 1474321449
JF  - Alcohol Health and Research World
AU  - Roe, Daphne A
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 247
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - From the Editors
AN  - 1474321426
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 195
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - From Clinical Research to Secondary Prevention: International Collaboration in the Development of the Alcohol Use Disorders Identification Test (AUDIT)
AN  - 1474321422
JF  - Alcohol Health and Research World
AU  - Babor, Thomas F
AU  - Grant, Marcus
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 371
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - California Responds: Changing Treatment Systems Through Advocacy for the Disabled
AN  - 1474321411
JF  - Alcohol Health and Research World
AU  - Miranda, John De
AU  - Cherry, Linda
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 154
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Eating Disorders and Alcohol and Other Drug Abuse: Is There an Association?
AN  - 1474321383
JF  - Alcohol Health and Research World
AU  - Jonas, Jeffrey M
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 267
CY  - Rockville
PB  - <span class="hit">Public</span> <span class="hit">Health</span> <span class="hit">Service</span>, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Highlights from the 1987 National Drug and Alcoholism Treatment Unit Survey (NDATUS)
AN  - 1474321376
JF  - Alcohol Health and Research World
AU  - Harris, Joan R
AU  - Colliver, James D
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 178
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - From the Editors
AN  - 1474321325
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 291
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Absorption and Utilization of Nutrients in Alcoholism
AN  - 1474321311
JF  - Alcohol Health and Research World
AU  - Feinman, Lawrence
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 207
CY  - Rockville
PB  - <span class="hit">Public</span> <span class="hit">Health</span> <span class="hit">Service</span>, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Occupational Arena: Treating Patients with Alcohol-Related Trauma - A Report from the ARUS Symposium
AN  - 1474321226
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 168
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Alcoholism and Bullous Changes of the Lungs
AN  - 1474321213
JF  - Alcohol Health and Research World
AU  - Cramer, Sidney L
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 166
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - What Characterizes Addiction?
AN  - 1474321190
JF  - Alcohol Health and Research World
AU  - Meyer, Roger E
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 316
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - International Perspectives: Alcohol-Related Trauma in Mexico
AN  - 1474321175
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 174
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol, Fatty Acids, and Diet
AN  - 1474321123
JF  - Alcohol Health and Research World
AU  - Salem, Norman
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 211
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Biological Research at NIAAA
AN  - 1474321106
JF  - Alcohol Health and Research World
AU  - Kunos, George
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 351
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol and Other Drug Abuse by the Physically Impaired: A Challenge for Rehabilitation Educators
AN  - 1474317815
JF  - Alcohol Health and Research World
AU  - Greer, Bobby G
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 144
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol Abuse and Persons Who Are Blind: Treatment Considerations
AN  - 1474317789
JF  - Alcohol Health and Research World
AU  - NELIPOVICH, MICHAEL
AU  - Buss, Elmer
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 128
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Introduction
AN  - 1474317785
JF  - Alcohol Health and Research World
AU  - Goodwin, Frederick K
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 293
CY  - Rockville
PB  - <span class="hit">Public</span> <span class="hit">Health</span> <span class="hit">Service</span>, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Prevention of Alcohol-Related Problems
AN  - 1474317737
JF  - Alcohol Health and Research World
AU  - Holder, Harold D
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 339
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Special Populations: NIAAA Support for Studies on Hispanic-Americans
AN  - 1474317727
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 176
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Results of a Model Intervention Program for Physically Impaired Persons
AN  - 1474317666
JF  - Alcohol Health and Research World
AU  - SCHASCHL, SHARON
AU  - Straw, Dennis
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 150
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Effects of Alcohol on Electrolytes and Minerals
AN  - 1474317658
JF  - Alcohol Health and Research World
AU  - Marsano, Luis
AU  - McClain, Craig J
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 255
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Epilepsy, Seizures, and Alcohol
AN  - 1474317622
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL J
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 138
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Nutritional Advice and Diet Instruction in Alcoholism Treatment
AN  - 1474317395
JF  - Alcohol Health and Research World
AU  - HAUSER, MARION BOOMER
AU  - Iber, Frank Lynn
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 261
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Effects of Ethanol on Carbohydrate Metabolism and Implications for the Aging Alcoholic
AN  - 1474317308
JF  - Alcohol Health and Research World
AU  - Patel, D G
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 240
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol Problem Intervention in the Workplace: Data on Present Status and Future Implications
AN  - 1474317267
JF  - Alcohol Health and Research World
AU  - Roman, Paul M
AU  - Blum, Terry C
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 375
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Research Report: Measuring Alcohol Intake Using Dietary Survey Data
AN  - 1474317199
JF  - Alcohol Health and Research World
AU  - Flegal, Katherine M
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 277
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Alcohol Withdrawal Syndrome and Sympathetic Nervous System Function
AN  - 1474317122
JF  - Alcohol Health and Research World
AU  - Linnoila, Markku
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 355
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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TY  - JOUR
T1  - Highlights of the Surgeon General's Report on Nutrition and Health
AN  - 1474317103
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 285
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - ETOH: The NIAAA Data Base - What It Is and What To Expect From It
AN  - 1474303115
JF  - Alcohol Health and Research World
AU  - McGinn, Ellen T
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 24
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Literature: a Key Resource for Students and Faculty
AN  - 1474302905
JF  - Alcohol Health and Research World
AU  - O' Brien, Charles P
AU  - Woody, George E
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 16
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - American Medical Students Association: Medical Students Concerned with Alcohol and Other Drug Abuse
AN  - 1474302542
JF  - Alcohol Health and Research World
AU  - Hedgecock, Joan
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 77
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Facing the Challenge
AN  - 1474302398
JF  - Alcohol Health and Research World
AU  - Boros, Alexander
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 101
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - International Perspectives: "Alcohol-Related Topics in Medical Education - Activities at the Karolinska Institute"
AN  - 1474302394
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL J
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 88
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Targets for Change in Alcohol and Drug Education for Nursing Roles
AN  - 1474302376
JF  - Alcohol Health and Research World
AU  - Naegle, Madeline A
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 52
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The J.M. Foundation: Mainstreaming Alcohol and Drug Issues in American Medicine
AN  - 1474302370
JF  - Alcohol Health and Research World
AU  - Dolan, Joseph S
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 74
CY  - Rockville
PB  - <span class="hit">Public</span> <span class="hit">Health</span> <span class="hit">Service</span>, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Certification and the Specialty for Addictions Nursing
AN  - 1474302368
JF  - Alcohol Health and Research World
AU  - Solari-Twadell, Ann
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 57
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 20: Alcohol-Related Morbidity in the Aging Population
AN  - 1474302367
JF  - Alcohol Health and Research World
AU  - Stinson, Frederick S
AU  - Dufour, Mary C
AU  - Bertolucci, Darryl
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 80
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - The Pew Charitable Trusts
AN  - 1474302357
JF  - Alcohol Health and Research World
AU  - SHMAVONIAN, NADYA K
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 75
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Pacific Institute for Research and Evaluation: Health Professionals as Preventors
AN  - 1474302353
JF  - Alcohol Health and Research World
AU  - Klitzner, Michael D
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 76
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Alcohol Abuse and Traumatic Brain Injury
AN  - 1474302351
JF  - Alcohol Health and Research World
AU  - Jones, Gregory A
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 104
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Readers' Exchange: "Disulfiram Administration Should Be Noncoercive - Even for Research"
AN  - 1474302235
JF  - Alcohol Health and Research World
AU  - McNichol, Ronald W
AU  - Logsdon, Steven A
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 93
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Nurse Educators Look at Alcohol Education for the Profession
AN  - 1474302213
JF  - Alcohol Health and Research World
AU  - Heinemann, M Edith
AU  - Hoffman, Agnes L
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports: "Alcohol and Injury: Surgical Knowledge and Attitudes"
AN  - 1474302205
JF  - Alcohol Health and Research World
AU  - Lowenfels, Albert B
AU  - Soderstrom, Carl A
AU  - ZUSKA, JOSEPH J
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 91
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Double Trouble: Alcohol and Other Drug Use Among Orthopedically Impaired College Students
AN  - 1474302197
JF  - Alcohol Health and Research World
AU  - Moore, Dennis
AU  - Siegal, Harvey
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 118
CY  - Rockville
PB  - <span class="hit">Public</span> <span class="hit">Health</span> <span class="hit">Service</span>, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Treatment of Alcohol Abuse in Persons with Recent Spinal Cord Injuries
AN  - 1474302192
JF  - Alcohol Health and Research World
AU  - Heinemann, Allen W
AU  - Doll, Matthew
AU  - Schnoll, Sidney
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 110
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - BHCDA: A Federal Model for Collaboration
AN  - 1474302189
JF  - Alcohol Health and Research World
AU  - Chen, Vivian
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 64
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - From the Editors
AN  - 1474302188
JF  - Alcohol Health and Research World
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 99
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Project Cork Institute
AN  - 1474302187
JF  - Alcohol Health and Research World
AU  - Kinney, Jean
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 72
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Occupational Arena: "Health Professionals Work on Improving Curriculums"
AN  - 1474302186
JF  - Alcohol Health and Research World
AU  - Portugal, Frank
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 89
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Special Populations: "Services for Native Americans"
AN  - 1474302185
JF  - Alcohol Health and Research World
AU  - Smith, Eva Marie
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 94
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Stopping Silent Losses: The American Medical Association Responds
AN  - 1474302184
JF  - Alcohol Health and Research World
AU  - Wilford, Bonnie B
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 69
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Family Medicine Fellowship Training Program for Alcohol and Drug Abuse Faculty
AN  - 1474302182
JF  - Alcohol Health and Research World
AU  - Coggan, Peter
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 60
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Experience is the Key to Certification for Chemical Dependency Nurses
AN  - 1474302173
JF  - Alcohol Health and Research World
AU  - Bryson, Randy
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 58
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Arthritic Disease and Alcohol Abuse
AN  - 1474302170
JF  - Alcohol Health and Research World
AU  - Nashel, David J
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 124
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Association for Medical Education and Research in Substance Abuse (AMERSA)
AN  - 1474302168
JF  - Alcohol Health and Research World
AU  - Lewis, David C
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 68
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Learning Through Experience: Interviewing Real(?) Patients
AN  - 1474301891
JF  - Alcohol Health and Research World
AU  - Spickard, Anderson
AU  - Johnson, N Peter
AU  - Burger, Candice
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 36
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Foreword
AN  - 1474301570
JF  - Alcohol Health and Research World
AU  - Cotter, Frances
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Drug Abuse as a Subspecialty: Credentialing and Specialization
AN  - 1474300936
JF  - Alcohol Health and Research World
AU  - Galanter, Marc
Y1  - 1989/01/01/
PY  - 1989
DA  - 1989 Jan 01
SP  - 42
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 13
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - AIDS -- Tribal Nations Face the Newest Communicable Disease: An Aberdeen Area Perspective
AN  - 1463018750; 91X3189
AB  - In earlier centuries, smallpox, cholera, tuberculosis, & other diseases brought to America by Europeans were major factors in decimating the Native American population. The acquired immune deficiency syndrome (AIDS) epidemic has similar potential, even though the current rate of AIDS cases among Native Americans is less than in other minority populations. However, risk of contracting AIDS among Native Americans is increased by various factors, including inadequate medical resources & social behaviors such as alcoholism. The causes, symptoms, & transmission processes of AIDS are described, & the status of AIDS & preventative programs within the Aberdeen area (ND, SD, Neb, & Iowa) Native American community is reviewed. Cooperation between tribal governments & public health agencies in the matter of health education in the Indian communities is deemed imperative, especially where certain skin-piercing rituals are still practiced. M. Pflum
JF  - American Indian Culture and Research Journal
AU  - Claymore, Betty J
AU  - Taylor, Marian A
AD  - Nashville Area Office Indian Health Service, TN 37204
Y1  - 1989///0,
PY  - 1989
DA  - 0, 1989
SP  - 21
EP  - 31
VL  - 13
IS  - 3-4
SN  - 0161-6463, 0161-6463
KW  - acquired immune deficiency syndrome epidemic/prevention programs, Native American population, US
KW  - Prevention
KW  - Epidemics
KW  - Acquired Immune Deficiency Syndrome
KW  - Health Behavior
KW  - United States of America
KW  - American Indians
KW  - article
KW  - 2045: sociology of health and medicine; sociology of medicine (public health)
KW  - 0410: group interactions; interaction between (large) groups (race relations, ethnicity, & inter-ethnic relations)
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LA  - English
DB  - Sociological Abstracts
N1  - Date revised - 2013-12-01
N1  - Last updated - 2016-09-28
N1  - CODEN - AICJEV
N1  - SubjectsTermNotLitGenreText - United States of America; American Indians; Acquired Immune Deficiency Syndrome; Epidemics; Prevention; Health Behavior
ER  - 



TY  - JOUR
T1  - Polycyclic aromatic hydrocarbon degradation by a Mycobacterium sp. in microcosms containing sediment and water from a pristine ecosystem
AN  - 13754881; 199000442
AB  - A Mycobacterium previously isolated from a eutrophic estuarine ecosystem was tested for its ability to degrade various PAH compounds in a simulated environment. Microcosms inoculated with the selected strains showed an enhanced rate of mineralization for pyrene, 2-methylnaphthalene, phenanthrene and benzo-(a)-pyrene. Multiple doses of pyrene were mineralized during periods of up to six weeks; competition with other micro-organisms did not adversely affected survival of pyrene degrading ability of the organism, but pyrene mineralization was impeded by enrichment with organic nutrients, probably due to overgrowth of the indigenous bacteria. The selected strain was apparently capable of degrading PAH compounds having a two-, three-, four- or five-ringed structure under the conditions prevailing in sediments of river or estuarine origin.
JF  - Applied and Environmental Microbiology
AU  - Heitkamp, MA
AU  - Cerniglia, CE
AD  - Food and Drug Administration, Jefferson, Ark.
Y1  - 1989
PY  - 1989
DA  - 1989
SP  - 1968
EP  - 1973
VL  - 55
IS  - 8
SN  - 0099-2240, 0099-2240
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Oxidative detection of coulometrically reduced organonitro pesticides in reversed-phase high-performance liquid chromatography.
AN  - 78750249; 3243894
AB  - A high-performance liquid chromatographic system is presented for determination of organonitro pesticides, metabolites and industrial chemicals having a variety of chemical structures. The compounds are chromatographed on a C8 column with an acetonitrile-aqueous ammonium monochloroacetate gradient. The chromatographic responses of the compounds are monitored indirectly by oxidative detection of the coulometrically reduced organonitro functionality by means of a porousgraphite detector. Three nitrophenols (2,4-dinitrophenol, 4,6-dinitro-o-cresol and dinoseb), a dinitrophenyl aliphatic ester (binapacryl) and a nitroaniline (dicloran) were detected at low nanogram levels (3-10 ng for 50% recorder full-scale deflection). This technique overcomes the problems of high background currents and oxygen interference, observed in the direct reductive detection of organonitro compounds.
JF  - Journal of chromatography
AU  - Krause, R T
AU  - Wang, Y
AD  - Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/12/28/
PY  - 1988
DA  - 1988 Dec 28
SP  - 151
EP  - 162
VL  - 459
KW  - Nitro Compounds
KW  - 0
KW  - Pesticides
KW  - Index Medicus
KW  - Oxidation-Reduction
KW  - Electrochemistry
KW  - Chromatography, High Pressure Liquid
KW  - Pesticides -- analysis
KW  - Nitro Compounds -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-06-06
N1  - Date created - 1989-06-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Liquid chromatographic resolution of hypoglycin A from leucine.
AN  - 78746242; 3243880
JF  - Journal of chromatography
AU  - Chase, G W
AU  - Landen, W O
AU  - Soliman, A M
AD  - Food and Drug Administration, Atlanta, GA 30309.
Y1  - 1988/12/16/
PY  - 1988
DA  - 1988 Dec 16
SP  - 431
EP  - 434
VL  - 456
IS  - 2
KW  - Amino Acids
KW  - 0
KW  - Buffers
KW  - Cyclopropanes
KW  - Hypoglycins
KW  - Indicators and Reagents
KW  - hypoglycin
KW  - 156-56-9
KW  - Leucine
KW  - GMW67QNF9C
KW  - Index Medicus
KW  - Amino Acids -- isolation & purification
KW  - Chromatography, Liquid
KW  - Chromatography, Ion Exchange
KW  - Cyclopropanes -- isolation & purification
KW  - Leucine -- isolation & purification
KW  - Hypoglycins -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-06-02
N1  - Date created - 1989-06-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Research activities in toxicology and toxicological requirements of the FDA for food and color additives.
AN  - 78786427; 3077268
AB  - The Center for Food Safety and Applied Nutrition of the Food and Drug Administration has published guidelines for the safety assessment of direct food and color additives. These guidelines are to be updated beginning in 1988. The safety of a food and color additive must be established prior to marketing by an evaluation of probable exposure of consumers and appropriate toxicological information. "Safe" and "safety" are defined as a reasonable certainty that a substance is not harmful under the intended conditions of use. A number of tests are used in determining the safety of food additives. Some of these are: subchronic toxicity studies, chronic toxicity studies, carcinogenicity, reproduction, teratogenicity, and occasionally short-term tests for carcinogenicity. The Center also has a research program in toxicology which in part focuses on diet/toxicity interaction and risk assessment. Examples of such activities are investigation of the teratogenicity of textured vegetable protein and of the potential of zinc to prevent or ameliorate such effects, the development of whole rat embryo cultures as a model to investigate the mechanisms by which teratogens may act, and a program in pharmacokinetics and molecular toxicology to aid in studying assumptions underlying risk assessment.
JF  - Biomedical and environmental sciences : BES
AU  - Green, S
AD  - Division of Toxicology, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 424
EP  - 430
VL  - 1
IS  - 4
SN  - 0895-3988, 0895-3988
KW  - Food Additives
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - Research
KW  - United States Food and Drug Administration
KW  - Toxicology -- methods
KW  - Food Additives -- toxicity
KW  - Food Additives -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-12-12
N1  - Date created - 1989-12-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Comments on Allen et al. Correlation between carcinogenic potency of chemicals in animals and humans.
AN  - 78734386; 3244860
JF  - Risk analysis : an official publication of the Society for Risk Analysis
AU  - Hart, R
AU  - Turturro, A
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 545
EP  - 547
VL  - 8
IS  - 4
SN  - 0272-4332, 0272-4332
KW  - Carcinogens
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Risk Factors
KW  - Humans
KW  - Carcinogenicity Tests
KW  - Data Interpretation, Statistical
KW  - Predictive Value of Tests
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-06-01
N1  - Date created - 1989-06-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Synthetic oligodeoxyribonucleotide probes for detection of Listeria monocytogenes.
AN  - 78669265; 3146945
AB  - A 500-base-pair DNA fragment of a presumptive beta-hemolysin gene of Listeria monocytogenes has been used to identify this organism by a modified colony hybridization technique. We have cloned this DNA fragment into M13 bacteriophage vectors and sequenced it by a dideoxynucleotide sequencing technique. From this sequencing information, several oligodeoxyribonucleotides were synthesized and used as synthetic probes to identify L. monocytogenes. The probes were specific for L. monocytogenes and did not react with any other Listeria strains in a colony hybridization assay. In particular, one of these probes (AD07) was used to detect L. monocytogenes in artificially contaminated raw-milk and soft-cheese samples.
JF  - Applied and environmental microbiology
AU  - Datta, A R
AU  - Wentz, B A
AU  - Shook, D
AU  - Trucksess, M W
AD  - Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 2933
EP  - 2937
VL  - 54
IS  - 12
SN  - 0099-2240, 0099-2240
KW  - DNA Probes
KW  - 0
KW  - DNA, Bacterial
KW  - Hemolysin Proteins
KW  - Index Medicus
KW  - Genes, Bacterial
KW  - Base Sequence
KW  - Food Microbiology
KW  - DNA, Bacterial -- isolation & purification
KW  - DNA, Bacterial -- genetics
KW  - Hemolysin Proteins -- genetics
KW  - Food Contamination
KW  - Nucleic Acid Hybridization
KW  - Listeria monocytogenes -- isolation & purification
KW  - Listeria monocytogenes -- genetics
KW  - DNA Probes -- chemical synthesis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-16
N1  - Date created - 1989-03-16
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Bacteriol Rev. 1966 Jun;30(2):309-82 [4956900]
Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 [5963888]
Proc Natl Acad Sci U S A. 1975 Oct;72(10):3961-5 [1105573]
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968]
N Engl J Med. 1983 Jan 27;308(4):203-6 [6401354]
Plasmid. 1983 Nov;10(3):296-8 [6657780]
N Engl J Med. 1985 Feb 14;312(7):404-7 [3918263]
Infect Immun. 1986 Jan;51(1):314-9 [3079734]
Arch Intern Med. 1986 Mar;146(3):520-4 [3954524]
Infect Immun. 1986 Apr;52(1):50-5 [3007363]
Appl Environ Microbiol. 1986 Nov;52(5):1215-7 [3024563]
J Bacteriol. 1987 Mar;169(3):1291-7 [3029033]
Appl Environ Microbiol. 1987 Sep;53(9):2256-9 [2823710]
Lancet. 1988 Jan 23;1(8578):177-8 [2893009]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Monitoring adverse reactions to food additives in the U.S. Food and Drug Administration.
AN  - 78658390; 3222485
AB  - Technological advances in food science have resulted in the development of numerous food additives, most of which require premarket approval by the Food and Drug Administration (FDA). Concomitant with the benefits of these additives, such as extending the shelf life of certain food commodities, is the potential for various risks. These potential risks include the possibility of the consumer experiencing an adverse reaction to the additive. In order to ascertain the character and the gravity of alleged adverse reactions to food products which it regulates, the FDA's Center for Food Safety and Applied Nutrition has developed the Adverse Reaction Monitoring System (ARMS). This postmarketing surveillance system for food additives is designed to analyze consumer reports of adverse reactions in order to alert FDA officials about any potential public health hazard associated with an approved food additive, and to delineate specific syndromes which may lead to focused clinical investigations. To date, among the products routinely monitored in the ARMS, sulfiting agents and the artificial sweetener aspartame have generated the largest volume of consumer reports describing adverse reactions. An overview of the analyses of the sulfite and aspartame adverse reaction reports is presented, along with a description of the mechanics of the postmarketing surveillance system, and a detailed discussion of its limitations.
JF  - Regulatory toxicology and pharmacology : RTP
AU  - Tollefson, L
AD  - Office of Nutrition and Food Sciences, U.S. Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 438
EP  - 446
VL  - 8
IS  - 4
SN  - 0273-2300, 0273-2300
KW  - Food Additives
KW  - 0
KW  - Sulfites
KW  - Aspartame
KW  - Z0H242BBR1
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Aspartame -- adverse effects
KW  - Sulfites -- adverse effects
KW  - United States Food and Drug Administration
KW  - Product Surveillance, Postmarketing -- methods
KW  - Food Additives -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-17
N1  - Date created - 1989-03-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Estimates of the risk of bladder tumor promotion by saccharin in rats.
AN  - 78648944; 3222487
AB  - Tumor data from an initiation-promotion bioassay in rats are used to illustrate how urinary bladder tumor risk estimates can be modified to reflect tumor promotion by saccharin. Assuming equal carcinogenic potency in humans and rats, the estimated human risk is equal to the probability of tumors in rats due to saccharin promotion following administration of an initiator times the ratio of the proportion of humans that are initiated to the proportion of initiated rats. The proportion of initiated humans may be somewhere between the proportion of deaths due to bladder cancer in the U.S. population, 0.005, and 1.0. The proportion of initiated animals in the bioassay may be somewhere between the proportion of animals with bladder tumors, 0.41, as observed in an initiated group, and 1.0. Hence, the ratio of the proportion of initiated humans to animals may be between 0.005 and 2.4. Then, the risk of bladder tumors is estimated to be between 0.005 and 2.4 times the estimated risk of tumors in rats promoted by saccharin following administration of an initiator. An upper limit on bladder tumor risk is estimated to be between 0.00038 and 0.18 times the percentage of saccharin in the diet. If a threshold dose exists for saccharin bladder tumor promotion which is above the saccharin consumption level of all humans, then the risk is zero.
JF  - Regulatory toxicology and pharmacology : RTP
AU  - Gaylor, D W
AU  - Kadlubar, F F
AU  - West, R W
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 467
EP  - 470
VL  - 8
IS  - 4
SN  - 0273-2300, 0273-2300
KW  - Saccharin
KW  - FST467XS7D
KW  - Index Medicus
KW  - United States
KW  - Rats
KW  - Animals
KW  - Risk Factors
KW  - Saccharin -- toxicity
KW  - Urinary Bladder Neoplasms -- mortality
KW  - Urinary Bladder Neoplasms -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-17
N1  - Date created - 1989-03-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Occupational dermatoses.
AN  - 78584373; 2974462
JF  - Journal of the American Academy of Dermatology
AU  - Mathias, C G
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 1107
EP  - 1114
VL  - 19
IS  - 6
SN  - 0190-9622, 0190-9622
KW  - Index Medicus
KW  - Photosensitivity Disorders -- etiology
KW  - Connective Tissue Diseases -- etiology
KW  - Humans
KW  - Skin Neoplasms -- etiology
KW  - Workers' Compensation
KW  - Vitiligo -- chemically induced
KW  - Urticaria -- etiology
KW  - Acne Vulgaris -- chemically induced
KW  - Dermatitis, Contact -- etiology
KW  - Acne Vulgaris -- diagnosis
KW  - Connective Tissue Diseases -- diagnosis
KW  - Urticaria -- diagnosis
KW  - Vitiligo -- diagnosis
KW  - Protective Clothing
KW  - Photosensitivity Disorders -- diagnosis
KW  - Dermatitis, Contact -- diagnosis
KW  - Dermatitis, Occupational -- etiology
KW  - Dermatitis, Occupational -- prevention & control
KW  - Bibliography as Topic
KW  - Dermatitis, Occupational -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-27
N1  - Date created - 1989-01-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Heart disease mortality among bridge and tunnel officers exposed to carbon monoxide.
AN  - 78552906; 2461656
AB  - The authors investigated the effect of occupational exposure to carbon monoxide on mortality from heart disease in a retrospective study of 5,529 New York City bridge and tunnel officers employed between January 1, 1952 and February 10, 1981, at any one of nine major water crossings operated by the Triborough Bridge and Tunnel Authority of New York City. Among former tunnel officers, 61 deaths from arteriosclerotic heart disease were observed, as compared with 45 expected (standardized mortality ratio = 1.35, 90% confidence interval 1.09-1.68); expected rates were based on the New York City population. Using a proportional hazards model, the authors compared the risk of mortality from arteriosclerotic heart disease among tunnel officers with that of the less-exposed bridge officers. No association of arteriosclerotic heart disease with length of exposure was observed, but there was significant interaction of exposure with age. The elevated risk of arteriosclerotic heart disease among tunnel officers, as compared with that of bridge officers, declined after cessation of exposure, with much of the risk dissipating within as little as five years. The parallel findings of this study of occupational exposure to carbon monoxide and those studies showing the relation of cigarette smoking to cardiovascular mortality suggest that carbon monoxide may play an important role in the pathophysiology of cardiovascular mortality associated with cigarette smoking.
JF  - American journal of epidemiology
AU  - Stern, F B
AU  - Halperin, W E
AU  - Hornung, R W
AU  - Ringenburg, V L
AU  - McCammon, C S
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 1276
EP  - 1288
VL  - 128
IS  - 6
SN  - 0002-9262, 0002-9262
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Vehicle Emissions
KW  - Index Medicus
KW  - New York City
KW  - Coronary Artery Disease -- etiology
KW  - Epidemiologic Methods
KW  - Humans
KW  - Death Certificates
KW  - Adult
KW  - Coronary Artery Disease -- epidemiology
KW  - Aged
KW  - Middle Aged
KW  - Male
KW  - Coronary Artery Disease -- mortality
KW  - Heart Diseases -- epidemiology
KW  - Air Pollutants, Occupational -- adverse effects
KW  - Occupational Diseases -- etiology
KW  - Heart Diseases -- mortality
KW  - Occupational Diseases -- epidemiology
KW  - Carbon Monoxide Poisoning -- complications
KW  - Heart Diseases -- etiology
KW  - Vehicle Emissions -- adverse effects
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-05
N1  - Date created - 1989-01-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - HIV infection: risks to health care workers and infection control.
AN  - 78550018; 3057464
AB  - The risk for occupational transmission of HIV-1 in the health setting is extremely small. Current data from a number of prospective studies of health care workers sustaining adverse exposure to blood or other body fluids from patients infected with HIV-1 demonstrate that the rate for transmission of infection following a needlestick injury is approximately 0.5%. Similar data regarding the risk for occupational transmission of hepatitis B virus infection, however, indicates that the rate of transmission of infection with this virus following a needlestick injury may be as high as 30% and the risk for transmission of other blood-borne infections is poorly defined. Infection control precautions designed to minimize the risk for HIV-1 infection were recommended by CDC shortly following the first reported case of AIDS in the United States. These measures were implemented for patients diagnosed with or suspected to be infected with HIV-1, determined by history-taking or serologic evaluation. The inability of these mechanisms to accurately identify all infected individuals, coupled with the occurrence of undiagnosed or unrecognized blood-borne infections, emphasizes the need for health care workers to consider all patients as potentially infected with HIV-1 or other blood-borne pathogens. Implementation and enforcement of universal precautions should minimize exposure of health care personnel to blood and body fluids and thus substantially reduce the risk for occupational transmission of HIV-1 and other blood-borne infections in the health care environment.
JF  - The Nursing clinics of North America
AU  - Henderson, D J
AD  - United States Food and Drug Administration, Bethesda, Maryland.
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 767
EP  - 777
VL  - 23
IS  - 4
SN  - 0029-6465, 0029-6465
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Nursing
KW  - AIDS/HIV
KW  - Humans
KW  - Acquired Immunodeficiency Syndrome -- prevention & control
KW  - Occupational Diseases -- transmission
KW  - Occupational Diseases -- prevention & control
KW  - Acquired Immunodeficiency Syndrome -- transmission
KW  - Health Occupations
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-28
N1  - Date created - 1988-12-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Effect of pretreatment with ICRF-187 on the total cumulative dose of doxorubicin tolerated by beagle dogs.
AN  - 78491360; 3141049
AB  - Studies were made of the influence of ICRF-187 on the functional and morphological effects of very large cumulative doses of doxorubicin given over a prolonged period of time. Adult beagles of either sex (6.2-11.6 kg) were given doxorubicin (1.75 mg/kg i.v.) either alone or 15 min after ICRF-187 (25 mg/kg, i.v.) at 3-week intervals. Control dogs received ICRF-187 (25 mg/kg, i.v.) or 0.9% saline without doxorubicin. Of eight animals receiving doxorubicin alone, five died; two after a total dose of 12.25 mg/kg and three after 14 mg/kg; three others were in poor condition at the time of euthanasia after 14 mg/kg. Of eight animals receiving both ICRF-187 and doxorubicin, four died; two after 35 mg/kg, one after 43.75 mg/kg, and one after 52.5 mg/kg; two other dogs were euthanized after 43.75 mg/kg because of difficulties encountered in giving i.v. injections, and two dogs survived a total dose of 52.5 mg/kg. All control dogs survived. None of the treatment or control groups developed consistent echocardiographic changes or alterations in mean arterial pressure. By 300 days after onset of treatment, dogs given ICRF-187 and doxorubicin developed significant prolongation of the PQ interval; by 550 days, surviving dogs in this group developed ventricular premature contractions. Each animal receiving doxorubicin alone had severe myocardial lesions (lesion score 3+). Of the animals given ICRF-187 and doxorubicin, one that received 35 mg/kg doxorubicin had no lesions; of four given 43.75 mg/kg, three had no lesions and one had minimal lesions (lesion score 1+); of three given 52.5 mg/kg, one had minimal (lesion score 1+), and two had moderate (lesion score 2+) lesions. Control animals had no myocardial lesions. Thus, ICRF-187 provided significant protection when administered with doxorubicin over a period of 90 weeks, and made it possible to give doses of doxorubicin which otherwise would have been lethal.
JF  - Cancer research
AU  - Herman, E H
AU  - Ferrans, V J
AU  - Young, R S
AU  - Hamlin, R L
AD  - Division of Drug Biology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/12/01/
PY  - 1988
DA  - 1988 Dec 01
SP  - 6918
EP  - 6925
VL  - 48
IS  - 23
SN  - 0008-5472, 0008-5472
KW  - Piperazines
KW  - 0
KW  - Razoxane
KW  - 5AR83PR647
KW  - Doxorubicin
KW  - 80168379AG
KW  - Index Medicus
KW  - Animals
KW  - Myocardium -- pathology
KW  - Electrocardiography
KW  - Echocardiography
KW  - Body Weight -- drug effects
KW  - Dogs
KW  - Blood -- drug effects
KW  - Male
KW  - Female
KW  - Razoxane -- pharmacology
KW  - Heart -- drug effects
KW  - Doxorubicin -- toxicity
KW  - Piperazines -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-20
N1  - Date created - 1988-12-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - GEN
T1  - Directory of Curriculum Guidelines for Geriatric Education.
AN  - 63134211; ED303687
AB  - This directory contains information on the nature and availability of curriculum guidelines for education and training programs in geriatrics and gerontology. The curriculum guidelines or model curricula were prepared by professional associations or with federal support, most notably through the Administration on Aging or the Health Resources and Services Administration's Bureau of Health Professions. The guide lists geriatric educational materials for the following disciplines: counselors, dental hygienists, dentists, homemakers-home health aides, multidisciplinary, nurses, occupational therapists, optometrists, pharmacists, physicians, physician assistants, psychologists, social workers, and speech, language, and hearing personnel. Descriptions of each set of guidelines include information on discipline, title, sponsor, content, background, source, and price of the materials. An appendix lists geriatric education center grants. (KC)
Y1  - 1988/12//
PY  - 1988
DA  - December 1988
SP  - 40
KW  - ERIC, Resources in Education (RIE)
KW  - Program Descriptions
KW  - Postsecondary Education
KW  - Federal Programs
KW  - Guidelines
KW  - Gerontology
KW  - Geriatrics
KW  - Curriculum Guides
KW  - Standards
KW  - Models
KW  - Health Occupations
KW  - Program Descriptions
KW  - Postsecondary Education
KW  - Federal Programs
KW  - Guidelines
KW  - Gerontology
KW  - Geriatrics
KW  - Curriculum Guides
KW  - Standards
KW  - Models
KW  - Health Occupations
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63134211?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Immunochemical quantitation of DNA adducts derived from the human bladder carcinogen 4-aminobiphenyl.
AN  - 78483792; 3180051
AB  - To assess target-tissue exposure to the human urinary bladder carcinogen 4-aminobiphenyl (ABP), we have developed a sensitive immunochemical method for measuring the major arylamine-DNA adduct formed, N-(guan-8-yl)-ABP (Gua-C8-ABP). High-affinity polyclonal antisera from rabbits immunized with N-(guanosin-8-yl)-ABP coupled to keyhole limpet hemocyanin were characterized and shown to have high specificity for antigenic determinants on the purine and biphenyl rings of Gua-C8-ABP and minimal cross-reactivity with ABP, deoxyguanosine, or hydrolyzed DNA. Assay standards containing ABP-modified DNA were prepared by reacting [3H]N-hydroxy-ABP with calf thymus DNA. DNA samples were hydrolyzed with trifluoroacetic acid and dried under vacuum, and the residues were dissolved in dimethyl sulfoxide under argon. Using a streptavidin-biotin amplified enzyme-linked immunosorbent assay, DNA hydrolysates competed at 25 micrograms DNA/microtiter well for a limiting amount of anti-keyhole limpet hemocyanin-(Gua-C8-ABP) in the presence of excess solid-phase bovine serum albumin-(Gua-C8-ABP) coating antigen. The limit of sensitivity for this assay using 25 micrograms DNA was 2 adducts/10(8) nucleotides. Gua-C8-ABP adducts in liver and bladder epithelial DNAs were readily quantified after p.o. administration of 5 mg/kg ABP to dogs. This methodology is capable of detecting adducts at levels of biological significance and should be applicable to human target-tissue dosimetry.
JF  - Cancer research
AU  - Roberts, D W
AU  - Benson, R W
AU  - Groopman, J D
AU  - Flammang, T J
AU  - Nagle, W A
AU  - Moss, A J
AU  - Kadlubar, F F
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/11/15/
PY  - 1988
DA  - 1988 Nov 15
SP  - 6336
EP  - 6342
VL  - 48
IS  - 22
SN  - 0008-5472, 0008-5472
KW  - Aminobiphenyl Compounds
KW  - 0
KW  - Carcinogens
KW  - Immune Sera
KW  - 4-biphenylamine
KW  - 16054949HJ
KW  - DNA
KW  - 9007-49-2
KW  - Index Medicus
KW  - Animals
KW  - Immune Sera -- immunology
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Rabbits
KW  - Cross Reactions
KW  - Urinary Bladder Neoplasms -- chemically induced
KW  - Carcinogens -- metabolism
KW  - DNA -- metabolism
KW  - DNA -- immunology
KW  - Aminobiphenyl Compounds -- immunology
KW  - Aminobiphenyl Compounds -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-02
N1  - Date created - 1988-12-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - FDA Total Diet Study, April 1982-April 1984, dietary intakes of pesticides, selected elements, and other chemicals.
AN  - 78732081; 3240978
AB  - The U.S. Food and Drug Administration conducts the Total Diet Study to determine dietary intakes of selected pesticides, industrial chemicals, and elements (including radionuclides). The current study, which reflects significant redesign implemented in April 1982, involves retail purchase of foods representative of the "total diet" of the U.S. population, preparation for "table-ready" consumption, and individual analyses of 234 items depicting the diets of 8 population groups. The dietary revision was based on 2 nationwide food consumption surveys. The data presented represent 8 food collections (also termed "market baskets") in regional metropolitan areas during the 2-year period. Dietary intakes of over 100 analytes are presented for the 8 population groups, which range from infants to elderly adults. Intakes of selected population groups are compared with representative previous findings. As in the past, average daily intakes are within acceptable limits.
JF  - Journal - Association of Official Analytical Chemists
AU  - Gunderson, E L
AD  - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204.
PY  - 1988
SP  - 1200
EP  - 1209
VL  - 71
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Elements
KW  - 0
KW  - Pesticides
KW  - Index Medicus
KW  - United States
KW  - United States Food and Drug Administration
KW  - Humans
KW  - Adult
KW  - Male
KW  - Pesticides -- analysis
KW  - Elements -- analysis
KW  - Food Contamination -- analysis
KW  - Diet
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-05-15
N1  - Date created - 1989-05-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Subchronic toxicity study of 1,4-dithiane in the rat.
AN  - 78702873; 2465932
AB  - In a 90-day study, CD strain rats were dosed with 1,4-dithiane by daily gavage at 0, 105, 210, and 420 mg/kg/day (30 rats/sex/dose) in order to calculate a suggested drinking water criterion. No overt toxicity, treatment-related mortality, or ophthalmologic changes were found. Treatment-related decreases were found in female amylase, sorbitol dehydrogenase, and reticulocyte count, and in LDH 1 in both sexes, in LDH 3 in the males, and in LDH 5 in both sexes. Treatment-related increases were found in female liver and in male kidney and male thymus weight. A treatment-related decrease in female brain weight was also found. Significant changes in organ weight of dosed animals compared to control organ weight were observed at the 105 mg/kg/day dose in the spleen of both sexes, female brain, and the male kidneys. Three organs showed compound-related anatomic changes: nose, liver, and kidney. Anisotrophic crystals of undetermined chemical composition were deposited in the olfactory nasal mucosa of both sexes. These crystals were not composed of 1,4-dithiane because 1,4-dithiane is very soluble in ethanol and would not have been present after the slide preparation process. The crystals were present in similar amounts in both sexes of the high and intermediate dose groups. In the low dose group, however, the crystals were present in greater amounts in the females. Crystals were not observed in the control animals. The other treatment-related anatomic abnormalities were eosinophilic cytoplasmic granulation of the convoluted renal tubule cells in the high dose males and minimal hypertrophy of the centrilobular region of the liver in the high dose females. The animal no-observed-effect-level was 105 mg/kg/day. This study reports a novel form of toxicity (deposition of anisotrophic crystals in the olfactory mucosa) from 1,4-dithiane administered by gavage. The chemical composition of the crystals and the absorption, distribution, metabolism, and excretion of 1,4-dithiane are unknown at present.
JF  - Fundamental and applied toxicology : official journal of the Society of Toxicology
AU  - Schieferstein, G J
AU  - Sheldon, W G
AU  - Cantrell, S A
AU  - Reddy, G
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/11//
PY  - 1988
DA  - November 1988
SP  - 703
EP  - 714
VL  - 11
IS  - 4
SN  - 0272-0590, 0272-0590
KW  - Water Pollutants
KW  - 0
KW  - L-Iditol 2-Dehydrogenase
KW  - EC 1.1.1.14
KW  - L-Lactate Dehydrogenase
KW  - EC 1.1.1.27
KW  - Amylases
KW  - EC 3.2.1.-
KW  - Index Medicus
KW  - Eating -- drug effects
KW  - Animals
KW  - Nasal Mucosa -- pathology
KW  - Liver -- pathology
KW  - Kidney -- pathology
KW  - L-Lactate Dehydrogenase -- analysis
KW  - Rats
KW  - Drinking -- drug effects
KW  - L-Iditol 2-Dehydrogenase -- blood
KW  - Body Weight -- drug effects
KW  - Reticulocytes -- metabolism
KW  - Amylases -- blood
KW  - Female
KW  - Male
KW  - Organ Size -- drug effects
KW  - Water Pollutants -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-04-17
N1  - Date created - 1989-04-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Incidence of laryngeal cancer and exposure to acid mists.
AN  - 78595409; 3203082
AB  - To determine the relation between exposure to acid mist and laryngeal cancer, the smoking habits, drinking habits, and incidence of laryngeal cancer of 879 male steelworkers exposed to acid mists during pickling operations was ascertained. Sulphuric acid mist was the primary exposure for most men in this cohort. These men had all worked in a pickling operation for a minimum of six months before 1965, with an average duration of exposure of 9.5 years. Exposures to sulphuric acid in the 1970s averaged about 0.2 mg/m3, and earlier exposures were probably similar. Interviews were conducted with all cohort members or their next of kin in 1986 and medical records of decedents were reviewed. Nine workers were identified who had been diagnosed as having laryngeal cancer, using a conservative case definition that required medical record confirmation for any case among decedents and confirmation by a physician for any case among live individuals. Using data from national surveys of cancer incidence as referent rates, 3.44 laryngeal cancers would have been expected. Excess smoking by the exposed cohort compared with the United States population resulted in an upward adjustment of the expected number of cases of laryngeal cancer to 3.92. The standardised incidence rate ratio for laryngeal cancer was 2.30 (9/3.92), with a one sided p value of 0.01 (assuming a Poisson distribution). The finding of excess laryngeal cancer in this cohort is consistent with four other studies published since 1981.
JF  - British journal of industrial medicine
AU  - Steenland, K
AU  - Schnorr, T
AU  - Beaumont, J
AU  - Halperin, W
AU  - Bloom, T
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988/11//
PY  - 1988
DA  - November 1988
SP  - 766
EP  - 776
VL  - 45
IS  - 11
SN  - 0007-1072, 0007-1072
KW  - Sulfuric Acids
KW  - 0
KW  - Index Medicus
KW  - California
KW  - Humans
KW  - Cohort Studies
KW  - Smoking -- adverse effects
KW  - Alcohol Drinking
KW  - Male
KW  - Laryngeal Neoplasms -- chemically induced
KW  - Sulfuric Acids -- adverse effects
KW  - Laryngeal Neoplasms -- epidemiology
KW  - Occupational Diseases -- epidemiology
KW  - Occupational Diseases -- chemically induced
KW  - Metallurgy
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+industrial+medicine&rft.atitle=Incidence+of+laryngeal+cancer+and+exposure+to+acid+mists.&rft.au=Steenland%2C+K%3BSchnorr%2C+T%3BBeaumont%2C+J%3BHalperin%2C+W%3BBloom%2C+T&rft.aulast=Steenland&rft.aufirst=K&rft.date=1988-11-01&rft.volume=45&rft.issue=11&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=British+journal+of+industrial+medicine&rft.issn=08876134&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-02-08
N1  - Date created - 1989-02-08
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Cancer. 1976 Oct;38(4):1591-601 [991080]
J Occup Med. 1976 Nov;18(11):743-54 [993866]
Epidemiol Rev. 1980;2:195-209 [7000536]
Med Hypotheses. 1981 Jul;7(7):951-6 [7289910]
J Natl Cancer Inst. 1986 Jun;76(6):1057-63 [3458944]
Am J Epidemiol. 1984 Sep;120(3):358-69 [6475913]
Environ Res. 1984 Oct;35(1):1-10 [6489281]
Am J Epidemiol. 1985 Jan;121(1):131-9 [3964988]
Environ Health Perspect. 1985 Nov;63:25-38 [3908089]
J Occup Med. 1983 Feb;25(2):115-24 [6687607]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury.
AN  - 78590673; 2849348
AB  - Data presented here indicate that freshly fractured silica exhibits surface characteristics and biologic reactivity distinct from aged silica, and on this basis we propose that these surface features may lead to enhanced manifestations of lung injury. Grinding of silica produces approximately 10(18) Si and Si-O (silicon-based) radicals per gram of dust on the particulate surface which are characterized by an electron spin resonance (ESR) spectrum centered around g = 2.0015. These silicon-based radicals react with aqueous media to produce OH radicals, which are demonstrable using a DMPO spin trap. The concentration of silicon-based radicals in silica decreases with aging in air and exhibits a half-life of approximately 30 h, whereas its ability to generate OH radicals in aqueous solution decreases with a half-life of approximately 20 h. However, on storage in aqueous media, the concentration of silicon-based radicals and the dust's ability to generate OH radicals decrease significantly within a few minutes. Freshly ground silica is also more biologically reactive than aged silica, because freshly crushed silica activates a greater respiratory burst in alveolar macrophages than aged silica, i.e., storage of ground dust in air decreases silica-induced superoxide anion secretion, hydrogen peroxide release, and NBT reduction by 25%, 68%, and 43%, respectively. Furthermore, compared to aged silica, freshly ground silica exhibits a greater cytotoxic effect on cellular membrane integrity, i.e., a 1.5-fold increase in LDH release from macrophages, a 36-fold increase in hemolytic activity, and a three-fold increase in the ability to induce lipid peroxidation.(ABSTRACT TRUNCATED AT 250 WORDS)
JF  - The American review of respiratory disease
AU  - Vallyathan, V
AU  - Shi, X L
AU  - Dalal, N S
AU  - Irr, W
AU  - Castranova, V
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV.
Y1  - 1988/11//
PY  - 1988
DA  - November 1988
SP  - 1213
EP  - 1219
VL  - 138
IS  - 5
SN  - 0003-0805, 0003-0805
KW  - Dust
KW  - 0
KW  - Free Radicals
KW  - Lipid Peroxides
KW  - Silicon Dioxide
KW  - 7631-86-9
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Acute Disease
KW  - Macrophages -- enzymology
KW  - Animals
KW  - Chemistry
KW  - Macrophages -- drug effects
KW  - Lipid Peroxides -- biosynthesis
KW  - Pulmonary Alveoli -- metabolism
KW  - Cells, Cultured
KW  - Electron Spin Resonance Spectroscopy
KW  - Chemical Phenomena
KW  - Pulmonary Alveoli -- drug effects
KW  - Pulmonary Alveoli -- cytology
KW  - Dust -- adverse effects
KW  - Surface Properties
KW  - Macrophages -- metabolism
KW  - Silicon Dioxide -- pharmacology
KW  - Lung Diseases -- etiology
KW  - Silicon Dioxide -- metabolism
KW  - Lung Diseases -- metabolism
KW  - Silicon Dioxide -- adverse effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78590673?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Generation+of+free+radicals+from+freshly+fractured+silica+dust.+Potential+role+in+acute+silica-induced+lung+injury.&rft.au=Vallyathan%2C+V%3BShi%2C+X+L%3BDalal%2C+N+S%3BIrr%2C+W%3BCastranova%2C+V&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=1988-11-01&rft.volume=138&rft.issue=5&rft.spage=1213&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-24
N1  - Date created - 1989-01-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Relationships among direct-acting mutagenicity, nitro group orientation and polarographic reduction potential of 6-nitrobenzo[a]pyrene, 7-nitrobenz[a]anthracene and their derivatives.
AN  - 78557382; 3057374
AB  - The direct-acting mutagenicity in Salmonella typhimurium strains TA98 and TA100 and the half-wave reduction potentials of 6-nitrobenzo[a]pyrene (6-nitro-BaP), 7-nitrobenz[a]anthracene (7-nitro-BA), and a series of their derivatives were compared. The common structural feature of these compounds is that their nitro substituents, in order to minimize steric hindrance, preferentially adopt an orientation perpendicular or nearly perpendicular to the aromatic rings. All of the compounds, except 7-hydroxy-6-nitro-BaP and 7-acetoxy-6-nitro-BaP, were found to exhibit very weak or no direct-acting mutagenicity. 7-Acetoxy-6-nitro-BaP and 7-hydroxy-6-nitro-BaP were also found to have the lowest reduction potentials among the tested compounds. The results suggest that a combination of the orientation of the nitro substituent and the first half-wave reduction potential of the compound may correlate with the direct-acting bacterial mutagenicity of nitro-polycyclic aromatic hydrocarbons.
JF  - Mutation research
AU  - Fu, P P
AU  - Heflich, R H
AU  - Unruh, L E
AU  - Shaikh, A U
AU  - Wu, Y S
AU  - Lai, C C
AU  - Lai, J S
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
PY  - 1988
SP  - 115
EP  - 122
VL  - 209
IS  - 3-4
SN  - 0027-5107, 0027-5107
KW  - Benz(a)Anthracenes
KW  - 0
KW  - Benzopyrenes
KW  - Mutagens
KW  - 7-nitrobenzanthracene
KW  - 20268-51-3
KW  - 6-nitrobenzo(a)pyrene
KW  - 63041-90-7
KW  - Index Medicus
KW  - Oxidation-Reduction
KW  - Molecular Structure
KW  - Mutagenicity Tests
KW  - Polarography
KW  - Salmonella typhimurium -- drug effects
KW  - Benzopyrenes -- pharmacology
KW  - Benz(a)Anthracenes -- pharmacology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78557382?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Relationships+among+direct-acting+mutagenicity%2C+nitro+group+orientation+and+polarographic+reduction+potential+of+6-nitrobenzo%5Ba%5Dpyrene%2C+7-nitrobenz%5Ba%5Danthracene+and+their+derivatives.&rft.au=Fu%2C+P+P%3BHeflich%2C+R+H%3BUnruh%2C+L+E%3BShaikh%2C+A+U%3BWu%2C+Y+S%3BLai%2C+C+C%3BLai%2C+J+S&rft.aulast=Fu&rft.aufirst=P&rft.date=1988-11-01&rft.volume=209&rft.issue=3-4&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-06
N1  - Date created - 1989-01-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Nitroreduction of 6-nitrobenzo[a]pyrene: a potential activation pathway in humans.
AN  - 78554365; 3057375
AB  - 6-Nitrobenzo[a]pyrene, an environmental pollutant, was metabolized by human intestinal microflora to 6-nitrosobenzo[a]pyrene and 6-aminobenzo[a]pyrene. The two-electron reduction product 6-nitrosobenzo[a]pyrene exhibited strong direct-acting mutagenicity in the Salmonella typhimurium assay. These results imply that 6-nitrobenzo[a]pyrene can be hazardous to human health via a nitroreduction activation pathway and opens the possibility that other nitro-polycyclic aromatic hydrocarbons that are not direct-acting mutagens may be activated in vivo by a similar mechanism.
JF  - Mutation research
AU  - Fu, P P
AU  - Cerniglia, C E
AU  - Richardson, K E
AU  - Heflich, R H
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
PY  - 1988
SP  - 123
EP  - 129
VL  - 209
IS  - 3-4
SN  - 0027-5107, 0027-5107
KW  - Benzopyrenes
KW  - 0
KW  - Mutagens
KW  - 6-nitrobenzo(a)pyrene
KW  - 63041-90-7
KW  - 6-aminobenzo(a)pyrene
KW  - 7428-83-3
KW  - Index Medicus
KW  - Mutagenicity Tests
KW  - Humans
KW  - Salmonella typhimurium -- drug effects
KW  - Intestines -- microbiology
KW  - Benzopyrenes -- metabolism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Nitroreduction+of+6-nitrobenzo%5Ba%5Dpyrene%3A+a+potential+activation+pathway+in+humans.&rft.au=Fu%2C+P+P%3BCerniglia%2C+C+E%3BRichardson%2C+K+E%3BHeflich%2C+R+H&rft.aulast=Fu&rft.aufirst=P&rft.date=1988-11-01&rft.volume=209&rft.issue=3-4&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-06
N1  - Date created - 1989-01-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Raising public awareness about the extent of alcohol-related problems: an overview.
AN  - 78528893; 3141947
JF  - Public health reports (Washington, D.C. : 1974)
AU  - Bowen, O R
AD  - Department of Health and Human Services. News Division, Office of Public Affairs, Washington, DC 20201.
PY  - 1988
SP  - 559
EP  - 563
VL  - 103
IS  - 6
SN  - 0033-3549, 0033-3549
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Costs and Cost Analysis
KW  - Humans
KW  - Adult
KW  - United States Dept. of Health and Human Services
KW  - Adolescent
KW  - Female
KW  - Pregnancy
KW  - Attitude to Health
KW  - Health Education -- methods
KW  - Alcoholism -- economics
KW  - Alcoholism -- prevention & control
KW  - Alcoholism -- complications
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78528893?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Raising+public+awareness+about+the+extent+of+alcohol-related+problems%3A+an+overview.&rft.au=Bowen%2C+O+R&rft.aulast=Bowen&rft.aufirst=O&rft.date=1988-11-01&rft.volume=103&rft.issue=6&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-12
N1  - Date created - 1988-12-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The Indian Health Service approach to alcoholism among American Indians and Alaska Natives.
AN  - 78518660; 3141956
AB  - The transfer to the Indian Health Service (IHS) of 158 alcohol treatment programs that had been administered by the National Institute on Alcohol Abuse and Alcoholism began in 1978. Today, approximately 300 alcohol and substance abuse treatment programs offer services to American Indians, among them primary residential treatment, halfway houses, outreach, and aftercare. This system provides a national network upon which additional activities may be established. Along with increasing its attention to health promotion and disease prevention, the IHS has moved toward the prevention of alcoholism. A variety of preventive programs are in place that emphasize improved self-image, value and attitude clarification, decision-making, and physical and emotional effects of alcohol and substance abuse. Many begin as Head Start programs and continue through adulthood. In 1986, after consulting with both academic and tribal experts, the IHS devised a strategic plan for alcoholism control that stresses comprehensive care and prevention activities; it serves as a guide for further program development. The Secretary of Health and Human Services created a Task Force on Indian Alcoholism in 1986 to serve as a coordinating body for activities carried out by the IHS and other agencies and units of the Department. Passage of the Anti-Drug Abuse Act in 1986 added resources for the development of adolescent treatment centers and, more importantly, for community-based pre- and post-residential care for youths and their families. Concomitant with these initiatives have been several instances of increased attention by various tribes to the problem of alcoholism. The IHS strategic plan, together with the Secretary's initiative, the Anti-Drug Act, and tribal actions, has added substantial momentum to efforts directed at controlling alcoholism among American Indians. Although the mortality rate from alcoholism is about four times greater for the American Indian population than for the entire U.S. population, it decreased from 54.5 per 100,000 population to 26.1 between 1978 and 1985-a reduction of 52 percent.The philosophy of the IHS in emphasizing prevention of disease and promotion of wellness provides an opportunity for continuing the considerable progress already made. The critical and decisive role played by the Indian communities themselves will determine whether ultimate success can be achieved.
JF  - Public health reports (Washington, D.C. : 1974)
AU  - Rhoades, E R
AU  - Mason, R D
AU  - Eddy, P
AU  - Smith, E M
AU  - Burns, T R
AD  - Indian Health Service, Rockville, MD.
PY  - 1988
SP  - 621
EP  - 627
VL  - 103
IS  - 6
SN  - 0033-3549, 0033-3549
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Curriculum
KW  - Adult
KW  - United States Dept. of Health and Human Services
KW  - Child
KW  - Alaska
KW  - Health Education -- methods
KW  - Adolescent
KW  - Inuits
KW  - Indians, North American
KW  - Health Services, Indigenous -- organization & administration
KW  - Alcoholism -- mortality
KW  - Alcoholism -- ethnology
KW  - Alcoholism -- prevention & control
KW  - Preventive Health Services -- organization & administration
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-12
N1  - Date created - 1988-12-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Public Health Rep. 1987 Jul-Aug;102(4):361-8 [3112844]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Screening for alcoholism: techniques and issues.
AN  - 78518614; 3141951
AB  - Alcoholism is an often overlooked health problem because alcoholics usually do not seek treatment for their drinking problems. They do, however, seek general medical care for other health reasons, and a number of screening techniques have proven useful for identifying alcoholics. The advantages and disadvantages of self-report, as well as biochemical techniques that have been found effective in screening for alcoholism, are discussed. We recommend that future research be aimed at developing quick, accurate, and inexpensive screening devices that also can evaluate the severity of the alcohol problem. Ideally, screening procedures would discourage feigned responses, differentiate between drinking and consequences of drinking, and permit the identification of subtypes of alcoholics. Better understanding of the types of errors made by common screening instruments would enable researchers to construct an optimal sequencing strategy for screening for alcoholism.
JF  - Public health reports (Washington, D.C. : 1974)
AU  - Allen, J P
AU  - Eckardt, M J
AU  - Wallen, J
AD  - National Institute on Alcohol Abuse and Alcoholism, Public Health Service, Rockville, MD 20857.
PY  - 1988
SP  - 586
EP  - 592
VL  - 103
IS  - 6
SN  - 0033-3549, 0033-3549
KW  - Biomarkers
KW  - 0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Humans
KW  - Biomarkers -- analysis
KW  - MMPI
KW  - Adult
KW  - Self-Assessment
KW  - Research
KW  - Adolescent
KW  - Alcoholism -- diagnosis
KW  - Alcoholism -- metabolism
KW  - Alcoholism -- psychology
KW  - Psychological Tests
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Screening+for+alcoholism%3A+techniques+and+issues.&rft.au=Allen%2C+J+P%3BEckardt%2C+M+J%3BWallen%2C+J&rft.aulast=Allen&rft.aufirst=J&rft.date=1988-11-01&rft.volume=103&rft.issue=6&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-12
N1  - Date created - 1988-12-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Clin Chim Acta. 1972 Jun;39(1):41-7 [5038763]
Am J Psychiatry. 1971 Jun;127(12):1653-8 [5565851]
Am J Med Sci. 1974 May;267(5):281-9 [4833835]
Mayo Clin Proc. 1975 Apr;50(4):204-8 [1123936]
Am J Gastroenterol. 1976 Apr;65(4):318-23 [7137]
Science. 1976 Dec 3;194(4269):1057-8 [824734]
Lancet. 1978 May 6;1(8071):978-81 [76902]
Ann Clin Biochem. 1978 Nov;15(6):297-303 [32826]
Clin Chem. 1979 Jul;25(7):1242-6 [37002]
Res Commun Chem Pathol Pharmacol. 1980 Mar;27(3):533-50 [7384642]
JAMA. 1981 May 1;245(17):1748-51 [6111616]
JAMA. 1981 Dec 11;246(23):2707-10 [6118443]
Am J Epidemiol. 1981 Dec;114(6):862-72 [6119025]
Comput Biomed Res. 1982 Jun;15(3):228-39 [7049561]
JAMA. 1982 Nov 12;248(18):2261-5 [7131677]
JAMA. 1982 Nov 12;248(18):2342-5 [7131692]
Arch Gen Psychiatry. 1983 Jun;40(6):620-5 [6847331]
Lancet. 1983 Sep 3;2(8349):534-7 [6136692]
J Clin Chem Clin Biochem. 1984 Jan;22(1):79-96 [6142078]
Arch Gen Psychiatry. 1984 Oct;41(10):971-8 [6477055]
Br J Addict. 1986 Feb;81(1):23-46 [3457598]
J Biol Chem. 1986 May 25;261(15):6811-21 [3700416]
J Stud Alcohol. 1986 May;47(3):228-36 [3724159]
Br Med J (Clin Res Ed). 1986 Jun 28;292(6537):1703-8 [3089362]
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):3-12 [3099350]
Alcohol Clin Exp Res. 1986 Oct;10(5):535-44 [3099592]
Alcohol Clin Exp Res. 1987 Oct;11(5):468-73 [3314562]
Hepatology. 1987 Nov-Dec;7(6):1210-4 [2445642]
N Engl J Med. 1988 Jan 21;318(3):134-9 [3336400]
J Clin Invest. 1988 Feb;81(2):615-9 [3123522]
Alcohol Clin Exp Res. 1988 Jun;12(3):427-32 [3044175]
Q J Stud Alcohol. 1965 Jun;26:238-46 [14320345]
Lancet. 1974 May 4;1(7862):829-31 [4132788]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The economic impact of alcohol abuse and alcoholism.
AN  - 78517098; 3141948
AB  - The economic effects of alcohol abuse are as damaging to the nation as the health effects, affecting the family, the community, and persons of all ages. Underaged drinking is interfering with children's development, affecting the nation's ability to respond to economic challenge in the future. The college aged may be the most difficult to educate about alcohol abuse because of drinking patterns established at an early age and susceptibility to advertising inducements. Health care costs for families with an alcoholic member are twice those for families without one, and up to half of all emergency room admissions are alcohol related. Fetal alcohol syndrome is one of the top three known causes of birth defects, and is totally preventable. Alcohol abuse and alcoholism are estimated to have cost the nation $117 billion in 1983, while nonalcoholic drug abuse that year cost $60 billion. Costs of alcohol abuse are expected to be $136 billion a year by 1990, mostly from lost productivity and employment. Between 6 and 7 million workers are alcoholic, with an undetermined loss of productivity, profits, and competitiveness of American business. Alcohol abuse contributes to the high health care costs of the elderly beneficiaries of Federal health financing programs. Heavily affected minorities include blacks, Hispanics, and Native Americans. Society tends to treat the medical and social consequences of alcohol abuse, rather than its causes. Although our experience with the consequences of alcohol abuse is greater than that for any other drug, public concern for its prevention and treatment is less than for other major illnesses or abuse of other drugs. Alcohol abuse is a problem being given high priority within the Department in an effort to create a national agenda on the issue and to try to impart a greater sense of urgency about the problems. Ways are being explored to integrate alcoholism activities into more Departmental programs. Employee assistance programs for alcohol abuse have been established in about 90 percent of major companies, and Federal employees' access to treatment is being expanded through health insurance coverage. Collective public efforts are required to encourage prevention and treatment efforts, and to begin to reduce the economic effects of alcohol abuse that the country can no longer afford.
JF  - Public health reports (Washington, D.C. : 1974)
AU  - Burke, T R
AD  - Department of Health and Human Services, Washington, DC 20201.
PY  - 1988
SP  - 564
EP  - 568
VL  - 103
IS  - 6
SN  - 0033-3549, 0033-3549
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Costs and Cost Analysis
KW  - Humans
KW  - Occupational Health Services -- organization & administration
KW  - Adult
KW  - United States Dept. of Health and Human Services
KW  - Child
KW  - Adolescent
KW  - Morbidity
KW  - Health Expenditures
KW  - Alcoholism -- economics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-12
N1  - Date created - 1988-12-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Monooctanoin-associated pulmonary edema.
AN  - 85226525; pmid-3048083
AB  - Monooctanoin is a cholesterol solvent indicated for dissolution of retained biliary stones. We summarize four reports--one from the U.S. Food and Drug Administration's Spontaneous Reporting System for Adverse Drug Reactions and three from published medical literature--of noncardiogenic pulmonary edema during intrabiliary monooctanoin in the United States. Based on these data, we show that pulmonary edema during intrabiliary monooctanoin infusion may occur in approximately one per 1000 patients treated.
JF  - The American Journal of Gastroenterology
AU  - Hine, L K
AU  - Arrowsmith, J B
AU  - Gallo-Torres, H E
AD  - Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Maryland.
PY  - 1988
SP  - 1128
EP  - 1131
VL  - 83
IS  - 10
SN  - 0002-9270, 0002-9270
KW  - Glycerides
KW  - Cholelithiasis
KW  - Pulmonary Edema
KW  - Human
KW  - Adult
KW  - Solvents
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226525?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Monooctanoin-associated+pulmonary+edema.&rft.au=Hine%2C+L+K%3BArrowsmith%2C+J+B%3BGallo-Torres%2C+H+E&rft.aulast=Hine&rft.aufirst=L&rft.date=1988-10-01&rft.volume=83&rft.issue=10&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/
LA  - eng
DB  - ComDisDome
N1  - Last updated - 2010-05-07
ER  - 



TY  - JOUR
T1  - The FDA and the physician.
AN  - 85224687; pmid-3421218
JF  - The American Journal of Gastroenterology
AU  - Fredd, S
AD  - Division of Gastrointestinal and Coagulation Drug Products, Food and Drug Administration, Rockville, Maryland.
PY  - 1988
SP  - 1088
EP  - 1090
VL  - 83
IS  - 10
SN  - 0002-9270, 0002-9270
KW  - Goals
KW  - United States
KW  - Physician's Role
KW  - United States Food and Drug Administration
KW  - Physicians
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224687?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=The+FDA+and+the+physician.&rft.au=Fredd%2C+S&rft.aulast=Fredd&rft.aufirst=S&rft.date=1988-10-01&rft.volume=83&rft.issue=10&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/
LA  - eng
DB  - ComDisDome
N1  - Last updated - 2010-05-07
ER  - 



TY  - JOUR
T1  - Contemporary issues: diseases with a food vector.
AN  - 78704442; 3069199
AB  - Foodborne disease has become a contemporary issue. Several large, well-publicized outbreaks of foodborne disease have heightened public awareness that harmful microorganisms may be present in food and that chronic as well as acute disease may be caused by foodborne microbes. The field of food microbiology has likewise experienced a resurgence of interest. New tools, such as recombinant deoxyribonucleic acid technology and monoclonal antibody production, used to elucidate microbial virulence factors have facilitated identification of disease-causing microbes once thought to be harmless and demonstrated the complexity of individual virulence mechanisms previously considered to be well understood. Foodborne pathogens are also causing disease via some surprising food vectors, such as chopped, bottled garlic and sauteed onions. In addition to acute gastrointestinal disturbances, certain microorganisms may, through complex interactions with the human immune response, cause chronic diseases that affect several major organ systems. These microbes are serving as models in studies of molecular mimicry and genetic interrelatedness of procaryotes and eucaryotes. Other recently recognized attributes of foodborne microorganisms, such as the heat shock phenomenon and the possible nonculturability of some bacteria, may affect their ability to cause disease in humans. Because foodborne disease is a major cause of morbidity and mortality, the study of these diseases and their causative microorganisms presents a unique challenge to many professionals in the subdisciplines of microbiology, epidemiology, and clinical medicine.
JF  - Clinical microbiology reviews
AU  - Archer, D L
AU  - Young, F E
AD  - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 377
EP  - 398
VL  - 1
IS  - 4
SN  - 0893-8512, 0893-8512
KW  - Bacterial Toxins
KW  - 0
KW  - Index Medicus
KW  - Enterobacteriaceae -- isolation & purification
KW  - Protozoan Infections -- etiology
KW  - Gastroenteritis -- microbiology
KW  - Humans
KW  - Staphylococcal Food Poisoning -- microbiology
KW  - Virus Diseases -- etiology
KW  - Food Microbiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78704442?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+microbiology+reviews&rft.atitle=Contemporary+issues%3A+diseases+with+a+food+vector.&rft.au=Archer%2C+D+L%3BYoung%2C+F+E&rft.aulast=Archer&rft.aufirst=D&rft.date=1988-10-01&rft.volume=1&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Clinical+microbiology+reviews&rft.issn=08938512&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-05-02
N1  - Date created - 1989-05-02
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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J Clin Microbiol. 1987 Jan;25(1):110-4 [3539984]
J Infect. 1986 Nov;13(3):235-9 [3098856]
J Pediatr Gastroenterol Nutr. 1987 Jan-Feb;6(1):135-40 [3794927]
J Med Microbiol. 1986 Dec;22(4):367-77 [3098979]
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J Appl Bacteriol. 1986 Nov;61(5):389-93 [3542923]
J Infect Dis. 1987 Mar;155(3):377-89 [3543152]
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Lancet. 1987 Feb 7;1(8528):331-2 [2880146]
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Rev Infect Dis. 1984 Mar-Apr;6(2):200-13 [6374835]
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Microbiol Rev. 1984 Jun;48(2):157-79 [6330511]
Immunology. 1984 Aug;52(4):607-10 [6378768]
Ann Intern Med. 1984 Sep;101(3):339-41 [6431862]
J Infect Dis. 1984 Sep;150(3):380-8 [6384378]
Am J Med. 1984 Nov;77(5):961-7 [6333819]
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Infect Immun. 1984 Nov;46(2):435-41 [6500697]
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J Infect Dis. 1986 Aug;154(2):376 [3722874]
JAMA. 1986 Jul 25;256(4):469 [3723735]
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Lab Invest. 1986 Jul;55(1):5-24 [3014215]
Medicine (Baltimore). 1986 Jul;65(4):218-25 [3724434]
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Am J Epidemiol. 1986 Aug;124(2):299-305 [3524201]
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Clin Exp Immunol. 1986 May;64(2):249-54 [3017619]
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J Infect. 1986 Sep;13(2):187-93 [3093591]
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Infect Immun. 1985 Dec;50(3):869-76 [2866161]
Infection. 1985 Sep-Oct;13(5):228-30 [4066046]
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Pediatrics. 1987 Apr;79(4):559-63 [3029660]
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J Immunol. 1987 Apr 1;138(7):2266-71 [3104455]
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Infect Immun. 1987 May;55(5):1176-83 [3570459]
Int Arch Allergy Appl Immunol. 1987;82(3-4):289-91 [3032802]
J Clin Microbiol. 1987 Apr;25(4):702-5 [3553233]
J Pediatr. 1987 May;110(5):705-9 [2437277]
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J Pediatr. 1987 Jun;110(6):894-7 [3295160]
J Infect Dis. 1987 Jul;156(1):218-22 [3598217]
J Exp Med. 1987 Jul 1;166(1):173-81 [2439632]
Pediatrics. 1987 Jul;80(1):37-40 [3299236]
Pediatrics. 1987 Jul;80(1):41-5 [3601516]
J Clin Microbiol. 1987 Jul;25(7):1248-52 [3611317]
J Infect Dis. 1987 Sep;156(3):526-7 [3497211]
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Am J Public Health. 1987 Sep;77(9):1219-21 [3618859]
Cell. 1987 Aug 28;50(5):769-78 [3304658]
Cell. 1987 Sep 11;50(6):819-20 [3621346]
Infect Immun. 1987 Sep;55(9):2247-54 [2887516]
JAMA. 1987 Sep 18;258(11):1496-9 [3625949]
Lancet. 1987 Sep 12;2(8559):589-93 [2887886]
Medicine (Baltimore). 1987 Sep;66(5):349-88 [3306260]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Evaluation of propanil and its N-oxidized derivatives for genotoxicity in the Salmonella typhimurium reversion, Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase, and rat hepatocyte/DNA repair assays.
AN  - 78650272; 3065118
AB  - Since the herbicide propanil (3,4-dichloropropionanilide) is an aromatic amide and many other aromatic amides are genotoxic via N-hydroxy (N-OH) metabolites, N-oxidized derivatives of propanil and 3,4-dichloroaniline were synthesized and tested for genotoxicity. Propanil 3,4-dichloroaniline, and their N-OH derivatives were not mutagenic in the Salmonella typhimurium reversion assay using tester strains TA97, TA98, TA100, and TA104, in both the presence and absence of exogenous metabolic activation (S9). In addition, the test compounds were not mutagenic in the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase (CHO/HGPRT) assay, in both the presence and absence of S9. 3,3',4,4'-Tetrachloroazobenzene (TCAB) and its azoxy derivative (TCAOB), which are synthetic contaminants and/or degradation products of propanil, were also inactive in the S. typhimurium reversion and CHO/HGPRT assays (+/- S9). Unscheduled DNA synthesis (UDS) assays were performed to determine if propanil derivatives were able to induce DNA damage in primary rat hepatocytes. Although TCAB was the only derivative tested which induced an elevation in DNA repair, the extent was not statistically significant. Hepatocyte toxicity, as measured by the release of lactate dehydrogenase 24 hr after exposure, was induced by all the test compounds in a concentration-dependent manner. Incubations of [14C]N-OH-3,4-dichloroaniline with DNA in vitro resulted in only a low level of binding that was not affected by pH. This observation may partially explained the lack of mutagenicity observed in genotoxicity assays with propanil derivatives.
JF  - Fundamental and applied toxicology : official journal of the Society of Toxicology
AU  - McMillan, D C
AU  - Shaddock, J G
AU  - Heflich, R H
AU  - Casciano, D A
AU  - Hinson, J A
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 429
EP  - 439
VL  - 11
IS  - 3
SN  - 0272-0590, 0272-0590
KW  - Anilides
KW  - 0
KW  - Mutagens
KW  - Propanil
KW  - 709-98-8
KW  - DNA
KW  - 9007-49-2
KW  - L-Lactate Dehydrogenase
KW  - EC 1.1.1.27
KW  - Hypoxanthine Phosphoribosyltransferase
KW  - EC 2.4.2.8
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Oxidation-Reduction
KW  - Animals
KW  - Mutagenicity Tests
KW  - Cricetulus
KW  - DNA -- metabolism
KW  - Salmonella typhimurium -- drug effects
KW  - Salmonella typhimurium -- genetics
KW  - Male
KW  - L-Lactate Dehydrogenase -- metabolism
KW  - Female
KW  - Cricetinae
KW  - Liver -- enzymology
KW  - Liver -- cytology
KW  - Hypoxanthine Phosphoribosyltransferase -- genetics
KW  - Propanil -- analogs & derivatives
KW  - Liver -- metabolism
KW  - Anilides -- toxicity
KW  - Propanil -- toxicity
KW  - DNA Repair -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-22
N1  - Date created - 1989-03-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Pyrene degradation by a Mycobacterium sp.: identification of ring oxidation and ring fission products.
AN  - 78584593; 3202634
AB  - The degradation of pyrene, a polycyclic aromatic hydrocarbon containing four aromatic rings, by pure cultures of a Mycobacterium sp. was studied. Over 60% of [14C]pyrene was mineralized to CO2 after 96 h of incubation at 24 degrees C. High-pressure liquid chromatography analyses showed the presence of one major and at least six other metabolites that accounted for 95% of the total organic-extractable 14C-labeled residues. Analyses by UV, infrared, mass, and nuclear magnetic resonance spectrometry and gas chromatography identified both pyrene cis- and trans-4,5-dihydrodiols and pyrenol as initial microbial ring-oxidation products of pyrene. The major metabolite, 4-phenanthroic acid, and 4-hydroxyperinaphthenone and cinnamic and phthalic acids were identified as ring fission products. 18O2 studies showed that the formation of cis- and trans-4,5-dihydrodiols were catalyzed by dioxygenase and monooxygenase enzymes, respectively. This is the first report of the chemical pathway for the microbial catabolism of pyrene.
JF  - Applied and environmental microbiology
AU  - Heitkamp, M A
AU  - Freeman, J P
AU  - Miller, D W
AU  - Cerniglia, C E
AD  - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 2556
EP  - 2565
VL  - 54
IS  - 10
SN  - 0099-2240, 0099-2240
KW  - Pyrenes
KW  - 0
KW  - Oxygenases
KW  - EC 1.13.-
KW  - Index Medicus
KW  - Oxidation-Reduction
KW  - Mass Spectrometry
KW  - Chemistry
KW  - Oxygenases -- metabolism
KW  - Kinetics
KW  - Chemical Phenomena
KW  - Gas Chromatography-Mass Spectrometry
KW  - Circular Dichroism
KW  - Chromatography, Thin Layer
KW  - Biodegradation, Environmental
KW  - Chromatography, High Pressure Liquid
KW  - Magnetic Resonance Spectroscopy
KW  - Pyrenes -- metabolism
KW  - Mycobacterium -- metabolism
KW  - Mycobacterium -- enzymology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-25
N1  - Date created - 1989-01-25
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Pharmacol Rev. 1966 Mar;18(1):71-5 [4285737]
Appl Environ Microbiol. 1988 Oct;54(10):2549-55 [3202633]
Science. 1975 Jul 25;189(4199):295-7 [1145203]
Eur J Biochem. 1975 Sep 1;57(1):241-56 [240720]
J Chem Soc Perkin 1. 1975;(23):2506-11 [1239455]
Infect Immun. 1979 Jun;24(3):979-81 [468387]
Cancer Lett. 1981 Jan;11(3):215-20 [7018664]
Cancer. 1981 May 15;47(10):2327-45 [7272889]
Xenobiotica. 1982 Jan;12(1):45-53 [7090418]
Appl Environ Microbiol. 1982 May;43(5):1070-5 [7103474]
Xenobiotica. 1983 Jul;13(7):415-20 [6659544]
Appl Environ Microbiol. 1984 Jan;47(1):119-24 [6696409]
Adv Appl Microbiol. 1984;30:31-71 [6442534]
Biomed Mass Spectrom. 1985 Apr;12(4):151-8 [2861861]
Chem Biol Interact. 1986 Feb;57(2):203-16 [3955791]
Environ Mutagen. 1986;8 Suppl 7:1-119 [3516675]
Carcinogenesis. 1986 Jul;7(7):1135-41 [3719909]
Appl Environ Microbiol. 1987 Jan;53(1):129-36 [3827241]
Appl Environ Microbiol. 1988 Jun;54(6):1612-4 [3415226]
J Biol Chem. 1966 Jul 25;241(14):3308-15 [5913119]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Californium-252 plasma desorption mass spectrometry of aminoglycoside antibiotics.
AN  - 78533800; 3191259
AB  - This paper presents mass spectral data of eleven aminoglycoside antibiotics by using californium-252 plasma desorption (252Cf PD) mass spectrometry. This mass spectral data could be used to develop a confirmatory method for monitoring aminoglycoside antibiotic residues isolated from food products of animal origin. Mass spectra were determined by applying time-of-flight 252Cf PD mass spectrometry to eleven aminoglycoside antibiotics, namely: neomycin, kanamycin, paromomycin, tobramycin, apramycin, streptomycin, dihydrostreptomycin, amikacin, netilmicin, sisomicin and gentamicins. All eleven antibiotics yielded positive ion spectra. These hydrophilic antibiotics were derivitized to extractable chromopheric compounds. All but two antibiotics (streptomycin and dihydrostreptomycin) yielded nitrophenyl derivatives and spectra were obtained in both negative and positive ion modes. Derivatized aminoglycosides produced cation and anion spectra with quasimolecular ions corresponding to [M + H]+., M+, [M - H]-., [M + Na]+, [M + K]+ and M-. or [M - H]- and M-. or [M - H]-. Underivatized antibiotics were best examined in the positive ion mode. 252Cf PD mass spectrometry consistently produced very strong molecular or quasimolecular ions for all aminoglycoside antibiotics.
JF  - Biomedical & environmental mass spectrometry
AU  - Khan, A H
AU  - Shaikh, B
AU  - Allen, E H
AU  - Sokoloski, E A
AD  - Division of Production Drugs, US Food and Drug Administration, Rockville, Maryland 20857.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 329
EP  - 335
VL  - 17
IS  - 4
SN  - 0887-6134, 0887-6134
KW  - Aminoglycosides
KW  - 0
KW  - Anti-Bacterial Agents
KW  - Californium
KW  - 975X05H15A
KW  - Index Medicus
KW  - Drug Residues -- analysis
KW  - Anti-Bacterial Agents -- analysis
KW  - Mass Spectrometry -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-12
N1  - Date created - 1989-01-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Alterations in maternal plasma corticosterone levels following treatment with phenytoin.
AN  - 78528131; 3188023
AB  - The mechanisms of the embryotoxic effects of the anticonvulsant drug, phenytoin (PHT), are unknown. Glucocorticoids and PHT demonstrate similar embryopathic effects and strain sensitivity in that A/J mice are very sensitive to the embryopathic effects of synthetic glucocorticoids and PHT while C57BL/6 (B6) mice are comparatively resistant to both. It is possible that teratogenic consequences of PHT are not a result of drug interaction at the target site but are mediated indirectly by glucocorticoids. In this study, PHT was administered by intraperitoneal injection at 25 (a nonteratogenic dose) or 75 mg/kg body weight (a teratogenic dose) to pregnant A/J mice on Day 10 of gestation. Mice of the B6 strain received the drug at 75 mg/kg on Day 10. Control mice received vehicle (pH 11.0 distilled water). Dams were killed at various times after the injection; plasma samples were obtained, and corticosterone levels were determined by radioimmunoassay. In control animals, maternal plasma corticosterone levels were elevated soon after dosing but gradually declined, except for an apparent circadian rhythm effect seen in samples obtained in the afternoon. Administration of a nonteratogenic dose of PHT to A/J mice caused a temporary increase in plasma corticosterone levels which decreased to the control level between 6 and 24 hr following dosing. Treatment with a teratogenic dose in A/J mice led to plasma levels that remained elevated for the entire 48-hr period examined in this study. In B6 mice, treatment with 75 mg/kg increased plasma corticosterone levels for 24 hr, after which they declined to the control value by 30 hr. The adrenal corticosteroid response of A/J mice to PHT appeared to be much more sensitive than that of B6 mice, and there appeared to be a relationship between plasma levels of PHT and corticosterone. The lengthy increase in plasma corticosterone during organogenesis may be a factor in the increased incidence of cleft lip and palate seen after administration of PHT to A/J mice.
JF  - Toxicology and applied pharmacology
AU  - Hansen, D K
AU  - Holson, R R
AU  - Sullivan, P A
AU  - Grafton, T F
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 24
EP  - 32
VL  - 96
IS  - 1
SN  - 0041-008X, 0041-008X
KW  - Phenytoin
KW  - 6158TKW0C5
KW  - Corticosterone
KW  - W980KJ009P
KW  - Index Medicus
KW  - Mice, Inbred A
KW  - Animals
KW  - Mice, Inbred C57BL
KW  - Mice
KW  - Radioimmunoassay
KW  - Female
KW  - Pregnancy
KW  - Phenytoin -- pharmacology
KW  - Corticosterone -- blood
KW  - Phenytoin -- blood
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-20
N1  - Date created - 1988-12-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Alterations in colonic thymidine kinase enzyme activity induced by consumption of various dietary fibers.
AN  - 78517510; 2847179
AB  - Dietary fibers may tend to enhance or inhibit chemically induced experimental colon cancer, depending on the particular fiber consumed. This study examined the relationship between colonic thymidine kinase enzyme activity and mucin histochemistry and the reported effects of various dietary fibers on chemically induced colon carcinogenesis. Fiber-supplemented diets containing fibers reported to inhibit (wheat bran) or enhance (guar gum, carrageenan) chemically induced colon carcinogenesis in the rat were selected. Four groups of male Fischer 344 rats consumed 10% wheat bran, 5% guar gum, 5% carrageenan, or fiber-free diets ad libitum for 4 weeks. At the completion of the treatment period, the distal 12 cm of colonic mucosa was scraped off and homogenized for determination of thymidine kinase activity, and a 0.5-cm section of midcolon was processed by the high-iron diamine/Alcian blue method for mucin histochemistry. Final animal weights did not differ significantly among groups. Thymidine kinase enzyme specific activity (mumole thymidine phosphate formed x 10(6)/min/mg protein, means +/- SEMs) was not significantly different in the fiber-free, wheat bran, and guar gum groups (10.98 +/- 1.50, 7.41 +/- 1.09, and 9.11 +/- 2.04, respectively) but was markedly elevated at 41.84 +/- 4.65 in the carrageenan group (alpha less than 0.001). Mucin histochemistry failed to reveal any significant differences among dietary groups.
JF  - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
AU  - Calvert, R J
AU  - Reicks, M
AD  - Experimental Nutrition Branch, U.S. Food and Drug Administration, Washington D.C. 20204.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 45
EP  - 51
VL  - 189
IS  - 1
SN  - 0037-9727, 0037-9727
KW  - Galactans
KW  - 0
KW  - Mannans
KW  - Mucins
KW  - Plant Gums
KW  - Carrageenan
KW  - 9000-07-1
KW  - guar gum
KW  - E89I1637KE
KW  - Thymidine Kinase
KW  - EC 2.7.1.21
KW  - Index Medicus
KW  - Erythema -- etiology
KW  - Animals
KW  - Erythema -- pathology
KW  - Erythema -- enzymology
KW  - Triticum
KW  - Intestinal Mucosa -- enzymology
KW  - Rats
KW  - Body Weight
KW  - Rats, Inbred F344
KW  - Mucins -- analysis
KW  - Intestinal Mucosa -- pathology
KW  - Male
KW  - Dietary Fiber -- administration & dosage
KW  - Colon -- pathology
KW  - Colon -- enzymology
KW  - Thymidine Kinase -- metabolism
KW  - Dietary Fiber -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-05
N1  - Date created - 1988-12-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Phenytoin-induced stress protein synthesis in mouse embryonic tissue.
AN  - 78515646; 3186762
AB  - Several proteins have been shown to be synthesized in response to various environmental stimuli, including treatment with teratogens. The role of these proteins in the teratogenic process is unknown. Pregnant A/J mice were treated with either a teratogenic or a non-teratogenic dose of the anticonvulsant drug, phenytoin (PHT). Protein synthesis in embryonic craniofacial (target) tissue or forelimb buds (non-target) was determined by incorporation of radiolabeled leucine and analysis by two-dimensional polyacrylamide gel electrophoresis. Synthesis of three proteins in target tissue and one protein in non-target tissue was stimulated by drug treatment. These results suggest that synthesis of specific stress proteins may serve as biomarkers of drug-target tissue interaction.
JF  - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
AU  - Hansen, D K
AU  - Anson, J F
AU  - Hinson, W G
AU  - Pipkin, J L
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 136
EP  - 140
VL  - 189
IS  - 1
SN  - 0037-9727, 0037-9727
KW  - Heat-Shock Proteins
KW  - 0
KW  - Nuclear Proteins
KW  - Teratogens
KW  - Phenytoin
KW  - 6158TKW0C5
KW  - Index Medicus
KW  - Nuclear Proteins -- isolation & purification
KW  - Mice, Inbred A
KW  - Animals
KW  - Skull -- embryology
KW  - Electrophoresis, Polyacrylamide Gel
KW  - Facial Bones -- embryology
KW  - Nuclear Proteins -- biosynthesis
KW  - Teratogens -- toxicity
KW  - Mice
KW  - Forelimb -- embryology
KW  - Female
KW  - Pregnancy
KW  - Phenytoin -- toxicity
KW  - Heat-Shock Proteins -- biosynthesis
KW  - Heat-Shock Proteins -- isolation & purification
KW  - Embryo, Mammalian -- metabolism
KW  - Embryo, Mammalian -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-05
N1  - Date created - 1988-12-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Spontaneous mutagenesis of herpesvirus in human cells depends on cell monolayer density.
AN  - 78497014; 2846504
JF  - In vitro cellular & developmental biology : journal of the Tissue Culture Association
AU  - Lytle, C D
AU  - Carney, P G
AU  - Hitchins, V M
AU  - Olvey, K M
AU  - Bockstahler, L E
AU  - Bushar, H F
AD  - Center for Devices and Radiological Health, FDA, Rockville, Maryland 20857.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 963
EP  - 964
VL  - 24
IS  - 10
SN  - 0883-8364, 0883-8364
KW  - Index Medicus
KW  - Humans
KW  - Simplexvirus -- genetics
KW  - Mutagenicity Tests -- methods
KW  - Cells, Cultured -- microbiology
KW  - Mutation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-14
N1  - Date created - 1988-12-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Effects of short duration exposures to acetone and methyl ethyl ketone.
AN  - 78475669; 3176071
AB  - Workers are commonly exposed to mixtures or combinations of chemical agents, and these mixtures often consist of solvents. One group of solvents that has been extensively studied for its neurotoxic properties has been the ketones. However, previous research has focused on neuropathies produced by extended exposures and not on the simple pharmacokinetics or the reversible central nervous system (CNS) effects from short-duration exposures. In this research, 137 volunteers were recruited and tested for neurobehavioral performance changes and biochemical indicators during and after a short-duration (4-h) exposure to either acetone at 250 ppm, methyl ethyl ketone (MEK) at 200 ppm, acetone at 125 ppm with MEK at 100 ppm, or a chemical-placebo. Ethanol (95%, 0.84 ml/kg) was used as a positive control. Testing took place in an environmental chamber with four test stations. The computer-controlled test regimen took 10 h, and several measures were collected: (1) biochemical measurements of venous blood and alveolar breath; (2) psychomotor tests of choice reaction time, visual vigilance, dual task (auditory tone discrimination and tracking), and memory scanning; (3) one sensorimotor (postural sway) test; and (4) one psychological (Profile of Mood States [POMS]) test. Blood and breath concentrations during and after exposure did not demonstrate any interaction between the two solvents, nor were statistically significant sex differences present during uptake or elimination. The 250-ppm acetone exposure produced small but statistically significant differences from controls in two measures of the auditory tone discrimination task, and on the anger-hostility scale (males only) of the POMS test. The other chemical exposure conditions, MEK at 200 ppm and combination MEK with acetone, produced no consistent statistically significant results, which suggests there was no potentiation of the acetone effects with the co-exposure to MEK or vice versa under these test conditions. Ethanol at 0.07-0.08% blood alcohol concentration (BAC) caused significant decrements on both the auditory tone and tracking tests in the dual task.
JF  - Toxicology letters
AU  - Dick, R B
AU  - Brown, W D
AU  - Setzer, J V
AU  - Taylor, B J
AU  - Shukla, R
AD  - U.S. Department of Health and Human Services, Centers for Disease Control, Cincinnati, OH.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 31
EP  - 49
VL  - 43
IS  - 1-3
SN  - 0378-4274, 0378-4274
KW  - Butanones
KW  - 0
KW  - Acetone
KW  - 1364PS73AF
KW  - methylethyl ketone
KW  - 6PT9KLV9IO
KW  - Index Medicus
KW  - Affect -- drug effects
KW  - Psychomotor Performance -- drug effects
KW  - Memory -- drug effects
KW  - Humans
KW  - Body Burden
KW  - Adult
KW  - Attention -- drug effects
KW  - Adolescent
KW  - Time Factors
KW  - Male
KW  - Female
KW  - Reaction Time
KW  - Postural Balance -- drug effects
KW  - Butanones -- toxicity
KW  - Butanones -- blood
KW  - Environmental Exposure
KW  - Acetone -- blood
KW  - Acetone -- toxicity
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78475669?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Effects+of+short+duration+exposures+to+acetone+and+methyl+ethyl+ketone.&rft.au=Dick%2C+R+B%3BBrown%2C+W+D%3BSetzer%2C+J+V%3BTaylor%2C+B+J%3BShukla%2C+R&rft.aulast=Dick&rft.aufirst=R&rft.date=1988-10-01&rft.volume=43&rft.issue=1-3&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-22
N1  - Date created - 1988-11-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Uterine abnormalities in rats exposed neonatally to diethylstilbestrol, ethynylestradiol, or clomiphene citrate.
AN  - 78473658; 3176028
AB  - The toxicity of the synthetic estrogens diethylstilbestrol (DES), and ethynylestradiol (EE), and the antiestrogen clomiphene citrate (CC) was evaluated by assessing postnatal uterine growth and development prior to the onset of puberty in the rat. Both DES and EE, administered during the neonatal period (postnatal days 1-5), initially increased uterine weight and luminal epithelium hypertrophy. However, uterine weight declined in both DES- and EE-treated animals and fell below controls beyond day 11. Luminal epithelium stimulation generally paralleled uterine weight changes. Precocious development of uterine glands occurred after estrogenization (compared to untreated controls), but subsequently gland numbers were approximately 60% of control levels. Neonatal CC exposure induced only slight uterine weight gain but caused prolonged luminal epithelium hypertrophy and inhibited uterine gland genesis. Luminal epithelium hypertrophy appears to be a useful measure of antiestrogen activity. These data demonstrate the toxicity of DES and EE as assessed by altered prepubertal uterine gland development. Additionally, the inhibition of uterine gland genesis after neonatal CC exposure occurs in conjunction with prolonged luminal epithelium hypertrophy.
JF  - Toxicology
AU  - Branham, W S
AU  - Zehr, D R
AU  - Chen, J J
AU  - Sheehan, D M
AD  - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 201
EP  - 212
VL  - 51
IS  - 2-3
SN  - 0300-483X, 0300-483X
KW  - Clomiphene
KW  - 1HRS458QU2
KW  - Ethinyl Estradiol
KW  - 423D2T571U
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals, Newborn
KW  - Animals
KW  - Hypertrophy -- chemically induced
KW  - Epithelium -- pathology
KW  - Female
KW  - Epithelium -- drug effects
KW  - Organ Size -- drug effects
KW  - Uterus -- growth & development
KW  - Diethylstilbestrol -- toxicity
KW  - Clomiphene -- toxicity
KW  - Ethinyl Estradiol -- toxicity
KW  - Uterus -- pathology
KW  - Uterus -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-14
N1  - Date created - 1988-11-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Investigations of aneuploidy-inducing chemical combinations in Saccharomyces cerevisiae.
AN  - 78459229; 3050491
AB  - For several years we have been investigating combinations of chemicals for their ability to induce aneuploidy. Earlier published results indicated that combinations of certain chemicals showed a potentiation effect while other combinations did not. We have continued to explore this phenomenon and report additional findings in this communication. Combinations of ethyl acetate and methyl ethyl ketone showed a potentiation effect as did 1-methyl-2-pyrrolidinone-nocodazole combinations. Combinations that did not show a potentiation effect were 2-pyrrolidinone-nocodazole and 1-methyl-2-pyrrolidinone-ethyl acetate. We also found that nocodazole, which is a potent inducer of aneuploidy in yeast extract-peptone-dextrose (YEPD) medium but not in synthetic complete (SC) medium, showed a potentiation effect with ethyl acetate in SC medium. This effect in SC medium is similar to that previously reported for nocodazole with ethyl acetate in YEPD medium. When nocodazole was dissolved in 1-methyl-2-pyrrolidinone as a concentrated stock solution, a potentiation effect occurred even at low concentrations of the solvent.
JF  - Mutation research
AU  - Mayer, V W
AU  - Goin, C J
AD  - Division of Toxicology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 413
EP  - 421
VL  - 201
IS  - 2
SN  - 0027-5107, 0027-5107
KW  - Acetates
KW  - 0
KW  - Benzimidazoles
KW  - Butanones
KW  - Drug Combinations
KW  - Pyrrolidinones
KW  - Solvents
KW  - methylethyl ketone
KW  - 6PT9KLV9IO
KW  - ethyl acetate
KW  - 76845O8NMZ
KW  - Nocodazole
KW  - SH1WY3R615
KW  - Index Medicus
KW  - Benzimidazoles -- pharmacology
KW  - Drug Synergism
KW  - Pyrrolidinones -- pharmacology
KW  - Butanones -- pharmacology
KW  - Acetates -- pharmacology
KW  - Aneuploidy -- drug effects
KW  - Solvents -- pharmacology
KW  - Saccharomyces cerevisiae -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-01
N1  - Date created - 1988-11-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Evaluation of azo food dyes for mutagenicity and inhibition of mutagenicity by methods using Salmonella typhimurium.
AN  - 78457899; 3050504
AB  - The mutagenicity of 4 azo dyes (FD&C Yellow No. 5, FD&C Yellow No. 6, FD&C Red No. 40 and amaranth) that are widely used to color food has been evaluated. 4 different methods were used: (1) the standard Ames plate-incorporation assay performed directly on the dyes in the absence of S9 and in the presence of rat- or hamster-liver S9; (2) application of the standard plate assay to ether extracts of aqueous solutions of the dyes; (3) a variant of the standard assay, using hamster liver S9, preincubation, flavin mononucleotide (FMN) and other modifications designed to facilitate azo reduction; and (4) reduction of the dyes with sodium dithionite, followed by ether extraction and the standard plate assay. Assays that include chemical reduction (methods 3 and 4) were included because azo compounds ingested orally are reduced in the intestine with the release of free aromatic amines. No mutagenic activity was seen for any of the azo dyes tested by using the standard Ames plate assay (method 1). Ether extracts of some samples of FD&C Yellow No. 6, FD&C Red No. 40 and amaranth were active (method 2), but only at high doses, generally 250 mg-equivalents or more per plate. These results indicate the presence of low levels of ether-extractable mutagenic impurities. The FMN preincubation assay (method 3) gave negative results for all dye samples tested. Most batches of FD&C Red No. 40 tested had mutagenic activity that was detectable when the ether extract of less than 1 mg of dithionite-reduced dye was plated in the presence of S9 (method 4). This finding implies that an impurity in these samples of FD&C Red No. 40 can be reduced to yield an ether-extractable mutagen. Dithionite-reduced samples of FD&C Yellow No. 6 and amaranth showed ether-extractable mutagenic activity only at much higher doses than those at which activity was seen with most dithionite-reduced samples of FD&C Red No. 40 (method 4). FD&C Yellow No. 5 showed no mutagenic activity with this method. Mutagenic activity was not detected when FD&C Red No. 40 was tested by using the azo reduction preincubation assay with FMN (method 3).(ABSTRACT TRUNCATED AT 400 WORDS)
JF  - Mutation research
AU  - Prival, M J
AU  - Davis, V M
AU  - Peiperl, M D
AU  - Bell, S J
AD  - Genetic Toxicology Branch, U.S. Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 247
EP  - 259
VL  - 206
IS  - 2
SN  - 0027-5107, 0027-5107
KW  - Azo Compounds
KW  - 0
KW  - Food Coloring Agents
KW  - Mutagens
KW  - Index Medicus
KW  - Molecular Structure
KW  - Mutagenicity Tests -- methods
KW  - Dose-Response Relationship, Drug
KW  - Salmonella typhimurium -- drug effects
KW  - Food Coloring Agents -- pharmacology
KW  - Azo Compounds -- pharmacology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Evaluation+of+azo+food+dyes+for+mutagenicity+and+inhibition+of+mutagenicity+by+methods+using+Salmonella+typhimurium.&rft.au=Prival%2C+M+J%3BDavis%2C+V+M%3BPeiperl%2C+M+D%3BBell%2C+S+J&rft.aulast=Prival&rft.aufirst=M&rft.date=1988-10-01&rft.volume=206&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-18
N1  - Date created - 1988-11-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite.
AN  - 78437266; 3168165
AB  - 6-Nitrochrysene (NC) is a potent lung and liver carcinogen when administered in multiple doses to preweanling mice. We have investigated both the in vitro metabolism of [3H]NC by 9000 g supernatants (S9) prepared from the livers of preweanling mice and the in vivo metabolism of [3H]NC in these animals. The in vitro covalent binding of primary metabolites of NC to DNA after further reductive and/or oxidative metabolism was then examined in an attempt to define the metabolic activation pathway responsible for the formation of carcinogen--DNA adducts in NC-treated preweanling mice. NC-1,2-dihydrodiol, NC-9,10-dihydrodiol, 6-aminochrysene (AC), and several unidentified compounds were found in ethyl acetate extracts of incubations containing [3H]NC and liver S9 from 1- or 8-day-old BLU:Ha mice. Comparison of the in vivo metabolism of NC in 1-day-old animals and 8-day-old animals which had been treated with NC on day 1 indicated that the formation of AC and the two NC dihydrodiols was greater in the younger animals. Further metabolism of NC-1,2-dihydrodiol by S9 from 8-day-old mice yielded AC-1,2-dihydrodiol as a major product. Incubation of AC-1,2-dihydrodiol, calf thymus DNA and liver microsomes from 3-methylcholanthrene-induced rats yielded a single major adduct that was chromatographically and chemically identical to the major adduct formed in [3H]NC- and [3H]-AC-treated preweanling mice. The results indicated that the major DNA adduct found in vivo is derived from the further metabolism of the proximate carcinogen AC-1,2-dihydrodiol.
JF  - Carcinogenesis
AU  - Delclos, K B
AU  - el-Bayoumy, K
AU  - Hecht, S S
AU  - Walker, R P
AU  - Kadlubar, F F
AD  - National Center for Toxicological Research, Division of Biochemical Toxicology, Jefferson, AR 72079.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 1875
EP  - 1884
VL  - 9
IS  - 10
SN  - 0143-3334, 0143-3334
KW  - Carcinogens
KW  - 0
KW  - Chrysenes
KW  - Phenanthrenes
KW  - Tritium
KW  - 10028-17-8
KW  - 6-aminochrysene-1,2-dihydrodiol
KW  - 117760-93-7
KW  - 6-nitrochrysene
KW  - 82ZK83O33Y
KW  - DNA
KW  - 9007-49-2
KW  - Index Medicus
KW  - Molecular Structure
KW  - Mass Spectrometry
KW  - Animals
KW  - Mice, Inbred ICR
KW  - Biotransformation
KW  - Kinetics
KW  - DNA -- metabolism
KW  - Mice
KW  - Magnetic Resonance Spectroscopy
KW  - Phenanthrenes -- metabolism
KW  - Carcinogens -- metabolism
KW  - Microsomes, Liver -- metabolism
KW  - Chrysenes -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-08
N1  - Date created - 1988-11-08
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Occupational skin diseases, United States. Results from the Bureau of Labor Statistics Annual Survey of Occupational Injuries and Illnesses, 1973 through 1984.
AN  - 78427919; 2971337
AB  - The overall incidence rates, numbers, and proportions of occupational skin diseases recorded in the Bureau of Labor Statistics Annual Survey of Occupational Injuries and Illnesses, from 1973 through 1984, were reviewed, and a detailed analysis of occupational skin diseases recorded in the 1984 Annual Survey was performed. Overall incidence rates and numbers of cases declined from 1973 through 1983, but increased slightly in 1984. The major industrial divisions of agriculture and manufacturing have consistently had the highest rates and numbers of cases, respectively; skin diseases have accounted for almost two thirds of all occupational illnesses within agriculture. In the 1984 Annual Survey, 11 industries were ranked in the "Top 15" for both incidence rates and numbers of cases, at the two-digit Standard Industrial Classification level. At the four-digit level for manufacturing, four industries were also ranked in the "Top 15" for both indexes. This analysis has identified industries toward which research efforts should be directed to characterize those occupational activities or exposures most responsible for these higher risks.
JF  - Archives of dermatology
AU  - Mathias, C G
AU  - Morrison, J H
AD  - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1988/10//
PY  - 1988
DA  - October 1988
SP  - 1519
EP  - 1524
VL  - 124
IS  - 10
SN  - 0003-987X, 0003-987X
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Risk Factors
KW  - Humans
KW  - Agricultural Workers' Diseases -- epidemiology
KW  - United States Occupational Safety and Health Administration
KW  - Absenteeism
KW  - Occupations
KW  - Dermatitis, Occupational -- epidemiology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Occupational+skin+diseases%2C+United+States.+Results+from+the+Bureau+of+Labor+Statistics+Annual+Survey+of+Occupational+Injuries+and+Illnesses%2C+1973+through+1984.&rft.au=Mathias%2C+C+G%3BMorrison%2C+J+H&rft.aulast=Mathias&rft.aufirst=C&rft.date=1988-10-01&rft.volume=124&rft.issue=10&rft.spage=1519&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-26
N1  - Date created - 1988-10-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Prenatal ethylene glycol monomethyl ether (EGME) exposure produces electrocardiographic changes in the rat.
AN  - 78427664; 3420619
AB  - The purpose of the present study was to determine if electrocardiographic (EKG) changes observed in fetuses exposed in utero to ethylene glycol monomethyl ether (EGME) persisted beyond the fetal/neonatal period. Groups of pregnant Sprague-Dawley rats were gavaged on gestation days 7-13 (sperm = day 0) with 0, 50, or 75 mg/kg EGME. Body weight prior to delivery was reduced and gestation was prolonged in EGME-treated dams. EGME treatment reduced the percentage of pregnant dams that delivered, litter size, and pup weight. There were no survivors beyond 3 days of age in the 75 mg/kg EGME group. The number of litters surviving through weaning and weight gain of male and female offspring through 8 weeks of age were reduced in the 50 mg/kg EGME group. In this same group, heart weight was unaffected, but heart/body weight ratios were increased when rats were 8 weeks old. EKGs were obtained from unanesthetized and unrestrained rats at 3 and 6 weeks of age. Prenatal EGME exposure increased the QRS interval in 3- and 6-week-old rats, and increased the T wave in 6-week-old rats. Thirty-six and 54% of 3- and 6-week old litters, respectively, had one or more individuals that were classified as having an intraventricular conduction delay (double R wave and QRS interval of 14 msec or longer). No microscopic heart abnormalities were associated with the observed intraventricular conduction delay.
JF  - Toxicology and applied pharmacology
AU  - Toraason, M
AU  - Breitenstein, M
AD  - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988/09/15/
PY  - 1988
DA  - 1988 Sep 15
SP  - 321
EP  - 327
VL  - 95
IS  - 2
SN  - 0041-008X, 0041-008X
KW  - Ethylene Glycols
KW  - 0
KW  - methyl cellosolve
KW  - EK1L6XWI56
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Heart -- drug effects
KW  - Female
KW  - Pregnancy
KW  - Organ Size -- drug effects
KW  - Ethylene Glycols -- toxicity
KW  - Electrocardiography
KW  - Prenatal Exposure Delayed Effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-27
N1  - Date created - 1988-10-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Pesticide residue findings by the Luke method in domestic and imported foods and animal feeds for fiscal years 1982-1986.
AN  - 78702573; 3235407
AB  - Nearly 20,000 samples of food and feed commodities were analyzed for pesticide residues by the U.S. Food and Drug Administration Los Angeles District Laboratory during the 5-year study period 1981-1986. The resultant data base has been summarized to provide separate residue information for domestic and imported samples. The overall violation rates for domestic and imported samples collected on a surveillance basis were 3.0 and 2.6%, respectively. For domestic and imported samples collected on a compliance basis, the overall violation rates were 19.7 and 17.5%, respectively.
JF  - Journal - Association of Official Analytical Chemists
AU  - Hundley, H K
AU  - Cairns, T
AU  - Luke, M A
AU  - Masumoto, H T
AD  - Food and Drug Administration, Los Angeles District Laboratory, CA 90015.
PY  - 1988
SP  - 875
EP  - 892
VL  - 71
IS  - 5
SN  - 0004-5756, 0004-5756
KW  - Pesticide Residues
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - United States Food and Drug Administration
KW  - Food Analysis
KW  - Animal Feed -- analysis
KW  - Pesticide Residues -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-04-28
N1  - Date created - 1989-04-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Thalidomide update: regulatory aspects.
AN  - 78681252; 3227491
JF  - Teratology
AU  - Kelsey, F O
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 221
EP  - 226
VL  - 38
IS  - 3
SN  - 0040-3709, 0040-3709
KW  - Teratogens
KW  - 0
KW  - Thalidomide
KW  - 4Z8R6ORS6L
KW  - Index Medicus
KW  - AIDS/HIV
KW  - United States
KW  - World Health Organization
KW  - United States Food and Drug Administration
KW  - Humans
KW  - Infant, Newborn
KW  - Female
KW  - Pregnancy
KW  - Abnormalities, Drug-Induced
KW  - Thalidomide -- adverse effects
KW  - Legislation, Drug
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-27
N1  - Date created - 1989-03-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Sister chromatid exchange frequency, cellular replication and relative cloning efficiency in human teratocarcinoma-derived cells.
AN  - 78673142; 3224305
AB  - To determine the relationships between the induction of specific biological responses and exposure to DNA-damaging agents, human teratocarcinoma-derived cells were exposed to either ethyl methanesulfonate or to methyl methanesulfonate, and sister chromatid exchange, cellular proliferation and relative cloning ability measured. SCE increased while cellular proliferation and relative cloning ability each decreased in a concentration-dependent manner. Methyl methanesulfonate was consistently more efficient in inducing biological responses than was ethyl methanesulfonate. When the individual responses were compared, the decrease in cellular proliferation paralleled the reduction in cloning efficiency. A strong correlation was also observed between the reduction in relative cloning ability and sister chromatid exchange frequency. Because these relationships are similar to those previously described in other mammalian cell lines, the observations in our study suggest that the P3 cell line is an appropriate choice for modeling effects of toxicant exposure in human cells.
JF  - Cell biology and toxicology
AU  - Morris, S M
AU  - Domon, O E
AU  - Kodell, R L
AU  - McGarrity, L J
AU  - Stegall, D R
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 281
EP  - 294
VL  - 4
IS  - 3
SN  - 0742-2091, 0742-2091
KW  - Ethyl Methanesulfonate
KW  - 9H154DI0UP
KW  - Methyl Methanesulfonate
KW  - AT5C31J09G
KW  - Index Medicus
KW  - Ethyl Methanesulfonate -- pharmacology
KW  - Humans
KW  - Cell Line
KW  - Methyl Methanesulfonate -- pharmacology
KW  - Clone Cells -- drug effects
KW  - Mutagenicity Tests
KW  - Cell Survival -- drug effects
KW  - Sister Chromatid Exchange -- drug effects
KW  - Cell Division -- drug effects
KW  - Teratoma
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-30
N1  - Date created - 1989-03-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Alterations in developing rat uterine cell populations after neonatal exposure to estrogens and antiestrogens.
AN  - 78671997; 3227494
AB  - Exposure of rats to either estrogens or antiestrogens during early postnatal development reduces subsequent uterine growth as measured by uterine weight. However, individual uterine cell types respond differently to these agents and uterine weight alone cannot discern subtle or even large alterations in individual cell populations. Using a computerized planimetric technique, we estimated the prepubertal growth of the uterine luminal epithelium, endometrial stroma, glands, and circular and longitudinal muscle after exposure of neonatal rats (postnatal days 1-5) to the estrogens 17 beta-estradiol (E2), diethylstilbestrol (DES), or ethynylestradiol (EE), and the antiestrogens tamoxifen or clomiphene citrate. On postnatal day 26, the cross-sectional areas of the luminal epithelium, endometrial stroma, and circular muscle were reduced after estrogen exposure, compared to untreated controls, while longitudinal muscle cross-sectional area was not affected. Since cell densities (cell number/unit area) were increased, these estrogen-induced area reductions demonstrate a decrease in cell size. Total cell numbers, estimated as the product of cell type areas and their respective cell densities, were also reduced by neonatal estrogen exposure. The synthetic estrogens DES and EE were more potent than E2 with respect to reduction of uterine growth. Neonatal antiestrogen exposure caused large area reductions only in the uterine glands and luminal epithelium. Little change in cell density occurred in any cell population exposed to antiestrogen. These data demonstrate that the decreased uterine growth resulting from estrogen exposure during early postnatal development is a consequence of combined hypotrophy and hypoplasia in all cell types except longitudinal muscle while antiestrogen-induced morphological alterations were limited to hypoplasia having epithelial cell specificity.
JF  - Teratology
AU  - Branham, W S
AU  - Zehr, D R
AU  - Chen, J J
AU  - Sheehan, D M
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 271
EP  - 279
VL  - 38
IS  - 3
SN  - 0040-3709, 0040-3709
KW  - Tamoxifen
KW  - 094ZI81Y45
KW  - Clomiphene
KW  - 1HRS458QU2
KW  - Ethinyl Estradiol
KW  - 423D2T571U
KW  - Estradiol
KW  - 4TI98Z838E
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals, Newborn
KW  - Animals
KW  - Reference Values
KW  - Muscle Development
KW  - Muscle, Smooth -- growth & development
KW  - Endometrium -- drug effects
KW  - Aging
KW  - Endometrium -- growth & development
KW  - Muscle, Smooth -- drug effects
KW  - Female
KW  - Uterus -- growth & development
KW  - Tamoxifen -- toxicity
KW  - Diethylstilbestrol -- toxicity
KW  - Clomiphene -- toxicity
KW  - Estradiol -- toxicity
KW  - Ethinyl Estradiol -- toxicity
KW  - Uterus -- pathology
KW  - Uterus -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-27
N1  - Date created - 1989-03-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Enumeration of virulent Yersinia enterocolitica colonies by DNA colony hybridization using alkaline treatment and paper filters.
AN  - 78654930; 3221883
AB  - The efficiency of enumerating virulent Yersinia enterocolitica colonies was determined for 10 artificially contaminated foods by autoradiography after DNA colony hybridization using a 32P-labelled genetic probe and paper filters. Enumeration efficiency, which ranged from 0-98% (average 25 +/- 31% standard deviation), improved (42-138%, average 83 +/- 27% standard deviation) after enrichment with 0.5% KOH-0.5% NaCl. These efficiencies are equivalent to those obtained with nitrocellulose filters.
JF  - Molecular and cellular probes
AU  - Jagow, J A
AU  - Hill, W E
AD  - Center for Microbiological Investigations, Food and Drug Administration, Minneapolis, MN 55401.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 189
EP  - 195
VL  - 2
IS  - 3
SN  - 0890-8508, 0890-8508
KW  - DNA, Bacterial
KW  - 0
KW  - Phosphorus Radioisotopes
KW  - Index Medicus
KW  - Paper
KW  - Food Microbiology
KW  - Hydrogen-Ion Concentration
KW  - Nucleic Acid Hybridization
KW  - Autoradiography -- methods
KW  - DNA, Bacterial -- genetics
KW  - Yersinia enterocolitica -- genetics
KW  - Yersinia enterocolitica -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-22
N1  - Date created - 1989-03-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Volatile halocarbons in butter: elevated tetrachloroethylene levels in samples obtained in close proximity to dry-cleaning establishments.
AN  - 78642189; 3219441
JF  - Bulletin of environmental contamination and toxicology
AU  - Miller, L J
AU  - Uhler, A D
AD  - Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 469
EP  - 474
VL  - 41
IS  - 3
SN  - 0007-4861, 0007-4861
KW  - Hydrocarbons
KW  - 0
KW  - Butter
KW  - 8029-34-3
KW  - Tetrachloroethylene
KW  - TJ904HH8SN
KW  - Index Medicus
KW  - District of Columbia
KW  - Laundering
KW  - Hydrocarbons -- analysis
KW  - Butter -- analysis
KW  - Food Contamination -- analysis
KW  - Tetrachloroethylene -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-16
N1  - Date created - 1989-03-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Quantitative analysis of particulate burden in lung tissue.
AN  - 78574001; 3059480
AB  - Numerous methods have been used in the preparation and analysis of the particulate matter deposited in human lungs. Preparation techniques include those for particle isolation and for in situ analysis. Analytical techniques include bulk and particle-by-particle analysis. In this paper, a general discussion of many of these methods is presented along with examples of how two specific techniques have been used. In one study, individual particles from the lungs of 75 randomly selected autopsy cases were analyzed using an automated scanning electron microscopy (SEM)/energy dispersive X-ray microanalysis (EDX) system. An average of 613 million particles, of exogenous origin, per gram of dry lung tissue were found, the major classes of particles being silica, talc, aluminum silicates, and rutile. In the second study, lungs from 50 randomly selected autopsy cases were analyzed using gravimetric and X-ray diffraction (XRD) analysis. The median total particulate material was 0.33 grams, for cases in which samples were prepared by high temperature ashing, and 0.41 grams, for those in which nitric acid digestion was used. The median amount of quartz for all cases, was 0.044 grams. Samples of eighteen of the 75 lungs previously analyzed by automated SEM/EDX were also analyzed using gravimetric and XRD analysis. A good correlation was seen between the results of the two procedures (r = 0.91 for number of exogenous particles versus grams of particulate matter and r = 0.97 for number of silica particles versus amount of quartz).
JF  - Scanning microscopy
AU  - Mastin, J P
AU  - Stettler, L E
AU  - Shelburne, J D
AD  - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 1613
EP  - 1629
VL  - 2
IS  - 3
SN  - 0891-7035, 0891-7035
KW  - Air Pollutants
KW  - 0
KW  - Index Medicus
KW  - X-Ray Diffraction
KW  - Humans
KW  - Body Burden
KW  - Microscopy, Electron, Scanning
KW  - Lung -- analysis
KW  - Lung -- ultrastructure
KW  - Air Pollutants -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-19
N1  - Date created - 1989-01-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Oral contraceptives and premenopausal breast cancer in nulliparous women.
AN  - 78446126; 3168449
AB  - Characteristics of women with potential for modifying the relationship between use of oral contraceptives (OCs) and the risk of premenopausal breast cancer were investigated using data from the Cancer and Steroid Hormone study, a population-based, case-control study conducted in eight geographic areas of the United States. Cases consisted of 2945 women who were premenopausal and 20-54 years of age when breast cancer was diagnosed between December 1, 1980, and December 31, 1982; controls consisted of 2646 women with no history of breast cancer who were also premenopausal and 20-54 years of age when selected during the same period. Results are presented with the cases and controls divided into eight groups on the basis of age at diagnosis on selection (20-44, 45-54), parity (0, greater than or equal to 1), and age at menarche (less than 13, greater than or equal to 13). Among nulliparous women who experienced menarche before age 13, the relative risk of developing breast cancer in the age interval 20-44 years is estimated to be 1.0 for never-users of OCs (reference), 1.3 for greater than 0-3 years of use (95% confidence intervals 0.7-2.4), 1.3 for 4-7 years (95% CI 0.7-2.6), 2.7 for 8-11 years (95% CI 1.2-6.3), and 11.8 for 12 years or longer (95% CI 1.4-95.7). OC use is not significantly related to the risk of breast cancer among women in any of the other seven groups. These findings suggest that prolonged OC use may accelerate the onset of breast cancer for a small group of susceptible women while having no appreciable impact on overall risk. The findings should be regarded as tentative, however, since they are based upon numerous comparisons and because age of menarche was stratified at 13 years to highlight the concentration of breast cancer risk apparent in our data.
JF  - Contraception
AU  - Stadel, B V
AU  - Lai, S H
AU  - Schlesselman, J J
AU  - Murray, P
AD  - Epidemiology Branch, Food and Drug Administration, Rockville, Maryland 20857.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 287
EP  - 299
VL  - 38
IS  - 3
SN  - 0010-7824, 0010-7824
KW  - Contraceptives, Oral
KW  - 0
KW  - Index Medicus
KW  - Population
KW  - Fertility
KW  - Research Methodology
KW  - Population Dynamics
KW  - Breast Cancer
KW  - Oral Contraceptives
KW  - Contraceptive Methods
KW  - High Risk Women
KW  - Population Characteristics
KW  - Menarche
KW  - Demographic Factors
KW  - Diseases
KW  - Family Planning
KW  - Data Analysis
KW  - Time Factors
KW  - Parity
KW  - Longterm Effects
KW  - Cancer
KW  - Neoplasms
KW  - Control Groups
KW  - Contraception
KW  - Nulliparity
KW  - Risk Factors
KW  - Reproduction
KW  - Menstruation
KW  - Fertility Measurements
KW  - Biology
KW  - Age Factors
KW  - Humans
KW  - Adult
KW  - Middle Aged
KW  - Female
KW  - Pregnancy
KW  - Contraceptives, Oral -- adverse effects
KW  - Breast Neoplasms -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-22
N1  - Date created - 1988-11-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Mechanism of formation and structural characterization of DNA adducts derived from peroxidative activation of benzidine.
AN  - 78383133; 3136947
AB  - Although the peroxidative metabolism of benzidine and other carcinogenic arylamines has been regarded as a significant pathway in extrahepatic tissues, the mechanism of peroxidase-mediated covalent binding to DNA has remained unclear. In this study, we have compared the metabolic activation of benzidine by prostaglandin H synthase, horseradish peroxidase, chloroperoxidase, and lactoperoxidase. All four peroxidases mediated the binding of benzidine to DNA and equimolar amounts of hydrogen peroxide (or arachidonic acid) and benzidine were required for the maximal binding in the system with either horseradish peroxidase or prostaglandin H synthase. In reactions containing both synthetic [3H]benzidine diimine and [14C]benzidine, rapid equilibration of both compounds was evident through the formation of its charge-transfer complex and the 14C-associated binding to DNA. However, the total binding (3H and 14C) correlated with the concentration of benzidine diimine rather than that of the charge-transfer complex. Two major and one minor deoxyguanosine adducts (P-I, P-III and P-IV, respectively) were isolated after the enzymatic hydrolysis of the benzidine-modified DNA. P-I was identified as N-(deoxyguanosin-8-yl)-benzidine, which was the major adduct formed by reaction of benzidine diimine with DNA. P-IV, which was also formed on reaction of benzidine diimine with DNA, was consistent with an N-(deoxyguanosin-N2-yl)-benzidine structure. P-III, which was formed only in the peroxidase incubations with DNA, was characterized as a novel N,3-(deoxyguanosin-N7,C8-yl)-benzidine derivative. Furthermore, this DNA adduct was shown to arise by the action of the peroxidase on DNA that had been previously modified by benzidine diimine. These results indicate that the two-electron oxidation product of benzidine, benzidine diimine, is the predominant reactive intermediate for the DNA binding mediated by peroxidases.
JF  - Carcinogenesis
AU  - Yamazoe, Y
AU  - Zenser, T V
AU  - Miller, D W
AU  - Kadlubar, F F
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 1635
EP  - 1641
VL  - 9
IS  - 9
SN  - 0143-3334, 0143-3334
KW  - Arachidonic Acids
KW  - 0
KW  - Benzidines
KW  - Arachidonic Acid
KW  - 27YG812J1I
KW  - benzidine
KW  - 2X02101HVF
KW  - Peroxidases
KW  - EC 1.11.1.-
KW  - Index Medicus
KW  - Oxidation-Reduction
KW  - Hydrogen-Ion Concentration
KW  - In Vitro Techniques
KW  - Spectrophotometry, Ultraviolet
KW  - DNA Damage
KW  - Peroxidases -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-06
N1  - Date created - 1988-10-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Compliance with OSHA record-keeping requirements.
AN  - 78371535; 3407825
AB  - The Occupational Safety and Health Act of 1970 requires employers to maintain records of workplace injuries and illnesses. To assess compliance with the law, data from the National Occupational Exposure Survey (NOES) were examined. Of the 4,185 companies with 11 or more employees, 75 per cent maintained OSHA Form 200 designed for recording illnesses and injuries. The number of employees and the presence of a union were positive determinants in the record maintenance. Of companies with 500 or more employees, 95 per cent kept records compared with 60 per cent of companies with between 11 and 99 employees.
JF  - American journal of public health
AU  - Seligman, P J
AU  - Sieber, W K
AU  - Pedersen, D H
AU  - Sundin, D S
AU  - Frazier, T M
AD  - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 1218
EP  - 1219
VL  - 78
IS  - 9
SN  - 0090-0036, 0090-0036
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Wounds and Injuries -- epidemiology
KW  - Humans
KW  - Forms and Records Control
KW  - Accidents, Occupational
KW  - Documentation
KW  - Records as Topic -- standards
KW  - United States Occupational Safety and Health Administration
KW  - Occupational Diseases -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-15
N1  - Date created - 1988-09-15
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Am J Public Health. 1988 Sep;78(9):1215-7 [3407824]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Fatal occupational injuries in US industries, 1984: comparison of two national surveillance systems.
AN  - 78367564; 3407824
AB  - This paper compares the results of analyses of 1984 fatalities as identified in the National Institute for Occupational Safety and Health (NIOSH) National Traumatic Occupational Fatality (NTOF) data base with those of the Bureau of Labor Statistics' Annual Survey of Occupational Injuries and Illnesses (AS) for 1984. The fatality rates for industries were similar in both analyses; however, differences in number of injuries suggest underrepresentation in the AS of fatal injuries in several, high-risk industries. Differences and similarities in methods and results between the two national surveillance systems are described and their application to research and injury prevention are discussed.
JF  - American journal of public health
AU  - Stout-Wiegand, N
AD  - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505.
Y1  - 1988/09//
PY  - 1988
DA  - September 1988
SP  - 1215
EP  - 1217
VL  - 78
IS  - 9
SN  - 0090-0036, 0090-0036
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Death Certificates
KW  - Population Surveillance
KW  - Industry
KW  - Accidents, Occupational
KW  - Wounds and Injuries -- mortality
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-15
N1  - Date created - 1988-09-15
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Am J Public Health. 1988 Sep;78(9):1218-9 [3407825]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Behaviorally conditioned suppression of murine T-cell dependent but not T-cell independent antibody responses.
AN  - 78681355; 3265791
AB  - The aversive and immunosuppressive effects of cyclophosphamide (CY, 250 mg/kg IP), an unconditioned stimulus (UCS), were paired with the presentation of a novel saccharine flavored drinking solution (SAC), a conditioned stimulus (CS), in female Balb/c mice. The objective was to determine the temporal relationship between presentation of the CS (SAC) and immunization with sheep red blood cell (SRBCs), a T-cell dependent antigen, and type III pneumococcal polysaccharide (S3), a T-cell independent antigen, on subsequent antibody responses. Reexposure to the CS or UCS occurred on days -4, -2, 0, +2, or +4 relative to immunization. Primary antibody responses in each group were measured six days following immunization. A strong association between the CS and the UCS developed, producing flavor aversions as evidenced by decreased SAC consumption. CY administration by itself consistently suppressed both types of antibody responses. CS presentation (i.e., SAC) had no significant effect on anti-S3 antibody response. However, the anti-SRBC response was significantly depressed following CS exposure. Exposure to the CS only on days -4 or +2 relative to immunization resulted in statistically significant suppression of antibody response to SRBC's while exposure on days -2, 0, and +4 resulted in anti-SRBC antibody suppression that did not reach significance. These results support the hypothesis that conditioning of antibody responses is relatively specific for T-cell dependent antigens, and that the timing of CS presentation relative to immunization is important in conditioning a suppression of antibody responses.
JF  - Pharmacology, biochemistry, and behavior
AU  - Schulze, G E
AU  - Benson, R W
AU  - Paule, M G
AU  - Roberts, D W
AD  - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/08//
PY  - 1988
DA  - August 1988
SP  - 859
EP  - 865
VL  - 30
IS  - 4
SN  - 0091-3057, 0091-3057
KW  - Cyclophosphamide
KW  - 8N3DW7272P
KW  - Index Medicus
KW  - Animals
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Avoidance Learning
KW  - Female
KW  - Immunosuppression
KW  - Cyclophosphamide -- pharmacology
KW  - Conditioning (Psychology)
KW  - Immunity, Cellular -- drug effects
KW  - T-Lymphocytes -- immunology
KW  - Antibody Formation -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-04-04
N1  - Date created - 1989-04-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Lung volume reference values for blue collar workers not exposed to occupational respiratory hazards.
AN  - 78455062; 3171719
AB  - Epidemiologic research into occupationally related lung disease often requires the comparison of a study group with an external nonexposed comparison group. In order to develop such an external comparison group, blue collar workers, who had no obvious adverse occupational pulmonary exposure, performed simple spirometry, were administered a standard questionnaire, and had standard posterior-anterior and lateral chest radiographs taken. Prediction equations were established for three indices of lung volume, namely total lung capacity, residual volume, and their ratio, for various combinations of race, sex, and smoking groups. Asymptomatic non-smokers with normal radiograph results were then extracted from the overall group, and separate prediction equations were established. The relationship between age and total lung capacity is discussed.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Petersen, M R
AU  - Hodous, T K
AD  - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505.
Y1  - 1988/08//
PY  - 1988
DA  - August 1988
SP  - 626
EP  - 632
VL  - 30
IS  - 8
SN  - 0096-1736, 0096-1736
KW  - Index Medicus
KW  - Space life sciences
KW  - Smoking
KW  - Reference Values
KW  - Spirometry
KW  - Residual Volume
KW  - Vital Capacity
KW  - Humans
KW  - Adult
KW  - Total Lung Capacity
KW  - Forced Expiratory Volume
KW  - Models, Biological
KW  - Male
KW  - Female
KW  - Occupational Diseases -- physiopathology
KW  - Lung Diseases -- physiopathology
KW  - Lung Volume Measurements
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-21
N1  - Date created - 1988-11-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Ischemic heart disease and acute myocardial infarction mortality among police officers.
AN  - 78449639; 3171723
AB  - The relationship between the occupation of police officer and ischemic heart disease (IHD) mortality was examined through case-control studies using 1968/78 death certificate records from Rhode Island and Utah. IHD was divided into two subcategories--acute myocardial infarction (AMI) and other IHD. In both states, the odds ratio (OR) for AMI was significantly elevated (Rhode Island, OR = 1.3; Utah, OR = 1.8), and was higher than the OR for other IHD (Rhode Island, OR = 1.1; Utah, OR = 1.4). The odds ratio for AMI was higher in the less than 65 yr age group (Rhode Island, OR = 2.1; Utah, OR = 2.1) than in the greater than or equal to 65 yr age group (Rhode Island, OR = 0.9; Utah, OR = 1.6). These results suggest that the elevated risk for IHD among police officers observed in this and other studies is primarily due to an elevated risk for AMI. The pattern of diminishing risk with age suggests a risk factor, possibly stress, the effect of which diminishes when exposure ceases at retirement.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Dubrow, R
AU  - Burnett, C A
AU  - Gute, D M
AU  - Brockert, J E
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH.
Y1  - 1988/08//
PY  - 1988
DA  - August 1988
SP  - 650
EP  - 654
VL  - 30
IS  - 8
SN  - 0096-1736, 0096-1736
KW  - Index Medicus
KW  - Age Factors
KW  - Rhode Island
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Utah
KW  - Male
KW  - Myocardial Infarction -- mortality
KW  - Coronary Disease -- mortality
KW  - Social Control, Formal
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-21
N1  - Date created - 1988-11-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Serum sickness-like reactions to amoxicillin, cefaclor, cephalexin, and trimethoprim-sulfamethoxazole.
AN  - 78361353; 3261315
JF  - The Journal of infectious diseases
AU  - Platt, R
AU  - Dreis, M W
AU  - Kennedy, D L
AU  - Kuritsky, J N
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland.
Y1  - 1988/08//
PY  - 1988
DA  - August 1988
SP  - 474
EP  - 477
VL  - 158
IS  - 2
SN  - 0022-1899, 0022-1899
KW  - Drug Combinations
KW  - 0
KW  - Cefaclor
KW  - 69K7K19H4L
KW  - Amoxicillin
KW  - 804826J2HU
KW  - Trimethoprim, Sulfamethoxazole Drug Combination
KW  - 8064-90-2
KW  - Trimethoprim
KW  - AN164J8Y0X
KW  - Sulfamethoxazole
KW  - JE42381TNV
KW  - Cephalexin
KW  - OBN7UDS42Y
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Humans
KW  - Drug Combinations -- adverse effects
KW  - Serum Sickness -- chemically induced
KW  - Trimethoprim -- adverse effects
KW  - Sulfamethoxazole -- adverse effects
KW  - Cephalexin -- adverse effects
KW  - Cephalexin -- analogs & derivatives
KW  - Amoxicillin -- adverse effects
KW  - Cefaclor -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-15
N1  - Date created - 1988-09-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Commercial blast-freezing of third-stage Anisakis simplex larvae encapsulated in salmon and rockfish.
AN  - 78342003; 3397820
AB  - Sixty-four fish were blast-frozen to -35 C for 15 hr to determine the effects of commercial blast-freezing on the viability of third-stage larvae of Anisakis simplex encapsulated in the muscle and viscera of sockeye salmon (Oncorhynchus nerka) and canary rockfish (Sebastes pinniger). Parallel tests were conducted on larval nematodes in 16 whole (round) salmon, 16 dressed salmon (heads and viscera removed), and 32 whole (round) rockfish. After blast-freezing, 4 in-the-round salmon, 4 dressed salmon, and 8 in-the-round rockfish were examined at 1, 24, 48, and 72 hr. A total of 3,539 dead and 6 live larvae were collected from the fish tissues after standard enzymatic digestion. Salmon were infected with 1,245 of these larvae, and rockfish with 2,300. The 6 live worms, 2 from salmon and 4 from rockfish rounds, were recovered from muscle 1 hr after freezing; they were slightly motile and showed severe internal damage. No viable worms were found at or after 24 hr. The commercial blast-freezing process effectively killed larval nematodes in whole or dressed fish. Market-ready samples of previously blast-frozen silver salmon (O. kisutch) and chum salmon (O. keta) fillets and chum salmon steaks yielded no live worms, thereby confirming the efficacy of this process.
JF  - The Journal of parasitology
AU  - Deardorff, T L
AU  - Throm, R
AD  - Fishery Research Branch, Food and Drug Administration, Dauphin Island, Alabama 36528.
Y1  - 1988/08//
PY  - 1988
DA  - August 1988
SP  - 600
EP  - 603
VL  - 74
IS  - 4
SN  - 0022-3395, 0022-3395
KW  - Index Medicus
KW  - Animals
KW  - Salmon -- parasitology
KW  - Larva
KW  - Humans
KW  - Freezing
KW  - Nematoda -- growth & development
KW  - Food Handling
KW  - Food Contamination
KW  - Nematode Infections -- prevention & control
KW  - Fishes -- parasitology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-08
N1  - Date created - 1988-09-08
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Untargeted viral mutagenesis is not found in X-irradiated monkey cells.
AN  - 78606620; 2850445
AB  - The existence of untargeted viral mutagenesis in X-irradiated cells was investigated in a mammalian virus/cell system, where a low level of such viral mutagenesis can be demonstrated in UV-irradiated cells. In the positive control experiment UV-elicited mutagenesis was shown with cell exposures of 5, 10 and 15 J/m2 and a delay of 24 h between cell irradiation and infection with unirradiated herpes simplex virus. Although X-ray doses of 1, 3 and 10 Gy elicit enhanced reactivation of UV-irradiated virus, no untargeted mutagenesis for any X-ray dose at post-irradiation infection times of 0, 24 or 72 h was observed in this study. Thus untargeted mutagenesis of herpes simplex virus was not demonstrated in X-irradiated monkey cells, under conditions where X-ray-enhanced reactivation occurs and where untargeted mutagenesis in UV-irradiated cells occurs.
JF  - Mutagenesis
AU  - Lytle, C D
AU  - Carney, P G
AU  - Lee, W
AU  - Bushar, H F
AD  - Office of Science and Technology, Center for Devices and Radiological Health, FDA, Rockville, MD 20857.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 297
EP  - 298
VL  - 3
IS  - 4
SN  - 0267-8357, 0267-8357
KW  - Index Medicus
KW  - Animals
KW  - X-Rays
KW  - Ultraviolet Rays
KW  - Cercopithecus aethiops
KW  - Kidney
KW  - Dose-Response Relationship, Radiation
KW  - Cell Line
KW  - Simplexvirus -- genetics
KW  - Mutation
KW  - Cell Transformation, Viral -- radiation effects
KW  - Simplexvirus -- radiation effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-02-22
N1  - Date created - 1989-02-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Allergic contact dermatitis from triglycidyl isocyanurate in polyester paint pigments.
AN  - 78492333; 2972516
JF  - Contact dermatitis
AU  - Mathias, C G
AD  - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 67
EP  - 68
VL  - 19
IS  - 1
SN  - 0105-1873, 0105-1873
KW  - Triazines
KW  - 0
KW  - teroxirone
KW  - 456V4159SL
KW  - Index Medicus
KW  - Humans
KW  - Adult
KW  - Patch Tests
KW  - Male
KW  - Dermatitis, Occupational -- etiology
KW  - Dermatitis, Contact -- prevention & control
KW  - Dermatitis, Occupational -- prevention & control
KW  - Dermatitis, Contact -- etiology
KW  - Triazines -- adverse effects
KW  - Paint -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contact+dermatitis&rft.atitle=Allergic+contact+dermatitis+from+triglycidyl+isocyanurate+in+polyester+paint+pigments.&rft.au=Mathias%2C+C+G&rft.aulast=Mathias&rft.aufirst=C&rft.date=1988-07-01&rft.volume=19&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Contact+dermatitis&rft.issn=01051873&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-21
N1  - Date created - 1988-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Postnatal uterine development in the rat: estrogen and antiestrogen effects on luminal epithelium.
AN  - 78465391; 3051492
AB  - We examined the effects of the synthetic estrogens, diethylstilbestrol (DES) and ethynylestradiol (EE), and the triphenylethylene antiestrogen, clomiphene citrate (CC), on uterine growth and development in the rat. These compounds, unlike estradiol, do not bind significantly to rat serum alphafetoprotein (AFP). Administration of DES or EE during the period of normal uterine gland genesis (postnatal days 10-14) induced luminal epithelium hypertrophy and increased uterine wet weight. The durations of these responses were dose-related. By day 26, luminal epithelium cell numbers were significantly depressed, compared to controls. Uterine gland development was delayed 6 to 9 days, depending upon estrogen dose, and the numbers of uterine glands ultimately achieved were generally less than in untreated control animals. While a daily dose of 0.1 micrograms CC/rat did not alter uterine development, 10 micrograms CC/rat caused prolonged luminal epithelium hypertrophy and inhibited uterine gland genesis without inducing the large increases in uterine weight or the decreases in luminal epithelium cell number seen after estrogen exposure. The number of stromal cells was significantly increased on day 26 after CC exposure. Together with previous studies, these data demonstrate the greater potency and developmental stage specificity of non-AFP-bound estrogens with respect to altering uterine gland development. In addition, these data suggest that the disruptive influence of antiestrogens on gland genesis may be mediated through an indirect influence on the uterine stroma.
JF  - Teratology
AU  - Branham, W S
AU  - Zehr, D R
AU  - Chen, J J
AU  - Sheehan, D M
AD  - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 29
EP  - 36
VL  - 38
IS  - 1
SN  - 0040-3709, 0040-3709
KW  - Clomiphene
KW  - 1HRS458QU2
KW  - Ethinyl Estradiol
KW  - 423D2T571U
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Histological Techniques
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Hypertrophy -- chemically induced
KW  - Female
KW  - Organ Size -- drug effects
KW  - Clomiphene -- pharmacology
KW  - Endometrium -- drug effects
KW  - Diethylstilbestrol -- pharmacology
KW  - Endometrium -- pathology
KW  - Endometrium -- growth & development
KW  - Ethinyl Estradiol -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-14
N1  - Date created - 1988-11-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Review of the decontamination of aflatoxins by ammoniation: current status and regulation.
AN  - 78423384; 3047098
AB  - Ammoniation of corn, peanuts, cottonseed, and meals to alter the toxic and carcinogenic effects of aflatoxin contamination has been the subject of intense research effort by scientists in various government agencies and universities, both in the United States and abroad. Results of these studies have been well documented over the last 20 years. Engineers have devised workable systems of treatment of whole seeds, kernels, or meals; chemists have identified and characterized products formed from the reaction of aflatoxin B1 with ammonia with and without a meal matrix; biochemists have studied the biological effects of these compounds in model systems; and nutritionists have studied animal responses to rations containing ammoniated or non-ammoniated components. This review describes these studies. Results demonstrate overwhelming support for the efficacy and safety of ammoniation as a practical solution to aflatoxin detoxification in animal feeds.
JF  - Journal - Association of Official Analytical Chemists
AU  - Park, D L
AU  - Lee, L S
AU  - Price, R L
AU  - Pohland, A E
AD  - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204.
PY  - 1988
SP  - 685
EP  - 703
VL  - 71
IS  - 4
SN  - 0004-5756, 0004-5756
KW  - Aflatoxins
KW  - 0
KW  - Quaternary Ammonium Compounds
KW  - Index Medicus
KW  - United States
KW  - Food Microbiology
KW  - Legislation as Topic
KW  - Aflatoxins -- analysis
KW  - Food Contamination -- prevention & control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-26
N1  - Date created - 1988-10-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Rapid determination of fumigant and industrial chemical residues in food.
AN  - 78418639; 3417594
AB  - A gas chromatographic (GC) method is described for the determination of 22 fumigant and industrial chemical residues in a variety of foods. The fumigants and industrial chemicals determined are methyl bromide, methylene chloride, carbon disulfide, chloroform, 1,1-dichloroethane, ethylene dichloride, methyl chloroform, carbon tetrachloride, methylene bromide, propylene dichloride, 2,3-dichloropropene, trichloroethylene, 1,3-dichloropropylene, 1,1,2-trichloroethane, chloropicrin, ethylene dibromide, tetrachloroethylene, propylene dibromide, 1,1,2,2-tetrachloroethane, p-dichlorobenzene, o-dichlorobenzene, and 1,2-dibromo-3-chloropropane. Except for the latter three, the fumigants are determined at 90 degrees C on 3.6 m 20% loaded OV-101 columns with electron-capture and Hall-electroconductivity detectors. The other 3 compounds (o-dichlorobenzene, p-dichlorobenzene, and 1,2-dibromo-3-chloropropane), which elute beyond 30 min on the above columns, are determined at 90 degrees C on 1.8 m 5% loaded OV-101 columns with the same detectors. The ng/g-level fortifications have an overall mean analyte recovery of 70% and a coefficient of variation of 40%. The variety of foods examined includes both fatty and nonfatty food types (e.g., off-the-shelf cooked and uncooked grain-based items, dairy products, fresh and canned fruits and vegetables, and meats). Samples are extracted and cleaned up according to fat content and food type. Samples containing less than 71% fat are extracted by using an aqueous: nonaqueous shakeout (20% acetone solution under isooctane). Most extracts (isooctanes) are analyzed directly. Extracts from samples containing from 21 to 70% fat (e.g., ground beef, pecans, and corn chips) are cleaned up further on micro-Florisil columns to remove excess fat. A few other samples containing more than 71% fat or oil (e.g., butter, salad dressing, and vegetable oil) are diluted directly in isooctane and, depending on the degree of dilution, can be cleaned up further on micro-Florisil columns. Also, clear beverages (e.g., soda and tea) are extracted directly with isooctane. These extraction and cleanup techniques were tested on 231 different table-ready foods. Three-hundred incurred residues of 10 different fumigants were found in 138 items examined; 93 items had no detectable residues. The main advantage of the method is rapid semiquantitative determination of multiple fumigants from all food types.
JF  - Journal - Association of Official Analytical Chemists
AU  - Daft, J L
AD  - Food and Drug Administration, Kansas City, MO 64106.
PY  - 1988
SP  - 748
EP  - 760
VL  - 71
IS  - 4
SN  - 0004-5756, 0004-5756
KW  - Indicators and Reagents
KW  - 0
KW  - Pesticide Residues
KW  - Solvents
KW  - Index Medicus
KW  - Electric Conductivity
KW  - Chromatography, Gas
KW  - Reference Standards
KW  - Fumigation
KW  - Drug Residues -- analysis
KW  - Food Contamination -- analysis
KW  - Pesticide Residues -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-26
N1  - Date created - 1988-10-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Improved method for partition of organophosphate pesticide residues on a solid phase partition column.
AN  - 78415581; 3417590
AB  - A specially modified form of diatomaceous earth was used to develop a solid phase partition column which, with methylene chloride, is used to extract organophosphate pesticides from an aqueous acetone filtrate. This column has proven to be a direct replacement for the time consuming and labor intensive separatory funnel partition of the Luke procedure. Recoveries from the column are quantitative and reproducible for industrial phosphates and a wide range of polar and nonpolar organophosphate pesticides. The column is reusable and convenient and results in a 35-45% savings in time over separatory funnel partition. Neither sulfate columns nor separatory funnels are required, and no emulsions are formed.
JF  - Journal - Association of Official Analytical Chemists
AU  - Hopper, M L
AD  - Food and Drug Administration, Total Diet Research Center, Kansas City, MO 64106.
PY  - 1988
SP  - 731
EP  - 734
VL  - 71
IS  - 4
SN  - 0004-5756, 0004-5756
KW  - Insecticides
KW  - 0
KW  - Organophosphorus Compounds
KW  - Pesticide Residues
KW  - Solvents
KW  - Index Medicus
KW  - Chromatography, Gas
KW  - Food Contamination -- analysis
KW  - Animal Feed -- analysis
KW  - Pesticide Residues -- analysis
KW  - Insecticides -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-26
N1  - Date created - 1988-10-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Beta-cyclodextrin post-column fluorescence enhancement of aflatoxins for reverse-phase liquid chromatographic determination in corn.
AN  - 78406876; 3138227
AB  - beta-Cyclodextrin enhances the fluorescence of aflatoxins B1 and G1 in aqueous systems. This effect was utilized in developing a unique reverse-phase liquid chromatographic (LC) method for determination of aflatoxins B1, B2, G1, and G2 (B1 detection limit 1 ppb), without preparing derivatives of B1 and G1. The aflatoxins are dissolved in methanol or the mobile phase for injection onto the LC system. Using a mobile phase of methanol-beta-cyclodextrin (1 + 1), the aflatoxins are resolved on a C18 column. Fluorescence of the aflatoxins is enhanced by post-column introduction of an aqueous concentrated beta-cyclodextrin solution. All 4 aflatoxins elute within 10 min in the order G2, G1, B2, B1. Fluorescence responses for B1 and G1 standards were linear over the concentration range 0.5-10 ng, yielding correlation coefficients (r) of 0.9989 and 1.000, respectively. The average peak response ratio for G1:B1 for the mobile phase-enhancement solution described was 0.765 with a coefficient of variation (CV) of 0.98%. CVs were 6.2, 9.0, and 7.5% for multiple assays of aflatoxin B1 in 3 samples of naturally contaminated corn. For samples of corn spiked to a total B1 content of 8.3 ng/g, average B1 recovery was 90% (CV 11.7%).
JF  - Journal - Association of Official Analytical Chemists
AU  - Francis, O J
AU  - Kirschenheuter, G P
AU  - Ware, G M
AU  - Carman, A S
AU  - Kuan, S S
AD  - Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122.
PY  - 1988
SP  - 725
EP  - 728
VL  - 71
IS  - 4
SN  - 0004-5756, 0004-5756
KW  - Aflatoxins
KW  - 0
KW  - Cyclodextrins
KW  - Dextrins
KW  - Solvents
KW  - beta-Cyclodextrins
KW  - Starch
KW  - 9005-25-8
KW  - Aflatoxin B1
KW  - 9N2N2Y55MH
KW  - betadex
KW  - JV039JZZ3A
KW  - Index Medicus
KW  - Models, Molecular
KW  - Chromatography, Liquid
KW  - Molecular Conformation
KW  - Aflatoxins -- analysis
KW  - Food Contamination -- analysis
KW  - Zea mays -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-26
N1  - Date created - 1988-10-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Mouse hepatoblastomas: a histologic, ultrastructural, and immunohistochemical study.
AN  - 78373156; 2457272
AB  - Hepatoblastomas from B6C3F1 and BALB/c mice were examined by light and electron microscopy and by immunohistochemical reactions for alpha-fetoprotein, keratin, and vimentin. Tumors occurred in one group of a chronic bioassay for the interaction of diet, genetic strain, and the carcinogen, 2-acetylaminofluorene. Tumors had several populations (including epithelial and mesenchymal cells) in various stages of differentiation. Neoplastic epithelial cells had features of embryonal hepatocytes, such as sparse cytoplasmic organelles, absence of glycogen, abundant free ribosomes, occasional bile canaliculi, and peroxisome-like dense bodies. Embryonal fibroblast-like cells had pleomorphic and folded nuclei with prominent perinuclear chromatin and dispersed cytoplasmic organelles. Fibroblast-like cells were surrounded by bundles of collagen fibrils. Intermediate or transitional types of cells were seen. No tumor cells were immunoreactive for mouse alpha-fetoprotein (AFP) antibody, unlike those in hepatocellular adenomas or carcinomas. Epithelial and mesenchymal tumor cells contained intermediate filaments throughout the cytoplasm; some of these cells stained for keratin but not for vimentin. These findings suggest that mouse hepatoblastomas are derived from bipotential liver blastema cells and are composed of a mixture of several cell populations.
JF  - Veterinary pathology
AU  - Nonoyama, T
AU  - Fullerton, F
AU  - Reznik, G
AU  - Bucci, T J
AU  - Ward, J M
AD  - Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, AR.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 286
EP  - 296
VL  - 25
IS  - 4
SN  - 0300-9858, 0300-9858
KW  - Vimentin
KW  - 0
KW  - alpha-Fetoproteins
KW  - Keratins
KW  - 68238-35-7
KW  - Index Medicus
KW  - Vimentin -- analysis
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Microscopy, Electron
KW  - Mice
KW  - Keratins -- analysis
KW  - Mice, Inbred BALB C
KW  - Immunohistochemistry
KW  - alpha-Fetoproteins -- analysis
KW  - Liver Neoplasms -- veterinary
KW  - Liver Neoplasms -- analysis
KW  - Liver Neoplasms, Experimental -- analysis
KW  - Rodent Diseases -- metabolism
KW  - Liver Neoplasms -- ultrastructure
KW  - Liver Neoplasms, Experimental -- ultrastructure
KW  - Liver Neoplasms, Experimental -- veterinary
KW  - Rodent Diseases -- pathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-21
N1  - Date created - 1988-09-21
N1  - Date revised - 2017-02-15
N1  - Last updated - 2017-02-15
ER  - 



TY  - JOUR
T1  - Toxic agent and radiation control: progress toward objectives for the nation for the year 1990.
AN  - 78367058; 3136492
AB  - In 1980, the Department of Health and Human Services set national prevention objectives for 1990 in 15 health priority areas, 1 of which is the control of toxic agents and radiation. Ten objectives related to this area are priorities for the national control effort. Progress is reviewed on those priorities within the responsibilities of the Public Health Service. Six key program elements, or types of support activities, are deemed essential to preventing, identifying, and controlling toxic agent and radiation threats. Significant progress has been made toward achieving objectives for which all key program elements have been successfully implemented to provide the requisite know-how, manpower, and tools. Important advances have been made in reducing the blood lead levels of the population, reducing unnecessary exposure to medical X-rays, evaluating the toxicities of chemicals in toxic waste dumps, and improving the scientific and technical information base and its availability for prevention and control efforts. The most important priority for the forseeable future will be to expand our knowledge of potential health risks posed by toxic agents and radiation. Expanded surveillance systems and data bases are essential to determining the extent of the problems in terms of human health effects and for measuring the impact of prevention programs. Emphasis on the activities embodied in the key elements will encourage the expansion of the knowledge base and its effective application to prevention and control problems.
JF  - Public health reports (Washington, D.C. : 1974)
AU  - Rall, D P
AD  - Department of Health and Human Services, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
PY  - 1988
SP  - 342
EP  - 347
VL  - 103
IS  - 4
SN  - 0033-3549, 0033-3549
KW  - Hazardous Waste
KW  - 0
KW  - Radioactive Waste
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Information Systems
KW  - National Library of Medicine (U.S.)
KW  - Humans
KW  - United States Dept. of Health and Human Services
KW  - Public Health Administration
KW  - Organizational Objectives
KW  - Forecasting
KW  - Radiation Monitoring
KW  - Health Priorities
KW  - Health Physics
KW  - Environmental Pollution -- prevention & control
KW  - Public Health
KW  - Environmental Health -- trends
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-12
N1  - Date created - 1988-09-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
JAMA. 1986 Apr 18;255(15):2031-8 [3959286]
Public Health Rep. 1984 Nov-Dec;99(6):532-8 [6444199]
N Engl J Med. 1982 Sep 2;307(10):573-9 [7110203]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats.
AN  - 78351662; 3398863
AB  - The antihistamine methapyrilene hydrochloride has been shown to be a potent hepatocarcinogen in Fischer 344 rats. It has also been evaluated in a number of short-term in vitro genotoxicity assays resulting in conflicting reports. Short-term in vivo assays suggest that it may act as a promoter. We studied its ability to form DNA adducts in the target organ using the highly sensitive 32P-postlabeling technique. Methapyrilene failed to induce formation of DNA adducts in hepatocellular DNA at doses which induced S-phase DNA synthesis. These data suggest that methapyrilene does not induce the carcinogenesis process through a direct genotoxic mechanism.
JF  - Mutation research
AU  - Casciano, D A
AU  - Shaddock, J G
AU  - Talaska, G
AD  - National Center for Toxicological Research, Division of Genetic Toxicology, Jefferson, AR 72079.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 129
EP  - 135
VL  - 208
IS  - 3-4
SN  - 0027-5107, 0027-5107
KW  - Aminopyridines
KW  - 0
KW  - Carcinogens
KW  - DNA
KW  - 9007-49-2
KW  - Methapyrilene
KW  - A01LX40298
KW  - Index Medicus
KW  - Rats
KW  - Liver Regeneration -- drug effects
KW  - Animals
KW  - Rats, Inbred F344
KW  - DNA Repair
KW  - Liver -- drug effects
KW  - Interphase
KW  - DNA Replication
KW  - Methapyrilene -- pharmacology
KW  - DNA Damage
KW  - Aminopyridines -- pharmacology
KW  - DNA -- drug effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+potent+hepatocarcinogen+methapyrilene+does+not+form+DNA+adducts+in+livers+of+Fischer+344+rats.&rft.au=Casciano%2C+D+A%3BShaddock%2C+J+G%3BTalaska%2C+G&rft.aulast=Casciano&rft.aufirst=D&rft.date=1988-07-01&rft.volume=208&rft.issue=3-4&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-30
N1  - Date created - 1988-08-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Residues of volatile halocarbons in margarines.
AN  - 78334325; 3396733
AB  - Findings of residues of volatile halocarbons (VHCs) such as 1,1,1-trichloroethane, trichloroethylene and tetrachloroethylene in margarine are reported. VHCs were determined by a headspace gas chromatographic method with electron capture detection. Identity was confirmed by headspace gas chromatography-mass spectrometry for some of the higher level (100-5000 ppb) residues. A total of 70 stick, soft and diet soft margarines were purchased in the Washington, DC, metropolitan area. In addition, margarines and margarine ingredients were collected from 19 production lines. These products plus the adhesives used in the packaging were examined. Levels of VHCs ranging from 5 to 100 ppb (ng/g) were found in many of the margarines. The highest concentrations of any individual VHC (tetrachloroethylene at 1-5 ppm) were found in margarines obtained from a supermarket located next to a dry cleaner. Possible sources of VHC residues are discussed.
JF  - Food additives and contaminants
AU  - Entz, R C
AU  - Diachenko, G W
AD  - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, DC 20204.
PY  - 1988
SP  - 267
EP  - 276
VL  - 5
IS  - 3
SN  - 0265-203X, 0265-203X
KW  - Hydrocarbons, Chlorinated
KW  - 0
KW  - Margarine
KW  - 8029-82-1
KW  - Index Medicus
KW  - Chromatography, Gas
KW  - Gas Chromatography-Mass Spectrometry
KW  - Food Contamination
KW  - Margarine -- analysis
KW  - Hydrocarbons, Chlorinated -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Residues+of+volatile+halocarbons+in+margarines.&rft.au=Entz%2C+R+C%3BDiachenko%2C+G+W&rft.aulast=Entz&rft.aufirst=R&rft.date=1988-07-01&rft.volume=5&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-07
N1  - Date created - 1988-09-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA).
AN  - 78316599; 2456631
AB  - MDMA is an amphetamine analog prescribed by some health professionals in the field of psychotherapy and used as a recreational drug by the general public. In recent reports, investigators have suggested that MDMA produces acute neurotoxicity when administered by subcutaneous injection. In order to determine if MDMA produces lasting neurochemical alterations after oral administration, groups of six rats (adult male Sprague-Dawley) were dosed by gavage with either 40 or 80 mg/kg of MDMA or saline vehicle once every 12 hr for 4 days. These rats were terminated 2 weeks after the first dose along with an additional group of rats (80 mg/kg) terminated 4 weeks after the first dose. Brain regions including the hippocampus (H), caudate nucleus (CN), hypothalamus (HY), frontal cortex (FC), and brain stem (BS) were analyzed by HPLC with electrochemical detection for concentrations of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and norepinephrine (NE). In the CN, 40 mg/kg MDMA produced no change in DA, DOPAC, or HVA, but a 50-60% decrease in 5-HT and 5-HIAA concentrations was observed at 2 weeks. Similar effects were observed at 80 mg/kg at both 2 weeks and 4 weeks. A temporary decrease was also seen in DA (21%) and in HVA (34%) 2 weeks but not 4 weeks after the 80 mg/kg dose regimen. In the H, MDMA (40 or 80 mg/kg) produced no change in NE, but a 50-60% decrease was seen in 5-HT and 5-HIAA concentrations at 2 weeks. Concentrations of 5-HT and 5-HIAA were significantly decreased in the HY and FC by all MDMA treatments, but DA and DOPAC concentrations were not altered as compared to vehicle controls. BS was least affected by treatment with no change in DA, DOPAC, or 5-HIAA concentrations and only a slight decrease in 5-HT (19-33%) concentrations at 2 weeks but not at 4 weeks. To determine the sensitivity of the nonhuman primate to MDMA, a total of nine rhesus monkeys were dosed with vehicle or 5 or 10 mg/kg MDMA (n = 3) by gastric intubation twice per day for 4 days. One month after MDMA dosing, a dose-related reduction from vehicle control values for 5-HT and 5-HIAA was observed. These results indicate that the monkey may be more sensitive than the rat to the persistent serotonergic neurotoxicity of MDMA.(ABSTRACT TRUNCATED AT 400 WORDS)
JF  - Toxicology and applied pharmacology
AU  - Slikker, W
AU  - Ali, S F
AU  - Scallet, A C
AU  - Frith, C H
AU  - Newport, G D
AU  - Bailey, J R
AD  - Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 448
EP  - 457
VL  - 94
IS  - 3
SN  - 0041-008X, 0041-008X
KW  - Amphetamines
KW  - 0
KW  - Receptors, Serotonin
KW  - Serotonin
KW  - 333DO1RDJY
KW  - 3,4-Methylenedioxyamphetamine
KW  - 4764-17-4
KW  - Hydroxyindoleacetic Acid
KW  - 54-16-0
KW  - N-Methyl-3,4-methylenedioxyamphetamine
KW  - KE1SEN21RM
KW  - Dopamine
KW  - VTD58H1Z2X
KW  - Index Medicus
KW  - Receptors, Serotonin -- drug effects
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Administration, Oral
KW  - Animals
KW  - Serotonin -- analysis
KW  - Hydroxyindoleacetic Acid -- analysis
KW  - Dopamine -- analysis
KW  - Macaca mulatta
KW  - Species Specificity
KW  - Male
KW  - Female
KW  - Brain Chemistry -- drug effects
KW  - Brain -- pathology
KW  - Brain -- drug effects
KW  - 3,4-Methylenedioxyamphetamine -- analogs & derivatives
KW  - 3,4-Methylenedioxyamphetamine -- toxicity
KW  - Amphetamines -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-02
N1  - Date created - 1988-09-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Comparative carcinogenicity of the food pyrolysis product, 2-amino-5-phenylpyridine, and the known human carcinogen, 4-aminobiphenyl, in the neonatal B6C3F1 mouse.
AN  - 78298632; 3390806
AB  - 2-Amino-5-phenylpyridine (2-APP) is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. Since this mutagen is structurally similar to the multipotent carcinogen, 4-aminobiphenyl (4-ABP), we compared their relative tumorigenic activity in the neonatal male B6C3F1 mouse. After determinations of the maximum tolerated dose (MTD), both aromatic amines were administered i.p. at 2 dose levels (MTD and MTD/2) on days 1, 8, 15 and 22 after birth. Groups were killed at 9 and 12 months and examined for histopathologic changes. No treatment-related neoplastic lesions were observed for 2-APP. In contrast, 4-ABP was strongly carcinogenic and induced a high incidence of multiple hepatocellular adenomas and carcinomas.
JF  - Cancer letters
AU  - Dooley, K L
AU  - Stavenuiter, J F
AU  - Westra, J G
AU  - Kadlubar, F F
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 99
EP  - 103
VL  - 41
IS  - 1
SN  - 0304-3835, 0304-3835
KW  - Aminobiphenyl Compounds
KW  - 0
KW  - Aminopyridines
KW  - Carcinogens
KW  - 4-biphenylamine
KW  - 16054949HJ
KW  - 5-phenyl-2-pyridinamine
KW  - 33421-40-8
KW  - Index Medicus
KW  - Mice, Inbred Strains
KW  - Animals, Newborn
KW  - Animals
KW  - Mice
KW  - Male
KW  - Aminobiphenyl Compounds -- toxicity
KW  - Liver Neoplasms, Experimental -- chemically induced
KW  - Aminopyridines -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-12
N1  - Date created - 1988-08-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Inhibition of 7,12-dimethylbenz[a]anthracene-induced genotoxicity in Chinese hamster ovary cells by retinol and retinoic acid.
AN  - 78266978; 3133130
AB  - The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol nor retinoic acid induced mutants at the HGPRT locus of CHO cells at concentrations ranging from 1 microM to 50 microM without exogenous metabolic activation, and at concentrations ranging from 1 microM to 25 microM in the presence of Aroclor 1254-induced rat liver S9. Retinol and retinoic acid did not affect 100 micrograms/ml ethyl methanesulfonate-induced cytotoxicity or mutations at the HGPRT locus of CHO cells in the absence of exogenous metabolic activation at concentrations ranging from 1 microM to 25 microM. In contrast, retinol and retinoic acid inhibited 7,12-dimethylbenz[a]anthracene-induced cytotoxicity and mutation induction at the HGPRT locus of CHO cells when either uninduced Sprague-Dawley rat liver S9, Aroclor 1254-induced Sprague-Dawley rat liver S9 or co-cultivated primary Sprague-Dawley rat hepatocytes were used to provide metabolic activation. These data show that retinoids are capable of inhibiting mutation induction in mammalian cells in vitro by a chemical promutagen requiring metabolic activation to a reactive form, and suggest that such inhibition is due to an alteration of mutagen metabolism.
JF  - Carcinogenesis
AU  - Budroe, J D
AU  - Schol, H M
AU  - Shaddock, J G
AU  - Casciano, D A
AD  - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 1307
EP  - 1311
VL  - 9
IS  - 7
SN  - 0143-3334, 0143-3334
KW  - Vitamin A
KW  - 11103-57-4
KW  - Tretinoin
KW  - 5688UTC01R
KW  - 9,10-Dimethyl-1,2-benzanthracene
KW  - 57-97-6
KW  - Ethyl Methanesulfonate
KW  - 9H154DI0UP
KW  - Hypoxanthine Phosphoribosyltransferase
KW  - EC 2.4.2.8
KW  - Index Medicus
KW  - Rats
KW  - Mutation -- drug effects
KW  - Ethyl Methanesulfonate -- antagonists & inhibitors
KW  - Animals
KW  - Mutagenicity Tests
KW  - Hypoxanthine Phosphoribosyltransferase -- genetics
KW  - Cell Survival -- drug effects
KW  - Biotransformation
KW  - Microsomes, Liver -- metabolism
KW  - Cell Line
KW  - Cricetinae
KW  - Tretinoin -- pharmacology
KW  - DNA Damage
KW  - Vitamin A -- pharmacology
KW  - 9,10-Dimethyl-1,2-benzanthracene -- antagonists & inhibitors
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-03
N1  - Date created - 1988-08-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The estimated predictive value of screening for illicit drugs in the workplace.
AN  - 78260801; 3381957
AB  - This paper estimates the predictive values of screening tests for six illicit drugs of common concern in the workplace (amphetamines, barbiturates, cocaine, hallucinogens, marijuana, and opiates) using published information on test sensitivity and specificity and survey data on prevalence. Estimated predictive values (negative) were generally high, whereas the estimated predictive value of a positive test ranged from 1 per cent for amphetamines to 100 per cent for hallucinogens and was only 38 per cent for marijuana, the most prevalent drug.
JF  - American journal of public health
AU  - Wells, V E
AU  - Halperin, W
AU  - Thun, M
AD  - Industrywide Studies Branch, NIOSH, Robert A. Taft Laboratories, Cincinnati, OH 45226-1998.
Y1  - 1988/07//
PY  - 1988
DA  - July 1988
SP  - 817
EP  - 819
VL  - 78
IS  - 7
SN  - 0090-0036, 0090-0036
KW  - Street Drugs
KW  - 0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Chromatography, Gas
KW  - Humans
KW  - Adult
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Predictive Value of Tests
KW  - Radioimmunoassay
KW  - Street Drugs -- urine
KW  - Substance-Related Disorders -- epidemiology
KW  - Industry
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=The+estimated+predictive+value+of+screening+for+illicit+drugs+in+the+workplace.&rft.au=Wells%2C+V+E%3BHalperin%2C+W%3BThun%2C+M&rft.aulast=Wells&rft.aufirst=V&rft.date=1988-07-01&rft.volume=78&rft.issue=7&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-21
N1  - Date created - 1988-07-21
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
J Occup Med. 1970 Jan;12(1):6-9 [5410620]
Lancet. 1975 Aug 23;2(7930):357-9 [51154]
Public Health Rep. 1977 Nov-Dec;92(6):554-60 [200968]
J Natl Cancer Inst. 1980 May;64(5):1263-72 [6767876]
J Forensic Sci Soc. 1981 Oct;21(4):327-32 [7031175]
J Occup Med. 1986 Sep;28(9):825-32 [2945914]
J Anal Toxicol. 1982 Jan-Feb;6(1):49-52 [6281576]
J Anal Toxicol. 1984 Jul-Aug;8(4):192-6 [6471820]
JAMA. 1985 Apr 26;253(16):2382-7 [2984441]
J Anal Toxicol. 1985 Jul-Aug;9(4):156-60 [4033071]
J Occup Med. 1986 Aug;28(8):547-52 [3746471]
J Anal Toxicol. 1981 Sep-Oct;5(5):201-8 [7321544]
N1  - Last updated - 2017-01-17
ER  - 



TY  - RPRT
T1  - Council on Graduate Medical Education First Report of the Council. Volume I.
AN  - 63023699; ED316167
AB  - The report contains 44 recommendations on issues related to both undergraduate and graduate medical education. Among 10 principles identified are: the goal increased representation of minorities in the health professions and the importance of considering effects of total health care costs in the Nation. Initial chapters are concerned with legislative background; structure, principles, and approach used by the Council; and an overview of medical education. The recommendations and conclusions are concerned with the following areas: physician supply in the aggregate, geographic distribution of physicians, minority representation in medicine, primary care and other physician specialties, financing graduate medical education, Medicare financing of direct and indirect costs of graduate medical education, foreign medical graduates and access to graduate medical education, foreign medical graduates national relations, structure and content of medical education, and data and research issues. Also noted are long-term agenda considerations. A glossary provides definitions of 45 key terms. Two appendices provide legislative documentation. This document contains 65 references. (SM)
Y1  - 1988/07/01/
PY  - 1988
DA  - 1988 Jul 01
SP  - 80
KW  - Council on Graduate Medical Education
KW  - ERIC, Resources in Education (RIE)
KW  - Graduate Study
KW  - Access to Education
KW  - Educational Finance
KW  - Higher Education
KW  - Medical Education
KW  - Health Care Costs
KW  - Foreign Students
KW  - Demography
KW  - Minority Groups
KW  - Educational Planning
KW  - Graduate Medical Students
KW  - Graduate Medical Education
KW  - Physicians
KW  - Foreign Medical Graduates
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63023699?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - For Volume II, see HE 023 293.
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Council on Graduate Medical Education First Report of the Council. Volume II.
AN  - 63023658; ED316168
AB  - This volume primarily contains the detailed reports of the subcommittees on physician manpower, foreign medical graduates, financing of graduate medical education, and minority representation in medicine. Detailed background information and considerations used by the subcommittee in developing the conclusions and recommendations are provided. Comments by individual Council members and a cross-reference display of the Council's conclusions and recommendations are also included. The three appendices offer: an executive summary from Volume I of the first report of the Council; a summary of public hearing, November 19-20, 1987 and a glossary of 46 key terms. (SM)
Y1  - 1988/07/01/
PY  - 1988
DA  - 1988 Jul 01
SP  - 134
KW  - ERIC, Resources in Education (RIE)
KW  - Graduate Study
KW  - Educational Finance
KW  - Higher Education
KW  - Medical Education
KW  - Health Care Costs
KW  - Foreign Students
KW  - Demography
KW  - Minority Groups
KW  - Educational Planning
KW  - Graduate Medical Students
KW  - Graduate Medical Education
KW  - Physicians
KW  - Foreign Medical Graduates
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63023658?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - For Volume I, see HE 023 292.
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - High-performance liquid chromatographic determination of aryl N-methylcarbamate residues using post-column hydrolysis electrochemical detection.
AN  - 78410947; 3417824
AB  - A high-performance liquid chromatographic technique is reported which selectively detects the phenolic moiety of aryl N-methylcarbamates at low nanogram levels. The carbamates are separated on a C-8 column using an acetonitrile-water gradient mobile phase. The eluted carbamates are hydrolyzed in-line by post-column addition of base, which also serves as electrolyte in the electrochemical (coulometric) detection of the resulting phenols. The technique was tested with six carbamates (bufencarb, carbaryl, carbofuran, 3-hydroxycarbofuran, isoprocarb and methiocarb) and four crops (apples, cabbage, grapes and tomatoes). Optimum detector responses and stability for the carbamates were attained at 0.60 V. Detector response to the carbamates in the presence of crop coextractives was 99% of theoretical with a standard deviation of 2.8% at the 0.05- to 0.1-ppm fortification level. The lower limit of quantitation is 0.01 ppm. Other electrochemical detectors were evaluated for suitability for this work.
JF  - Journal of chromatography
AU  - Krause, R T
AD  - Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/06/17/
PY  - 1988
DA  - 1988 Jun 17
SP  - 333
EP  - 343
VL  - 442
KW  - Carbamates
KW  - 0
KW  - Insecticides
KW  - Pesticide Residues
KW  - Index Medicus
KW  - Oxidation-Reduction
KW  - Food Analysis
KW  - Vegetables -- analysis
KW  - Electrochemistry
KW  - Hydrolysis
KW  - Chromatography, High Pressure Liquid
KW  - Carbamates -- analysis
KW  - Pesticide Residues -- analysis
KW  - Insecticides -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-27
N1  - Date created - 1988-10-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Somatotropin safety--a short regulatory overview.
AN  - 78388212; 3045062
JF  - Journal of the American Veterinary Medical Association
AU  - Apostolou, A
AD  - Division of Toxicology, Food and Drug Administration, Rockville, MD 20857.
Y1  - 1988/06/15/
PY  - 1988
DA  - 1988 Jun 15
SP  - 1698
EP  - 1700
VL  - 192
IS  - 12
SN  - 0003-1488, 0003-1488
KW  - Recombinant Proteins
KW  - 0
KW  - Growth Hormone
KW  - 9002-72-6
KW  - Index Medicus
KW  - United States
KW  - Meat
KW  - Animals
KW  - United States Food and Drug Administration
KW  - Milk
KW  - Recombinant Proteins -- adverse effects
KW  - Species Specificity
KW  - Female
KW  - Pregnancy
KW  - Lactation -- drug effects
KW  - Growth Hormone -- adverse effects
KW  - Cattle -- physiology
KW  - Food Contamination
KW  - Veterinary Medicine
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-29
N1  - Date created - 1988-09-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Metabolism of bis(2-methoxyethyl) ether in the adult male rat: evaluation of the principal metabolite as a testicular toxicant.
AN  - 78244407; 3376111
AB  - The metabolism of the reproductive toxicant bis(2-methoxyethyl) ether was studied in male Sprague-Dawley rats, and the principal metabolite (2-methoxyethoxy)acetic acid and its metabolic precursor 2-(2-methoxyethoxy)ethanol were evaluated separately as testicular toxicants. For the metabolism study, rats were given single po doses of [1,2-ethylene-14C]bis(2-methoxyethyl) ether at 5.1 or 0.051 mmol/kg body wt. Within 96 hr, approximately 86 to 90% of the radioactivity was excreted in the urine. Urinary metabolites were separated by high-performance liquid chromatography and isolated for characterization by gas chromatography-mass spectrometry. The principal urinary metabolite, accounting for 67.9 +/- 3.3% of the administered high dose and 70.3 +/- 1.3% of the low dose, was identified as (2-methoxyethoxy)acetic acid. A second metabolite, representing 6.2 +/- 0.8% of the high dose and 5.8 +/- 0.8% of the low dose, was identified as methoxyacetic acid, a previously recognized testicular toxicant. In the toxicity study, (2-methoxyethoxy)acetic acid and 2-(2-methoxyethoxy)ethanol were administered to rats at 5.1 mmol/kg body wt by gavage as single daily doses for as many as 20 consecutive days. The testes of rats killed 24 hr after the administration of even numbered doses showed no gross or microscopic abnormalities. These results are in contrast to the previously reported testicular atrophy evoked after as few as 8 daily doses of the parent compound, bis(2-methoxyethyl) ether, tested under the same experimental conditions. Thus, the testicular toxicity reported for bis(2-methoxyethyl) ether could be explained by the presence of a minor metabolite, methoxyacetic acid.
JF  - Toxicology and applied pharmacology
AU  - Cheever, K L
AU  - Richards, D E
AU  - Weigel, W W
AU  - Lal, J B
AU  - Dinsmore, A M
AU  - Daniel, F B
AD  - Department of Health and Human Services, Centers for Disease Control, Cincinnati, Ohio 45226.
Y1  - 1988/06/15/
PY  - 1988
DA  - 1988 Jun 15
SP  - 150
EP  - 159
VL  - 94
IS  - 1
SN  - 0041-008X, 0041-008X
KW  - Acetates
KW  - 0
KW  - Carbon Radioisotopes
KW  - Ethylene Glycols
KW  - Methyl Ethers
KW  - methoxyacetic acid
KW  - F11T1H7Q7W
KW  - diglyme
KW  - M4BH3X0MVZ
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Methyl Ethers -- metabolism
KW  - Dealkylation
KW  - Animals
KW  - Methyl Ethers -- toxicity
KW  - Acetates -- toxicity
KW  - Male
KW  - Chromatography, High Pressure Liquid
KW  - Ethylene Glycols -- toxicity
KW  - Testis -- drug effects
KW  - Ethylene Glycols -- metabolism
KW  - Testis -- pathology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Metabolism+of+bis%282-methoxyethyl%29+ether+in+the+adult+male+rat%3A+evaluation+of+the+principal+metabolite+as+a+testicular+toxicant.&rft.au=Cheever%2C+K+L%3BRichards%2C+D+E%3BWeigel%2C+W+W%3BLal%2C+J+B%3BDinsmore%2C+A+M%3BDaniel%2C+F+B&rft.aulast=Cheever&rft.aufirst=K&rft.date=1988-06-15&rft.volume=94&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-08
N1  - Date created - 1988-07-08
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The preliminary report of the findings of the aspirin component of the ongoing Physicians' Health Study. The FDA perspective on aspirin for the primary prevention of myocardial infarction.
AN  - 78216849; 3367492
JF  - JAMA
AU  - Young, F E
AU  - Nightingale, S L
AU  - Temple, R A
AD  - Office of Health Affairs, Food and Drug Administration, Rockville, Md. 20857.
Y1  - 1988/06/03/
PY  - 1988
DA  - 1988 Jun 03
SP  - 3158
EP  - 3160
VL  - 259
IS  - 21
SN  - 0098-7484, 0098-7484
KW  - Aspirin
KW  - R16CO5Y76E
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Double-Blind Method
KW  - Random Allocation
KW  - Humans
KW  - Aged
KW  - Research Design
KW  - Cerebrovascular Disorders -- epidemiology
KW  - United States Food and Drug Administration
KW  - Cerebrovascular Disorders -- chemically induced
KW  - Aged, 80 and over
KW  - Risk Factors
KW  - Middle Aged
KW  - Physicians
KW  - Drug Labeling
KW  - Male
KW  - Aspirin -- adverse effects
KW  - Aspirin -- therapeutic use
KW  - Myocardial Infarction -- prevention & control
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=The+preliminary+report+of+the+findings+of+the+aspirin+component+of+the+ongoing+Physicians%27+Health+Study.+The+FDA+perspective+on+aspirin+for+the+primary+prevention+of+myocardial+infarction.&rft.au=Young%2C+F+E%3BNightingale%2C+S+L%3BTemple%2C+R+A&rft.aulast=Young&rft.aufirst=F&rft.date=1988-06-03&rft.volume=259&rft.issue=21&rft.spage=3158&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-22
N1  - Date created - 1988-06-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Malignant mesothelioma. A cluster in a native American pueblo.
AN  - 78215585; 3367951
JF  - The New England journal of medicine
AU  - Driscoll, R J
AU  - Mulligan, W J
AU  - Schultz, D
AU  - Candelaria, A
AD  - Department of Internal Medicine, United States Public Health Service Indian Hospital, Santa Fe, N.M.
Y1  - 1988/06/02/
PY  - 1988
DA  - 1988 Jun 02
SP  - 1437
EP  - 1438
VL  - 318
IS  - 22
SN  - 0028-4793, 0028-4793
KW  - Environmental Pollutants
KW  - 0
KW  - Asbestos
KW  - 1332-21-4
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Asbestos -- analysis
KW  - Culture
KW  - Humans
KW  - New Mexico
KW  - Environmental Pollutants -- analysis
KW  - Space-Time Clustering
KW  - Mesothelioma -- epidemiology
KW  - Indians, North American
KW  - Mesothelioma -- etiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-22
N1  - Date created - 1988-06-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Inflammatory potential of grain dust.
AN  - 78804352; 3268104
AB  - A comparative analysis of toxicity and inflammatory potential of spring wheat, oat, corn, and flax seed was performed. The extracts were examined by quantification of gram-negative bacterial endotoxin and protein contents, chemotaxis for purified human polymorphonuclear leukocytes, and several alveolar macrophage functions including phagocytosis, release of lactate dehydrogenase, macromolecular synthesis (protein and RNA), and interleukin-1 production. The results suggested that the extracts of all four grain dusts inhibited protein synthesis and decreased phagocytosis of alveolar macrophages at 7.5-25 mg/ml. Protein synthesis was inhibited to 40.2% of control and phagocytosis to 47.9% of control. Interleukin-1 production was stimulated, as indicated by a stimulation index range from 3.8-fold to 14.3-fold over controls. The activity of these grain dust extracts did not correlate with the endotoxin content of the samples. The data demonstrate that the extracts of all four dusts produced ill effects in rat alveolar macrophages in vitro and suggested a potential hazard to agricultural workers exposed to grain dust.
JF  - Biomedical and environmental sciences : BES
AU  - Ye, T T
AU  - Lewis, D M
AU  - Sorenson, W G
AU  - Olenchock, S A
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505.
Y1  - 1988/06//
PY  - 1988
DA  - June 1988
SP  - 115
EP  - 124
VL  - 1
IS  - 1
SN  - 0895-3988, 0895-3988
KW  - Air Pollutants
KW  - 0
KW  - Bacterial Toxins
KW  - Culture Media
KW  - Dust
KW  - Endotoxins
KW  - Interleukin-1
KW  - Plant Extracts
KW  - L-Lactate Dehydrogenase
KW  - EC 1.1.1.27
KW  - Index Medicus
KW  - Triticum
KW  - Interleukin-1 -- biosynthesis
KW  - Humans
KW  - L-Lactate Dehydrogenase -- analysis
KW  - Occupational Diseases -- etiology
KW  - Culture Media -- analysis
KW  - Interleukin-1 -- analysis
KW  - Plant Extracts -- analysis
KW  - Plant Extracts -- pharmacology
KW  - Respiratory Hypersensitivity -- etiology
KW  - Zea mays
KW  - Cells, Cultured
KW  - Inflammation -- etiology
KW  - Phagocytosis -- drug effects
KW  - Endotoxins -- analysis
KW  - Pulmonary Alveoli
KW  - Dust -- analysis
KW  - Bacterial Toxins -- analysis
KW  - Macrophages -- physiology
KW  - Air Pollutants -- analysis
KW  - Macrophages -- drug effects
KW  - Air Pollutants -- toxicity
KW  - Edible Grain -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-12-05
N1  - Date created - 1989-12-05
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Erratum In:
Biomed Environ Sci 1989 Jun;2(2):174
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Risk assessment and management models in development.
AN  - 78799828; 3077261
AB  - Traditionally toxicology was the science of poisons and antidotes. Because of societal and historical reasons, there developed a need to determine public hazard. This need has resulted in regulatory toxicology, the science of how to evaluate public health and environmental safety by evaluating the possibility of hazard or injury from the use of a substance to humans under practical conditions of use and exposure. The intense investigation, especially in this century, made to address these concerns has led to a significant broadening of the knowledge base in toxicology and to a new capacity to alter toxicity. How the risk of a toxic endpoint is assessed and the steps taken to assure safety are part of a process termed risk management. Managing risks can affect society, public health, employment, and international economics. It therefore includes, in addition to information on toxicity, many other factors such as values, politics, and economics. In order to provide a description of how risks are managed in a society such as the United States, some background about why certain risks are of concern is given, and how this concern is manifest and the methods of managing risk with an emphasis on regulatory toxicology are discussed.
JF  - Biomedical and environmental sciences : BES
AU  - Hart, R W
AU  - Turturro, A
AD  - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1988/06//
PY  - 1988
DA  - June 1988
SP  - 71
EP  - 78
VL  - 1
IS  - 1
SN  - 0895-3988, 0895-3988
KW  - Index Medicus
KW  - United States
KW  - Environmental Health
KW  - Risk Management
KW  - Toxicology
KW  - Models, Theoretical
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-12-05
N1  - Date created - 1989-12-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Mineralization of polycyclic aromatic hydrocarbons by a bacterium isolated from sediment below an oil field.
AN  - 78413687; 3415226
AB  - Microbiological analyses of sediments chronically exposed to petrogenic hydrocarbons resulted in the isolation of a gram-positive, rod-shaped bacterium which mineralized naphthalene (59.5% of the original amount), phenanthrene (50.9%), fluoranthene (89.7%), pyrene (63.0%), 1-nitropyrene (12.3%), 3-methylcholanthrene (1.6%), and 6-nitrochrysene (2.0%) to carbon dioxide when grown for 2 weeks in pure culture with organic nutrients. The bacterium tolerated salt concentrations up to 4% and grew well at 24 to 30 degrees C. The use of this bacterium may be an attractive alternative to existing physicochemical methods for the remediation of polycyclic aromatic hydrocarbons in the environment.
JF  - Applied and environmental microbiology
AU  - Heitkamp, M A
AU  - Cerniglia, C E
AD  - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1988/06//
PY  - 1988
DA  - June 1988
SP  - 1612
EP  - 1614
VL  - 54
IS  - 6
SN  - 0099-2240, 0099-2240
KW  - Culture Media
KW  - 0
KW  - Polycyclic Compounds
KW  - Index Medicus
KW  - Biodegradation, Environmental
KW  - Soil Microbiology
KW  - Gram-Positive Bacteria -- metabolism
KW  - Polycyclic Compounds -- metabolism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Mineralization+of+polycyclic+aromatic+hydrocarbons+by+a+bacterium+isolated+from+sediment+below+an+oil+field.&rft.au=Heitkamp%2C+M+A%3BCerniglia%2C+C+E&rft.aulast=Heitkamp&rft.aufirst=M&rft.date=1988-06-01&rft.volume=54&rft.issue=6&rft.spage=1612&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-05
N1  - Date created - 1988-10-05
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Adv Appl Microbiol. 1984;30:31-71 [6442534]
Cancer. 1981 May 15;47(10):2327-45 [7272889]
Appl Environ Microbiol. 1987 Jan;53(1):129-36 [3827241]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Acute flank pain and hematuria: lessons from adverse drug reaction reporting.
AN  - 78407267; 3417877
JF  - Journal of clinical pharmacology
AU  - Harter, J G
AD  - Anti-inflammatory Drug Products, Group Food and Drug Administration, Rockville, Maryland 20857.
Y1  - 1988/06//
PY  - 1988
DA  - June 1988
SP  - 560
EP  - 565
VL  - 28
IS  - 6
SN  - 0091-2700, 0091-2700
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - 0
KW  - Index Medicus
KW  - Humans
KW  - Hematuria -- chemically induced
KW  - Pain -- chemically induced
KW  - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Acute+flank+pain+and+hematuria%3A+lessons+from+adverse+drug+reaction+reporting.&rft.au=Harter%2C+J+G&rft.aulast=Harter&rft.aufirst=J&rft.date=1988-06-01&rft.volume=28&rft.issue=6&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-24
N1  - Date created - 1988-10-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Procainamide induces a transitory impairment of B cell mitogenesis in beagle dogs.
AN  - 78353813; 3042350
AB  - Beagle dogs (3 to 6 years old) were treated with 100-150 mg procainamide HC1/kg/day. After 2, 5, and 9 months of treatment, peripheral blood lymphocytes were isolated and stimulated with pokeweed mitogen. The data demonstrated a suppression of mitogenesis only at 2 and 5 months after procainamide treatment. The lymphocytes from dogs treated for 9 months had a normal response to pokeweed mitogen. At no time during this experiment were any significant levels of serum antinuclear antibodies detected nor was any change in the number of cycling lymphocytes apparent in the experimental versus control groups. The resting membrane potential of both control and experimental groups was similar and pokeweed mitogen depolarized the cells from both groups.
JF  - Drug and chemical toxicology
AU  - Mulhern, S A
AU  - Daguillard, F
AU  - Robinson, C J
AU  - Balazs, T
AD  - Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/06//
PY  - 1988
DA  - June 1988
SP  - 167
EP  - 179
VL  - 11
IS  - 2
SN  - 0148-0545, 0148-0545
KW  - Mitogens
KW  - 0
KW  - DNA
KW  - 9007-49-2
KW  - methylthymidine
KW  - 958-74-7
KW  - Procainamide
KW  - L39WTC366D
KW  - Thymidine
KW  - VC2W18DGKR
KW  - Index Medicus
KW  - Mitogens -- pharmacology
KW  - Animals
KW  - Cell Division -- drug effects
KW  - DNA -- biosynthesis
KW  - Thymidine -- metabolism
KW  - Dogs
KW  - Flow Cytometry
KW  - Membrane Potentials -- drug effects
KW  - Time Factors
KW  - Fluorescent Antibody Technique
KW  - Female
KW  - Male
KW  - Thymidine -- analogs & derivatives
KW  - B-Lymphocytes -- drug effects
KW  - Mitosis -- drug effects
KW  - Procainamide -- toxicity
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78353813?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Procainamide+induces+a+transitory+impairment+of+B+cell+mitogenesis+in+beagle+dogs.&rft.au=Mulhern%2C+S+A%3BDaguillard%2C+F%3BRobinson%2C+C+J%3BBalazs%2C+T&rft.aulast=Mulhern&rft.aufirst=S&rft.date=1988-06-01&rft.volume=11&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-22
N1  - Date created - 1988-09-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Microsomal metabolism of 1-nitrobenzo[e]pyrene to a highly mutagenic K-region dihydrodiol.
AN  - 78222834; 3286032
AB  - Aerobic metabolism of 1-nitrobenzo[e]pyrene (1-nitro-BeP) by rat liver microsomes produced 1-nitro-BeP trans-4,5-dihydrodiol, 6-hydroxy-1-nitro-BeP, and 8-hydroxy-1-nitro-BeP. When 3,3,3-trichloropropylene 1,2-oxide was incorporated into the metabolism, 1-nitro-BeP 4,5-oxide was the predominant metabolite, and 1-nitro-BeP trans-4,5-dihydrodiol was not detected. All of the metabolites were purified by both reversed- and normal-phase HPLC and characterized by analysis of their mass and 500 MHz proton NMR spectral data. 1-Nitro-BeP was not metabolized under hypoxic conditions. 1-Nitro-BeP and its four metabolites were assayed in Salmonella typhimurium tester strains TA98, TA98NR and TA98/1,8-DNP6, both in the presence and absence of S9 activation. As predicted, 1-nitro-BeP was a weak mutagen without S9 (2 revertants/micrograms in TA98); the addition of S9 resulted in approximately 18, 17 and 4 revertants/micrograms in TA98, TA98NR and TA98/1,8-DNP6 respectively. The two phenolic metabolites were mutagenic both in the presence and absence of S9, producing moderate responses (19-84 revertants/micrograms). In addition, while the 1-nitro-BeP 4,5-oxide was only weakly mutagenic in TA98 (6-14 revertants/micrograms), 1-nitro-BeP trans-4,5-dihydrodiol was unexpectedly potent (approximately 300 revertants/micrograms both with and without S9). These results indicate that microsomal epoxidation of 1-nitro-BeP followed by epoxide hydrolase-catalyzed hydrolysis of the resulting epoxide to the 1-nitro-BeP trans-4,5-dihydrodiol results in the most potent mutagenic derivatives. The weak mutagenicity of 1-nitro-BeP 4,5-oxide demonstrates that not all epoxides of nitrated polycyclic aromatic hydrocarbons (PAHs) are more mutagenic than the corresponding parent nitro-PAHs. Also, the lower S9-mediated mutagenicity of 1-nitro-BeP in TA98/1,8-DNP6 compared with TA98 indicates that the mutagenicity of 1-nitro-BeP is dependent upon nitroreduction and transesterification. Finally, we previously hypothesized that nitrated PAHs with their nitro substituents perpendicular or nearly perpendicular to the aromatic rings are very weak or nondirect-acting mutagens in Salmonella typhimurium tester strains. The results reported in this communication demonstrate that ring-oxidized derivatives of nitro-PAHs do not always follow this structure--mutagenicity correlation.
JF  - Carcinogenesis
AU  - Fu, P P
AU  - Heflich, R H
AU  - Von Tungeln, L S
AU  - Miranda, H Z
AU  - Evans, F E
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/06//
PY  - 1988
DA  - June 1988
SP  - 951
EP  - 958
VL  - 9
IS  - 6
SN  - 0143-3334, 0143-3334
KW  - Benzopyrenes
KW  - 0
KW  - Mutagens
KW  - 1-nitrobenzo(e)pyrene
KW  - 91259-16-4
KW  - Index Medicus
KW  - Rats
KW  - Mass Spectrometry
KW  - Animals
KW  - Mutagenicity Tests
KW  - Biotransformation
KW  - Salmonella typhimurium -- drug effects
KW  - Aerobiosis
KW  - Magnetic Resonance Spectroscopy
KW  - Mutagens -- metabolism
KW  - Microsomes, Liver -- metabolism
KW  - Benzopyrenes -- pharmacology
KW  - Benzopyrenes -- metabolism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Microsomal+metabolism+of+1-nitrobenzo%5Be%5Dpyrene+to+a+highly+mutagenic+K-region+dihydrodiol.&rft.au=Fu%2C+P+P%3BHeflich%2C+R+H%3BVon+Tungeln%2C+L+S%3BMiranda%2C+H+Z%3BEvans%2C+F+E&rft.aulast=Fu&rft.aufirst=P&rft.date=1988-06-01&rft.volume=9&rft.issue=6&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-11
N1  - Date created - 1988-07-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - GUIDELINES FOR EFFECTIVE SCHOOL HEALTH EDUCATION TO PREVENT THE SPREAD OF AIDS
AN  - 1437912173
JF  - Health Education
Y1  - 1988/06/01/
PY  - 1988
DA  - 1988 Jun 01
SP  - 6
CY  - Reston, VA
PB  - American Alliance for Health, Physical Education, Recreation, and Dance
VL  - 19
IS  - 3
SN  - 0097-0050
KW  - Education
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-01-10
ER  - 



TY  - JOUR
T1  - Circadian variation in the induction of intestinal tumors by N-methyl-N-nitrosourea in male C57BL/6N mice.
AN  - 78176710; 3357199
AB  - Male C57BL/6N mice were administered a single ip injection of 30 mg of N-methyl-N-nitrosourea (MNU)/kg of body weight. Additional groups were treated similarly every 3 hours for the next 24 hours. Adenocarcinomas of the small intestine were the major treatment-related tumors, with the total incidence being 38% at 250 days after injection. There was a significant circadian variation for tumor induction; the maximum number of intestinal tumors (approximately equal to 55%) tended to occur when the MNU was administered during the middle of the light period (6:00 to 18:00), while the tumor incidence was at a minimum (approximately equal to 10%) when the MNU was given in the middle of the dark phase (18:00 to 6:00). These data are discussed in relation to DNA synthesis and repair and MNU-induced cellular toxicity.
JF  - Journal of the National Cancer Institute
AU  - Beland, F A
AU  - Dooley, K L
AU  - Sheldon, W G
AU  - Delongchamp, R R
AD  - National Center for Toxicological Research (NCTR), Jefferson, AR 72079.
Y1  - 1988/05/04/
PY  - 1988
DA  - 1988 May 04
SP  - 325
EP  - 330
VL  - 80
IS  - 5
SN  - 0027-8874, 0027-8874
KW  - Methylnitrosourea
KW  - 684-93-5
KW  - DNA
KW  - 9007-49-2
KW  - O(6)-methyl-2'-deoxyguanosine
KW  - 964-21-6
KW  - Deoxyguanosine
KW  - G9481N71RO
KW  - Index Medicus
KW  - Animals
KW  - Deoxyguanosine -- metabolism
KW  - Adenocarcinoma -- chemically induced
KW  - DNA -- metabolism
KW  - Mice, Inbred C57BL
KW  - Intestine, Small
KW  - Mice
KW  - Male
KW  - Deoxyguanosine -- analogs & derivatives
KW  - Circadian Rhythm
KW  - Methylnitrosourea -- toxicity
KW  - Intestinal Neoplasms -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-26
N1  - Date created - 1988-05-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Cardiac effects of botulinal toxin.
AN  - 78433190; 3421785
AB  - Crystalline type A botulinal toxin rapidly caused temporary bradycardia and electrocardiographic (ECG) changes in mice, rats, rabbits and dogs. In addition, in the dog the force of contraction was measured and found to be depressed. The ECG changes were indicative of conduction defects. The hemagglutinin present in the toxin played no role in the effects on the heart, since a derivative toxin without hemagglutinin also caused these phenomena. The cardiac effects were spontaneously reversible in the intact animal without removal of the toxin. On the other hand, in the in vitro isolated heart of the rat, recovery from the cardiac effects occurred only after the toxin was washed out of the preparation. The findings are consistent with, but do not prove, a physical rather than a chemical mechanism for the effects of toxin on the heart.
JF  - Archives internationales de pharmacodynamie et de therapie
AU  - Lamanna, C
AU  - el-Hage, A N
AU  - Vick, J A
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, Washington DC 20204.
PY  - 1988
SP  - 69
EP  - 83
VL  - 293
SN  - 0003-9780, 0003-9780
KW  - Botulinum Antitoxin
KW  - 0
KW  - Atropine
KW  - 7C0697DR9I
KW  - Botulinum Toxins
KW  - EC 3.4.24.69
KW  - Index Medicus
KW  - Animals
KW  - Botulinum Antitoxin -- pharmacology
KW  - Mice, Inbred ICR
KW  - Vagotomy
KW  - Respiration -- drug effects
KW  - Mice
KW  - Rabbits
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Heart Rate -- drug effects
KW  - Electrocardiography
KW  - In Vitro Techniques
KW  - Dogs
KW  - Atropine -- pharmacology
KW  - Female
KW  - Male
KW  - Botulinum Toxins -- pharmacology
KW  - Heart -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-25
N1  - Date created - 1988-10-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Microsomal activation of 1- and 3-nitrobenzo[a]pyrene to mutagens in Chinese hamster ovary cells.
AN  - 78401340; 3045485
AB  - 1- and 3-nitrobenzo[a]pyrene (1- and 3-nitro-BaP) are environmental pollutants and are S9-mediated mutagens in the Chinese hamster ovary (CHO) cell/hypoxanthine-guanine phosphoribosyl transferase assay. In this study, we examined the pathways leading to the mutagenic activation of these compounds in CHO cells. The microsomal metabolites of 1- and 3-nitro-BaP, the 1- and 3-nitro-BaP trans-7,8-dihydroxy-7,8-dihydrodiols (trans-7,8-dihydrodiols) and the 1- and 3-nitro-BaP trans-9,10-dihydrodiols, were isolated and tested for mutagenicity. At the concentrations assayed, both trans-9,10-dihydrodiols were non-mutagenic with and without S9 activation. In contrast, the trans-7,8-dihydrodiols of 1- and 3-nitro-BaP were direct-acting mutagens and these responses were similar in magnitude to the S9-mediated mutagenicities of the parent nitro-BaPs. S9 increased the mutagenic responses of the trans-7,8-dihydrodiols approximately 20-fold. Inhibition of epoxide hydrolase decreased the S9-mediated mutagenicity of 1-nitro-BaP by half, but doubled the S9-mediated mutagenicity of 3-nitro-BaP. These results suggest that in CHO cells: (i) the major route of mutagenic activation of 1- and 3-nitro-BaP involves S9-generated derivatives of the trans-7,8-dihydrodiols, e.g. bay-region diol epoxides; (ii) reactive nitroarene oxides may contribute to mutation induction by 3-nitro-BaP; and (iii) metabolic routes involving trans-9,10-dihydrodiol formation result in detoxification.
JF  - Mutagenesis
AU  - Thornton-Manning, J R
AU  - Chou, M W
AU  - Fu, P P
AU  - Heflich, R H
AD  - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/05//
PY  - 1988
DA  - May 1988
SP  - 233
EP  - 237
VL  - 3
IS  - 3
SN  - 0267-8357, 0267-8357
KW  - Benzopyrenes
KW  - 0
KW  - Mutagens
KW  - Trichloroepoxypropane
KW  - 3083-23-6
KW  - 3-nitrobenzo(a)pyrene
KW  - 70021-98-6
KW  - 1-nitrobenzo(a)pyrene
KW  - 70021-99-7
KW  - Epoxide Hydrolases
KW  - EC 3.3.2.-
KW  - Index Medicus
KW  - Animals
KW  - Mutagenicity Tests
KW  - Cells, Cultured
KW  - Biotransformation
KW  - Liver
KW  - Subcellular Fractions
KW  - Epoxide Hydrolases -- antagonists & inhibitors
KW  - Trichloroepoxypropane -- pharmacology
KW  - Cricetinae
KW  - Microsomes -- metabolism
KW  - Benzopyrenes -- pharmacokinetics
KW  - Benzopyrenes -- toxicity
KW  - Mutagens -- pharmacokinetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-04
N1  - Date created - 1988-10-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Determination of dimetridazole and ipronidazole in feeds at cross-contamination levels.
AN  - 78310464; 3391941
AB  - A rapid method for the determination of dimetridazole and ipronidazole in feeds is described. The compounds are extracted from a borate buffer (pH 8.65) with benzene, partitioned into 1N HCl, and then partitioned back into benzene from a basic aqueous phase. The benzene extract is concentrated and injected onto a nonpolar (Apiezon L) gas chromatographic column for determination by 63Ni electron-capture detection. Recoveries from feeds of various composition, spiked at 0.2 ppm with both dimetridazole and ipronidazole, ranged from 70 to 115%; for the same feeds spiked at 1 ppm or more, the recoveries were greater than 80%. Carbadox, furazolidone, levamisole, oxytetracycline, chlortetracycline, sulfamethazine, sulfaquinoxaline, arsanilic acid, piperazine, penicillin, and commonly added vitamins and minerals do not interfere. A 2-dimensional thin layer chromatographic system is presented as a means of additional identification.
JF  - Journal - Association of Official Analytical Chemists
AU  - Hughes, D D
AD  - Food and Drug Administration, Kansas City, MO 64106.
PY  - 1988
SP  - 474
EP  - 477
VL  - 71
IS  - 3
SN  - 0004-5756, 0004-5756
KW  - Nitroimidazoles
KW  - 0
KW  - Ipronidazole
KW  - 045BU63E23
KW  - Dimetridazole
KW  - K59P7XNB8X
KW  - Index Medicus
KW  - Chromatography, Gas
KW  - Chromatography, Thin Layer
KW  - Electrochemistry
KW  - Ipronidazole -- analysis
KW  - Food Contamination -- analysis
KW  - Animal Feed -- analysis
KW  - Nitroimidazoles -- analysis
KW  - Dimetridazole -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-25
N1  - Date created - 1988-08-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Rapid gas chromatographic method for determining ethyl carbamate in alcoholic beverages with thermal energy analyzer detection.
AN  - 78310047; 3391950
AB  - A rapid column elution method has been developed for the determination of ethyl carbamate (EC) in alcoholic beverages. The beverage is mixed with Celite and packed in a column containing deactivated alumina capped with a layer of sodium sulfate. EC is then eluted with methylene chloride. The method, using a gas chromatograph-thermal energy analyzer with a nitrogen converter for detection and quantitation of EC, has been applied to a variety of alcoholic beverages. Recoveries +/- standard deviations of EC in wine and whisky fortified at the 20 and 133 micrograms/kg (ppb) levels averaged 87.3 +/- 5.3 and 88.7 +/- 3.6%, respectively. The method has a limit of detection of 1.5 ppb. Gas chromatography/mass spectrometry/mass spectrometry was used to confirm the identity and quantitation of EC in selected beverage extracts.
JF  - Journal - Association of Official Analytical Chemists
AU  - Canas, B J
AU  - Havery, D C
AU  - Joe, F L
AD  - Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204.
PY  - 1988
SP  - 509
EP  - 511
VL  - 71
IS  - 3
SN  - 0004-5756, 0004-5756
KW  - Indicators and Reagents
KW  - 0
KW  - Tetraethylammonium Compounds
KW  - Urethane
KW  - 3IN71E75Z5
KW  - Index Medicus
KW  - Chemistry
KW  - Chromatography, Gas
KW  - Wine -- analysis
KW  - Chemical Phenomena
KW  - Tetraethylammonium Compounds -- analysis
KW  - Gas Chromatography-Mass Spectrometry
KW  - Urethane -- analysis
KW  - Alcoholic Beverages -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+-+Association+of+Official+Analytical+Chemists&rft.atitle=Rapid+gas+chromatographic+method+for+determining+ethyl+carbamate+in+alcoholic+beverages+with+thermal+energy+analyzer+detection.&rft.au=Canas%2C+B+J%3BHavery%2C+D+C%3BJoe%2C+F+L&rft.aulast=Canas&rft.aufirst=B&rft.date=1988-05-01&rft.volume=71&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Journal+-+Association+of+Official+Analytical+Chemists&rft.issn=00045756&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-25
N1  - Date created - 1988-08-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Comparison of APHA and elevated temperature enrichment methods for recovery of Vibrio cholerae from oysters: collaborative study.
AN  - 78309667; 3391968
AB  - Two methods (the American Public Health Association (APHA) method and the elevated temperature method) for recovery of Vibrio cholerae from oysters were compared in a collaborative study. Oysters were inoculated with high (about 150 cells/g) and low (about 20 cells/g) levels of V. cholerae. The elevated temperature method gave a significantly higher (P less than 0.05) recovery rate and showed greater specificity (P less than 0.01), as determined by the confirmation rate of suspect colonies. The elevated temperature method required only 25% of the labor and materials necessary for the APHA method. The elevated temperature method has been adopted official first action.
JF  - Journal - Association of Official Analytical Chemists
AU  - DePaola, A
AU  - Motes, M L
AU  - McPhearson, R M
AD  - Food and Drug Administration, Fishery Research Branch, Dauphin Island, AL 36528.
PY  - 1988
SP  - 584
EP  - 589
VL  - 71
IS  - 3
SN  - 0004-5756, 0004-5756
KW  - Indicators and Reagents
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Temperature
KW  - Food Microbiology
KW  - Vibrio cholerae -- isolation & purification
KW  - Ostreidae -- microbiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-25
N1  - Date created - 1988-08-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Isolation and identification of Listeria monocytogenes in dairy products.
AN  - 78308427; 3134338
AB  - After an outbreak of listeriosis in Massachusetts in 1983, the ability of Listeria monocytogenes to survive in raw and pasteurized milk was investigated. An enrichment broth (EB) containing acriflavine, nalidixic acid, and cycloheximide was used to eliminate overgrowth of the culture by competing organisms, and a modification of McBride's agar (MMA) was used as the isolation medium. The culture was incubated 24 h at 30 degrees C. To isolate Listeria from soft cheese, the incubation period was lengthened to 1 week, and the EB culture was streaked to MMA at 1 and 7 days. Physical and biochemical patterns, the CAMP test, serological tests, and mouse pathogenicity studies were helpful in determining the identity of L. monocytogenes.
JF  - Journal - Association of Official Analytical Chemists
AU  - Lovett, J
AD  - Food and Drug Administration, Division of Microbiology, Cincinnati, OH 45226.
PY  - 1988
SP  - 658
EP  - 660
VL  - 71
IS  - 3
SN  - 0004-5756, 0004-5756
KW  - Culture Media
KW  - 0
KW  - Index Medicus
KW  - Food Microbiology
KW  - Cheese
KW  - Listeria monocytogenes -- pathogenicity
KW  - Listeria monocytogenes -- isolation & purification
KW  - Dairy Products -- analysis
KW  - Listeria monocytogenes -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-25
N1  - Date created - 1988-08-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Characterization of benzyl isothiocyanate and phenyl acetonitrile from papayas by mass spectrometry.
AN  - 78308249; 3391960
AB  - Two unidentified analytical responses in a papaya extract were structurally determined by mass spectrometry to be benzyl isothiocyanate and phenyl acetonitrile. Both these compounds have previously been shown to result from degradation of benzylglucosinolate that occurs naturally in the seeds of the fruit. Characterization by mass spectrometry has now provided a convenient mechanism to detect both these degradation compounds in extracts resulting from routine pesticide residue analysis.
JF  - Journal - Association of Official Analytical Chemists
AU  - Cairns, T
AU  - Siegmund, E G
AU  - Stamp, J J
AU  - Jacobs, R M
AD  - Food and Drug Administration, Office of Regulatory Affairs, Los Angeles, CA 90015.
PY  - 1988
SP  - 547
EP  - 550
VL  - 71
IS  - 3
SN  - 0004-5756, 0004-5756
KW  - Acetonitriles
KW  - 0
KW  - Isothiocyanates
KW  - Pesticide Residues
KW  - Thiocyanates
KW  - benzyl cyanide
KW  - 23G40PRP93
KW  - benzyl isothiocyanate
KW  - 871J6YOR8Q
KW  - Index Medicus
KW  - Gas Chromatography-Mass Spectrometry
KW  - Thiocyanates -- analysis
KW  - Fruit -- analysis
KW  - Pesticide Residues -- analysis
KW  - Acetonitriles -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-25
N1  - Date created - 1988-08-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Arachidonic acid metabolism of cultured peritoneal rat macrophages and its manipulation by nonsteroidal antiinflammatory agents.
AN  - 78307236; 3134311
AB  - [3H]Arachidonic acid (AA) metabolism by cultured rat peritoneal macrophages (M phi) was examined. Ninety percent of incorporated [3H]AA localized in phospholipids (phosphatidylcholine, 30%; phosphatidylinositol, 23.9%; phosphatidylethanolamine, 23.7%) whereas 8.3% and 1.5% was found in the free fatty acid and neutral lipid fractions. 12-O-tetradecanoate phorbol-13-acetate (TPA) induced the reduction of label from phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine (42%, 46% and 47%, respectively) and an accumulation of label into free fatty acids (34%) or neutral lipid (61%) fractions. Simultaneously, 12% of the incorporated label was released into the medium as [3H]6-keto prostaglandin (PG)F1 alpha, [3H]thromboxane B2 (TxB2), [3H]PGE2, [3H]hydroxyheptadecanoic acid (HHT), [3H]15-hydroxyeicosatetraenoic acid (HETE), [3H]12-HETE and [3H]AA. Exposure to 0.3-3 microM indomethacin reduced TPA-induced label release into the medium which was distinguished by dose-dependent reductions in all [3H]prostanoids as well as [3H]15- and [3H]12-HETE and a reciprocal increase in [3H]AA. Nordihydroguaiaretic acid (NDGA) altered AA metabolism at concentrations which approached its toxic dose (greater than 20 microM). Cells exposed to 10 microM NDGA reduced TPA-induced label release into the medium which was characterized by reductions in [3H]-TxB2, [3H]PGE2 and [3H]HHT, no change in [3H]15-HETE, [3H]12-HETE or [3H]AA and the appearance of [3H]PGF2 alpha. Cellular label redistributions of lipid fractions in cells exposed to NDGA or indomethacin were significantly less than that of control cultures indicating inhibition of acylhydrolase activity. Indomethacin or NDGA, therefore modify AA metabolism of cultured rat M phi by influencing more than one target enzyme.
JF  - Immunopharmacology
AU  - Marshall, L A
AD  - Laboratory of Cell Biology, U.S. Food and Drug Administration, Bethesda, MD.
PY  - 1988
SP  - 177
EP  - 187
VL  - 15
IS  - 3
SN  - 0162-3109, 0162-3109
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - 0
KW  - Arachidonic Acids
KW  - Prostaglandins
KW  - Arachidonic Acid
KW  - 27YG812J1I
KW  - Masoprocol
KW  - 7BO8G1BYQU
KW  - Tetradecanoylphorbol Acetate
KW  - NI40JAQ945
KW  - Indomethacin
KW  - XXE1CET956
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Cells, Cultured
KW  - Prostaglandins -- biosynthesis
KW  - Tetradecanoylphorbol Acetate -- pharmacology
KW  - Male
KW  - Masoprocol -- pharmacology
KW  - Indomethacin -- pharmacology
KW  - Arachidonic Acids -- metabolism
KW  - Macrophages -- metabolism
KW  - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-19
N1  - Date created - 1988-08-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Liquid chromatographic determination of tetracycline residues in animal feeds.
AN  - 78303385; 3391942
AB  - A liquid chromatographic method for the multiresidue determination of tetracyclines (TCs) in feeds is described. The levels of quantitation were 10 ppm each for tetracycline-HCl (TC), oxytetracycline (OTC), and chlortetracycline-HCl (CTC); the detection limit was 40 ppb for each. The calibration curves were linear between 2.5 and 100 ppm. The procedure involved double extraction with pH 2.0 and pH 4.5 McIlvain buffers, cleanup on a Sephadex LH-20 column, separation on a Nova-Pak C18 column, and detection at 370 nm. Recoveries of 10 micrograms/g of each TC in multiresidue feed samples ranged from 55.8 to 75.5% for OTC, 71.6 to 100% for TC, and 22.4 to 60.6% for CTC. The identities of the TCs were confirmed by thin layer chromatography.
JF  - Journal - Association of Official Analytical Chemists
AU  - Martinez, E E
AU  - Shimoda, W
AD  - Food and Drug Administration, Animal Drug Research Center, Denver, CO 80225.
PY  - 1988
SP  - 477
EP  - 480
VL  - 71
IS  - 3
SN  - 0004-5756, 0004-5756
KW  - Indicators and Reagents
KW  - 0
KW  - Solvents
KW  - Tetracyclines
KW  - Index Medicus
KW  - Chromatography, Liquid
KW  - Chromatography, Thin Layer
KW  - Drug Residues -- analysis
KW  - Tetracyclines -- analysis
KW  - Animal Feed -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-25
N1  - Date created - 1988-08-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Effects of postnatal DES treatment on uterine growth, development, and estrogen receptor levels.
AN  - 78258965; 3379960
AB  - The neonatal rodent appears to be an appropriate animal model for estrogen toxicity in the developing reproductive tract. Newborn rats were treated with diethylstilbestrol (DES) at human therapeutic doses (approx 1 mg/kg) during two ontogenetic periods (postnatal days 1-5 and 1-25). Treatment on days 1-5 doubled uterine wt by day 5; however, these uteri failed to grow after discontinuation of DES treatment. In contrast, uterine wt was 4-fold higher and DNA content was 2-fold higher than controls on days 10-25 with continued DES treatment. Total uterine estrogen receptor levels, depressed 60% by day 5 of DES treatment, partially recovered after discontinuation of DES treatment but remained 25% below controls on day 25. Receptor levels following DES on days 1-25 decreased to about 15% of the controls by day 15. Short-term DES treatment approximately halved uterine gland content while continued treatment almost completely inhibited gland appearance. DES effects on glands appear related to continued hypertrophy of the luminal epithelium, from which uterine glands are derived. Subsequent failure of uterine growth caused by DES treatment on days 1-5 is similar to clinical findings of hypoplastic uteri in DES-treated patients. Disruption of the normal ontogenetic patterns of estrogen receptor by DES may be involved. These data demonstrate abnormal patterns of growth, estrogen receptor levels and morphogenesis in uteri of rats treated postnatally with DES.
JF  - Journal of steroid biochemistry
AU  - Medlock, K L
AU  - Sheehan, D M
AU  - Nelson, C J
AU  - Branham, W S
AD  - Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/05//
PY  - 1988
DA  - May 1988
SP  - 527
EP  - 532
VL  - 29
IS  - 5
SN  - 0022-4731, 0022-4731
KW  - Receptors, Estrogen
KW  - 0
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Index Medicus
KW  - Rats
KW  - Animals, Newborn
KW  - Animals
KW  - Age Factors
KW  - Cell Nucleus -- metabolism
KW  - Female
KW  - Organ Size -- drug effects
KW  - Uterus -- metabolism
KW  - Uterus -- growth & development
KW  - Diethylstilbestrol -- pharmacology
KW  - Receptors, Estrogen -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-15
N1  - Date created - 1988-07-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The alveolar type II epithelial cell: a multifunctional pneumocyte.
AN  - 78218530; 3285521
AB  - The epithelial surface of the alveoli is composed of alveolar type I and type II cells. Alveolar type I cells comprise 96% of the alveolar surface area. These cells are extremely thin, thus, minimizing diffusion distance between the alveolar air space and pulmonary capillary blood. Type II cells are spherical pneumocytes which comprise only 4% of the alveolar surface area, yet they constitute 60% of alveolar epithelial cells and 10-15% of all lung cells. Four major functions have been attributed to alveolar type II cells: (1) synthesis and secretion of surfactant; (2) xenobiotic metabolism; (3) transepithelial movement of water; and (4) regeneration of the alveolar epithelium following lung injury. Therefore, alveolar type II cells play important roles in normal pulmonary function and in the response of the lung to toxic compounds which may cause lung damage. Techniques have now been developed to isolate and purify alveolar type II epithelial cells from lung tissue. Such cellular preparations afford bioassay systems to monitor the effects of occupational or environmental pollutants on alveolar pneumocytes and should yield important information concerning the etiology of pulmonary disease in the alveolar region of the lung.
JF  - Toxicology and applied pharmacology
AU  - Castranova, V
AU  - Rabovsky, J
AU  - Tucker, J H
AU  - Miles, P R
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia.
Y1  - 1988/05//
PY  - 1988
DA  - May 1988
SP  - 472
EP  - 483
VL  - 93
IS  - 3
SN  - 0041-008X, 0041-008X
KW  - Pharmaceutical Preparations
KW  - 0
KW  - Pulmonary Surfactants
KW  - Index Medicus
KW  - Oxidation-Reduction
KW  - Pulmonary Surfactants -- metabolism
KW  - Animals
KW  - Pharmaceutical Preparations -- metabolism
KW  - Epithelial Cells
KW  - Humans
KW  - Epithelium -- physiology
KW  - Body Water -- metabolism
KW  - Cell Separation
KW  - Pulmonary Alveoli -- cytology
KW  - Pulmonary Alveoli -- physiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-16
N1  - Date created - 1988-06-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography.
AN  - 78271440; 3384887
AB  - A high-performance liquid chromatographic procedure was developed for the isolation and quantitation of coumarin from vanilla-based liquid flavorings of Mexican origin. Forty products representing fourteen different Mexican brands were assayed for coumarin, vanillin, and ethyl vanillin by the proposed method. The procedure has been adapted to the analysis of other products including domestic vanilla extracts and imitation vanilla flavorings for vanillin, ethyl vanillin, 4-hydroxybenzaldehyde and piperonal. Chromatographic retention data for thirty-seven compounds associated with vanillin and vanilla products employing two mobile phase systems are presented.
JF  - Journal of chromatography
AU  - Thompson, R D
AU  - Hoffmann, T J
AD  - U.S. Food and Drug Administration, Department of Health and Human Services, Minneapolis, MN 55401.
Y1  - 1988/04/22/
PY  - 1988
DA  - 1988 Apr 22
SP  - 369
EP  - 382
VL  - 438
IS  - 2
KW  - Benzaldehydes
KW  - 0
KW  - Coumarins
KW  - Flavoring Agents
KW  - Indicators and Reagents
KW  - Plant Extracts
KW  - Ethanol
KW  - 3K9958V90M
KW  - vanillin
KW  - CHI530446X
KW  - Index Medicus
KW  - Mexico
KW  - Chromatography, Gas
KW  - Hydrogen-Ion Concentration
KW  - Reference Standards
KW  - Food Contamination -- analysis
KW  - Ethanol -- analysis
KW  - Plant Extracts -- analysis
KW  - Benzaldehydes -- analysis
KW  - Flavoring Agents -- analysis
KW  - Coumarins -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-11
N1  - Date created - 1988-08-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - NMR study of stacking interactions and conformational adjustments in the dinucleotide-carcinogen adduct 2'-deoxycytidylyl-(3----5)-2'-deoxy-8-(N-fluoren-2-ylac etamido)guanosi ne.
AN  - 78350733; 3401466
AB  - The conformation and dynamics of the dinucleotide d-CpG modified at the C(8) position of the guanine ring by the carcinogen 2-(acetylamino)fluorene has been investigated by high-field 1H NMR spectroscopy. A two-state analysis of chemical shift data has enabled estimation of the extent of intramolecular stacking in aqueous solution as a function of temperature. The stacking, which is mostly fluorene-cytosine, is virtually complete in the low-temperature range. The 500-MHz 1H NMR spectrum consists of two subspectra near ambient temperatures due to a 14.3 +/- 0.3 kcal/mol barrier to internal rotation about the amide bond in the stacked form. A large barrier to internal rotation about the guanyl-nitrogen bond at C(8) has also been ascertained, but separate NMR subspectra were not detected due to the predominance of one of the torsional diastereomers (alpha' = 90 degrees) in the fully stacked state. Problems of self-association and chemical exchange were identified and overcome to enable analysis of the sugar-phosphate backbone conformation utilizing coupling constants. For the exocyclic C(4')-C(5') bond of the deoxyguanosine moiety, there is a high gauche+ (gamma = 60 degrees) conformer population, which is uncommon for a purine nucleotide with a syn orientation about the glycosyl bond. The gauche- conformation (gamma = 300 degrees), which is normally present in syn purine nucleotides in solution, was not detected. The exocyclic C(5')-O(5') torsion of the deoxy-guanosine moiety remains near the classical energy minimum (beta = 180 degrees) in the major stacked conformations. The sugar ring of the deoxycytidine moiety is predominantly in the C2'-endo conformation, while the deoxyguanosine ring is a mixture of conformations, one of which appears to be unusually puckered. The results support intercalation models of modified DNA and suggest a looped-out structure, with the modified guanine being the first base in the loop. Such structures could explain the relatively rapid rate of repair and the frame-shift mutations of this type of adduct.
JF  - Biochemistry
AU  - Evans, F E
AU  - Levine, R A
AD  - Division of Biochemical Toxicology (HFT-110), Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1988/04/19/
PY  - 1988
DA  - 1988 Apr 19
SP  - 3046
EP  - 3055
VL  - 27
IS  - 8
SN  - 0006-2960, 0006-2960
KW  - Deoxycytosine Nucleotides
KW  - 0
KW  - Dinucleoside Phosphates
KW  - Deoxycytidine Monophosphate
KW  - 1032-65-1
KW  - Guanosine
KW  - 12133JR80S
KW  - deoxycytidylyl-(3'-5')-deoxyguanosine
KW  - 15178-66-2
KW  - 2'-deoxycytidylyl-(3--5)-2'-deoxy-8-(N-fluoren-2-ylacetamido)guanosine
KW  - 80229-05-6
KW  - 2-Acetylaminofluorene
KW  - 9M98QLJ2DL
KW  - Deoxyguanosine
KW  - G9481N71RO
KW  - Index Medicus
KW  - Magnetic Resonance Spectroscopy -- methods
KW  - Thermodynamics
KW  - Nucleic Acid Conformation
KW  - Guanosine -- chemical synthesis
KW  - Deoxycytidine Monophosphate -- analogs & derivatives
KW  - Guanosine -- analogs & derivatives
KW  - Deoxycytosine Nucleotides -- chemical synthesis
KW  - Deoxycytidine Monophosphate -- chemical synthesis
KW  - Deoxyguanosine -- analogs & derivatives
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-09
N1  - Date created - 1988-09-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein.
AN  - 78151397; 3350815
AB  - Chinese hamster ovary (CHO) cells cluster in the presence of pertussis toxin, a response that is correlated with the ADP-ribosylation of a Mr = 41,000 membrane protein by the toxin. A ricin-resistant line of CHO cells (CHO-15B) which specifically lacks the terminal NeuAc----Gal beta 4GlcNAc oligosaccharide sequence on glycoproteins did not cluster in response to pertussis toxin. These cells do contain the Mr = 41,000 protein substrate for the enzymatic activity of the toxin which suggests that pertussis toxin, like certain plant lectins, does not bind to or is not internalized by the CHO-15B cells. There was no evidence of pertussis toxin binding to gangliosides or neutral glycolipids isolated from CHO cells but the toxin bound to a Mr = 165,000 component in N-octyglucoside extracts of CHO cells that had been separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroblotted to nitrocellulose. Plant lectins from Ricinus communis and Erythina cristagalli detected a similar size band in CHO cells and also did not react with CHO-15B cells. Unlike pertussis toxin, these plant lectins recognized two other major bands in CHO cell extracts and reacted best after sialidase treatment of nitrocellulose transfers containing CHO cell extracts. Conversely, sialidase treatment abolished binding a pertussis toxin and wheat germ agglutinin, a plant lectin that reacts with multivalent sialic acid residues on glycoproteins, to the Mr = 165,000 band. Purified B oligomer of pertussis toxin also uniquely detected a Mr = 165,000 component in CHO cell extracts while the A subunit of pertussis toxin was unreactive. These results indicate that pertussis toxin binds to a CHO cell glycoprotein with N-linked oligosaccharides and that sialic acid contributes to the complementary receptor site for the toxin. In addition, they suggest that a glycoprotein may serve as a cell surface receptor for pertussis toxin and that this interaction is mediated by a lectin-like binding site located on the B oligomer.
JF  - The Journal of biological chemistry
AU  - Brennan, M J
AU  - David, J L
AU  - Kenimer, J G
AU  - Manclark, C R
AD  - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892.
Y1  - 1988/04/05/
PY  - 1988
DA  - 1988 Apr 05
SP  - 4895
EP  - 4899
VL  - 263
IS  - 10
SN  - 0021-9258, 0021-9258
KW  - Gangliosides
KW  - 0
KW  - Membrane Glycoproteins
KW  - Receptors, Mitogen
KW  - Virulence Factors, Bordetella
KW  - Wheat Germ Agglutinins
KW  - Adenosine Diphosphate Ribose
KW  - 20762-30-5
KW  - Cholera Toxin
KW  - 9012-63-9
KW  - Pertussis Toxin
KW  - EC 2.4.2.31
KW  - Index Medicus
KW  - Animals
KW  - Cricetulus
KW  - Ovary
KW  - Adenosine Diphosphate Ribose -- metabolism
KW  - Protein Binding
KW  - Molecular Weight
KW  - Female
KW  - Cell Line
KW  - Gangliosides -- metabolism
KW  - Cricetinae
KW  - Cholera Toxin -- metabolism
KW  - Wheat Germ Agglutinins -- metabolism
KW  - Virulence Factors, Bordetella -- metabolism
KW  - Receptors, Mitogen -- metabolism
KW  - Membrane Glycoproteins -- metabolism
KW  - Membrane Glycoproteins -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-02
N1  - Date created - 1988-05-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Biological characterization of human interleukin-2 mutant proteins. Structure-activity relationship studies.
AN  - 78145573; 3127390
AB  - Several human interleukin-2 (IL-2) mutant proteins have been produced previously by site-directed mutagenesis and found to have different capacities to induce T-cell proliferative activity. In this study, the abilities of these IL-2 mutant proteins to activate natural killer cells and to induce interferon-gamma production have been evaluated, and the binding of these proteins to IL-2 receptors analyzed. Natural killer cell activation and interferon-gamma induction assays showed that the relative activities of IL-2 mutant proteins were consistent with their relative activities in T-cell proliferation assay. Receptor-binding studies showed that the activities of most proteins correlated well with their respective affinities for high-affinity IL-2 receptors on CTLL-2 cells. Interestingly, although the mutant protein with deletion of cysteine 125 (des-Cys125) was biologically less active than the protein with substitution of alanine for cysteine 105 (Ala105), both proteins exhibited similar affinity. Des-Cys125, like IL-2 and Ala105, also caused down-regulation of high-affinity IL-2 receptors. Binding studies on MLA-144, a cell line expressing mainly intermediate-affinity IL-2 receptors (IL-2R beta), however, showed that des-Cys125 had much lower affinity than Ala105. These results suggest that binding of IL-2 and mutant proteins to the IL-2R beta component of the high-affinity receptor is essential for the induction of biological effects.
JF  - The Journal of biological chemistry
AU  - Liang, S M
AU  - Lee, N
AU  - Zoon, K C
AU  - Manischewitz, J F
AU  - Chollet, A
AU  - Liang, C M
AU  - Quinnan, G V
AD  - Division of Virology, Food and Drug Administration, Bethesda, Maryland 20892.
Y1  - 1988/04/05/
PY  - 1988
DA  - 1988 Apr 05
SP  - 4768
EP  - 4772
VL  - 263
IS  - 10
SN  - 0021-9258, 0021-9258
KW  - Interferon Inducers
KW  - 0
KW  - Interleukin-2
KW  - Receptors, Immunologic
KW  - Receptors, Interleukin-2
KW  - Interferon-gamma
KW  - 82115-62-6
KW  - Index Medicus
KW  - Lymphocyte Activation
KW  - Animals
KW  - Humans
KW  - Interferon-gamma -- biosynthesis
KW  - Mice
KW  - Killer Cells, Natural -- immunology
KW  - Cell Line
KW  - Receptors, Immunologic -- metabolism
KW  - Interleukin-2 -- immunology
KW  - Interleukin-2 -- genetics
KW  - Mutation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-02
N1  - Date created - 1988-05-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Benzo[a]pyrene: kinetics of in vitro bioactivation in relation to inhibition of viral interferon induction.
AN  - 78254379; 2837519
AB  - The kinetics of benzo[a]pyrene (BaP) bioactivation by rat liver S9 fraction was characterized on the basis of inhibition of influenza virus induction of interferon-alpha/beta (IFN-alpha/beta) in mammalian LLC-MK2 cell cultures. Both viral IFN induction and production phases were sensitive to the adverse effects of bioactivated BaP. The integral role of S9 for BaP bioactivation and the resultant inhibition of viral IFN induction was substantiated by dose-response relationships, time-dependency of effects, and reversibility of adverse reactivity. When preceded by the analog, benzo[e]pyrene (BeP), the inhibitive action of bioactivated BaP on IFN induction was abrogated. That the ability of exogenous IFN to confer antiviral cellular resistance was unaffected by bioactivated BaP indicates that neither requisite cellular protein nor enzyme syntheses were impaired. In cells pretreated with bioactivated BaP, influenza virus multiplication reached a level that was more than twofold higher than in normal cells which was a reflection of decreased IFN production. These findings further imply that neither virus inducer-cell interactions (attachment and penetration) nor requisite viral protein and RNA syntheses were affected appreciably. BaP was selectively cyto-antagonistic to critical inducer-processing phases of IFN induction. Of 32 different mammalian cell cultures tested for indigenous metabolizing enzyme-bioactivation of BaP, based on approximately equal to 50% resultant inhibition of IFN induction, only 37.5% were responsive.
JF  - Journal of interferon research
AU  - Hahon, N
AU  - Booth, J A
AD  - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, ALOSH, Morgantown, WV 26505.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
SP  - 151
EP  - 167
VL  - 8
IS  - 2
SN  - 0197-8357, 0197-8357
KW  - Interferon Inducers
KW  - 0
KW  - Benzo(a)pyrene
KW  - 3417WMA06D
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Cells, Cultured
KW  - Humans
KW  - Liver -- metabolism
KW  - Macaca mulatta
KW  - Influenza A virus -- physiology
KW  - Benzo(a)pyrene -- toxicity
KW  - Parainfluenza Virus 1, Human -- physiology
KW  - Benzo(a)pyrene -- pharmacokinetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-22
N1  - Date created - 1988-07-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Human class I MHC-restricted cytotoxic T-lymphocytes specific for human immunodeficiency virus envelope antigens.
AN  - 78251989; 2454643
AB  - Vaccines incorporating HIV envelope antigens are being developed for the prevention of AIDS. To determine whether HIV envelope antigens are recognized by human cytotoxic T-lymphocytes (CTL), we assessed class I MHC-restricted, HIV envelope antigen-specific cytotoxic activity of peripheral blood mononuclear cells (PBMC) from HIV-infected individuals, following in vitro stimulation. The target cells were human skin fibroblasts of known tissue type, infected with recombinant vaccinia viruses, either containing or lacking the whole HIV envelope gene. Ten out of 17 (59%) asymptomatic HIV-seropositive individuals demonstrated HIV envelope antigen-specific cytotoxicity at levels that were above those seen in HIV-seronegative controls. MHC restriction of cytotoxicity was evident in that 13 out of 19 (68%) of the targets matched for the tissue type of the donor at one or more class I MHC loci were lysed, but only two out of 18 (11%) mismatched targets (P = 0.0004). Both partial purification of effector cells and evidence of MHC restriction indicated that T-lymphocytes were responsible for the observed cytotoxicity. HIV envelope antigen-specific CTL can be detected following in vitro stimulation of the PBMC in many asymptomatic HIV-seropositive individuals. HIV envelope antigens are recognized by human CTL and are, therefore, potentially relevant immunogens for induction of HIV-specific CTL responses.
JF  - AIDS (London, England)
AU  - Shepp, D H
AU  - Daguillard, F
AU  - Mann, D
AU  - Quinnan, G V
AD  - Division of Virology, Food and Drug Administration, Bethesda, Maryland.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
SP  - 113
EP  - 117
VL  - 2
IS  - 2
SN  - 0269-9370, 0269-9370
KW  - Antigens, Viral
KW  - 0
KW  - Epitopes
KW  - HLA Antigens
KW  - Viral Envelope Proteins
KW  - Index Medicus
KW  - AIDS/HIV
KW  - Fibroblasts -- immunology
KW  - Vaccinia virus -- immunology
KW  - Humans
KW  - Cytotoxicity Tests, Immunologic
KW  - Cell Line
KW  - Viral Envelope Proteins -- immunology
KW  - HIV -- immunology
KW  - Antigens, Viral -- immunology
KW  - T-Lymphocytes, Cytotoxic -- classification
KW  - HLA Antigens -- immunology
KW  - T-Lymphocytes, Cytotoxic -- immunology
KW  - Epitopes -- immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-29
N1  - Date created - 1988-07-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Rubella virus replication: effect of interferons and actinomycin D.
AN  - 78249900; 2453976
AB  - The effect of alpha and gamma interferon (IFN alpha, IFN gamma) and actinomycin D on the expression of wild type rubella virus in African green monkey kidney cells (Vero 76) was studied. Viral protein synthesis in the infected cells was significantly reduced upon treatment of the cells with IFN alpha or IFN gamma, which is accompanied by the reduction in the level of both the (+) stranded and the (-) stranded viral RNAs. The residual rubella viral RNA from interferon-treated cells, however, was structurally intact as judged by Northern blot analysis and in vitro translation. These results suggest that the effect of IFN alpha and IFN gamma on rubella viral protein synthesis is both at the transcriptional and the translational level. The effect of actinomycin D on rubella virus replication was found to be time-dependent. It is much more pronounced during the eclipse phase of the viral growth (first 4 h) than after 8 h at which time actinomycin D had lesser effect. A similar effect on rubella virus replication was observed when alpha-amanitin was used instead of actinomycin D. These results were taken to indicate that during the viral infection, host cell DNA directs the synthesis of a cellular factor(s) which is essential for the viral replication. When the synthesis of this cellular factor(s) is terminated at an early stage of viral infection by actinomycin D or by alpha-amanitin, viral replication is impaired.
JF  - Virus research
AU  - Nakhasi, H L
AU  - Zheng, D X
AU  - Hewlett, I K
AU  - Liu, T Y
AD  - Division of Biochemistry and Biophysics, Food and Drug Administration, Bethesda, MD.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
SP  - 1
EP  - 15
VL  - 10
IS  - 1
SN  - 0168-1702, 0168-1702
KW  - Amanitins
KW  - 0
KW  - RNA, Viral
KW  - Viral Proteins
KW  - Viral Structural Proteins
KW  - Dactinomycin
KW  - 1CC1JFE158
KW  - Interferons
KW  - 9008-11-1
KW  - Index Medicus
KW  - Animals
KW  - Amanitins -- pharmacology
KW  - RNA, Viral -- biosynthesis
KW  - Viral Proteins -- biosynthesis
KW  - Vero Cells
KW  - Depression, Chemical
KW  - Rubella virus -- drug effects
KW  - Dactinomycin -- pharmacology
KW  - Virus Replication -- drug effects
KW  - Rubella virus -- physiology
KW  - Interferons -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-11
N1  - Date created - 1988-07-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Drug safety, pharmacoepidemiology, and regulatory decision making.
AN  - 78219504; 3371198
AB  - The safety or risk assessment of a pharmacotherapeutic agent begins early in its development and continues throughout its use cycle. The practice of pharmacoepidemiology is the art of using the sciences and the tools of science to generate information about pharmaceutical outcomes, including associated risks, in the postmarketing environment. A pharmacoepidemiologist must be capable of functioning with a matrix constructed of three components: a knowledge base, a conceptual framework, and an interpretive framework. From this perspective one can establish surveillance schemes, or understand a posed research question, select strategies, apply methodologies, and interpret the results of purposeful investigations. When conveyed to the risk manager, appropriately interpreted results of a properly conducted risk assessment can be used in regulatory decision making. Seven case studies are presented as examples of this approach.
JF  - Drug intelligence & clinical pharmacy
AU  - Nelson, R C
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
SP  - 336
EP  - 344
VL  - 22
IS  - 4
SN  - 0012-6578, 0012-6578
KW  - Index Medicus
KW  - United States
KW  - United States Food and Drug Administration
KW  - Substance Withdrawal Syndrome
KW  - Epidemiologic Methods
KW  - Humans
KW  - Product Surveillance, Postmarketing
KW  - Decision Making
KW  - Legislation, Drug -- trends
KW  - Drug-Related Side Effects and Adverse Reactions
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-30
N1  - Date created - 1988-06-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Progress in infection control in dental education.
AN  - 78169534; 2833539
AB  - While guidelines on proper infection control practices for dentistry have been available for over a decade, evidence suggests that recommended infection control practices are not universally employed in dentistry or dental education. A self-administered written survey was mailed to all U.S. dental schools in spring 1986 to assess the status of infection control curricula, standards, and practices. From the 47 schools that responded it is evident that, while progress is occurring in dental education relative to improved infection control standards and practice, much remains to be accomplished.
JF  - Journal of dental education
AU  - Corbin, S B
AU  - Scarlett, M I
AU  - Mitchell, E W
AD  - Prevention Policy Branch, Department of Health and Human Services, Washington, DC 20201.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
SP  - 192
EP  - 197
VL  - 52
IS  - 4
SN  - 0022-0337, 0022-0337
KW  - Dentistry
KW  - Index Medicus
KW  - United States
KW  - Dental Care
KW  - Attitude of Health Personnel
KW  - Centers for Disease Control and Prevention (U.S.)
KW  - Humans
KW  - Curriculum
KW  - Occupational Diseases -- prevention & control
KW  - Surveys and Questionnaires
KW  - Schools, Dental
KW  - American Dental Association
KW  - Education, Dental -- standards
KW  - Education, Dental -- trends
KW  - Communicable Disease Control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-16
N1  - Date created - 1988-05-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - National adverse drug reaction surveillance. 1986.
AN  - 78156563; 3355297
AB  - The collection of adverse drug reaction (ADR) reports by the Food and Drug Administration serves to provide additional information on the toxic reactions of drugs that often cannot be known before a drug is marketed. In 1986, a total of 53,547 ADR reports were received; 56% of these were made by US health care professionals based on observations made during usual clinical practice. The 1986 total represents an increase of 14% in ADR reporting over 1985, continuing a trend begun in 1981. While these increases are encouraging, US reporting rates are far below many other countries, and further encouragement of reporting must be done. Of these ADR reports, 24% involved serious reactions and 20% involved new drugs. An ADR report should be seen as a professional responsibility; reports are carefully analyzed and used.
JF  - Archives of internal medicine
AU  - Faich, G A
AU  - Dreis, M
AU  - Tomita, D
AD  - Office of Epidemiology and Biostatistics, US Food and Drug Administration, Rockville, Md.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
SP  - 785
EP  - 787
VL  - 148
IS  - 4
SN  - 0003-9926, 0003-9926
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Infant
KW  - Humans
KW  - Adult
KW  - Infant, Newborn
KW  - Middle Aged
KW  - Child
KW  - Adolescent
KW  - Male
KW  - Female
KW  - Child, Preschool
KW  - Evaluation Studies as Topic
KW  - United States Food and Drug Administration
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Product Surveillance, Postmarketing
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-29
N1  - Date created - 1988-04-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - BOOK
T1  - Indian Health Service: chart series book
AN  - 59482702; 1989-0201595
AB  - The IHS program and the health status of American Indians and Alaska natives; includes data, 1955-87.
JF  - Washington, DC 20201, April 1988. vi+92 pp.
Y1  - 1988/04//
PY  - 1988
DA  - April 1988
EP  - vi+92
PB  - Washington, DC 20201
KW  - Alaska -- Native races -- Health
KW  - Indians -- Health
KW  - United States -- Indian health service
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Washington, DC 20201 pa
N1  - Document feature - table(s), chart(s), map(s)
N1  - Last updated - 2016-09-28
ER  - 



TY  - RPRT
T1  - Cadmium in tobacco and its fate during smoking.
AN  - 15659725; 2301251
AB  - The authors suggest that the remaining cadmium, 50 to 55 percent, is lost in the sidestream during smoking and between puffs. This indicated that not only is the one smoking at risk from cadmium exposure, but so are the others present in vicinity.
JF  - NTIS, SPRINGIELD, VA (USA). 1988.
AU  - Petering, H G
AU  - Menden, EE
AU  - Michael, L W
Y1  - 1988/04//
PY  - 1988
DA  - Apr 1988
PB  - NTIS, SPRINGIELD, VA (USA)
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - cigarettes
KW  - tobacco
KW  - cadmium
KW  - H SE4.26:DRUGS AND ALCOHOL
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-248331/GAR.
N1  - Last updated - 2011-12-13
ER  - 



TY  - PAT
T1  - Process for manufacture of L-aspariginase from Erwinia chrysanthemi .
AN  - 14889282; 1731765
AU  - Lee, S-M
AU  - Ross, J T
AU  - Wroble, M H
PY  - 1988
IS  - US Patent 4,729,957
KW  - production
KW  - aspariginase
KW  - Erwinia chrysanthemi
KW  - patents
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts
KW  - W 30401:Enzymes and cofactors
KW  - A 01006:Enzymes & cofactors
KW  - W 30050:Patents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/229; Int. Cl. C12N 9/82, C12R 1/18.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Oxidative metabolism of the carcinogen 6-fluorobenzo[c]phenanthrene. Effect of a K-region fluoro substituent on the regioselectivity of cytochromes P-450 in liver microsomes from control and induced rats.
AN  - 78122240; 3346217
AB  - Oxidative metabolism of the carcinogen 6-fluorobenzo[c]phenanthrene (6-FB[c]Ph) was compared with that of benzo[c]phenanthrene (B[c]Ph) to elucidate the enhancement of carcinogenicity of B[c]Ph by the 6-fluoro substituent. Liver microsomes from untreated (control), phenobarbital-treated, and 3-methylcholanthrene-treated rats metabolized 6-FB[c]Ph at rates of 3.5, 1.5, and 7.7 nmol of products/nmol of cytochrome P-450/min, respectively. The rates of metabolism of B[c]Ph by the same microsomes were 2.9, 1.6, and 5.5 nmol of products/nmol of cytochrome P-450/min, respectively. Whereas the K-region 5,6-dihydrodiol was the major metabolite of B[c]Ph, the major metabolite of 6-FB[c]Ph was the K-region 7,8-oxide, which underwent slow rearrangement to an oxepin. Thus, the 6-fluoro substituent blocks oxidation at the 5,6-double bond and inhibits hydration of the K-region 7,8-oxide by epoxide hydrolase. Substitution with fluorine at C-6 caused an almost 2.5-fold increase in the percentages of the putative proximate carcinogens, i.e. benzo-ring dihydrodiols with bay-region double bonds, when liver microsomes from 3-methylcholanthrene-treated rats were used. Little or no increase was observed in their formation by liver microsomes from control or phenobarbital-treated rats. Interestingly, liver microsomes from control rats formed almost 3-fold as much 3,4-dihydrodiol as isosteric 9,10-dihydrodiol. The R,R-enantiomers of the 3,4- and 9,10-dihydrodiols and the S,S-enantiomer of the 7,8-dihydrodiol were predominantly formed by all three microsomal preparations.
JF  - The Journal of biological chemistry
AU  - Prasad, G K
AU  - Mirsadeghi, S
AU  - Boehlert, C
AU  - Byrd, R A
AU  - Thakker, D R
AD  - Laboratory of Molecular Pharmacology, Food and Drug Administration, Bethesda, Maryland 20892.
Y1  - 1988/03/15/
PY  - 1988
DA  - 1988 Mar 15
SP  - 3676
EP  - 3683
VL  - 263
IS  - 8
SN  - 0021-9258, 0021-9258
KW  - Carcinogens
KW  - 0
KW  - Hydrocarbons, Fluorinated
KW  - Phenanthrenes
KW  - 6-fluorobenzo(c)phenanthrene
KW  - 34236-47-0
KW  - Methylcholanthrene
KW  - 56-49-5
KW  - Cytochrome P-450 Enzyme System
KW  - 9035-51-2
KW  - benzo(c)phenanthrene
KW  - H22XVR3V8A
KW  - Phenobarbital
KW  - YQE403BP4D
KW  - Index Medicus
KW  - Rats
KW  - Oxidation-Reduction
KW  - Animals
KW  - Reference Values
KW  - Phenobarbital -- pharmacology
KW  - Magnetic Resonance Spectroscopy -- methods
KW  - Methylcholanthrene -- pharmacology
KW  - Molecular Conformation
KW  - Protein Binding
KW  - Male
KW  - Structure-Activity Relationship
KW  - Binding Sites
KW  - Phenanthrenes -- metabolism
KW  - Carcinogens -- metabolism
KW  - Microsomes, Liver -- metabolism
KW  - Microsomes, Liver -- drug effects
KW  - Cytochrome P-450 Enzyme System -- metabolism
KW  - Hydrocarbons, Fluorinated -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-14
N1  - Date created - 1988-04-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - MATCH: a maternal and child health information network.
AN  - 85247107; pmid-3128830
AB  - The Maternal and Child Health Information Network--MATCH--was begun in 1984 as a demonstration project with support from the Division of Maternal and Child Health of the Health Resources and Services Administration, Public Health Service. The primary purpose of the project was the development of a system to manage data related to prenatal, child health, family planning, and genetic services that are delivered with State support in clinics in the State of Ohio. The design of MATCH enables the same data base to be used at both the State and local levels. Because it allows all participants, central and district, to manipulate the raw data, it is called an end-user--as opposed to a batch retrieval--system. Data recorded on individual forms during each client's visit to local service clinics are collected and entered into a microcomputer whose software package is a commercial data base. The clinic can then use the data for its purposes: program planning, management, evaluation, client referrals, appointment followup, quality control, and billing. The same data are also uploaded by central office staff to the State's DEC mainframe from data-filled disks mailed in by the clinics. Personnel who staff local projects can access their own data on the mainframe computer to generate reports for local use and send and receive messages electronically. That is, the system is "interactive."(ABSTRACT TRUNCATED AT 250 WORDS)
JF  - Public Health Reports (Washington, D.C. : 1974)
AU  - Platt, L J
AU  - Benford, M S
AD  - Public Health Service Region IX, San Francisco, CA 94102.
PY  - 1988
SP  - 147
EP  - 153
VL  - 103
IS  - 2
SN  - 0033-3549, 0033-3549
KW  - Information Systems
KW  - Government Agencies
KW  - Computer User Training
KW  - Data Collection
KW  - Ohio
KW  - Computer Systems
KW  - Computer Communication Networks
KW  - Child Health Services
KW  - Maternal Health Services
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=MATCH%3A+a+maternal+and+child+health+information+network.&rft.au=Platt%2C+L+J%3BBenford%2C+M+S&rft.aulast=Platt&rft.aufirst=L&rft.date=1988-03-01&rft.volume=103&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/
LA  - eng
DB  - ComDisDome
N1  - Last updated - 2010-05-07
ER  - 



TY  - JOUR
T1  - FDA's Factored Food Vocabulary for food product description.
AN  - 85239550; pmid-3346493
AB  - The Food and Drug Administration's Factored Food Vocabulary (FFV) uses standardized language to describe characteristics of food products that are important for food safety and nutritional quality. Each food product is described by a set of descriptors from the following factors: product type; food source; part of plant or animal; physical state, shape, or form; degree of preparation; cooking method; treatment applied; preservation method; packing medium; container or wrapping; food contact surface; and user group. The purpose of the vocabulary is to facilitate retrieval of food composition, food consumption, food contamination, and other food-related data relative to these factors. The major advantages of this system are flexibility with specificity, enhanced searchability with economy, and ease of change and updating.
JF  - Journal of the American Dietetic Association
AU  - McCann, A
AU  - Pennington, J A
AU  - Smith, E C
AU  - Holden, J M
AU  - Soergel, D
AU  - Wiley, R C
AD  - Division of Information Resources Management, Food and Drug Administration, Washington, D.C.
PY  - 1988
SP  - 336
EP  - 341
VL  - 88
IS  - 3
SN  - 0002-8223, 0002-8223
KW  - United States
KW  - Subject Headings
KW  - Classification
KW  - United States Food and Drug Administration
KW  - Food
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LA  - eng
DB  - ComDisDome
N1  - Last updated - 2010-05-07
ER  - 



TY  - JOUR
T1  - Microsomal metabolism of 4-(N,N-diacetylamino)benzo[a]pyrene: a potent mutagenic arylamide derived from a carcinogenic polycyclic aromatic hydrocarbon.
AN  - 78813581; 2979718
AB  - 4-(N,N-Diacetylamino)benzo[a]pyrene, a potent mutagen, is derived from a carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene. Metabolism of this compound by rat liver microsomes was studied. Metabolites were separated by reversed-phase high-performance liquid chromatography and were identified by analysis of their UV-vis absorption, mass, and proton nuclear magnetic resonance spectral data. Seven metabolites were identified, namely, the 9-phenol, 1,9-hydroquinone, and trans-9,10-dihydrodiol of 4-(N,N-diacetylamino)benzo[a]pyrene, 4-(N-acetylamino)benzo[a]pyrene, and the 5-phenol, 5,9-hydroquinone, and trans-9,10-dihydrodiol of 4-(N-acetylamino)benzo[a]pyrene. Comparison of these results with those of metabolism of benzo[a]pyrene indicates that the N,N-diacetylamino substitutent at the 4-carbon of benzo[a]pyrene inhibits metabolism at the peri position (3-carbon) and positions (6-, 7-, and 8-carbons) remote from the substituent. The results also indicate that while 4-(N,N-diacetylamino)-benzo[a]pyrene is a substrate of the rat liver microsomal deacetylase, the formed 4-(N-acetylamino)benzo[a]pyrene apparently is not a substrate.
JF  - Chemical research in toxicology
AU  - Chou, M W
AU  - Miller, D W
AU  - Freeman, J P
AU  - Fu, P P
AD  - National Center for Toxicological Research, Jefferson, Arkansas 92079.
PY  - 1988
SP  - 115
EP  - 122
VL  - 1
IS  - 2
SN  - 0893-228X, 0893-228X
KW  - Benzopyrenes
KW  - 0
KW  - Carcinogens
KW  - Mutagens
KW  - Benzo(a)pyrene
KW  - 3417WMA06D
KW  - 4-N,N-diacetylaminobenzo(a)pyrene
KW  - 82507-24-2
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Molecular Structure
KW  - Mass Spectrometry
KW  - Animals
KW  - Biotransformation
KW  - Spectrophotometry
KW  - Male
KW  - Chromatography, High Pressure Liquid
KW  - Carcinogens -- metabolism
KW  - Microsomes, Liver -- metabolism
KW  - Benzopyrenes -- isolation & purification
KW  - Mutagens -- isolation & purification
KW  - Benzopyrenes -- metabolism
KW  - Benzo(a)pyrene -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1992-03-09
N1  - Date created - 1992-03-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Sampling and preparation of sample for chemical examination.
AN  - 78285360; 3384776
AB  - Sampling and methods for reducing a laboratory sample to a test sample are discussed, with particular emphasis on sampling peanuts for aflatoxin analysis as a practical example. The only way to control the total error in the analysis of this heterogeneous product is to take and to analyze many and large samples.
JF  - Journal - Association of Official Analytical Chemists
AU  - Horwitz, W
AD  - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204.
PY  - 1988
SP  - 241
EP  - 245
VL  - 71
IS  - 2
SN  - 0004-5756, 0004-5756
KW  - Aflatoxins
KW  - 0
KW  - Index Medicus
KW  - Aflatoxins -- analysis
KW  - Arachis -- analysis
KW  - Food Analysis
KW  - Chemistry Techniques, Analytical
KW  - Laboratories -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-29
N1  - Date created - 1988-07-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Levels and incidences of pesticide residues in various foods and animal feeds analyzed by the Luke multiresidue methodology for fiscal years 1982-1986.
AN  - 78281592; 3384794
AB  - During a 5 year period from 1982 to 1986, the FDA Los Angeles District Laboratory analyzed 19,851 samples of domestic and imported food and feed commodities for pesticide residues. A single, rapid, multiresidue method was used. The resultant data have been compiled showing the commodities sampled and the identity and range of levels of pesticide residues detected, including an indication of those residue findings that did not comply with U.S. federal tolerance levels. The residue data presented should not be viewed as being representative of the U.S. food supply; rather, the results are indicative of a surveillance- and compliance-oriented sampling of various food shipments collected by the Los Angeles District.
JF  - Journal - Association of Official Analytical Chemists
AU  - Luke, M A
AU  - Masumoto, H T
AU  - Cairns, T
AU  - Hundley, H K
AD  - Food and Drug Administration, Office of Regulatory Affairs, Los Angeles District Laboratory, CA 90015.
PY  - 1988
SP  - 415
EP  - 433
VL  - 71
IS  - 2
SN  - 0004-5756, 0004-5756
KW  - Dietary Fats
KW  - 0
KW  - Pesticide Residues
KW  - Index Medicus
KW  - United States
KW  - Dietary Fats -- analysis
KW  - United States Food and Drug Administration
KW  - Vegetables -- analysis
KW  - Legislation, Food
KW  - Edible Grain -- analysis
KW  - Food Analysis
KW  - Animal Feed -- analysis
KW  - Pesticide Residues -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-29
N1  - Date created - 1988-07-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - An overview of the Missouri dioxin studies.
AN  - 78253951; 3377552
AB  - Among the problems inherent in evaluating public health impacts around toxic waste sites are the difficulties in measuring exposure, our incomplete understanding of low-dose effects, the low frequency of disease incidence, the long latency period and silent course of disease development, the nonspecificity of clinical findings, and the probable multifactorial nature of diseases of interest. A multiphase approach for implementing epidemiologic studies in such settings was used in assessing the 2,3,7,8-tetrachlorodibenzodioxin (TCDD, or dioxin) contaminations in Missouri, where waste oil mixtures contaminated with dioxins were sprayed on various sites throughout the state for dust control in 1971. Although the toxic effects of dioxin have been studied extensively in animals and documented in cases of accidental high-level exposure in humans, very little is known of the human health effects, if any, produced by long-term exposure to relatively low levels of dioxin. In addition to medical epidemiologic studies, which were done to evaluate the types of problems present in groups of individuals with high-risk of environmental dioxin exposure, other studies to characterize dioxin levels in adipose tissue and serum are under way in a sample of potentially exposed (as well as in unexposed) Missouri residents. Research in these areas will continue to be pursued to develop a more complete understanding of the risks and appropriate public health interventions in situations of community exposure to environmental dioxins and other environmental contaminants.
JF  - Archives of environmental health
AU  - Stehr-Green, P A
AU  - Andrews, J S
AU  - Hoffman, R E
AU  - Webb, K B
AU  - Schramm, W F
AD  - Centers for Disease Control, Public Health Service, Atlanta, Georgia.
PY  - 1988
SP  - 174
EP  - 177
VL  - 43
IS  - 2
SN  - 0003-9896, 0003-9896
KW  - Dioxins
KW  - 0
KW  - Environmental Pollutants
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Adipose Tissue -- analysis
KW  - Risk Factors
KW  - Missouri
KW  - Humans
KW  - Time Factors
KW  - Dioxins -- poisoning
KW  - Dioxins -- analysis
KW  - Dioxins -- blood
KW  - Environmental Pollutants -- poisoning
KW  - Population Surveillance
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-01
N1  - Date created - 1988-07-01
N1  - Date revised - 2017-01-14
N1  - Last updated - 2017-01-19
ER  - 



TY  - JOUR
T1  - Exposure registries.
AN  - 78247233; 3288130
AB  - Exposure registries are new tools for use as part of the public health response to toxic occupational and environmental exposures. These registries can help fill a gap that currently exists in the effective handling of problems following the revelation of an exposure situation. In the past, such a tool was lacking and potentially high-risk groups may not have received needed services. Recent legislation, however, has mandated the establishment of exposure registries. These registries can help provide the basis for a unified response to what historically has been described as a fragmented and ineffective approach to managing high-risk cohorts and assessing the impact of toxic substances. Certain exposure registries are now mandated by law (PL 96-510), and they have a place alongside other disease control and public health tools. Their establishment and use is not without problems, but the gain from them could be substantial. They fill a gap in the current public health response to problems of groups found to be at increased risk of exposure to toxic substances.
JF  - Archives of environmental health
AU  - Schulte, P A
AU  - Kaye, W E
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
PY  - 1988
SP  - 155
EP  - 161
VL  - 43
IS  - 2
SN  - 0003-9896, 0003-9896
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Environmental Pollutants
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Risk
KW  - Humans
KW  - Legislation as Topic
KW  - Registries
KW  - Environmental Exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-01
N1  - Date created - 1988-07-01
N1  - Date revised - 2017-01-14
N1  - Last updated - 2017-01-19
ER  - 



TY  - JOUR
T1  - Microbial transformation of the antihistaminic drug triprolidine hydrochloride.
AN  - 78232403; 3286859
AB  - The production of a known mammalian metabolite of the antihistamine triprolidine through fungal metabolic transformation has been demonstrated. The filamentous fungus Cunninghamella elegans ATCC 9245 was grown in Sabouraud dextrose broth containing triprolidine hydrochloride monohydrate. One major metabolite was extracted with methylene chloride, isolated by high-performance liquid chromatography, and identified by its proton-nuclear magnetic resonance and desorption chemical ionization mass spectral properties as hydroxymethyl triprolidine (2-[1-(4-hydroxymethylphenyl)-3-(1-pyrrolidinyl-1-propenyl)] pyridine). After 240 h of incubation, the hydroxymethyl derivative represented approximately 55.0% of the initial dose. Fungal oxidation of hydroxymethyl triprolidine to the corresponding carboxylic acid triprolidine derivative (also a known mammalian triprolidine metabolite) was not observed. No mutagenic activity was observed for triprolidine and hydroxymethyl triprolidine by reversion of Salmonella typhimurium strains TA97, TA98, TA100, and TA104 at concentrations up to 1000 and 200 micrograms/plate, respectively. These results suggest that the fungal metabolism of triprolidine to the hydroxymethyl derivative occurs predominantly through pathways which do not result in mutagenic activation. Incubation of C. elegans with triprolidine under an 18O2 atmosphere and subsequent electron impact mass spectral analysis of the hydroxymethyl triprolidine formed indicate that molecular oxygen was incorporated into the methyl group and suggest a mono-oxygenase catalyzed reaction. This study parallels previous studies on the mammalian metabolism of triprolidine and clearly indicates that the microbial transformation of triprolidine is a useful alternative for the synthesis of potential mammalian metabolites.
JF  - Journal of pharmaceutical sciences
AU  - Hansen, E B
AU  - Heflich, R H
AU  - Korfmacher, W A
AU  - Miller, D W
AU  - Cerniglia, C E
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/03//
PY  - 1988
DA  - March 1988
SP  - 259
EP  - 264
VL  - 77
IS  - 3
SN  - 0022-3549, 0022-3549
KW  - Mutagens
KW  - 0
KW  - Oxygen Isotopes
KW  - Pyridines
KW  - Triprolidine
KW  - 2L8T9S52QM
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Oxygen Consumption -- drug effects
KW  - Mutagenicity Tests
KW  - Biotransformation
KW  - In Vitro Techniques
KW  - Salmonella typhimurium -- drug effects
KW  - Salmonella typhimurium -- genetics
KW  - Chromatography, High Pressure Liquid
KW  - Triprolidine -- isolation & purification
KW  - Mucorales -- metabolism
KW  - Triprolidine -- toxicity
KW  - Triprolidine -- metabolism
KW  - Pyridines -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-28
N1  - Date created - 1988-06-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Morphological transformation of BALB/3T3 mouse embryo cells in vitro by vomitoxin.
AN  - 78203708; 3366424
AB  - The transforming potential of vomitoxin, a trichothecene mycotoxin produced on cereal grains by fungi of the genus Fusarium, was assessed using mouse embryo BALB/3T3 A31-1-1 cells. Cells grown in Eagle's basal medium with Earle's salts supplemented with 7.5% foetal bovine serum were treated with highly purified vomitoxin, which was dissolved in distilled water and filter-sterilized. Assays were conducted using cells from three different passages at dose levels ranging from 0.1 to 1.6 microgram/ml. The treatment time was 48 hr and the highest dose levels tested produced approximately 10% survival as determined by in situ cell counts. Distilled water and 3-methylcholanthrene (5.0 micrograms/ml) were used as the vehicle and positive controls, respectively. Of the 20 dishes examined per dose group, the numbers of type III foci were 0-1 in the solvent control, 12-15 in the positive control and 0-9 in the treated groups. Comparison of the three assays showed that the level of response varied with passage number. Of the three passages of cells tested-passage numbers 6, 8 and 9 (p6, p8 and p9)--passage-9 cells produced the strongest positive effect.
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Sheu, C W
AU  - Moreland, F M
AU  - Lee, J K
AU  - Dunkel, V C
AD  - Division of Toxicology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/03//
PY  - 1988
DA  - March 1988
SP  - 243
EP  - 245
VL  - 26
IS  - 3
SN  - 0278-6915, 0278-6915
KW  - Sesquiterpenes
KW  - 0
KW  - Trichothecenes
KW  - deoxynivalenol
KW  - JT37HYP23V
KW  - Index Medicus
KW  - Animals
KW  - Mutagenicity Tests
KW  - Cell Survival -- drug effects
KW  - Cell Line
KW  - Trichothecenes -- toxicity
KW  - Cell Transformation, Neoplastic -- chemically induced
KW  - Sesquiterpenes -- toxicity
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Morphological+transformation+of+BALB%2F3T3+mouse+embryo+cells+in+vitro+by+vomitoxin.&rft.au=Sheu%2C+C+W%3BMoreland%2C+F+M%3BLee%2C+J+K%3BDunkel%2C+V+C&rft.aulast=Sheu&rft.aufirst=C&rft.date=1988-03-01&rft.volume=26&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-21
N1  - Date created - 1988-06-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Teratogenicity of n-propanol and isopropanol administered at high inhalation concentrations to rats.
AN  - 78202889; 3366425
AB  - As part of a teratological evaluation of several alcohols, 10,000, 7000 and 3500 ppm n-propanol or isopropanol were administered by inhalation to groups of 15 pregnant Sprague-Dawley rats for 7 hr/day on gestation days 1-19. The dams were killed on day 20. Half of the foetuses were examined for skeletal defects and the others for visceral defects using the Wilson technique. The highest concentration of n-propanol produced only minimal maternal toxicity, as indicated by observation and by measurement of weight gain and feed and water intake. In contrast, the same concentration of isopropanol produced narcosis in the dams, retarded body-weight gain and reduced the feed intake. At 7000 ppm isopropanol, body-weight gain was retarded but there were no other observable effects in the dams. Following exposure to 10,000 ppm of either alcohol, there were significant (P less than or equal to 0.05) increases in resorptions and decreases in foetal weights compared with the control groups. Foetal weights were also reduced significantly following exposure to 7000 ppm of either alcohol and to 3500 ppm isopropanol. Significantly more litters had malformations following exposure to 10,000 or 7000 ppm of either alcohol, but these effects were seen only in the presence of maternal toxicity. At 3500 ppm, no detectable teratogenic effects were produced by either solvent.
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Nelson, B K
AU  - Brightwell, W S
AU  - MacKenzie-Taylor, D R
AU  - Khan, A
AU  - Burg, J R
AU  - Weigel, W W
AU  - Goad, P T
AD  - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1988/03//
PY  - 1988
DA  - March 1988
SP  - 247
EP  - 254
VL  - 26
IS  - 3
SN  - 0278-6915, 0278-6915
KW  - Teratogens
KW  - 0
KW  - 1-Propanol
KW  - 96F264O9SV
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Viscera -- abnormalities
KW  - Dose-Response Relationship, Drug
KW  - Bone and Bones -- abnormalities
KW  - Administration, Inhalation
KW  - Female
KW  - Pregnancy
KW  - 1-Propanol -- toxicity
KW  - 1-Propanol -- blood
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-21
N1  - Date created - 1988-06-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Suicide among social workers in Rhode Island.
AN  - 78172081; 3361358
AB  - Cause-specific mortality patterns, by occupation, were examined among Rhode Island residents who died during the period 1968-1978, using the age-standardized proportionate mortality ratio (PMR) method. Occupation was determined from the usual occupation statement on the death certificate. A noteworthy finding was an elevated PMR for suicide among both male (PMR = 470, observed deaths = 5, P less than .01) and female (PMR = 510, observed deaths = 4, P less than .05) social workers. This is the first report of a high risk of suicide among social workers. Stress, which is associated with social work, may be a risk factor. Due to the relatively small numbers upon which this report is based and the limitations of death certificate data and the PMR method, this should be viewed as an exploratory investigation requiring further follow-up.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Dubrow, R
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH.
Y1  - 1988/03//
PY  - 1988
DA  - March 1988
SP  - 211
EP  - 213
VL  - 30
IS  - 3
SN  - 0096-1736, 0096-1736
KW  - Index Medicus
KW  - Burnout, Professional -- complications
KW  - Rhode Island
KW  - Risk Factors
KW  - Humans
KW  - Adult
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Social Work
KW  - Suicide -- epidemiology
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-02
N1  - Date created - 1988-06-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction.
AN  - 78125769; 3345577
AB  - 1-Nitropyrene, the predominant nitropolycyclic aromatic hydrocarbon found in diesel exhaust, is a mutagen and tumorigen. 1,6-Dinitropyrene is present in diesel exhaust in much smaller quantities than 1-nitropyrene, but is much more mutagenic and carcinogenic. In an attempt to understand this difference in biological potencies, we have compared the extent of DNA binding by these two nitropyrenes in vivo. We have also determined the effect of 1-nitropyrene pretreatment upon the induction of nitroreductases and the subsequent DNA binding by both 1-nitropyrene and 1,6-dinitropyrene. Covalent DNA binding by 1-nitropyrene could not be detected in vivo; however, 1,6-dinitropyrene formed N-(deoxyguanosin-8-yl)-1-amino-6-nitropyrene as the major DNA adduct in rat liver, kidney, urinary bladder and mammary gland, with the highest levels being found in the bladder. The capability of liver microsomes to catalyze the oxidative metabolism of 1-nitropyrene was unchanged after treating rats with 8 mg/kg 1-nitropyrene. Cytochrome P-450, NADPH-cytochrome P-450 reductase and cytochrome b5 levels were also unchanged, while slight increases were detected in NADH-cytochrome b5 reductase and epoxide hydrase activities. Liver cytosolic and microsomal nitroreductase activities toward both 1-nitropyrene and 1,6-dinitropyrene were increased 2-fold, and cytosolic nitrosoreductase activity toward 1-nitrosopyrene and 1-nitro-6-nitrosopyrene was elevated by approximately 20%. DNA binding of both 1-nitropyrene and 1,6-dinitropyrene in vitro was 2-fold higher when using cytosol from 1-nitropyrene-pretreated rats. However, pretreatment of rats with 1-nitropyrene only slightly increased the amount of in vivo DNA binding by 1,6-dinitropyrene except in kidney where there was a 60% increase. These results indicate that although nitroreduction is involved in DNA adduct formation by 1,6-dinitropyrene, additional factors (e.g. O-acetylation) limit the extent of DNA binding in vivo.
JF  - Carcinogenesis
AU  - Djurić, Z
AU  - Fifer, E K
AU  - Yamazoe, Y
AU  - Beland, F A
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988/03//
PY  - 1988
DA  - March 1988
SP  - 357
EP  - 364
VL  - 9
IS  - 3
SN  - 0143-3334, 0143-3334
KW  - Mutagens
KW  - 0
KW  - Pyrenes
KW  - 1,6-dinitropyrene
KW  - 66Q2ZUF83N
KW  - DNA
KW  - 9007-49-2
KW  - Oxidoreductases
KW  - EC 1.-
KW  - Nitroreductases
KW  - EC 1.7.-
KW  - 1-nitropyrene
KW  - TD1665I8Q4
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Enzyme Induction -- drug effects
KW  - Cytosol -- enzymology
KW  - Microsomes, Liver -- enzymology
KW  - Male
KW  - Nitroreductases -- biosynthesis
KW  - Mutagens -- metabolism
KW  - DNA -- metabolism
KW  - Pyrenes -- metabolism
KW  - Oxidoreductases -- biosynthesis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-14
N1  - Date created - 1988-04-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - RPRT
T1  - Report to the Congress on Nursing and Other Nonphysician Health Professions Educational Programs Reimbursed under Medicare.
AN  - 63117101; ED303690
AB  - This report provides information on approved educational activities for nursing and other nonphysician health professions for which reimbursement is made to hospitals under the Medicare program. Information was summarized from an examination of existing data and a special study of the variations that exist in hospital educational activities. The report provides interpreted statistics on the following: types and numbers of educational programs; numbers of students supported or trained; fiscal and administrative relationships between the hospitals and affiliated schools; financial and other benefits that accrue to the hospitals as a consequence of having such programs; and the types of educational expenses that are being reimbursed. The report contains a brief summary of selected regulations and judicial decisions to show changes that have occurred in Medicare reimbursement for the cost of approved educational activities from Medicare's inception in 1965 to the present. The report reviews reimbursement of jointly operated educational programs. Detailed summaries of survey results by discipline are given. (KC)
Y1  - 1988/03//
PY  - 1988
DA  - March 1988
SP  - 78
PB  - U.S. Department of Commerce, National Technical Information Service (NTIS), 5285 Port Royal Rd., Springfield, VA 22161.
VL  - HRP-0907201
KW  - Medicare
KW  - ERIC, Resources in Education (RIE)
KW  - Program Effectiveness
KW  - Postsecondary Education
KW  - Allied Health Occupations Education
KW  - Program Administration
KW  - Nursing Education
KW  - Federal Programs
KW  - Educational Finance
KW  - Program Costs
KW  - Outcomes of Education
KW  - Hospitals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63117101?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - Appendix C contains marginally legible print.
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - The importance of adverse reaction reporting by physicians. Suprofen and the flank pain syndrome.
AN  - 78101651; 3276945
AB  - The role of spontaneous reporting in detecting the suprofen-associated flank pain syndrome was examined, including the specific effect of the "Dear Doctor" letter in accelerating the information-gathering process once the initial signal was generated. We believe this to be a noteworthy example of the ability of spontaneous reporting to produce a timely and unequivocal signal of drug-related risk. It also serves to demonstrate the need for vigilant postmarketing surveillance for all newly marketed drugs in the United States, even though considerable premarketing and postmarketing drug experience may exist from use in countries outside of the United States.
JF  - JAMA
AU  - Rossi, A C
AU  - Bosco, L
AU  - Faich, G A
AU  - Tanner, A
AU  - Temple, R
AD  - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD 20857.
Y1  - 1988/02/26/
PY  - 1988
DA  - 1988 Feb 26
SP  - 1203
EP  - 1204
VL  - 259
IS  - 8
SN  - 0098-7484, 0098-7484
KW  - Phenylpropionates
KW  - 0
KW  - Suprofen
KW  - 988GU2F9PE
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Drug Industry
KW  - United States Food and Drug Administration
KW  - Syndrome
KW  - Humans
KW  - Product Surveillance, Postmarketing
KW  - Clinical Trials as Topic
KW  - Europe
KW  - Phenylpropionates -- adverse effects
KW  - Suprofen -- adverse effects
KW  - Data Collection -- methods
KW  - Pain -- chemically induced
KW  - Acute Kidney Injury -- chemically induced
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=The+importance+of+adverse+reaction+reporting+by+physicians.+Suprofen+and+the+flank+pain+syndrome.&rft.au=Rossi%2C+A+C%3BBosco%2C+L%3BFaich%2C+G+A%3BTanner%2C+A%3BTemple%2C+R&rft.aulast=Rossi&rft.aufirst=A&rft.date=1988-02-26&rft.volume=259&rft.issue=8&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-11
N1  - Date created - 1988-03-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Magnetic resonance imaging: a noninvasive tool for fetal and placental physiology.
AN  - 78194962; 3284598
AB  - Nuclear magnetic resonance imaging (MRI), a technique that utilizes biochemical information reflected in nuclear magnetic moments, can be used to image the uterus, fetus, and placenta of the human and nonhuman primate. MRI studies during pregnancy in the human and nonhuman primate provide soft-tissue structural information of considerable detail. MRI also offers the opportunity for noninvasive pharmacokinetic and toxicokinetic studies during pregnancy. Paramagnetic ions (Cu, Ni, Gd, Fe, Mn) after spin-lattice (T1) and spin-spin (T2) relaxation times in reproductive tissues. Changes in T1 and T2 alter the MRI image, reflecting uptake of paramagnetic ions by the uterus, placenta, or fetus. MRI provides a noninvasive method of monitoring body burden of selected xenobiotics during gestation. The use of paramagnetic labels on endogenous substances may also allow noninvasive determination of physiological parameters such as intervillous blood flow, placental metabolism, and placental transport during gestation.
JF  - Biology of reproduction
AU  - Mattison, D R
AU  - Kay, H H
AU  - Miller, R K
AU  - Angtuaco, T
AD  - Human Risk Assessment Program, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 39
EP  - 49
VL  - 38
IS  - 1
SN  - 0006-3363, 0006-3363
KW  - Index Medicus
KW  - Animals
KW  - Macaca fascicularis
KW  - Humans
KW  - Female
KW  - Pregnancy
KW  - Magnetic Resonance Imaging
KW  - Fetus -- physiology
KW  - Placenta -- physiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-20
N1  - Date created - 1988-06-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Subchronic studies of doxylamine in B6C3F1 mice.
AN  - 78164700; 3356311
AB  - Doxylamine succinate, a histamine (H1) antagonist (antihistamine), was administered as an admixture in the feed to male and female B6C3F1 mice for 14 or 90 days. Dose levels of 0, 100, 250, 500, 1000, and 2000 ppm doxylamine were administered to males and females in the 14-day study while dose levels of 0, 80, 162, 325, 750, and 1500 ppm were administered to both sexes in the 90-day study. Little toxicity was seen in the 14-day study. Final body weights in the highest dose group were reduced 4.0 and 7.3% in males and females, respectively. Treatment-related histopathological changes in the 14-day study were limited to a very low incidence of hepatic necrosis in both sexes. There was little toxicity observed in the 90-day study and no clear dose response relative to weight gain was observed. Histologically, the liver was the only organ affected by doxylamine administration. The liver lesions consisted of hepatic cell cytomegaly and/or karyomegaly which varied from mild to severe and a possible dose-related hepatic necrosis.
JF  - Fundamental and applied toxicology : official journal of the Society of Toxicology
AU  - Jackson, C D
AU  - Blackwell, B N
AD  - Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 254
EP  - 261
VL  - 10
IS  - 2
SN  - 0272-0590, 0272-0590
KW  - Pyridines
KW  - 0
KW  - Doxylamine
KW  - 95QB77JKPL
KW  - Index Medicus
KW  - Eating -- drug effects
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Body Weight -- drug effects
KW  - Mice
KW  - Male
KW  - Female
KW  - Organ Size -- drug effects
KW  - Doxylamine -- toxicity
KW  - Pyridines -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-13
N1  - Date created - 1988-05-13
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Subchronic studies of doxylamine in Fischer 344 rats.
AN  - 78161815; 3356310
AB  - Doxylamine succinate was administered as an admixture in the feed to male and female Fischer 344 rats for either 14 or 90 days. The 14-day study included dose levels of 0, 100, 250, 500, 1000, or 2000 ppm doxylamine. Except for a 7% decrease in final body weight in female rats in the 2000 ppm group, there were no significant clinical observations made in the 14-day study. Microscopic lesions judged to be treatment-related were limited to cytoplasmic vacuolization in the livers. The lesions were more numerous in the higher dose groups of males and present only in the 2000 ppm group of females. Dose levels of 0, 162, 405, 1012, 2530, and 6325 ppm doxylamine were administered in the 90-day study. There were no deaths during the study. Final body weights were decreased 13.3% in males of the 6325 ppm group and 5.2, 10.1, and 14.4% in females in the 1012, 2530, and 6325 ppm groups, respectively. Liver/brain weight ratios were increased in all treated male groups and in the two highest dose groups of females. Other organ weight changes were decreases and believed to result from general reduction in weight gain in those groups where the decreases occurred. Treatment-related histological changes were identified in the liver and parotid salivary gland. Cytoplasmic vacuolization or fatty change of the liver was found in all groups of males but was more severe in the higher dose groups. In females, these liver lesions were observed only in the two highest dose groups. A dose-related change in the parotid salivary gland, consisting of cytomegaly with basophilic and coarsely granular or vacuolated cytoplasm, was observed.
JF  - Fundamental and applied toxicology : official journal of the Society of Toxicology
AU  - Jackson, C D
AU  - Blackwell, B N
AD  - Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 243
EP  - 253
VL  - 10
IS  - 2
SN  - 0272-0590, 0272-0590
KW  - Pyridines
KW  - 0
KW  - Doxylamine
KW  - 95QB77JKPL
KW  - Index Medicus
KW  - Rats
KW  - Eating -- drug effects
KW  - Animals
KW  - Rats, Inbred F344
KW  - Liver -- pathology
KW  - Fatty Liver -- chemically induced
KW  - Body Weight -- drug effects
KW  - Fatty Liver -- pathology
KW  - Male
KW  - Female
KW  - Organ Size -- drug effects
KW  - Doxylamine -- toxicity
KW  - Pyridines -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-13
N1  - Date created - 1988-05-13
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Enhancement of estradiol potency by the 17 beta-hydroxysteroid dehydrogenase inhibitor, 16-methylene E2 in vivo.
AN  - 78140573; 2831339
AB  - The ability of 16-methylene E2, a 17 beta-hydroxysteroid dehydrogenase inhibitor, to enhance estradiol 17 beta (E2) potency was assayed by 24-hr weight gain in the immature rat uterus. Initial studies demonstrated that 16-methylene E2 (1-100 micrograms s.c.) did not produce significant uterine weight gain 24 hr after administration, whereas E2 (0.1-10 micrograms s.c.) produced a significant uterine weight gain under the same experimental conditions. A subthreshold dose of E2 (0.01 microgram s.c.) when administered in combination with 100 micrograms (s.c.) of 16-methylene E2 produced a significant uterine weight gain. When rats were predosed with 16-methylene E2 at 72, 48, 24, 6 or 0 hr before the administration of 0.01 microgram of E2, the magnitude of the 24-hr uterine weight gain increased and attained maximal values for the 6-hr pretreatment time point. A subsequent dose-response study of 16-methylene E2 (1-100 micrograms s.c.) administered 6 hr before 0.01 microgram of E2 revealed that the 10, 50 and 100 microgram 16-methylene E2 dose significantly increased uterine weight gain in a dose-dependent manner. These results indicate that 16-methylene E2 is not a direct acting estrogen but acts synergistically with E2 to produce an enhanced uterine response. In a separate set of monkey experiments: 1) A trace dose of [3H]E2 was perfused through the in situ, term rhesus monkey placenta via the umbilical arteries and samples were collected from the umbilical vein of this open system.(ABSTRACT TRUNCATED AT 250 WORDS)
JF  - The Journal of pharmacology and experimental therapeutics
AU  - McDonald, Z A
AU  - Slikker, W
AU  - Fu, P P
AU  - Bailey, J R
AU  - Lipe, G W
AU  - Unruh, L E
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 428
EP  - 431
VL  - 244
IS  - 2
SN  - 0022-3565, 0022-3565
KW  - Estradiol
KW  - 4TI98Z838E
KW  - 16-methylene estradiol
KW  - 7627-87-4
KW  - 17-Hydroxysteroid Dehydrogenases
KW  - EC 1.1.-
KW  - 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))
KW  - EC 1.1.1.239
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Macaca mulatta
KW  - Drug Synergism
KW  - Uterus -- drug effects
KW  - Female
KW  - Pregnancy
KW  - Estradiol -- analogs & derivatives
KW  - Estradiol -- pharmacology
KW  - Estradiol -- metabolism
KW  - 17-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-12
N1  - Date created - 1988-04-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neurobehavioral effects of solvents in construction painters.
AN  - 78139848; 3351646
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Baker, E L
AU  - Letz, R E
AU  - Eisen, E A
AU  - Pothier, L J
AU  - Plantamura, D L
AU  - Larson, M
AU  - Wolford, R
AD  - National Institute for Occupational Safety and Health, Atlanta, GA 30333.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 116
EP  - 123
VL  - 30
IS  - 2
SN  - 0096-1736, 0096-1736
KW  - Solvents
KW  - 0
KW  - Index Medicus
KW  - Affect -- drug effects
KW  - Psychomotor Performance -- drug effects
KW  - Humans
KW  - Paint
KW  - Adult
KW  - Neuropsychological Tests
KW  - Time Factors
KW  - Male
KW  - Solvents -- adverse effects
KW  - Nervous System Diseases -- chemically induced
KW  - Occupational Diseases -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-29
N1  - Date created - 1988-04-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - In vivo and in vivo/in vitro kinetics of cyclophosphamide-induced sister-chromatid exchanges in mouse bone marrow and spleen cells.
AN  - 78120647; 3343979
AB  - In several acute and chronic exposures to various chemicals in vivo and in vitro, the average sister-chromatid exchange (SCE) frequencies in human, mouse, rat, and rabbit lymphocytes generally decrease with time following treatment. The rate of this decline varies, but little data have been published pertaining to the comparative kinetics of SCEs both in vivo and in vivo/in vitro (exposure of animals to the test compound and culturing of cells) simultaneously in the same tissues. In this study, a single dose of cyclophosphamide (40 mg/kg) was injected for varying periods (6-48 h) and its effects, as assessed by the induction of SCEs, were analyzed under both in vivo and in vivo/in vitro conditions in mouse bone marrow and spleen cells. In vivo, the cyclophosphamide-induced SCEs increased with increasing time up to 12 h, stayed at approximately the same level until 24 h, and then decreased with increase in post-exposure time. However, the SCE levels remained significantly higher than controls at 48 h post-exposure time in both bone marrow and spleen cells. Under in vivo/in vitro conditions, the SCEs in bone marrow decreased with increase in post-exposure time until reaching control values by 48 h post exposure. However, in spleen cells, the decrease in SCE level was gradual, and by 48 h post-exposure time, the cells still had approximately 6 times higher SCEs than the control values. These results suggest that there are pharmacokinetic differences for cyclophosphamide in mouse bone marrow and spleen. Also, there is a differential SCE response to cyclophosphamide under in vivo and in vivo/in vitro conditions.
JF  - Mutation research
AU  - Krishna, G
AU  - Nath, J
AU  - Petersen, M
AU  - Ong, T
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 297
EP  - 305
VL  - 204
IS  - 2
SN  - 0027-5107, 0027-5107
KW  - Cyclophosphamide
KW  - 8N3DW7272P
KW  - Index Medicus
KW  - Bone Marrow Cells
KW  - Animals
KW  - Cells, Cultured
KW  - Mice
KW  - Time Factors
KW  - Male
KW  - Spleen -- cytology
KW  - Sister Chromatid Exchange -- drug effects
KW  - Spleen -- drug effects
KW  - Cyclophosphamide -- pharmacokinetics
KW  - Bone Marrow -- drug effects
KW  - Cyclophosphamide -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-29
N1  - Date created - 1988-03-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Gynecomastia associated with calcium channel blocker therapy.
AN  - 78096098; 3341839
AB  - Gynecomastia is a reaction that is not usually associated with calcium channel blocker therapy. The Division of Epidemiology and Surveillance, within the US Food and Drug Administration (Rockville, Md), has received 31 reports of gynecomastia occurring after the use of these drugs. The underlying mechanism of this reaction is unknown, although two patients did report elevated prolactin levels. Gynecomastia developed in two patients, resulting in the surgical removal of the breast and/or nodules before discontinuation of drug therapy. The possibility of an association between calcium channel blockers and gynecomastia should be considered before an extensive workup or surgical procedure is undertaken.
JF  - Archives of internal medicine
AU  - Tanner, L A
AU  - Bosco, L A
AD  - Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Md.
Y1  - 1988/02//
PY  - 1988
DA  - February 1988
SP  - 379
EP  - 380
VL  - 148
IS  - 2
SN  - 0003-9926, 0003-9926
KW  - Calcium Channel Blockers
KW  - 0
KW  - Verapamil
KW  - CJ0O37KU29
KW  - Diltiazem
KW  - EE92BBP03H
KW  - Nifedipine
KW  - I9ZF7L6G2L
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Drug Administration Schedule
KW  - Nifedipine -- administration & dosage
KW  - Verapamil -- adverse effects
KW  - Humans
KW  - Nifedipine -- adverse effects
KW  - Aged
KW  - Recurrence
KW  - Diltiazem -- adverse effects
KW  - Diltiazem -- administration & dosage
KW  - Verapamil -- administration & dosage
KW  - Product Surveillance, Postmarketing
KW  - Middle Aged
KW  - Time Factors
KW  - Male
KW  - Calcium Channel Blockers -- adverse effects
KW  - Gynecomastia -- chemically induced
KW  - Calcium Channel Blockers -- administration & dosage
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-08
N1  - Date created - 1988-03-08
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
Arch Intern Med. 1994 Feb 14;154(3):351 [8297206]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Food and Drug Administration guidelines for reproductive toxicity testing.
AN  - 78821116; 2980359
AB  - The Food and Drug Administration generally requires reproductive toxicity testing of all new drugs to be used by pregnant women or women or men of reproductive potential. These requirements may vary among the centers within the FDA. Reproductive and developmental toxicity is usually tested in one or two animal species and is divided into three segments to represent treatment throughout the reproductive process. The FDA monitors adverse drug effects on human reproduction through postmarketing surveillance.
JF  - Reproductive toxicology (Elmsford, N.Y.)
AU  - Raheja, K L
AU  - Jordan, A
AU  - Fourcroy, J L
AD  - Division of Metabolism and Endocrine Drug Products, Food and Drug Administration, Rockville, MD 20857.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 291
EP  - 293
VL  - 2
IS  - 3-4
SN  - 0890-6238, 0890-6238
KW  - Drugs, Investigational
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - Drug Evaluation
KW  - Humans
KW  - Clinical Trials as Topic
KW  - Male
KW  - Female
KW  - Pregnancy
KW  - United States Food and Drug Administration
KW  - Reproduction -- drug effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78821116?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Food+and+Drug+Administration+guidelines+for+reproductive+toxicity+testing.&rft.au=Raheja%2C+K+L%3BJordan%2C+A%3BFourcroy%2C+J+L&rft.aulast=Raheja&rft.aufirst=K&rft.date=1988-01-01&rft.volume=2&rft.issue=3-4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1992-05-07
N1  - Date created - 1992-05-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The effects of ethylene dibromide on semen quality: a comparison of short-term and chronic exposure.
AN  - 78809776; 2980345
AB  - Two occupational field studies were conducted to determine the effects of ethylene dibromide (EDB) exposure on male reproductive potential. The first study was a longitudinal study of 10 EDB-exposed forestry employees and 6 unexposed men conducted in Colorado in the summer of 1983. The exposure time was approximately 6 weeks. The second study was a cross-sectional study of 46 EDB-exposed papaya workers and 43 unexposed men conducted in Hawaii in December 1983 in which the average term of employment was about 5 years. In the longitudinal study, sperm velocity decreased in all 10 exposed men and in only two unexposed men. Semen volume was also decreased in 9 of the 10 exposed men (there was no change in the other man); only two unexposed men had a decrease in their semen volume. The longer term EDB exposure resulted in decreases in sperm motility and viability, suggesting that the short term exposure may slow sperm velocity, but longer exposures cause immotility and cell death. An apparent decrease in semen volume that was observed in the longitudinal study was not statistically significant in the cross sectional study of workers having chronic exposure. However, a significantly higher semen pH was observed in the exposed men compared to the unexposed men in the cross-sectional study. The results from both studies suggest that the accessory sex glands may be affected by EDB exposure.
JF  - Reproductive toxicology (Elmsford, N.Y.)
AU  - Schrader, S M
AU  - Turner, T W
AU  - Ratcliffe, J M
AD  - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 191
EP  - 198
VL  - 2
IS  - 3-4
SN  - 0890-6238, 0890-6238
KW  - Ethylene Dibromide
KW  - 1N41638RNO
KW  - Index Medicus
KW  - Cross-Sectional Studies
KW  - Cell Survival -- drug effects
KW  - Hydrogen-Ion Concentration
KW  - Humans
KW  - Surveys and Questionnaires
KW  - Sperm Motility -- drug effects
KW  - Longitudinal Studies
KW  - Time Factors
KW  - Male
KW  - Occupational Exposure
KW  - Ethylene Dibromide -- adverse effects
KW  - Semen -- chemistry
KW  - Semen -- cytology
KW  - Semen -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1992-05-07
N1  - Date created - 1992-05-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - NIOSH selection of chemicals and study publications: setting priorities for reproductive research.
AN  - 78808395; 2980358
AB  - The National Institute for Occupational Safety and Health (NIOSH) prioritizes topics for reproductive research in order to allocate limited resources to the most important issues. In the past, we have relied on an informal network including our own project officers, toxicologists, and the public to nominate chemicals to study. Setting priorities has consisted of the evaluation of research ideas by criteria such as the chemical's probable toxicity and the extent of exposure to the chemical in the workplace. NIOSH researchers are developing a system for evaluating large databases of toxicologic and occupational exposure information to identify potential reproductive toxins. When this system is operational it will provide a systematic way to nominate chemicals for study.
JF  - Reproductive toxicology (Elmsford, N.Y.)
AU  - Wells, V E
AU  - Schnorr, T M
AU  - Halperin, W E
AD  - NIOSH Division of Surveillance, Hazard Evaluations, and Field Studies Industrywide Studies Branch, Cincinnati, Ohio 45226.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 289
EP  - 290
VL  - 2
IS  - 3-4
SN  - 0890-6238, 0890-6238
KW  - Hazardous Substances
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - Occupational Exposure
KW  - Research
KW  - Reproduction -- drug effects
KW  - Government Publications as Topic
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Hazardous Substances -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1992-05-07
N1  - Date created - 1992-05-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The effect of food on the absorption of controlled-release theophylline in mini-swine.
AN  - 78750931; 3244609
AB  - The effect of differing fat contents of food on the bioavailability of theophylline following a 400-mg single dose of Theo-24 was studied in mini-swine. The pharmacokinetics of theophylline, following the intravenous administration of aminophylline equivalent to 5 mg/kg as a single dose, were also studied in the same animals. The terminal plasma half-life of theophylline following an i.v. dose was found to be approximately 24 hr. The volume of distribution, Vdext, and clearance following the i.v. dose were approximately 0.7 liter/kg and 0.023 liter/hr/kg, respectively. The terminal half-life of theophylline following the administration of theophylline capsules under fasting conditions was 21 hr. The average bioavailability under fasting conditions was approximately 80% compared to the i.v. dose. Food appeared to have decreased the rate of absorption but no significant effect on the extent of absorption.
JF  - Pharmaceutical research
AU  - Shiu, G K
AU  - Sager, A O
AU  - Velagapudi, R B
AU  - Prasad, V K
AU  - Skelly, J P
AD  - Biopharmaceutics Research Branch, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 48
EP  - 52
VL  - 5
IS  - 1
SN  - 0724-8741, 0724-8741
KW  - Delayed-Action Preparations
KW  - 0
KW  - Aminophylline
KW  - 27Y3KJK423
KW  - Theophylline
KW  - C137DTR5RG
KW  - Index Medicus
KW  - Swine
KW  - Animals
KW  - Aminophylline -- administration & dosage
KW  - Drug Interactions
KW  - Aminophylline -- pharmacokinetics
KW  - Injections, Intravenous
KW  - Fasting
KW  - Swine, Miniature
KW  - Biological Availability
KW  - Food
KW  - Theophylline -- pharmacokinetics
KW  - Theophylline -- administration & dosage
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-06-05
N1  - Date created - 1989-06-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Distribution of lost-work-time claims for skin disease in California agriculture: 1978-1983.
AN  - 78701827; 2976577
AB  - In order to identify California agricultural workers at high risk for occupational skin disease, we evaluated the distribution of 2,722 claims for lost-work-time skin conditions reported between 1978 and 1983 by Standard Industrial Classification (SIC) and source of illness. In the overall work force, cases were most frequently attributed to plants (52.1%), chemical exposures (20.4%), and food products (12.5%), but considerable variation occurred in the distribution of cases among the subdivisions of agriculture. The forestry subdivisions (SICs 081, 082, 084, and 085) had the highest rate (given as cases/10,000 employed) of claims for skin disease attributed to plants (53.5), but no cases due to other exposures. For chemical exposures, the highest rate of claims occurred in the horticultural specialities (SIC 018) subdivision (5.1), but this group also had a significant claims rate for plant-related skin disease (15.9). The highest claims rate for cases attributed to food products occurred in the vegetables/melons subdivision (4.7), but this group had claims rates for exposure to plants (3.8) and chemicals (2.8) that were nearly as high. Efforts to evaluate and prevent skin disease in agricultural workers should recognize the complex range of exposures to which this work force is subject.
JF  - American journal of industrial medicine
AU  - O'Malley, M A
AU  - Mathias, C G
AD  - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 715
EP  - 720
VL  - 14
IS  - 6
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - California
KW  - Humans
KW  - Agricultural Workers' Diseases -- epidemiology
KW  - Workers' Compensation
KW  - Dermatitis, Occupational -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-04-14
N1  - Date created - 1989-04-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+.
AN  - 78693822; 3266233
AB  - Unilateral intranigral administration of the oxidative metabolites of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenyl-dihydropyridine (MPDP+) or 1-methyl-4-phenylpyridine (MPP+) produced dose-dependently a depletion of dopamine in the ipsilateral striatum of rats two weeks following treatment. d-Amphetamine and apomorphine induced circling toward the lesioned side in these unilaterally treated animals. No contralateral circling behavior was observed after challenging with apomorphine. This dopamine lesioning effect of MPP+ was not blocked by pretreatment of animals with a dopamine uptake blocker, GBR 12909. Furthermore, MPP+ increased the 45Ca accumulation into cells at the site of injection and produced "nonspecific" cell membrane and/or cytotoxic damage seen by histological procedures. These results indicate that MPDP+ and MPP+ produced localized cytotoxic damage to nigrostriatal neurons, caused a decrease in striatal dopamine, and disrupted the nigrostriatal system's functioning following intranigral administration to rats. It is postulated that the cationic surfactant properties of MPDP+ and MPP+ might contribute to its neurotoxic effects.
JF  - Journal of neural transmission
AU  - Sun, C J
AU  - Johannessen, J N
AU  - Gessner, W
AU  - Namura, I
AU  - Singhaniyom, W
AU  - Brossi, A
AU  - Chiueh, C C
AD  - Food and Drug Administration, Bethesda, Maryland.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 75
EP  - 86
VL  - 74
IS  - 2
KW  - Amphetamines
KW  - 0
KW  - Piperazines
KW  - Pyridinium Compounds
KW  - vanoxerine
KW  - 90X28IKH43
KW  - 1-methyl-4-phenyl-2,3-dihydropyridinium
KW  - 94613-45-3
KW  - Apomorphine
KW  - N21FAR7B4S
KW  - 1-Methyl-4-phenylpyridinium
KW  - R865A5OY8J
KW  - Dopamine
KW  - VTD58H1Z2X
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Amphetamines -- pharmacology
KW  - Apomorphine -- pharmacology
KW  - Dopamine -- metabolism
KW  - Piperazines -- pharmacology
KW  - Male
KW  - Substantia Nigra -- metabolism
KW  - Corpus Striatum -- physiology
KW  - Pyridinium Compounds -- toxicity
KW  - Corpus Striatum -- metabolism
KW  - Substantia Nigra -- drug effects
KW  - Corpus Striatum -- drug effects
KW  - Stereotyped Behavior -- drug effects
KW  - Substantia Nigra -- physiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-04-24
N1  - Date created - 1989-04-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Pretreatment with ICRF-187 allows a marked increase in the total cumulative dose of doxorubicin tolerated by beagle dogs.
AN  - 78682334; 3147886
AB  - To study the influence of ICRF-187 on the functional and morphological effects of very large cumulative doses of doxorubicin, adult beagle dogs were given doxorubicin (1.75 mg/kg i.v.) either alone or 15 min after ICRF-187 (25 mg/kg, i.v.) at 3-week intervals. Control dogs received ICRF-187 (25 mg/kg, i.v.) or 0.9% saline without doxorubicin. Of eight animals receiving doxorubicin alone, two died after a total dose of 12.25 mg/kg and three died after 14 mg/kg; three others were in poor condition at the time of euthanasia after 14 mg/kg. Of eight animals receiving both ICRF-187 and doxorubicin, one died after 35 mg/kg, two died after 43.75 mg/kg and one died after 52.5 mg/kg; two dogs were euthanatized after 43.75 mg/kg because of difficulties encountered in giving i.v. injections, and two dogs survived a total dose of 52.5 mg/kg. All control dogs survived. None of the treatment or control groups developed consistent echocardiographic changes or alterations in mean arterial pressure. Dogs given ICRF-187 and doxorubicin developed PQ interval prolongation after 300 days and ventricular premature beats after 500 days. Each animal receiving doxorubicin alone had severe myocardial lesions (lesion score 3+). Of the animals given ICRF-187 and doxorubicin, one that received 35 mg/kg doxorubicin had no lesions; of four given 43.75 mg/kg, three had no lesions and one had minimal lesions (lesion score 1+); of three given 52.5 mg/kg, one had minimal (lesion score 1+) and two had moderate (lesion score 2+) lesions. Control animals had no myocardial lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
JF  - Drugs under experimental and clinical research
AU  - Herman, E H
AU  - Ferrans, V J
AU  - Young, R S
AU  - Hamlin, R L
AD  - Division of Drug Biology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 563
EP  - 570
VL  - 14
IS  - 9
SN  - 0378-6501, 0378-6501
KW  - Piperazines
KW  - 0
KW  - Razoxane
KW  - 5AR83PR647
KW  - Doxorubicin
KW  - 80168379AG
KW  - Index Medicus
KW  - Drug Tolerance
KW  - Animals
KW  - Liver -- pathology
KW  - Drug Interactions
KW  - Myocardium -- pathology
KW  - Electrocardiography
KW  - Echocardiography
KW  - Dogs
KW  - Heart -- drug effects
KW  - Razoxane -- pharmacology
KW  - Razoxane -- administration & dosage
KW  - Heart Diseases -- chemically induced
KW  - Doxorubicin -- toxicity
KW  - Doxorubicin -- administration & dosage
KW  - Piperazines -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-04-18
N1  - Date created - 1989-04-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The projected incidence of AIDS and estimated prevalence of HIV infection in the United States.
AN  - 78670455; 2852243
AB  - Planning for health and social services and for prevention programs requires predicting the number of AIDS cases likely to be diagnosed during the next several years and estimating the prevalence of HIV infection. Extrapolating from recent AIDS incidence data, we estimate that 365,000 AIDS cases will be diagnosed in the United States through 1992 (68% prediction interval, 205,000 to 440,000). Both recent HIV seroprevalence surveys and historical AIDS incidence are consistent with the U.S. Public Health Service estimate that 1.0 to 1.5 million persons in the United States are now infected with human immunodeficiency virus (HIV). Although current estimates of future AIDS cases and of current prevalence of HIV infection are somewhat uncertain, better statistical estimation procedures are being developed, and current surveys will provide additional data on HIV prevalence in the United States within the next several years.
JF  - Journal of acquired immune deficiency syndromes
AU  - Karon, J M
AU  - Dondero, T J
AU  - Curran, J W
AD  - AIDS Program, Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 542
EP  - 550
VL  - 1
IS  - 6
SN  - 0894-9255, 0894-9255
KW  - Index Medicus
KW  - AIDS/HIV
KW  - United States
KW  - Cross-Sectional Studies
KW  - Injections, Intravenous
KW  - Centers for Disease Control and Prevention (U.S.)
KW  - Risk Factors
KW  - Humans
KW  - Health Surveys
KW  - Cohort Studies
KW  - Substance-Related Disorders
KW  - Forecasting
KW  - Homosexuality
KW  - Male
KW  - Female
KW  - Acquired Immunodeficiency Syndrome -- epidemiology
KW  - HIV Seropositivity -- epidemiology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes&rft.atitle=The+projected+incidence+of+AIDS+and+estimated+prevalence+of+HIV+infection+in+the+United+States.&rft.au=Karon%2C+J+M%3BDondero%2C+T+J%3BCurran%2C+J+W&rft.aulast=Karon&rft.aufirst=J&rft.date=1988-01-01&rft.volume=1&rft.issue=6&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes&rft.issn=08949255&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-27
N1  - Date created - 1989-03-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Work-related injuries in minors.
AN  - 78666855; 3228072
AB  - Since 1938, federal child labor laws have restricted employment of persons under 18 years old, in part to protect them from hazardous occupations. Workers' compensation claims reported to the Supplementary Data System of the Bureau of Labor Statistics were examined to define the current status of occupational injuries among minors. Data tapes from 1980 to 1983 were searched to identify all current claims for injuries and illnesses occurring in 1980 in persons under age 18. Injury rates were calculated using information about employment in 1979 available from the 1980 census. In the 24 states included in this study, 23,823 claims were reported for persons less than 18 years old. Of these claims, approximately 10% were from persons under age 16. Rates of injuries in 16- and 17 year olds were 12.6 per 100 full-time male workers and 6.6 per 100 full-time female workers. Serious injuries included fractures, dislocations, and amputations, accounting for 5.8%, 0.7%, and 0.6% of cases, respectively. California, the only state that coded whether injuries resulted in fatalities, reported 12 deaths in this age group. Machines and vehicles, many of which are restricted under child labor laws, accounted for 8.3% and 5.8% of claims. These data suggest that persons under age 18 years are not adequately protected from occupational injury. Further attention and, possibly, new preventive strategies are needed.
JF  - American journal of industrial medicine
AU  - Schober, S E
AU  - Handke, J L
AU  - Halperin, W E
AU  - Moll, M B
AU  - Thun, M J
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45206.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 585
EP  - 595
VL  - 14
IS  - 5
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - United States
KW  - Risk
KW  - Age Factors
KW  - Humans
KW  - Disability Evaluation
KW  - Adolescent
KW  - Male
KW  - Female
KW  - Wounds and Injuries -- epidemiology
KW  - Wounds and Injuries -- etiology
KW  - Accidents, Occupational -- statistics & numerical data
KW  - Occupational Diseases -- etiology
KW  - Occupational Diseases -- epidemiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78666855?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Work-related+injuries+in+minors.&rft.au=Schober%2C+S+E%3BHandke%2C+J+L%3BHalperin%2C+W+E%3BMoll%2C+M+B%3BThun%2C+M+J&rft.aulast=Schober&rft.aufirst=S&rft.date=1988-01-01&rft.volume=14&rft.issue=5&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-29
N1  - Date created - 1989-03-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Comparative antimutagenicity of chlorophyllin and five other agents against aflatoxin B1-induced reversion in Salmonella typhimurium strain TA98.
AN  - 78661451; 2906179
AB  - Chlorophyllin was studied for its antimutagenic activity against aflatoxin B1 in Salmonella typhimurium strain TA98 using the plate-incorporation test in the presence of S9 activation. Comparative antimutagenicity between chlorophyllin and certain commonly studied antimutagens (i.e., vitamins A, C, and E, retinoic acid, and beta-carotene) was also examined. A dose-related inhibition of aflatoxin B1 mutagenicity by chlorophyllin was observed, with the mutagenicity being abolished by 860 nmole chlorophyllin per plate. The inhibitory activity of chlorophyllin occurred only when cells were treated concurrently with chlorophyllin and aflatoxin B1. The antimutagenic potency of chlorophyllin was comparable to that of vitamin A and higher than that of retinoic acid and beta-carotene. Vitamins C and E had no effect on aflatoxin B1 mutagenicity under the conditions used. The results of toxicity tests and a reconstruction experiment showed that inhibition of the mutagenicity of aflatoxin B1 by chlorophyllin and the other active agents was due to antimutagenicity.
JF  - Teratogenesis, carcinogenesis, and mutagenesis
AU  - Whong, W Z
AU  - Stewart, J
AU  - Brockman, H E
AU  - Ong, T M
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 215
EP  - 224
VL  - 8
IS  - 4
SN  - 0270-3211, 0270-3211
KW  - Aflatoxins
KW  - 0
KW  - Chlorophyllides
KW  - Vitamins
KW  - beta Carotene
KW  - 01YAE03M7J
KW  - Vitamin A
KW  - 11103-57-4
KW  - Vitamin E
KW  - 1406-18-4
KW  - Chlorophyll
KW  - 1406-65-1
KW  - chlorophyllin
KW  - 1D276TYV9O
KW  - Carotenoids
KW  - 36-88-4
KW  - Tretinoin
KW  - 5688UTC01R
KW  - Aflatoxin B1
KW  - 9N2N2Y55MH
KW  - Ascorbic Acid
KW  - PQ6CK8PD0R
KW  - Index Medicus
KW  - Tretinoin -- pharmacology
KW  - Mutagenicity Tests -- methods
KW  - Vitamin A -- pharmacology
KW  - Vitamin E -- pharmacology
KW  - Carotenoids -- pharmacology
KW  - Ascorbic Acid -- pharmacology
KW  - Vitamins -- pharmacology
KW  - Chlorophyllides -- pharmacology
KW  - Aflatoxins -- pharmacology
KW  - Salmonella typhimurium -- drug effects
KW  - Mutation
KW  - Chlorophyll -- analogs & derivatives
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Comparative+antimutagenicity+of+chlorophyllin+and+five+other+agents+against+aflatoxin+B1-induced+reversion+in+Salmonella+typhimurium+strain+TA98.&rft.au=Whong%2C+W+Z%3BStewart%2C+J%3BBrockman%2C+H+E%3BOng%2C+T+M&rft.aulast=Whong&rft.aufirst=W&rft.date=1988-01-01&rft.volume=8&rft.issue=4&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-03-23
N1  - Date created - 1989-03-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neuropathological evaluation by combined immunohistochemistry and degeneration-specific methods: application to methylenedioxymethamphetamine.
AN  - 78578578; 2904668
AB  - To best interpret the significance of neurological alterations produced by chemicals, the changes in morphological as well as neurochemical parameters must be measured and compared to each other. We have devised an approach to readily label microscopic sections for multiple antigens (neurotransmitters, enzymes, peptides, etc.) as well as for the demonstration of degenerating structures by silver impregnation. Here, we applied silver-staining together with immunolabelling of 5-HT and tyrosine hydroxylase (the rate-limiting enzyme for dopamine synthesis) to study neurohistological alterations produced by methylenedioxymethamphetamine (MDMA), a hallucinogenic stimulant previously used as an adjunct to psychotherapy and now a popular recreational drug ("Ecstasy"). Single oral doses of 40 or 80 mg/kg MDMA doubled the density of silver-impregnated (degenerating) fiber terminals in the caudate nucleus compared to controls, when rats were sacrificed 18 hours after treatment. Four months after two 40 mg/kg oral doses per day for four days, rats had a reduced neurochemical content of 5-HT in the hippocampus, and fewer immunostainable 5-HT axons per unit area in the hippocampal stratum lacunosum but no change in brain-stem neurochemical 5-HT content or in the numeric density of 5-HT-positive cell bodies in the dorsal raphe nucleus. The neurohistology suggests interpreting the changes in neurochemical content of serotonin produced by MDMA as due to degeneration followed by subsequent loss of 5-HT axons, rather than a decrease in the rate of neuronal 5-HT synthesis or a toxicity directed toward 5-HT cell bodies. The combination of neurohistological and neurochemical evaluation will continue to prove useful in comprehensive evaluation of the neurological effects of chemical exposure.
JF  - Neurotoxicology
AU  - Scallet, A C
AU  - Lipe, G W
AU  - Ali, S F
AU  - Holson, R R
AU  - Frith, C H
AU  - Slikker, W
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 529
EP  - 537
VL  - 9
IS  - 3
SN  - 0161-813X, 0161-813X
KW  - Amphetamines
KW  - 0
KW  - Serotonin
KW  - 333DO1RDJY
KW  - 3,4-Methylenedioxyamphetamine
KW  - 4764-17-4
KW  - Tyrosine 3-Monooxygenase
KW  - EC 1.14.16.2
KW  - N-Methyl-3,4-methylenedioxyamphetamine
KW  - KE1SEN21RM
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Nerve Degeneration
KW  - Animals
KW  - Axons -- drug effects
KW  - Caudate Nucleus -- pathology
KW  - Caudate Nucleus -- drug effects
KW  - Immunohistochemistry
KW  - Male
KW  - 3,4-Methylenedioxyamphetamine -- analysis
KW  - 3,4-Methylenedioxyamphetamine -- analogs & derivatives
KW  - 3,4-Methylenedioxyamphetamine -- toxicity
KW  - Amphetamines -- toxicity
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Neuropathological+evaluation+by+combined+immunohistochemistry+and+degeneration-specific+methods%3A+application+to+methylenedioxymethamphetamine.&rft.au=Scallet%2C+A+C%3BLipe%2C+G+W%3BAli%2C+S+F%3BHolson%2C+R+R%3BFrith%2C+C+H%3BSlikker%2C+W&rft.aulast=Scallet&rft.aufirst=A&rft.date=1988-01-01&rft.volume=9&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-19
N1  - Date created - 1989-01-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Quantitation of complex brain function in children: preliminary evaluation using a nonhuman primate behavioral test battery.
AN  - 78578547; 3143955
AB  - The performance of twenty children (3-11 years of age) in a complex operant test battery (OTB) was evaluated. The operant schedules, or tasks, used in the OTB were identical to those originally designed and currently used to assess complex brain function in nonhuman primate laboratory animals (monkeys). The OTB consisted of five operant tasks: 1) Progressive-Ratio [PR]; 2) Conditioned-Position Responding [CPR]; 3) Temporal Response Differentiation [TRD]; 4) Delayed Matching-to-Sample [DMTS] and 5) Incremental Repeated Acquisition [IRA]. These operant tasks are thought to engender responding indicative of processes associated with: 1) motivation; 2) color and position discrimination; 3) time-perception; 4) short-term memory and attention; and 5) learning, respectively. The parameters for each of the tasks in the OTB were optimized for use in the clinical setting to assess cognitive function in children. In the small population studied, performance in the IRA, DMB and TRD tasks was age related. Of the four 6-yr-olds studied, only those categorized as having either learning disabilities (LD, n = 1) or attention deficit disorders (ADD, n = 2) did not complete the "learning" task. By comparison of human and monkey performance in the OTB, we also hope to validate the use of laboratory animal models in research efforts designed to yield insight into complex human brain function. It is also hoped that assessment of children's performance in the tasks in the OTB will assist in the diagnosis and treatment of certain childhood disorders such as learning disabilities and/or attention deficit disorders.
JF  - Neurotoxicology
AU  - Paule, M G
AU  - Cranmer, J M
AU  - Wilkins, J D
AU  - Stern, H P
AU  - Hoffman, E L
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 367
EP  - 378
VL  - 9
IS  - 3
SN  - 0161-813X, 0161-813X
KW  - Index Medicus
KW  - Animals
KW  - Humans
KW  - Disease Models, Animal
KW  - Child
KW  - Attention
KW  - Male
KW  - Learning Disorders -- diagnosis
KW  - Female
KW  - Child, Preschool
KW  - Psychological Tests -- instrumentation
KW  - Conditioning, Operant
KW  - Psychological Tests -- methods
KW  - Brain -- physiology
KW  - Haplorhini
KW  - Cognition
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78578547?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Quantitation+of+complex+brain+function+in+children%3A+preliminary+evaluation+using+a+nonhuman+primate+behavioral+test+battery.&rft.au=Paule%2C+M+G%3BCranmer%2C+J+M%3BWilkins%2C+J+D%3BStern%2C+H+P%3BHoffman%2C+E+L&rft.aulast=Paule&rft.aufirst=M&rft.date=1988-01-01&rft.volume=9&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-19
N1  - Date created - 1989-01-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Complex brain function in monkeys as a baseline for studying the effects of exogenous compounds.
AN  - 78578511; 3143956
AB  - We have examined the population characteristics of a group of 69 monkey subjects performing in a complex operant test battery designed to generate behaviors indicative of specific brain functions. These functions include learning, short-term memory and attention, time perception, position and color discrimination and motivation. Performance by a subject in one of these operant tasks is not necessarily correlated with or predictive of performance in the other tasks, indicating that the tests in the battery are monitoring the functions of different brain systems. Additionally, as demonstrated by challenging a few of the animals with intravenous delta-9-tetrahydrocannabinol, we have shown that the performances in the various components of the test battery are differentially sensitive to disruption by exogenous compounds.
JF  - Neurotoxicology
AU  - Paule, M G
AU  - Schulze, G E
AU  - Slikker, W
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 463
EP  - 470
VL  - 9
IS  - 3
SN  - 0161-813X, 0161-813X
KW  - Hazardous Substances
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Brain -- physiology
KW  - Hazardous Substances -- toxicity
KW  - Haplorhini -- physiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78578511?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Complex+brain+function+in+monkeys+as+a+baseline+for+studying+the+effects+of+exogenous+compounds.&rft.au=Paule%2C+M+G%3BSchulze%2C+G+E%3BSlikker%2C+W&rft.aulast=Paule&rft.aufirst=M&rft.date=1988-01-01&rft.volume=9&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-19
N1  - Date created - 1989-01-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neurochemical evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine.
AN  - 78576007; 2904669
AB  - Clonidine (CLON), an alpha-2 adrenergic agonist, is widely used to reduce hypertension; it is also recommended for blocking acute opiate withdrawal. Lofexidine (LOF), a CLON analog, is an investigational compound being readied for the marketplace. Since exposure to both drugs is likely to occur in the last two trimesters of human pregnancy, it is important to determine whether such exposure can have effects upon brain or behavior of offspring. Pregnant CD rat dams were given daily subcutaneous injections of saline, CLON, or LOF on days 8 through 20 of gestation. Maternal weight during gestation, neonatal weight and neurochemical measures were monitored. Maternal body weight was reduced in a dose dependent manner. At PND 1 brain ornithine decarboxylase (ODC) activity was reduced in LOF- but not CLON-exposed pups of both sexes. At this age no alteration was seen in whole brain catecholamine levels or in whole brain alpha-2-adrenergic binding.
JF  - Neurotoxicology
AU  - Ali, S F
AU  - Holson, R R
AU  - Pizzi, W J
AU  - Newport, G D
AU  - Slikker, W
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 551
EP  - 557
VL  - 9
IS  - 3
SN  - 0161-813X, 0161-813X
KW  - Adrenergic alpha-Agonists
KW  - 0
KW  - Antihypertensive Agents
KW  - Membrane Proteins
KW  - Neurotransmitter Agents
KW  - apraclonidine
KW  - 843CEN85DI
KW  - Ornithine Decarboxylase
KW  - EC 4.1.1.17
KW  - Clonidine
KW  - MN3L5RMN02
KW  - lofexidine
KW  - UI82K0T627
KW  - Index Medicus
KW  - Rats
KW  - Ornithine Decarboxylase -- metabolism
KW  - Animals
KW  - Neurotransmitter Agents -- analysis
KW  - Brain -- drug effects
KW  - Body Weight -- drug effects
KW  - Membrane Proteins -- analysis
KW  - Drug Evaluation, Preclinical
KW  - Adrenergic alpha-Agonists -- metabolism
KW  - Female
KW  - Pregnancy
KW  - Antihypertensive Agents -- toxicity
KW  - Clonidine -- metabolism
KW  - Clonidine -- analogs & derivatives
KW  - Brain Chemistry
KW  - Clonidine -- toxicity
KW  - Prenatal Exposure Delayed Effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Neurochemical+evaluation+of+rats+prenatally+exposed+to+the+adrenergic+agonists+clonidine+and+lofexidine.&rft.au=Ali%2C+S+F%3BHolson%2C+R+R%3BPizzi%2C+W+J%3BNewport%2C+G+D%3BSlikker%2C+W&rft.aulast=Ali&rft.aufirst=S&rft.date=1988-01-01&rft.volume=9&rft.issue=3&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-19
N1  - Date created - 1989-01-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - DNA adduct formation during continuous feeding of 2-acetylaminofluorene at multiple concentrations.
AN  - 78568126; 3198200
AB  - A linear relationship was observed between the administered dose and DNA adduct levels in the livers and bladders of BALB/c mice fed the carcinogen, 2-acetylaminofluorene (2-AAF), continuously for one month. A similar linear correlation was found between the probit of the liver tumour incidence and the log of the liver DNA adduct levels; however, because there is a no-observable-effect level for bladder tumour induction, the relationship between the probit of the bladder tumour incidence and bladder DNA adduct levels was not linear. These data suggest that the relationship between DNA adduct formation and tumour incidence may be tissue specific.
JF  - IARC scientific publications
AU  - Beland, F A
AU  - Fullerton, N F
AU  - Kinouchi, T
AU  - Poirier, M C
AD  - National Center for Toxicological Research, Jefferson, AR.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 175
EP  - 180
IS  - 89
SN  - 0300-5038, 0300-5038
KW  - DNA
KW  - 9007-49-2
KW  - 2-Acetylaminofluorene
KW  - 9M98QLJ2DL
KW  - Index Medicus
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Liver Neoplasms, Experimental -- chemically induced
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Female
KW  - Urinary Bladder Neoplasms -- chemically induced
KW  - 2-Acetylaminofluorene -- metabolism
KW  - DNA -- metabolism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=DNA+adduct+formation+during+continuous+feeding+of+2-acetylaminofluorene+at+multiple+concentrations.&rft.au=Beland%2C+F+A%3BFullerton%2C+N+F%3BKinouchi%2C+T%3BPoirier%2C+M+C&rft.aulast=Beland&rft.aufirst=F&rft.date=1988-01-01&rft.volume=&rft.issue=89&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-18
N1  - Date created - 1989-01-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Biomarkers in aging and toxicity.
AN  - 78566165; 3197778
JF  - Experimental gerontology
AU  - Hart, R W
AU  - Turturro, A
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 241
EP  - 243
VL  - 23
IS  - 4-5
SN  - 0531-5565, 0531-5565
KW  - Biomarkers
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Aging -- metabolism
KW  - Biomarkers -- analysis
KW  - Toxicology -- methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78566165?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+gerontology&rft.atitle=Biomarkers+in+aging+and+toxicity.&rft.au=Hart%2C+R+W%3BTurturro%2C+A&rft.aulast=Hart&rft.aufirst=R&rft.date=1988-01-01&rft.volume=23&rft.issue=4-5&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Experimental+gerontology&rft.issn=05315565&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-26
N1  - Date created - 1989-01-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Assessment of exposure and susceptibility to aromatic amine carcinogens.
AN  - 78565630; 3198199
AB  - As a consequence of human exposure to carcinogenic aromatic amines, biochemical approaches to risk assessment have emphasized metabolic determinants of individual susceptibility and quantification of arylamine-macromolecular adducts. A known genetic polymorphism in humans, hepatic arylamine acetyltransferase activity, has been associated with differences in individual susceptibility to urinary bladder (slow acetylators) and colorectal (rapid acetylators) cancers. Similarly, the high specificity of an inducible human cytochrome P450 towards the N-oxidation of 4-aminobiphenyl and other aromatic amines is consistent with metabolic differences that can be used to predict relative human risk. Exposure to aromatic amines has also been documented, primarily by quantification of adducts with protein or DNA. Using 32P-postlabelling methods and a competitive avidin/biotin-amplified enzyme-linked immunoassay, we have estimated 4-aminobiphenyl-DNA adduct levels in surgical samples of human peripheral lung and urinary bladder epithelium and report values ranging from 2 to 97 adducts per 10(8) nucleotides.
JF  - IARC scientific publications
AU  - Kadlubar, F F
AU  - Talaska, G
AU  - Lang, N P
AU  - Benson, R W
AU  - Roberts, D W
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 166
EP  - 174
IS  - 89
SN  - 0300-5038, 0300-5038
KW  - Amines
KW  - 0
KW  - Aminobiphenyl Compounds
KW  - Carcinogens, Environmental
KW  - 4-biphenylamine
KW  - 16054949HJ
KW  - DNA
KW  - 9007-49-2
KW  - Cytochrome P-450 Enzyme System
KW  - 9035-51-2
KW  - Index Medicus
KW  - Acetylation
KW  - Polymorphism, Genetic
KW  - Humans
KW  - DNA -- metabolism
KW  - Cytochrome P-450 Enzyme System -- physiology
KW  - Colorectal Neoplasms -- etiology
KW  - Aminobiphenyl Compounds -- metabolism
KW  - Urinary Bladder Neoplasms -- chemically induced
KW  - Amines -- toxicity
KW  - Carcinogens, Environmental -- metabolism
KW  - Carcinogens, Environmental -- toxicity
KW  - Environmental Monitoring -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-18
N1  - Date created - 1989-01-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Bladder tumors in two young males occupationally exposed to MBOCA.
AN  - 78538734; 3189344
AB  - MBOCA (4,4' methylenebis (2-chloroaniline) is a structural analogue of benzidine and is carcinogenic in mice, rats, and dogs. MBOCA has not yet been demonstrated to be carcinogenic in humans and is not regulated as an occupational carcinogen in the United States. We report two noninvasive papillary tumors of the bladder identified in a screening study of 540 workers exposed to MBOCA during its production at a Michigan chemical plant from 1968 to 1979. Both tumors occurred in men under 30 years old who had never smoked. Although the prevalence of grade 1-2 tumors among asymptomatic males in this age group is unknown, the incidence of clinically apparent tumors on U.S. males aged 25-29 is only 1 per 100,000 per year. The detection of the two tumors in young, nonsmoking males is consistent with the hypothesis that MBOCA induces bladder neoplasms in humans.
JF  - American journal of industrial medicine
AU  - Ward, E
AU  - Halperin, W
AU  - Thun, M
AU  - Grossman, H B
AU  - Fink, B
AU  - Koss, L
AU  - Osorio, A M
AU  - Schulte, P
AD  - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 267
EP  - 272
VL  - 14
IS  - 3
SN  - 0271-3586, 0271-3586
KW  - Benzhydryl Compounds
KW  - 0
KW  - Methylenebis(chloroaniline)
KW  - 3L2W5VTT2A
KW  - Index Medicus
KW  - Humans
KW  - Adult
KW  - Cystoscopy
KW  - Male
KW  - Carcinoma, Transitional Cell -- pathology
KW  - Urinary Bladder Neoplasms -- pathology
KW  - Carcinoma, Papillary -- pathology
KW  - Benzhydryl Compounds -- adverse effects
KW  - Carcinoma, Transitional Cell -- chemically induced
KW  - Carcinoma, Papillary -- chemically induced
KW  - Occupational Diseases -- chemically induced
KW  - Urinary Bladder Neoplasms -- chemically induced
KW  - Methylenebis(chloroaniline) -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Bladder+tumors+in+two+young+males+occupationally+exposed+to+MBOCA.&rft.au=Ward%2C+E%3BHalperin%2C+W%3BThun%2C+M%3BGrossman%2C+H+B%3BFink%2C+B%3BKoss%2C+L%3BOsorio%2C+A+M%3BSchulte%2C+P&rft.aulast=Ward&rft.aufirst=E&rft.date=1988-01-01&rft.volume=14&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-02
N1  - Date created - 1988-12-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Forestomach lesions induced by butylated hydroxyanisole and ethylene dibromide: a scientific and regulatory perspective.
AN  - 78528293; 3055227
AB  - Selected pathology lesions from 9 studies, 5 with butylated hydroxyanisole (BHA) and 4 with ethylene dibromide (EDB) are reviewed and their relative importance in regulatory evaluation is discussed. When Fischer 344 (F344) rats were fed BHA at 0.5% and 2.0% of the diet for 2 years, an increased number of rats of both sexes had epithelial hyperplasia of the forestomach at both treatment levels, compared to controls. At the 2.0% level, an increased number of rats had forestomach papilloma or forestomach squamous cell carcinoma. In a second study, in which F344 rats were fed BHA at 1.0% and 2.0% of the diet for 2 years, increased numbers of rats in both treatment groups were reported to have hyperplasia or papilloma of the forestomach. At the 2.0% level, increased numbers of rats developed squamous cell carcinoma of the forestomach. More Syrian golden hamsters fed BHA at 1.0% and 2.0% of the diet for 2 years reportedly had hyperplasia, papilloma or squamous cell carcinoma of the forestomach than did nontreated animals. Ingestion of BHA at 0.5% and 1.0% of the diet by B6C3F1 mice for 2 years was reported to produce an increase of animals with hyperplasia or papilloma of the forestomach at both dosage levels, compared to nontreated mice. When beagle dogs were fed BHA at 1.0% and 1.3% of the diet for 180 days, no lesions/tumors of the distal esophagus or stomach were identified at gross necropsy or by light or electron microscopy. When EDB was administered by gavage to Osborne-Mendel rats and B6C3F1 mice under conditions of the National Toxicology Bioassay Program, more rats and mice, both male and female, developed squamous cell carcinoma of the forestomach than did nontreated groups. EDB administered via inhalation to F344 rats and B6C3F1 mice did not cause squamous cell carcinoma of the forestomach; however, other neoplasms occurred which were considered to be treatment-related. Information gleaned from the BHA and EDB studies with multiple animal species facilitated regulatory decision-making regarding the potential toxicity/carcinogenicity of these compounds to man.
JF  - Toxicologic pathology
AU  - Moch, R W
AD  - Office of Toxicological Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 172
EP  - 183
VL  - 16
IS  - 2
SN  - 0192-6233, 0192-6233
KW  - Carcinogens
KW  - 0
KW  - Hydrocarbons, Brominated
KW  - Ethylene Dibromide
KW  - 1N41638RNO
KW  - Butylated Hydroxyanisole
KW  - 25013-16-5
KW  - Index Medicus
KW  - Rats
KW  - Administration, Oral
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Rats, Inbred F344
KW  - Dogs
KW  - Mesocricetus
KW  - Mice
KW  - Administration, Inhalation
KW  - Male
KW  - Female
KW  - Cricetinae
KW  - Butylated Hydroxyanisole -- administration & dosage
KW  - Stomach Diseases -- chemically induced
KW  - Carcinogens -- administration & dosage
KW  - Stomach Neoplasms -- chemically induced
KW  - Ethylene Dibromide -- administration & dosage
KW  - Butylated Hydroxyanisole -- toxicity
KW  - Ethylene Dibromide -- toxicity
KW  - Hydrocarbons, Brominated -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-15
N1  - Date created - 1988-12-15
N1  - Date revised - 2017-02-15
N1  - Last updated - 2017-02-15
ER  - 



TY  - JOUR
T1  - Long-term visual health risks from solar ultraviolet radiation. Proposals for ocular protection.
AN  - 78514511; 3186191
AB  - Several clinical observations suggest the necessity of protective measures to prevent eye damage from solar ultraviolet radiation. Recommendations for protection are given.
JF  - Ophthalmic research
AU  - Waxler, M
AD  - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 179
EP  - 182
VL  - 20
IS  - 3
SN  - 0030-3747, 0030-3747
KW  - Index Medicus
KW  - Photochemistry
KW  - Risk Factors
KW  - Humans
KW  - Retinal Diseases -- etiology
KW  - Dose-Response Relationship, Radiation
KW  - Time Factors
KW  - Eyeglasses
KW  - Vision Disorders -- etiology
KW  - Sunlight -- adverse effects
KW  - Ultraviolet Rays -- adverse effects
KW  - Vision Disorders -- prevention & control
KW  - Radiation Injuries
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-28
N1  - Date created - 1988-11-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Benzene: uses, occurrence and exposure.
AN  - 78502010; 3053449
JF  - IARC scientific publications
AU  - Fishbein, L
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 67
EP  - 96
IS  - 85
SN  - 0300-5038, 0300-5038
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Benzene
KW  - J64922108F
KW  - Index Medicus
KW  - Chemistry
KW  - Risk Factors
KW  - Chemical Phenomena
KW  - Environmental Exposure
KW  - Environmental Monitoring
KW  - Chemical Industry
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Benzene%3A+uses%2C+occurrence+and+exposure.&rft.au=Fishbein%2C+L&rft.aulast=Fishbein&rft.aufirst=L&rft.date=1988-01-01&rft.volume=&rft.issue=85&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-21
N1  - Date created - 1988-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Past and present exposure determination techniques for benzene, toluene and xylene.
AN  - 78495253; 3053441
JF  - IARC scientific publications
AU  - Fishbein, L
AU  - O'Neill, I K
AU  - Tossavainen, A
AD  - Department of Health and Human Sciences, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 123
EP  - 148
IS  - 85
SN  - 0300-5038, 0300-5038
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Xylenes
KW  - Toluene
KW  - 3FPU23BG52
KW  - Benzene
KW  - J64922108F
KW  - Index Medicus
KW  - Benzene -- analysis
KW  - Air Pollutants, Occupational -- analysis
KW  - Toluene -- analysis
KW  - Xylenes -- analysis
KW  - Environmental Monitoring -- methods
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Past+and+present+exposure+determination+techniques+for+benzene%2C+toluene+and+xylene.&rft.au=Fishbein%2C+L%3BO%27Neill%2C+I+K%3BTossavainen%2C+A&rft.aulast=Fishbein&rft.aufirst=L&rft.date=1988-01-01&rft.volume=&rft.issue=85&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-21
N1  - Date created - 1988-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Genetic effects of benzene, toluene and xylene.
AN  - 78492259; 3053445
JF  - IARC scientific publications
AU  - Fishbein, L
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 19
EP  - 46
IS  - 85
SN  - 0300-5038, 0300-5038
KW  - Xylenes
KW  - 0
KW  - Toluene
KW  - 3FPU23BG52
KW  - Benzene
KW  - J64922108F
KW  - Index Medicus
KW  - Animals
KW  - Mutagenicity Tests
KW  - Humans
KW  - Xylenes -- toxicity
KW  - Benzene -- metabolism
KW  - Chromosome Aberrations
KW  - Benzene -- toxicity
KW  - Toluene -- metabolism
KW  - Xylenes -- metabolism
KW  - Toluene -- toxicity
KW  - Mutation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-12-21
N1  - Date created - 1988-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Toxicity of inhaled isobutyl nitrite in BALB/c mice: systemic and immunotoxic studies.
AN  - 78453298; 3140021
JF  - NIDA research monograph
AU  - Lewis, D M
AU  - Lynch, D W
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 50
EP  - 58
VL  - 83
SN  - 1046-9516, 1046-9516
KW  - Antigens, Surface
KW  - 0
KW  - Nitrites
KW  - isobutyl nitrite
KW  - GW9WAB6QOM
KW  - Index Medicus
KW  - Animals
KW  - Methemoglobinemia -- immunology
KW  - Body Weight -- drug effects
KW  - Immunity, Cellular -- drug effects
KW  - Methemoglobinemia -- chemically induced
KW  - Mice
KW  - Antigens, Surface -- metabolism
KW  - Mice, Inbred BALB C
KW  - Administration, Inhalation
KW  - Male
KW  - Female
KW  - Antibody Formation -- drug effects
KW  - Organ Size -- drug effects
KW  - Nitrites -- administration & dosage
KW  - Nitrites -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-11-09
N1  - Date created - 1988-11-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Fibrogenicity and carcinogenic potential of smelter slags used as abrasive blasting substitutes.
AN  - 78432236; 2458479
AB  - This study was designed to examine the fibrogenic and carcinogenic potentials of three smelter slags (primary copper slag, secondary copper slag, and nickel slag) that have been used for a number of years as substitutes for sand in abrasive blasting operations. Seven groups of 85 male Fischer 344 rats (approximately 180 g) were used. Each group was given a single 20-mg dose of one of the following test materials via intratracheal instillation: primary copper slag, secondary copper slag, nickel slag, feldspar, Min-U-Sil, novaculite, or vehicle control. Chemical, particle size, and surface area analyses were performed for each test dust. Animals were weighed monthly, and ten animals per group were necropsied at the 6-, 12-, and 18-mo interim sacrifices. The terminal sacrifice was conducted at 22 mo. Hematoxylin and eosin stained histologic sections were prepared from designated formalin-fixed tissues collected at necropsy and examined microscopically. The pulmonary fibrogenic and carcinogenic potentials of the three smelter slags were compared histopathologically with feldspar, novaculite, Min-U-Sil, and vehicle controls. Only minimal to slight alveolar wall fibrosis was seen in the two copper slag groups, while the response seen with nickel slag was consistent with a foreign body reaction with minimal fibrosis seen in only an occasional animal. The major reaction seen in both the feldspar- and the novaculite-treated rats was a granulomatous inflammation with varying degrees of fibrosis associated with the granulomas. Significant numbers of primary lung tumors, principally adenocarcinomas and adenomas, were seen in the copper slag (p = 0.005 and p = 0.022 for the primary and secondary slags, respectively), in the feldspar (p = 0.007), in the novaculite (p less than 0.001), and in the Min-U-Sil (p less than 0.001) groups when compared to the vehicle control group. In addition, the Min-U-Sil and novaculite groups had significantly elevated pulmonary tumor proportions relative to the other treatments (p less than or equal to 0.002), with the Min-U-Sil being higher than the novaculite (p = 0.012). On the basis of the tumor incidence data, one must conclude that both copper slags tested in this study are carcinogenic to rats.
JF  - Journal of toxicology and environmental health
AU  - Stettler, L E
AU  - Proctor, J E
AU  - Platek, S F
AU  - Carolan, R J
AU  - Smith, R J
AU  - Donaldson, H M
AD  - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 35
EP  - 56
VL  - 25
IS  - 1
SN  - 0098-4108, 0098-4108
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Dust
KW  - Copper
KW  - 789U1901C5
KW  - Nickel
KW  - 7OV03QG267
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Rats, Inbred F344
KW  - Granuloma -- chemically induced
KW  - Granuloma -- pathology
KW  - Particle Size
KW  - Environmental Exposure
KW  - Staining and Labeling
KW  - Surface Properties
KW  - Pulmonary Fibrosis -- pathology
KW  - Pulmonary Fibrosis -- chemically induced
KW  - Nickel -- toxicity
KW  - Lung Neoplasms -- chemically induced
KW  - Air Pollutants, Occupational -- toxicity
KW  - Copper -- toxicity
KW  - Lung Neoplasms -- pathology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Fibrogenicity+and+carcinogenic+potential+of+smelter+slags+used+as+abrasive+blasting+substitutes.&rft.au=Stettler%2C+L+E%3BProctor%2C+J+E%3BPlatek%2C+S+F%3BCarolan%2C+R+J%3BSmith%2C+R+J%3BDonaldson%2C+H+M&rft.aulast=Stettler&rft.aufirst=L&rft.date=1988-01-01&rft.volume=25&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-27
N1  - Date created - 1988-10-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Heat shock and herpes virus: enhanced reactivation without untargeted mutagenesis.
AN  - 78378609; 2842152
AB  - Enhanced reactivation of Ultraviolet-irradiated virus has been reported to occur in heat-shocked host cells. Since enhanced virus reactivation is often accompanied by untargeted mutagenesis, we investigated whether such mutagenesis would occur for herpes simplex virus (HSV) in CV-1 monkey kidney cells subjected to heat shock. In addition to expressing enhanced reactivation, the treated cells were transiently more susceptible to infection by unirradiated HSV. No mutagenesis of unirradiated HSV was found whether infection occurred at the time of increased susceptibility to infection or during expression of enhanced viral reactivation.
JF  - Environmental and molecular mutagenesis
AU  - Lytle, C D
AU  - Carney, P G
AD  - Division of Life Sciences, Center for Devices and Radiological Health, Rockville, MD 20857.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 201
EP  - 207
VL  - 12
IS  - 2
SN  - 0893-6692, 0893-6692
KW  - Index Medicus
KW  - Ultraviolet Rays
KW  - Mutation
KW  - Hot Temperature
KW  - Virus Activation
KW  - Simplexvirus -- growth & development
KW  - Simplexvirus -- radiation effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-28
N1  - Date created - 1988-09-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Cancer mortality among northern Georgia carpet and textile workers.
AN  - 78364246; 3407646
AB  - Proportionate cancer mortality was analyzed among white male carpet and textile workers in five northwest Georgia counties for the years 1970-1984. Compared with other Georgians, carpet and textile workers had higher proportions of lymphocytic leukemia (proportionate cancer mortality ratio [PCMR] = 2.9; 95% CI = 1.4-5.4]) and testicular cancer (PCMR = 3.2; 95% CI = 1.0-7.5). The excess mortality from lymphocytic leukemia was even higher when the analysis was limited to workers deemed most likely to work directly in production areas (PCMR = 4.2; 95% CI = 1.7-8.7). Further studies are needed to determine if the observed excesses are the result of workplace exposures.
JF  - American journal of industrial medicine
AU  - O'Brien, T R
AU  - Decouflé, P
AD  - Centers for Disease Control, Public Health Service, Atlanta, GA 30333.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 15
EP  - 24
VL  - 14
IS  - 1
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - Leukemia, Lymphoid -- mortality
KW  - Humans
KW  - Genital Neoplasms, Male -- mortality
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Georgia
KW  - Male
KW  - Floors and Floorcoverings
KW  - Neoplasms -- mortality
KW  - Facility Design and Construction
KW  - Textile Industry
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-15
N1  - Date created - 1988-09-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Intravenous drug abuse and AIDS transmission: Federal and State laws regulating needle availability.
AN  - 78353219; 3136338
AB  - This paper has surveyed the laws restricting the use of hypodermic needles and syringes for injection of illegal drugs. It has reviewed the constitutional basis for these laws and concluded that they are on sound footing. There is a new Federal law regulating needles and syringes in interstate commerce, but it is too early to tell how expansively it will be implemented. A large majority of States have drug paraphernalia laws that govern needles and syringes, and a smaller number have laws that require prescriptions for the sale and possession of needles and syringes. Some local jurisdictions also have laws, but these were not specifically reviewed. Altogether, a breadth of relevant laws govern the manufacture, sale, use or possession, advertisement, and interstate commerce of needles and syringes intended for use with illegal drugs. Any attempt by scientists or public health officials to accurately study the effect of these legal restrictions on the HIV infection rates in differing jurisdictions must comprehensively consider the applicable laws. Likewise, attempts at legislative change must also identify each law that would apply. Prosecutorial discretion has been discussed as it relates to the decision not to prosecute offenses involving the illegal use of needles and syringes. While prosecutorial discretion is most likely to be used by prosecutors in individual cases, it provides a legally sound approach for a prosecutor who decides not to enforce the needle and syringe laws across the board as part of an HIV infection control program. Although this approach has not yet been adopted in this country, a prosecutor's decision not to enforce these laws might allow the establishment of an experimental program, such as one for needle exchange, that could serve as a laboratory for legislative initiatives.
JF  - NIDA research monograph
AU  - Pascal, C B
AD  - Alcohol, Drug Abuse, and Mental Health Administration, Department of Health and Human Services, Rockville, MD 20857.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 119
EP  - 136
VL  - 80
SN  - 1046-9516, 1046-9516
KW  - Index Medicus
KW  - AIDS/HIV
KW  - United States
KW  - Crime
KW  - Injections, Intravenous
KW  - Humans
KW  - Needles
KW  - Acquired Immunodeficiency Syndrome -- transmission
KW  - Substance-Related Disorders -- complications
KW  - Legislation, Drug
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-09-15
N1  - Date created - 1988-09-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Effect of nitrous oxide on embryonic macromolecular synthesis and purine levels.
AN  - 78327161; 2456630
AB  - Nitrous oxide (N2O), an anesthetic gas, has been implicated as a human teratogen. The mechanism for its developmental toxicant effects is not known but may involve depression of embryonic macromolecular synthesis caused by alterations in precursor concentrations. Such changes might be caused by decreased folate levels. Pregnant rats were exposed to 50% N2O for 24 hours on day 10 of gestation; this is not an anesthetic dose. Embryos were removed immediately after exposure and grown in a rodent whole embryo culture system for 4 hours in medium containing radiolabeled precursors for RNA or protein. Exposure to N2O decreased embryonic DNA and RNA contents but did not alter number of somite pairs or protein content. Such treatment also decreased incorporation of radiolabeled uridine into acid-precipitable RNA. There was no difference between control and treated embryos in the incorporation of radiolabeled leucine into protein. There were also no differences between control and exposed embryos in the level of acid-soluble purines. The lower DNA and RNA contents in N2O-treated embryos are apparently not the result of decreased levels of adenine or guanine.
JF  - Teratogenesis, carcinogenesis, and mutagenesis
AU  - Hansen, D K
AU  - Grafton, T F
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 107
EP  - 115
VL  - 8
IS  - 2
SN  - 0270-3211, 0270-3211
KW  - Purines
KW  - 0
KW  - Teratogens
KW  - RNA
KW  - 63231-63-0
KW  - Nitrous Oxide
KW  - K50XQU1029
KW  - Index Medicus
KW  - Rats
KW  - Protein Biosynthesis
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Transcription, Genetic -- drug effects
KW  - Mice
KW  - Organ Culture Techniques
KW  - Female
KW  - DNA Replication -- drug effects
KW  - RNA -- biosynthesis
KW  - Pregnancy
KW  - Purines -- metabolism
KW  - Nitrous Oxide -- toxicity
KW  - Embryo, Mammalian -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-26
N1  - Date created - 1988-08-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Direct sampling of organic solvents in expired breath with a new solid sorbent sampling device.
AN  - 78325831; 3393884
JF  - Scandinavian journal of work, environment & health
AU  - Glaser, R A
AU  - Arnold, J E
AU  - Shulman, S A
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 63
EP  - 65
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Air Pollutants
KW  - 0
KW  - Solvents
KW  - Xylenes
KW  - 3-xylene
KW  - O9XS864HTE
KW  - Index Medicus
KW  - Humans
KW  - Adult
KW  - Xylenes -- analysis
KW  - Male
KW  - Solvents -- analysis
KW  - Air Pollutants -- analysis
KW  - Breath Tests -- instrumentation
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Direct+sampling+of+organic+solvents+in+expired+breath+with+a+new+solid+sorbent+sampling+device.&rft.au=Glaser%2C+R+A%3BArnold%2C+J+E%3BShulman%2C+S+A&rft.aulast=Glaser&rft.aufirst=R&rft.date=1988-01-01&rft.volume=14+Suppl+1&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Leading work-related diseases and injuries.
AN  - 78322525; 3393880
JF  - Scandinavian journal of work, environment & health
AU  - Millar, J D
AD  - National Institute for Occupational Safety and Health, Atlanta, Georgia.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 5
EP  - 6
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Wounds and Injuries -- epidemiology
KW  - Occupational Diseases -- prevention & control
KW  - Occupational Diseases -- epidemiology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Leading+work-related+diseases+and+injuries.&rft.au=Millar%2C+J+D&rft.aulast=Millar&rft.aufirst=J&rft.date=1988-01-01&rft.volume=14+Suppl+1&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Sentinel event notification system for occupational risks.
AN  - 78322460; 3393863
AB  - Mandates for provider reporting systems have existed in a number of states for many years, but due to various shortcomings the potential for targeted surveillance of occupational illness and injury has not been realized. To achieve a more uniform, active approach to provider reporting, SENSOR will be created as a cooperative state-federal effort designed to develop local capability for the recognition, reporting, follow-up, and prevention of selected occupational disorders. To demonstrate the feasibility of this approach, NIOSH funded a small number of SENSOR projects in 1987. Ultimately, joint state-federal support will be essential to maintain SENSOR activity within a state. SENSOR should not be viewed as the sole approach to the surveillance of occupational illness and injury. Other approaches to the identification of cases of occupational illness or injury and to monitoring the trends of occurrence of these disorders have been developed by NIOSH and various states, and they will continue to function.
JF  - Scandinavian journal of work, environment & health
AU  - Baker, E L
AD  - National Institute for Occupational Safety and Health, Atlanta, Georgia.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 110
EP  - 112
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Index Medicus
KW  - United States
KW  - Evaluation Studies as Topic
KW  - Humans
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Occupational Diseases -- prevention & control
KW  - Population Surveillance
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Development of an air sampling method based on the reactive properties of a contaminant.
AN  - 78321893; 3393873
JF  - Scandinavian journal of work, environment & health
AU  - Herrick, R F
AU  - Smith, T J
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 31
EP  - 32
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Aerosols
KW  - 0
KW  - Air Pollutants, Occupational
KW  - Epoxy Compounds
KW  - Ethers, Cyclic
KW  - Index Medicus
KW  - Paint
KW  - Epoxy Compounds -- analysis
KW  - Aerosols -- analysis
KW  - Ethers, Cyclic -- analysis
KW  - Air Pollutants, Occupational -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Laboratory animal allergies. Use of the radioallergosorbent test inhibition assay to monitor airborne allergen levels.
AN  - 78321325; 3393889
JF  - Scandinavian journal of work, environment & health
AU  - Lewis, D M
AU  - Bledsoe, T A
AU  - Dement, J M
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 74
EP  - 76
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Allergens
KW  - Index Medicus
KW  - Radioallergosorbent Test
KW  - Animals
KW  - Urine -- immunology
KW  - Humans
KW  - Epithelium -- immunology
KW  - Rats -- immunology
KW  - Animals, Laboratory -- immunology
KW  - Air Pollutants, Occupational -- analysis
KW  - Allergens -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Laboratory+animal+allergies.+Use+of+the+radioallergosorbent+test+inhibition+assay+to+monitor+airborne+allergen+levels.&rft.au=Lewis%2C+D+M%3BBledsoe%2C+T+A%3BDement%2C+J+M&rft.aulast=Lewis&rft.aufirst=D&rft.date=1988-01-01&rft.volume=14+Suppl+1&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Quantitation of airborne endotoxin levels in various occupational environments.
AN  - 78320837; 3393888
JF  - Scandinavian journal of work, environment & health
AU  - Olenchock, S A
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 72
EP  - 73
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Endotoxins
KW  - Index Medicus
KW  - Agriculture
KW  - Air Pollutants, Occupational -- analysis
KW  - Endotoxins -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Exposure to job stress--a new psychometric instrument.
AN  - 78320759; 3393871
JF  - Scandinavian journal of work, environment & health
AU  - Hurrell, J J
AU  - McLaney, M A
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 27
EP  - 28
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Index Medicus
KW  - Canada
KW  - Nursing
KW  - Humans
KW  - Stress, Psychological -- etiology
KW  - Psychometrics -- methods
KW  - Occupational Diseases -- psychology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78320759?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Exposure+to+job+stress--a+new+psychometric+instrument.&rft.au=Hurrell%2C+J+J%3BMcLaney%2C+M+A&rft.aulast=Hurrell&rft.aufirst=J&rft.date=1988-01-01&rft.volume=14+Suppl+1&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Development of a model for use in estimating exposure to ethylene oxide in a retrospective cohort mortality study.
AN  - 78316738; 3393872
JF  - Scandinavian journal of work, environment & health
AU  - Greife, A L
AU  - Hornung, R W
AU  - Stayner, L G
AU  - Steenland, K N
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 29
EP  - 30
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Ethylene Oxide
KW  - JJH7GNN18P
KW  - Index Medicus
KW  - Regression Analysis
KW  - Epidemiologic Methods
KW  - Retrospective Studies
KW  - Environmental Exposure
KW  - Models, Theoretical
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Fatal occupational injuries in the United States in 1980-1984. Results of the first national census of traumatic occupational fatalities.
AN  - 78314812; 3393894
JF  - Scandinavian journal of work, environment & health
AU  - Stout-Wiegand, N
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 90
EP  - 92
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Index Medicus
KW  - United States
KW  - Sex Factors
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Occupations
KW  - Male
KW  - Female
KW  - Wounds and Injuries -- etiology
KW  - Accidents, Occupational
KW  - Wounds and Injuries -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Effect of engineering controls and work practices in reducing ethylene-oxide exposure during the sterilization of hospital supplies.
AN  - 78314679; 3393877
JF  - Scandinavian journal of work, environment & health
AU  - Elliott, L
AU  - Mortimer, V
AU  - Ringenburg, V
AU  - Kercher, S
AU  - O'Brien, D
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 40
EP  - 42
VL  - 14 Suppl 1
SN  - 0355-3140, 0355-3140
KW  - Ethylene Oxide
KW  - JJH7GNN18P
KW  - Index Medicus
KW  - Environmental Exposure
KW  - Environmental Monitoring
KW  - Engineering
KW  - Personnel, Hospital
KW  - Sterilization -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-18
N1  - Date created - 1988-08-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - A retrospective cohort mortality study of workers exposed to formaldehyde in the garment industry.
AN  - 78298459; 3389362
AB  - In order to assess the possible human carcinogenicity of formaldehyde we conducted a retrospective cohort mortality study of workers exposed for at least three months to formaldehyde in three garment facilities which produced permanent press garments. A total of 11,030 workers contributing 188,025 person-years were included in the study. Vital status was successfully ascertained through 1982 for over 96% of the cohort. The average (TWA) formaldehyde exposure at the three plants monitored in 1981 and 1984 by NIOSH was 0.15 ppm but past exposures may have been substantially higher. In general, mortality from nonmalignant causes was less than expected. A statistically significant excess in mortality from cancers of the buccal cavity (SMR = 343) and connective tissue (SMR = 364) was observed. Statistically nonsignificant excesses in mortality were observed for cancers of the trachea, bronchus and lung (SMR = 114), pharynx (SMR = 112), bladder (SMR = 145), leukemia and aleukemia (SMR = 113), and other lymphopoietic neoplasms (SMR = 170). Mortality from cancers of the trachea, bronchus and lung was inversely related to duration of exposure and latency. In contrast, mortality from cancers of the buccal cavity, leukemias, and other lymphopoietic neoplasms increased with duration of formaldehyde exposure and/or latency. These neoplasms also were found to be highest among workers first exposed during a time period of high potential formaldehyde exposures in this industry (1955-1962). However, it should be recognized that these findings are based on relatively small numbers and that confounding by other factors may still exist. The results from this investigation, although far from conclusive, do provide evidence of a possible relationship between formaldehyde exposure and the development of upper respiratory cancers (buccal), leukemias, and other lymphopoietic neoplasms in humans.
JF  - American journal of industrial medicine
AU  - Stayner, L T
AU  - Elliott, L
AU  - Blade, L
AU  - Keenlyside, R
AU  - Halperin, W
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati OH 45226.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 667
EP  - 681
VL  - 13
IS  - 6
SN  - 0271-3586, 0271-3586
KW  - Formaldehyde
KW  - 1HG84L3525
KW  - Index Medicus
KW  - United States
KW  - Risk
KW  - Humans
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Neoplasms -- mortality
KW  - Neoplasms -- chemically induced
KW  - Formaldehyde -- adverse effects
KW  - Textile Industry
KW  - Occupational Diseases -- chemically induced
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-09
N1  - Date created - 1988-08-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Prevention of occupational skin disease through use of chemical protective gloves.
AN  - 78270258; 2968209
AB  - Selection of chemical protective gloves for use against industrial liquids in the controlled workplace is accomplished by risk analysis, in which the appropriate physical and chemical glove properties needed by the worker to perform the job are determined. Candidate protective gloves are then subjected to chemical permeation testing. Three representative case studies illustrate risk analysis and glove selection.
JF  - Dermatologic clinics
AU  - Berardinelli, S P
AD  - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 115
EP  - 119
VL  - 6
IS  - 1
SN  - 0733-8635, 0733-8635
KW  - Irritants
KW  - 0
KW  - Rubber
KW  - 9006-04-6
KW  - Sodium Cyanide
KW  - O5DDB9Z95G
KW  - Index Medicus
KW  - Permeability
KW  - Sodium Cyanide -- poisoning
KW  - Skin
KW  - Dermatitis, Contact -- prevention & control
KW  - Chemistry, Physical
KW  - Risk Factors
KW  - Humans
KW  - Gloves, Surgical
KW  - Chemical Phenomena
KW  - Irritants -- adverse effects
KW  - Male
KW  - Protective Clothing
KW  - Dermatitis, Occupational -- prevention & control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-04
N1  - Date created - 1988-08-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Interlaboratory evaluation of the C3H/10T1/2 cell transformation assay.
AN  - 78269654; 3383839
AB  - The C3H/10T1/2 transformation assay was evaluated for its responsiveness and interlaboratory reproducibility. Two laboratories participated in this study and tested a series of 46 chemicals. The majority of these chemicals were tested under code. Of the 46 chemicals tested, seven were determined to be active in both laboratories, and 14 were determined to be inactive. When the total number of chemicals is adjusted for assays considered "no test" in either one or both laboratories as well as for tests of chemicals yielding positive results in only one laboratory, reproducible responses were obtained for 21/35, or 60%, of the chemicals tested.
JF  - Environmental and molecular mutagenesis
AU  - Dunkel, V C
AU  - Schechtman, L M
AU  - Tu, A S
AU  - Sivak, A
AU  - Lubet, R A
AU  - Cameron, T P
AD  - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 21
EP  - 31
VL  - 12
IS  - 1
SN  - 0893-6692, 0893-6692
KW  - Index Medicus
KW  - Animals
KW  - Mice, Inbred C3H -- embryology
KW  - Mice
KW  - Cell Line
KW  - Fibroblasts -- drug effects
KW  - Fibroblasts -- pathology
KW  - Cell Transformation, Neoplastic -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-05
N1  - Date created - 1988-08-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Effects of methionine and other sulfur compounds on drug conjugations.
AN  - 78263266; 3289055
JF  - Pharmacology & therapeutics
AU  - Reicks, M
AU  - Hathcock, J N
AD  - Food and Drug Administration, Division of Nutrition, Washington, DC 20204.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 67
EP  - 79
VL  - 37
IS  - 1
SN  - 0163-7258, 0163-7258
KW  - Amino Acids, Sulfur
KW  - 0
KW  - Pharmaceutical Preparations
KW  - Methionine
KW  - AE28F7PNPL
KW  - Index Medicus
KW  - Humans
KW  - Inactivation, Metabolic -- drug effects
KW  - Pharmaceutical Preparations -- metabolism
KW  - Methionine -- pharmacology
KW  - Amino Acids, Sulfur -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-26
N1  - Date created - 1988-07-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Organic solvent neurotoxicity.
AN  - 78249189; 3288233
JF  - Annual review of public health
AU  - Baker, E L
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia 30333.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 223
EP  - 232
VL  - 9
SN  - 0163-7525, 0163-7525
KW  - Solvents
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Epidemiologic Methods
KW  - Humans
KW  - Substance-Related Disorders -- etiology
KW  - Absorption
KW  - Solvents -- toxicity
KW  - Solvents -- pharmacokinetics
KW  - Nervous System -- drug effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+public+health&rft.atitle=Organic+solvent+neurotoxicity.&rft.au=Baker%2C+E+L&rft.aulast=Baker&rft.aufirst=E&rft.date=1988-01-01&rft.volume=9&rft.issue=&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+public+health&rft.issn=01637525&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-19
N1  - Date created - 1988-07-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Erratum In:
Annu Rev Public Health 1989;10:following vii
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Risk assessment: short-term exposure at various ages.
AN  - 78199826; 3365217
JF  - Basic life sciences
AU  - Gaylor, D W
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 173
EP  - 176
VL  - 43
SN  - 0090-5542, 0090-5542
KW  - Carcinogens, Environmental
KW  - 0
KW  - Index Medicus
KW  - Age Factors
KW  - Dose-Response Relationship, Drug
KW  - Risk Factors
KW  - Humans
KW  - Time Factors
KW  - Models, Biological
KW  - Carcinogens, Environmental -- adverse effects
KW  - Neoplasms -- chemically induced
KW  - Neoplasms -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Risk+assessment%3A+short-term+exposure+at+various+ages.&rft.au=Gaylor%2C+D+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=1988-01-01&rft.volume=43&rft.issue=&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-03
N1  - Date created - 1988-06-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Risk assessment: extrapolation to individual risk.
AN  - 78198898; 3365221
JF  - Basic life sciences
AU  - Kimbrough, R D
AU  - Grandjean, P A
AD  - Centers for Disease Control, U. S. Department of Health and Human Services, Atlanta, Georgia 30333.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 245
EP  - 253
VL  - 43
SN  - 0090-5542, 0090-5542
KW  - Environmental Pollutants
KW  - 0
KW  - Index Medicus
KW  - Probability
KW  - Policy Making
KW  - Risk Factors
KW  - Humans
KW  - Environmental Pollutants -- adverse effects
KW  - Phenotype
KW  - Genetic Variation
KW  - Environmental Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78198898?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Risk+assessment%3A+extrapolation+to+individual+risk.&rft.au=Kimbrough%2C+R+D%3BGrandjean%2C+P+A&rft.aulast=Kimbrough&rft.aufirst=R&rft.date=1988-01-01&rft.volume=43&rft.issue=&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-03
N1  - Date created - 1988-06-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Cause-specific mortality among male textile workers in Rhode Island.
AN  - 78198701; 3364422
AB  - Cause-specific mortality patterns among male textile workers in Rhode Island who died during the period 1968-1978 were examined using the proportionate mortality ratio (PMR) method. Textile worker decedents were identified by the usual occupation and industry statements on Rhode Island death certificates. A statistically significant PMR elevation was observed for nonmalignant respiratory disease (NMRD) among male textile workers (PMR = 110; Observed deaths [Obs] = 433; 95% confidence interval (CI) = 102-120). The PMRs for NMRD by specific textile occupation and by type of textile manufacturing generally exhibited the pattern expected for work-related mortality owing to textile dust exposure. High PMRs were observed among carding, lapping, and combing operatives, the decedents who probably had the highest dust exposure (PMR = 166; Obs = 24; CI = 114-243), and among operatives most likely to have worked in cotton manufacturing (PMR = 137; Obs = 47; CI = 104-179). This is the first report of excess mortality from NMRD among male textile workers in the United States. This finding is consistent with previous evidence that exposure to cotton dust can cause disabling chronic lung disease. Also noteworthy were statistically significant elevated PMRs for cancers of the rectum and esophagus among decedents who had been engaged in textile dyeing and finishing. Owing to the lack of direct information about occupational exposures and smoking habits of the decedents and uncertainties in classifying decedents by type of textile manufacturing, this investigation should be viewed as being exploratory in nature.
JF  - American journal of industrial medicine
AU  - Dubrow, R
AU  - Gute, D M
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 439
EP  - 454
VL  - 13
IS  - 4
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - Rectal Neoplasms -- mortality
KW  - Rhode Island
KW  - Epidemiologic Methods
KW  - Humans
KW  - Pneumoconiosis -- mortality
KW  - Aged
KW  - Rectal Neoplasms -- etiology
KW  - Esophageal Neoplasms -- mortality
KW  - Byssinosis -- mortality
KW  - Adult
KW  - Middle Aged
KW  - Esophageal Neoplasms -- etiology
KW  - Male
KW  - Mortality
KW  - Textile Industry
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Cause-specific+mortality+among+male+textile+workers+in+Rhode+Island.&rft.au=Dubrow%2C+R%3BGute%2C+D+M&rft.aulast=Dubrow&rft.aufirst=R&rft.date=1988-01-01&rft.volume=13&rft.issue=4&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-07
N1  - Date created - 1988-06-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Phenotypic variation within genetically homogeneous populations: responsiveness to toxicants.
AN  - 78196029; 2452629
JF  - Basic life sciences
AU  - Wolff, G L
AD  - Food and Drug Administration, Department of Health and Human Services, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 71
EP  - 79
VL  - 43
SN  - 0090-5542, 0090-5542
KW  - Environmental Pollutants
KW  - 0
KW  - Lindane
KW  - 59NEE7PCAB
KW  - Index Medicus
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Humans
KW  - Liver Neoplasms, Experimental -- chemically induced
KW  - Mice
KW  - Gene Expression Regulation
KW  - Homeostasis
KW  - Environmental Pollutants -- adverse effects
KW  - Phenotype
KW  - Genetic Variation
KW  - Diabetes Mellitus, Experimental -- genetics
KW  - Neoplasms, Experimental -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-03
N1  - Date created - 1988-06-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Use of ten gram samples of corn for determination of mycotoxins.
AN  - 78194074; 3360704
AB  - Data were gathered, during a study on the development of an automated system for the extraction, cleanup, and quantitation of mycotoxins in corn, to determine if it was scientifically sound to reduce the analytical sample size. Five, 10, and 25 g test portions were analyzed and statistically compared with 50 g test portions of the same composites for aflatoxin concentration variance. Statistical tests used to determine whether the 10 and 50 g sample sizes differed significantly showed a satisfactory observed variance ratio (Fobs) of 2.03 for computations of pooled standard deviations; paired t-test values of 0.952, 1.43, and 0.224 were computed for each of the 3 study samples. The results meet acceptable limits, since each sample's t-test result is less than the published value of the /t/, which is 1.6909 for the test conditions. The null hypothesis is retained since the sample sizes do not give significantly different values for the mean analyte concentration. The percent coefficients of variation (CVs) for all samples tested were within the expected range. In addition, the variance due to sample mixing was evaluated using radioisotope-labeled materials, yielding an acceptable CV of 22.2%. The variance due to the assay procedure was also evaluated and showed an aflatoxin B, recovery of 78.9% and a CV of 11.4%. Results support the original premise that a sufficiently ground and blended sample would produce an analyte variance for a 10 g sample that was statistically comparable with that for a 50 g sample.
JF  - Journal - Association of Official Analytical Chemists
AU  - Francis, O J
AU  - Ware, G M
AU  - Carman, A S
AU  - Kirschenheuter, G P
AU  - Kuan, S S
AD  - Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122.
PY  - 1988
SP  - 41
EP  - 43
VL  - 71
IS  - 1
SN  - 0004-5756, 0004-5756
KW  - Aflatoxins
KW  - 0
KW  - Mycotoxins
KW  - Index Medicus
KW  - Aflatoxins -- analysis
KW  - Chromatography, Thin Layer
KW  - Food Contamination -- analysis
KW  - Zea mays -- analysis
KW  - Mycotoxins -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-27
N1  - Date created - 1988-05-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Study of mortality among chemical workers in the Kanawha Valley of West Virginia.
AN  - 78193115; 3284337
AB  - To assess the mortality experience of a cohort of chemical workers in the Kanawha Valley of West Virginia, 29,139 males who worked at any one of three facilities over a 39-year period were followed-up for vital status. The facilities include two chemical manufacturing plants and a research and development center. From this cohort, 5,785 men were found to have died as of the study end, December 31, 1978. This was less than the 6,148.5 men expected to have died, based upon the United States white male population (standardized mortality ratio (SMR) = 94, 95% confidence interval (CI) = 92-96). Eighty-six specific causes of death were examined. Statistically significant increased deaths were observed for two causes; cancers of the liver (not specified as primary or secondary) (SMR = 174; CI = 102-280) and lympho- and reticulosarcoma (SMR = 140; CI = 104-187). When all biliary and liver cancer was examined by duration and time since initial employment, the SMR for those who worked at least 25 years and whose deaths occurred 30 years or more after first employment was 301 (95% confidence limit = 168-497). The identification and follow-up of this complete cohort provides the basis for future study of subcohorts with specific chemical and process exposures and case control studies of specific causes of death.
JF  - American journal of industrial medicine
AU  - Rinsky, R A
AU  - Ott, G
AU  - Ward, E
AU  - Greenberg, H
AU  - Halperin, W
AU  - Leet, T
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, Ohio 45226.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 429
EP  - 438
VL  - 13
IS  - 4
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - Lymphoma, Non-Hodgkin -- mortality
KW  - Lymphoma, Large B-Cell, Diffuse -- mortality
KW  - Humans
KW  - Liver Neoplasms -- mortality
KW  - Adult
KW  - Liver Neoplasms -- chemically induced
KW  - Aged
KW  - Middle Aged
KW  - Lymphoma, Non-Hodgkin -- chemically induced
KW  - Lymphoma, Large B-Cell, Diffuse -- chemically induced
KW  - Male
KW  - Female
KW  - West Virginia
KW  - Mortality
KW  - Chemical Industry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-07
N1  - Date created - 1988-06-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Metabolism of 1-, 3-, and 6-nitrobenzo[a]pyrene by intestinal microflora.
AN  - 78171977; 3361619
AB  - The compounds 1-, 3-, and 6-nitrobenzo[a]pyrene (nitro-BaP) are environmental pollutants and have been shown to be potent bacterial mutagens. The anaerobic metabolism of these isomeric nitro-BaPs was investigated by the incubation of rat intestinal microflora with each isomer for 48 h. Aliquots were removed at several time intervals, extracted, fractionated by high-pressure liquid chromatography (HPLC), and the radioactivity determined. Metabolites were identified by comparison of their chromatographic, ultraviolet-visible absorption, and mass spectral properties with those of authentic standards. The order of the extent of nitroreduction for these isomers was 3-nitro-BaP greater than 6-nitro-BaP greater than 1-nitro-BaP. After 48 h of exposure, 84% of the added 3-nitro-BaP was present as 3-amino-BaP, 51% of the 6-nitro-BaP was metabolized to 6-amino-BaP, and 1-nitro-BaP was reduced to 1-amino-BaP (13%) and 1-nitro-BaP (4%). The order of the extent of microbial nitroreduction for these nitro-BaP isomers is different from the predictions based on electronic and steric hindrance effects. These results suggest that intestinal microflora nitroreductases exhibit a markedly high degree of substrate specificity toward nitro-BaPs that affects the extent of nitroreduction.
JF  - Journal of toxicology and environmental health
AU  - Richardson, K E
AU  - Fu, P P
AU  - Cerniglia, C E
AD  - National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 527
EP  - 537
VL  - 23
IS  - 4
SN  - 0098-4108, 0098-4108
KW  - Benzopyrenes
KW  - 0
KW  - Tritium
KW  - 10028-17-8
KW  - 6-nitrobenzo(a)pyrene
KW  - 63041-90-7
KW  - 3-nitrobenzo(a)pyrene
KW  - 70021-98-6
KW  - 1-nitrobenzo(a)pyrene
KW  - 70021-99-7
KW  - Index Medicus
KW  - Rats
KW  - Mass Spectrometry
KW  - Animals
KW  - Culture Techniques
KW  - Female
KW  - Chromatography, High Pressure Liquid
KW  - Benzopyrenes -- metabolism
KW  - Intestines -- microbiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-27
N1  - Date created - 1988-05-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - A retrospective cohort mortality study of males mining and milling attapulgite clay.
AN  - 78169072; 3354582
AB  - To evaluate the possible health effects of occupational exposure to a nonasbestos mineral fiber, a cohort of 2,302 males employed for at least 1 month between 1940 and 1975 at an attapulgite (clay fiber) mining and milling facility was followed through 1975. A significant deficit of mortality (SMR = 43, 90% CI 23-76) from nonmalignant respiratory disease (NMRD) was observed for the cohort based on age-, calendar year-, and race-specific rates for U.S. males. A marked deficit of NMRD was seen regardless of presumed dust exposure level, induction-latency period, or duration employed. A statistically significant excess of mortality from lung cancer was observed among whites (SMR = 193, 90% CI 121-293), but a deficit occurred among nonwhites (SMR = 53, 90% CI 21-112). Lung cancer risk in either race was not altered substantially with presumed dust exposure level, induction-latency period, or duration employed with one exception-those employed for at least 5 years in high-exposure-level jobs.
JF  - American journal of industrial medicine
AU  - Waxweiler, R J
AU  - Zumwalde, R D
AU  - Ness, G O
AU  - Brown, D P
AD  - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 305
EP  - 315
VL  - 13
IS  - 3
SN  - 0271-3586, 0271-3586
KW  - Dust
KW  - 0
KW  - Magnesium Compounds
KW  - Silicon Compounds
KW  - Magnesium
KW  - I38ZP9992A
KW  - attapulgite
KW  - U6V729APAM
KW  - Silicon
KW  - Z4152N8IUI
KW  - Index Medicus
KW  - Risk Factors
KW  - Humans
KW  - Liver Neoplasms -- mortality
KW  - Retrospective Studies
KW  - Gastrointestinal Neoplasms -- mortality
KW  - Male
KW  - Lung Neoplasms -- mortality
KW  - Mining
KW  - Magnesium -- adverse effects
KW  - Dust -- adverse effects
KW  - Silicon -- adverse effects
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-29
N1  - Date created - 1988-04-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Neurochemical, but not behavioral, deviations in the offspring of rats following prenatal or paternal inhalation exposure to ethanol.
AN  - 78161634; 2895419
AB  - In addition to its widespread social use, ethanol is used extensively as an industrial solvent. Inhalation exposures to ethanol which produce narcosis in maternal rats are not teratogenic. The present study sought to extend the previous research by including offspring from paternal exposures, and testing for behavioral disorders in the offspring following maternal or paternal exposures. Groups of 18 male (approximately 450 g) and 15 female (200-300 g) Sprague-Dawley rats were exposed 7 hours/day for six weeks or throughout gestation to 16000, 10000, or 0 ppm ethanol by inhalation and then mated with untreated rats. Litters were culled to 4 males and 4 females, and were fostered within 16 hours after birth to untreated dams which had delivered their litters within 48 hours previously. Offspring from paternally or maternally exposed animals performed as well as controls on days 10-90 in tests of neuromotor coordination (ascent on a wire mesh screen, rotorod), activity levels (open field, modified-automated open field, and running wheel), and learning ability (avoidance conditioning and operant conditioning). In addition, brains of 10 21-day-old pups were analyzed for neurochemical differences from controls in concentrations of protein and the neurotransmitters acetylcholine, dopamine, norepinephrine, 5-hydroxytryptamine, substance P, Met-enkephalin, and beta-endorphin. Levels of acetylcholine, dopamine, substance P, and beta-endorphin were essentially unchanged in the offspring of rats exposed to ethanol. Complex, but significant changes in levels of norepinephrine occurred only in paternally exposed offspring. 5-Hydroxytryptamine levels were reduced in the cerebrum, and Met-enkephalin levels were increased in all brain regions of offspring from both maternally and paternally exposed rats.
JF  - Neurotoxicology and teratology
AU  - Nelson, B K
AU  - Brightwell, W S
AU  - MacKenzie-Taylor, D R
AU  - Burg, J R
AU  - Massari, V J
AD  - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
PY  - 1988
SP  - 15
EP  - 22
VL  - 10
IS  - 1
SN  - 0892-0362, 0892-0362
KW  - Neuropeptides
KW  - 0
KW  - Neurotransmitter Agents
KW  - Ethanol
KW  - 3K9958V90M
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Neuropeptides -- analysis
KW  - Neurotransmitter Agents -- analysis
KW  - Body Weight -- drug effects
KW  - Learning -- drug effects
KW  - Motor Activity -- drug effects
KW  - Administration, Inhalation
KW  - Male
KW  - Female
KW  - Pregnancy
KW  - Behavior, Animal -- drug effects
KW  - Fetus -- drug effects
KW  - Brain Chemistry -- drug effects
KW  - Ethanol -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-04
N1  - Date created - 1988-05-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Surveillance of occupational skin disease using the Supplementary Data System.
AN  - 78159395; 2965512
AB  - The utility of the Supplementary Data System (SDS) compiled by the Bureau of Labor Statistics (BLS) in conducting surveillance of occupational skin disease was evaluated by examining 14,703 workers' compensation cases reported to the SDS for the year 1981. Combined with state employment denominators obtained from the BLS Employment and Earnings Program, rates of illness (cases of dermatitis/10,000 employed) calculated for eight major industrial divisions varied significantly according to the criteria used for reporting cases. Despite quantitative variations in the rate of skin disease that depended on specific reporting criteria, the relative ranking of the major industrial divisions remained unchanged, with highest rates of skin disease consistently found in three major industry divisions: agriculture, manufacturing, and construction. This ranking of major industry divisions by rate of dermatitis corresponded extremely well with rankings generated from the 1981 Annual Survey (Spearman rank correlation = .98, p less than .01). At the two-digit level of the Standard Industrial Classification, the rankings based on the SDS had a 77% rank correlation with those from the Annual Survey. Two-digit SIC codes identified from the top 10 in both sets of rankings included crop and livestock production from the agricultural division and leather products, food products, rubber and plastic products from the manufacturing division.
JF  - American journal of industrial medicine
AU  - O'Malley, M
AU  - Thun, M
AU  - Morrison, J
AU  - Mathias, C G
AU  - Halperin, W E
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 291
EP  - 299
VL  - 13
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Government Agencies
KW  - Workers' Compensation
KW  - Occupations
KW  - Information Systems
KW  - Dermatitis, Occupational -- epidemiology
KW  - Population Surveillance
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-22
N1  - Date created - 1988-04-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Short duration exposures to organic solvents: the relationship between neurobehavioral test results and other indicators.
AN  - 78152458; 3352568
AB  - Short duration exposure to solvents at even low concentrations can induce signs of mild toxicity such as mucous membrane irritation, tearing, nasal irritation, headache, and nausea. These irritant effects are often used as warning properties for potential solvent toxicities and have frequently been classified in the literature as pre-narcotic effects. With higher exposures the toxic effects are more pronounced and can include intoxication, incoordination, exhilaration, sleepiness, stupor, and the beginning stages of anesthesia. Collectively these effects are taken as indicators of narcosis. Offering recommendations for safe exposure limits for these shorter term exposures is made difficult because, (1) the mild toxic effects are often reported subjectively and tolerance usually develops, (2) the solvent concentration(s) cannot be documented in all cases, and (3) the effects are reversible when individuals are removed from exposure. Laboratory experiments involving controlled exposures to solvents using neurobehavioral performance tests represent one form of investigation that can provide meaningful information in this instance. The results can be viewed in two ways with reference to issues of safe exposure limits. One is to ensure that performance functions that can compromise safety are not affected by the exposure limits prescribed. The second is to consider performance changes due to short-term exposures as possible precursors of similar but more severe effects given longer term exposures. Thus, setting exposure limits to protect against these performance changes could possibly prevent the development of more serious cases of chronic solvent neurotoxicity. This paper compares solvent concentrations from short-duration exposure studies using neurobehavioral tests with the concentrations producing irritant and narcotic effects, as documented by the two main standards recommending bodies, the National Institute for Occupational Safety and Health and the American Conference of Governmental Industrial Hygienists. Comparisons are also made with the regulatory exposure limits established by the Occupational Safety and Health Administration. In general, the neurobehavioral changes which occur following short-duration exposures are reported at concentrations between those which produce irritant effects and narcosis. For the chemicals which have been tested, the performance changes measured by the present day neurobehavioral tests in use rarely occur at or below those limits recommended by the standards recommending bodies.
JF  - Neurotoxicology and teratology
AU  - Dick, R B
AD  - National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226.
PY  - 1988
SP  - 39
EP  - 50
VL  - 10
IS  - 1
SN  - 0892-0362, 0892-0362
KW  - Irritants
KW  - 0
KW  - Narcotics
KW  - Solvents
KW  - Index Medicus
KW  - Maximum Allowable Concentration
KW  - Irritants -- toxicity
KW  - Humans
KW  - Narcotics -- toxicity
KW  - Environmental Exposure
KW  - Time Factors
KW  - Solvents -- toxicity
KW  - Psychomotor Performance -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-05-04
N1  - Date created - 1988-05-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Summary of "Proposed national strategies for the prevention of leading work-related diseases and injuries, Part 1".
AN  - 78151494; 3354576
AB  - Strategies for the prevention of leading occupational health problems have been proposed by the National Institute for Occupational Safety and Health (NIOSH). NIOSH prepared these strategies following publication in 1983 of its suggested list of ten leading work-related diseases and injuries. At a national symposium in 1985, occupational health experts from academia, organized labor, management, professional associations, and voluntary organizations conducted an in-depth evaluation of the prevention strategies for the first five conditions on the list: occupational lung diseases, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, and occupational cardiovascular diseases. The strategies were then revised to incorporate improvements suggested at the symposium and were published in booklet form. A summary of the revised strategies is provided.
JF  - American journal of industrial medicine
AU  - Millar, J D
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, GA 30333.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 223
EP  - 240
VL  - 13
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Safety
KW  - Neoplasms -- prevention & control
KW  - Musculoskeletal System -- injuries
KW  - Health Policy
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Lung Diseases -- prevention & control
KW  - Cardiovascular Diseases -- prevention & control
KW  - Accidents, Occupational -- prevention & control
KW  - Occupational Diseases -- prevention & control
KW  - Wounds and Injuries -- prevention & control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-22
N1  - Date created - 1988-04-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - DNA homology and immunological cross-reactivity between Aeromonas hydrophila cytotonic toxin and cholera toxin.
AN  - 78130049; 2830300
AB  - DNA colony hybridization with three 18- to 20-base-long synthetic oligonucleotide probes for cholera toxin (CT) was used to screen 12 clinical isolates of Aeromonas hydrophila. Under stringent hybridizing (overnight at 40 degrees C) and washing (1 h at 50 degrees C) conditions, nine strains reacted with the 32P-labeled CT probes. Concentrated (10x) cell-free supernatants or lysates from eight cultures, heated at 56 degrees C for 20 min, produced cytotonic effects in Y-1 mouse adrenal cells and Chinese hamster ovary (CHO) cells and caused a 1.5- to 22-fold increase in production of cyclic AMP in CHO cells. Preincubation with anti-CT reduced the CHO cell titer of cell lysates by 10-fold. In the GM1 ganglioside enzyme-linked immunosorbent assay, heated supernatants and lysates gave readings equivalent to 3.5 to 100 ng of CT. Three proteins with molecular weights of 89,900, 37,000, and 11,000 reacted with anti-CT on immunoblots of cell lysates from sodium dodecyl sulfate-polyacrylamide gels. These results suggest that there is DNA homology and immunological cross-reactivity between CT and the A. hydrophila cytotonic toxin.
JF  - Journal of clinical microbiology
AU  - Schultz, A J
AU  - McCardell, B A
AD  - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 57
EP  - 61
VL  - 26
IS  - 1
SN  - 0095-1137, 0095-1137
KW  - Bacterial Toxins
KW  - 0
KW  - Cytotoxins
KW  - DNA, Bacterial
KW  - Cholera Toxin
KW  - 9012-63-9
KW  - Cyclic AMP
KW  - E0399OZS9N
KW  - Index Medicus
KW  - Sequence Homology, Nucleic Acid
KW  - DNA, Bacterial -- genetics
KW  - Cyclic AMP -- metabolism
KW  - Nucleic Acid Hybridization
KW  - Cross Reactions
KW  - Bacterial Toxins -- genetics
KW  - Cholera Toxin -- immunology
KW  - Aeromonas
KW  - Cytotoxins -- toxicity
KW  - Cholera Toxin -- genetics
KW  - Cytotoxins -- immunology
KW  - Cytotoxins -- genetics
KW  - Cholera Toxin -- toxicity
KW  - Bacterial Toxins -- toxicity
KW  - Bacterial Toxins -- immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-07
N1  - Date created - 1988-04-07
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 [5963888]
J Med Microbiol. 1987 Mar;23(2):179-86 [3560188]
J Med Microbiol. 1975 Feb;8(1):195-8 [1092866]
Acta Pathol Microbiol Scand B. 1976 Apr;84(2):112-4 [1274594]
Infect Immun. 1978 Sep;21(3):1036-9 [361573]
Anal Biochem. 1981 Apr;112(2):195-203 [6266278]
Clin Exp Immunol. 1982 Jan;47(1):34-42 [7047024]
Pharmacol Ther. 1981;15(3):339-54 [7048346]
Proc Natl Acad Sci U S A. 1983 Jan;80(1):278-82 [6572002]
J Biol Chem. 1983 Nov 25;258(22):13722-6 [6315707]
Plasmid. 1983 Nov;10(3):296-8 [6657780]
Infect Immun. 1984 Oct;46(1):122-7 [6480102]
Infect Immun. 1984 Nov;46(2):435-41 [6500697]
Am J Trop Med Hyg. 1985 May;34(3):547-54 [3890578]
Infect Immun. 1985 Oct;50(1):322-3 [4044041]
Infection. 1985 Jul-Aug;13(4):169-73 [3899944]
Can J Microbiol. 1986 May;32(5):395-401 [3719459]
J Clin Microbiol. 1986 Oct;24(4):661-4 [3771756]
J Bacteriol. 1987 Mar;169(3):1352-7 [3546273]
J Med Microbiol. 1987 Mar;23(2):171-7 [3104592]
Infect Immun. 1974 Aug;10(2):320-7 [4368545]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Metabolism of 6-nitrochrysene by intestinal microflora.
AN  - 78122919; 3345078
AB  - Since bacterial nitroreduction may play a critical role in the activation of nitropolycyclic aromatic hydrocarbons, we have used batch and semicontinuous culture systems to determine the ability of intestinal microflora to metabolize the carcinogen 6-nitrochrysene (6-NC). 6-NC was metabolized by the intestinal microflora present in the semicontinuous culture system to 6-aminochrysene (6-AC), N-formyl-6-aminochrysene (6-FAC), and 6-nitrosochrysene (6-NOC). These metabolites were isolated and identified by high-performance liquid chromatography, mass spectrometry, and UV-visible spectrophotometry and compared with authentic compounds. Almost all of the 6-NC was metabolized after 10 days. Nitroreduction of 6-NC to 6-AC was rapid; the 6-AC concentration reached a maximum at 48 h. The ratio of the formation of 6-AC to 6-FAC to 6-NOC at 48 h was 93.4:6.3:0.3. Interestingly, compared with results in the semicontinuous culture system, the only metabolite detected in the batch studies was 6-AC. The rate of nitroreduction differed among human, rat, and mouse intestinal microflora, with human intestinal microflora metabolizing 6-NC to the greatest extent. Since 6-AC has been shown to be carcinogenic in mice and since nitroso derivatives of other nitropolycyclic aromatic hydrocarbons are biologically active, our results suggest that the intestinal microflora has the enzymatic capacity to generate genotoxic compounds and may play an important role in the carcinogenicity of 6-NC.
JF  - Applied and environmental microbiology
AU  - Manning, B W
AU  - Campbell, W L
AU  - Franklin, W
AU  - Delclos, K B
AU  - Cerniglia, C E
AD  - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 197
EP  - 203
VL  - 54
IS  - 1
SN  - 0099-2240, 0099-2240
KW  - Benzopyrenes
KW  - 0
KW  - Chrysenes
KW  - Phenanthrenes
KW  - Pyrenes
KW  - 6-nitrobenzo(a)pyrene
KW  - 63041-90-7
KW  - 6-nitrochrysene
KW  - 82ZK83O33Y
KW  - 1-nitropyrene
KW  - TD1665I8Q4
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Humans
KW  - Pyrenes -- metabolism
KW  - Adult
KW  - Mice
KW  - Benzopyrenes -- metabolism
KW  - Mice, Inbred BALB C
KW  - Male
KW  - Female
KW  - Bacteria -- metabolism
KW  - Phenanthrenes -- metabolism
KW  - Chrysenes -- metabolism
KW  - Intestines -- microbiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-04
N1  - Date created - 1988-04-04
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Mutat Res. 1986 Sep;175(1):11-6 [3528841]
Carcinogenesis. 1986 Aug;7(8):1317-22 [3731386]
Nature. 1969 Mar 15;221(5185):1063-4 [4304485]
Pharmacol Rev. 1973 Dec;25(4):451-523 [4587548]
Appl Microbiol. 1974 May;27(5):961-79 [4598229]
Eur J Cancer. 1975 May;11(5):327-34 [1171763]
Clin Chim Acta. 1977 Jul 15;78(2):243-50 [884859]
CRC Crit Rev Food Sci Nutr. 1977 Jan;8(3):229-336 [338249]
Annu Rev Pharmacol Toxicol. 1978;18:523-39 [348067]
Am J Clin Nutr. 1979 Oct;32(10):2094-101 [484528]
Science. 1980 Aug 29;209(4460):1037-9 [6996094]
Science. 1980 Aug 29;209(4460):1039-43 [6996095]
Mutat Res. 1981 Jul;89(3):187-96 [7022192]
Mutat Res. 1981 Jul-Sep;91(4-5):321-5 [7022203]
Carcinogenesis. 1981;2(6):559-65 [7023731]
Appl Environ Microbiol. 1981 Sep;42(3):400-7 [7027952]
Mutat Res. 1982 Mar;101(1):1-10 [6176863]
Biochem Biophys Res Commun. 1982 Apr 14;105(3):1037-43 [7046751]
Experientia. 1982 Jul 15;38(7):837-8 [6896689]
Cancer Res. 1983 Jan;43(1):192-6 [6847768]
Cancer Lett. 1982 Sep;16(3):333-7 [6295624]
Microbiol Immunol. 1982;26(11):993-1005 [7167066]
Mutat Res. 1983 Apr;114(3):217-67 [6300670]
Carcinogenesis. 1983 Aug;4(8):985-90 [6347427]
Am J Public Health. 1983 Sep;73(9):1085-8 [6192732]
Cancer Lett. 1983 Jul;19(3):311-6 [6688375]
Cancer Res. 1984 Aug;44(8):3408-13 [6378368]
J Appl Toxicol. 1981 Apr;1(2):54-60 [6206114]
Biochem Biophys Res Commun. 1984 Aug 30;123(1):262-70 [6477581]
Mutat Res. 1985 Mar;149(1):25-32 [3883150]
Carcinogenesis. 1985 May;6(5):801-3 [4006066]
Mutat Res. 1985 Jul;143(3):173-81 [3892279]
Appl Environ Microbiol. 1985 Jul;50(1):10-5 [4026284]
J Toxicol Environ Health. 1986;18(3):339-46 [3519993]
Antimicrob Agents Chemother. 1986 Jan;29(1):44-8 [3729334]
Carcinogenesis. 1987 Nov;8(11):1703-9 [3664962]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Detection of TEM-induced reciprocal translocations in F1 sons of CD-1 male mice: comparison of sequential fertility evaluation and cytogenetic analysis.
AN  - 78119048; 3345738
AB  - To determine the positive and negative classification error rates associated with the HTA in our laboratory, F1 sons of TEM-exposed CD-1 male mice were evaluated by the sequential fertility method with subsequent cytogenetic analysis. Males who sired three litters of size 10 or less when mated to primiparous females from either the B6C3F1 or the BCF1 strain were classified as partial steriles. When meiotic chromosome analyses revealed the presence of at least two cells containing multivalent figures, males were classified as translocation heterozygotes. When the fertility evaluation and the cytogenetic analysis were compared, normal fertility was observed on 5 of 83 (6.02%) translocation-bearing F1 males mated to B6C3F1 tester females and on 3 of 83 (3.61%) F1 males mated to BCF1 tester females. Thus, the false-negative error rates were 6.02% and 3.61% with these two tester strains. Multivalent figures were not observed in the meiotic chromosomes of 410 F1 males. Of these, 12 (2.93%) had reduced fertility when mated to the B6C3F1 tester strain as did 7 (1.71%) mated to the BCF1 strain. Thus, the false-positive error rates with these two tester strains were 2.93% for the B6C3F1 strain and 1.71% for the BCF1 strain. Our results indicate that non-zero error rates, both false-positive and false-negative, are associated with the sequential mating method HTA. In addition, the magnitude of these error rates was influenced not only by the tester female strain but also by the genotype of the F1 male.
JF  - Environmental and molecular mutagenesis
AU  - Morris, S M
AU  - Kodell, R L
AU  - Domon, O E
AU  - Bishop, J B
AD  - Department of Health and Human Services, Food and Drug Administration, Jefferson, Arkansas.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 215
EP  - 223
VL  - 11
IS  - 2
SN  - 0893-6692, 0893-6692
KW  - Triethylenemelamine
KW  - F7IY6HZG9D
KW  - Index Medicus
KW  - Litter Size -- drug effects
KW  - Animals
KW  - Meiosis -- drug effects
KW  - Predictive Value of Tests
KW  - Mitosis -- drug effects
KW  - Mice
KW  - Male
KW  - Female
KW  - Fertility -- drug effects
KW  - Triethylenemelamine -- toxicity
KW  - Translocation, Genetic -- drug effects
KW  - Infertility, Male -- genetics
KW  - Infertility, Male -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-20
N1  - Date created - 1988-04-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Metabolism of 2-acetylaminofluorene in the Chinese hamster ovary cell mutation assay.
AN  - 78118554; 3345736
AB  - Chinese hamster ovary (CHO) cells were exposed to 2-acetylaminofluorene (2-AAF) and 2-aminofluorene (2-AF), and several of their N-oxidized metabolites in order to study the mechanisms by which arylamides and arylamines produce mutations in mammalian cells. The number of mutations induced at the hypoxanthine-guanine phosphoribosyl transferase locus by each compound (mutants/10(6) CHO cells/nmol compound/ml) was estimated to be: N-acetoxy-2-AAF, 310; N-hydroxy-2-AF, 3; N-hydroxy-2-AAF (with and without hepatic S9 activation), 0.7; 2-AAF (with S9), 0.1; and 2-AF (with S9), 0.09. With each compound, DNA adducts were also identified and quantified, and in all cases the major adduct was N-(deoxyguanosin-8-yl)-2-AF. 2-AAF and N-hydroxy-2-AAF also formed minor amounts of N-(deoxyguanosin-8-yl)-2-AAF and 3-(deoxyguanosin-N2-yl)-2-AAF. The relationship between mutation induction and adduct formation for each of the derivatives was similar to that previously reported for N-hydroxy-2-AF. Inclusion of the deacetylase inhibitor, paraoxon, reduced the mutagenicity of 2-AAF, N-hydroxy-2-AAF and N-acetoxy-2-AAF, and the DNA adducts produced by N-acetoxy-2-AAF to background levels. Acetyl coenzyme A increased the mutations and CHO cytosol-mediated DNA binding of N-hydroxy-2-AAF, but did not substantially increase these responses from N-hydroxy-2-AF. N-Hydroxy-2-AAF was not detectably metabolized by CHO cells. Taken together, these data indicate that CHO cells metabolized N-acetoxy-2-AAF to a reactive derivative by N-deacetylation to N-acetoxy-2-AF, while N-hydroxy-2-AF reacted directly with DNA. The major pathway of N-hydroxy-2-AAF activation appeared to be an initial O-acetylation to N-acetoxy-2-AAF and this occurred to only a limited extent in the CHO cells. N-Hydroxy-2-AAF also seemed to form an additional unknown ester intermediate that gave rise to acetylated DNA adducts. The initial step in the activation of 2-AAF and 2-AF was an N-oxidation to N-hydroxy-2-AAF and N-hydroxy-2-AF, respectively. The limited O-acetylase activity in CHO cells appeared to contribute to the low sensitivity of these cells toward mutation induction by arylamines and arylamides.
JF  - Environmental and molecular mutagenesis
AU  - Heflich, R H
AU  - Djurić, Z
AU  - Zhuo, Z
AU  - Fullerton, N F
AU  - Casciano, D A
AU  - Beland, F A
AD  - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 167
EP  - 181
VL  - 11
IS  - 2
SN  - 0893-6692, 0893-6692
KW  - Fluorenes
KW  - 0
KW  - 2-aminofluorene
KW  - 3A69OS195N
KW  - Hydroxyacetylaminofluorene
KW  - 53-95-2
KW  - Acetoxyacetylaminofluorene
KW  - 6098-44-8
KW  - N-hydroxy-2-aminofluorene
KW  - 61M94X4V24
KW  - Acetyl Coenzyme A
KW  - 72-89-9
KW  - 2-Acetylaminofluorene
KW  - 9M98QLJ2DL
KW  - Paraoxon
KW  - Q9CX8P80JW
KW  - Index Medicus
KW  - Paraoxon -- pharmacology
KW  - Animals
KW  - Cytosol -- metabolism
KW  - Cricetulus
KW  - Ovary
KW  - Fluorenes -- metabolism
KW  - DNA Damage
KW  - Oxidation-Reduction
KW  - Acetylation
KW  - Mutagenicity Tests
KW  - Fluorenes -- pharmacology
KW  - Acetyl Coenzyme A -- pharmacology
KW  - Hydroxyacetylaminofluorene -- pharmacology
KW  - Acetoxyacetylaminofluorene -- metabolism
KW  - Biotransformation
KW  - Acetoxyacetylaminofluorene -- pharmacology
KW  - Cell Line
KW  - Female
KW  - Hydroxyacetylaminofluorene -- metabolism
KW  - Cricetinae
KW  - Fibroblasts -- drug effects
KW  - 2-Acetylaminofluorene -- pharmacology
KW  - 2-Acetylaminofluorene -- metabolism
KW  - Fibroblasts -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-20
N1  - Date created - 1988-04-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Farming and malignant lymphoma in Hancock County, Ohio.
AN  - 78114352; 3342184
AB  - Raised death rates have been reported for non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) among white male residents of Hancock County, Ohio, United States, for 1960-79. As a surveillance activity, to assess the possibility of workplace exposures contributing to these raised rates, a case-control study was conducted using death certificate records of white male Hancock County residents for 1958-83. There were 61 cases of NHL, 15 cases of HD, and 304 control subjects (chosen as a stratified random sample) in the study. Cases and controls were compared with respect to their usual occupation and industry statements on the death certificates, adjusting for age at death and year of death. Summary odds ratios (OR) and test-based 95% confidence intervals (CI) were calculated. NHL was associated with the occupation of farmer (OR = 1.6; CI = 0.8, 3.4; observed number of exposed cases (Obs) = 15). The association was restricted to 1958-73 (OR = 2.1; CI = 0.9, 4.8; Obs = 13). The three cases of HD among farmers occurred in a cluster in the 15-64 age range during 1958-63 (OR = 21.2). The results for occupations and industries other than farming were based on small numbers and were unremarkable. This small study adds to the growing body of reports linking farming and malignant lymphoma, particularly NHL.
JF  - British journal of industrial medicine
AU  - Dubrow, R
AU  - Paulson, J O
AU  - Indian, R W
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 25
EP  - 28
VL  - 45
IS  - 1
SN  - 0007-1072, 0007-1072
KW  - Index Medicus
KW  - Humans
KW  - Male
KW  - Ohio
KW  - Agricultural Workers' Diseases -- mortality
KW  - Lymphoma, Non-Hodgkin -- mortality
KW  - Hodgkin Disease -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-31
N1  - Date created - 1988-03-31
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Am J Epidemiol. 1976 Feb;103(2):226-35 [1251836]
JAMA. 1986 Sep 5;256(9):1141-7 [3801091]
Br J Cancer. 1981 Feb;43(2):169-76 [7470379]
J Natl Cancer Inst. 1981 Mar;66(3):461-4 [6937703]
Scand J Work Environ Health. 1980 Dec;6(4):302-5 [7233119]
Lancet. 1981 Sep 12;2(8246):579 [6116017]
Int J Cancer. 1982 Mar 15;29(3):239-47 [7040259]
JAMA. 1982 Sep 3;248(9):1073-6 [7109199]
J Natl Cancer Inst. 1984 Mar;72(3):503-4 [6583435]
J Natl Cancer Inst. 1984 Jun;72(6):1233-40 [6587145]
Arch Intern Med. 1984 Jul;144(7):1409-11 [6587835]
Leuk Res. 1984;8(4):681-9 [6471900]
J Occup Med. 1985 Aug;27(8):580-4 [3897488]
Br J Ind Med. 1986 Feb;43(2):75-83 [3753879]
Scand J Work Environ Health. 1985 Dec;11(6):397-407 [3912986]
Lancet. 1978 Apr 29;1(8070):942 [76881]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats.
AN  - 78096773; 3124293
AB  - Loss of body weight, cardiomyopathy, and nephropathy were the main toxic manifestations found when male spontaneously hypertensive rats (SHR) and genetically related Wistar-Kyoto (WKY) rats were given 1 mg/kg doxorubicin iv once a week for 12 weeks. Each of these alterations was more severe in SHR. The most profound effects on body weight were observed from the 7th to the 12th week of dosing. During this period the body weight of SHR declined to preinjection control levels. Weight loss also occurred in WKY given doxorubicin, but was not as profound. Pretreatment with 25 mg/kg ICRF-187 ip attenuated the doxorubicin-induced loss in body weight in both types of animals. The frequency and severity of cardiac and renal lesions were graded on a score of 0 to 4. Alterations were found in hearts of all SHR and four of five WKY given doxorubicin alone. Cytoplasmic vacuolization and myofibrillar loss were more severe in SHR (average score, 2.6) than in WKY (average score, 1.0). At the end of the study mean arterial pressure was also decreased in SHR which had received doxorubicin alone. Pretreatment with ICRF-187 significantly attenuated the severity of the lesions in both SHR (average score, 1.0) and WKY (average score, 0); mean arterial pressure was higher in SHR treated with ICRF-187 and doxorubicin than in saline-treated SHR. Renal alterations, including glomerular vacuolization and tubular dilatation, were found in both strains of rats (average scores, 4.0 in SHR and 3.0 in WKY). ICRF-187 also reduced the severity of renal lesions (average scores, 2.0 in SHR and 1.0 in WKY). Thus, although ICRF-187 significantly alters myocardial, renal, and body weight effects of doxorubicin in both strains of rats, these toxic effects are more severe in SHR than in WKY. SHR provide an useful animal model for the critical examination of agents with potential protective activity against doxorubicin-induced toxicity.
JF  - Toxicology and applied pharmacology
AU  - Herman, E H
AU  - el-Hage, A
AU  - Ferrans, V J
AD  - Division of Drug Biology, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 42
EP  - 53
VL  - 92
IS  - 1
SN  - 0041-008X, 0041-008X
KW  - Piperazines
KW  - 0
KW  - Razoxane
KW  - 5AR83PR647
KW  - Doxorubicin
KW  - 80168379AG
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Heart Rate -- drug effects
KW  - Drug Interactions
KW  - Rats, Inbred SHR
KW  - Body Weight -- drug effects
KW  - Blood Pressure -- drug effects
KW  - Species Specificity
KW  - Male
KW  - Kidney Diseases -- pathology
KW  - Razoxane -- pharmacology
KW  - Heart Diseases -- chemically induced
KW  - Kidney Diseases -- prevention & control
KW  - Doxorubicin -- toxicity
KW  - Heart Diseases -- prevention & control
KW  - Piperazines -- pharmacology
KW  - Heart Diseases -- pathology
KW  - Kidney Diseases -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-02
N1  - Date created - 1988-03-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane.
AN  - 78095995; 2828043
AB  - The spermicidal surfactant nonoxynol-9 (Igepal CO-630, GAF Corp.) and a potential impurity, 1,4-dioxane, were tested in the in vitro cell transformation assay using BALB/3T3 cells. Two treatment periods, 48 hr and 13 days, were used. Nonoxynol-9, tested at levels up to 10 micrograms/ml, did not induce transformation, whereas dioxane was very active in the induction of type III foci in the cultured BALB/3T3 cells.
JF  - Environmental and molecular mutagenesis
AU  - Sheu, C W
AU  - Moreland, F M
AU  - Lee, J K
AU  - Dunkel, V C
AD  - Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 41
EP  - 48
VL  - 11
IS  - 1
SN  - 0893-6692, 0893-6692
KW  - Detergents
KW  - 0
KW  - Dioxanes
KW  - Dioxins
KW  - Spermatocidal Agents
KW  - Surface-Active Agents
KW  - Nonoxynol
KW  - 26027-38-3
KW  - Polyethylene Glycols
KW  - 30IQX730WE
KW  - 1,4-dioxane
KW  - J8A3S10O7S
KW  - Index Medicus
KW  - Animals
KW  - Cell Survival -- drug effects
KW  - Mice
KW  - Cell Line
KW  - Detergents -- toxicity
KW  - Dioxanes -- toxicity
KW  - Spermatocidal Agents -- toxicity
KW  - Polyethylene Glycols -- toxicity
KW  - Surface-Active Agents -- toxicity
KW  - Cell Transformation, Neoplastic -- drug effects
KW  - Dioxins -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-26
N1  - Date created - 1988-02-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone.
AN  - 78083362; 3276507
AB  - A number of solvent compounds that were tested in Saccharomyces cerevisiae were potent inducers of aneuploidy, although they did not induce any other genetic effects. As an extention of these earlier findings, 1-methyl-2-pyrrolidinone was tested and was found to induce aneuploidy. Several structurally related compounds were also tested; 2-pyrrolidinone induced aneuploidy, but succinimide, pyrrolidine, 1-methylpyrrolidine, 1-methyl-3-pyrrolidinol, and 2-pyrrolidineethanol did not. Maleimide and its N-hydroxy, N-methyl, and N-ethyl derivatives were also negative for aneuploidy induction.
JF  - Environmental and molecular mutagenesis
AU  - Mayer, V W
AU  - Goin, C J
AU  - Taylor-Mayer, R E
AD  - Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 31
EP  - 40
VL  - 11
IS  - 1
SN  - 0893-6692, 0893-6692
KW  - Maleimides
KW  - 0
KW  - Pyrrolidinones
KW  - Solvents
KW  - Index Medicus
KW  - Maleimides -- toxicity
KW  - Structure-Activity Relationship
KW  - Saccharomyces cerevisiae -- genetics
KW  - Solvents -- toxicity
KW  - Aneuploidy
KW  - Saccharomyces cerevisiae -- drug effects
KW  - Pyrrolidinones -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-26
N1  - Date created - 1988-02-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Examination of minoxidil-induced acute cardiotoxicity in miniature swine.
AN  - 78075036; 3336882
AB  - Minoxidil, a vasodilating antihypertensive agent, was given orally in doses of 1, 3 or 10 mg/kg to miniature swine on 2 consecutive days. Mean arterial pressure decreased and heart rate increased most consistently after the 10 mg/kg dose. However, all 3 doses of minoxidil induced myocardial hemorrhages and/or left ventricular papillary muscle necrosis within 24 h after the second dose. Necrosis, characterized by hypercontraction of muscle cells and myofibrillar damage, occurred in 1 of 8 pigs given 1 mg/kg, 3 of 13 given 3 mg/kg and 7 of 14 given 10 mg/kg of minoxidil. The pharmacological effects of minoxidil, hypotension and reflex tachycardia, probably led to ischemia and necrosis in left ventricular papillary muscles. Gross hemorrhages involving the left atrium and to a lesser extent the left ventricle were found in 4 of 8 pigs given 1 mg/kg, 9 of 13 given 3 mg/kg and 11 of 14 given 10 mg/kg of minoxidil. The atrial lesions were manifested grossly by diffuse redness and microscopically by interstitial edema, extravasation of erythrocytes and infiltration of areas around small arteries and arterioles with acute and chronic inflammatory cells. The hemmorhagic areas were concentrated along the epicardial surfaces, and to a lesser extent along the endocardial surfaces. Atrial lesions induced by minoxidil preferentially involve the left atrium in pigs and the right atrium in dogs. These differences may be related to the anatomic patterns of coronary circulation in the 2 species.
JF  - Toxicology
AU  - Herman, E H
AU  - Ferrans, V J
AU  - Young, R S
AU  - Balazs, T
AD  - Division of Drug Biology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 41
EP  - 51
VL  - 48
IS  - 1
SN  - 0300-483X, 0300-483X
KW  - Minoxidil
KW  - 5965120SH1
KW  - Index Medicus
KW  - Swine
KW  - Administration, Oral
KW  - Animals
KW  - Heart Rate -- drug effects
KW  - Hemorrhage -- chemically induced
KW  - Dose-Response Relationship, Drug
KW  - Blood Pressure -- drug effects
KW  - Swine, Miniature
KW  - Male
KW  - Female
KW  - Minoxidil -- toxicity
KW  - Cardiomyopathies -- pathology
KW  - Heart -- drug effects
KW  - Cardiomyopathies -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-04
N1  - Date created - 1988-02-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - GEN
T1  - Notice, 11 July 1988.
AN  - 78037829; 12289360
AB  - On 11 July 1988, the US Food and Drug Administration approved the use of the cervical cap as a contraceptive.  The cap is to be used in conjunction with a spermicidal cream or jelly to prevent pregnancy. It must be left in place for a minimum of eight hours after intercourse and may be left in place for a maximum of 48 hours.
          full text
JF  - Annual review of population law
AU  - United States. Food and Drug Administration FDA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 19
VL  - 15
KW  - Spermatocidal Agents
KW  - 0
KW  - Population
KW  - United States
KW  - North America
KW  - Americas
KW  - Barrier Methods
KW  - Contraceptive Methods
KW  - Developed Countries
KW  - Knowledge
KW  - Cervical Cap
KW  - Northern America
KW  - Vaginal Spermicides
KW  - Contraception
KW  - Vaginal Barrier Methods
KW  - Product Approval
KW  - Family Planning
KW  - Legislation
KW  - Family Planning Services
KW  - Consumer Product Safety
KW  - Contraceptive Devices, Female
KW  - Legislation as Topic
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1995-09-07
N1  - Date created - 1995-09-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Tamoxifen inhibits estrogen-induced hepatic injury in hamsters.
AN  - 78024597; 3335202
AB  - Estrogens have an unusual toxic effect on the liver of two hamster species, the Armenian and the Chinese hamster. The hepatotoxicity was detectable clinically by hyperbilirubinemia and confirmed histologically by the presence of hepatic degenerative-regenerative changes. Administration of tamoxifen with estrogen [either ethynyl estradiol or diethylstilbestrol (DES)] completely abrogated the hepatotoxic effects, suggesting that estrogen receptor (ER) was necessary for estrogen to damage liver. In Armenian hamsters, estrogens decreased hepatic synthesis of female protein (FP); tamoxifen also abolished this DES effect and resulted in a net increase in serum FP levels. DES administration produced higher serum bilirubin levels and lower serum FP levels in females than in males. Paradoxically, tamoxifen blocked these DES effects more effectively and efficiently in females than in males. Estrogens did not injure uteri of Armenian and Chinese hamsters and were nontoxic to livers of other hamsters species, such as Syrian and Turkish. This model provides another perspective of the acute cellular derangement that can be effected by estrogen-ER complex and may indicate a yet unknown mode of ER action.
JF  - Endocrinology
AU  - Coe, J E
AU  - Ross, M J
AD  - Department of Health and Human Services, National Institutes of Health, Hamilton, Montana 59840.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 137
EP  - 144
VL  - 122
IS  - 1
SN  - 0013-7227, 0013-7227
KW  - Tamoxifen
KW  - 094ZI81Y45
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Animals
KW  - Sex Factors
KW  - Cricetulus
KW  - Time Factors
KW  - Species Specificity
KW  - Male
KW  - Female
KW  - Cricetinae
KW  - Tamoxifen -- pharmacology
KW  - Liver -- pathology
KW  - Liver -- drug effects
KW  - Diethylstilbestrol -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-03
N1  - Date created - 1988-02-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Applicability of Cancer Risk Assessment Techniques To Other Toxic Effects
AN  - 760215073; 13641437
AB  - The purpose of this paper is to investigate the applicability of cancer risk assessment techniques to other endpoints. The discussion is limited to the problem of high to low dose extrapolation. Although developed to describe cancer data, the multistage model has a general sigmoidal shape which makes it amenable to describe the dose-response of many non-cancer endpoints. At low doses the multistage model is essentially a general polynomial model. Low-dose linear extrapolation provides an upper limit on convex (curving upward) dose-response curves. Low-dose linearity is expected if exposure to a toxic substance augments a disease process which is already operating in unexposed animals. Incorporation of pharma. cokinetic information may prove useful in simplifying dose-response relationships and may result in lower estimates of risk. A descriptive model can be used to estimate a lower confidence limit on a dose expected to produce a disease incidence, for example, of 1% of the animals (LED sub(01)). Then, the LED sub(01)/100 provides an estimate of the dose for which the risk is estimated to be less than 10 super(-4). It appears that some of the techniques used for cancer risk assessment can be used or modified for quantal non-cancer endpoints.
JF  - Toxicology and Industrial Health
AU  - Gaylor, David W
AD  - National Center for Toxicological Research Jefferson, Arkansas
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 453
EP  - 459
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 4
IS  - 4
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - dose-response relationship
KW  - extrapolation
KW  - multistage model
KW  - risk assessment.
KW  - Risk assessment
KW  - Data processing
KW  - Dose-response effects
KW  - Risk factors
KW  - Cancer
KW  - Models
KW  - X 24350:Industrial Chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 12
N1  - Last updated - 2015-04-02
N1  - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Risk factors; Dose-response effects; Cancer; Models
DO  - http://dx.doi.org/10.1177/074823378800400404
ER  - 



TY  - GEN
T1  - Laboratory Animal Welfare Supplement IV.
AN  - 63105501; ED307167
AB  - This document is the fourth supplement to a 1984 bibliography on laboratory animal welfare. Items presented were selected because they represent some of the most significant of those providing recent information or because they were considered useful. The period covered is October, 1986 through October, 1987. Monographs, conference proceedings, and numerous journal articles are organized into eight groups: (1) "Historical Aspects"; (2) "Ethical and Philosophical Aspects"; (3) "Animal Rights"; (4) "Laws, Regulations, Codes, and Guidelines"; (5) "Animal Research Committees"; (6) "Animal Experimentation in Specific Disciplines"; (7) "Replacement, Reduction, Refinement"; and (8) "Other Aspects." (CW)
AU  - Gluckstein, Fritz P.
Y1  - 1988/01//
PY  - 1988
DA  - January 1988
SP  - 18
PB  - Editor, Specialized Bibliography Series, Reference Section, National Library of Medicine, Bethesda, MD 20894 (send self-addressed gummed label).
KW  - Animal Welfare
KW  - ERIC, Resources in Education (RIE)
KW  - Animals
KW  - Zoology
KW  - Laboratories
KW  - Ethics
KW  - Research
KW  - Laboratory Animals
KW  - Animal Facilities
KW  - Laboratory Procedures
KW  - Animals
KW  - Zoology
KW  - Laboratories
KW  - Ethics
KW  - Research
KW  - Laboratory Animals
KW  - Animal Facilities
KW  - Laboratory Procedures
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LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - The United States Public Health Policy: Managed by Objectives
AN  - 61592568; 199001545
AB  - An overview of national policy on disease prevention & health promotion in the US since 1980. Specific health targets for reducing death & disability & promoting health were specified in an initiative based on the principle of management by objectives (MBO). As a decision-making tool, MBO guides the planning, implementation, & evaluation of US policy. The public health campaign is comprehensive, targeting improvements with respect to health, risk factor profiles, services research, monitoring, & public/professional understanding. The knowledge-based aspects of professional understanding of the campaign are described in detail; barriers to progress are reviewed. Real progress for the national agenda must come through adoption of the principles, objectives, targets, & foci of the health promotion & disease prevention campaign, by both individual caregivers & the recipients of health care services. 6 Tables, 4 Figures. Modified HA
JF  - Innovation
AU  - McGinnis, J Michael
AU  - Harrell, James A
AD  - US Public Health Service, 5600 Fishers Lane Rockville MD 20852
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 167
EP  - 185
VL  - 1
IS  - 2 -- 3
SN  - 1351-1610, 1351-1610
KW  - public health policy objectives/strategies, US, 1980-present
KW  - *Health Policy
KW  - *United States of America
KW  - *Public Health
KW  - article
KW  - 6124: social welfare
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LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2007-05-01
N1  - Last updated - 2012-02-15
N1  - SubjectsTermNotLitGenreText - *United States of America; *Public Health; *Health Policy
ER  - 



TY  - BOOK
T1  - The surgeon general's report on nutrition and health
T2  - Dept. of Health and Human Services. DHHS pubn. no. (PHS) 88-50210
AN  - 59509747; 1990-0100140
AB  - First issue. Examines the relationship of diet to chronic disease.
JF  - Supt Docs, 1988. xxxvii+727 pp.
Y1  - 1988///0,
PY  - 1988
DA  - 0, 1988
EP  - xxxvii+727
PB  - Supt Docs
KW  - Diet -- United States
KW  - Medicine, Preventive -- United States
KW  - Health -- United States
KW  - Nutrition -- United States
KW  - Chronically ill -- United States
KW  - United States -- Surgeon general
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Supt Docs pa $22
N1  - Document feature - bibl(s), table(s), diag(s), chart(s), index(es)
N1  - Last updated - 2016-09-28
ER  - 



TY  - BOOK
T1  - Nursing shortage: strategies for nursing practice and education; report of the National Invitational Workshop, February 22-24, 1988
AN  - 59505909; 1989-1201774
AB  - Proceedings of the conference organized by the Division of Nursing, held in Washington, D.C. Includes overview of nurse manpower and related issues, recruitment, and retention strategies.
JF  - Nat Tech Info Service, 1988. vi+161 pp.
Y1  - 1988///0,
PY  - 1988
DA  - 0, 1988
EP  - vi+161
PB  - Nat Tech Info Service
KW  - United States -- Medical sector
KW  - Nursing education -- United States
KW  - Nursing -- Supply and demand
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Nat Tech Info Service pa
N1  - Document feature - bibl(s), table(s), chart(s)
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Loading characteristics of pillars in multiple-seam mining operations
AN  - 51277061; 2008-042052
JF  - Report of Investigations - United States. Bureau of Mines
AU  - Chekan, G J
AU  - Matetic, R J
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 19
PB  - U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Washington, D.C.
SN  - 1066-5552, 1066-5552
KW  - multiple seam mining
KW  - mining
KW  - mines
KW  - measurements
KW  - stress
KW  - coal mines
KW  - coal mining
KW  - pillars
KW  - 30:Engineering geology
KW  - 26A:Economic geology, general, deposits
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LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from the AESIS Database supplied under licence from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia
N1  - Date revised - 2008-01-01
N1  - Number of references - 14
N1  - PubXState - D.C.
N1  - Document feature - illus. incl. 6 tables
N1  - SuppNotes - Includes appendix
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - coal mines; coal mining; measurements; mines; mining; multiple seam mining; pillars; stress
ER  - 



TY  - BOOK
T1  - Research symposium on child sexual abuse, May 17-19, 1988
AN  - 42405591; 15060
AB  - In May 1988, the National Center on Child Abuse and Neglect convened a Research Symposium on Child Sexual abuse to highlight research findings, issues, and future directions. This document includes the proceedings from the Symposium, an overview of the NCCAN-funded and related activities, and an annotated bibliography. [Text, p. ii]
JF  - Washington: U.S. Department of Health and Human Services, Children's Bureau, 1988. 1 pp.
AU  - National Center on Child Abuse and Neglect
PY  - 1988
SP  - 1
PB  - U.S. Department of Health and Human Services, Children's Bureau
KW  - Bibliography
KW  - Child Abuse
KW  - Effects
KW  - Incest
KW  - Rape
KW  - Research Needs
KW  - Survivors
KW  - Treatment
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LA  - English
DB  - PILOTS: Published International Literature On Traumatic Stress
N1  - Date revised - 2016-09-15
N1  - Last updated - 2016-09-15
ER  - 



TY  - BOOK
T1  - Health insurance and the demand for medical care - evidence from a randomized experiment
T2  - Health insurance experiment series
AN  - 37335514; 1120360
JF  - Health insurance and the demand for medical care - evidence from a randomized experiment
AU  - Manning, Willard G
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 99
EP  - xviii, 99
PB  - Rand
SN  - 0833008641
KW  - Medical care
KW  - Health insurance
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/International+Bibliography+of+the+Social+Sciences+%28IBSS%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Manning%2C+Willard+G&rft.aulast=Manning&rft.aufirst=Willard&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=xviii&rft.isbn=0833008641&rft.btitle=Health+insurance+and+the+demand+for+medical+care+-+evidence+from+a+randomized+experiment&rft.title=Health+insurance+and+the+demand+for+medical+care+-+evidence+from+a+randomized+experiment&rft.issn=&rft_id=info:doi/
LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - SuppNotes - Bibliography, p. 89-99
N1  - Last updated - 2013-09-16
ER  - 



TY  - JOUR
T1  - Parts-Per-Trillion Levels of Polychlorinated Dibenzofurans Found in the Edible Portion of Selected Fish
AN  - 19067247; 8903649
AB  - Fillets of thirty-five fish were examined for polychlorinated dibenzofurans. The fish were from 8 sites contaminated with industrial chemicals or with known or suspected levels of polychlorinated biphenyls. Polychlorinated dibenzofurans were extracted and cleaned up by column chromatography on a series of modified silica gels, carbon and aluminum adsorbents. Selected ion mass spectrometry with capillary gas chromatography was used for quantification. Predominant polychlorinated dibenzofurans found were: (1) 2,3,7,8-tetra-chlorinated dibenzofuran which occurred in 13 fish at levels up to 95 ppt, and (2) 2,3,4,7 ,8-penta-chlorinated dibenzofuran which occurred in 14 fish at levels up to 114 ppt. Other tri- through hepta-chlorinated dibenzofurans were found with less frequency. These were tentatively identified as 2,4,6-substituted polychlorinated dibenzofurans. Polychlorinated dibenzofurans were not found in 15 fish. Whereas the presence of polycyclic aromatic hydrocarbons in seven fish had been judged an indicator of polychlorinated dibenzofuran contamination in fish, the absence of polychlorinated dibenzofurans in seven fish with up to 45 ppm polycyclic aromatic hydrocarbon suggested that this correlation may not always be valid. (See also W89-03595) (Author 's abstract)
JF  - Preprints of Papers Presented at the 196th ACS National Meeting. Vol. 28 No. 2. Division of Environmental Chemistry, American Chemical Society, Washington, DC. 1988. p 388-390. 1 tab, 9 ref.
AU  - Gardner, A M
AU  - White, K D
AD  - Food and Drug Administration Washington, DC. Contaminants Chemistry Div
Y1  - 1988
PY  - 1988
DA  - 1988
KW  - Water Resources Abstracts
KW  - Toxic wastes
KW  - Path of pollutants
KW  - Polychlorinated
KW  - Fish
KW  - Gas chromatography
KW  - Mass spectrometry
KW  - Dibenzofurans
KW  - Water pollution effects
KW  - Chlorinated hydrocarbons
KW  - Pollutant identification
KW  - SW 3020:Sources and fate of pollution
KW  - SW 3030:Effects of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Gas Chromatographic/Mass Spectrometric Confirmation of Identity of Coprostanol in Mercenaria mercenaria (Bivalvia) Taken from Sewage-Polluted Water
AN  - 19059588; 8903471
AB  - Coprostanol is a major fecal sterol in humans and may, therefore , be a good indicator of sewage-polluted waters. Some types of edible seafood, such as clams, that live in these waters may be contaminated with coprostanol. Coprostanol from clam tissue extracts had been previously quantitated by gas chromatography (GC). In the present work, capillary column GC was used to separate coprostanol, and electron ionization mass spectrometry was used to confirm its identity. Confirmation of identity of coprostanol at the 75 ng level was obtained by comparing the spectrum of the authentic standard with spectra of the clam tissue extract obtained under the same instrumental conditions. Various other compounds can be eliminated as potential interferences by virtue of either their different GC retention times or their spectra. (Author 's abstract)
JF  - Journal - Association of Official Analytical Chemists JANCA2 Vol. 71, No. 5, p 994-999, September-October 1988. 6 fig, 2 tab, 14 ref.
AU  - Matusik, JE
AU  - Hoskin, G P
AU  - Sphon, JA
AD  - Food and Drug Administration Washington, DC. Center for Food Safety and Applied Nutrition
Y1  - 1988/01//
PY  - 1988
DA  - Jan 1988
KW  - Water Resources Abstracts
KW  - Clams
KW  - Indicators
KW  - Coprosterol
KW  - Pollutant identification
KW  - Organic compounds
KW  - Gas chromatography
KW  - Separation techniques
KW  - Mass spectrometry
KW  - SW 3010:Identification of pollutants
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Identification of Escherichia Coli from Shellfish and Related Environments by Automicrobic System
AN  - 19026464; 8810461
AB  - A total of 463 fecal coliform positive isolates obtained from shellfish and related samples gave typical Escherichia coli IMViC reactions. E. Coli identifications for 458 (99%) of these isolates were confirmed using a combination of the Automicrobic System (AMS) and the API 20E system (reference system). The AMS (test system) identified 433 isolates as E. coli; the remaining 25 (5%) isolates were identified as E. hermanii by the test system and as E. coli by the reference system. Additional tests performed on the isolates identified as E. hermanii confirmed those AMS identifications to be incorrect. (Author 's abstract)
JF  - Journal - Association of Official Analytical Chemists JANCA2 Vol. 71, No. 3, p 582-584, May/June 1988. 2 tab, 10 ref.
AU  - Tardio, J L
AU  - O'Brien, K
AU  - Latt, T
AD  - Food and Drug Administration Baltimore, MD. Baltimore District Office
Y1  - 1988/01//
PY  - 1988
DA  - Jan 1988
KW  - Water Resources Abstracts
KW  - Pollutant identification
KW  - Shellfish
KW  - Automation
KW  - Bacterial analysis
KW  - Escherichia coli
KW  - Bacteria
KW  - Chemical analyis
KW  - Population exposure
KW  - Autoanalyzers
KW  - SW 3010:Identification of pollutants
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Coping with Sampling Variability in Biota; Percentiles and Other Strategies
AN  - 19017805; 8809428
AB  - Problems in obtaining representative samples of biota are related to the large variability encountered and the corresponding uncertainties in the estimates. Also, the distribution of values (for example, mercury concentrations in fish) may not be normal, that is bell-shaped, or of Gaussian distribution. To reduce the uncertainties, several strategies may be applied: increasing the number of units sampled or breaking down the population into distinct subgroups. The distribution of the individual values should be indicated. For biota, the various percentile points can be reported along with the confidence limits derived from the binomial distribution. The final results of sampling biota may well be an average plus key percentiles of the distribution values. (See also W88-09415) (Cassar-PTT)
JF  - Principles of Environmental Sampling. American Chemical Society. 1988. p 337-353 3 tab, 4 ref, append.
AU  - Albert, R
AU  - Horwitz, W
AD  - Food and Drug Administration Washington, DC. Center for Food Safety and Applied Nutrition
Y1  - 1988
PY  - 1988
DA  - 1988
KW  - Water Resources Abstracts
KW  - Pollutant identification
KW  - Sampling
KW  - Bioaccumulation
KW  - Fish
KW  - Biological samples
KW  - Aquatic life
KW  - Statistical analysis
KW  - Gaussian distribution
KW  - Variability
KW  - SW 5040:Data acquisition
KW  - SW 3010:Identification of pollutants
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Coping+with+Sampling+Variability+in+Biota%3B+Percentiles+and+Other+Strategies&rft.au=Albert%2C+R%3BHorwitz%2C+W&rft.aulast=Albert&rft.aufirst=R&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Regulatory significance of Aeromonas in foods.
AN  - 15746495; 2357561
AB  - Aeromonas hydrophila and other Aeromonas spp. are commonly found in fresh water and in foods. Although their isolation from stools of persons with diarrhea has implicated them as a cause of diarrheal disease, these microbes have failed to produce disease, even at very high doses, in voluntary human feeding studies. The presence of A. hydrophila in foods destined for cancer patients is certainly contraindicated, but at present Aeromonas spp. should be considered putative causes of acute gastroenteritis in normal persons. However, regulatory action based on health concerns seems insupportable at this time.
JF  - Journal of Food Safety
AU  - Archer, D L
AU  - Kvenberg, JE
AD  - Div. Microbiol., Cent. Food Saf. and Appl. Nutr., FDA, 200 C. St. SW, Washington, DC 20204, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 53
EP  - 58
VL  - 9
IS  - 1
SN  - 0149-6085, 0149-6085
KW  - Aeromonas hydrophila
KW  - foods
KW  - gastrointestinal diseases
KW  - Health & Safety Science Abstracts
KW  - H SE4.27:FOOD PROCESSING INDUSTRIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15746495?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Safety&rft.atitle=Regulatory+significance+of+Aeromonas+in+foods.&rft.au=Archer%2C+D+L%3BKvenberg%2C+JE&rft.aulast=Archer&rft.aufirst=D&rft.date=1988-01-01&rft.volume=9&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Safety&rft.issn=01496085&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - Potential sources of Aeromonas hydrophila .
AN  - 15743846; 2357791
AB  - Aeromonas species are associated with marine and fresh water environments, including natural mineral springs, chlorinated and unchlorinated domestic supplies, and polluted water sheds. Most studies attribute water supplied as the principal source for A. hydrophila . Recently, Aeromonas has been recognized as a potential cause of food-associated gastroenteritis outbreaks. Its actual involvement in large foodborne outbreaks is presently unknown. Aeromonas can be readily isolated from a variety of food sources such as seafoods, meats, dairy products, and poultry. Another potential source is asymptomatic and immuno-compromised individuals, particularly, food-handling workers.
JF  - Journal of Food Safety
AU  - Abeyta, C Jr
AU  - Wekell, M M
AD  - Seafood Prod. Res. Cent., FDA., 5009 Federal Off. Build., 909 First Ave., Seattle, WA 98174, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 11
EP  - 22
VL  - 9
IS  - 1
KW  - Aeromonas hydrophila
KW  - marine environments
KW  - gastrointestinal diseases
KW  - foods
KW  - Health & Safety Science Abstracts
KW  - water supplies
KW  - freshwater environments
KW  - H SE4.27:FOOD PROCESSING INDUSTRIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15743846?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Safety&rft.atitle=Potential+sources+of+Aeromonas+hydrophila+.&rft.au=Abeyta%2C+C+Jr%3BWekell%2C+M+M&rft.aulast=Abeyta&rft.aufirst=C&rft.date=1988-01-01&rft.volume=9&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Safety&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - freshwater environments; water supplies
ER  - 



TY  - JOUR
T1  - FDA Arthritis Advisory Committee meeting: Serious gastrointestinal toxicity of nonsteroidal antiinflammatory drugs; drug-containing renal and biliary stones; diclofenac and carprofen approved.
AN  - 15636659; 2276092
AB  - NSAID-class information is inserted into the labels of all NSAIDs, and the labels are continually revised as additional information becomes available. Because of increased concern that the risks of serious gastrointestinal (GI) toxicity do not decrease with the duration of therapy, the FDA Arthritis Advisory Committee, at its twenty-second meeting in May 1988, decided that the GI paragraphs should be modified. The revised paragraphs are discussed.
JF  - Arthritis & Rheumatism
AU  - Paulus, HE
AD  - ARA Liaison FDA Arthritis Adv. Comm., UCLA Sch. Med., Dep. Med., Div. Rheumatol., 1000 Veteran Ave., 32-47, Los Angeles, CA 90024-1670, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 1450
EP  - 1451
VL  - 31
IS  - 11
SN  - 0004-3591, 0004-3591
KW  - antiinflammatory agents
KW  - regulation
KW  - toxicity
KW  - Toxicology Abstracts
KW  - gastrointestinal tract
KW  - man
KW  - X 24113:Side effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15636659?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+%26+Rheumatism&rft.atitle=FDA+Arthritis+Advisory+Committee+meeting%3A+Serious+gastrointestinal+toxicity+of+nonsteroidal+antiinflammatory+drugs%3B+drug-containing+renal+and+biliary+stones%3B+diclofenac+and+carprofen+approved.&rft.au=Paulus%2C+HE&rft.aulast=Paulus&rft.aufirst=HE&rft.date=1988-01-01&rft.volume=31&rft.issue=11&rft.spage=1450&rft.isbn=&rft.btitle=&rft.title=Arthritis+%26+Rheumatism&rft.issn=00043591&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - gastrointestinal tract; man
ER  - 



TY  - BOOK
T1  - Media evaluation and behavior of Clostridium perfringens as an adjunct indicator of quality in shellfish growing areas.
AN  - 15480865; 2214594
AB  - In numerous studies of estuaries of the West coast of the United States, we have recovered C. perfringens , total and fecal coliforms, and fecal streptococci from shellfish, sediments and water. In some areas closed to shellfish harvest and known to be subject to fecal contamination, C. perfringens were recovered regularly from shellfish and sediments.
JF  - Water Science & Technology. 1988.
AU  - Abeyta, C Jr
AU  - Wekell, M M
AU  - Kaysner, CA
AU  - Stott, R F
AU  - Raghubeer, E V
AU  - Matches, J R
AU  - Peeler, J T
A2  - Parker, WR (ed)
Y1  - 1988
PY  - 1988
DA  - 1988
SN  - 0080368859
KW  - Clostridium perfringens
KW  - shellfish
KW  - Pollution Abstracts
KW  - Marine
KW  - water quality
KW  - Brackish
KW  - environmental monitoring
KW  - fermentation
KW  - bioindicators
KW  - P 1000:MARINE POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15480865?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Abeyta%2C+C+Jr%3BWekell%2C+M+M%3BKaysner%2C+CA%3BStott%2C+R+F%3BRaghubeer%2C+E+V%3BMatches%2C+J+R%3BPeeler%2C+J+T&rft.aulast=Abeyta&rft.aufirst=C&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0080368859&rft.btitle=Media+evaluation+and+behavior+of+Clostridium+perfringens+as+an+adjunct+indicator+of+quality+in+shellfish+growing+areas.&rft.title=Media+evaluation+and+behavior+of+Clostridium+perfringens+as+an+adjunct+indicator+of+quality+in+shellfish+growing+areas.&rft.issn=02731223&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - Fetal occupational injuries in the United States in 1980-1984. Results of the first national census of traumatic occupational fatalities.
AN  - 15410375; 2146633
AB  - This paper describes characteristics of these fatal occupational injuries from a national perspective for the five year period 1980 through 1984.
JF  - Scandinavian Journal of Work, Environment & Health [SCAND. J. WORK ENVIRON. HEALTH.]. Vol. 14, no. 1 Suppl. 1988.
AU  - Stout-Wiegand, N
A2  - Lindstroem, K (ed)
Y1  - 1988
PY  - 1988
DA  - 1988
EP  - no. 1 Sul.
KW  - United States
KW  - trauma
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - mortality
KW  - occupational health
KW  - H SI0.4:ACCIDENT INVESTIGATION
KW  - H SM9.1:BASIC APPROACHES, CONCEPTS, AND THEORY
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15410375?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stout-Wiegand%2C+N&rft.aulast=Stout-Wiegand&rft.aufirst=N&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=no.+1+Sul.&rft.isbn=&rft.btitle=Fetal+occupational+injuries+in+the+United+States+in+1980-1984.+Results+of+the+first+national+census+of+traumatic+occupational+fatalities.&rft.title=Fetal+occupational+injuries+in+the+United+States+in+1980-1984.+Results+of+the+first+national+census+of+traumatic+occupational+fatalities.&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - Atlas of standardized low-back tests and measures of the National Institute for Occupational Safety and Health.
AN  - 15410044; 2146603
JF  - Scandinavian Journal of Work, Environment & Health [SCAND. J. WORK ENVIRON. HEALTH.]. Vol. 14, no. 1 Suppl. 1988.
AU  - Nelson, R M
AU  - Nestor, DE
A2  - Lindstroem, K (ed)
Y1  - 1988
PY  - 1988
DA  - 1988
EP  - no. 1 Sul.
KW  - occupational health
KW  - back injuries
KW  - monitoring measurements
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - H SM9.46:BACK INJURIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15410044?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Nelson%2C+R+M%3BNestor%2C+DE&rft.aulast=Nelson&rft.aufirst=R&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=no.+1+Sul.&rft.isbn=&rft.btitle=Atlas+of+standardized+low-back+tests+and+measures+of+the+National+Institute+for+Occupational+Safety+and+Health.&rft.title=Atlas+of+standardized+low-back+tests+and+measures+of+the+National+Institute+for+Occupational+Safety+and+Health.&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - Exposure to job stress -- a new psychometric instrument.
AN  - 15400042; 2145905
AB  - Concerns of occupational health specialists are shifting to psychosocial threats as physical and chemical risks are reduced as a result of improved industrial hygiene practices and the rapid growth of service occupations and industries. The dominant methodology for examining psychosocial stress at work has been a questionnaire survey approach involving workers' self-reports of job characteristics and health-related complaints--the former achieving "stressor" status if correlated with the latter. While this approach has generated important findings, it has also proved problematic.
JF  - Scandinavian Journal of Work, Environment & Health. 1988.
AU  - Hurrell, JJ Jr
AU  - McLaney, MA
A2  - Lindstroem, K (ed)
Y1  - 1988
PY  - 1988
DA  - 1988
KW  - occupational health
KW  - risk assessment
KW  - Health & Safety Science Abstracts
KW  - psychology
KW  - stress
KW  - surveys
KW  - human factors
KW  - H SI0.7:HUMAN FACTORS
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15400042?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hurrell%2C+JJ+Jr%3BMcLaney%2C+MA&rft.aulast=Hurrell&rft.aufirst=JJ&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Exposure+to+job+stress+--+a+new+psychometric+instrument.&rft.title=Exposure+to+job+stress+--+a+new+psychometric+instrument.&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - Comparison between two power-frequency electric-field dosimeters.
AN  - 15394623; 2146085
AB  - The measured values need to be adjusted to compensate for field perturbation enhancement, because exposure assessments should not be affected by the location of the instrumentation sensor. After the adjustments are made, results can be compared with measurements of the unperturbed field. When a conducting object is placed in an electric field, currents are induced in the object. The sum of all currents flowing in different paths in the object could be measured as the current which is flowing to the ground, if the object is connected there. This current is called the short circuit current.
JF  - Scandinavian Journal of Work, Environment & Health [SCAND. J. WORK ENVIRON. HEALTH.]. Vol. 14, no. 1 Suppl. 1988.
AU  - Lindh, T
AU  - Andersson, L-I
A2  - Lindstroem, K (ed)
Y1  - 1988
PY  - 1988
DA  - 1988
EP  - no. 1 Sul.
KW  - electric fields
KW  - monitoring measurements
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - occupational health
KW  - P 8000:RADIATION
KW  - H SI0.9.1:RADIATION HAZARDS
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15394623?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lindh%2C+T%3BAndersson%2C+L-I&rft.aulast=Lindh&rft.aufirst=T&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=no.+1+Sul.&rft.isbn=&rft.btitle=Comparison+between+two+power-frequency+electric-field+dosimeters.&rft.title=Comparison+between+two+power-frequency+electric-field+dosimeters.&rft.issn=03553140&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - A multistage approach to the cohort analysis of lifetime lung cancer risk among steelworkers exposed to coke oven emissions.
AN  - 15390798; 2142353
AB  - A cohort analysis was performed to predict the lifetime lung cancer risk to a US or Canadian nonwhite male steelworker exposed to coke oven emissions. The procedure employed required that the lung cancer mortality (used for risk assessment) be estimated by addition of the excess to the background rates. The age-specific excess rates were obtained following selection of the proper excess risk function as implied by the multistage theory of carcinogenesis. A quantitative approach based on model fitting was used for selection of the excess risk function. The results show no evidence that coke oven emissions have a late stage carcinogenic effect. The indication that the agent acts as an initiator is moderate to weak.
JF  - American Journal of Epidemiology
AU  - Dong, M H
AU  - Redmond, C K
AU  - Mazumdar, S
AU  - Costantino, J P
AD  - Cent. Drug Eval. and Res., FDA HFD-710, Rm. 18B45, 5600 Fishers Lane, Rockville, MD 20857, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 860
EP  - 873
VL  - 128
IS  - 4
SN  - 0002-9262, 0002-9262
KW  - cancer
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - emissions
KW  - occupational health
KW  - carcinogens
KW  - coke
KW  - risk assessment
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - H SI2.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15390798?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=A+multistage+approach+to+the+cohort+analysis+of+lifetime+lung+cancer+risk+among+steelworkers+exposed+to+coke+oven+emissions.&rft.au=Dong%2C+M+H%3BRedmond%2C+C+K%3BMazumdar%2C+S%3BCostantino%2C+J+P&rft.aulast=Dong&rft.aufirst=M&rft.date=1988-01-01&rft.volume=128&rft.issue=4&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - risk assessment; coke; occupational health; emissions; carcinogens
ER  - 



TY  - JOUR
T1  - An epidemiologic study of sudden death at work in an industrial county, 1979-1982.
AN  - 15344249; 2101174
AB  - The descriptive epidemiology of sudden death at work was studied in an urban, industrial county. County coroner's records were used to identify the 212 deaths that occurred at work among employed white males in Allegheny County, Pennsylvania in 1979-1982. Occupations and industries with increased risks for either sudden natural deaths or fatal injuries at work were identified by comparison with the white male county employed population. Men employed in service occupations had the highest age-adjusted sudden natural death rate at work (27.0 per 100,000). This was 2.5 times as high as the overall county rate. Men employed in the construction industry had the highest age-adjusted rate of fatal injuries at work (24.3 per 100,000). This was 4.4 times as high as the overall county rate.
JF  - American Journal of Epidemiology
AU  - Robinson, C C
AU  - Kuller, L H
AU  - Perper, J
AD  - NIOSH, Mailstop R-18, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 806
EP  - 820
VL  - 128
IS  - 4
SN  - 0002-9262, 0002-9262
KW  - cardiovascular diseases
KW  - Pennsylvania, Allegheny County
KW  - Health & Safety Science Abstracts
KW  - accidents
KW  - mortality
KW  - epidemiology
KW  - occupational health
KW  - H SI0.4:ACCIDENT INVESTIGATION
KW  - H SM10.22:CARDIOVASCULAR SYSTEM DISEASES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15344249?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=An+epidemiologic+study+of+sudden+death+at+work+in+an+industrial+county%2C+1979-1982.&rft.au=Robinson%2C+C+C%3BKuller%2C+L+H%3BPerper%2C+J&rft.aulast=Robinson&rft.aufirst=C&rft.date=1988-01-01&rft.volume=128&rft.issue=4&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mortality; accidents; epidemiology; occupational health
ER  - 



TY  - JOUR
T1  - Good laboratory practice regulations of the Food and Drug Administration.
AN  - 15306399; 2059289
AB  - This part prescribes good laboratory practices for conducting nonclinical laboratory studies that support or are intended to support applications for research or marketing permits for products regulated by the Food and Drug Administration, including food and color additives, animal additives, human and animal drugs, medical devices for human use, biological products, and electronic products. Compliance with this part is intended to assure the quality and integrity of the safety data filed pursuant to sections 406, 408, 409, 502, 503, 505, 506, 507, 510, 512-516, 518-520, 706, and 801 of the Federal Food, Drug, and Cosmetic Act and sections 351 and 354-360F of the Public Health Service Act.
JF  - J. TOXICOL.: CUTAN. OCULAR TOXICOL.
AU  - Anonymous
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 17
EP  - 34
VL  - 7
IS  - 1-2
KW  - regulations
KW  - laboratories
KW  - Toxicology Abstracts
KW  - toxicity testing
KW  - X 24230:Legislation & recommended standards
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15306399?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+TOXICOL.%3A+CUTAN.+OCULAR+TOXICOL.&rft.atitle=Good+laboratory+practice+regulations+of+the+Food+and+Drug+Administration.&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=1988-01-01&rft.volume=7&rft.issue=1-2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=J.+TOXICOL.%3A+CUTAN.+OCULAR+TOXICOL.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Special issue: International Directory of Contract Laboratories.
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - toxicity testing
ER  - 



TY  - JOUR
T1  - Good clinical practice regulations of the Food and Drug Administration.
AN  - 15303870; 2059308
JF  - J. TOXICOL.: CUTAN. OCULAR TOXICOL.
AU  - Anonymous
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 35
EP  - 52
VL  - 7
IS  - 1-2
KW  - regulations
KW  - clinical aspects
KW  - toxicity testing
KW  - Toxicology Abstracts
KW  - man
KW  - X 24230:Legislation & recommended standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Special issue: International Directory of Contract Laboratories.
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - man
ER  - 



TY  - JOUR
T1  - Occupational skin diseases, United States.
AN  - 15293710; 2043741
AB  - The overall incidence rates, numbers, and proportions of occupational skin diseases recorded in the Bureau of Labor Statistics Annual Survey of Occupational Injuries and Illnesses, from 1973 through 1984, were reviewed, and a detailed analysis of occupational skin disease recorded in the 1984 Annual Survey was performed. Overall incidence rates and numbers of cases declined from 1973 through 1983, but increased slightly in 1984. The major industrial divisions of agriculture and manufacturing have consistently had the highest rates and numbers of cases, respectively; skin diseases have accounted for almost two thirds of all occupational illnesses within agriculture. In the 1984 Annual Survey, 11 industries were ranked in the "Top 15" for both incidence rates and numbers of cases, at the two-digit Standard Industrial Classification levels. At the four-digit level for manufacturing, four industries were also ranked in the "Top 15" for both indexes. This analysis has identified industries toward which research efforts should be directed to characterize those occupational activities or exposures most responsible for these higher risks.
JF  - Archives of Dermatology
AU  - Mathias, CGT
AU  - Morrison, J H
AD  - NIOSH, R-13, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 1519
EP  - 1524
VL  - 124
IS  - 10
SN  - 0003-987X, 0003-987X
KW  - United States
KW  - Health & Safety Science Abstracts
KW  - surveys
KW  - diseases
KW  - occupational health
KW  - skin
KW  - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - H SM10.38:SKIN DISEASES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - skin; diseases; occupational health; surveys
ER  - 



TY  - JOUR
T1  - Principles of drug absorption and recent studies of bioavailability in aquatic species.
AN  - 15237186; 1997721
AB  - An overview is presented on the absorption of drugs and other xenobiotics in mammals and fish. Species differences in gastrointestinal tract physiology as well as other factors that influence bioavailability of these compounds are considered. Results of recent studies on the bioavailability of drugs in aquatic animal species are discussed.
JF  - Veterinary and Human Toxicology
AU  - Guarino, A M
AU  - Plakas, S M
AU  - Dickey, R W
AU  - Zeeman, M
AD  - Fish. Res. Branch, FDA, P.O. Box 158, Dauphin Island, AL 36528, USA
Y1  - 1988
PY  - 1988
DA  - 1988
VL  - 30
SN  - 0145-6296, 0145-6296
KW  - absorption
KW  - animal physiology
KW  - animals
KW  - aquatic animals
KW  - bioavailability
KW  - drugs
KW  - fish
KW  - gastrointestinal tract
KW  - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; ASFA Aquaculture Abstracts; Toxicology Abstracts
KW  - pharmacology
KW  - Pisces
KW  - physiology
KW  - X 24114:Metabolism
KW  - H SI6.20:PHARMACEUTICAL INDUSTRIES
KW  - Q3 08581:Aquaculture: General
KW  - Q1 08581:General
KW  - H SE4.20:POISONS AND POISONING
KW  - H SE1.23:FAUNA AND FLORA ECOLOGY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2015-03-24
N1  - SubjectsTermNotLitGenreText - animal physiology; aquatic animals; fish; physiology; pharmacology; absorption; animals; gastrointestinal tract; bioavailability; Pisces
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519945155
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519945079
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944360
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944297
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944297?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1988-01-01&rft.volume=12&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944088
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Estimates of incidence and costs of intestinal infectious diseases in the United States.
AN  - 15186731; 1966791
AB  - The incidence of acute episodes of intestinal infectious diseases in the United States was estimated through analysis of community-based studies and national interview surveys. Their differing results were reconciled by adjusting the study population age distributions in the community-based studies, by excluding those cases that also the reconciliation process provided an estimate of 99 million acute cases of either vomiting or diarrhea, or both, each year in this country, half of which involved more than a full day of restricted activity. The analysis was limited to cases of acute gastrointestinal diseases with vomiting or diarrhea but without respiratory symptoms.
JF  - Public Health Reports
AU  - Garthright, W E
AU  - Archer, D L
AU  - Kvenberg, JE
AD  - HFF-028, FDA, 200 C St. S.W., Washington, DC 20204, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 107
EP  - 115
VL  - 103
IS  - 2
SN  - 0033-3549, 0033-3549
KW  - intestinal diseases
KW  - United States
KW  - Health & Safety Science Abstracts
KW  - surveys
KW  - epidemiology
KW  - economics
KW  - H SM10.25:INTESTINAL DISEASES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15186731?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Estimates+of+incidence+and+costs+of+intestinal+infectious+diseases+in+the+United+States.&rft.au=Garthright%2C+W+E%3BArcher%2C+D+L%3BKvenberg%2C+JE&rft.aulast=Garthright&rft.aufirst=W&rft.date=1988-01-01&rft.volume=103&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - economics; surveys; epidemiology
ER  - 



TY  - JOUR
T1  - Outbreaks of listeriosis/Listeria -contaminated foods.
AN  - 15158330; 1941146
AB  - Outbreaks of food-borne listeriosis in recent years have caused governmental regulatory and health agencies and the food industry to focus on the problem of food contamination by Listeria monocytogenes . A review is presented of the association of L. monocytogenes with human illness and its occurrence in food and the environment.
JF  - Molecular Microbiology
AU  - Kvenberg, JE
AD  - Div. Microbiol., Cent. Food Safety and Appl. Nutr., US FDA, 200 C St., S.W., Washington, DC 20204, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 355
EP  - 358
VL  - 5
IS  - 12
SN  - 0265-1351, 0265-1351
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology
KW  - Listeria monocytogenes
KW  - listeriosis
KW  - reviews
KW  - food
KW  - food poisoning
KW  - A 01017:Human foods
KW  - J 02846:Gastrointestinal tract
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Listeria monocytogenes; reviews; food poisoning; listeriosis; food
ER  - 



TY  - JOUR
T1  - Permanent chondrification in the pelvis and occurrence of hernias in mice treated neonatally with tamoxifen.
AN  - 15130221; 1924760
AB  - Male and female C57BL/Tw mice were given 5 daily subcutaneous injections of 100 mu g tamoxifen (Tx), starting on the day of birth (Tx mice). In untreated fetal mice on day 18 of gestation, the greater part of the public and ischial bones were cartilaginous. At more than 30 days of age, however, untreated mice showed completely calcified pelvic bone, whereas in age-matched Tx mice the greater part of the junctional regions in the pelvis remained cartilaginous. Treatment with Tx starting within 5 days of age caused bladder hernia with or without cecum hernia. The public ligament in Tx mice at age of 30-540 days was markedly expanded as compared with that in age-matched controls. The permanent chondrification in the pelvis was found in all mice given Tx starting within 10 days of age. By contrast, neonatal treatments of mice other antiestrogens, clomiphene and nafoxidine (100 mu g/day), induced neither permanent chondrification in the pelvis nor expansion of the public ligament nor hernia.
JF  - Reproductive Toxicology
AU  - Iguchi, T
AU  - Irisawa, S
AU  - Uchima, F-DA
AU  - Takasugi, N
AD  - Dep. Biol., Yokohama City Univ., Seto 22-2, Kanazawa-ku, Yokohama 236, Japan
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 127
EP  - 134
VL  - 2
IS  - 2
SN  - 0890-6238, 0890-6238
KW  - tamoxifen
KW  - hernia
KW  - chondrification
KW  - mice
KW  - Calcium & Calcified Tissue Abstracts; Toxicology Abstracts
KW  - prenatal experience
KW  - pelvis
KW  - X 24112:Chronic exposure
KW  - T 20018:Cartilage and cartilage diseases
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - prenatal experience; pelvis
ER  - 



TY  - JOUR
T1  - Toxicity assessment of hydrazine fuels.
AN  - 15129109; 1917954
AB  - The major health aspects of exposure to hydrazine propellants are reviewed. Toxic effects of hydrazine fuels on humans and animals as well as in vitro studies are discussed with emphasis on recent findings and USAF studies. Propellant hydrazines have been found to be genotoxic in in vitro studies and oncogenic in animal studies. Embryotoxicity has been demonstrated at very high exposures but not at occupationally encountered levels for hydrazine and unsymmetrical dimethylhydrazine. Epidemiologic evidence to support these findings is lacking; however, the results of animal and in vitro studies have resulted in lowering both the time-weighted average-threshold limit values and short-term exposure limits for these propellants.
JF  - Aviation, Space and Environmental Medicine
AU  - Keller, W C
AD  - FDA/CVM, DHFES (HFV154), 5600 Fishers Lane, Rm. 8-70, Rockville, MD 20857, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - A100
EP  - A106
VL  - 59
IS  - 11
SN  - 0095-6562, 0095-6562
KW  - propellants
KW  - hydrazine
KW  - aerospace medicine
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - toxicity
KW  - fuel technology
KW  - H SM4.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15129109?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space+and+Environmental+Medicine&rft.atitle=Toxicity+assessment+of+hydrazine+fuels.&rft.au=Keller%2C+W+C&rft.aulast=Keller&rft.aufirst=W&rft.date=1988-01-01&rft.volume=59&rft.issue=11&rft.spage=A100&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - toxicity; fuel technology
ER  - 



TY  - JOUR
T1  - Chloroform induction of ornithine decarboxylase antizyme (ODC-AZ) in male rat liver.
AN  - 15128167; 1917744
AB  - Chloroform stimulation of rat hepatic ODC is most dramatic at 18 h following a single injection. Repeated dosing, 1 dose/d for up to 7 d, results in a daily decline in the ability of the liver enzyme to respond 18 h after the final injection. The authors postulated that this decline was due to an increased synthesis and accumulation of the OCD-AZ protein. OCD-AZ was determined by measuring the inhibition of isolated ODC activity as described by Hayashi and Fujita and modified in out laboratory to use kidney ODC. Male and female Fischer 344 rats were injected daily for 1, 3, or 7 d with 3.0 mmol/kg chloroform. Chloroform induced ODC-AZ activity in males at 3 and 7 (26% and 37% inhibitions of the ODC activity in the incubation medium, respectively). While females exhibited a similar decline in ODC activity after repeated doses, ODC-AZ was not induced.
JF  - Journal of Toxicology and Environmental Health
AU  - Savage, RE Jr
AU  - Pereira, MA
AU  - DeAngelo, AB
AD  - Cent. Dis. Control, NIOSH, DBS, ETB, TMS, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 97
EP  - 101
VL  - 25
IS  - 1
SN  - 0093-4108, 0093-4108
KW  - antizymes
KW  - induction
KW  - ornithine decarboxylase
KW  - chloroform
KW  - rats
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - enzymes
KW  - liver
KW  - X 24155:Biochemistry
KW  - H SE4.20:POISONS AND POISONING
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - chloroform; liver; rats; enzymes
ER  - 



TY  - JOUR
T1  - Performance of thick-sorbent diffusive samplers.
AN  - 15118960; 1906375
AB  - Errors of estimates of concentration in the diffusive sampling of analytes weakly bound to finite-thickness sorbents are investigated both theoretically and experimentally. Experimental data are presented for sampling concentration pulses of trichloroethylene, using a column of activated charcoal as sorbent. Analysis indicates that analyte loss results in errors in estimates of 8-h time-weighted averages (TWA) between - 17 and 51%, the extreme values corresponding to short pulses occurring at the beginning or end of the sampling period, respectively. Experiments were also conducted on pulse sampling using a sampler which employs a liquid (in this case, water) column as sorbent. Both acetone (weakly bound) and methanol (more strongly bound) were studied so as to cover a range of physical phenomena. Limits of several mathematical approximations are discussed within the framework of these experiments.
JF  - Annals of Occupational Hygiene
AU  - Bartley, D L
AU  - Woebkenberg, M L
AU  - Posner, J C
AD  - Div. Phys. Sci. and Eng., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 333
EP  - 343
VL  - 32
IS  - 3
SN  - 0003-4878, 0003-4878
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - diffusion
KW  - performance
KW  - activated charcoal
KW  - monitoring instruments
KW  - H SI0.13:INSTRUMENTATION, DEVICES AND CONTROLS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - diffusion; monitoring instruments; activated charcoal; performance; occupational safety
ER  - 



TY  - JOUR
T1  - Occupational biohazards: A review.
AN  - 15080021; 1875380
AB  - There are at least 193 important biological agents that show infectious, allergenic, toxic, or carcinogenic activities in the working population. These agents are viruses, bacteria, fungi, plant substances, invertebrate animals (mostly arthropods), and substances derived from vertebrate animals. At least 20 large occupational groups are exposed to these biohazards. The risk is greatest among health care and laboratory workers who are threatened by human pathogens and among agricultural workers who are at risk from dust-borne biological allergens and toxins and by parasitic worms in warm climates. There is growing evidence that biohazards are also important risk factors for many other professions, including woodworkers, workers of textile plants, sewage and compost workers, miners and renovators.
JF  - American Journal of Industrial Medicine
AU  - Dutkiewicz, J
AU  - Jablonski, L
AU  - Olenchock, SA
AD  - Immunol. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 605
EP  - 623
VL  - 14
IS  - 5
SN  - 0271-3586, 0271-3586
KW  - biology
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational health
KW  - hazards
KW  - risk assessment
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SI0.3:HAZARD DETERMINATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; hazards; risk assessment
ER  - 



TY  - JOUR
T1  - Murine immune response to the Neisseria meningitidis group C capsular polysaccharide. I. Ontogeny.
AN  - 15063625; 1864663
AB  - The immune response to polysaccharide Ag develops late in ontogeny and the underlying mechanisms of the infant unresponsiveness are poorly understood. The development of vaccine that will prove efficacious in infants has been hindered by the lack of animals systems suitable for studying immunity to human pathogens. The authors have examined the BALB/c murine response to the capsular polysaccharide of Neisseria meningitidis group C (MCPS), a homopolymer of alpha (2 9) sialic acid, as a model system for the development of immunity to bacterial polysaccharides in man.
JF  - Journal of Immunology
AU  - Rubinstein, L J
AU  - Stein, KE
AD  - Div. Bact. Prod., CBER, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 4352
EP  - 4356
VL  - 141
IS  - 12
SN  - 0022-1767, 0022-1767
KW  - immune response
KW  - ontogeny
KW  - mice
KW  - polysaccharides
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Neisseria meningitidis
KW  - F 06801:Bacteria
KW  - J 02833:Immune response and immune mechanisms
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Neisseria meningitidis
ER  - 



TY  - JOUR
T1  - Murine immune response to the Neisseria meningitidis group C capsular polysaccharide. II. Specificity.
AN  - 15063097; 1864681
AB  - As a means of further understanding the regulation of diversity and the development of protective immunity to the Neisseria meningitidis group C capsular polysaccharide (MCPS), the authors have generated and characterized, in detail, a panel of mAb against MCPS, a homopolymer of alpha (2 9)-sialic acid. Whereas the serum response to MCPS is restricted to the IgM and IgG3 isotypes, the panel of mAb includes, in addition, both IgG1 and IgG2b. Among 15 mAb of four isotypes, seven different specificities were observed based on direct binding in a fluorescence ELISA and precipitation in gel.
JF  - Journal of Immunology
AU  - Rubinstein, L J
AU  - Stein, KE
AD  - Div. Bact. Prod., CBER, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 4357
EP  - 4362
VL  - 141
IS  - 12
SN  - 0022-1767, 0022-1767
KW  - specificity
KW  - immune response
KW  - mice
KW  - polysaccharides
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Neisseria meningitidis
KW  - F 06801:Bacteria
KW  - J 02833:Immune response and immune mechanisms
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Neisseria meningitidis
ER  - 



TY  - JOUR
T1  - Long workdays versus restdays: Assessing fatigue and alertness with a portable performance battery.
AN  - 15057123; 1845738
AB  - A test battery designed to assess psychological/behavioral fatigue was used to compare restdays to a workweek of five 12-hr days at a data entry job simulation. Across both workdays and restdays, the battery was presented at regular intervals to test for fatigue effects and diurnal variations. Increased data entry errors across the workday and the workweek as well as subjective reports of increased tiredness on workdays indicated that the work regimen was fatiguing. Test battery performance paralleled those results. On workdays, as compared with restdays, grammatical reasoning was faster but less accurate; digit addition was slower; simple, dual, and choice reaction times were slower; and hand steadiness decreased. The results demonstrated the sensitivity of the battery to long hours of work.
JF  - Human Factors
AU  - Rosa, R R
AU  - Colligan, MJ
AD  - NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 305
EP  - 317
VL  - 30
IS  - 3
SN  - 0018-7208, 0018-7208
KW  - fatigue
KW  - Health & Safety Science Abstracts
KW  - performance
KW  - psychology
KW  - human factors
KW  - simulation
KW  - H SI0.7:HUMAN FACTORS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - psychology; simulation; performance; human factors
ER  - 



TY  - JOUR
T1  - Physiological responses to the wearing of fire fighter's turnout gear with neoprene and GORE-TEX) barrier liners.
AN  - 15042086; 1846654
AB  - This study examined the physiological effects of performing moderate and high intensity work while wearing fire fighter's turnout gear with either a neoprene or GORE-TEX) barrier liner. Eight healthy men, experienced with the use of respirators and protective clothing each performed moderate and high intensity treadmill exercise in a double-blind study at 27.6 degree C while wearing complete fire fighter's turnout gear with either a neoprene or GORE-TEX barrier liner. Physiological measurements obtained included minute ventilation, heart rate, skin temperature, rectal temperature and sweat rate. subjective evaluations of perceived exertion, comfort, clothing breathability, temperature and perspiration also were obtained. Tests were terminated when objective or subjective signs of near maximal stress were observed. Mean tolerance times for the moderate intensity exercise were 27.4 ( plus or minus 7.3 S.D.) and 30.9 ( plus or minus 7.9) min, respectively, for the neoprene and GORE-TEX barrier liners and at the high intensity were 7.2 ( plus or minus 2.1) and 7.5 ( plus or minus 2.3) min, respectively.
JF  - American Industrial Hygiene Association Journal
AU  - White, M K
AU  - Hodous, T K
AD  - NIOSH, Div. Res. Dis. Stud., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 523
EP  - 530
VL  - 49
IS  - 10
SN  - 0002-8894, 0002-8894
KW  - GORE-TEX
KW  - firefighter services
KW  - protective materials
KW  - Health & Safety Science Abstracts
KW  - materials testing
KW  - physiology
KW  - H SE8.21:PROTECTIVE MATERIALS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - physiology; materials testing
ER  - 



TY  - JOUR
T1  - Standard morbidity ratios for work-related amputations and fractures by occupation, 1979-1981.
AN  - 15034679; 1845440
AB  - The risk of injury varies with age and sex. Thus, it is possible to draw biased conclusions when considering unadjusted data. Standardized morbidity ratios (SMRs) are summary statements that remove differences in the compositions of the populations under study, permitting unbiased comparisons with respect to certain variables. Workers' compensation data and census data were combined to calculate SMRs for amputations and fractures by occupation. Based on this analysis, occupations were identified that have a high estimated relative risk of amputations (machinists and heavy equipment mechanics) and of fractures (firefighter and plumbers).
JF  - Journal of Safety Research
AU  - Harner, L M
AD  - Data Anal. Sect., Injury Surv. Branch, Div. Saf. Res., NIOSH
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 103
EP  - 113
VL  - 19
IS  - 3
SN  - 0022-4375, 0022-4375
KW  - amputations
KW  - fractures
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - risk assessment
KW  - morbidity
KW  - H SI0.4:ACCIDENT INVESTIGATION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15034679?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Standard+morbidity+ratios+for+work-related+amputations+and+fractures+by+occupation%2C+1979-1981.&rft.au=Harner%2C+L+M&rft.aulast=Harner&rft.aufirst=L&rft.date=1988-01-01&rft.volume=19&rft.issue=3&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - morbidity; occupational safety; risk assessment
ER  - 



TY  - JOUR
T1  - Fate of sulfur(IV) dechlorinating agents in natural waters: Effect of suspended sediments.
AN  - 15026398; 1831276
AB  - To investigate the fate of SO sub(2) in dechlorinated waste water effluents, oxidation rates were measured in nonilluminated solutions at near-neutral pH and 25 degree C. River water was simulated with 0.01 M NaCl, 0.001 M buffer, and 1 g/L standard sediment MESS-1. Components leached from the sediment catalyzed the oxidation of S(IV) by O sub(2), but the particles themselves exerted a slight inhibitory effect. Sulfate was the major reaction product. Some nonoxidative loss of S(IV) to particles was observed at high-sediment concentrations (20 g/L). Sulfur(IV) reductively dissolved 25% of the Cu from the sediment, possibly an environmentally harmful process. Iron and manganese dissolutions were insignificant.
JF  - Environmental Science & Technology
AU  - Kijak, P J
AU  - Helz, G R
AD  - FDA Div. Vet. Med. Res., Build. 328-A, BARC-East, Beltsville, MD 20705, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 1171
EP  - 1177
VL  - 22
IS  - 10
SN  - 0013-936X, 0013-936X
KW  - suspended solids
KW  - natural water
KW  - Pollution Abstracts
KW  - wastewater discharges
KW  - sediments
KW  - P 2000:FRESHWATER POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15026398?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Fate+of+sulfur%28IV%29+dechlorinating+agents+in+natural+waters%3A+Effect+of+suspended+sediments.&rft.au=Kijak%2C+P+J%3BHelz%2C+G+R&rft.aulast=Kijak&rft.aufirst=P&rft.date=1988-01-01&rft.volume=22&rft.issue=10&rft.spage=1171&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - sediments; wastewater discharges
ER  - 



TY  - JOUR
T1  - Vermont granite workers' mortality study.
AN  - 15024131; 1832005
AB  - A cohort mortality study was carried out in Vermont granite workers employed between the years 1950 and 1982, exposed to high levels of granite dust prior to 1938-1940 (average cutters to 40 million parts/cubic foot), and those employed at dust levels after 1940, which on average were less than 10 million parts/cubic foot. Deaths were coded and standardized mortality ratios calculated. The results confirm previous studies that show that death rates from silicosis and tuberculosis, the major health threats before 1940, were essentially eliminated after dust controls. However, the authors found excessive mortality rates from lung cancer in stone shed workers employed prior to 1930, and hence exposed to high levels of granite dust. When information was available, 100% of those dying from lung cancer had been smokers.
JF  - American Journal of Industrial Medicine
AU  - Costello, J
AU  - Graham, WGB
AD  - NIOSH, Rm. 224, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 483
EP  - 497
VL  - 13
IS  - 4
SN  - 0271-3586, 0271-3586
KW  - granite
KW  - carcinoma
KW  - tuberculosis
KW  - man
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - occupational exposure
KW  - lung
KW  - silicosis
KW  - dust
KW  - cancer
KW  - H SM10.39:TUBERCULOSIS
KW  - H SI2.8.7:DUST
KW  - X 24180:Social poisons & drug abuse
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15024131?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Vermont+granite+workers%27+mortality+study.&rft.au=Costello%2C+J%3BGraham%2C+WGB&rft.aulast=Costello&rft.aufirst=J&rft.date=1988-01-01&rft.volume=13&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; dust; silicosis; lung; cancer; carcinoma; tuberculosis; man
ER  - 



TY  - JOUR
T1  - Occupational vitiligo due to unsuspected presence of phenolic antioxidant byproducts in commercial bulk rubber.
AN  - 14983037; 1793755
AB  - The authors investigated the occurrence of cutaneous depigmentation (vitiligo) among employees of a company that manufactured hydraulic pumps. The interiors of these pumps were injection-molded with rubber. We identified a small but significant cluster of vitiligo cases among a group of employees who frequently handled the rubber used in this injection molding process. Although none of the additives specified in the rubber formulations was a phenolic or catecholic derivative, known to be potential causes of chemically induced vitiligo, gas chromatographic analysis identified a para-substituted phenol (2,4-di-tert-butylphenol, DTBP) in solid samples of the most frequently used rubber. Surface wipe analysis confirmed that workers could be exposed to DTBP from simple handling of the rubber.
JF  - J. OCCUP. MED.
AU  - O'Malley, MA
AU  - Mathias, CGT
AU  - Priddy, M
AU  - Molina, D
AU  - Grote, A A
AU  - Halperin, W E
AD  - NIOSH, R-13, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 512
EP  - 516
VL  - 30
IS  - 6
SN  - 0096-1736, 0096-1736
KW  - vitiligo
KW  - by products
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - pigments
KW  - rubber products
KW  - skin
KW  - occupational health
KW  - gas chromatography
KW  - H SM10.38:SKIN DISEASES
KW  - H SI2.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; skin; pigments; gas chromatography; rubber products
ER  - 



TY  - JOUR
T1  - Nutritional factors that may influence bioavailability of cadmium.
AN  - 14981038; 1800739
AB  - Cadmium accumulates slowly in the human body and a critically high level in the kidney can cause damage to the proximal renal tubule. Loss of Ca in the urine then contributes to extensive skeletal mineral loss. The bioavailability of Cd to animals and humans can be markedly affected by nutritional status and dietary intakes of essential and other nutrients. In general, deficiencies and excesses of interacting nutrients exacerbate and protect, respectively, against the adverse effect of Cd. These effects on bioavailability occur primarily via changes in intestinal absorption, although uptake by the kidney sometimes occurs. The chemical form of Cd that is consumed experimentally can also modify response. Many aspects of the relationships between Cd and nutrients are incompletely understood. From studies of population groups with high Cd intakes from certain foods, it appears that consumption of an adequate diet protects markedly against the adverse effects of Cd.
JF  - Journal of Environmental Quality
AU  - Fox
AD  - Nutr. Interaction Sect., Div. Nutr., FDA, 200 C St., S.W., Washington, DC 20204, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 175
EP  - 180
VL  - 17
IS  - 2
SN  - 0047-2425, 0047-2425
KW  - Pollution Abstracts
KW  - nutrition
KW  - fibers
KW  - toxicology
KW  - cadmium
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - nutrition; cadmium; fibers; toxicology
ER  - 



TY  - JOUR
T1  - Application of an air curtain-exhaust system at a milling process.
AN  - 14980266; 1793615
AB  - The purpose of this research was to investigate the air curtain-exhaust ventilation system as an effective control at a rubber milling process. The investigated system consisted of an air curtain and an enclosure added to the existing control. The air curtain was located between the contaminant source and the mill operator to create an air barrier between the operator and the emission source. The enclosure covered the space between the exhaust hood and the mill's back side to eliminate contaminant emission at this space and to increase hood face velocity at the operator side. Laboratory and field test data indicate that a significant reduction in emissions was achieved when this system was operating, even when the existing hood exhaust airflow rate was reduced by 33%.
JF  - American Industrial Hygiene Association Journal
AU  - Hampl, V
AU  - Johnston, O E
AU  - Murdock, DJ Jr
AD  - NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 167
EP  - 175
VL  - 49
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - occupational health
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - laboratory testing
KW  - rubber products
KW  - emission control
KW  - ventilation
KW  - flow rates
KW  - P 0000:AIR POLLUTION
KW  - H SI2.28:RUBBER FACTORIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14980266?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ventilation; rubber products; laboratory testing; flow rates; emission control
ER  - 



TY  - JOUR
T1  - Occupational exposure to silicate fibres and PAHs during sugar-cane harvesting.
AN  - 14978294; 1800793
AB  - The literature has suggested that many commercially important plant species contain amorphous silica. This report provides a summary of that literature as well as the findings from a field survey in Florida of sugar-cane field workers where airborne concentrations of amorphous silica fibres were determined. In addition to the fibre analysis, concentrations of polynuclear aromatic hydrocarbons (PAHs) and total airborne dust were also determined.
JF  - Annals of Occupational Hygiene
AU  - Boeniger, M
AU  - Hawkins, M
AU  - Marsin, P
AU  - Newman, R
AD  - NIOSH, 4676 Columbia Parkw., Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 153
EP  - 169
VL  - 32
IS  - 2
SN  - 0003-4878, 0003-4878
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - fibers
KW  - Florida
KW  - occupational health
KW  - dust
KW  - surveys
KW  - polycyclic aromatic hydrocarbons
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SE2.8.7:DUST
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Florida; occupational health; polycyclic aromatic hydrocarbons; fibers; dust; surveys
ER  - 



TY  - JOUR
T1  - Electrocution at work.
AN  - 14976675; 1792905
AB  - This study was done to examine the factors involved in electrocution in the workplace, using OSHA investigation information in an attempt to analyze the circumstances of injury and to suggest methods of prevention.
JF  - Professional Safety
AU  - Suruda, A
AD  - NIOSH, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 27
EP  - 31
VL  - 33
IS  - 7
SN  - 0099-0027, 0099-0027
KW  - electrocution
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - hazards
KW  - accidents
KW  - occupational health
KW  - H SI10.3:HAZARD DETERMINATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational safety; occupational health; hazards; accidents
ER  - 



TY  - JOUR
T1  - Using the biological two-stage model to assess risk from short-term exposures.
AN  - 14973158; 1799525
AB  - Two assumptions used in risk assessment are investigated: (1) the assumption of fraction of lifetime dose rate assumes that the risk from a fractional lifetime exposure at a given dose rate is equal to the risk from full lifetime exposure at that same fraction of the given dose rate; (2) the assumption of fraction of lifetime risk assumes that the risk from a fractional lifetime exposure at a given dose rate is equal to that same fraction of the risk from full lifetime exposure at the same dose rate. In this paper, the age-specific cumulative hazard functions are derived using the two-stage model developed by Moolgavkar, Venzon, and Knudson for situations when the exposure occurs during a single period or at a single instant. The two assumptions described above are examined for three types of carcinogens, initiator, completer, and promoter, in the context of the model.
JF  - Risk Analysis
AU  - Chen, J J
AU  - Kodell, R L
AU  - Gaylor, D W
AD  - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 223
EP  - 230
VL  - 8
IS  - 2
SN  - 0272-4332, 0272-4332
KW  - dose response effects
KW  - biology
KW  - Pollution Abstracts
KW  - accidents
KW  - carcinogenesis
KW  - mathematical models
KW  - risk assessment
KW  - public health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - risk assessment; accidents; mathematical models; public health; carcinogenesis
ER  - 



TY  - JOUR
T1  - Development of an aerosol dispersion test to detect early changes in lung function.
AN  - 14971997; 1794968
AB  - The dispersion of a 0.5 mu m aerosol bolus during tidal breathing differs significantly between a group of smokers and a comparable group of nonsmokers. Their mean differences in standard respiratory function indexes from spirometry were smaller and not statistically significant. The test is simple to perform and may be done as quickly as spirometry but without using a forced exhalation. Comparison of the coefficients of variation for the dispersion test and FEV sub(1) indicate that the aerosol dispersion test may be useful in epidemiologic investigations either by reducing the required population size or increasing the level of confidence.
JF  - American Industrial Hygiene Association Journal
AU  - McCawley, M
AU  - Lippmann, M
AD  - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 357
EP  - 366
VL  - 49
IS  - 7
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts
KW  - lung
KW  - dispersion
KW  - aerosols
KW  - epidemiology
KW  - H SM3.8.2:CHEMICALS (CORROSION)
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - aerosols; lung; dispersion; epidemiology
ER  - 



TY  - JOUR
T1  - Chemical protective clothing breakthrough time: Comparison of several test systems.
AN  - 14970143; 1794983
AB  - This study compared chemical permeation data obtained with a photo-ionization detector in both open- and closed-loop test systems. Also, chemical permeation data obtained at two flow rates with an infrared detector in a closed-loop test system were compared. Breakthrough times for acetone-neoprene were obtained using all systems. Results were evaluated and determined to be system dependent.
JF  - American Industrial Hygiene Association Journal
AU  - Berardinelli, S P
AU  - Moyer, E S
AD  - DHHS, Public Health Serv., CDC, NIOSH, Div. Saf. Res., Injury Prev. Res. Branch, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 89
EP  - 94
VL  - 49
IS  - 3
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts
KW  - materials testing
KW  - flow rates
KW  - chemical reactions
KW  - monitoring systems
KW  - protective clothing
KW  - H SI6.8.2:CHEMICALS (CORROSION)
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Chemical+protective+clothing+breakthrough+time%3A+Comparison+of+several+test+systems.&rft.au=Berardinelli%2C+S+P%3BMoyer%2C+E+S&rft.aulast=Berardinelli&rft.aufirst=S&rft.date=1988-01-01&rft.volume=49&rft.issue=3&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - chemical reactions; protective clothing; monitoring systems; flow rates; materials testing
ER  - 



TY  - JOUR
T1  - Engineering source controls can reduce worker exposure to noise.
AN  - 14969039; 1792469
AB  - Noise-induced hearing loss has been listed as one of 10 preventable work injuries.
JF  - Occupational Health & Safety
AU  - Haag, WM Jr
AD  - Div. Train. and Manpower Dev., NIOSH, Cincinnati, OH, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 31
EP  - 33
VL  - 57
IS  - 4
SN  - 0362-4064, 0362-4064
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational safety
KW  - occupational health
KW  - hazards
KW  - noise reduction
KW  - pollution control
KW  - P 7000:NOISE
KW  - H SI0.9.8:NOISE (VIBRATION)
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14969039?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Health+%26+Safety&rft.atitle=Engineering+source+controls+can+reduce+worker+exposure+to+noise.&rft.au=Haag%2C+WM+Jr&rft.aulast=Haag&rft.aufirst=WM&rft.date=1988-01-01&rft.volume=57&rft.issue=4&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Occupational+Health+%26+Safety&rft.issn=03624064&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - noise reduction; occupational health; occupational safety; hazards; pollution control
ER  - 



TY  - JOUR
T1  - Occupational injuries due to violence.
AN  - 14965805; 1793309
AB  - Each year in the United States, an estimated 800 to 1,400 people are murdered at work, and an unknown number of non-fatal injuries due to workplace violence occur. Based on Ohio's workers' compensation claims from 1983 through 1985, police officers, gasoline service station employees, employees of the real estate industry, and hotel/motel employees were found to be at the highest risk for occupational violent crime (OVC) injury and death. Grocery store employees, specifically those working in convenience food stores, and employees of the real estate industry had the most reported rapes. Four previously unidentified industries at increased risk of employee victimization were described. Identification of industries and occupations at high risk for crime victimization provides the opportunity to focus preventive strategies to promote employee safety and security in the workplace.
JF  - J. OCCUP. MED.
AU  - Hales, T
AU  - Seligman, P J
AU  - Newman, S C
AU  - Timbrook, CL
AD  - NIOSH, R-21, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 483
EP  - 487
VL  - 30
IS  - 6
SN  - 0096-1736, 0096-1736
KW  - violence
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - risk assessment
KW  - occupational health
KW  - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14965805?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Occupational+injuries+due+to+violence.&rft.au=Hales%2C+T%3BSeligman%2C+P+J%3BNewman%2C+S+C%3BTimbrook%2C+CL&rft.aulast=Hales&rft.aufirst=T&rft.date=1988-01-01&rft.volume=30&rft.issue=6&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational safety; occupational health; risk assessment
ER  - 



TY  - JOUR
T1  - Use of workers' compensation claims data for surveillance of cumulative trauma disorders.
AN  - 14964158; 1793358
AB  - Workers' compensation claims in Ohio were evaluated as a source of surveillance data for identifying workplaces at high risk of cumulative trauma disorders (CTDs) and analyzed for their demographic and industrial characteristics. During a 5-year period (1980 to 1984), 6,849 workers' compensation claims met the case criteria for CTDs. Tenosynovitis due to continuous motion was the most frequently reported condition (58%), and the wrist was the body part most frequently affected (48%). The highest case rate was observed for female workers in the 36 to 45 age group. Incidence rates for individual companies were determined and those with the highest rates for CTDs were identified. The employer-specific rates for CTDs based on workers' compensation claims data can be used as an effective surveillance tool in locating high-risk operations where ergonomic interventions can be implemented to reduce CTD hazards.
JF  - J. OCCUP. MED.
AU  - Tanaka, S
AU  - Seligman, P
AU  - Halperin, W
AU  - Thun, M
AU  - Timbrook, CL
AU  - Wasil, J J
AD  - R-16, NIOSH, CDC, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 488
EP  - 492
VL  - 30
IS  - 6
SN  - 0096-1736, 0096-1736
KW  - compensation
KW  - trauma
KW  - Ohio
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - statistical analysis
KW  - H SI0.4:ACCIDENT INVESTIGATION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14964158?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Use+of+workers%27+compensation+claims+data+for+surveillance+of+cumulative+trauma+disorders.&rft.au=Tanaka%2C+S%3BSeligman%2C+P%3BHalperin%2C+W%3BThun%2C+M%3BTimbrook%2C+CL%3BWasil%2C+J+J&rft.aulast=Tanaka&rft.aufirst=S&rft.date=1988-01-01&rft.volume=30&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational safety; statistical analysis
ER  - 



TY  - PAT
T1  - Enzyme-linked immunosorbent assay (ELISA) for determining anti-bodies against herpes simplex virus (HSV) types 1 and 2 in human sera.
AN  - 14957395; 1782207
AU  - Hampar, B
AU  - Showalter, S D
AU  - Zwieg, M
PY  - 1988
IS  - US Patent 4,764,459
KW  - detection
KW  - antibodies
KW  - enzyme-linked immunosorbent assay
KW  - herpes simplex virus 1
KW  - herpes simplex virus 2
KW  - patents
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts
KW  - W 30050:Patents
KW  - A 01114:Viruses
KW  - W 30507:Diagnostic
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/5; Int. Cl. C12Q 1/70, G01N 33/571, 33/577.
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - NIOSH indoor air quality investigations: 1971 through 1987.
AN  - 14940377; 1768748
AB  - Since 1971, the Hazard Evaluations and Technical Assistance Branch of NIOSH has conducted approximately 500 indoor air quality investigations in a variety of office building environments. These investigations were conducted in response to worker complaints and illness. This paper describes the NIOSH experience in the field of indoor air quality evaluation, the techniques which are used to conduct these types of studies, and presents information regarding major problem areas which have been found to influence the quality of the indoor environments. The problem categories are contamination from inside the building, contamination from outside the building, contamination from the building fabric, microbial contamination, and inadequate ventilation. The NIOSH reports used to compile this information indicate that, although it is not uncommon for more than one type of problem to exist in a single building, inadequacies in ventilation systems, of their operation, are the major contributor to these indoor air quality problems.
AU  - Crandall
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 1
EP  - 112
KW  - Pollution Abstracts
KW  - ventilation
KW  - air quality
KW  - hazards
KW  - indoor environments
KW  - buildings
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - Occupational studies of radon daughters and lung cancer.
AN  - 14940231; 1768764
AB  - Recent discovery of high radon levels in homes in the Northeast, and subsequently in areas across the United States, has stirred interest in the health risks associated with such exposures. Since studies of exposure-response relationships from indoor radom have just recently been initiated, knowledge of potential risks must be derived from occupational mortality studies of underground miners. This presentation describes the findings of five of the major occupational epidemiology studies of uranium and other hard rock mining. Although each study has its limitations, they all show increasing risk of lung cancer with increasing cumulative exposure to the radioactive decay products of radon.
AU  - Hornung, R W
AU  - Ballew, MA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 1
EP  - 105
KW  - Pollution Abstracts
KW  - lung
KW  - risk assessment
KW  - radon
KW  - occupational health
KW  - cancer
KW  - P 0000:AIR POLLUTION
KW  - P 8000:RADIATION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Dermatitis from plastic tote boxes impregnated with an antistatic agent.
AN  - 14908285; 1738412
AB  - An outbreak of dermatitis occurred among employees of a microelectronics firm. In a cross-sectional epidemiologic investigation, the authors found that dermatitis of the hands or arms had occurred among 14 of 29 (48.3%) employees of the incoming inspection department where plastic tote boxes recently purchased from one manufacturer had been used, compared to only one case among 17 (5.9%) employees in another department which had not used these boxes. Affected workers could detect an oily film on the surfaces of these new boxes, but not on older ones. The authors identified the oily film to be a surface accumulation of bis-hydroxyethyl-tallow amine (BHETA), an antistatic agent with which the tote boxes had been impregnated. Subsequent toxicologic investigation established that BHETA could provoke both follicular and nonfollicular irritant dermatitis, and was also a potential skin sensitizer.
JF  - J. OCCUP. MED.
AU  - Bennett, DE
AU  - Mathias, CGT
AU  - Susten, A S
AU  - Fannick, N L
AU  - Smith, AB
AD  - NIOSH, R-13, 4676 Columbia Pkwy., Cinicinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 252
EP  - 255
VL  - 30
IS  - 3
SN  - 0096-1736, 0096-1736
KW  - antistatic agents
KW  - dermatitis
KW  - Health & Safety Science Abstracts
KW  - plastics
KW  - toxicology
KW  - epidemiology
KW  - occupational health
KW  - H SM3.8.2:CHEMICALS (CORROSION)
KW  - H SI6.8.2:CHEMICALS (CORROSION)
KW  - H SM9.8.2:CHEMICALS (CORROSION)
KW  - H SE4.20:POISONS AND POISONING
KW  - H SM6.8.2:CHEMICALS (CORROSION)
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; toxicology; epidemiology; plastics
ER  - 



TY  - JOUR
T1  - Smoking characteristics of US workers, 1978-1980.
AN  - 14894471; 1738065
AB  - Data from the 1978-1980 National Health Interview Survey smoking questionnaire were used to analyze prevalence and levels of cigarette smoking among groups of US workers. This information is valuable for indirect adjustment in occupational epidemiology studies as well as for describing smoking patterns of workers in a wide range of job settings. Although there was a higher percentage of current smokers among men than women in the general population, there were few differences in prevalence of smoking among men and women for specific occupations.
JF  - American Journal of Industrial Medicine
AU  - Brackbill, R
AU  - Frazier, T
AU  - Shilling, S
AD  - NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 5
EP  - 41
VL  - 13
IS  - 1
SN  - 0271-3586, 0271-3586
KW  - Health & Safety Science Abstracts
KW  - cigarettes
KW  - surveys
KW  - occupational health
KW  - H SI0.8.4:DRUGS AND ALCOHOL
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; cigarettes; surveys
ER  - 



TY  - JOUR
T1  - Interferon induction inhibition and mutagenic activity of nitrosated coal dust extract.
AN  - 14880041; 1720240
AB  - Specified cytotoxicity and mutagenicity of coal dust extract (mixture of solvent extractions of bituminous coal nitrosated by NaNO sub(2)) were investigated because of the association of an excess risk of gastric cancer in coal miners. The effect of nitrosated coal dust on a cellular defense component of the interferon system, the induction of interferon ( alpha / beta ) in mammalian cell cultures by influenza virus, and mutagenicity, using the Salmonella)/microsome assay, were determined.
JF  - Environmental Research
AU  - Hahon, N
AU  - Booth, JA
AU  - Stewart, J D
AD  - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 213
EP  - 223
VL  - 45
IS  - 2
SN  - 0013-9351, 0013-9351
KW  - interferon
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - mutation
KW  - occupational health
KW  - coal
KW  - dust
KW  - cancer
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mutation; coal; dust; cancer; occupational health
ER  - 



TY  - PAT
T1  - Cell line producing human monoclonal antibody which binds to HTLV-I producing cells.
AN  - 14838307; 1689303
AU  - Broder, S
AU  - Matsushita, S
AU  - Robert-Guroff, M
PY  - 1988
IS  - US Patent 4,722,888
KW  - production
KW  - specificity
KW  - infected
KW  - cells
KW  - T cell leukemia virus I
KW  - hybridoma
KW  - monoclonal antibodies
KW  - patents
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30050:Patents
KW  - W 30411:Antibodies
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/5; Int. Cl. C12Q 1/70,G01N 33/53,33/577,A61K 39/42.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Hazards of working in cold weather include frostbite, hypothermia.
AN  - 14836598; 1685228
AB  - Treatment for frostbite may be complex, including procedures to prevent infection.
JF  - Occupational Health & Safety
AU  - Sinks, T
AD  - Div. Surveill., Hazard Eval. and Field Stud., NIOSH, Cincinnati, OH 45226 USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 20
EP  - 20, 22, 25
VL  - 57
IS  - 2
SN  - 0362-4064, 0362-4064
KW  - frostbite
KW  - hypothermia
KW  - Health & Safety Science Abstracts
KW  - hazards
KW  - occupational health
KW  - H SI0.9.3:COLD
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; hazards
ER  - 



TY  - PAT
T1  - Synthetic peptides for the production of specific keratin protein antibodies.
AN  - 14829755; 1689348
AU  - Steinert, P M
AU  - Roop
AU  - Yuspa, SH
PY  - 1988
IS  - US Patent 4,722,895
KW  - peptide synthesis
KW  - keratin
KW  - monoclonal antibodies
KW  - patents
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30050:Patents
KW  - W 30411:Antibodies
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/68; Int. Cl. C12P 21/00,21/02, C12N 15/00, C12Q 1/00.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - An exploratory analysis of excavation cave-in fatalities.
AN  - 14827569; 1684301
AB  - A combination of economic incentives, clarification and enforcement of current standards, and society's emerging acceptance of criminal penalties for willful violations of safety and health standards may change the unsafe practices currently prevalent in the construction industry.
JF  - Professional Safety
AU  - Stanevich, R L
AU  - Middleton, D C
AD  - Div. Saf. Res., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888 USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 24
EP  - 28
VL  - 33
IS  - 2
SN  - 0099-0027, 0099-0027
KW  - excavation
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - construction industry
KW  - economics
KW  - occupational health
KW  - H SI1.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - construction industry; economics; occupational health; occupational safety
ER  - 



TY  - JOUR
T1  - Case-control study of lung cancer in civilian employees at the Portsmouth Naval Shipyard, Kittery, Maine.
AN  - 14826827; 1685185
AB  - Case-control analysis of deaths due to lung cancer (International Classification of Diseases, Eighth Revision, code 162) among persons who worked at the Portsmouth Naval Shipyard, Kittery, Maine, between 1952 and 1977 found elevated odds ratios for exposures to ionizing radiation, asbestos, and welding by-products. The radiation-related excess was statistically significant in persons with cumulative lifetime exposures of 1.0-4.999 rem. When asbestos and welding histories were combined into a single risk factor, odds ratios for the combined exposure were significantly elevated for two of three duration-of-exposure categories examined.
JF  - American Journal of Epidemiology
AU  - Rinsky, R A
AU  - Melius, J M
AU  - Hornung, R W
AU  - Zumwalde, R D
AU  - Waxweiler, R J
AU  - Landrigan, P J
AU  - Bierbaum, P J
AU  - Murray, WE Jr
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 55
EP  - 64
VL  - 127
IS  - 1
SN  - 0002-9262, 0002-9262
KW  - asbestos
KW  - Maine, Kittery, Portsmouth Naval Shipyard
KW  - respiratory pathology
KW  - carcinoma
KW  - man
KW  - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - welding
KW  - ionizing radiation
KW  - occupational exposure
KW  - lung
KW  - cancer
KW  - H SM3.9.1:RADIATION HAZARDS
KW  - X 24210:Radiation & radioactive materials
KW  - H SM6.9.1:RADIATION HAZARDS
KW  - H SI2.9.1:RADIATION HAZARDS
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - lung; cancer; welding; asbestos; ionizing radiation; respiratory pathology; occupational exposure; carcinoma; man
ER  - 



TY  - JOUR
T1  - Occupational Arena: "Flying High but Sober"
AN  - 1474330234
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 228
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Comparing Peer-Led to Teacher-Led Youth Alcohol Education in Four Countries
AN  - 1474330229
JF  - Alcohol Health and Research World
AU  - Perry, Cheryl L
AU  - Grant, Marcus
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 322
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Nurturing an Infant Science: The Extramural Research Program
AN  - 1474330225
JF  - Alcohol Health and Research World
AU  - Pawlowski, Albert
AU  - Chatham, Lois
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 258
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Can Treatment Outcome Research Rely on Alcoholics' Self-Reports?
AN  - 1474330066
AB  - Former patients' claims of current abstinence may not be scientifically credible
JF  - Alcohol Health and Research World
AU  - Fuller, Richard K
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 180
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - What Is Appropriate Treatment Duration, and For Whom? An Interview With Edward Gottheil
AN  - 1474329923
AB  - An overview of the treatment outcome literature and a key problem area
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL J
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 188
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - What Purchasers of Treatment Services Want From Evaluation: A State Government Perspective
AN  - 1474329813
AB  - How Michigan plans to be a more informed buyer
JF  - Alcohol Health and Research World
AU  - Allo, Clifford D
AU  - Mintzes, Barry
AU  - Brook, Robert C
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 162
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Disulfiram: An Evaluation Research Model
AN  - 1474329608
AB  - Problems in examining the effectiveness of the leading alcoholism medication
JF  - Alcohol Health and Research World
AU  - McNichol, Ronald W
AU  - Logsdon, Steven A
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 202
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Perspectives
AN  - 1474329458
JF  - Alcohol Health and Research World
AU  - Blume, Sheila B
AU  - Nathan, Peter E
AU  - Olson, Lois
AU  - Lieber, Charles S
AU  - Anonymous
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 302
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Defining Desirable Treatment Outcomes
AN  - 1474329432
AB  - Clinicians try to categorize the end product of therapy
JF  - Alcohol Health and Research World
AU  - Frawley, P Joseph
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 210
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Winning Victories Over Myths-Perceptions
AN  - 1474329199
JF  - Alcohol Health and Research World
AU  - Funkhouser, Judith E
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 278
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Making It Happen: Advocacy for the Hughes Act
AN  - 1474327812
JF  - Alcohol Health and Research World
AU  - SMITHERS, R BRINKLEY
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 271
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Readers' Exchange: "Impaired-Driving Arrests of Women Over a Five-Year Period"
AN  - 1474326759
JF  - Alcohol Health and Research World
AU  - Shore, Elsie R
AU  - McCoy, Marcia L
AU  - Martin, Lynn M
AU  - Kuntz, E J
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 224
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Conflict Between Personal Ideology and and Prevention Programs
AN  - 1474326672
JF  - Alcohol Health and Research World
AU  - O' Gorman, Patricia A
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 298
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Hearing Room Dreams and the Birth of NIAAA
AN  - 1474326589
JF  - Alcohol Health and Research World
AU  - Pike, Thomas R
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 268
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Intramural Research at NIAAA
AN  - 1474325482
JF  - Alcohol Health and Research World
AU  - Tabakoff, Boris
AU  - Petersen, Robert C
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 252
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Key Issues in Treatment Outcome Studies
AN  - 1474325464
AB  - Two respected authorities suggest techniques to improve research
JF  - Alcohol Health and Research World
AU  - Longabaugh, Richard
AU  - Lewis, David C
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 168
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Congressional Rites of Passage for the Rights of Alcoholics
AN  - 1474325461
JF  - Alcohol Health and Research World
AU  - Lewis, Jay S
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 240
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Musings on the Art of Treatment
AN  - 1474324645
JF  - Alcohol Health and Research World
AU  - Weisman, Maxwell N
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 282
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Milestones
AN  - 1474324131
JF  - Alcohol Health and Research World
AU  - Gordis, Enoch
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 236
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - From the Desk of Will Foster, Jr.
AN  - 1474323899
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 274
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Occupational Arena: "EAP's: Notes for a History in Progress"
AN  - 1474323882
JF  - Alcohol Health and Research World
AU  - Bickerton, Richard L
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 316
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Special Populations: "Japanese-American Drinking - Some Results From the Joint Japanese-U.S. Alcohol Epidemiology Project"
AN  - 1474323855
JF  - Alcohol Health and Research World
AU  - Towle, Leland H
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 216
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 19 The Alcohol Surveillance Program of the Division of Biometry and Epidemiology: History, Growth, and Future Directions
AN  - 1474323709
JF  - Alcohol Health and Research World
AU  - Harford, Thomas C
AU  - Zobeck, Terry S
AU  - Grant, Bridget F
AU  - Stinson, Frederick S
AU  - Aitken, Sherrie S
AU  - Dufour, Mary
AU  - STOIL, MICHAEL J
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 309
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The National Alcohol Research Centers Program
AN  - 1474323681
JF  - Alcohol Health and Research World
AU  - Pawlowski, Albert
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 262
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Evaluating Professional Counseling in Alcoholism Treatment
AN  - 1474323665
AB  - What's important in successful use of "talking therapies"?
JF  - Alcohol Health and Research World
AU  - Swisher, John D
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 176
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Foreword
AN  - 1474323657
JF  - Alcohol Health and Research World
AU  - Hughes, Harold E
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 234
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Keep Coming Back: The Case for a Valuation of Alcoholics Anonymous
AN  - 1474303112
AB  - Has any study entirely captured the program's effects?
JF  - Alcohol Health and Research World
AU  - Bradley, Ann M
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 192
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports: "Laboratory Research in Advance of Clinical Trials"
AN  - 1474302858
JF  - Alcohol Health and Research World
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 229
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Comments on the Science of Treatment Research An Interview with Roger E. Meyer and Thomas F. Babor
AN  - 1474302657
JF  - Alcohol Health and Research World
AU  - Bradley, Ann M
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 288
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - On NIAAA: Background and Perspective
AN  - 1474301732
JF  - Alcohol Health and Research World
AU  - Keller, Mark
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 269
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Beyond Prohibition: The Public Health Approach to Prevention
AN  - 1474301482
JF  - Alcohol Health and Research World
AU  - Holder, Harold D
AU  - STOIL, MICHAEL J
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 292
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Origins and Development of Federal Support for Alcohol Research
AN  - 1474300937
JF  - Alcohol Health and Research World
AU  - Straus, Robert
Y1  - 1988/01/01/
PY  - 1988
DA  - 1988 Jan 01
SP  - 272
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Health in a City. Working between Hope and Illusion. The Healthy Cities Project in Bremen
AN  - 1463024273; 199001056
AB  - A description of the development of the Healthy Cities project, initited in 1987 by the World Health Organization in the city of Bremen, Federal Republic of Germany. Steps at the political & institutional levels necessary for implementation are chronicled, along with the establishment of a new intersectoral working group & planned projects. Multisectoral action is necessary in order to address ecological, economic, social, demographic, & town planning problems. The aim is to make such action visible, & to make Bremen accessible for the disabled, reduce inequalities between districts, & create opportunities for children & older people to lead a satisfying & healthy life. 7 Figures. Modified HA
JF  - Innovation
AU  - Hilbert, Thomas
AD  - Public Health Service, Horner Str 60-70 D-2800 Bremen 1 Federal Republic Germany
Y1  - 1988///0,
PY  - 1988
DA  - 0, 1988
SP  - 229
EP  - 245
VL  - 1
IS  - 2-3
SN  - 1351-1610, 1351-1610
KW  - Healthy Cities Project implementation/goals, Bremen, Federal Republic of Germany
KW  - case study
KW  - Cities
KW  - Public Health
KW  - Educational Programs
KW  - Federal Republic of Germany
KW  - article
KW  - 6124: social welfare
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LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2013-12-01
N1  - Last updated - 2016-09-28
N1  - SubjectsTermNotLitGenreText - Federal Republic of Germany; Cities; Public Health; Educational Programs
ER  - 



TY  - JOUR
T1  - Microbial metabolism of polycyclic aromatic hydrocarbons: isolation and characterization of a pyrene-degrading bacterium
AN  - 13775168; 198900352
AB  - Microcosm tests on sediment and water samples from 3 sites exposed to petrogenic chemicals showed that mineralization of radiolabelled pyrene after a 2-3 week lag phase was inversely proportional to the distance from the point source of contamination. A pyrene-degrading bacterium isolated from sediment collected at the site nearest to the point source was identified as a Mycobacterium sp. which exhibited optimal growth at 24-30C and up to 4 per cent salt concentration. In experiments on the induction of pyrene mineralization, lag phases were observed in non-induced Mycobacterium sp. cultures, and no mineralization occurred in uninduced cultures grown in the presence of the bacterial protein synthesis inhibitor chloramphenicol, demonstrating that inducible enzymes were responsible for pyrene degradation. Pure cultures of Mycobacterium sp. also mineralized other PAH containing 2, 3 or 4 fused aromatic rings and several nitrated or alkylated PAH. There are 45 references.
JF  - Applied and Environmental Microbiology
AU  - Heitkamp, MA
AU  - Franklin, W
AU  - Cerniglia, CA
AD  - National Center for Toxicological Research, Jefferson, Ark.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 2549
EP  - 2555
VL  - 54
IS  - 10
SN  - 0099-2240, 0099-2240
KW  - Enzymes (see also individual groups below)
KW  - Aqualine Abstracts
KW  - AQ 00007:Industrial Effluents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - 1H-NMR spectra of the 22 tetrachlorinated dibenzo-p-dioxins
AN  - 13768365; S199029887
AB  - Tabulated and graphical results are presented from a study to determine the nuclear magnetic resonance (NMR) spectra for Twenty two tetrachlorinated dibenzo-p-dioxin prepared by reacting the dipotassium salt of a chlorinated catechol with a chlorinated benzene or an ortho-chlorinated nitrobenzene. In view of the uniqueness of these spectra it was concluded that NMR spectroscopy would be an efficient means for isomer-specific determination of traces of these components.
JF  - Chemosphere
AU  - Gelbaum, L T
AU  - Patterson, D G
AU  - Ashley, D L
AU  - Groce, D F
AD  - U.S. Department of Health and Human Services, Atlanta, Ga.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 551
EP  - 558
VL  - 17
IS  - 3
SN  - 0045-6535, 0045-6535
KW  - Aqualine Abstracts
KW  - AQ 00008:Effects of Pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - A liquid chromatographic study of the effect of adsorption on the concentration of aqueous temephos solutions
AN  - 13763771; 198903815
AB  - Temephos, the organophosphorus insecticide 0,0,0,0-tetramethyl 0,0-thiodi-p-phenylene phosphorothioate was analysed by reversed phase high performance liquid chromatography in 5 ml water with UV detection at 254 nm. The method was accurate and reliable for measuring 0.005-5.0 ppm temephos. The detection limit was 1 ng. The standard curve was not linear over the entire range; separate curves were required for concentrations above and below 0.1 ppm. Non-silanized glass containers adsorbed less temephos than silanized glass or plastic. For solutions of 0.01 ppm or less, adsorption effects were minimized by using non-silanized glass containers with a surface area/volume ratio of approximately 130 mm2 per ml (equivalent to a 50 ml beaker), in which a relatively constant concentration of temephos could be maintained for several hours.
JF  - Journal of Liquid Chromatography
AU  - Dickinson, C M
AU  - Sullivan, J J
AU  - Allen, C R
AD  - U.S. Department of Health and Human Services, Atlanta, Ga.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 3435
EP  - 3446
VL  - 11
IS  - 16
SN  - 0148-3919, 0148-3919
KW  - Analysis
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Human exposure to polychlorinated biphenyls at toxic waste sites: investigation in the United States
AN  - 13762509; 199000038
AB  - The impact on human health of exposure to polychlorinated biphenyls (PCB) was evaluated by pilot studies at 12 waste disposal sites with PCB contamination of up to 2.5 ppb in groundwater and 330,000 ppb in soil samples. Serum PCB concentrations of population groups of 9-14 individuals at high risk of non-occupationally related exposure were within the background concentration range at eight sites. Possible causes for the relatively high proportion of people with serum PCB concentrations above 20 ppb at the two remaining sites included the historical prevalence of occupationally-related exposure, and contamination of the maritime food chain; exposure rates at both sites would be investigated by community surveys. Adverse health effects could not be attributed to waste site chemicals unless uptake occurred, but potential health risks could depend on the characteristics of wastes and the activities and composition of the resident population.
JF  - Archives of Environmental Health
AU  - Stehr-Green, P A
AU  - Burse, V W
AU  - Welty, E
AD  - U.S. Department of Health and Human Services, Atlanta, Ga.
Y1  - 1988
PY  - 1988
DA  - 1988
SP  - 420
EP  - 424
VL  - 43
IS  - 6
SN  - 0003-9896, 0003-9896
KW  - Hazard
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Case Study.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - CHEMICAL STOCKPILE DISPOSAL PROGRAM, ALABAMA, ARKANSAS, COLORADO, INDIANA, KENTUCKY, MARYLAND, OREGON, UTAH, AND POTENTIALLY TRAVERSED STATES.
AN  - 36388051; 1652
AB  - PURPOSE: Destruction of the United States stockpile of unitary lethal chemical agents and munitions by September 30, 1994 is proposed in conjunction with the acquisition of binary chemical weapons. The majority of the stockpile is stored at eight Army installations, located at Aberdeen Proving Ground near Edgewood, Maryland; Anniston Army Depot near Anniston, Alabama; Lexington-Blue Grass Army Depot near Richmond, Kentucky; Newport Army Ammunition Plant near Newport, Indiana; Pine Bluff Arsenal near Pine Bluff, Arkansas; Pueblo Depot Activity near Pueblo, Colorado; Tooele Army Depot near Tooele, Utah; and Umatilla Depot Activity near Hermiston, Oregon. Chemical agents included in the stockpile are of two basic types, namely, nerve and blistering agents. More specifically, the munitions include 105-millimeter (mm) mustard gas projectiles, 155-mm mustard gas projectiles, 4.2-inch mustard gas mortar shells, ton containers of mustard gas, 105-mm agent GB projectiles, 155-mm projectiles containing agent GB and agent VX, 8-inch projectiles of GB and VX, M55 rocket projectiles of GB and VX, 500- and 750-pound bombs containing GB, Weteye bombs containing GB, M23 land mines containing VX, spray tanks of VX, and ton containers of VX and GB. All of the agents are at least 19 years old, and some are more than 40 years old. The preferred disposal would involve on-site disposal of the unitary stockpile at each existing site. On-site movement of munitions between the current storage locations and the disposal facilities would be required; however, only small quantities would be moved at any one time. For each site, disposal facilities would have to be constructed or modified, operated, and then decommissioned. POSITIVE IMPACTS: Destruction of the stockpile would reduce the period of time that portions of the U.S. population would be at risk of accidental exposure to the chemical agents. The Army would implement an intergovernmental consultation and coordination process to facilitate state and local government awareness of this program and a technical assistance program to improve emergency response capabilities of affected states and communities. On-site disposal would pose fewer risks of human health impacts than any other alternative scheme considered. NEGATIVE IMPACTS: Some members of the public would be at risk for a period of up to eight years. In addition to those hazards derived from short-term storage of the inventory at its existing location, other hazards could result from handling, temporary storage at the disposal facilities, on-site transportation, disposal plant operations, and external events. Impacts to the physical, biological, and human environments would result in the event of an accident. Certain land uses would be foregone, and wildlife habitat would be displaced. LEGAL MANDATES: Department of Defense Authorization Act of 1984 (P.L. 99-145), Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.), Hazardous Materials Transportation Act (49 U.S.C. 1801 et seq.), and Resource Conservation and Recovery Act of 1976, as amended (42 U.S.C. 6901 et seq.). PRIOR REFERENCES: For the abstract of the draft environmental impact statement, see 86-0298D, Volume 10, Number 7.
JF  - EPA number: 870461, 3 volumes, December 30, 1987
PY  - 1987
KW  - Wastes
KW  - Air Quality
KW  - Chemical Agents
KW  - Disposal
KW  - Emissions
KW  - Endangered Species (Animals)
KW  - Health Hazards
KW  - Land Use
KW  - Military Facilities (Army)
KW  - Mines
KW  - Missiles
KW  - Munitions
KW  - Particulates
KW  - Safety
KW  - Storage
KW  - Water Quality
KW  - Weapon Systems
KW  - United States
KW  - Department of Defense Authorization Act of 1984, Project Authorization
KW  - Federal Water Pollution Control Act of 1972, Compliance
KW  - Hazardous Materials Transportation Act, Compliance
KW  - Resource Conservation and Recovery Act of 1976, Compliance
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Name - Department of the Army, Program Manager for Chemical Demilitarization, Aberdeen Proving Ground, Maryland; ARMY
N1  - Date revised - 2006-05-01
N1  - SuppNotes - Final. Preparation date: December 30, 1987
N1  - Last updated - 2011-12-16
ER  - 



TY  - JOUR
T1  - Structural characterization of pertussis toxin A subunit.
AN  - 77883208; 3320046
AB  - The relationship between the structure of the A subunit of pertussis toxin and its function was analyzed. Limited tryptic digestion of the A subunit converted the protein to two stable fragments (Mr = 20,000 and 18,000). Antibodies raised to synthetic peptides homologous to regions in the A subunit were used to map these fragments. Both fragments were shown to contain the NH2-terminal portion but not the COOH-terminal portion of the A subunit. While these fragments exhibited NAD glycohydrolase activity, they were unable to reassociate with the B oligomer of the toxin. Thus the COOH-terminal portion of the A subunit does not contain the residues which are required for the NAD glycohydrolase activity of the toxin. However, this region of the molecule may be important for maintaining the oligomeric structure of the toxin. These results suggest that the A subunit of pertussis toxin is similar in structure to the A subunit of cholera toxin. In addition, antibodies raised to a synthetic peptide identical to residues 6-17 of the A subunit of pertussis toxin will bind to the A subunit of cholera toxin.
JF  - The Journal of biological chemistry
AU  - Burns, D L
AU  - Hausman, S Z
AU  - Lindner, W
AU  - Robey, F A
AU  - Manclark, C R
AD  - Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland 20892.
Y1  - 1987/12/25/
PY  - 1987
DA  - 1987 Dec 25
SP  - 17677
EP  - 17682
VL  - 262
IS  - 36
SN  - 0021-9258, 0021-9258
KW  - Antibodies
KW  - 0
KW  - Peptide Fragments
KW  - Virulence Factors, Bordetella
KW  - Cholera Toxin
KW  - 9012-63-9
KW  - Pertussis Toxin
KW  - EC 2.4.2.31
KW  - N-Glycosyl Hydrolases
KW  - EC 3.2.2.-
KW  - NAD+ Nucleosidase
KW  - EC 3.2.2.5
KW  - Trypsin
KW  - EC 3.4.21.4
KW  - Index Medicus
KW  - Animals
KW  - Peptide Mapping
KW  - N-Glycosyl Hydrolases -- metabolism
KW  - Trypsin -- metabolism
KW  - Mice
KW  - Immunosorbent Techniques
KW  - Molecular Weight
KW  - Protein Conformation
KW  - Binding Sites
KW  - Peptide Fragments -- metabolism
KW  - Virulence Factors, Bordetella -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-29
N1  - Date created - 1988-01-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype.
AN  - 81113056; 3677322
AB  - A genetic polymorphism in the enzymatic N-acetylation of sulfamethazine and other drugs in humans is well known and has been related to differential susceptibility to drug toxicities. Carcinogenic aromatic amines such as 2-aminofluorene also undergo N-acetylation, and phenotypic slow acetylator individuals have been suggested to be at increased risk to arylamine-induced urinary bladder cancer. However, acetyltransferases have also been shown to catalyze a final metabolic activation step in the conversion of both hydroxamic acid (e.g. N-hydroxy-N-acetyl-2-aminofluorene N,O-acyltransferase) and N-hydroxy-arylamine (e.g. N-hydroxy-2-aminofluorene O-acetyltransferase) metabolites to DNA-bound adducts. In this regard, rapid acetylators have recently been reported to be at higher risk for colorectal cancer. In this study, we examined the enzymatic activity of 35 human liver cytosol samples (obtained surgically from organ donors) for sulfamethazine and 2-aminofluorene N-acetyltransferase activities, N-hydroxy-N-acetyl-2-aminofluorene N,O-acyltransferase activity, and the acetyl coenzyme A (CoA)-dependent O-acetylation of N-hydroxy-2-aminofluorene to form DNA-bound products. The results with sulfamethazine indicated that about two-thirds of the human liver samples were of the slow acetylator phenotype; the same individuals also exhibited levels of 2-aminofluorene N-acetylation that were consistent with their respective sulfamethazine-N-acetylation activity. N-Hydroxy-N-acetyl-2-aminofluorene N,O-acyltransferase activity was not detected. However, the acetyl CoA-dependent activation of N-hydroxy-2-aminofluorene was observed for nearly all of the samples and was consistently higher in the fast acetylator group. These data support the hypothesis that phenotypic rapid acetylator individuals are likely to be at higher risk to aromatic amine-induced cancers in those tissues containing appreciable levels of N-hydroxy arylamine O-acetyltransferase.
JF  - Carcinogenesis
AU  - Flammang, T J
AU  - Yamazoe, Y
AU  - Guengerich, F P
AU  - Kadlubar, F F
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 1967
EP  - 1970
VL  - 8
IS  - 12
SN  - 0143-3334, 0143-3334
KW  - Fluorenes
KW  - 0
KW  - Isoenzymes
KW  - N-hydroxy-2-aminofluorene
KW  - 61M94X4V24
KW  - Acetyl Coenzyme A
KW  - 72-89-9
KW  - Acetyltransferases
KW  - EC 2.3.1.-
KW  - Arylamine N-Acetyltransferase
KW  - EC 2.3.1.5
KW  - Index Medicus
KW  - Phenotype
KW  - Polymorphism, Genetic
KW  - Biotransformation
KW  - Humans
KW  - In Vitro Techniques
KW  - Acetyltransferases -- metabolism
KW  - Fluorenes -- pharmacokinetics
KW  - Liver -- metabolism
KW  - Acetyl Coenzyme A -- metabolism
KW  - Isoenzymes -- genetics
KW  - Arylamine N-Acetyltransferase -- metabolism
KW  - Isoenzymes -- metabolism
KW  - Arylamine N-Acetyltransferase -- genetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-05
N1  - Date created - 1988-01-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Tumorigenic responses to lindane in mice: potentiation by a dominant mutation.
AN  - 81112981; 2445499
AB  - Obese mottled yellow Avy/a, lean pseudoagouti Avy/a and lean black a/a (YS X VY) F-1 hybrid female mice were fed diet containing 160 p.p.m. lindane (gamma-hexachlorocyclohexane) for 6, 12, 18 or 24 months. Clara cell hyperplasia was present in a majority of the mice after six months of lindane ingestion; however, more yellow mice (77%) than pseudoagouti (50%) or black (56%) mice had developed this lesion. Continued ingestion of lindane increased the incidence of Clara cell hyperplasia and resulted in similar prevalences in the three phenotypes. Lung tumors associated with lindane ingestion for 24 months were found only in yellow (19%) and pseudoagouti (14%) mice but not in the black mice. Prevalences of hepatocellular adenomas and carcinomas were very low (less than 10%) in untreated pseudoagouti and black mice. Lindane ingestion for 24 months resulted in an hepatocellular adenoma prevalence of 12% in pseudoagouti mice and 3% in black mice; comparable hepatocellular carcinoma prevalences were 5% and 1%. Among yellow mice fed lindane diet for 24 months, adenoma prevalence was 35% (9% among untreated controls) but carcinoma prevalence was only 17% (13% among controls). The tumorigenic responses evoked by lindane feeding in the lean pseudoagouti Avy/a mice but not in the black a/a mice indicate, for the first time, that the Avy gene itself, in the absence of obesity, sensitizes cells to transformation. The greater prevalence of hepatocellular adenomas in obese yellow Avy/a than in lean pseudoagouti Avy/a mice implicates obesity-associated factors in tumor promotion. Similarly, the increased prevalence of hepatocellular carcinomas in untreated obese yellow Avy/a mice, as compared to lean pseudoagouti mice, implicates obesity-associated factor as favoring histiotypic progression of liver tumors. Thus, the Avy gene not only sensitizes cells to respond to tumorigenic stimuli but also, by the induction of obesity, enhances promotion and progression of transformed cells.
JF  - Carcinogenesis
AU  - Wolff, G L
AU  - Roberts, D W
AU  - Morrissey, R L
AU  - Greenman, D L
AU  - Allen, R R
AU  - Campbell, W L
AU  - Bergman, H
AU  - Nesnow, S
AU  - Frith, C H
AD  - National Center for Toxicological Research, Food and Drug Administration, Department of Health and Human Services, Jefferson, AR 72079.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 1889
EP  - 1897
VL  - 8
IS  - 12
SN  - 0143-3334, 0143-3334
KW  - Lindane
KW  - 59NEE7PCAB
KW  - Index Medicus
KW  - Animals
KW  - Liver Neoplasms, Experimental -- chemically induced
KW  - Mice
KW  - Organ Size
KW  - Rats, Inbred Strains
KW  - Eating
KW  - Rats
KW  - Liver Neoplasms, Experimental -- pathology
KW  - Adenoma -- chemically induced
KW  - Lung Neoplasms -- chemically induced
KW  - Adenoma -- pathology
KW  - Female
KW  - Lung Neoplasms -- pathology
KW  - Lindane -- pharmacology
KW  - Mutation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-05
N1  - Date created - 1988-01-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - In vivo and in vitro formation of glutathione conjugates from the K-region epoxides of 1-nitropyrene.
AN  - 81109179; 3677304
AB  - 4,5-Epoxy-4,5-dihydro-1-nitropyrene (1-nitropyrene 4,5-oxide) and 9,10-epoxy-9,10-dihydro-1-nitropyrene (1-nitropyrene 9,10-oxide), which are electrophilic metabolites formed during the metabolism of the environmental pollutant, 1-nitropyrene, reacted slowly with glutathione. The rate of conjugation was greatly enhanced by the addition of purified rat liver glutathione (GSH) transferases, with transferases 3-3 and 4-4 exhibiting higher catalytic activities than transferases 1-1, 2-2 and 7-7. Two GSH conjugates were formed from each of the oxides: 1-nitropyrene 4,5-oxide gave a 1:1 mixture of 4-(glutathion-S-yl)-5-hydroxy-4,5-dihydro-1-nitropyrene and 5-(glutathion-S-yl)-4-hydroxy-4,5-dihydro-1-nitropyrene while 1-nitropyrene 9,10-oxide gave a 2:1 mixture of 9-(glutathion-S-yl)-10-hydroxy-9,10-dihydro-1-nitropyrene and 10-(glutathion-S-yl)-9-hydroxy-9,10-dihydro-1-nitropyrene. Both K-region oxides were converted to trans-dihydrodiols by hepatic microsomal epoxide hydrase, and faster rates were observed with 1-nitropyrene 4,5-oxide. In subsequent experiments [4,5,9,10-3H]1-nitropyrene was administered to Sprague-Dawley rats by intravenous and intraperitoneal injections. HPLC analysis of biliary metabolites indicated the presence of four GSH conjugates that were identical to those obtained from reactions of the K-region oxides with GSH. In addition, glucuronide conjugates were detected from trans-4,5-dihydroxy-4,5-dihydro-1-nitropyrene (1-nitropyrene trans-4,5-dihydrodiol) but not trans-9,10-dihydroxy-9,10-dihydro-1-nitropyrene (1-nitropyrene trans-9,10-dihydrodiol). These data combined with earlier studies indicate that 1-nitropyrene is oxidized preferentially to 1-nitropyrene 4,5-oxide and that, while the main detoxification pathway of 1-nitropyrene 9,10-oxide is GSH conjugation, 1-nitropyrene 4,5-oxide is excreted via both GSH conjugation and dihydrodiol formation followed by O-glucuronidation.
JF  - Carcinogenesis
AU  - Djurić, Z
AU  - Coles, B
AU  - Fifer, E K
AU  - Ketterer, B
AU  - Beland, F A
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 1781
EP  - 1786
VL  - 8
IS  - 12
SN  - 0143-3334, 0143-3334
KW  - Epoxy Compounds
KW  - 0
KW  - Ethers, Cyclic
KW  - Pyrenes
KW  - Glutathione Transferase
KW  - EC 2.5.1.18
KW  - Glutathione
KW  - GAN16C9B8O
KW  - 1-nitropyrene
KW  - TD1665I8Q4
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Chemistry
KW  - Microsomes, Liver -- metabolism
KW  - Glutathione Transferase -- metabolism
KW  - Chemical Phenomena
KW  - Bile -- metabolism
KW  - Male
KW  - Chromatography, High Pressure Liquid
KW  - Ethers, Cyclic -- metabolism
KW  - Glutathione -- metabolism
KW  - Pyrenes -- metabolism
KW  - Epoxy Compounds -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-05
N1  - Date created - 1988-01-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Carcinogen-DNA adduct formation in the lungs and livers of preweanling CD-1 male mice following administration of [3H]-6-nitrochrysene, [3H]-6-aminochrysene, and [3H]-1,6-dinitropyrene.
AN  - 81109074; 3677076
AB  - 6-Nitrochrysene (NC) and 6-aminochrysene (AC) have been shown to be potent lung and liver carcinogens when administered in multiple i.p. doses to preweanling mice. 1,6-Dinitropyrene has been shown to be a strong hepatocarcinogen but a weak lung carcinogen in this same bioassay. We have examined carcinogen-DNA adduct profiles in the target tissues of preweanling male CD-1 mice following administration of single or multiple doses of these compounds. Depending on the tissue and the dosing schedule, the total level of DNA modification in animals dosed with [3H]NC was 2- to 9-fold higher than in animals dosed with [3H]AC. Regardless of the dosing schedule, DNA isolated from the lungs and livers of both [3H]NC- and [3H]AC-treated preweanling male mice contained a single major and chromatographically identical adduct. This major adduct, which accounted for as much as 90% of the total carcinogen-DNA adducts in enzymatic hydrolysates from treated animals, was chromatographically distinct from the major C8-purine-substituted adducts formed from the reaction of N-hydroxy-AC with calf thymus DNA. In contrast to the results obtained with NC and AC, the major carcinogen-DNA adduct formed in the livers of mice treated with [3H]-1,6-dinitropyrene was found to cochromatograph with 1-N-(deoxyguanosin-8-yl)amino-6-nitropyrene, a product derived from N-hydroxy-1-amino-6-nitropyrene. Since NC and its nitro-reduced derivative, AC, yielded an identical carcinogen-DNA adduct in vivo and this adduct was not derived from N-hydroxy-AC, we conclude that the metabolic activation of NC in the neonatal mouse must involve some previously undescribed combination of ring-oxidation and nitro-reduction pathways. This activation pathway could be an important factor in determining the potency of NC and AC as carcinogens in this bioassay system.
JF  - Cancer research
AU  - Delclos, K B
AU  - Walker, R P
AU  - Dooley, K L
AU  - Fu, P P
AU  - Kadlubar, F F
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1987/12/01/
PY  - 1987
DA  - 1987 Dec 01
SP  - 6272
EP  - 6277
VL  - 47
IS  - 23
SN  - 0008-5472, 0008-5472
KW  - Chrysenes
KW  - 0
KW  - Phenanthrenes
KW  - Pyrenes
KW  - 1,6-dinitropyrene
KW  - 66Q2ZUF83N
KW  - 6-nitrochrysene
KW  - 82ZK83O33Y
KW  - DNA
KW  - 9007-49-2
KW  - 6-chrysenamine
KW  - I56L81BL2L
KW  - Index Medicus
KW  - Animals, Suckling
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Mice
KW  - Male
KW  - Chromatography, High Pressure Liquid
KW  - Phenanthrenes -- metabolism
KW  - DNA -- metabolism
KW  - Pyrenes -- metabolism
KW  - Liver -- metabolism
KW  - Lung -- metabolism
KW  - Chrysenes -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-05
N1  - Date created - 1988-01-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Fatal occupational injuries of women, Texas 1975-84.
AN  - 81095938; 3674251
AB  - A review of Texas death certificates for 1975-84 identified 348 cases of fatal occupational injuries of civilian females. Homicides accounted for 53 per cent and motor vehicle-related injuries accounted for 26 per cent of the deaths. Injuries from firearms caused 70 per cent of the homicides. One hundred thirty-three deaths occurred to women employed in the retail trade industry; of these, 77 per cent resulted from homicide. Women workers in gasoline service stations, food-bakery-and-dairy stores, and eating-and-drinking places had especially high risks of homicide. Texas female heavy-truck drivers had the highest fatal-injury rate, with motor-vehicle-related injuries causing 89 per cent of their deaths. These results indicate that effective strategies to prevent fatal occupational injuries of Texas women will need to address the problems of workplace violence and the hazards posed by motor vehicles.
JF  - American journal of public health
AU  - Davis, H
AU  - Honchar, P A
AU  - Suarez, L
AD  - Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, MD 20857.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 1524
EP  - 1527
VL  - 77
IS  - 12
SN  - 0090-0036, 0090-0036
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Fires
KW  - Age Factors
KW  - Humans
KW  - Aged
KW  - Texas
KW  - Accidental Falls
KW  - Homicide
KW  - Epidemiology
KW  - Aged, 80 and over
KW  - Risk Factors
KW  - Adult
KW  - Death Certificates
KW  - Middle Aged
KW  - Accidents, Traffic
KW  - Occupations
KW  - Adolescent
KW  - Male
KW  - Wounds and Injuries -- mortality
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-17
N1  - Date created - 1987-12-17
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
J Public Health Policy. 1980 Sep;1(3):224-9 [7251838]
JAMA. 1982 Aug 13;248(6):692-7 [7097919]
Am J Public Health. 1987 Oct;77(10):1290-3 [3631362]
Am J Public Health. 1985 Jun;75(6):587-8 [4003620]
Am J Public Health. 1986 Jun;76(6):635-7 [3706589]
J Occup Med. 1984 Apr;26(4):288-96 [6716197]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Monoclonal antibody for the detection of Clostridium botulinum type A toxin.
AN  - 78034564; 3453424
AB  - Hybridomas producing monoclonal antibodies against type A Hall strain Clostridium botulinum toxin were generated by fusing mouse myeloma cell line P3-X63-Ag8.653 with spleen cells of Balb/c mice immunized with C. botulinum type A toxoid. The monoclonal antibody from one hybridoma, identified as No. 424, was selected from 61 others for its high antibody titre. This monoclonal antibody was used in a double-sandwich enzyme-linked immunosorbent assay (ELISA) system to detect type A toxin in culture fluids and in foods. The monoclonal antibody did not react with either C. botulinum toxin types B, C, D, E and F or with other clostridial species tested. This particular monoclonal antibody (No. 424) did not neutralize type A toxin in the mouse bioassay procedure but detected approximately 10 mouse lethal doses of type A toxin/ml culture fluid. Monoclonal antibody and rabbit antitoxin to type A C. botulinum toxin were useful in a double-sandwich ELISA for the rapid and specific detection of type A toxic fluids in culture and in food samples.
JF  - Molecular and cellular probes
AU  - Ferreira, J L
AU  - Hamdy, M K
AU  - Herd, Z L
AU  - McCay, S G
AU  - Zapatka, F A
AD  - FDA, Atlanta, Georgia 30309.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 337
EP  - 345
VL  - 1
IS  - 4
SN  - 0890-8508, 0890-8508
KW  - Antibodies, Monoclonal
KW  - 0
KW  - Botulinum Antitoxin
KW  - Botulinum Toxins
KW  - EC 3.4.24.69
KW  - Index Medicus
KW  - Animals
KW  - Hybridomas
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Cell Line
KW  - Botulinum Toxins -- analysis
KW  - Enzyme-Linked Immunosorbent Assay
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-22
N1  - Date created - 1988-08-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Assessment of cadmium, lead and vanadium status of large animals as related to the human food chain.
AN  - 77996794; 3327851
AB  - Cadmium (Cd) and lead (Pb) are of established toxicological significance for humans, and it is important that intakes from foods not cause excessive exposure. Both elements concentrate to high levels in liver and kidneys of large, domestic food animals (cattle, sheep and swine), and Pb also concentrates in bone, which is sometimes used in the form of bone meal as a dietary supplement. Milk is a significant source of Cd and Pb for infants and toddlers. Levels of these elements in domestic food animal tissues and milk are presently within acceptable ranges for human consumption. Vanadium (V) sources to animals may increase and create potential human food problems; however, at the present time meats and milk are safe to consume with respect to this element.
JF  - Journal of animal science
AU  - Fox, M R
AD  - Div. of Nutr., Food and Drug Administration, Washington, DC 20204.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 1744
EP  - 1752
VL  - 65
IS  - 6
SN  - 0021-8812, 0021-8812
KW  - Cadmium
KW  - 00BH33GNGH
KW  - Vanadium
KW  - 00J9J9XKDE
KW  - Lead
KW  - 2P299V784P
KW  - Index Medicus
KW  - Nutritional Status
KW  - Animals
KW  - Humans
KW  - Food
KW  - Cadmium -- metabolism
KW  - Vanadium -- metabolism
KW  - Lead -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-26
N1  - Date created - 1988-04-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Amelioration of chronic anthracycline cardiotoxicity by ICRF-187 and other compounds.
AN  - 77960054; 3125968
JF  - Cancer treatment reviews
AU  - Herman, E H
AU  - Ferrans, V J
AD  - Division of Drug Biology, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 225
EP  - 229
VL  - 14
IS  - 3-4
SN  - 0305-7372, 0305-7372
KW  - Piperazines
KW  - 0
KW  - Vitamin E
KW  - 1406-18-4
KW  - Razoxane
KW  - 5AR83PR647
KW  - Doxorubicin
KW  - 80168379AG
KW  - Acetylcysteine
KW  - WYQ7N0BPYC
KW  - Index Medicus
KW  - Swine
KW  - Animals
KW  - Acetylcysteine -- therapeutic use
KW  - Dogs
KW  - Vitamin E -- therapeutic use
KW  - Razoxane -- therapeutic use
KW  - Piperazines -- therapeutic use
KW  - Heart Diseases -- chemically induced
KW  - Doxorubicin -- toxicity
KW  - Heart Diseases -- prevention & control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-18
N1  - Date created - 1988-04-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The role of metabolism in the testing of developmental toxicants.
AN  - 77959406; 3326058
AB  - The delivery of potential developmental toxicants to the conceptus is dependent on several metabolic and pharmacokinetic factors. Within the maternal-embryo/fetal unit, maternal, placental, and embryo/fetal factors must be considered. These factors include blood flow, permeability, biotransformation, and elimination. Pharmacokinetic models based on data gathered from appropriate in vivo and in vitro studies may be used to describe the effect of these factors on toxicant delivery to the conceptus. Several known human developmental toxicants are discussed in terms of the metabolic and pharmacokinetic factors controlling their delivery to the conceptus. Metabolic events, including activation and/or detoxification, have been reported for the majority of the toxicants examined. Thus it would appear that the role of metabolism should be considered during the testing of potential developmental toxicants.
JF  - Regulatory toxicology and pharmacology : RTP
AU  - Slikker, W
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 390
EP  - 413
VL  - 7
IS  - 4
SN  - 0273-2300, 0273-2300
KW  - Teratogens
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Humans
KW  - Teratogens -- metabolism
KW  - Teratogens -- pharmacokinetics
KW  - Teratogens -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-07
N1  - Date created - 1988-04-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - A novel device for the automated administration of test compounds to laboratory animals.
AN  - 77942410; 3437755
AB  - A prototype instrument is described that permits efficient administration of test compounds to laboratory animals by intubation. The system integrates a balance, a computer and a volumetric dispenser. Complete animal identification, weight and dose records are kept and may be interfaced with mainframe computers. A range of doses may be delivered from a single stock solution. No carryover is evident between doses. The system is accurate, precise and rugged. The system is cost effective relative to current manual gavage techniques and offers added safety for investigators handling toxic materials.
JF  - Laboratory animal science
AU  - Crowell, J A
AU  - Parker, R M
AU  - Bucci, T J
AU  - Dacre, J C
AD  - Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 782
EP  - 785
VL  - 37
IS  - 6
SN  - 0023-6764, 0023-6764
KW  - Pharmaceutical Preparations
KW  - 0
KW  - Index Medicus
KW  - Body Weight
KW  - Administration, Oral
KW  - Animals
KW  - Drug Administration Schedule
KW  - Microcomputers
KW  - Pharmaceutical Preparations -- administration & dosage
KW  - Toxicology -- instrumentation
KW  - Animals, Laboratory
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-01
N1  - Date created - 1988-04-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The use of new field methods of semen analysis in the study of occupational hazards to reproduction: the example of ethylene dibromide.
AN  - 77912560; 3323429
AB  - Increasing attention has been paid to the use of semen analysis as an indicator of exposure to potential mutagenic and reproductive hazards. In the infertility clinic setting, semen evaluations include the measurement of sperm concentration, volume, pH, motility, velocity and morphology, the analysis of seminal plasma to evaluate accessory sex gland function and, in some cases, the in vitro evaluation of fertilization capacity and sperm-cervical mucus interaction (Ann Intern Med 1985;103:906-919). To date, however, the study of semen characteristics of occupationally exposed populations has been confined principally to the measurement of sperm concentration and sperm morphology. This has been largely due to the unavailability of portable equipment suitable for the measurement of other semen characteristics and the difficulty of obtaining fresh semen samples in the field setting. National Institute for Occupational Safety and Health researchers have developed mobile laboratory facilities which enable us to evaluate fresh samples, in the field, for semen characteristics in addition to concentration and morphology. This paper describes the application of these methods using the example of our recent cross-sectional study of workers occupationally exposed to ethylene dibromide in the papaya fumigation industry. We discuss our findings in the context of the usefulness of semen analysis as an indicator of occupational hazards to male reproduction.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Schrader, S M
AU  - Ratcliffe, J M
AU  - Turner, T W
AU  - Hornung, R W
AD  - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 963
EP  - 966
VL  - 29
IS  - 12
SN  - 0096-1736, 0096-1736
KW  - Hydrocarbons, Brominated
KW  - 0
KW  - Ethylene Dibromide
KW  - 1N41638RNO
KW  - Index Medicus
KW  - Sperm Count -- drug effects
KW  - Humans
KW  - Environmental Exposure
KW  - Sperm Motility -- drug effects
KW  - Male
KW  - Ethylene Dibromide -- poisoning
KW  - Hydrocarbons, Brominated -- poisoning
KW  - Fumigation
KW  - Semen -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-11
N1  - Date created - 1988-03-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The in vitro embryotoxicity of 5-fluorouracil in rat embryos.
AN  - 77879852; 3424225
AB  - The fluorinated pyrimidine 5-fluorouracil (5-FU) is an effective chemotherapeutic agent that is teratogenic in a number of species. The mechanism for the embryopathic effect of the drug is unknown. We examined the effects of this compound on gestation day 10.5 rat embryos cultured for 48 hours in a rodent whole embryo culture system. Embryos were exposed for 1-4 hours to various doses of 5-FU. Embryolethality was minimal in all treatment groups. The malformation frequency increased with higher doses; within a dose, the malformation frequency increased with longer exposure to the drug. The tail and hindlimb bud were the most commonly affected structures in vitro; tail and leg defects are produced in several species by exposure to the drug in vivo. The embryopathic drug concentration in the culture media (2-8 micrograms/ml) is similar to the plasma level of 2-17 micrograms/ml, which is associated with embryopathy in vivo. Results from this study suggest that the whole embryo culture system is an appropriate model for developmental toxicity studies of 5-FU.
JF  - Teratology
AU  - Grafton, T F
AU  - Bazare, J J
AU  - Hansen, D K
AU  - Sheehan, D M
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 371
EP  - 377
VL  - 36
IS  - 3
SN  - 0040-3709, 0040-3709
KW  - Teratogens
KW  - 0
KW  - Fluorouracil
KW  - U3P01618RT
KW  - Index Medicus
KW  - Rats
KW  - Abnormalities, Drug-Induced -- pathology
KW  - Animals
KW  - Organ Culture Techniques
KW  - Female
KW  - Embryonic and Fetal Development -- drug effects
KW  - Fluorouracil -- toxicity
KW  - Embryo, Mammalian -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-20
N1  - Date created - 1988-02-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The role of specific IgE and beta-propiolactone in reactions resulting from booster doses of human diploid cell rabies vaccine.
AN  - 77874680; 3693763
AB  - Reactions after booster injections of human diploid cell rabies vaccine (HDCV) were investigated to determine the possibility of IgE-type antibody involvement. Although normal manufacture of HDCV involves the inactivation of the virus with beta-propiolactone (BPL), the effect of BPL on nonviral vaccine components, such as host cell components or stabilizing proteins, may be typical of the haptenic action of small molecular weight chemicals. Specific IgE to commercial HDCV preparations, BPL-treated preparations of noninfected host MRC5 cell sonicate (BPL-MRC5), and a human albumin (HA) (BPL-HA) used as a stabilizing agent were detected in sera from five individuals who reported reactions after booster doses of HDCV. However, these patients had no detectable IgE to normal HA. Sera from nonvaccinated individuals, vaccinated individuals who reported no reaction after HDCV booster, and pollen-allergic individuals had no detectable IgE to HDCV, BPL-MRC5, or BPL-HA. Changes in the ratios of pre- to postbooster serum levels of specific IgE to HDCV and BPL-HA were significantly different in a group of 19 individuals who reported reactions to HDCV boosters; these changes in pre- to postbooster IgE levels in nonreactive vaccinees were not significant. Prebooster serum IgE RAST ratios to HDCV or BPL-HA were not predictive of potential reactions to HDCV. A number of experimental BPL-HA reaction mixtures were assayed to examine the effect of variable concentrations of BPL to HA. Increasing relative molar concentrations of BPL to HA resulted in increased electrophoretic mobility, whereas the highest relative specific IgE binding was detected in BPL-HA molar reaction mixtures of approximately 12.5:1.(ABSTRACT TRUNCATED AT 250 WORDS)
JF  - The Journal of allergy and clinical immunology
AU  - Anderson, M C
AU  - Baer, H
AU  - Frazier, D J
AU  - Quinnan, G V
AD  - Office of Biologics Research and Review, Food and Drug Administration, Bethesda, MD 20892.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 861
EP  - 868
VL  - 80
IS  - 6
SN  - 0091-6749, 0091-6749
KW  - Lactones
KW  - 0
KW  - Rabies Vaccines
KW  - Serum Albumin
KW  - Immunoglobulin E
KW  - 37341-29-0
KW  - Propiolactone
KW  - 6RC3ZT4HB0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Radioallergosorbent Test
KW  - Humans
KW  - Serum Albumin -- immunology
KW  - Cell Transformation, Viral -- drug effects
KW  - Cell Line
KW  - Lactones -- adverse effects
KW  - Rabies Vaccines -- adverse effects
KW  - Antibody Specificity
KW  - Immunoglobulin E -- physiology
KW  - Propiolactone -- adverse effects
KW  - Rabies Vaccines -- immunology
KW  - Propiolactone -- pharmacology
KW  - Propiolactone -- immunology
KW  - Immunization, Secondary -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-02
N1  - Date created - 1988-02-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The biological exposure index: its use in assessing chemical exposures in the workplace.
AN  - 77847720; 3686532
AB  - Human exposure to chemicals in the workplace has traditionally been assessed by determining the concentration of an airborne chemical in the workroom air. More recently, biological monitoring has been used to assess worker uptake of chemicals by all routes of exposure. Both approaches for the assessment of exposure and uptake are complementary. This relationship is examined, along with the advantages and limitations of using biological monitoring. The concept of the biological exposure index (BEI), developed by the American Conference of Governmental Industrial Hygienists (ACGIH), and information on the intended use and interpretation of BEIs are described. Examples are presented on the use of biological monitoring in NIOSH Health Hazard Evaluations (e.g., carboxyhemoglobin in blood to assess exposure to carbon monoxide, urinary metabolites of trichloroethylene to assess exposure to trichloroethanol, and 2-ethoxyacetic acid in urine to assess exposure to 2-ethoxyethanol). The progress of current research studies on the biological monitoring of volunteers exposed to paint spray solvents is presented, along with speculation on the future directions of biological monitoring research.
JF  - Toxicology
AU  - Lowry, L K
AD  - Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1987/12/01/
PY  - 1987
DA  - 1987 Dec 01
SP  - 55
EP  - 69
VL  - 47
IS  - 1-2
SN  - 0300-483X, 0300-483X
KW  - Acetates
KW  - 0
KW  - Butanones
KW  - Ethylene Glycols
KW  - Trichloroethylene
KW  - 290YE8AR51
KW  - ethoxyacetic acid
KW  - 467VW095BX
KW  - Trichloroacetic Acid
KW  - 5V2JDO056X
KW  - methylethyl ketone
KW  - 6PT9KLV9IO
KW  - Ethylene Chlorohydrin
KW  - 753N66IHAN
KW  - 2,2,2-trichloroethanol
KW  - AW835AJ62N
KW  - 2-ethoxyethanol
KW  - IDK7C2HS09
KW  - Index Medicus
KW  - United States
KW  - Trichloroethylene -- adverse effects
KW  - Ethylene Chlorohydrin -- urine
KW  - Humans
KW  - Acetates -- urine
KW  - Butanones -- adverse effects
KW  - Paint -- adverse effects
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Ethylene Glycols -- pharmacokinetics
KW  - Environmental Monitoring
KW  - Trichloroacetic Acid -- urine
KW  - Trichloroethylene -- pharmacokinetics
KW  - Maximum Allowable Concentration
KW  - Ethylene Glycols -- adverse effects
KW  - Ethylene Chlorohydrin -- analogs & derivatives
KW  - Butanones -- pharmacokinetics
KW  - Industry
KW  - Environmental Exposure
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=The+biological+exposure+index%3A+its+use+in+assessing+chemical+exposures+in+the+workplace.&rft.au=Lowry%2C+L+K&rft.aulast=Lowry&rft.aufirst=L&rft.date=1987-12-01&rft.volume=47&rft.issue=1-2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-12
N1  - Date created - 1988-01-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Clinical evaluation of medicines used by the elderly.
AN  - 77846327; 3690944
JF  - Clinical pharmacology and therapeutics
AU  - Young, F E
AD  - Food and Drug Administration, Rockville, MD 20857.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 666
EP  - 669
VL  - 42
IS  - 6
SN  - 0009-9236, 0009-9236
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Drug Industry
KW  - Drug Interactions
KW  - Humans
KW  - Clinical Trials as Topic -- standards
KW  - Aged
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-09
N1  - Date created - 1988-02-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Determinants of chronic bronchitis and lung dysfunction in Western Australian gold miners.
AN  - 77844511; 3689716
AB  - The relation of chronic bronchitis and respiratory dysfunction to age, tobacco smoking, and occupational exposure to surface and underground mining operations were examined in a cross sectional survey of 1363 men employed in the Kalgoorlie mining industry in 1985. Overall, the prevalence of chronic bronchitis was 14%. Eleven per cent of the workers had obstructive lung disorder (FEV1/FVC less than 0.70) and 9% had restrictive lung disorder (FVC less than 0.80 of predicted for height and age). There was little change in the prevalence of chronic bronchitis from that observed in a survey of the same industry in 1961-2. Only 1% of the workers in 1985 had radiographic signs of silicosis compared with 22% in 1961-2. Age, smoking, and underground mining experience all exerted strong effects on the development of chronic bronchitis with or without associated respiratory function abnormalities. After control of confounding by age and smoking, it was estimated that compared with a lifetime non-miner, the odds ratio (OR) of chronic bronchitis was 1.8 (95% confidence interval, 1.0-3.3) for one to nine years underground mining gold, 2.5 (1.2-5.2) for 10-19 years, and 5.1 (2.4-10.9) for 20 or more years. Underground mining of minerals other than gold was also associated with chronic bronchitis (OR = 5.1; 95% CI, 1.1-25.0) whereas exclusive surface mining had only a small empirical effect (OR = 1.3; 95% CI, 0.6-2.5). It is estimated that the proportion of cases of chronic bronchitis in working underground miners due to occupational factors is 50%. The results support the existence of an industrial cause of chronic bronchitis, although caution must be exercised in generalising the results to miners with progressive and sever respiratory impairment.
JF  - British journal of industrial medicine
AU  - Holman, C D
AU  - Psaila-Savona, P
AU  - Roberts, M
AU  - McNulty, J C
AD  - Public Health Service, Health Department of Western Australia, Perth.
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 810
EP  - 818
VL  - 44
IS  - 12
SN  - 0007-1072, 0007-1072
KW  - Dust
KW  - 0
KW  - Gold
KW  - 7440-57-5
KW  - Index Medicus
KW  - Lung Diseases, Obstructive -- etiology
KW  - Age Factors
KW  - Humans
KW  - Western Australia
KW  - Adult
KW  - Smoking -- adverse effects
KW  - Middle Aged
KW  - Chronic Disease
KW  - Child
KW  - Adolescent
KW  - Male
KW  - Bronchitis -- etiology
KW  - Occupational Diseases -- etiology
KW  - Occupational Diseases -- physiopathology
KW  - Mining
KW  - Lung -- physiopathology
KW  - Gold -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-24
N1  - Date created - 1988-02-24
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Br J Ind Med. 1967 Jan;24(1):1-12 [6017135]
Proc R Soc Med. 1970 Sep;63(9):857-64 [5477056]
Br J Ind Med. 1973 Jul;30(3):217-26 [4723786]
Am Rev Respir Dis. 1973 Oct;108(4):886-93 [4741884]
Am J Epidemiol. 1974 Jun;99(6):385-8 [4841816]
Br J Ind Med. 1981 Feb;38(1):1-13 [7470398]
Thorax. 1976 Oct;31(5):527-33 [996815]
Am Rev Respir Dis. 1978 Mar;117(3):429-35 [629477]
Br J Ind Med. 1978 Nov;35(4):285-91 [367424]
JAMA. 1980 Jun 20;243(23):2401-4 [6445430]
Am J Epidemiol. 1976 Feb;103(2):226-35 [1251836]
N1  - Last updated - 2017-01-17
ER  - 



TY  - GEN
T1  - Childhood Lead Poisoning. Current Perspectives. Proceedings of the National Conference (Indianapolis, Indiana, December 1-3, 1987).
AN  - 62949715; ED331780
AB  - Since childhood lead poisoning first gained recognition as an important public health problem, the concept of lead poisoning has been examined and revised repeatedly. This national conference was convened to review and examine the current state of the problem, prevention activities, and recent studies on the toxic effects of lead at very low levels. Papers presented at the conference focused on the following topics: (1) changing sources of lead poisoning; (2) national perspectives; (3) overview of low-lead toxicity; (4) low-level exposure and children's development; (5) U.S. Department of Housing and Urban Development regulations; (6) the Environmental Protection Agency's perspective on lead in water, gasoline, and soil; (7) regional collaboration; (8) laboratory issues; (9) environmental issues; (10) legal issues; (11) lead used as treatment in folk medicine and other nonpaint sources of lead; and (12) future directions. (JD)
Y1  - 1987/12//
PY  - 1987
DA  - December 1987
SP  - 147
KW  - ERIC, Resources in Education (RIE)
KW  - Health Services
KW  - Prevention
KW  - Public Health
KW  - Government Role
KW  - National Programs
KW  - Lead Poisoning
KW  - Federal Regulation
KW  - Compliance (Legal)
KW  - Child Welfare
KW  - Screening Tests
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62949715?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Phytophotodermatitis from celery among grocery store workers.
AN  - 81101595; 2960270
AB  - We detected 19 cases of phytophotodermatitis during a cross-sectional epidemiological investigation of two Oregon grocery stores that were part of the same supermarket chain. Outdoor sunlight exposure during the workshift and tanning salon use were identified as risk factors; the most severe cutaneous reactions tended to occur among tanning salon users. Although both stores carried the same brands and varieties of produce, all 19 cases occurred among employees of one store, which had held a celery sale coincident with the outbreak, resulting in a quadrupling of the usual volume of celery sold. We found elevated psoralen levels in two of three celery samples obtained from the affected store; cutaneous provocation tests with trimmed surfaces of these celery samples produced phototoxic reactions. Preliminary experiments with one brand of celery have demonstrated psoralen levels as high as 25 micrograms/cm2 of trimmed surface. These observations suggest that clinical phytophotodermatitis among grocery store workers may be caused by healthy celery and results from a complex interaction of exposure variables, including ultraviolet radiation from tanning salon use, frequency of handling celery, celery brand, and sporadic elevation of psoralen content from environmental stresses.
JF  - Archives of dermatology
AU  - Seligman, P J
AU  - Mathias, C G
AU  - O'Malley, M A
AU  - Beier, R C
AU  - Fehrs, L J
AU  - Serrill, W S
AU  - Halperin, W E
AD  - Division of Surveillance, Hazards Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 1478
EP  - 1482
VL  - 123
IS  - 11
SN  - 0003-987X, 0003-987X
KW  - Furocoumarins
KW  - 0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Oregon
KW  - Cross-Sectional Studies
KW  - Risk Factors
KW  - Humans
KW  - Food Handling
KW  - Sunlight
KW  - Furocoumarins -- analysis
KW  - Vegetables -- adverse effects
KW  - Photosensitivity Disorders -- etiology
KW  - Dermatitis, Occupational -- etiology
KW  - Vegetables -- analysis
KW  - Photosensitivity Disorders -- epidemiology
KW  - Dermatitis, Occupational -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-27
N1  - Date created - 1987-11-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The turnover of radiolabeled nuclear proteins in rats exposed to environmental and chemical stress.
AN  - 81090303; 3672552
AB  - Exposure to a 12 h light/12 h dark (L/D) cycle for 1 month, followed by reversal to a 12 h D/12 h L (D/L) cycle stimulated within 18 h the incorporation of [3H]leucine and [32P]orthophosphoric acid into new proteins (130-25 kDa) in the G0 phase of the cell cycle of the non-regenerating and regenerating rat liver as observed in two-dimensional gel autoradiograms. Six additional proteins from the rat submaxillary gland (130-20 kDa) revealed labeling with 32P within 3 h following combined administration of isoproterenol and sodium arsenite. Labeling disappeared within 7 days for all stressed proteins.
JF  - Toxicology letters
AU  - Pipkin, J L
AU  - Anson, J F
AU  - Hinson, W G
AU  - Duffy, P H
AU  - Burns, E R
AU  - Casciano, D A
AD  - Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 15
EP  - 26
VL  - 39
IS  - 1
SN  - 0378-4274, 0378-4274
KW  - Arsenites
KW  - 0
KW  - Nuclear Proteins
KW  - Phosphates
KW  - Phosphorus Radioisotopes
KW  - Sodium Compounds
KW  - Tritium
KW  - 10028-17-8
KW  - sodium arsenite
KW  - 48OVY2OC72
KW  - Leucine
KW  - GMW67QNF9C
KW  - Isoproterenol
KW  - L628TT009W
KW  - Arsenic
KW  - N712M78A8G
KW  - Index Medicus
KW  - Rats
KW  - Phosphates -- metabolism
KW  - Animals
KW  - Kinetics
KW  - Leucine -- metabolism
KW  - Male
KW  - Cell Cycle -- drug effects
KW  - Liver -- pathology
KW  - Arsenic -- toxicity
KW  - Submandibular Gland -- pathology
KW  - Submandibular Gland -- metabolism
KW  - Liver -- drug effects
KW  - Submandibular Gland -- drug effects
KW  - Liver -- metabolism
KW  - Nuclear Proteins -- metabolism
KW  - Liver Regeneration
KW  - Isoproterenol -- toxicity
KW  - Stress, Physiological -- physiopathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-16
N1  - Date created - 1987-12-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Cardiorespiratory arrests temporally associated with injection of intravenous ampicillin in infants: investigation of a suspected cluster.
AN  - 81086561; 3670961
AB  - In August 1985, the FDA received reports of infants who had cardiorespiratory arrests associated with a widely used IV ampicillin product. The events occurred during July and August 1985 in three hospitals located in different parts of the United States. To assess the possibility of a product defect, an epidemiologic investigation was undertaken to determine whether the suspect ampicillin product was associated with an excess number of serious adverse events among infants in 1985. Because complete ampicillin brand information was unavailable for two of the three hospitals, a nonconcurrent cohort study was conducted to test whether the proportion of serious adverse events among infants who were hospitalized between July 1 and Aug 23, 1985, and exposed to any brand of IV ampicillin was different from the proportion of serious adverse events among infants who were hospitalized during the same time in 1984 and exposed to IV ampicillin. No statistically significant difference was found. A follow-up incidence density study at the hospital for which complete ampicillin brand information was known determined that the suspect ampicillin product was not associated with an increased number of serious adverse events in 1985. No common lots of the suspect ampicillin product were identified at the three hospitals. It was concluded that the suspect ampicillin product was not the cause of the cluster of serious adverse events observed among infants in July and August 1985 based on epidemiologic findings.
JF  - Pediatrics
AU  - Nelson, W L
AU  - Wise, R
AU  - Kuritsky, J N
AD  - Center for Drugs and Biologics, Food and Drug Administration, Rockville, Maryland 20857.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 613
EP  - 617
VL  - 80
IS  - 5
SN  - 0031-4005, 0031-4005
KW  - Gentamicins
KW  - 0
KW  - Ampicillin
KW  - 7C782967RD
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Infant
KW  - Injections, Intravenous
KW  - Humans
KW  - Gentamicins -- administration & dosage
KW  - Infant Mortality
KW  - Child
KW  - Space-Time Clustering
KW  - Cause of Death
KW  - Evaluation Studies as Topic
KW  - Heart Arrest -- chemically induced
KW  - Product Surveillance, Postmarketing
KW  - Ampicillin -- adverse effects
KW  - Ampicillin -- administration & dosage
KW  - Heart Arrest -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-11
N1  - Date created - 1987-12-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene.
AN  - 81065962; 3664962
AB  - Since 6-nitrochrysene and 6-aminochrysene have shown activity in carcinogenicity bioassays, we have begun an investigation of their metabolic activation pathways and the nature of the carcinogen-DNA adducts that may be formed. N-Hydroxy-6-aminochrysene (N-hydroxy-AC), a candidate proximate or ultimate carcinogen and the highest polycyclic N-hydroxy arylamine homolog studied thus far, was prepared by direct chemical synthesis and characterized by 1H-n.m.r. spectroscopy. Its rate and extent of reaction with DNA in vitro was 20-30 nmol bound/mg DNA/30 min, which is 2-10 times greater than has been reported for several other carcinogenic N-hydroxy arylamines. Three major aminochrysene-nucleoside adducts were detected in enzymatic hydrolysates of this N-hydroxy-AC-modified DNA, and these were isolated and identified by mass and 1H-n.m.r. spectroscopy as N-(deoxyinosin-8-yl)-6-aminochrysene, 5-(deoxyguanosin-N2-yl)-6-aminochrysene, and N-(deoxyguanosin-8-yl)-6-aminochrysene. These adducts accounted for 32%, 28%, and 22% respectively, of the total DNA adducts formed. We hypothesize that the deoxyinosine adduct is derived from spontaneous oxidation of the corresponding deoxyadenosine adduct prior to or during DNA isolation and adduct preparation. DNA isolated from Sprague-Dawley rat hepatocytes which had been treated with [3H]6-aminochrysene or [3H]6-nitrochrysene contained up to 12 pmol adducts/mg DNA (4 adducts per 10(6) nucleotides). High performance liquid chromatography (h.p.l.c.) analyses of enzymatic hydrolysates of this DNA indicated that the major products formed cochromatographed with the C8-deoxyinosine and C8-deoxyguanosine adducts. N-(Deoxyinosin-8-yl)-6-aminochrysene and N-(deoxyguanosin-8-yl)-6-aminochrysene accounted for 45% and 30% respectively, of the total DNA adducts formed in these cells. The preferential modification of deoxyadenosine by N-hydroxy-6-aminochrysene and the apparent facile oxidation of this adduct to a deoxyinosine derivative is thus far unique among the reactions of N-hydroxyarylamines with DNA and would not be predicted on the basis of reactivity alone.
JF  - Carcinogenesis
AU  - Delclos, K B
AU  - Miller, D W
AU  - Lay, J O
AU  - Casciano, D A
AU  - Walker, R P
AU  - Fu, P P
AU  - Kadlubar, F F
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 1703
EP  - 1709
VL  - 8
IS  - 11
SN  - 0143-3334, 0143-3334
KW  - Carcinogens
KW  - 0
KW  - Chrysenes
KW  - Phenanthrenes
KW  - Tritium
KW  - 10028-17-8
KW  - N-hydroxy-6-aminochrysene
KW  - 114451-10-4
KW  - Inosine
KW  - 5A614L51CT
KW  - 6-nitrochrysene
KW  - 82ZK83O33Y
KW  - DNA
KW  - 9007-49-2
KW  - Deoxyguanosine
KW  - G9481N71RO
KW  - deoxyinosine
KW  - HN0RQ6SBWQ
KW  - 6-chrysenamine
KW  - I56L81BL2L
KW  - Index Medicus
KW  - Rats
KW  - Mass Spectrometry
KW  - Animals
KW  - Biotransformation
KW  - Phenanthrenes -- metabolism
KW  - Deoxyguanosine -- metabolism
KW  - Carcinogens -- metabolism
KW  - Inosine -- metabolism
KW  - Inosine -- analogs & derivatives
KW  - DNA -- metabolism
KW  - Liver -- metabolism
KW  - Chrysenes -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-07
N1  - Date created - 1987-12-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Severe dermatologic reactions reported after treatment with tocainide.
AN  - 81051634; 2959186
JF  - Annals of internal medicine
AU  - Arrowsmith, J B
AU  - Creamer, J I
AU  - Bosco, L
AD  - U.S. Food and Drug Administration, Rockville, Maryland.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 693
EP  - 696
VL  - 107
IS  - 5
SN  - 0003-4819, 0003-4819
KW  - Anti-Arrhythmia Agents
KW  - 0
KW  - Tocainide
KW  - 27DXO59SAN
KW  - Lidocaine
KW  - 98PI200987
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Aged
KW  - Erythema Multiforme -- chemically induced
KW  - Stomatitis -- chemically induced
KW  - Dermatitis, Exfoliative -- chemically induced
KW  - Aged, 80 and over
KW  - Stevens-Johnson Syndrome -- chemically induced
KW  - Adult
KW  - Product Surveillance, Postmarketing
KW  - Middle Aged
KW  - Female
KW  - Male
KW  - Drug Eruptions -- etiology
KW  - Lidocaine -- adverse effects
KW  - Lidocaine -- analogs & derivatives
KW  - Anti-Arrhythmia Agents -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-20
N1  - Date created - 1987-11-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Mortality of workers exposed to polychlorinated biphenyls--an update.
AN  - 77950568; 3125795
AB  - A retrospective cohort mortality study of workers exposed to polychlorinated biphenyls (PCBs) in two plants manufacturing electrical capacitors was reported in 1981. The study was conducted primarily to examine the risk of cancer mortality associated with exposure to PCBs. Based on animal data, liver cancer was the disease of most interest. Due to the small number of deaths and a relatively short observation period, the study was considered inconclusive. This study has been updated by adding 7 yr of observation. The number of deaths in the study cohort has increased from 163 to 295. Mortality from all causes was found to be lower than expected (295 observed vs. 318 expected deaths) as well as mortality from all cancers (62 observed vs. 80 expected deaths). A statistically significant excess in deaths was observed in the disease category that includes cancer of the liver (primary and unspecified), gall bladder, and biliary tract (5 observed vs. 1.9 expected; p less than .05). Most of this excess was observed in women employed in one plant. Due to the small number of deaths and the variability of specific cause of death within this category, it remains difficult to interpret these findings in regard to PCB exposure.
JF  - Archives of environmental health
AU  - Brown, D P
AD  - Industrywide Studies Branch, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
PY  - 1987
SP  - 333
EP  - 339
VL  - 42
IS  - 6
SN  - 0003-9896, 0003-9896
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Polychlorinated Biphenyls
KW  - DFC2HB4I0K
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - New York
KW  - Bile Duct Neoplasms -- mortality
KW  - Sex Factors
KW  - Neoplasms -- mortality
KW  - Massachusetts
KW  - Humans
KW  - Liver Neoplasms -- mortality
KW  - Retrospective Studies
KW  - Environmental Exposure
KW  - Gallbladder Neoplasms -- mortality
KW  - Male
KW  - Female
KW  - Mortality
KW  - Air Pollutants, Occupational -- adverse effects
KW  - Polychlorinated Biphenyls -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-01
N1  - Date created - 1988-04-01
N1  - Date revised - 2017-01-14
N1  - Last updated - 2017-01-19
ER  - 



TY  - JOUR
T1  - Rapid fluorogenic enumeration of Escherichia coli in selected, naturally contaminated high moisture foods.
AN  - 77947274; 3325491
AB  - An assay for the enzyme glucuronidase was used to determine the presence of Escherichia coli in selected, naturally contaminated high moisture foods. Raw pork sausage, ground turkey, and ground beef were inoculated into tubes containing the substrate 4-methylumbelliferyl beta-D-glucuronide (MUG) in lauryl tryptose (LT) medium. After incubation at 35 degrees C for 24 h, the inoculated LT-MUG tubes were examined under longwave ultraviolet light for the presence of a fluorogenic glucuronidase end product. A fluorescing tube indicated the presumptive presence of E. coli. The 10 day most probable number method of the AOAC and the LT-MUG procedure gave comparable recoveries of E. coli.
JF  - Journal - Association of Official Analytical Chemists
AU  - Poelma, P L
AU  - Wilson, C R
AU  - Andrews, W H
AD  - Food and Drug Administration, Division of Microbiology, Washington, DC 20204.
PY  - 1987
SP  - 991
EP  - 993
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Index Medicus
KW  - Swine
KW  - Animals
KW  - Cattle
KW  - Fluorescence
KW  - Turkeys
KW  - Meat -- analysis
KW  - Food Microbiology
KW  - Escherichia coli -- isolation & purification
KW  - Food Contamination
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Enumeration of Clostridium perfringens spores in human feces: comparison of four culture media.
AN  - 77945862; 2893783
AB  - Enumeration of Clostridium perfringens spores was compared using 4 culture media. Duplicate 1 g portions of 35 stools (25 from C. perfringens food poisoning outbreaks and 10 from normal stools) were heat treated 20 min at 75 degrees C and tested on tryptose-sulfite-cycloserine (TSC) agar, trypticase-soy-blood (TSB) agar, lactose-sulfite (LS) medium, and iron milk (IM) medium. Dilutions were plated directly onto TSB and TSC, and a 3-tube most probable number determination was made with each specimen in LS and IM incubated at 45 degrees C. TSB was easiest to use and nonhemolytic food poisoning strains were readily differentiated from the normal hemolytic biotype on this medium. Confirmed counts on TSC and TSB were similar for all specimens, but counts of 8 of 25 outbreak specimens were 2-4 log units lower in LS and IM than on plating media; spores in specimens associated with 2 of 5 outbreaks were intolerant of the elevated temperatures. Results showed that elevated temperature MPN methods in LS and IM are inappropriate for the examination of outbreak stools.
JF  - Journal - Association of Official Analytical Chemists
AU  - Harmon, S M
AU  - Kautter, D A
AD  - Food and Drug Administration, Division of Microbiology, Washington, DC 20204.
PY  - 1987
SP  - 994
EP  - 996
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Culture Media
KW  - 0
KW  - Index Medicus
KW  - Spores, Bacterial
KW  - Humans
KW  - Feces -- microbiology
KW  - Clostridium perfringens -- physiology
KW  - Clostridium perfringens -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Expanding and tracking the capabilities of pesticide multiresidue methodology used in the Food and Drug Administration's pesticide monitoring programs.
AN  - 77944945; 3436902
AB  - Foods analyzed for pesticide residues in the monitoring programs of the U.S. Food and Drug Administration (FDA) are most often examined by using one or more of the multiresidue methods developed for this purpose over the years. Because no single method can be used for all potential residues, each commodity is examined by a method or methods which will identify and/or determine the chemicals most likely to have been used. FDA conducts research to develop new multiresidue methods, which are included in monitoring programs as needed to cover additional chemicals. FDA's multiresidue methods have undergone continuous study over a 20 year period to ascertain which compounds can and cannot be recovered by them. FDA continues to perform tests to discover a compound's analytical characteristics. Protocols have been published to direct the testing of additional compounds so that new information can be added to the existing compilations. Methods capable of determining residues of single pesticides are used to analyze selected commodities for residues of high priority that cannot be determined by existing multiresidue methods. Pestrak, a computerized listing of pesticide analytical information, has been developed by FDA to keep track of the capabilities of multiresidue methods and the coverage of residues by the single residue methods used in FDA monitoring.
JF  - Journal - Association of Official Analytical Chemists
AU  - McMahon, B M
AU  - Burke, J A
AD  - Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204.
PY  - 1987
SP  - 1072
EP  - 1081
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Pesticide Residues
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - United States Food and Drug Administration
KW  - Chromatography, Gas
KW  - Food Analysis
KW  - Diet
KW  - Quality Control
KW  - Pesticide Residues -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Recommendations for preparing test samples for AOAC collaborative studies of microbiological procedures for foods.
AN  - 77940012; 3436904
AB  - Preparation of test samples for microbial collaborative studies poses problems not encountered in studies on chemical analytes. For Associate Referees who are considering a collaborative study of a microbiological procedure for food analysis, these problems have not been adequately addressed. Types of contamination (natural or artificial), number of test samples required, analyte selection, proper controls, and container selection are addressed herein. The discussion is a supplement to the guidelines contained in the Handbook for AOAC Members.
JF  - Journal - Association of Official Analytical Chemists
AU  - Andrews, W H
AD  - Food and Drug Administration, Division of Microbiology, Washington, DC 20204.
PY  - 1987
SP  - 931
EP  - 936
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Index Medicus
KW  - Specimen Handling
KW  - Food Contamination
KW  - Salmonella
KW  - Research Design
KW  - Food Microbiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Comparison of diethyl ether and ethyl acetate as extracting agents for recovery of Ascaris spp. and Trichuris spp. eggs.
AN  - 77939959; 3436889
AB  - Ethyl acetate and diethyl ether were compared for their ability to recover Ascaris spp. and Trichuris spp. eggs from seeded milorganite, liquid sludge, and cabbage. Concentrations of 10, 100, and 1000 eggs/10 g test sample were prepared for 20 replicates of each product. The use of diethyl ether yielded fewer eggs/10 g than did ethyl acetate in 5 of 6 sets of data. For Ascaris spp., recovery from cabbage was 10 times higher with ethyl acetate at the higher concentration than with diethyl ether. For Trichuris spp., recovery from liquid sludge was slightly higher with diethyl ether for all egg concentrations. The other results ranged from 0 to 23% difference in recovery for the 2 agents. Depending on the parasites in question and the products to be screened, the substitution of ethyl acetate for diethyl ether may be significant.
JF  - Journal - Association of Official Analytical Chemists
AU  - Rude, R A
AU  - Peeler, J T
AU  - Risty, N G
AD  - Food and Drug Administration, Center for Microbiological Investigations, Minneapolis, MN 55401.
PY  - 1987
SP  - 1000
EP  - 1002
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Acetates
KW  - 0
KW  - Ethyl Ethers
KW  - Indicators and Reagents
KW  - Solvents
KW  - Ether
KW  - 0F5N573A2Y
KW  - ethyl acetate
KW  - 76845O8NMZ
KW  - Index Medicus
KW  - Animals
KW  - Food Contamination -- analysis
KW  - Vegetables -- analysis
KW  - Trichuris -- analysis
KW  - Ovum -- analysis
KW  - Ascaris -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Extraction of light filth from whole leaves of alfalfa, lemon balm, papaya, and spearmint: collaborative study.
AN  - 77939248; 3436916
AB  - Results are reported for a collaborative study to extend AOAC method 44.A06-44.A08 to extraction of light filth from whole leaves of alfalfa, lemon balm, papaya, and spearmint. A 5 g (spearmint) or 10 g (alfalfa, lemon balm, papaya) test portion is defatted with isopropanol in a simple reflux apparatus. Rat hairs, insect fragments, and whole insects are isolated by wet sieving on a No. 230 sieve, a deaerating boil in 40% isopropanol, and flotation with mineral oil-heptane (85 + 15) from Tween 80-Na4EDTA (1 + 1) and 40% isopropanol in a Wildman trap flask. Each product was spiked at a different level. For rat hairs, recoveries averaged 82.2% from alfalfa, 88.9% from lemon balm, 80.6% from papaya, and 79.6% from spearmint. Recoveries of whole or equivalent insects from these products averaged 66.1, 218.8, 69.4, and 85.4%, respectively; recoveries of insect fragments from these products averaged 89.6, 94.4, 94.1, and 88.1%, respectively. The method has been adopted official first action for extraction of light filth from whole leaves of alfalfa, papaya, and spearmint. The extension of the method to lemon balm was not recommended because of interferences by intrinsic whole insects, which were the same species as the spike material.
JF  - Journal - Association of Official Analytical Chemists
AU  - Nakashima, M J
AU  - Glaze, L E
AD  - Food and Drug Administration, Division of Microbiology, Washington, DC 20204.
PY  - 1987
SP  - 997
EP  - 999
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Index Medicus
KW  - Rats
KW  - Hair -- analysis
KW  - Animals
KW  - Insects
KW  - Medicago sativa -- analysis
KW  - Condiments -- analysis
KW  - Fruit -- analysis
KW  - Food Contamination -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Screening cosmetic products for N-nitroso compounds by chemiluminescent determination of nitric oxide.
AN  - 77936954; 3436908
AB  - Cosmetic products were screened for total N-nitroso compounds by chemiluminescent measurement of nitric oxide liberated by the reductive cleavage of the N-nitroso group. The cosmetic was first partitioned between methylene chloride and water to separate polar and nonpolar N-nitroso compounds. Each extract was then examined for the presence of N-nitroso compounds by adding the cleavage reagent and sweeping the nitric oxide formed into a chemiluminescent analyzer. Although the method is not intended to be quantitative, recovery studies were conducted to determine measurable levels. Recovery studies of polar N-nitroso compounds were conducted by adding N-nitrosodiethanolamine (NDELA) to a cream, a shampoo, and a lotion at 3 levels, i.e., 80, 320, and 960 ppb, and then determining NDELA by the method. Recoveries ranged from 48 to 83% (mean 68%; SD = 11.9). For recoveries of nonpolar N-nitroso compounds, 100, 200, and 500 ppb of N-nitrosomethyltetradecylamine were added to the 3 cosmetic products. Recoveries ranged from 58 to 70% (mean 63%; SD = 5.3).
JF  - Journal - Association of Official Analytical Chemists
AU  - Chou, H J
AU  - Yates, R L
AU  - Wenninger, J A
AD  - Food and Drug Administration, Division of Colors and Cosmetics, Washington, DC 20204.
PY  - 1987
SP  - 960
EP  - 963
VL  - 70
IS  - 6
SN  - 0004-5756, 0004-5756
KW  - Cosmetics
KW  - 0
KW  - Indicators and Reagents
KW  - Nitrosamines
KW  - Nitroso Compounds
KW  - N-nitrosodiethanolamine
KW  - 30YI1289VY
KW  - Nitric Oxide
KW  - 31C4KY9ESH
KW  - Diethylnitrosamine
KW  - 3IQ78TTX1A
KW  - Methylene Chloride
KW  - 588X2YUY0A
KW  - N-nitrosomethyltetradecylamine
KW  - 75881-20-8
KW  - Index Medicus
KW  - Diethylnitrosamine -- analogs & derivatives
KW  - Diethylnitrosamine -- analysis
KW  - Luminescent Measurements
KW  - Nitrosamines -- analysis
KW  - Nitric Oxide -- analysis
KW  - Cosmetics -- analysis
KW  - Nitroso Compounds -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-25
N1  - Date created - 1988-03-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Study of the teratogenic potential of guar gum.
AN  - 77875173; 3692386
AB  - Guar gum in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats for 13 wk before mating, during mating and throughout gestation. During gestation, the females consumed 0, 0.7, 1.4, 2.7, 5.2 or 11.8 g guar gum/kg of body weight/day, respectively. The animals were killed on gestation day 20. No behavioural effects were seen in any of the treated dams, and no females died during the experiment. Pregnant females in the treated groups consumed less food than the controls during gestation days 0-20 but the decrease was significant only in the 4 and 7.5% groups and was not dose related. Ingestion of guar gum before mating did not affect fertility. In the dams fed 1-7.5% guar gum, there was no effect on the number of corpora lutea or implantations. The dams fed 15% guar gum had slightly fewer corpora lutea and implantations than the controls but no effect was seen on implantation efficiency in this group. The number of viable foetuses/litter was also reduced slightly but not significantly in the 15% group, but since the number of resorptions was not affected, this decrease appears to be an effect of the decreased number of corpora lutea. There was no compound-related effect on foetal development or sex distribution. No terata were seen.
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Collins, T F
AU  - Welsh, J J
AU  - Black, T N
AU  - Graham, S L
AU  - O'Donnell, M W
AD  - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 807
EP  - 814
VL  - 25
IS  - 11
SN  - 0278-6915, 0278-6915
KW  - Galactans
KW  - 0
KW  - Mannans
KW  - Plant Gums
KW  - guar gum
KW  - E89I1637KE
KW  - Index Medicus
KW  - Rats
KW  - Eating -- drug effects
KW  - Animals
KW  - Fetus -- drug effects
KW  - Dose-Response Relationship, Drug
KW  - Bone and Bones -- abnormalities
KW  - Body Weight -- drug effects
KW  - Male
KW  - Female
KW  - Mannans -- toxicity
KW  - Galactans -- toxicity
KW  - Abnormalities, Drug-Induced -- etiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-12
N1  - Date created - 1988-02-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Comparative tissue distribution and excretion of [1-14C]acrylamide in beagle dogs and miniature pigs.
AN  - 77860161; 3692391
AB  - Male beagle dogs and miniature pigs were given acrylamide in the diet for 3-4 wk at a dosage of 1 mg/kg/day. They were then given [1-14C]acrylamide as a single oral dose of 1 mg/kg. The animals were killed 6 hr or 1, 2, 4 or 14 days after administration of the radioactive compound and tissues were analysed for radioactivity. The radiolabelled material was distributed to a major extent in muscle tissue in both species (31-35% of the dose at 6 hr and 5-7% at 14 days). Although the nervous system is the primary target for acrylamide monomer toxicity, less than 1% of the administered 14C was found in the brain in both species. No neurotoxic signs were evident during the exposure period at the dosage used. Analysis of discrete areas of the brain for radioactivity revealed that the levels of penetration of [1-14C]acrylamide in brain paralleled the vascularization pattern of the tissues. Approximately 60% of the administered radiolabel was excreted in the urine in both species and smaller amounts were excreted in the faeces. However, recovery in the faeces was higher in pigs (c. 25%) than in dogs (c. 7%) and this and the considerably higher levels demonstrated in the gastro-intestinal tract of the pigs indicated that the absorption of acrylamide was more rapid and more extensive in dogs than in pigs.
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Ikeda, G J
AU  - Miller, E
AU  - Sapienza, P P
AU  - Michel, T C
AU  - Inskeep, P B
AD  - Division of Toxicology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 871
EP  - 875
VL  - 25
IS  - 11
SN  - 0278-6915, 0278-6915
KW  - Acrylamides
KW  - 0
KW  - Carbon Radioisotopes
KW  - Acrylamide
KW  - 20R035KLCI
KW  - Index Medicus
KW  - Swine
KW  - Animals
KW  - Spinal Cord -- metabolism
KW  - Dogs
KW  - Intestinal Absorption
KW  - Brain -- metabolism
KW  - Tissue Distribution
KW  - Swine, Miniature
KW  - Species Specificity
KW  - Male
KW  - Acrylamides -- pharmacokinetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-12
N1  - Date created - 1988-02-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Lung cancer mortality in workers exposed to sulfuric acid mist and other acid mists.
AN  - 77842758; 3479642
AB  - Mortality patterns were studied in 1,165 workers exposed to sulfuric acid mist and other acid mists (primarily hydrochloric acid mist) in steel-pickling operations. Standardized mortality ratio (SMR) analysis of the full "any acid exposure" cohort (n = 1,165), with the use of U.S. death rates as a standard, showed that lung cancer was significantly elevated, with a mortality ratio of 1.64 [95% confidence interval (CI) = 1.14-2.28, based on 35 observed deaths]. The lung cancer mortality ratio for workers exposed only to sulfuric acid (n = 722) was lower (SMR = 1.39), but further restriction to the time 20 years and more from first employment in a job with probable daily sulfuric acid exposure (approximately equal to 0.2 mg/m3) yielded a mortality ratio of 1.93 (95% CI = 1.10-3.13). An excess lung cancer risk was also seen in workers exposed to acids other than sulfuric acid (SMR = 2.24; 95% CI = 1.02-2.46). When comparison was made to other steel workers (rather than to the U.S. general population) to control for socioeconomic and life-style factors such as smoking, the largest lung cancer excess was again seen in workers exposed to acids other than sulfuric acid (SMR = 2.00; 95% CI = 1.06-3.78). Adjustment for potential differences in smoking habits showed that increased smoking was unlikely to have entirely explained the increased risk. Mortality from causes of death other than lung cancer was unremarkable, with the exception of significantly low rates for deaths due to digestive system diseases.
JF  - Journal of the National Cancer Institute
AU  - Beaumont, J J
AU  - Leveton, J
AU  - Knox, K
AU  - Bloom, T
AU  - McQuiston, T
AU  - Young, M
AU  - Goldsmith, R
AU  - Steenland, N K
AU  - Brown, D P
AU  - Halperin, W E
AD  - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 911
EP  - 921
VL  - 79
IS  - 5
SN  - 0027-8874, 0027-8874
KW  - Sulfuric Acids
KW  - 0
KW  - sulfuric acid
KW  - O40UQP6WCF
KW  - Index Medicus
KW  - United States
KW  - Age Factors
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Particle Size
KW  - Aged
KW  - Smoking -- adverse effects
KW  - Digestive System Diseases -- mortality
KW  - Laryngeal Neoplasms -- mortality
KW  - Adult
KW  - Middle Aged
KW  - Adolescent
KW  - Time Factors
KW  - Sulfuric Acids -- adverse effects
KW  - Lung Neoplasms -- mortality
KW  - Lung Neoplasms -- chemically induced
KW  - Occupational Diseases -- chemically induced
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-18
N1  - Date created - 1987-12-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Body burden profiles of single and mixed solvent exposures.
AN  - 77814715; 3681498
AB  - The dynamics of inhaled solvents have not been studied extensively for exposure conditions involving combinations of chemical agents. An ongoing laboratory study examining psychomotor performance effects on human volunteers exposed to spray paint agents offered an opportunity to gather data on the body burden profiles produced by the inhalation of two solvents alone and in combination. Breath and blood samples were collected from 70 male and female subjects who were randomly assigned to four treatment conditions: chemical placebo, 250 ppm acetone, 200 ppm methyl ethyl ketone, or 125 ppm acetone/100 ppm methyl ethyl ketone. The exposures lasted for four hours. No interaction between the two solvents affecting uptake or elimination was noted. There were no significant differences between the uptake and elimination in males and females. The results are discussed in relation to physiological simulation modeling of the exposure.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Brown, W D
AU  - Setzer, J V
AU  - Dick, R B
AU  - Phipps, F C
AU  - Lowry, L K
AD  - Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 877
EP  - 883
VL  - 29
IS  - 11
SN  - 0096-1736, 0096-1736
KW  - Butanones
KW  - 0
KW  - Solvents
KW  - Acetone
KW  - 1364PS73AF
KW  - methylethyl ketone
KW  - 6PT9KLV9IO
KW  - Index Medicus
KW  - Environmental Monitoring
KW  - Humans
KW  - Body Burden
KW  - Adult
KW  - Acetone -- pharmacokinetics
KW  - Adolescent
KW  - Butanones -- pharmacokinetics
KW  - Male
KW  - Female
KW  - Breath Tests
KW  - Solvents -- blood
KW  - Solvents -- pharmacokinetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-21
N1  - Date created - 1988-01-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Metabolism of Pyrilamine Maleate in Fischer 344 Rats, Part I: Activity Excretion Profiles
AN  - 1093451763; 17184968
AB  - Male and female Fisher 344 rats (12 per group) were dosed by gavage with either 2 or 10 mg (based on the free amine) pyrilamine maleate containing about 12 and 6 A Delta *mCi 14C-pyrilamine maleate, respectively, to determine excretion of the activity as a function of dose and sex with time. Urine and feces were collected at timed intervals through 144 h. Most of the dose (about 70%) was eliminated within 48 h through the urine and feces, but only about 80% of the total dose was recovered during the experiment. Less than 1% of the total dose remained in the rats at the end of the test period. In an additional experiment to determine the location of the remainder of the dose (about 20%), male rats were dosed with 2 mg pyrilamine maleate containing 14C-pyrilamine maleate. After 144 h, exhaustive washing of the cages resulted in recovery of approximately 20% of the dose, thus identifying its location. There were no significant sex or dose related differences observed in the total amount of, 14C that was eliminated through the urine or feces and recovered. Urine and feces are the major routes of elimination of pyrilamine maleate in the Fischer 344 rat. The urinary route of elimination was more predominant than the fecal route in both sexes at either dose.
JF  - Journal of Analytical Toxicology
AU  - Thompson, Harold C
AU  - Holder, Claude L
AU  - Siitonen, Paul H
AU  - Rowland, Kenneth L
AU  - Gosnell, Aubrey B
AU  - Cmarik, Joan L
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079
Y1  - 1987/11//
PY  - 1987
DA  - November 1987
SP  - 252
EP  - 256
PB  - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States
VL  - 11
IS  - 6
SN  - 0146-4760, 0146-4760
KW  - Toxicology Abstracts
KW  - amines
KW  - Urine
KW  - Excretion
KW  - pyrilamine
KW  - Feces
KW  - Metabolism
KW  - Sex
KW  - X 24300:Methods
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L2  - http://www.ingentaconnect.com/content/oup/jat/1987/00000011/00000006/art00004
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2012-10-01
N1  - Last updated - 2016-02-04
N1  - SubjectsTermNotLitGenreText - amines; Urine; Excretion; Feces; pyrilamine; Metabolism; Sex
ER  - 



TY  - JOUR
T1  - A guide for mutagenicity testing using the dominant lethal assay.
AN  - 81034416; 3657832
AB  - The dominant lethal assay has been used and continues to be used to provide information about the effects of chemicals on the gonadal cells of male animals. Guidelines for conducting this test are useful but as with any guideline scientists should avoid interpreting them as protocols. Thus this document is a general approach to dominant lethal testing and should be used in conjunction with other available protocols and procedures.
JF  - Mutation research
AU  - Green, S
AU  - Lavappa, K S
AU  - Manandhar, M
AU  - Sheu, C J
AU  - Whorton, E
AU  - Springer, J A
AD  - U.S. Food and Drug Administration, Washington, DC 20204.
Y1  - 1987/10//
PY  - 1987
DA  - October 1987
SP  - 167
EP  - 174
VL  - 189
IS  - 2
SN  - 0027-5107, 0027-5107
KW  - Mutagens
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Reproduction -- drug effects
KW  - Statistics as Topic
KW  - Fetal Death -- chemically induced
KW  - Research Design
KW  - Male
KW  - Female
KW  - Embryo Implantation -- drug effects
KW  - Pregnancy
KW  - Mutagens -- analysis
KW  - Genes, Dominant
KW  - Mutagenicity Tests -- standards
KW  - Mutagens -- administration & dosage
KW  - Genes, Lethal
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-10-30
N1  - Date created - 1987-10-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Epidemiological-environmental study of diesel bus garage workers: chronic effects of diesel exhaust on the respiratory system.
AN  - 81022295; 2443345
AB  - Two hundred and eighty-three (283) male diesel bus garage workers from four garages in two cities were examined to determine if there was excess chronic respiratory morbidity related to diesel exposure. The dependent variables were respiratory symptoms, radiographic interpretation for pneumoconiosis, and pulmonary function (FVC, FEV1, and flow rates). Independent variables included race, age, smoking, drinking, height, and tenure (as surrogate measure of exposure). Exposure-effect relationships within the study population showed no detectable associations of symptoms with tenure. There was an apparent association of pulmonary function and tenure. Seven workers (2.5%) had category 1 pneumoconiosis (three rounded opacities, two irregular opacities, and one with both rounded and irregular). The study population was also compared to a nonexposed "blue-collar" population. After indirect adjustment for age, race, and smoking, the study population had elevated prevalences of cough, phlegm, and wheezing, but there was no association with tenure. Dyspnea showed a dose-response trend but no apparent increase in prevalence. Mean percent predicted pulmonary function of the study population was greater than 100%, i.e., elevated above the comparison population. These data show there is an apparent effect of diesel exhaust on pulmonary function but not chest radiographs. Respiratory symptoms are high compared to "blue-collar" workers, but there is no relationship with tenure.
JF  - Environmental research
AU  - Gamble, J
AU  - Jones, W
AU  - Minshall, S
AD  - National Institute for Occupational Safety and Health, Appalachian Laboratories for Occupational Safety and Health, Morgantown, West Virginia 26505.
Y1  - 1987/10//
PY  - 1987
DA  - October 1987
SP  - 6
EP  - 17
VL  - 44
IS  - 1
SN  - 0013-9351, 0013-9351
KW  - Vehicle Emissions
KW  - 0
KW  - Index Medicus
KW  - Respiratory Function Tests
KW  - Smoking
KW  - Age Factors
KW  - Body Height
KW  - Social Class
KW  - Humans
KW  - Continental Population Groups
KW  - Radiography
KW  - Alcohol Drinking
KW  - Time Factors
KW  - Occupational Diseases -- diagnostic imaging
KW  - Respiratory Tract Diseases -- etiology
KW  - Occupational Diseases -- etiology
KW  - Occupational Diseases -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-09
N1  - Date created - 1987-11-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Stereoselective fungal metabolism of 7,12-dimethylbenz[a]anthracene: identification and enantiomeric resolution of a K-region dihydrodiol.
AN  - 77919371; 3122656
AB  - Syncephalastrum racemosum UT-70 and Cunninghamella elegans ATCC 36112 metabolized 7,12-dimethylbenz[a]anthracene (7,12-DMBA) to hydroxymethyl metabolites as well as 7-hydroxymethyl-12-methylbenz[a]anthracene trans-3,4-, -5,6-, -8,9-, and -10,11-dihydrodiols. The 7,12-DMBA metabolites were isolated by reversed-phase high-performance liquid chromatography and identified by their UV-visible absorption, mass, and nuclear magnetic resonance spectral characteristics. A comparison of the circular dichroism spectra of the K-region (5,6-position) dihydrodiol of both fungal strains with those of the 7,12-DMBA 5S,6S-dihydrodiol formed from 7,12-DMBA by rat liver microsomes indicated that the major enantiomer of the 7-hydroxymethyl-12-methylbenz[a]anthracene trans-5,6-dihydrodiol formed by both fungal strains had a 5R,6R absolute stereochemistry. Direct resolution of the fungal trans-5,6-dihydrodiols by chiral stationary-phase high-performance liquid chromatography indicated that the ratios of the R,R and S,S enantiomers were 88:12 and 77:23 for S. racemosum and C. elegans, respectively. These results indicate that the fungal metabolism of 7,12-DMBA at the K region (5,6-position) is highly stereoselective and different from that reported for mammalian enzyme systems.
JF  - Applied and environmental microbiology
AU  - McMillan, D C
AU  - Fu, P P
AU  - Cerniglia, C E
AD  - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1987/10//
PY  - 1987
DA  - October 1987
SP  - 2560
EP  - 2566
VL  - 53
IS  - 10
SN  - 0099-2240, 0099-2240
KW  - 9,10-Dimethyl-1,2-benzanthracene
KW  - 57-97-6
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Stereoisomerism
KW  - Chemistry
KW  - Microsomes, Liver -- enzymology
KW  - Chemical Phenomena
KW  - Chromatography, High Pressure Liquid
KW  - Magnetic Resonance Spectroscopy
KW  - Mucorales -- metabolism
KW  - 9,10-Dimethyl-1,2-benzanthracene -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-02
N1  - Date created - 1988-02-02
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Biochem Pharmacol. 1970 Mar;19(3):795-818 [5507686]
Environ Res. 1986 Dec;41(2):400-19 [3780640]
J Am Chem Soc. 1976 Mar 31;98(7):1952-5 [1254854]
FEBS Lett. 1977 Oct 15;82(2):278-82 [410661]
Chem Biol Interact. 1978 Jan;20(1):17-26 [415819]
Cancer Lett. 1978 Mar;4(3):131-40 [417802]
Chem Biol Interact. 1978 Nov;23(2):243-57 [101308]
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5466-70 [103094]
Proc Natl Acad Sci U S A. 1979 Feb;76(2):862-6 [106395]
Cancer Lett. 1979 Apr;6(4-5):213-20 [108011]
Int J Cancer. 1979 Oct 15;24(4):455-60 [118940]
Chem Biol Interact. 1980 Mar;29(3):357-67 [6766815]
Annu Rev Pharmacol Toxicol. 1980;20:513-31 [6992704]
Cancer Res. 1980 Oct;40(10):3661-4 [6777036]
Cancer Res. 1981 Apr;41(4):1559-64 [6783297]
Carcinogenesis. 1981;2(2):115-9 [6791851]
Carcinogenesis. 1981;2(6):511-4 [6791859]
Mol Pharmacol. 1982 Jul;22(1):190-5 [6811857]
Appl Environ Microbiol. 1982 Sep;44(3):682-9 [7138006]
Cancer Res. 1983 Sep;43(9):4221-6 [6409399]
Cancer Res. 1983 Dec;43(12 Pt 1):5647-51 [6315214]
Biochem J. 1983 Nov 15;216(2):377-84 [6661203]
Appl Environ Microbiol. 1984 Jan;47(1):119-24 [6696409]
Biochem J. 1984 Nov 1;223(3):775-82 [6439187]
Anal Chem. 1984 Dec;56(14):2658-62 [6441482]
Adv Appl Microbiol. 1984;30:31-71 [6442534]
Biochem Biophys Res Commun. 1985 Jul 31;130(2):610-6 [3927907]
Biochem Pharmacol. 1970 Jul;19(7):2261-75 [5520373]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Phorbol ester enhances human immunodeficiency virus-promoted gene expression and acts on a repeated 10-base-pair functional enhancer element.
AN  - 77830099; 3500398
AB  - T-cell activation pathways are involved in the regulation of human immunodeficiency virus (HIV) expression. Phorbol 12-myristate 13-acetate (PMA) is a potent inducer of T-cell immune functions and has recently been demonstrated to increase viral replication in cell lines infected with HIV. To define sequences required for viral induction by PMA. T-cell lines were transiently transfected with viral long terminal repeat (LTR) sequences directing chloramphenicol acetyltransferase (CAT) gene expression. PMA added to transfected cell cultures 24 h before harvest reproducibly increased both CAT mRNA and enzyme expression 2- to 2-fold. Sequences necessary for basal and PMA-induced levels of CAT expression were determined by deletion and enhancer reconstitution constructs with fragments and oligonucleotides from the original LTR-CAT expression plasmid. PMA-inducible and basal activity required tandem repeats of a core enhancer element (GGGACTTTCC) located in the LTR between -105 and -82 relative to the RNA start site. The enhancerlike sequence could be inserted at a site distant to the CAT gene open reading frame and functioned in a position- and orientation-independent manner. The data thus define a transcriptionally active regulatory-enhancer element critical to the control of HIV gene expression.
JF  - Molecular and cellular biology
AU  - Kaufman, J D
AU  - Valandra, G
AU  - Roderiquez, G
AU  - Bushar, G
AU  - Giri, C
AU  - Norcross, M A
AD  - Division of Virology, Food and Drug Administration, Bethesda, Maryland 20892.
Y1  - 1987/10//
PY  - 1987
DA  - October 1987
SP  - 3759
EP  - 3766
VL  - 7
IS  - 10
SN  - 0270-7306, 0270-7306
KW  - DNA, Viral
KW  - 0
KW  - Tetradecanoylphorbol Acetate
KW  - NI40JAQ945
KW  - Index Medicus
KW  - AIDS/HIV
KW  - Transcription, Genetic -- drug effects
KW  - DNA Mutational Analysis
KW  - Chromosome Mapping
KW  - T-Lymphocytes -- microbiology
KW  - Enhancer Elements, Genetic
KW  - Tetradecanoylphorbol Acetate -- pharmacology
KW  - Gene Expression Regulation -- drug effects
KW  - Repetitive Sequences, Nucleic Acid
KW  - HIV -- genetics
KW  - DNA, Viral -- genetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-19
N1  - Date created - 1988-01-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Mol Cell Biol. 1982 Sep;2(9):1044-51 [6960240]
Nature. 1987 Apr 16-22;326(6114):711-3 [3031512]
Science. 1984 May 4;224(4648):497-500 [6200935]
Lancet. 1984 Sep 29;2(8405):711-6 [6148471]
Science. 1984 Dec 7;226(4679):1165-71 [6095449]
Science. 1985 Feb 1;227(4686):538-40 [2981438]
J Biol Chem. 1985 Feb 10;260(3):1366-9 [3155734]
JAMA. 1985 Apr 19;253(15):2219-23 [2983132]
Cell. 1985 Jun;41(2):521-30 [2985280]
Cell. 1985 Jul;41(3):813-23 [2988790]
Science. 1985 Jul 5;229(4708):69-73 [2990040]
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5530-4 [2991931]
Science. 1986 Feb 21;231(4740):850-3 [2418502]
Science. 1986 May 9;232(4751):755-9 [3008338]
Science. 1986 Jul 18;233(4761):305-12 [3014651]
J Virol. 1986 Aug;59(2):284-91 [3016298]
J Natl Cancer Inst. 1972 Sep;49(3):891-5 [4567231]
Biochemistry. 1979 Nov 27;18(24):5294-9 [518835]
Blood. 1980 Mar;55(3):409-17 [6244013]
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7575-8 [6278479]
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6453-7 [6292901]
Cell. 1986 Aug 29;46(5):705-16 [3091258]
Cell. 1986 Sep 26;46(7):973-82 [3530501]
Nature. 1986 Oct 9-15;323(6088):555-8 [3020435]
Virology. 1986 Oct 30;154(2):249-58 [3639669]
Science. 1986 Nov 21;234(4779):988-92 [3490693]
Cell. 1986 Dec 26;47(6):921-8 [3096580]
Science. 1986 Dec 19;234(4783):1552-7 [3491428]
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9734-8 [3025848]
Cell. 1987 Feb 27;48(4):691-701 [3643816]
Cell. 1987 Apr 10;49(1):47-56 [3030566]
Science. 1983 Feb 11;219(4585):626-31 [6297005]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Old Colony Mennonites in Mexico: Migration and Inbreeding
AN  - 60924706; 89U2418
AB  - Among Canadian Mennonites whose ancestors left Flanders in the sixteenth century, one group separated as the Old Colony & part migrated in the 1920s from Canada to Mexico, where they constitute a large inbred isolate. In 1967, survey data including migration histories were collected on 33% of the households (N not specified) in one subdivision or colony. Church records were copied that gave vital statistics & surnames of the approximately 3,500 families residing in the colony since the migration. Recent migration patterns show marriage restricted by distance & 37% of resident married Ms remaining in their village of birth; but M migration history for those who migrate within the colony shows almost no effect of distance. Analysis of surnames gives an estimate of cumulative inbreeding consistent with the individually estimated components, ie, founder effect, historical population constrictions, & slow genetic drift. 7 Tables, 19 References. HA
JF  - Social Biology
AU  - Allen, Gordon
AU  - Redekop, Calvin W
AD  - National Instit Mental Health US Public Health Service, Washington DC 20201
Y1  - 1987/10//
PY  - 1987
DA  - Oct 1987
SP  - 166
EP  - 179
VL  - 34
IS  - 3 -- 4
SN  - 0037-766X, 0037-766X
KW  - migration/inbreeding patterns, Canadian Mennonite colony, Mexico
KW  - household survey, church records
KW  - *Homogamy
KW  - *Migration Patterns
KW  - *Congregations
KW  - *Marriage Patterns
KW  - *Mexico
KW  - *Mennonites
KW  - *Religious Cultural Groups
KW  - article
KW  - 0514: culture and social structure; social anthropology
KW  - 1535: sociology of religion; sociology of religion
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Biology&rft.atitle=Old+Colony+Mennonites+in+Mexico%3A+Migration+and+Inbreeding&rft.au=Allen%2C+Gordon%3BRedekop%2C+Calvin+W&rft.aulast=Allen&rft.aufirst=Gordon&rft.date=1987-10-01&rft.volume=34&rft.issue=3+--+4&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Social+Biology&rft.issn=0037766X&rft_id=info:doi/
LA  - English
DB  - Sociological Abstracts
N1  - Date revised - 2007-04-01
N1  - Last updated - 2011-12-15
N1  - CODEN - SBGYA3
N1  - SubjectsTermNotLitGenreText - *Congregations; *Mennonites; *Religious Cultural Groups; *Marriage Patterns; *Homogamy; *Migration Patterns; *Mexico
ER  - 



TY  - BOOK
T1  - AIDS: a public health challenge; state issues, policies and programs
AN  - 59457817; 1988-0306076
AB  - V. 1, Assessing the problem; v. 2, Managing and financing the problem; v. 3, Resource guide.
JF  - Supt Docs, October 1987. 3v.
Y1  - 1987/10//
PY  - 1987
DA  - October 1987
PB  - Supt Docs
KW  - Public health -- United States
KW  - Acquired immune deficiency syndrome -- United States
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1987-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=AIDS%3A+a+public+health+challenge%3B+state+issues%2C+policies+and+programs&rft.title=AIDS%3A+a+public+health+challenge%3B+state+issues%2C+policies+and+programs&rft.issn=&rft_id=info:doi/
LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Supt Docs pa v 1 $11; v 2 $8; v 3 $6
N1  - Document feature - bibl(s), table(s), chart(s), map(s)
N1  - SuppNotes - 3v
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519945071
JF  - Alcohol Health and Research World
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944331
JF  - Alcohol Health and Research World
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944207
JF  - Alcohol Health and Research World
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - International Perspectives: Alcohol Abuse and Economic Underdevelopment in Guatemala
AN  - 1474330078
AB  - Effective treatment faces major challenges.
JF  - Alcohol Health and Research World
AU  - Coombs, David W
AU  - Lowe, John B
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 52
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Special Populations: The Triumph of the Alkali Lake Indian Band
AN  - 1474329861
JF  - Alcohol Health and Research World
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 57
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Use of Computer Models to Evaluate Prevention Strategies: An Interview with Harold Holder
AN  - 1474329023
AB  - An innovative tool addresses the political economy of prevention.
JF  - Alcohol Health and Research World
AU  - AMATETTI, SHARON LOW
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Report: Small Doses of Morphine Increase Alcohol Consumption
AN  - 1474328684
JF  - Alcohol Health and Research World
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 56
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Change in Alcoholic Beverage Prices and Legal Drinking Ages: Effects on Youth Alcohol Use and Motor Vehicle Mortality
AN  - 1474328084
AB  - Calculating the extent of prevention.
JF  - Alcohol Health and Research World
AU  - Coate, Douglas
AU  - Grossman, Michael
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 22
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol Advertising and Adolescent Drinking
AN  - 1474326764
AB  - What surveys can - and can't - tell us.
JF  - Alcohol Health and Research World
AU  - Lieberman, Lisa Rubin
AU  - Orlandi, Mario A
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 30
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Mini-Marts and Maxi-Problems: The Relationship Between Purchase and Consumption Location
AN  - 1474326253
AB  - The role of sales outlet type in impaired driving.
JF  - Alcohol Health and Research World
AU  - Ryan, Barbara E
AU  - Segars, Lance
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 26
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Justifying Alcohol Treatment on the Basis of Cost Savings: The "Offset" Literature
AN  - 1474325465
AB  - Recent findings challenge a decade of research.
JF  - Alcohol Health and Research World
AU  - Luckey, James W
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 8
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Readers' Exchange: California's Social Model of Treatment
AN  - 1474324473
JF  - Alcohol Health and Research World
AU  - COLTHURST, THOMAS
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 59
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 17: Proposed Coding of Alcohol's Role in Casualties
AN  - 1474302769
AB  - "Proposals for the 10th Revision of the" International Classification of Diseases.
JF  - Alcohol Health and Research World
AU  - Grant, Bridget F
AU  - Dufour, Mary
AU  - Stinson, Frederick
AU  - Towle, Leland
AU  - Bertolucci, Darryl
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Editor's Forum: Economic Research and Prevention
AN  - 1474302385
AB  - New studies investigate the environment of alcohol-related problems.
JF  - Alcohol Health and Research World
AU  - Casement, Mary R
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 16
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Consumer Demand Concepts and Relapse Prediction: An Interview with Rudy Vuchinich
AN  - 1474302371
AB  - Research on change in consumption borrows from economic theory.
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL J
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 44
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Southern Peach Brandy Versus Northern Hard Cider: The First Congress Debates the Duties on Distilled Spirits Act of 1791
AN  - 1474302179
AB  - Regional drinking patterns and economics flavored a tax issue.
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL J
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 34
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Public Sector and Private Sector Alcoholism Treatment: Economic Competition or Cooperation?
AN  - 1474301403
AB  - Speculation on the changing relationship.
JF  - Alcohol Health and Research World
AU  - Miranda, John De
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 40
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Getting on Top of the Bottom Line: Economics in the "Sixth Special Report on Alcohol and Health"
AN  - 1474301217
AB  - Excerpts from the Report highlight trends and recent research.
JF  - Alcohol Health and Research World
AU  - Casement, Mary R
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Occupational Arena: San Diego Conference Considers Economics and EAP's
AN  - 1474301169
JF  - Alcohol Health and Research World
Y1  - 1987///Fall
PY  - 1987
DA  - Fall 1987
SP  - 58
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Analyses of two-way chronic studies.
AN  - 81051609; 3117124
AB  - This paper proposes a method for analyzing tumor data from chronic studies when the experimental design includes combinations of two factors, for example, sex and dose. Both main effects and combined-effect (interaction) hypotheses are considered. A stratified log-rank statistic is presented for tests of no column or row (main) effects. The paper shows that when the numbers of animals in the cells are unequal and disproportional, the null distribution of the unstratified log-rank statistic does not have a chi-square distribution. Two simple models, additive and multiplicative, for representing the combined effect of row and column are considered under the proportional hazards model. A simple conservative statistic is proposed for testing the additivity of the row and column effects. A simulation experiment to examine the behavior of the null distribution of the combined-effect test statistic under the additive model and the power of the test against the multiplicative model is reported. The procedure is illustrated by analyzing mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) in yellow and agouti F1 female mice from a laboratory experiment.
JF  - Biometrics
AU  - Chen, J J
AU  - Kodell, R L
AD  - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 499
EP  - 509
VL  - 43
IS  - 3
SN  - 0006-341X, 0006-341X
KW  - 9,10-Dimethyl-1,2-benzanthracene
KW  - 57-97-6
KW  - Index Medicus
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Biometry
KW  - Analysis of Variance
KW  - Mice
KW  - Monte Carlo Method
KW  - Species Specificity
KW  - Female
KW  - Neoplasms -- chemically induced
KW  - Neoplasms -- etiology
KW  - Mammary Neoplasms, Experimental -- pathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-02
N1  - Date created - 1987-12-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Mutagenicity of nitrofurans in Salmonella typhimurium TA98, TA98NR and TA98/1,8-DNP6.
AN  - 81034266; 3309641
AB  - 8 representative 2-substituted 5-nitrofurans were assayed for mutagenicity in Salmonella typhimurium strains TA98, TA98NR and TA98/1,8-DNP6. The tested compounds were: 5-nitro-2-furanacrylic N-(5-nitro-2-furfurylidene)hydrazide (1); furazolidone (2); 5-nitro-2-furanacrolein (3); 5-nitro-2-furaldehyde semicarbazone (4); 5-nitro-2-furaldehyde (5); nitrofurantoin (6); 5-nitro-2-furaldehyde diacetate (7); and 5-nitro-2-furoic acid (8). These compounds exhibited markedly different mutagenic activities in TA98, and these mutagenicities were similar both in the presence and the absence of rat-liver hepatic S9 activation enzymes. The mutagenic responses ranged from potent (90-300 revertants/nmole, compounds 1-3), to medium (about 10 revertants/nmole, compounds 4 and 6), to weak (0-4 revertants/nmole, compounds 5, 7 and 8). The mutagenicity of 3 was similar in all 3 tester strains, while compound 8 was essentially inactive. The mutagenicities of 1, 4, 5 and 7 were decreased 30-75% in TA98NR, while 2 and 6 showed an even greater depression of activity in this strain. Compound 6 with S9 was about equally mutagenic in TA98 and TA98/1,8-DNP6, while the activities of 6 without S9 and 2 and 7 both with and without S9 were 50-75% lower in TA98/1,8-DNP6. Compounds 1, 4 and 5 were only about 5-10% as mutagenic in TA98/1,8-DNP6 as in TA98. These results suggest that: (i) nitrofurans and their S9-mediated metabolites have similar mutagenic potencies; (ii) with the possible exception of No. 3, nitroreduction is the major route of mutagenic activation for these nitrofurans; and (iii) for compounds 2, 6 and 7, both the presumed N-hydroxy and N,O-ester derivatives of the corresponding aminofuran metabolites appear to lead to mutations.
JF  - Mutation research
AU  - Ni, Y C
AU  - Heflich, R H
AU  - Kadlubar, F F
AU  - Fu, P P
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 15
EP  - 22
VL  - 192
IS  - 1
SN  - 0027-5107, 0027-5107
KW  - Mutagens
KW  - 0
KW  - Nitrofurans
KW  - Nitroreductases
KW  - EC 1.7.-
KW  - Index Medicus
KW  - Mutagenicity Tests
KW  - Dose-Response Relationship, Drug
KW  - Salmonella typhimurium -- drug effects
KW  - Structure-Activity Relationship
KW  - Nitroreductases -- deficiency
KW  - Nitrofurans -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-10-28
N1  - Date created - 1987-10-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Potential reversibility of skeletal effects in rats exposed in utero to caffeine.
AN  - 81023081; 3653820
AB  - Groups of Osborne-Mendel rats, killed at three time intervals following mating, were studied to determine whether prenatal skeletal ossification delays observed following low-level caffeine administration represent transient or persistent ossification problems. Group A litters were killed on gestation day 20; group B neonates were killed on post-natal day 0; and group C pups were killed on post-natal day 6. Within each group, dose levels of 0, 0.018, 0.036 or 0.07% caffeine in distilled water were available ad lib. to groups of 30-60 dams from gestation day 0 to day 20. Average daily caffeine consumption was 24.7-29.0 mg/kg body weight for the 0.018% group, 42.7-48.8 mg/kg body weight for the 0.036% group and 70.6-75.1 mg/kg body weight for the 0.07% group. In group A litters, the mean number of viable foetuses was significantly less in the mid-dose and high-dose animals than in the controls. In the same group, the average number of foetuses per litter with at least one sternebral ossification delay was increased significantly in all treated groups and the average number of foetuses per litter with at least two sternebral variations was significantly increased in the mid- and high-dose groups. The percentages of litters containing foetuses with at least two and at least three sternebral variations and the average number of foetuses per litter with at least three sternebral variations were significantly increased only in the high-dose group. Foetuses from the mid- and high-dose groups also had significant increases in certain skeletal defects, namely missing centra and reduced ossification of the dorsal arch. Foetuses from the high-dose group also had significant increases in bipartite supraoccipital, and reduced ossification of the hyoid, metacarpals and metatarsals. In group B, day 0 neonates from all treated groups showed a significantly increased incidence of delayed sternebral ossification (average number of foetuses per litter with one or more missing, incomplete or bipartite sternebrae). The percentages of litters containing neonates with delayed sternebral ossification were also increased significantly in all treated groups. Neonates from the 0.07% level in group B also exhibited a significant increase in the incidence of supernumerary rib bud, and in reduced ossification of the metacarpals, metatarsals and calcaneus bones. Significant increases were also seen, in group B, in the low- and mid-dose animals, respectively, in supernumery rib bud and in reduced ossification of the metatarsals.(ABSTRACT TRUNCATED AT 400 WORDS)
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Collins, T F
AU  - Welsh, J J
AU  - Black, T N
AU  - Whitby, K E
AU  - O'Donnell, M W
AD  - Division of Toxicology, Food and Drug Administration, Washington, DC 20204.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 647
EP  - 662
VL  - 25
IS  - 9
SN  - 0278-6915, 0278-6915
KW  - Caffeine
KW  - 3G6A5W338E
KW  - Index Medicus
KW  - Rats
KW  - Eating
KW  - Drinking
KW  - Body Weight
KW  - Animals
KW  - Gestational Age
KW  - Osteogenesis -- drug effects
KW  - Female
KW  - Animals, Newborn -- anatomy & histology
KW  - Pregnancy
KW  - Maternal-Fetal Exchange
KW  - Abnormalities, Drug-Induced
KW  - Caffeine -- toxicity
KW  - Bone and Bones -- abnormalities
KW  - Caffeine -- pharmacology
KW  - Bone and Bones -- embryology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-18
N1  - Date created - 1987-11-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Binding of cholera toxin to Giardia lamblia.
AN  - 81015502; 3116038
AB  - Binding of cholera toxin to Giardia lamblia was demonstrated by two slightly different methods: an immunofluorescence technique using antibody to cholera toxin and anti-rabbit immunoglobulin G conjugated to fluorescein isothiocyanate, and a one-step fluorescence method in which G. lamblia was incubated with the B subunit of cholera toxin conjugated to fluorescein isothiocyanate.
JF  - Journal of clinical microbiology
AU  - McCardell, B A
AU  - Madden, J M
AU  - Stanfield, J T
AU  - Tall, B D
AU  - Stephens, M J
AD  - Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 1786
EP  - 1788
VL  - 25
IS  - 9
SN  - 0095-1137, 0095-1137
KW  - Fluoresceins
KW  - 0
KW  - Thiocyanates
KW  - Cholera Toxin
KW  - 9012-63-9
KW  - Fluorescein-5-isothiocyanate
KW  - I223NX31W9
KW  - Index Medicus
KW  - Microscopy, Fluorescence
KW  - Animals
KW  - Giardiasis -- parasitology
KW  - Humans
KW  - Feces -- parasitology
KW  - Mice, Inbred C3H
KW  - Mice
KW  - Fluorescent Antibody Technique
KW  - Giardia -- metabolism
KW  - Cholera Toxin -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-20
N1  - Date created - 1987-11-20
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Am J Dis Child. 1975 Nov;129(11):1304-10 [1190162]
Infect Immun. 1977 Mar;15(3):988-92 [67084]
CRC Crit Rev Clin Lab Sci. 1977 Jun;7(4):373-91 [143358]
Pediatrics. 1977 Oct;60(4):486-91 [905014]
Infect Immun. 1985 Oct;50(1):243-9 [4044038]
N Engl J Med. 1981 Jan 1;304(1):24-8 [7191944]
Trans R Soc Trop Med Hyg. 1983;77(4):467-9 [6636273]
Infect Immun. 1984 Oct;46(1):152-8 [6384043]
Lancet. 1985 Sep 28;2(8457):691-3 [2863678]
Infect Immun. 1978 Sep;21(3):1036-9 [361573]
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Campylobacter diarrhea in an adult mouse model.
AN  - 78053955; 3504219
AB  - An adult mouse (18-20 g) model was developed for studying the pathogenesis of Campylobacter isolates. Iron-loaded BALB/c mice given 10(8)-10(9) Campylobacter colony forming units by intraperitoneal injection developed a severe mucoid diarrhea within 4 h. Severe diarrhea, consisting of unformed stools containing blood, mucus, and fecal leukocytes, persisted for 24 h. Diarrheal symptoms in surviving mice resolved gradually; no diarrhea was observed 5 days after inoculation. Mice not pretreated with iron developed no diarrheal symptoms, and no severe diarrhea was produced in mice inoculated orally. A transient (less than 24 h) bacteremia occurred in mice inoculated either orally or intraperitoneally. Liver, spleen, and kidney were positive for Campylobacter for 48 h; intestinal contents were positive for 5-7 days. Mice given greater than or equal to 10(10) colony forming units showed symptoms of endotoxemia (ruffled fur, inactivity, shaking, tearing, and hypothermia) and died without diarrheal symptoms. Mice given nonpathogenic Escherichia coli strain HB101, heat-killed C. jejuni cells (greater than 10(10)), C. jejuni lipopolysaccharide extract, or purified lipopolysaccharide from either Vibrio cholerae 569B or Salmonella typhimurium showed no diarrheal symptoms.
JF  - Microbial pathogenesis
AU  - Stanfield, J T
AU  - McCardell, B A
AU  - Madden, J M
AD  - Division of Microbiology, Food and Drug Administration, Washington DC 20204.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 155
EP  - 165
VL  - 3
IS  - 3
SN  - 0882-4010, 0882-4010
KW  - Endotoxins
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Intestines -- pathology
KW  - Lethal Dose 50
KW  - Intestinal Mucosa -- microbiology
KW  - Intestinal Mucosa -- pathology
KW  - Sepsis -- microbiology
KW  - Mice
KW  - Endotoxins -- toxicity
KW  - Microscopy, Electron, Scanning
KW  - Campylobacter -- pathogenicity
KW  - Disease Models, Animal -- microbiology
KW  - Diarrhea -- pathology
KW  - Diarrhea -- microbiology
KW  - Disease Models, Animal -- pathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-01-11
N1  - Date created - 1989-01-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Risk of lung cancer among iron ore miners: a proportional mortality study of 1,075 deceased miners in Lorraine, France.
AN  - 77849747; 3681511
AB  - A proportional mortality study of 1,075 iron ore miners in Lorraine, France, who died between 1960 and 1976 showed a significant excess of lung cancer mortality (proportionate mortality ratio = 2.25). Moreover, proportionate lung cancer mortality increased with the duration of work underground (proportionate mortality ratio = 4.24 for subjects who worked underground for more than 30 years) and was higher among pneumoconiotic (siderotic) miners (proportionate mortality ratio = 3.85) than among nonpneumoconiotic miners. These results were confirmed by a case-control study nested in the mortality study. Smoking habits could not be estimated retrospectively with sufficient accuracy to be taken into account. Although the proportion of smokers among contemporary iron ore miners is larger than in the French male population, occupational factors may also play a role; radiation exposure can be ruled out because there is no detectable radioactivity in the Lorraine mines, but dust exposure may be considered as an etiologic factor owing to the relationship between siderosis and lung cancer.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Mur, J M
AU  - Meyer-Bisch, C
AU  - Pham, Q T
AU  - Massin, N
AU  - Moulin, J J
AU  - Cavelier, C
AU  - Sadoul, P
AD  - INRS French National Institute for Occupational Safety and Health, Vandoeuvre-les-Nancy.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 762
EP  - 768
VL  - 29
IS  - 9
SN  - 0096-1736, 0096-1736
KW  - Index Medicus
KW  - France
KW  - Age Factors
KW  - Risk Factors
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Lung Neoplasms -- mortality
KW  - Mining
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-21
N1  - Date created - 1987-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Allergic contact dermatitis from a nonbisphenol A epoxy in a graphite fiber reinforced epoxy laminate.
AN  - 77849702; 3681510
AB  - An employee of the Composites Division of an aircraft engine manufacturing firm developed dermatitis associated with the handling of a graphite fiber reinforced epoxy laminate (epoxy prepreg). Patch test investigation demonstrated that the responsible causal agent was the nonbisphenol A epoxy binder, 4-glycidyloxy-N, N-diglycidylaniline. A patch test with bisphenol A epoxy from a standard patch test screening series was negative. Subsequent interviews with employees of the Composites Division suggested that a relative lack of awareness of the cutaneous hazards of fiber reinforced epoxy laminates, compared with liquid epoxy resin systems, may be an important risk factor for allergic sensitization to these composite materials.
JF  - Journal of occupational medicine. : official publication of the Industrial Medical Association
AU  - Mathias, C G
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 754
EP  - 755
VL  - 29
IS  - 9
SN  - 0096-1736, 0096-1736
KW  - Epoxy Compounds
KW  - 0
KW  - Epoxy Resins
KW  - Ethers, Cyclic
KW  - 4-glycidyloxy-N,N-diglycidylaniline homopolymer
KW  - 31305-88-1
KW  - Index Medicus
KW  - Humans
KW  - Adult
KW  - Male
KW  - Epoxy Compounds -- adverse effects
KW  - Epoxy Resins -- adverse effects
KW  - Ethers, Cyclic -- adverse effects
KW  - Dermatitis, Contact -- etiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-21
N1  - Date created - 1987-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Immunogenetically controlled autoimmune reactions induced by mercury, gold and D-penicillamine in laboratory animals: a review from the vantage point of premarketing safety studies.
AN  - 77842197; 3317993
AB  - Mercury and gold salts as well as d-penicillamine can cause glomerulonephritis by an autoimmune mechanism in man. The susceptibility to this effect of these chemicals is controlled by the genes of the major histocompatibility complex (MHC). The presence of certain alleles confers sensitivity. The role of MHC-linked genes has been demonstrated also in the rat and mouse in the development of autoimmunity induced by these chemicals. While Brown Norway rats and ASW mice were sensitive, several other strains were resistant. Also an interaction of MHC with background genes has been shown in determination of the response to HgCl2. In conventional toxicity studies, use of a single inbred strain of laboratory animals obviously handicaps the detection of a reaction of this nature.
JF  - Toxicology and industrial health
AU  - Balazs, T
AD  - Drug Biology Division, Food and Drug Administration, Washington, DC 20204.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 331
EP  - 336
VL  - 3
IS  - 3
SN  - 0748-2337, 0748-2337
KW  - Gold
KW  - 7440-57-5
KW  - Mercury
KW  - FXS1BY2PGL
KW  - Penicillamine
KW  - GNN1DV99GX
KW  - Index Medicus
KW  - Rats
KW  - Mice, Inbred Strains
KW  - Animals
KW  - Mice
KW  - Glomerulonephritis -- chemically induced
KW  - Rats, Inbred BN
KW  - Glomerulonephritis -- immunology
KW  - Gold -- toxicity
KW  - Penicillamine -- toxicity
KW  - Autoimmune Diseases -- chemically induced
KW  - Mercury -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-18
N1  - Date created - 1987-12-18
N1  - Date revised - 2017-02-15
N1  - Last updated - 2017-02-15
ER  - 



TY  - JOUR
T1  - Thin-layer chromatographic determination of sterigmatocystin in cheese: interlaboratory study.
AN  - 77841692; 3680122
AB  - A collaborative study of a method for the determination of sterigmatocystin in cheese was conducted by 10 laboratories. The study included control samples and samples spiked at levels of 5, 10, and 25 ppb, in coded blind pairs. Recoveries were 60.0, 90.7, and 59.3%, outliers excluded, for the respective levels. The mean reproducibilities, outliers excluded, were 81.97, 17.13, and 52.77%, respectively. Mean repeatabilities, outliers excluded, were 77.66, 17.13, and 46.40%, respectively. Results of this collaborative study indicate that the method, modified as described in this report, is applicable to the determination of sterigmatocystin in cheese at low levels (5-50 ppb) for the purpose of surveys. With regard to the difficulty with thin-layer chromatography in this study, it is recommended that a more satisfactory determinative step be developed. Recommendation for official first action status is deferred.
JF  - Journal - Association of Official Analytical Chemists
AU  - Francis, O J
AU  - Ware, G M
AU  - Carman, A S
AU  - Kirschenheuter, G P
AU  - Kuan, S S
AU  - Newell, R F
AD  - Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122.
PY  - 1987
SP  - 842
EP  - 844
VL  - 70
IS  - 5
SN  - 0004-5756, 0004-5756
KW  - Xanthenes
KW  - 0
KW  - Sterigmatocystin
KW  - 10048-13-2
KW  - Index Medicus
KW  - Food Microbiology
KW  - Chromatography, Thin Layer
KW  - Xanthenes -- analysis
KW  - Sterigmatocystin -- analysis
KW  - Cheese -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-21
N1  - Date created - 1987-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Using average lifetime dose rate for intermittent exposures to carcinogens.
AN  - 77834643; 3685541
AB  - The effect of using the average dose rate over a lifetime as a representative measure of exposure to carcinogens is investigated by comparing the true theoretical multistage intermittent-dosing lifetime low-dose excess risk to the theoretical multistage continuous-dosing lifetime risk corresponding to the average lifetime dose rate. It is concluded that low-dose risk estimates based on the average lifetime dose rate may overestimate the true risk by several orders of magnitude, but that they never underestimate the true risk by more than a factor of k/r, where k is the total number of stages in the multistage model and r is the number of stages that are dose-related.
JF  - Risk analysis : an official publication of the Society for Risk Analysis
AU  - Kodell, R L
AU  - Gaylor, D W
AU  - Chen, J J
AD  - Biometry Staff, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 339
EP  - 345
VL  - 7
IS  - 3
SN  - 0272-4332, 0272-4332
KW  - Carcinogens
KW  - 0
KW  - Index Medicus
KW  - Risk Factors
KW  - Humans
KW  - Environmental Exposure
KW  - Statistics as Topic
KW  - Carcinogens -- administration & dosage
KW  - Carcinogens -- toxicity
KW  - Models, Biological
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-29
N1  - Date created - 1987-12-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Teratogenic Potential of Triphenyl Phosphate in Sprague-Dawley (Spartan) Rats
AN  - 760215300; 13641412
AB  - Male and female Sprague-Dawley (Spartan) rats were fed dietary levels of 0, 0.25, 0.50, 0.75 or 1.00% triphenyl phosphate (TPP) from 4 weeks post weaning for 91 days, through mating and gesta tion. At these dietary levels, the daily intake of TPP during preg nancy was 0, 166, 341, 516 and 690 mg/kg body weight, respectively. TPP exposure had no toxic effects on mothers or offspring at these dosages. The types of developmental anomalies were similar in both treated and control animals. No significant increases in the incidence of anomalies were seen in the treated groups as compared to control values. TPP was not teratogenic in Sprague-Dawley rats at the levels tested.
JF  - Toxicology and Industrial Health
AU  - Welsh, John J
AU  - Collins, Thomas FX
AU  - Whitby, Karen E
AU  - Black, Thomas N
AU  - Arnold, Alphonso
AD  - Division of Toxicology Food and Drug Administration Washington, DC
Y1  - 1987/09//
PY  - 1987
DA  - Sep 1987
SP  - 357
EP  - 369
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 3
IS  - 3
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - Mating
KW  - Phosphate
KW  - Body weight
KW  - Weaning
KW  - Teratogenicity
KW  - Progeny
KW  - X 24350:Industrial Chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 11
N1  - Last updated - 2015-03-19
N1  - SubjectsTermNotLitGenreText - Mating; Body weight; Phosphate; Weaning; Progeny; Teratogenicity
DO  - http://dx.doi.org/10.1177/074823378700300308
ER  - 



TY  - GEN
T1  - Health Manpower Shortage Area Designation Workshop, Volume I (New Orleans, Louisiana, November 5-7, 1986). Office of Data Analysis and Management Report No. 7-87.
AN  - 63211189; ED288437
AB  - Proceedings of the November 1986 Workshop on Health Manpower Shortage Area (HMSA) Designation are presented. The workshop was designed to facilitate cooperative efforts among the different federal and state health agencies that are involved in the planning and delivery of health care services. The purpose of the workshop was to improve understanding and use of the HMSA designation criteria and guidelines and to solicit recommendations on how to improve the process and procedures. Contents include: a review of the mission and organization of the Health Resources and Services Administration, background information on health manpower shortage area designation, the current criteria for designating shortage areas, and the role of state agencies. Additional contents cover: trends in the geographic distribution and diffusion of physicians and the projected impact on the number of HMSAs and number needed; the involvement of the American Medical Association in the HMSA review process; problems with HMSA designation; federal and state programs related to HMSA designation; professional association involvement in the HMSA review process; and current efforts at revising HMSA criteria and guidelines. The workshop agenda and a list of participants are appended. (SW)
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 202
KW  - American Medical Association
KW  - Health Manpower Shortage Areas
KW  - Health Resources and Services Administration
KW  - ERIC, Resources in Education (RIE)
KW  - Professional Associations
KW  - Government Role
KW  - Geographic Distribution
KW  - State Agencies
KW  - Higher Education
KW  - Federal Government
KW  - Health Services
KW  - Evaluation Criteria
KW  - Agency Role
KW  - Health Personnel
KW  - Physicians
KW  - Labor Supply
KW  - Federal State Relationship
KW  - Demand Occupations
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63211189?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - For Volume II, see HE 020 934.
N1  - Last updated - 2014-03-21
ER  - 



TY  - GEN
T1  - Health Manpower Shortage Area Designation Workshop, Volume II (San Diego, California, March 11-13, 1987). Office of Data Analysis and Management Report No. 7-87.
AN  - 63207244; ED288438
AB  - Proceedings of the March 1987 Workshop on Health Manpower Shortage Area (HMSA) Designation are presented. The workshop was designed to facilitate cooperative efforts among the different federal and state health agencies that are involved in the planning and delivery of health care services. Contents include: a review of the mission and organization of the Health Resources and Services Administration, background information on health manpower shortage area designation, the current criteria for designating shortage areas, and the role of state agencies. Additional contents cover: trends in the geographic distribution and diffusion of physicians; current criteria and guidelines for designating HMSAs; methods employed by state agencies in geographic HMSA designation; federal programs related to HMSA designation; the National Health Service Corps; the involvement of professional associations in the HMSA process/data; methods employed by state agencies in population group HMSA designation; state programs involved in HMSA designation; and current developments in HMSA designations. Appended are a workshop agenda and a list of participants. (SW)
Y1  - 1987/09//
PY  - 1987
DA  - September 1987
SP  - 115
KW  - Health Manpower Shortage Areas
KW  - Health Resources and Services Administration
KW  - ERIC, Resources in Education (RIE)
KW  - Professional Associations
KW  - Government Role
KW  - Geographic Distribution
KW  - State Agencies
KW  - Higher Education
KW  - Federal Government
KW  - Health Services
KW  - Evaluation Criteria
KW  - Agency Role
KW  - Health Personnel
KW  - Physicians
KW  - Labor Supply
KW  - Federal State Relationship
KW  - Demand Occupations
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63207244?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - For Volume I, see HE 020 933.
N1  - Last updated - 2014-03-21
ER  - 



TY  - GEN
T1  - Regulatory Requirements for Devices for the Handicapped.
AN  - 63018026; ED314928
AB  - This booklet explains in question/answer form the basic regulatory requirements established by the Food and Drug Administration (FDA) of the federal government concerning the manufacture, marketing and distribution of medical devices (including implantable devices and devices previously regulated as drugs) for persons with disabilities. Topics covered include: the definition of a handicapped person, classification of medical devices (according to the amont of control needed to assure the device's safety and effectiveness), implantable devices, devices previously regulated as drugs (transitional devices), registration and listing, premarket notification, good manufacturing practices, performance standards, premarket approval, investigational device exemptions, custom devices, trade secrets and confidential information, and color additives for devices. (PB)
AU  - Stigi, John
AU  - Rivera, Richard J.
Y1  - 1987/08//
PY  - 1987
DA  - August 1987
SP  - 35
KW  - ERIC, Resources in Education (RIE)
KW  - Sensory Aids
KW  - Biomedical Equipment
KW  - Disabilities
KW  - Mobility Aids
KW  - Federal Regulation
KW  - Compliance (Legal)
KW  - Prostheses
KW  - Communication Aids (for Disabled)
KW  - Assistive Devices (for Disabled)
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63018026?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Births of Hispanic Parentage, 1983 and 1984.
AN  - 63179422; ED286958
AB  - Twenty-three states and the District of Columbia collected information on births of Hispanic parentage in 1983 and 1984. More than 92% of the total Hispanic population in the United States resided in those states at this time. This report summarizes the available demographic information and presents data on births of Hispanic parentage in the following categories: (1) geographic distribution; (2) race of the child; (3) birth and fertility rates; (4) age of mother and live birth order; (5) childbearing by unmarried women; (6) educational attainment of mother; (7) nativity of mother; (8) prenatal care and number of prenatal visits to a health care professional; (9) low birth weight; (10) preterm births; (11) Apgar scores, which measure health factors of an infant at birth; and (12) health care attendant at birth and place of delivery. Comparisons are made with the parentage of non-Hispanic Blacks and Whites. Fourteen tables of statistics accompany this report. (VM)
AU  - Ventura, Stephanie J.
Y1  - 1987/07/24/
PY  - 1987
DA  - 1987 Jul 24
SP  - 20
VL  - DHHS/PHS-87-1120
KW  - ERIC, Resources in Education (RIE)
KW  - Demography
KW  - Birth Weight
KW  - Birth Order
KW  - Hispanic Americans
KW  - Birth Rate
KW  - Unwed Mothers
KW  - Educational Attainment
KW  - Population Trends
KW  - Parents
KW  - Prenatal Influences
KW  - Pregnancy
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63179422?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - For the reports for 1980 and 1981, see ED 245 055
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Knuckle pads in live-chicken hangers.
AN  - 81013767; 2958209
AB  - A study of live-chicken hangers in a poultry processing plant demonstrated a high prevalence of callosities over the knuckles (knuckle pads) of both hands. Knuckle pads were observed in 56% (23/41) of live-chicken hangers, but in no (0/41) workers from other departments (p less than 0.001). The probable cause was the repeated striking and sliding of the knuckles against metal shackles in which live birds were being placed. Additional medical and ergonomic evaluation would be worthwhile to confirm the probable cause, to determine whether associated tissue disorders are present in the digits of chicken hangers who develop knuckle pads, and to suggest preventive measures.
JF  - Contact dermatitis
AU  - Richards, T B
AU  - Gamble, J F
AU  - Castellan, R M
AU  - Mathias, C G
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505.
Y1  - 1987/07//
PY  - 1987
DA  - July 1987
SP  - 13
EP  - 16
VL  - 17
IS  - 1
SN  - 0105-1873, 0105-1873
KW  - Index Medicus
KW  - Fingers
KW  - Animals
KW  - Humans
KW  - Adult
KW  - Male
KW  - Poultry
KW  - Dermatitis, Occupational -- etiology
KW  - Food-Processing Industry
KW  - Callosities -- etiology
KW  - Hand Dermatoses -- etiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81013767?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contact+dermatitis&rft.atitle=Knuckle+pads+in+live-chicken+hangers.&rft.au=Richards%2C+T+B%3BGamble%2C+J+F%3BCastellan%2C+R+M%3BMathias%2C+C+G&rft.aulast=Richards&rft.aufirst=T&rft.date=1987-07-01&rft.volume=17&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Contact+dermatitis&rft.issn=01051873&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-18
N1  - Date created - 1987-11-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - BOOK
T1  - An annotated bibliography of scientific articles on AIDS for policymakers
AN  - 59458895; 1988-0307597
AB  - Prepared by Abt Associates Inc., Cambridge, Massachusetts, for the Office of the Assistant Secretary for Health: Health Planning and Evaluation. Cross section of policy-relevant studies on acquired immune deficiency syndrome research in the US and abroad published in scientific journals, Jan. 1985-Dec. 1986; covers a broad range of biomedical, epidemiological, educational, and economic topics. Contents: Prevalence and spread of AIDS/HTLV-III/LAV; Transmission modes; Characteristics of disease; Treatments for AIDS; Risk reduction; Related policy issues; Related scientific issues.
JF  - Supt Docs, July 1987.
AU  - Korda, Holly
Y1  - 1987/07//
PY  - 1987
DA  - July 1987
PB  - Supt Docs
KW  - Public health -- Bibliography
KW  - Acquired immune deficiency syndrome -- Abstracts
KW  - Acquired immune deficiency syndrome -- Bibliography
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Supt Docs pa U.S. $30; elsewhere $37.50
N1  - Document feature - bibl(s), table(s), chart(s)
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519945128
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519945100
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944353
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Cocaine Abuse Treatment in Maine: An Integrated Approach
AN  - 1474329424
AB  - Issues in treating multiple addictions in one program.
JF  - Alcohol Health and Research World
AU  - Thorpe, Geoffrey
AU  - Bush, Mary Jane
AU  - Magill, Sandi
AU  - Parker, Jefferson
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcoholism in the Invisible Minority: Some Appalachian Issues
AN  - 1474327904
JF  - Alcohol Health and Research World
AU  - Delaney, Terry
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 85
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Change from a Perspective of 5 Years
AN  - 1474327612
AB  - Highlights of the Midcourse Review of the 1990 Objectives.
JF  - Alcohol Health and Research World
AU  - Casement, Mary R
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 32
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - And I Will Stand the Hazard of the Die: Risk-Taking and Alcohol Use Among Washington, DC, Adolescents
AN  - 1474327273
AB  - Does a preference for risk-taking affect adolescent drinking decisions?
JF  - Alcohol Health and Research World
AU  - Keyser-Smith, Jennifer
AU  - STOIL, MICHAEL J
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Prevention Primer: Putting Theory To Work in the Classroom
AN  - 1474326917
AB  - Concepts behind school-based alcohol prevention approaches.
JF  - Alcohol Health and Research World
AU  - AMATETTI, SHARON LOW
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 38
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Safety Update
AN  - 1474326911
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 91
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 16: Combined Alcohol and Other Drug Use and Abuse - A Status Report
AN  - 1474326792
JF  - Alcohol Health and Research World
AU  - Norton, Robyn
AU  - Noble, John
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 78
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Alcohol, Expectancy, and Emotional States
AN  - 1474326249
AB  - How drinking patterns may be affected by beliefs about alcohol's effects.
JF  - Alcohol Health and Research World
AU  - Marlatt, G Alan
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 10
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Before the Cameras Turn: The Research Base of the Youth Alcohol Prevention Campaign
AN  - 1474325327
AB  - Sophisticated tools aided development of "Be Smart! Don't Start!"
JF  - Alcohol Health and Research World
AU  - Funkhouser, Judith E
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 44
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - News Notes
AN  - 1474325058
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 89
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Training Primary Care Physicians To Identify and Treat Substance Abuse
AN  - 1474323760
AB  - Results of analyses of current needs by four medical specializations.
JF  - Alcohol Health and Research World
AU  - Cotter, Frances
AU  - Callahan, Claire
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 70
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
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TY  - JOUR
T1  - Bizz-Buzz, Turtles, Quarters, and One Horse Club
AN  - 1474323695
AB  - The role of drinking games among high school and college students.
JF  - Alcohol Health and Research World
AU  - Douglas, Paul
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 54
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474323685
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 88
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Does Server Intervention Training Make a Difference? An Empirical Field Evaluation
AN  - 1474323602
AB  - Effects of a training program on patron drinking and tipping.
JF  - Alcohol Health and Research World
AU  - Geller, E Scott
AU  - Russ, Nason W
AU  - DELPHOS, WILLIAM A
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 64
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Cocaine-Induced Liver Injury
AN  - 1474303129
AB  - Plotting a possibly lethal chain of events.
JF  - Alcohol Health and Research World
AU  - Roberts, Stephen M
AU  - James, Robert C
AU  - Simmons, Henry F
AU  - Harbison, Raymond D
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 20
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Editor's Forum: Alcohol and Cocaine
AN  - 1474302782
AB  - Research and observations on this deadly combination.
JF  - Alcohol Health and Research World
AU  - Casement, Mary R
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Factors Related to Burnout Among Alcoholism Counselors
AN  - 1474302707
JF  - Alcohol Health and Research World
AU  - BUDRIONIS, M M
AU  - Cunningham, W L
AU  - Pratt, K A
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 82
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Clinical Prevention of Fetal Alcohol Effects - A Reality
AN  - 1474302202
AB  - Evidence for the effectiveness of intervention.
JF  - Alcohol Health and Research World
AU  - Weiner, Lyn
AU  - Larsson, Gunilla
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 60
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Child Care Practices in Alcoholic Families: Findings from a Neighborhood Detoxification Program
AN  - 1474301616
AB  - Gender and number of alcoholic parents change the child care issues.
JF  - Alcohol Health and Research World
AU  - Williams, Carol N
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 74
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Capsule Review of the State of the Art
AN  - 1474301614
AB  - The Sixth Report to Congress on Alcohol and Health.
JF  - Alcohol Health and Research World
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Class Lesson in Alcoholic Malnutrition
AN  - 1474301396
AB  - The poor get sicker than the rich.
JF  - Alcohol Health and Research World
AU  - Moore, Dorothy T
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 58
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - New Studies on the Interaction of Alcohol and Cocaine
AN  - 1474301180
AB  - ADAMHA's program to research physiological effects.
JF  - Alcohol Health and Research World
AU  - Cohn, Victor H
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 26
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Analytical Methods for the Measurement of Tissue Ethanol Levels
AN  - 1474300859
AB  - The science behind the new tests for intoxication.
JF  - Alcohol Health and Research World
AU  - Schaffer, Walter T
AU  - Warren, Kenneth R
Y1  - 1987///Summer
PY  - 1987
DA  - Summer 1987
SP  - 14
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unscheduled DNA synthesis: workshop overview.
AN  - 78061938; 3507249
JF  - Cell biology and toxicology
AU  - Casciano, D A
AD  - Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1987/06//
PY  - 1987
DA  - June 1987
SP  - 109
EP  - 111
VL  - 3
IS  - 2
SN  - 0742-2091, 0742-2091
KW  - Index Medicus
KW  - Animals
KW  - Mutagenicity Tests
KW  - Liver -- metabolism
KW  - DNA Repair
KW  - DNA Damage
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-05-01
N1  - Date created - 1989-05-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - GEN
T1  - Children with Special Health Care Needs. Campaign '87. Surgeon General's Report. Commitment to: Family-Centered, Community-Based, Coordinated Care.
AN  - 63159219; ED291191
AB  - The Surgeon General's report on children with special health needs proposes seven action steps needed to implement a community-based family centered health care approach. Recommended are the following actions: Pledge a national commitment to all children with special health care needs and their families; Encourage building community-based service systems; Assist in ensuring adequate preparation of providers of care; Develop coalitions to improve the delivery of services; Establish guidelines to control costs of services; Encourage and support the development of adequate health care financing; Continue to conduct research and disseminate information. For each action step examples of projects implementing the action are given. The challenge is directed toward families, states, private health care providers, and the health care financing sector in a coordinated effort under the leadership of the Division of Maternal and Child Health. (DB)
Y1  - 1987/06//
PY  - 1987
DA  - June 1987
SP  - 36
PB  - U.S. Department of Health and Human Services, Public Health Service, Health Resources and Services Administration, Bureau of Health Care Delivery and Assistance, Division of Maternal and Child Health, Rockville, MD 20857.
KW  - Child Health Care
KW  - ERIC, Resources in Education (RIE)
KW  - Community
KW  - Costs
KW  - Health Services
KW  - Health Needs
KW  - Research Needs
KW  - Community Programs
KW  - Government Role
KW  - Information Dissemination
KW  - Delivery Systems
KW  - Agency Cooperation
KW  - Special Health Problems
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63159219?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Incidence of Vibrio cholerae from Estuaries of the United States West Coast
AN  - 19034508; 8802871
AB  - The incidence of Vibrio cholerae in shellfish, sediment, and waters of California, Oregon, and Washington was determined during the summer of 1984. Samples from 24 distinct estuaries were analyzed qualitatively. V. cholerae non-O1 was found in 23 estuaries and in 44.6% of the 529 samples examined. V. cholerae O1 Inaba was isolated from water samples in Morro bay, Calif. Vibrio mimicus was found in 2.3% of the samples. Cholera enterotoxin was not found in cell-free filtrates of the 100 isolates tested in the Y-1 mouse adrenal cell assay, but heat-labile cytotoxic activity was observed with 3% of the isolates. (Author 's abstract)
JF  - Applied and Environmental Microbiology AEMIDF Vol. 53, No. 6, p 1344-1348, June 1987. 4 fig, 1 tab, 28 ref.
AU  - Kaysner, CA
AU  - Abeyta, C
AU  - Wekell, M M
AU  - DePaola, A
AU  - Stott, R F
AD  - Food and Drug Administration Seattle, WA. Seafood Products Research Center
Y1  - 1987/06//
PY  - 1987
DA  - Jun 1987
KW  - Water Resources Abstracts
KW  - Water pollution sources
KW  - Path of pollutants
KW  - Estuaries
KW  - Vibrios
KW  - Shellfish
KW  - Sediments
KW  - Pollutant identification
KW  - Isolation
KW  - Natural waters
KW  - Food chain
KW  - Enterotoxins
KW  - Cytotoxicity
KW  - SW 3010:Identification of pollutants
KW  - SW 3020:Sources and fate of pollution
KW  - SW 0890:Estuaries
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Virulent Strains of Vibrio vulnificus Isolated from Estuaries of the United States West Coast
AN  - 19032881; 8802872
AB  - Vibrio vulnificus was isolated from United States West Coast estuaries at a low frequency (5.9%) from 529 samples of water, shellfish, and sediment. Four strains tested with iron-treated mice had 50% lethal dose values ranging from 7.6 to 360 CFU, for a clinical isolate that caused the death of a septicemic patient. The presence of this pathogen may be a hazard to users of marine beaches and consumers of raw shellfish on the West Coast, especially to persons most susceptible to V. vulnificus septicemia. Species-specific antiflagellar serum and a gene probe for cytotoxin-hemolysin production were useful for screening these environmental isolates. (Author 's abstract)
JF  - Applied and Environmental Microbiology AEMIDF Vol. 53, No. 6, p 1349-1351, June 1987. 2 tab, 25 ref.
AU  - Kaysner, CA
AU  - Abeyta, C
AU  - Wekell, M M
AU  - DePaola, A
AU  - Stott, R F
AD  - Food and Drug Administration Seattle, WA. Seafood Products Research Center
Y1  - 1987/06//
PY  - 1987
DA  - Jun 1987
KW  - Water Resources Abstracts
KW  - Water pollution effects
KW  - Bioassay
KW  - Pollutant identification
KW  - Water pollution sources
KW  - Path of pollutants
KW  - Estuaries
KW  - Vibrios
KW  - Shellfish
KW  - Sediments
KW  - Isolation
KW  - Natural waters
KW  - Food chain
KW  - Enterotoxins
KW  - Cytotoxicity
KW  - SW 3010:Identification of pollutants
KW  - SW 3020:Sources and fate of pollution
KW  - SW 0890:Estuaries
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - RPRT
T1  - Setting Nationwide Objectives in Disease Prevention and Health Promotion: The United States Experience. ODPHP Monograph Series.
AN  - 63102558; ED302525
AB  - A description is given of the process of setting nationwide objectives in disease prevention and health promotion. Five national public health goals for enhancing the health of the population at five major life stages are discussed: (1) infant health and mortality reduction; (2) child health and development; (3) health and health habits of adolescents and young adults; (4) improving adult health; and (5) improving health and quality of life for older adults. Priority items are identified within the categories of preventive health services, health protection, and health promotion. The development of these health objectives was undertaken in response to three perceived needs: (1) clarification of national opportunities and intentions; (2) establishment of benchmarks to which federal programs could be addressed; and (3) establishment of a process, national in character, but adaptable to facilitiating the development of local programs. This effort is discussed in the context of the procedural rationale, international experience, and some specific applications. (JD)
Y1  - 1987/05//
PY  - 1987
DA  - May 1987
SP  - 50
KW  - ERIC, Resources in Education (RIE)
KW  - Management by Objectives
KW  - Public Health
KW  - Government Role
KW  - National Programs
KW  - Preventive Medicine
KW  - Public Policy
KW  - Needs Assessment
KW  - Health Education
KW  - Health Promotion
KW  - Disease Control
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63102558?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - Reprint from the "Oxford Textbook of Public Health
N1  - Last updated - 2014-03-21
ER  - 



TY  - BOOK
T1  - Staying healthy: a bibliography of health promotion materials
AN  - 59445925; 1987-2204575
AB  - Currently available materials produced by the Department of Health and Human Services. Consists primarily of public information materials, such as booklets, fact sheets, films, and posters; also includes program guides for professionals and community groups, and some reports on the status of health promotion and disease prevention in the U.S.; lists over 155 new titles and incorporates new subject categories, including acquired immune deficiency syndrome, child abuse, and Medicare.
JF  - Supt Docs, April 1987. i+64 pp.
Y1  - 1987/04//
PY  - 1987
DA  - April 1987
EP  - i+64
PB  - Supt Docs
KW  - Public health education -- Bibliography
KW  - United States -- Health and human services department -- Publications
KW  - Public health -- United States -- Bibliography
KW  - Medicine, Preventive -- Bibliography
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Supt Docs pa $2.25
N1  - Document feature - bibl(s), index(es)
N1  - SuppNotes - 3d ed
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519945034
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519945004
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - RPRT
T1  - Guide to safety in confined spaces.
AN  - 15056292; 1845097
AB  - According to the guide, confined spaces include boilers, cupolas, degreasers, furnaces, pipelines, pits, pumping stations, reaction or process vessels, septic tanks, sewage digesters, sewers silos, storage tanks, ships holds, utility vaults, and vats. A confined space has limited openings for entry and exit, unfavorable natural ventilation, and is not designed for continuous worker occupancy. Hazardous atmospheres that may be present include oxygen difficient atmospheres, flammable atmospheres, or toxic atmospheres. Testing of the atmosphere in the space may be accomplished by using properly calibrated instruments to determine what gases are present at the top, middle, and bottom of the space. If an unfavorable atmosphere exists, ventilation must be performed before entry is made. If ventilation is not possible, adequate personal respiratory protective equipment must be used.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Pettit, T
AU  - Linn, H
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - confined spaces
KW  - Health & Safety Science Abstracts
KW  - ventilation
KW  - occupational safety
KW  - ergonomics
KW  - occupational health
KW  - H SI0.7:HUMAN FACTORS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-130786/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Health hazard evaluation report HETA 87-013-1803, West Seattle Community Hospital, Seattle, Washington.
AN  - 15044334; 1844489
AB  - An evaluation was made in the operating rooms (ORs); the recovery room, and in the OR reception area for nitrous-oxide, ethrane, halothane, and isoflurane. Measurements were also taken for ethylene-oxide (EtO). Of 15 samples taken and tested for NO2, five exceeding the NIOSH Recommended Exposure Limit of 25 parts per million (ppm). Isoflurane was found in all 12 personal and area air samples at concentrations from 0.09 to 1.96 ppm. Ethrane was present in three of 12 samples at concentrations from 0.36 to 0.96ppm. Halothane was below the limit of detection. Isoflurane was detected in a personal sample from the recovery room and in the area sample from the OR reception area at concentrations of 0.69 and 0.65ppm, respectively. Eto levels ranged from 0.02 to 0.11ppm. The authors conclude that a hazard did exist specifically in relation to overexposures to N2O, ethrane, and isoflurane.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Gunter, B J
AU  - Daniels, W J
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - ethane
KW  - ethylene oxide
KW  - isoflurane
KW  - Health & Safety Science Abstracts
KW  - hazards
KW  - nitrous oxide
KW  - air sampling
KW  - hospitals
KW  - H SM1.8.2:CHEMICALS (CORROSION)
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-125984/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Health hazard evaluation report HETA87-043-1801, ACMI Company, Norwalk, Ohio.
AN  - 15036509; 1845394
AB  - A health evaluation was conducted at the ACMI Company (SIC-3841) in Norwalk, Ohio to determine possible causes of an outbreak of dermatitis in workers involved in light carrier assembly. Just prior to the dermatitis outbreak, fibermats were replaced by single optical fibers and production was increased. The sealant used was changed from Loctite-640 to Epo-Tec-377, but dermatitis had been noted before and after the change. During the making of the light carriers, isopropyl-alcohol was used to wet the fibers. A sealant was then applied to make the workpiece water proof. No special methods were taken to prevent contact of the skin with the sealant. Intense and prolonged skin contact with the sealants occurred as a matter of course during the assembly. The investigators concluded that the skin problems were caused by contact with resins.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Laubli, T
AU  - Mathias, CGT
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - dermatitis
KW  - Ohio, Norwalk
KW  - Health & Safety Science Abstracts
KW  - occupational health
KW  - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-126131/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Health hazard evaluation report HETA 86-269-1812, Federal Reserve Bank, Cincinnati, Ohio.
AN  - 15008819; 1818240
AB  - In response to a request from the Federal Reserve Bank (SIC-6011) located in Cincinnati, Ohio, an evaluation of airborne lead (7439921) exposures was made during the use of an indoor firing range. The range was used by about 20 bank guards who must qualify quarterly; range officers were rotated to reduce chronic exposures. Lead levels produced by the firing of two specific types of ammunition was also evaluated. The lead level exceeded OSHA permissible exposure limit of 50 micro g/m3. During evaluations the ventilation system at the range was performing poorly. Airflow was erratic and turbulent so that much of the air flowed backwards. The cooper coating on the bullets was apparently too thin to do much to stop the lead from entering the atmosphere. The author concludes that a health hazard from over exposure to lead existed at the firing range.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Lee, SA
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - Ohio, Cincinnati
KW  - pollutant detection
KW  - Pollution Abstracts
KW  - lead
KW  - air pollution
KW  - P 0000:AIR POLLUTION
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Lee%2C+SA&rft.aulast=Lee&rft.aufirst=SA&rft.date=1987-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+hazard+evaluation+report+HETA+86-269-1812%2C+Federal+Reserve+Bank%2C+Cincinnati%2C+Ohio.&rft.title=Health+hazard+evaluation+report+HETA+86-269-1812%2C+Federal+Reserve+Bank%2C+Cincinnati%2C+Ohio.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-153226/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - In-depth survey report: Control technology for asbestos removal at Bloom Middle School, Cincinnati, Ohio.
AN  - 14973558; 1799472
AB  - The effectiveness of various controls used by the asbestos abatement industry to control asbestos contamination at its source was evaluated. The glove bag control method to prevent exposure in workplaces was used during the removal of asbestos pipe lagging from the Bloom Middle School, Cincinnati, Ohio by I and F Corporation. The removal contract required about 1,800 linear feet of asbestos pipe lagging to be removed from 15 major rooms and areas of the building. General operation included initial site clean up, clearance of all movable materials, and site isolation by sealing off all access with plastic sheeting taped to windows, air vents, and doors.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Hollett, BA
AU  - Caplan, P E
AU  - Cooper, T C
AU  - Froehlich, P A
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - Ohio, Cincinnati
KW  - Pollution Abstracts
KW  - asbestos
KW  - surveys
KW  - contamination
KW  - pollution control
KW  - P 9000:ENVIRONMENTAL ACTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-189451/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Fatal Accident Circumstances and Epidemiology (FACE) report: Worker dies inside filtration tank in Michigan, May 12, 1987.
AN  - 14971572; 1795031
AB  - A 55 year old city worker with 25 years experience died while checking the inside of an empty, open top concrete filtration tank at a sewage treatment facility. The tank was 15 feet wide by 24 feet long and 12 feet deep. The facility had regular safety procedures, safety education for employees, and necessary testing equipment for confined space atmospheric analysis along with several self contained breathing apparatus units. No specific training was offered on confined space entry. The victim's task was to inspect the depth of filter media in all 12 filter tanks. He had completed six tanks 4 days prior to the accident.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - FACE-87-47
KW  - occupational health
KW  - accidents
KW  - filtration
KW  - mortality
KW  - sewage treatment plants
KW  - P 3000:SEWAGE & WASTEWATER TREATMENT
KW  - H SE3.4:ACCIDENT INVESTIGATION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-190236/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Fatal Accident Circumstances and Epidemiology (FACE) report: 32 year-old electrician electrocuted in Georgia, August 12, 1986.
AN  - 14971172; 1795059
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - electrocution
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - accidents
KW  - electricity
KW  - H SI10.4:ACCIDENT INVESTIGATION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14971172?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-190228/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - NIOSH (National Institute for Occupational Safety and Health) indoor air quality in office buildings.
AN  - 14753963; 1613588
AB  - A total of 356 indoor air quality health hazard evaluations were completed by NIOSH from 1971 through December of 1985. Most of these studies concerned government and private office buildings where there were worker complaints. Worker complaints resulted from contamination from inside the building (19 percent of the cases), contamination from outside (11 percent), contamination from the building fabric (4 percent), biological contamination (5 percent), inadequate ventilation (50 percent), and unknown causes (11 percent). Health complaints which were addressed by investigative efforts included eye irritation, dry throat, headache, fatigue, sinus congestion, skin irritation, shortness of breath, cough, dizziness, and nausea.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Wallingford, K M
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - Tight Building Syndrome
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational safety
KW  - occupational health
KW  - ventilation
KW  - air quality
KW  - buildings
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - H SI1.8.2:CHEMICALS (CORROSION)
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14753963?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Wallingford%2C+K+M&rft.aulast=Wallingford&rft.aufirst=K&rft.date=1987-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NIOSH+%28National+Institute+for+Occupational+Safety+and+Health%29+indoor+air+quality+in+office+buildings.&rft.title=NIOSH+%28National+Institute+for+Occupational+Safety+and+Health%29+indoor+air+quality+in+office+buildings.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB87-174397/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Registry of toxic effects of chemical substances (RTECS), 1986 edition. User's guide to the RTECS computer tape.
AN  - 14748494; 1613394
AB  - The 1986 edition of the Registry of Toxic Effects of Chemical Substances (RTECS), formerly known as the Toxic Substances List, is the fifteenth annual revision prepared in compliance with the requirements of Section 20(a)(6) of the Occupational Safety and Health Act of 1970 (Public Law 91-596). The original list was completed on June 28, 1971, and has been updated annually in book format. Beginning in 1977, computer tapes of the complete RTECS file have also been provided. In 1986, these tapes were provided quarterly, in January, April, July, and October. The 1986 edition of the RTECS computer tape, which was issued in January 1987, contains 86,969 substance entries and supersedes all previous RTECS tape editions. A complete description of the various types of data in the RTECS file is contained in the Detailed File Description. The user is strongly encouraged to read this material before processing the data, since the data should not be used until the limitations of the RTECS file regarding data validity, completeness, and applicability are understood.
JF  - NTIS, SPRINGFIELD, VA (USA). 1987.
AU  - Sweet, D V
Y1  - 1987/04//
PY  - 1987
DA  - Apr 1987
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - toxic materials
KW  - chemicals
KW  - data bases
KW  - public health
KW  - H SM3.2:DATA ANALYSIS
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB87-171682/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Traditional and Nontraditional Homeless Alcoholics
AN  - 1474330123
AB  - Findings from Los Angeles' skid row.
JF  - Alcohol Health and Research World
AU  - Koegel, Paul
AU  - Burnam, M Audrey
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Old Town Portland and an Oldtime Problem
AN  - 1474330069
AB  - How a citizens' group is confronting alcoholism and homelessness on skid row.
JF  - Alcohol Health and Research World
AU  - Newton, Stephen P
AU  - Duffy, Charles P
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 62
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Homelessness as a Health Risk
AN  - 1474329970
AB  - Analysis of self-reported physical and mental health status.
JF  - Alcohol Health and Research World
AU  - Ropers, Richard H
AU  - Boyer, Richard
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 38
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Client Tracking System: A Tool for Studying the Homeless
AN  - 1474328634
AB  - Using computer technology to generate service delivery data on the homeless.
JF  - Alcohol Health and Research World
AU  - Kline, Michael V
AU  - Bacon, John D
AU  - Chinkin, Morris
AU  - Manov, William F
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 66
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Readers' Exchange: The Alcoholic's Moral Dilemma
AN  - 1474326758
JF  - Alcohol Health and Research World
AU  - Bickerton, Dick
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 84
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Nonmedical Treatment of Indigent Alcoholics: A Review of Recent Research Findings
AN  - 1474326127
AB  - Social setting treatment as an alternative to medical model rehabilitation.
JF  - Alcohol Health and Research World
AU  - Sadd, Susan
AU  - Young, Douglas W
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 15: Demographic Trends, Alcohol Abuse and Alcoholism, 1985-1995
AN  - 1474326108
JF  - Alcohol Health and Research World
AU  - Williams, Gerald D
AU  - Stinson, Frederick S
AU  - Parker, Douglas A
AU  - Harford, Thomas C
AU  - Noble, John
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 80
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - NIMH Initiatives for the Homeless Mentally Ill
AN  - 1474325047
AB  - Research support and demonstration projects addressing the dual dilemma.
JF  - Alcohol Health and Research World
AU  - Shifren Levine, Irene
AU  - Haggard, Loretta
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol, Architecture, and Homelessness
AN  - 1474324636
AB  - Physical environment - more than bricks and mortar.
JF  - Alcohol Health and Research World
AU  - WITTMAN, FRIEDNER D
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 74
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Profile of the Baltimore Homeless with Alcohol Problems
AN  - 1474324138
AB  - Preliminary results of a citywide clinical study.
JF  - Alcohol Health and Research World
AU  - Fischer, Pamela J
AU  - Breakey, William R
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 36
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Program Planning for Alcohol-Free Living Centers
AN  - 1474323735
AB  - An approach to unhinging the "revolving door."
JF  - Alcohol Health and Research World
AU  - Korenbaum, Sue
AU  - Burney, Gina
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 68
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Salvation and Sobriety
AN  - 1474323631
AB  - The Salvation Army's determined assault on skid row problems.
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 14
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Ailments and Alcohol: Health Status Among the Drinking Homeless
AN  - 1474323613
AB  - Results from a nationwide clinical data base.
JF  - Alcohol Health and Research World
AU  - Wright, James D
AU  - Knight, Janet W
AU  - Weber-Burdin, Eleanor
AU  - Lam, Julie
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 22
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474302900
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 86
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Networking by the Homeless Alcoholic Profile of Failure/Profile of Success How Should Shelters Respond to Alcohol-Related Violence?
AN  - 1474302788
AB  - Front-line workers pose some tough questions about alcohol and the homeless.
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 58
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - New Focus for an Old Problem: Philadelphia's Response to Homelessness
AN  - 1474302785
AB  - "A philosophy that denies losing."
JF  - Alcohol Health and Research World
AU  - Shandler, Irving W
AU  - Shipley, Thomas E
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 54
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - News Notes
AN  - 1474302784
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 86
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Occupational Arena
AN  - 1474302691
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 88
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Treating the Homeless
AN  - 1474302560
AB  - Holistic strategies for the "old" and "new" homeless client.
JF  - Alcohol Health and Research World
AU  - Breakey, William R
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 42
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Editor's Forum: The Epidemiology of Alcohol-Related Problems Among the Homeless
AN  - 1474302416
AB  - New feature provides indepth look at a timely issue.
JF  - Alcohol Health and Research World
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 20
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol-Related Problems Among the Homeless: NIAAA's Response
AN  - 1474302358
AB  - Mobilizing resources to confront a persistent crisis.
JF  - Alcohol Health and Research World
AU  - LUBRAN, BARBARA G
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Century of Alcohol and Homelessness: Demographics and Stereotypes
AN  - 1474302167
AB  - Surprising consistencies in research findings since the 1890's.
JF  - Alcohol Health and Research World
AU  - Stark, Louisa
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 8
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Social Services for Homeless Alcoholics: Assessment and Response
AN  - 1474301602
AB  - Enhancing case management and service planning in Boston's Long Island Shelter Project.
JF  - Alcohol Health and Research World
AU  - Garrett, Gerald R
AU  - Schutt, Russell K
Y1  - 1987///Spring
PY  - 1987
DA  - Spring 1987
SP  - 50
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Neurobehavioral effects of the calcium ionophore A23187.
AN  - 81035983; 3116383
AB  - The divalent cationic ionophore A23187 (calimycin) facilitates the transport of calcium ions across biological membranes, resulting in an increase of cytosolic calcium. A23187 has been used extensively in vitro to activate calcium-dependent neurocellular processes. Because of its potential usefulness as a neurotoxicological probe, our laboratory conducted a series of studies to characterize the neurofunctional consequences of A23187 in the intact organism. In addition to approximating the LD50, the effects of acute parenteral administration of A23187 on conditioned avoidance, nociceptive shock threshold, open-field activity, consummatory behavior, body temperature and neuromotor function, including general activity, coordination, balance and grip strength, were assessed in the rodent. The LD50 of A23187, administered intraperitoneally to adult male rats, was 9.2 mg/kg. The predominant overt signs of toxicity included lethargy, limb weakness and apnea. Lower doses, from 0.5 to 0.03 mg/kg, produced a variety of more subtle neurobehavioral effects, including a selective depression of motor activity, a moderate elevation of shock threshold, altered conditioned avoidance behavior and hypothermia.
JF  - Neurotoxicology and teratology
AU  - Sobotka, T J
AU  - Brodie, R E
AU  - Quander, Y
AU  - O'Donnell, M
AU  - West, G L
AD  - Division of Toxicology, Food and Drug Administration, Washington, DC 20204.
PY  - 1987
SP  - 99
EP  - 106
VL  - 9
IS  - 2
SN  - 0892-0362, 0892-0362
KW  - Calcimycin
KW  - 37H9VM9WZL
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Injections, Intraperitoneal
KW  - Animals
KW  - Body Temperature -- drug effects
KW  - Exploratory Behavior -- drug effects
KW  - Lethal Dose 50
KW  - Motor Activity -- drug effects
KW  - Avoidance Learning -- drug effects
KW  - Time Factors
KW  - Male
KW  - Nociceptors -- drug effects
KW  - Behavior, Animal -- drug effects
KW  - Nervous System -- drug effects
KW  - Calcimycin -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-05
N1  - Date created - 1987-11-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Evaluation of Immunotoxicity in a Subchronic Feeding Study of Triphenyl Phosphate
AN  - 760216120; 13641382
AB  - Triphenyl phosphate (TPP), a potential food contaminant, was fed to weanling Spartan Sprague-Dawley rats at dose levels of 0, 0.25, 0.5, 0.75, and 1.0%for 120 days. The immunotoxicity evaluation, planned as a minimum testing model in a subchronic study design as well as to provide information on TPP, was performed along with the routine testing of a separate group of animals. Traditional measures were made of growth and food consumption, total pro tein analysis, electrophoretic analyses of serum proteins, lymphoid organ weights in relation to growth, and histopathology, with expanded immunohistochemical evaluation of B- and T- lymphocyte regions in spleen, thymus, and lymph nodes, using immunoperoxidase staining. Assessment was made of the humoral response to a T-lymphocyte-dependent antigen, sheep red blood cells, and was begun at midterm of the feeding period for the pri mary response followed by secondary and teritary booster immuni zations at 3-week intervals. The kinetics of the responses were measured by hemolysin assay of relative antibody titers at days 3, 4, 5, and 6 postinjection. No significant effects on the responses were noted for either sex at any of the dose levels tested. The only effects noted were a decreased rate of growth at high levels of TPP and increases in the levels of a- and b-globulins suggestive of increased hepatic activity.
JF  - Toxicology and Industrial Health
AU  - Hinton, Dennis M
AU  - Jessop, John J
AU  - Arnold, Alphonso
AU  - Albert, Richard H
AU  - Hines, Fred A
AD  - Division of Toxicology Center for Food Safety and Applied Nutrition Food and Drug Administration Washington, D.C
Y1  - 1987/03//
PY  - 1987
DA  - Mar 1987
SP  - 71
EP  - 89
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 3
IS  - 1
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts; Immunology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts
KW  - feeding
KW  - Histopathology
KW  - Lymphocytes
KW  - Serum proteins
KW  - Rats
KW  - Food consumption
KW  - immunotoxicity
KW  - Immune response (humoral)
KW  - Hemolysins
KW  - Sex
KW  - Feeding
KW  - Sheep red blood cells
KW  - Thymus
KW  - Spleen
KW  - Food contamination
KW  - Organs
KW  - Lymph nodes
KW  - Antibodies
KW  - Immunotoxicity
KW  - Phosphates
KW  - Phosphate
KW  - Kinetics
KW  - Liver
KW  - Proteins
KW  - F 06955:Immunomodulation & Immunopharmacology
KW  - H 1000:Occupational Safety and Health
KW  - X 24350:Industrial Chemicals
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 31
N1  - Last updated - 2015-03-19
N1  - SubjectsTermNotLitGenreText - Feeding; Sheep red blood cells; Thymus; Spleen; Food contamination; Lymph nodes; Serum proteins; Food consumption; Immunotoxicity; Antibodies; Phosphate; Kinetics; Liver; Immune response (humoral); Hemolysins; Sex; Rats; Phosphates; feeding; Proteins; Histopathology; Lymphocytes; immunotoxicity; Organs
DO  - http://dx.doi.org/10.1177/074823378700300103
ER  - 



TY  - JOUR
T1  - Health-Risk Estimates for 2,3,7,8-Tetrachlorodibenzodioxin: an Overview
AN  - 760214888; 13641383
AB  - Abstract not available.
JF  - Toxicology and Industrial Health
AU  - Fishbein, Lawrence
AD  - National Center for Toxicological Research Jefferson, Arkansas
Y1  - 1987/03//
PY  - 1987
DA  - Mar 1987
SP  - 91
EP  - 134
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 3
IS  - 1
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - Reviews
KW  - X 24350:Industrial Chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 149
N1  - Last updated - 2015-03-19
N1  - SubjectsTermNotLitGenreText - Reviews
DO  - http://dx.doi.org/10.1177/074823378700300104
ER  - 



TY  - GEN
T1  - AIDS: Information/Education Plan to Prevent and Control AIDS in the United States.
AN  - 63244679; ED281078
AB  - This document presents a comprehensive Public Health Service plan for informing and educating the American public about Acquired Immune Deficiency Syndrome (AIDS). The plan specifies the audiences to be addressed by this effort, the basic elements of AIDS information and education, and the means by which this education will be accomplished. Mass media campaigns, health education programs, demonstration programs, a clearinghouse of AIDS information, critical agency cooperation, and the development of special information for use by educators are discussed. Part I of this report, Overview, contains an introduction and sections on planning, implementation, evaluation, and a time table. Part II presents basic elements of AIDS information. Part III, Components of the Plan, presents an action matrix and action steps for each of the four major information/education effort components: (1) the public; (2) school and college aged populations; (3) persons at increased risk or infected; and (4) health workers. Part IV contains appendices of accomplishments through 1986, a list of Public Health Service available materials, and a glossary of abbreviations for federal organizations. (NB)
Y1  - 1987/03//
PY  - 1987
DA  - March 1987
SP  - 60
KW  - ERIC, Resources in Education (RIE)
KW  - Prevention
KW  - Public Health
KW  - High Risk Persons
KW  - Information Dissemination
KW  - Acquired Immunodeficiency Syndrome
KW  - Public Education
KW  - Educational Planning
KW  - Mass Media
KW  - Disease Control
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63244679?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Assessing the feasibility of retrospective cohort studies.
AN  - 81096551; 3674029
AB  - While most epidemiologic cohort studies are preceded by some sort of feasibility study, details of such prior investigations are rarely reported. Yet it is during such feasibility studies that critical decisions are made, such as site selection and definition of exposure. Here we present the details on one such feasibility study, conducted to determine the possibility of a cohort mortality study of workers exposed to ethylene oxide. Issues discussed include methods for estimating sample size and power, for estimating levels of exposure, and for assessing the adequacy of personnel records.
JF  - American journal of industrial medicine
AU  - Steenland, K
AU  - Stayner, L
AU  - Greife, A
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 419
EP  - 430
VL  - 12
IS  - 4
SN  - 0271-3586, 0271-3586
KW  - Ethylene Oxide
KW  - JJH7GNN18P
KW  - Index Medicus
KW  - Feasibility Studies
KW  - Leukemia -- chemically induced
KW  - Leukemia -- mortality
KW  - Humans
KW  - Ethylene Oxide -- adverse effects
KW  - Records as Topic
KW  - Data Collection
KW  - Retrospective Studies
KW  - Occupational Diseases -- chemically induced
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-04
N1  - Date created - 1987-12-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Human poisoning by zigadenus.
AN  - 81075779; 3669121
AB  - Zigadenus (death camas) is a dangerous plant in the United States. The literature contains several well-documented nonfatal human cases of zigadenus poisoning. Fatal cases were recorded in interviews of 19th century western American Indians. This paper contains an account from early in the 20th century of some railroad workers who died shortly after eating the bulbs. The probable fatal dose, extrapolated from animal data, ranges from less than one-tenth pound (four-five bulbs) for a young child to a pound for an adult. Other parts of the plant such as nectar and seeds are also highly toxic.
JF  - Journal of toxicology. Clinical toxicology
AU  - Wagstaff, D J
AU  - Case, A A
AD  - Epidemiology and Clinical Toxicology Unit, Food and Drug Administration, Washington, DC 20204.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 361
EP  - 367
VL  - 25
IS  - 4
SN  - 0731-3810, 0731-3810
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Animals
KW  - Indians, North American
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Adult
KW  - Child
KW  - Plants, Toxic
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-12-16
N1  - Date created - 1987-12-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice.
AN  - 81074873; 3669095
AB  - In order to evaluate the influence of age on 2-acetylaminofluorene (2-AAF) carcinogenesis, female BALB/c mice were fed diets containing 500 ppm 2-AAF for 6 mo, starting at 1, 7, or 13 mo of age. Groups of mice were killed immediately, 3 or 6 mo after termination of treatment, or were allowed to complete their life span. Mice corresponding to the age of each sacrifice group of the 2-AAF-treated mice and a life-span group were also included as controls. The study was moved to a different animal room area after 25 wk into the study. Thus, certain treatment groups were replicated to evaluate the impact of the change in environment. Controls and the young 2-AAF-treatment group killed at 7 mo of age were replicated twice in the new animal room at 6-mo intervals. Similarly, controls and the mid-aged treatment group killed at 13 mo of age were repeated once in the new animal room. This resulted in mice of each age/treatment group being treated simultaneously in the same room and killed as soon as treatment was stopped. The main histopathologic responses to 2-AAF were observed in the urinary bladder, liver, and mammary glands. In all three replicates urinary bladder hyperplasia was less severe when young mice were treated than when mid-aged or old mice were treated. In contrast, there was no clear influence of age on bladder tumorigenesis, although replicate variation in this response was very great. Tentatively one also may conclude that (1) sensitivity to the induction of mammary tumorigenesis by 2-AAF increased with the age of mice at the time of treatment, and (2) old mice were sensitive to induction of liver karyomegaly and cytoplasmic and nuclear inclusions, while young and mid-aged mice were resistant to this influence. Perhaps the most important conclusion to be made from this study is that replicate variation, probably due to environmental factors, may result in false conclusions concerning age sensitivity to a carcinogen if differing age groups are not treated simultaneously and/or key parts of an experiment are not replicated to eliminate the possibility of an influence of environmental factors or nonrandom assignment of animals to age groups.
JF  - Journal of toxicology and environmental health
AU  - Greenman, D L
AU  - Boothe, A
AU  - Kodell, R
AD  - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 113
EP  - 129
VL  - 22
IS  - 2
SN  - 0098-4108, 0098-4108
KW  - 2-Acetylaminofluorene
KW  - 9M98QLJ2DL
KW  - Index Medicus
KW  - Environment
KW  - Mammary Neoplasms, Experimental -- chemically induced
KW  - Animals
KW  - Uterine Neoplasms -- chemically induced
KW  - Body Weight -- drug effects
KW  - Liver Neoplasms -- chemically induced
KW  - Liver Neoplasms, Experimental -- chemically induced
KW  - Mice
KW  - Lung Neoplasms -- chemically induced
KW  - Female
KW  - Urinary Bladder Neoplasms -- chemically induced
KW  - Mice, Inbred BALB C -- physiology
KW  - 2-Acetylaminofluorene -- pharmacology
KW  - Neoplasms, Experimental -- chemically induced
KW  - Aging
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-24
N1  - Date created - 1987-11-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Occupational asthma from inhaled egg protein.
AN  - 81048409; 3661573
AB  - We evaluated workers and performed an industrial hygiene assessment at a plant where raw eggs are processed into powdered egg yolk and whole egg. Egg dust levels in the packaging room straddled the American Conference of Governmental Industrial Hygienists' (ACGIH) exposure guideline of 10 mg/m3 for nuisance dust. We obtained medical histories from 25 workers, and performed physical examinations, spirometry, and serial determinations of peak expiratory flow rate (PEFR) by portable meter every 3 hrs (while awake) for 7 days. We defined symptomatic bronchial lability to be a decrement in PEFR on any one day of 20% or more of the day's maximum, with concurrent symptoms. Skin-prick tests and serum assays for specific IgE by the radioallergosorbent (RAST) method were performed to assess sensitivity to commercial egg proteins, egg protein fractions, and freshly prepared extracts of whole egg powder and yolk. We classified participants as definite cases of asthma if both the examining physician diagnosed asthma and symptomatic bronchial lability was demonstrated by serial PEFR determinations. Definite noncases of asthma were those participants in whom the physician did not diagnose asthma and in whom symptomatic bronchial lability was not demonstrated by PEFR. All five definite cases, compared to three of 16 definite noncases of asthma, had one or more positive skin-prick tests to egg proteins. Four of five cases, compared to 0 of 14 noncases, who had serum determinations, had an elevated RAST to one or more of the egg proteins. This study demonstrates that occupational asthma associated with IgE-mediated allergy to egg proteins occurs among workers exposed to inhaled egg proteins.
JF  - American journal of industrial medicine
AU  - Smith, A B
AU  - Bernstein, D I
AU  - Aw, T C
AU  - Gallagher, J S
AU  - London, M
AU  - Kopp, S
AU  - Carson, G A
AD  - Hazard Evaluation and Technical Assistance Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 205
EP  - 218
VL  - 12
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Egg Proteins
KW  - Index Medicus
KW  - Radioallergosorbent Test
KW  - Peak Expiratory Flow Rate
KW  - Skin Tests
KW  - Humans
KW  - Male
KW  - Occupational Diseases -- immunology
KW  - Egg Proteins -- adverse effects
KW  - Air Pollutants, Occupational -- adverse effects
KW  - Occupational Diseases -- physiopathology
KW  - Asthma -- chemically induced
KW  - Occupational Diseases -- chemically induced
KW  - Asthma -- physiopathology
KW  - Asthma -- immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1987-11-19
N1  - Date created - 1987-11-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Erratum In:
Am J Med 1988;13(4):527
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - The regulation of herpes simplex virus-specific CTL induction by suppressor cells.
AN  - 78084753; 2855699
AB  - The incubation of herpes simplex virus (HSV) immune murine splenocytes with HSV antigens induced suppressor cells which inhibited HSV-specific cytotoxic T lymphocyte (CTL) induction. The cell mediating the suppression was identified as a Thy 1+ Lyt 2+ I-J+ cell. The induction of this suppressor cell required the participation of at least three leukocyte populations. That is, depleting the cultures of either Lyt 1+ or Lyt 2+ splenocytes resulted in a failure to induce suppressor cell activity. Likewise the removal of macrophage-like antigen-presenting cells (APC), in particular I-A- I-J+ APC, abolished suppressor-cell induction. Though the Lyt 2+ I-J+ cells had to be provided by HSV-immune mice, both the APC and the Lyt 1+ cells could be provided by HSV-naive mice. Though the induction of the suppressor cell was virus specific, its action was nonspecific as evidenced by the suppression of influenza-specific CTL induction. The implication of our results for the understanding and manipulation of herpesvirus disease is briefly discussed.
JF  - Viral immunology
AU  - Horohov, D W
AU  - Moore, R N
AU  - Rouse, B T
AD  - Center for Drugs and Biologics, Division of Virology, Food and Drug Administration, Bethesda, MD 20892.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 55
EP  - 68
VL  - 1
IS  - 1
SN  - 0882-8245, 0882-8245
KW  - Antigens, Viral
KW  - 0
KW  - Cyclophosphamide
KW  - 8N3DW7272P
KW  - Index Medicus
KW  - Animals
KW  - Spleen -- cytology
KW  - Antigens, Viral -- immunology
KW  - Mice, Inbred C3H
KW  - Cyclophosphamide -- metabolism
KW  - Mice
KW  - T-Lymphocytes, Cytotoxic -- immunology
KW  - Simplexvirus -- immunology
KW  - T-Lymphocytes, Regulatory -- immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-10-20
N1  - Date created - 1989-10-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Structure-activity relationships in the threshold assessment.
AN  - 78022985; 3330520
JF  - Drug metabolism reviews
AU  - Benson, R
AD  - Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20857.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 331
EP  - 343
VL  - 18
IS  - 2-3
SN  - 0360-2532, 0360-2532
KW  - Index Medicus
KW  - Drug Evaluation
KW  - Animals
KW  - Maximum Allowable Concentration
KW  - Environmental Exposure
KW  - Structure-Activity Relationship
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-07-26
N1  - Date created - 1988-07-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Regulatory roles of high-affinity metal-binding proteins in mediating lead effects on delta-aminolevulinic acid dehydratase.
AN  - 77988518; 3442387
AB  - The present series of studies demonstrate that several high-affinity metal-binding proteins regulate essential metal availability and play a role in metal detoxication. Rat kidney PbBP and ZnMT were shown to mediate both the interaction of Zn and Pb to a Zn metalloenzyme, that is, ALAD. The mechanism for this interaction involves the donation of Zn from PbBP and ZnMT to ALAD and chelation of Pb to these proteins. In addition to activating ALAD via donation of Zn from ZnMT to the enzyme, kidney apothionein was shown to deactivate ALAD. Thus, these proteins may provide an intracellular reservoir for essential metals such as Zn and Cu, serving as a homeostatic control mechanism to readily dispense and sequester these cations to meet cellular metabolic requirements, such as the regulation of metalloenzymes, including ALAD. Although Pb does not effectively induce the synthesis of PbBP or ZnMT, these proteins, via binding of Pb, alter the biological activity of Pb toward a highly sensitive target molecule for Pb, that is, ALAD. Finally, when ALAD is utilized as a biological indicator for Pb exposure, the effect of ZnMT on Pb availability and ALAD activity must be taken into consideration. Tissue-specific differences in these high-affinity, metal-binding proteins and Zn status may alter the expected relationships between total tissue Pb concentrations and inhibition of ALAD.
JF  - Annals of the New York Academy of Sciences
AU  - Goering, P L
AU  - Fowler, B A
AD  - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 235
EP  - 247
VL  - 514
SN  - 0077-8923, 0077-8923
KW  - Carrier Proteins
KW  - 0
KW  - lead-binding proteins
KW  - zinc thionein
KW  - Lead
KW  - 2P299V784P
KW  - Copper
KW  - 789U1901C5
KW  - Metallothionein
KW  - 9038-94-2
KW  - Porphobilinogen Synthase
KW  - EC 4.2.1.24
KW  - Zinc
KW  - J41CSQ7QDS
KW  - Index Medicus
KW  - Rats
KW  - Brain -- enzymology
KW  - Animals
KW  - Liver -- enzymology
KW  - Cattle
KW  - Liver -- drug effects
KW  - Brain -- drug effects
KW  - Copper -- metabolism
KW  - Zinc -- metabolism
KW  - Kidney -- enzymology
KW  - Kidney -- drug effects
KW  - Carrier Proteins -- metabolism
KW  - Lead -- toxicity
KW  - Porphobilinogen Synthase -- metabolism
KW  - Lead -- metabolism
KW  - Metallothionein -- metabolism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Regulatory+roles+of+high-affinity+metal-binding+proteins+in+mediating+lead+effects+on+delta-aminolevulinic+acid+dehydratase.&rft.au=Goering%2C+P+L%3BFowler%2C+B+A&rft.aulast=Goering&rft.aufirst=P&rft.date=1987-01-01&rft.volume=514&rft.issue=&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-20
N1  - Date created - 1988-04-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Quantifying risk and accuracy in cancer risk assessment: the process and its role in risk management problem-solving.
AN  - 77959885; 3326978
AB  - A better understanding of chemical-induced cancer has led to appreciation of similarities to problems addressed by risk management of radiation-induced toxicity. Techniques developed for cancer risk assessment of toxic substances can be generalized to toxic agents. A recent problem-solving approach for risk management of toxic substances developed for the U.S. Department of Health and Human Services, and the role of risk assessment and how uncertainty should be treated within the context of this approach, is discussed. Finally, two different methods, research into the assumptions underlying risk assessment and the modification of risk assessment/risk management documents, are used to illustrate how the technique can be applied.
JF  - Medical oncology and tumor pharmacotherapy
AU  - Turturro, A
AU  - Hart, R W
AD  - National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 125
EP  - 132
VL  - 4
IS  - 3-4
SN  - 0736-0118, 0736-0118
KW  - Index Medicus
KW  - Risk Factors
KW  - Humans
KW  - Neoplasms -- chemically induced
KW  - Neoplasms -- epidemiology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+oncology+and+tumor+pharmacotherapy&rft.atitle=Quantifying+risk+and+accuracy+in+cancer+risk+assessment%3A+the+process+and+its+role+in+risk+management+problem-solving.&rft.au=Turturro%2C+A%3BHart%2C+R+W&rft.aulast=Turturro&rft.aufirst=A&rft.date=1987-01-01&rft.volume=4&rft.issue=3-4&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Medical+oncology+and+tumor+pharmacotherapy&rft.issn=07360118&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-04-21
N1  - Date created - 1988-04-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - In vitro embryotoxic effects of ethylene glycol in rats.
AN  - 77926307; 2893462
AB  - Rat embryos of the CD strain were treated in a whole embryo culture system with either 30 or 40 microliters of ethylene glycol (EG) per milliliter of culture medium for the first 8 (0-8 hr) or second 8 (8-16 hr) hr of a 48-hr culture period. The compound was not embryolethal under these conditions but did alter growth and development. EG at 40 microliters/ml of culture medium at 8-16 hr decreased morphological score, somite number, crown-rump and head lengths, as well as DNA and protein contents. The most frequent abnormality induced by the compound was absence of yolk sac circulation; absent hindlimb bud, hypoplastic telencephalon, and lack of development of the otic and optic systems were also seen in EG-exposed embryos. Since it has been reported that rodent embryos cultured in vitro lack alcohol and aldehyde dehydrogenases that metabolize EG, present results suggest that the parent compound is capable of altering normal embryonic development when administered during a brief period or organogenesis.
JF  - Teratogenesis, carcinogenesis, and mutagenesis
AU  - Grafton, T F
AU  - Hansen, D K
AD  - Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 483
EP  - 489
VL  - 7
IS  - 5
SN  - 0270-3211, 0270-3211
KW  - Ethylene Glycols
KW  - 0
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - In Vitro Techniques
KW  - Time Factors
KW  - Ethylene Glycols -- toxicity
KW  - Embryo, Mammalian -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-03-04
N1  - Date created - 1988-03-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Mitomycin C-induced sister chromatid exchanges in vivo and in vivo/in vitro in mice and Chinese hamsters.
AN  - 77878467; 3121309
AB  - Mouse and Chinese hamster models have been extensively used for assessing the cytogenetic effects of environmental carcinogens and mutagens. However, there is little information on comparative analysis of chromosomal damage in these species under in vivo and in vivo/in vitro (culturing of cells from animals exposed to the test compound) systems. To obtain such information, mice and Chinese hamsters were injected with varying concentrations (0.5-6.0 mg/kg) of mitomycin C, an antineoplastic drug. The bone marrow and spleen cells were analyzed for the number of sister chromatid exchanges (SCEs) under in vivo and in vivo/in vitro conditions. The results indicated a dose-related SCE response that varied with species, tissues, and assay conditions. The mouse cells appeared more sensitive to the effects of mitomycin C than did Chinese hamster cells. In general, the SCE frequencies were relatively higher under in vivo conditions than under in vivo/in vitro conditions in both species. The spleen cells had higher SCE values than bone marrow cells under in vivo/in vitro conditions in both species. These differences may be related to the pharmacokinetic properties of the drug in different species and tissues, to treatment conditions, or to the repair capabilities of the cells. This study also indicates the usefulness of recently established bone marrow and spleen in vivo/in vitro cell cultures for comparative cytogenetic analysis.
JF  - Environmental and molecular mutagenesis
AU  - Krishna, G
AU  - Nath, J
AU  - Ong, T
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 157
EP  - 167
VL  - 10
IS  - 2
SN  - 0893-6692, 0893-6692
KW  - Mitomycins
KW  - 0
KW  - Mitomycin
KW  - 50SG953SK6
KW  - Index Medicus
KW  - Animals
KW  - Mutagenicity Tests
KW  - Cricetulus
KW  - Cells, Cultured
KW  - Organ Specificity
KW  - Mice
KW  - Spleen -- drug effects
KW  - Species Specificity
KW  - Bone Marrow -- drug effects
KW  - Male
KW  - Cricetinae
KW  - Sister Chromatid Exchange -- drug effects
KW  - Mitomycins -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-16
N1  - Date created - 1988-02-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Modulation of ultraviolet light-, ethyl methanesulfonate-, and 7,12-dimethylbenz[a]anthracene-induced unscheduled DNA synthesis by retinol and retinoic acid in the primary rat hepatocyte.
AN  - 77867329; 3121308
AB  - The effects of retinol and retinoic acid on unscheduled DNA synthesis (UDS) in primary Sprague-Dawley rat hepatocytes were studied in the presence and absence of known chemical and physical mutagens. Neither retinol nor retinoic acid caused a significant increase in UDS over solvent control at concentrations ranging from 1 microM to 50 microM. Retinol and retinoic acid did not significantly affect 200 micrograms/mL ethyl methanesulfonate(EMS)- or 32 J/m2 ultraviolet light(UV)-induced UDS at concentrations ranging from 1 microM to 50 microM. In contrast, retinol and retinoic acid significantly inhibited 2.5 micrograms/mL and 5.0 micrograms/mL 7,12-dimethyl-benz[a]anthracene(DMBA)-induced UDS at concentrations of 1 microM or greater. Retinol- and retinoic acid-induced hepatocytotoxicity was studied in vitro using lactate dehydrogenase (LDH) release as an indicator of cytoxicity. Neither retinol nor retinoic acid caused significant increases in LDH release over solvent control 3 hours after treatment, whereas retinol caused a biologically significant increase in LDH release 24 hours posttreatment at concentrations of 50 microM and 100 microM. These data suggest that nontoxic concentrations of retinol and retinoic acid do not inhibit the DNA excision repair process but apparently affect the effective DNA adduct load due to the ultimate species of DMBA metabolite responsible for hepatocellular DNA damage.
JF  - Environmental and molecular mutagenesis
AU  - Budroe, J D
AU  - Shaddock, J G
AU  - Casciano, D A
AD  - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Little Rock, Arkansas 72079.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 129
EP  - 139
VL  - 10
IS  - 2
SN  - 0893-6692, 0893-6692
KW  - Vitamin A
KW  - 11103-57-4
KW  - Tretinoin
KW  - 5688UTC01R
KW  - 9,10-Dimethyl-1,2-benzanthracene
KW  - 57-97-6
KW  - Ethyl Methanesulfonate
KW  - 9H154DI0UP
KW  - L-Lactate Dehydrogenase
KW  - EC 1.1.1.27
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Ultraviolet Rays
KW  - DNA Damage
KW  - L-Lactate Dehydrogenase -- analysis
KW  - Male
KW  - Tretinoin -- pharmacology
KW  - Ethyl Methanesulfonate -- pharmacology
KW  - 9,10-Dimethyl-1,2-benzanthracene -- pharmacology
KW  - Liver -- drug effects
KW  - Vitamin A -- pharmacology
KW  - Liver -- metabolism
KW  - DNA Repair -- drug effects
KW  - 9,10-Dimethyl-1,2-benzanthracene -- antagonists & inhibitors
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-02-16
N1  - Date created - 1988-02-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Cause-specific mortality among Rhode Island jewelry workers.
AN  - 77836473; 2961258
AB  - Cause-specific mortality patterns among Rhode Island jewelry manufacturing workers, as identified on death certificates from 1968 to 1978, were examined using the proportionate mortality ratio (PMR) method. Among males, elevated PMRs were observed for nonmalignant kidney disease (PMR = 163; Observed deaths [Obs] = 19; p less than or equal to .05), liver cancer (PMR = 297; Obs = 6; p less than or equal to .05), drug dependence (PMR = 379; Obs = 5; p less than or equal to .05), and accidental poisonings (PMR = 274; Obs = 8; p less than or equal to .05). All but one of the deaths from accidental poisonings involved drugs or drugs and alcohol. Among females, elevated PMRs were observed for stomach cancer (PMR = 174; Obs = 20; p less than or equal to .01), peptic ulcer (PMR = 235; Obs = 8; p less than or equal to .05), diseases of the skin and subcutaneous tissue (PMR = 383; Obs = 5; p less than or equal to .05), and drug dependence (PMR = 674; Obs = 3; p less than or equal to .05). Exposure to known renal toxins (heavy metals and solvents) used in the jewelry industry may account for the excess deaths from kidney disease. The elevated PMR for liver cancer may be due to exposure to solvents (trichloroethylene, perchloroethylene, carbon tetrachloride) that cause liver cancer in animals. The elevated PMRs for drug dependence and accidental poisonings may be due to the socioeconomic status of jewelry workers, or to the interaction between solvents used in jewelry manufacturing and drugs, or drugs and alcohol. Because of the lack of information about the specific occupational exposures of the decedents, this should be viewed as an exploratory investigation requiring further follow-up.
JF  - American journal of industrial medicine
AU  - Dubrow, R
AU  - Gute, D M
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 579
EP  - 593
VL  - 12
IS  - 5
SN  - 0271-3586, 0271-3586
KW  - Solvents
KW  - 0
KW  - Index Medicus
KW  - Dermatitis, Occupational -- mortality
KW  - Stomach Neoplasms -- mortality
KW  - Massachusetts
KW  - Risk Factors
KW  - Humans
KW  - Liver Neoplasms -- mortality
KW  - Substance-Related Disorders -- mortality
KW  - Solvents -- adverse effects
KW  - Kidney Diseases -- mortality
KW  - Male
KW  - Female
KW  - Peptic Ulcer -- mortality
KW  - Occupational Diseases -- chemically induced
KW  - Cause of Death
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-01-06
N1  - Date created - 1988-01-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - GEN
T1  - Report of the Surgeon General's Workshop on Children with HIV Infection and Their Families (Philadelphia, Pennsylvania, April 6-9, 1987).
AN  - 63168928; ED287568
AB  - This publication summarizes current knowledge about Acquired Immunodeficiency Syndrome (AIDS) in children and recommends future directions for research, prevention, and amelioration of the effects of pediatric AIDS. After an excerpt from Surgeon General Koop's keynote address, contents provide selections from workshop presentations concerning (1) the global epidemiology of AIDS; (2) the Human Immunodeficiency Virus (HIV); (3) the immunology of pediatric AIDS; (4) transmission of HIV in the United States; (5) approaches to prevention of HIV infection; (6) the natural history of HIV infection in children; (7) HIV transmitted by blood products; (8) supportive care and treatment of pediatric AIDS; (9) intravenous drug abuse and women's medical issues; (10) education to prevent HIV infection; (11) legal issues surrounding medical care, treatment, and research on children; (12) management of the child with HIV infection, with implications for service delivery; (13) developments in and prospects for AIDS vaccines; and (14) a mother's viewpoint on the needs of families of children with AIDS. Recommendations of 10 work groups, each of which focused on a specific set of issues, and the response of the Surgeon General are offered. Appendices provide related materials, such as guidelines for management of HIV, a list of selected readings, and a classification system for HIV infection in children under 13 years of age. (RH)
AU  - Silverman, Benjamin K.
AU  - Waddell, Anthony
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 115
KW  - Child Health
KW  - Immunology
KW  - Patient Management
KW  - ERIC, Resources in Education (RIE)
KW  - Workshops
KW  - Acquired Immune Deficiency Syndrome
KW  - Guidelines
KW  - Patients
KW  - Health Education
KW  - Children
KW  - Foster Care
KW  - Prevention
KW  - Epidemiology
KW  - Classification
KW  - Sexually Transmitted Diseases
KW  - Females
KW  - Global Approach
KW  - Drug Abuse
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LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Summary of Findings from National Children and Youth Fitness Study II.
AN  - 63161621; ED292780
AB  - This report is based on a survey of 4,678 children aged 6 to 9, examining their exercise habits at school, at home, and in community programs. The survey is the second in a series carried out by the Office of Disease Prevention and Health Promotion. The first report found that fitness has declined for 10- to 17-year-olds. In an effort to better understand why adolescents' fitness levels have declined, this national study was undertaken to learn the fitness status of younger children. The study shows that young children in America are fatter than children 20 years ago, are not getting the right kinds of exercise, and spend more time watching television than in physical activity. The better performers on the fitness tests participate in more vigorous and organized community-based activities, watch less television, and have a higher activity level. The research process and results are described in articles which include: an introduction (J. M. McGinnis); a summary of findings (James G. Ross and Russell R. Pate); "Study Procedures and Quality Control (James G. Ross, et al.); a sample design (Michael T. Errecart et al.); "The Modified Pull-Up Test" (Russell R. Pate et al.); and "Home and Community in Children's Exercise Habits" (James G. Rose et al.). (JD)
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 49
KW  - Child Health
KW  - ERIC, Resources in Education (RIE)
KW  - Elementary Education
KW  - Research Methodology
KW  - Community Programs
KW  - Physical Fitness
KW  - Parent Role
KW  - Exercise
KW  - Children
KW  - Physical Health
KW  - Physical Activity Level
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LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - School/Community-Based Alcoholism/Substance Abuse Prevention Survey.
AN  - 63084323; ED302348
AB  - This report describes school and community efforts to prevent alcoholism and substance abuse among American Indian and Alaskan Native youth. In 1986, the Indian Health Service (IHS) surveyed Bureau of Indian Affairs schools, public schools with large Indian enrollments, and community groups involved in 225 IHS-funded alcohol and substance abuse programs. Of 420 schools responding, 178 used a topical approach to alcohol/substance abuse education, while 86 were involved in one of five specific model programs; these 264 programs had 57,276 student participants on a predominantly weekly format. Program content most frequently included decision making, peer pressure, values clarification, physical and emotional effects of alcohol and substance abuse, and self-awareness and culture identity issues. Intervention activities focused on referral for counseling, psychological enrichment activities, and workshop/training. Observation of student and followup was the most frequently reported evaluation technique. Positive outcomes included increased self-esteem in 104 schools, and decreased disciplinary problems, increased attendance, and reduced substance abuse in about 60 schools each. Of 160 community programs responding, 137 targeted adolescents. Virtually all used topical materials plus one or more model programs; total participants numbered 31,946. Discussion and recommendations accompany each of 12 school and 11 community data tables. The report contains 53 references, data on Indian adolescent alcohol and substance abuse, IHS alcoholism and substance abuse objectives for 1995, brief descriptions of seven model programs, related mortality data, and the survey instrument. (SV)
AU  - Owan, Tom Choken
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 107
KW  - Indian Health Service
KW  - ERIC, Resources in Education (RIE)
KW  - Substance Abuse
KW  - Community Programs
KW  - Surveys
KW  - Elementary Secondary Education
KW  - Youth Programs
KW  - Children
KW  - American Indians
KW  - Prevention
KW  - Alcohol Abuse
KW  - Alcoholism
KW  - Drug Education
KW  - Alcohol Education
KW  - American Indian Education
KW  - Youth Problems
KW  - Alaska Natives
KW  - Adolescents
KW  - Drug Abuse
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LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - BOOK
T1  - Physician assistants: providing geriatric care
T2  - HRP-0907021
AN  - 59428094; 1987-1702950
AB  - Types of institutions utilizing PAs; services most commonly rendered.
JF  - Rockville, MD 20857, January 1987. iv+41 pp.
AU  - Schafft, Gretchen
AU  - Rolling, Barbara
Y1  - 1987/01//
PY  - 1987
DA  - January 1987
EP  - iv+41
PB  - Rockville, MD 20857
KW  - United States
KW  - Old age -- Medical care
KW  - Physicians' assistants
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Rockville, MD 20857
N1  - Document feature - table(s), chart(s)
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Storm drain discharge water quality and sedimentation pond performance
AN  - 51970582; 2003-050692
JF  - Cold Regions Environmental Engineering - Proceedings of the ... International Conference
AU  - Bandt, K E
AU  - Barrett, J K
AU  - Black, R D
A2  - Smith, D. W.
A2  - Tilsworth, T.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 176
EP  - 185
PB  - TekTran International, Kitchener, ON
VL  - 2
KW  - United States
KW  - water quality
KW  - suspended materials
KW  - Campbell Creek
KW  - sediments
KW  - coliform bacteria
KW  - storms
KW  - Anchorage Alaska
KW  - discharge
KW  - geochemistry
KW  - heavy metals
KW  - water supply
KW  - grain size
KW  - surface water
KW  - sedimentation
KW  - hydrochemistry
KW  - distribution
KW  - Southern Alaska
KW  - ponds
KW  - organic compounds
KW  - runoff
KW  - bacteria
KW  - hydrocarbons
KW  - turbidity
KW  - Alaska
KW  - lake sediments
KW  - 21:Hydrogeology
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LA  - English
DB  - GeoRef
N1  - Conference title - Second international conference
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute.
N1  - Date revised - 2003-01-01
N1  - PubXState - ON
N1  - Document feature - illus. incl. 4 tables
N1  - Last updated - 2012-06-07
N1  - CODEN - #06242
N1  - SubjectsTermNotLitGenreText - Alaska; Anchorage Alaska; bacteria; Campbell Creek; coliform bacteria; discharge; distribution; geochemistry; grain size; heavy metals; hydrocarbons; hydrochemistry; lake sediments; organic compounds; ponds; runoff; sedimentation; sediments; Southern Alaska; storms; surface water; suspended materials; turbidity; United States; water quality; water supply
ER  - 



TY  - JOUR
T1  - Rapid Determination of Methyl Mercury In Fish and Shellfish: Method Development
AN  - 19005502; 8706788
AB  - The AOAC official first action method for methyl mercury in fish and shellfish was modified to provide more rapid determination. Methyl mercury is isolated from homogenized, acetone-washed tissue by addition of HCl and extraction by toluene of the methyl mercuric chloride produced. The extract is analyzed by electron capture gas chromatography (GC) on 5% DEGS-PS treated with mercuric chloride solution. The quantitation limit of the method is 0.25 micrograms Hg/gram. Swordfish, shark, tuna, shrimp, clams, oysters, and NBS Research Material-50 (tuna) were analyzed for methyl mercury by the AOAC official first action method. All products also were analyzed by the modified method and the AOAC official method for total mercury. In addition, selected extracts obtained with the modified method were analyzed by GC with Hg-selective, microwave-induced helium plasma detection. There was no significant difference between the results for the various methods. Essentially all the Hg present (determined as total Hg) was in the organic form. Coefficients of variation from the analyses by the modified method ranged from 1 to 7% for fish and shellfish containing methyl mercury at levels of 0.50-2.3 micrograms Hg/gram. The overall average recovery was 100.5%. (Author 's abstract)
JF  - Journal - Association of Official Analytical Chemists JANCA2 Vol. 70, No. 1, p 24-30, January-February 1987. 1 fig, 5 tab, 14 ref.
AU  - Hight, S C
AU  - Corcoran, M T
AD  - Food and Drug Administration Washington, DC. Contaminants Chemistry Div
Y1  - 1987/01//
PY  - 1987
DA  - Jan 1987
KW  - Water Resources Abstracts
KW  - Pollutant identification
KW  - Mercury
KW  - Shellfish
KW  - Analytical methods
KW  - Sample preparation
KW  - Methyl mercury
KW  - Gas chromatography
KW  - Detection limits
KW  - Swordfish
KW  - Shark
KW  - Tuna
KW  - Shrimp
KW  - Fish
KW  - Clams
KW  - Mollusks
KW  - Oysters
KW  - Crustaceans
KW  - Comparison studies
KW  - Heavy metals
KW  - Performance evaluation
KW  - Tissue analysis
KW  - SW 0880:Chemical processes
KW  - SW 3010:Identification of pollutants
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Naphthalene Biodegradation in Environmental Microcosms: Estimates of Degradation Rates and Characterization of Metabolites
AN  - 18991715; 8706545
AB  - Naphthalene biodegradation was investigated in microcosms containing sediment and water collected from three ecosystems, two of which were located in Arkansas and one in Texas, which varied in past exposure to anthropogenic and petrogenic chemicals. Mineralization half-lives for naphthalene in microcosms ranged from 2.4 weeks in sediment chronically exposed to petroleum hydrocarbons to 4.4 weeks in sediment from a pristine environment. Microbiological analysis of sediments indicated that hydrocarbon-utilizing microbial populations also varied among ecosystems and were 5 to 12 times greater in sediment after chronic petrogenic chemical exposure than in sediment from an uncontaminated ecosystem. Sediment from an ecosystem exposed to agricultural chemicals had a mineralization half-life of 3.2 weeks for naphthalene and showed about a 30-fold increase in heterotrophic bacterial populations in comparison to uncontaminated sediments, but only a 2- to 3-fold increase in hydrocarbon-degrading bacteria. Analysis of organic solvent-extractable residues from the microcosms by high-pressure liquid chromatography detected polar metabolites which accounted for 1 to 3% of the total radioactivity. Purification of these residues by thin-layer chromatography and further analysis by gas chromatography-mass spectrometry indicated that cis-1,2-dihydroxy-1,2-dihydronaphthalene, 1-naphthol, salicylic acid, and catechol were metabolites of naphthalene. These results provide useful estimates for the rates of naphthalene mineralization in different natural ecosystems and on the degradative pathway for microbial metabolism of naphthalene in freshwater and estuarine environments. (Author 's abstract)
JF  - Applied and Environmental Microbiology AEMIDF Vol. 53, No. 1, p 129-136, January 1987. 7 fig, 1 tab, 48 ref.
AU  - Heitkamp, MA
AU  - Freeman, J P
AU  - Cerniglia, CE
AD  - National Center for Toxicological Research Jefferson, AR
Y1  - 1987/01//
PY  - 1987
DA  - Jan 1987
KW  - Water Resources Abstracts
KW  - Metabolites
KW  - Fate of pollutants
KW  - Pollutant identification
KW  - Biodegradation
KW  - Sediments
KW  - Naphthalene
KW  - Degradation
KW  - Hydrocarbons
KW  - Microbiological studies
KW  - Agricultural chemicals
KW  - Ecological effects
KW  - Mineralization
KW  - Bacteria
KW  - Heterotrophic bacteria
KW  - Chromatography
KW  - Radioactivity
KW  - Thin layer chromatography
KW  - Gas chromatography
KW  - Mass spectrometry
KW  - Ecosystems
KW  - Arkansas
KW  - Texas
KW  - Population exposure
KW  - SW 3010:Identification of pollutants
KW  - SW 0870:Erosion and sedimentation
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519945032
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944246
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944161
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - BOOK
T1  - Example problem--computer-aided ventilation design.
AN  - 15096297; 1891079
AU  - Clapp, DE
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 14
EP  - 192
KW  - computer aided design
KW  - computer applications
KW  - occupational health
KW  - occupational safety
KW  - ventilation
KW  - working conditions
KW  - Health & Safety Science Abstracts
KW  - H SI0.2:DATA ANALYSIS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - A Lotus 1-2-3 data base model for keeping and tracking citations.
AN  - 15095725; 1891013
AB  - When reviewing literature for a publication on the reproductive toxicity of glycol ethers, it was necessary to organize information from a large number of publications dealing with many different glycol ethers, many test species, and multiple routes of exposure. To simplify organization and retrieval of that information, a Lotus data base was set up in which the key information and freeform comments could be entered. New references can be added as they accumulate to keep the data base up-to-date.
AU  - Hardin, B D
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 4
EP  - 158
KW  - Lotus 1-2-3
KW  - data bases
KW  - occupational health
KW  - occupational safety
KW  - reproduction
KW  - toxicology
KW  - Health & Safety Science Abstracts
KW  - H SI0.2:DATA ANALYSIS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - In vivo induction of sister chromatid exchanges in mice by nitrosated coal dust extract.
AN  - 15021550; 1830755
AB  - The genotoxicity of coal dust extract nitrosated with sodium nitrite (NaNO sub(2)) was investigated in mice with the in vivo sister chromatid exchange (SCE) assay system. Coal dust extract and NaNO sub(2) separately did not cause significant increases of SCEs either in single or in double dosings. Nitrosated coal dust extract in single doses did not increase SCEs but in two doses significant increases in SCEs were observed. The mutagenicity of the same extracts was tested in Salmonella typhimurium) with the Ames tester strain TA98. Coal dust extract was either non- or weakly mutagenic and NaNO sub(2) was nonmutagenic. The nitrosated coal dust extract caused pronounced increases in his super(+) revertants both with and without rat liver S9 activation. The findings provide additional evidence that nitrosation of ingested coal dust which may occur in the stomach environment could be one of the factors leading to the higher incidence of gastric cancer in coal miners.
JF  - Environmental Research
AU  - Krishina, G
AU  - Nath, J
AU  - Soler, L
AU  - Ong, T
AD  - NIOSH, Div. Respir. Dis. Stud., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 106
EP  - 113
VL  - 42
IS  - 1
SN  - 0013-9351, 0013-9351
KW  - induction
KW  - coal dust
KW  - sodium nitrate
KW  - mice
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - sister chromatid exchange
KW  - coal
KW  - genotoxicity
KW  - dust
KW  - H SM5.8.2:CHEMICALS (CORROSION)
KW  - X 24151:Acute exposure
KW  - H SE4.20:POISONS AND POISONING
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SI2.20:COAL INDUSTRIES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - genotoxicity; sister chromatid exchange; mice; coal; dust; coal dust
ER  - 



TY  - JOUR
T1  - Request for assistance in reducing the potential risk of developing cancer from exposure to gallium arsenide in the microelectronics industry.
AN  - 14982014; 1800225
AB  - Various methods through which exposure to gallium arsenide might be reduced in the microelectronics industry were discussed. While there were no reported studies showing ill effects in workers from exposure to gallium-arsenide or gallium particulates, three studies in animals indicated that gallium-arsenide dissociates into gallium and arsenic in biological tissue, the latter being a carcinogen. NIOSH Recommended Exposure Limit (REL) for arsenic was 2 micrograms/cubic meter air (microg/cum). NIOSH recommends control of worker exposure to gallium-arsenide by observing NIOSH REL for inorganic arsenic, and that concentration of gallium-arsenide in air be estimated by determining arsenic. Proper engineering controls should be installed during production of microelectronic devices where exposure to gallium-arsenide is likely. Personal protective clothing and equipment should be available to workers, and proper procedures for washing, removal of wastes, transport, and disposal of contaminated materials should be explained and carried out.
JF  - . 1987.
Y1  - 1987
PY  - 1987
DA  - 1987
KW  - gallium arsenide
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - risk assessment
KW  - cancer
KW  - electronics industry
KW  - occupational exposure
KW  - H SI10.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB88-188826/GAR.
N1  - Last updated - 2015-04-07
ER  - 



TY  - JOUR
T1  - Dust exposures at U.S. surface coal mines in 1982-1983.
AN  - 14907045; 1729744
AB  - Exposures to British Mining Research Establishment corrected respirable dust and respirable quartz at U.S. surface coal mines during 1982-1983 were evaluated from coal mine operator and Mine Safety and Health Administration inspector samples. The average respirable quartz concentration from inspector samples ranged from .34-.49 mg/m super(3) for drilling and .18 mg/m super(3) for bulldozer operators. For most other surface coal mine jobs, the average respirable quartz concentration was less .1 mg/m super(3), and the average respirable dust concentration was less than 2 mg/m super(3). The results from the analysis of quartz exposures are consistent with epidemiological results for an increased silicosis risk among drillers.
JF  - Archives of Environmental Health
AU  - Amandus, HE
AU  - Piacitelli, G
AD  - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505 USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 374
EP  - 381
VL  - 42
IS  - 6
SN  - 0003-9896, 0003-9896
KW  - surface mining
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational health
KW  - dust
KW  - surveys
KW  - pneumoconiosis
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - H SI2.8.7:DUST
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SM10.24:PULMONARY DISEASES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - dust; occupational health; surveys; pneumoconiosis
ER  - 



TY  - BOOK
T1  - Epidemiology of populations exposed to dioxins.
AN  - 14880165; 1720464
AB  - A historical review of studies of human exposure to dioxin-contaminated substances is presented, with emphasis on 2,3,7,8-tetrachlorodibenzodioxin (2,3,7,8-TCDD). Exposed populations include production workers, herbicide sprayers, persons exposed to Agent Orange, and residents of Missouri, U.S.A. and Seveso, Italy. Published medical reports have described chloracne, asthenia, neurological problems, and hepatotoxicity, but some of these studies have not had adequate comparison populations. Some recent epidemiologic studies have concluded that no outcomes could be attributed to dioxin exposure, but others have found associations of exposure with soft tissue sarcoma, lymphoma, nasal and stomach cancer. These studies are described.
JF  - ACS Symposium Series [ACS SYMP. SER.]. 1987.
AU  - Fingerhut, MA
AU  - Sweeney, M H
AU  - Halperin, W E
AU  - Schnorr, T M
A2  - Exner, JH (ed)
Y1  - 1987
PY  - 1987
DA  - 1987
SN  - 084121025X
KW  - Pollution Abstracts
KW  - toxicity
KW  - TCDD
KW  - epidemiology
KW  - contamination
KW  - public health
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14880165?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - PAT
T1  - Soluble interleukin-2 receptor as a disease indicator and a method of assaying the same.
AN  - 14853336; 1685515
AU  - Nelson, D
AU  - Biddison, W
AU  - Rubin, L
AU  - Greene, W
AU  - Leonard, W
AU  - Yarchoan, R
PY  - 1987
IS  - US Patent 4,707,443
KW  - receptors
KW  - enzyme-linked immunosorbent assay
KW  - interleukin 2
KW  - patents
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30050:Patents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/7; Int. Cl. G01N 33/53.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Methyl isocyanate liquid and vapor permeation through selected respirator diaphragms and chemical protective clothing.
AN  - 14852807; 1685609
AB  - A study was undertaken to evaluate selected chemical protective clothing suitable for use by emergency response personnel confronted with methyl isocyanate (MIC). Twenty-two chemical protective clothing materials were tested against liquid methyl isocyanate. Chemical permeation breakthrough times for these clothing materials demonstrate that only one of these garments can be considered as a candidate material against liquid MIC. In a subsequent study, three chemical protective clothing materials were evaluated against approximately 800 ppm MIC vapor. Chemical permeation breakthrough times demonstrate that these materials can be considered candidate materials. A final study tested self-contained breathing apparatus (SCBA) diaphragms. Four SCBA diaphragms were tested and all experienced rapid breakthrough when exposed to liquid MIC. Next, three SCBA diaphragms were exposed to approximately 800 ppm MIC vapor. The data demonstrate that the SCBA should be worn inside a total encapsulating suit.
JF  - American Industrial Hygiene Association Journal
AU  - Berardinelli, S P
AU  - Moyer, E S
AD  - U.S. DHHS, Public Health Serv., CDC, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 324
EP  - 329
VL  - 48
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - protective clothing
KW  - respirators
KW  - methyl isocyanate
KW  - vapor
KW  - Pollution Abstracts
KW  - occupational health
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Methyl+isocyanate+liquid+and+vapor+permeation+through+selected+respirator+diaphragms+and+chemical+protective+clothing.&rft.au=Berardinelli%2C+S+P%3BMoyer%2C+E+S&rft.aulast=Berardinelli&rft.aufirst=S&rft.date=1987-01-01&rft.volume=48&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health
ER  - 



TY  - JOUR
T1  - Generation of methyl isocyanate through organic vapor and acid gas respirator cartridges.
AN  - 14852214; 1685522
AB  - This report addresses only MIC penetration through air-purifying cartridges at challenge concentrations designed to simulate emergency escape conditions. Another report addresses thee protective clothing issue. The results presented are for two different manufacturers' organic vapor (OV) and acid gas cartridges. Penetration tests were conducted at three or four MIC challenge concentrations and at three different humidity conditions. In general, breakthrough times (1% of challenge concentration) were very short (< 20 min). Also, high relative humidity was found to decrease the breakthrough time of MIC.
JF  - American Industrial Hygiene Association Journal
AU  - Moyer, E S
AU  - Berardinelli, S P
AD  - Public Health Serv., CDC, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 315
EP  - 323
VL  - 48
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - respirators
KW  - methyl isocyanate
KW  - vapor
KW  - Pollution Abstracts
KW  - humidity
KW  - occupational health
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - humidity; occupational health
ER  - 



TY  - JOUR
T1  - Respiratory health status of gilsonite workers.
AN  - 14847745; 1669650
AB  - Gilsonite, a solidified hydrocarbon used in the manufacture of automotive body seam sealers, is mined only in the Uinta Basin of Eastern Utah and Western Colorado. Health effects of gilsonite dust exposure have not previously been published and exposure to gilsonite dust is not regulated. To examine potential respiratory health effects associated with gilsonite dust exposures, this cross-sectional study surveyed the 100 current male employees who had been exposed to gilsonite dust at 3 existing gilsonite companies. Total dust exposures up to 28 times the nuisance dust standard were found, and 5 of 99 (5%) workers had chest radiographs consistent with pneumoconiosis of low profusion. Increased prevalences of cough and phlegm were found in workers with high-exposure jobs, but no evidence for dust-related pulmonary function impairment was noted.
JF  - American Journal of Industrial Medicine
AU  - Keimig, D G
AU  - Castellan, R M
AU  - Kullman, G J
AU  - Kinsley, K B
AD  - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 287
EP  - 296
VL  - 11
IS  - 3
SN  - 0271-3586, 0271-3586
KW  - effects on
KW  - uintahite
KW  - respiratory systems
KW  - Toxicology Abstracts
KW  - occupational exposure
KW  - man
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; man
ER  - 



TY  - JOUR
T1  - Evaluation of the single radial-immunodiffusion assay for measuring the glycoprotein content of rabies vaccines.
AN  - 14845338; 1673537
AB  - The glycoprotein content of rabies vaccines containing the Pitman-Moore strain of rabies virus was measured by the single radial immunodiffusion assay and correlated with vaccine potency. Single radial-immunodiffusion values for Pitman-Moore vaccines correlated with the manufactures' NIH potency assay, but required a mathematical transformation to convert values from one assay to the other. Modification of the single radial immunodiffusion technique and the feasibility of using this assay for the determination of rabies vaccine potency are discussed.
JF  - Biologicals
AU  - Mayner, R E
AU  - Needy, C F
AD  - Dep. Health and Hum. Serv., Public Health Serv., FDA, Cent. Drugs and Biol., Off. Biol. Res. and Rev., 8800 Rockville Pike, Bethesda, MD 20205, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 1
EP  - 10
VL  - 15
IS  - 1
SN  - 0092-1157, 0092-1157
KW  - content
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts
KW  - glycoproteins
KW  - vaccines
KW  - rabies virus
KW  - immunodiffusion
KW  - V 22097:Immunization: Vaccines & vaccination: Human
KW  - A 01097:Viruses
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - rabies virus; vaccines; glycoproteins; immunodiffusion
ER  - 



TY  - JOUR
T1  - Reduced work tolerance associated with wearing protective clothing and respirators.
AN  - 14840688; 1684163
AB  - This study examined worker tolerance and physiological responses to two levels of work while subjects wore various types of protective clothing and respirators. Nine healthy men, experienced with the use of respirators, each performed a randomized series of eight experimental tests, each test scheduled to last 180 min. Work was performed on a motor-driven treadmill at a set walking speed and elevation indicative of either 30% or 60% of maximum work capacity for each individual.
JF  - American Industrial Hygiene Association Journal
AU  - White, M K
AU  - Hodous, T K
AD  - Div. Saf. Res., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 304
EP  - 310
VL  - 48
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - respirators
KW  - ventilations
KW  - Health & Safety Science Abstracts
KW  - physiology
KW  - protective clothing
KW  - ergonomics
KW  - H SI6.7:HUMAN FACTORS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - protective clothing; physiology; ergonomics
ER  - 



TY  - JOUR
T1  - Development and use a sampling and analytical method for azodicarbonamide.
AN  - 14840089; 1683728
AB  - Azodicarbonamide is a medium temperature blowing used in the production of foamed polymers. Because of worker concern over health effects associated with its use, researchers from the National Institute for Occupational Safety and Health (NIOSH) conducted two health hazard evaluations. This paper describes the health concerns, the sampling and analytical method used, the environments sampled and the results of these surveys. Environmental samples were collected on Teflon) filters for total dust and airborne concentration of azodicarbonamide. Analysis was accomplished by high performance liquid chromatography with identification and quantitation by UV detector response rationing. Use of this method provided the sensitivity and specificity to analyze airborne azodicarbonamide concentrations and allowed evaluation of a workplace environment for a respiratory health hazard.
JF  - American Industrial Hygiene Association Journal
AU  - Ahrenholz, SH
AU  - Neumeister, CE
AD  - Div. Surveil. Hazard Eval. and Field Stud., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 442
EP  - 446
VL  - 48
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - azodicarbonamide
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - liquid chromatography
KW  - occupational health
KW  - air quality
KW  - dust
KW  - surveys
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - H SM6.8.7:DUST
KW  - P 0000:AIR POLLUTION
KW  - H SI0.8.7:DUST
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; surveys; liquid chromatography; air quality; dust
ER  - 



TY  - JOUR
T1  - IgA glomerulonephritis in a plumber working with solvent-based pipe cement.
AN  - 14839517; 1684393
AB  - A request for health hazard evaluation was submitted to the National Institute for Occupational Safety and Health (NIOSH) from a 28-year-old male self-employed plumber who has been working with plastic pipe and pipe cement for 9 1/2 years. Recently, he had been seen by a physician for gross hematuria. Needle biopsy of the kidney, with immunofluorescence, light, and electron microscopic examination showed segmental proliferative glomerulonephritis with IgA deposits. He had no family history of kidney disease. These findings, as well as the presence of capillary adhesions to Bowman's capsule and fibrin in the glomerular mesangial deposits, were indicative of progressive disease.
JF  - Industrial Health
AU  - Albrecht, W N
AU  - Boiano, J M
AU  - Smith, R D
AD  - Natl. Inst. Occup. Saf. and Health (NIOSH), 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 157
EP  - 158
VL  - 25
IS  - 3
SN  - 0019-8366, 0019-8366
KW  - glomerulonephritis
KW  - man
KW  - kidneys
KW  - occupational health
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - pipes
KW  - solvents
KW  - cement
KW  - kidney
KW  - occupational exposure
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - X 24152:Chronic exposure
KW  - H SI1.8.2:CHEMICALS (CORROSION)
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cement; solvents; occupational exposure; occupational health; pipes; kidney; glomerulonephritis; man
ER  - 



TY  - JOUR
T1  - Regulation of food, drugs and medical devices in the USA.
AN  - 14839072; 1684002
AB  - For 80 years the United States Food and Drug Administration (FDA) has had the major responsibility for safeguarding the foods, medicines, and medical and radiation-emitting devices marketed in the United States. Its primary mission is to protect the health of the American public by prohibiting commerce in adulterated and misbranded food and drugs. However, its work has ramifications of importance to people throughout the world. Because FDA's jurisdiction extends to many thousands of products that move in international commerce, and because of extensive collaboration with governments in all parts of the world and with multilateral bodies, the actions of FDA and the policies that guide them can have a significant, long-term bearing on the health and well-being of people in every corner of the globe.
JF  - World Health Forum
AU  - Nightingale, S L
AD  - Health Affairs, U.S. FDA, Rockville, MD 20857, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 461
EP  - 468
VL  - 8
IS  - 4
SN  - 0251-2432, 0251-2432
KW  - FDA
KW  - United States
KW  - foods
KW  - Health & Safety Science Abstracts
KW  - drugs
KW  - federal regulations
KW  - public health
KW  - H SE4.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - public health; drugs; federal regulations
ER  - 



TY  - JOUR
T1  - An ion chromatographic method for insoluble chromates in paint aerosol.
AN  - 14838269; 1684549
AB  - A new method of analysis has been developed that uses ion chromatography (IC) for the measurement and which does not require acidification of the sample. In this method, the same extraction solution of hot 2% NaOH and 3% Na sub(2)CO sub(3) as used in the earlier methods is used to dissolve both soluble and insoluble chromates, but it can be carried through the method with only a dilution step before sample injection. Therefore, this method has the advantage of minimizing the potential for Cr(VI) loss by reduction. Another advantage is provided by the IC measurement step, which is not interfered with by colored samples that may affect the colorimetric method. The new method was tested with filter samples of paint aerosol containing PbCrO sub(4) and ZnCrO sub(4). Complete extraction of Cr(VI) from the filter samples was verified by comparison to an independent method in which the filter was completely ashed and analyzed by inductively coupled plasma-atomic emission spectroscopy method.
JF  - American Industrial Hygiene Association Journal
AU  - Molina, D
AU  - Abell, M T
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 830
EP  - 835
VL  - 48
IS  - 10
SN  - 0002-8894, 0002-8894
KW  - monitoring measurements
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - chromatography
KW  - occupational health
KW  - aerosols
KW  - paints
KW  - spectroscopy
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - H SI6.21:PAINT INDUSTRIES
KW  - P 0000:AIR POLLUTION
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - paints; aerosols; chromatography; spectroscopy; occupational health
ER  - 



TY  - JOUR
T1  - Morbidity from repetitive knee trauma in carpet and floor layers.
AN  - 14838236; 1683655
AB  - Carpet layers comprise less than 0.6% of the United States workforce yet they submit 6.% of compensation claims for traumatic knee inflammation. Their work involves multiple sources of acute and chronic knee trauma including kneeling, pressure from sharp objects, and use of a device called a "knee kicker" to stretch wall to wall carpet. To characterise the knee morbidity in carpet layers and to identify occupational risk factors, a questionnaire was completed by 112 carpet and floor layers, 42 tile and terrazo setters, and 243 millwrights and bricklayers (MWBL). The MWBL comparison workers seldom kneel and do not use a knee kicker.
JF  - Occupational and Environmental Medicine
AU  - Thun, M
AU  - Tanaka, S
AU  - Smith, A
AU  - Halperin, W E
AU  - Lee, ST
AU  - Luggen, ME
AU  - Vess, E V
AD  - Div. Surveill., Hazard Eval. and Field Stud., NIOSH, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 611
EP  - 620
VL  - 44
IS  - 9
SN  - 0007-1072, 0007-1072
KW  - carpet layers
KW  - knee injuries
KW  - United States
KW  - Health & Safety Science Abstracts
KW  - surveys
KW  - morbidity
KW  - occupational health
KW  - H SM9.47:FOOT INJURIES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - morbidity; occupational health; surveys
ER  - 



TY  - JOUR
T1  - Development of a model to aid in reconstruction of historical silica dust exposures in the taconite industry.
AN  - 14837895; 1684585
AB  - The ability to reconstruct employee exposure histories would be a valuable research for the evaluation of occupation as a factor in disease. In many cases historical environmental data are available but have not been used to compute past exposures because of differences in sampling methods. This paper describes a quantitative model to convert historical environmental data (from taconite mine and mill operations) into a form consistent with current sampling methods and results and will enable past exposure histories to be used. (Past exposure histories are to be determined in an epidemiological study.) Parallel sampling results from the environmental data base were used to obtain a coefficient for the conversion of impinger-particle counts (old sampling method) to filter-respirable mass sampling results (new sampling method). Parameters in the model were estimated using multiple regression techniques. Results show that a consistent ratio exists between impinger-particle counts and filter-respirable mass concentrations for samples collected at the same locations.
JF  - American Industrial Hygiene Association Journal
AU  - Sheehy, J W
AU  - McJilton, CE
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 914
EP  - 918
VL  - 48
IS  - 11
SN  - 0002-8894, 0002-8894
KW  - historical account
KW  - taconite
KW  - occupational health
KW  - air sampling
KW  - silicon dioxide
KW  - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts
KW  - mining
KW  - dust
KW  - occupational exposure
KW  - H SM6.8.7:DUST
KW  - P 0000:AIR POLLUTION
KW  - X 24222:Analytical procedures
KW  - H SI2.8.7:DUST
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - dust; occupational health; air sampling; occupational exposure; mining
ER  - 



TY  - JOUR
T1  - Organic vapor (OV) respirator cartridge testing - potential Jonas model applicability.
AN  - 14837227; 1684749
AB  - Based on Jonas' kinetic model one method has potential application for evaluating OV cartridges and more efficiently utilizing available research, testing and certification resources. Jonas has shown that the kinetic adsorption capacity and gas adsorption rate of a small packed charcoal sorbent bed is described by the linear relationship between gas breakthrough time and sorbent weight as predicted by the modified Wheeler equation. This research is based on the hypothesis that characterizing sorbent performance against a reference compound will allow prediction of breakthrough times, and therefore prediction of cartridge life, for other compounds under similar conditions. Baseline data on dried cartridges at dry conditions are presented that demonstrate that the linear relationship between breakthrough time and sorbent weight that Jonas showed for small sorbent columns also holds when commercially manufactured respirator cartridges are stacked in series to resemble a packed column of varying bed length and sorbent weight. This suggests the potential applicability of the Jonas model for characterizing and evaluating commercially available OV respirator cartridges.
JF  - American Industrial Hygiene Association Journal
AU  - Moyer, E S
AD  - U.S. DHHS, Public Health Serv., CDC, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 791
EP  - 797
VL  - 48
IS  - 9
SN  - 0002-8894, 0002-8894
KW  - respirators
KW  - vapor
KW  - Pollution Abstracts
KW  - organic compounds
KW  - performance
KW  - kinetics
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14837227?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Organic+vapor+%28OV%29+respirator+cartridge+testing+-+potential+Jonas+model+applicability.&rft.au=Moyer%2C+E+S&rft.aulast=Moyer&rft.aufirst=E&rft.date=1987-01-01&rft.volume=48&rft.issue=9&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - organic compounds; performance; kinetics
ER  - 



TY  - JOUR
T1  - Environmental sampling and analysis for zeranol.
AN  - 14836983; 1685389
AB  - Due to concern over health effects associated with the use of zeranol, a sampling and analytical method to monitor zeranol in the work environment was developed. The collection strategy included air samples on FHLP filters, area samples on gauze pads, hand/dermal samples on gauze pads and bulk samples. The sampling method evaluation included choice of media, flow rate and duration for air samples, sample preparation, extraction efficiencies and samples stability. Analysis of the samples was accomplished by high performance liquid chromatography with identification and quantification by UV and fluorescence detection. The analytical method evaluation included separation of possible interfering compounds, calibration curves, limits of detection (LOD), limits of quantitation (LOQ), precision and accuracy. The tested analytical range was 0.01 to 150 mu g/mL with a LOD of 0.007 mu g/mL and a LOQ of 0.02 mu g/mL using UV detection.
JF  - American Industrial Hygiene Association Journal
AU  - Neumeister, CE
AD  - U.S. DHHS, Public Health Serv., CDC, NIOSH, Div. Phys. Sci. and Eng., 4676 Columbus Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 919
EP  - 921
VL  - 48
IS  - 11
SN  - 0002-8894, 0002-8894
KW  - zeranol
KW  - Pollution Abstracts
KW  - liquid chromatography
KW  - flow rates
KW  - air sampling
KW  - occupational health
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14836983?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - air sampling; flow rates; liquid chromatography; occupational health
ER  - 



TY  - JOUR
T1  - Determination of 2,3-dibromopropanol in air.
AN  - 14836899; 1683626
AB  - One of the starting materials for the preparation of TRIS-BP(Tris-2,3-dibromopropanol phosphate), which is used in the treatment of fabrics and various materials to make them nonflammable, is 2,3-dibromopropanol. A sensitive air sampling and analytical method has been developed as part of a complete field survey protocol. This paper describes the development of an air sampling and gas-liquid chromatographic analysis procedure for 2,3-dibromopropanol.
JF  - American Industrial Hygiene Association Journal
AU  - Choudhary, G
AD  - U.S. DHHS, Public Health Serv., CDC, NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 809
EP  - 813
VL  - 48
IS  - 9
SN  - 0002-8894, 0002-8894
KW  - 2,3-dibromopropanol
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - chromatography
KW  - fire retardants
KW  - air sampling
KW  - H SE8.21:PROTECTIVE MATERIALS
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14836899?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - air sampling; chromatography; fire retardants
ER  - 



TY  - PAT
T1  - Screening test for reverse-transcriptase containing virus such as non-A, non-B hepatitis, NANBH.
AN  - 14836673; 1685286
AU  - Seto, B P
AU  - Coleman, W G
AU  - Gerety, R J
PY  - 1987
IS  - US Patent 4,707,439
KW  - screening
KW  - detection
KW  - non-A, non-B hepatitis
KW  - patents
KW  - reverse transcriptase
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30050:Patents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/5; Int. Cl. C12Q 1/00.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Development of a sampling and analytical method for measuring the epoxy content of aerosols: I. Development of the analytical method.
AN  - 14836170; 1685054
AB  - A method has been developed for determining the quantity of the epoxide functional group in pure epoxy resins, resins in partially-cured mixtures with amine curing agents, and commercial epoxy surface coatings. The method is based upon the reaction of the epoxide group with bromide in the presence of acid, with measurement of excess bromide in the reaction mixture by normal pulse polarography. The method extends the range of previously reported methods for epoxy analysis to samples containing 1 to 100 microequivalents ( mu eq) of epoxide functionality, while maintaining good precision and accuracy (coefficient of variation < 0.006; accuracy within 2% of expected). The method has been developed for application to analysis of the epoxy content of environmental aerosols such as those of epoxy paint sprays.
JF  - American Industrial Hygiene Association Journal
AU  - Herrick, R F
AU  - Smith, T J
AD  - NIOSH, Div. Surveill., Hazard Eval. and Field Stud., Industrywide Stud. Branch, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 766
EP  - 772
VL  - 48
IS  - 9
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - sprays
KW  - resins
KW  - solvents
KW  - aerosols
KW  - paints
KW  - H SI6.21:PAINT INDUSTRIES
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14836170?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - aerosols; paints; sprays; resins; solvents
ER  - 



TY  - JOUR
T1  - A breakthrough time comparison of nitrile and neoprene glove materials produced by different glove manufacturers.
AN  - 14828124; 1683677
AB  - Specimens of similar nominal thickness from commercially available nitrile and neoprene gloves were each tested for breakthrough time against three chemicals. The null hypothesis was that the breakthrough times for the glove specimens of the same generic type but produced by different manufacturers would be the same. Breakthrough time data for each material/chemical combination were analyzed using an analysis of covariance to adjust for differences in the measured specimen thickness while testing for product differences. A significant difference in chemical breakthrough times was found among generically similar products produced by different manufacturers. The largest difference between the mean breakthrough time of two generically equivalent products, 30 vs. 300 min, was obtained for perchloroethylene through nitrile products. In conclusion, breakthrough time data for use in selection of chemical protective clothing or in prediction modeling for chemical protective clothing should be manufacturer and product specific.
JF  - American Industrial Hygiene Association Journal
AU  - Mickelsen, R L
AU  - Hall, R C
AD  - U.S. DHHS, Public Health Serv., CDC, NIOSH, Div. Res., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 941
EP  - 947
VL  - 48
IS  - 11
SN  - 0002-8894, 0002-8894
KW  - protective clothing
KW  - permeability
KW  - nitrile
KW  - neoprene
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - risk assessment
KW  - manufacturing industry
KW  - H SI6.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - risk assessment; manufacturing industry
ER  - 



TY  - JOUR
T1  - A portable chemical protective clothing test method: application at a chemical plant.
AN  - 14827962; 1683458
AB  - The National Institute for Occupational Safety and Health (NIOSH), in cooperation with Monsanto Chemical Company, conducted an on-site evaluation of chemical protective clothing at Monsantos Nitro, West Virginia plant. The Monsanto plant manufactures additives for the rubber industry including antioxidants, pre-vulcanization inhibitors, accelerators, etc. This survey evaluated six raw materials that have a potential for skin absorption: aniline, cyclohexylamine, diisopropylamine, tertiary butylamine, morpholine and carbon disulfide. Five generic glove materials were tested against these chemicals: nitrile, neoprene, polyvinylchloride, natural latex and natural rubber. The NIOSH chemical permeation portable test system was used to generate breakthrough time data.
JF  - American Industrial Hygiene Association Journal
AU  - Berardinelli, S P
AU  - Rusczek, R A
AU  - Mickelsen, R L
AD  - NIOSH, Div. Saf. Res., Injury Prev. Res. Branch, Prot. Equip. Sect., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888 USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 804
EP  - 808
VL  - 48
IS  - 9
SN  - 0002-8894, 0002-8894
KW  - protective materials
KW  - Health & Safety Science Abstracts
KW  - chemical industry
KW  - materials testing
KW  - surveys
KW  - rubber products
KW  - H SI6.13:INSTRUMENTATION, DEVICES AND CONTROLS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - surveys; materials testing; rubber products; chemical industry
ER  - 



TY  - JOUR
T1  - Formate in urine as a biological indicator of formaldehyde exposure: A review.
AN  - 14825716; 1685405
AB  - Unfortunately, the use of urine formate as a technique for monitoring personal chemical exposure has yet to be evaluated. This review identifies several potentially important variables that could alter the extent to which formate is eliminated through the urine and that could affect the accuracy of using urine formate concentration as an indicator of chemical exposure. Some potentially important confounders that have been identified, but not evaluated adequately, include dietary intake, nutritional status and exposure to cigarette smoke. The metabolism and elimination kinetics have yet to be adequately demonstrated in humans.
JF  - American Industrial Hygiene Association Journal
AU  - Boeniger, M F
AD  - Industrywide Stud. Branch, NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 900
EP  - 908
VL  - 48
IS  - 11
SN  - 0002-8894, 0002-8894
KW  - indicators
KW  - bioindicators
KW  - formaldehyde
KW  - occupational health
KW  - Toxicology Abstracts; Pollution Abstracts
KW  - reviews
KW  - toxicology
KW  - urine
KW  - occupational exposure
KW  - X 24222:Analytical procedures
KW  - X 24153:Metabolism
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Formate+in+urine+as+a+biological+indicator+of+formaldehyde+exposure%3A+A+review.&rft.au=Boeniger%2C+M+F&rft.aulast=Boeniger&rft.aufirst=M&rft.date=1987-01-01&rft.volume=48&rft.issue=11&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - bioindicators; formaldehyde; toxicology; reviews; occupational health; urine; occupational exposure
ER  - 



TY  - CONF
T1  - Are coal miners at increased risk for scar cancer?.
AN  - 14819172; 1669135
AB  - The relationship between scarring of the lung and the development of lung cancer has been a topic of great interest. It has been suggested that scarring of the lung is a predisposing factor in the development of cancer and serves as a nidus of growth. Many pathogenic factors, such as exposure to asbestos, beryllium and silica, and focal fibrosing factor, such as injury, tuberculosis, pneumonia and infarct, have been implicated as etiologic agents. Others suggested that scarring results from a desmoplastic reaction to tumor, ie, the tumor causes the scarring and the severity of scar is inversely correlated with survival. This hypothesis is supported by the recent studies on collagen subtypes associated with the scars in lung cancers. Repeated episodes of tumor necrosis also have been suggested as a mechanism of scar tissue formation.
JF  - CHEST.
AU  - Vallyathan, V
AU  - Althouse, R
AU  - Green, FHY
AU  - Boyd, C
AU  - Rodman, N
Y1  - 1987
PY  - 1987
DA  - 1987
VL  - 91
KW  - risks
KW  - Toxicology Abstracts
KW  - mining
KW  - lung
KW  - coal
KW  - man
KW  - carcinoma
KW  - X 24152:Chronic exposure
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14819172?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - CONF
T1  - Overview of usefulness of pharmacokinetics in minor species/use applications in the center for veterinary medicine.
AN  - 14813320; 1653645
AB  - In order to achieve its effect, a drug must be administered to an animal in appropriate dose. The site of administration must be such that an appropriate dose will be absorbed for transport to the site of action and maintain that concentration for a suitable period of time. The intensity of the response will be related to the concentration at the site of action, which is in turn proportional to the blood level of the drug. If the concentration at the site of action is above a certain level, the animal may demonstrate a toxic response.
JF  - Veterinary and Human Toxicology
AU  - Weissinger, J
Y1  - 1987
PY  - 1987
DA  - 1987
VL  - 29
KW  - pharmacokinetics
KW  - toxicity
KW  - Toxicology Abstracts
KW  - animals
KW  - drugs
KW  - safety regulations
KW  - conferences
KW  - X 24230:Legislation & recommended standards
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14813320?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+Human+Toxicology&rft.atitle=Overview+of+usefulness+of+pharmacokinetics+in+minor+species%2Fuse+applications+in+the+center+for+veterinary+medicine.&rft.au=Weissinger%2C+J&rft.aulast=Weissinger&rft.aufirst=J&rft.date=1987-01-01&rft.volume=29&rft.issue=&rft.spage=no.+1+Sul.&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+Human+Toxicology&rft.issn=01456296&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - CONF
T1  - Environmental considerations for minor use animal drugs.
AN  - 14813302; 1653255
AB  - This presentation outlines the basis for the FDA requirement that environmental considerations, via an environmental document, be included for evaluation as part of the application for animal drugs. Next, the environmental document for an animal drug application and three important types of environmental information that need to be included in the environmental document are discussed. The abbreviated environmental information requirements for some minor use applications are presented.
JF  - Veterinary and Human Toxicology
AU  - Zeeman, M
Y1  - 1987
PY  - 1987
DA  - 1987
VL  - 29
KW  - Toxicology Abstracts
KW  - reviews
KW  - animals
KW  - drugs
KW  - safety regulations
KW  - environmental effects
KW  - X 24230:Legislation & recommended standards
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14813302?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+Human+Toxicology&rft.atitle=Environmental+considerations+for+minor+use+animal+drugs.&rft.au=Zeeman%2C+M&rft.aulast=Zeeman&rft.aufirst=M&rft.date=1987-01-01&rft.volume=29&rft.issue=&rft.spage=no.+1+Sul.&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+Human+Toxicology&rft.issn=01456296&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Food intake and mortality in the United States.
AN  - 14801018; 1650980
AB  - Patterns of food intake and cause-specific death rates were compared for population groups of the United States for 1965, the first year of which national files are available. Aging was a much more important determinant of death rates than type of food eaten. There were no strong patterns of rank correlations of food intake and cause of death, but there was a preponderance of positive rank correlations for alcohol. This, together with similarities of age distributions of alcohol intake and death rates for causes related to alcohol, suggested the hypothesis that alcohol was associated with increased mortality. Other than this, because of the limited power of the exploratory statistical procedures applied, the hypothesis that there were health differences in people eating different foods could be neither accepted nor rejected.
JF  - Regulatory Toxicology and Pharmacology
AU  - Wagstaff, D J
AU  - Graves, C G
AU  - Ruddell, J H
AD  - Epidemiol. and Clin. Toxicol. Unit, Cent. Food Saf. and Appl. Nutr., FDA, Washington, DC 20204, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 149
EP  - 159
VL  - 7
IS  - 2
SN  - 0273-2300, 0273-2300
KW  - correlation
KW  - food intake
KW  - man
KW  - foods
KW  - ethanol
KW  - alcohol
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - toxicology
KW  - mortality
KW  - H SE4.27:FOOD PROCESSING INDUSTRIES
KW  - X 24120:Food, additives & contaminants
KW  - X 24180:Social poisons & drug abuse
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Food+intake+and+mortality+in+the+United+States.&rft.au=Wagstaff%2C+D+J%3BGraves%2C+C+G%3BRuddell%2C+J+H&rft.aulast=Wagstaff&rft.aufirst=D&rft.date=1987-01-01&rft.volume=7&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mortality; ethanol; toxicology; alcohol; food intake; man
ER  - 



TY  - CONF
T1  - Minutes from the fur-bearing animals and honey bee workshop session.
AN  - 14799982; 1653733
AB  - The session opened with a review of the status of IR-4 active projects; currently, the only active project listed for fur-bearing animals is being conducted in rabbits. A list of drug priorities was reviewed. In regard to the list for rabbits, pasteurellosis, is still a major disease. Coccidiosis is also ranked as a major disease in rabbits. The drug listing for mink and foxes was discussed. Difficulty has been experienced in finding drug companies to support labeling of products for use in bees. Alternatives to flumigillin and terramycin are needed, as well as entities to control fungal diseases and parasitic mites in honeybees. The list of biologicals was prioritized. Biological products for pasteurellosis in rabbits would have a high priority.
JF  - Veterinary and Human Toxicology
AU  - Smith, M M
Y1  - 1987
PY  - 1987
DA  - 1987
VL  - 29
KW  - fur-bearing
KW  - rabbits
KW  - mink
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology
KW  - coccidiosis
KW  - vaccines
KW  - animals
KW  - drugs
KW  - pasteurellosis
KW  - Pasteurella
KW  - Apis mellifera
KW  - conferences
KW  - Vulpes
KW  - J 02862:Infection
KW  - K 03091:Protozoa: animal
KW  - K 03088:Fungi: animal
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Epidemiological-environmental study of diesel bus garage workers: Chronic effects of diesel exhaust on the respiratory system.
AN  - 14798895; 1651260
AB  - Two hundred and eighty-three (283) male diesel bus garage workers from four garage in two cities were examined to determine if there was excess chronic respiratory morbidity related to diesel exposure. Exposure-effect relationships within the study population showed no detectable associations of symptoms with tenure. There was an apparent association of pulmonary function and tenure. Seven workers (2.5%) had category 1 pneumoconiosis (three rounded opacities, two irregular opacities, and one with both rounded and irregular). The study population was also compared to a nonexposed "blue-collar" population. After indirect adjustment for age, race, and smoking, the study population had elevated prevalences of cough, phlegm, and wheezing, but there was no association with tenure. Dyspnea showed a dose-response trend but no apparent increase in prevalence.
JF  - Environmental Research
AU  - Gamble, J
AU  - Jones, W
AU  - Minshall, S
AD  - NIOSH, Appalachian Lab. Occup. Saf. and Health, Div. Respir. Dis. Stud., 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 6
EP  - 17
VL  - 44
IS  - 1
SN  - 0013-9351, 0013-9351
KW  - diesel
KW  - exhaust
KW  - effects on
KW  - respiratory systems
KW  - man
KW  - occupational health
KW  - exhaust emissions
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - respiratory system
KW  - oil
KW  - occupational exposure
KW  - epidemiology
KW  - fuels
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - H ST2.26:EMISSIONS AND EMISSION CONTROL
KW  - H SM9.8.2:CHEMICALS (CORROSION)
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - oil; fuels; epidemiology; occupational exposure; respiratory system; occupational health; exhaust emissions; man
ER  - 



TY  - JOUR
T1  - Occupational exposure to 1,3-dichloropropene (Telone II) in Hawaiian pineapple culture.
AN  - 14798137; 1651148
AB  - 1,3-Dichloropropene (DCP), the primary constituent of Telone II, is a subsoil fumigant that has supplanted 1,2-dibromo-3-chloropropane (DBCP) and ethylene dibromide (EDB) as primary fumigant in Hawaiian pineapple culture. To determine the potential for adverse health effects, an environmental survey was done to assess worker exposures. Exposures were predominantly below 1 ppm, which is the no-effect level determined with experimental animals, and the Threshold Limit Value (TLV) recommended by the American Conference of Governmental Industrial Hygienists (ACGIH).
JF  - Archives of Environmental Health
AU  - Albrecht, W N
AD  - Hazard Eval. and Tech. Assist. Branch, U.S. DHHS, NIOSH, Robert A Taft Lab., R-10, 4676 Columbia Pky., Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 286
EP  - 291
VL  - 42
IS  - 5
SN  - 0003-9896, 0003-9896
KW  - workers
KW  - 1,3-dichloropropene
KW  - man
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - fumigation
KW  - surveys
KW  - occupational exposure
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24136:Environmental impact
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; fumigation; surveys; occupational health; man
ER  - 



TY  - JOUR
T1  - Mutagenicity assessment of airborne particles from three polyurethane foam manufacturing facilities.
AN  - 14797456; 1650865
AB  - In conjunction with industrial hygiene surveys, mutagenicity studies were performed for the airborne contaminants in three polyurethane manufacturing plants. Airborne particles were collected on glass-fiber filters with Hi-Vol pumps from different locations in each plant. Gases were collected in multiple-sorbent cartridges. The collected airborne particles and sorbent cartridges were extracted with organic solvents. Each extract was tested for mutagenic activity using Salmonella typhimurium TA98 and TA100. The results showed that airborne particles from all three plants are mutagenic to TA98 with or without S9 activation. The mutagenicity with S9, however, was two to four times higher than that without S9. None of the samples of gases collected on sorbent cartridges showed mutagenic activity.
JF  - American Journal of Industrial Medicine
AU  - Ong, T
AU  - Stewart, J
AU  - Whong, W-Z
AU  - Boeniger, M
AD  - NIOSH, Microbiol. Sect., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 475
EP  - 483
VL  - 11
IS  - 4
SN  - 0271-3586, 0271-3586
KW  - polyurethan
KW  - airborne particulates
KW  - particulates
KW  - manufacturing industry
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - mutagenicity
KW  - mutagens
KW  - Ames test
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - H SM5.8.2:CHEMICALS (CORROSION)
KW  - X 24155:Biochemistry
KW  - P 0000:AIR POLLUTION
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SI8.8.2:CHEMICALS (CORROSION)
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Ames test; mutagenicity; particulates; mutagens; manufacturing industry; occupational health; airborne particulates
ER  - 



TY  - JOUR
T1  - 4,4'-Methylenebis (2-chloroaniline): An unregulated carcinogen.
AN  - 14796149; 1651458
AB  - 4.4'-Methylenebis (2-chloroaniline) (MBOCA) is a confirmed animal carcinogen. It is used commercially as a curing agent for polymers containing isocyanate. There are no adequate studies documenting a carcinogenic risk for MBOCA in humans; however, studies in rats and dogs have shown that MBOCA is a carcinogen. Also, MBOCA is structurally similar to aromatic amines, which cause bladder cancer in workers with occupational exposure. Manufacture of MBOCA in the United States ceased in 1979. However, estimates of the number of workers potentially exposed range from 1,400 to 33,000 in the manufacture of MBOCA-cured products. Presently, there are no federal regulations limiting occupational exposure to MBOCA. In this paper, the authors review the literature in regard to MBOCA's carcinogenicity, describe industrial use and extent of worker exposure, and review MBOCA's status in relation to occupational regulations in the United States and abroad.
JF  - American Journal of Industrial Medicine
AU  - Ward, E
AU  - Smith, AB
AU  - Halperin, W
AD  - NIOSH, Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 537
EP  - 549
VL  - 12
IS  - 5
SN  - 0271-3586, 0271-3586
KW  - 4,4'-methylenebis (2-chloroaniline)
KW  - man
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - carcinogenicity
KW  - carcinogenesis
KW  - occupational exposure
KW  - reviews
KW  - H SE4.20:POISONS AND POISONING
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - carcinogenicity; occupational exposure; reviews; carcinogenesis; occupational health; man
ER  - 



TY  - JOUR
T1  - Toxicology and hazard assessment of 1,3-dichloropropene (Telone II).
AN  - 14791906; 1651176
AB  - Potential adverse health effects from occupational exposure to 1.3-dichloropropene (DCP) are reviewed and hazards assessed. Further toxicologic evaluations should be conducted using only high-purity material that is free from possibly confounding impurities and stablizers. Safety considerations when handling the material are included.
JF  - Archives of Environmental Health
AU  - Albrecht, W N
AD  - Hazard Eval. and Tech. Assist. Branch, U.S. DHHS, NIOSH, Robert A. Taft Lab. R-10, 4676 Columbia Pky., Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 292
EP  - 296
VL  - 42
IS  - 5
SN  - 0003-9896, 0003-9896
KW  - 1,3-dichloropropene
KW  - man
KW  - environmental medicine
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - reviews
KW  - toxicity
KW  - occupational exposure
KW  - X 24134:Pathology
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14791906?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Health&rft.atitle=Toxicology+and+hazard+assessment+of+1%2C3-dichloropropene+%28Telone+II%29.&rft.au=Albrecht%2C+W+N&rft.aulast=Albrecht&rft.aufirst=W&rft.date=1987-01-01&rft.volume=42&rft.issue=5&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Health&rft.issn=00039896&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - toxicity; occupational exposure; reviews; occupational health; man
ER  - 



TY  - CONF
T1  - Potential applications of pharmacokinetics toward minor species-use approvals: Human food safety.
AN  - 14791375; 1653683
AB  - Pharmacokinetic studies may provide useful information in terms of drug disposition but there has not been enough basic work done to enable CVM to use pharmacokinetics to predict tissue residues and assign withdrawal periods. Much carefully controlled work would need to be conducted to determine the correlations between tissue residues and plasma concentrations for a single drug, for a class of drugs, for differing dose levels, and for extrapolations between species. Conducting good pharmacokinetic studies requires expertise in the area and is not simply a matter of taking blood samples and measuring levels of a drug. In addition, CVM has not established any criteria for determining which studies are adequate to define the relationship between plasma levels of a drug and tissue residues.
JF  - Veterinary and Human Toxicology
AU  - Juskevich, J C
Y1  - 1987
PY  - 1987
DA  - 1987
VL  - 29
KW  - pharmacokinetics
KW  - residues
KW  - Toxicology Abstracts
KW  - animals
KW  - safety
KW  - drugs
KW  - food
KW  - conferences
KW  - X 24120:Food, additives & contaminants
KW  - X 24230:Legislation & recommended standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Rapid determination of methyl mercury in fish and shellfish: Collaborative study.
AN  - 14789791; 1651651
AB  - A modification of the official AOAC method for determining methyl mercury in fish and shellfish was studied in 8 laboratories. Methyl mercury is isolated from homogenized, acetone-washed tissue by adding HCl and extracting into toluene the methyl mercuric chloride produced. The extract is analyzed for methyl mercuric chloride by electron capture gas chromatography. Collaborators determined methyl mercury in blind duplicate homogenates at 2 levels in tuna and at 1 level in swordfish and oysters. Collaborators also analyzed single homogenates of swordfish and oysters containing methyl mercury at a second level. Both fortified and unfortified tissues were analyzed. Methyl-bound mercury in the commodities ranged from 0.50 to 2.30 mu g Hg/g. Reproducibility coefficients of variation ranged from 4 to 15%. Accuracy, measured by comparison to reference values, ranged from 92 to 101%. Recovery from fortified homogenates ranged from 86 to 98%.
JF  - Journal of the Association of Official Analytical Chemists
AU  - Hight, S C
AD  - FDA, Div. Contam. Chem., Washington, DC 20204, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 667
EP  - 672
VL  - 70
IS  - 4
SN  - 0004-5756, 0004-5756
KW  - U.S. Food and Drug Adm.
KW  - contamination
KW  - detection
KW  - determination
KW  - dimethylmercury
KW  - food contamination
KW  - foods
KW  - human food
KW  - marine fish
KW  - methyl mercury
KW  - modified AOAC method
KW  - pollutant detection
KW  - residues
KW  - shellfish
KW  - Pollution Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts
KW  - Marine
KW  - Pisces
KW  - X 24120:Food, additives & contaminants
KW  - X 24222:Analytical procedures
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - Q1 08627:Food quality and standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2014-05-05
N1  - SubjectsTermNotLitGenreText - methyl mercury; shellfish; human food; marine fish; food contamination; residues; contamination; Pisces; Marine
ER  - 



TY  - PAT
T1  - Immortalized T-lymphocyte cell line for testing HTLV-III inactivation.
AN  - 14784040; 1639263
AU  - Mitsuya, H
AU  - Broder, S
PY  - 1987
IS  - US Patent 4,704,357
KW  - cell lines
KW  - cytopathogenesis
KW  - screening
KW  - acquired immune deficiency syndrome
KW  - bioassays
KW  - clones
KW  - drugs
KW  - human immunodeficiency virus
KW  - lymphocytes T
KW  - patents
KW  - retrovirus
KW  - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - W 30050:Patents
KW  - A 01114:Viruses
KW  - W 30507:Diagnostic
KW  - W 30330:Animals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/32; Int. Cl. C12N 5/00.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Simultaneous assessment of genetic and occupational risk factors.
AN  - 14782169; 1631404
AB  - In this analysis the medical and epidemiologic literature has been surveyed and the methods for assessing genetic and occupational risks in the same study have been identified and critiqued. Five major methodologic approaches have been identified: (1) adjustment for race, ethnicity, and sex; (2) case studies of occupational disease in geneticallly susceptible workers; (3) cross-sectional evaluations of the prevalence of disease among genetically differentiated groups; (4) case-control studies of the association of genetic characteristics and disease; and (5) family studies of disease aggregations. These approaches, in part, allow for controlling genetic factors or identifying susceptible genes or phenotype markers that may differentiate occupational populations according to risk. However in many of the studies evaluated, the methods used were not very powerful for detecting gene-occupation interactions.
JF  - J. OCCUP. MED.
AU  - Schulte, P A
AD  - Ind. Stud. Branch, Div. Surv., Hazard Eval. and Field Stud., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 884
EP  - 891
VL  - 29
IS  - 11
SN  - 0096-1736, 0096-1736
KW  - risks
KW  - occupational hazards
KW  - man
KW  - occupational health
KW  - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts
KW  - hazards
KW  - reviews
KW  - genetics
KW  - risk assessment
KW  - X 24250:Reviews
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SI0.3:HAZARD DETERMINATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - genetics; reviews; occupational health; risk assessment; hazards; occupational hazards; man
ER  - 



TY  - JOUR
T1  - Case example of wrist trauma in keyboard use.
AN  - 14774489; 1633124
AB  - Evidence of injury to the pisiform and dorsal sensory branch of the ulnar nerve in a video display terminal (VDT) operator is presented. The subject has performed data entry work via keyboard for 20 years and has the common habit of resting her wrist against the leading edge of the keyboard. Skin lesions have ben observed in other keyboard operators who similarly support their limbs. The opportunity for this type of trauma has gone unreported (and apparently unrecognised) in the ergonomics literature, which generally advocates wrist support to reduce upper extremity fatigue and improve wrist-hand posture. The present case study indicates a need for further evaluation of the dynamics of wrist rest use and of the design of support systems such that forces acting upon the wrist or palm can be controlled. Suggestions are offered in this regard.
JF  - Applied Ergonomics
AU  - Sauter, S L
AU  - Chapman, L J
AU  - Knutson, S J
AU  - Anderson, HA
AD  - NIOSH, Cincinnati, OH, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 183
EP  - 186
VL  - 18
IS  - 3
SN  - 0003-6870, 0003-6870
KW  - keyboards
KW  - video display terminals
KW  - fatigue
KW  - hand injuries
KW  - Health & Safety Science Abstracts
KW  - ergonomics
KW  - H SM9.24:HAND INJURIES
KW  - H SI10.7:HUMAN FACTORS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ergonomics
ER  - 



TY  - JOUR
T1  - The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part I. Exposure estimates.
AN  - 14767162; 1612254
AB  - The vermiculite ore and concentrate of a mine and mill near Libby, Montana, was contaminated with fibrous tremolite-actinolite. Of 599 fibers counted in eight airborne membrane filter samples, 96% had an aspect ratio greater than 10 and 16% had an aspect ratio greater than 50. Additionally, 73% of the fibers were longer than 10 mu m, 36% were longer than 20 mu m, and 10% were longer than 40 mu m. Estimates of exposure before 1964 in the dry mill were 168 fibers/cc for working areas, 182 fibers/cc for sweepers, 88 fibers/cc for skipping, and 13 fibers/cc for the quality control laboratory. In 1964-1971, exposure estimates for these areas were 33, 36 17, and 3 fibers/cc, respectively. Estimates of exposures in the mine before 1971 ranged from 9-23 fibers/cc for drillers and were less than 2 fibers/cc for nondrilling jobs. All 8-hr TWA job exposure estimates decreased from 1972-1976, and from 1977-1982 were less than 1 fiber/cc.
JF  - American Journal of Industrial Medicine
AU  - Amandus, HE
AU  - Wheeler, R
AU  - Jankovic, J
AU  - Tucker, J
AD  - Div. Respir. Dis. Studies, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 1
EP  - 14
VL  - 11
IS  - 1
SN  - 0271-3586, 0271-3586
KW  - tremolite
KW  - actinolite
KW  - man
KW  - occupational health
KW  - asbestos
KW  - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts
KW  - morbidity
KW  - occupational exposure
KW  - mortality
KW  - risk assessment
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SI2.22:MINERALS INDUSTRIES
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; morbidity; mortality; occupational health; risk assessment; asbestos; man
ER  - 



TY  - JOUR
T1  - The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part III. Radiographic findings.
AN  - 14765706; 1612201
AB  - A study was conducted to estimate the exposure-response relationship for tremolite-actinolite fiber exposure and radiographic findings among 184 men employed at a Montana vermiculite mine and mill. Workers were included if they had been employed during 1975-1982 and had achieved at least 5 years tenure at the Montana site. Past fiber exposure was associated with an increased prevalence of parenchymal and pleural radiographic abnormalities. Smoking was not significantly related to the prevalence of small opacities. However, the number of workers who had never smoked was small, and this prevented measurement of the smoking effect. Under control for smoking and age, the prevalence of small opacities was significantly greater for vermiculite workers with greater than 100 fiber/cc-years exposure than for comparison groups (cement workers, blue collar workers, and coal miners) who had no known occupational fiber exposure.
JF  - American Journal of Industrial Medicine
AU  - Amandus, HE
AU  - Althouse, R
AU  - Morgan, WKC
AU  - Sargent, EN
AU  - Jones, R
AD  - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 27
EP  - 37
VL  - 11
IS  - 1
SN  - 0271-3586, 0271-3586
KW  - tremolite
KW  - actinolite
KW  - man
KW  - occupational health
KW  - asbestos
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - radiology
KW  - morbidity
KW  - occupational exposure
KW  - radiography
KW  - mortality
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - H SI2.22:MINERALS INDUSTRIES
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; radiography; mortality; morbidity; occupational health; radiology; asbestos; man
ER  - 



TY  - JOUR
T1  - Immunological activities of recombinant interferon- alpha sub(2) and its A fragment.
AN  - 14764439; 1624372
AB  - The immunomodulating effects of the A fragment of recombinant human interferon- alpha sub(2) (rIFN- alpha sub(2)) generated by thermolysin treatment was compared to that of the intact rIFN- alpha sub(2) and lymphoblastoid IFN. The A fragment was similar to intact IFN in augmenting natural killer (NK) activity and suppressing the proliferation of certain cell lines, but it failed to inhibit human polyclonal immunoglobulin production; rIFN- alpha sub(2) and lymphoblastoid IFN were equally effective in suppressing this in vitro system. These data suggest that the A fragment mediates certain, but not all, of the immunomodulating properties of IFN- alpha sub(2).
JF  - Journal of Interferon & Cytokine Research
AU  - Attallah, A M
AU  - Eleisher, T A
AU  - Hu, R
AU  - Abdel-Gaffar, H
AU  - Ibrahim, S
AU  - Metwali, A
AU  - Zoon, K
AD  - Off. Biol. Res. and Rev., Cent. Drugs and Biol., FDA, Bethesda, MD 20892, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 223
EP  - 229
VL  - 7
IS  - 2
SN  - 0197-8357, 0197-8357
KW  - recombinants
KW  - fragments
KW  - alpha -interferon
KW  - cell proliferation
KW  - immunostimulation
KW  - immunosuppression
KW  - natural killer cells
KW  - Biotechnology and Bioengineering Abstracts; Immunology Abstracts
KW  - F 06773:Interferons
KW  - W 30403:Interferon
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - alpha -interferon; immunostimulation; natural killer cells; immunosuppression; cell proliferation
ER  - 



TY  - JOUR
T1  - The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part II. Mortality.
AN  - 14761059; 1612229
AB  - The vermiculite ore and concentrate of a mine and mill located near Libby, Montana was found to be contaminated with a fiber of the tremolite/actinolite series. A study was conducted to estimate the exposure-response relationship for mortality for 575 men who had been hired prior to 1970 and employed at least 1 year at the Montana site. Individual cumulative fiber exposure (fiber-years) was calculated. Results indicated that mortality from nonmalignant respiratory disease (NMRD) and lung cancer was significantly increased compared to the U.S. white male population.
JF  - American Journal of Industrial Medicine
AU  - Amandus, HE
AU  - Wheeler, R
AD  - Div. Respir. Dis. Stud., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 15
EP  - 26
VL  - 11
IS  - 1
SN  - 0271-3586, 0271-3586
KW  - risks
KW  - tremolite
KW  - actinolite
KW  - carcinoma
KW  - man
KW  - occupational health
KW  - asbestos
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - occupational exposure
KW  - lung
KW  - mortality
KW  - risk assessment
KW  - cancer
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - H SI2.22:MINERALS INDUSTRIES
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; lung; mortality; cancer; occupational health; risk assessment; asbestos; carcinoma; man
ER  - 



TY  - JOUR
T1  - Polymer-fume fever associated with smoking and use of a mold-release spray containing polytetrafluoroethylene.
AN  - 14748914; 1612166
AB  - An ephemeral and debilitating flu-like illness experienced by stamp-makers prompted them to solicit assistance from the National Institute for Occupational Safety and Health. It was determined that a combination of the use of a mold-release spray containing a fluorocarbon polymer (polytetrafluoroethylene), poor general hygiene, and smoking during and after use of the spray was responsible for the workers' symptoms, commonly referred to as "polymer-fume fever." Recommendations made, and which resulted in the abatement of illness included: ventilating the vulcanizing furnace, cessation of smoking in the workplace, or using a mold-release spray that does not contain fluorocarbon.
JF  - J. OCCUP. MED.
AU  - Albrecht, W N
AU  - Bryant, C J
AD  - NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 817
EP  - 819
VL  - 29
IS  - 10
SN  - 0096-1736, 0096-1736
KW  - like
KW  - symptoms
KW  - polytef
KW  - influenza
KW  - man
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - fumes
KW  - smoking
KW  - polymers
KW  - occupational exposure
KW  - cigarettes
KW  - H SM10.31:INFLUENZA
KW  - X 24180:Social poisons & drug abuse
KW  - H SI0.8.1:FIRE & SMOKE
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - smoking; occupational exposure; cigarettes; occupational health; fumes; polymers; influenza; man
ER  - 



TY  - JOUR
T1  - The Case of the Missing Gene: Hereditary Protection Against Alcoholism
AN  - 1474329792
AB  - An ancient mystery solved by scientific detective work
JF  - Alcohol Health and Research World
AU  - STOIL, MICHAEL J
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 130
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Genetic Studies on Alcoholism at the NIAAA Intramural Laboratories
AN  - 1474329205
AB  - The search for linkages among known genes and unknown markers
JF  - Alcohol Health and Research World
AU  - Goldman, David
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 102
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474329205?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Readers' Exchange: The Alcoholism Treatment Client and Domestic Violence
AN  - 1474328145
JF  - Alcohol Health and Research World
AU  - Harner, Ivan C
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 150
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Effects on Future Generations of Paternal Exposure to Alcohol and Other Drugs
AN  - 1474327315
AB  - Can limited consumption by the father affect several generations?
JF  - Alcohol Health and Research World
AU  - Friedler, Gladys
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 126
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Out of the Darkness: Informing the Public About Inherited Vulnerability to Alcoholism
AN  - 1474327285
JF  - Alcohol Health and Research World
AU  - Casement, Mary R
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 114
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Beyond the Gene: Research Directions in Family Transmission of Susceptibility to Alcoholism
AN  - 1474326947
AB  - Remarks of a leading researcher on the complexity of the legacy
JF  - Alcohol Health and Research World
AU  - Reich, Theodore
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 104
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Occupational Arena
AN  - 1474326394
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 155
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 18: Positive Family History for Alcoholism
AN  - 1474326273
AB  - Results of a national survey
JF  - Alcohol Health and Research World
AU  - Harford, Thomas C
AU  - Haack, Mary R
AU  - Spiegler, Danielle L
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 138
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Implications for Intervention of Family History of Alcohol Abuse
AN  - 1474325158
JF  - Alcohol Health and Research World
AU  - Brown, Sandra A
AU  - Creamer, Vicki A
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 120
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Editor's Forum: Applying Information from Genetic Research in Intervention
AN  - 1474324875
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 108
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Drinker's Tail: Animal Genetics in Alcohol Research
AN  - 1474323872
AB  - Alcohol-consuming rodents offer clues on why humans drink
JF  - Alcohol Health and Research World
AU  - Deitrich, Richard A
AU  - Erwin, V Gene
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 98
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Genetic Paradigm: Implications for Research and Treatment
AN  - 1474323809
AB  - How genetics research may influence the alcoholism field
JF  - Alcohol Health and Research World
AU  - Gordis, Enoch
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 96
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474323633
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 154
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - "I Never Knew There Were So Many of Us": A Model Early Intervention Alcohol Program
AN  - 1474323615
JF  - Alcohol Health and Research World
AU  - Riddell, Alice M
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 110
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Special Populations: "Focus on Women"
AN  - 1474301219
JF  - Alcohol Health and Research World
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 157
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - International Perspectives: Drinking Patterns and the End of Cultural Isolation in Iceland
AN  - 1474301072
AB  - Research documents "globalization" of drinking
JF  - Alcohol Health and Research World
AU  - OLAFSDOTTIR, HILDIGUNNUR
Y1  - 1987///Winter
PY  - 1987
DA  - Winter 1987
SP  - 144
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 12
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Integration of safety and health into business and engineering school curricula.
AN  - 14734634; 1583566
AB  - The authors report on progress of two major NIOSH projects. Project Minerva represents a management approach to occupational safety and health in the workplace. Project Shape was initiated in 1980 to integrate safety and health into the curricula at approximately 300 engineering schools.
JF  - Professional Safety
AU  - Talty, J T
AU  - Walters, J B
AD  - Div. Train., Manpower Dep., NIOSH, Cincinnati, OH, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 26
EP  - 32
VL  - 32
IS  - 9
SN  - 0099-0027, 0099-0027
KW  - management
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - education
KW  - occupational health
KW  - H SI0.10:SAFETY EDUCATION, TRAINING, COMMUNICATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; occupational safety; education
ER  - 



TY  - JOUR
T1  - Spoilage of anchovy-stuffed olives by heterofermentative lactobacilli.
AN  - 14729188; 1583654
AB  - An unusual type of spoilage was encountered in canned green olives stuffed with anchovies. The spoilage was characterized by a gradual decrease in acidity of the olive brine from about pH 4.3 to 5.25 and a swelling of the cans caused by CO sub(2). Spoilage of the product was caused by decomposition of the anchovies by proteolytic enzyme action, with subsequent decarboxylation and deamination of amino acids from the anchovies by heterofermentative lactobacilli. This type of spoilage, known as "protein swells", occurs with canned fish marinades but, to the authors' knowledge, does not occur with other acidified canned foods.
JF  - Journal of Food Safety
AU  - Harmon, S M
AU  - Kautter, DA
AU  - McKee, C
AD  - FDA, Div. Microbiol., Washington, DC 20204, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 205
EP  - 210
VL  - 8
IS  - 3
SN  - 0149-6085, 0149-6085
KW  - canned food
KW  - spoilage
KW  - fish
KW  - foods
KW  - Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts
KW  - Engraulidae
KW  - Lactobacillus
KW  - seafood
KW  - H SE4.27:FOOD PROCESSING INDUSTRIES
KW  - X 24120:Food, additives & contaminants
KW  - X 24171:Microbial
KW  - A 01017:Human foods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Lactobacillus; Engraulidae; seafood; canned food; spoilage
ER  - 



TY  - JOUR
T1  - Cosmetic safety.
AN  - 14726243; 1583001
AB  - This report is clearly of an interim nature; much has been learned about cosmetic safety in recent years. Although the bulk of the data has been obtained from the historical approach, the authors hope that there will be fewer further toxicological disasters utilizing this approach. It is their belief that a clearly planned profile approach for each ingredient and formulation will decrease these risks in the years to come. The profile approach will continue to be more efficient and relevant when supported by more complete reporting of adverse experiences.
JF  - COSMETIC SCIENCE AND TECHNOLOGY SERIES. 1987.
AU  - Bronaugh, R L
AU  - Maibach, H I
AD  - Dermal and Ocul. Toxicol. Branch, FDA, Washington, DC 20204, USA
A2  - Whittam, JH (ed)
Y1  - 1987
PY  - 1987
DA  - 1987
SN  - 0887-6541, 0887-6541
KW  - cosmetics
KW  - cosmetics industry
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - reviews
KW  - safety
KW  - safety regulations
KW  - X 24140:Cosmetics, toiletries & household products
KW  - H SI6.23:COSMETIC INDUSTRIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14726243?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bronaugh%2C+R+L%3BMaibach%2C+H+I&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0824775384&rft.btitle=Cosmetic+safety.&rft.title=Cosmetic+safety.&rft.issn=08876541&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - safety; reviews; safety regulations; cosmetics industry; cosmetics
ER  - 



TY  - JOUR
T1  - Report on cancer risks associated with the ingestion of asbestos.
AN  - 14725705; 1573080
AB  - This report is an assessment of all available literature that pertains to the potential risk of cancer associated with ingestion of asbestos. It was compiled by a working group to assist policy makers in the Department of Health and Human Services determine if adequate information was available for a definitive risk assessment on this potential problem and evaluate if the weight of evidence was sufficient to prioritize this issue for new policy recommendations. The work group considered the basis for concern over this problem, the body of toxicology experiments, the individual epidemiologic studies which have attempted to investigate this issue, and the articles that discuss components of risk assessment pertaining to the ingestion of asbestos.
JF  - Environmental Health Perspectives
AU  - Lemen, R
AD  - Div. Stand. Dev. and Technol. Transfer, NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 253
EP  - 265
VL  - 72
SN  - 0091-6765, 0091-6765
KW  - risks
KW  - ingestion
KW  - carcinoma
KW  - man
KW  - asbestos
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - reviews
KW  - risk assessment
KW  - cancer
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14725705?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - asbestos; reviews; risk assessment; cancer; carcinoma; man
ER  - 



TY  - JOUR
T1  - Carcinogenic risk assessment: Comparison of estimated safe doses for rats and mice.
AN  - 14724056; 1573156
AB  - Data from the National Cancer Institute/National Toxicology Program (NCI/NTP) carcinogenesis bioassays were examined to compare cancer risks in rats and mice. Only those bioassays where chemicals were administered orally were used. The ratios for rats to mice of the virtually safe dose (VSD) levels associated with a risk of 10 super(-6) were compared. Comparisons of the ratios were made for those chemicals that NCI/NTP determined to be carcinogenic in at least one species and that showed a dose response trend in the same sex at the same tissue/organ site in the other species. In all, 69 comparisons from 38 carcinogens were performed. The overall geometric mean of the VSD ratios is 1.27 in terms of concentration (ppm). The VSD ratios vary from 1:51 to 49:1.
JF  - Environmental Health Perspectives
AU  - Chen, J J
AU  - Gaylor, D W
AD  - FDA/Biom., Natl. Cent. Toxicol. Res., Jefferson, AR 72079, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 305
EP  - 309
VL  - 72
SN  - 0091-6765, 0091-6765
KW  - comparison
KW  - risk assessment
KW  - estimate
KW  - rats
KW  - mice
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - carcinogenicity
KW  - chemicals
KW  - carcinogenesis
KW  - X 24221:Toxicity testing
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - carcinogenicity; chemicals; rats; mice; carcinogenesis; risk assessment
ER  - 



TY  - JOUR
T1  - Central nervous system toxicity of some common environmental residues in the mouse.
AN  - 14722444; 1584903
AB  - To ascertain changes in the level of general central nervous system (CNS) excitability and, therefore, postulated neurotoxicity of some common environmental residues, a bioassay was developed that used a known general CNS stimulant, pentylenetetrazol (PTZ, Metrazol). As a positive control, dieldrin was compared to PTZ and nine other compounds (caffeine, 1,2,3-trichloropropane, ethylene dibromide, Arochlor 1254, pentachlorophenol, heptachlor epoxide, DDT, lindane, and chlordecone) for CNS stimulatory effects, both acutely and subchronically. All doses were administered on an equimole per kilogram basis, rather than milligram per kilogram or %LD50 comparisons. The general level of CNS excitability elicited by each compound relative to the others was assessed. Of all compounds examined, dieldrin is concluded to have the greatest potential for causing an increase in general CNS excitability, which may relate to persistent behavioral stimulation.
JF  - Journal of Toxicology and Environmental Health
AU  - Albrecht, W N
AD  - Hazard Eval. and Tech. Assist. Branch, NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 405
EP  - 421
VL  - 21
IS  - 4
SN  - 0093-4108, 0093-4108
KW  - mice
KW  - Pollution Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts
KW  - neurotoxicity
KW  - central nervous system
KW  - toxicity
KW  - pesticides
KW  - toxicants
KW  - N3 11104:Mammals (except primates)
KW  - X 24132:Chronic exposure
KW  - X 24221:Toxicity testing
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - toxicants; central nervous system; toxicity; pesticides; mice; neurotoxicity
ER  - 



TY  - PAT
T1  - Adoptive immunotherapy as a treatment modality in humans.
AN  - 14710777; 1570257
AB  - A method of treating cancer in humans comprises systematically administering to a human suffering from cancer other than sarcomas, an effective amount of interleukin-2 and interleukin-2-activated autologous human lymphocytes to cause regression of said cancer.
AU  - Rosenberg, SA
PY  - 1987
IS  - US Patent 4,690,915
KW  - autologous mixed leukocyte reaction
KW  - carcinoma
KW  - immunotherapy
KW  - interleukin 2
KW  - man
KW  - patents
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30506:Therapeutic
KW  - W 30050:Patents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 514/2; Int. Cl. A61K 37/02,45/05.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Mortality of chrome leather tannery workers and chemical exposures in tanneries.
AN  - 14692032; 1545617
AB  - A retrospective mortality analysis was conducted in a cohort of 9,365 individuals employed as of 1940 in two chrome leather tanneries in the United States and followed to the end of 1982. Potential hazardous workplace exposures varied with department and included nitrosamines, chromate pigments, benzidine-based direct dyestuffs, formaldehyde, leather dust, and aromatic organic solvents. Mortality from all causes combined was lower than expected for each tannery, the standardized mortality ratio being 81 for one and 93 for the other. Deaths from cancer of each site, including the lung, were also lower than expected compared to those of either the population of the United States or of local state rates. A significant excess of deaths was observed, however, due to accidental causes in one tannery and cirrhosis of the liver, suicide, and alcoholism in the other. These excesses did not appear to be causally associated with occupational exposures.
JF  - Scandinavian Journal of Work, Environment & Health
AU  - Stern, F B
AU  - Beaumont, J J
AU  - Halperin, W E
AU  - Murthy, LI
AU  - Hills, B W
AU  - Fajen, J M
AD  - NIOSH, Robert A Taft Lab., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 108
EP  - 117
VL  - 13
IS  - 2
SN  - 0355-3140, 0355-3140
KW  - incidence
KW  - leather
KW  - chrome
KW  - man
KW  - tanning industry
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - diseases
KW  - mortality
KW  - industries
KW  - cancer
KW  - H SI2.29:TANNERIES
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14692032?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - industries; mortality; diseases; tanning industry; occupational health; cancer; leather; man
ER  - 



TY  - PAT
T1  - Water soluble derivatives of fredericamycin A.
AN  - 14685356; 1554700
AU  - Misra, R
PY  - 1987
IS  - US Patent 4,673,678
KW  - fredericamycin A
KW  - antibiotics
KW  - patents
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts
KW  - A 01013:Cytostatic & antitumor agents
KW  - W 30050:Patents
KW  - W 30410:Antibiotics and antitumor agents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 514/278; Int. Cl. A61K 31/435, C07D 221/18, A01N 43/42.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Lead content of foods stored in cans after opening.
AN  - 14685270; 1554692
AB  - A study was conducted of the effect on the concentration of lead in canned foods when they are stored in their lead-soldered cans after opening. Lead concentrations were periodically monitored during 5 days or 14 days after can opening. Fruit juices had the greatest increases in lead concentration during storage. Low-acid foods did not exhibit a significant increase in lead concentration. Recommendations against storing acidic foods and juices in their opened cans are supported by the results of the study.
JF  - Journal of Food Safety
AU  - Capar, S G
AU  - Loges, M
AD  - U.S. FDA, 200 C St., SW, Washington, DC 20204, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 187
EP  - 197
VL  - 8
IS  - 3
SN  - 0149-6085, 0149-6085
KW  - concentration
KW  - contamination
KW  - lead
KW  - heavy metals
KW  - food processing industry
KW  - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts
KW  - containers
KW  - food
KW  - storage
KW  - H SE4.27:FOOD PROCESSING INDUSTRIES
KW  - X 24120:Food, additives & contaminants
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - lead; food; containers; heavy metals; food processing industry; storage
ER  - 



TY  - JOUR
T1  - Retrospective cohort mortality study of dry cleaner workers using perchloroethylene.
AN  - 14680044; 1546155
AB  - To evaluate the carcinogenic potential from occupational exposure to perchloroethylene (PCE), a retrospective cohort mortality study of workers employed in the dry cleaning industry was conducted among 1,690 workers. The majority had potential exposure to petroleum solvents as well as to PCE. Mortality from primary cancer of the liver was of particular interest, due to the findings of excess liver cancer in mice exposed to PCE. Other sites of cancer were also of interest. A total of 493 deaths were observed, whereas 575.5 were expected. Mortality from all cancers combined was greater than expected (142 observed v 122.9 expected). No deaths due to liver cancer were observed. Urinary tract cancer was the only specific site where there was a statistically significant excess in observed deaths (12 observed v 4.7 expected).
JF  - J. OCCUP. MED.
AU  - Brown, D P
AU  - Kaplan, S D
AD  - Ind. Stud. Branch, Div. Surveillance, NIOSH, 4676 Columbia Parkway, Clincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 535
EP  - 541
VL  - 29
IS  - 6
SN  - 0096-1736, 0096-1736
KW  - man
KW  - perchloroethylene
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - carcinogenicity
KW  - carcinogenesis
KW  - occupational exposure
KW  - mortality
KW  - H SI6.8.2:CHEMICALS (CORROSION)
KW  - H SM6.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - perchloroethylene; carcinogenicity; occupational exposure; mortality; carcinogenesis; occupational health; man
ER  - 



TY  - JOUR
T1  - Aquatic versus mammalian toxicology: Applications of the comparative approach.
AN  - 14678318; 1545340
AB  - The large body of literature and techniques generated by mammalian toxicity studies provides a conceptual and technical framework within which the absorption, fate, and disposition of xenobiotics in aquatic organisms can be studied. This review emphasizes the similarities and differences between mammalian and aquatic systems, e.g., lung vs. gill as site of absorption and toxicity. These must be taken into consideration when designing aquatic toxicity studies. Studies of phenol red in dogfish shark (Scyliorhinus ) as an example show physiologic-based pharmacokinetic modeling to be a useful tool for investigating and eventually predicting species differences in xenobiotic disposition and drug differences within the same species. This discussion demonstrates that both laboratory and modeling procedures are now available to carry out sophisticated studies of xenobiotic fate and disposition in fish. Such studies are needed to pinpoint sites and mechanisms of pollutant toxicity in aquatic organisms.
JF  - Environmental Health Perspectives. 1987.
AU  - Guarino, A M
AD  - Fish. Res. Branch, FDA, P.O. Box 158, Dauphin Island, AL 36528, USA
A2  - Pritchard, JB (ed)
Y1  - 1987
PY  - 1987
DA  - 1987
SN  - 0091-6765, 0091-6765
KW  - absorption
KW  - animals
KW  - aquatic mammals
KW  - comparison
KW  - literature reviews
KW  - lung
KW  - marine mammals
KW  - reviews
KW  - xenobiotics
KW  - ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Toxicology Abstracts
KW  - Freshwater
KW  - bioaccumulation
KW  - toxicity
KW  - Marine
KW  - Scyliorhinus
KW  - Mammalia
KW  - toxicology
KW  - Brackish
KW  - gills
KW  - aquatic organisms
KW  - P 9000:ENVIRONMENTAL ACTION
KW  - Q5 08504:Effects on organisms
KW  - X 24250:Reviews
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Guarino%2C+A+M&rft.aulast=Guarino&rft.aufirst=A&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Aquatic+versus+mammalian+toxicology%3A+Applications+of+the+comparative+approach.&rft.title=Aquatic+versus+mammalian+toxicology%3A+Applications+of+the+comparative+approach.&rft.issn=00916765&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2014-05-05
N1  - SubjectsTermNotLitGenreText - aquatic mammals; aquatic organisms; toxicity; literature reviews; toxicology; marine mammals; gills; bioaccumulation; lung; reviews; animals; xenobiotics; Mammalia; Scyliorhinus; Marine; Brackish; Freshwater
ER  - 



TY  - JOUR
T1  - Epidemiological-environmental study of diesel bus garage workers: Acute effects of NO sub(2) and respirable particulate on the respiratory system.
AN  - 14674571; 1536992
AB  - Personal samples of nitrogen dioxide (NO sub(2)) and respirable particulate (RP) were collected over the shift on 232 workers in four diesel bus garages. Response was assessed by an acute respiratory questionnaire and before and after shift spirometry. Measures of exposure to NO sub(2) and RP were associated with work-related symptoms of cough; itching, burning, or watering eyes; difficult or labored breathing; chest tightness; and wheeze. The prevalence of burning eyes, headaches, difficult or labored breathing, nausea, and wheeze experienced at work were higher in the diesel bus garage workers than in a comparison population of battery workers, while the prevalence of headaches was reduced. Mean reductions in forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV sub(1)), peak flow, and flows at 50 and 75% of FVC were not obviously different from zero.
JF  - Environmental Research
AU  - Gamble, J
AU  - Jones, W
AU  - Minshall, S
AD  - NIOSH, Appalachian Lab. Occup. Saf. and Health, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 201
EP  - 214
VL  - 42
IS  - 1
SN  - 0013-9351, 0013-9351
KW  - effects on
KW  - particulate pollution
KW  - man
KW  - nitrogen dioxide
KW  - particulates
KW  - occupational health
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - occupational exposure
KW  - respiratory tract
KW  - X 24151:Acute exposure
KW  - H ST2.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Epidemiological-environmental+study+of+diesel+bus+garage+workers%3A+Acute+effects+of+NO+sub%282%29+and+respirable+particulate+on+the+respiratory+system.&rft.au=Gamble%2C+J%3BJones%2C+W%3BMinshall%2C+S&rft.aulast=Gamble&rft.aufirst=J&rft.date=1987-01-01&rft.volume=42&rft.issue=1&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - nitrogen dioxide; respiratory tract; occupational exposure; particulates; occupational health; particulate pollution; man
ER  - 



TY  - JOUR
T1  - A register-epidemiology study on cancer among Swedish printing industry workers.
AN  - 14673276; 1546906
AB  - The Swedish Cancer Environment Registry, a population-based Cancer Registry, has been supplemented with 1960 census data on occupation and industry. This information system was used to generate hypotheses on occupational high-cancer-risk groups and to discuss some methodological problems connected with register epidemiology. By successive exclusion of parts of the original population of printing industry workers with excess risks of lung and cervical cancer it was possible to consider similarities and differences between subgroups. Risk estimates from three different standardization methods agreed well for populations with more than 50 cases. Regional adjustment helped arrive at interpretable risk estimates.
JF  - Archives of Environmental Health
AU  - Malker, HSR
AU  - Gemne, G
AD  - NIOSH, Superv. Dep., Med. and Soc. Unit, Solna, Sweden
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 73
EP  - 82
VL  - 42
IS  - 2
SN  - 0003-9896, 0003-9896
KW  - Pollution Abstracts
KW  - risk assessment
KW  - epidemiology
KW  - printing industry
KW  - Cancer
KW  - Sweden
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Sweden; Cancer; epidemiology; risk assessment; printing industry
ER  - 



TY  - JOUR
T1  - Do safety and health programs pay for themselves?.
AN  - 14663425; 1531348
AB  - There's no question of a direct link between workers' compensation insurance costs and safety and health programs.
JF  - Ohio Monitor
AU  - Ault, R
AD  - Div. Saf. Hyg., NIOSH, Youngstown, OH, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 12
EP  - 14
VL  - 60
IS  - 3
KW  - compensation
KW  - insurance
KW  - Health & Safety Science Abstracts
KW  - economics
KW  - occupational health
KW  - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14663425?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - economics; occupational health
ER  - 



TY  - JOUR
T1  - Surveillance of work-related cold injuries using workers' compensation claims.
AN  - 14658970; 1531175
AB  - The usefulness of workers' compensation claim for the surveillance of occupational injuries was evaluated by analyzing claims for cold injury. Five hundred ten claims filed in 1983 from 23 states participating in the Bureau of Labor Statistics Supplementary Data System and an additional 147 claims filed with the Division of Safety and Hygiene of the Industrial Commission of Ohio from Jan 1, 1984, to June 30, 1985, were examined.
JF  - J. OCCUP. MED.
AU  - Sinks, T
AU  - Mathias, T
AU  - Halperin, W
AU  - Timbrook, C
AU  - Newman, S
AD  - DHHS PHS CDC, NIOSH, Robert A. Taft Lab. R-10, 4676 Columbia Parkw. Cincinnati, OH 45226-1998, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 504
EP  - 509
VL  - 29
IS  - 6
SN  - 0096-1736, 0096-1736
KW  - cold
KW  - compensation
KW  - Health & Safety Science Abstracts
KW  - data collection
KW  - occupational health
KW  - thermodynamics
KW  - H SI0.9.3:COLD
KW  - H SM6.9.3:COLD
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; thermodynamics; data collection
ER  - 



TY  - JOUR
T1  - Put a padlock on hazardous-release-of-energy injuries.
AN  - 14651231; 1531146
AB  - Lockout/tag-out procedures coupled with proper training can dramatically reduce the number of injuries resulting from the hazardous release of energy.
JF  - Ohio Monitor
AU  - Williams, M
AD  - Res. and Stat., Div. Saf. and Hyg., NIOSH, Cleveland, OH, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 8
EP  - 11
VL  - 60
IS  - 3
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - chemicals
KW  - training
KW  - hazards
KW  - energy
KW  - thermodynamics
KW  - H SI6.3:HAZARD DETERMINATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational safety; energy; hazards; thermodynamics; chemicals; training
ER  - 



TY  - JOUR
T1  - Quantitative risk assessment of lung cancer in U.S. uranium miners.
AN  - 14649238; 1530727
AB  - The National Institute for Occupational Safety and Health (NIOSH) has recently updated the vital status of the U.S. cohort of U miners through the end of 1982. This represents 69 additional lung cancer deaths since the last published follow-up through 1977. This more recent data was used to generate quantitative risk estimates of lung cancer after exposure to Rn daughters. Relative risks were estimated through use of the Cox proportional hazards model with an internal referent group. Results indicated that the exposure-response relationship was a slightly convex curve, predicting excess relative risk between 0.9 and 1.4 per 100 working level months (WLM) in the lower cumulative exposure range. Other findings of interest include a significant exposure-rate effect with low exposure rates more harmful per unit of cumulative exposure (WLM). Two temporal effects which modify relative risk estimates were also found. Relative risk increased with age at initial exposure to underground U mining. However, relative risk of lung cancer fell dramatically in the years following cessation of exposure.
JF  - Health Physics
AU  - Hornung, R W
AU  - Meinhardt, T J
AD  - NIOSH, Cent. Dis. Control, Cincinnati, OH 45226, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 417
EP  - 430
VL  - 52
IS  - 4
SN  - 0017-9078, 0017-9078
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - mining
KW  - occupational health
KW  - lung
KW  - risk assessment
KW  - uranium
KW  - cancer
KW  - P 8000:RADIATION
KW  - H SI2.9.1:RADIATION HAZARDS
KW  - H SM6.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - risk assessment; occupational health; uranium; mining; lung; cancer
ER  - 



TY  - JOUR
T1  - Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat.
AN  - 14637369; 1506121
AB  - The effect of pair feeding of euthyroid rats compared with propylthiouracil (PTU) treated rats on acetaminophen (APAP)-induced hepatotoxicity was studied. Pair feeding decreased both protein and energy intake compared with ad libitum-fed controls and resulted in decreased growth rate similar to that for the PTU treated rats. In contrast to the protective effect of PTU pretreatment, decreased protein energy intake by the euthyroid rats either tended to make them more susceptible to acetaminophen-induced hepatotoxicity or had no effect as assessed by elevation of serum transaminases (SGOT-SGPT) and by hepatic necrotic score. Pair feeding also significantly altered drug disposition with an increase in the molar ratio of urinary APAP-mercapturic acid conjugate, but not the absolute amount, suggesting possible increased cytochrome P-450 dependent drug metabolizing enzyme activity. Compared with PTU-fed, in the pair-fed the molar ratio of glucuronide conjugate decreased and sulfate conjugate increased.
JF  - DRUG-NUTR. INTERACTIONS.
AU  - Raheja, K L
AU  - Cho, C
AU  - Hirose, N
AD  - FDA, HFN-810, Rm. 14B-19, 5600 Fishers Lane, Rockville, MD 20857, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 21
EP  - 31
VL  - 5
IS  - 1
KW  - toxicity
KW  - propylthiouracil
KW  - acetaminophen
KW  - rats
KW  - Toxicology Abstracts
KW  - nutrition
KW  - analgesics
KW  - liver
KW  - X 24111:Acute exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - nutrition; liver; analgesics
ER  - 



TY  - JOUR
T1  - Workers/rescuers continue to die in confined spaces.
AN  - 14601831; 1475478
AB  - Fatalities and serious injuries continue to occur in confined spaces in a number of industries, including the wastewater treatment industry. Fatal incidents investigated by NIOSH reveal two major factors which lead to this needless loss of life: 1) failure to recognize the hazards associated with confined spaces, and 2) incorrect emergency response. As part of a study of occupational fatalities, NIOSH has investigated five separate fatal incidents in confined spaces involving wastewater treatment and sewage systems. The following cases are presented to point out some of the factors which led to worker deaths, and some of the methods by which these tragic deaths could have been prevented.
JF  - Professional Safety
AU  - Pettit, T A
AU  - Sanderson, L M
AU  - Linn, H I
AD  - NIOSH, Div. Saf. Res., Morgantown, WV, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 15
EP  - 22
VL  - 32
IS  - 2
SN  - 0099-0027, 0099-0027
KW  - confined spaces
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational safety
KW  - wastewater treatment
KW  - accidents
KW  - mortality
KW  - H SI0.4:ACCIDENT INVESTIGATION
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Safety&rft.atitle=Workers%2Frescuers+continue+to+die+in+confined+spaces.&rft.au=Pettit%2C+T+A%3BSanderson%2C+L+M%3BLinn%2C+H+I&rft.aulast=Pettit&rft.aufirst=T&rft.date=1987-01-01&rft.volume=32&rft.issue=2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Professional+Safety&rft.issn=00990027&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational safety; accidents; mortality; wastewater treatment
ER  - 



TY  - JOUR
T1  - Working with cold: Injuries in the workplace.
AN  - 14542360; 1431434
AB  - In this article the authors will examine injuries caused by exposure to cold and demonstrate that these injuries are not uncommon in the workplace, that some workers are more likely to suffer a cold-related injury than others, and that these injuries occur in a predictable pattern and are therefore avoidable. Finally, they will review methods to prevent injury when exposure to cold is inevitable.
JF  - Ohio Monitor
AU  - Sinks, T
AD  - Div. Surveill., Hazard Eval. and Field Stud., NIOSH, Cincinnati, OH, USA
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 12
EP  - 15
VL  - 60
IS  - 1
KW  - hypothermia
KW  - Health & Safety Science Abstracts
KW  - physiology
KW  - ergonomics
KW  - occupational health
KW  - H SI0.9.3:COLD
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14542360?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; ergonomics; physiology
ER  - 



TY  - JOUR
T1  - Radioimmunoassay of paralytic shellfish toxins in clams and mussels
AN  - 13805553; S198822967
AB  - The mouse bioassay, high-performance liquid chromatography, and a recently developed radioimmunoassay were compared for determination of paralytic shellfish poisons in extracts of shellfish from coastal waters of Maine and Connecticut. The new immunoassay method showed promise as a screening method for paralytic shellfish toxins. Further studies to validate this technique were planned.
JF  - Bulletin of Environmental Contamination and Toxicology
AU  - Yang, G C
AU  - Imagire, S J
AU  - Yasaei, P
AU  - Ragelis, E P
AU  - Park, D L
AU  - Page, S W
AU  - Carlson, R E
AU  - Guire, P E
AD  - U.S. Food and Drug Administration, Washington, D.C.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 264
EP  - 271
VL  - 39
IS  - 2
SN  - 0007-4861, 0007-4861
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Effects of chemical structure and exposure on the microbial degradation of polycyclic aromatic hydrocarbons in freshwater and estuarine ecosystems
AN  - 13803838; 198704699
AB  - Eight-week experiments studied the microbial degradation of hexadecane and 6 representative 2-5 ring polycyclic aromatic hydrocarbons (PAHs) in three multicomponent microcosms containing sediment and water from DeGray reservoir (pristine, freshwater), Chicot lake (freshwater, chronically exposed to agricultural pesticides and herbicides), or Redfish bay (estuarine water, chronically exposed to petrogenic hydrocarbons). Estimated half lives for hexadecane, naphthalene, 2-methylnaphthalene, pyrene, 3-methycholanthrene and benzo(a)pyrene, respectively, were 2.2-4.2, 2.4-4.4, 4-18, 14-20, 34-90, 87-over 200, and 200-over 300 weeks, demonstrating how differences in chemical size and structure could affect degradation rates. Degradation was fastest in the Redfish microcosm, and slowest in the DeGray microcosm. Analysis showed that Redfish bay sediment contained large populations of hydrocarbon-degrading bacteria whereas, though the Chicot lake sediment contained large numbers of heterotrophs, not all were able to utilize PAHs. Extractable polar metabolites, detected in water and sediment, accounted from 0.1-6 per cent of the original PAHs.
JF  - Environmental Toxicology and Chemistry
AU  - Heitkamp, MA
AU  - Cerniglia, CE
AD  - National Centre for Toxicological Research, FDA, Jefferson, Ark.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 535
EP  - 546
VL  - 6
IS  - 7
SN  - 0730-7268, 0730-7268
KW  - Hexadecane
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Rapid determination of methyl mercury in fish and shellfish: method development
AN  - 13802000; 198703267
AB  - The U.S. Association of Official Analytical Chemists (AOAC) official method for the determination of methyl mercury in fish and shellfish was modified to achieve a more rapid determination. Methylmercuric chloride was extracted from homogenized, acetone-washed, acid-digested (hydrochloric acid) fish tissue using toluene. Toluene extracts were then analysed by gas chromatography with electron capture detection (GC-ECD) using a 5 per cent DEGS-PS column pretreated with mercuric chloride. Samples of swordfish, shark, shrimp, oysters, clams, and tuna were analysed for methyl mercury by both old and new AOAC methods and the AOAC method for total mercury. In addition, selected samples were analysed by GC with mercury selective microwave-induced helium plasma detection. The detection limit for the new method was 0.25 ug per g with no significant differences observed between the results of the various methods used.
JF  - Journal of Association of Official Analytical Chemists
AU  - Hight, S C
AU  - Corcoran, M T
AD  - Food and Drug Administration, Washington, D.C.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 24
EP  - 30
VL  - 70
IS  - 1
KW  - Analysis
KW  - Columns
KW  - Fish (see also individual groups listed below)
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Premature thelarche in Puerto Rico: a search for environmental oestrogenic contamination
AN  - 13792397; S198927285
AB  - In 1982, the Centres for Disease Control (Atlanta) began an investigation into possible causes of the increased incidence of premature thelarche (breast development in girls below the age of 8, without other signs of premature sexual development) in Puerto Rico. Three surveys were conducted. The first analysed samples of meat and milk from local grocery stores. The second survey, conducted in 14 households (8 patients, 6 controls), analysed serum, urine, food (from households and local markets) and water (from households, tap water stations and well-water sources). The third survey was conducted among 96 premature thelarche patients from the University Paediatric Hospital. A cytosol-receptor assay was used to screen meat, poultry, milk and water samples for oestrogenic activity. Water and serum samples were analysed for zearalanol and its derivatives, oestrodiol, follicle stimulating hormone, and luteinizing hormone. Four cases were presumptively positive for zearalanol, but there were some indications of interference, and insufficient sera to repeat the analysis. All other analyses failed to identify the presence of any oestrogenic activity or oestrogenic chemicals in test samples. The investigation was continuing.
JF  - Archives of Environmental Contamination and Toxicology
AU  - Hannon, W H
AU  - Hill, R H
AU  - Bernert, J T
AU  - Haddock, L
AU  - Lebron, G
AU  - Cordero, J F
AD  - U.S. Department of Health and Human Services, Atlanta, Ga.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 255
EP  - 262
VL  - 16
IS  - 3
SN  - 0090-4341, 0090-4341
KW  - Diseases (see also individual groups below)
KW  - Analysis
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Enumeration of faecal coliforms and E. coli in marine and estuarine waters: an alternative to the APHA-MPN approach
AN  - 13790849; 198800811
AB  - Tabulated results are presented from a study comparing the mTEC membrane-filtration technique and the APHA MPN procedure for enumerating faecal coliform bacteria and Escherichia coli in sea water and estuarine water. There was no statistically significant difference between the results obtained by the 2 methods, and it was concluded that the mTEC method was a suitable alternative to the MPN procedure. In addition, the mTEC method was more rapid, more precise, and less costly to carry out.
JF  - Journal of Water Pollution Control Federation
AU  - Rippey
AU  - Adams, W N
AU  - Watkins, W D
AD  - U.S. Food and Drug Administration, Davisville, R.I.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 795
EP  - 798
VL  - 59
IS  - 8
KW  - American public health association
KW  - Sea water (see also marine -----)
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Application.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Volatile halocarbon compounds in process water and processed foods
AN  - 13790009; 198800992
AB  - Volatile halogenated organic compounds had been detected in some processed foods and in groundwater in the U.S.A.; it was suggested that contamination of the foods resulted from the use of polluted process water. The process waters and finished products at 15 food processing plants in 9 states of the U.S.A., representing a total of 39 food products, were analysed for volatile halogenated organic compounds. Information on the plants investigated and the concentrations of volatile compounds found are tabulated. Only occasional low concentrations were found in water and foods even in plants located in areas where contamination was probable.
JF  - Bulletin of Environmental Contamination and Toxicology
AU  - Uhler, AD
AU  - Diachenko, G W
AD  - U.S. Food and Drug Administration, Washington, D.C.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 601
EP  - 607
VL  - 39
IS  - 4
SN  - 0007-4861, 0007-4861
KW  - Pollution (s/a contamination, individ grps below)
KW  - Analysis
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Determination of methylmercury in fish by gas chromatography-direct current plasma atomic emissions spectrometry
AN  - 13783168; S198927788
AB  - Details are given of equipment and procedure for determination of methylmercury in fish tissues, using gas chromatography interfaced simply and inexpensively with a direct current plasma atomic emissions spectrometer. Results obtained on swordfish samples by this and other methods are compared in a series of tables, and reasons for the differences between the methods are considered. An additional procedure for extraction of methylmercury with an organic solvent, followed by concentration and injection on to the gas-chromatographic column was developed; depending on the solvent, artefact formation of methylmercury could occur, and measures for avoiding this are suggested.
JF  - Analyst (London)
AU  - Panaro, K W
AU  - Erickson, D
AU  - Krull, I S
AD  - U.S. Food and Drug Administration, Boston, Mass.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 1097
EP  - 1105
VL  - 112
IS  - 8
SN  - 0003-2654, 0003-2654
KW  - Equipment
KW  - Fish (see also individual groups listed below)
KW  - Columns
KW  - Atomic
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Incidence of Vibrio cholerae from estuaries of the United States West Coast
AN  - 13783106; S198927770
AB  - Two hundred and sixty-one sites in California, Oregon and Washington were sampled in 1984. Shellfish, sediment and estuarine water samples from 24 estuaries all close to sources of pollution, were examined for faecal coliforms and Vibrio spp. V. cholerae non-01 was found in 23 estuaries and in 44.6 per cent of the 529 samples examined. V. cholerae 01 Inaba was isolated from water samples from Morro bay, Calif. V. mimicus was found in 2.3 per cent of the samples. Cholera enterotoxin was not found in cell free filtrates of the 100 isolates tested in the Y-1 mouse adrenal cell assay. Heat labile cytotoxic activity was observed with 3 per cent of the isolates.
JF  - Applied and Environmental Microbiology
AU  - Kaysner, CA
AU  - Abeyta, C
AU  - Wekell, M M
AU  - DePaola, A
AU  - Stott, R F
AU  - Leitch, J M
AD  - Food and Drug Administration, Seattle, Wash.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 1344
EP  - 1348
VL  - 53
IS  - 6
SN  - 0099-2240, 0099-2240
KW  - Pollution (s/a contamination, individ grps below)
KW  - 529
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Virulent strains of Vibrio vulnificus isolated from estuaries of the United States West Coast
AN  - 13782603; S198927771
AB  - Two hundred and sixty-one sites in California, Oregon and Washington were sampled in 1984. Five hundred and twenty-nine water, sediment and shellfish samples were examined for V. vulnificus. V. vulnificus was found in 5.9 per cent of the samples. Four strains tested with iron treated mice had a 50 per cent lethal dose value in the range 7.6-360 cfu. The presence of the pathogen might be a hazard to susceptible users of marine beaches and consumers of raw shellfish on the West Coast of America. Species-specific antiflagellar serum and a gene probe for cytotoxic-haemolysin production were useful for screening environmental isolates.
JF  - Applied and Environmental Microbiology
AU  - Kaysner, CA
AU  - Abeyta, C
AU  - Wekell, M M
AU  - DePaola, A
AU  - Stott, R F
AU  - Leitch, J M
AD  - Food and Drug Administration, Seattle, Wash.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 1349
EP  - 1351
VL  - 53
IS  - 6
SN  - 0099-2240, 0099-2240
KW  - Hazard
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Elevated temperature method for recovery of Vibrio cholerae from oysters (Crassostrea gigas)
AN  - 13780958; S198927487
AB  - Isolates from clinical and environmental sources were incubated in alkaline peptone broth at 42C. Two hundred and nineteen out of 222 V. cholerae isolates produced visible growth. Higher rates of isolation were obtained when samples from oysters were incubated at 42C instead of at 35C.
JF  - Applied and Environmental Microbiology
AU  - DePaola, A
AU  - Kaysner, CA
AU  - McPhearson, R M
AD  - Food and Drug Administration, Dauphin Island, Ala.
Y1  - 1987
PY  - 1987
DA  - 1987
SP  - 1181
EP  - 1182
VL  - 53
IS  - 5
SN  - 0099-2240, 0099-2240
KW  - Visibility
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - GEN
T1  - Standards & Criteria for the Development and Evaluation of a Comprehensive Employee Assistance Program.
AN  - 63251454; ED284133
AB  - This document was designed for use by persons or agencies interested in both establishing and evaluating employee assistance programs (EAP) for federal employees. It contains essential elements, standards, and assessment criteria which have been developed to assist in the planning and implementation of services, and to provide a framework for evaluating the appropriateness and effectiveness of EAPs. The standards and criteria presented here should also prove useful outside of the federal system. The introduction identifies the goal of an EAP as being the restoration of valuable employees to full productivity. It notes that a comprehensive EAP must address alcohol, drug abuse, and emotional or behavioral problems. The report lists five essential elements of an EAP: (1) needs assessment; (2) program integration; (3) comprehensive services; (4) program administration; and (5) program evaluation. For each element, a standard is defined which indicates what is expected when an organization seeks to provide that EAP element. To assist in the evaluation of programs, there are assessment criteria following each standard which relate to the policy, procedural, and personal and/or administrative aspects of a program. The appendices contain information on the legal authority for an EAP and models of providing EAP services. (NB)
Y1  - 1986/12//
PY  - 1986
DA  - December 1986
SP  - 21
KW  - ERIC, Resources in Education (RIE)
KW  - Human Services
KW  - Program Administration
KW  - Personnel Policy
KW  - Evaluation Criteria
KW  - Program Development
KW  - Standards
KW  - Program Evaluation
KW  - Organizational Objectives
KW  - Needs Assessment
KW  - Employee Assistance Programs
KW  - Self Evaluation (Groups)
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LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Synthesis and mutagenicity of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide, microsomal metabolites of 1-nitropyrene.
AN  - 77355079; 3331683
AB  - [4,5,9,10-(3)H]1-Nitropyrene was incubated with liver microsomes prepared from guinea pigs treated with Aroclor 1254 and the products were examined by h.p.l.c. The previously reported metabolites, 1-nitropyrene trans-4,5-dihydrodiol, 1-nitropyrene trans-9,10-dihydrodiol, and 3-, 6-, and 8-hydroxy-1-nitropyrene were detected. In addition, h.p.l.c., nuclear magnetic resonance and mass spectral analyses indicated the presence of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide. The epoxide hydrase inhibitor, 1,2-epoxy-3,3,3-trichloropropane, decreased the concentration of the 4,5- and 9,10-dihydrodiols in the microsomal incubations and increased the concentration of their corresponding oxides. Reaction of 1-nitropyrene with m-chloroperoxybenzoic acid gave a mixture of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide, which was separated by chromatography. The mutagenicity of the oxides was determined in Salmonella typhimurium strains TA98, TA98NR, and TA98/1,8-DNP6, both with and without exogenous activation by a rat liver homogenate fraction (S9). In the absence of S9, both oxides showed maximum activity in TA98, slightly decreased mutagenicity in the acetylase-deficient strain TA98/1,8-DNP6, and much reduced activity in the nitroreductase-deficient strain, TA98NR. When assayed in the presence of S9, 1-nitropyrene 4,5-oxide had maximum mutagenicity in TA98, and was 50 and 95% less mutagenic in TA98NR and TA98/1,8-DNP6, respectively. 1-Nitropyrene 9,10-oxide had a similar strain sensitivity, except that its total mutagenicity was lower. Since 1-nitropyrene is metabolized by oxidative pathways in vivo, these K-region oxides may contribute to the toxicities elicited by this compound.
JF  - Mutagenesis
AU  - Fifer, E K
AU  - Howard, P C
AU  - Heflich, R H
AU  - Beland, F A
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1986/11//
PY  - 1986
DA  - November 1986
SP  - 433
EP  - 438
VL  - 1
IS  - 6
SN  - 0267-8357, 0267-8357
KW  - Mutagens
KW  - 0
KW  - Pyrenes
KW  - 1-nitropyrene-4,5-oxide
KW  - 105596-42-7
KW  - 1-nitropyrene-9,10-oxide
KW  - 105596-43-8
KW  - Trichloroepoxypropane
KW  - 3083-23-6
KW  - Epoxide Hydrolases
KW  - EC 3.3.2.-
KW  - 1-nitropyrene
KW  - TD1665I8Q4
KW  - Index Medicus
KW  - Rats, Inbred Strains
KW  - Rats
KW  - Animals
KW  - Mutagenicity Tests -- methods
KW  - Guinea Pigs
KW  - Biotransformation
KW  - In Vitro Techniques
KW  - Spectrum Analysis -- methods
KW  - Salmonella typhimurium -- drug effects
KW  - Epoxide Hydrolases -- antagonists & inhibitors
KW  - Trichloroepoxypropane -- pharmacology
KW  - Male
KW  - Pyrenes -- toxicity
KW  - Mutagens -- metabolism
KW  - Microsomes, Liver -- metabolism
KW  - Pyrenes -- metabolism
KW  - Mutagens -- chemical synthesis
KW  - Pyrenes -- chemical synthesis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-12
N1  - Date created - 1988-10-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - RPRT
T1  - Report to Congress on an Analysis of Financial Disincentives to Career Choices in Health Professions.
AN  - 63242886; ED281424
AB  - Trends in expenses, financial assistance, and indebtedness for students studying health professions and the effects of financial considerations on career choice were examined. The objective was to determine financial disincentives to graduates of health professions schools that affect their choice of practice specialty or their decision to practice in an underserved area. Information that is needed to determine whether there are disincentives that affect the achievement of national health goals were also identified. The influence of economic factors on career choices of minority students was considered as well. The following health professions that are eligible for the Health Education Assistance Loan and/or the Health Professions Student Loan program were covered: medicine, osteopathic medicine, dentistry, veterinary medicine, optometry, podiatry, pharmacy, and public health. Additional loan and scholarship program awards were also considered. Data are provided by profession on the current status and recent trends in educational expenses (e.g., tuition, fees); mechanisms used by students to finance their education; debt levels; and trends in federal and nonfederal financial aid. Numerous tables and five pages of references are included. (SW)
AU  - Stambler, Howard V.
Y1  - 1986/11//
PY  - 1986
DA  - November 1986
SP  - 68
PB  - Health Resources and Services Administration, Bureau of Health Professions, Rockville, MD 20857.
KW  - Paying for College
KW  - ERIC, Resources in Education (RIE)
KW  - Geographic Location
KW  - Student Loan Programs
KW  - Loan Repayment
KW  - Podiatry
KW  - Specialization
KW  - Debt (Financial)
KW  - Higher Education
KW  - Public Policy
KW  - Incentives
KW  - Dentistry
KW  - Career Choice
KW  - Tuition
KW  - Health Occupations
KW  - Financial Problems
KW  - Student Financial Aid
KW  - Economic Factors
KW  - Public Health
KW  - Medicine
KW  - Labor Supply
KW  - Optometry
KW  - Student Costs
KW  - Pharmacy
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63242886?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - The 1990 Health Objectives for the Nation: A Midcourse Review.
AN  - 63158091; ED296989
AB  - With the release of "Healthy People: The Surgeon General's Report on Health Promotion and Disease Prevention" in 1979, the Public Health Service launched a decade-long initiative to reduce preventable death and disease in all age groups in the population by 1990. The 226 health objectives, issued in 1980, addressed measures to improve health status and reduce risks to health across 15 areas of mortality, morbidity, preventive interventions, and health-related behaviors. This report provides a status report on each of the 226 objectives, a commentary on that status, and a brief assessment of what will be needed to reach the 1990 target successfully. The report is in three sections: preventive services, health protection, and health promotion. (JD)
Y1  - 1986/11//
PY  - 1986
DA  - November 1986
SP  - 247
KW  - Health Promotion
KW  - ERIC, Resources in Education (RIE)
KW  - Birth
KW  - Health Needs
KW  - Public Health
KW  - Safety
KW  - Immunization Programs
KW  - Preventive Medicine
KW  - Social Problems
KW  - Health Education
KW  - Nutrition
KW  - Pregnancy
KW  - Drug Abuse
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63158091?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519945192
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519945192?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944968
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 1
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944968?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944316
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944316?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Solving the Legal Quandary in Recovery
AN  - 1474330180
AB  - Legal issues in recovery.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 40
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474330180?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Mystery of Craving
AN  - 1474327824
AB  - Research on that "seemingly irresistible urge."
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 12
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474327824?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=The+Mystery+of+Craving&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Recovery Without Treatment
AN  - 1474327548
AB  - Some people argue that formal treatment is unnecessary for them.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 24
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474327548?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Recovery+Without+Treatment&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Fitness and Recovery
AN  - 1474326757
AB  - Should physical fitness training be a part of a treatment and recovery program?
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 30
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474326757?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Fitness+and+Recovery&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Reversal of Alcohol Effects: "Acute and Chronic Conditions"
AN  - 1474326265
AB  - Which effects of alcohol are reversible? And when?
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 52
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474326265?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Reversal+of+Alcohol+Effects%3A+%22Acute+and+Chronic+Conditions%22&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Relapse Prevention Planning: "A New Recovery Tool"
AN  - 1474325974
AB  - The author discusses signs of relapse and models for preventing it.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474325974?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Relapse+Prevention+Planning%3A+%22A+New+Recovery+Tool%22&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Recovery - Beginning of a Beginning
AN  - 1474324003
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474324003?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 13: Trends in Alcohol-Related Fatal Traffic Accidents, United States, 1977-1984
AN  - 1474323750
AB  - Results from a surveillance report recently completed at the Alcohol Epidemiologic Data System.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 60
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474323750?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+13%3A+Trends+in+Alcohol-Related+Fatal+Traffic+Accidents%2C+United+States%2C+1977-1984&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-10-01&rft.volume=11&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Techniques for the Recovering Person To Use in Parenting
AN  - 1474323644
AB  - A neglected area in recovery?
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474323644?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Lifestyle Rehabilitation: "The Second Recovery Track"
AN  - 1474323623
AB  - Thoughts about addiction treatment and recovery.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474323623?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Back to Work: "Vocational Recovery"
AN  - 1474302780
AB  - Occupational stability as a major factor in maintaining sobriety.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 34
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474302780?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Issues Relevant to Aftercare Programs for Women
AN  - 1474302365
AB  - Women's recovery needs beyond treatment and initial sobriety.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 46
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474302365?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Recovery from Alcoholism: "Issues for Black and Native American Alcoholics"
AN  - 1474302160
AB  - Research into these special populations.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 42
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - News Notes
AN  - 1474301903
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 75
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Reader's Exchange
AN  - 1474301872
AB  - Caffeine Use in the Recovering Alcoholic
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 64
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Tool for Measuring Body and Behavioral Experiences
AN  - 1474301741
AB  - Investigating the nature of experiences in early recovery.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 26
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Problems in Predicting Recovery from Alcoholism
AN  - 1474301371
AB  - Isolating factors that will assess prospects for success.
JF  - Alcohol Health and Research World
Y1  - 1986///Fall
PY  - 1986
DA  - Fall 1986
SP  - 20
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 1
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - RPRT
T1  - CHEMICAL STOCKPILE DISPOSAL PROGRAM, ALABAMA, COLORADO, INDIANA, KENTUCKY, MARYLAND, OREGON, UTAH, AND POTENTIALLY TRAVERSED STATES.
AN  - 36387332; 904
AB  - PURPOSE: Destruction of the United States stockpile of unitary lethal chemical agents and munitions by September 30, 1994 is proposed. Four disposal alternatives are being considered: (1) on-site disposal at each of the existing storage installations; (2) transportation to regional disposal centers at Anniston Army Depot, Alabama and Tooele Army Depot (TEAD), Utah; (3) transportation to a national disposal center at TEAD; and (4) no action/continued storage. The chemical stockpile in the continental United States is currently stored at eight Army installations. Rail transportation has been selected by the Army for those alternatives requiring transport of the stockpile. The location will be determined by the EIS process. The Army would prefer to use high-temperature incineration for destruction purposes. POSITIVE IMPACTS: Destruction of the stockpile would reduce the period of time that people would be at risk. The Army plans to implement an intergovernmental consultation and coordination process to facilitate state and local government awareness of this program and a technical assistance program to improve emergency response capabilities of affected states and communities. NEGATIVE IMPACTS: Some adverse impacts are unavoidable regardless of the alternative selected; others are specific to a particular alternative and may vary qualitatively and quantitatively, depending on which alternative is selected. Some members of the public will be at risk for a period of a few years (all three disposal alternatives) to an indeterminate period of time (continued storage alternative). For the on-site disposal alternative, those persons currently at risk will continue to be at changing levels of risk for up to eight years (i.e., storage risk and then disposal risk). For continued storage, these same persons will continue to be at risk for a more extended period (i.e., the continued storage period). For the regional disposal centers and the national disposal center alternatives, additional people not now at risk will be at some risk during the move of the stockpile. The consequences of accidents vary considerably and the risk, while ranging from low to extremely low, is still finite. Impacts to the physical, biological, and human environment will also result in the event of an accident. Land use and loss of habitat for wildlife will occur as the result of any of the disposal alternatives. The amount of loss varies from approximately 11 acres to 36 acres per site for the regional centers to 55 acres for the national disposal center. The transportation alternatives would cause the loss of additional lands at both source and destination installations for constructing or modifying rail spurs. LEGAL MANDATES: Clean Air Act of 1977, as amended (42 U.S.C 7411 et seq.), Department of Defense Authorization Act (P.L. 99-145), Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.), Hazardous Materials Transportation Act (49 U.S.C. 1801 et seq.), and Resource Conservation and Recovery Act of 1976 (42 U.S.C. 6901 et seq.).
JF  - EPA number: 860263, 524 pages, July 1, 1986
PY  - 1986
KW  - Wastes
KW  - Air Quality
KW  - Chemical Agents
KW  - Disposal
KW  - Emissions
KW  - Endangered Species (Animals)
KW  - Health Hazards
KW  - Land Use
KW  - Military Facilities (Army)
KW  - Mines
KW  - Missiles
KW  - Munitions
KW  - Particulates
KW  - Safety
KW  - Storage
KW  - Transportation
KW  - Water Quality
KW  - Wildlife Habitat
KW  - United States
KW  - Clean Air Act of 1977, as amended, Emission Standards
KW  - Department of Defense Authorization Act, Project Authorization
KW  - Federal Water Pollution Control Act of 1972, Compliance
KW  - Hazardous Materials Transportation Act, Compliance
KW  - Resource Conservation and Recovery Act of 1976, Compliance
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Name - Department of the Army, Program Manager for Chemical Demilitarization, Aberdeen Proving Ground, Maryland; ARMY
N1  - Date revised - 2006-05-01
N1  - SuppNotes - Draft. Preparation date: July 1, 1986
N1  - Last updated - 2011-12-16
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519945143
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944164
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Server Intervention: "Will It Work?"
AN  - 1474330191
AB  - A report of ongoing research into the effects of a pilot server intervention program.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 12
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - NHTSA Responsible Beverage Service Research and Evaluation Project
AN  - 1474330014
AB  - A research project to develop and refine server training programs for commercial and social hosts.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 20
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Safety Update
AN  - 1474329969
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 68
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - College Alcohol Survey: "1985, 1982, and 1979"
AN  - 1474329614
AB  - Results of three surveys of alcohol problems and policies on college campuses are compared.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 46
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Point-of-Purchase Health Warning Notices
AN  - 1474329441
AB  - Some communities have begun to require that retail alcohol vendors post notices warning of the connection between drinking during pregnancy and the occurrence of birth defects.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 36
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Occupational Arena
AN  - 1474327635
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 69
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 12: "State, Regional, and National Trends in Apparent Per Capita Consumption"
AN  - 1474327630
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 60
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474327630?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Epidemiologic+Bulletin+No.+12%3A+%22State%2C+Regional%2C+and+National+Trends+in+Apparent+Per+Capita+Consumption%22&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-07-01&rft.volume=10&rft.issue=4&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - "Because We Care..." - "The 1985 National Drunk and Drugged Driving Awareness Campaign"
AN  - 1474325382
AB  - Materials and activities involved in a public education campaign are described.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - News Notes
AN  - 1474324559
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 67
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Issues and Implications in Genetics Research
AN  - 1474323706
AB  - A review of the research favoring a genetics-based explanation for alcoholism.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 54
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - NIAAA Intramural Studies in Metabolism: "Explorers Along the Metabolic Pathway"
AN  - 1474323605
AB  - Investigators search metabolic pathways for evidence linking genes and alcoholism.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 50
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Social Host Liability: "Kelly versus Gwinnell"
AN  - 1474303539
AB  - A report on the New Jersey Supreme Court decision concerning the liability of social hosts for damages caused by their drunken guests.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 32
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Arena Managers Project: "A TEAM Approach"
AN  - 1474302705
AB  - A collaborative project to develop and fieldtest responsible beverage service policies and practices for large arenas.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 30
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Perspectives
AN  - 1474302383
AB  - Representatives of the legal profession, the alcohol field, consumer groups, and the hospitality industry comment on server responsibility issues.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 38
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474302383?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Beyond Server Training: "An Examination of Future Issues"
AN  - 1474302033
AB  - A proposal for new administrative mechanisms to ensure responsible beverage service policies and practices.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 24
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474301571
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 64
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Prevention Research: "The Model Dram Shop Act of 1985"
AN  - 1474301192
AB  - A description of the current status of dram shop liability in the United States and a review of a model dram shop law.
JF  - Alcohol Health and Research World
Y1  - 1986///Summer
PY  - 1986
DA  - Summer 1986
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A Comparison of Two Methods for Quantifying D-Glucaric Acid
AN  - 1093459700; 17184889
AB  - The relative usefulness of two spectrophotometric methods for quantifying urinary D-glucaric acid was evaluated. The enzyme inhibition method measures the inhibition of I?-D-glucuronidase by the 1,4-glucarolactone produced from D-glucaric acid in urine by boiling at acidic pH. The glyoxylic acid method measures glyoxylic acid produced from the oxidation of D-glucaric acid which has first been separated from other urinary compounds by ion exchange chromatography. For a group of 61 healthy adults, the enzyme inhibition method gave a range similar to that of previously reported values: 0 to 6.44 mmol D-glucaric acid/mol creatinine (99% confidence limits). Similar values were obtained from standard solutions by the two methods. Recovery was approximately 105% by both methods. Urinary concentrations, however, were often from 3 to 10 times higher by the glyoxylic acid method. The higher values were probably due to interference from ascorbic acid and other glyoxylic acid-producing compounds, because the reduction of interfering compounds with sodium borohydride before chromatography resulted in concentrations of less than half of those originally observed. It is concluded that the modification of the enzyme inhibition method is preferable because it is less subject to interference and less labor intensive than the glyoxylic acid method.
JF  - Journal of Analytical Toxicology
AU  - Steinberg, K K
AU  - Needham, L L
AD  - Division of Environmental Health, Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333
Y1  - 1986/07//
PY  - 1986
DA  - July 1986
SP  - 139
EP  - 141
PB  - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States
VL  - 10
IS  - 4
SN  - 0146-4760, 0146-4760
KW  - Toxicology Abstracts
KW  - Chromatography
KW  - Enzymes
KW  - Ascorbic acid
KW  - Sodium
KW  - Creatinine
KW  - Urine
KW  - Boiling
KW  - Oxidation
KW  - Glyoxylic acid
KW  - Spectrophotometry
KW  - Ion exchange
KW  - pH effects
KW  - X 24300:Methods
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L2  - http://www.ingentaconnect.com/content/oup/jat/1986/00000010/00000004/art00004
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2012-10-01
N1  - Last updated - 2016-02-29
N1  - SubjectsTermNotLitGenreText - Sodium; Creatinine; Boiling; Urine; Chromatography; Oxidation; Enzymes; Glyoxylic acid; Spectrophotometry; pH effects; Ion exchange; Ascorbic acid
ER  - 



TY  - JOUR
T1  - Alcohol and Disinhibition: Nature and Meaning of the Link
AN  - 60956869; 87a47398
JF  - Sociology of Health and Illness
AU  - Burr, Angela
AU  - Burr, Angela
Y1  - 1986/06//
PY  - 1986
DA  - June 1986
SP  - 205
VL  - 8
IS  - 2
SN  - 0141-9889, 0141-9889
KW  - article
KW  - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.)
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LA  - English
DB  - Sociological Abstracts
N1  - Date revised - 2007-04-01
N1  - SuppNotes - Edition date: 1983.
N1  - Last updated - 2016-09-28
N1  - CODEN - SHILDJ
ER  - 



TY  - JOUR
T1  - Interpreting risks to the public.
AN  - 77359072; 3453170
AB  - Human beings have always lived with risks and have coped as best they could, according to their perceptions of the relative dangers and the mechanisms available to them. Being conscious of risks helps us to confront and cope with them, but it also has negative effects. The multiplicity of threats and the urgency with which they are presented make it difficult to sort out those that we as individuals can control from those that we cannot. Consequently, we are in danger of surrendering to feelings of helplessness and apathy, which paralyze us in the act of coping even in situations in which personal action can make a difference. The challenge for those of us engaged in interpreting risks to the public is to do so in such a way that we convey a sense of relative risk; and, cumulatively over time, we need to "accentuate the positive" in the sense of communicating that it is well worth the effort for people to control those risks they can control. Risks over which individuals fell they have no control contrast with those related to daily lifestyle decisions. The public is aware of the risks associated with these decisions, but because of some overriding fears, the daily lifestyle choices receive lower priority than they deserve from the public. As health professionals, we can improve ways of presenting the most serious and most controllable threats and reach broader audiences with key messages.
JF  - American journal of preventive medicine
AU  - Mason, J O
AU  - Ogden, H G
AU  - Berreth, D A
AU  - Martin, L Y
AD  - Department of Health and Human Services, Centers for Disease Control, Atlanta, GA 30333.
PY  - 1986
SP  - 133
EP  - 139
VL  - 2
IS  - 3
SN  - 0749-3797, 0749-3797
KW  - Environmental Pollutants
KW  - 0
KW  - Index Medicus
KW  - Environmental Health
KW  - Environmental Exposure
KW  - Preventive Medicine
KW  - Risk
KW  - Health Education
KW  - Environmental Pollutants -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-08-24
N1  - Date created - 1988-08-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Relationships between the DNA adducts and the mutations and sister-chromatid exchanges produced in Chinese hamster ovary cells by N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene.
AN  - 77347840; 3331660
AB  - Chinese hamster ovary cells were exposed to N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene, and the resulting DNA adducts, sister-chromatid exchanges (SCEs) and mutations at the hypoxanthine-guanine phosphoribosyl transferase locus were quantified. Each agent produced a major DNA adduct substituted through the C8 of deoxyguanosine. When the data from all three agents were combined, both mutation and SCE induction correlated strongly with the concentration of DNA adducts. However, significant differences were found in the relationships between adduct formation and the biological responses produced by the individual agents. While N-hydroxy-N'-acetylbenzidine induced the most mutations per adduct, N-hydroxy-2-aminofluorene caused the greatest number of SCEs per adduct. The data support the involvement of C8-deoxyguanosine adducts in mutation and SCE induction, and indicate that the structure of the group adducted to DNA may be an important factor in determining the magnitude of these biological responses. These findings also suggest that SCE and mutation induction are independent expressions of DNA damage.
JF  - Mutagenesis
AU  - Heflich, R H
AU  - Morris, S M
AU  - Beranek, D T
AU  - McGarrity, L J
AU  - Chen, J J
AU  - Beland, F A
AD  - National Center for Toxicological Research, Jefferson, AR 72079.
Y1  - 1986/05//
PY  - 1986
DA  - May 1986
SP  - 201
EP  - 206
VL  - 1
IS  - 3
SN  - 0267-8357, 0267-8357
KW  - Alkylating Agents
KW  - 0
KW  - Benzidines
KW  - Fluorenes
KW  - Pyrenes
KW  - N-hydroxy-2-aminofluorene
KW  - 61M94X4V24
KW  - N-hydroxy-N'-acetylbenzidine
KW  - 71609-23-9
KW  - 1-nitrosopyrene
KW  - 86674-51-3
KW  - Index Medicus
KW  - Animals
KW  - Cricetulus
KW  - Dose-Response Relationship, Drug
KW  - Cell Line
KW  - Cricetinae
KW  - Pyrenes -- pharmacology
KW  - Fluorenes -- pharmacology
KW  - DNA Damage
KW  - Alkylating Agents -- pharmacology
KW  - Sister Chromatid Exchange -- drug effects
KW  - Mutation
KW  - Benzidines -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-10-11
N1  - Date created - 1988-10-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - GEN
T1  - Surgeon General's Workshop on Violence and Public Health Report (Leesburg, Virginia, October 27-29, 1985).
AN  - 63158909; ED285118
AB  - Plenary session papers from a workshop focusing on how the health professions might provide better care for victims of violence and prevent violence itself comprise this document. Papers include: (1) "Welcome and 'Charge' to the Participants" (C. Everett Koop); (2) "Interpersonal Violence and Public Health Care: New Directions, New Challenges" (Marvin E. Wolfgang); (3) "Violence and Public Health" (William H. Foege); (4) "Interpersonal Violence: A Comprehensive Model in a Hospital Setting--from Policy to Program" (Karil S. Klingbeil); (5) "Interdisciplinary Interventions Applicable to Prevention of Interpersonal Violence and Homicide in Black Youth" (Deborah Prothrow-Stith); and (6) "This Epidemic of Family Violence" (Anthony V. Bouza). Recommendations from the workshop's work groups on the topics of assault and homicide, child abuse, child sexual abuse, elder abuse, rape and sexual assault, and spouse abuse are included. Results of a Delphi survey on the roles of education and research in violence and medical, health, and social services delivery are presented. (ABL)
Y1  - 1986/05//
PY  - 1986
DA  - May 1986
SP  - 103
KW  - Homicide
KW  - ERIC, Resources in Education (RIE)
KW  - Rape
KW  - Crime
KW  - Delivery Systems
KW  - Violence
KW  - Health Services
KW  - Elder Abuse
KW  - Prevention
KW  - Public Health
KW  - Victims of Crime
KW  - Health Personnel
KW  - Family Violence
KW  - Sexual Abuse
KW  - Child Abuse
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63158909?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - 1H NMR study of self-association and restricted internal rotation of the C8-substituted deoxyguanosine 5'-monophosphate adduct of the carcinogen 2-(acetylamino)fluorene.
AN  - 77423015; 3271419
AB  - The high-field 1H NMR spectra of a nucleotide-carcinogen adduct formed from 2-(acetylamino)fluorene (8-(N-fluoren-2-ylacetamido)-2'-deoxyguanosine 5'-monophosphate) have been examined in aqueous solution as a function of concentration at high and low temperatures. An anomalous concentration dependence of NMR spectra was observed at concentration levels over 1 mM. These spectral characteristics have been analyzed in terms of changes in self-association and in the interconversions between torsional diastereomers associated with the central nitrogen. Association constants have been computed. Stacking interactions, which involve both the fluorene and guanine rings, are strong, cooperative and highly temperature-dependent. Deacetylation alters the mode of stacking. Several effects of solvent and aggregation on the conformation at the central nitrogen are discussed.
JF  - Journal of biomolecular structure & dynamics
AU  - Evans, F E
AU  - Miller, D W
AU  - Levine, R A
AD  - Division of Chemistry, Food and Drug Administration, Jefferson, Arkansas 72079.
Y1  - 1986/04//
PY  - 1986
DA  - April 1986
SP  - 935
EP  - 948
VL  - 3
IS  - 5
SN  - 0739-1102, 0739-1102
KW  - Deoxyguanine Nucleotides
KW  - 0
KW  - 8-(N-fluoren-2-ylacetamido)-2'-deoxyguanosine 5'-monophosphate
KW  - 14490-86-9
KW  - 2'-deoxyguanosine 5'-phosphate
KW  - 7EAM4TG712
KW  - 2-Acetylaminofluorene
KW  - 9M98QLJ2DL
KW  - Index Medicus
KW  - Temperature
KW  - Molecular Conformation
KW  - Magnetic Resonance Spectroscopy
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77423015?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+structure+%26+dynamics&rft.atitle=1H+NMR+study+of+self-association+and+restricted+internal+rotation+of+the+C8-substituted+deoxyguanosine+5%27-monophosphate+adduct+of+the+carcinogen+2-%28acetylamino%29fluorene.&rft.au=Evans%2C+F+E%3BMiller%2C+D+W%3BLevine%2C+R+A&rft.aulast=Evans&rft.aufirst=F&rft.date=1986-04-01&rft.volume=3&rft.issue=5&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+structure+%26+dynamics&rft.issn=07391102&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1990-03-20
N1  - Date created - 1990-03-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Conformation and configuration at the central amine nitrogen of a nucleotide adduct of the carcinogen 2-(acetylamino)fluorene as studied by 13C and 15N NMR spectroscopy.
AN  - 77411102; 3271418
AB  - The conformation and configuration at the central nitrogen of the adduct 8-(N-fluoren-2-ylamino)-2'-deoxyguanosine 5'-monophosphate has been investigated by high-field 13C and 15N NMR spectroscopy. One-bond nitrogen-hydrogen coupling constants and 13C chemical shifts for the adduct as well as for the model compounds diphenylamine, 4-nitrodiphenylamine and 2-aminofluorene have been measured in nonaqueous solutions. The data indicate a near planar configuration at the amine nitrogen that links the guanine and fluorene rings of the adduct. The orientations about the guanyl-nitrogen and fluorenyl-nitrogen bonds place the two ring systems in either perpendicular (Type A) or helical (Type B) conformations. It is suggested, based on structural similarities to diarylamines, that the G-N-C bond angle of the adduct is greater than 120 degrees in order to reduce unfavorable steric interactions between the two ring systems. Space-filling molecular models of the adduct in duplex DNA show that the aminofluorene moiety can be oriented into both Type A and Type B conformations within the major groove. The configuration at nitrogen of diphenylamine, 4-nitrodiphenylamine and 2-aminofluorene has also been examined.
JF  - Journal of biomolecular structure & dynamics
AU  - Evans, F E
AU  - Levine, R A
AD  - Division of Chemistry, Food and Drug Administration, Jefferson, AR 72079.
Y1  - 1986/04//
PY  - 1986
DA  - April 1986
SP  - 923
EP  - 934
VL  - 3
IS  - 5
SN  - 0739-1102, 0739-1102
KW  - Deoxyguanine Nucleotides
KW  - 0
KW  - 8-(N-fluoren-2-ylamino)-2'-deoxyguanosine 5'-monophosphate
KW  - 17660-46-7
KW  - 2'-deoxyguanosine 5'-phosphate
KW  - 7EAM4TG712
KW  - DNA
KW  - 9007-49-2
KW  - 2-Acetylaminofluorene
KW  - 9M98QLJ2DL
KW  - Nitrogen
KW  - N762921K75
KW  - Index Medicus
KW  - Molecular Conformation
KW  - Magnetic Resonance Spectroscopy
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1990-03-20
N1  - Date created - 1990-03-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - RPRT
T1  - The Health Consequences of Using Smokeless Tobacco: A Report of the Advisory Committee to the Surgeon General.
AN  - 63232264; ED282135
AB  - This report on the health consequences of smokeless tobacco contains an "Introduction, Overview, and Conclusions" section and four major chapters. Chapter 1 defines the various forms of smokeless tobacco that are used in the United States and examines data pertaining to trends in prevalence and patterns of use. Methodological considerations are discussed and research needs are identified. Chapter 2 presents results of a systematic review of the world's medical literature describing experimental and human evidence pertinent to the evaluation of smokeless tobacco as a potential cause of cancer. Consensus summaries of the literature are presented in each of five categories: (1) epidemiological studies and case reports of oral cancer in relation to smokeless tobacco use; (2) epidemiological studies of other cancers in relation to smokeless tobacco; (3) chemical constituents, including carcinogens of smokeless tobacco; (4) metabolism of constituents of smokeless tobacco; and (5) experimental studies involving exposing laboratory animals to smokeless tobacco or its constituents. Chapter 3 addresses the health effects of smokeless tobacco use on the oral tissues through a systematic review of the relevant scientific literature of animal and human studies. Chapter 4 examines the consequences of exposure to nicotine from smokeless tobacco. The report concludes that the oral use of smokeless tobacco represents a significant health risk, can cause cancer and a number of noncancerous oral conditions, and can lead to nicotine addiction and dependence. (NB)
Y1  - 1986/04//
PY  - 1986
DA  - April 1986
SP  - 213
PB  - Superintendent of Documents, U.S. Government Printing Office, Washington, DC 20402.
VL  - NIH-86-2874
KW  - Smokeless Tobacco
KW  - ERIC, Resources in Education (RIE)
KW  - Public Health
KW  - Epidemiology
KW  - Health Conditions
KW  - Tobacco
KW  - Health
KW  - Diseases
KW  - Trend Analysis
KW  - Cancer
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63232264?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - The "Small Beginnings" of Euthanasia: Examining the Erosion in Legal Prohibitions against Mercy-Killing
AN  - 1761723257; 198701179
AB  - An examination of recent legislation & court decisions addressing the issue of mercy killing, ie, euthanasia. Disscussed are: (1) the legislative definition of death; (2) legislation regarding the living will; & (3) recent judicial opinions regarding euthanasia. Changes in the obligation to provide medical treatment to seriously ill & incompetent patients are seen to have created a legal climate favorable to euthanasia, by either omission or direct action. Consequences of such a climate are discussed, & the complexity of the task of restricting euthanasia is described. F. Rasmussen
JF  - Notre Dame Journal of Law, Ethics & Public Policy
AU  - Koop, C Everett
AU  - Grant, Edward R
AD  - US Public Health Service, 5600 Fishers Ln Rockville MD 20852
Y1  - 1986/04//
PY  - 1986
DA  - April 1986
SP  - 585
EP  - 634
VL  - 2
IS  - 3
SN  - 0883-3648, 0883-3648
KW  - euthanasia, legislation/court decisions, US
KW  - United States of America
KW  - Judicial Decisions
KW  - Euthanasia
KW  - Legislation
KW  - article
KW  - 7210: social policy
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Notre+Dame+Journal+of+Law%2C+Ethics+%26+Public+Policy&rft.atitle=The+%22Small+Beginnings%22+of+Euthanasia%3A+Examining+the+Erosion+in+Legal+Prohibitions+against+Mercy-Killing&rft.au=Koop%2C+C+Everett%3BGrant%2C+Edward+R&rft.aulast=Koop&rft.aufirst=C&rft.date=1986-04-01&rft.volume=2&rft.issue=3&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Notre+Dame+Journal+of+Law%2C+Ethics+%26+Public+Policy&rft.issn=08833648&rft_id=info:doi/
LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2016-02-01
N1  - Last updated - 2016-09-28
N1  - SubjectsTermNotLitGenreText - Euthanasia; United States of America; Judicial Decisions; Legislation
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944917
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 1
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Middle+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-04-01&rft.volume=10&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944340
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 35
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944340?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Back+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-04-01&rft.volume=10&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944267
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519944267?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-04-01&rft.volume=10&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - RPRT
T1  - Health hazard evaluation report HETA 86-045-1681, 101 Marietta Tower Building, Atlanta, Georgia.
AN  - 14746433; 1613878
AB  - A reevaluation of the air quality in the Marietta Tower Building (SIC-9190), Atlanta, Georgia was requested by the DHHS Region IV Employee Health and Safety Committee because of worker complaints about sinus problems, eye irritation and headaches. Air cooling and circulation units were inspected on six floors. Outside air supply to these floors was measured and the buildup of carbon-dioxide (124389) (C02) determined as an indicator of indoor pollution.
JF  - NTIS, SPRINGFIELD, VA (USA). 1986.
AU  - Salisbury, S
AU  - Roper, P
Y1  - 1986/04//
PY  - 1986
DA  - Apr 1986
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - Georgia, Atlanta
KW  - Pollution Abstracts
KW  - air quality
KW  - buildings
KW  - public health
KW  - carbon dioxide
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - NTIS Order No.: PB87-163366/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Alcohol and Cancer of the Head and Neck
AN  - 1474330122
AB  - Alcoholics experience an excess risk of developing cancer of the head and neck.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 34
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474330122?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Cancer+of+the+Head+and+Neck&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-04-01&rft.volume=10&rft.issue=3&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Overview: Alcohol and Cancer
AN  - 1474329253
AB  - A review of the state of the knowledge on alcohol as a risk factor for cancer.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Psychosocial Rehabilitation of Alcoholic Patients with Head and Neck Cancer
AN  - 1474325975
AB  - A discussion of group support, education, and reinforcement techniques used in the rehabilitation of alcoholic patients with head and neck cancer.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 38
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Interaction of Ethanol with Vitamin A in Liver and in Tumor Development
AN  - 1474325355
AB  - Evidence for a role of alcohol-related vitamin A deficiency in the development of tumors.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Interaction+of+Ethanol+with+Vitamin+A+in+Liver+and+in+Tumor+Development&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-04-01&rft.volume=10&rft.issue=3&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Tobacco Consumption as Risk Factors for Cancer
AN  - 1474324575
AB  - Studies strongly suggest that alcohol and tobacco use have a synergistic effect in elevating one's risk of developing cancers of the head and neck.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474324575?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Tobacco+Consumption+as+Risk+Factors+for+Cancer&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-04-01&rft.volume=10&rft.issue=3&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol Consumption and the Risk of Breast Cancer
AN  - 1474303422
AB  - Many potential causes of breast cancer have been investigated but attention has only recently been paid to the consumption of alcoholic beverages as a risk factor for breast cancer.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 40
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Cancer Prevention Awareness
AN  - 1474302176
AB  - The Cancer Prevention Awareness Program presents alcohol and cancer messages.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 44
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Mechanisms for the Interrelationship Between Alcohol and Cancer
AN  - 1474301790
AB  - A discussion of the underlying mechanisms by which alcohol is believed to play a role in carcinogenesis.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 10
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Ethanol and the Repair of Deoxyribonucleic Acid (DNA)
AN  - 1474301399
AB  - One of the mechanisms by which alcohol abuse may increase one's risk of developing cancer is by inhibiting the cell's ability to repair carcinogen-induced damage to DNA, the molecule within the cell that contains genetic information.
JF  - Alcohol Health and Research World
Y1  - 1986///Spring
PY  - 1986
DA  - Spring 1986
SP  - 26
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - RPRT
T1  - Morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite.
AN  - 14493704; 1410257
AB  - A morbidity and mortality study on vermiculite workers was conducted. In the mortality study, the cohort consisted of 581 workers, 569 males, who were hired at a vermiculite mill and mine in Montana before 1970 and worked for longer than 1 year. Vital status of the cohort as of December 31, 1981 was determined. Death certificates were obtained and reviewed. Exposures were estimated from previously obtained air sampling data. In the morbidity study, the cohort consisted of 191 males employed for at least 5 years from 1975 to 1982. Chest X-rays were examined. A questionnaire on occupational and smoking history and respiratory symptoms was administered. In the mortality study, the average cumulative exposure for the entire cohort was 196.3 fiber years (fy), range less than 30 to over 2,000fy. Excessive lung cancer and non respiratory disease mortality occurred. This was associated with cumulative exposure. In the morbidity study, cumulative exposure was associated with parenchymal and pleural X-ray abnormalities and increased dyspnea. The author concludes that cumulative fiber exposures above 400fy are associated with increased risks of lung cancer mortality. Smoking must be considered as a possible confounding factor as the data was not controlled for the effects of smoking.
JF  - NTIS, SPRINGFIELD, VA (USA). 1986.
AU  - Amandus, H
Y1  - 1986/04//
PY  - 1986
DA  - Apr 1986
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - vermiculite
KW  - Montana
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - mining
KW  - occupational health
KW  - mortality
KW  - air sampling
KW  - morbidity
KW  - H SI2.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-224250/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Administration of the Radiation Control for Health and Safety Act of 1968, Public Law 90-602, April 1, 1986 (1985 annual report).
AN  - 14429649; 1343358
AB  - The Food and Drug Administration, through its Center for Devices and Radiological Health, is responsible for the day-to-day administration of the Radiation Control for Health and Safety Act of 1968. The report provides a summary of the operations of the Center in carrying out that responsibility for calendar year 1985.
JF  - NTIS, SPRINGFIELD, VA (USA). 1986.
Y1  - 1986/04//
PY  - 1986
DA  - Apr 1986
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - FDA
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - radiology
KW  - legislation
KW  - H SM7.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
KW  - P 8000:RADIATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-185683/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Biodegradation of tert-Butylphenyl Diphenyl Phosphate
AN  - 19004608; 8700360
AB  - Biodegradation of tert-butylphenyl diphenyl phosphate (BPDP) was examined in microcosms containing sediment and water from five different ecosystems to elucidate the environmental fate of phosphate ester flame retardants. Biodegradation of (14C)BPDP was monitored in the environmental microcosms by measuring the evolution of (14C). Over 37% of BPDP was mineralized after 8 weeks in microcosms from an ecosystem which had chronic exposure to agricultural chemicals. In contrast, only 1.7% of BPDP was degraded in samples from a noncontaminated site. The exposure concentration of BPDP affected the percentage which was degraded in microcosms from the two most active ecosystems. Mineralization was highest at a concentration of 0.1 mg of BPDP and was inhibited with 10- and 100-fold higher concentrations of BPDP in these microcosms. Indigenous heterotrophic and BPDP-utilizing microbial populations and phosphoesterase enzyme activities were highest in sedients which had the highest biodegradation of BPDP. Adaptive increases in both microbial populations and phosphoesterase enzymes in some sediments acclimated to BPDP were observed. These data suggest that the microbial degradation of BPDP results from at least three catabolic processes and is highest when low concentrations of BPDP are exposed sediment microorganisms of eutrophic ecosystems which have high phosphotri- and diesterase activities and previous exposure to anthropogenic chemicals. (Author 's abstract)
JF  - Applied and Environmental Microbiology AEMIDF Vol. 51, No. 2, p 316-322, February 1986. 3 fig, 4 tab, 25 ref.
AU  - Heitkamp, MA
AU  - Freeman, J P
AU  - Cerniglia, CE
AD  - National Center for Toxicological Research Jefferson, AR
Y1  - 1986/02//
PY  - 1986
DA  - Feb 1986
KW  - Water Resources Abstracts
KW  - Biodegradation
KW  - Microbial degradation
KW  - Organic compounds
KW  - Path of pollutants
KW  - Sediments
KW  - Aquatic plants
KW  - Agriculture runoff
KW  - Organophosphorous compounds
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Metabolism, disposition, and toxicity of drugs and other xenobiotics in aquatic species.
AN  - 77404479; 3334693
AB  - An overview is given of the absorption, distribution, excretion, and in vivo metabolism of drugs in fish. Several methods for chemical disposition and metabolism in fish are outlined, and a few well-characterized studies of the relationships between xenobiotic metabolism and toxicity in aquatic species are highlighted. For more than 40 drugs and other xenobiotics in several species of fish, concentrations of chemicals in bile were usually considerably higher than values in other body compartments or in the surrounding water. This was shown to be true particularly for parent substances or their biotransformed products with molecular weights greater than 400. The use of bile analysis is recommended as a regulatory tool to detect contamination of fish from drug treatment or environmental exposure.
JF  - Veterinary and human toxicology
AU  - Guarino, A M
AU  - Lech, J J
AD  - Food and Drug Administration, Fishery Research Branch, Dauphin Island, Alabama 36528.
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 38
EP  - 44
VL  - 28 Suppl 1
SN  - 0145-6296, 0145-6296
KW  - Pharmaceutical Preparations
KW  - 0
KW  - Xenobiotics
KW  - Index Medicus
KW  - Animals
KW  - Bile -- metabolism
KW  - Toxicology
KW  - Pharmaceutical Preparations -- metabolism
KW  - Xenobiotics -- metabolism
KW  - Fishes -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1989-10-06
N1  - Date created - 1989-10-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Toxicological Studies With 6-Mercaptopurine in Neonates
AN  - 760216038; 13623425
AB  - Abstract not available.
JF  - Toxicology and Industrial Health
AU  - Alleva, Frederic R
AU  - Slaughter, Lynnard J
AU  - Abraham, AAndrew
AU  - Balazs, Tibor
AD  - Center for Drugs and Biologics Division of Drug Biology Food and Drug Administration Washington, D.C
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 11
EP  - 23
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 2
IS  - 2
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - 6-Mercaptopurine
KW  - neonates
KW  - toxicological studies.
KW  - Neonates
KW  - Toxicity testing
KW  - X 24350:Industrial Chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 6
N1  - Last updated - 2015-03-19
N1  - SubjectsTermNotLitGenreText - Neonates; 6-Mercaptopurine; Toxicity testing
DO  - http://dx.doi.org/10.1177/074823378600200202
ER  - 



TY  - JOUR
T1  - Macromolecular Levels, Dna Synthesis and Ornithine Decarboxylase Activity in Leg Muscles From 6-Mercaptopurine-Treated Rats
AN  - 760215911; 13623430
AB  - Abstract not available.
JF  - Toxicology and Industrial Health
AU  - Friedman, Leonard
AU  - Gaines, Dennis W
AU  - Alleva, Frederic R
AU  - Seidler, Frederic J
AU  - Flynn, Thomas J
AU  - Slotkin, Theodore A
AU  - Balazs, Tibor
AD  - Division of Toxicology, The Center for Food Safety and Applied Nutrition Food and Drug Administration Washington, D.C
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 57
EP  - 68
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 2
IS  - 2
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - DNA synthesis
KW  - leg muscles
KW  - macromolecular levels
KW  - 6-Mercaptopurine
KW  - ornithine decarboxylase activity.
KW  - Leg
KW  - DNA biosynthesis
KW  - Macromolecules
KW  - Muscles
KW  - Ornithine decarboxylase
KW  - X 24350:Industrial Chemicals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760215911?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Macromolecular+Levels%2C+Dna+Synthesis+and+Ornithine+Decarboxylase+Activity+in+Leg+Muscles+From+6-Mercaptopurine-Treated+Rats&rft.au=Friedman%2C+Leonard%3BGaines%2C+Dennis+W%3BAlleva%2C+Frederic+R%3BSeidler%2C+Frederic+J%3BFlynn%2C+Thomas+J%3BSlotkin%2C+Theodore+A%3BBalazs%2C+Tibor&rft.aulast=Friedman&rft.aufirst=Leonard&rft.date=1986-01-01&rft.volume=2&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378600200207
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 32
N1  - Last updated - 2015-03-19
N1  - SubjectsTermNotLitGenreText - Leg; DNA biosynthesis; Macromolecules; Ornithine decarboxylase; Muscles
DO  - http://dx.doi.org/10.1177/074823378600200207
ER  - 



TY  - GEN
T1  - Family Food Choices: A Guide to Weight and Diabetes Control.
AN  - 63230121; ED281706
AB  - Written for American Indians who have diabetes, this folder explains diabetes and outlines a weight control program and diet. The folder discusses the five things diabetics can do to help control their disease: lose weight, watch the amount and kind of fat eaten, eat more food with fiber, avoid sugar, and avoid alcohol. Charts for foods containing fats--meat, fowl, fish, eggs, dairy, oils and fats--list common foods by low, medium, high, and very high fat content and suggest how frequently these foods should be used. Charts for foods containing fiber--vegetables, fruits, starches--list common foods by high, medium, and low fiber content and suggest ways to eat more fiber. A discussion of sugar suggests foods to avoid and ways to eat less sugar. Tips on how to drink less alcohol suggest drinks which can be substituted. (LFL)
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 15
KW  - ERIC, Resources in Education (RIE)
KW  - Community
KW  - Obesity
KW  - Eating Habits
KW  - Nutrition Instruction
KW  - Food
KW  - Dietetics
KW  - Alcohol Education
KW  - Patient Education
KW  - American Indians
KW  - Diabetes
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63230121?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - This report was done with the cooperation of the M
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Surgeon General's Report on Acquired Immune Deficiency Syndrome.
AN  - 63224508; ED277672
AB  - This report on Acquired Immune Deficiency Syndrome (AIDS) offers information on: (1) the medical definition of AIDS; (2) signs and symptoms; (3) the present situtation regarding the number of cases of AIDS and how the disease is transmitted; (4) how to protect oneself from AIDS; (5) what behavior is safe; and (6) what is currently understood about AIDS. Further sources of information are listed. (JD)
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 35
KW  - ERIC, Resources in Education (RIE)
KW  - Sexuality
KW  - Life Style
KW  - Public Health
KW  - Acquired Immunodeficiency Syndrome
KW  - Preventive Medicine
KW  - Disease Incidence
KW  - Drug Abuse
KW  - Disease Control
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63224508?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - GEN
T1  - Nutrition & Adolescent Pregnancy: A Selected Annotated Bibliography.
AN  - 63144688; ED294112
AB  - This annotated bibliography on nutrition and adolescent pregnancy is intended to be a source of technical assistance for nurses, nutritionists, physicians, educators, social workers, and other personnel concerned with improving the health of teenage mothers and their babies. It is divided into two major sections. The first section lists selected articles and books to help providers develop or update their own knowledge base and skills. Subdivided into 15 topical areas, it includes physiological, psychosocial, and nutritional aspects of adolescent pregnancy, as well as assessment and counseling techniques and model service programs. Citations are primarily limited to peer-review journals and books published in North America, the majority of which were published between 1980 and 1985. Some earlier references are included for better understanding of recent literature or for their historical significance. The second section provides abstracts of educational materials that can be used by providers in educating and counseling pregnant adolescents. Cost and ordering information is provided for each entry. The materials are arranged in four categories: Teaching Tools for Nutritional Counseling, Self-Instructional Handouts, Posters and Films, and Curricula and Resource Manuals. Questionnaires and an evaluation tool are appended. (NB)
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 108
PB  - National MCH Clearinghouse, 38th and R Streets, N.W., Washington, DC 20057.
KW  - ERIC, Resources in Education (RIE)
KW  - Practitioners
KW  - Parent Education
KW  - Instructional Materials
KW  - Early Parenthood
KW  - Counseling Techniques
KW  - Females
KW  - Annotated Bibliographies
KW  - Prenatal Influences
KW  - Nutrition
KW  - Adolescents
KW  - Pregnancy
KW  - Infants
KW  - Parent Education
KW  - Instructional Materials
KW  - Early Parenthood
KW  - Counseling Techniques
KW  - Females
KW  - Annotated Bibliographies
KW  - Prenatal Influences
KW  - Nutrition
KW  - Adolescents
KW  - Pregnancy
KW  - Infants
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63144688?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - BOOK
T1  - Health status of the disadvantaged: chartbook, 1986
T2  - Dept. of Health and Human Services. DHHS pubn. no. (HRSA) HRS-P-DV86-2
AN  - 59416330; 1987-1502021
AB  - Demography and health status, utilization of health services, enrollments in the health professions, and expenditures for health care, by ethnic group, age, sex, and other socioeconomic characteristics.
JF  - Supt Docs, 1986. xii+127 pp.
Y1  - 1986///0,
PY  - 1986
DA  - 0, 1986
EP  - xii+127
PB  - Supt Docs
KW  - Socially handicapped -- Medical care -- Statistics
KW  - Medical profession -- Statistics
KW  - United States -- Ethnic groups -- Health
KW  - Medical service -- Statistics
KW  - Poor -- Health -- Statistics
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2006-09-28
N1  - Availability - Supt Docs (28 x 21 cm.) pa $9
N1  - Document feature - table(s), chart(s), map(s)
N1  - Last updated - 2016-09-28
ER  - 



TY  - BOOK
T1  - Private health insurance in the United States
AN  - 36853505; 815967
JF  - Private health insurance in the United States
AU  - Farley, Pamela J
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 106
PB  - US Dept. of Health and Human Services, Public Health Service, National Center for Health Services Research and Health Care Technology Assessment
KW  - Economics
KW  - Health insurance
KW  - U.S.A.
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LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - SuppNotes - ill., bibl.; Springfield, VA : Available from National Technical Information Service
N1  - Last updated - 2013-09-16
ER  - 



TY  - JOUR
T1  - Surrogate-Assisted Determination of 2,3,7 ,8-Tetrachlorodibenzo-p-Dioxin in Fish by Electron Capture Capillary Gas Chromatography
AN  - 19016320; 8704691
AB  - Surrogate spiking the sample with 1000 parts per trillion (ppt) 1,3,7,8-tetrachlorodibenzo-p-dioxin (1378-TCDD) has doubled analytical throughput in determining toxic 2378-TCDD (analyte) at the low part-per-trillion level in fish, using multicolumn high resolution liquid chromatographic cleanup before quantitation by capillary gas chromatography with electron capture detection. The 1378- and 2378-TCDD were recovered equally and were well separated by the capillary column so that the earlier-eluting surrogate did not interfere with the quantitation of levels of analyte many-fold lower. Matrix interference contributed < 1% bias in surrogate quantitation. Using surrogate recovery to correct for analyte losses during analysis, accuracy averaged (n = 7) 105% in determining 18 or 45 ppt 2378-TCDD added to fish without detectable bioincurred analyte. Analysis of selected fish with bioincurred 2378-TCDD gave results comparable to earlier work where recovery correction required a second analysis of sample fortified with analyte. With surrogate fortification, repeatability of determination (n = 3 or 4) improved markedly to < 5% relative standard deviation at 37-46 ppt. (Author 's abstract)
JF  - Journal-Association of Official Analytical Chemists Journal JANCA2 Vol. 69, No. 6, p 976-980, November-December 1986. 2 fig, 5 tab, 8 ref.
AU  - Niemann, R A
AD  - Food and Drug Administration Washington, DC. Contaminants Chemistry Div
Y1  - 1986/01//
PY  - 1986
DA  - Jan 1986
KW  - Water Resources Abstracts
KW  - Pollutant identification
KW  - Tissue analysis
KW  - Sample preparation
KW  - Chemical analysis
KW  - Fish
KW  - Electron capture capillary gas chromatography
KW  - Chromatography
KW  - Liquid chromatography
KW  - Dioxin
KW  - Quantitative analysis
KW  - Toxins
KW  - Hazardous materials
KW  - Bioaccumulation
KW  - SW 3010:Identification of pollutants
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Identification of cis- and trans-1,1,2,3 ,4-Pentachloro-4-(1-methylethoxy)-1,3-butadiene Residues in Mississippi River Fish
AN  - 19015048; 8702235
AB  - Tissue analysis of buffalo fish suspected to be contaminated by cis- and trans-isomers of 1,1,2,3 ,4-pentachloro-4-(1-methylethoxy)-1,3-butadiene taken from the Mississippi River at and near St. Louis, MO was performed by using the AOAC multiresidue method for detecting organochlorine and organophosphorus pesticides. In tests on spiked fish, both isomers were quantitatively recovered and a mixture of the isomers was synthesized by reacting hexachlorobutadiene with sodium isopropoxide. Separation of the reaction products provided reference standards of the individual isomers for identification and quantification of the residues. The stereospecificity of the synthesis reaction is discussed and infrared and mass spectral data are presented. (Author 's abstract)
JF  - Journal - Association of Official Analytical Chemists JANCA2 Vol. 69, No. 4, p 586-591, July-August 1986. 4 fig, 3 tab, 15 ref.
AU  - Yurawecz, M P
AU  - Chen, JYT
AU  - Puma, B J
AD  - Food and Drug Administration Washington, DC. Div. of Chemical Technology
Y1  - 1986/01//
PY  - 1986
DA  - Jan 1986
KW  - Water Resources Abstracts
KW  - 1
KW  - 2
KW  - 3
KW  - 4-Pentachloro-4-(1-methylethoxy)-1
KW  - 3-butadiene
KW  - Isomers
KW  - Residues
KW  - Pollutant identification
KW  - Pesticides
KW  - Buffalo fish
KW  - Organophosphorus compounds
KW  - Organochlorine compounds
KW  - Mississippi River
KW  - Contamination
KW  - Mass spectrometry
KW  - SW 3010:Identification of pollutants
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Dioxin Residues in Fish and Other Foods
AN  - 19014009; 8708483
AB  - To determine the presence of dioxin residues in food, several other food commodities as well as fish were analyzed for 2,3,7 ,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), and a number of foods of animal origin were analyzed for residues of the higher-chlorinated dioxins present in pentachlorophenol (PCP), including hexa-, hepta-, and octachlorodibenzo-p-dioxin. Particular attention was paid to the commercial fishing industry at Midland, Michigan and to fish collected from Saginaw Bay and the Great Lakes. Ultratrace residues of 2,3,7,8-TCDD in the edible portion of fish from certain Great Lakes areas and other locations appeared to be associated with the production of chlorinated phenol products and the disposal of dioxin-containing wastes. Levels of 2,3,7,8-TCDD in Saginaw Bay fish appeared to be declining steadily since 1979 when Dow Chemical Co. stopped producing 2,4,5-T. No 2,3,7,8-TCDD residues were found in soybeans, rice, and crawfish from rice-growing areas in Arkansas and Louisiana sprayed with 2,4,5-T herbicide. The presence of 2,3,7,8-TCDD in fish did not appear to be widespread, but rather was localized in areas near 2,4 ,5-trichlorophenol and 2,4,5-T production sites. The presence of higher-chlorinated dioxin residues in eggs and other animal-derived foods collected as market basket samples appeared to be associated with the use of pentachlorophenol in agriculture and industry. (See also W87-08471) (Wood-PTT)
JF  - Chlorinated Dioxins and Dibenzofurans in Perspective, Lewis Publishers, Inc., Chelsea MI. 1986. p 355-365, 6 tab, 21 ref.
AU  - Firestone, D
AU  - Niemann, R A
AU  - Schneider, L F
AU  - Gridley, J R
AU  - Brown, DE
AD  - Food and Drug Administration Rockville, MD
Y1  - 1986
PY  - 1986
DA  - 1986
KW  - Water Resources Abstracts
KW  - Path of pollutants
KW  - Pollutant identification
KW  - Dioxin
KW  - Fish
KW  - Foods
KW  - Polychlorinated hydrocarbons
KW  - Michigan
KW  - Great Lakes
KW  - Saginaw Bay
KW  - Phenols
KW  - Phenolic pesticides
KW  - Herbicides
KW  - SW 3010:Identification of pollutants
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Identification of O, O-Dialkyl-S-Methylphosphorodithioate Residues in Fish
AN  - 18999302; 8700734
AB  - O, O-Dialkyl-S-methylphosphorodithioates were found in Mississippi River buffalo fish caught near several plants and oil refineries in Hartford and Wood River, IL. These chemicals, which have not been previously recognized as environmental or food contaminants, were identified and quantitated by a procedure similar to the Association of Official Analytical Chemists (AOAC) multiresidue method for organochlorine and organophosphorus pesticides, using gas chromatography (GC) with flame photometric detection (FPD). The key to identifing them was a GC/FPD retention time pattern that was virtually the same as that for the diazomethane reaction products of a commercial zinc dialkyl dithiophosphate motor oil additive. GC/mass spectrometry (MS) showed that the compound producing the largest GC/FPD peak contained butoxy groups. The identification of this compound as O, O-di(2-methylpropyl)-S-methylphosphorodithioate (Compound C) was confirmed by GC/MS analysis by comparison with the authentic material. The buffalo fish contained 0.15 ppm Compound C and 0.5 ppm total O, O-dialkyl-S-methylphosphorodithioates. Subsequent analyses of fish from other areas showed that these contaminants were not limited to the Hartford-Wood River area. Lower residue levels of Compound C, ranging from 0.01 to 0.05 ppm, were found in fish from the Mississippi River at Sauget, IL, and from the Delaware River and Newark Bay in NJ. (Author 's abstract)
JF  - Association of Official Analytical Chemists Journal JANCA Vol. 69, No. 2, p 214-217, March-April 1986. 4 fig, 1 tab, 10 ref.
AU  - Yurawecz, M P
AU  - Puma, B J
AD  - Food and Drug Administration Washington, DC. Div. of Chemical Technology
Y1  - 1986/01//
PY  - 1986
DA  - Jan 1986
KW  - Water Resources Abstracts
KW  - Pesticides
KW  - Fish
KW  - Pollutant identification
KW  - Methylphosphorodithioate
KW  - Tissue analysis
KW  - Mississippi River
KW  - Buffalo fish
KW  - Contamination
KW  - Organic matter
KW  - Hartford River
KW  - Wood River
KW  - Illinois
KW  - Delaware River
KW  - Newark Bay
KW  - New Jersey
KW  - Water pollution effects
KW  - Fate of pollutants
KW  - SW 3010:Identification of pollutants
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - RPRT
T1  - Parasites and public health: Is seafood safe?.
AN  - 15836775; 2432910
AB  - Serious human disease may result from ingesting seafood products infected with certain parasites. > 50 species of helminthic parasites have been implicated as producing zoonotic infections resulting from eating raw seafoods. While the majority of these parasitic infections occur outside the US, some human cases have been reported within our borders. One of the most carefully studied diseases induced by a larval nematode is anisakiasis. Humans are infected when they ingest a larval anisakid nematode along with some raw or other inadequately cooked seafoods. The larva may then penetrate into or through the stomach or intestinal wall. In recent years, the number of new cases of anisakiasis in the U.S. has increased. This increase is probably associated with our society's changing dietary habits. Raw seafoods, such as served at sushi bars, are increasing our chances of encountering this disease. The current state of knowledge concerning this disease and preventative measures are discussed.
AU  - Deardorff, T L
A2  - Otwell, WS
A2  - Koburger, JA (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
KW  - food contamination
KW  - parasites
KW  - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality
KW  - FSG-TP-45
KW  - Pisces
KW  - Marine
KW  - USA
KW  - seafood
KW  - human diseases
KW  - parasitic diseases
KW  - quality control
KW  - public health
KW  - Q5 08524:Public health, medicines, dangerous organisms
KW  - Q1 08627:Food quality and standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Summary only.
N1  - Last updated - 2015-03-24
ER  - 



TY  - JOUR
T1  - Malignant melanoma in the printing industry
AN  - 1560139120; 19416246
AB  - In an occupational mortality surveillance study, cause-specific mortality patterns by occupation and industry, among Rhode Island residents who died during the period 1968-78, were examined using the age-standardized proportionate mortality ratio (PMR) method. A noteworthy finding was an elevated PMR for malignant melanoma among white males in the printing industry (PMR = 460, observed deaths = 6, p< .01). When the results of other epidemiologic studies are reviewed in aggregate, they are consistent with this finding. A wide variety of chemicals, some of which are known or suspected human or animal carcinogens, are used in the printing industry. There is also potential exposure to ultraviolet radiation. The hypothesis of a relationship between malignant melanoma and occupational exposures in the printing industry should be investigated further.
JF  - American Journal of Industrial Medicine
AU  - Dubrow, Robert
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 119
EP  - 126
PB  - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL  - 10
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Health & Safety Science Abstracts
KW  - malignant melanoma
KW  - printing industry
KW  - printers
KW  - occupational mortality surveillance
KW  - proportionate mortality ratio
KW  - death certificates
KW  - surveillance
KW  - occupational cancer
KW  - Chemicals
KW  - Mortality
KW  - Reviews
KW  - Ultraviolet radiation
KW  - Printing industry
KW  - Carcinogens
KW  - Mortality patterns
KW  - Occupational exposure
KW  - Melanoma
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2014-09-01
N1  - Last updated - 2014-10-02
N1  - SubjectsTermNotLitGenreText - Chemicals; Mortality; Reviews; Ultraviolet radiation; Printing industry; Carcinogens; Mortality patterns; Occupational exposure; Melanoma
DO  - http://dx.doi.org/10.1002/ajim.4700100203
ER  - 



TY  - JOUR
T1  - Lung cancer and diesel exhaust: A review
AN  - 1560114872; 19416251
AB  - The evidence from animal studies indicates that organic extracts of diesel particulate are mutagenic and carcinogenic. Of four animal inhalation studies, two have been positive and two have been largely negative. The most recent data indicate that inhalation studies may be positive only with high doses of exhaust. Human studies of diesel-exposed occupations have been inconclusive. These studies have focused on truck drivers, bus drivers and garage workers, railroad workers, and heavy equipment operators. Most human studies have not been able to estimate exposure to diesel exhaust. Negative studies have frequently suffered from insufficient potential latency. Positive studies have often failed to control for smoking, and have sometimes involved confounding occupational exposures. In general, the occupational epidemiology of diesel-exposed workers is made difficult by the fact that many of the suspected toxic components of diesel-exhaust are also present in cigarette smoke and in ambient air. There are two ongoing epidemiologic studies in the United States, focusing on railway workers and truck drivers, which attempt to overcome prior difficulties. Preliminary data from the study of truck drivers indicates an excess of lung cancer among workers in the trucking industry compared to the U.S. population, but these data need to be controlled for smoking and analyzed according to diesel exposure
JF  - American Journal of Industrial Medicine
AU  - Steenland, Kyle
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 177
EP  - 189
PB  - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL  - 10
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - Toxicology Abstracts; Health & Safety Science Abstracts
KW  - lung cancer
KW  - diesel exhaust
KW  - epidemiology
KW  - occupation
KW  - Inhalation
KW  - Data processing
KW  - Cigarettes
KW  - Cigarette smoke
KW  - Particulates
KW  - Exhausts
KW  - Smoke
KW  - Workers
KW  - Smoking
KW  - USA
KW  - Epidemiology
KW  - Carcinogenicity
KW  - Railroads
KW  - Reviews
KW  - Trucks
KW  - Diesel
KW  - Diesel engines
KW  - Occupational exposure
KW  - Lung cancer
KW  - X 24380:Social Poisons & Drug Abuse
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2014-09-01
N1  - Last updated - 2014-10-02
N1  - SubjectsTermNotLitGenreText - Inhalation; Smoking; Workers; Data processing; Epidemiology; Reviews; Cigarette smoke; Diesel; Occupational exposure; Lung cancer; Exhausts; Smoke; Cigarettes; Carcinogenicity; Railroads; Trucks; Particulates; Diesel engines; USA
DO  - http://dx.doi.org/10.1002/ajim.4700100208
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944949
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944914
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944376
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 1
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - BOOK
T1  - The FDA total diet study program.
AN  - 15080871; 1883549
AB  - The Total Diet Study, also known as the Market Basket Study, is one of the U.S. Food and Drug Administration's (FDA) programs for monitoring chemical contaminants in foods. It is the only U.S. program that measures a broad range of these chemicals in foods as consumed. The principal objectives are to: determine the dietary intake of pesticides, other industrial chemicals, elements (including heavy metals, radionuclides, and essential minerals); and compare these intakes with Acceptable Daily Intakes (ADI), Recommended Dietary Allowances (RDA), or Estimated Safe and Adequate Daily Dietary Intakes. The program also allows identification of trends, may identify isolated contamination sources, and serves as a final check on the effectiveness of pertinent U.S. regulations and/or initiatives. The emphasis of this program is on pesticides.
AU  - Lombardo, P
A2  - Kopfler, FC
A2  - Craun, GF (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 8
EP  - 148
SN  - 0873710738
KW  - monitoring
KW  - foods
KW  - pollutant detection
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - xenobiotics
KW  - food contamination
KW  - pesticides
KW  - contamination
KW  - X 24120:Food, additives & contaminants
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15080871?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Retrospective cohort mortality study of underground gold mine workers.
AN  - 14907086; 1729195
AB  - A cohort of Homestake gold mine workers lent itself well to the examination of the following important epidemiological questions: whether exposure to the amphibole mineral fibers found in the ore of the gold mine was associated with asbestosrelated diseases such as lung cancer, asbestosis, and mesothelioma; whether exposure to silica dust at the time was associated with increased risk of lung cancer, chronic renal disease, and silica-related nonmalignant respiratory diseases such as silicosis and silicotuberculosis; and whether, as in most mining populations, mortality due to accidents is a potential problem. In a retrospective cohort mortality study of 3,328 gold miners who worked full-time underground for at least 1 yr between 1940 and 1965, there was found to be 861 observed deaths versus 765 expected.
JF  - CANCER RES. MONOGR.
AU  - Brown, D P
AU  - Kaplan, S D
AU  - Zumwalde, R D
AU  - Kaplowitz, M
AU  - Archer, V E
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 335
EP  - 350
VL  - 2
KW  - asbestosis
KW  - Pollution Abstracts
KW  - mining
KW  - epidemiology
KW  - occupational health
KW  - mortality
KW  - risk assessment
KW  - cancer
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mining; occupational health; mortality; cancer; risk assessment; epidemiology
ER  - 



TY  - BOOK
T1  - The use of industrial hygiene data in occupational epidemiology.
AN  - 14807715; 1663360
AB  - The purpose of studies of occupational epidemiology is to investigate the existence and nature of the associations between exposure to physical and chemical agents and outcomes such as morbidity and mortality. While it is very difficult, and some may claim it is impossible, to prove causality between exposure and disease in the occupational setting, the validity of associations observed in epidemiologic studies is determined by estimating the probability that the observed associations could be due to chance alone. This presentation discusses a model which may be used to visualize the components of the exposure-response relationship, with some examples of the use of industrial hygiene data in studies of occupational epidemiology. The model is illustrated and the first portion of the presentation will describe the components of the model, the measurement techniques applicable to each component, and the factors which mediate the pathways between the components.
AU  - Herrick, R F
AU  - Elliott, L J
A2  - Kopfler, F
A2  - Craun, GF (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 18
EP  - 276
KW  - Pollution Abstracts
KW  - physicochemical properties
KW  - mortality
KW  - epidemiology
KW  - morbidity
KW  - occupational health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Transmission of occupational disease to family contacts.
AN  - 14762447; 1612414
AB  - As recognition of occupational illness increases, the scope of health problems related to work widens. An important area of concern is the worker's family, which has been shown to be at increased risk of disease attributable to the hazards previously thought to be relevant only to the worker. Such "para-occupational" disease occurs particularly in spouses and children through transport by the worker of hazardous materials from the worksite into the home. The most common vehicle has been contaminated work clothing brought home for cleaning. Outbreaks of severe illness caused by lead, beryllium, asbestos, and other compounds have been traced to home contamination by industrial dust. In this review, the authors describe reports of "para-occupational" illness that demonstrate the importance of early recognition by medical professionals of this cause of illness and of strict control of the dissemination of hazardous materials outside the workplace.
JF  - American Journal of Industrial Medicine
AU  - Knishkowy, B
AU  - Baker, EL
AD  - Cent. Dis. Control, NIOSH, 1600 Clifton Rd., N.E., Atlanta, GA 30333, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 543
EP  - 550
VL  - 9
IS  - 6
SN  - 0271-3586, 0271-3586
KW  - families
KW  - transmission
KW  - health
KW  - risks
KW  - risk assessment
KW  - man
KW  - PCB compounds
KW  - asbestos
KW  - lead
KW  - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts
KW  - chemicals
KW  - occupational exposure
KW  - public health
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - chemicals; occupational exposure; PCB compounds; public health; asbestos; lead; man
ER  - 



TY  - JOUR
T1  - The analysis of lipopolysaccharide (endotoxin) in meningococcal polysaccharide vaccines by silver staining following SDS-polyacrylamide gel electrophoresis.
AN  - 14755364; 1618301
AB  - A simple physical-chemical method for estimating the lipopolysaccharide (LPS, i.e. endotoxin) content of meningococcal polysaccharide vaccines is described. The low molecular weight LPS was first separated from the high molecular weight polysaccharide by SDS-polyacrylamide gel electrophoresis. The LPS was then selectively visualized by a highly sensitive silver strain which can detect 5 ng of meningococcal LPS. The method can detect concentrations of LPS in meningococcal polysaccharides as low as 0 multiplied by 01, and was used to measure semiquantitatively the LPS in bulk powders of meningococcal polysaccharides and in vaccines in final containers. The LPS in the bulk powders and in the vaccines was also assayed by the gelation of Limulus polyphemus ameobocyte lysate and the results of the two methods were in agreement.
JF  - Biologicals
AU  - Tsai, C-M
AD  - Off. Biol. Res. and Rev., Cent. Drugs and Biol., FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 25
EP  - 33
VL  - 14
IS  - 1
SN  - 0092-1157, 0092-1157
KW  - contamination
KW  - assays
KW  - Neiserria meningitidis
KW  - polysaccharides
KW  - lipopolysaccharides
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology
KW  - vaccines
KW  - endotoxins
KW  - J 02834:Vaccination and immunization
KW  - J 02821:Assays
KW  - A 01099:Bacteria and fungi
KW  - A 01023:Others
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - vaccines; endotoxins
ER  - 



TY  - JOUR
T1  - Drinking and Hispanic-American Family Life: The View Outside the Clinic Walls
AN  - 1474330152
AB  - How family attitudes and practices influence drinking behavior
JF  - Alcohol Health and Research World
AU  - Caetano, Raul
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 26
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Safety Update
AN  - 1474329475
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 70
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Drinking Patterns of Urban and Rural American Indians
AN  - 1474329025
AB  - The Indian drinking party and other drinking practices
JF  - Alcohol Health and Research World
AU  - Weibel-Orlando, Joan C
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 8
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Reader's Exchange
AN  - 1474328688
AB  - Alcoholism Programs Serving Minorities: Administrative Issues
JF  - Alcohol Health and Research World
AU  - Maypole, Donald E
AU  - Anderson, Ruth B
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 62
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474328688?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol Use and Abuse Among Chinese-Americans: Epidemiologic Data
AN  - 1474328230
AB  - How sociocultural changes influence drinking behavior
JF  - Alcohol Health and Research World
AU  - Yu, Elena S H
AU  - Liu, William T
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 14
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474328230?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol-Related Health Risks Among Black Americans: Highlights of the Secretary's Task Force Report on Black and Minority Health
AN  - 1474327521
AB  - Alcohol contributes to the health disparity between minorities and nonminorities
JF  - Alcohol Health and Research World
AU  - Ronan, Laura
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 36
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474327521?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474327316
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 68
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Prevention of Alcohol Abuse Among Black Americans: An Interview with Thomas D. Watts and Roosevelt Wright, Jr.
AN  - 1474327271
AB  - Exploring solutions to the complex problem of prevention
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 40
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin No. 14: Alcohol-Related Morbidity, 1979-1984
AN  - 1474326665
JF  - Alcohol Health and Research World
AU  - Stinson, Fred S
AU  - Williams, Gerald D
AU  - Bertolucci, Darryl
AU  - Noble, John
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 56
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474326665?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Asian-Americans and Alcohol Use: An Exploration of Cultural Differences in Los Angeles
AN  - 1474326048
AB  - Americans of different national origins have different patterns of alcohol consumption
JF  - Alcohol Health and Research World
AU  - Kitano, Harry H L
AU  - Chi, Iris
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 42
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - NIAAA Minority Research Activities
AN  - 1474325620
AB  - Investigating the dynamics of biological, cultural, and ethnic factors
JF  - Alcohol Health and Research World
AU  - Podolsky, Doug
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 4
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Black Church: A Foundation for Recovery
AN  - 1474325596
AB  - Spiritual refuge and agent of social change
JF  - Alcohol Health and Research World
AU  - Prugh, Thomas
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 52
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - News Notes
AN  - 1474324823
JF  - Alcohol Health and Research World
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 69
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Reader's Exchange
AN  - 1474303123
AB  - Hispanic Alcoholics' Children Need Extra Help
JF  - Alcohol Health and Research World
AU  - Figueroa, Ronaldo L
AU  - Oliver-Diaz, Philip
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 66
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Divided Feelings of Black Alcoholic Daughters: An Exploratory Study
AN  - 1474302013
AB  - Recovering black alcoholic COAs - the hows and the whys
JF  - Alcohol Health and Research World
AU  - Larry Brisbane, Frances
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - MIBCA-Sponsored Conference: Groundwork for Future Action
AN  - 1474301608
AB  - A special section on the Minnesota Institute on Black Chemical Abuse conference
JF  - Alcohol Health and Research World
AU  - Grant, David
AU  - Moore, BoisSan
Y1  - 1986///Winter
PY  - 1986
DA  - Winter 1986
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 11
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - CONF
T1  - The impact of new biotechnology on the regulation of drugs and biologics.
AN  - 14714984; 1573306
AB  - The regulatory scope of the Food and Drug Administration (FDA) encompasses many products; a small but increasing fraction of these products are fruits of the new technologies. Advances in biotechnology have occurred rapidly and thus have required close communication between FDA and industry and both the scientific and regulatory levels. This communication has been and continues to be very important for the successful resolution of new and sometimes difficult issues.
JF  - Food drug cosmetic law journal. Chicago IL
AU  - Zoon, K C
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 429
EP  - 432
VL  - 41
IS  - 4
KW  - recombinant DNA
KW  - government policy
KW  - government policies
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - drugs
KW  - biotechnology
KW  - safety regulations
KW  - X 24230:Legislation & recommended standards
KW  - H SE4.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14714984?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - CONF
T1  - Adverse drug experience reporting and product liability.
AN  - 14712974; 1573379
AB  - In 1985, requirements for the submission to the Food and Drug Administration (FDA) of adverse drug experience (ADE) reports by manufacturers were revised. The purpose of this article is briefly to summarize these requirements, their rational, and their implications for product liability.
JF  - Food drug cosmetic law journal. Chicago IL
AU  - Faich, G A
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 444
EP  - 449
VL  - 41
IS  - 4
KW  - reporting
KW  - liability
KW  - man
KW  - government policy
KW  - product liability
KW  - government regulations
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - side effects
KW  - drugs
KW  - safety regulations
KW  - X 24230:Legislation & recommended standards
KW  - H SE4.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
KW  - H SI9.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14712974?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Effects of industrial respirator wear during exercise in subjects with restrictive lung disease.
AN  - 14652013; 1530631
AB  - Few studies have examined the response of individuals with restrictive lung disease (RLD) to respirator wear. Such information should be of theoretical and practical interest when the need to determine fitness to wear respirators is considered. Seventeen females performed progressive submaximal treadmill exercise. Twelve control subjects with total lung capacity (TLC)=5.71 plus or minus .19L (mean plus or minus SEM) and DLCO=25.8 plus or minus 1.0mL/min/mmHg were compared to five RLD subjects with TLC=3.70 plus or minus 0.22 and DLCO=14.5 plus or minus 0.7. Mean age, height and weight were similar. Separate exercise trials were performed with no added resistance (NAR), and with 5 cm H sub(2)O/L/sec inspiratory and 1.5 cm H sub(2)O/L/sec expiratory resistance (R sub(2)) to simulate widely used respiratory masks. comparisons of exercise data were made at an oxygen consumption of 0.8 L/min. With NAR, RLD subjects had significantly higher minute (V)u. sub(E)) (29.0 vs. 21.2 L/min for controls), higher respiratory rate (RR), and lower tidal volume (V sub(T)). Heart rate, end-tidal PCO sub(2) (P sub(et)CO sub(2)), and mouth pressure swing (Poral) were not different from control values. With R sub(2) compared to NAR, the controls had reduced RR and Vu. sub(E); and increased V sub(T), P sub(et) CO sub(2), and Poral. While changes with R sub(2) for the RLD subjects were in the same directions controls, only the increase in Poral was statistically significant.
JF  - American Industrial Hygiene Association Journal
AU  - Hodous, T K
AU  - Boyles, C
AU  - Hankinson, J
AD  - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 176
EP  - 180
VL  - 47
IS  - 3
SN  - 0002-8894, 0002-8894
KW  - respirators
KW  - exercise
KW  - Health & Safety Science Abstracts
KW  - ventilation
KW  - statistical analysis
KW  - respiratory diseases
KW  - H SM10.24:PULMONARY DISEASES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - respiratory diseases; statistical analysis; ventilation
ER  - 



TY  - JOUR
T1  - The use of epidemiology, scientific data, and regulatory authority to determine risk factors in cancer of some organs of the digestive system. 4. Colon cancer.
AN  - 14645158; 1530666
AB  - Colon cancer accounts for over 10% of all cancers diagnosed from 1973 to 1976 in the United States. Many factors have been identified as having a role in its etiology, including the intestinal microflora, colonic mutagens, bile acids, cholesterol, estrogens, and diet. The evidence supporting or refuting the importance of each of these factors and others is discussed. Dietary factors appear to be the most important risk determinants for colon cancer. In particular, a high-fat, low-fiber diet has been most consistently incriminated as a promoting agent of this cancer. The incidence of colon cancer and consumption of total fat and animal protein are highly correlated internationally. However, further epidemiologic studies have given equivocal results. A high-fiber diet has been proposed as being protective against colon cancer although the mechanism of protection remains unclear. A major correlational study has shown that dietary fiber consumption was higher in areas with low incidence of colon cancer than in those areas with high incidence.
JF  - Regulatory Toxicology and Pharmacology
AU  - Tollefson, L
AD  - Epidemiol. and Clin. Toxicol. Unit, Cent. Food Saf. and Appl. Nutr., FDA, Washington, DC 20204, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 24
EP  - 54
VL  - 6
IS  - 1
SN  - 0273-2300, 0273-2300
KW  - United States
KW  - Health & Safety Science Abstracts
KW  - etiology
KW  - epidemiology
KW  - risk assessment
KW  - cancer
KW  - H SM10.21:CANCER
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14645158?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=The+use+of+epidemiology%2C+scientific+data%2C+and+regulatory+authority+to+determine+risk+factors+in+cancer+of+some+organs+of+the+digestive+system.+4.+Colon+cancer.&rft.au=Tollefson%2C+L&rft.aulast=Tollefson&rft.aufirst=L&rft.date=1986-01-01&rft.volume=6&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cancer; etiology; risk assessment; epidemiology
ER  - 



TY  - JOUR
T1  - Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced antinuclear antibodies in mice.
AN  - 14641720; 1505785
AB  - Inducibility of antinuclear antibodies (ANA) by mercuric chloride (HgCl sub(2)) was studied in various strains of mice. High response to the treatment was observed in strains A.SW (H-2 super(s)), A.CA (H-2 super(f)), A.TH (H2 super(t2)), B10.S (H-2 super(s)), DBA/1J (H-2 super(q)), and P/J (H-2 super(p)); strains A.BY (H-2 super(b)), B10.M (H-2 super(f)), and C3H/HeSnJ (H-2 super(k)) showed a low response while strains A/WySn (H-2 super(a)), A/J (H-2 super(a)), A.TL (H-2 super(t1)), BALB/cJ (H-2 super(d)), C57BL/10SnJ (H-2 super(b)), B10.A (H-2 super(a)), and PL/J (H-2 super(u)) did not produce any detectable ANA. Thus, The H-2 super(a) haplotype determines resistance to the treatment regardless of the genetic background; the H-2 super(s) determines susceptibility, while the H-2 super(b) and H-2 super(f) are intermediate haplotypes whose effect depends on the interaction with the background genes. The two drugs tested, gold sodium thiomalate and D-penicillamine, also induced ANA in A.SW mice, while other strains tested resisted this treatment.
JF  - Toxicology and Applied Pharmacology
AU  - Robinson, CJG
AU  - Balazs, T
AU  - Egorov, I K
AD  - Div. Drug Biol., (HFN-176), FDA, 200 C St. SW, Washington, DC 20204, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 159
EP  - 169
VL  - 86
IS  - 2
SN  - 0041-008X, 0041-008X
KW  - nucleus
KW  - induction
KW  - mercuric chloride
KW  - gold sodium thiomalate
KW  - penicillamine
KW  - mice
KW  - Toxicology Abstracts
KW  - antibodies
KW  - antirheumatic agents
KW  - X 24151:Acute exposure
KW  - X 24111:Acute exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - antirheumatic agents; antibodies
ER  - 



TY  - CONF
T1  - Reevaluation of Monier-Williams method for determining sulfite in food.
AN  - 14633887; 1505285
AB  - The Monier-Williams distillation procedure has a long history of successful use for determining sulfite in fruit products and wine; however, a systematic evaluation of its accuracy and precision with other food matrices has not been undertaken. The authors found that the Monier-Williams distillation yielded > 90% recovery of sulfite added to foods such as table grapes, hominy, dried mangos, and lemon juice. Less than 85% recovery was obtained with broccoli, soda crackers, cheese-peanut butter crackers, mushrooms, and potato chips. These results may, in fact, accurately reflect the residual levels of sulfite if a portion of the sulfite undergoes irreversible reaction with some food components. Analysis of commercial food products gave sulfite levels ranging from 1400 ppm in dried apple slices to 25 ppm in cream sherry.
JF  - Journal of the Association of Official Analytical Chemists
AU  - Warner, C R
AU  - Daniels, D H
AU  - Joe, FL Jr
AU  - Fazio, T
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 3
EP  - 5
VL  - 69
IS  - 1
KW  - residues
KW  - Pollution Abstracts
KW  - sulfites
KW  - distillation
KW  - chemical analysis
KW  - food additives
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - CONF
T1  - Technological aspects of use of sulfiting agents in food.
AN  - 14630592; 1505236
AB  - A review of the current literature indicates that scientific knowledge of sulfiting agents in food is changing rapidly. Many of the old assumptions about usage of sulfiting agents have been put in doubt by new scientific data. Some basic definitions of sulfiting agents and their chemical behavior in food are presented.
JF  - Journal of the Association of Official Analytical Chemists
AU  - Modderman, J P
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 1
EP  - 2
VL  - 69
IS  - 1
KW  - Pollution Abstracts
KW  - sulfites
KW  - chemical analysis
KW  - technology
KW  - food additives
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - PCB, PCDF, and PCDD exposure following a transformer fire: Chicago.
AN  - 14630331; 1502958
AB  - On September 28, 1983, an electrical fire in a transformer vault resulted in the loss of 15 gallons of transformer oil composed of 65% PCBs (Aroclor 1260) and 35% trichlorobenzene and forced the precautionary evacuation of a major Chicago office building. A square foot wipe sample of soot on the vault ceiling contained 28,000 ng total TCDFs, 3,800 ng 2,3,7,8-TCDF, 40,000 ng PCDFs, 33,000 ng HxCDFs, 11,200 ng HpCDFs, 1,238 ng OCDFs, 314 ng HpCDDs, and 127 ng OCDDs. No PCDFs or PCDDs were detected in the blood (detection limit 3--40 ppt) of two fire fighters hospitalized with smoke inhalation nor of two office employees similarly exposed.
JF  - Chemosphere. Vol. 15, no. 9-12. 1986.
AU  - Hryhorczuk, DO
AU  - Orris, P
AU  - Kominsky, J R
AU  - Melius, J
AU  - Burton, W
AU  - Hinkamp, D L
A2  - Hutzinger, O
A2  - Crummett, W
A2  - Karasek, FW
A2  - et al. (eds.).
Y1  - 1986
PY  - 1986
DA  - 1986
KW  - transformers
KW  - Chicago
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - fires
KW  - PCDF
KW  - PCB compounds
KW  - PCDD
KW  - H SE8.26:FIRES IN HOMES AND BUILDINGS
KW  - H SE4.20:POISONS AND POISONING
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Identification of pyrilamine metabolites by ammonia chemical ionization mass spectrometry.
AN  - 14613483; 1484983
AB  - The ammonia chemical ionization mass spectrometric analysis of pyrilamine, the N-oxide of pyrilamine, and related compounds is described. The use of ammonia as the reagent gas produced excellent (M + H) super(+) ions for these compounds. The suitability of this method for the analysis of two rat urinary metabolites of pyrilamine is demonstrated.
JF  - Journal of Analytical Toxicology
AU  - Korfmacher, WA
AU  - Holder, CL
AU  - Gosnell, AB
AU  - Thompson, HC Jr
AD  - FDA, Natl. Cent. Toxicol. Res., Div. Chem., Jefferson, AR 72079, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 142
EP  - 146
VL  - 10
IS  - 4
SN  - 0146-4760, 0146-4760
KW  - metabolites
KW  - identification
KW  - ammonia chemical ionization
KW  - pyrilamine
KW  - Toxicology Abstracts
KW  - antihistamines
KW  - mass spectroscopy
KW  - X 24114:Metabolism
KW  - X 24222:Analytical procedures
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - antihistamines; mass spectroscopy
ER  - 



TY  - JOUR
T1  - Hazard prevention in automated factories.
AN  - 14599590; 1479377
AB  - Some estimates place the current United States industrial robot population at 17,000, with total projected installations estimated at 100,000 by 1990. Yet, like many new technologies, the industrial robot was introduced into the workplace without written robotics safety policy.
JF  - Ohio Monitor
AU  - Collins, J W
AD  - NIOSH, Morgantown, WV, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 8
EP  - 11
VL  - 59
IS  - 10
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - robots
KW  - technology
KW  - automation
KW  - factories
KW  - hazards
KW  - H SI8.13:INSTRUMENTATION, DEVICES AND CONTROLS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - robots; occupational safety; automation; technology; hazards; factories
ER  - 



TY  - JOUR
T1  - The stress of hours of work.
AN  - 14593826; 1478739
JF  - American Industrial Hygiene Association Journal [AM. IND. HYG. ASSOC. J.]. Vol. 47, no. 11. 1986.
AU  - Colligan, MJ
AU  - Tepas, DI
AD  - Div. Biomed. and Behav. Sci., NIOSH, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
VL  - 47
IS  - 11
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts
KW  - performance
KW  - stress
KW  - human factors
KW  - occupational health
KW  - H SI0.7:HUMAN FACTORS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; stress; human factors; performance
ER  - 



TY  - JOUR
T1  - The effects of continued versus discontinued administration of 2-acetylaminofluorene on the morphology and behavior of hepatocellular and urinary bladder tumors in mice.
AN  - 14588569; 1467786
AB  - 2-Acetylaminofluorene (2-AAF) was administered in the feed (60, 75, 100 or 150 ppm) to 3,314 BALB/c female mice for periods of either 9, 12, 15, 24 mon. All mice were killed at 24 mon to compare the effects of continued versus discontinued administration of 2-AAF on morphologic characteristics of hepatocellular and urinary bladder neoplasms. Hepatocellular neoplasms included ratio of hepatocellular adenomas to carcinomas, degree of differentiation and incidence of pulmonary metastases. Characteristics evaluated for the bladder tumors included ratio of local to diffuse carcinomas, ratio of invasiveness to noninvasiveness of the carcinomas, ratio of types of bladder carcinoma and incidence of pulmonary metastases. Differences in the ratio of adenomas to carcinomas, degree of differentiation and incidence of pulmonary metastases were not different between the continued and discontinued group. Although the incidence of bladder carcinomas was higher in the mice on the continued 2-AAF diet, other morphologic and biologic characteristics were similar.
JF  - Journal of Environmental Pathology, Toxicology and Oncology
AU  - Frith, CH
AU  - Kodell, R L
AU  - Farmer, J H
AD  - Pathol. Serv. Project, Dep. Health and Human Serv., FDA, Natl. Cent. Toxicol. Res., Jerrerson, AR 72079, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 17
EP  - 24
VL  - 7
IS  - 1-2
SN  - 0731-8898, 0731-8898
KW  - morphology
KW  - N-2-fluorenylacetamide
KW  - mice
KW  - Toxicology Abstracts
KW  - liver
KW  - tumors
KW  - bladder
KW  - X 24190:Polycyclic hydrocarbons
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - liver; bladder; tumors
ER  - 



TY  - JOUR
T1  - Adverse effects of theophylline-beta agonist interactions.
AN  - 14583996; 1467146
AB  - Beta-adrenergic agonists, when administered alone or concomitantly with methlyxanthines are capable of producing lesions of myocardial necrosis and an increased incidence of cardiac arrhythmias in several species of animals. These drugs, including " beta sub(2)-specific" agonists, also have the potential to produce adverse cardiovascular effects when used clinically. In addition, beta agonists and methylxanthines can interact to potentiate or lessen effectiveness and theoretically increase the risk to the patient. As a result, the extent to which the concomitant administration of these drugs may contribute to adverse clinical effects need further clarification.
JF  - . no. 811. 1986.
AU  - Nicklas, R A
AU  - Balazs, T
AD  - FDA, HFN-160, 18B08, Parklawn Build., 5600 Fisher Lane, Rockville, MD 20857, USA
A2  - Grant, JA
A2  - Ellis, EF (ed)
Y1  - 1986
PY  - 1986
DA  - 1986
IS  - 811
KW  - animals
KW  - beta agonists
KW  - interaction
KW  - theophylline
KW  - Toxicology Abstracts
KW  - necrosis
KW  - arrhythmia
KW  - side effects
KW  - heart
KW  - X 24113:Side effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2015-04-07
ER  - 



TY  - JOUR
T1  - Sensitization induced in guinea pigs with beta-propriolactone-treated serum albumin: Experimental evidence for the cause of allergic reactions in humans receiving human diploid cell rabies vaccines.
AN  - 14583945; 1467103
AB  - beta -Propiolactone-treated (BPL-T) homologous serum albumin caused anaphylaxis in guinea pigs with a frequency and severity equal to that of guinea pigs inoculated with human albumin. Untreated guinea pig serum albumin did not cause any reactions in these animals. Some recipients of current rabies vaccine produced in human diploid cells available in the USA develop systemic allergic reactions, usually following booster immunization. The BLP-T human albumin component of the vaccines was believed to be the cause of the complications. The authors studies support this conclusion.
JF  - International Archives of Allergy and Immunology
AU  - Levenbook, I S
AU  - Merritt, BA
AU  - Fitzgerald, E A
AU  - Elisberg, B L
AD  - Off. Biol. Res. and Review, Cent. Drugs and Biol., FDA, Bethesda, MD 20814, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 110
EP  - 111
VL  - 80
IS  - 1
SN  - 0020-5915, 0020-5915
KW  - acute toxicity
KW  - beta -propiolactone
KW  - guinea-pigs
KW  - albumin
KW  - Immunology Abstracts; Toxicology Abstracts
KW  - disinfectants
KW  - anaphylaxis
KW  - F 06844:General
KW  - X 24111:Acute exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - disinfectants; anaphylaxis
ER  - 



TY  - JOUR
T1  - Comparative in vivo and in vitro genotoxicity studies of airborne particle extract in mice.
AN  - 14573363; 1452128
AB  - The genotoxicity of an acetone extract of locally collected airborne particles was evaluated both in vitro and in vivo using the sister-chromatid exchange (SCE) assay in mice. At the highest concentration (5.36 mg/5 ml culture), the extract caused approximately a 3-fold increase in SCEs over controls in mouse bone marrow and spleen primary cells in vitro. However, the same airborne particle extract did not induce a significant increase in the SCE level over controls in vivo in mouse bone marrow and spleen cells when administered intraperitoneally or through oral gavage. This indicates that bone marrow and spleen primary cell cultures can be used in in vitro genotoxicity studies of complex mixtures, and that the genotoxicity of airborne particles detected in the in vitro system cannot always be detected in vivo with the same cell types.
JF  - Mutation Research
AU  - Krishna, G
AU  - Nath, J
AU  - Soler, L
AU  - Ong, T-M
AD  - NIOSH, Microbiol. Sect., 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 157
EP  - 163
VL  - 171
IS  - 2-3
SN  - 0027-5107, 0027-5107
KW  - in vivo
KW  - in vitro
KW  - extracts
KW  - mice
KW  - Genetics Abstracts; Toxicology Abstracts
KW  - sister chromatid exchange
KW  - airborne particulates
KW  - genotoxicity
KW  - X 24155:Biochemistry
KW  - G 07221:Specific chemicals
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Comparative+in+vivo+and+in+vitro+genotoxicity+studies+of+airborne+particle+extract+in+mice.&rft.au=Krishna%2C+G%3BNath%2C+J%3BSoler%2C+L%3BOng%2C+T-M&rft.aulast=Krishna&rft.aufirst=G&rft.date=1986-01-01&rft.volume=171&rft.issue=2-3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - airborne particulates; genotoxicity; sister chromatid exchange
ER  - 



TY  - JOUR
T1  - Validation of the SOS/Umu test with mutagenic complex mixtures.
AN  - 14568734; 1447377
AB  - The SOS/Umu test, a rapid system for detecting genotoxic agents by monitoring SOS responses, was evaluated with the extracts of 8 mutagenic complex mixtures (airborne particles, coal dust, tobacco snuff, fried beef, fried shredded pork, airborne particles particles from polyurethane plants). Results from the study show that a higher beta -galactosidase activity was found when the enzyme substrate and treated cells were added simultaneously into the enzyme reaction mixture and post-treatment dilution (10 x dilution with fresh medium) and incubation (for 2 h) were incorporated. The post-treatment dilution is necessary to reduce a possible false positive due to the color of test substances. The extracts of all mutagenic complex mixtures tested were found to induce dose-related SOS responses.
JF  - Mutation Research
AU  - Whong, W-Z
AU  - Wen, Y-F
AU  - Stewart, J
AU  - Ong, T-M
AD  - NIOSH, ALOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 139
EP  - 144
VL  - 175
IS  - 3
SN  - 0027-5107, 0027-5107
KW  - validation
KW  - mixtures
KW  - Genetics Abstracts; Toxicology Abstracts
KW  - mutagens
KW  - bioassays
KW  - DNA repair
KW  - G 07220:General theory/testing systems
KW  - X 24221:Toxicity testing
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14568734?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Validation+of+the+SOS%2FUmu+test+with+mutagenic+complex+mixtures.&rft.au=Whong%2C+W-Z%3BWen%2C+Y-F%3BStewart%2C+J%3BOng%2C+T-M&rft.aulast=Whong&rft.aufirst=W-Z&rft.date=1986-01-01&rft.volume=175&rft.issue=3&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - bioassays; DNA repair; mutagens
ER  - 



TY  - JOUR
T1  - Mutagenic activation of the benzidine-based dye Direct Black 38 by human intestinal microflora.
AN  - 14566511; 1451968
JF  - Mutation Research
AU  - Cerniglia, CE
AU  - Zhuo, Z
AU  - Manning, B W
AU  - Federle, T W
AU  - Heflich, R H
AD  - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 11
EP  - 16
VL  - 175
IS  - 1
SN  - 0027-5107, 0027-5107
KW  - activation
KW  - Direct Black 38
KW  - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Toxicology Abstracts
KW  - intestinal microflora
KW  - mutagenicity
KW  - dyes
KW  - X 24155:Biochemistry
KW  - J 02841:Microflora
KW  - G 07221:Specific chemicals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14566511?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mutagenicity; dyes; intestinal microflora
ER  - 



TY  - JOUR
T1  - Occupational asthma in a home pieceworker.
AN  - 14562135; 1445084
AB  - 67-yr-old woman presented to a free-standing medical center with respiratory distress of 1 day's duration. She was found on evaluation to have asthma associated with "dripping" the ends of polyurethane-coated wire into molten solder in the production, in her home, of components for the electronics industry. This process has been known to result in the evolution of isocyanates. The patient's sister had also developed cough and wheeze after she performed similar home piecework. Neither the manufacturer nor the distributors of the wire had provided a warning of its potential respiratory hazards. This episode emphasizes the importance of the occupational history, and of following-back thoroughly on cases of occupational disease. In addition, this episode reminds the authors that home pieceworkers are unlikely to have benefit of advice from industrial hygienists or others skilled in recognizing potentially hazardous situations.
JF  - Archives of Environmental Health
AU  - Liss, G M
AU  - Halperin, W E
AU  - Landrigan, P J
AD  - Div. Surveill., Hazard Eval. and Field Stud., NIOSH, 4676 Columbia Parkway, Cincinnati, OH, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 359
EP  - 362
VL  - 41
IS  - 6
SN  - 0003-9896, 0003-9896
KW  - production
KW  - occupational health
KW  - respiratory pathology
KW  - electronics
KW  - isocyanic acid
KW  - electronic equipment
KW  - man
KW  - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts
KW  - hazards
KW  - asthma
KW  - occupational exposure
KW  - H SI10.8.2:CHEMICALS (CORROSION)
KW  - H SM9.31:INHALATION INJURIES
KW  - H SM6.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; asthma; respiratory pathology; hazards; occupational exposure; electronic equipment; man
ER  - 



TY  - JOUR
T1  - Neurobehavioral evaluation of soil and structural fumigators using methyl bromide and sulfuryl fluoride.
AN  - 14552627; 1437972
AB  - Neurobehavioral functions affected by methyl bromide exposure were evaluated in California structural and soil fumigators using methyl bromide and sulfuryl fluoride. Fumigators using methyl bromide reported a significantly higher prevalence of 18 symptoms consistent with methyl bromide toxicity than did Referents. Consistent differences suggest that even the low levels of methyl bromide found in fumigation today may produce slight neurotoxic effects. Results suggest that the data base for sulfuryl fluoride is inadequate.
JF  - Neurotoxicology
AU  - Anger, W K
AU  - Moody, L
AU  - Burg, J
AU  - Brightwell, W S
AU  - Taylor, B J
AU  - Russo, J M
AU  - Dickerson, N
AU  - Setzer, J V
AU  - Johnson, B L
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 137
EP  - 156
VL  - 7
IS  - 3
SN  - 0161-813X, 0161-813X
KW  - disruption
KW  - methyl bromide
KW  - sulfuryl fluoride
KW  - Toxicology Abstracts; CSA Neurosciences Abstracts
KW  - cognitive ability
KW  - man
KW  - X 24132:Chronic exposure
KW  - N3 11105:Primates
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Neurobehavioral+evaluation+of+soil+and+structural+fumigators+using+methyl+bromide+and+sulfuryl+fluoride.&rft.au=Anger%2C+W+K%3BMoody%2C+L%3BBurg%2C+J%3BBrightwell%2C+W+S%3BTaylor%2C+B+J%3BRusso%2C+J+M%3BDickerson%2C+N%3BSetzer%2C+J+V%3BJohnson%2C+B+L&rft.aulast=Anger&rft.aufirst=W&rft.date=1986-01-01&rft.volume=7&rft.issue=3&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cognitive ability; man
ER  - 



TY  - JOUR
T1  - Determination of protein concentration: A comparison of simple fluorometric and colorimetric methods.
AN  - 14545772; 1431217
AB  - Some of the methods available for measuring protein concentration do not always produce reliable data when certain contaminants are present. The performance of two popular colorimetric methods and a fluorometric technique are compared under conditions which simulate those commonly encountered in practice. The fluorometric technique yields the most accurate results throughout the addition of a panel of shelf reagents. The execution of this technique is described in several configurations including microtiter plate and HPLC formats.
JF  - Biotechniques
AU  - Phelan, MA
AU  - Hall, J W
AU  - Mayner, R E
AD  - Div. Virol., Cent. Drugs and Biol./FDA, 8800 Rockville Pike, Bethesda, MD 20205, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 130
EP  - 136
VL  - 4
IS  - 2
SN  - 0736-6205, 0736-6205
KW  - colorimetry
KW  - comparison
KW  - fluorometry
KW  - proteins
KW  - Microbiology Abstracts B: Bacteriology
KW  - J:20320
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2015-03-24
ER  - 



TY  - JOUR
T1  - A survey of aspirin use and Reye's Syndrome awareness among parents.
AN  - 14545544; 1427962
AB  - A national telephone survey of 1,155 parents of children 19 years of age and younger solicited patterns of medication use during episodes of childhood flu and chicken pox. During the previous two years, 6 per cent of the parents whose children had chicken pox and 16 per cent of parents whose children had flu administered aspirin. Approximately 12 per cent of the total sample said they would give their child aspirin if their child were to get the flu or chicken pox today. About half (53 per cent) were aware of the contraindication against aspirin use and 40 per cent could spontaneously recall the name Reye's Syndrome (RS). When measured by a recognition test, 84 per cent of the sample said they had heard of RS. People who continued to believe that aspirin was an appropriate medication were more likely to have treated older children. The RS contraindication for aspirin should be emphasized for teenagers in future public informational programs.
JF  - American Journal of Public Health
AU  - Morris, LA
AU  - Klimberg, R
AD  - Drug Labeling, Educ. and Res. Branch, FDA, HFN-246, 5600 Fishers Lane, Rockville, MD 20857, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 1422
EP  - 1424
VL  - 76
IS  - 12
SN  - 0090-0036, 0090-0036
KW  - Reye's Syndrome
KW  - aspirin
KW  - Health & Safety Science Abstracts
KW  - surveys
KW  - public health
KW  - H SM3.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=A+survey+of+aspirin+use+and+Reye%27s+Syndrome+awareness+among+parents.&rft.au=Morris%2C+LA%3BKlimberg%2C+R&rft.aulast=Morris&rft.aufirst=LA&rft.date=1986-01-01&rft.volume=76&rft.issue=12&rft.spage=1422&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - surveys; public health
ER  - 



TY  - JOUR
T1  - Microbial transformation of 6-nitrobenzo(a)pyrene.
AN  - 14541848; 1432698
AB  - The fungal metabolism of the potent mutagenic and carcinogenic nitropolycyclic aromatic hydrocarbon (nitro-PAH) 6-nitrobenzo(a)pyrene (6-NO sub(2)-BaP) was investigated. Cunninghamella elegans) was incubated with 6-NO sub(2)-BaP for periods ranging between 1 and 7 d, and the metabolites formed were separated by high performance liquid chromatography and identified by their UV-visible absorption, mass, and super(1)H nuclear magnetic resonance spectra. C. elegans) metabolized 6-NO sub(2)-BaP to glucoside and sulfate conjugates of 1- and 3-hydroxy 6-NO sub(2)-BaP and suggests that glycosylation and sulfation reactions may represent detoxification pathways in the fungal metabolism of nitro-PAHs. Experiments using (G- super(3)H)-6-NO sub(2)-BaP indicated that C. elegans) metabolized 62% of 6-NO sub(2)-BaP within 168 h.
JF  - Journal of Toxicology and Environmental Health
AU  - Millner, G C
AU  - Fu, P P
AU  - Cerniglia, CE
AD  - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 519
EP  - 530
VL  - 19
IS  - 4
SN  - 0093-4108, 0093-4108
KW  - metabolism
KW  - detoxification
KW  - 6-nitrobenzo(a)pyrene
KW  - Cunninghamella elegans
KW  - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology
KW  - A 01016:Microbial degradation
KW  - K 03098:Spoilage & biodegradation
KW  - W 30530:Environment and pollution
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Microbial+transformation+of+6-nitrobenzo%28a%29pyrene.&rft.au=Millner%2C+G+C%3BFu%2C+P+P%3BCerniglia%2C+CE&rft.aulast=Millner&rft.aufirst=G&rft.date=1986-01-01&rft.volume=19&rft.issue=4&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Cunninghamella elegans
ER  - 



TY  - RPRT
T1  - Smoking and health. A national status report.
AN  - 14531917; 1427122
AB  - The report contains information on federal and nonfederal smoking and health research efforts; a review of the smoking information and education activities at the national, state and local levels, a summary of the federal and state legislation pertaining to smoking and health, a brief analysis of smoking prevalence over the past 30 years, and a review of smoking intervention efforts with emphasis on those interventions which appear to be most promising.
JF  - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, ROCKVILLE, MD (USA). 1986.
Y1  - 1986
PY  - 1986
DA  - 1986
PB  - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, ROCKVILLE, MD (USA)
KW  - report
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - toxicology
KW  - epidemiology
KW  - cigarettes
KW  - public health
KW  - H SG0:MONOGRAPHS, CONFERENCES, SYMPOSIA, DICTIONARIES,ENCYCLOPEDIA, BIBLIOGRAPHIES
KW  - H SE4.26:DRUGS AND ALCOHOL
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Smoking+and+health.+A+national+status+report.&rft.title=Smoking+and+health.+A+national+status+report.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Developmental neurotoxicology of in utero exposure to industrial solvents in experimental animals.
AN  - 14527984; 1423626
AB  - Relatively few solvents have been examined for developmental neurotoxicology. Although most of the studies have not been replicated, the majority of the solvents tested have produced significant differences from controls. Many used inhalation, which is often the most likely route of occupational or environmental exposure. The majority have extended the exposure for much of gestation of rats. The extensive usage of solvents and the proportion of those tested which have produced positive effects (although admittedly some not at environmentally-relevent exposure concentrations), make a strong case for additional testing of industrial solvents for developmental neurotoxicology.
JF  - Neurotoxicology. Vol. 7, no. 2. 1986.
AU  - Nelson, B K
AD  - Div. Biomed. and Behav. Sci., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
A2  - Tilson, HA
A2  - Cranmer, JM (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
VL  - 7
IS  - 2
SN  - 0161-813X, 0161-813X
KW  - industrial
KW  - Toxicology Abstracts; CSA Neurosciences Abstracts
KW  - reviews
KW  - solvents
KW  - development
KW  - neurotoxicity
KW  - N3 11104:Mammals (except primates)
KW  - N3 11044:Mammals (except primates)
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - solvents; neurotoxicity; development; reviews
ER  - 



TY  - JOUR
T1  - Ozone enhancement of platinum asthma in a primate model.
AN  - 14527316; 1423471
AB  - Three groups of adult male cynomolgus monkeys (Macaca fascicularis ) were exposed to either 200 mu g/m super(3) ammonium hexachloroplatinate ((NH sub(4)) sub(2)PtCl sub(6)) concurrently with 1 ppm ozone (O sub(3)), or to 1 ppm O sub(3) only. Baseline pulmonary function was not significantly affected by the exposure regimens; however, the combination of exposure to O sub(3) and (NH sub(4)) sub(2)PtCl sub(6) significantly reduced the concentration of platinum (Pt) salt and methacholine necessary to increase average pulmonary flow resistance (RL) 200% (EC sub(200) RL). Platinum and methacholine EC sub(200) RL values were highly correlated for both Pt-exposed groups after exposure. The data indicated that combined O sub(3) and Pt exposure significantly increased specific (Pt) and nonspecific (methancholine) bronchial hyperreactivity more often than did exposure to either O sub(3) or the Pt salt alone. Combined O sub(3) plus Pt exposure also significantly increases the incidence of positive Pt skin tests when compared with the other exposure groups. Similar to the human experience, radioallergosorbent testing (RAST) for Pt-specific antibodies was not as direct skin testing in identifying allergic persons.
JF  - American Journal of Respiratory and Critical Care Medicine
AU  - Biagini, R E
AU  - Moorman, W J
AU  - Lewis, T R
AU  - Bernstein, IL
AD  - NIOSH, Exp. Toxicol. Branch, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 719
EP  - 725
VL  - 134
IS  - 4
SN  - 0003-0805, 0003-0805
KW  - association
KW  - platinum
KW  - ozone
KW  - monkeys
KW  - Toxicology Abstracts
KW  - Macaca fascicularis
KW  - asthma
KW  - X 24162:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Macaca fascicularis; asthma
ER  - 



TY  - JOUR
T1  - Association of erythrocyte protoporphyrin with blood lead level and iron status in the second National Health and Nutrition Examination Survey, 1976-1980.
AN  - 14527160; 1423192
AB  - Measurement of protoporphyrin IX in the circulating erythrocyte (EP) has been used to index the extent of lead exposure and iron deficiency. The association of iron status and blood lead level with the level of EP in whole blood for persons ages 6 months through 74 years in the general U.S. population has been investigated by using data obtained in the second National Health and Nutrition Examination Survey. Iron status was defined as a function of percentage transferrin saturation (%TS) and total iron-binding capacity (TIBC). Both low iron status (%TS less than or equal to 16.0 or TIBC greater than or equal to 450 mu g/dl serum) and elevated blood lead levels ( greater than or equal to 30 mu g/dl) were associated with increased EP concentrations.
JF  - Environmental Research
AU  - Mahaffey, K R
AU  - Annest, J L
AD  - NIOSH, DSDTT, C-15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 327
EP  - 338
VL  - 41
IS  - 1
SN  - 0013-9351, 0013-9351
KW  - concentration
KW  - relationship
KW  - protoporphyrin
KW  - man
KW  - lead
KW  - blood analysis
KW  - iron
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - hematology
KW  - blood
KW  - nutrition
KW  - erythrocytes
KW  - H SM9.8.6:DIET
KW  - X 24222:Analytical procedures
KW  - X 24165:Biochemistry
KW  - H SE4.8.6:DIET
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - lead; blood; erythrocytes; blood analysis; iron; nutrition; hematology; man
ER  - 



TY  - BOOK
T1  - Medical screening in the workplace: Proposed principles.
AN  - 14496625; 1410477
AB  - Medical screening and biological monitoring are two techniques in a continuum of practices used to prevent occupational disease. Medical screening is the examination of workers for pathological conditions. Biological monitoring is the examination of the worker for the presence of an intoxicant or its metabolite. These techniques are common in industry, and are frequently components of health standards recommended by the National Institute for Occupational Safety and Health (NIOSH) to the Occupational Safety and Health Administration. However, an underlying set of principles for medical screening and biological monitoring in the workplace has not been delineated. In this paper, a modification of the principles for screening in the community is proposed that will be more appropriate to the workplace. This modified set of principles is not a statement of the policy of NIOSH on this important subject, but rather a presentation of the author's views as a starting point for dialogue on these issues.
JF  - J. OCCUP. MED. Vol. 28, no. 8. 1986.
AU  - Halperin, W E
AU  - Ratcliffe, J
AU  - Frazier, T M
AU  - Wilson, L
AU  - Becker, S P
AU  - Schulte, P A
A2  - Halperin, WE
A2  - Schulte, PA
A2  - Greathouse, DG (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
KW  - biology
KW  - Health & Safety Science Abstracts
KW  - pathology
KW  - monitoring methods
KW  - diseases
KW  - occupational health
KW  - H SI0.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - A proportionate mortality study of granite cutters.
AN  - 14494418; 1407265
AB  - Several recent studies (animal and human) have suggested an association between lung cancer and silica exposure. To test the hypothesis, the authors have studied death benefit records of 1,905 members of the Granite Cutters Union. A proportionate mortality analysis (PMR) was conducted, using U.S. deaths as a comparison population. For lung cancer a slight but nonsignificant excess was observed (97 obs, 81.1 exp, PMR = 1.19, 95% CI 0.97-1.46). Lung cancer mortality also failed to show any trend with either calendar time or duration of exposure. Although no significant excess of lung cancer was observed for the entire silica-exposed cohort, there was an indication that those who were silicotic had an excess risk of lung cancer, based on a review of contributing causes on the death certificate.
JF  - American Journal of Industrial Medicine
AU  - Steenland, K
AU  - Beaumont, J
AD  - Mailstop R-15, NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 189
EP  - 201
VL  - 9
IS  - 2
SN  - 0271-3586, 0271-3586
KW  - workers
KW  - epidemiology
KW  - granite
KW  - silicon dioxide
KW  - Toxicology Abstracts
KW  - lung
KW  - occupational exposure
KW  - man
KW  - carcinoma
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; lung; carcinoma; man
ER  - 



TY  - JOUR
T1  - Critique of 1985 ACGIH report on particle size-selective sampling in the workplace.
AN  - 14494289; 1411068
AB  - The criteria recently proposed by ACGIH for judging the acceptability of respirable and other dust fraction samplers are analyzed. Implications on the sampling of workplace aerosol are determined. With the consideration of both bias and impecision, the overall accuracy limited by the criteria is estimated for the sampling of coal mine dust as characterized by various research. The accuracy limits thus found appear to be excessively broad. As an example with actual workplace dust distributions in the sampling of a single aerosol with respirable dust concentration near 2 mg/m super(3), two samplers acceptable according to the proposed criteria could be found giving respirable dust measurements equal to 0.71 mg/m super(3) and 4,3 mg/m super(3). Large variation in samplers acceptable according to the criteria is found for many other distributions as well; this indicates that tighter requirements are necessary. Seldom attained are both the single-sample plus or minus 25% accuracy at the 95% confidence level required of sampling/analytical methods endorsed by the National Institute for Occupational Safety and Health (NIOSH) and the tighter ISO dust fraction measurement requirement that 67% of the measurements of a sampled dust fall within 10% of a true value. Suggestions are given for sharpening the criteria without eliminating all samplers from acceptability.
JF  - American Industrial Hygiene Association Journal
AU  - Bartley, DI
AU  - Doemeny, L J
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 443
EP  - 447
VL  - 47
IS  - 8
SN  - 0002-8894, 0002-8894
KW  - monitoring measurements
KW  - Pollution Abstracts
KW  - particle size
KW  - coal
KW  - dust
KW  - occupational health
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - particle size; dust; coal; occupational health
ER  - 



TY  - JOUR
T1  - Size and concentration measurement of an industrial aerosol.
AN  - 14494186; 1411128
AB  - Several real-time particle sizing instruments were evaluated for measuring the size distribution and concentration of the aerosol produced during the high speed grinding of gray iron castings. Aerosol was sampled in the airstream entrained by the motion of a spinning grinding wheel in a pilot grinding operation. Measurement methods based on differing physical principles were selected for evaluation and compared: particle inertia (aerodynamic particle sizer and quartz crystal microbalance cascade impactor); light scattering (laser aerosol spectrometer); and projected-aerea microscopy (scanning electron microscope). Inferences of aerodynamic diameter based on measurements by the laser aerosol spectrometer consistently undersized that determined by the aerodynamic particle sizer by a factor of 1.5. Estimates of aerodynamic diameters from projected area diameters determined by scanning electron microscopy differed from those obtained by the aerodynamic particle sizer by a factor of 2. Differences appeared to be a non-linear function of particle diameter. Estimates of respirable mass determined from mass-weighted particle size spectra varied by a factor of 6 between the largest estimate (scanning electron microscope) and the smallest estimate (laser aerosol spectrometer).
JF  - American Industrial Hygiene Association Journal
AU  - O'Brien, D
AU  - Baron, P
AU  - Willeke, K
AD  - Div. Phys. Sci. and Eng., NIOSH, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 386
EP  - 392
VL  - 47
IS  - 7
SN  - 0002-8894, 0002-8894
KW  - monitoring measurements
KW  - Pollution Abstracts
KW  - particle size
KW  - measuring instruments
KW  - aerosols
KW  - spectroscopy
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - particle size; aerosols; measuring instruments; spectroscopy
ER  - 



TY  - JOUR
T1  - Occupational lead poisoning in Ohio: Surveillance using workers' compensation data.
AN  - 14493949; 1407249
AB  - To determine the utility of workers' compensation (WC) data in a system for the surveillance of occupational lead poisoning, the authors reviewed workers' compensation claims for lead poisoning in Ohio. For the period 1979 through 1983, 92 (81 per cent) of the 114 claims attributed to lead met their case definition of lead poisoning. The likelihood that a company had a case of lead poisoning was strongly correlated with the number of claims against the company. Thirty companies accounted for the 92 cases; two companies accounted for 49 per cent of these. Inspection by the Occupational Safety and Health Administration (OSHA) occurred at 14 of these companies, all of which were cited for violations of the OSHA lead standard. Comparison of the Standard Industrial Classification (SIC) codes for the 14 companies inspected by OSHA with the 15 companies not inspected by OSHA revealed that OSHA inspected battery manufacturers, non-ferrous foundries, secondary smelters, and primary lead smelters, but not bridge painters, manufacturers of electronic components, mechanical power transmission equipment, pumps, and paints, nor a sheriff's office where firing range slugs were remelted to make new bullets.
JF  - American Journal of Public Health
AU  - Seligman, P J
AU  - Halperin, W E
AU  - Mullan, R J
AU  - Frazier, T M
AD  - Industry-wide Studies Branch, Div. Surveill. Hazard Eval., and Field Serv., NIOSH, R-10, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 1299
EP  - 1302
VL  - 76
IS  - 11
SN  - 0090-0036, 0090-0036
KW  - Ohio
KW  - occupational health
KW  - lead
KW  - man
KW  - Toxicology Abstracts; Pollution Abstracts
KW  - surveys
KW  - USA, Ohio
KW  - occupational exposure
KW  - X 24162:Chronic exposure
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - USA, Ohio; occupational health; lead; surveys; occupational exposure; man
ER  - 



TY  - BOOK
T1  - Medical surveillance for hazardous waste workers.
AN  - 14493714; 1411047
AB  - The efforts to clean up hazardous waste disposal sites have led to an increasing number of workers involved in these activities. Industrial hygiene surveys have demonstrated that these workers are potentially exposed to low levels of multiple contaminants during the work day and to high levels of some contaminants for very short time periods. Personal protective equipment and work practices are important components in protecting workers from these exposures. Medical monitoring for these workers is problematic. While monitoring for the potential health effects of these multiple exposures may be useful, any attempt to monitor for possible health effects of all potential exposures could lead to a long array of medical tests. The utility and effectiveness of this approach is doubtful. Screening for a worker's physical ability to conduct hazardous waste cleanup jobs while he is wearing protective equipment is also important and may cause difficulties due to our limited knowledge in this area. These issues will be discussed in the context of various programs designed to monitor these workers.
JF  - J. OCCUP. MED. Vol. 28, no. 8. 1986.
AU  - Melius, J M
A2  - Halperin, WE
A2  - Schulte, PA
A2  - Greathouse, DG (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - occupational health
KW  - hazardous materials
KW  - surveys
KW  - contamination
KW  - disposal sites
KW  - H SE3.23:WASTE DISPOSAL
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - P 4000:WASTE MANAGEMENT
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - Use of data from X-ray screening program for coal workers to evaluate effectiveness of 2 mg/m super(3) coal dust standard.
AN  - 14493689; 1411243
AB  - The National Institute for Occupational Safety and Health administers the X-ray Screening Program for underground coal miners, a program mandated by the Federal Mine Health and Safety Act of 1969. The screening file, with over 200,000 x-ray films, affords an excellent source for the study of prevalence and progression of Coal Workers' Pneumoconiosis. Two epidemiological analyses have recently been completed. One, a prevalence study of miners with 10 or fewer years of mining tenure, converted screening readings to median epidemiological readings. Converted prevalences were 0.44% for the group with 0 to 1 year tenure and 0.79% for the group with 1 to 9 years tenure. This result is similar to prevalence observed in a study of nonexposed blue collar workers. A second analysis reread x-ray films of a subgroup of 1,834 repeat miners with roughly 9 years exposure only under mandated dust standards. Net progression from category 0/0 was observed to be 1.2%. This value is consistent with 1.9%, based on an average dust exposure, predicted by British research. Results must be interpreted in light of several possible sources of bias.
JF  - J. OCCUP. MED. Vol. 28, no. 8. 1986.
AU  - Althouse, R
AU  - Attfield, M
AU  - Kellie, S
A2  - Halperin, WE
A2  - Schulte, PA
A2  - Greathouse, DG (eds)
Y1  - 1986
PY  - 1986
DA  - 1986
KW  - X-ray radiation
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - statistical analysis
KW  - occupational health
KW  - coal
KW  - dust
KW  - P 0000:AIR POLLUTION
KW  - H SI2.8.7:DUST
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Control of air contaminant at mixers and mills used in tire manufacturing.
AN  - 14493073; 1410577
AB  - The National Institute for Occupational Safety and Health (NIOSH) has completed and evaluation of control techniques for airborne vapors and particulates in tire manufacturing. As part of this evaluation, Banbury) mixers and mills were studied. This equipment is used to mix elastomers, carbon black, oil and other ingredients into a homogeneous mixture. These mixing and milling operations normally generate aerosols. Control of these air contaminants may be accomplished by using the following: local exhaust ventilation, equipment configuration and material substitution. Results of personal sampling for total aerosols at Banbury mixers showed the geometric means of mixer operators' exposures at five plants ranged from 0.08 to 1.54 mg/m super(3). Similar sampling at three plants for milling operations showed the geometric means of milling operators' exposures ranged from 0.20 to 1.22 mg/m super(3).
JF  - American Industrial Hygiene Association Journal
AU  - Heitbrink, WA
AU  - McKinnery, WN Jr
AD  - U.S. DHHS, Public Health Serv., Cent. Dis. Control, NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 312
EP  - 321
VL  - 47
IS  - 6
SN  - 0002-8894, 0002-8894
KW  - vapor
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - occupational health
KW  - particulates
KW  - ventilation
KW  - air quality
KW  - contaminants
KW  - rubber products
KW  - tires
KW  - H ST2.27:TIRES
KW  - P 0000:AIR POLLUTION
KW  - H SI2.28:RUBBER FACTORIES
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - tires; occupational health; rubber products; air quality; contaminants; ventilation; particulates
ER  - 



TY  - JOUR
T1  - Murine bone marrow culture system for cytogenetic analysis.
AN  - 14488024; 1390965
AB  - A mouse bone marrow culture system for examining genotoxicity of agents by first exposing animals in vivo then growing cells in vitro is presented. This assay can also be used for in vitro and/or for the in vivo and in vitro comparative cytogenetic studies. The protocol involves culturing of approximately 1,000,000 nucleated cells obtained from mice tibia and femora in 5 ml of Ham's F-12 medium containing 20% fetal bovine serum, 10% whole uterus extract from pregnant mice and 1% penicillin-streptomycin. The use of flasks and mouse uterus extract for culturing and important steps for higher mitotic yield. The addition of 20 mu M BrdU for 24 h helps in the differentiation of sister chromatids for sister-chromatid exchange (SCE) analysis.
JF  - Mutation Research
AU  - Krishna, G
AU  - Nath, J
AU  - Ong, T
AD  - NIOSH, Microbiol. Sect., 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 91
EP  - 99
VL  - 164
IS  - 2
SN  - 0027-5107, 0027-5107
KW  - cell culture
KW  - assays
KW  - mice
KW  - Toxicology Abstracts; Genetics Abstracts
KW  - toxicity testing
KW  - mutation
KW  - bone marrow
KW  - G 07220:General theory/testing systems
KW  - X 24222:Analytical procedures
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - bone marrow; mutation; toxicity testing
ER  - 



TY  - JOUR
T1  - Assessment of the contamination of a multibuilding facility by polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans.
AN  - 14486308; 1377026
AB  - This study describes a unique site of polychlorinated biphenyl (PCB), polychlorinated dibenzo-p-dioxin (PCD-D), and polychlorinated dibenzofuran (PCDF) contamination. The extent of the contamination was characterized by the results of the analyses of several hundred surface wipe samples. In addition, smaller numbers of air samples and dust samples were analyzed. The hypothesis that octachlorodibenzo-p-dioxin (OCDD) can be used as a marker for all the PCDDs and PCDFs and that total PCBs can be used as a marker for the semiquantitative estimation of the PCDDs and PCDFs was tested. The hypothesis was validated in this application because the ratios of OCDD/heptachlorodibenzo-p-dioxins (HpCDDs) and PCBs/OCDD in wipe and dust samples showed good agreement and were reasonably consistent. The data from the contamination assessment indicate that the route of contamination of the complex was through the fresh air intake vents and that the source was the on-site incinerator.
JF  - Environmental Science and Technology
AU  - Thompson, HC Jr
AU  - Kendall, D C
AU  - Korfmacher, WA
AU  - Rowland, K L
AU  - Rushing, L G
AU  - Chen, J J
AU  - Kominsky, J R
AU  - Smith, L M
AU  - Stalling, D L
AD  - Natl. Cent. Toxicol. Res., FDA, DHHS, Jefferson, AR 72079, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 597
EP  - 603
VL  - 20
IS  - 6
SN  - 0013-936X, 0013-936X
KW  - pollutant detection
KW  - Pollution Abstracts
KW  - dust
KW  - PCDF
KW  - buildings
KW  - air sampling
KW  - PCB compounds
KW  - contamination
KW  - PCDD
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - buildings; PCB compounds; PCDD; PCDF; dust; contamination; air sampling
ER  - 



TY  - JOUR
T1  - Use of tracer technique for industrial exhaust hood efficiency evaluation - where to sample?.
AN  - 14485445; 1381500
AB  - A tracer gas technique using sulfur hexafluoride (SF sub(6)) was developed for the evaluation of industrial exhaust hood efficiency. In addition to other parameters, accuracy of this method depends on proper location of the sampling probe. The sampling probe should be located in the duct at a minimum distance, the SF sub(6) dispersion in the duct in fully developed turbulent flow was studied at four duct configurations frequently found in industry: straight duct, straight duct-side branch, straight duct-one elbow, and straight duct-two elbows combinations. Based on the established SF sub(6) dispersion factor, the minimum sampling distances were determined as follows: for straight duct, at least 50 duct diameters; for straight duct-side branch combination, at least 25 duct diameters; for straight duct-one elbow combination, 7 duct diameters; and for straight duct-two elbow combination, 4 duct diameters. Sampling at (or beyond) these distances minimizes the error caused by the non-homogenous dispersion of SF sub(6) in the duct and contributes to the accuracy of the tracer gas technique.
JF  - American Industrial Hygiene Association Journal
AU  - Hampl, V
AU  - Niemelae, R
AU  - Shulman, S
AU  - Bartley, D L
AD  - NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 281
EP  - 287
VL  - 47
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - pollutant dispersion
KW  - Pollution Abstracts
KW  - tracers
KW  - industrial emissions
KW  - emission control
KW  - gases
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - tracers; gases; emission control; industrial emissions
ER  - 



TY  - JOUR
T1  - The characterization of a black light device: A hazard evaluation process.
AN  - 14471650; 1378182
AB  - The results of an occupational hazard evaluation process to assess the potential ultraviolet radiation exposure from broad-band sources of optical radiation are compared with the American Conference of Governmental Industrial Hygienists (ACGIH) guidelines for occupational exposure to ultraviolet radiation. A black light fluorescent lamp device, evaluated according to these criteria, exceeded the ACGIH-TLV) for UVA and UVB. Design modifications resulted in acceptable occupational exposure levels without compromising the performance of the device.
JF  - American Industrial Hygiene Association Journal
AU  - Ellingson, O L
AD  - U.S. DHHS, Public Health Serv., FDA Cent. Dev. Radiol. Health, Div. Phys. Sci., 5600 Fishers Lane, Rockville, MD 20857, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 488
EP  - 490
VL  - 47
IS  - 8
SN  - 0002-8894, 0002-8894
KW  - Pollution Abstracts
KW  - hazards
KW  - performance
KW  - occupational health
KW  - ultraviolet radiation
KW  - P 8000:RADIATION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ultraviolet radiation; hazards; performance; occupational health
ER  - 



TY  - JOUR
T1  - Reproduction study of caffeine administration to male Osborne-Mendel rats.
AN  - 14444651; 1342197
AB  - The potential for caffeine, administered twice daily by gavage in a total dose of 40 or 80 mg/kg/day, to adversely affect the reproductive performance of male rats was investigated. Treatment was continued through 3 wk of serial mating; mating and dosing were terminated concurrently, after which the sires were autopsied and their testes weighed. Controls were treated similarly with distilled water. Significant dose-related differences were detected for sire body weight, but not for testes weight. The majority of the significant effects on the offspring were for those born to the low-dose sires. Statistically significant differences were sporadically detected for the number of pups born and their body weights and survival; however, these differences were not consistently detected in either a dose- or temporal-related fashion. Thus, caffeine appears to have little potential to produce adverse reproductive effects when administered by gavage to male rats at the levels tested in this study.
JF  - Food and Chemical Toxicology
AU  - Whitby, KE
AU  - Collins, TFX
AU  - Welsh, J J
AU  - Black, T N
AU  - O'Donnell, M
AU  - Gray, G C
AU  - Green, S
AU  - West, W L
AD  - Div. Toxicol., FDA, Washington, DC 20204, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 277
EP  - 282
VL  - 24
IS  - 4
SN  - 0278-6915, 0278-6915
KW  - effects on
KW  - caffeine
KW  - rats
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - males
KW  - reproduction
KW  - H SE4.20:POISONS AND POISONING
KW  - X 24180:Social poisons & drug abuse
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - reproduction; males; rats
ER  - 



TY  - JOUR
T1  - Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats.
AN  - 14444021; 1354766
AB  - This study was initiated because of a suspected increase in incidence of lung cancer in antimony smelter workers in England. Three groups of 8-mo-old Wistar-derived rats (90 males and 90 females per group) were exposed by inhalation to either Sb sub(2)O sub(3) (time-weighted average (TWA) 45 mg/m super(3)), Sb ore concentrate (TWA 36 + 40 mg/m super(3)), or filtered air (controls) for 7 h/d, 5 d/wk, for up to 52 wk and sacrificed 20 wk after terminating exposures. Serial sacrifices (5 rats/sex/group) were performed at 6, 9, and 12 mo. Autopsier and histopathological exmainations were performed on all animals. The dusts and animal tissues were analyzed for Sb, arsenic, and other inorganic elements by atomic absorption and proton-induced X-ray emission methods. The most significant findings were the presence of lung neoplasms in 27% of females exposed to Sb sub(2)O sub(3) and 25% of females exposed to Sb ore concentrate. None of the male rats in any group or the female controls developed lung neoplasms.
JF  - Journal of Toxicology and Environmental Health
AU  - Groth, D H
AU  - Stettler, LE
AU  - Burg, J R
AU  - Busey, WM
AU  - Grant, G C
AU  - Wong, L
AD  - Appl. Biol. and Phys. Branch, Div. Biomed. and Behav. Sci., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 607
EP  - 626
VL  - 18
IS  - 4
SN  - 0093-4108, 0093-4108
KW  - exposure
KW  - antimony trioxide
KW  - antimony
KW  - rats
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - inhalation
KW  - carcinogenicity
KW  - carcinogenesis
KW  - X 24165:Biochemistry
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - antimony; carcinogenicity; rats; inhalation; carcinogenesis
ER  - 



TY  - JOUR
T1  - Biotransformation of 1-nitropyrene to 1-aminopyrene and n-formyl-1-aminopyrene by the human intestinal microbiota.
AN  - 14443887; 1354834
AB  - The nitropolycyclic aromatic hydrocarbon 1-nitropyrene (1-NP) is an environmental pollutant, a potent bacterial and mammalian mutagen, and a carcinogen. The metabolism of 1-NP by the human intestinal microbiota was studied using a semicontinuous culture system that simulates the colonic lumen. ( super(3)H)-1-Nitropyrene was metabolized by the intestinal microbiota to 1-aminopyrene (1-AP) and N-formyl-1-aminopyrene (FAP). Twenty-four hours after the addition of ( super(3)H)-1-NP, the formylated compound and 1-AP accounted for 20 and 80% of the total metabolism, respectively. This percentage increased to 66% for FAP after 24 h following 10 d of chronic exposure to unlabeled 1-NP. Both 1-AP and FAP have been shown to be nonmutagenic towards Salmonella typhimurium) TA98, which indicates that the intestinal microflora may potentially detoxify 1-NP.
JF  - Journal of Toxicology and Environmental Health
AU  - Manning, B W
AU  - Cerniglia, CE
AU  - Federle, T W
AD  - Natl. Cent. Toxicol. Res., FDA, Jefferson, AR 72079, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 339
EP  - 346
VL  - 18
IS  - 3
SN  - 0093-4108, 0093-4108
KW  - 1-nitropyrene
KW  - intestinal microflora
KW  - cell culture
KW  - 1-aminopyrene
KW  - N-formyl-1-aminopyrene
KW  - intestine
KW  - Pollution Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts
KW  - detoxification
KW  - bacteria
KW  - polycyclic aromatic hydrocarbons
KW  - X 24190:Polycyclic hydrocarbons
KW  - J 02841:Microflora
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - detoxification; polycyclic aromatic hydrocarbons; bacteria; intestinal microflora; cell culture; intestine
ER  - 



TY  - JOUR
T1  - Interactions of a water extract of cotton bract with dog isolated airway smooth muscle.
AN  - 14443682; 1342022
AB  - In the present study the dog isolated trachealis smooth muscle preparation was employed to examine the ability of a crude, water extract of cotton bracts (CBE) to (1) cause contractile responses mediated by receptors, (2) modify responses of the tissue to a number of excitatory and inhibitory agents, and (3) alter responsiveness of the preparations to electrical field stimulation mediated by intrinsic cholinergic, excitatory nerves and adrenergic, inhibitory nerves. CBE evoked contraction of the tissues by an action that did not involve muscarinic, histamine, or 5-hydroxytryptamine receptors. The maximum tissue responses to exogenous histamine, 5-hydroxytryptamine, and isoproterenol were enhanced significantly in the presence of CBE while those to KCl and methacholine were unaffected. The sensitivities (EC50 values) of the tissues to these agents were not, however, altered by CBE. Contractions induced by cholinergic nerve stimulation were increased in the presence of CBE.
JF  - Journal of Toxicology and Environmental Health
AU  - Fedan, J S
AU  - Franczak
AU  - Cahill, J F
AU  - Kosten, C J
AU  - Morey, P
AU  - Weber, K C
AD  - Physiol. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 57
EP  - 71
VL  - 17
IS  - 1
SN  - 0093-4108, 0093-4108
KW  - cotton bract
KW  - in vitro
KW  - effects on
KW  - dogs
KW  - Toxicology Abstracts
KW  - trachea
KW  - muscles
KW  - occupational exposure
KW  - byssinosis
KW  - X 24155:Biochemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - byssinosis; occupational exposure; trachea; muscles
ER  - 



TY  - JOUR
T1  - Calibration and use of the Aerodynamic Particle Sizer (APS 3300).
AN  - 14435033; 1344761
AB  - The Aerodynamic Particle Sizer (APS) has been in use at the National Institute For Occupational Safety and Health (NIOSH) for over two years, beginning with a prototype model and more recently with a commercial version (Model 3300). The APS has been tested and used in a variety of laboratory and field situation. It has been a very useful instrument for testing aerodynamic sizing devices and provided a much needed means of rapid aerodynamic sizing of particles. Limits to the accuracy of the APS in determining aerodynamic diameter of particles were investigated.
JF  - Aerosol Science & Technology
AU  - Baron, P A
AD  - Monit. Res. Sect., Monit. and Control Res. Branch, Div. Phys. Sci. and Eng., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 55
EP  - 67
VL  - 5
IS  - 1
SN  - 0278-6826, 0278-6826
KW  - calibration
KW  - APS 3300
KW  - Pollution Abstracts
KW  - particle size
KW  - measuring instruments
KW  - aerosols
KW  - laboratory testing
KW  - P 0000:AIR POLLUTION
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=Calibration+and+use+of+the+Aerodynamic+Particle+Sizer+%28APS+3300%29.&rft.au=Baron%2C+P+A&rft.aulast=Baron&rft.aufirst=P&rft.date=1986-01-01&rft.volume=5&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - aerosols; particle size; measuring instruments; laboratory testing
ER  - 



TY  - RPRT
T1  - The health consequences of using smokeless tobacco 1986.
AN  - 14432459; 1342560
AB  - This report discusses the health consequences of smokeless tobacco use. It constitutes a comprehensive review by an Advisory Committee to the Surgeon General of the available scientific literature to determine whether using smokeless tobacco increases the risk of cancer and non-cancerous oral diseases and effects, leads to addiction and dependence, and contributes to other health consequences. After a careful examination of the relevant epidemiologic, experimental, and clinical data, the committee concludes that the oral use of smokeless tobacco represents a significant health risk. It is not a safe substitute for smoking cigarettes. It can cause cancer and a number of noncancerous oral conditions and can lead to nicotine addiction and dependence.
JF  - U.S. GOVERNMENT PRINTING OFFICE, WASHINGTON, DC (USA). 1986.
Y1  - 1986
PY  - 1986
DA  - 1986
PB  - U.S. GOVERNMENT PRINTING OFFICE, WASHINGTON, DC (USA)
KW  - nicotine
KW  - tobacco
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - risk assessment
KW  - cancer
KW  - public health
KW  - H SM3.8.4:DRUGS AND ALCOHOL
KW  - H SE4.26:DRUGS AND ALCOHOL
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14432459?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Rep. No. NIH Publ. No. 86-2874.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Review of the biodistribution and toxicity of the insect repellent N,N-diethyl-m-toluamide (DEET).
AN  - 14432049; 1341202
AB  - A review of the biodistribution and toxicity of the insect repellent N,N-diethyl-m-toluamide (DEET) is presented. Workers using repellent containing this compound may be exposed to greater than 442 g in 6 mo. In human studies, variable penetration into the skin of from 9 to 56% of a topically applied dose and absorption into the circulatory system of approximately 17% have been reported. Excretion of DEET by human was initially rapid but not as complete as in animal models. Neurotoxic effects were observed in workers exposed to 4 g or more per week. Six young girls developed encephalopathies after exposure to unspecified amounts of DEET ranging from small to massive doses. Three of these girls later died. The cause of their death has not been resolved. Because of the lack of information, further research into the absorption, carcinogenicity, and neurotoxic effects is needed.
JF  - Journal of Toxicology and Environmental Health
AU  - Robbins, P J
AU  - Cherniack, M G
AD  - NIOSH, Robert A. Taft Lab., C-15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 503
EP  - 525
VL  - 18
IS  - 4
SN  - 0093-4108, 0093-4108
KW  - disposition
KW  - deet
KW  - repellents
KW  - man
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - toxicity
KW  - occupational exposure
KW  - H SE5.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - X 24131:Acute exposure
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14432049?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - toxicity; occupational exposure; repellents; man
ER  - 



TY  - JOUR
T1  - Robot-related fatality involving a U.S. manufacturing plant employee: Case report and recommendations.
AN  - 14430583; 1341921
AB  - This article presents the salient chracteristics of the first publicy documented robot-related fatality in the United States and summarizes recommendations for both preventing similar accidents and directing future robotic safety research and practice. In July of 1984, a 34-year-old die cast operator with 15 years experience was pinned between the right rear end of a hydraulic robot and a "safety pole". This operator was one of approximately 66 operators employed by the die cast company and was considered by many to be among the most adept at working with the plant's two robots. The major factor contributing to the death of this worker may have been his own behavior; he had been formally trained and instructed not to enter the envelope while the robot was operational. This American fatality has several characteristics in common with reported Japanese robot fatalities.
JF  - Journal of Occupational Accidents
AU  - Sanderson, L M
AU  - Collins, J W
AU  - McGlothlin, J D
AD  - Injury Surveill. Branch, Div. Saf. Res., NIOSH, Cent. Dis. Control, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 13
EP  - 23
VL  - 8
IS  - 1-2
SN  - 0376-6349, 0376-6349
KW  - United States
KW  - die casting
KW  - mechanical handling
KW  - accidents
KW  - ergonomics
KW  - industrial plants
KW  - mortality
KW  - occupational safety
KW  - robots
KW  - Mechanical Engineering Abstracts (ISMEC); Health & Safety Science Abstracts
KW  - H SI0.4:ACCIDENT INVESTIGATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Special issue: Safety of robots and automated manufacturing systems.
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - robots; accidents; mortality; occupational safety; ergonomics; industrial plants
ER  - 



TY  - JOUR
T1  - An investigation of mortality from cancer and other causes of death among workers employed at an east Texas chemical plant.
AN  - 14430348; 1343480
AB  - The cause-specific mortality of 2,510 males employed at an east Texas chemical plant was examined in a historical prospective study to evaluate a suspected increase in deaths from multiple myeloma and brain cancer. Potential exposures from chemicals, either used in manufacturing processes or produced during the study period 1952-1977, included the fuel additive tetraethyl lead, ethylene dibromide and dichloride, inorganic lead, and vinyl chloride monomer. Overall mortality for all workers (156 observed vs. 211.14 expected) and for workers first employed between 1952 and 1959 (131 observed vs. 167.33 expected) when tetraethyl lead was the single major product was lower than expected when compared to the United States general population. There were no significant increases in mortality from malignancies or other causes of death. The deficits may be due to the small number of total deaths, and the low power for detecting excess risk of mortality from multiple myeloma, brain cancer, or other rare causes of death; lack of complete workplace exposure data for production workers; and the absence of historical measurements on the extent of environmental exposure to tetraethyl lead and other chemicals.
JF  - Archives of Environmental Health
AU  - Sweeney, M H
AU  - Beaumont, J J
AU  - Waxweiler, R J
AU  - Halperin, W E
AD  - NIOSH, 4676 Columbia Parkway, Robert A. Taft Lab., Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 23
EP  - 28
VL  - 41
IS  - 1
SN  - 0003-9896, 0003-9896
KW  - Texas
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational health
KW  - chemical industry
KW  - mortality
KW  - cancer
KW  - H SI6.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mortality; chemical industry; cancer; occupational health
ER  - 



TY  - JOUR
T1  - Effects of a cotton bract extract on guinea pig isolated airway smooth muscle.
AN  - 14413862; 1314194
AB  - The effects of a water extract of cotton bracts (CBE) on guinea pig isolated trachealis smooth muscle was studied. The ability of CBE to evoke tension responses, to modify tissue reactivity to excitatory and inhibitory agents, and to modify electric field stimulation-induced neurogenic responses was evaluated. CBE caused contraction in low concentrations, which were not mediated by histamine H sub(1)-, muscarinic, or 5-hydroxytryptamine (5-HT) receptors, and caused relaxation in high concentrations. In the presence of CBE, the maximum contractile response to 5-HT and the sensitivity to KCl were reduced. The maximum relaxation responses and sensitivities to adenosine and ATP were increased by CBE. In contrast, contractile responses to histamine and methacholine and relaxation responses to isoproterenol were unaffected. Neurogenic cholinergic excitatory responses and neurogenic adrenergic responses did not appear to be affected by CBE. However, the relaxant effect of nonadrenergic inhibitory nerve stimulation was increased in the presence of CBE.
JF  - Journal of Toxicology and Environmental Health
AU  - Fedan, J S
AU  - Franczak
AU  - Cahill, J F
AU  - Kosten, C J
AU  - Morey, PR
AU  - Weber, K C
AD  - Physiol. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 189
EP  - 204
VL  - 18
IS  - 2
SN  - 0093-4108, 0093-4108
KW  - extracts
KW  - effects on
KW  - guinea-pigs
KW  - trachea
KW  - guinea pigs
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - cotton
KW  - inhalation
KW  - neurotoxicity
KW  - muscles
KW  - X 24151:Acute exposure
KW  - H SM9.31:INHALATION INJURIES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cotton; muscles; neurotoxicity; inhalation; trachea
ER  - 



TY  - CONF
T1  - An overview of species differences in the effects of a water extract of cotton bract on isolated airway smooth muscle, and effects of E. coli lipopolysaccharide.
AN  - 14406881; 1254870
AB  - The authors' laboratory has been comparing the activity of a water extract of cotton bract (CBE) with the isolated trachealis smooth muscle of the dog, guinea pig, and cat. CBE induced contractions that were not mediated by 5-hydroxytryptamine (5-HT), histamine, or muscarinic receptors. The active agent(s) in CBE was dialyzable (< 14,000 molecular weight), and substantial activity was retained after low-temperature ashing. CBE potentiated contractions of dog trachealis to histamine and 5-HT and relaxation responses to isoproterenol, whereas it had no effect on responses to methacholine and KCl. In the guinea pig trachealis, CBE reduced responsiveness to KCl, potentiated relaxations to adenosine and ATP, and did not alter the responses to the remaining agents. Responses of cat trachealis to KCl and isoproterenol were potentiated by CBE, while those to 5-HT were unaffected. Neurogenic cholinergic contractile responses were potentiated by CBE in the trachealis of the dog, but not of the guinea pig, while neurogenic relaxations were potentiated by CBE in guinea pig trachealis but not in the dog trachealis.
JF  - Environmental Health Perspectives
AU  - Fedan, J S
AU  - Robinson, V A
AU  - Hay, DWP
AU  - Weber, K C
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 159
EP  - 165
VL  - 66
KW  - extracts
KW  - effects on
KW  - in vitro
KW  - trachea
KW  - dogs
KW  - guinea-pigs
KW  - cats
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - cotton
KW  - animals
KW  - toxicity
KW  - muscles
KW  - dust
KW  - X 24151:Acute exposure
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Performance of asbestos fiber counting laboratories in the NIOSH Proficiency Analytical Testing (PAT) program.
AN  - 14406668; 1315376
AB  - Asbestos fiber counting data reported in the NIOSH Proficiency Analytical Testing (PAT) Program are used in this study to evaluate the analytical performance of participating laboratories and to determine if overall performance has improved during a ten-year period. PAT laboratories have achieved intralaboratory precision of 0.18 to 0.28 relative standard deviation (RSD), and interlaboratory precision of 0.33 to 0.44 RSD. In addition, there was higher variability between PAT laboratories from 1974 to 1978, when the program underwent considerable change and growth than the variability found during previous or subsequent time periods. The improvement in interlaboratory precision by approximately one-third since 1974 and the tendency of laboratories with little PAT experience to have poorer interlaboratory precision than more experienced laboratories raises a concern that interlaboratory precision may deteriorate as large numbers of new laboratories start to enroll in the PAT program with the increased emphasis on asbestos removal in public buildings.
JF  - American Industrial Hygiene Association Journal
AU  - Schlecht, P C
AU  - Shulman, SA
AD  - NIOSH, Div. Phys. Sci. and Eng., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 259
EP  - 269
VL  - 47
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts
KW  - fibers
KW  - asbestos
KW  - buildings
KW  - statistical analysis
KW  - laboratory testing
KW  - H SI1.21:HOUSING AND BUILDING INDUSTRIES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14406668?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Performance+of+asbestos+fiber+counting+laboratories+in+the+NIOSH+Proficiency+Analytical+Testing+%28PAT%29+program.&rft.au=Schlecht%2C+P+C%3BShulman%2C+SA&rft.aulast=Schlecht&rft.aufirst=P&rft.date=1986-01-01&rft.volume=47&rft.issue=5&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - asbestos; fibers; statistical analysis; buildings; laboratory testing
ER  - 



TY  - JOUR
T1  - Evaluation of the DuPont Pro-Tek) formaldehyde badge and the 3M formaldehyde monitor.
AN  - 14406084; 1255584
AB  - The 3M Formaldehyde Monitor and the DuPont Pro-Tek) Formaldehyde Badge were evaluated for performance and reliability. This evaluation revealed that the 3M monitor results were variable and lower than reference concentrations determined independently. When the monitors were humidified before use and then exposed in humid (ca. 80% RH) formaldehyde-containing atmosphere, the monitors did give accurate results. Results of additional experiments led to the conclusion that quantitative reaction between formaldehyde generated in the authors' chamber and the absorbent pad in the 3M monitor required the presence of a minimum level of absorbed water. The DuPont badges gave good agreement with the reference concentrations determined independently under the following conditions: a) sampling period of 1 to 12 hr with a minimum integrated sample loading of 4 ppm-hr; b) at least 3 m/min (10 ft/min) face velocity; c) correction for blank badges; and d) correction for loss of reagent from the samples. The evaluation indicated that the DuPont badge was not well suited to short term samplingand was subject to evaporation of liquid from the absorbing liquid blister.
JF  - American Industrial Hygiene Association Journal
AU  - Kennedy, E R
AU  - Hull, R D
AD  - NIOSH, Div. Phys. Sci. and Eng., Methods Res. Branch, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 94
EP  - 105
VL  - 47
IS  - 2
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - atmosphere
KW  - formaldehyde
KW  - monitoring instruments
KW  - performance
KW  - occupational exposure
KW  - P 0000:AIR POLLUTION
KW  - H SI0.8.2:CHEMICALS (CORROSION)
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14406084?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Evaluation+of+the+DuPont+Pro-Tek%29+formaldehyde+badge+and+the+3M+formaldehyde+monitor.&rft.au=Kennedy%2C+E+R%3BHull%2C+R+D&rft.aulast=Kennedy&rft.aufirst=E&rft.date=1986-01-01&rft.volume=47&rft.issue=2&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - formaldehyde; atmosphere; monitoring instruments; performance; occupational exposure
ER  - 



TY  - CONF
T1  - Toxicity of mycotoxins for the rat pulmonary macrophage in vitro.
AN  - 14405217; 1254698
AB  - The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in the authors' laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macrophage activation. Similarly, patulin caused a significant release of radiolabeled chromium, decrease in ATP levels, significant inhibition of protein and RNA synthesis, and inhibition of phagocytosis. The data show that both T-2 toxin and patulin are highly toxic to rat alveolar macrophages in vitro. The data further suggest that the presence of these mycotoxins in airborne respirable dust might present a hazard to exposed workers.
JF  - Environmental Health Perspectives
AU  - Sorenson, W G
AU  - Gerberick, G F
AU  - Lewis, D M
AU  - Castranova, V
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 45
EP  - 53
VL  - 66
KW  - in vitro
KW  - effects on
KW  - rats
KW  - T-2 toxin
KW  - patulin
KW  - macrophages
KW  - grain
KW  - Pollution Abstracts; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts
KW  - lung
KW  - occupational exposure
KW  - mycotoxins
KW  - K 03086:Immunology & vaccination
KW  - X 24155:Biochemistry
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - F 06802:Fungi
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14405217?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Improved local exhaust control by directed push-pull ventilation system.
AN  - 14404982; 1315449
AB  - Experiments using the directed push-pull ventilation technique were conducted on a general type of local exhaust ventilation installation. The exhaust (pull) system consisted of a square hood, while the push system consisted of one or two slot jets or two round jets. The two slot or round jets were located behind and beside a mannequin (the mannequin simulated the worker's position). The one slot jet was located between the smoke source and the mannequin. Under experimental conditions, the push-pull system reduced the amount of smoke in the mannequin's breathing zone even when the exhaust system volume flow rate necessary for capture of the smoke decreased approximately 50%. Generally, no difference between the slot and round jet control performance was found. The experiments showed that the directed push-pull ventilation system can be used effectively to reduce the contaminant emission into a workroom, if the jets are located so that the eddy currents induced by the worker or other obstructions are minimized or eliminated.
JF  - American Industrial Hygiene Association Journal
AU  - Hampl, V
AU  - Hughes, R T
AD  - NIOSH, Div. Phys. Sci. and Eng., Robert A. Taft. Lab.., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 59
EP  - 65
VL  - 47
IS  - 1
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational health
KW  - control systems
KW  - ventilation
KW  - flow rates
KW  - exhaust emissions
KW  - smoke
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - P 0000:AIR POLLUTION
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ventilation; flow rates; smoke; exhaust emissions; control systems; occupational health
ER  - 



TY  - CONF
T1  - In vitro and in vivo changes in human complement caused by silage.
AN  - 14404674; 1254765
AB  - Aqueous extracts of silage samples from four farms in up-state New York were reacted in vitro with normal human serum. Hemolytic levels of complement component C3 were consumed in a dose-dependent fashion, and the four extracts differed in their relative activity rankings. Studies with chelated serum indicate that the alternative complement pathway is involved in the activation, and the active fragment C3b was demonstrated. Serum levels of hemolytic C3 and C4 in vivo were quantified before and after farmers performed their normal silo unloading operations. Although the study groups were small, suggestive evidence of in vivo complement consumption was found, IgE-related allergy did not appear to be of significance to the study groups. Complement activation may be an initiator of or contributor to adverse reactions in farmers who are exposed to airborne silage dusts.
JF  - Environmental Health Perspectives
AU  - Olenchock, SA
AU  - May, J J
AU  - Pratt, D S
AU  - Lewis, D M
AU  - Mull, J C
AU  - Stallones, L
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 91
EP  - 96
VL  - 66
KW  - extracts
KW  - effects on
KW  - silage
KW  - complement
KW  - man
KW  - Pollution Abstracts; Immunology Abstracts; Toxicology Abstracts
KW  - agriculture
KW  - dust
KW  - occupational exposure
KW  - X 24155:Biochemistry
KW  - P 0000:AIR POLLUTION
KW  - F 06846:Clinical
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Eliminating lead poisoning.
AN  - 14403598; 1315363
AB  - A joint NIOSH/Division of Safety and Hygiene study identified workplaces with lead problems in order to concentrate prevention services.
JF  - Ohio Monitor
AU  - Seligman, P
AD  - Div. Surveill., Hazard Eval. and Field Stud., NIOSH, Cincinnati, OH, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 14
EP  - 17
VL  - 59
IS  - 5
KW  - NIOSH
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - lead
KW  - environmental protection
KW  - occupational health
KW  - risk assessment
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14403598?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - lead; environmental protection; occupational health; risk assessment
ER  - 



TY  - JOUR
T1  - Effective controls for ethylene oxide - a case study.
AN  - 14402997; 1255624
AB  - The National Institute for Occupational Safety and Health (NIOSH) has studied the control of ethylene oxide (EtO) exposure associated with hospital sterilizers to determine which combinations of control measures are most effective. This case study describes the evaluation of controls at one hospital. The hospital had a gas sterilizer which used a mixture of EtO (12 percent by weight) in Freon-12). The sterilizer was retrofitted with the manufacturer's control system consisting of a ventilated air gap, local exhaust ventilation above the sterilizer door, and cycle modifications for additional end-of-cycle air flushes. Personal and area samples for EtO were collected with charcoal tubes for laboratory analysis (NIOSH method No 1607) and in gas sampling bags for on-site analysis with a portable gas chromatograph. The area in front of the sterilizer was also monitored with an infrared analyzer. All full-shift personal exposures and area concentrations were less than 0.05 ppm.
JF  - APPL. IND. HYG.
AU  - Mortimer, V D
AU  - Kercher, S L
AU  - O'Brien, D M
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 15
EP  - 20
VL  - 1
IS  - 1
KW  - ethylene oxide
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - occupational health
KW  - hospitals
KW  - ventilation
KW  - control systems
KW  - H SM1.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; control systems; ventilation; hospitals
ER  - 



TY  - JOUR
T1  - Benefits of a nickel-cadmium battery cycler.
AN  - 14402855; 1255574
AB  - A battery cycler that could prolong the life of nickel-cadmium batteries used in personal sampling pumps was described several years ago in the industrial hygiene literature. Cycling involves disharging a battery to a predetermined voltage level, then recharging at a fixed rate for a timed interval. The cycler evaluated here was fashioned after that earlier cycler, but has an improved recharge timer. Current capacity measurements of batteries during discharge have shown that cycling can improve the capacity of older batteries. Measurements on 17 used battery packs gave the following results: 5 improved substantially, 2 improved slightly, 9 were unchanged, and 1 actually deteriorated. Measurements on newer, unused battery packs showed there is no benefit to cycling them.
JF  - APPL. IND. HYG.
AU  - Kovein, R J
AU  - Abell, M T
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 29
EP  - 33
VL  - 1
IS  - 1
KW  - batteries
KW  - monitoring measurements
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - occupational health
KW  - cadmium
KW  - nickel
KW  - H SI10.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - nickel; cadmium; occupational health
ER  - 



TY  - JOUR
T1  - Evaluation of building ventilation systems.
AN  - 14402829; 1255569
AB  - Over the past several years, NIOSH has responded to health hazard evaluation requests from workers in dozens of office environments. Typically, the employees have complained of headache, eye and upper respiratory tract irritation, dizziness, lethargy and the inability to concentrate. Most often "inadequate ventilation" has been blamed for these complaints. Of paramount importance in the evaluation and correction of these problems is an effective evaluation of the building's ventilation system. Heating, ventilating and air-conditioning conditions that can cause worker stresses include: migration of odors or chemical hazards between building areas; reentrainment of exhaust from building fume hoods or through heat wheels; buildup of microorganisms in the HVAC system components; and poor odor or environmental control due to insufficient "fresh" outdoor air or system heating or cooling malfunction. The purpose of this paper is to provide an overview of building ventilation systems, the ventilation problems associated with poorly designed or operating systems, and the methodology for effectively evaluating system performance.
JF  - American Industrial Hygiene Association Journal
AU  - Hughes, R T
AU  - O'Brien, D M
AD  - NIOSH, 2676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 207
EP  - 213
VL  - 47
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - odors
KW  - occupational health
KW  - ventilation
KW  - heating systems
KW  - buildings
KW  - cooling systems
KW  - P 0000:AIR POLLUTION
KW  - H SI1.11:SAFETY ENGINEERING
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ventilation; buildings; odors; cooling systems; heating systems; occupational health
ER  - 



TY  - JOUR
T1  - Permeation of chemical protective clothing by three binary solvent mixtures.
AN  - 14399010; 1255435
AB  - An evaluation of glove materials against three different binary chemical mixtures selected from common industrial solvents was conducted. Changes in breakthrough time and permeation rate of the mixture components were evaluated as a function of the mixture composition. An increase in employee risk resulting from early mixture breakthrough time and enhanced mixture permeation rate over that of the pure chemicals was demonstrated. The permeation of a binary mixture through chemical protective clothing could not be predicted by the permeation resuts of the pure components. It is recommended that chemical protective clothing be tested for its permeation characteristics with the use of the chemical mixtures and conditions that reflect the work site exposure.
JF  - American Industrial Hygiene Association Journal
AU  - Mickelsen, R L
AU  - Roder, M M
AU  - Berardinelli, S P
AD  - Div. Saf. Res., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 236
EP  - 240
VL  - 47
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - occupational safety
KW  - materials testing
KW  - solvents
KW  - textile industry
KW  - chemical treatment
KW  - H SI6.24:TEXTILE INDUSTRIES
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - solvents; materials testing; chemical treatment; textile industry; occupational safety
ER  - 



TY  - CONF
T1  - Composition of extracts of airborne grain dusts: Lectins and lymphocyte mitogens.
AN  - 14395720; 1254809
AB  - Airborne grain dusts are heterogeneous materials that can elicit acute and chronic respiratory pathophysiology in exposed workers. Previous characterizations of the dusts include the identification of viable microbial contaminants, mycotoxins, and endotoxins. The authors provide information of the lectin-like activity of grain dust extracts and its possible biological relationship. Hemagglutination of erythrocytes and immunochemical modulation by antibody to specific lectins showed the presence of these substances in extracts of airborne dusts from barley, corn, and rye. Proliferation of normal rat splenic lymphocytes in vitro provided evidence for direct biological effects on the cells of the immune system. These data expand the knowledge of the composition of grain dusts (extracts), and suggest possible mechanisms that may contribute to respiratory disease in grain workers.
JF  - Environmental Health Perspectives
AU  - Olenchock, SA
AU  - Lewis, D M
AU  - Mull, J C
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 119
EP  - 123
VL  - 66
KW  - effects on
KW  - immune system
KW  - lectins
KW  - mitogens
KW  - grain
KW  - airborne particulates
KW  - rats
KW  - particulates
KW  - Pollution Abstracts; Immunology Abstracts; Toxicology Abstracts
KW  - lymphocytes
KW  - immunology
KW  - dust
KW  - X 24155:Biochemistry
KW  - P 0000:AIR POLLUTION
KW  - F 06845:Allergens
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14395720?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Parameters that bias the measurement of airborne concentration within a respirator.
AN  - 14394045; 1255241
AB  - This paper describes the theoretical basic upon which a test system has been set up to evaluate the sampling error associated with in-facepiece sampling on half-mask respirators. The in-facepiece sampling technique evaluated in this study is the one currently used in the U.S. to conduct quantitative facepiece fit testing. An experimental design was developed to study the sampling bias associated with in-facepiece sampling when selected parameters of the man/respirator system were varied. The results indicated that significant errors can be made in estimating concentration within a respirator when the current in-facepiece sampling technique is employed. Sampling bias was determined when in-facepiece samples were collected only during the inhalation phase of the respiratory cycles. They were found to range from greater than -99% to greater than +98%. The mean sampling bias was -17 plus or minus 38%. When measured in-facepiece concentrations were used to calculate a fit factor the resulting range was 44 to 4728 even though the actual fit factor was only 87. Based upon the data presented, it was hypothesized that faceseal leakage was streamlining within the respirator cavity. As a result, quantitative facepiece fit data on half-mask respirators may be biased by the large measurement error.
JF  - American Industrial Hygiene Association Journal
AU  - Myers, W R
AU  - Allender, J
AU  - Plummer, R
AU  - Stobbe, T
AD  - DHHS, NIOSH, Div. Saf. Res., Injury Prev. Res. Branch, Morgantown, WV, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 106
EP  - 114
VL  - 47
IS  - 2
SN  - 0002-8894, 0002-8894
KW  - monitoring measurements
KW  - Pollution Abstracts
KW  - pollution control equipment
KW  - contaminants
KW  - air sampling
KW  - respirators
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14394045?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - air sampling; contaminants; respirators; pollution control equipment
ER  - 



TY  - CONF
T1  - Prevalence of IgE antibodies to grain and grain dust in grain elevator workers.
AN  - 14383429; 1254842
AB  - IgE-mediated allergic reactions have been postulated to contribute to respiratory reactions seen in workers exposed to grain dusts. In an attempt better to define the prevalence of IgE antibodies in workers exposed to grain dusts, we performed the radioallergosorbent test (RAST) on worker sera using both commercial allergens prepared from grain and worksite allergens prepared from grain dust samples collected at the worksite. The authors found that the two types of reagents identified different populations with respect to the specificity of IgE antibodies present. The RAST assay performed using worksite allergens correlated well with skin test procedures. These results may allow us to gain better understanding of allergy associated with grain dust exposure, and document the utility of the RAST assay in assessment of occupational allergies.
JF  - Environmental Health Perspectives
AU  - Lewis, D M
AU  - Romeo, P A
AU  - Olenchock, SA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 149
EP  - 153
VL  - 66
KW  - antibodies
KW  - grain
KW  - man
KW  - hypersensitivity (immediate)
KW  - Pollution Abstracts; Immunology Abstracts; Toxicology Abstracts
KW  - toxicity
KW  - dust
KW  - occupational exposure
KW  - X 24155:Biochemistry
KW  - P 0000:AIR POLLUTION
KW  - F 06846:Clinical
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Subchronic inhalation of diethylamine vapor in Fischer-344 rats: Organ system toxicity.
AN  - 14371473; 1201509
AB  - Male and female Fischer 344 (F-344) rats were exposed at 0, 25, or 250 ppm diethylamine (DEA) vapor, 6.5 hr per day, 5 days per week, for 24 weeks in order to assess cardiac and other organ system toxicity. During the first 2 weeks of exposure, the rats exposed at 250 ppm DEA did not gain weight. After 2 weeks, however, the rate of weight gain of these rats was greater than that of controls. Sneezing, tearing, and reddened noses were seen in rats exposed at 250 ppm DEA. Histopathologic examinations revealed lesions of the nasal mucosa of rats exposed at 250 ppm DEA (rats exposed at 25 ppm were not evaluated).
JF  - Fundamental and Applied Toxicology
AU  - Lynch, D W
AU  - Moorman, W J
AU  - Stober, P
AU  - Lewis, T R
AU  - Iverson, W O
AD  - NIOSH C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 559
EP  - 565
VL  - 6
IS  - 3
SN  - 0272-0590, 0272-0590
KW  - inhalation
KW  - chronic exposure
KW  - effects on
KW  - diethylamine
KW  - rats
KW  - Toxicology Abstracts
KW  - organs
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - organs
ER  - 



TY  - JOUR
T1  - Mortality of radiologists and pathologists in the radiation registry of physicians.
AN  - 14348061; 1165894
AB  - The overall and cause-specific mortality experience of male radiologists and a comparable group of medical specialists, pathologists, who were included in the Radiation Registry of Physicians, is presented. The study population consists of an early-entry cohort of physicians who were members of either the American College of Radiology or the College of American Pathologists as of Jan 1, 1962, and a late-entry cohort of similar members who joined these societies between January 1962, and June 1972. The purpose of the study was to determine if occupational exposure to low levels of ionizing radiation resulted in excess mortality from all causes and specific causes, or decreased survival patterns for radiologists compared with pathologists over the 16-year period, 1962 to 1977. The data revealed that radiologists and pathologists were comparable regarding overall mortality experience for all entrants, the early-entry cohort, and the late-entry cohort.
JF  - J. OCCUP. MED.
AU  - Logue, J N
AU  - Barrick, M K
AU  - Jessup, GL Jr
AD  - DHHS, FDA, Cent. Dev. and Radiol. Health (HFZ-116), Rockville, MD 20857, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 91
EP  - 99
VL  - 28
IS  - 2
SN  - 0096-1736, 0096-1736
KW  - occupational medicine
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - pathology
KW  - radiology
KW  - mortality
KW  - P 8000:RADIATION
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SM7.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mortality; radiology; pathology
ER  - 



TY  - JOUR
T1  - Computerized estimates of potential occupational health risk due to chemical exposure.
AN  - 14345668; 1166794
AB  - Estimating the potential health risk encountered by workers due to their exposure to various chemicals is enormously complex, since many chemicals be involved and each may have multiple toxic effects. As an aid to this estimation process, a computer program, or model, which computer index numbers expressing the relative health risk of occupational groups due to their potential chemical exposures was developed at the National Institute for Occupational Safety and Health (NIOSH). This model considers an inventory of the chemicals to which specific occupational groups are potentially exposed, the published information regarding the toxic effects of each chemical, and the conditions of occupational exposure. The system then develops indices of potential occupational group health risk by considering weighted combinations of eight distinct health effects. No direct comparison with external occupational risk indices is currently possible, but internal testing of the model reveals no obvious inconsistencies.
JF  - Risk Analysis
AU  - Pedersen, D H
AU  - Hornung, R W
AD  - NIOSH, Robert A. Taft Lab., Mail Stop R-19, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 3
EP  - 13
VL  - 6
IS  - 1
SN  - 0272-4332, 0272-4332
KW  - risk factors
KW  - chemical pollutants
KW  - occupational safety
KW  - chemicals
KW  - computer programs
KW  - mathematical models
KW  - occupational exposure
KW  - risk assessment
KW  - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - H SI0.8.2:CHEMICALS (CORROSION)
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - risk assessment; occupational exposure; mathematical models; computer programs; occupational safety; chemicals
ER  - 



TY  - JOUR
T1  - Interaction between tobacco smoking and occupational exposures in the causation of lung cancer.
AN  - 14316616; 1143032
AB  - The nature of the interaction between smoking and occupational exposure is controversial, in part because of lack of agreement on the definition of interaction and in part because of the scarcity of adequate epidemiologic data. Occupational investigators have assessed interaction primarily as a departure from an additive rather than from a multiplicative model of relative risks. To determine whether smoking modifies the effect of occupational lung carcinogens, the literature was reviewed for the only four estibalished occupational lung carcinogens for which there are data on smoking: radon daughters, asbestos, arsenic, and chloromethyl ethers. Where possible, departure was assessed from both an additive and a multiplicative model. Only nine studies were considered to have sufficient sample size and to provide sufficient information on tobacco use and occupational exposure to evaluate interaction.
JF  - J. OCCUP. MED.
AU  - Steenland, K
AU  - Thun, M
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 110
EP  - 118
VL  - 28
IS  - 2
SN  - 0096-1736, 0096-1736
KW  - chronic exposure
KW  - interaction
KW  - man
KW  - cigarette smoke
KW  - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - carcinogens
KW  - carcinogenesis
KW  - occupational exposure
KW  - cigarettes
KW  - lung
KW  - risk assessment
KW  - cancer
KW  - H SE4.26:DRUGS AND ALCOHOL
KW  - X 24180:Social poisons & drug abuse
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - lung; cancer; occupational exposure; cigarettes; risk assessment; carcinogens; carcinogenesis; cigarette smoke
ER  - 



TY  - JOUR
T1  - Tissue distribution of 2,3,7,8-TCDD in bullfrogs obtained from a 2,3,7,8-TCDD-contaminated area
AN  - 13816499; 198602775
AB  - Two male and four female adult bullfrogs (Rana catesbeiana) were collected from Rockey Branch creek which flowed through a 2,3,7,8-TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) contaminated industrial site. Analysis of fat (sampled only in 1 male and 1 female), leg muscle, liver, oviduct and ovaries showed TCDD concentrations to be highest in fat (68,000 ppt) and lowest in muscle (mean 87-637 ppt). Data also indicated that female frogs stored a significant amount of their TCDD body burden in their ovaries and oviducts.
JF  - Chemosphere
AU  - Korfmacher, WA
AU  - Hansen, E B
AU  - Rowland, K L
AD  - National Center for Toxicological Research, Jefferson, Ark.
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 121
EP  - 126
VL  - 15
IS  - 2
SN  - 0045-6535, 0045-6535
KW  - Tetrachlorodibenzo-p-dioxin
KW  - Aqualine Abstracts
KW  - AQ 00008:Effects of Pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Use of bullfrogs (Rana catesbeiana) as biological markers for 2,3,7,8-tetrachlorodibenzo-p-dioxin contamination in the environment
AN  - 13806334; 198702494
AB  - Rockey Branch creek in central Arkansas was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), originating from a former industrial site. The livers of 10 adult bullfrogs, collected from the creek in 1984 and 1985, contained between 0.64 and 48.0 ppb TCDD. These findings, along with the fact that bullfrogs were fairly easy to catch, more abundant than fish in some areas, and appeared to have a high tolerance to TCDD, suggested that R. catesbeiana might be a useful biological indicator of the extent of 2,3,7,8-TCDD contamination in a given aquatic area.
JF  - Science of the Total Environment
AU  - Korfmacher, WA
AU  - Hansen, E B
AU  - Rowland, K L
AD  - National Center for Toxicological Research, Jefferson, Ark.
Y1  - 1986
PY  - 1986
DA  - 1986
SP  - 257
EP  - 262
VL  - 57
SN  - 0048-9697, 0048-9697
KW  - Fish (see also individual groups listed below)
KW  - Tetrachlorodibenzo-p-dioxin
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Festival of the Sun
AN  - 1293256454
JF  - Soviet Literature
AU  - Barda, Fricis
Y1  - 1986/01/01/
PY  - 1986
DA  - 1986 Jan 01
SP  - 156
CY  - Moscow
PB  - Lepta
VL  - 0
IS  - 8
SN  - 0202-1870
KW  - Literature
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DB  - Periodicals Index Online
N1  - Last updated - 2013-03-21
ER  - 



TY  - JOUR
T1  - Respiratory disease and suicide among U.S. coal miners: is there a relationship?
AN  - 76663613; 3870926
AB  - A case-control study was performed to test whether or not respiratory disease in coal miners presented a risk for suicide. While coal miners in general do not experience elevated rates of suicide, coal miners with respiratory disease have been found to have high rates of psychiatric disability, especially depressive reactions. Further, depression has been related to suicide. To test the hypothesis, 50 suicide deaths from four National Institute for Occupational Safety and Health cohorts of coal miners were matched by age at death to two series of controls, a noncancer, nonaccident control series, and a cancer control series. Using odds ratios (tested by chi-square) the risks of obstructive lung disease and coal workers pneumoconiosis were evaluated together with the risks of years of underground mining, cigarette smoking at the time of cohort creation, and ever having smoked cigarettes. Neither respiratory disease was found to pose a statistically elevated risk of suicide in this sample of U.S. white male coal miners.
JF  - American journal of preventive medicine
AU  - Ames, R G
AD  - National Institute for Occupational Safety and Health, Morgantown.
PY  - 1985
SP  - 58
EP  - 60
VL  - 1
IS  - 6
SN  - 0749-3797, 0749-3797
KW  - Index Medicus
KW  - United States
KW  - Risk Factors
KW  - Humans
KW  - Adult
KW  - Smoking -- epidemiology
KW  - Male
KW  - Pneumoconiosis -- complications
KW  - Coal Mining
KW  - Pneumoconiosis -- psychology
KW  - Suicide -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1988-06-29
N1  - Date created - 1988-06-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-17
ER  - 



TY  - JOUR
T1  - Privacy Act of 1974; revision of system of records.
AN  - 75933023; 11645562
JF  - Federal register
AU  - U.S.  Public Health Service
AD  - U.S.  Public Health Service
Y1  - 1985/09/06/
PY  - 1985
DA  - 1985 Sep 06
SP  - 36491
EP  - 36494
VL  - 50
IS  - 173
SN  - 0097-6326, 0097-6326
KW  - Bioethics
KW  - Privacy Act 1974
KW  - Biomedical and Behavioral Research
KW  - Mental Health Therapies
KW  - National Institute on Drug Abuse
KW  - Legal Approach
KW  - Professional Patient Relationship
KW  - Humans
KW  - Reference Standards
KW  - Adult
KW  - Research
KW  - Public Policy
KW  - Behavioral Research
KW  - Adolescent
KW  - Legislation as Topic
KW  - Medical Records
KW  - Government Regulation
KW  - Government
KW  - Social Control, Formal
KW  - Confidentiality
KW  - Substance-Related Disorders
KW  - Records as Topic
KW  - Privacy
KW  - Human Experimentation
KW  - Databases, Factual
KW  - Federal Government
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 1986-03-27
N1  - Date created - 1986-03-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - RPRT
T1  - Location Patterns of Minority and Other Health Professionals.
AN  - 63321184; ED265051
AB  - Descriptions of the number and distributions of minority physicians, dentists, and pharmacists within certain geographically and demographically defined areas are provided. Data from the Bureau of the Census for the 1980 Decennial Census were used in examining distribution patterns of minority and non-minority practitioners by geographic region, number of inhabitants, poverty status of the area, and primary care manpower shortage area designation status. Where possible, practitioner-to-population ratios by race/ethnicity are also presented for localities. This study's findings indicate: (1) Asians outnumbered other minority groups, especially within the physician supply; (2) uneven distribution patterns occurred among geographic regions of the country regardless of race/ethnicity; (3) all racial/ethnic professionals were disproportionally located in heavily populated areas, but minority health professionals were more likely than white health professionals to reside in the most populous counties; and (4) an overwhelming majority of all health professionals resided in counties which were not classified as high poverty areas. Numerous tables are contained throughout the text and in the appendix. (ML)
AU  - Spratley, Ernell
AU  - Drabek, John
Y1  - 1985/08//
PY  - 1985
DA  - August 1985
SP  - 88
VL  - DHHS-HRS-P-OD 85-2; HRP-0906479
KW  - ERIC, Resources in Education (RIE)
KW  - Ethnic Distribution
KW  - Minority Groups
KW  - Racial Distribution
KW  - Geographic Distribution
KW  - Dentists
KW  - Physicians
KW  - Employment Patterns
KW  - Pharmacists
KW  - Census Figures
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LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Black & Minority Health. Report of the Secretary's Task Force. Volume 1: Executive Summary.
AN  - 63312336; ED263293
AB  - This volume presents major findings and recommendations of the Department of Health and Human Service's (DHHS) Task Force on Black and Minority Health. The recommendations, which are based on data collected from a number of sources, are intended to guide DHHS in developing programs and policies that address the continuing disparity in the burden of death and illness experienced by Blacks and other minority Americans as compared to the national population as a whole. The report is divided into three major sections. The first presents a general introduction and overview of Task Force activities. The second section provides the recommendations, organized into six categories: (1) health information and education; (2) delivering the financing health services; (3) health professions' development; (4) cooperative efforts with the non-Federal sector; (5) data development; and (6) research agenda. The third section presents findings which account for the health status disparity. This section is organized under these sub-headings: (1) social characteristics of minority populations; (2) mortality and morbidity indicators; (3) summary reports of the task force subcommittees (which studied cancer; cardiovascular and cerebrovascular diseases; chemical dependency; diabetes; homicide, suicide, and unintentional injuries; and infant mortality and low birthweight); (4) health services and resources for minorities; (5) inventory of DHHS program efforts; and (6) survey of non-Federal organizations. Appendices are included, which list the members of the task force and its subcommittees, task force staff, and commissioned papers. (KH)
Y1  - 1985/08//
PY  - 1985
DA  - August 1985
SP  - 245
KW  - Department of Health and Human Services
KW  - Health Status
KW  - ERIC, Resources in Education (RIE)
KW  - Death
KW  - Drug Addiction
KW  - Blacks
KW  - Socioeconomic Status
KW  - Government Role
KW  - Suicide
KW  - Infant Mortality
KW  - Health Education
KW  - Cancer
KW  - American Indians
KW  - Diabetes
KW  - Health Services
KW  - Health Needs
KW  - Cultural Traits
KW  - Minority Groups
KW  - Research Needs
KW  - Hispanic Americans
KW  - Heart Disorders
KW  - Alcoholism
KW  - Asian Americans
KW  - Diseases
KW  - Information Needs
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63312336?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519944237
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 1
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944188
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944141
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Investigating the Role of Substance Abuse in Occupational Injuries
AN  - 1474329485
AB  - Alcohol and drugs in the workplace: An occupational hazard
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 42
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Drug Use in Aviation
AN  - 1474324567
AB  - Substance abuse clouds pilot performance
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 34
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol, Other Drugs, and Traffic Safety
AN  - 1474323774
AB  - Drinking and drugged drivers - for whom the highway tolls
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 16
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Next Issue
AN  - 1474323744
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 72
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - SOS: Alcohol, Drugs and Boating
AN  - 1474302159
AB  - Bourbon and water don't mix
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Stopping Substance Abuse in its Tracks: Alcohol and Drugs on the Railroad
AN  - 1474302032
AB  - Highballing at work
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 46
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin 7
AN  - 1474301737
AB  - The Enigma of Chronic Liver Disease and Cirrhosis as Alcohol-Related Diagnoses
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 56
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - A New Initiative for Solving Age-Old Problems
AN  - 1474301344
AB  - NIAAA and NIDA join forces on Alcohol-and Drug-Related Safety and Performance Issues
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Adverse Effects of Alcohol and Other Drugs on Human Performance
AN  - 1474301296
AB  - Researchers study how alcohol and drug impairments impact on complex skills
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 11
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin 8
AN  - 1474301252
AB  - Trends in Alcohol-Related Fatal Motor Vehicle Accidents for 1983
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 60
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Not-So-Safe Refuge: Unintentional Injuries in the Home and at Play
AN  - 1474301113
AB  - The home can be as dangerous as the highways
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 24
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Epidemiology of Injury
AN  - 1474301084
AB  - Scientists show that accidents are not "chance" events
JF  - Alcohol Health and Research World
Y1  - 1985///Summer
PY  - 1985
DA  - Summer 1985
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 4
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Stuttering Indians: a reply to Zimmermann et al.
AN  - 85163744; pmid-4010263
JF  - Journal of Speech and Hearing Research
AU  - Stewart, J L
AD  - Sensory Disabilities Program, Indian Health Service-Headquarters West, Albuquerque, New Mexico.
PY  - 1985
SP  - 313
EP  - 316
VL  - 28
IS  - 2
SN  - 0022-4685, 0022-4685
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LA  - English
DB  - ComDisDome
N1  - Last updated - 2010-05-07
ER  - 



TY  - RPRT
T1  - Women's Health. Report of the Public Health Service Task Force on Women's Health Issues. Volume II.
AN  - 63217330; ED283797
AB  - This report identifies a broad spectrum of issues affecting women's health and is divided into four sections: (1) social factors affecting women's health; (2) women's physical health and well-being; (3) health concerns of older women; and (4) issues related to alcohol, drug use and abuse, and the mental health of women. The Public Health Service Task Force responsible for the report identified critical issues through the work of ten regional meetings that provided perspectives from state, local, community, and provider representatives. Findings from these meetings are discussed and suggestions for action, a summary, a conclusion, and references are offered. Papers commissioned for the report by the Task Force are included and deal with the following issues: (1) "Alcohol and Maternal and Fetal Health" (Kenneth Warren); (2) "Arranging for Child Care: Implications for the Well-Being of Employed Mothers and Their Children" (Martha Zaslow, and others); (3) "Cancer in Women" (Harriet Page); (4) Guidelines for Avoiding Methodological and Policy-Making Biases in Gender-Related Health Research" (Jean A. Hamilton); (5) "Heart Disease in Women" (Barbara Packard); (6) "Immunizations of Special Importance to Women" (Ida M. Onorato); (7) "Nutritional Issues in Women" (Artemis P. Simopoulos); (8) "Osteoporosis" (Lawrence E. Shulman); (9) "Premenstrual Syndrome" (Miriam Davis); (10) "Smoking and Women's Health" (Thomas J. Glynn and Joseph W. Cullen); (11) "Systemic Lupus Erythematosus" (Lawrence E. Shulman); and (12) "Special Health Concerns of Ethnic Minority Women" (Audrey Manley, and others). (JD)
Y1  - 1985/05//
PY  - 1985
DA  - May 1985
SP  - 352
KW  - ERIC, Resources in Education (RIE)
KW  - Social Influences
KW  - Physical Fitness
KW  - Mental Health
KW  - Violence
KW  - Nutrition
KW  - Economic Factors
KW  - Older Adults
KW  - Minority Groups
KW  - Preventive Medicine
KW  - Females
KW  - Drug Use
KW  - Physical Health
KW  - Drug Abuse
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63217330?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519945098
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 3
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944216
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 1
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - From behavior to molecules
AN  - 1474329858
JF  - Alcohol Health and Research World
AU  - George, Frank
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - DWI Update
AN  - 1474329267
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 55
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Special Populations
AN  - 1474329261
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 13
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Newsnotes
AN  - 1474328722
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 50
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474328722?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - An Interview with Boris Tabakoff, Ph.D.
AN  - 1474327240
AB  - A discussion of NIAAA's Intramural Research Program
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 25
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474327240?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The National Alcohol Research Centers
AN  - 1474326740
AB  - Research from a variety of disciplinary and interdisciplinary perspectives
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Does alcohol actually reduce stress?
AN  - 1474326739
JF  - Alcohol Health and Research World
AU  - Sher, Kenneth
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 30
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474326739?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Prevention Research
AN  - 1474325323
AB  - The exciting science of preventing problems
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 18
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Determining Alcohol Concentration
AN  - 1474323875
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 17
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474323875?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Laboratory for Clinical Studies
AN  - 1474323797
AB  - Where clinical and experimental come together
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 22
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research and Research Dissemination: An Interview with Robert G. Niven, M.D.
AN  - 1474323606
AB  - The Director of NIAAA talks about research and future directions
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Applying for a Research Grant
AN  - 1474303357
AB  - How, when, and where
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 34
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474302570
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 52
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Changing the minimum drinking age
AN  - 1474302356
JF  - Alcohol Health and Research World
AU  - Hughes, Stella
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 32
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - ADM Research: An Editorial by Donald Ian Macdonald, M.D.
AN  - 1474302172
AB  - The Administrator describes ADAMHA's "highest and most vital priority"
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 5
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474302172?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Animal Models
AN  - 1474302044
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 10
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol Research Dissemination by Robert W. Denniston
AN  - 1474301619
AB  - Getting out the word
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 46
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Retirement and Alcohol Problems
AN  - 1474301177
JF  - Alcohol Health and Research World
Y1  - 1985///Spring
PY  - 1985
DA  - Spring 1985
SP  - 15
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 9
IS  - 3
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - RPRT
T1  - Behavioral effects of microwave radiation absorption.
AN  - 14544923; 1427340
AB  - The need for an understanding of the biological effects induced by exposure to microwave radiation has increased in recent years because of increased usage and applications and also concerns about potential adverse health effects. Although many research studies have been conducted to examine the question of biological effects, the information is scattered in many diverse sources. This publication brings together in a single source the major research findings related to the behavioral consequences of microwave exposure. In addition it attempts to provide a critical assessment of this information and to provide a perspective upon which the reader can interpret the findings. This publication begins with a review of behavioral-microwave research in the Soviet Union and then proceeds to examine the work of researchers in the Western countries. Both learned and unlearned behaviors are examined in the context of microwave induced effects. Other important areas which are covered include: selecting appropriate animal models, extrapolation of animal data to humans, dose considerations, and problems inherent in this type of research.
JF  - NTIS, SPRINGFIELD, VA (USA). 1985.
AU  - Monahan, J C
AU  - D'Andrea, JA
Y1  - 1985/04//
PY  - 1985
DA  - Apr 1985
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - microwaves
KW  - dose response effects
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - radiation
KW  - human factors
KW  - absorption
KW  - P 8000:RADIATION
KW  - H SM7.7:HUMAN FACTORS
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14544923?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Monahan%2C+J+C%3BD%27Andrea%2C+JA&rft.aulast=Monahan&rft.aufirst=J&rft.date=1985-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Behavioral+effects+of+microwave+radiation+absorption.&rft.title=Behavioral+effects+of+microwave+radiation+absorption.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-113735/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Dioxin registry report: Walk-through survey of Pentachlorophenol Production Facility at Vulcan Materials Company, Chemical Division, Wichita, Kansas.
AN  - 14494196; 1410944
AB  - A walkthrough survey of the pentachlorophenol (87865) (PCP) production facility at Vulcan Materials Company (SIC-2865), Wichita, Kansas, August 1983 was conducted. The purpose of the survey was to determine if the PCP workers should be included in the Dioxin Registry. Breathing zone and environmental samples were analyzed for PCP, polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). All PCP concentrations were below to OSHA standard of 0.5 milligram per cubic meter. Breathing zone PCDDs concentrations ranged from less tha 0.008 to 1,067 nanograms per cubic meter. Bulk samples contained up to 893 micrograms per gram (microg/g) PCDDs and up to 12.7 microg/g PCDFs. The personnel department maintained files for all current and approximately 1,800 terminated employees. Medical files existed for terminated employees back to 1976.
JF  - NTIS, SPRINGFIELD, VA (USA). 1985.
AU  - Marlow, D
AU  - Fingerhut, M
Y1  - 1985/04//
PY  - 1985
DA  - Apr 1985
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - pentachlorophenol
KW  - dioxin
KW  - Pollution Abstracts
KW  - environmental monitoring
KW  - surveys
KW  - occupational health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-191988/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Health hazard evaluation report HETA 84-368-1624, FMC Corporation, San Jose, California.
AN  - 14493497; 1410927
AB  - Environmental and breathing zone samples were analyzed for metals, total dust, asbestos (1332214), organic solvents, methylene-bisphenyl-diisocyanate (101688), and cutting and cooling oils at the FMC Corporation (SIC-9999) in San Jose, California in July, September, and December, 1984. The evaluation was requested by a union representative because of concern about an increasing number of occupationally related cases of cancer and other illnesses. Noise monitoring was also performed. Twenty two workers were interviewed. Benzene concentrations ranged from nondetectable to 0.93 part per million in the vehicle assembly area. NOISH recommends the lowest feasible limit for benzene. Asbestos sampling results were inconclusive. Noise exposures were 82.5 to 90.7 A-weighted decibels (dBA). The OSHA standard for noise is 90dBA. All other substances were nondetectable or below their relevant standards. Employees exposed to cutting oils and machine coolants reported varying degrees of dermatitis. Symptoms of eye irritation, headache, and fatigue were reported.
JF  - NTIS, SPRINGFIELD, VA (USA). 1985.
AU  - Belanger, P L
AU  - Coye, MJ
Y1  - 1985/04//
PY  - 1985
DA  - Apr 1985
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - California, San Jose
KW  - FMC Corporation
KW  - Pollution Abstracts
KW  - asbestos
KW  - noise levels
KW  - occupational health
KW  - solvents
KW  - metals
KW  - dust
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14493497?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Belanger%2C+P+L%3BCoye%2C+MJ&rft.aulast=Belanger&rft.aufirst=P&rft.date=1985-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+hazard+evaluation+report+HETA+84-368-1624%2C+FMC+Corporation%2C+San+Jose%2C+California.&rft.title=Health+hazard+evaluation+report+HETA+84-368-1624%2C+FMC+Corporation%2C+San+Jose%2C+California.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-191269/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Health Hazard Evaluation Report HETA-85-108-1593, Carey Plastics Division, Toledo Molding and Die Corp., Carey, Ohio.
AN  - 14475370; 1385295
AB  - Environmental and breathing zone samples were analyzed for orgainc solvent vapors, formaldehyde (50000), hydrogen-sulfide (7783064), sulfur-dioxide (7446095), and carbon-monoxide (630080) at Carey Plastics (SIC-3079), Carey, Ohio in December, 1984. The survey was requested by management and the union local to investigate an outbreak of illness in the workforce. The authors conclude that the illness outbreak was due to a combination of factors, rather than to a single substance. Recommendations include not idling towing motors unnecessarily, installing local exhaust ventilation, and operating the mold at the proper temperature.
JF  - NTIS, SPRINGFIELD, VA (USA). 1985.
AU  - Moseley, CL
AU  - McConnell, R
Y1  - 1985/04//
PY  - 1985
DA  - Apr 1985
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - vapor
KW  - Health & Safety Science Abstracts
KW  - sulfur dioxide
KW  - plastics
KW  - hydrogen sulfide
KW  - formaldehyde
KW  - occupational health
KW  - carbon monoxide
KW  - environmental monitoring
KW  - solvents
KW  - surveys
KW  - H SI6.8.2:CHEMICALS (CORROSION)
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14475370?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Moseley%2C+CL%3BMcConnell%2C+R&rft.aulast=Moseley&rft.aufirst=CL&rft.date=1985-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+Hazard+Evaluation+Report+HETA-85-108-1593%2C+Carey+Plastics+Division%2C+Toledo+Molding+and+Die+Corp.%2C+Carey%2C+Ohio.&rft.title=Health+Hazard+Evaluation+Report+HETA-85-108-1593%2C+Carey+Plastics+Division%2C+Toledo+Molding+and+Die+Corp.%2C+Carey%2C+Ohio.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-132164/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Health Hazard Evaluation Report HETA-85-020-1587, Department of the Interior, San Francisco Bay National Wildlife Refuge, Newark, California.
AN  - 14474723; 1385286
AB  - Area air samples were analyzed for formaldehyde (50000) at the San Francisco Bay National Wildlife Refuge (SIC-9999), Newark, California in November and December, 1984. The evaluation was requested by the manager to investigate whether the office staff at the headquaters and visitor center were being exposed to indoor air contaminants due to outgassing from plastic furniture, wood paneling, and the synthetic carpet. Six employees were interviewed to determine if they had experienced any symptoms of formaldehyde exposure.
JF  - NTIS, SPRINGFIELD, VA (USA). 1985.
AU  - Belanger, P L
Y1  - 1985/04//
PY  - 1985
DA  - Apr 1985
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - vapor
KW  - San Francisco Bay National Wildlife Refuge
KW  - Health & Safety Science Abstracts
KW  - formaldehyde
KW  - air sampling
KW  - H SE3.20:AIR POLLUTION/AIR QUALITY
KW  - H SE1.25:NATIONAL PARKS CONSERVATION
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Belanger%2C+P+L&rft.aulast=Belanger&rft.aufirst=P&rft.date=1985-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+Hazard+Evaluation+Report+HETA-85-020-1587%2C+Department+of+the+Interior%2C+San+Francisco+Bay+National+Wildlife+Refuge%2C+Newark%2C+California.&rft.title=Health+Hazard+Evaluation+Report+HETA-85-020-1587%2C+Department+of+the+Interior%2C+San+Francisco+Bay+National+Wildlife+Refuge%2C+Newark%2C+California.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-132172/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - RPRT
T1  - Food and Drug Administration: A plan for action.
AN  - 14336508; 1173989
AB  - FDA's Plan for Action designates FDA's highest priorities and charts a broad course for the Agency's policy and management directions in the years ahead. The plan was based on extensive meetings that The Commissoner had with persons both inside and outside of government. This action plan consists of the following: (1) New Drug Review Process-specifically accelerate and improve review of human drugs; (2) Medical Devices Program-implement the 1976 Medical Device Amendment to facilitate marketing products; (3) Postmarketing Surveillance-strengthen activities to enhance protection against new and unforeseen risks with marketed products; (4) risk Assessment-evaluate, test and assess the risk to humans of compounds in the food supply causing cancer in laboratory animals; (5) Risk Management-improve risk taking process by prudent use of education, enforcement, regulation and voluntary compliance; (6) Food Safety-resolve food safety issues by administrative and legislative means.
JF  - NTIS, SPRINGFIELD, VA (USA). 1985.
Y1  - 1985/04//
PY  - 1985
DA  - Apr 1985
PB  - NTIS, SPRINGFIELD, VA (USA)
KW  - FDA
KW  - foods
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - federal programs
KW  - drugs
KW  - nutrition
KW  - risk assessment
KW  - P 9000:ENVIRONMENTAL ACTION
KW  - H SE4.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14336508?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Food+and+Drug+Administration%3A+A+plan+for+action.&rft.title=Food+and+Drug+Administration%3A+A+plan+for+action.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-107117/GAR.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Characterization of Thymidine Kinase in L5178y mOuse Lymphoma Cells
AN  - 760215807; 13623391
AB  - Thymidine kinase (TK) was isolated from four different cell lines (TK +/+ P4, TK +/- P4.3.4, TK+/- 3.7.2C, and TK -/- P4.3) that represent the genotypes of L5178 Y mouse lymphoma cells. TK isolated from each of the different cell lines was characterized with respect to the estimated isoelectric point (pI), temperature sensitivity, estimated substrate dissociation constants (Km), estimated inhibitor constant (K sub(i)), and response to the activator deoxycytidine diphosphate. The characteristics of TK from the different cell lines were compared to determine whether the product of the TK gene was changed by the mutation that produced the TK-/- genotype and reverse mutation to the TK +/- genotype. The results indicate that the TK enzymes isolated from the TK+/+ P4, TK +/P4.3.4, and TK +/- 3.7.2C cells have similar, if not the same, characteristics. The small amounts of TK associated with TK -/P4.3 and the mitochondria from TK +/+ P4 had similar characteristics, and both were different in many respects from the TK associated with the TK +/+ P4, TK +/- P4.3.4, and TK +/-3.7.2C. These results raise a question about whether a structural gene is the target for chemical mutagens in the L5178Y TK +/assay, however, this can only be answered by the isolation of the TK gene from each of the L5178Y genotypes and determination of the nucleotide sequence.
JF  - Toxicology and Industrial Health
AU  - Palmer, Kenneth A
AU  - De Giovanni-Donnelly, Rosalie
AD  - Genetic Toxicology Branch, Food and Drug Administration Washington, D.C
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 1
EP  - 12
PB  - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK
VL  - 1
IS  - 3
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts; Immunology Abstracts
KW  - L5178Y TK +/- assay, mouse lymphoma, thymidine kinase.
KW  - Temperature effects
KW  - Mutagens
KW  - Isoelectric points
KW  - Nucleotide sequence
KW  - Mitochondria
KW  - Enzymes
KW  - Thymidine kinase
KW  - Genotypes
KW  - TK gene
KW  - Protein-tyrosine kinase
KW  - Lymphoma
KW  - Mutation
KW  - F 06955:Immunomodulation & Immunopharmacology
KW  - X 24350:Industrial Chemicals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760215807?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Characterization+of+Thymidine+Kinase+in+L5178y+mOuse+Lymphoma+Cells&rft.au=Palmer%2C+Kenneth+A%3BDe+Giovanni-Donnelly%2C+Rosalie&rft.aulast=Palmer&rft.aufirst=Kenneth&rft.date=1985-01-01&rft.volume=1&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378500100301
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-10-01
N1  - Number of references - 12
N1  - Last updated - 2015-04-02
N1  - SubjectsTermNotLitGenreText - Temperature effects; Mutagens; Isoelectric points; Nucleotide sequence; Protein-tyrosine kinase; Enzymes; Mitochondria; Thymidine kinase; Genotypes; Mutation; Lymphoma; TK gene
DO  - http://dx.doi.org/10.1177/074823378500100301
ER  - 



TY  - GEN
T1  - Public Law 94-437 Title I Scholarship Program. Student Handbook, Academic Year 1985-86.
AN  - 63386741; ED257607
AB  - This handbook is for the use of recipients of any of the three interrelated scholarship programs (Health Professions Preparatory Scholarship, Health Professions Pregraduate Scholarship, and Health Professions Scholarship) implemented to train the professional health personnel to staff Indian Health Service (IHS) programs to satisfy the requirements of the Indian Health Care Improvement Act, Public Law 94-437. The introduction notes the handbook provides immediate access to guidance for situations not before encountered, the names and addresses of IHS scholarship personnel, and necessary forms. These forms include the enrollment and initial program progress report which must be filled out at the beginning of each semester, tutorial assistance request forms, and applications for extern selection. Five types of grant action are described in the handbook: initial, continuation, supplemental, change-administrative, and extension awards. A description of scholarship benefits discusses how the IHS pays for tuition and related fees, including equipment and travel reimbursement, and describes fees not covered by the program. A student service agreement which obligates the graduate to work for IHS a minimum of two years is discussed as well as the penalties and fines for noncompliance or academic failure. Government job applications and a study plan example are provided in the appendix. (PM)
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 94
KW  - Indian Health Care Improvement Act
KW  - Indian Health Service
KW  - ERIC, Resources in Education (RIE)
KW  - Students
KW  - Parents
KW  - Student Financial Aid
KW  - Postsecondary Education
KW  - Scholarships
KW  - American Indian Education
KW  - Human Resources
KW  - Student Responsibility
KW  - Instructional Student Costs
KW  - American Indians
KW  - Qualifications
KW  - Medical Education
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63386741?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Indian Health Service: A Comprehensive Health Care Program for American Indians and Alaska Natives.
AN  - 63294159; ED262940
AB  - Comprehensive health care (preventive, curative, rehabilitative, and environmental) for more than 930,000 eligible American Indians and Alaska Natives is the responsibility of the Indian Health Service (IHS). Since 1955, this agency of the U.S. Public Health Service has made notable progress in raising the health status of Indians and Alaska Natives, following policies outlined in Public Laws 93-638, 94-437, and 96-537. IHS operates 48 hospitals, 72 health centers, 12 school health centers, and more than 500 health stations and clinics which provide primary care, preventive health services, community health nursing, dental services, medical social work, environmental health services, and health education. Over 50% of the IHS staff is of native descent. IHS provides recruitment and career development activities for nurses, community health representatives and aides, technicians, dental/optometric assistants, mental health workers, and nutrition/dietetic workers. The most serious health related problems existing in high proportions among Indians and Alaska Natives are injuries, alcoholism, mental health problems, middle ear diseases, diabetes, nutritional deficiencies, and poor dental health. Other major health concerns are maternal and child health needs, unhealthy environmental conditions, and problems associated with aging. Maps and tables indicate IHS facilities, vital statistics, and services rendered. Photographs and IHS administrative office addresses are included. (NEC)
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 32
KW  - Indian Health Service
KW  - ERIC, Resources in Education (RIE)
KW  - Program Descriptions
KW  - Health Programs
KW  - Health Facilities
KW  - Program Effectiveness
KW  - Rehabilitation
KW  - Delivery Systems
KW  - American Indians
KW  - Health Services
KW  - Health Needs
KW  - Public Health
KW  - Health Personnel
KW  - Statistical Data
KW  - Preventive Medicine
KW  - Alaska Natives
KW  - Medical Services
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63294159?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - Photographs may not reproduce well.
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Preventing Sexual Abuse in Day Care Programs: National Program Inspection.
AN  - 63289940; ED260836
AB  - In October 1984, a national program inspection on preventing child sexual abuse in day care programs was begun. Program inspections are short-term studies designed to provide qualitative information and quantitative data for use by the Department of Health and Human Services as an additional source of information. Participants in this study, from 49 states and the District of Columbia, included state child protective staff and social workers, state licensing officials, city and county licensing officials, state criminal identification system directors, physicians, sexual assault therapists, child psychologists, district attorneys, police investigators, other experts in the field of child sexual abuse, day care providers, parents of children in day care, and special interest organizations. Brief statements of major findings; recommendations for education, research, and screening; and cost implications are followed by a background discussion of child sexual abuse and additional discussions of (1) Public Law 98-473 and the FBI criminal record system; (2) current screening practices in the states; (3) the potential scope of screening; (4) the potential cost of screening; (5) the effectiveness of screening; (6) and education for prevention. (RH)
AU  - Zimlich, Norm
Y1  - 1985/01//
PY  - 1985
DA  - January 1985
SP  - 27
KW  - Criminal Records
KW  - Screening Procedures
KW  - Screening Programs
KW  - ERIC, Resources in Education (RIE)
KW  - Program Effectiveness
KW  - Young Children
KW  - National Programs
KW  - Intervention
KW  - Early Childhood Education
KW  - Identification
KW  - Prevention
KW  - Federal Legislation
KW  - Day Care
KW  - Psychological Characteristics
KW  - Cost Estimates
KW  - Sexual Abuse
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63289940?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - Last updated - 2014-03-21
ER  - 



TY  - GEN
T1  - Model Child Care Standards Act--Guidance to States to Prevent Child Abuse in Day Care Facilities.
AN  - 63283805; ED264697
AB  - The document offers guidelines to states regarding review and revision of child care statutes, standards, and policies to address the prevention of child sexual abuse in day care facilities. General information is also provided on changes in state standards in recent years. Each of six sections examines findings of the 1981 Comparative Licensing study and reports results of the Department's review in 1984 of all current and some proposed state licensing standards and registration requirements. The following areas are addressed: parent visitation and other parent participation (the role of parents in preventing child sexual abuse); employment history checks of staff and other background screening (criminal records checks, FBI checks); staff qualification requirments by job classification; probationary periods for new staff; staff training, development, supervision and evaluation; and staff-child ratios. Appendixes include summaries of qualifications by job classification and of staff-child ratio requirements. (CL)
Y1  - 1985/01//
PY  - 1985
DA  - January 1985
SP  - 157
KW  - ERIC, Resources in Education (RIE)
KW  - Policymakers
KW  - Facility Requirements
KW  - Prevention
KW  - State Legislation
KW  - Staff Role
KW  - Day Care
KW  - Sexual Abuse
KW  - Certification
KW  - Staff Development
KW  - Family Day Care
KW  - Day Care Centers
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63283805?accountid=14244
LA  - English
DB  - ERIC
N1  - Availability - Level 1 - Available online, if indexed January 1993 onward
N1  - SuppNotes - Appendices A, "Accreditation Criteria and Procedur
N1  - Last updated - 2014-03-21
ER  - 



TY  - BOOK
T1  - National directory, training and employment programs for Americans with disabilities
AN  - 36853150; 816283
JF  - National directory, training and employment programs for Americans with disabilities
Y1  - 1985
PY  - 1985
DA  - 1985
EP  - 374
PB  - The Department
KW  - Economics
KW  - Directories
KW  - Disabled workers
KW  - Disabled rehabilitation
KW  - U.S.A.
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36853150?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/International+Bibliography+of+the+Social+Sciences+%28IBSS%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=vii&rft.isbn=&rft.btitle=National+directory%2C+training+and+employment+programs+for+Americans+with+disabilities&rft.title=National+directory%2C+training+and+employment+programs+for+Americans+with+disabilities&rft.issn=&rft_id=info:doi/
LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - SuppNotes - ill.
N1  - Last updated - 2013-09-16
ER  - 



TY  - JOUR
T1  - Survey of 2,3,7,8-Tetrachlorobidenzo-p-dioxin in Fish from the Great Lakes and Selected Michigan Rivers
AN  - 18992861; 8601527
AB  - Residues of 2,3,7,8-tatrachlorodibenzo-p-dioxin (TCDD) were measured in fish taken from the Great Lakes. Fish from the Saginaw Bay (Lake Huron), the Tittabawassee River in Michigan, and Lake Ontario contained the highest levels of contamination. No TCDD residues at or above the minimum confirmable level of 10 ppt were found in fish from Michigan rivers other than the Tittabawassee. Comparison of the current findings with the results of an earlier study, 1983, suggests a decrease in residue levels with time. Detectable levels of TCDD were found only in carp, catfish, salmon, white perch and trout. No residues at or above the 10 ppt level were found in sucker, whitefish, yellow perch, walleye, bullhead, crappie, bowfin, rockbass, buffalo, white bass, and sheepshead. (Baker-IVI)
JF  - Journal of Agricultural and Food Chemistry Vol. 33, No. 4, p 626-630, 1985. 3 Fig, 2 Tab, 12 Ref.
AU  - Fehringer, N V
AU  - Walters, S M
AU  - Kozara, R J
AU  - Schneider, L F
AD  - Food and Drug Administration Detroit, MI. Pesticide and Industrial Chemical Research Center
Y1  - 1985
PY  - 1985
DA  - 1985
KW  - Water Resources Abstracts
KW  - Great Lakes
KW  - Michigan
KW  - Rivers
KW  - Pesticide residues
KW  - Tetrachlorodibenzo-p-dioxin
KW  - Saginaw Bay
KW  - Lake Huron
KW  - Tittabawassee River
KW  - Lake Ontario
KW  - Dioxin
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Unindexed Middle Matter
AN  - 1519945139
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 1
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Back Matter
AN  - 1519944371
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Unindexed Front Matter
AN  - 1519944208
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 91
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Unindexed+Front+Matter&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-01-01&rft.volume=10&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - PAT
T1  - Immortal line of human fetal glial cells.
AN  - 14853959; 1685718
AU  - Major, E O
PY  - 1985
IS  - US Patent 4,707,448
KW  - cell lines
KW  - glial cells
KW  - man
KW  - patents
KW  - Biotechnology and Bioengineering Abstracts
KW  - W 30050:Patents
KW  - W 30330:Animals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14853959?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Immortal+line+of+human+fetal+glial+cells.&rft.au=Major%2C+E+O&rft.aulast=Major&rft.aufirst=E&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/240.25; Int. Cl. C12N 5/00.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Alcohol and Sexual Dysfunction
AN  - 1474330058
AB  - A survey of research into the effects of alcohol on human sexuality.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 10
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474330058?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Alcohol+and+Sexual+Dysfunction&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-01-01&rft.volume=10&rft.issue=2&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Reader's Exchange: Use of Family Treatment Methods by Alcoholism Treatment Services
AN  - 1474329865
AB  - Survey results suggest that a broad variety of treatment programs in 37 States offer services to the families of alcoholic patients.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 44
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474329865?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+Health+and+Research+World&rft.atitle=Reader%27s+Exchange%3A+Use+of+Family+Treatment+Methods+by+Alcoholism+Treatment+Services&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-01-01&rft.volume=10&rft.issue=2&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Alcohol+Health+and+Research+World&rft.issn=0090838X&rft_id=info:doi/
DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Epidemiologic Bulletin 10
AN  - 1474329732
AB  - 1983 Alcohol/Health Practices Supplement
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 48
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474329732?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol and Drug Abuse Among American Military Personnel: Prevalence and Policy Implications
AN  - 1474328524
AB  - The most recent worldwide survey.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 16
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1474328524?accountid=14244
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Reader's Exchange: Self-Handicapping Alcohol Abuse
AN  - 1474328391
AB  - Can stress derived from success precipitate alcohol problems?
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 46
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol, Spirituality, and Recovery
AN  - 1474328235
AB  - The recovery process is explored in interviews with practitioners.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 28
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Domestic Violence and Alcohol: Barriers to Cooperation
AN  - 1474326924
AB  - A review of programmatic issues.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 22
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The NIAAA Laboratory of Preclinical Studies
AN  - 1474326473
AB  - Intramural investigators seek to understand alcohol dependence, tolerance, and withdrawal.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 2
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcoholic Hepatitis
AN  - 1474326144
AB  - A primer that answers commonly asked questions about this liver disease.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 40
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Safety Update
AN  - 1474325600
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 58
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Newsnotes
AN  - 1474325165
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 57
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol Problems and Homelessness: Findings from the Ohio Study
AN  - 1474325164
AB  - A statistical examination of alcohol problems among the homeless.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 14
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - The Occupational Arena
AN  - 1474303362
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 59
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Research Reports
AN  - 1474300953
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 56
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Alcohol Abuse and Digestive Diseases
AN  - 1474300920
AB  - How does alcohol interact with the digestive system?
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 6
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - JOUR
T1  - Statistics in Research Reports: A Reader's Guide
AN  - 1474300866
AB  - The third and final article in a series on statistics for research consumers.
JF  - Alcohol Health and Research World
Y1  - 1985///Winter
PY  - 1985
DA  - Winter 1985
SP  - 32
CY  - Rockville
PB  - Public Health Service, National Institutes of Health
VL  - 10
IS  - 2
SN  - 0090-838X
KW  - Drug Abuse And Alcoholism
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DB  - Periodicals Archive Online; Periodicals Index Online
N1  - Last updated - 2014-04-30
ER  - 



TY  - BOOK
T1  - Design of pregnancy outcome studies of industrial exposures.
AN  - 14585152; 1467874
AB  - A number of factors affect the study of industrial exposures and pregnancy outcome. The two primary factors to be considered in the design of this research are the continuum of outcomes that may be observed, and their relationship to degree of exposure (dose). A dose-response relationship for a specific outcome may only be observed within a limited range of doses. As a result, the characterization of exposure, both in terms of levels and types of exposure, may provide much information. Cohort studies of industrial populations may be preferable for studies of a specific exposure, since more detailed exposure data are available and, given large enough populations, multiple outcomes may be examined. Case-control studies are useful for the evaluation of a relationship between one specific outcome and the exposure(s) of interest.
AU  - Selevan, S G
A2  - Hemminki, K
A2  - Sorsa, M
A2  - Vainio, H (eds)
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 11
EP  - 229
SN  - 089116281X
KW  - effects on
KW  - study methodology
KW  - man
KW  - reproductive pathology
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - reviews
KW  - hazards
KW  - pregnancy
KW  - occupational exposure
KW  - X 24221:Toxicity testing
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Performance of sulfur dioxide passive monitors.
AN  - 14495127; 1407362
AB  - The following four commercial sulfur dioxide passive monitors were tested for performance and realiability: DuPont Pro-Tek) C-20 air monitoring badges; MSA Vaporgard super(TM) Dosimeter tubes; REAL BioBadges; and 3M Sulfur Dioxide Nutshell monitors. The experiments conducted were designed to test factors critical to the operation of passive samplers; accuracy and precision; capacity; stability; analytical recovery; and the effect of exposure time, concentration, humidity, face velocity, orientation, chemical interference, and temperature. The DuPont Pro-Tek badges performed satisfactorily for all the factors tested, and the REAL BioBadges performed satisfactorily except for the instability of the SO sub(2)/tetrachloromercurate complex when stored. An alternate monitoring system, REAL BioBadges containing deionized water absorbent had a limited capacity. Only the MSA dosimeters exhibited unsatisfactory performance. The 3M Nutshell monitor was withdrawn by the manufacturer after only partial evaluation.
JF  - American Industrial Hygiene Association Journal
AU  - Cassinelli, ME
AU  - Hull, R D
AU  - Cuendet, P A
AD  - NIOSH, Div. Phys. Sci. and Eng., Methods Res. Branch, Switzerland
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 599
EP  - 608
VL  - 46
IS  - 10
SN  - 0002-8894, 0002-8894
KW  - monitoring instruments
KW  - sulfur dioxide
KW  - air quality
KW  - performance
KW  - Toxicology Abstracts; Pollution Abstracts
KW  - pollution monitoring
KW  - air pollution
KW  - P 0000:AIR POLLUTION
KW  - X 24222:Analytical procedures
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - monitoring instruments; sulfur dioxide; air quality; performance; pollution monitoring; air pollution
ER  - 



TY  - JOUR
T1  - Use of tracer gas techniques for industrial exhaust hood efficiency evaluation - application of sulfur hexafluoride for hood controlling particulate emissions.
AN  - 14479675; 1383747
AB  - One of the most commonly used controls of harmful industrial contaminants is a local exhaust hood. The efficiency of this system is defined as the ratio of air contaminant quantify captured by the system per unit time to the total contaminant quantify produced by the process per unit time. A tracer gas technique, using sulfur hexafluoride (SF sub(6)), has been developed for the efficiency estimation of hoods controlling gaseous or vaporous contaminants. To extend the applicability of this method to hoods controlling particulate contaminants, a relationship between the hood particle capture efficiency and the hood efficiency determined by the tracer gas technique was studied. A particulate tracer was used for the hood efficiency and the data were compared with those obtained by the SF sub(6) technique. Both tracers were discharged under the same conditions. Based on a statistical data analysis, described in detail in this paper, a mathematical relationship between the efficiency obtained by both particulate and SF sub(6) was obtained for different velocity ratios (discharge velocity to capture velocity). For a hood controlling particles of 3 mu m in diameter, no correction of the hood efficiency data estimated by the SF sub(6) technique is required. For larger particles, a corrective factor should be used for modification of the efficiency results obtained by the SF sub(6) techni
JF  - American Industrial Hygiene Association Journal
AU  - Hampl, V
AU  - Shulman, S
AD  - NIOSH, Div. Phys. Sci. and Eng., Robert A. Taft Lab., Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 379
EP  - 386
VL  - 46
IS  - 7
SN  - 0002-8894, 0002-8894
KW  - Pollution Abstracts
KW  - exhaust emissions
KW  - particulates
KW  - gases
KW  - tracers
KW  - industrial emissions
KW  - pollution control
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - tracers; gases; industrial emissions; exhaust emissions; particulates; pollution control
ER  - 



TY  - JOUR
T1  - Control of wood dust from horizontal belt sanding.
AN  - 14474184; 1380582
AB  - An auxiliary ventilation system has been developed to reduce the wood dust emission from horizontal belt sanders. This system consists of two devices: a hood and a jet stripper. The hood is a narrow low-volume, high-velocity slot hood located between a belt surface and a worktable; the push device is a jet stripper located inside a driven pulley hood opposite the operator site. In combination with a standard sander hood, both devices significantly reduced to wood dust emission into the workroom. Laboratory data were confired by field tests conducted at an osillating edge belt sander at a wood furniture manufacturing plant. These devices work independently of each other and do not interfere with the operator's sanding activity. They do not require special maintenance and are economically feasible.
JF  - American Industrial Hygiene Association Journal
AU  - Hampl, V
AU  - Johnston, O E
AD  - NIOSH Div. Phys. and Eng., Robert A. Taft Lab., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 567
EP  - 577
VL  - 46
IS  - 10
SN  - 0002-8894, 0002-8894
KW  - Pollution Abstracts
KW  - wood
KW  - emission control
KW  - feasibility studies
KW  - control systems
KW  - ventilation
KW  - dust
KW  - economics
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ventilation; dust; wood; emission control; control systems; economics; feasibility studies
ER  - 



TY  - JOUR
T1  - The chronic effects of mechanical trauma to the skin: A review of the literature.
AN  - 14473759; 1385357
AB  - This paper summarizes the findings of NIOSH reported entitled "The Chronic Effects of Repeated Mechanical Trauma to the Skin: A Description of the Problem in the Workplace" (the Trauma Report). Medical literature and U.S. health statistics were reviewed to determine the long-range impact of repeated mechanical trauma sustained in the workplace. Trauma was rarely recognized as contributing to dermatological disorders. Conventional sources of information were found to be inadequate for precise estimation of costs. A minimal estimate of the annual cost of cutaneous disorders resulting from repeated mechanical trauma to the skin is $15 million.
JF  - American Journal of Industrial Medicine
AU  - Susten, A S
AD  - NIOSH, Div. Biomed. and Behav. Sci., Exp. Toxicol. Branch, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 281
EP  - 288
VL  - 8
IS  - 4-5
SN  - 0271-3586, 0271-3586
KW  - trauma
KW  - dermatology
KW  - occupational injuries
KW  - Health & Safety Science Abstracts
KW  - economics
KW  - skin
KW  - H SM9.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - skin; economics
ER  - 



TY  - JOUR
T1  - Skin effects of occupational kneeling.
AN  - 14472754; 1385340
AB  - To evaluate chronic knee trauma associated with kneeling, the authors conducted a cross-sectional questionnaire survey among floorlayers and tilelayers, two trades that require kneeling. Bricklayers and millwrights were studied for comparison. Approximately 28% of the 432 questionnaire respondents volunteered for a subsequent medical examination. Ultimately, data were analyzed for 112 floorlayers, 50 tilesetters, and 235 "comparison worker. They found that the history of past skin infection in the knee area was about four times more prevalent among floorlayers (7.1%) than among workers in the other two categories combined (1.8%). Unilateral or bilateral patellar skin thickening and erythema were found to be more prevalent among those who kneel: 79% of floorlayers and 98% of tilelayers vs 35% of the control group were found to have skin thickening; 52% of floorlayers and 49% of tilelayers vs 24% of the control group were found to have erythema on the frontal aspect of the knee.
JF  - American Journal of Industrial Medicine
AU  - Tanaka, S
AU  - Halperin, W E
AU  - Smith, AB
AU  - Lee, ST
AU  - Luggen, ME
AU  - Hess, E V
AD  - Div. Surveill., Hazard Eval. and Field Stud., NIOSH, Cent. Dis. Control, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 341
EP  - 349
VL  - 8
IS  - 4-5
SN  - 0271-3586, 0271-3586
KW  - occupational injuries
KW  - Health & Safety Science Abstracts
KW  - statistical analysis
KW  - surveys
KW  - H SM9.1:BASIC APPROACHES, CONCEPTS, AND THEORY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - surveys; statistical analysis
ER  - 



TY  - JOUR
T1  - Industrial hygiene characterization of automotive wood model shops.
AN  - 14403116; 1315153
AB  - A suspicion of an excess cancer risk in automotive model shops prompted the Industrywide Studies Branch, NIOSH, to conduct a proportionate mortality study and an industrial hygiene characterization of operations in these shops. The mortality study showed a statistically significantly excess proportion of deaths due to colon cancer and leukemia (for woodshops only). The materials used in the model shops include various natural woods, laminated woods, plastics, resins, varnishes, putties and paints. Personal breathing zone samples were collected for total and respirable dust, amines, various hydrocarbons (including styrene, and toluene), formaldehyde, and nitrosamines. Particle size distribution studies were conducted on the wood dust and bulk airborne samples of dusts were subjected to various mutagenicity test systems. Work practices, ventilation and general housekeeping were checked. Total wood dust samples ranged from 0.03 to 25 mg/m super(3) with an average around 1.0 mg/m super(3). The percent respirable dust ranged from 19 to 38% as measured with Andersen impactors. Solvent exposure samples ranged from non-detectable to about 10% of the OSHA Permissible Exposure Levels. Relevant recommendations for improvement of contaminant control were made.
JF  - American Industrial Hygiene Association Journal
AU  - McCammon, CS Jr
AU  - Robinson, C
AU  - Waxweiler, R J
AU  - Roscoe, R
AD  - Industrywide Stud. Branch, Div. Surveill., Hazard Eval. and Field Stud., NIOSH,, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 343
EP  - 349
VL  - 46
IS  - 7
SN  - 0002-8894, 0002-8894
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - wood
KW  - toluene
KW  - air quality
KW  - automotive industry
KW  - styrene
KW  - formaldehyde
KW  - dust
KW  - hydrocarbons
KW  - occupational health
KW  - ventilation
KW  - amines
KW  - leukemia
KW  - particle size
KW  - mortality
KW  - cancer
KW  - H ST2.1:BASIC APPROACHES, CONCEPTS, AND THEORY
KW  - H SM10.21:CANCER
KW  - H SM10.27:LEUKEMIA
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cancer; automotive industry; mortality; leukemia; particle size; ventilation; wood; dust; air quality; amines; hydrocarbons; styrene; toluene; formaldehyde; occupational health
ER  - 



TY  - JOUR
T1  - Health Hazard Evaluation Report HETA 83-044-1596, General Electric Plant, Evendale, Ohio.
AN  - 14402864; 1315160
AB  - Environmental samples were analyzed asbestos (1332214) at General Electric (SIC-3724), Evendale, Ohio in January and July, 1983. The evaluation was requested confidentially because of concern about electricians who had worked in the heat treatment process building and were thought to have suffered adverse effects from exposure to an asbestos containing insulation material. Eleven current and former employees were interviewed. Only one material sample contained asbestos, 20 to 25 percent chrysotile (12001295). The authors conclude that a health hazard due to asbestos exposure existed in the past, but does not now exist. Recommendations include determining who has been exposed to asbestos, developing an asbestos screening program, and instituting an educational program for asbestos exposed employees.
JF  - . 1985.
AU  - Parrish, R G
AU  - Hartle, R
AU  - Groth, D
AD  - NIOSH, Cincinnati, OH, USA
Y1  - 1985
PY  - 1985
DA  - 1985
KW  - electric power plants
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - hazards
KW  - education
KW  - asbestos
KW  - occupational exposure
KW  - H SE4.20:POISONS AND POISONING
KW  - H SI5.20:ELECTRIC POWER INDUSTRIES
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - PB86-133691/GAR.
N1  - Last updated - 2015-04-07
ER  - 



TY  - JOUR
T1  - Uptake, translocation, and transformation of pentachlorophenol in soybean and spinach plants.
AN  - 14339532; 1178218
AB  - Soybean plants were grown for 90 days and spinach plants for 64 days in a mixture of sterilized greenhouse soil and sand containing 10 ppm pentachlorophenol. All plant parts and soil samples were extracted and separated into nonpolar and polar fractions. Major nonpolar and polar metabolites were identified by gas-liquid chromatography and mass spectrometry. Nonpolar fractions from both soybean and spinach plants were found to contain pentachlorophenol and its metabolites, 2,3,4,6-tetrachlorophenol, methoxytetrachlorophenol, 2,3,4,6-tetrachloroanisole, and pentachloroanisole. Cleavage of polar metabolites from the soybean plants by acid hydrolysis yielded organic solvent-extractable products. These products were identified as pentachlorophenol, 2,3,4,6-tetrachlorophenol, and methoxytetrachlorophenol. Cleavage of polar materials from spinach plants yielded only pentachlorophenol. The polar metabolites from the soybean plants were also subjected to enzymatic cleavage by beta -glucosidase.
JF  - Environmental Research
AU  - Casterline, JL Jr
AU  - Barnett, N M
AU  - Ku, Y
AD  - FDA, Div. Chem. Technol., Washington, DC 20204, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 101
EP  - 118
VL  - 37
IS  - 1
SN  - 0013-9351, 0013-9351
KW  - soils
KW  - pentachlorophenol
KW  - Pollution Abstracts
KW  - chromatography
KW  - plants
KW  - sampling instruments
KW  - mass spectroscopy
KW  - P 5000:LAND POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - plants; mass spectroscopy; chromatography; sampling instruments
ER  - 



TY  - JOUR
T1  - Reduction in levels of volatile n-nitrosamines in rubber nipples for babies' bottles.
AN  - 14339455; 1165768
AB  - Levels of volatile N-nitrosamines were determined in 189 samples of rubber nipples for babies' bottles. Domestic (US-manufactured) and imported rubber nipples for consumer and hospital use were analysed to determine compliance with the US Food and Drug Administration's action level of 60 ppb for total volatile N-nitrosamines. Only one sample was found to be in violation of the action level; it contained a total of 137 ppb N-nitrosamines.
JF  - Food and Chemical Toxicology
AU  - Havery, DC
AU  - Perpetti, G A
AU  - Canas, B J
AU  - Fazio, T
AD  - Div. Chem. and Phys., FDA, Washington, DC 20204, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 991
EP  - 993
VL  - 23
IS  - 11
SN  - 0278-6915, 0278-6915
KW  - nipples
KW  - U.S. FDA
KW  - N-nitrosamines
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - rubber products
KW  - pollution control
KW  - P 9000:ENVIRONMENTAL ACTION
KW  - H SE4.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - rubber products; pollution control
ER  - 



TY  - JOUR
T1  - An overview of environmental and toxicological aspects of aromatic hydrocarbons. III. Xylene.
AN  - 14330324; 1141260
AB  - The commercial product "mixed xylenes" analogously to toluene is an agent of major chemical and occupational significance. It is produced in very large quantities and is extensively employed in a broad spectrum of applications, primarily as a solvent for which its use is increasing as a "safe" replacement for benzene, and in gasoline as part of the BTX component (benzene-toluene-xylene); xylenes are also frequently used in the rubber industry with other solvents such as toluene and benzene. As individual isomers they are extensively employed in the syntheses of synthetic agents, for example phthalic acid, isophthalic acid, terephthalic acid and dimethylterephthalate, which have very broad applications in the further preparation of phthalate ester plasticizers and components of polyester fiber, film and fabricated items. Coal-based solvents (e.g., xylene) have been suggested to be possibel potet lymphocytic leukemogens, in a limited study of the relationship betweenlymphocytic leukemia and exposures to benzene and other solvents in the rubber industry. In limited studies thus far, the individual isomers have not been found genotoxic when tested in a number of short-term tests.
JF  - Science of the Total Environment
AU  - Fishbein, L
AD  - DHHS, FDA, Natl. Cent. ToxicoL. Res., Jefferson, AR 72079 USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 165
EP  - 183
VL  - 43
IS  - 1-2
SN  - 0048-9697, 0048-9697
KW  - toxicity
KW  - xylene
KW  - occupational health
KW  - man
KW  - Toxicology Abstracts; Pollution Abstracts
KW  - toxicology
KW  - solvents
KW  - aromatic compounds
KW  - hydrocarbons
KW  - X 24151:Acute exposure
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - xylene; toxicology; occupational health; solvents; aromatic compounds; hydrocarbons; man
ER  - 



TY  - JOUR
T1  - In vitro biologic toxicity of native and surface-modified silica and kaolin.
AN  - 14323876; 1144001
AB  - An in vitro study of the biologic responses of surface-modified and native silica and kaolin was made to provide comparative information on the supression of cytotoxicity by pulmonary surfactant. The release of alveolar macrophage cytoplasmic enzyme, lactate dehydrogenase (LDH), and lysosomal enzymes beta -N-acetylglucosaminidase ( beta -NAG) and beta -glucuronidase ( beta -GLUC) and sheep blood-cell hemolysis were monitored as indicators of cell membrane damage and cytotoxicity. Surface modification of silica and kaolin with dipalmitoyl lecithin (DPL) resulted in complete abrogation of cytotoxicity of both minerals. These findings indicate that surface modification of minerals with different adsorption properties by pulmonary surfactant generally lessens their prompt adverse effects.
JF  - Journal of Toxicology and Environmental Health
AU  - Wallace, WE Jr
AU  - Vallyathan, V
AU  - Keane, MJ
AU  - Robinson, V
AD  - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 415
EP  - 424
VL  - 16
IS  - 3-4
SN  - 0093-4108, 0093-4108
KW  - kaolin
KW  - enzymatic activity
KW  - silica
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - toxicity
KW  - enzymes
KW  - X 24155:Biochemistry
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - silica; toxicity; enzymes; enzymatic activity
ER  - 



TY  - JOUR
T1  - Longitudinal decline in FEV sub(1) in United States coalminers.
AN  - 14317225; 1142769
AB  - Changes in ventilatory funtion measurements of United States miners who had participated in two surveys held nine years apart were analysed in relation to smoking habits, dust exposure, and other factors. The results showed trends similar to those reported among British miners. Loss of FEV sub(1) over time and found to be related to smoking (0 multiplied by 1 litre excess decline in current smokers compared with those who had never smoked over 11 years) and to occupational exposure (0 multiplied by 036-0 multiplied by 84 litres over 11 years, depending on the index used). The results offer confirmation of the relationship between work in coal mines and loss in ventilatory function observed in British miners, and also seen in cross sectional studies.
JF  - Thorax
AU  - Attfield, MD
AD  - Appalachian Lab. Occup. Saf. and Health, NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 132
EP  - 137
VL  - 40
IS  - 2
SN  - 0040-6376, 0040-6376
KW  - effects on
KW  - Toxicology Abstracts
KW  - USA
KW  - coal
KW  - respiratory function
KW  - occupational exposure
KW  - man
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - USA; coal; occupational exposure; respiratory function; man
ER  - 



TY  - JOUR
T1  - An analysis of exposure to styrene in the reinforced plastic boat-making industry.
AN  - 14316542; 1130132
AB  - The evaluate patterns of occupational exposure to styrene monomer in the boat-building industry, the authors conducted industrial hygiene surveys in seven fiberglass-reinforced plastic boat-fabrication plants. A total of 397 personal breathing zone air samples were collected on workers in four key job categories. Exposure to styrene in 234 (59%) of the personal samples exceeded the NIOSH-recommended time-weighted average (TWA) standard of 50 parts per million (ppm), and 96 (24%) of these samples exceeded the OSHA eight-hour TWA permissible exposure limit of 100 ppm. Exposures in these jobs appear to be proportional to resin consumption. Statistical analyses indicated that the parameter that most affects exposure potential is job category. Within a job category, part size, configuration, and surface area are important determinants of exposure. The principal reason for high exposures was the absence of control technologies and, in particular, the absence of adequate ventilation.
JF  - American Journal of Industrial Medicine
AU  - Crandall
AU  - Hartle, R W
AD  - U.S. DHHS, Public Health Serv., Cent. Dis. Control, NIOSH, Div. Surveill., Hazard Eval. and Field Stud., Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 183
EP  - 192
VL  - 8
IS  - 3
SN  - 0271-3586, 0271-3586
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - plastics
KW  - styrene
KW  - occupational health
KW  - ventilation
KW  - ships
KW  - H SI7.8.2:CHEMICALS (CORROSION)
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; styrene; plastics; ventilation; ships
ER  - 



TY  - JOUR
T1  - Effect of nitro substitution on the light-mediated mutagenicity of polycyclic aromatic hydrocarbons in Salmonella typhimurium TA98.
AN  - 14311235; 1138515
AB  - In this study, the authors have determined the effect of nitro substitution on the light-mediated mutagenicity of 4 PAHs. Benzo(a)pyrene, benzo(e)pyrene, benz(a)anthracene and fluorene and their major nitration products, 6-nitrobenzo(a)pyrene, 3-nitrobenzo(e)pyrene, 7-nitrobenz( alpha )anthracene and 2-nitrofluorene, were exposed to simulated sunlight or cool-white light and then assayed for mutagenicity using the S. typhimurium reversion assay. They have found that nitration increased the light-mediated mutagenic activity of each of these PAHs.
JF  - Mutation Research
AU  - White, G L
AU  - Fu, P P
AU  - Heflich, R H
AD  - DHHS, FDA, Natl. Cent. Toxicol. Res., Jefferson, AR 72079, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 1
EP  - 7
VL  - 144
IS  - 1
SN  - 0027-5107, 0027-5107
KW  - nitro substitution
KW  - laboratory testing
KW  - Pollution Abstracts; Health & Safety Science Abstracts; Genetics Abstracts; Toxicology Abstracts
KW  - mutation
KW  - mutagenicity
KW  - Ames test
KW  - genetics
KW  - polycyclic aromatic hydrocarbons
KW  - H SM5.8.2:CHEMICALS (CORROSION)
KW  - X 24200:Nitrosamines & related compounds
KW  - X 24190:Polycyclic hydrocarbons
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - G 07221:Specific chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - polycyclic aromatic hydrocarbons; mutagenicity; Ames test; mutation; laboratory testing; genetics
ER  - 



TY  - CONF
T1  - Distribution based definition of impulse noise.
AN  - 14303042; 1138329
AB  - Existing definitions of impulse noise are based on estimates of either the decay of the noise envelope, the repetition rate of the peaks, or a comparison of single peak level to rms level. Because each of these measures fails to fully characterize at least one of the relevant characteristics of an impulse, many exceptions to these classifications can be found. An improved alternative classification should be independent of absolute pressure magnitude, impulse duration, and repetition rate; yet, it should incorporate all these on a relative basis. The kurtosis (b sub(2)) of the amplitude distribution of a sampled impulse is such a descriptor. Examination of distribution kurtosis over samples of 1, 5, 11, and 42 s suggests that the "impulsiveness" of an exposure may be characterized by this statistic.
JF  - Journal of the Acoustical Society of America
AU  - Erdreich, J
Y1  - 1985
PY  - 1985
DA  - 1985
VL  - 77
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - waves
KW  - acoustic measurements
KW  - noise levels
KW  - H SE3.22:NOISE (VIBRATION) POLLUTION
KW  - P 7000:NOISE
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14303042?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - Summary only.
N1  - Last updated - 2011-12-12
ER  - 



TY  - BOOK
T1  - From data to information to knowledge. The problems of metamorphosis.
AN  - 14301601; 1138416
AB  - Rational control of health and environmental risks from technical development requires scientific knowledge which must be acquired through the orderly process of the scientific method of inquiry. Contrary to widely held opinions the latter is no less subjective than other rational human endeavors which require decisions under uncertainty. Indeed, to be applied, the method requires a value system which in ordinary research is supplied by the various scientific disciplines. Because of differences among the disciplinary value systems problems often arise in the interdisciplinary settings of efforts to control risks from technical development. Metrics, the concepts, theory, and practice of measurement is suggested here as a way to deal with such problems.
JF  - ACS Symposium Series [ACS SYMP. SER.]. 1985.
AU  - Zervos, C
A2  - Kurtz, DA (ed)
Y1  - 1985
PY  - 1985
DA  - 1985
SN  - 0841209251
KW  - chemical pollutants
KW  - Pollution Abstracts
KW  - residues
KW  - data collection
KW  - risk assessment
KW  - public health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Mortality among retired fur workers dyers, dressers (tanners) and service workers.
AN  - 14282943; 1100352
AB  - A retrospective cohort mortality study was conducted on 807 fur dyers, fur dressers (tanners), and fur service workers who were pensioned between 1952 and 1977 by the Fur, Leather and Machine Workers Union of New York City. Workplace exposures of fur workers varied with job category. Dyers were exposed to oxidative dyes used in commercial hair dyes; dressers and service workers were exposed to tanning chemicals. In a comparison with the New York City population, no significant increases in mortality were observed among the fur dyers. Among fur dressers, mortality from all malignant neoplasms (standardized mortality ratio (SMR) 151) and lung cancer (SMR 232) was significantly elevated, as was mortality from cardiovascular disease (SMR 126) among fur service workers. When examined by ethnic origin, the elevated SMR values and directly age-adjusted rate ratios suggested that foreign-born fur dressers and eastern European-born fur workers experienced the highest risks for lung and colorectal cancers, respectively. These data support previous findings of increased mortality from colorectal cancer in the foreign-born population of the United States and suggest a possible occupational etiology for the observed lung cancer excess.
JF  - Scandinavian Journal of Work, Environment & Health
AU  - Sweeney, M H
AU  - Walrath, J
AU  - Waxweiler, R J
AD  - NIOSH, Robert A. Taft Lab., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 257
EP  - 264
VL  - 11
IS  - 4
SN  - 0355-3140, 0355-3140
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - dyes
KW  - occupational exposure
KW  - mortality
KW  - risk assessment
KW  - tanning industry
KW  - cancer
KW  - H SI2.29:TANNERIES
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - tanning industry; mortality; dyes; occupational exposure; cancer; risk assessment
ER  - 



TY  - JOUR
T1  - Muscle fatigue associated with repetitive arm lifts: Effects of height, weight and reach.
AN  - 14280439; 1110764
AB  - A simulated assembly-line task was constructed to investigate the metabolic cost and the pattern of muscular fatigue associated with selected arm lifts. The results indicated that the most fatiguing task variable was weight. At the heavier of the two levels, weight significantly increased the EMG amplitude of the deltoid, biceps and brachioradialis muscles. Significant increases in the EMG amplitude of the biceps were also found when the variable of height was adjusted to higher of two levels. Although not as dramatic as the increases in EMG activity, both heart rate and oxygen uptake were significantly increased when the variables of height and weight were at their maximum levels, i.e. eye level and 80% maximum voluntary contraction (MVC).
JF  - Ergonomics
AU  - Habes, D
AU  - Carlson, W
AU  - Badger, D
AD  - U.S. DHHS, Cent. Dis. Control, NIOSH, Div. Biomed. and Behav. Sci., Cincinnati, OH, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 471
EP  - 488
VL  - 28
IS  - 2
SN  - 0014-0139, 0014-0139
KW  - exercise
KW  - fatigue
KW  - Health & Safety Science Abstracts
KW  - physiology
KW  - ergonomics
KW  - occupational health
KW  - working conditions
KW  - H SI0.7:HUMAN FACTORS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - ergonomics; working conditions; occupational health; physiology
ER  - 



TY  - JOUR
T1  - Pattern of response of intact Drosophila to known teratogens.
AN  - 14277577; 1112261
AB  - Drosophila , as the test organism, was used to assess 17 chemicals. The teratogenic potential of 15 of these chemicals is well established from animal studies or human epidemiology. The test involves examination of adult flies following treatment during larval stages of development. Files are examined for abnormal external morphology. The incidence of abnormalities in treated and control populations is compared using the Chi-square test. All 17 chemicals were active to varying degrees in the test system. Most chemicals produced a unique response yielding individual patterns of abnormalities. These results suggest that Drosophila may have the potential to become a valuable teratogen screen, but further, more rigorous examination - particularly with nonteratogens - is required.
JF  - Journal of the American College of Toxicology
AU  - Schuler, R L
AU  - Radike, MA
AU  - Hardin, B D
AU  - Niemeier, R W
AD  - NIOSH, Mail Stop: C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 291
EP  - 303
VL  - 4
IS  - 4
SN  - 0730-0913, 0730-0913
KW  - testing
KW  - Entomology Abstracts; Toxicology Abstracts; Pollution Abstracts
KW  - toxicology
KW  - statistical analysis
KW  - Drosophilidae
KW  - morphology
KW  - teratogens
KW  - teratogenicity
KW  - Drosophila
KW  - X 24222:Analytical procedures
KW  - Z 05183:Toxicology & resistance
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Drosophila; Drosophilidae; teratogens; morphology; statistical analysis; toxicology; teratogenicity
ER  - 



TY  - JOUR
T1  - Effects of low dose rate (0 multiplied by 003 - 0 multiplied by 025 Gy/h) chronic X-irradiation on radioresistant and radiosensitive L5178Y mouse lymphoma cells.
AN  - 14273814; 1100652
AB  - Cultures of radioresistant (LY-R) and radiosensitive (LY-S) strains of L5178Y mouse lymphoma cells were exposed continuously to X-rays delivered at dose rates ranging from 0 multiplied by 003 to 0 multiplied by 025 Gy/h for up to 35 days. Populations of both strains proliferated actively during the exposure, but the growth rates were reduced in a dose rate-dependent manner. The reduction of growth rate occurred for strain LY-S earlier during the exposure and at lower dose rates than for strain LY-R. The results show that mutagenic and/or selective phenomena leading to an increase in radiation resistance of mammalian cells can be caused by protracted exposures to X-rays at dose rates permitting active proliferation.
JF  - International Journal of Radiation Biology
AU  - Beer, J Z
AU  - Mencl, J
AU  - Horng, M F
AU  - Gregg, E C
AU  - Evans, H H
AD  - Cent. Devices and Radiol. Health, FDA, Rockville, MD 20857, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 609
EP  - 620
VL  - 48
IS  - 4
SN  - 0955-3002, 0955-3002
KW  - X-ray radiation
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - mutagens
KW  - radiation dosimetry
KW  - cytology
KW  - H SM5.9.1:RADIATION HAZARDS
KW  - P 8000:RADIATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - radiation dosimetry; cytology; mutagens
ER  - 



TY  - JOUR
T1  - Pulmonary effects of acute vanadium pentoxide inhalation in monkeys.
AN  - 14271248; 1105407
AB  - An experimental study was conducted to investigate the hypothesis that changes in pulmonary function induced by vanadium pentoxide (V sub(2)O sub(5)) inhalation would be accompanied by evidence of pulmonary inflammation.
JF  - American Journal of Respiratory and Critical Care Medicine
AU  - Knecht, E A
AU  - Moorman, W J
AU  - Clark, J C
AU  - Lynch, D W
AU  - Lewis, T R
AD  - Div. Biomed. Behav. Sci., NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 1181
EP  - 1185
VL  - 132
IS  - 6
SN  - 0003-0805, 0003-0805
KW  - dust
KW  - vanadium
KW  - monitoring methods
KW  - vanadium pentoxide
KW  - monkeys
KW  - Toxicology Abstracts; Health & Safety Science Abstracts
KW  - inhalation
KW  - respiratory system
KW  - respiratory function
KW  - risk assessment
KW  - H SM9.31:INHALATION INJURIES
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - respiratory system; inhalation; vanadium; monitoring methods; risk assessment; respiratory function
ER  - 



TY  - JOUR
T1  - Accidental Cs-137 contamination.
AN  - 14269902; 1103483
AB  - Widespread use of radionuclides in medicine and industry poses the possibility of radiation accidents. The authors describe such an occurrence involving three industrial workers. The accident resulted from careless handling of a Cs-137 source. Evaulation of the Cs-137 whole body burden was carried out using stationary and scanning whole body counters. In addition, regional and whole body activity from contamination was assessed using an uncollimated gamma camera. This report emphasizes the value of the gamma camera for detection of radionuclide contamination in radiation accidents.
JF  - Radiology
AU  - Nishiyama, H
AU  - Saenger, EL
AU  - Grossman, L W
AU  - Lukes, S J
AD  - Nucl. Med. Lab., Div. Phys. Sci., OST, CDRH, FDA, Washington, DC 20204, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 513
EP  - 518
VL  - 154
IS  - 2
SN  - 0033-8419, 0033-8419
KW  - cesium-137
KW  - man
KW  - cesium
KW  - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - accidents
KW  - radioisotopes
KW  - occupational exposure
KW  - toxicology
KW  - X 24210:Radiation & radioactive materials
KW  - P 8000:RADIATION
KW  - H SI0.9.1:RADIATION HAZARDS
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; radioisotopes; cesium; toxicology; accidents; man
ER  - 



TY  - JOUR
T1  - Subchronic inhalation toxicity of isobutyl nitrite in BALB/c mice. II. Immunotoxicity studies.
AN  - 14268743; 1092820
AB  - Initial epidemiologic studies of acquired immunodeficiency syndrome (AIDS) occurring in homosexual men identified the use of the inhalants amyl, butyl, and isobutyl nitirte as possible risk factors contributing to the disease. The authors studied the effects of subchronic exposure to isobutyl nitrite (IBN) on the immune system. The lymphocyte proliferative response to mitogens (phytohemagglutinin, concanavalin A, pokeweed mitogen, and lipopolysaccharide) was tested using several concentrations of each mitogen. Additional mice were immunized with Freund's complete adjuvant 21 d prior to death and were tested for delayed hypersensitivity response to purified protein derivative by a radiometric skin test. Finally, the relative numbers of T cells and T-cell subsets among splenic lymphocytes from exposed and control animals were determined. At the time periods tested there were no discernable immunotoxic effects observed in the exposed animals in any of the assays performed. These results indicate that IBN, at the dosages tested, had no discernable detrimental effect on the immune system of mice.
JF  - Journal of Toxicology and Environmental Health
AU  - Lewis, D M
AU  - Koller, WA
AU  - Lynch, D W
AU  - Spira, T J
AD  - Immunol. Sect., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 835
EP  - 846
VL  - 15
IS  - 6
SN  - 0093-4108, 0093-4108
KW  - inhalation
KW  - association
KW  - effects on
KW  - isobutyl nitrite
KW  - mice
KW  - Immunology Abstracts; Toxicology Abstracts
KW  - immunosuppression
KW  - lymphocytes T
KW  - lymphocyte transformation
KW  - acquired immune deficiency syndrome
KW  - F 06791:Experimental
KW  - X 24180:Social poisons & drug abuse
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - acquired immune deficiency syndrome; lymphocyte transformation; lymphocytes T; immunosuppression
ER  - 



TY  - JOUR
T1  - Influence of genetic composition of test-animal populations on chronic toxicity studies used for risk estimation.
AN  - 14267556; 1102429
AB  - A lifespan exposure of mice to benzidine dihydrochloride was conducted for 33 m using both sexes of two populations of mice with the same gene pool. One population was the genetically homogeneous F sub(2) hybrid produced by crossing BALB/cStCrlC3Hf/Nctr males with C57BL/Nctr females. The second population consisted of genetically heterogenous monohybrid cross (MC) offspring produced by mating the F sub(1) hybrids inter se. Data comparisons were made to determine if gene distribution among members of a population affects the response to a toxic insult. The calculation of the liver tumor risk for these two populations showed that lifespan exposure to benzidine would be predicted to result in a larger number (higher risk) when using the F sub(1) data. A 4.5-fold difference in the toxic response was observed between the F sub(1) females and the MC males. This emphasizes the importance of gene distribution in risk estimation studies.
JF  - Journal of Toxicology and Environmental Health
AU  - Littlefield, NA
AU  - Wolff, G L
AU  - Nelson, C J
AD  - DHHS, F.D.A., Natl. Cent. Toxicol. Res., Jefferson, AR 72079, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 357
EP  - 368
VL  - 15
IS  - 3-4
SN  - 0093-4108, 0093-4108
KW  - risk assessment
KW  - genetic factors
KW  - benzidine dihydrochloride
KW  - mice
KW  - tumors
KW  - tumorigenicity
KW  - Toxicology Abstracts; Genetics Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - toxicity testing
KW  - toxicity
KW  - genetics
KW  - mortality
KW  - liver
KW  - G 07398:GENERAL
KW  - H SM5.8.2:CHEMICALS (CORROSION)
KW  - X 24221:Toxicity testing
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - genetics; toxicity; mortality; liver; mice; toxicity testing; tumors; tumorigenicity
ER  - 



TY  - JOUR
T1  - Subchronic inhalation toxicity of isobutyl nitrite in BALB/c mice. I. Systemic toxicity.
AN  - 14264943; 1093321
AB  - The effects of subchronic inhalation exposure to isobutyl nitrite (IBN) on body weight, selected organ weights, hematology, and gross pathology and histopathology of BALB/c mice were evaluated. Most changes in measured indices occurred in mice exposed at 300 ppm IBN and included decreased thymus weight (females); decreased liver weight (males); decreased white blood cell countes (males); mild focal hyperplasia and vacuolization of the epithelium lining bronchi and bronchioles of the lungs (males and females). Organ weight and hematologic changes, however, were not accompanied by any observed histologic changes. Body weights were not adversely affected by exposure. These data suggest that mild tissue injury, restricted to the lung, and methemoglobinemia are the major toxic effects observed following exposures of mice to IBN at concentrations up to 300 ppm for 18 wk. No treatment-related effects were noted in mice exposed at 20 or 50 ppm IBN, except for slight elevations in methemoglobin concentrations in mice exposed at 55 ppm.
JF  - Journal of Toxicology and Environmental Health
AU  - Lynch, D W
AU  - Moorman, W J
AU  - Burg, J R
AU  - Phipps, F C
AU  - Lewis, T R
AU  - Khan, A
AD  - NIOSH C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 823
EP  - 833
VL  - 15
IS  - 6
SN  - 0093-4108, 0093-4108
KW  - effects on
KW  - pathology
KW  - isobutyl nitrite
KW  - mice
KW  - Toxicology Abstracts
KW  - inhalation
KW  - hematology
KW  - body weight
KW  - X 24115:Pathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - inhalation; body weight; hematology
ER  - 



TY  - JOUR
T1  - Neurobehavioral tests used in NIOSH-supported worksite studies 1973-1983.
AN  - 14254734; 1079221
AB  - Between 1973 and 1983, the National Institude for Occupational Safety and Health (NIOSH) published 11 studies which reported the neurobehavioral effects of chronic exposures to industrial chemicals among working groups. This paper reviews the objectives, testing methods, findings and conclusions of these studies. The studies employed a single rationale for selecting tests-tests sensitive to the types of effects reported for the chemical under study were utilized in each case. As a result, different sets of tests were used for different studies. This strategy is distinct from the approach suggested in the other reports in these proceedings which advocate the use of a uniform test battery.
JF  - . no. 68. 1985.
AU  - Anger, W K
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
IS  - 68
KW  - behavior
KW  - tests
KW  - man
KW  - Toxicology Abstracts; CSA Neurosciences Abstracts
KW  - reviews
KW  - neurotoxicity
KW  - X 24221:Toxicity testing
KW  - X 24152:Chronic exposure
KW  - N3 11139:Toxicological and psychoactive drug correlates
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14254734?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Anger%2C+W+K&rft.aulast=Anger&rft.aufirst=W&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Neurobehavioral+tests+used+in+NIOSH-supported+worksite+studies+1973-1983.&rft.title=Neurobehavioral+tests+used+in+NIOSH-supported+worksite+studies+1973-1983.&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - neurotoxicity; reviews
ER  - 



TY  - JOUR
T1  - Experimental design of bioassays for screening and low dose extrapolation.
AN  - 14234793; 1068363
AB  - Relatively high doses of chemicals generally are employed in animal bioassays to detect potential carcinogens with relatively small numbers of animals. The problem investigated here is the development of experimental designs which are effective for high to low dose extrapolation for tumor incidence as well as for screening carcinogens.
JF  - Risk Analysis
AU  - Gaylor, D W
AU  - Chen, J J
AU  - Kodell, R L
AD  - Natl. Cent. Toxicol. Res., U.S. F.D.A., Jefferson, AR 72079, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 9
EP  - 16
VL  - 5
IS  - 1
SN  - 0272-4332, 0272-4332
KW  - dose-response effects
KW  - dose response effects
KW  - laboratory methods
KW  - Toxicology Abstracts; Health & Safety Science Abstracts
KW  - carcinogenicity
KW  - bioassays
KW  - chemicals
KW  - carcinogenesis
KW  - X 24221:Toxicity testing
KW  - H SM10.21:CANCER
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14234793?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - bioassays; carcinogenesis; chemicals; laboratory methods; carcinogenicity
ER  - 



TY  - JOUR
T1  - Spirometry reference values for nonexposed blue-collar workers.
AN  - 14231728; 1048552
AB  - Epidemiologic research into occupationally related lung disease often requires the comparison of a study population with an external reference group. To establish such a reference group, carefully selected blue-collar workers who had no obvious adverse occupational pulmonary exposure performed simple spirometry, were administered a standard questionnaire, and had standard chest roentgenograms taken. Prediction equations were established for six pulmonary function indices, and a method is given for using these equations to compare a study group with this external nonexposed group. Asymptomatic nonsmokers with negative roentgenograms were extracted from the overall group, and comparison with published data for other such normal groups indicated that the present group is similar to most of them, indicating that there are no serious biases in the present group.
JF  - J. OCCUP. MED.
AU  - Peterson, M
AU  - Hankinson, J
AD  - NIOSH, Div. Respir. Dis. Stud., 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 644
EP  - 650
VL  - 27
IS  - 9
SN  - 0096-1736, 0096-1736
KW  - X-ray radiation
KW  - research and development
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational health
KW  - surveys
KW  - research programs
KW  - respiratory diseases
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - H SM10.24:PULMONARY DISEASES
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14231728?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Spirometry+reference+values+for+nonexposed+blue-collar+workers.&rft.au=Peterson%2C+M%3BHankinson%2C+J&rft.aulast=Peterson&rft.aufirst=M&rft.date=1985-01-01&rft.volume=27&rft.issue=9&rft.spage=644&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - respiratory diseases; occupational health; research programs; surveys
ER  - 



TY  - JOUR
T1  - Cytogenetic studies in humans after short-term exposure to ethylene dibromide.
AN  - 14229953; 1066831
AB  - Ethylene dibromide (EDB) has been shown to increase sister chromatid exchange in animal cells in vitro, but its cytogenetic effects in humans have not been previously studied. A solution containing EDB is used in the summer months in Colorado to spray felled pine trees to kill pine beetles. The authors have assessed the frequencies of sister chromatid exchanges and chromosomal aberrations in the peripheral blood lymphocytes of 14 sprayers both before and after exposure. Workers sprayed EDB for only five to 26 days during the summer, with an average of 14 days. After adjusting for smoking and the use of prescription medicine, there was no statistically significant difference between the frequencies of either sister chromatid exchange or chromosomal aberrations before and after spraying.
JF  - J. OCCUP. MED.
AU  - Steenland, K
AU  - Carrano, A
AU  - Clapp, D
AU  - Ratcliffe, J
AU  - Ashworth, L
AU  - Meinhardt, T
AD  - NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 729
EP  - 732
VL  - 27
IS  - 10
SN  - 0096-1736, 0096-1736
KW  - man
KW  - acute exposure
KW  - ethylene dibromide
KW  - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts; Pollution Abstracts
KW  - sister chromatid exchange
KW  - occupational exposure
KW  - lymphocytes
KW  - chromosome aberrations
KW  - genetics
KW  - cytology
KW  - X 24155:Biochemistry
KW  - N 14920:Chromatin & chromosomes
KW  - G 07221:Specific chemicals
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Cytogenetic+studies+in+humans+after+short-term+exposure+to+ethylene+dibromide.&rft.au=Steenland%2C+K%3BCarrano%2C+A%3BClapp%2C+D%3BRatcliffe%2C+J%3BAshworth%2C+L%3BMeinhardt%2C+T&rft.aulast=Steenland&rft.aufirst=K&rft.date=1985-01-01&rft.volume=27&rft.issue=10&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cytology; genetics; sister chromatid exchange; chromosome aberrations; occupational exposure; lymphocytes
ER  - 



TY  - PAT
T1  - Hepatitis B core antigen vaccine.
AN  - 14228245; 1037708
AB  - A patent is described for the isolation of hepatitis B core antigen from the liver of an infected chimpanzee and combing it with a suitable adjuvant for the production of a vaccine.
AU  - Tabor, E
AU  - Gerety, R J
PY  - 1985
IS  - US Patent 4,547,367
KW  - hepatitis B core antigen
KW  - hepatitis B virus
KW  - patents
KW  - vaccines
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts
KW  - W 30409:Vaccines
KW  - A 01097:Viruses
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Hepatitis+B+core+antigen+vaccine.&rft.au=Tabor%2C+E%3BGerety%2C+R+J&rft.aulast=Tabor&rft.aufirst=E&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 424/89; Int. Cl. A61K 39/29.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Leukemia risk among U.S. white male coal miners.
AN  - 14226765; 1048492
AB  - The relevance of occupational exposure to electrical and magnetic fields (EMF) in the etiology of leukemia has been raised in several studies. Underground coal miners represent an occupational group with situationally determined EMF exposure, as high-voltage power distribution lines are strung overhead in the mines and converters and step down transformers provide power to mining equipment. Risk in occupational exposure to EMF was examined in a case-control study of 40 leukemia decedents and 160 control subjects who died of causes other than cancer or accident and who were matched on age at death.
JF  - J. OCCUP. MED.
AU  - Gilman, P A
AU  - Ames, R G
AU  - McCawley, MA
AD  - NIOSH, Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 669
EP  - 671
VL  - 27
IS  - 9
SN  - 0096-1736, 0096-1736
KW  - magnetic fields
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - mining
KW  - etiology
KW  - occupational health
KW  - coal
KW  - leukemia
KW  - electric fields
KW  - H SM10.27:LEUKEMIA
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14226765?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+OCCUP.+MED.&rft.atitle=Leukemia+risk+among+U.S.+white+male+coal+miners.&rft.au=Gilman%2C+P+A%3BAmes%2C+R+G%3BMcCawley%2C+MA&rft.aulast=Gilman&rft.aufirst=P&rft.date=1985-01-01&rft.volume=27&rft.issue=9&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=J.+OCCUP.+MED.&rft.issn=00961736&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - leukemia; coal; mining; occupational health; etiology; electric fields
ER  - 



TY  - PAT
T1  - Hepatitis B core antigen vaccine made by recombinant DNA.
AN  - 14226508; 1037718
AB  - This patent describes the production of a hepatitis B core antigen containing vaccine using a recombinant hepatitis B virus. The vaccine was tested on a chimpanzee model.
AU  - Tabor, E
AU  - Gerety, R J
PY  - 1985
IS  - US Patent 4,547,368
KW  - recombinants
KW  - hepatitis B core antigen
KW  - hepatitis B virus
KW  - patents
KW  - vaccines
KW  - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - W 30409:Vaccines
KW  - A 01097:Viruses
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14226508?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.jtitle=&rft.atitle=Hepatitis+B+core+antigen+vaccine+made+by+recombinant+DNA.&rft.au=Tabor%2C+E%3BGerety%2C+R+J&rft.aulast=Tabor&rft.aufirst=E&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 424/89; Int. Cl. A61K 39/29.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Evaluation of the Anderson viable impactor for single stage sampling.
AN  - 14223912; 1036538
AB  - A modified use of the 6-stage Andersen viable sampler for single stage sampling is described. Although size distribution data are not obtainable with such a sampler, it has utility as a simple and convenient method for estimating the total concentration of viable airborne microorganisms. The method was compared in the field to the standard Andersen sampler and a previously described method for single plate sampling. Over a wide range of airborne fungal concentrations (10-3000 CFU/m super(3)), the modified sampler was found to be superior to the previous method and comparable to the standard Andersen sampler (in terms of both precision and accuracy), for estimating total airborne fungal concentration.
JF  - American Industrial Hygiene Association Journal
AU  - Jones, W
AU  - Morring, K
AU  - Morey, P
AU  - Sorenson, W
AD  - NIOSH, Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 294
EP  - 298
VL  - 46
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - Anderson Viable Impactor
KW  - Pollution Abstracts
KW  - air quality
KW  - particle size
KW  - fungi
KW  - sampling instruments
KW  - microorganisms
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14223912?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Evaluation+of+the+Anderson+viable+impactor+for+single+stage+sampling.&rft.au=Jones%2C+W%3BMorring%2C+K%3BMorey%2C+P%3BSorenson%2C+W&rft.aulast=Jones&rft.aufirst=W&rft.date=1985-01-01&rft.volume=46&rft.issue=5&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - microorganisms; fungi; particle size; sampling instruments; air quality
ER  - 



TY  - JOUR
T1  - Development of push-pull ventilation.
AN  - 14221417; 1037108
AB  - Push-pull ventilation (air is blown across a contaminant generation area toward an exhaust hood) can have distinct advantages over exhaust ventilation alone. It can control contaminant emission into the workplace better than exhaust only, and much less conditioned air must be exhausted so there are energy savings. This paper presents suggested push and pull flow rate for open surface tank operations such as plating. About 98% of the contaminant generated can be captured by a push-pull system using the proper flow rates.
JF  - American Industrial Hygiene Association Journal
AU  - Huebener, D J
AU  - Hughes, R T
AD  - NIOSH, Robert A. Taft Lab., Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 262
EP  - 267
VL  - 46
IS  - 5
SN  - 0002-8894, 0002-8894
KW  - exhaust emissions
KW  - Pollution Abstracts
KW  - occupational safety
KW  - ventilation
KW  - flow rates
KW  - contamination
KW  - P 0000:AIR POLLUTION
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14221417?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Development+of+push-pull+ventilation.&rft.au=Huebener%2C+D+J%3BHughes%2C+R+T&rft.aulast=Huebener&rft.aufirst=D&rft.date=1985-01-01&rft.volume=46&rft.issue=5&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - flow rates; ventilation; contamination; occupational safety
ER  - 



TY  - JOUR
T1  - Hydrogen sulfide and the probabilities of "inhalation" through a tympanic membrane defect.
AN  - 14203579; 1032022
AB  - The authors conclude that workers with tympanic membrane defects (perforated eardrums) should not be excluded form working in atmospheres containing concentrations of hydrogen sulfide (H sub(2)S). Several existing requirements and recommendations exclude workers with perforated eardrums from working in or around H sub(2)S. Such protective measures stem from the belief that H sub(2)S can enter the body through the perforation in sufficient measure to compromise the wearer's respiratory protection. However, based on calculations of anticipated leakage of H sub(2)S for a variety of eustachian tube conditions and in the absence of either medical literature or personal reports documenting H sub(2)S poisoning due to eardrum perforation, the recommendation for excluding workers with such a condition from working in or around H sub(2)S is not supported. The anatomy, physiology, and pathology of the eustachian tube are discussed, including the effect such devices as tympanomaxillary shunts might have on contaminant leakage. The National Institute for Occupational Safety and Health (NIOSH) criteria for respirator tests and sources of respirator laekage are examined and NIOSH recommendations for respiratory protection against H sub(2)S are outlined.
JF  - J. OCCUP. MED.
AU  - Ronk, R
AU  - White, M K
AD  - Div. Saf. Res., NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 337
EP  - 340
VL  - 27
IS  - 5
SN  - 0096-1736, 0096-1736
KW  - sense organ pathology
KW  - Health & Safety Science Abstracts
KW  - membranes
KW  - inhalation
KW  - hydrogen sulfide
KW  - occupational health
KW  - H SM9.25:EAR, NOSE AND THROAT INJURIES
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - hydrogen sulfide; inhalation; membranes; occupational health
ER  - 



TY  - JOUR
T1  - Psychology in health risk messages for workers.
AN  - 14202231; 1032341
AB  - The content, style, and mode of company communications directed to workers regarding job hazards and health risks are frequently based only on concerns for technical accuracy and legal liability. These considerations do not ensure worker understanding and responsiveness. The uncertainty of health threats posed by many workplace chemical and physical agents, and the delayed, insidious disorders they may portend, present formidable obstacles in this regard. This report describes guidelines that attempt to overcome these difficulties, with specific reference to printed forms of informational material. The guidelines are based on concepts from the cognitive and social psychology literature. Selected guidelines are presented and critiques are offered of samples of hazard information materials directed to workers in light of the guidelines' prescriptions. Field trials are planned as a follow-up.
JF  - J. OCCUP. MED.
AU  - Cohen, A
AU  - Colligan, MJ
AU  - Berger, P
AD  - Appl. Psychol. and Ergon. Branch, Cent. Dis. Control, NIOSH, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 543
EP  - 551
VL  - 27
IS  - 8
SN  - 0096-1736, 0096-1736
KW  - Health & Safety Science Abstracts
KW  - occupational safety
KW  - human factors
KW  - education
KW  - training
KW  - psychology
KW  - risk assessment
KW  - H SI0.10:SAFETY EDUCATION, TRAINING, COMMUNICATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational safety; human factors; training; education; psychology; risk assessment
ER  - 



TY  - JOUR
T1  - Overview of occupational safety and health guidelines for Superfund sites.
AN  - 14201754; 1031607
AB  - An overview of the NIOSH occupational safety and health guidelines for Superfund activities is presented. Critical elements are outlined for site safety plans, site surveys and monitoring plans. The gathering of accurate and adequate information to prepare a plan of action to clean up abandoned hazardous waste sites is the first step and continues throughout any Superfund activity. Major emphasis is placed on selecting personal protective equipment with consideration for preventing heat stress. Decontamination is stressed to prevent exposure of other site workers as well as off-site personnel and the public. Worker training and medical monitoring are key components in a comprehensive occupational safety and health program for hazardous waste workers.
JF  - American Industrial Hygiene Association Journal
AU  - Ferguson, J S
AU  - Martin, W F
AD  - NIOSH, Cincinnati, OH, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 175
EP  - 180
VL  - 46
IS  - 4
SN  - 0002-8894, 0002-8894
KW  - superfund
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - federal programs
KW  - occupational health
KW  - training
KW  - hazardous materials
KW  - waste treatment plants
KW  - monitoring methods
KW  - surveys
KW  - P 9000:ENVIRONMENTAL ACTION
KW  - H SE3.5:STANDARDS, LAWS, REGULATIONS, AND POLICY
KW  - P 4000:WASTE MANAGEMENT
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - surveys; occupational health; hazardous materials; monitoring methods; waste treatment plants; training; federal programs
ER  - 



TY  - JOUR
T1  - Chronic inhalation of short asbestos fibers.
AN  - 14193732; 995180
AB  - An animal inhalation study was initiated to study the chronic biological effects of inhalation of short chrysotile asbestos fibers. Rats and monkeys were exposed for 18 months, 7 hr/day, 5 days/week to a specially prepared, chrysotile asbestos aerosol. Based upon daily chamber measurements, the mean concentration of fibers in the chamber air was 1.0 mg/m super(3). By phase constrast microscopy, the number of fibers > 5 chi m in length was determined to be 0.79 fiber per cubic centimeter. No significant differences in the histochemical data were seen between the exposed and control gropus. Gross and histopathologic examination of exposed and control groups of rats indicated no compound-related lesions, including fibrosis. Open lung biopsies were performed on the chrysotile-exposed and the control monkeys 28 months after initiating exposures. Histopathologic evaluation of the lung biopsy tissue showed the presence of asbestos bodies adjacent to the terminal bronchioles of the asbestos-exposed monkeys. There was no observed fibrosis in pulmonary tissue. All monkeys are being maintained for an indefinite period and observed for signs of latent pulmonary disease.
JF  - Fundamental and Applied Toxicology
AU  - Platek, S F
AU  - Groth, D H
AU  - Ulrich, CE
AU  - Stettler, LE
AU  - Finnell
AU  - Stoll, M
AD  - Div. Biomed. and Behav. Sci., NIOSH, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 327
EP  - 340
VL  - 5
IS  - 2
SN  - 0272-0590, 0272-0590
KW  - histopathology
KW  - asbestos
KW  - rats
KW  - monkeys
KW  - Toxicology Abstracts; Pollution Abstracts
KW  - animals
KW  - inhalation
KW  - fibers
KW  - pathology
KW  - lung
KW  - aerosols
KW  - P 0000:AIR POLLUTION
KW  - X 24154:Pathology
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - inhalation; asbestos; fibers; aerosols; pathology; animals; rats; lung
ER  - 



TY  - JOUR
T1  - Effects of a two-year inhalation exposure of rats to coal dust and/or diesel exhaust on tension responses of isolated airway smooth muscle.
AN  - 14192244; 1023355
AB  - This study was performed to determine whether chronic inhalation exposure of rats to levels of coal dust (CD) and/or diesel exhaust (DE) similar to those experienced by underground miners affects the pharmacologic characteristics of the animal's airway smooth muscle. Compared with control animals, the maximal contractile responses to acetylcholine of tissues from CD-, DE-, and CD+DE-exposed animals were significantly increased; the effects of CD and DE exposure were additive. The CD+DE exposure, but not the individual treatments, resulted in a significant increase in the maximal relaxation response elicited by isoproterenol; this interaction may have resulted from the addition of, or the synergism between, the nonsignificant effects of CD and DE alone. No treatment altered the sensitivity (EC sub(50) values) of the muscles to the agonists used. The results indicate that chronic exposure to CD, DE, and CD+DE produces differential modifications in the behavior of rat airway smooth muscle.
JF  - American Journal of Respiratory and Critical Care Medicine
AU  - Fedan, J S
AU  - Frazer, D G
AU  - Moorman, W J
AU  - Attfield, MD
AU  - Franczak
AU  - Kosten, C J
AU  - Cahill, J F
AU  - Lewis, T R
AU  - Green, FHY
AD  - Physiol. Sect., ALOSH-NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 651
EP  - 655
VL  - 131
IS  - 4
SN  - 0003-0805, 0003-0805
KW  - effects on
KW  - coal dust
KW  - diesel
KW  - contractility
KW  - smooth muscle
KW  - rats
KW  - exhaust emissions
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - exhausts
KW  - lung
KW  - coal
KW  - dust
KW  - P 0000:AIR POLLUTION
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - X 24152:Chronic exposure
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - exhausts; lung; rats; exhaust emissions; coal; dust; coal dust; contractility; smooth muscle
ER  - 



TY  - JOUR
T1  - Congenital anomalies and paternal occupational exposure to shortwave, microwave, infrared, and acoustic radiation.
AN  - 14187252; 995482
AB  - The results of an exploratory analysis of the relationship of paternal occupational exposure to nonionizing radiation and congenital anomalies in offspring are described. The study is based on data collected for a larger retrospective mail survey of potential health effects of occupational exposure to radiofrequency/microwave and other energy on male physical therapists and their offspring. An earlier report has described specific findings for the physical therapists themselves.
JF  - J. OCCUP. MED.
AU  - Logue, J N
AU  - Hamburger, S
AU  - Silverman, P M
AU  - Chiacchierini, R P
AD  - Off. Sci. and Technol., Cent. Devices and Radiol. Health, F.D.A., USDHHS, 12709 Twinbrook Pkwy. (HFZ-110), Rockville, MD 20857, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 451
EP  - 454
VL  - 27
IS  - 6
SN  - 0096-1736, 0096-1736
KW  - congenital defects
KW  - surveys
KW  - teratogenicity
KW  - microwaves
KW  - data collection
KW  - man
KW  - I.R. radiation
KW  - Toxicology Abstracts; Pollution Abstracts
KW  - radiation
KW  - microwave radiation
KW  - occupational exposure
KW  - X 24210:Radiation & radioactive materials
KW  - P 8000:RADIATION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational exposure; data collection; radiation; microwave radiation; man; I.R. radiation
ER  - 



TY  - JOUR
T1  - Cigarette smoking and inorganic dust in human lungs.
AN  - 14183368; 995595
AB  - Whole left lungs from 18 smokers and 16 nonsmokers were obtained at autopsy and studied to determine the severity of subclinical emphysema and elemental dust loads of aluminum and silicon. Whole lung Gough sections were studied and emphysema was graded on a 0 to 100 score. Concentrations of aluminum and silicon were determined in homogenized-lyophilized lung of all 34 cases by plasma emission spectrometry. In addition, histological sections from 9 pairs of age-matched smokers and nonsmokers were studied by light microscopy and scanning electron microscopy in concert with semiquantitative x-ray spectrometric analysis of aluminum and silicon content in specific anatomical regions. The results of these studies indicate that aluminum and silicon concentrations increase in smokers with increased cigarette smoking. As expected, severity of pulmonary emphysema was associated with heavy cigarette smoking.
JF  - Archives of Environmental Health
AU  - Vallyathan, V
AU  - Hahn, L H
AD  - Pathol. Sect., Lab. Invest. Branch, NIOSH, Morgantown, WV 26505, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 69
EP  - 73
VL  - 40
IS  - 2
SN  - 0003-9896, 0003-9896
KW  - aluminum
KW  - chronic exposure
KW  - association
KW  - levels
KW  - silicon
KW  - cigarette smoke
KW  - man
KW  - emphysema
KW  - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - histology
KW  - smoke
KW  - cigarettes
KW  - lung
KW  - dust
KW  - spectroscopy
KW  - H SE4.26:DRUGS AND ALCOHOL
KW  - H SM9.8.7:DUST
KW  - X 24180:Social poisons & drug abuse
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - cigarettes; dust; lung; histology; spectroscopy; smoke; silicon; cigarette smoke; man; emphysema
ER  - 



TY  - JOUR
T1  - A retrospective cohort mortality study of a phosphate fertilizer production facility.
AN  - 14181293; 995621
AB  - A retrospective cohort mortality study of phosphate fertilizer production workers was undertaken to determine whether this group is at increased risk of dying from any cause, particularly from lung cancer. A total of 3,199 workers who had ever been employed at one facility were included in this investigation. Overall, no statistically significant elevations in cause-specific mortality were observed for the entire study population. However, a statistically significant excess in lung cancer mortality was observed among workers with more than 10 yr of employment and follow-up. The findings should be viewed as suggestive, and that other investigations in plants with similar exposures are needed to clarify whether an occupationally related lung cancer excess truly exists.
JF  - Archives of Environmental Health
AU  - Stayner, L T
AU  - Meinhardt, T
AU  - Lemen, R
AU  - Bayliss, D
AU  - Herrick, R
AU  - Reeve, G R
AU  - Smith, AB
AU  - Halperin, W
AD  - Epidemiol. 2 Sect., Industrywide Stud. Branch, CDC, NIOSH, Robert A. Taft Lab., 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 133
EP  - 138
VL  - 40
IS  - 3
SN  - 0003-9896, 0003-9896
KW  - occupational health
KW  - phosphates
KW  - man
KW  - carcinoma
KW  - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - fertilizers
KW  - occupational exposure
KW  - statistical analysis
KW  - mortality
KW  - cancer
KW  - H SI6.8.2:CHEMICALS (CORROSION)
KW  - X 24132:Chronic exposure
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - mortality; fertilizers; occupational health; statistical analysis; cancer; phosphates; occupational exposure; man; carcinoma
ER  - 



TY  - JOUR
T1  - Renal toxicity in uranium mill workers.
AN  - 14177200; 995716
AB  - The present investigation evaluated kidney function among 39 uranium mill workers and 36 local cement plant workers of equivalent age, sex, and race. The uranium workers showed a significantly higher excretion of beta-2-microglobulin and five amino acids than the reference group. Although the levels of tubular proteinuria were mild, a dose-effect relation existed between the clearance of beta-2-microglobulin relative to that of creatinine, and the length of time that the uranium workers had spent in the yellowcake drying and packaging area, the work area with the highest exposures to soluble uranium. Age did not acount for this relationship. Glomerular function was significantly better among the uranium workers than among the referents, though this may have been the result of differences in the physical activity of the groups during the collection period. The data presented suggest reduced renal proximal tubular reabsorption of amino acids and of low molecular weight proteins, consistent with uranium nephrotoxicity.
JF  - Scandinavian Journal of Work, Environment & Health
AU  - Thun, MJ
AU  - Baker, D B
AU  - Steenland, K
AU  - Smith, AB
AU  - Halperin, W
AU  - Berl, T
AD  - NIOSH, R-16, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 83
EP  - 90
VL  - 11
IS  - 2
SN  - 0355-3140, 0355-3140
KW  - uranium
KW  - occupational health
KW  - kidneys
KW  - man
KW  - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - toxicity
KW  - occupational exposure
KW  - kidney
KW  - X 24164:Pathology
KW  - H SI2.9.1:RADIATION HAZARDS
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - toxicity; uranium; occupational health; kidney; occupational exposure; man
ER  - 



TY  - JOUR
T1  - The urine mutagenicity assay system. Studies related to recovery, storage and concentration procecures.
AN  - 14150404; 963104
AB  - Studies were conducted to determine (i) the effect of storage on the mutagenic activity of urine spiked with known mutagens, (ii) the efficiency of XAD-2 column on the recovery of complex mixtures from spiked urine samples, and (iii) whether the addition of XAD-7 resin to the column and/or the addition of methylene chloride to the elution process increases the recovery of mutagens from urine samples spiked with complex mixtures. Chemically spiked or nonspiked urine samples were concentrated with XAD resin and were tested for mutagenic activity with the Ames Salmonella / microsome assay system. The results indicate that the mutagenic activity of chemically spiked urine remains essentially unchanged after 7 d, but it decreases by approximately 50% for some compounds after 28 d of storage at -70 degree C.
JF  - Scandinavian Journal of Work, Environment & Health
AU  - Ong, T M
AU  - Stockhausen, A
AU  - Adamo, D
AU  - Whong, W Z
AD  - NIOSH, 944 Chestnut Ridge Rd., Morgantown, WV 26505-2888, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 45
EP  - 50
VL  - 11
IS  - 1
SN  - 0355-3140, 0355-3140
KW  - Toxicology Abstracts; Genetics Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - mutagenicity
KW  - urine
KW  - mutagens
KW  - Ames test
KW  - assays
KW  - Salmonella
KW  - storage
KW  - G 07220:General theory/testing systems
KW  - H SE4.20:POISONS AND POISONING
KW  - X 24221:Toxicity testing
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - Salmonella; mutagens; assays; urine; storage; Ames test; mutagenicity
ER  - 



TY  - PAT
T1  - Isolation of hepatitis A virus strain HM-175.
AN  - 14144473; 967542
AB  - A patent is described for the direct isolation of HAV from stool samples by passaging them through African Green Monkey kidney cells and then performing a radioimmunoassay for the detection of the virus.
AU  - Daemer, R J
AU  - Feinstone, S M
AU  - Gust, I D
AU  - Purcell, R H
PY  - 1985
IS  - US Patent 4,532,215
KW  - cell culture
KW  - monkeys
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - hepatitis A virus
KW  - patents
KW  - A 01114:Viruses
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 435/237; Int. Cl. A61K 39/29.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Reaction of dissolved chlorine with surficial sediment: Oxidant demand and production of trihalomethanes.
AN  - 14108905; 925765
AB  - Reactions between dissolved HOCl and surficial sediments from the Potomac River, MD, are reported. All sediment samples showed a tendency to react with HOCl demand was approximately 0.07 mol of HOCl/mol of adsorbed organic carbon. The only purgeable organic compounds produced by the chlorination of these sediments were trihalomethanes. The speciation and yield of trihalomethanes were found to be a sensitive function of salinity. Along the salinity gradient 0-30ppt. at pH 7.0, trihalomethane production reached a maximum at about 5ppt. salinity and then rapidly fell off with increasing salinity. It is proposed that increasing salinity alters the reactivity of adsorbed organic matter, resulting in a less reactive material at high salinities.
JF  - Environmental Science and Technology
AU  - Uhler, AD
AU  - Means, J C
AD  - Div. Chem. Technol., FDA, Washington, DC 20204, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 340
EP  - 344
VL  - 19
IS  - 4
SN  - 0013-936X, 0013-936X
KW  - hypochlorous acid
KW  - oxidants
KW  - pH effects
KW  - redox reactions
KW  - salinity effects
KW  - trihalomethanes
KW  - ASFA 2: Ocean Technology Policy & Non-Living Resources; Pollution Abstracts
KW  - chlorine
KW  - Freshwater
KW  - salinity
KW  - USA, Maryland, Potomac R.
KW  - sediments
KW  - pH
KW  - Q2 09187:Geochemistry of sediments
KW  - P 1000:MARINE POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2014-05-05
N1  - SubjectsTermNotLitGenreText - chlorine; salinity effects; redox reactions; sediments; salinity; pH effects; pH; oxidants; USA, Maryland, Potomac R.; Freshwater
ER  - 



TY  - PAT
T1  - Inactivation of a lipid virus.
AN  - 14084379; 906236
AB  - A patent is described on a method of inactivating viruses that contain essential lipids in a blood plasma product which comprises contacting said product with a least one halohydrocarbon treating agent selected from the group consisting of chloroform and a freon.
AU  - Purcell, R H
AU  - Feinstone, S M
PY  - 1985
IS  - US Patent 4,511,556
KW  - methodology
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - inactivation
KW  - viruses
KW  - patents
KW  - A 01113:General
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 514/743; Int. Cl. A61K 35/14, A61K 39/12, A61K 31/02, C12N 7/06.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Notification of a cohort of workers at risk of bladder cancer.
AN  - 14054904; 881176
AB  - Surviving members of occupational cohorts studied in retrospective analyses of mortality usually are not notified individually of positive study results. However, concern has arisen that such results may contain risk information pertinent to study subjects. To evaluate the effects and implications of individually notifying survivors of such cohorts, the authors conducted a pilot notification study. Members of a cohort of 1,385 chemical workers who had handled carcinogenic amines were notified by mail that they were likely to be at increased risk of bladder cancer. Also a bladder cancer screening and follow-up program was established. The study demonstrated that notification is a complex action and that much care needs to be taken when communicating information on risk. Notification requires development of (1) criteria as to what constitutes a notifiable risk and (2) programs to meet the medical and social needs of the various parties involved in notification.
JF  - J. OCCUP. MED.
AU  - Schulte, P A
AU  - Ringen, K
AU  - Altekruse, E B
AU  - Gullen, W H
AU  - Davidson, K
AU  - Anderson, S S
AU  - Patton, M G
AD  - NIOSH, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 19
EP  - 28
VL  - 27
IS  - 1
SN  - 0096-1736, 0096-1736
KW  - chemical industry
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - occupational health
KW  - mortality
KW  - risk assessment
KW  - cancer
KW  - H SI6.8.2:CHEMICALS (CORROSION)
KW  - H SM10.21:CANCER
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - Last updated - 2011-12-12
N1  - SubjectsTermNotLitGenreText - occupational health; cancer; risk assessment; mortality
ER  - 



TY  - PAT
T1  - Method for obtaining periplasmic proteins from bacterial cells using chloroform.
AN  - 14043128; 865133
AB  - A method is described for extracting periplasmic protein without homogenizing the cellular suspension by use of chloroform as an organic solvent.
AU  - Ames, G F
AU  - Kustu, S G
PY  - 1985
IS  - US Patent 4,497,730
KW  - isolation
KW  - methodology
KW  - solvents
KW  - chloroform
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - periplasmic space
KW  - bacteria
KW  - proteins
KW  - patents
KW  - A 01116:Bacteria
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2006-11-01
N1  - SuppNotes - US Cl. 260/112 R; Int. Cl. C07G 7/00, A23J 1/18.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - A survey of 2,3,7,8-TCDD residues in fish from the Great Lakes and selected Michigan rivers
AN  - 13831299; 198504517
AB  - Details are given of methodology used to determine residues of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish species collected from 48 sampling stations in the Great Lakes and 15 rivers in Michigan. A map showing the sampling sites is included. TCDD was determined by capillary gas chromatography with electron capture detection and confirmed by high-resolution gas chromatography with mass spectrometry using multiple ion detection of 12 ions. The highest levels of contamination were found in fish from Saginaw bay on Huron lake, the Tittabawassee river, Michigan, and Ontario lake.
JF  - Chemosphere
AU  - Fehringer, N V
AU  - Walters, S M
AU  - Ayers, R J
AU  - Kozara, R J
AU  - Ogger, J D
AU  - Schneider, L F
AD  - U.S. Food and Drug Administration, Detroit, Mich.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 909
EP  - 912
VL  - 14
IS  - 6/7
SN  - 0045-6535, 0045-6535
KW  - Tetrachlorodibenzo-p-dioxin
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Case Study.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - The use of a short cleanup followed by GC/ECD analysis for octachlorodibenzo-p-dioxin as a screening method for samples obtained from a PCDD and PCDF contaminated site
AN  - 13830285; 198504516
AB  - In view of growing concern about environmental contamination with polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF), chemical analysis of samples containing these compounds was important. The analytical techniques used must be selective and very sensitive, because of the high toxicity of many of these compounds. Most methods that had been employed were long and difficult. A simplified method was developed involving a short clean-up of the sample followed by determination of octachlorodibenzo-p-dioxin using fused silica capillary gas chromatography with electron capture detection. This technique was suitable as a routine screening procedure for samples taken from a site known to be contaminated with PCDD and PCDF.
JF  - Chemosphere
AU  - Korfmacher, WA
AU  - Rushing, L G
AU  - Nestorick, D M
AU  - Thompson, H C
AU  - Mitchum, R K
AU  - Kominsky, J R
AD  - National Center for Toxicological Research, Jefferson, Ariz.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 847
EP  - 850
VL  - 14
IS  - 6/7
SN  - 0045-6535, 0045-6535
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Application.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Deactivation of hazardous chemical wastes
AN  - 13827582; 198502336
AB  - Giving a bibliography of 48 references, the authors review various techniques for the treatment and disposal of hazardous wastes, including chemical conversion, removal of hazardous constituents, and stabilization or fixation. The different processes available under each heading, and the types of waste to which they are applicable, are summarized in tables.
JF  - Environmental Science & Technology
AU  - Tucker, S P
AU  - Carson, G A
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 215
EP  - 220
VL  - 19
IS  - 3
SN  - 0013-936X, 0013-936X
KW  - Aqualine Abstracts
KW  - AQ 00007:Industrial Effluents
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - An overview of environmental and toxicological aspects of aromatic hydrocarbons. II: toluene
AN  - 13825660; S198618987
AB  - Information on the production and use of toluene, emission sources, exposure levels, populations at risk, toxicology, including uptake and elimination, effects in humans and animals and genetic effects are reviewed. The narcotic and neurotoxic properties of toluene represented the principal health hazard to humans. A bibliography of 107 references is appended.
JF  - Science of the Total Environment
AU  - Fishbein, L
AD  - National Center for Toxicological Research, Jefferson, Ariz.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 267
EP  - 288
VL  - 42
IS  - 3
SN  - 0048-9697, 0048-9697
KW  - Animals (see also individual groups below)
KW  - Hazard
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Survey of 2,3,7,8-tetrachlorodibenzo-p-dioxin in fish from the Great Lakes and selected Michigan rivers
AN  - 13816314; 198602844
AB  - Skinless fillets of fish were analysed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) residues using combinations and modifications of published methods. Detection limits, using high resolution gas chromatography with electron capture (HRGC-EC) followed by HRGC-MS, were about 10 ppt TCDD. The fish were collected during surveys of Saginaw bay (Huron lake) in 1979, 1981, 1983 surveys of eastern Erie lake (1981, 1983), and the Great Lakes National Program surveys (1983). Analytical results showed highest levels of TCDD contamination in Saginaw bay, Ontario lake, and the Tittabawassee river. Concentrations ranged from 16 ppt in a Saginaw bay carp to 102 ppt in a Saginaw bay catfish. No TCDD residues were detected in Michigan rivers other than the Tittabawassee.
JF  - Journal of Agricultural and Food Chemistry
AU  - Fehringer, N V
AU  - Walters, S M
AU  - Kozara, R J
AU  - Schneider, L F
AD  - FDA, Detroit, Mich.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 626
EP  - 630
VL  - 33
IS  - 4
SN  - 0021-8561, 0021-8561
KW  - Analysis
KW  - Fish (see also individual groups listed below)
KW  - Tetrachlorodibenzo-p-dioxin
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - An overview of environmental and toxicological aspects of aromatic hydrocarbons: IV. Ethylbenzene
AN  - 13807554; S198721102
AB  - The production and use, emission sources, chemical and photochemical reactions, and susceptibility to microbial oxidation of ethylbenzene is reviewed. Exposure levels and at-risk populations are discussed. The section on toxicology covers uptake and elimination, effects on humans and animals, and genetic, embryotoxic and teratogenic effects. Occupational exposure to ethylbenzene occurred during its production and subsequent conversion into styrene, and during the production and use of mixed xylenes. The general public was exposed to ethylbenzene in motor vehicle exhaust and cigarette smoke. Inhalation was the principal absorption route. Ethylbenzene was primarily a skin irritant, but also affected mucous membranes and had narcotic properties at high concentrations. An oral dose of 3.5 g per kg was reported to be acutely lethal in rats.
JF  - Science of the Total Environment
AU  - Fishbein, L
AD  - Food and Drug Administration, Jefferson, Ark.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 269
EP  - 287
VL  - 44
IS  - 3
SN  - 0048-9697, 0048-9697
KW  - Animals (see also individual groups below)
KW  - Ethylbenzene
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1978-September 1979
AN  - 13804632; S198823841
AB  - Dietary intake of selected pesticides, industrial chemicals and elements (arsenic, cadmium, lead, mercury, selenium and zinc) by infants (6 months old) and toddlers (2 years old) were studied. Food was purchased from retailers in 10 cities. Drinking water was one of the 11 food groups. Tables show average concentration, range of concentrations, average daily intake and daily intake per unit of body weight for the contaminants studied. Dietary intakes were similar to previous years and generally within acceptable limits. Tris(2-chlorethyl)phosphate was found in one drinking water sample.
JF  - Journal of Association of Official Analytical Chemists
AU  - Gartrell, MJ
AU  - Craun, J C
AU  - Podrebarac, D S
AU  - Gunderson, EL
AD  - Food and Drug Administration, Washington, D.C.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 842
EP  - 861
VL  - 68
IS  - 5
KW  - Pb
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Case Study.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1979-September 1980
AN  - 13804433; S198823959
AB  - Dietary intake of selected pesticides, industrial chemicals and elements (arsenic, cadmium, lead, mercury, selenium and zinc) by infants (6 months old) and toddlers (2 years old) was studied. Food was purchased from retailers in 10 cities. Drinking water was one of the 11 food groups. Tables show average concentration, range of concentrations, average daily intake and daily intake per unit of body weight for the contaminants studied. Dietary intakes were similar to previous years and generally within acceptable limits. No chemicals or residues were detected in drinking water.
JF  - Journal of Association of Official Analytical Chemists
AU  - Gartrell, MJ
AU  - Craun, J C
AU  - Podrebarac, D S
AU  - Gunderson, EL
AD  - Food and Drug Administration, Washington, D.C.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 1163
EP  - 1183
VL  - 68
IS  - 6
KW  - Pb
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1980-March 1982
AN  - 13803995; S198823961
AB  - Dietary intake of selected pesticides, industrial chemicals and elements (arsenic, cadmium, lead, mercury, selenium and zinc) by infants (6 months old) and toddlers (2 years old) was studied. Food was purchased from retailers in 13 cities. Drinking water was one of the 11 food groups. Tables show average concentration, range of concentrations, average daily intake and daily intake per unit of body weight for the contaminants studied. Dietary intakes were similar to previous years and generally within acceptable limits. No chemicals or residues were detected in drinking water.
JF  - Journal of Association of Official Analytical Chemists
AU  - Gartrell, MJ
AU  - Craun, J C
AU  - Podrebarac, D S
AU  - Gunderson, EL
AD  - Food and Drug Administration, Washington, D.C.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 123
EP  - 145
VL  - 69
IS  - 1
KW  - Pb
KW  - Aqualine Abstracts
KW  - AQ 00002:Water Quality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  - 



TY  - JOUR
T1  - Fungal metabolism and detoxification of polycyclic aromatic hydrocarbons
AN  - 13797090; S198824501
AB  - Cunninghamella elegans was incubated at 25C for 72 h in the presence of naphthalene, anthracene, phenanthrene, benz(a)anthracene, 7,12-dimethylbenz(a)anthracene, 3-methylcholanthrene, and benzo(a)pyrene. Ethyl acetate extracts of the incubation were dried and concentrated under reduced pressure at 40C. The residue of PAH was dissolved in methanol and analysed for metabolism by high performance liquid chromatography. Mutagenicity assays were performed using Salmonella typhimurium tester strains TA98 and TA100 both with and without metabolic activation using a liver fraction from Arochlor 1254 treated rats. No extract from the fungal incubations showed mutagenic activity. Kinetic experiments on the metabolism of benzo(a)pyrene and 7,12-dimethylbenz(a)-anthracene by C. elegans were used to determine the mutagenic activity of the extracts at various time intervals. An increased time of fungal incubation decreased the mutagenicity of the extract from cultures. This was accompanied by a corresponding increase in the metabolism of the PAH. C. elegans detoxified known carcinogens and mutagens and it was suggested that the fungus might metabolise and inactivate PAH in the environment.
JF  - Archives of Microbiology
AU  - Cerniglia, CE
AU  - White, G L
AU  - Heflich, R H
AD  - Food and Drug Administration, Jefferson, Ariz.
Y1  - 1985
PY  - 1985
DA  - 1985
SP  - 105
EP  - 110
VL  - 143
IS  - 2
SN  - 0302-8933, 0302-8933
KW  - Anthracene
KW  - Reduction
KW  - Ethylacetate
KW  - Methylcholanthrene
KW  - Analysis
KW  - Aqualine Abstracts
KW  - AQ 00003:Monitoring and Analysis of Water and Wastes
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2000-09-01
N1  - SuppNotes - Publication focus: Experimental.
N1  - Last updated - 2011-12-12
ER  -