TY - CPAPER T1 - Seafood toxins: Outbreaks, research, and management AN - 42292447; 3186493 AU - Hall, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42292447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Seafood+toxins%3A+Outbreaks%2C+research%2C+and+management&rft.au=Hall%2C+S&rft.aulast=Hall&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: USAMRID, Toxinology Division, Fort Detrick, MD 21702, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analytical measurements of ciguatoxin levels in fish tissue using mass spectrometry AN - 42290353; 3186490 AU - Musser, S M AU - Granade, H R AU - Dickey, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42290353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analytical+measurements+of+ciguatoxin+levels+in+fish+tissue+using+mass+spectrometry&rft.au=Musser%2C+S+M%3BGranade%2C+H+R%3BDickey%2C+R+W&rft.aulast=Musser&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: USAMRID, Toxinology Division, Fort Detrick, MD 21702, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New U.S. GMP - Implementation procedures AN - 42267257; 3169282 AU - Trautman, KA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42267257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+U.S.+GMP+-+Implementation+procedures&rft.au=Trautman%2C+KA&rft.aulast=Trautman&rft.aufirst=KA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Medical Instrumentation, 3330 Washington Blvd., Suite 400, Arlington, VA 22201, Abstracts available. Price $25. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IEC 601-1-2: Advantages, disadvantages, and future amendments AN - 42263262; 3169402 AU - Silberberg, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42263262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IEC+601-1-2%3A+Advantages%2C+disadvantages%2C+and+future+amendments&rft.au=Silberberg%2C+J&rft.aulast=Silberberg&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Medical Instrumentation, 3330 Washington Blvd., Suite 400, Arlington, VA 22201, Abstracts available. Price $25. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health benefits of Asian vegetarian foods AN - 42262971; 3172657 AU - Ang, CYW AU - Hang, Y D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42262971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Health+benefits+of+Asian+vegetarian+foods&rft.au=Ang%2C+CYW%3BHang%2C+Y+D&rft.aulast=Ang&rft.aufirst=CYW&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute of Food Technologists, Customer Service Dept., 221 N. LaSalle, Suite #300, Chicago, IL 60601, Abstracts available. Price $25 in U.S. and Canada; $50 elsewhere. Paper No. 71-3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microbiological concerns about modified atmosphere packaged (MAP) produce AN - 42256932; 3172820 AU - Rhodehamel, E J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42256932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microbiological+concerns+about+modified+atmosphere+packaged+%28MAP%29+produce&rft.au=Rhodehamel%2C+E+J&rft.aulast=Rhodehamel&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute of Food Technologists, Customer Service Dept., 221 N. LaSalle, Suite #300, Chicago, IL 60601, Abstracts available. Price $25 in U.S. and Canada; $50 elsewhere. Paper No. 83-6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunophenotyping of normal human worker volunteers: Distribution and range studies AN - 42243432; 3142828 AU - Biagini, R E AU - Pinkerton, LE AU - Johanning, E AU - Hull, R D AU - Ward, E M AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42243432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunophenotyping+of+normal+human+worker+volunteers%3A+Distribution+and+range+studies&rft.au=Biagini%2C+R+E%3BPinkerton%2C+LE%3BJohanning%2C+E%3BHull%2C+R+D%3BWard%2C+E+M%3BLuster%2C+MI&rft.aulast=Biagini&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 1209 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro cytotoxicity of fiberglass samples: Importance of physical properties AN - 42235162; 3141852 AU - Castranova, V AU - Pailes, W H AU - Judy, D J AU - Schwegler-Berry, D AU - Jones, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42235162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+cytotoxicity+of+fiberglass+samples%3A+Importance+of+physical+properties&rft.au=Castranova%2C+V%3BPailes%2C+W+H%3BJudy%2C+D+J%3BSchwegler-Berry%2C+D%3BJones%2C+W&rft.aulast=Castranova&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Paper No. 246 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biologically-based, quantitative risk assessment of neurotoxicants: Introduction AN - 42235122; 3141839 AU - Slikker, W Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42235122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biologically-based%2C+quantitative+risk+assessment+of+neurotoxicants%3A+Introduction&rft.au=Slikker%2C+W+Jr&rft.aulast=Slikker&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Paper No. 233 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of antimony on mitochondrial function and protein thiol and adenine nucleotide status in cultured cardiac myocytes AN - 42231536; 3143270 AU - Tirmenstein, MA AU - Wey, HE AU - Mathias, P I AU - Toraason, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42231536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+antimony+on+mitochondrial+function+and+protein+thiol+and+adenine+nucleotide+status+in+cultured+cardiac+myocytes&rft.au=Tirmenstein%2C+MA%3BWey%2C+HE%3BMathias%2C+P+I%3BToraason%2C+M&rft.aulast=Tirmenstein&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 1662 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of calcium and phospholipase in potassium antimonyl tartrate-induced cardiac myocyte toxicity AN - 42231489; 3143269 AU - Wey, H AU - Richards, D AU - Mathias, P AU - Tirmenstein, M AU - Walker, C AU - Toraason, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42231489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+calcium+and+phospholipase+in+potassium+antimonyl+tartrate-induced+cardiac+myocyte+toxicity&rft.au=Wey%2C+H%3BRichards%2C+D%3BMathias%2C+P%3BTirmenstein%2C+M%3BWalker%2C+C%3BToraason%2C+M&rft.aulast=Wey&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 1661 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue specific induction of hsp72 in heat treated rat embryos AN - 42228300; 3141879 AU - Fisher, B R AU - Brown, K M AU - Goering, P L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tissue+specific+induction+of+hsp72+in+heat+treated+rat+embryos&rft.au=Fisher%2C+B+R%3BBrown%2C+K+M%3BGoering%2C+P+L&rft.aulast=Fisher&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 273 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigation of hepatoprotection afforded by repeated exposure to acetaminophen AN - 42228182; 3142428 AU - Roberts, D W AU - Shayiq, R AU - Snawder, JE AU - Benson, R W AU - Ho, L L AU - Ma, X AU - Black, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Investigation+of+hepatoprotection+afforded+by+repeated+exposure+to+acetaminophen&rft.au=Roberts%2C+D+W%3BShayiq%2C+R%3BSnawder%2C+JE%3BBenson%2C+R+W%3BHo%2C+L+L%3BMa%2C+X%3BBlack%2C+M&rft.aulast=Roberts&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA software challenge AN - 42224799; 3143873 AU - Rudolph, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42224799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=FDA+software+challenge&rft.au=Rudolph%2C+H&rft.aulast=Rudolph&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for the Advancement of Science, Customer Service, 1333 H St., NW, Washington, DC 20005. Phone: (202)326-6450, Abstracts available. Price $25. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicology testing for tumor promotion AN - 42218013; 3152281 AU - Grieshaber, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Toxicology+testing+for+tumor+promotion&rft.au=Grieshaber%2C+C&rft.aulast=Grieshaber&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sample size and population pharmacokinetic studies AN - 42217904; 3152241 AU - Ette, E I AU - Sun, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42217904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sample+size+and+population+pharmacokinetic+studies&rft.au=Ette%2C+E+I%3BSun%2C+H&rft.aulast=Ette&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proposed descriptors for muscle relaxant onset and duration AN - 42217464; 3152293 AU - Bedford, R AU - Spyker, D AU - Wright, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42217464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Proposed+descriptors+for+muscle+relaxant+onset+and+duration&rft.au=Bedford%2C+R%3BSpyker%2C+D%3BWright%2C+C&rft.aulast=Bedford&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medical school teaching sites at public health agencies AN - 42216141; 3144974 AU - Melville, S K AU - Coghlin, J AU - Chen, D W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Localization+of+the+Coeur+d%27Alene+mining+district+at+the+juncture+of+the+Lewis+and+Clark+and+Noxon+lines&rft.au=White%2C+Brian+G%3BAppelgate%2C+Larry+M%3BAnonymous&rft.aulast=White&rft.aufirst=Brian&rft.date=2000-03-01&rft.volume=32&rft.issue=5&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association of Preventive Medicine, 1660 L Street, NW, Suite 206, Washington, DC 20036, Abstracts available. Price $5. Poster Paper No. PS37 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparable drug efficacy AN - 42215333; 3152289 AU - Stein, R A AU - Leung, H M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparable+drug+efficacy&rft.au=Stein%2C+R+A%3BLeung%2C+H+M&rft.aulast=Stein&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Women and special populations in Phase 1 research: FDA perspective AN - 42215313; 3152272 AU - Williams, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+strategies+for+the+evaluation+of+the+carcinogenic+activities+of+chemicals&rft.au=Schwetz%2C+BA&rft.aulast=Schwetz&rft.aufirst=BA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prenatal ultrasound and birth weight: Does the timing of first exposure affect outcome? AN - 42198764; 3135568 AU - Marinac-Dabic, D AU - Krulewitch, C J AU - Moore, RM Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prenatal+ultrasound+and+birth+weight%3A+Does+the+timing+of+first+exposure+affect+outcome%3F&rft.au=Marinac-Dabic%2C+D%3BKrulewitch%2C+C+J%3BMoore%2C+RM+Jr&rft.aulast=Marinac-Dabic&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Publication Sales, 1015 15th St., NW, Washington, DC 20005, USA, Abstracts available. Price $30 for 2-volume set. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of natural killer cells in the rauscher murine leukemia virus model: Immunomodulatory and antiviral mechanisms of 9-(2-phosphonyl-methoxyethyl)adenine AN - 42187058; 3122829 AU - Kunder, S C AU - Black, P L AU - Hall, B E AU - Ussery, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42187058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+natural+killer+cells+in+the+rauscher+murine+leukemia+virus+model%3A+Immunomodulatory+and+antiviral+mechanisms+of+9-%282-phosphonyl-methoxyethyl%29adenine&rft.au=Kunder%2C+S+C%3BBlack%2C+P+L%3BHall%2C+B+E%3BUssery%2C+MA&rft.aulast=Kunder&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Books International, PO Box 605, Herndon, VA 22070, Abstracts available. Price $25. Poster Paper No. I140 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human peripheral blood mononuclear cells labeled with the fluorescent dye PKH26 can replicate HIV-1 in vitro and in vivo in HuPBMC-SCID mice AN - 42185073; 3122828 AU - Wood, O L AU - Black, P L AU - Broud, D D AU - Ussery, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42185073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+peripheral+blood+mononuclear+cells+labeled+with+the+fluorescent+dye+PKH26+can+replicate+HIV-1+in+vitro+and+in+vivo+in+HuPBMC-SCID+mice&rft.au=Wood%2C+O+L%3BBlack%2C+P+L%3BBroud%2C+D+D%3BUssery%2C+MA&rft.aulast=Wood&rft.aufirst=O&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Books International, PO Box 605, Herndon, VA 22070, Abstracts available. Price $25. Poster Paper No. I138 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Passive immunization of mice with antiserum to capsular polysaccharide-tetanus toxoid conjugate confers protection against Vibrio vulnificus septicemia AN - 42181837; 3123186 AU - Devi, S AU - Hayat, U AU - Powell, J AU - Frasch, CE AU - Morris, JG Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42181837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Passive+immunization+of+mice+with+antiserum+to+capsular+polysaccharide-tetanus+toxoid+conjugate+confers+protection+against+Vibrio+vulnificus+septicemia&rft.au=Devi%2C+S%3BHayat%2C+U%3BPowell%2C+J%3BFrasch%2C+CE%3BMorris%2C+JG+Jr&rft.aulast=Devi&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Books International, PO Box 605, Herndon, VA 22070, Abstracts available. Price $25. Poster Paper No. G82 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food facility plan review AN - 42031311; 3116831 AU - Schrade, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42031311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Food+facility+plan+review&rft.au=Schrade%2C+J&rft.aulast=Schrade&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Association of Milk, Food and Environmental Sanitarians, 6200 Aurora Ave., Suite 200W, Des Moines, IA 50322, USA., Abstracts available. Price $10.50. Paper No. 16 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biotransformations of polyaromatic hydrocarbons AN - 42029568; 3102210 AU - Cerniglia, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42029568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biotransformations+of+polyaromatic+hydrocarbons&rft.au=Cerniglia%2C+C&rft.aulast=Cerniglia&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - International food safety and quality standards AN - 42028105; 3117017 AU - Carnevale, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42028105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=International+food+safety+and+quality+standards&rft.au=Carnevale%2C+C&rft.aulast=Carnevale&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Association of Milk, Food and Environmental Sanitarians, 6200 Aurora Ave., Suite 200W, Des Moines, IA 50322, USA., Abstracts available. Price $10.50. Paper No. 202 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Economics of federal HACCP regulations AN - 42027409; 3116911 AU - Zorn, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42027409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Economics+of+federal+HACCP+regulations&rft.au=Zorn%2C+D&rft.aulast=Zorn&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Association of Milk, Food and Environmental Sanitarians, 6200 Aurora Ave., Suite 200W, Des Moines, IA 50322, USA., Abstracts available. Price $10.50. Poster Paper No. 96 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory perspectives on the use of bacteriocins in foods AN - 42027114; 3116988 AU - Fields, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42027114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulatory+perspectives+on+the+use+of+bacteriocins+in+foods&rft.au=Fields%2C+F&rft.aulast=Fields&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Association of Milk, Food and Environmental Sanitarians, 6200 Aurora Ave., Suite 200W, Des Moines, IA 50322, USA., Abstracts available. Price $10.50. Paper No. 173 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-term survival of Vibrio cholerae O1 in seawater AN - 42026812; 3104466 AU - McCarthy, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42026812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Co-amplification+of+specific+sequences+of+HIV-1+and+HCV+genomes+by+the+polymerase+chain+reaction+assay%3A+A+potential+tool+for+the+simultaneous+detection+of+HIV-1+and+HCV&rft.au=Nedjar%2C+S%3BHewlett%2C+I%3BBiswas%2C+R&rft.aulast=Nedjar&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. Q480 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intranasal administration of filamentous hemagglutinin liposomes stimulates protective immunity against Bordetella pertussis infection AN - 42024068; 3101782 AU - Leef, M AU - Schwartz, GM Jr AU - Alving, C R AU - Shahin, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42024068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intranasal+administration+of+filamentous+hemagglutinin+liposomes+stimulates+protective+immunity+against+Bordetella+pertussis+infection&rft.au=Leef%2C+M%3BSchwartz%2C+GM+Jr%3BAlving%2C+C+R%3BShahin%2C+R+D&rft.aulast=Leef&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. E44 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic restriction pattern diversity among Vibrio vulnificus from different environments AN - 42020236; 3103503 AU - Singer, P D AU - Tall, B D AU - Khambaty, F M AU - Shah, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42020236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genomic+restriction+pattern+diversity+among+Vibrio+vulnificus+from+different+environments&rft.au=Singer%2C+P+D%3BTall%2C+B+D%3BKhambaty%2C+F+M%3BShah%2C+D+B&rft.aulast=Singer&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. C417 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - katG gene of isoniazid-resistant strains of Mycobacterium tuberculosis AN - 42017535; 3104074 AU - Rouse, D AU - Morris, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42017535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=katG+gene+of+isoniazid-resistant+strains+of+Mycobacterium+tuberculosis&rft.au=Rouse%2C+D%3BMorris%2C+S&rft.aulast=Rouse&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. U125 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - N-Oxidation of isoquinoline by the fungus Cunninghamella elegans AN - 42015390; 3103939 AU - Sutherland, J B AU - Freeman, J P AU - Williams, A J AU - Cerniglia, CE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42015390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=N-Oxidation+of+isoquinoline+by+the+fungus+Cunninghamella+elegans&rft.au=Sutherland%2C+J+B%3BFreeman%2C+J+P%3BWilliams%2C+A+J%3BCerniglia%2C+CE&rft.aulast=Sutherland&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. Q443 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stress conditions affect virulence of a rifampin-resistant mutant of Francisella tularensis AN - 42014914; 3101383 AU - Bhatnagar, LVSN AU - Elkins, K AU - Fortier, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42014914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stress+conditions+affect+virulence+of+a+rifampin-resistant+mutant+of+Francisella+tularensis&rft.au=Bhatnagar%2C+LVSN%3BElkins%2C+K%3BFortier%2C+A&rft.aulast=Bhatnagar&rft.aufirst=LVSN&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. D98 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved rapid technique for isolation of Escherichia coli O157:H7 from foods AN - 42011707; 3104284 AU - Weagant, S D AU - Bryant, J L AU - Jinneman, K G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42011707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Improved+rapid+technique+for+isolation+of+Escherichia+coli+O157%3AH7+from+foods&rft.au=Weagant%2C+S+D%3BBryant%2C+J+L%3BJinneman%2C+K+G&rft.aulast=Weagant&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Paper No. P94 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of nasal corticoid treatments in hayfever studies AN - 42010101; 3083184 AU - Harter, J G AU - Stein, R A AU - Love, P Y Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42010101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analysis+of+nasal+corticoid+treatments+in+hayfever+studies&rft.au=Harter%2C+J+G%3BStein%2C+R+A%3BLove%2C+P+Y&rft.aulast=Harter&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PII-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sulindac: Exploratory modeling and bioequivalence implications AN - 42009376; 3083117 AU - Hale, V G AU - Borga, O AU - Harter, J G AU - Katzper, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42009376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sulindac%3A+Exploratory+modeling+and+bioequivalence+implications&rft.au=Hale%2C+V+G%3BBorga%2C+O%3BHarter%2C+J+G%3BKatzper%2C+M&rft.aulast=Hale&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PI-69 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of prolonged starvation on mutation spectra AN - 42008610; 3094021 AU - Prival, MJ AU - Cebula, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42008610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+prolonged+starvation+on+mutation+spectra&rft.au=Prival%2C+MJ%3BCebula%2C+T+A&rft.aulast=Prival&rft.aufirst=MJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, 605 Third Ave., New York, NY 10158-0012 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bias (B) and efficiency (EFF) effects of correlation (CORR) between pharmacokinetics (PK) and pharmacodynamics (PD) in post-hoc concentration-effect (CE) analyses of parallel dose-response trials AN - 42006668; 3083208 AU - Peck, C AU - Ludden, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42006668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bias+%28B%29+and+efficiency+%28EFF%29+effects+of+correlation+%28CORR%29+between+pharmacokinetics+%28PK%29+and+pharmacodynamics+%28PD%29+in+post-hoc+concentration-effect+%28CE%29+analyses+of+parallel+dose-response+trials&rft.au=Peck%2C+C%3BLudden%2C+T&rft.aulast=Peck&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PII-41 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disposition of malachite green in the channel catfish AN - 42006253; 3087636 AU - Plakas, S M AU - El-Said, K R AU - Stehly, G R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42006253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Disposition+of+malachite+green+in+the+channel+catfish&rft.au=Plakas%2C+S+M%3BEl-Said%2C+K+R%3BStehly%2C+G+R&rft.aulast=Plakas&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Paper No. 1710 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of ciguatera toxin in fish using HPTLC techniques AN - 42005298; 3102072 AU - Dixon, L G AU - Hamdy, M K AU - Hayden, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42005298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+ciguatera+toxin+in+fish+using+HPTLC+techniques&rft.au=Dixon%2C+L+G%3BHamdy%2C+M+K%3BHayden%2C+MA&rft.aulast=Dixon&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. P29 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative effects of quinoline and 8-hydroxyquinoline on glutathione levels, DNA fragmentation and enzyme induction in cultured rat hepatocytes AN - 42004899; 3086630 AU - Tirmenstein, MA AU - Snawder, JE AU - Plews, P I AU - Torraason, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42004899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+effects+of+quinoline+and+8-hydroxyquinoline+on+glutathione+levels%2C+DNA+fragmentation+and+enzyme+induction+in+cultured+rat+hepatocytes&rft.au=Tirmenstein%2C+MA%3BSnawder%2C+JE%3BPlews%2C+P+I%3BTorraason%2C+M&rft.aulast=Tirmenstein&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Poster Paper No. 702 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biofilm formation in water supply lines of dental air-water syringes AN - 42003282; 3102048 AU - Gray, R T AU - Kelley, JI AU - George, K S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42003282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biofilm+formation+in+water+supply+lines+of+dental+air-water+syringes&rft.au=Gray%2C+R+T%3BKelley%2C+JI%3BGeorge%2C+K+S&rft.aulast=Gray&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. N39 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Secretion of pertussis toxin from Bordetella pertussis AN - 42003148; 3100468 AU - Burns, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42003148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Secretion+of+pertussis+toxin+from+Bordetella+pertussis&rft.au=Burns%2C+D&rft.aulast=Burns&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative developmental toxicity of urethane (URE), 2-methoxyethanol (2ME) and methotrexate (MTX) in Drosophila melanogaster obtained from two sources AN - 42002475; 3086522 AU - Lynch, D W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42002475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+developmental+toxicity+of+urethane+%28URE%29%2C+2-methoxyethanol+%282ME%29+and+methotrexate+%28MTX%29+in+Drosophila+melanogaster+obtained+from+two+sources&rft.au=Lynch%2C+D+W&rft.aulast=Lynch&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Poster Paper No. 594 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutational events at Salmonella typhimurium base-substitution alleles as predictors of eukaryotic mutational specificity AN - 42002367; 3093932 AU - Koch, W H AU - Cebula, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42002367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mutational+events+at+Salmonella+typhimurium+base-substitution+alleles+as+predictors+of+eukaryotic+mutational+specificity&rft.au=Koch%2C+W+H%3BCebula%2C+T+A&rft.aulast=Koch&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, 605 Third Ave., New York, NY 10158-0012 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence changes induced by ENNG at the Ochre locus in E. coli WU3610 AN - 42002210; 3093865 AU - Elespuru, R K AU - Tada, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42002210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sequence+changes+induced+by+ENNG+at+the+Ochre+locus+in+E.+coli+WU3610&rft.au=Elespuru%2C+R+K%3BTada%2C+M&rft.aulast=Elespuru&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, 605 Third Ave., New York, NY 10158-0012 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification, characterization, and origins of an imp operon on F' episomes carrying finp301 AN - 42001515; 3093864 AU - Eisenstadt, E AU - Henrikson, E AU - Koch, W H AU - Cebula, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42001515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification%2C+characterization%2C+and+origins+of+an+imp+operon+on+F%27+episomes+carrying+finp301&rft.au=Eisenstadt%2C+E%3BHenrikson%2C+E%3BKoch%2C+W+H%3BCebula%2C+T+A&rft.aulast=Eisenstadt&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, 605 Third Ave., New York, NY 10158-0012 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of titanium oxide (TiO) particles on tumor necrosis factor (TNFa) production, relative survival, and phagocytosis in cultured murine macrophages AN - 41994128; 3086826 AU - Goering, P L AU - Kish, CL AU - Kuester, R K AU - Hitchins, V M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41994128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+titanium+oxide+%28TiO%29+particles+on+tumor+necrosis+factor+%28TNFa%29+production%2C+relative+survival%2C+and+phagocytosis+in+cultured+murine+macrophages&rft.au=Goering%2C+P+L%3BKish%2C+CL%3BKuester%2C+R+K%3BHitchins%2C+V+M&rft.aulast=Goering&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Poster Paper No. 900 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surrogate markers in early clinical trials AN - 41965804; 3064417 AU - Feigal, D W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MULTIDISCIPLINARY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41965804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Surrogate+markers+in+early+clinical+trials&rft.au=Feigal%2C+D+W&rft.aulast=Feigal&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM PressP.O. Box 605 Herndon, VA 22070; ph: (703)787-3305, Program and Abstracts N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research protocol for patient outcomes evaluation of geriatric physician faculty fellowships AN - 41961906; 3076553 AU - Cogliano, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41961906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Research+protocol+for+patient+outcomes+evaluation+of+geriatric+physician+faculty+fellowships&rft.au=Cogliano%2C+J+F&rft.aulast=Cogliano&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Gerontologist, 1275 K St., NW, Suite 350, Washington, DC 20005-4006, Selected abstracts. Price $10.. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental defects induced by organophosphorus compounds in anuran embryos AN - 41953521; 3075117 AU - Snawder, JE AU - Fulton, M H AU - Chambers, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 5500:GEOSCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41953521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Developmental+defects+induced+by+organophosphorus+compounds+in+anuran+embryos&rft.au=Snawder%2C+JE%3BFulton%2C+M+H%3BChambers%2C+JE&rft.aulast=Snawder&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Environmenral Toxicology and Chemistry, 1010 North 12th Ave., Pensacola, FL 32501 Telephone:(904)469-1500, Abstracts. Price $30.. Paper No. 193 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetics and metabolism of waterborne chlorpyrifos in channel catfish AN - 41950114; 3075679 AU - Plakas, S M AU - Barron, M G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 5500:GEOSCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41950114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pharmacokinetics+and+metabolism+of+waterborne+chlorpyrifos+in+channel+catfish&rft.au=Plakas%2C+S+M%3BBarron%2C+M+G&rft.aulast=Plakas&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Environmenral Toxicology and Chemistry, 1010 North 12th Ave., Pensacola, FL 32501 Telephone:(904)469-1500, Abstracts. Price $30.. Poster Paper No. P269 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender differences in bone mineralization among rats fed flaxseed AN - 41923039; 3047141 AU - Kaup, S M AU - Hight, S C AU - Ahn, S M AU - Rader, JI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41923039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Gender+differences+in+bone+mineralization+among+rats+fed+flaxseed&rft.au=Kaup%2C+S+M%3BHight%2C+S+C%3BAhn%2C+S+M%3BRader%2C+JI&rft.aulast=Kaup&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Poster Paper No. 635 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rayleigh task performance in tomographic reconstructions: Comparison of human and machine performance AN - 41913995; 2977811 AU - Wagner, R F AU - Myers, K J AU - Hanson, K M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 8000:PHYSICS AND ASTRONOMY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rayleigh+task+performance+in+tomographic+reconstructions%3A+Comparison+of+human+and+machine+performance&rft.au=Wagner%2C+R+F%3BMyers%2C+K+J%3BHanson%2C+K+M&rft.aulast=Wagner&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: SPIE, PO Box 10, Bellingham, WA 98227-0010, USA; Phone: 206/676/3290; Fax: 206/647-1445; Internet: spieom.spie.org; Telex: 46-7053; OPTO-LINK: 206/733-2998, Proceedings Paper No. 1898-64 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory response gene expression in rejecting MHC class II disparate grafts AN - 41899575; 3047970 AU - Henricson, B AU - Rosenberg, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inflammatory+response+gene+expression+in+rejecting+MHC+class+II+disparate+grafts&rft.au=Henricson%2C+B%3BRosenberg%2C+A&rft.aulast=Henricson&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 299 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recovery from midazolam sedation AN - 41891368; 2930402 AU - Wright, C AU - Spyker, D AU - Harter, J G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41891368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Recovery+from+midazolam+sedation&rft.au=Wright%2C+C%3BSpyker%2C+D%3BHarter%2C+J+G&rft.aulast=Wright&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT, 1718 Gallagher Rd., Norristown, PA 19401-2800, USA; Telephone: (215) 825-3838; Fax: (215) 834-8652, Abstracts Poster Paper No. PIII-46 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of OTC drug usage studies AN - 41872887; 2930443 AU - Katz, L M AU - Stein, R A AU - Harter, J G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analysis+of+OTC+drug+usage+studies&rft.au=Katz%2C+L+M%3BStein%2C+R+A%3BHarter%2C+J+G&rft.aulast=Katz&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT, 1718 Gallagher Rd., Norristown, PA 19401-2800, USA; Telephone: (215) 825-3838; Fax: (215) 834-8652, Abstracts Poster Paper No. PIII-60 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling pain and its response to analgesics AN - 41870222; 2929742 AU - Harter, J AU - Katzper, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41870222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modeling+pain+and+its+response+to+analgesics&rft.au=Harter%2C+J%3BKatzper%2C+M&rft.aulast=Harter&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT, 1718 Gallagher Rd., Norristown, PA 19401-2800, USA; Telephone: (215) 825-3838; Fax: (215) 834-8652, Abstracts Poster Paper No. PII-4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Persistent HIV-1 (MN) infection of mammary epithelial cells in vitro AN - 41857093; 2935263 AU - Poffenberger, K L AU - Riordan, G AU - Lee, S AU - Epstein, J AU - Hewlett, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Persistent+HIV-1+%28MN%29+infection+of+mammary+epithelial+cells+in+vitro&rft.au=Poffenberger%2C+K+L%3BRiordan%2C+G%3BLee%2C+S%3BEpstein%2C+J%3BHewlett%2C+I&rft.aulast=Poffenberger&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Poster Paper No. Q242 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of inter-animal variability on the estimation of population pharmacokinetic (PK) parameters in preclinical studies AN - 41855708; 2930375 AU - Ette, E AU - Kelman, A AU - Howie, C AU - Whiting, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Influence+of+inter-animal+variability+on+the+estimation+of+population+pharmacokinetic+%28PK%29+parameters+in+preclinical+studies&rft.au=Ette%2C+E%3BKelman%2C+A%3BHowie%2C+C%3BWhiting%2C+B&rft.aulast=Ette&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT, 1718 Gallagher Rd., Norristown, PA 19401-2800, USA; Telephone: (215) 825-3838; Fax: (215) 834-8652, Abstracts Poster Paper No. PIII-38 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutagenicity of coal dust and smokeless tobacco extracts in Salmonella typhimurium strains with differing levels of O-acetyltransferase activities AN - 41854884; 2934149 AU - Stamm, S C AU - Zhong, B-Z AU - Whong, W-Z AU - Ong, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mutagenicity+of+coal+dust+and+smokeless+tobacco+extracts+in+Salmonella+typhimurium+strains+with+differing+levels+of+O-acetyltransferase+activities&rft.au=Stamm%2C+S+C%3BZhong%2C+B-Z%3BWhong%2C+W-Z%3BOng%2C+T&rft.aulast=Stamm&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 9th Floor, 605 Third Avenue, New York, NY 10158, USA; Telephone: (212) 850-6543, Abstracts, Environmental and Molecular Mutagenesis, Volume 21, Supplement 22, 1993, ISSN: 0893-6692 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Familial myositis cases emphasize the roles of genetic and environmental factors in the pathogenesis of idiopathic inflammatory myopathy (IIM) AN - 41853934; 2836359 AU - Gurley, R C AU - Targoff, IN AU - Garcia-de la Torre, AU - Hennekam, RCM AU - Kalovidouris, A E AU - Baumbach, L L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Familial+myositis+cases+emphasize+the+roles+of+genetic+and+environmental+factors+in+the+pathogenesis+of+idiopathic+inflammatory+myopathy+%28IIM%29&rft.au=Gurley%2C+R+C%3BTargoff%2C+IN%3BGarcia-de+la+Torre%2C%3BHennekam%2C+RCM%3BKalovidouris%2C+A+E%3BBaumbach%2C+L+L&rft.aulast=Gurley&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ACR, Paper No. A123 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of cell transformation and oncogene activation by silica dust in BALB/C-3T3 cells AN - 41851343; 2933572 AU - Gao, H-G AU - Whong, W-Z AU - Cutler, D AU - Wallace, W E AU - Ong, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+cell+transformation+and+oncogene+activation+by+silica+dust+in+BALB%2FC-3T3+cells&rft.au=Gao%2C+H-G%3BWhong%2C+W-Z%3BCutler%2C+D%3BWallace%2C+W+E%3BOng%2C+T&rft.aulast=Gao&rft.aufirst=H-G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 9th Floor, 605 Third Avenue, New York, NY 10158, USA; Telephone: (212) 850-6543, Abstracts, Environmental and Molecular Mutagenesis, Volume 21, Supplement 22, 1993, ISSN: 0893-6692 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of the pharmacokinetic/pharmacodynamic (PK/PD) performance of controlled release dosage forms (CRDF) involving partial AUCs AN - 41849285; 2929922 AU - Baweja, R AU - Longley, R AU - Johnson, S AU - Malinowski, HJ AU - Leonard, E M AU - Temple, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Assessment+of+the+pharmacokinetic%2Fpharmacodynamic+%28PK%2FPD%29+performance+of+controlled+release+dosage+forms+%28CRDF%29+involving+partial+AUCs&rft.au=Baweja%2C+R%3BLongley%2C+R%3BJohnson%2C+S%3BMalinowski%2C+HJ%3BLeonard%2C+E+M%3BTemple%2C+R+J&rft.aulast=Baweja&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT, 1718 Gallagher Rd., Norristown, PA 19401-2800, USA; Telephone: (215) 825-3838; Fax: (215) 834-8652, Abstracts Poster Paper No. PII-63 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Demographic analysis of pharmacokinetics (PK) studies submitted for a new drug AN - 41847609; 2930337 AU - Hale, V G AU - Ludden, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Demographic+analysis+of+pharmacokinetics+%28PK%29+studies+submitted+for+a+new+drug&rft.au=Hale%2C+V+G%3BLudden%2C+T&rft.aulast=Hale&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT, 1718 Gallagher Rd., Norristown, PA 19401-2800, USA; Telephone: (215) 825-3838; Fax: (215) 834-8652, Abstracts Poster Paper No. PIII-26 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - sIg mediated desensitization of PLC dependent pathways occurs at a point distal to tyrosine kinase (TK) activation AN - 41835157; 2903067 AU - Brunswick, M AU - June, C AU - Burkhardt, A AU - Bolen, J AU - Mond, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=sIg+mediated+desensitization+of+PLC+dependent+pathways+occurs+at+a+point+distal+to+tyrosine+kinase+%28TK%29+activation&rft.au=Brunswick%2C+M%3BJune%2C+C%3BBurkhardt%2C+A%3BBolen%2C+J%3BMond%2C+J&rft.aulast=Brunswick&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17B 1993, ISSN: 0730-2312 Poster Paper No. FZ440 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of DNA adducts, micronuclei and sister chromatid exchanges by three industrial PAHs in the rat lung cell system AN - 41831518; 2935210 AU - Whong, W-Z AU - Stewart, J AU - Cutler, D AU - Ong, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41831518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+DNA+adducts%2C+micronuclei+and+sister+chromatid+exchanges+by+three+industrial+PAHs+in+the+rat+lung+cell+system&rft.au=Whong%2C+W-Z%3BStewart%2C+J%3BCutler%2C+D%3BOng%2C+T&rft.aulast=Whong&rft.aufirst=W-Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 9th Floor, 605 Third Avenue, New York, NY 10158, USA; Telephone: (212) 850-6543, Abstracts, Environmental and Molecular Mutagenesis, Volume 21, Supplement 22, 1993, ISSN: 0893-6692 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Associations among Gm phenotypes, HLA alleles, and myositis-specific autoantibodies (MSA) in idiopathic inflammatory myopathy (IIM) AN - 41822979; 2831572 AU - Enz, LA AU - Love, LA AU - Targoff, IN AU - Pandey, J P AU - Miller, F W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41822979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Associations+among+Gm+phenotypes%2C+HLA+alleles%2C+and+myositis-specific+autoantibodies+%28MSA%29+in+idiopathic+inflammatory+myopathy+%28IIM%29&rft.au=Enz%2C+LA%3BLove%2C+LA%3BTargoff%2C+IN%3BPandey%2C+J+P%3BMiller%2C+F+W&rft.aulast=Enz&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ACR, Paper No. 107 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of restriction endonucleases on HIV infection AN - 41820998; 2928672 AU - Sechler, JMG AU - Clouse, KA AU - Strebel, K AU - Weih, KA AU - Rosenberg, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+restriction+endonucleases+on+HIV+infection&rft.au=Sechler%2C+JMG%3BClouse%2C+KA%3BStrebel%2C+K%3BWeih%2C+KA%3BRosenberg%2C+A+S&rft.aulast=Sechler&rft.aufirst=JMG&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. N 356 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue-specific regulation of IL-6 production by IL-4: Differential effects of IL-4 on monocytes and fibroblasts AN - 41813414; 2911565 AU - Donnelly, R P AU - Crofford, L J AU - Remmers, E AU - Obiri, N AU - Fenton, MJ AU - Wilder, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41813414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tissue-specific+regulation+of+IL-6+production+by+IL-4%3A+Differential+effects+of+IL-4+on+monocytes+and+fibroblasts&rft.au=Donnelly%2C+R+P%3BCrofford%2C+L+J%3BRemmers%2C+E%3BObiri%2C+N%3BFenton%2C+MJ%3BWilder%2C+R+L&rft.aulast=Donnelly&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17B 1993, ISSN: 0732-2312 Poster Paper no. EZ403 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein purification: Scientific and regulatory consideration on glycosylation, deamidation and oxidation of pharmaceutical proteins AN - 41813041; 2916240 AU - Liu, D T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41813041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Protein+purification%3A+Scientific+and+regulatory+consideration+on+glycosylation%2C+deamidation+and+oxidation+of+pharmaceutical+proteins&rft.au=Liu%2C+D+T&rft.aulast=Liu&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Paper No. X1-023 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon- gamma rapidly induces in human monocytes a novel DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high affinity Fc gamma receptor AN - 41810266; 2882799 AU - Finbloom, D S AU - Wilson, K C AU - Feldman, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41810266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interferon-+gamma+rapidly+induces+in+human+monocytes+a+novel+DNA-binding+factor+that+recognizes+the+gamma+response+region+within+the+promoter+of+the+gene+for+the+high+affinity+Fc+gamma+receptor&rft.au=Finbloom%2C+D+S%3BWilson%2C+K+C%3BFeldman%2C+G&rft.aulast=Finbloom&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Poster Paper No. B135 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon- gamma destabilizes granulocyte-macrophage colony-stimulating factor mRNA induced by interleukin-1 in murine endothelial cells AN - 41785928; 2819482 AU - Akahane, K AU - Pluznik, D H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41785928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interferon-+gamma+destabilizes+granulocyte-macrophage+colony-stimulating+factor+mRNA+induced+by+interleukin-1+in+murine+endothelial+cells&rft.au=Akahane%2C+K%3BPluznik%2C+D+H&rft.aulast=Akahane&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Springer-Verlag New York Inc., Journal Fulfillment Services, 44 Hartz Way, Seacaucus, NJ 07096, USA; Telephone: 1-800-SPRINGER; Telex: 12 59 94, Abstracts, Experimental Hematology, Volume 20, Number 6, July 1992, ISSN: 0301-472X Poster Paper No. 197 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two distinct pathways, dependent and independent of Ca++, are involved in granulocyte macrophage-colony stimulating factor mRNA stabilization in murine T cells AN - 41776429; 2819201 AU - Iwai, Y AU - Cohen, R B AU - Pluznik, D H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41776429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Selenium%2C+an+antioxidant%2C+attenuates+methamphetamine-induced+dopaminergic+toxicity+and+peroxynitrite+generation.&rft.au=Imam%2C+S+Z%3BAli%2C+S+F&rft.aulast=Imam&rft.aufirst=S&rft.date=2000-02-07&rft.volume=855&rft.issue=1&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Springer-Verlag New York Inc., Journal Fulfillment Services, 44 Hartz Way, Seacaucus, NJ 07096, USA; 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Telephone: (415) 508-0118; Fax: (415) 595-4864 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Canda's for CBER AN - 41758641; 2829589 AU - Bell, R A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41758641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Canda%27s+for+CBER&rft.au=Trapnell%2C+C+B&rft.aulast=Trapnell&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IBEX, 1070 Sixth Ave., Suite 309, Belmont, CA 94002, USA; Telephone: (415) 508-0118; Fax: (415) 595-4864 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular mimicry between HIV 1 gp41 and HLA class II: Correlation between the generation of crossreactive antibodies, T cell function, and disease progression in infected individuals AN - 41723600; 2654543 AU - Golding, H AU - Clerici, M AU - Mann, D AU - Shearer, G M AU - Blackburn, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41723600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+mimicry+between+HIV+1+gp41+and+HLA+class+II%3A+Correlation+between+the+generation+of+crossreactive+antibodies%2C+T+cell+function%2C+and+disease+progression+in+infected+individuals&rft.au=Golding%2C+H%3BClerici%2C+M%3BMann%2C+D%3BShearer%2C+G+M%3BBlackburn%2C+R&rft.aulast=Golding&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. M.A.16 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemically induced mutants of the CEM cell line demonstrate partial blockade of their PKC-dependent pathways and reduced susceptibility to HIV 1 infection AN - 41715060; 2656052 AU - Hillman, K AU - Gruber, M F AU - Kaufman, J AU - Blackburn, R AU - Manischewitz, J AU - Norcross, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41715060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pivotal+efficacy+requirement+in+designing+acceptable+phase+III+trail+to+support+a+PLA&rft.au=Woodcock%2C+J&rft.aulast=Woodcock&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.A.1140 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of HIV-1 from chronically infected promonocytic cells by chemical carcinogens AN - 41712330; 2656567 AU - Hewlett, I AU - Joshi, B AU - Riordan, G AU - Lee, G AU - Pollock, L AU - Epstein, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41712330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+HIV-1+from+chronically+infected+promonocytic+cells+by+chemical+carcinogens&rft.au=Hewlett%2C+I%3BJoshi%2C+B%3BRiordan%2C+G%3BLee%2C+G%3BPollock%2C+L%3BEpstein%2C+J&rft.aulast=Hewlett&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.A.1190 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokines and cellular therapy AN - 41705920; 2690911 AU - Gunter, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41705920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokines+and+cellular+therapy&rft.au=Gunter%2C+K&rft.aulast=Gunter&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: BioEast '92, 1651 Third Avenue, Suite 301, New York, NY 10128, USA. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro and in vivo activity of HIV protease inhibitors in an animal retroviral model AN - 41665785; 2665593 AU - Ussery, MA AU - Black, P L AU - Downs, M B AU - Lewis, M G AU - Lambert, D M AU - Dreyer, G B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41665785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+and+in+vivo+activity+of+HIV+protease+inhibitors+in+an+animal+retroviral+model&rft.au=Ussery%2C+MA%3BBlack%2C+P+L%3BDowns%2C+M+B%3BLewis%2C+M+G%3BLambert%2C+D+M%3BDreyer%2C+G+B&rft.aulast=Ussery&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. W.A.68 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bacteriophage typing of Listeria monocytogenes isolated from foods AN - 41647469; 2534630 AU - Estela, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41647469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bacteriophage+typing+of+Listeria+monocytogenes+isolated+from+foods&rft.au=Estela%2C+L&rft.aulast=Estela&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Poster Paper No. P33 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of extracellular calcium on inhibition of dye coupling among cardiac myocytes by halogenated hydrocarbons AN - 41647143; 2525945 AU - Breitenstein, MJ AU - Toraason, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41647143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+extracellular+calcium+on+inhibition+of+dye+coupling+among+cardiac+myocytes+by+halogenated+hydrocarbons&rft.au=Breitenstein%2C+MJ%3BToraason%2C+M&rft.aulast=Breitenstein&rft.aufirst=MJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence that lipopolysaccharide from Brucella abortus stimulates murine B cells directly AN - 41644452; 2511552 AU - Goldstein, J S AU - Frasch, C AU - Hernandez, D AU - Beining, PR AU - Betts, M AU - Hoffman, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41644452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+that+lipopolysaccharide+from+Brucella+abortus+stimulates+murine+B+cells+directly&rft.au=Goldstein%2C+J+S%3BFrasch%2C+C%3BHernandez%2C+D%3BBeining%2C+PR%3BBetts%2C+M%3BHoffman%2C+T&rft.aulast=Goldstein&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation of Bordetella pertussis antigen-specific memory B lymphocytes in the respiratory tract AN - 41635472; 2536537 AU - Amsbaugh, D F AU - Manclark, C R AU - Shahin, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41635472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+reduced+dietary+protein+levels+on+the+early+resistance+of+mice+to+virulent+and+avirulent+Listeria+species&rft.au=Smith%2C+B+G%3BWess%2C+JA%3BRhea%2C+U+S%3BShah%2C+D+B%3BPetro%2C+T+M&rft.aulast=Smith&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Poster Paper No. B150 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medical studies of the poisonous land and sea snakes in and around Saudi Arabia AN - 41634525; 2494045 AU - Vick, JA AU - Herman, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41634525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Shelf+life+of+modified+atmosphere-packaged+fresh+salmon+fillets+stored+under+refrigeration+and+temperature+abuse+conditions&rft.au=Reddy%2C+N+R%3BVillanueva%2C+M%3BKautter%2C+DA&rft.aulast=Reddy&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism of acrylonitrile by Klebsiella pneumoniae AN - 41630276; 2538520 AU - Nawaz, M AU - Franklin, W AU - Campbell, W AU - Heinz, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41630276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metabolism+of+acrylonitrile+by+Klebsiella+pneumoniae&rft.au=Nawaz%2C+M%3BFranklin%2C+W%3BCampbell%2C+W%3BHeinz%2C+T&rft.aulast=Nawaz&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Paper No. K95 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flow microfluorimetric analysis of bacterial phagocytosis by J774A.1 macrophages AN - 41630053; 2520739 AU - Raybourne, R B AU - Bunning, V K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41630053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Flow+microfluorimetric+analysis+of+bacterial+phagocytosis+by+J774A.1+macrophages&rft.au=Raybourne%2C+R+B%3BBunning%2C+V+K&rft.aulast=Raybourne&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strain-dependent restricted V sub(H) usage by anti-bacterial levan monoclonal antibodies AN - 41627428; 2530791 AU - Boswell, C AU - Goodnight, J AU - Irwin, D AU - Stein, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41627428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Strain-dependent+restricted+V+sub%28H%29+usage+by+anti-bacterial+levan+monoclonal+antibodies&rft.au=Boswell%2C+C%3BGoodnight%2C+J%3BIrwin%2C+D%3BStein%2C+K&rft.aulast=Boswell&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Copper status in weanling rats fed low levels of inorganic tin AN - 41624190; 2514405 AU - Rader, JI AU - Hight, S C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41624190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Copper+status+in+weanling+rats+fed+low+levels+of+inorganic+tin&rft.au=Rader%2C+JI%3BHight%2C+S+C&rft.aulast=Rader&rft.aufirst=JI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monoclonal antibody analysis of benzopyrene-induced fetal T cell antigens AN - 41623783; 2528988 AU - Herd, Z AU - Henningsen, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41623783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Monoclonal+antibody+analysis+of+benzopyrene-induced+fetal+T+cell+antigens&rft.au=Herd%2C+Z%3BHenningsen%2C+G&rft.aulast=Herd&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurochemical effects of prenatal ethanol administration in rat AN - 41622169; 2508220 AU - Briggs, F AU - Headings, V AU - Pradhan, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41622169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurochemical+effects+of+prenatal+ethanol+administration+in+rat&rft.au=Briggs%2C+F%3BHeadings%2C+V%3BPradhan%2C+S&rft.aulast=Briggs&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical considerations for the development of intravitreal drug products AN - 41622004; 3460292 AU - Weir, A AU - Chambers, W AU - Chen, C AU - Chen, Z AU - Mukherjee, A AU - Wilson, S AU - Yang, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41622004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preclinical+considerations+for+the+development+of+intravitreal+drug+products&rft.au=Weir%2C+A%3BChambers%2C+W%3BChen%2C+C%3BChen%2C+Z%3BMukherjee%2C+A%3BWilson%2C+S%3BYang%2C+J&rft.aulast=Weir&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1524 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Major neutralizing epitope of HIV-1 depends on protein conformation and maps to the carboxyl third of GP 120 AN - 41620233; 2503141 AU - Berkower, I AU - Murphy, D AU - Smith, C AU - Smith, GE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41620233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Major+neutralizing+epitope+of+HIV-1+depends+on+protein+conformation+and+maps+to+the+carboxyl+third+of+GP+120&rft.au=Berkower%2C+I%3BMurphy%2C+D%3BSmith%2C+C%3BSmith%2C+GE&rft.aulast=Berkower&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution and expression of pneumolysin in Streptococcus pneumoniae AN - 41618836; 2527343 AU - Li, J AU - Tai, S AU - Nguyen, N AU - Lee, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41618836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+and+expression+of+pneumolysin+in+Streptococcus+pneumoniae&rft.au=Li%2C+J%3BTai%2C+S%3BNguyen%2C+N%3BLee%2C+C&rft.aulast=Li&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimating historical respirable crystalline silica exposures for Chinese pottery workers and iron/copper, tin, and tungsten miners AN - 41617401; 3466045 AU - Zhuang, Z AU - Hearl, F AU - Chen, B AU - McCawley, M AU - Gao, P AU - Soderholm, S AU - Chen, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41617401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Estimating+historical+respirable+crystalline+silica+exposures+for+Chinese+pottery+workers+and+iron%2Fcopper%2C+tin%2C+and+tungsten+miners&rft.au=Zhuang%2C+Z%3BHearl%2C+F%3BChen%2C+B%3BMcCawley%2C+M%3BGao%2C+P%3BSoderholm%2C+S%3BChen%2C+W&rft.aulast=Zhuang&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 2700 Prosperity Ave., Suite 250, Fairfax, VA 22031-4307, USA; phone: 703-849-8888; email: aiche@laserreg.com; URL: www.aiha.org/aiche99/info.html, Abstracs available. 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Poster Paper No. 445 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How the draft guidance evolved into the new guidance document AN - 41616420; 3462668 AU - McCormack, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41616420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=How+the+draft+guidance+evolved+into+the+new+guidance+document&rft.au=McCormack%2C+J+F&rft.aulast=McCormack&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Drug Information Association, 501 Office Center Drive, Suite 450, Fort Washington, PA 19034-3211, USA; phone: 215-628-2288; fax: 215-641-1229; email: brax@diahome.org; URL: www.diahome.org, Abstracts available. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antibody responses of MHC cogenic mice to the human CD4 site binding gp120 of HIV-1 AN - 41615795; 2503154 AU - Reeves, J P AU - Lo, C-Y AU - Epstein, S L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41615795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Antibody+responses+of+MHC+cogenic+mice+to+the+human+CD4+site+binding+gp120+of+HIV-1&rft.au=Reeves%2C+J+P%3BLo%2C+C-Y%3BEpstein%2C+S+L&rft.aulast=Reeves&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory update on Thailand and regional harmonization AN - 41614256; 3462508 AU - Na Songkhia, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41614256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulatory+update+on+Thailand+and+regional+harmonization&rft.au=Na+Songkhia%2C+M&rft.aulast=Na+Songkhia&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Drug Information Association, 501 Office Center Drive, Suite 450, Fort Washington, PA 19034-3211, USA; phone: 215-628-2288; fax: 215-641-1229; email: brax@diahome.org; URL: www.diahome.org, Abstracts available. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Either umuDC or sam is sufficient for UV mutagenesis in Salmonella typhimurium AN - 41612352; 2533355 AU - Koch, W H AU - Cebula, T A AU - Franklin, S B AU - Foster, P L AU - Eisenstadt, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41612352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Either+umuDC+or+sam+is+sufficient+for+UV+mutagenesis+in+Salmonella+typhimurium&rft.au=Koch%2C+W+H%3BCebula%2C+T+A%3BFranklin%2C+S+B%3BFoster%2C+P+L%3BEisenstadt%2C+E&rft.aulast=Koch&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Poster Paper No. H14 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Video exposure monitoring of jet fuel tank entry personnel at U.S. Air Force and commercial maintenance facilities AN - 41612282; 3466022 AU - Jensen, P AU - Dower, J AU - Kinnes, G AU - Mead, K AU - Watkins, D AU - Carlton, G AU - Smith, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41612282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Video+exposure+monitoring+of+jet+fuel+tank+entry+personnel+at+U.S.+Air+Force+and+commercial+maintenance+facilities&rft.au=Jensen%2C+P%3BDower%2C+J%3BKinnes%2C+G%3BMead%2C+K%3BWatkins%2C+D%3BCarlton%2C+G%3BSmith%2C+L&rft.aulast=Jensen&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 2700 Prosperity Ave., Suite 250, Fairfax, VA 22031-4307, USA; phone: 703-849-8888; email: aiche@laserreg.com; URL: www.aiha.org/aiche99/info.html, Abstracs available. 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Poster Paper No. 422 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morphological changes in rats fed beta -carotene and varied protein sources AN - 41611574; 2500390 AU - Jenkins, MY AU - Sheikh, N M AU - Mitchell, G V AU - Grundel, G AU - Blakely Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41611574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Morphological+changes+in+rats+fed+beta+-carotene+and+varied+protein+sources&rft.au=Jenkins%2C+MY%3BSheikh%2C+N+M%3BMitchell%2C+G+V%3BGrundel%2C+G%3BBlakely&rft.aulast=Jenkins&rft.aufirst=MY&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Review of the physiological variables and constants used in the Coburn-Forster-Kane equation to predict carboxyhemoglobin levels AN - 41611063; 3465961 AU - Burr, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41611063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Review+of+the+physiological+variables+and+constants+used+in+the+Coburn-Forster-Kane+equation+to+predict+carboxyhemoglobin+levels&rft.au=Burr%2C+G&rft.aulast=Burr&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 2700 Prosperity Ave., Suite 250, Fairfax, VA 22031-4307, USA; phone: 703-849-8888; email: aiche@laserreg.com; URL: www.aiha.org/aiche99/info.html, Abstracs available. 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Poster Paper No. 366 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potential problematical glycoalkaloids in pork chops AN - 41608440; 3459045 AU - Betz, J M AU - Garland, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41608440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Potential+problematical+glycoalkaloids+in+pork+chops&rft.au=Betz%2C+J+M%3BGarland%2C+T&rft.aulast=Betz&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 277 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the terminal lipid of group C meningococcal polysaccharide in immunoassays AN - 41606723; 2537285 AU - Arakere, G AU - Frasch, CE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41606723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Breast-feeding+exposure+of+infants+to+selected+pesticides%3A+a+public+health+viewpoint.&rft.au=Pohl%2C+H+R%3BTylenda%2C+C+A&rft.aulast=Pohl&rft.aufirst=H&rft.date=2000-02-01&rft.volume=16&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Paper No. J12 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Binding specificity of Mycoplasma hominis 1620 AN - 41606306; 2537162 AU - Olson, L D AU - Gilbert, A A AU - Barile, M F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41606306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Binding+specificity+of+Mycoplasma+hominis+1620&rft.au=Olson%2C+L+D%3BGilbert%2C+A+A%3BBarile%2C+M+F&rft.aulast=Olson&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Paper No. G34 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bacterial plasmids as indicators of potential fecal contamination to shellfish-growing waters AN - 41606063; 2537037 AU - Motes, ML Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41606063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bacterial+plasmids+as+indicators+of+potential+fecal+contamination+to+shellfish-growing+waters&rft.au=Motes%2C+ML+Jr&rft.aulast=Motes&rft.aufirst=ML&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Paper No. Q155 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemagglutination properties of capsular polysaccharide from Salmonella enteritidis AN - 41605665; 2534147 AU - Gayle, AB AU - Hanes, DE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41605665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hemagglutination+properties+of+capsular+polysaccharide+from+Salmonella+enteritidis&rft.au=Gayle%2C+AB%3BHanes%2C+DE&rft.aulast=Gayle&rft.aufirst=AB&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Poster Paper No. P16 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of exposure to asphalt fume condensate (AFC) on acute inflammatory responses AN - 41605132; 3459328 AU - Ma, JYC AU - Barger, M W AU - Kreich, A J AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41605132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+exposure+to+asphalt+fume+condensate+%28AFC%29+on+acute+inflammatory+responses&rft.au=Ma%2C+JYC%3BBarger%2C+M+W%3BKreich%2C+A+J%3BCastranova%2C+V&rft.aulast=Ma&rft.aufirst=JYC&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 560 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse responses to semisynthetic metal working fluids in B6C3F1 mice AN - 41604710; 3459121 AU - Al-Humadi, N H AU - Kommineni, C AU - Shvedova, A A AU - Battelli, L AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41604710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adverse+responses+to+semisynthetic+metal+working+fluids+in+B6C3F1+mice&rft.au=Al-Humadi%2C+N+H%3BKommineni%2C+C%3BShvedova%2C+A+A%3BBattelli%2C+L%3BCastranova%2C+V&rft.aulast=Al-Humadi&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 353 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antagonism toward Listeria monocytogenes by competitors in enrichment culture AN - 41604672; 2537238 AU - Dallas, H L AU - Hitchins, AD Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41604672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Antagonism+toward+Listeria+monocytogenes+by+competitors+in+enrichment+culture&rft.au=Dallas%2C+H+L%3BHitchins%2C+AD&rft.aulast=Dallas&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Paper No. P41 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human pathogens in a shellfish growing area contributed by non-point sources AN - 41604358; 2537033 AU - Kaysner, C AU - Abeyta, C Jr AU - Stott, R AU - Wetherington, J AU - Colburn, K AU - Wekell, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41604358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+pathogens+in+a+shellfish+growing+area+contributed+by+non-point+sources&rft.au=Kaysner%2C+C%3BAbeyta%2C+C+Jr%3BStott%2C+R%3BWetherington%2C+J%3BColburn%2C+K%3BWekell%2C+M&rft.aulast=Kaysner&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Paper No. Q154 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of oxytetracycline on development and persistence of antibiotic-resistant bacteria in catfish ponds AN - 41602207; 2542658 AU - Depaola, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41602207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+oxytetracycline+on+development+and+persistence+of+antibiotic-resistant+bacteria+in+catfish+ponds&rft.au=Depaola%2C+A&rft.aulast=Depaola&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Poster Paper No. Q251 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotoxicity and immunological changes in isocyanate exposed brown Norway rats AN - 41601915; 3459377 AU - Siegel, P D AU - Zhong, B-Z AU - Lawrence, TE AU - Lewis, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41601915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genotoxicity+and+immunological+changes+in+isocyanate+exposed+brown+Norway+rats&rft.au=Siegel%2C+P+D%3BZhong%2C+B-Z%3BLawrence%2C+TE%3BLewis%2C+D+M&rft.aulast=Siegel&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 609 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro percutaneous absorption and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin AN - 41601201; 3459114 AU - Yourick, J J AU - Bronaugh, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41601201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+percutaneous+absorption+and+metabolism+of+2-nitro-p-phenylenediamine+in+human+and+fuzzy+rat+skin&rft.au=Yourick%2C+J+J%3BBronaugh%2C+R+L&rft.aulast=Yourick&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 346 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consumption of dietary fibers with different potentials to alter colonic carcinogenesis differentially affects colonic luminal immunoreactive EGF levels in rats AN - 41600038; 2514547 AU - Calvert, R J AU - Satchithanandam, S AU - Schaudies, R P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41600038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Consumption+of+dietary+fibers+with+different+potentials+to+alter+colonic+carcinogenesis+differentially+affects+colonic+luminal+immunoreactive+EGF+levels+in+rats&rft.au=Calvert%2C+R+J%3BSatchithanandam%2C+S%3BSchaudies%2C+R+P&rft.aulast=Calvert&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - cAMP inhibits T cell receptor-induced hydrolysis of inositol phospholipids at a level proximal to phospholipase C activation AN - 41599365; 2525647 AU - Alava, MA AU - DeBell, KE AU - Taplits AU - Hoffman, T AU - Bonvini, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41599365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=cAMP+inhibits+T+cell+receptor-induced+hydrolysis+of+inositol+phospholipids+at+a+level+proximal+to+phospholipase+C+activation&rft.au=Alava%2C+MA%3BDeBell%2C+KE%3BTaplits%3BHoffman%2C+T%3BBonvini%2C+E&rft.aulast=Alava&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral toxicity of ethanol in rats AN - 41598706; 3460460 AU - Popke, E J AU - Allen AU - Fogle, C M AU - Paule, M G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41598706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Behavioral+toxicity+of+ethanol+in+rats&rft.au=Popke%2C+E+J%3BAllen%3BFogle%2C+C+M%3BPaule%2C+M+G&rft.aulast=Popke&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1692 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential effects of trimethyltin on tasks related to time estimation and appetitive motivation in rats AN - 41598140; 3460480 AU - Mayorga, A J AU - Fogle, C M AU - Paule, M G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41598140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+effects+of+trimethyltin+on+tasks+related+to+time+estimation+and+appetitive+motivation+in+rats&rft.au=Mayorga%2C+A+J%3BFogle%2C+C+M%3BPaule%2C+M+G&rft.aulast=Mayorga&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1712 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Animal models design: Asking the right questions AN - 41597799; 3462228 AU - Witten, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41597799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Animal+models+design%3A+Asking+the+right+questions&rft.au=Witten%2C+C&rft.aulast=Witten&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cambridge Healthtech Institute, 1037 Chestnut Street, Newton Upper Falls, MA 02464, USA; phone: 617-630-1300; fax: 617-630-1325; email: chi@healthtech.com; URL: http://www.healthtech.com, Abstracts available. Price $195 + S & H. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purification and characterization of soluble EGF receptors secreted from A431 cells AN - 41597503; 2527587 AU - Liu, S-Y AU - Williams, T AU - Komoriya, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41597503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Purification+and+characterization+of+soluble+EGF+receptors+secreted+from+A431+cells&rft.au=Liu%2C+S-Y%3BWilliams%2C+T%3BKomoriya%2C+A&rft.aulast=Liu&rft.aufirst=S-Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safety assessment of cosmetic ingredients and color additives: Evaluation of a quantitative structure-toxicity relationship approach for predicting toxicity AN - 41596816; 3460296 AU - Milstein AU - Yourick, J J AU - Bronaugh, R L AU - Wamer, W G AU - Lowther, D K AU - Meyers, M B AU - Scher, AL AU - Bell, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41596816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Safety+assessment+of+cosmetic+ingredients+and+color+additives%3A+Evaluation+of+a+quantitative+structure-toxicity+relationship+approach+for+predicting+toxicity&rft.au=Milstein%3BYourick%2C+J+J%3BBronaugh%2C+R+L%3BWamer%2C+W+G%3BLowther%2C+D+K%3BMeyers%2C+M+B%3BScher%2C+AL%3BBell%2C+S+J&rft.aulast=Milstein&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1528 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Four protectors in search of a rating system AN - 41596348; 3448552 AU - Murphy, W J AU - Franks, J R AU - Harris, DA AU - Johnson, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41596348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Four+protectors+in+search+of+a+rating+system&rft.au=Murphy%2C+W+J%3BFranks%2C+J+R%3BHarris%2C+DA%3BJohnson%2C+J+L&rft.aulast=Murphy&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Institute of Physics, 500 Sunnydale Boulevard, Woodbury, NY 11797, USA; URL: asa.aip.org, Abstracts available. Price $100. Poster Paper No. 3aNSb12 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of intermittent exposures of aflatoxin B sub(1) on hepatic and testicular glutathione S-transferase in rats AN - 41595449; 3459678 AU - Sahu, S C AU - Chou, M W AU - Sotomayor, R E AU - Hinton, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41595449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+intermittent+exposures+of+aflatoxin+B+sub%281%29+on+hepatic+and+testicular+glutathione+S-transferase+in+rats&rft.au=Sahu%2C+S+C%3BChou%2C+M+W%3BSotomayor%2C+R+E%3BHinton%2C+D+M&rft.aulast=Sahu&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 910 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PK compartmental (COM) modeling and dose (D) regimen (REG) analysis for concentration controlled trials (CCT) of suramin (SUR) in cancer (CA) using difference equation simulation (DES) AN - 41594253; 2417511 AU - Lieberman, R AU - Katzper, M AU - Peck, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41594253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PK+compartmental+%28COM%29+modeling+and+dose+%28D%29+regimen+%28REG%29+analysis+for+concentration+controlled+trials+%28CCT%29+of+suramin+%28SUR%29+in+cancer+%28CA%29+using+difference+equation+simulation+%28DES%29&rft.au=Lieberman%2C+R%3BKatzper%2C+M%3BPeck%2C+C&rft.aulast=Lieberman&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Ms. Elaine Galasso, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Telephone: (215) 825-3838. Fax: (215) 834-8652., Poster Paper No. PI-2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disease modification: A regulatory perspective AN - 41594029; 3454018 AU - Witter, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41594029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Disease+modification%3A+A+regulatory+perspective&rft.au=Witter%2C+J&rft.aulast=Witter&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Clinical Pharmacology and Therapeutics, 117 West Ridge Pike, Suite 2, Conshohocken, PA 19428-1216, USA; phone: 610-825-3838; fax: 610-834-8652; email: ascpt@aol.com; URL: www.ascpt.org, Abstracts available. Price $20. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute inhalation toxicity of ethylamine, diethylamine and triethylamine - Effects on rodent nasal passages AN - 41590932; 3459319 AU - Lynch, D W AU - Schueler, R L AU - Gorgacz, E J AU - Cheever, K L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41590932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Mercury+induces+regional+and+cell-specific+stress+protein+expression+in+rat+kidney.&rft.au=Goering%2C+P+L%3BFisher%2C+B+R%3BNoren%2C+B+T%3BPapaconstantinou%2C+A%3BRojko%2C+J+L%3BMarler%2C+R+J&rft.aulast=Goering&rft.aufirst=P&rft.date=2000-02-01&rft.volume=53&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 551 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of FGF receptor (FLG) in embryonal rhabdomyosarcoma cells and glioblastomas: Potential involvement in autocrine stimulation AN - 41590485; 2465433 AU - Ruta, M AU - Neiger, N AU - Pollock, L AU - Winkles, J AU - Epstein, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41590485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+FGF+receptor+%28FLG%29+in+embryonal+rhabdomyosarcoma+cells+and+glioblastomas%3A+Potential+involvement+in+autocrine+stimulation&rft.au=Ruta%2C+M%3BNeiger%2C+N%3BPollock%2C+L%3BWinkles%2C+J%3BEpstein%2C+J&rft.aulast=Ruta&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. CF 216 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of immunoglobulin heavy chain variable gene (V sub(H)) in B-chronic lymphocytic leukemia (B-CLL) and B-prolymphocytic leukemia (B-PLL) cell lines: "Restricted" usage of V sub(H)3 family AN - 41589956; 2487437 AU - Bertin, P A AU - Marti, GE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41589956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+immunoglobulin+heavy+chain+variable+gene+%28V+sub%28H%29%29+in+B-chronic+lymphocytic+leukemia+%28B-CLL%29+and+B-prolymphocytic+leukemia+%28B-PLL%29+cell+lines%3A+%22Restricted%22+usage+of+V+sub%28H%293+family&rft.au=Bertin%2C+P+A%3BMarti%2C+GE&rft.aulast=Bertin&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15G, 1991; ISSN: 0730-2312 Poster Paper No. S 209 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of acute ibogaine administration on the performance of complex operant tasks in rats AN - 41587226; 3460117 AU - Xu, Z AU - Mayorga, A J AU - Fogle, C M AU - Scallet, A AU - Chang, L W AU - Slikker, W AU - Paule, M G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41587226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+acute+ibogaine+administration+on+the+performance+of+complex+operant+tasks+in+rats&rft.au=Xu%2C+Z%3BMayorga%2C+A+J%3BFogle%2C+C+M%3BScallet%2C+A%3BChang%2C+L+W%3BSlikker%2C+W%3BPaule%2C+M+G&rft.aulast=Xu&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1349 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4 AN - 41584816; 2443070 AU - Donnelly, R P AU - Fenton, MJ AU - Kaufman, J D AU - Gerrard, T L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41584816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IL-1+expression+in+human+monocytes+is+transcriptionally+and+posttranscriptionally+regulated+by+IL-4&rft.au=Donnelly%2C+R+P%3BFenton%2C+MJ%3BKaufman%2C+J+D%3BGerrard%2C+T+L&rft.aulast=Donnelly&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15E, 1991; ISSN: 0730-2312 Paper No. O 304 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicologic effects of 13-week inhalation exposure to N,N-dimethylformamide in rats and mice AN - 41584633; 2434614 AU - Lynch, D W AU - Placke, ME AU - Persing, R L AU - Ryan, MJ AU - Kurtz, P J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41584633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Toxicologic+effects+of+13-week+inhalation+exposure+to+N%2CN-dimethylformamide+in+rats+and+mice&rft.au=Lynch%2C+D+W%3BPlacke%2C+ME%3BPersing%2C+R+L%3BRyan%2C+MJ%3BKurtz%2C+P+J&rft.aulast=Lynch&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Poster Paper No. 1234 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tetrandrine inhibits synthesis of disaturated phosphatidylcholines in rat alveolar type II cells AN - 41584627; 2523653 AU - Ma, JYC AU - Bowman, L AU - Ma, JKH AU - Miles, PR Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41584627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tetrandrine+inhibits+synthesis+of+disaturated+phosphatidylcholines+in+rat+alveolar+type+II+cells&rft.au=Ma%2C+JYC%3BBowman%2C+L%3BMa%2C+JKH%3BMiles%2C+PR&rft.aulast=Ma&rft.aufirst=JYC&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - bST safety and human consumption AN - 41582797; 2420566 AU - Guyer, C G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MUTIDISCIPLINARY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41582797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=bST+safety+and+human+consumption&rft.au=Guyer%2C+C+G&rft.aulast=Guyer&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AAAS Books, Dept. 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Fax: (301) 843-0159., Abstracts, 91-02, $8.00 members/$10.00 non-members plus $4.00 postage/handling N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - o-Toluidine blood protein adducts: HPLC analysis with fluorescence detection after a single dose in the adult male rat AN - 41582747; 2431836 AU - Cheever, K L AU - DeBord, G D AU - Swearengin, T F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41582747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=o-Toluidine+blood+protein+adducts%3A+HPLC+analysis+with+fluorescence+detection+after+a+single+dose+in+the+adult+male+rat&rft.au=Cheever%2C+K+L%3BDeBord%2C+G+D%3BSwearengin%2C+T+F&rft.aulast=Cheever&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Poster Paper No. 455 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative metabolism of bis(2-methoxy-ethyl)ether in isolated rat hepatocytes and in the intact rat AN - 41581483; 2430795 AU - Richards, DE AU - Begley, K B AU - DeBord, D G AU - Cheever, K L AU - Weigel, W W AU - Savage, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41581483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+metabolism+of+bis%282-methoxy-ethyl%29ether+in+isolated+rat+hepatocytes+and+in+the+intact+rat&rft.au=Richards%2C+DE%3BBegley%2C+K+B%3BDeBord%2C+D+G%3BCheever%2C+K+L%3BWeigel%2C+W+W%3BSavage%2C+R+E&rft.aulast=Richards&rft.aufirst=DE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Poster Paper No. 164 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of PK/PD modeling in drug regulation AN - 41576412; 3462896 AU - Miller, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41576412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+PK%2FPD+modeling+in+drug+regulation&rft.au=Miller%2C+R&rft.aulast=Miller&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Drug Information Association, 501 Office Center Drive, Suite 450, Fort Washington, PA 19034-3211, USA; phone: 215-628-2288; fax: 215-641-1229; email: brax@diahome.org; URL: www.diahome.org, Abstracts available. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transgenic mice and model assay systems for genotoxicity and human diseases AN - 41573195; 2429549 AU - Cordaro, J C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41573195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transgenic+mice+and+model+assay+systems+for+genotoxicity+and+human+diseases&rft.au=Cordaro%2C+J+C&rft.aulast=Cordaro&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Paper No. 9 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential effects of sera on basal and chemical-induced cell proliferation and differentiation in rat embryonic midbrain and limb bud cell micro-mass culture AN - 41567895; 3459082 AU - Park, K S AU - Han, SY AU - Park, K L AU - Hong, J T AU - Kim, H S AU - Park, HJ AU - Kook, S S AU - Lee, R D AU - Choi, Y J AU - Jang, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41567895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+effects+of+sera+on+basal+and+chemical-induced+cell+proliferation+and+differentiation+in+rat+embryonic+midbrain+and+limb+bud+cell+micro-mass+culture&rft.au=Park%2C+K+S%3BHan%2C+SY%3BPark%2C+K+L%3BHong%2C+J+T%3BKim%2C+H+S%3BPark%2C+HJ%3BKook%2C+S+S%3BLee%2C+R+D%3BChoi%2C+Y+J%3BJang%2C+S+J&rft.aulast=Park&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 314 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fate of 2,4-dichlorophenoxyacetic acid following oral administration in channel catfish AN - 41563686; 2465040 AU - Plakas, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 5500:GEOSCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41563686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Fate+of+2%2C4-dichlorophenoxyacetic+acid+following+oral+administration+in+channel+catfish&rft.au=Plakas%2C+S&rft.aulast=Plakas&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASTM, 1916 Race Street, Philadelphia, PA 19103, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancement of conditioned avoidance response (CAR) by B-blockers, N-methyl-D-asparate (NMDA) and acridne 1-OH-THA in mice AN - 41561755; 2432334 AU - Yen-Koo, H AU - Rosloff, B AU - Zhang, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41561755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Enhancement+of+conditioned+avoidance+response+%28CAR%29+by+B-blockers%2C+N-methyl-D-asparate+%28NMDA%29+and+acridne+1-OH-THA+in+mice&rft.au=Yen-Koo%2C+H%3BRosloff%2C+B%3BZhang%2C+J&rft.aulast=Yen-Koo&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Poster Paper No. 591 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defining relevant animal species for toxicity evaluation of biologic therapeutics; Critical groundwork for basing preclinical toxicity program strategies AN - 41561604; 3458958 AU - Black, LE AU - Green, MD Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41561604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Defining+relevant+animal+species+for+toxicity+evaluation+of+biologic+therapeutics%3B+Critical+groundwork+for+basing+preclinical+toxicity+program+strategies&rft.au=Black%2C+LE%3BGreen%2C+MD&rft.aulast=Black&rft.aufirst=LE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Paper No. 190 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endocrine disruptor knowledge base (EKB) AN - 41559894; 3460661 AU - Tong, W AU - Perkins, R AU - Anson, J AU - Branham, W AU - Blair, R AU - Hass, B AU - Fang, H AU - Shi, L AU - Chen, Y AU - Meehan, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41559894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Endocrine+disruptor+knowledge+base+%28EKB%29&rft.au=Tong%2C+W%3BPerkins%2C+R%3BAnson%2C+J%3BBranham%2C+W%3BBlair%2C+R%3BHass%2C+B%3BFang%2C+H%3BShi%2C+L%3BChen%2C+Y%3BMeehan%2C+J&rft.aulast=Tong&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1893 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunogenicity of monoclonal antibodies: Conventional versus engineered AN - 41558147; 3454023 AU - Stein, KE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41558147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunogenicity+of+monoclonal+antibodies%3A+Conventional+versus+engineered&rft.au=Stein%2C+KE&rft.aulast=Stein&rft.aufirst=KE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Clinical Pharmacology and Therapeutics, 117 West Ridge Pike, Suite 2, Conshohocken, PA 19428-1216, USA; phone: 610-825-3838; fax: 610-834-8652; email: ascpt@aol.com; URL: www.ascpt.org, Abstracts available. Price $20. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apparent dose-dependent pharmacodynamics (PD) of nonsteroidal anti-inflammatory drug (NSAID) analgesia AN - 41557186; 2417536 AU - Dockens, R C AU - Harter, J G AU - Peck, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41557186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Apparent+dose-dependent+pharmacodynamics+%28PD%29+of+nonsteroidal+anti-inflammatory+drug+%28NSAID%29+analgesia&rft.au=Dockens%2C+R+C%3BHarter%2C+J+G%3BPeck%2C+C+C&rft.aulast=Dockens&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Ms. Elaine Galasso, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Telephone: (215) 825-3838. Fax: (215) 834-8652., Poster Paper No. PI-5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular taurine content of alveolar pneumocytes AN - 41556215; 2373661 AU - Castranova, V AU - Porter, D W AU - Martin, W G AU - Banks, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41556215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intracellular+taurine+content+of+alveolar+pneumocytes&rft.au=Castranova%2C+V%3BPorter%2C+D+W%3BMartin%2C+W+G%3BBanks%2C+MA&rft.aulast=Castranova&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: APS Subscription, 9650 Rockville Pike, Bethesda, MD 20814, USA, The Physiologist, ISSN: 0031-9376, Vol 33, No 4, August 1990, abstracts: $25.00 & single issue $5.00; subscription: $25.00/yr in US & $35.00 elsewhere Paper No. 90.2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Individualization of dose: Development of dosing recommendations based upon patient factor analysis, a worthy goal of drug development AN - 41556103; 2417541 AU - Peck, C C AU - Bashaw, D AU - Dockens, R AU - Harter, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41556103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Individualization+of+dose%3A+Development+of+dosing+recommendations+based+upon+patient+factor+analysis%2C+a+worthy+goal+of+drug+development&rft.au=Peck%2C+C+C%3BBashaw%2C+D%3BDockens%2C+R%3BHarter%2C+J&rft.aulast=Peck&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Ms. Elaine Galasso, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Telephone: (215) 825-3838. Fax: (215) 834-8652., Poster Paper No. PI-6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptosis induction after silica inhalation in rats AN - 41552584; 3459385 AU - Suarez, F AU - Porter, D W AU - Mercer, R AU - Millecchia, L AU - Castranova, V AU - Ramsey, D AU - Khan, A AU - McLaurin, J L AU - Teass, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41552584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Apoptosis+induction+after+silica+inhalation+in+rats&rft.au=Suarez%2C+F%3BPorter%2C+D+W%3BMercer%2C+R%3BMillecchia%2C+L%3BCastranova%2C+V%3BRamsey%2C+D%3BKhan%2C+A%3BMcLaurin%2C+J+L%3BTeass%2C+A&rft.aulast=Suarez&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 617 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PK/PD consideration in renal and hepatic impairment studies: A regulatory perspective AN - 41552382; 3453990 AU - Mehta, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41552382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PK%2FPD+consideration+in+renal+and+hepatic+impairment+studies%3A+A+regulatory+perspective&rft.au=Mehta%2C+M&rft.aulast=Mehta&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Clinical Pharmacology and Therapeutics, 117 West Ridge Pike, Suite 2, Conshohocken, PA 19428-1216, USA; phone: 610-825-3838; fax: 610-834-8652; email: ascpt@aol.com; URL: www.ascpt.org, Abstracts available. Price $20. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transforming activity of DNA sequences of HHV-6 (GD strain) isolated from a patient with chronic fatigue syndrome AN - 41547925; 2438943 AU - Wang, J AU - Luka, J AU - Razzaque, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41547925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transforming+activity+of+DNA+sequences+of+HHV-6+%28GD+strain%29+isolated+from+a+patient+with+chronic+fatigue+syndrome&rft.au=Wang%2C+J%3BLuka%2C+J%3BRazzaque%2C+A&rft.aulast=Wang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15E, 1991; ISSN: 0730-2312 Poster Paper No. M 443 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New issues in cancer risk assessment AN - 41542905; 3421591 AU - Gaylor, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41542905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+issues+in+cancer+risk+assessment&rft.au=Gaylor%2C+D&rft.aulast=Gaylor&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: University of Arkansas for Medical Sciences (UAMS), Division of Toxicology, 4301 W. Markham Slot 638-I, Little Rock, AR 72205, USA, Abstracts available. Contact UAMS for price. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LFA-3, CD44 and CD45: Physiologic triggers of human monocyte TNF and IL-1 release AN - 41533788; 2352459 AU - Webb, DSA AU - Shimizu, Y AU - Van Seventer, GA AU - Shaw, S AU - Gerrard, T L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41533788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=LFA-3%2C+CD44+and+CD45%3A+Physiologic+triggers+of+human+monocyte+TNF+and+IL-1+release&rft.au=Webb%2C+DSA%3BShimizu%2C+Y%3BVan+Seventer%2C+GA%3BShaw%2C+S%3BGerrard%2C+T+L&rft.aulast=Webb&rft.aufirst=DSA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th floor, 605 Thrid Avenue, New York, NY 10158, USA, Journal of Leukocyte Biology, Supplement 1, 1990, ISSN: 0741-5400 Paper No. 66 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Botanic garden horticultural worker exposure to pesticides AN - 41527803; 2288928 AU - Crandall AU - Reh, C M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41527803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Botanic+garden+horticultural+worker+exposure+to+pesticides&rft.au=Crandall%3BReh%2C+C+M&rft.aulast=Crandall&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Formaldehyde exposures resulting from the use of formaldehyde containing cabinet fumigants in the field of cosmetology AN - 41526007; 2298377 AU - Almauger, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41526007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Formaldehyde+exposures+resulting+from+the+use+of+formaldehyde+containing+cabinet+fumigants+in+the+field+of+cosmetology&rft.au=Almauger%2C+D&rft.aulast=Almauger&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Method evaluation of NIOSH method for determining 4,4'-MDA in air and comparison to OSHA method 57 and NIOSH P&CAM 142 AN - 41525638; 2298023 AU - Boeniger, M AU - Neumeister, C AU - Verdi, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41525638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Method+evaluation+of+NIOSH+method+for+determining+4%2C4%27-MDA+in+air+and+comparison+to+OSHA+method+57+and+NIOSH+P%26amp%3BCAM+142&rft.au=Boeniger%2C+M%3BNeumeister%2C+C%3BVerdi%2C+J&rft.aulast=Boeniger&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 251 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microorganism contamination of HVAC humidification system - a case study AN - 41520567; 2297272 AU - Burkhart, JE AU - Stanevich, R AU - Kovak, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41520567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microorganism+contamination+of+HVAC+humidification+system+-+a+case+study&rft.au=Burkhart%2C+JE%3BStanevich%2C+R%3BKovak%2C+B&rft.aulast=Burkhart&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 120 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of exposures to fifteen substances or classes of substances in diesel-engine exhaust emissions found in three types of operations AN - 41519378; 2298380 AU - Blade, L M AU - Zaebst, D D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41519378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+exposures+to+fifteen+substances+or+classes+of+substances+in+diesel-engine+exhaust+emissions+found+in+three+types+of+operations&rft.au=Blade%2C+L+M%3BZaebst%2C+D+D&rft.aulast=Blade&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity of antibody response to group C meningococcal polysaccharide AN - 41519323; 2315089 AU - Arakere, G AU - Frasch, CE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41519323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Specificity+of+antibody+response+to+group+C+meningococcal+polysaccharide&rft.au=Arakere%2C+G%3BFrasch%2C+CE&rft.aulast=Arakere&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Avenue, N.W., Washington, DC 20005, USA. Telephone: (202) 737-3600., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adriamycin exposure assessment study among health care personnel AN - 41518949; 2297436 AU - Stephenson, R L AU - Rice, CH AU - Dimos, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41518949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adriamycin+exposure+assessment+study+among+health+care+personnel&rft.au=Stephenson%2C+R+L%3BRice%2C+CH%3BDimos%2C+J&rft.aulast=Stephenson&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 166 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fiber aerosol penetration through respirator filter media AN - 41518807; 2297351 AU - Stevens, G A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41518807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Fiber+aerosol+penetration+through+respirator+filter+media&rft.au=Stevens%2C+G+A&rft.aulast=Stevens&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 137 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Separation of aerosol change and relative humidity effects on the performance of respirator filters AN - 41516855; 2297354 AU - Stevens, G A AU - Moyer, E S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41516855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Separation+of+aerosol+change+and+relative+humidity+effects+on+the+performance+of+respirator+filters&rft.au=Stevens%2C+G+A%3BMoyer%2C+E+S&rft.aulast=Stevens&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 138 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Implementation of an experimental design approach to exposure assessment AN - 41516597; 2298301 AU - Hornung, R W AU - Herrick, R F AU - Stewart, P A AU - Hayes, R AU - Blair, A AU - Feigley, CE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41516597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Implementation+of+an+experimental+design+approach+to+exposure+assessment&rft.au=Hornung%2C+R+W%3BHerrick%2C+R+F%3BStewart%2C+P+A%3BHayes%2C+R%3BBlair%2C+A%3BFeigley%2C+CE&rft.aulast=Hornung&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 329 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Industrial hygiene characterization of carbon monoxide exposures of bridge and tunnel workers in NYC AN - 41516340; 2298185 AU - Ringenburg, V L AU - McCammon, C S AU - Stern, F B AU - Lee, ST Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41516340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Industrial+hygiene+characterization+of+carbon+monoxide+exposures+of+bridge+and+tunnel+workers+in+NYC&rft.au=Ringenburg%2C+V+L%3BMcCammon%2C+C+S%3BStern%2C+F+B%3BLee%2C+ST&rft.aulast=Ringenburg&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 290 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selected antibodies to leukocyte common antigen (CD45) inhibit neutrophil chemotaxis to leukotriene B sub(4) AN - 41511882; 2284279 AU - Harvath, L AU - Balke, JA AU - Russell, A A AU - Skubitz, K M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41511882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selected+antibodies+to+leukocyte+common+antigen+%28CD45%29+inhibit+neutrophil+chemotaxis+to+leukotriene+B+sub%284%29&rft.au=Harvath%2C+L%3BBalke%2C+JA%3BRussell%2C+A+A%3BSkubitz%2C+K+M&rft.aulast=Harvath&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conservation of the neutralization epitope of the V3 region of human immunodeficiency virus type 1 sub(MN) envelope protein in different countries AN - 41508747; 2312966 AU - Vujcic, L K AU - Carrow, E AU - Glass, W AU - Seamon, K AU - Quinn, T AU - Galvao, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41508747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Conservation+of+the+neutralization+epitope+of+the+V3+region+of+human+immunodeficiency+virus+type+1+sub%28MN%29+envelope+protein+in+different+countries&rft.au=Vujcic%2C+L+K%3BCarrow%2C+E%3BGlass%2C+W%3BSeamon%2C+K%3BQuinn%2C+T%3BGalvao%2C+F&rft.aulast=Vujcic&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Avenue, N.W., Washington, DC 20005, USA. Telephone: (202) 737-3600., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Negative impact of granulocyte-macrophage colony-stimulating factor and interleukin-3 on the phagocytic capacity of monocytes AN - 41508535; 2313152 AU - Abrahamsen, T G AU - Mertins, S AU - Carter, C S AU - Rubin, M AU - Read, E J AU - Hoffman, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41508535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Negative+impact+of+granulocyte-macrophage+colony-stimulating+factor+and+interleukin-3+on+the+phagocytic+capacity+of+monocytes&rft.au=Abrahamsen%2C+T+G%3BMertins%2C+S%3BCarter%2C+C+S%3BRubin%2C+M%3BRead%2C+E+J%3BHoffman%2C+T&rft.aulast=Abrahamsen&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Avenue, N.W., Washington, DC 20005, USA. Telephone: (202) 737-3600., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survey of toxic gas detection system users in the semiconductor industry AN - 41507428; 2297110 AU - Sussell, AL AU - Zellers, E T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41507428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Survey+of+toxic+gas+detection+system+users+in+the+semiconductor+industry&rft.au=Sussell%2C+AL%3BZellers%2C+E+T&rft.aulast=Sussell&rft.aufirst=AL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of FGF receptor in tumor cell lines AN - 41505683; 2293003 AU - Ruta, M AU - Neiger, N AU - King, C R AU - Epstein, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41505683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+FGF+receptor+in+tumor+cell+lines&rft.au=Ruta%2C+M%3BNeiger%2C+N%3BKing%2C+C+R%3BEpstein%2C+J&rft.aulast=Ruta&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Foundation for Advanced Cancer Studies N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Silica exposure in selected coal mines AN - 41505352; 2298389 AU - Kovak, B AU - Hearl, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41505352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Silica+exposure+in+selected+coal+mines&rft.au=Kovak%2C+B%3BHearl%2C+F&rft.aulast=Kovak&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BRCA-1 haplotype determination in a breast cancer case-control study AN - 41499640; 3417269 AU - Weston, A AU - Soucek, P AU - Wolff AU - Morabia, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41499640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=BRCA-1+haplotype+determination+in+a+breast+cancer+case-control+study&rft.au=Weston%2C+A%3BSoucek%2C+P%3BWolff%3BMorabia%2C+A&rft.aulast=Weston&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. Price $41.25. Poster Paper No. 500 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epstein-Barr virus infection occurs at a high percentage in human IgE producing B lymphocytes AN - 41497902; 3432756 AU - Rivera, CE AU - Mostowski, H AU - Max, EE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41497902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Epstein-Barr+virus+infection+occurs+at+a+high+percentage+in+human+IgE+producing+B+lymphocytes&rft.au=Rivera%2C+CE%3BMostowski%2C+H%3BMax%2C+EE&rft.aulast=Rivera&rft.aufirst=CE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 2236 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of morphine on lymphocyte activation pathways AN - 41492947; 2281610 AU - Taplits, M AU - Jessop, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41492947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+morphine+on+lymphocyte+activation+pathways&rft.au=Taplits%2C+M%3BJessop%2C+J&rft.aulast=Taplits&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of IL-1 production by extracts of selected organic dusts AN - 41491294; 2272425 AU - Lewis, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41491294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+IL-1+production+by+extracts+of+selected+organic+dusts&rft.au=Lewis%2C+D+M&rft.aulast=Lewis&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity of human anti-morphine antibodies in workers occupationally exposed to opiates at an ethical narcotics manufacturing facility AN - 41488985; 2278184 AU - Biagini, R E AU - Henningsen, G M AU - Klincewitcz, S L AU - Mackenzie, BA AU - Janney, MJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41488985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Specificity+of+human+anti-morphine+antibodies+in+workers+occupationally+exposed+to+opiates+at+an+ethical+narcotics+manufacturing+facility&rft.au=Biagini%2C+R+E%3BHenningsen%2C+G+M%3BKlincewitcz%2C+S+L%3BMackenzie%2C+BA%3BJanney%2C+MJ&rft.aulast=Biagini&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of calcium on regulated secretion in a murine helper T cell clone AN - 41487901; 2281313 AU - Johnson, S AU - Hoffman, T AU - Taplits, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41487901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+calcium+on+regulated+secretion+in+a+murine+helper+T+cell+clone&rft.au=Johnson%2C+S%3BHoffman%2C+T%3BTaplits%2C+M&rft.aulast=Johnson&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of dietary copper and tin on rat hepatocellular antioxidant protection AN - 41486403; 2226891 AU - Hathcock, J N AU - Reicks, M AU - Rader, JI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41486403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+dietary+copper+and+tin+on+rat+hepatocellular+antioxidant+protection&rft.au=Hathcock%2C+J+N%3BReicks%2C+M%3BRader%2C+JI&rft.aulast=Hathcock&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of HIV-1 inactivation by recombinant CD4: Saturation of gp120 receptors is not required AN - 41483777; 2280586 AU - Berkower, I AU - Murphy, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41483777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanism+of+HIV-1+inactivation+by+recombinant+CD4%3A+Saturation+of+gp120+receptors+is+not+required&rft.au=Berkower%2C+I%3BMurphy%2C+D&rft.aulast=Berkower&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 1864 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Professional activities and industrial distribution of occupational safety and health professionals in the 1980's AN - 41482850; 2297160 AU - Pedersen, D H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41482850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Professional+activities+and+industrial+distribution+of+occupational+safety+and+health+professionals+in+the+1980%27s&rft.au=Pedersen%2C+D+H&rft.aulast=Pedersen&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of polyclonal B cell activation and (auto) antigen-specific stimulation in murine lupus AN - 41482505; 2284011 AU - Klinman, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41482505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+polyclonal+B+cell+activation+and+%28auto%29+antigen-specific+stimulation+in+murine+lupus&rft.au=Klinman%2C+D+M&rft.aulast=Klinman&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Job exposure matrix for identification of exposures in occupational settings AN - 41481421; 2297394 AU - Sieber, WK Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41481421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Job+exposure+matrix+for+identification+of+exposures+in+occupational+settings&rft.au=Sieber%2C+WK+Jr&rft.aulast=Sieber&rft.aufirst=WK&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 151 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental evaluation of aerosols formed in dairy barns from the use of bedding choppers AN - 41481109; 2289276 AU - Piacitelli, LA AU - Olenchock, SA AU - Sorenson, W G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41481109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Environmental+evaluation+of+aerosols+formed+in+dairy+barns+from+the+use+of+bedding+choppers&rft.au=Piacitelli%2C+LA%3BOlenchock%2C+SA%3BSorenson%2C+W+G&rft.aulast=Piacitelli&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Paper No. 61 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selection of radiofrequency radiation control measures for dielectric heaters in the waterbed industry AN - 41480356; 2297977 AU - Murray, W E AU - Cox, C AU - Conover, D L AU - Edwards, R M AU - Werren, D M AU - Smith, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41480356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selection+of+radiofrequency+radiation+control+measures+for+dielectric+heaters+in+the+waterbed+industry&rft.au=Murray%2C+W+E%3BCox%2C+C%3BConover%2C+D+L%3BEdwards%2C+R+M%3BWerren%2C+D+M%3BSmith%2C+J+M&rft.aulast=Murray&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Industrial Hygiene Association, 345 White Pond Drive, P.O. Box 8390, Akron, OH 44320, USA, Abstracts, $35.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Modernization Act and its effect on defibrillator technology AN - 41473244; 3391538 AU - Callahan, T J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41473244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=FDA+Modernization+Act+and+its+effect+on+defibrillator+technology&rft.au=Callahan%2C+T+J&rft.aulast=Callahan&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for Advancement of Medical Instrumentation, 3330 Washington Boulevard, Suite 400, Arlington, VA 22201-4598, USA, Abstracts available. Price $75. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morphological effect of carotenoids in livers of choline-deficient rats AN - 41472146; 2255658 AU - Sheikh, N M AU - Jenkins, MY AU - Carter, C J AU - Mitchell, G V AU - Grundel, E AU - Blakely Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41472146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Morphological+effect+of+carotenoids+in+livers+of+choline-deficient+rats&rft.au=Sheikh%2C+N+M%3BJenkins%2C+MY%3BCarter%2C+C+J%3BMitchell%2C+G+V%3BGrundel%2C+E%3BBlakely&rft.aulast=Sheikh&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of dietary carotenoids on biochemical changes in rats fed a choline-deficient diet AN - 41471146; 2255655 AU - Jenkins, MY AU - Mitchell, G V AU - Grundel, E AU - Blakely Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41471146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+dietary+carotenoids+on+biochemical+changes+in+rats+fed+a+choline-deficient+diet&rft.au=Jenkins%2C+MY%3BMitchell%2C+G+V%3BGrundel%2C+E%3BBlakely&rft.aulast=Jenkins&rft.aufirst=MY&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue distribution and excretion of 14C-labeled cinnamic aldehyde following acute subacute oral administration in male Fischer-344 rats AN - 41466553; 2188810 AU - Sapienza, P P AU - Ikeda, G J AU - Warr, P I AU - Dailey, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41466553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tissue+distribution+and+excretion+of+14C-labeled+cinnamic+aldehyde+following+acute+subacute+oral+administration+in+male+Fischer-344+rats&rft.au=Sapienza%2C+P+P%3BIkeda%2C+G+J%3BWarr%2C+P+I%3BDailey%2C+R+E&rft.aulast=Sapienza&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. Telephone: 202-293-5935. Fax: 202-371-1090., Poster Paper No. 945 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Taurine does not attenuate isotretinoin toxicity in cultured organogenesis-staged rat embryos AN - 41456823; 2189657 AU - Flynn, T J AU - Gibson, R R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41456823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Taurine+does+not+attenuate+isotretinoin+toxicity+in+cultured+organogenesis-staged+rat+embryos&rft.au=Flynn%2C+T+J%3BGibson%2C+R+R&rft.aulast=Flynn&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. Telephone: 202-293-5935. Fax: 202-371-1090., Poster Paper No. 1098 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibitory action of bisbenzylisoquinoline alkaloids on the phagocytotic potential of alveolar macrophages: Usefulness as a screen for antifibrotic potency AN - 41449568; 2189714 AU - Kang, J H AU - Ma, JKH AU - Ma, JYC AU - Malanga, C J AU - Mo, C G AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41449568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibitory+action+of+bisbenzylisoquinoline+alkaloids+on+the+phagocytotic+potential+of+alveolar+macrophages%3A+Usefulness+as+a+screen+for+antifibrotic+potency&rft.au=Kang%2C+J+H%3BMa%2C+JKH%3BMa%2C+JYC%3BMalanga%2C+C+J%3BMo%2C+C+G%3BCastranova%2C+V&rft.aulast=Kang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. 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Fax: 202-371-1090., Poster Paper No. 1108 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA'S perspective on human factors engineering AN - 41448503; 3391552 AU - Sawyer, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41448503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=FDA%27S+perspective+on+human+factors+engineering&rft.au=Sawyer%2C+D&rft.aulast=Sawyer&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for Advancement of Medical Instrumentation, 3330 Washington Boulevard, Suite 400, Arlington, VA 22201-4598, USA, Abstracts available. Price $75. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of graded dietary levels of Spirulina maxima on vitamins A and E status of male rats AN - 41447060; 2255601 AU - Mitchell, G AU - Grundel, E AU - Jenkins, MY AU - Blakely Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41447060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Influence+of+graded+dietary+levels+of+Spirulina+maxima+on+vitamins+A+and+E+status+of+male+rats&rft.au=Mitchell%2C+G%3BGrundel%2C+E%3BJenkins%2C+MY%3BBlakely&rft.aulast=Mitchell&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA strand breaks induced by freshly fractured silica: Possible role of hydroxyl radical AN - 41443294; 2186208 AU - Vallyathan, V AU - Dalal, N S AU - Shi, X AU - Nguyen, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41443294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=DNA+strand+breaks+induced+by+freshly+fractured+silica%3A+Possible+role+of+hydroxyl+radical&rft.au=Vallyathan%2C+V%3BDalal%2C+N+S%3BShi%2C+X%3BNguyen%2C+M&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. 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Fax: 202-371-1090., Poster Paper No. 475 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of ornithine decarboxylase activity by 4,4'-methylene-bis(2-chloroaniline) (MOCA) in the rat AN - 41442074; 2187971 AU - Weigel, W W AU - Savage, RE Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41442074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+ornithine+decarboxylase+activity+by+4%2C4%27-methylene-bis%282-chloroaniline%29+%28MOCA%29+in+the+rat&rft.au=Weigel%2C+W+W%3BSavage%2C+RE+Jr&rft.aulast=Weigel&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. 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Fax: 202-371-1090., Poster Paper No. 760 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lymphatic fatty acid and cholesterol absorption in wheat- or oat bran-fed rats AN - 41441263; 2232326 AU - Reicks, M AU - Satchithanandam, S AU - Calvert, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41441263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lymphatic+fatty+acid+and+cholesterol+absorption+in+wheat-+or+oat+bran-fed+rats&rft.au=Reicks%2C+M%3BSatchithanandam%2C+S%3BCalvert%2C+R+J&rft.aulast=Reicks&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Standards and the 1997 FDA Modernization Act (FDAMA) AN - 41434801; 3391462 AU - Furfine, C S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41434801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Standards+and+the+1997+FDA+Modernization+Act+%28FDAMA%29&rft.au=Furfine%2C+C+S&rft.aulast=Furfine&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for Advancement of Medical Instrumentation, 3330 Washington Boulevard, Suite 400, Arlington, VA 22201-4598, USA, Abstracts available. Price $75. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKC- and IL-3 regulate actin cytoskeleton rearrangements associated with the effects on cell cycle by two distinct pathways: PKC-d dominates over IL-3 signal AN - 41434390; 3380953 AU - Romanova, L AU - Alexandrov, I AU - Nguyen, M AU - Nordan, R AU - Trepel, J AU - Mushinski, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41434390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PKC-+and+IL-3+regulate+actin+cytoskeleton+rearrangements+associated+with+the+effects+on+cell+cycle+by+two+distinct+pathways%3A+PKC-d+dominates+over+IL-3+signal&rft.au=Romanova%2C+L%3BAlexandrov%2C+I%3BNguyen%2C+M%3BNordan%2C+R%3BTrepel%2C+J%3BMushinski%2C+F&rft.aulast=Romanova&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 543 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple resistance patterns of Salmonella isolates of veterinary origin AN - 41429539; 3365822 AU - Miller, MA AU - Fedorka-Cray, P J AU - Toelle, V AU - Hollinger, K AU - Tollefson, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41429539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Multiple+resistance+patterns+of+Salmonella+isolates+of+veterinary+origin&rft.au=Miller%2C+MA%3BFedorka-Cray%2C+P+J%3BToelle%2C+V%3BHollinger%2C+K%3BTollefson%2C+L&rft.aulast=Miller&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA; phone: (404) 639-3311; URL: http://www.cdc.gov, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of glutathione in MPP super(+) and HgCl sub(2) toxicity in PC-12 cells AN - 41427993; 3364146 AU - Duhart, H M AU - Hussain, S AU - Slikker, W Jr AU - Ali, S F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41427993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+glutathione+in+MPP+super%28%2B%29+and+HgCl+sub%282%29+toxicity+in+PC-12+cells&rft.au=Duhart%2C+H+M%3BHussain%2C+S%3BSlikker%2C+W+Jr%3BAli%2C+S+F&rft.aulast=Duhart&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1370 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-molecular-weight carrageenan induces dose-dependent alterations in colonic mucosal thymidine kinase activity AN - 41426305; 2113378 AU - Calvert, R J AU - Satchithanandam, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41426305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=High-molecular-weight+carrageenan+induces+dose-dependent+alterations+in+colonic+mucosal+thymidine+kinase+activity&rft.au=Calvert%2C+R+J%3BSatchithanandam%2C+S&rft.aulast=Calvert&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent approaches to measuring target-tissue concentrations (c) in neurotoxicological studies AN - 41424939; 3363933 AU - Slikker, W Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41424939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Recent+approaches+to+measuring+target-tissue+concentrations+%28c%29+in+neurotoxicological+studies&rft.au=Slikker%2C+W+Jr&rft.aulast=Slikker&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production of interferon by alveolar macrophages and type II cells AN - 41422767; 2101252 AU - Castranova, V AU - Pailes, V H AU - Booth, JA AU - Hahon, N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Production+of+interferon+by+alveolar+macrophages+and+type+II+cells&rft.au=Castranova%2C+V%3BPailes%2C+V+H%3BBooth%2C+JA%3BHahon%2C+N&rft.aulast=Castranova&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-4 regulation of human anti-CD3 proliferative response AN - 41422741; 2099143 AU - Kozak, R W AU - Horohov, D W AU - Jones, L AU - Siegel, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IL-4+regulation+of+human+anti-CD3+proliferative+response&rft.au=Kozak%2C+R+W%3BHorohov%2C+D+W%3BJones%2C+L%3BSiegel%2C+J+P&rft.aulast=Kozak&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposure and hazard assessment of dioxins/furans via the consumption of dairy foods and fish AN - 41422600; 3364183 AU - Bolger, P M AU - Jensen, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Exposure+and+hazard+assessment+of+dioxins%2Ffurans+via+the+consumption+of+dairy+foods+and+fish&rft.au=Bolger%2C+P+M%3BJensen%2C+E&rft.aulast=Bolger&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1407 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of a commercially available in vitro stress gene assay as a rapid prescreen for compound selection to test specificity in the TG. AC mouse model AN - 41422500; 3364312 AU - Sistare, F D AU - Rosenzweig, BA AU - Hanig, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Application+of+a+commercially+available+in+vitro+stress+gene+assay+as+a+rapid+prescreen+for+compound+selection+to+test+specificity+in+the+TG.+AC+mouse+model&rft.au=Sistare%2C+F+D%3BRosenzweig%2C+BA%3BHanig%2C+J&rft.aulast=Sistare&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1536 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recovery of fish oil-derived fatty acids in lymph of thoracic duct-cannulated Wistar rats AN - 41419089; 2113617 AU - Morehouse, K M AU - Reicks, M AU - Hoadley, J AU - Satchithanandam, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41419089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Recovery+of+fish+oil-derived+fatty+acids+in+lymph+of+thoracic+duct-cannulated+Wistar+rats&rft.au=Morehouse%2C+K+M%3BReicks%2C+M%3BHoadley%2C+J%3BSatchithanandam%2C+S&rft.aulast=Morehouse&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunization with monoclonal anti-idiotypic antibodies in vivo: Dramatic differences in potency AN - 41417754; 2106593 AU - Epstein, S L AU - Harvath, L AU - Reeves, J P AU - Rubinstein, L J AU - Misplon, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41417754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunization+with+monoclonal+anti-idiotypic+antibodies+in+vivo%3A+Dramatic+differences+in+potency&rft.au=Epstein%2C+S+L%3BHarvath%2C+L%3BReeves%2C+J+P%3BRubinstein%2C+L+J%3BMisplon%2C+JA&rft.aulast=Epstein&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hydrogen peroxide alters energy metabolism in alveolar type II cells AN - 41417024; 2121268 AU - LaCagnin, L B AU - Bowman, L AU - Ma, JYC AU - Miles, PR Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41417024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hydrogen+peroxide+alters+energy+metabolism+in+alveolar+type+II+cells&rft.au=LaCagnin%2C+L+B%3BBowman%2C+L%3BMa%2C+JYC%3BMiles%2C+PR&rft.aulast=LaCagnin&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vitamin and mineral supplement use among U.S. children 2-6 years of age AN - 41416917; 2108446 AU - Kim, I AU - Park, Y K AU - Moss, A AU - Yetley, E A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41416917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Vitamin+and+mineral+supplement+use+among+U.S.+children+2-6+years+of+age&rft.au=Kim%2C+I%3BPark%2C+Y+K%3BMoss%2C+A%3BYetley%2C+E+A&rft.aulast=Kim&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic instability and tumorigenic cell transformation in folate deficient Chinese hamster ovary cells AN - 41416743; 3363149 AU - Pogribna, M AU - Melnyk, S AU - Miller, B AU - Pogribny, I P AU - James, S J AU - Allaben, W T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41416743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genomic+instability+and+tumorigenic+cell+transformation+in+folate+deficient+Chinese+hamster+ovary+cells&rft.au=Pogribna%2C+M%3BMelnyk%2C+S%3BMiller%2C+B%3BPogribny%2C+I+P%3BJames%2C+S+J%3BAllaben%2C+W+T&rft.aulast=Pogribna&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 376 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role for guanyl nucleotide-binding protein(s) in regulating inositol phospholipid hydrolysis in murine, helper T cell clones AN - 41415216; 2109679 AU - Bonvini, E AU - DeBell, KE AU - Hoffman, T AU - Taplits Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41415216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+for+guanyl+nucleotide-binding+protein%28s%29+in+regulating+inositol+phospholipid+hydrolysis+in+murine%2C+helper+T+cell+clones&rft.au=Bonvini%2C+E%3BDeBell%2C+KE%3BHoffman%2C+T%3BTaplits&rft.aulast=Bonvini&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficacy of taurine and hypotaurine as hydroxyl radical scavengers AN - 41415215; 3363509 AU - Porter, D W AU - Shi, X AU - Leonard, S S AU - Vallyathan, V AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41415215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Efficacy+of+taurine+and+hypotaurine+as+hydroxyl+radical+scavengers&rft.au=Porter%2C+D+W%3BShi%2C+X%3BLeonard%2C+S+S%3BVallyathan%2C+V%3BCastranova%2C+V&rft.aulast=Porter&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 736 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential desensitization of muscarinic-stimulated PI hydrolysis and norepinephrine release in PC12 cells by dbcAMP AN - 41415156; 2125883 AU - Takashima, A AU - Kenimer, J G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41415156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+desensitization+of+muscarinic-stimulated+PI+hydrolysis+and+norepinephrine+release+in+PC12+cells+by+dbcAMP&rft.au=Takashima%2C+A%3BKenimer%2C+J+G&rft.aulast=Takashima&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor necrosis factor a modulates transforming growth factor a expression following chemically-induced hepatotoxicity AN - 41414343; 3364111 AU - Gallucci, R M AU - Toriumi, W AU - Simeonova, P P AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41414343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tumor+necrosis+factor+a+modulates+transforming+growth+factor+a+expression+following+chemically-induced+hepatotoxicity&rft.au=Gallucci%2C+R+M%3BToriumi%2C+W%3BSimeonova%2C+P+P%3BLuster%2C+MI&rft.aulast=Gallucci&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1335 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunochemical characterization of group 19 pneumolysins and molecular cloning of 19F pneumolysin genes AN - 41414051; 2127479 AU - Li, J P AU - Goldman, N D AU - Li, S P AU - Lee, C-J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41414051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunochemical+characterization+of+group+19+pneumolysins+and+molecular+cloning+of+19F+pneumolysin+genes&rft.au=Li%2C+J+P%3BGoldman%2C+N+D%3BLi%2C+S+P%3BLee%2C+C-J&rft.aulast=Li&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of in vitro drug metabolism information to drug development and product labeling: An FDA perspective AN - 41413929; 3377571 AU - Honig, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41413929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Application+of+in+vitro+drug+metabolism+information+to+drug+development+and+product+labeling%3A+An+FDA+perspective&rft.au=Honig%2C+P&rft.aulast=Honig&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA; phone: (610) 825-3838; fax: (610) 834-8652; email: ASCPT@aol.com; URL: http://www.ascpt.org, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IND regulatory initiatives at FDA AN - 41413814; 3377509 AU - Lumpkin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41413814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IND+regulatory+initiatives+at+FDA&rft.au=Lumpkin%2C+M&rft.aulast=Lumpkin&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA; phone: (610) 825-3838; fax: (610) 834-8652; email: ASCPT@aol.com; URL: http://www.ascpt.org, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cis-acting regulatory sequences within a conserved intron of the segmentation gene engrailed (en) AN - 41412411; 2099207 AU - Kassis, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41412411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cis-acting+regulatory+sequences+within+a+conserved+intron+of+the+segmentation+gene+engrailed+%28en%29&rft.au=Kassis%2C+J&rft.aulast=Kassis&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Genetics Society of America, Administrative Office, 9650 Rockville Pike, Bethesda, MD 20814 (USA). N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroimmune interactions and interleukin 2 release AN - 41408431; 2104386 AU - Jessop, J J AU - Braxton, J AU - Sobotka, T J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41408431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuroimmune+interactions+and+interleukin+2+release&rft.au=Jessop%2C+J+J%3BBraxton%2C+J%3BSobotka%2C+T+J&rft.aulast=Jessop&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory mediators in cadmium-induced nephrotoxicity AN - 41407060; 3364371 AU - Matheson, J M AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41407060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inflammatory+mediators+in+cadmium-induced+nephrotoxicity&rft.au=Matheson%2C+J+M%3BLuster%2C+MI&rft.aulast=Matheson&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1595 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Beta interferon gene alleles correlate with serum IFN in goats; caseous lymphadenitis high in low IFN breed AN - 41406560; 2103747 AU - Gainer, J AU - Silverberg, A AU - Bradbury, R AU - Long-Bradley, P AU - Womack, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41406560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Beta+interferon+gene+alleles+correlate+with+serum+IFN+in+goats%3B+caseous+lymphadenitis+high+in+low+IFN+breed&rft.au=Gainer%2C+J%3BSilverberg%2C+A%3BBradbury%2C+R%3BLong-Bradley%2C+P%3BWomack%2C+J&rft.aulast=Gainer&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Young deaths with silicosis: Characteristics from national mortality data AN - 41406307; 3351966 AU - Roberts, S S AU - Castellan, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41406307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Young+deaths+with+silicosis%3A+Characteristics+from+national+mortality+data&rft.au=Roberts%2C+S+S%3BCastellan%2C+R+M&rft.aulast=Roberts&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Department C, P.O. Box 753, Waldorf, MD 20604-0753, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro percutaneous absorption of a hydrophobic compound through viable hairless guinea pig skin AN - 41404538; 2080538 AU - Bronaugh, R L AU - Collier, S W AU - Stewart, R F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41404538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+percutaneous+absorption+of+a+hydrophobic+compound+through+viable+hairless+guinea+pig+skin&rft.au=Bronaugh%2C+R+L%3BCollier%2C+S+W%3BStewart%2C+R+F&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1133 Fifteenth Street, NW, Suite 1000, Washington, DC 20005 (USA), Price: $ 20.00 + $ 3.00 for postage and handling Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Meta-analysis of the Iraqi and seychelles methylmercury studies AN - 41402926; 3362940 AU - Carrington, C D AU - Bolger, P M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41402926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Meta-analysis+of+the+Iraqi+and+seychelles+methylmercury+studies&rft.au=Carrington%2C+C+D%3BBolger%2C+P+M&rft.aulast=Carrington&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 164 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposure to diesel exhaust particles (DEP) alters the responsiveness of rats to bacterial lipopolysaccharide (LPS) insults AN - 41400685; 3364773 AU - Yang, H-M AU - Ma, JYC AU - Castranova, V AU - Barger, M W AU - Ma, JKH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41400685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Exposure+to+diesel+exhaust+particles+%28DEP%29+alters+the+responsiveness+of+rats+to+bacterial+lipopolysaccharide+%28LPS%29+insults&rft.au=Yang%2C+H-M%3BMa%2C+JYC%3BCastranova%2C+V%3BBarger%2C+M+W%3BMa%2C+JKH&rft.aulast=Yang&rft.aufirst=H-M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1996 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Representation and diversity: A Self-Assessment Module (SAM) for Ryan White CARE Act Planning Councils and Consortia AN - 41398073; 3351733 AU - Powell, A AU - Young, S AU - Conviser, R AU - Gomez, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41398073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Representation+and+diversity%3A+A+Self-Assessment+Module+%28SAM%29+for+Ryan+White+CARE+Act+Planning+Councils+and+Consortia&rft.au=Powell%2C+A%3BYoung%2C+S%3BConviser%2C+R%3BGomez%2C+M&rft.aulast=Powell&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Department C, P.O. Box 753, Waldorf, MD 20604-0753, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a colorimetric sensor strip to detect decomposition in frozen seafood AN - 41396670; 3367418 AU - Miller, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41396670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Liquid+chromatographic+method+for+fumonisin+B1+in+sorghum+syrup+and+corn-based+breakfast+cereals.&rft.au=Trucksess%2C+M+W%3BCho%2C+T+H%3BReady%2C+D+E&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2000-02-01&rft.volume=17&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: PITTCON '98, 300 Penn Center Boulevard, Suite 332, Pittsburgh, PA 15235-5503, USA, Abstracts available. Price $10 (USA); $12 (Outside USA). Poster Paper No. 1717P N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Responding to the needs of women with HIV: Title I and II of the Ryan White CARE Act - A report on progress from the field AN - 41396617; 3353225 AU - Eichler, A AU - Marconi, K AU - Lopez, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41396617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Responding+to+the+needs+of+women+with+HIV%3A+Title+I+and+II+of+the+Ryan+White+CARE+Act+-+A+report+on+progress+from+the+field&rft.au=Eichler%2C+A%3BMarconi%2C+K%3BLopez%2C+C&rft.aulast=Eichler&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Department C, P.O. Box 753, Waldorf, MD 20604-0753, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative acute toxicity of three glycol ethers in rodents exposed via drinking water AN - 41395038; 2082093 AU - Henningsen, G M AU - Sendelbach, LE AU - Braun, A G AU - Goad, MEP Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41395038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+acute+toxicity+of+three+glycol+ethers+in+rodents+exposed+via+drinking+water&rft.au=Henningsen%2C+G+M%3BSendelbach%2C+LE%3BBraun%2C+A+G%3BGoad%2C+MEP&rft.aulast=Henningsen&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1133 Fifteenth Street, NW, Suite 1000, Washington, DC 20005 (USA), Price: $ 20.00 + $ 3.00 for postage and handling Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intestinal absorption and lipoprotein transport of (n-3) docosahexaenoic acid AN - 41394760; 2113625 AU - Chen, I S AU - Satchithanandam, S AU - Irausquin, H AU - Sheppard, A J AU - Calvert, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41394760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intestinal+absorption+and+lipoprotein+transport+of+%28n-3%29+docosahexaenoic+acid&rft.au=Chen%2C+I+S%3BSatchithanandam%2C+S%3BIrausquin%2C+H%3BSheppard%2C+A+J%3BCalvert%2C+R+J&rft.aulast=Chen&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of dietary vitamin E on vitamin E utilization in rats fed casein and algal proteins AN - 41392792; 2108878 AU - Grundel, E AU - Mitchell, G V AU - Jenkins, MY Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41392792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+dietary+vitamin+E+on+vitamin+E+utilization+in+rats+fed+casein+and+algal+proteins&rft.au=Grundel%2C+E%3BMitchell%2C+G+V%3BJenkins%2C+MY&rft.aulast=Grundel&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sugar alcohols health claims - FDA case report AN - 41392736; 3371568 AU - Saltsman, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41392736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sugar+alcohols+health+claims+-+FDA+case+report&rft.au=Saltsman%2C+J&rft.aulast=Saltsman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Association of Dental Research (IADR), 1619 Duke Street, Alexandria, VA 22314, USA; fax: (703) 548-1883, Abstracts available. Price $30. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating the safety of varicella virus vaccine AN - 41391933; 3350338 AU - Salive, ME AU - Wise, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41391933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluating+the+safety+of+varicella+virus+vaccine&rft.au=Salive%2C+ME%3BWise%2C+R&rft.aulast=Salive&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Department C, P.O. Box 753, Waldorf, MD 20604-0753, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the TNF-receptors (TNFR) in carbon tetrachloride-induced liver toxicity AN - 41391871; 3364110 AU - Simeonova, P P AU - Flood, L AU - Kommineni, C AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41391871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+the+TNF-receptors+%28TNFR%29+in+carbon+tetrachloride-induced+liver+toxicity&rft.au=Simeonova%2C+P+P%3BFlood%2C+L%3BKommineni%2C+C%3BLuster%2C+MI&rft.aulast=Simeonova&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1334 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LC analysis of retinyl palmiters, all-rac-a-tocopheryl acetate and tocopherols in infant formula using matrix solid phase dispersion extraction AN - 41389740; 3367416 AU - Chase, GW Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41389740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=LC+analysis+of+retinyl+palmiters%2C+all-rac-a-tocopheryl+acetate+and+tocopherols+in+infant+formula+using+matrix+solid+phase+dispersion+extraction&rft.au=Chase%2C+GW+Jr&rft.aulast=Chase&rft.aufirst=GW&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: PITTCON '98, 300 Penn Center Boulevard, Suite 332, Pittsburgh, PA 15235-5503, USA, Abstracts available. Price $10 (USA); $12 (Outside USA). Poster Paper No. 1715P N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell conjugation with beads coated with the anti-T cell receptor antibody, 2C11-145, represents a functional T cell response AN - 41388901; 2109689 AU - DeBell, KE AU - Taplits AU - Hoffman, T AU - Bonvini, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41388901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+conjugation+with+beads+coated+with+the+anti-T+cell+receptor+antibody%2C+2C11-145%2C+represents+a+functional+T+cell+response&rft.au=DeBell%2C+KE%3BTaplits%3BHoffman%2C+T%3BBonvini%2C+E&rft.aulast=DeBell&rft.aufirst=KE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of kinesin from platelets AN - 41388277; 2060929 AU - Vargo, SA AU - Mullins, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41388277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+kinesin+from+platelets&rft.au=Vargo%2C+SA%3BMullins%2C+J+M&rft.aulast=Vargo&rft.aufirst=SA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotoxicological and behavioral assessment of 2',3'-dideoxycytidine (DDC) and thalidomide (THAL) in rhesus monkeys AN - 41386245; 3362943 AU - Patterson, T A AU - Zielinski, W L AU - Reepmeyer, J C AU - Nickols, J AU - Paule, M G AU - Slikker, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41386245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurotoxicological+and+behavioral+assessment+of+2%27%2C3%27-dideoxycytidine+%28DDC%29+and+thalidomide+%28THAL%29+in+rhesus+monkeys&rft.au=Patterson%2C+T+A%3BZielinski%2C+W+L%3BReepmeyer%2C+J+C%3BNickols%2C+J%3BPaule%2C+M+G%3BSlikker%2C+W&rft.aulast=Patterson&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 167 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dermal exposure assessment for the fragrance musk xylol AN - 41384990; 3363047 AU - Bronaugh, R L AU - Yourick, J J AU - Havery, DC Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41384990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dermal+exposure+assessment+for+the+fragrance+musk+xylol&rft.au=Bronaugh%2C+R+L%3BYourick%2C+J+J%3BHavery%2C+DC&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 274 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue retinol, alpha -tocopherol and thiobarbituric acid reactive substances levels in rats fed varied protein and vitamin A sources AN - 41383534; 2098822 AU - Jenkins, MY AU - Mitchell, G V AU - Grundel, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41383534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tissue+retinol%2C+alpha+-tocopherol+and+thiobarbituric+acid+reactive+substances+levels+in+rats+fed+varied+protein+and+vitamin+A+sources&rft.au=Jenkins%2C+MY%3BMitchell%2C+G+V%3BGrundel%2C+E&rft.aulast=Jenkins&rft.aufirst=MY&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design and conduct of ADHD drug treatment trials: Regulatory considerations AN - 41381227; 3348636 AU - Laughren, T P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41381227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Design+and+conduct+of+ADHD+drug+treatment+trials%3A+Regulatory+considerations&rft.au=Laughren%2C+T+P&rft.aulast=Laughren&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AACAP--Publications Department, 3615 Wisconsin Avenue, NW, Washington, DC 20016, Abstracts available. Price $20. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frequent rest breaks and musculoskeletal discomfort in keyboard intensive work: Preliminary results of a worksite intervention AN - 41375597; 3342542 AU - Conway, F T AU - Sauter, S L AU - Swanson, NG AU - Galinsky, T L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41375597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Frequent+rest+breaks+and+musculoskeletal+discomfort+in+keyboard+intensive+work%3A+Preliminary+results+of+a+worksite+intervention&rft.au=Conway%2C+F+T%3BSauter%2C+S+L%3BSwanson%2C+NG%3BGalinsky%2C+T+L&rft.aulast=Conway&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Human Factors and Ergonomics Society, PO Box 1369, Santa Monica, CA 90406-1369, Abstracts and selected full papers available. Price $70 plus shipping. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conducting a needs assessment: A self-assessment module for Ryan White CARE Act Planning Councils and Consortia AN - 41374244; 3351734 AU - Young, S AU - Powell, A AU - Conviser, R AU - Gomez, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41374244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Conducting+a+needs+assessment%3A+A+self-assessment+module+for+Ryan+White+CARE+Act+Planning+Councils+and+Consortia&rft.au=Young%2C+S%3BPowell%2C+A%3BConviser%2C+R%3BGomez%2C+M&rft.aulast=Young&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Department C, P.O. Box 753, Waldorf, MD 20604-0753, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral assessment of rats fed a high-carbohydrate/low-protein meal AN - 41369553; 2098563 AU - Sobotka, T AU - Brodie, R AU - Quander, Y AU - Whiteman, A AU - Kopral, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41369553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Behavioral+assessment+of+rats+fed+a+high-carbohydrate%2Flow-protein+meal&rft.au=Sobotka%2C+T%3BBrodie%2C+R%3BQuander%2C+Y%3BWhiteman%2C+A%3BKopral%2C+C&rft.aulast=Sobotka&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epilogue and questions and answers AN - 41363730; 2008294 AU - Gorham, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41363730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Epilogue+and+questions+and+answers&rft.au=Gorham%2C+J+R&rft.aulast=Gorham&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Conference proceedings will not be published N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of botulinum type A toxin neutralization on synaptosomal release of ( super(3)H)ACh AN - 41356606; 2062929 AU - Powers, L AU - Higgins, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41356606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+botulinum+type+A+toxin+neutralization+on+synaptosomal+release+of+%28+super%283%29H%29ACh&rft.au=Powers%2C+L%3BHiggins%2C+W&rft.aulast=Powers&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of changing health care delivery and payor systems on Ryan White Title II grants to states AN - 41347531; 3352227 AU - Young, S AU - McCarthy, S AU - Nelson, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41347531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Impact+of+changing+health+care+delivery+and+payor+systems+on+Ryan+White+Title+II+grants+to+states&rft.au=Young%2C+S%3BMcCarthy%2C+S%3BNelson%2C+J&rft.aulast=Young&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Department C, P.O. Box 753, Waldorf, MD 20604-0753, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA review of magnetic pulse devices for natural stimulation AN - 41346911; 2004786 AU - Frost, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41346911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=FDA+review+of+magnetic+pulse+devices+for+natural+stimulation&rft.au=Frost%2C+K&rft.aulast=Frost&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08854 (USA), IEEE Catalog NO.: 88CH2566-8. Library of Congress Catalog Card No.: 88-80177. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental assessments for animal drug products AN - 41327658; 3327632 AU - Miller, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41327658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Environmental+assessments+for+animal+drug+products&rft.au=Miller%2C+MA&rft.aulast=Miller&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Professor Arturo Anadon, Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Universidad Computense de Madrid, 28040 Madrid, Spain, Abstracts available. Price L25. Paper No. PLEN5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of Clostridium botulinum type E spores by high pressure processing AN - 41321281; 3319954 AU - Reddy, N R AU - Solomon, H M AU - Rhodehamel, E J AU - Balasubramaniam, V M AU - Fingerhut, G A AU - Palaniappan, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41321281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inactivation+of+Clostridium+botulinum+type+E+spores+by+high+pressure+processing&rft.au=Reddy%2C+N+R%3BSolomon%2C+H+M%3BRhodehamel%2C+E+J%3BBalasubramaniam%2C+V+M%3BFingerhut%2C+G+A%3BPalaniappan%2C+S&rft.aulast=Reddy&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute of Food Technologists, 221 N. LaSalle Street, Suite 300, Chicago, IL 60601, Abstracts available. Price $25 within U.S., $50 elsewhere. Paper No. 20-1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 3-Nitropropionic acid (3-NPA) produces hypothermia and inhibits histochemical labeling of succinate dehydrogenase (SDH) in rat brain AN - 41316393; 3302404 AU - Scallet, A C AU - Nony, P AU - Rountree, R L AU - Ye, X AU - Binienda, Z Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41316393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=3-Nitropropionic+acid+%283-NPA%29+produces+hypothermia+and+inhibits+histochemical+labeling+of+succinate+dehydrogenase+%28SDH%29+in+rat+brain&rft.au=Scallet%2C+A+C%3BNony%2C+P%3BRountree%2C+R+L%3BYe%2C+X%3BBinienda%2C+Z&rft.aulast=Scallet&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 79 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Baywatch - Surveillance of microbiological quality of Wellington beaches - An exercise in risk management and risk communication AN - 41314000; 3336144 AU - Palmer, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41314000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Baywatch+-+Surveillance+of+microbiological+quality+of+Wellington+beaches+-+An+exercise+in+risk+management+and+risk+communication&rft.au=Palmer%2C+S+G&rft.aulast=Palmer&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: New Zealand Water and Waste Association, PO Box 15974, New Lynn, Auckland, New Zealand, Full papers available. Price $50. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lead exposure causes altered spermiogenesis in rabbits AN - 41313627; 3304147 AU - Sharpnack, D AU - Childress, C AU - Moorman, W AU - Schrader, S AU - Chapin, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41313627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lead+exposure+causes+altered+spermiogenesis+in+rabbits&rft.au=Sharpnack%2C+D%3BChildress%2C+C%3BMoorman%2C+W%3BSchrader%2C+S%3BChapin%2C+R&rft.aulast=Sharpnack&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 1826 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two-dimensional electrophoretic analysis of myocardial proteins from lead-exposed rabbits AN - 41310154; 3303267 AU - Toraason, M AU - Moorman, W AU - Mathias, P I AU - Futz, C AU - Witzmann, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41310154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Two-dimensional+electrophoretic+analysis+of+myocardial+proteins+from+lead-exposed+rabbits&rft.au=Toraason%2C+M%3BMoorman%2C+W%3BMathias%2C+P+I%3BFutz%2C+C%3BWitzmann%2C+F&rft.aulast=Toraason&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 945 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk assessment for aflatoxin in corn and peanuts in the United States AN - 41308839; 3303199 AU - Henry, SH AU - Dinovi, MJ AU - Bowers, J C AU - Bolger, P M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41308839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Risk+assessment+for+aflatoxin+in+corn+and+peanuts+in+the+United+States&rft.au=Henry%2C+SH%3BDinovi%2C+MJ%3BBowers%2C+J+C%3BBolger%2C+P+M&rft.aulast=Henry&rft.aufirst=SH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 877 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polystyrene (PS) and polymethylmethacrylate (PMMA) particles in the mouse: Effect of particle size and composition on deposition following IP injection AN - 41308065; 3303325 AU - Umbreit, TH AU - Tomazic, V J AU - Merritt, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41308065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Polystyrene+%28PS%29+and+polymethylmethacrylate+%28PMMA%29+particles+in+the+mouse%3A+Effect+of+particle+size+and+composition+on+deposition+following+IP+injection&rft.au=Umbreit%2C+TH%3BTomazic%2C+V+J%3BMerritt%2C+K&rft.aulast=Umbreit&rft.aufirst=TH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 1003 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mercuric chloride induces apoptosis in cultured mouse lymphoma (L5178Y-R) cells AN - 41307511; 3302520 AU - Goering, P L AU - Lucas, AD AU - Thomas, D AU - Dalton, T AU - Rojko, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41307511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mercuric+chloride+induces+apoptosis+in+cultured+mouse+lymphoma+%28L5178Y-R%29+cells&rft.au=Goering%2C+P+L%3BLucas%2C+AD%3BThomas%2C+D%3BDalton%2C+T%3BRojko%2C+J&rft.aulast=Goering&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 196 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental toxicity of L-phenyl-alanine in intact Drosophila AN - 41306177; 3303646 AU - Lynch, D W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41306177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Developmental+toxicity+of+L-phenyl-alanine+in+intact+Drosophila&rft.au=Lynch%2C+D+W&rft.aulast=Lynch&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 1325 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survey of clinical pharmacology and biopharmaceutics studies submitted in new drug applications during the period of October 1994 to September 1995 AN - 41299523; 3301471 AU - Methta, MU AU - Lesko, L J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41299523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Survey+of+clinical+pharmacology+and+biopharmaceutics+studies+submitted+in+new+drug+applications+during+the+period+of+October+1994+to+September+1995&rft.au=Methta%2C+MU%3BLesko%2C+L+J&rft.aulast=Methta&rft.aufirst=MU&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-term abstinence in users of over the counter nicotine replacement AN - 41297368; 3301567 AU - Winchell, C J AU - Wright, C AU - Burke, L AU - Kramer, ED AU - Longmire, A W AU - Scheinbaum, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41297368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Long-term+abstinence+in+users+of+over+the+counter+nicotine+replacement&rft.au=Winchell%2C+C+J%3BWright%2C+C%3BBurke%2C+L%3BKramer%2C+ED%3BLongmire%2C+A+W%3BScheinbaum%2C+M+L&rft.aulast=Winchell&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PK-PD studies in new drug development: An FDA perspective AN - 41294606; 3301465 AU - Gillespie, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41294606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PK-PD+studies+in+new+drug+development%3A+An+FDA+perspective&rft.au=Gillespie%2C+W&rft.aulast=Gillespie&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nicotine replacement and myocardial infarction AN - 41294003; 3301565 AU - Kramer, ED AU - Longmire, A W AU - Ma, Z J AU - Winchell, C J AU - Wright, C AU - Scheinbaum, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41294003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Nicotine+replacement+and+myocardial+infarction&rft.au=Kramer%2C+ED%3BLongmire%2C+A+W%3BMa%2C+Z+J%3BWinchell%2C+C+J%3BWright%2C+C%3BScheinbaum%2C+M+L&rft.aulast=Kramer&rft.aufirst=ED&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electromagnetic compatibility test protocols for alternative temperature measurement devices AN - 41288970; 3320216 AU - Larkin, J W AU - Balasubramaniam, V M AU - Chandru, S AU - Stringer, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41288970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Electromagnetic+compatibility+test+protocols+for+alternative+temperature+measurement+devices&rft.au=Larkin%2C+J+W%3BBalasubramaniam%2C+V+M%3BChandru%2C+S%3BStringer%2C+L&rft.aulast=Larkin&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute of Food Technologists, 221 N. LaSalle Street, Suite 300, Chicago, IL 60601, Abstracts available. Price $25 within U.S., $50 elsewhere. Paper No. 35B-14 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of clinical pharmacology information in drug labeling AN - 41274632; 3301470 AU - Spyker, DA AU - Harvey, ED AU - Harvey, B E AU - Harvey, A M AU - Rumack, B H AU - Peck, C C AU - Atkinson, A J AU - Woosley, R L AU - Abernethy AU - Cantilena, L R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41274632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Assessment+of+clinical+pharmacology+information+in+drug+labeling&rft.au=Spyker%2C+DA%3BHarvey%2C+ED%3BHarvey%2C+B+E%3BHarvey%2C+A+M%3BRumack%2C+B+H%3BPeck%2C+C+C%3BAtkinson%2C+A+J%3BWoosley%2C+R+L%3BAbernethy%3BCantilena%2C+L+R&rft.aulast=Spyker&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New research and policy initiatives in CDER's Office of Clinical Pharmacology and Biopharmaceutics AN - 41258125; 3301458 AU - Lesko, L J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41258125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+research+and+policy+initiatives+in+CDER%27s+Office+of+Clinical+Pharmacology+and+Biopharmaceutics&rft.au=Lesko%2C+L+J&rft.aulast=Lesko&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Silicon-oxygen radicals and their role in acute silicosis AN - 41252360; 1727457 AU - Vallyathan, V AU - Shi, X AU - Dalal, N S AU - Irr, W AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41252360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Silicon-oxygen+radicals+and+their+role+in+acute+silicosis&rft.au=Vallyathan%2C+V%3BShi%2C+X%3BDalal%2C+N+S%3BIrr%2C+W%3BCastranova%2C+V&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Lung Association, 1740 Broadway, New York, NY 10019 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New food safety initiatives in CVM/FDA AN - 41247124; 1800354 AU - Fitzpatrick, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41247124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+food+safety+initiatives+in+CVM%2FFDA&rft.au=Fitzpatrick%2C+S&rft.aulast=Fitzpatrick&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Animal Science, 309 West Clark Street, Champaign, IL 61820 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary carbohydrate source and cellulose affect tissue trace minerals in weanling rats AN - 41245337; 1738450 AU - Rader, JI AU - Hight, S C AU - Capar, S G AU - Fox Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41245337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dietary+carbohydrate+source+and+cellulose+affect+tissue+trace+minerals+in+weanling+rats&rft.au=Rader%2C+JI%3BHight%2C+S+C%3BCapar%2C+S+G%3BFox&rft.aulast=Rader&rft.aufirst=JI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mercuric chloride-induced abortion in immune sensitive and resistant strains of rats AN - 41244036; 1745797 AU - Alleva AU - Joseph, X AU - Balazs, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41244036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mercuric+chloride-induced+abortion+in+immune+sensitive+and+resistant+strains+of+rats&rft.au=Alleva%3BJoseph%2C+X%3BBalazs%2C+T&rft.aulast=Alleva&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hyperalgesia and the histamine receptor AN - 41243194; 1756352 AU - Hanig, J P AU - Daugherty, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41243194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hyperalgesia+and+the+histamine+receptor&rft.au=Hanig%2C+J+P%3BDaugherty%2C+SA&rft.aulast=Hanig&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of iron-fortified bread on hematologic status of premenopausal women in Poland AN - 41235310; 1737663 AU - Kim, I AU - Lewis, C J AU - Crane, N T AU - Rafalski, H AU - Yetley, E A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41235310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+iron-fortified+bread+on+hematologic+status+of+premenopausal+women+in+Poland&rft.au=Kim%2C+I%3BLewis%2C+C+J%3BCrane%2C+N+T%3BRafalski%2C+H%3BYetley%2C+E+A&rft.aulast=Kim&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid induction of ODC activity after rats given soybean trypsin inhibitor with single meal or by gavage AN - 41230852; 1744605 AU - Geyer, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41230852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rapid+induction+of+ODC+activity+after+rats+given+soybean+trypsin+inhibitor+with+single+meal+or+by+gavage&rft.au=Geyer%2C+S+J&rft.aulast=Geyer&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inositol phospholipid hydrolysis by stimulation of T-cell antigen receptor complex in antigen-specific, murine T cell clones AN - 41229860; 1764697 AU - Bonvini, E AU - Hodes, R AU - DeBell, K AU - Hoffman, T AU - Taplits, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41229860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inositol+phospholipid+hydrolysis+by+stimulation+of+T-cell+antigen+receptor+complex+in+antigen-specific%2C+murine+T+cell+clones&rft.au=Bonvini%2C+E%3BHodes%2C+R%3BDeBell%2C+K%3BHoffman%2C+T%3BTaplits%2C+M&rft.aulast=Bonvini&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Turnover of tPA in rabbits AN - 41229055; 1729951 AU - Beebe, D AU - Aronson, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41229055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Turnover+of+tPA+in+rabbits&rft.au=Beebe%2C+D%3BAronson%2C+D&rft.aulast=Beebe&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction, persistence, and strain specificity of hemagglutinin-specific pulmonary antibodies after intragastric immunization with inactivated influenza virus vaccines AN - 41228530; 1739280 AU - Chen, K-S AU - Quinnan, GV Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41228530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction%2C+persistence%2C+and+strain+specificity+of+hemagglutinin-specific+pulmonary+antibodies+after+intragastric+immunization+with+inactivated+influenza+virus+vaccines&rft.au=Chen%2C+K-S%3BQuinnan%2C+GV+Jr&rft.aulast=Chen&rft.aufirst=K-S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Taurine uptake by rat alveolar macrophages and type II cells AN - 41227016; 1761763 AU - Banks, MA AU - Martin, W G AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41227016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Taurine+uptake+by+rat+alveolar+macrophages+and+type+II+cells&rft.au=Banks%2C+MA%3BMartin%2C+W+G%3BCastranova%2C+V&rft.aulast=Banks&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of pre-S2 region of hepatitis B surface antigen in E. coli AN - 41224141; 1753282 AU - Yu, M W AU - Shih, JW-K AU - Burstyn-Pettegrew, H AU - Chan, H W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41224141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+pre-S2+region+of+hepatitis+B+surface+antigen+in+E.+coli&rft.au=Yu%2C+M+W%3BShih%2C+JW-K%3BBurstyn-Pettegrew%2C+H%3BChan%2C+H+W&rft.aulast=Yu&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon- beta 2/B cell stimulatory factor 2/IL-6 is a growth factor for Epstein-Barr virus-infected human B cells AN - 41220206; 1732363 AU - Tosato, G AU - Jones, K D AU - Pike, SE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41220206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interferon-+beta+2%2FB+cell+stimulatory+factor+2%2FIL-6+is+a+growth+factor+for+Epstein-Barr+virus-infected+human+B+cells&rft.au=Tosato%2C+G%3BJones%2C+K+D%3BPike%2C+SE&rft.aulast=Tosato&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICRF-187 Pretreatment markedly increases the tolerated cumulative dose of doxorubicin in beagle dogs AN - 41210750; 1743777 AU - Herman, E AU - Ferrans, V AU - Hamlin, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41210750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=ICRF-187+Pretreatment+markedly+increases+the+tolerated+cumulative+dose+of+doxorubicin+in+beagle+dogs&rft.au=Herman%2C+E%3BFerrans%2C+V%3BHamlin%2C+R&rft.aulast=Herman&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Growth and feather development in quail: B vitamin deficiencies versus TVP feeding AN - 41209503; 1731995 AU - Tao, S-H AU - Fox AU - Fry, BE Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41209503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Growth+and+feather+development+in+quail%3A+B+vitamin+deficiencies+versus+TVP+feeding&rft.au=Tao%2C+S-H%3BFox%3BFry%2C+BE+Jr&rft.aulast=Tao&rft.aufirst=S-H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Binding characteristics and protective immunity of monoclonal antibodies to pneumococcal type 9V conjugate AN - 41204521; 3246655 AU - Lee, C AU - Wang, T AU - Kosaka, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41204521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Binding+characteristics+and+protective+immunity+of+monoclonal+antibodies+to+pneumococcal+type+9V+conjugate&rft.au=Lee%2C+C%3BWang%2C+T%3BKosaka%2C+T&rft.aulast=Lee&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 472 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific inhibition of graft rejection by soluble MHC superdimers AN - 41194080; 3248910 AU - Schneck, J P AU - Sechler, J AU - O'Herrin, S M AU - Bieler, J G AU - Barnes, N AU - Rosenberg, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41194080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Specific+inhibition+of+graft+rejection+by+soluble+MHC+superdimers&rft.au=Schneck%2C+J+P%3BSechler%2C+J%3BO%27Herrin%2C+S+M%3BBieler%2C+J+G%3BBarnes%2C+N%3BRosenberg%2C+A&rft.aulast=Schneck&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2729 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - B72 costimulation is required for Th2 but not Th1-mediated responses to ovalbumin AN - 41189657; 3246391 AU - Scott, DE AU - Agranovich, I AU - Golding, B AU - Golding, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41189657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=B72+costimulation+is+required+for+Th2+but+not+Th1-mediated+responses+to+ovalbumin&rft.au=Scott%2C+DE%3BAgranovich%2C+I%3BGolding%2C+B%3BGolding%2C+H&rft.aulast=Scott&rft.aufirst=DE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 208 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medical applications of ultraviolet lasers AN - 41183180; 1671165 AU - Waynant, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 8000:PHYSICS AND ASTRONOMY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41183180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Medical+applications+of+ultraviolet+lasers&rft.au=Waynant%2C+R+W&rft.aulast=Waynant&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: SPIE, P.O. Box 10, Bellingham, WA 98227 (USA); telephone (206) 676-3290, Proceedings volumes available Paper No. 894-13 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of an in vitro cardiac pulse duplicator AN - 41181569; 1607105 AU - Robinson, R A AU - Carey, R F AU - Herman, BA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41181569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+an+in+vitro+cardiac+pulse+duplicator&rft.au=Robinson%2C+R+A%3BCarey%2C+R+F%3BHerman%2C+BA&rft.aulast=Robinson&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Alliance for Engineering in Medicine and Biology, 1101 Connecticut Avenue, N.W., Washington, DC 20036 (USA). Telephone: (202) 857-1199, Abstract No. 9.6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fish species identification using computer-assisted pattern recognition with isoelectric focusing protein patterns from a World Wide Web accessible regulatory fish encyclopedia AN - 41172546; 3245517 AU - Tenge, B J AU - Dang, N-L AU - Fry, F S AU - Rogers, P L AU - Savary, W E AU - Barnett, J D AU - Wekell, M M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41172546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Fish+species+identification+using+computer-assisted+pattern+recognition+with+isoelectric+focusing+protein+patterns+from+a+World+Wide+Web+accessible+regulatory+fish+encyclopedia&rft.au=Tenge%2C+B+J%3BDang%2C+N-L%3BFry%2C+F+S%3BRogers%2C+P+L%3BSavary%2C+W+E%3BBarnett%2C+J+D%3BWekell%2C+M+M&rft.aulast=Tenge&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IFT Customer Service, 221 N. 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Paper No. 80D-3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assurance for food safety-residue analytical science AN - 41168552; 3245054 AU - O'Rangers, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41168552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Assurance+for+food+safety-residue+analytical+science&rft.au=O%27Rangers%2C+J+J&rft.aulast=O%27Rangers&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IFT Customer Service, 221 N. 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Paper No. 43-4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Offshore suspension relaying as a means of reducing levels of Vibrio vulnificus in gulf coast oysters AN - 41158672; 3245206 AU - Motes, M L AU - DePaola, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41158672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Offshore+suspension+relaying+as+a+means+of+reducing+levels+of+Vibrio+vulnificus+in+gulf+coast+oysters&rft.au=Motes%2C+M+L%3BDePaola%2C+A&rft.aulast=Motes&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IFT Customer Service, 221 N. 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Paper No. 53D-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microcomputer/flexible diskette submission--floppy diskette program development AN - 41156501; 1549170 AU - Dong, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41156501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microcomputer%2Fflexible+diskette+submission--floppy+diskette+program+development&rft.au=Dong%2C+M&rft.aulast=Dong&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Drug Information Association, P.O. 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Telephone: (215) 628-2288 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Summary and projections for the future: Implications for worldwide safety data reporting AN - 41151269; 1549179 AU - Anello, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41151269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Summary+and+projections+for+the+future%3A+Implications+for+worldwide+safety+data+reporting&rft.au=Anello%2C+C&rft.aulast=Anello&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Drug Information Association, P.O. Box 113, Maple Glen, PA 19002 (USA). Telephone: (215) 628-2288 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of neurohumoral mechanism of tubocurarine potentiation by struggling AN - 41149046; 1550120 AU - Hohmann, J R AU - Ellis, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41149046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analysis+of+neurohumoral+mechanism+of+tubocurarine+potentiation+by+struggling&rft.au=Hohmann%2C+J+R%3BEllis%2C+S&rft.aulast=Hohmann&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 6572 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coplanar PCBs and the relative contribution of coplanar PCBs, PCDDs, and PCDFs to the total 2,3,7,8-TCDD toxicity equivalents in human serum AN - 41148028; 3218568 AU - Kang, D AU - Tepper, A AU - Patterson, DG Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41148028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Single-site+methylation+within+the+p53+promoter+region+reduces+gene+expression+in+a+reporter+gene+construct%3A+possible+in+vivo+relevance+during+tumorigenesis.&rft.au=Pogribny%2C+I+P%3BPogribna%2C+M%3BChristman%2C+J+K%3BJames%2C+S+J&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2000-02-01&rft.volume=60&rft.issue=3&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society for Occupational & Environmental Health, 6728 Old McLean Village Drive, McLean, VA 22101, Expanded abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi-center study of rubber latex specific IgE antibodies among U.S. hospital personnel AN - 41147204; 3218519 AU - Kaczmarek, R G AU - Silverman, B G AU - Gross, T P AU - Hamilton, R G AU - Kessler, E AU - Arrowsmith-Lowe, J T AU - Moore, RM Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41147204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Multi-center+study+of+rubber+latex+specific+IgE+antibodies+among+U.S.+hospital+personnel&rft.au=Kaczmarek%2C+R+G%3BSilverman%2C+B+G%3BGross%2C+T+P%3BHamilton%2C+R+G%3BKessler%2C+E%3BArrowsmith-Lowe%2C+J+T%3BMoore%2C+RM+Jr&rft.aulast=Kaczmarek&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society for Occupational & Environmental Health, 6728 Old McLean Village Drive, McLean, VA 22101, Expanded abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bayesian estimation for TDM of anticancer drugs: Evaluation of different population methods AN - 41144439; 3214927 AU - Nakashima, H AU - Lieberman, R AU - Karato, A AU - Saijo, N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41144439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bayesian+estimation+for+TDM+of+anticancer+drugs%3A+Evaluation+of+different+population+methods&rft.au=Nakashima%2C+H%3BLieberman%2C+R%3BKarato%2C+A%3BSaijo%2C+N&rft.aulast=Nakashima&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PCR method for the detection of Helicobacter pylori in food products AN - 41143072; 3234832 AU - Cohen, A E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41143072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PCR+method+for+the+detection+of+Helicobacter+pylori+in+food+products&rft.au=Ball%2C+R%3BParker%2C+E+C&rft.aulast=Ball&rft.aufirst=R&rft.date=2000-02-01&rft.volume=71&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Department of Food Hygiene, PO Box 7009, Faculty of Veterinary Medicine, SLU S-750 07, Uppsala, Sweden, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of dietary uptake on chemical toxicity AN - 41135975; 3211689 AU - Hart, R W AU - Turturro, A AU - Duff, PH AU - Feuers, R J AU - Lu, Ming Hsiug AU - Leakey, JEA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41135975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Influence+of+dietary+uptake+on+chemical+toxicity&rft.au=Hart%2C+R+W%3BTurturro%2C+A%3BDuff%2C+PH%3BFeuers%2C+R+J%3BLu%2C+Ming+Hsiug%3BLeakey%2C+JEA&rft.aulast=Hart&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: National Research Centre, Professor Dr. Sameeh A. Mansour, Dokki, Cairo, Egypt Fax: (202)337-0931, Full papers available. Paper No. PL 5.1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis and characterization of a hydroxy metabolite of p-chloro-m-xylenol (PCMX) AN - 41133181; 3217084 AU - Reepmeyer, J C AU - Zielinski, W L AU - Leakey, J AU - Si, Ying Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41133181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Synthesis+and+characterization+of+a+hydroxy+metabolite+of+p-chloro-m-xylenol+%28PCMX%29&rft.au=Reepmeyer%2C+J+C%3BZielinski%2C+W+L%3BLeakey%2C+J%3BSi%2C+Ying&rft.aulast=Reepmeyer&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Pittsburgh Conference on Analytical Chemistry And Applied Spectroscopy, 300 Penn Center Boulevard, Suite 332, Pittsburgh, PA 15235, Abstracts available. Poster Paper No. 546P N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New strategies for the evaluation of the carcinogenic activities of chemicals AN - 41127487; 3211677 AU - Schwetz, BA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41127487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+strategies+for+the+evaluation+of+the+carcinogenic+activities+of+chemicals&rft.au=Schwetz%2C+BA&rft.aulast=Schwetz&rft.aufirst=BA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: National Research Centre, Professor Dr. Sameeh A. Mansour, Dokki, Cairo, Egypt Fax: (202)337-0931, Full papers available. Paper No. PL 1.1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health-related effects of insect rearing AN - 41125524; 3223088 AU - Short, S AU - Petsonk, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41125524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Health-related+effects+of+insect+rearing&rft.au=Short%2C+S%3BPetsonk%2C+L&rft.aulast=Short&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Entomological Society of America, 9301 Annapolis Road, Lanham, MD 20706, Contact individual authors concerning paper availability. Paper No. 0303 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Manganese-induced neurotoxicity: Recent advances in experimental research AN - 41123599; 3211682 AU - Ali, S F AU - Duhart, H M AU - Lipe, G W AU - Schmued, L AU - Slikker, W Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41123599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Manganese-induced+neurotoxicity%3A+Recent+advances+in+experimental+research&rft.au=Ali%2C+S+F%3BDuhart%2C+H+M%3BLipe%2C+G+W%3BSchmued%2C+L%3BSlikker%2C+W+Jr&rft.aulast=Ali&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: National Research Centre, Professor Dr. Sameeh A. Mansour, Dokki, Cairo, Egypt Fax: (202)337-0931, Full papers available. Paper No. PL 2.3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - On population pharmacokinetic model stability and performance AN - 41119030; 3214638 AU - Ette, E I AU - Sahajwalla, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41119030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=On+population+pharmacokinetic+model+stability+and+performance&rft.au=Ette%2C+E+I%3BSahajwalla%2C+C&rft.aulast=Ette&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is physical load at work reduced with increasing age? A pilot study AN - 41084173; 3191238 AU - Kilbom, A AU - Winkel, J AU - Kariqvist, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41084173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Is+physical+load+at+work+reduced+with+increasing+age%3F+A+pilot+study&rft.au=Kilbom%2C+A%3BWinkel%2C+J%3BKariqvist%2C+L&rft.aulast=Kilbom&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institut de Recherche en Sante et en Securite du Travail, Direction des Communications, 505 de Maisonneuve Boulevard, West, Montreal (Quebec) H3A 3C2, Canada, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methods for evaluating risks of non-cancer endpoints in epidemiology studies AN - 41082335; 3191912 AU - Bailer, A J AU - Stayner, L T AU - Smith, R J AU - Prince, M AU - Kuempel, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41082335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Methods+for+evaluating+risks+of+non-cancer+endpoints+in+epidemiology+studies&rft.au=Bailer%2C+A+J%3BStayner%2C+L+T%3BSmith%2C+R+J%3BPrince%2C+M%3BKuempel%2C+E&rft.aulast=Bailer&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Williams & Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Silicosis among gold-miners: Exposure-response analyses and risk assessment AN - 41081600; 3192058 AU - Steenland, K AU - Brown, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41081600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Silicosis+among+gold-miners%3A+Exposure-response+analyses+and+risk+assessment&rft.au=Steenland%2C+K%3BBrown%2C+D&rft.aulast=Steenland&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Williams & Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A study of the immunotoxic effects of lead AN - 41081531; 3192008 AU - Pinkerton, LE AU - Biagini, R AU - Ward, E AU - Hull, R D AU - Boeniger, M AU - Schnorr, T AU - Luster, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41081531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+study+of+the+immunotoxic+effects+of+lead&rft.au=Pinkerton%2C+LE%3BBiagini%2C+R%3BWard%2C+E%3BHull%2C+R+D%3BBoeniger%2C+M%3BSchnorr%2C+T%3BLuster%2C+M&rft.aulast=Pinkerton&rft.aufirst=LE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Williams & Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved differential fiber length classifier AN - 41071998; 3199062 AU - Baron, P A AU - Deye, G J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41071998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Improved+differential+fiber+length+classifier&rft.au=Baron%2C+P+A%3BDeye%2C+G+J&rft.aulast=Baron&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The American Society for Aerosol Research, Kemper Woods Center, 1330 Kemper Meadow Drive, Cincinnati, OH 45240. Ph: 513-742-2227; Fax: 513-742-3355., Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An evaluation of back injury risk among grocery warehouse workers AN - 41070099; 3201097 AU - Baron, S AU - Putz-Anderson, V AU - Waters, T AU - Hanley, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41070099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=An+evaluation+of+back+injury+risk+among+grocery+warehouse+workers&rft.au=Baron%2C+S%3BPutz-Anderson%2C+V%3BWaters%2C+T%3BHanley%2C+K&rft.aulast=Baron&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institut de Recherche en Sante et en Securite du Travail, Direction des Communications, 505 de Maisonneuve Boulevard, West, Montreal (Quebec) H3A 3C2, Canada, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of human lymphoblastoid cells expressing human cytochrome P450S or human udp-glucuronosyltransferases for mechanistic studies of human drug metabolism AN - 41068693; 3199763 AU - Frame, L T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41068693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+human+lymphoblastoid+cells+expressing+human+cytochrome+P450S+or+human+udp-glucuronosyltransferases+for+mechanistic+studies+of+human+drug+metabolism&rft.au=Frame%2C+L+T&rft.aulast=Frame&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Xenobiotics, PO Box 3, Cabin John, MD 20818, Abstracts available. Price $25. Poster Paper No. 372 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary effects on fecal mutagen production in pigs AN - 41051859; 1508139 AU - Pertel, R AU - Sellers, RL Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41051859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dietary+effects+on+fecal+mutagen+production+in+pigs&rft.au=Pertel%2C+R%3BSellers%2C+RL+Jr&rft.aulast=Pertel&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 701 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein efficiency ratios and net protein ratios of selected protein foods AN - 41045926; 1537558 AU - Grundel, E AU - Mitchell, G V AU - Jenkins, MY Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41045926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Protein+efficiency+ratios+and+net+protein+ratios+of+selected+protein+foods&rft.au=Grundel%2C+E%3BMitchell%2C+G+V%3BJenkins%2C+MY&rft.aulast=Grundel&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3341 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of the biosynthesis of C-reactive protein in hepatoma cells by a monocyte factor AN - 41045569; 1535265 AU - Goldman, N AU - Washington, G AU - Liu, T-Y Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41045569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+the+biosynthesis+of+C-reactive+protein+in+hepatoma+cells+by+a+monocyte+factor&rft.au=Goldman%2C+N%3BWashington%2C+G%3BLiu%2C+T-Y&rft.aulast=Goldman&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2763 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A 34 kilodalton GTP binding protein associated with the T cell receptor complex AN - 41043572; 1544750 AU - Laurenza, A AU - Seamon, K B AU - Berkower, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41043572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+34+kilodalton+GTP+binding+protein+associated+with+the+T+cell+receptor+complex&rft.au=Laurenza%2C+A%3BSeamon%2C+K+B%3BBerkower%2C+I&rft.aulast=Laurenza&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 5133 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of histamine releasing factor (HRF) synthesis in guinea pigs: Simultaneous production of a histamine release inhibitory factor and an inhibitor of HRF synthesis by lymphocytes AN - 41036668; 1538374 AU - Alam, R AU - Lewis, D M AU - Olenchock, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41036668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+histamine+releasing+factor+%28HRF%29+synthesis+in+guinea+pigs%3A+Simultaneous+production+of+a+histamine+release+inhibitory+factor+and+an+inhibitor+of+HRF+synthesis+by+lymphocytes&rft.au=Alam%2C+R%3BLewis%2C+D+M%3BOlenchock%2C+SA&rft.aulast=Alam&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3562 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Restoration of ability to respond to polysaccharide antigens in xid mice by neonatal priming with Id or anti-Id AN - 41035884; 1541141 AU - Stein, KE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41035884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Restoration+of+ability+to+respond+to+polysaccharide+antigens+in+xid+mice+by+neonatal+priming+with+Id+or+anti-Id&rft.au=Stein%2C+KE&rft.aulast=Stein&rft.aufirst=KE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 4127 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nephrotoxicity of cyclosporine A in pregnant, nonpregnant and fetal rats AN - 41034090; 1543639 AU - Alleva AU - Cockrell, B Y AU - Balazs, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41034090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Nephrotoxicity+of+cyclosporine+A+in+pregnant%2C+nonpregnant+and+fetal+rats&rft.au=Alleva%3BCockrell%2C+B+Y%3BBalazs%2C+T&rft.aulast=Alleva&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 4805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of modifications of the AIN-76A diet on selected nutritional parameters and incidence of pathology AN - 41030070; 1538094 AU - Mitchell, G V AU - Dua, P N AU - Jenkins, MY AU - Grundel, E AU - Arzadon, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41030070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+modifications+of+the+AIN-76A+diet+on+selected+nutritional+parameters+and+incidence+of+pathology&rft.au=Mitchell%2C+G+V%3BDua%2C+P+N%3BJenkins%2C+MY%3BGrundel%2C+E%3BArzadon%2C+J+M&rft.aulast=Mitchell&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3489 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aluminum in Total Diet Study foods and diets AN - 41029904; 1540767 AU - Pennington, JAT AU - Jones, J W AU - Vanderveen, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41029904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Aluminum+in+Total+Diet+Study+foods+and+diets&rft.au=Pennington%2C+JAT%3BJones%2C+J+W%3BVanderveen%2C+JE&rft.aulast=Pennington&rft.aufirst=JAT&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3999 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasminogen activation and platelet adhesion to biomaterials AN - 41028975; 1583921 AU - Feri, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41028975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Plasminogen+activation+and+platelet+adhesion+to+biomaterials&rft.au=Feri%2C+JE&rft.aulast=Feri&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Biomaterials, Box 49, University of Alabama School of Dentistry, Birmingham 35294, AL (USA), Poster Paper No. 126 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct effect of cocaine on the heart AN - 41028505; 1543778 AU - Herman, E H AU - Vick, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41028505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Direct+effect+of+cocaine+on+the+heart&rft.au=Herman%2C+E+H%3BVick%2C+J&rft.aulast=Herman&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 4840 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maturation of influenza virus-specific cytotoxic lymphocytes requires a lymphokine distinct from IL-2 AN - 41027075; 1535185 AU - Horohov, D W AU - Stocks, NI AU - Siegel, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41027075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Maturation+of+influenza+virus-specific+cytotoxic+lymphocytes+requires+a+lymphokine+distinct+from+IL-2&rft.au=Horohov%2C+D+W%3BStocks%2C+NI%3BSiegel%2C+J+P&rft.aulast=Horohov&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2738 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Iron nutritional status of females aged 20 to 44 yrs in Hispanic HANES AN - 41025668; 1537275 AU - Yetley, E A AU - McDowell, MA AU - Looker, A C AU - Johnson, CL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41025668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Iron+nutritional+status+of+females+aged+20+to+44+yrs+in+Hispanic+HANES&rft.au=Yetley%2C+E+A%3BMcDowell%2C+MA%3BLooker%2C+A+C%3BJohnson%2C+CL&rft.aulast=Yetley&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3266 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of zinc depletion on behavioral function in weanling rats AN - 41024566; 1537830 AU - Sobotka, T AU - Rader, J AU - Brodie, R AU - Quander, Y AU - West, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41024566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Impact+of+zinc+depletion+on+behavioral+function+in+weanling+rats&rft.au=Sobotka%2C+T%3BRader%2C+J%3BBrodie%2C+R%3BQuander%2C+Y%3BWest%2C+G&rft.aulast=Sobotka&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3417 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of buffered saline-benzyl alcohol as a storage solution for explanted bioprosthetic heart valves AN - 41023366; 1584024 AU - Hilbert, S L AU - Ferrans, V J AU - Yoganathan, A AU - Jones, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41023366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+buffered+saline-benzyl+alcohol+as+a+storage+solution+for+explanted+bioprosthetic+heart+valves&rft.au=Hilbert%2C+S+L%3BFerrans%2C+V+J%3BYoganathan%2C+A%3BJones%2C+M&rft.aulast=Hilbert&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Biomaterials, Box 49, University of Alabama School of Dentistry, Birmingham 35294, AL (USA), Poster Paper No. 202 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of serving size, food patterns and socioeconomic characteristics of diet cola consumers versus regular cola consumers AN - 41022407; 1528435 AU - Lewis, C J AU - Crane, N T AU - Hanson, E A AU - Yetley, E A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41022407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparison+of+serving+size%2C+food+patterns+and+socioeconomic+characteristics+of+diet+cola+consumers+versus+regular+cola+consumers&rft.au=Lewis%2C+C+J%3BCrane%2C+N+T%3BHanson%2C+E+A%3BYetley%2C+E+A&rft.aulast=Lewis&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 1612 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Airway epithelium modulates Na super(+)/K super(+) pumping and Na super(+)/H super(+) exchange in guinea pig trachealis AN - 41021499; 1500027 AU - Farmer, S G AU - Hay, DWP AU - Fedan, J S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41021499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Airway+epithelium+modulates+Na+super%28%2B%29%2FK+super%28%2B%29+pumping+and+Na+super%28%2B%29%2FH+super%28%2B%29+exchange+in+guinea+pig+trachealis&rft.au=Farmer%2C+S+G%3BHay%2C+DWP%3BFedan%2C+J+S&rft.aulast=Farmer&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 343 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene probe to detect hemolytic Listeria strains AN - 41011733; 1478501 AU - Datta, A R AU - Flamm, R K AU - Wentz, BA AU - Thomashow, M F AU - Hill, W E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41011733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Gene+probe+to+detect+hemolytic+Listeria+strains&rft.au=Datta%2C+A+R%3BFlamm%2C+R+K%3BWentz%2C+BA%3BThomashow%2C+M+F%3BHill%2C+W+E&rft.aulast=Datta&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publication Sales, 1913 I Street, N.W., Washington, DC 20006 (USA). Telephone: (202) 833-9680, Price: $20.00 (abstracts); $3.00 (program) Abstract No. P28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of proteolysis on pertussis toxin AN - 41009226; 1470329 AU - Hausman, S Z AU - Burns, D L AU - Manclark, C R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41009226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+proteolysis+on+pertussis+toxin&rft.au=Hausman%2C+S+Z%3BBurns%2C+D+L%3BManclark%2C+C+R&rft.aulast=Hausman&rft.aufirst=S&rft.date=2000-12-31&rft.volume=20&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publication Sales, 1913 I Street, N.W., Washington, DC 20006 (USA). Telephone: (202) 833-9680, Price: $20.00 (abstracts); $3.00 (program) Abstract No. B75 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Incidence of antibiotic resistance in gram-negative bacteria from cultured catfish and aquaculture ponds AN - 41007788; 1481462 AU - McPhearson, R M AU - Zywno AU - Depaola, A AU - Motes, ML Jr AU - Guarino, A M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41007788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Incidence+of+antibiotic+resistance+in+gram-negative+bacteria+from+cultured+catfish+and+aquaculture+ponds&rft.au=McPhearson%2C+R+M%3BZywno%3BDepaola%2C+A%3BMotes%2C+ML+Jr%3BGuarino%2C+A+M&rft.aulast=McPhearson&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publication Sales, 1913 I Street, N.W., Washington, DC 20006 (USA). Telephone: (202) 833-9680, Price: $20.00 (abstracts); $3.00 (program) Abstract No. Q142 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross-reaction between Shigella species envelope proteins and HLA-B27 AN - 40999815; 1478311 AU - Raybourne, R AU - Bunning, V K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cross-reaction+between+Shigella+species+envelope+proteins+and+HLA-B27&rft.au=Raybourne%2C+R%3BBunning%2C+V+K&rft.aulast=Raybourne&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publication Sales, 1913 I Street, N.W., Washington, DC 20006 (USA). Telephone: (202) 833-9680, Price: $20.00 (abstracts); $3.00 (program) Abstract No. D143 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salmonella typhimurium suppresses the immunoglobulin A immune response of both Peyer's patch and splenic lymphocytes AN - 40991154; 1474956 AU - Wess, JA AU - Petro, T M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40991154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Salmonella+typhimurium+suppresses+the+immunoglobulin+A+immune+response+of+both+Peyer%27s+patch+and+splenic+lymphocytes&rft.au=Wess%2C+JA%3BPetro%2C+T+M&rft.aulast=Wess&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publication Sales, 1913 I Street, N.W., Washington, DC 20006 (USA). Telephone: (202) 833-9680, Price: $20.00 (abstracts); $3.00 (program) Abstract No. E55 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral infectivity of Vibrio vulnificus AN - 40986568; 1466734 AU - Reyes, AL AU - Johnson, CH AU - Spaulding, P L AU - Stelma, GN Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Oral+infectivity+of+Vibrio+vulnificus&rft.au=Reyes%2C+AL%3BJohnson%2C+CH%3BSpaulding%2C+P+L%3BStelma%2C+GN+Jr&rft.aulast=Reyes&rft.aufirst=AL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publication Sales, 1913 I Street, N.W., Washington, DC 20006 (USA). Telephone: (202) 833-9680, Price: $20.00 (abstracts); $3.00 (program) Abstract No. P12 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - System to analyze fields produced by osteogenesis devices AN - 40980990; 1397990 AU - Ho, H S AU - Kantor, G AU - Allen, S J AU - Athey, T W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40980990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=System+to+analyze+fields+produced+by+osteogenesis+devices&rft.au=Ho%2C+H+S%3BKantor%2C+G%3BAllen%2C+S+J%3BAthey%2C+T+W&rft.aulast=Ho&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Alliance for Engineering in Medicine and Biology, Suite 700, 1101 Connecticut Avenue, N.W., Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrasonic texture analysis: Tissue signatures from video data AN - 40967324; 1395359 AU - Insana, M F AU - Smith, S W AU - Carroll, BA AU - Hubbard, S M AU - Garra, B S AU - Trahey, GE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40967324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ultrasonic+texture+analysis%3A+Tissue+signatures+from+video+data&rft.au=Insana%2C+M+F%3BSmith%2C+S+W%3BCarroll%2C+BA%3BHubbard%2C+S+M%3BGarra%2C+B+S%3BTrahey%2C+GE&rft.aulast=Insana&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Alliance for Engineering in Medicine and Biology, Suite 700, 1101 Connecticut Avenue, N.W., Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemical inactivation of pertussis toxin AN - 40930941; 1256642 AU - Duncan, R C AU - Burns, D L AU - Manclark, C R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chemical+inactivation+of+pertussis+toxin&rft.au=Duncan%2C+R+C%3BBurns%2C+D+L%3BManclark%2C+C+R&rft.aulast=Duncan&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1913 I Street, N.W., Washington, DC 20006 (USA), Abstract No. B11 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum bactericidal antibodies against Neisseria meningitidis groups B, Z, and 29E measured using human and rabbit complement AN - 40929176; 1320031 AU - Mocca, L F AU - Frasch, CE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Serum+bactericidal+antibodies+against+Neisseria+meningitidis+groups+B%2C+Z%2C+and+29E+measured+using+human+and+rabbit+complement&rft.au=Mocca%2C+L+F%3BFrasch%2C+CE&rft.aulast=Mocca&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. E53 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Staphylococcal enterotoxin A increases murine resistance to Listeria monocytogenes by elevating granulocyte/macrophage progenitor levels AN - 40922645; 1323387 AU - Petro, T M AU - Smith, B G AU - Wess, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Staphylococcal+enterotoxin+A+increases+murine+resistance+to+Listeria+monocytogenes+by+elevating+granulocyte%2Fmacrophage+progenitor+levels&rft.au=Petro%2C+T+M%3BSmith%2C+B+G%3BWess%2C+JA&rft.aulast=Petro&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. E66 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitation of lipopolysaccharide (endotoxin) impurity in purified polysaccharide or protein vaccines of gram-negative bacteria by silver staining following sodium dodecyl sulfate-polyacrylamide gel electrophoresis AN - 40921188; 1324311 AU - Tsai, C-M AU - Frasch, CE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40921188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Quantitation+of+lipopolysaccharide+%28endotoxin%29+impurity+in+purified+polysaccharide+or+protein+vaccines+of+gram-negative+bacteria+by+silver+staining+following+sodium+dodecyl+sulfate-polyacrylamide+gel+electrophoresis&rft.au=Tsai%2C+C-M%3BFrasch%2C+CE&rft.aulast=Tsai&rft.aufirst=C-M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. B175 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA homology and immunological cross-reactivity between Aeromonas hydrophila cytotonic toxin and cholera toxin AN - 40920691; 1323591 AU - Schultz, A J AU - Hill, W E AU - McCardell, BA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40920691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=DNA+homology+and+immunological+cross-reactivity+between+Aeromonas+hydrophila+cytotonic+toxin+and+cholera+toxin&rft.au=Schultz%2C+A+J%3BHill%2C+W+E%3BMcCardell%2C+BA&rft.aulast=Schultz&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. B242 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship of specific virulence factors to pathogenicity in Vibrio vulnificus AN - 40911870; 1300528 AU - Stelma, GN Jr AU - Reynes, AL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Relationship+of+specific+virulence+factors+to+pathogenicity+in+Vibrio+vulnificus&rft.au=Stelma%2C+GN+Jr%3BReynes%2C+AL&rft.aulast=Stelma&rft.aufirst=GN&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1913 I Street, N.W., Washington, DC 20006 (USA), Abstract No. P3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human T cell clone specific for HBsAg is restricted to HLA-A11 and cross-reacts with A2 AN - 40908452; 1199625 AU - Jin, Y AU - Shih, J W AU - Alter, H AU - Berkower, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40908452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+T+cell+clone+specific+for+HBsAg+is+restricted+to+HLA-A11+and+cross-reacts+with+A2&rft.au=Jin%2C+Y%3BShih%2C+J+W%3BAlter%2C+H%3BBerkower%2C+I&rft.aulast=Jin&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of chromatographic data systems AN - 40906492; 1238990 AU - Papas, AN AU - Delaney, M F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40906492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+chromatographic+data+systems&rft.au=Papas%2C+AN%3BDelaney%2C+M+F&rft.aulast=Papas&rft.aufirst=AN&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Individual authors must be contacted for each paper, Abstract No. 782 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of immunity by antiidiotype in vivo: Is there a primary IgM phase? AN - 40898186; 1196887 AU - Epstein, S L AU - Kindt, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40898186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+immunity+by+antiidiotype+in+vivo%3A+Is+there+a+primary+IgM+phase%3F&rft.au=Epstein%2C+S+L%3BKindt%2C+R&rft.aulast=Epstein&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C3H 10T 1/2 cells are transformed by toxins produced by food molds of the genus Alternaria AN - 40890848; 1178634 AU - Osborne, L AU - Larkin, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40890848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=C3H+10T+1%2F2+cells+are+transformed+by+toxins+produced+by+food+molds+of+the+genus+Alternaria&rft.au=Osborne%2C+L%3BLarkin%2C+E&rft.aulast=Osborne&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of inositol phosphates on mineral utilization AN - 40888853; 1196342 AU - Tao, S-H AU - Fox AU - Phillippy, B Q AU - Fry, BE Jr AU - Johnson, M L AU - Johnston, M R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40888853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+inositol+phosphates+on+mineral+utilization&rft.au=Tao%2C+S-H%3BFox%3BPhillippy%2C+B+Q%3BFry%2C+BE+Jr%3BJohnson%2C+M+L%3BJohnston%2C+M+R&rft.aulast=Tao&rft.aufirst=S-H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design problem in ulcer prevention trials AN - 40861562; 1114038 AU - Chi, GYH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Design+problem+in+ulcer+prevention+trials&rft.au=Chi%2C+GYH&rft.aulast=Chi&rft.aufirst=GYH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infectivity and neutralizing activity in sera of patients infected with human T lymphotropic virus, type III AN - 40856125; 1109181 AU - Quinnan, G V AU - Wells, MA AU - Klutch, M AU - Moffitt, A AU - Mayner, R M AU - Phelan, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Infectivity+and+neutralizing+activity+in+sera+of+patients+infected+with+human+T+lymphotropic+virus%2C+type+III&rft.au=Quinnan%2C+G+V%3BWells%2C+MA%3BKlutch%2C+M%3BMoffitt%2C+A%3BMayner%2C+R+M%3BPhelan%2C+M&rft.aulast=Quinnan&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publications Department, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. 736 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of HLA-DR antigens with influenza A virus-specific cytotoxic-T-lymphocyte responsiveness AN - 40855686; 1110222 AU - Kiley, S C AU - Burlington, D B AU - Wells, MA AU - Mittal, K K AU - Quinnan, GV Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Association+of+HLA-DR+antigens+with+influenza+A+virus-specific+cytotoxic-T-lymphocyte+responsiveness&rft.au=Kiley%2C+S+C%3BBurlington%2C+D+B%3BWells%2C+MA%3BMittal%2C+K+K%3BQuinnan%2C+GV+Jr&rft.aulast=Kiley&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publications Department, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. 977 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective cultivation of and testing for viral antigens in endothelial cells derived from Kaposi's sarcoma lesions AN - 40854985; 1109610 AU - Mitchell, C D AU - Steis, R AU - Armstrong, G AU - Quinnan, G V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selective+cultivation+of+and+testing+for+viral+antigens+in+endothelial+cells+derived+from+Kaposi%27s+sarcoma+lesions&rft.au=Mitchell%2C+C+D%3BSteis%2C+R%3BArmstrong%2C+G%3BQuinnan%2C+G+V&rft.aulast=Mitchell&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publications Department, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. 823 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotoxic damage to nigrostriatal system following intranigral administration of the oxidative metabolites of MPTP AN - 40853862; 1130535 AU - Sun, C J AU - Richman, D J AU - Gessner, W AU - Brossi, A AU - Johannessen, J N AU - Markey, S P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurotoxic+damage+to+nigrostriatal+system+following+intranigral+administration+of+the+oxidative+metabolites+of+MPTP&rft.au=Sun%2C+C+J%3BRichman%2C+D+J%3BGessner%2C+W%3BBrossi%2C+A%3BJohannessen%2C+J+N%3BMarkey%2C+S+P&rft.aulast=Sun&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adjustment for exposure measurement errors in epidemiologic risk assessment AN - 40849060; 1114559 AU - Hornung, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40849060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adjustment+for+exposure+measurement+errors+in+epidemiologic+risk+assessment&rft.au=Hornung%2C+R+W&rft.aulast=Hornung&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on Escherichia coli K51 and K93 capsular polysaccharides (CPS) cross-reactive with Neisseria meningitidis group A CPS AN - 40848838; 1104174 AU - Guirguis, N AU - Schneerson, R AU - Bax, A AU - Egan, W AU - Robbins, J B AU - Orskov, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40848838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Studies+on+Escherichia+coli+K51+and+K93+capsular+polysaccharides+%28CPS%29+cross-reactive+with+Neisseria+meningitidis+group+A+CPS&rft.au=Guirguis%2C+N%3BSchneerson%2C+R%3BBax%2C+A%3BEgan%2C+W%3BRobbins%2C+J+B%3BOrskov%2C+F&rft.aulast=Guirguis&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publications Department, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. 70 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antibodies reactive with HTLV-III found in freezer-banked sera from children in West Africa AN - 40846444; 1105639 AU - Epstein, J S AU - Moffitt, AL AU - Mayner, R E AU - Phelan, MA AU - Meyer, B C AU - Quinnan, G V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Antibodies+reactive+with+HTLV-III+found+in+freezer-banked+sera+from+children+in+West+Africa&rft.au=Epstein%2C+J+S%3BMoffitt%2C+AL%3BMayner%2C+R+E%3BPhelan%2C+MA%3BMeyer%2C+B+C%3BQuinnan%2C+G+V&rft.aulast=Epstein&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publications Department, 1913 I Street, N.W., Washington, DC 20006 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physicochemical characteristics of polysaccharides depolymerized by ultrasonic irradiation AN - 40845506; 1104227 AU - Szu, S C AU - Schneerson, R AU - Robbins, J B AU - Zon, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Physicochemical+characteristics+of+polysaccharides+depolymerized+by+ultrasonic+irradiation&rft.au=Szu%2C+S+C%3BSchneerson%2C+R%3BRobbins%2C+J+B%3BZon%2C+G&rft.aulast=Szu&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, Publications Department, 1913 I Street, N.W., Washington, DC 20006 (USA), Poster Paper No. 80 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changing health standards for quartz: Assessing the evidence AN - 40789749; 0985943 AU - Landrigan, P J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MUTIDISCIPLINARY KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40789749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Changing+health+standards+for+quartz%3A+Assessing+the+evidence&rft.au=Landrigan%2C+P+J&rft.aulast=Landrigan&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AAAS, 1515 Massachusetts Avenue, N.W., Washington, DC 20005, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential scanning calorimetry of human albumin: Bimodality at subsaturating concentrations of ligand AN - 40788795; 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0934761 AU - Li, JPC AU - Lee, C-J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40788256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Isolation+and+characterization+of+receptor+molecules+for+pneumococcal+IgG&rft.au=Li%2C+JPC%3BLee%2C+C-J&rft.aulast=Li&rft.aufirst=JPC&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sperm velocity as a measure of the toxic effects of acute EDB exposure AN - 40783543; 0971295 AU - Schrader, S M AU - Turner, T W AU - Clapp, DE AU - Ratcliffe, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40783543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sperm+velocity+as+a+measure+of+the+toxic+effects+of+acute+EDB+exposure&rft.au=Schrader%2C+S+M%3BTurner%2C+T+W%3BClapp%2C+DE%3BRatcliffe%2C+J+M&rft.aulast=Schrader&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time, Abstract No. G6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of high affinity ( super(3)H) forskolin binding sites in rat brain membranes and S49 lymphoma membranes AN - 40781218; 0942893 AU - Seamon, K B AU - Clark, R B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+high+affinity+%28+super%283%29H%29+forskolin+binding+sites+in+rat+brain+membranes+and+S49+lymphoma+membranes&rft.au=Seamon%2C+K+B%3BClark%2C+R+B&rft.aulast=Seamon&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arachiodonic acid (20:4 omega 6) metabolism by prostaglandin synthase and lipoxygenase in stimulated rat macrophage AN - 40776466; 0941618 AU - Marshall, L AU - Becker, W AU - Hoffman, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Arachiodonic+acid+%2820%3A4+omega+6%29+metabolism+by+prostaglandin+synthase+and+lipoxygenase+in+stimulated+rat+macrophage&rft.au=Marshall%2C+L%3BBecker%2C+W%3BHoffman%2C+T&rft.aulast=Marshall&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural analysis of genes related to C-reactive protein AN - 40775052; 0939875 AU - Goldman, N AU - Lei, K-J AU - Liu, T AU - Soravia, E AU - Liu, T-Y Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+analysis+of+genes+related+to+C-reactive+protein&rft.au=Goldman%2C+N%3BLei%2C+K-J%3BLiu%2C+T%3BSoravia%2C+E%3BLiu%2C+T-Y&rft.aulast=Goldman&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum K super(+) levels and isoproterenol-induced ventricular fibrillation in heavy rats AN - 40771245; 0933214 AU - Johnson, G L AU - Ehrreich, S J AU - Joseph, X AU - Whitehurst, V AU - Balazs, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Serum+K+super%28%2B%29+levels+and+isoproterenol-induced+ventricular+fibrillation+in+heavy+rats&rft.au=Johnson%2C+G+L%3BEhrreich%2C+S+J%3BJoseph%2C+X%3BWhitehurst%2C+V%3BBalazs%2C+T&rft.aulast=Johnson&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C-reactive protein mediates the solubilization of nuclear DNA in vitro AN - 40768943; 0928808 AU - Robey, F A AU - Jones, K D AU - Steinberg, AD Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=C-reactive+protein+mediates+the+solubilization+of+nuclear+DNA+in+vitro&rft.au=Robey%2C+F+A%3BJones%2C+K+D%3BSteinberg%2C+AD&rft.aulast=Robey&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute selenium intoxication in the United States AN - 40767997; 0941088 AU - Helzlsouer, K AU - Jacobs, R AU - Morris, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Acute+selenium+intoxication+in+the+United+States&rft.au=Helzlsouer%2C+K%3BJacobs%2C+R%3BMorris%2C+S&rft.aulast=Helzlsouer&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of long term feeding of soy based diets on the pancreas of Cebus monkeys AN - 40767372; 0936694 AU - Harwood, J P AU - Ausman, L M AU - King, N W AU - Sehgal, P K AU - Nicolosi, R J AU - Liener, I E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+long+term+feeding+of+soy+based+diets+on+the+pancreas+of+Cebus+monkeys&rft.au=Harwood%2C+J+P%3BAusman%2C+L+M%3BKing%2C+N+W%3BSehgal%2C+P+K%3BNicolosi%2C+R+J%3BLiener%2C+I+E&rft.aulast=Harwood&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible mechanisms by which chlorphentermine causes phospholipidosis in rat alveolar larvage materials AN - 40766925; 0923555 AU - Miles, PR AU - Cheng, W AU - Castranova, V AU - Tucker, J AU - Reasor, MJ AU - Bowman, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Possible+mechanisms+by+which+chlorphentermine+causes+phospholipidosis+in+rat+alveolar+larvage+materials&rft.au=Miles%2C+PR%3BCheng%2C+W%3BCastranova%2C+V%3BTucker%2C+J%3BReasor%2C+MJ%3BBowman%2C+L&rft.aulast=Miles&rft.aufirst=PR&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive and normotensive rats AN - 40765954; 0930026 AU - Herman, E AU - El-Hage, A AU - Ferrans, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+ICRF-187+on+doxorubicin-induced+cardiac+and+renal+toxicity+in+spontaneously+hypertensive+and+normotensive+rats&rft.au=Herman%2C+E%3BEl-Hage%2C+A%3BFerrans%2C+V&rft.aulast=Herman&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Binding of theophylline photoaffinity label analogs to rat whole brain membranes AN - 40761792; 0930037 AU - Fedan, J S AU - Hogaboom, G K AU - Monroe, L D AU - O'Donnell, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Binding+of+theophylline+photoaffinity+label+analogs+to+rat+whole+brain+membranes&rft.au=Fedan%2C+J+S%3BHogaboom%2C+G+K%3BMonroe%2C+L+D%3BO%27Donnell%2C+J+P&rft.aulast=Fedan&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examination of certain factors which could modify isoproterenol cardiotoxicity in diabetic rats AN - 40760749; 0940908 AU - El-Hage, A AU - Herman, E AU - Whitehurst, V AU - Gudbjarnason, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Examination+of+certain+factors+which+could+modify+isoproterenol+cardiotoxicity+in+diabetic+rats&rft.au=El-Hage%2C+A%3BHerman%2C+E%3BWhitehurst%2C+V%3BGudbjarnason%2C+S&rft.aulast=El-Hage&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the epithelium in contractile responses of guinea pig isolated trachea AN - 40759566; 0902488 AU - Hay, DWP AU - Robinson, V A AU - Fleming, W W AU - Fedan, J S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+the+epithelium+in+contractile+responses+of+guinea+pig+isolated+trachea&rft.au=Hay%2C+DWP%3BRobinson%2C+V+A%3BFleming%2C+W+W%3BFedan%2C+J+S&rft.aulast=Hay&rft.aufirst=DWP&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of various organic solvent vehicles on benzo(a)pyrene metabolism in rabbit lung microsomes AN - 40755978; 0902467 AU - Kontir, D M AU - Glance, C AU - Colby, H D AU - Miles, PR Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40755978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+various+organic+solvent+vehicles+on+benzo%28a%29pyrene+metabolism+in+rabbit+lung+microsomes&rft.au=Kontir%2C+D+M%3BGlance%2C+C%3BColby%2C+H+D%3BMiles%2C+PR&rft.aulast=Kontir&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of a cysteine conjugate beta -lyase with kynureninase activity AN - 40755964; 0912716 AU - Stevens, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40755964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Isolation+of+a+cysteine+conjugate+beta+-lyase+with+kynureninase+activity&rft.au=Stevens%2C+J+L&rft.aulast=Stevens&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microbial metabolism of pyrene AN - 40754836; 0900305 AU - Cerniglia, CE AU - Kelly, D AU - Freeman, J P AU - Miller, D W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microbial+metabolism+of+pyrene&rft.au=Cerniglia%2C+CE%3BKelly%2C+D%3BFreeman%2C+J+P%3BMiller%2C+D+W&rft.aulast=Cerniglia&rft.aufirst=CE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further characterization of Mycoplasma pneumoniae extract with attachment activity AN - 40715698; 0848412 AU - Chandler, DKF AU - Razin, S AU - Grabowski, M W AU - Barile, M F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Further+characterization+of+Mycoplasma+pneumoniae+extract+with+attachment+activity&rft.au=Chandler%2C+DKF%3BRazin%2C+S%3BGrabowski%2C+M+W%3BBarile%2C+M+F&rft.aulast=Chandler&rft.aufirst=DKF&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. G 19 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased reliability in the detection of foodborne enterotoxigenic Escherichia coli by DNA colony hybridization AN - 40715661; 0843861 AU - Davis, V M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Increased+reliability+in+the+detection+of+foodborne+enterotoxigenic+Escherichia+coli+by+DNA+colony+hybridization&rft.au=Davis%2C+V+M&rft.aulast=Davis&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. P 35 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Incidence and significance of Aeromonas hydrophila along the Gulf Coast AN - 40715111; 0849011 AU - Motes, ML Jr AU - McPhearson, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Incidence+and+significance+of+Aeromonas+hydrophila+along+the+Gulf+Coast&rft.au=Motes%2C+ML+Jr%3BMcPhearson%2C+R+M&rft.aulast=Motes&rft.aufirst=ML&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. Q 107 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Foodborne enterotoxigenic Escherichia coli : Detection and enumeration on nitrocellulose membrane by enzyme immunoassay AN - 40714664; 0843855 AU - Rhea, U S AU - Shah, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Foodborne+enterotoxigenic+Escherichia+coli+%3A+Detection+and+enumeration+on+nitrocellulose+membrane+by+enzyme+immunoassay&rft.au=Rhea%2C+U+S%3BShah%2C+D+B&rft.aulast=Rhea&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. P 34 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adherence of Bordetella pertussis to human WiDr cell cultures AN - 40714419; 0842981 AU - Urisu, A AU - Cowell, J L AU - Manclark, C R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adherence+of+Bordetella+pertussis+to+human+WiDr+cell+cultures&rft.au=Urisu%2C+A%3BCowell%2C+J+L%3BManclark%2C+C+R&rft.aulast=Urisu&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. B 65 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathogenic Vibrio species, including Vibrio cholerae , from inland bays of the U.S. West Coast AN - 40713239; 0848988 AU - Kaysner, CA AU - Abeyta, C Jr AU - Wekell, M M AU - Depaola, A AU - Stott, R F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40713239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pathogenic+Vibrio+species%2C+including+Vibrio+cholerae+%2C+from+inland+bays+of+the+U.S.+West+Coast&rft.au=Kaysner%2C+CA%3BAbeyta%2C+C+Jr%3BWekell%2C+M+M%3BDepaola%2C+A%3BStott%2C+R+F&rft.aulast=Kaysner&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. Q 98 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protection against reinfection by Mycoplasma pneumoniae in chimpanzees AN - 40710945; 0848429 AU - Grabowski, M W AU - Graham, CE AU - Pollok, N L AU - Kapatais-Zoumbos, K AU - Chandler, DKF AU - Barile, M F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40710945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Protection+against+reinfection+by+Mycoplasma+pneumoniae+in+chimpanzees&rft.au=Grabowski%2C+M+W%3BGraham%2C+CE%3BPollok%2C+N+L%3BKapatais-Zoumbos%2C+K%3BChandler%2C+DKF%3BBarile%2C+M+F&rft.aulast=Grabowski&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. G 22 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of heat-stable-enterotoxin-producing Escherichia coli by using synthetic oligonucleotides AN - 40709739; 0843863 AU - Hill, W E AU - Payne, W L AU - Zon, G AU - Moseley, S L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40709739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+heat-stable-enterotoxin-producing+Escherichia+coli+by+using+synthetic+oligonucleotides&rft.au=Hill%2C+W+E%3BPayne%2C+W+L%3BZon%2C+G%3BMoseley%2C+S+L&rft.aulast=Hill&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. P 36 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mold flora of fresh tomatoes and presence of tenuazonic acid AN - 40709536; 0843734 AU - Bruce, V R AU - Mislivec, P B AU - Stack, ME Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40709536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mold+flora+of+fresh+tomatoes+and+presence+of+tenuazonic+acid&rft.au=Bruce%2C+V+R%3BMislivec%2C+P+B%3BStack%2C+ME&rft.aulast=Bruce&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. P 29 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved method for the purification of Campylobacter toxin AN - 40709232; 0847546 AU - McCardell, BA AU - Madden, J M AU - Lee, E C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40709232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Improved+method+for+the+purification+of+Campylobacter+toxin&rft.au=McCardell%2C+BA%3BMadden%2C+J+M%3BLee%2C+E+C&rft.aulast=McCardell&rft.aufirst=BA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. B 121 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fungal metabolism and detoxification of 1-nitropyrene AN - 40708762; 0840298 AU - Cerniglia, CE AU - Freeman, J P AU - Miller, D W AU - White, G AU - Heflich, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40708762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Fungal+metabolism+and+detoxification+of+1-nitropyrene&rft.au=Cerniglia%2C+CE%3BFreeman%2C+J+P%3BMiller%2C+D+W%3BWhite%2C+G%3BHeflich%2C+R&rft.aulast=Cerniglia&rft.aufirst=CE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. O 7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aeromonas hydrophila in shellfish-growing waters: Incidence and medium evaluation AN - 40707449; 0840347 AU - Abeyta, C Jr AU - Kaysner, CA AU - Wekell, M M AU - Peeler, J T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Aeromonas+hydrophila+in+shellfish-growing+waters%3A+Incidence+and+medium+evaluation&rft.au=Abeyta%2C+C+Jr%3BKaysner%2C+CA%3BWekell%2C+M+M%3BPeeler%2C+J+T&rft.aulast=Abeyta&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. Q 9 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Method for recovery of poliovirus 1 from 25-gram food samples AN - 40705873; 0845543 AU - Sullivan, R AU - Peeler, J T AU - Larkin, E P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Method+for+recovery+of+poliovirus+1+from+25-gram+food+samples&rft.au=Sullivan%2C+R%3BPeeler%2C+J+T%3BLarkin%2C+E+P&rft.aulast=Sullivan&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1985, Abstracts available: American Society for Microbiology, Publication Department,1913 I St. NW, Washington, DC 20006, USA, Paper No. Q 73 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Varicella-zoster virus (VZV)-infection of human lymphocyte subpopulations in vitro AN - 40702969; 0808629 AU - Cooper, E C AU - Vujcic, L AU - Quinnan, G V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40702969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Varicella-zoster+virus+%28VZV%29-infection+of+human+lymphocyte+subpopulations+in+vitro&rft.au=Cooper%2C+E+C%3BVujcic%2C+L%3BQuinnan%2C+G+V&rft.aulast=Cooper&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Program and Abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy", 1984, ASM Publications Office, 1913 I Street, NW, Washington, DC 20006, USA, ISBN 0-914826-67-0; ISSN 0733-6373; Price: $10.00 Abstract No. 42 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ozone enhancement of soluble platinum salt asthma in a primate model AN - 40691656; 0753932 AU - Moorman, W J AU - Biagini, R E AU - Lewis, T R AU - Bernstein, IL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40691656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ozone+enhancement+of+soluble+platinum+salt+asthma+in+a+primate+model&rft.au=Khan%2C+A+A&rft.aulast=Khan&rft.aufirst=A&rft.date=2000-01-15&rft.volume=182&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1016%2FS0378-1097%2899%2900609-6 LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1984, Abstracts booklet available: Special Publications Dep., FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, 2 vols.; Price: $25.00 Paper No. 3038 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolic oxidation of carcinogenic arylamines by hepatic microsomes and purified cytochromes P-450 AN - 40691590; 0745632 AU - Hammons, G J AU - Guengerich, F P AU - Weis, C C AU - Kadlubar, F F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40691590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metabolic+oxidation+of+carcinogenic+arylamines+by+hepatic+microsomes+and+purified+cytochromes+P-450&rft.au=Hammons%2C+G+J%3BGuengerich%2C+F+P%3BWeis%2C+C+C%3BKadlubar%2C+F+F&rft.aulast=Hammons&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1984, Abstracts booklet available: Special Publications Dep., FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, 2 vols.; Price: $25.00 Paper No. 695 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic control of induction of antinucleolar antibodies by mercuric chloride in mice AN - 40679722; 0751659 AU - Robinson, CJG AU - Egorov, I AU - Balazs, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40679722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genetic+control+of+induction+of+antinucleolar+antibodies+by+mercuric+chloride+in+mice&rft.au=Robinson%2C+CJG%3BEgorov%2C+I%3BBalazs%2C+T&rft.aulast=Robinson&rft.aufirst=CJG&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1984, Abstracts booklet available: Special Publications Dep., FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, 2 vols.; Price: $25.00 Paper No. 2354 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of chlorphentermine and phentermine on the enzymatic hydrolysis of dipalmitoyl lecithin AN - 40673200; 0742154 AU - Ma, JYC AU - Ma, JKH AU - Weber, K C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+chlorphentermine+and+phentermine+on+the+enzymatic+hydrolysis+of+dipalmitoyl+lecithin&rft.au=Ma%2C+JYC%3BMa%2C+JKH%3BWeber%2C+K+C&rft.aulast=Ma&rft.aufirst=JYC&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1984, Abstracts booklet available: Special Publications Dep., FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, 2 vols.; Price: $25.00 Paper No. 234 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Airborne endotoxins in poultry confinement units AN - 40666448; 0706061 AU - Olenchock, SA AU - Jones, W G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40666448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Airborne+endotoxins+in+poultry+confinement+units&rft.au=Olenchock%2C+SA%3BJones%2C+W+G&rft.aulast=Olenchock&rft.aufirst=SA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "American Review of Respiratory Disease", Apr. 1984, American Lung Association, 1740 Broadway, New York, NY 10019, USA, ISSN 0003-0805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracts of airborne grain dusts stimulate interleukin 1(IL-1) production by alveolar macrophages AN - 40660841; 0706035 AU - Lewis, D M AU - Mentnech Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Extracts+of+airborne+grain+dusts+stimulate+interleukin+1%28IL-1%29+production+by+alveolar+macrophages&rft.au=Lewis%2C+D+M%3BMentnech&rft.aulast=Lewis&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "American Review of Respiratory Disease", Apr. 1984, American Lung Association, 1740 Broadway, New York, NY 10019, USA, ISSN 0003-0805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of HPLC as a cleanup technique for analyzing food for contaminants by GC-MS AN - 40658098; 0698410 AU - Luchtefeld, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+HPLC+as+a+cleanup+technique+for+analyzing+food+for+contaminants+by+GC-MS&rft.au=Luchtefeld%2C+R&rft.aulast=Luchtefeld&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: "HPLC Book of Abstracts", May 1984, HPLC '84, c/o Prof. Csaba Horvath, Yale University, P.O. Box 2159, Yale Station, New Haven, CT 06520, USA, Price: $30.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternative approaches for assessing iron status AN - 40650267; 0683343 AU - Yetley, E A AU - Johnson, C AU - McDowell, M AU - Gable, C B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40650267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Alternative+approaches+for+assessing+iron+status&rft.au=Yetley%2C+E+A%3BJohnson%2C+C%3BMcDowell%2C+M%3BGable%2C+C+B&rft.aulast=Yetley&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 2224 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of benoxaprofen, diethylcarbamazine or nordihydroguaiaretic acid on isoproterenol-induced ventricular fibrillation in rats AN - 40650152; 0684710 AU - Johnson, G L AU - El-Hage, A AU - Ehrreich, S J AU - Gudbjarnason, S AU - Whitehurst, V AU - Balazs, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40650152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=654&rft.isbn=&rft.btitle=Healthy+People+2010.+Conference+Edition%3A+Partnerships+for+Health+in+the+New+Millennium.+Held+on+January+24-28%2C+2000.+Volume+2&rft.title=Healthy+People+2010.+Conference+Edition%3A+Partnerships+for+Health+in+the+New+Millennium.+Held+on+January+24-28%2C+2000.+Volume+2&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 2674 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Short-term effects of soy and zinc deficiency in newly hatched Japanese quail AN - 40649797; 0683630 AU - Fox AU - Tao, S-H AU - Stone, CL AU - Fry, BE Jr AU - Johnson, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40649797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Short-term+effects+of+soy+and+zinc+deficiency+in+newly+hatched+Japanese+quail&rft.au=Fox%3BTao%2C+S-H%3BStone%2C+CL%3BFry%2C+BE+Jr%3BJohnson%2C+M+L&rft.aulast=Fox&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 2341 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of lung unit and whole lung area-volume relationships AN - 40649608; 0686413 AU - Brancazio, L R AU - Frazer, D G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40649608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparison+of+lung+unit+and+whole+lung+area-volume+relationships&rft.au=Brancazio%2C+L+R%3BFrazer%2C+D+G&rft.aulast=Brancazio&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 3205 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cd absorption, retention, excretion and distribution patterns in adult and neonate miniature swine AN - 40648262; 0682104 AU - Sapienza, P AU - Levin, R AU - Ikeda, G AU - Miller, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40648262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cd+absorption%2C+retention%2C+excretion+and+distribution+patterns+in+adult+and+neonate+miniature+swine&rft.au=Sapienza%2C+P%3BLevin%2C+R%3BIkeda%2C+G%3BMiller%2C+E&rft.aulast=Sapienza&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 1734 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of several calcium antagonists on contractile responses produced by various agonists on rat aortic ring preparations AN - 40647714; 0680572 AU - Jones, E Jr AU - Jones, JA AU - Sun, CL AU - Garvey, H L AU - Hanig, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40647714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+several+calcium+antagonists+on+contractile+responses+produced+by+various+agonists+on+rat+aortic+ring+preparations&rft.au=Jones%2C+E+Jr%3BJones%2C+JA%3BSun%2C+CL%3BGarvey%2C+H+L%3BHanig%2C+J+P&rft.aulast=Jones&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 960 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of n-alkanes on cytochrome-P450 activities in rat liver and lung microsomes AN - 40644371; 0681842 AU - Rabovsky, J AU - Judy, D J AU - Pailes, W H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40644371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+n-alkanes+on+cytochrome-P450+activities+in+rat+liver+and+lung+microsomes&rft.au=Rabovsky%2C+J%3BJudy%2C+D+J%3BPailes%2C+W+H&rft.aulast=Rabovsky&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 1625 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer networking of microbial data in the FDA AN - 40627966; 0623162 AU - Benedict, F AU - Walczak, C AU - Portyrata, D AU - Jones, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40627966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Computer+networking+of+microbial+data+in+the+FDA&rft.au=Benedict%2C+F%3BWalczak%2C+C%3BPortyrata%2C+D%3BJones%2C+V&rft.aulast=Benedict&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: American Society for Microbiology, Publications Department, 1913 I St. NW, Washington, DC 20006, USA, Paper No. X4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ability of dialyzable tuberculins to inhibit reactivity of nondialyzable tuberculin AN - 40627901; 0622262 AU - Chaparas, S D AU - Godette, K D AU - Benton, D AU - Holobaugh, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40627901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ability+of+dialyzable+tuberculins+to+inhibit+reactivity+of+nondialyzable+tuberculin&rft.au=Chaparas%2C+S+D%3BGodette%2C+K+D%3BBenton%2C+D%3BHolobaugh%2C+P&rft.aulast=Chaparas&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: American Society for Microbiology, Publications Department, 1913 I St. NW, Washington, DC 20006, USA, Paper No. U11 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expansion of micro-IS to include plasmid coding AN - 40622937; 0623169 AU - Jones, V M AU - Tennover, F AU - Hill, W E AU - Benedict, F A AU - Krichevsky, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expansion+of+micro-IS+to+include+plasmid+coding&rft.au=Jones%2C+V+M%3BTennover%2C+F%3BHill%2C+W+E%3BBenedict%2C+F+A%3BKrichevsky%2C+MI&rft.aulast=Jones&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: American Society for Microbiology, Publications Department, 1913 I St. NW, Washington, DC 20006, USA, Paper No. X5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parvoviruses: thermal resistance AN - 40622530; 0629010 AU - Fassolitis, A C AU - Jones, VI AU - Peeler, J T AU - Larkin, E P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Parvoviruses%3A+thermal+resistance&rft.au=Fassolitis%2C+A+C%3BJones%2C+VI%3BPeeler%2C+J+T%3BLarkin%2C+E+P&rft.aulast=Fassolitis&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: American Society for Microbiology, Publications Department, 1913 I St. NW, Washington, DC 20006, USA, Paper No. S30 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Clostridium perfringens enterotoxin in stool specimens and culture supernatants by an enzyme-linked immunosorbent assay AN - 40619832; 0622482 AU - Wimsatt, J C AU - Harmon, S M AU - Shah, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40619832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+Clostridium+perfringens+enterotoxin+in+stool+specimens+and+culture+supernatants+by+an+enzyme-linked+immunosorbent+assay&rft.au=Wimsatt%2C+J+C%3BHarmon%2C+S+M%3BShah%2C+D+B&rft.aulast=Wimsatt&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: American Society for Microbiology, Publications Department, 1913 I St. NW, Washington, DC 20006, USA, Paper No. C61 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the gene encoding CMP-N-acetyl-neuraminic acid synthetase from the cloned K1 capsule genes of Escherichia coli AN - 40619363; 0627282 AU - Aaronson, W AU - Vann, W AU - Kotsatos, M AU - Silver, R P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40619363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+the+gene+encoding+CMP-N-acetyl-neuraminic+acid+synthetase+from+the+cloned+K1+capsule+genes+of+Escherichia+coli&rft.au=Aaronson%2C+W%3BVann%2C+W%3BKotsatos%2C+M%3BSilver%2C+R+P&rft.aulast=Aaronson&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts available: American Society for Microbiology, Publications Department, 1913 I St. NW, Washington, DC 20006, USA, Paper No. D99 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food chemicals codex method for mixed tocopherol: 1983 collaborative study AN - 40601817; 0558124 AU - Sheppard, A J AU - Rudolf, T S AU - Shen, C-SJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40601817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Food+chemicals+codex+method+for+mixed+tocopherol%3A+1983+collaborative+study&rft.au=Sheppard%2C+A+J%3BRudolf%2C+T+S%3BShen%2C+C-SJ&rft.aulast=Sheppard&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatographic cleanup procedure for use in confirmation of aflatoxin B sub(1) by negative ion chemical ionization (NICI) mass spectrometry AN - 40599680; 0558265 AU - Diprossimo, V P AU - Abdel-Malek, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40599680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chromatographic+cleanup+procedure+for+use+in+confirmation+of+aflatoxin+B+sub%281%29+by+negative+ion+chemical+ionization+%28NICI%29+mass+spectrometry&rft.au=Diprossimo%2C+V+P%3BAbdel-Malek%2C+E&rft.aulast=Diprossimo&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elemental determination in infant formula by inductively coupled plasma emission spectroscopy: collaborative study AN - 40599306; 0557727 AU - Suddendorf, R F AU - Cook, K K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40599306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Elemental+determination+in+infant+formula+by+inductively+coupled+plasma+emission+spectroscopy%3A+collaborative+study&rft.au=Suddendorf%2C+R+F%3BCook%2C+K+K&rft.aulast=Suddendorf&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vitamin A and vitamin E contents of infant formula produced in the United States AN - 40595080; 0557552 AU - Landen, WO Jr AU - Hines, D M AU - Hamill, T W AU - Martin, JI AU - Young, E R AU - Eitenmiller, R R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40595080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Vitamin+A+and+vitamin+E+contents+of+infant+formula+produced+in+the+United+States&rft.au=Landen%2C+WO+Jr%3BHines%2C+D+M%3BHamill%2C+T+W%3BMartin%2C+JI%3BYoung%2C+E+R%3BEitenmiller%2C+R+R&rft.aulast=Landen&rft.aufirst=WO&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Liquid chromatographic determination of aspartame in dry beverage bases and sweetener tablets with confirmation by thin layer chromatography AN - 40593104; 0557308 AU - Daniels, D H AU - Joe, FL Jr AU - Warner, C R AU - Fazio, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40593104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Liquid+chromatographic+determination+of+aspartame+in+dry+beverage+bases+and+sweetener+tablets+with+confirmation+by+thin+layer+chromatography&rft.au=Daniels%2C+D+H%3BJoe%2C+FL+Jr%3BWarner%2C+C+R%3BFazio%2C+T&rft.aulast=Daniels&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative collaborative study of the helium lake test and the vacuum leak test using canned foods AN - 40591264; 0557284 AU - Rhea, U S AU - Gilchrist, JE AU - Peeler, J T AU - Shah, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40591264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+collaborative+study+of+the+helium+lake+test+and+the+vacuum+leak+test+using+canned+foods&rft.au=Rhea%2C+U+S%3BGilchrist%2C+JE%3BPeeler%2C+J+T%3BShah%2C+D+B&rft.aulast=Rhea&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aeromonas hydrophila considered as a food borne pathogen AN - 40590257; 0557418 AU - Tsedt, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40590257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Aeromonas+hydrophila+considered+as+a+food+borne+pathogen&rft.au=Tsedt%2C+R+M&rft.aulast=Tsedt&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lymphocytes from patients with acquired immunodeficiency syndrome suppress alloantigen- but not mitogen-induced responses AN - 40589941; 0551265 AU - Wells, MA AU - Burlington, D B AU - Rook, AH AU - Frederick, W R AU - Masur, H AU - Fauci, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lymphocytes+from+patients+with+acquired+immunodeficiency+syndrome+suppress+alloantigen-+but+not+mitogen-induced+responses&rft.au=Wells%2C+MA%3BBurlington%2C+D+B%3BRook%2C+AH%3BFrederick%2C+W+R%3BMasur%2C+H%3BFauci%2C+A&rft.aulast=Wells&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: ASM, Publications Sales Dep., 1913 I Street, N.W., Washington, DC 20006, USA, Abstracts booklet: ISSN: 0733-6373; Price: $10.00 Abstract No. 957 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunogenicity of wild and attenuated varicella zoster virus in rhesus monkeys AN - 40587087; 0547206 AU - Asano, Y AU - Albrecht, P AU - Rastogi, S C AU - Vickers, J H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40587087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunogenicity+of+wild+and+attenuated+varicella+zoster+virus+in+rhesus+monkeys&rft.au=Asano%2C+Y%3BAlbrecht%2C+P%3BRastogi%2C+S+C%3BVickers%2C+J+H&rft.aulast=Asano&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: ASM, Publications Sales Dep., 1913 I Street, N.W., Washington, DC 20006, USA, Abstracts booklet: ISSN: 0733-6373; Price: $10.00 Abstract No. 398 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automated characterization of particles extracted from human lungs: three cases of tungsten carbide exposure AN - 40586704; 0565823 AU - Stettler, LE AU - Groth, D H AU - Platek, S F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 8000:PHYSICS AND ASTRONOMY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40586704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Automated+characterization+of+particles+extracted+from+human+lungs%3A+three+cases+of+tungsten+carbide+exposure&rft.au=Stettler%2C+LE%3BGroth%2C+D+H%3BPlatek%2C+S+F&rft.aulast=Stettler&rft.aufirst=LE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: "Scanning Electron Microscopy/1983/I-III", 1983, Scanning Electron Microscopy, Inc., P.O. Box 66507, AMF O'Hare (Chicago), IL 60666 USA, ISSN 0586-5581. Proceedings consists of 3 issues N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coprostanol: a promising indicator of fecal contamination of food AN - 40582927; 0557109 AU - Hoskin, G P AU - Bandler, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40582927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Coprostanol%3A+a+promising+indicator+of+fecal+contamination+of+food&rft.au=Hoskin%2C+G+P%3BBandler%2C+R&rft.aulast=Hoskin&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: AOAC, 1111 N. 19th St., Suite 210, Arlington, VA 22209, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Occurrence of Tn917-mediated MLS resistance among group D streptococci isolated from swine, broilers, and humans AN - 40578822; 0546687 AU - Rollins, L D AU - Lee, L N AU - Banai, M AU - Leblanc, D J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40578822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Occurrence+of+Tn917-mediated+MLS+resistance+among+group+D+streptococci+isolated+from+swine%2C+broilers%2C+and+humans&rft.au=Rollins%2C+L+D%3BLee%2C+L+N%3BBanai%2C+M%3BLeblanc%2C+D+J&rft.aulast=Rollins&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: ASM, Publications Sales Dep., 1913 I Street, N.W., Washington, DC 20006, USA, Abstracts booklet: ISSN: 0733-6373; Price: $10.00 Abstract No. 248 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transfer of maternal varicella-zoster virus antibody to the infant and its persistence during the first two years of life AN - 40576618; 0550194 AU - Asano, Y AU - Tsuruta, M AU - Albrecht, P AU - Vujcic, L K AU - Quinnan, G V AU - Pass, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40576618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transfer+of+maternal+varicella-zoster+virus+antibody+to+the+infant+and+its+persistence+during+the+first+two+years+of+life&rft.au=Asano%2C+Y%3BTsuruta%2C+M%3BAlbrecht%2C+P%3BVujcic%2C+L+K%3BQuinnan%2C+G+V%3BPass%2C+B&rft.aulast=Asano&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: ASM, Publications Sales Dep., 1913 I Street, N.W., Washington, DC 20006, USA, Abstracts booklet: ISSN: 0733-6373; Price: $10.00 Abstract No. 731 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strain differences in induction of antinuclear antibodies by mercuric chloride, gold sodium thiomalate, and D-penicillamine in inbred mice AN - 40573129; 0479598 AU - Robinson, CJG AU - Egorov, I AU - Balazs, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40573129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Strain+differences+in+induction+of+antinuclear+antibodies+by+mercuric+chloride%2C+gold+sodium+thiomalate%2C+and+D-penicillamine+in+inbred+mice&rft.au=Robinson%2C+CJG%3BEgorov%2C+I%3BBalazs%2C+T&rft.aulast=Robinson&rft.aufirst=CJG&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Langerhans-like cells isolated from mouse epidermis AN - 40562243; 0474290 AU - Hellman, K B AU - Schuller, G B AU - Roe, J L AU - Fowler, A K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+Langerhans-like+cells+isolated+from+mouse+epidermis&rft.au=Hellman%2C+K+B%3BSchuller%2C+G+B%3BRoe%2C+J+L%3BFowler%2C+A+K&rft.aulast=Hellman&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of chronic doxorubicin cardiotoxicity in SHR and normotensive rats AN - 40561891; 0461301 AU - Herman, E AU - El-Hage, A AU - Ferrans, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40561891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparison+of+chronic+doxorubicin+cardiotoxicity+in+SHR+and+normotensive+rats&rft.au=Herman%2C+E%3BEl-Hage%2C+A%3BFerrans%2C+V&rft.aulast=Herman&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cadmium inhibition of calcium fluxes in duodenum of the rat AN - 40556859; 0480404 AU - Toraason, M AU - Foulkes, E C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cadmium+inhibition+of+calcium+fluxes+in+duodenum+of+the+rat&rft.au=Toraason%2C+M%3BFoulkes%2C+E+C&rft.aulast=Toraason&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunotoxicological study of isobutyl nitrite AN - 40554783; 0474180 AU - Lewis, D M AU - Koller, WA AU - Lynch, D W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunotoxicological+study+of+isobutyl+nitrite&rft.au=Lewis%2C+D+M%3BKoller%2C+WA%3BLynch%2C+D+W&rft.aulast=Lewis&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Incorporation of ( super(3)H)palmitate into disaturated phosphatidylcholines in rat alveolar macrophages AN - 40554463; 0480563 AU - Miles, PR AU - Bowman, L AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Incorporation+of+%28+super%283%29H%29palmitate+into+disaturated+phosphatidylcholines+in+rat+alveolar+macrophages&rft.au=Miles%2C+PR%3BBowman%2C+L%3BCastranova%2C+V&rft.aulast=Miles&rft.aufirst=PR&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of vitamin and mineral supplement usage by means of a telephone survey AN - 40550938; 0464558 AU - McDonald, J T AU - Stewart, M L AU - Schucker, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Assessment+of+vitamin+and+mineral+supplement+usage+by+means+of+a+telephone+survey&rft.au=McDonald%2C+J+T%3BStewart%2C+M+L%3BSchucker%2C+R+E&rft.aulast=McDonald&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiotoxic effects of a combination of caffeine and isoproterenol AN - 40543700; 0466920 AU - Vick, J AU - Joseph, X AU - Whitehurst, V AU - Balazs, T AU - Herman, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cardiotoxic+effects+of+a+combination+of+caffeine+and+isoproterenol&rft.au=Vick%2C+J%3BJoseph%2C+X%3BWhitehurst%2C+V%3BBalazs%2C+T%3BHerman%2C+E&rft.aulast=Vick&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Qualitative screening of airborne contaminants at hazardous waste sites AN - 40526640; 0390560 AU - Geraci, CL AU - Costello, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Qualitative+screening+of+airborne+contaminants+at+hazardous+waste+sites&rft.au=Geraci%2C+CL%3BCostello%2C+R+J&rft.aulast=Geraci&rft.aufirst=CL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Chemical Society, A.T. Winstead, 1155 16th St. NW, Washington, DC 20036, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Issues concerning the use of potassium iodide as a thyroid-blocking agent in a radiation accident AN - 40526077; 0388792 AU - Shleien, B AU - Halperin, JA AU - Bilstad, J M AU - Kahana, S AU - Dutra, EV Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Issues+concerning+the+use+of+potassium+iodide+as+a+thyroid-blocking+agent+in+a+radiation+accident&rft.au=Shleien%2C+B%3BHalperin%2C+JA%3BBilstad%2C+J+M%3BKahana%2C+S%3BDutra%2C+EV+Jr&rft.aulast=Shleien&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Health Physics, Jul. 1982, Pergamon Press, Fairview Park, Elmsford, NY 10523, USA, Abstract No. P/305 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production of monoclonal antibodies to staphylococcal enterotoxins A and D AN - 40521768; 0394368 AU - Meyer, R F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Production+of+monoclonal+antibodies+to+staphylococcal+enterotoxins+A+and+D&rft.au=Meyer%2C+R+F&rft.aulast=Meyer&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Limulus amoebocyte lysate test as an indicator of coliform density in foods AN - 40518317; 0397804 AU - Smith, A M AU - Hebert, W O AU - Zapatka, F A AU - Hamdy, M K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Skousen%2C+Jeff%3BPerry%2C+Eric%3BLeavitt%2C+Bruce%3BSames%2C+Gary%3BChisholm%2C+William%3BCecil%2C+C+Blaine%3BHammack%2C+Richard&rft.aulast=Skousen&rft.aufirst=Jeff&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Static+tests+for+coal+mining+acid+mine+drainage+prediction+in+the+Eastern+U.S.&rft.title=Static+tests+for+coal+mining+acid+mine+drainage+prediction+in+the+Eastern+U.S.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of benzyl alcohol and bacterial endotoxins: Enhanced toxicity due to combined intravenous administration AN - 40516545; 0401449 AU - Cebula, T A AU - El-Hage, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40516545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interaction+of+benzyl+alcohol+and+bacterial+endotoxins%3A+Enhanced+toxicity+due+to+combined+intravenous+administration&rft.au=Cebula%2C+T+A%3BEl-Hage%2C+A&rft.aulast=Cebula&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulation of in vivo poliovirus RNA synthesis by inhibitors of protein synthesis AN - 40514526; 0387411 AU - Lundquist, R E AU - Dunlap, R C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40514526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulation+of+in+vivo+poliovirus+RNA+synthesis+by+inhibitors+of+protein+synthesis&rft.au=Lundquist%2C+R+E%3BDunlap%2C+R+C&rft.aulast=Lundquist&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a computer-controlled microscope photometer to quantitatively analyze intensity images of immunofluorescent cells AN - 40514028; 0388955 AU - Kaplan, D S AU - Picciolo, G L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40514028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+a+computer-controlled+microscope+photometer+to+quantitatively+analyze+intensity+images+of+immunofluorescent+cells&rft.au=Kaplan%2C+D+S%3BPicciolo%2C+G+L&rft.aulast=Kaplan&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism of 1-methylnaphthalene and 2-methylnaphthalene by the filamentous fungus Cunninghamella elegans AN - 40513504; 0401773 AU - Cerniglia, CE AU - Lambert, K J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40513504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metabolism+of+1-methylnaphthalene+and+2-methylnaphthalene+by+the+filamentous+fungus+Cunninghamella+elegans&rft.au=Cerniglia%2C+CE%3BLambert%2C+K+J&rft.aulast=Cerniglia&rft.aufirst=CE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Yield of High Molecular Weight Retrovirus RNA AN - 40466801; 0285516 AU - Park, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40466801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Improved+Yield+of+High+Molecular+Weight+Retrovirus+RNA&rft.au=Park%2C+J+J&rft.aulast=Park&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: "Developments in Industrial Microbiology", May 1983, Society for Industrial Microbiology, 1401 Wilson Blvd., Arlington, VA 22209, L.C. No. 60-13953; ISSN 0070-4563; Price $34.95 + postage N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity of Protection Against Influenza Virus Infection by Cytotoxic T Lymphocytes in Mice AN - 40460392; 0268929 AU - Wells, MA AU - Daniel, S AU - Kiley, S C AU - Ennis, F A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40460392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Specificity+of+Protection+Against+Influenza+Virus+Infection+by+Cytotoxic+T+Lymphocytes+in+Mice&rft.au=Wells%2C+MA%3BDaniel%2C+S%3BKiley%2C+S+C%3BEnnis%2C+F+A&rft.aulast=Wells&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Program and abstracts book available: American Society for Microbiology, 1913 I St. NW, Washington, DC 20006, ISBN 0-914826-44-1; 182 pages; Price: $10 Poster PV:7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of 111 In-Labeled Leukocytes for Imaging of Experimental Myocarditis AN - 40458575; 0246007 AU - Mantil, J C AU - Fernandez, M AU - Lukes, S AU - van der Bel-Kahn, J AU - Mayfield, G AU - Gerson, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40458575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+111+In-Labeled+Leukocytes+for+Imaging+of+Experimental+Myocarditis&rft.au=Mantil%2C+J+C%3BFernandez%2C+M%3BLukes%2C+S%3Bvan+der+Bel-Kahn%2C+J%3BMayfield%2C+G%3BGerson%2C+M&rft.aulast=Mantil&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "The Journal of Nuclear Medicine", May 1982, Society of Nuclear Medicine, 475 Park Avenue South, New York, NY 10016, Abstracts also available in booklet form N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Virulence and Immunogenicity of Towne Strain and a Low-Passage (Toledo-1 Strain) Isolate of Human Cytomegalovirus AN - 40458170; 0274240 AU - Frederick, W AU - Rook, A AU - Delery, M AU - Epstein, J AU - Ramsey, K AU - Manischewitz, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40458170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparison+of+Virulence+and+Immunogenicity+of+Towne+Strain+and+a+Low-Passage+%28Toledo-1+Strain%29+Isolate+of+Human+Cytomegalovirus&rft.au=Frederick%2C+W%3BRook%2C+A%3BDelery%2C+M%3BEpstein%2C+J%3BRamsey%2C+K%3BManischewitz%2C+J&rft.aulast=Frederick&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Program and Abstracts of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy", 1982, American Society for Microbiology, 1913 I St., NW, Washington, DC 20006 USA, Abstracts and program booklet $10.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folic acid in enriched cereal-grain products by immunoassay AN - 39309480; 3547013 AU - Rader, JI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39309480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Folic+acid+in+enriched+cereal-grain+products+by+immunoassay&rft.au=Rader%2C+JI&rft.aulast=Rader&rft.aufirst=JI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Amercian Association of Cereal Chemists, 3340 Pilot Knob Road, St. Paul, MN 55121-2097, USA; fax: 651 454 07661; email: aacc@scisoc.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of tumor necrosis factor (TNF) in airway reactivity to toluene diisocyanate (TDI) AN - 39268114; 3524646 AU - Matheson, J M AU - Lange, R W AU - Lemus, R AU - Karol, M H AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39268114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+tumor+necrosis+factor+%28TNF%29+in+airway+reactivity+to+toluene+diisocyanate+%28TDI%29&rft.au=Matheson%2C+J+M%3BLange%2C+R+W%3BLemus%2C+R%3BKarol%2C+M+H%3BLuster%2C+MI&rft.aulast=Matheson&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Rapid determination of total trans fat content by attenuated total reflection infrared spectroscopy: An international collaborative study AN - 39261226; 3523909 AU - Mossoba, M M AU - Adam, M AU - Lee, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39261226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rapid+determination+of+total+trans+fat+content+by+attenuated+total+reflection+infrared+spectroscopy%3A+An+international+collaborative+study&rft.au=Mossoba%2C+M+M%3BAdam%2C+M%3BLee%2C+T&rft.aulast=Mossoba&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Oil Chemists' Society, AOCS Meetings and Exhibits Department, P.O. Box 3489, Champaign, Il 61826-3489, USA; phone: 1-217-359-2344; fax: 1-217-351-8091; email: meetings@aocs.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Effect of D-amphetamine on extracellular glutamate and aspartate levels in rat amygdaloid microdialysate AN - 39217038; 3524800 AU - Tor-Agbidye, J AU - Yamamoto, B K AU - Bowyer, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39217038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+D-amphetamine+on+extracellular+glutamate+and+aspartate+levels+in+rat+amygdaloid+microdialysate&rft.au=Tor-Agbidye%2C+J%3BYamamoto%2C+B+K%3BBowyer%2C+J+F&rft.aulast=Tor-Agbidye&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Trimethyltin and LPS induce distinct patterns of cytokine and chemokine expression in rat hippocampus: Lack of an association with injury-induced gliosis AN - 39217017; 3524795 AU - Little, A R AU - O'Callaghan, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39217017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Trimethyltin+and+LPS+induce+distinct+patterns+of+cytokine+and+chemokine+expression+in+rat+hippocampus%3A+Lack+of+an+association+with+injury-induced+gliosis&rft.au=Little%2C+A+R%3BO%27Callaghan%2C+J+P&rft.aulast=Little&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Operation and maintenance of rural drinking water supply systems in Honduras: Factors influencing long-term performance AN - 39210548; 3521473 AU - Gelting, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Operation+and+maintenance+of+rural+drinking+water+supply+systems+in+Honduras%3A+Factors+influencing+long-term+performance&rft.au=Gelting%2C+R&rft.aulast=Gelting&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: NSF International, Center for Public Information at, NSF International, Ann Arbor, MI 48105, USA; phone: 734 827 6888; fax: 734 827 6840; email: raeder@nsf.org; URL: www.nsf.org. Paper No. 5C-5 N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Versatile, portable and low cost computerized data logging and charting system compatible with electronic charts AN - 39210324; 3498287 AU - Pirillo, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Versatile%2C+portable+and+low+cost+computerized+data+logging+and+charting+system+compatible+with+electronic+charts&rft.au=Pirillo%2C+P&rft.aulast=Pirillo&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Marine Technology Society (MTS), 1828 L Street NW, Suite 906, Washington, D.C. 20036, USA; phone: 202-775-5966; email: 75112.2154@compuserve.com; URL: http://www.selectsite.com/oceans95/mts/, Full papers available. Contact MTS for price. Poster Paper N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Latex allergy in the workplace AN - 39204210; 3525169 AU - Toraason, M AU - Germolec, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39204210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Latex+allergy+in+the+workplace&rft.au=Toraason%2C+M%3BGermolec%2C+D&rft.aulast=Toraason&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Antibodies targeting fusion-active structures in HIV-1 gp411 AN - 39200980; 3500851 AU - De Rosny, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39200980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Antibodies+targeting+fusion-active+structures+in+HIV-1+gp411&rft.au=De+Rosny%2C+E&rft.aulast=De+Rosny&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute for Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA; phone: 410-706-8614; email: valuckas@umbi.umd.edu; URL: www.ihv.org, Abstracts available. Contact IHV for price. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Risk assessment-based approach for the biological evaluation of medical device materials AN - 39198924; 3524604 AU - Stratmeyer, ME AU - Brown, R P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39198924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Risk+assessment-based+approach+for+the+biological+evaluation+of+medical+device+materials&rft.au=Stratmeyer%2C+ME%3BBrown%2C+R+P&rft.aulast=Stratmeyer&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Animal models and mechanisms of latex allergy AN - 39194325; 3525173 AU - Meade, B J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39194325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Animal+models+and+mechanisms+of+latex+allergy&rft.au=Meade%2C+B+J&rft.aulast=Meade&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Vitamin E deficiency increases susceptibility of the Balb/C mouse to MDMA-induced dopaminergic neurotoxicity AN - 39193615; 3524798 AU - Johnson, E A AU - Shvedova, A A AU - Kisin, E AU - O'Callaghan, J P AU - Kommineni, C AU - Miller, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39193615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Vitamin+E+deficiency+increases+susceptibility+of+the+Balb%2FC+mouse+to+MDMA-induced+dopaminergic+neurotoxicity&rft.au=Johnson%2C+E+A%3BShvedova%2C+A+A%3BKisin%2C+E%3BO%27Callaghan%2C+J+P%3BKommineni%2C+C%3BMiller%2C+D+B&rft.aulast=Johnson&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Activation of activator protein-1 by reactive oxygen species associated with asbestos AN - 39187996; 3525759 AU - Vallyathan, V AU - Ding, M AU - Shi, X AU - Castranova, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39187996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activation+of+activator+protein-1+by+reactive+oxygen+species+associated+with+asbestos&rft.au=Vallyathan%2C+V%3BDing%2C+M%3BShi%2C+X%3BCastranova%2C+V&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Phosphodiesterase type III (PDE III) inhibitor induces vasculitis preceded by apoptosis in mesenteric vessels and lymphoid tissues in rats AN - 39187265; 3525623 AU - Zhang, J AU - Herman, E H AU - Weaver, J L AU - Chadwick, D P AU - Broud, D AU - Rosenzweig, BA AU - Knapton, AD AU - Whitehurst, V E AU - Sistare, F D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39187265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Phosphodiesterase+type+III+%28PDE+III%29+inhibitor+induces+vasculitis+preceded+by+apoptosis+in+mesenteric+vessels+and+lymphoid+tissues+in+rats&rft.au=Zhang%2C+J%3BHerman%2C+E+H%3BWeaver%2C+J+L%3BChadwick%2C+D+P%3BBroud%2C+D%3BRosenzweig%2C+BA%3BKnapton%2C+AD%3BWhitehurst%2C+V+E%3BSistare%2C+F+D&rft.aulast=Zhang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Redox-cycling of phenols causes depletion of GSH, oxidative stress and cytotoxicity in normal human epidermal keratinocytes (NHEKS) AN - 39186325; 3525385 AU - Kisin, E R AU - Kommineni, C AU - Tyurina, Y Y AU - Tyurin, V A AU - Schwegler-Berry, D AU - Castranova, V AU - Kagan, V E AU - Shvedova, A A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39186325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Redox-cycling+of+phenols+causes+depletion+of+GSH%2C+oxidative+stress+and+cytotoxicity+in+normal+human+epidermal+keratinocytes+%28NHEKS%29&rft.au=Kisin%2C+E+R%3BKommineni%2C+C%3BTyurina%2C+Y+Y%3BTyurin%2C+V+A%3BSchwegler-Berry%2C+D%3BCastranova%2C+V%3BKagan%2C+V+E%3BShvedova%2C+A+A&rft.aulast=Kisin&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Safety risk assessment of the mycotoxin patulin in apple juice and apple juice products AN - 39186059; 3525280 AU - Henry, SH AU - DiNovi, MJ AU - Bolger, P M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39186059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Safety+risk+assessment+of+the+mycotoxin+patulin+in+apple+juice+and+apple+juice+products&rft.au=Henry%2C+SH%3BDiNovi%2C+MJ%3BBolger%2C+P+M&rft.aulast=Henry&rft.aufirst=SH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Hydrogen peroxide inhibits activation, not activity, of cellular caspase-3 AN - 39185845; 3517311 AU - Shacter, E AU - Lee, Y-J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39185845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hydrogen+peroxide+inhibits+activation%2C+not+activity%2C+of+cellular+caspase-3&rft.au=Shacter%2C+E%3BLee%2C+Y-J&rft.aulast=Shacter&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science, Inc., 655 Avenue of the Americas, New York, NY 10010-5107; phone: 212-633-3730; fax: 212-633-3680; email: usinfo-f@elsevier.com; URL: www.elsevier.com, Full Abstracts Available. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Assessment of DNA damage in workers exposed to roofing asphalt AN - 39184850; 3525073 AU - Reid, T AU - Hayden, C AU - Marlow, D AU - Rinehart, R AU - Mierz, J AU - Werren, D AU - Toraason, M AU - DeBord, D G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39184850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Assessment+of+DNA+damage+in+workers+exposed+to+roofing+asphalt&rft.au=Reid%2C+T%3BHayden%2C+C%3BMarlow%2C+D%3BRinehart%2C+R%3BMierz%2C+J%3BWerren%2C+D%3BToraason%2C+M%3BDeBord%2C+D+G&rft.aulast=Reid&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) in the rat after low-dose, chronic administration AN - 39183828; 3524522 AU - Patterson, T A AU - Slikker, W Jr AU - Binienda, Z AU - Duhart, H AU - Lipe, G AU - Newport, G AU - Sandberg, JA AU - Kim, C S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39183828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+of+2%2C4-dichlorophenoxyacetic+acid+%282%2C4-D%29+in+the+rat+after+low-dose%2C+chronic+administration&rft.au=Patterson%2C+T+A%3BSlikker%2C+W+Jr%3BBinienda%2C+Z%3BDuhart%2C+H%3BLipe%2C+G%3BNewport%2C+G%3BSandberg%2C+JA%3BKim%2C+C+S&rft.aulast=Patterson&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Evaluation of a FitCheck hearing protector test system AN - 39181022; 3511290 AU - Murphy, W J AU - Franks, J R AU - Harris, DA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39181022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+a+FitCheck+hearing+protector+test+system&rft.au=Murphy%2C+W+J%3BFranks%2C+J+R%3BHarris%2C+DA&rft.aulast=Murphy&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Acoustical Society of America, Suite 1, Number 1, 2 Huntington Quadrangle, Melville, NY 11747-4502, USA; phone: 516-576-2360; email: asa@aip.org; URL: asa.aip.org, Abstracts available. Price $100. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - USFDA/NIEHS phototoxicology research center: Understanding and developing animal models for photocarcinogenesis testing AN - 39179008; 3525631 AU - Howard, P C AU - Sams, R L AU - Miller, B J AU - Wamer, W G AU - Beer, J Z Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39179008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=USFDA%2FNIEHS+phototoxicology+research+center%3A+Understanding+and+developing+animal+models+for+photocarcinogenesis+testing&rft.au=Howard%2C+P+C%3BSams%2C+R+L%3BMiller%2C+B+J%3BWamer%2C+W+G%3BBeer%2C+J+Z&rft.aulast=Howard&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Animal models and consideration of immune system development AN - 39178106; 3526348 AU - Hastings, K L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39178106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Animal+models+and+consideration+of+immune+system+development&rft.au=Hastings%2C+K+L&rft.aulast=Hastings&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - LC/MS confirmation of animal drug residues for regulatory use AN - 39168851; 3491514 AU - Turnipseed, S B AU - Gonzales, SA AU - Pfenning, A P AU - Roybal, J B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39168851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=LC%2FMS+confirmation+of+animal+drug+residues+for+regulatory+use&rft.au=Turnipseed%2C+S+B%3BGonzales%2C+SA%3BPfenning%2C+A+P%3BRoybal%2C+J+B&rft.aulast=Turnipseed&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Milestone Presentations, 4255 S. Buckley Road, Suite 118, Aurora, CO 80013, USA; phone: 800-996-3233; fax: 303-690-3233; email: milestone@bod.net; URL: www.milestoneshows.com, Abstracts available. Price $25. Paper No. 210 N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Exposure to silica activates macrophages and increases the pulmonary clearance of listeria monocytogenes in rats AN - 39166444; 3525966 AU - Yang, H AU - Ma, JYC AU - Roberts, J R AU - Barger, M W AU - Butterworth, L AU - Castranova, V AU - Antonini, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39166444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Exposure+to+silica+activates+macrophages+and+increases+the+pulmonary+clearance+of+listeria+monocytogenes+in+rats&rft.au=Yang%2C+H%3BMa%2C+JYC%3BRoberts%2C+J+R%3BBarger%2C+M+W%3BButterworth%2C+L%3BCastranova%2C+V%3BAntonini%2C+J+M&rft.aulast=Yang&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - U.S. regulatory perspective for prion issues AN - 39158605; 3499975 AU - Asher, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39158605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=U.S.+regulatory+perspective+for+prion+issues&rft.au=Asher%2C+D+M&rft.aulast=Asher&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IBC USA, 225 Turnpike Road, Southborough, MA 01772-1749, USA; phone: 508-481-6400; email: inq@ibcusa.com; URL: www.ibcusa.com/2407, Abstracts available. Price $195 (plus S&H). N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Human health and ecologic impacts of DDT AN - 39152090; 3517726 AU - DeRosa, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39152090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+health+and+ecologic+impacts+of+DDT&rft.au=DeRosa%2C+C&rft.aulast=DeRosa&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for the Advancement of Science, 1333 H St., NW, 8th Floor, Washington, DC 20005, USA; URL: www.aaas.org, Titles are taken from selected sections of the larger conference. N1 - Last updated - 2011-10-26 ER - TY - JOUR T1 - Risk assessment used to evaluate the US position on Listeria monocytogenes in seafood. AN - 72532185; 11156269 AB - Human listeriosis has been associated with consumption of food including seafood. Surveillance information on the presence of Listeria monocytogenes in seafood products is presented as a background for steps that are being taken to inform risk managers of risks associated with particular food products. United States policy for L. monocytogenes in food has been shaped by our increasing knowledge of the epidemiology of outbreaks and sporadic cases of human listeriosis, the potentially severe public health consequences, and the characteristics of the organism. A quantitative risk assessment of the scientific knowledge we have about the organism and the epidemiology of listeriosis should be the basis for changes in this policy. Risk assessment uses quantitative scientific and epidemiological information in a structured format to determine the risks associated with particular hazards. A quantitative risk assessment is being performed using currently available data by the US Food and Drug Administration, in collaboration with the US Food Safety and Inspection Service, to determine the risk of listeriosis from various foods, including seafood, for specific intervention methods, and for general and at-risk population groups. The questions being considered include those on level of consumption, epidemiology, dose response, and the virulence, biology, and ecology of the organism. Risk managers can use the resulting information to form a defendable science-based policy on L. monocytogenes in food. JF - International journal of food microbiology AU - Elliot, E L AU - Kvenberg, J E AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA. eelliot@cfsan.fda.gov Y1 - 2000/12/20/ PY - 2000 DA - 2000 Dec 20 SP - 253 EP - 260 VL - 62 IS - 3 SN - 0168-1605, 0168-1605 KW - Index Medicus KW - Animals KW - Humans KW - Public Policy KW - United States -- epidemiology KW - Risk Assessment KW - Listeriosis -- epidemiology KW - Listeria monocytogenes -- isolation & purification KW - Listeria monocytogenes -- growth & development KW - Food Microbiology -- legislation & jurisprudence KW - Disease Outbreaks -- prevention & control KW - Listeriosis -- prevention & control KW - Seafood -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72532185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Risk+assessment+used+to+evaluate+the+US+position+on+Listeria+monocytogenes+in+seafood.&rft.au=Elliot%2C+E+L%3BKvenberg%2C+J+E&rft.aulast=Elliot&rft.aufirst=E&rft.date=2000-12-20&rft.volume=62&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-17 N1 - Date created - 2001-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of mucAB-like homologs on two IncT plasmids, R394 and Rts-1. AN - 72461933; 11106794 AB - Recent phylogenetic analysis of the superfamily of lesion-replicating DNA polymerases suggest that they can be broadly divided into four sub-groups comprised of UmuC-like, DinB-like, Rev1-like and Rad30-like proteins. The UmuC-like sub-family is best characterized at the genetic level and sequence analysis of eleven umu orthologs, residing on bacterial chromosomes or on self-transmissible R-plasmids allows further subdivision into five sub-groups (UmuDC, MucAB, ImpAB, RumAB and RulAB) based on amino acid sequence conservation. Some of these orthologs are apparently inactive in situ, but may promote increased mutagenesis and survival when subcloned and expressed from high-copy number plasmids. We were, therefore, interested in devising an assay that would identify umuC-like genes in situ in the absence of a functional assay. To this end, degenerate primers directed towards conserved amino acid regions within the UmuC-like sub-family of DNA polymerases were designed and used to identify mucAB-like operons on the IncT plasmids, R394 and Rts-1.Interestingly, DNA sequence analysis of an approximately 7kb region of R394 identified two LexA-regulated genes immediately downstream of mucAB((R394)) that are similar to the chromosomally-encoded Escherichia coli tus gene and the IncI plasmid-encoded impC gene, respectively. Analysis of the R394 and Rts-1 mucB genes revealed that both contain insertions which result in the expression of a truncated inactive MucB protein. While R394 was unable to restore mutagenesis functions to a DeltaumuDC E. coli strain, Rts-1 surprisingly promoted significant levels of MMS-induced SOS mutagenesis, raising the possibility that Rts-1 encodes another, yet unidentified, umu-like homolog. JF - Mutation research AU - Koch, W H AU - Fernández de Henestrosa, A R AU - Woodgate, R AD - Molecular Biology Branch, Food and Drug Administration, 20204, Washington, DC, USA. Y1 - 2000/12/20/ PY - 2000 DA - 2000 Dec 20 SP - 1 EP - 13 VL - 457 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Bacterial Proteins KW - 0 KW - DNA Primers KW - DNA, Bacterial KW - Escherichia coli Proteins KW - ImpC protein, Bacteria KW - LexA protein, Bacteria KW - mucAB protein, E coli KW - 138186-81-9 KW - UmuC protein, E coli KW - 98059-80-4 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - Index Medicus KW - SOS Response (Genetics) KW - DNA Primers -- genetics KW - Operon KW - Amino Acid Sequence KW - Cloning, Molecular KW - Gene Amplification KW - Mutagenesis KW - Base Sequence KW - Methyl Methanesulfonate -- toxicity KW - Serine Endopeptidases -- genetics KW - DNA, Bacterial -- genetics KW - R Factors -- genetics KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Genes, Bacterial KW - Bacterial Proteins -- genetics KW - Plasmids -- genetics KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Identification+of+mucAB-like+homologs+on+two+IncT+plasmids%2C+R394+and+Rts-1.&rft.au=Koch%2C+W+H%3BFern%C3%A1ndez+de+Henestrosa%2C+A+R%3BWoodgate%2C+R&rft.aulast=Koch&rft.aufirst=W&rft.date=2000-12-20&rft.volume=457&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Collaborative Education To Ensure Patient Safety. AN - 62190919; ED468611 AB - Results of a joint meeting between national advisory councils in medicine and nursing on physician-nurse collaboration to enhance patient safety are reported. Recommendations on which participants reached consensus are organized by these Institute of Medicine (IOM) themes: establish a national focus to create leadership through research and protocols to enhance the knowledge base about safety; identify and learn from errors through immediate, strong mandatory reporting efforts; raise standards and expectations for improvements in safety; and create safety systems inside health care organizations through implementation of safe practices at the delivery level. A summary of collaborative activities follows. The issues as outlined by speakers at the meeting are organized by IOM themes. Seven manuscripts are "Putting Patients First: Improving Patient Safety Through Collaborative Education" (Wakefield); "Managing Error for System Improvement" (Kaplan, Battles); "Preventing Patient Injuries" (James); "Collaborative Education to Improve Public Safety" (Conway-Welch); "Learning to Improve Complex Systems of Care" (Headrick); "Using Clinical Computing to Enhance Physician and Nurse Collaboration and to Improve Patient Safety" (Gardner); and "Collaborative Education to Improve Public Safety" (Swankin). Three annotated bibliographies are appended: nurse-physician collaboration in practice (71 items); interdisciplinary (interprofessional) education (88); and medical errors and error prevention (79). (YLB) Y1 - 2000/12/20/ PY - 2000 DA - 2000 Dec 20 SP - 151 PB - Health Resources and Services Administration Information Center, P.O. Box 2910, Merrifield, VA 22116. Tel: 1-888-Ask-HRSA; Fax: 703-821-2098; e-mail: ask@hrsa.gov; Web site: http://www.ask.hrsa.gov. For full text: http://www.bhpr.hrsa.gov/dn/nacnep. KW - Institute of Medicine DC KW - Nurse Physician Relationship KW - Patient Care KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Interprofessional Relationship KW - Coordination KW - Cooperative Programs KW - Safety KW - Nurses KW - Patients KW - Health Education KW - Professional Continuing Education KW - Error Correction KW - Medical Education KW - Health Promotion KW - Advisory Committees KW - Educational Cooperation KW - Partnerships in Education KW - Physicians KW - Error Patterns KW - Interdisciplinary Approach KW - Malpractice KW - Annotated Bibliographies KW - Medical Services KW - Education Work Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62190919?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Report to the Secretary of the U.S. Department of N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Quantification of Etheno-DNA Adducts Using Liquid Chromatography, On-Line Sample Processing, and Electrospray Tandem Mass Spectrometry AN - 17764635; 4821002 AB - Etheno-DNA adducts are promutagenic lesions present in normal animal and human tissues that are believed to be important in the etiology of cancer related to diet and lifestyle. A method has been developed for the quantification of trace levels of etheno-DNA adducts using on-line sample preparation coupled with liquid chromatography and electrospray tandem mass spectrometry. The use of automated solid-phase extraction and stable labeled internal standards permitted the robust determination of ethenodeoxyadenosine contained in crude DNA hydrolysates from untreated rodent and human tissues at levels on the order of one adduct in 10 super(8) normal nucleotides from 100 mu g of DNA. Inherent analyte response and matrix interference made sensitivity for simultaneous determination of ethenodeoxycytidine approximately 5-fold lower. The method was applied to the analysis of liver DNA from untreated and urethane-treated B6C3F1 mice, untreated rat liver, human placenta, and several commercial DNA preparations. Some sources of potential artifactual formation of etheno-DNA adducts were investigated. JF - Chemical Research in Toxicology AU - Doerge AU - Churchwell, MI AU - Fang, Jia-Long AU - Beland, F A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2000/12/18/ PY - 2000 DA - 2000 Dec 18 SP - 1259 EP - 1264 VL - 13 IS - 12 SN - 0893-228X, 0893-228X KW - measuring techniques KW - electrospray tandem mass spectrometry KW - on-line sample processing KW - Toxicology Abstracts KW - DNA adducts KW - Liquid chromatography KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17764635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Quantification+of+Etheno-DNA+Adducts+Using+Liquid+Chromatography%2C+On-Line+Sample+Processing%2C+and+Electrospray+Tandem+Mass+Spectrometry&rft.au=Doerge%3BChurchwell%2C+MI%3BFang%2C+Jia-Long%3BBeland%2C+F+A&rft.aulast=Doerge&rft.aufirst=&rft.date=2000-12-18&rft.volume=13&rft.issue=12&rft.spage=1259&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA adducts; Liquid chromatography ER - TY - JOUR T1 - Lung responses to hypothyroidism, hyperthyroidism, and lipopolysaccharide challenge in rats. AN - 72515365; 11127416 AB - The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on some factors involved in lung injury under basal conditions (air exposure) and during an inflammatory response induced by inhalation exposure to lipopolysaccharide (LPS; 100 microg/ml; 3 h) in adult rats. Thyroid status was altered by thyroidectomy or thyroxine injections for 15 d. Hyperthyroidism alone caused a greater degree of lung cell damage, an increase in the permeability of the alveolar-capillary barrier, a rise in the total number of phagocytic cells obtained by bronchoalveolar lavage (BAL), and enhanced nitric oxide (NO) release by phagocytic cells relative to that in euthyroid control animals. Hypothyroidism alone was associated with opposite effects. Exposure of animals to LPS produced inflammatory responses, which included significant increases in lung cell damage, permeability of the alveolar-capillary barrier, number of phagocytic cells obtained by BAL, and NO production by the phagocytic cells. In general, hyperthyroidism enhanced the effects of LPS, while hypothyroidism reduced LPS-induced responses. These results suggest that thyroid status alone can affect some of the factors involved in lung injury and also modulate some of the inflammatory effects of LPS. Hyperthyroidism tends to enhance lung injury, while hypothyroidism seems to reduce lung injury. JF - Journal of toxicology and environmental health. Part A AU - Huffman, L J AU - Judy, D J AU - Rao, K M AU - Frazer, D G AU - Goldsmith, W T AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. ljh3@cdc.gov Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 623 EP - 639 VL - 61 IS - 7 SN - 1528-7394, 1528-7394 KW - Albumins KW - 0 KW - Endotoxins KW - Lipopolysaccharides KW - Nitric Oxide KW - 31C4KY9ESH KW - endotoxin, Escherichia coli KW - 67924-63-4 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Albumins -- metabolism KW - Animals KW - Cell Count KW - Nitric Oxide -- metabolism KW - Endotoxins -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Capillaries -- pathology KW - Cell Membrane Permeability -- drug effects KW - Thyroxine -- toxicity KW - Body Weight -- drug effects KW - Phagocytes -- drug effects KW - Bronchoalveolar Lavage Fluid -- cytology KW - L-Lactate Dehydrogenase -- metabolism KW - Male KW - Hyperthyroidism -- pathology KW - Hypothyroidism -- pathology KW - Lipopolysaccharides -- toxicity KW - Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72515365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Lung+responses+to+hypothyroidism%2C+hyperthyroidism%2C+and+lipopolysaccharide+challenge+in+rats.&rft.au=Huffman%2C+L+J%3BJudy%2C+D+J%3BRao%2C+K+M%3BFrazer%2C+D+G%3BGoldsmith%2C+W+T&rft.aulast=Huffman&rft.aufirst=L&rft.date=2000-12-15&rft.volume=61&rft.issue=7&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dermal and systemic toxicity after application of semisynthetic metal-working fluids in B6C3F1 mice. AN - 72510876; 11127413 AB - About 10 million industrial workers of both sexes are exposed to metal-working fluids (MWFs) via inhalation, skin or both. Our preliminary results, following dermal application of 200 microl of 50% unused (neat) semisynthetic MWF (pH 7 or pH 9.7) to the unshaved backs of 6-wk-old B6C3F1 mice, twice a week for 6 wk, produced significant increase in weights of the liver of both sexes. The purpose of the present study was to determine if this weight change was related to oxidative stress subsequent to MWF exposure and also to determine whether ethanol intake influences this effect. Therefore, 6-mo-old mice of both sexes were exposed to MWFs following the protocol just described, except that the topical application was with 5% MWFs (pH 7 and 9.7, 5 d/wk) with or without adding 5% ethanol to their drinking water (7 d/wk) for 13 wk. The skin histamine levels and mast-cell numbers were significantly increased in the female group treated with 55% MWF (pH 7). The ascorbic acid levels in the liver (both sexes) (all groups except 5%, MWF pH 9.7 males) and testes were reduced significantly. Malondialdehyde levels in the male liver were significantly increased with topical MWF exposure. Glutathione levels were reduced significantly in both male and female liver after 5% MWF (pH 7). Alcohol dehydrogenase activity of the male liver increased significantly after MWF (pH 7). These results suggest that MWFs are absorbed through the skin and produce toxicity in the liver of both sexes and in the male gonads. This may represent an important health risk to MWF-exposed industrial workers, and ethanol may exacerbate this risk. JF - Journal of toxicology and environmental health. Part A AU - Al-Humadi, N H AU - Shvedova, A A AU - Batteli, L AU - Diotte, N AU - Castranova, V AU - Kommineni, C AD - Health Effects Laboratory Division, NIOSH, CDC, Morgantown, West Virginia 26505, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 579 EP - 589 VL - 61 IS - 7 SN - 1528-7394, 1528-7394 KW - Indicators and Reagents KW - 0 KW - Malondialdehyde KW - 4Y8F71G49Q KW - Histamine KW - 820484N8I3 KW - Alcohol Dehydrogenase KW - EC 1.1.1.1 KW - Glutathione KW - GAN16C9B8O KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Malondialdehyde -- metabolism KW - Animals KW - Mast Cells -- metabolism KW - Glutathione -- metabolism KW - Mice KW - Histamine -- metabolism KW - Alcohol Dehydrogenase -- metabolism KW - Ascorbic Acid -- metabolism KW - Mast Cells -- drug effects KW - Male KW - Female KW - Industrial Oils -- toxicity KW - Skin Diseases -- metabolism KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72510876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Dermal+and+systemic+toxicity+after+application+of+semisynthetic+metal-working+fluids+in+B6C3F1+mice.&rft.au=Al-Humadi%2C+N+H%3BShvedova%2C+A+A%3BBatteli%2C+L%3BDiotte%2C+N%3BCastranova%2C+V%3BKommineni%2C+C&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0160502608&rft.btitle=Healthy+People+2010%3A+Understanding+and+Improving+Health.&rft.title=Healthy+People+2010%3A+Understanding+and+Improving+Health.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic cells. AN - 72506825; 11127415 AB - In the present study, the effects of ochratoxin A (OTA) on cytotoxicity, cell differentiation, and other cell functions in the embryonic midbrain cells, which are dopaminergic, were compared to those in the limb bud cells, which are nondopaminergic, to assess the selectivity of OTA central action. Twelve-day rat embryo midbrain and limb bud cells were cultured in Dulbecco's modified Eagle's medium nutrient and Ham's F12 (1:1) mix ture containing 10% Nuserum for 96 h in the presence of various concentrations of OTA. OTA signicfiantly reduced the levels of protein, DNA and glutathione, and [H]thymidine incorporation into DNA in both embryonic midbrain and limb bud cells in a similar concentration-dependent manner. The IC50 values for cytotoxicity measured by neutral red uptake were 1.10 microM in the midbrain cells and 1.05 microM in the limb bud cells. The IC50 values of cell differentiation were 1.10 microM in the midbrain cells and 1.0 microM in the limb bud cells. The addition of exogenous glutathione (32.5 microM) did not change the OTA-induced fall in protein and DNA levels, or the IC50 values of cytotoxicity and differentiation in the midbrain and limb bud cells. Data show that OTA does not appear to exert a selective toxic dopaminergic cell action and that OTA-induced cytotoxicity and inhibition of cell differentiation were not prevented by exogenous glutathione. JF - Journal of toxicology and environmental health. Part A AU - Hong, J T AU - Park, K L AU - Han, S Y AU - Park, K S AU - Kim, H S AU - Oh, S D AU - Lee, R D AU - Jang, S J AD - National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul. jinthong@kfda.go.kr Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 609 EP - 621 VL - 61 IS - 7 SN - 1528-7394, 1528-7394 KW - Carcinogens KW - 0 KW - Ochratoxins KW - Proteins KW - ochratoxin A KW - 1779SX6LUY KW - DNA KW - 9007-49-2 KW - Glutathione KW - GAN16C9B8O KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Limb Buds -- drug effects KW - Animals KW - Limb Buds -- cytology KW - DNA -- metabolism KW - Glutathione -- metabolism KW - Cell Division -- drug effects KW - Limb Buds -- embryology KW - Mesencephalon -- cytology KW - Proteins -- metabolism KW - Thymidine -- metabolism KW - Rats KW - Mesencephalon -- drug effects KW - Rats, Sprague-Dawley KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Mesencephalon -- embryology KW - Cell Differentiation -- drug effects KW - Ochratoxins -- toxicity KW - Embryo, Mammalian -- cytology KW - Carcinogens -- toxicity KW - Embryo, Mammalian -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72506825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Effects+of+ochratoxin+A+on+cytotoxicity+and+cell+differentiation+in+cultured+rat+embryonic+cells.&rft.au=Hong%2C+J+T%3BPark%2C+K+L%3BHan%2C+S+Y%3BPark%2C+K+S%3BKim%2C+H+S%3BOh%2C+S+D%3BLee%2C+R+D%3BJang%2C+S+J&rft.aulast=Hong&rft.aufirst=J&rft.date=2000-12-15&rft.volume=61&rft.issue=7&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistein AN - 17750732; 4813890 AB - Fecal bacteria from a healthy individual were screened for the specific bacteria involved in the metabolism of dietary isoflavonoids. Two strains of bacteria capable of producing primary and secondary metabolites from the natural isoflavone glycosides daidzin and genistin were detected. The metabolites were identified by comparison of their HPLC/mass, super(1)H NMR and UV spectra with those of standard and synthetic compounds. Both Escherichia coli HGH21 and the gram-positive strain HGH6 converted daidzin and genistin to the their respective aglycones daidzein and genistein. Under anoxic conditions, strain HGH6 further metabolized the isoflavones daidzein and genistein to dihydrodaidzein and dihydrogenistein, respectively. The reduction of a double bond between C-2 and C-3 to a single bond was isoflavonoid-specific by strain HGH6, which did not reduce a similar bond in the flavonoids apigenin and chrysin. Strain HGH6 did not further metabolize dihydrodaidzein and dihydrogenistein. This is the first study in which specific colonic bacteria that are involved in the metabolism of daidzin and genistin have been detected. JF - Archives of Microbiology AU - Hur, H G AU - Lay, JOJr AU - Beger, R D AU - Freeman, J P AU - Rafii, F AD - Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, 72079-9502, USA, frafii@nctr.fda.gov Y1 - 2000/12/11/ PY - 2000 DA - 2000 Dec 11 SP - 422 EP - 428 PB - Springer-Verlag VL - 174 IS - 6 SN - 0302-8933, 0302-8933 KW - man KW - daidzien KW - isoflavonoids KW - Microbiology Abstracts B: Bacteriology KW - Microflora KW - Intestine KW - Escherichia coli KW - Genistein KW - J 02841:Microflora UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17750732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Microbiology&rft.atitle=Isolation+of+human+intestinal+bacteria+metabolizing+the+natural+isoflavone+glycosides+daidzin+and+genistein&rft.au=Hur%2C+H+G%3BLay%2C+JOJr%3BBeger%2C+R+D%3BFreeman%2C+J+P%3BRafii%2C+F&rft.aulast=Hur&rft.aufirst=H&rft.date=2000-12-11&rft.volume=174&rft.issue=6&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Archives+of+Microbiology&rft.issn=03028933&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Intestine; Microflora; Genistein ER - TY - JOUR T1 - Neuronal degeneration in the limbic system of weanling rats exposed to saline, hyperthermia or d-amphetamine. AN - 72455785; 11102570 AB - Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. Neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreactivity in the caudate-putamen (CPu) and decreases in CPu tissue dopamine levels in weanlings was much less than those previously observed in adults. The neurotoxicity seen in the parietal cortex and CPu of the weanlings was much less than previously seen in adults even though severe hyperthermia and the behavior of retrograde propulsion occurred during AMPH exposure. Neurodegeneration was not detected in any of the previously mentioned brain regions in controls and weanlings made hyperthermic by a warm environment. However, signs of spontaneous neurodegeneration were seen in the posterior piriform cortex (Pir), posteriolateral cortical amygdaloid nucleus (PLCo), and the amygdalopiriform transition area (APir) of control weanlings. The doses of AMPH and the degree of hyperthermia necessary to induce seizures were substantially lower in weanlings compared to those previously observed in adult rats. Further studies will be necessary to determine if the susceptibility of weanlings to AMPH-induced seizures is related to or dependent on the same processes involved in producing degeneration in the posterior limbic system of saline controls. JF - Brain research AU - Bowyer, J F AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2000/12/08/ PY - 2000 DA - 2000 Dec 08 SP - 166 EP - 171 VL - 885 IS - 2 SN - 0006-8993, 0006-8993 KW - Central Nervous System Stimulants KW - 0 KW - Glial Fibrillary Acidic Protein KW - Sodium Chloride KW - 451W47IQ8X KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Animals KW - Caudate Nucleus -- metabolism KW - Prosencephalon -- metabolism KW - Glial Fibrillary Acidic Protein -- metabolism KW - Weaning KW - Caudate Nucleus -- drug effects KW - Motor Activity -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Glial Fibrillary Acidic Protein -- drug effects KW - Prosencephalon -- drug effects KW - Putamen -- physiology KW - Motor Activity -- drug effects KW - Male KW - Putamen -- drug effects KW - Seizures -- chemically induced KW - Fever -- chemically induced KW - Limbic System -- drug effects KW - Limbic System -- metabolism KW - Nerve Degeneration -- metabolism KW - Nerve Degeneration -- chemically induced KW - Central Nervous System Stimulants -- adverse effects KW - Fever -- metabolism KW - Sodium Chloride -- pharmacology KW - Dextroamphetamine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72455785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Virtual+Neuropathology%3A+Three-Dimensional+Visualization+of+Lesions+Due+to+Toxic+Insult&rft.au=Lester%2C+David+S%3BPine%2C+PScott%3BDelnomdedieu%2C+Marielle%3BJohannessen%2C+Jan+N%3BJohnson%2C+GAllan&rft.aulast=Lester&rft.aufirst=David&rft.date=2000-01-01&rft.volume=28&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F019262330002800112 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Prospective Study of Back Belts for Prevention of Back Pain and Injury AN - 18244743; 5304249 AB - Despite scientific uncertainties about effectiveness, wearing back belts in the hopes of preventing costly and disabling low back injury in employees is becoming common in the workplace. To evaluate the effectiveness of using back belts in reducing back injury claims and low back pain. Prospective cohort study. From April 1996 through April 1998, we identified material-handling employees in 160 new retail merchandise stores (89 required back belt use; 71 had voluntary back belt use) in 30 states (from New Hampshire to Michigan in the north and from Florida to Texas in the south); data collection ended December 1998, median follow-up was 6 1/2 months. A referred sample of 13,873 material handling employees provided 9377 baseline interviews and 6311 (67%) follow-up interviews; 206 (1.4%) refused baseline interview. Incidence rate of material-handling back injury workers' compensation claims and 6-month incidence rate of self-reported low back pain. Neither frequent back belt use nor a belt-requirement store policy was significantly associated with back injury claim rates or self-reported back pain. Rate ratios comparing back injury claims of those who reported wearing back belts usually every day and once or twice a week vs those who reported wearing belts never or once or twice a month were 1.22 (95% confidence interval [CI], 0.87-1.70) and 0.95 (95% CI, 0.56-1.59), respectively. The respective odds ratios for low back pain incidence were 0.97 (95% CI, 0.83-1.13) and 0.92 (95% CI, 0.73-1.16). In the largest prospective cohort study of back belt use, adjusted for multiple individual risk factors, neither frequent back belt use nor a store policy that required belt use was associated with reduced incidence of back injury claims or low back pain. JF - Journal of the American Medical Association AU - Wassell, J T AU - Gardner, LI AU - Landsittel, D P AU - Johnston, J J AU - Johnston, J M AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Rd, Morgantown, WV 26505, USA, jtw2@cdc.gov Y1 - 2000/12/06/ PY - 2000 DA - 2000 Dec 06 SP - 2727 EP - 2732 VL - 284 IS - 21 SN - 0098-7484, 0098-7484 KW - back belts KW - back pain KW - working conditions KW - Health & Safety Science Abstracts KW - Injuries KW - Materials handling KW - Occupational safety KW - Protective equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18244743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=A+Prospective+Study+of+Back+Belts+for+Prevention+of+Back+Pain+and+Injury&rft.au=Wassell%2C+J+T%3BGardner%2C+LI%3BLandsittel%2C+D+P%3BJohnston%2C+J+J%3BJohnston%2C+J+M&rft.aulast=Wassell&rft.aufirst=J&rft.date=2000-12-06&rft.volume=284&rft.issue=21&rft.spage=2727&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; Protective equipment; Materials handling; Injuries ER - TY - JOUR T1 - Analytical procedure for quantifying five compounds suspected as possible contaminants in recycled paper/paperboard for food packaging. AN - 72602399; 11141258 AB - Because contaminants in recycled paper intended for food packaging could be a risk to public health, analytical methods are needed to identify and quantify residues of concern in paper/paperboard. The U. S. Food and Drug Administration is considering development of a guidance document for testing levels of contaminants that might be retained through paper recycling processes. An analytical procedure was developed using paper spiked with suspected contaminants at concentrations of 1-50 ppm in the paper. Benzophenone, dimethyl phthalate, anthracene, methyl stearate, and pentachlorophenol were introduced by soaking the paper in a solution in acetone at 25 degrees C for 24 h; the paper was removed and dried by evaporating the solvent with nitrogen. The model contaminant residues were extracted from the paper using ultrasonication and quantified by GC with flame ionization and electron capture detectors. Recoveries from the spiked paper were 80-109% with a repeatability of +/-4%. The method was also used to analyze commercial recycled paperboard to validate its applicability. JF - Journal of agricultural and food chemistry AU - Song, Y S AU - Park, H J AU - Komolprasert, V AD - Division of Food Processing and Packaging, U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501, and Rural Living Science Institute, 88-2 Seodundong, Suwon, Kor. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 5856 EP - 5859 VL - 48 IS - 12 SN - 0021-8561, 0021-8561 KW - Index Medicus KW - Reproducibility of Results KW - Chromatography, Gas KW - Ultrasonics KW - Paper KW - Food Contamination -- analysis KW - Food Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72602399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Analytical+procedure+for+quantifying+five+compounds+suspected+as+possible+contaminants+in+recycled+paper%2Fpaperboard+for+food+packaging.&rft.au=Song%2C+Y+S%3BPark%2C+H+J%3BKomolprasert%2C+V&rft.aulast=Song&rft.aufirst=Y&rft.date=2000-12-01&rft.volume=48&rft.issue=12&rft.spage=5856&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of organochlorine and organophosphorus pesticide residues in eggs using a solid phase extraction cleanup. AN - 72594478; 11141294 AB - A multiresidue solid phase extraction (SPE) method for the isolation and subsequent gas chromatographic determination of nonpolar organochlorine and polar organophosphorus pesticide residues in eggs is described. The method uses an acetonitrile extraction followed by an SPE cleanup using graphitized carbon black and aminopropyl SPE columns. Organophosphorus pesticides are determined by gas chromatography with flame photometric detection. After further cleanup of the extract using Florisil SPE columns, organochlorine pesticides are determined by gas chromatography with electron capture detection. Studies were performed using eggs containing both fortified and incurred pesticide residues. The average recoveries were 86-108% for 8 fortified organochlorine pesticide residues and 61-149% for 28 fortified organophosphorus pesticide residues. JF - Journal of agricultural and food chemistry AU - Schenck, F J AU - Donoghue, D J AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. fschenck@ora.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 6412 EP - 6415 VL - 48 IS - 12 SN - 0021-8561, 0021-8561 KW - Insecticides KW - 0 KW - Organophosphorus Compounds KW - Pesticide Residues KW - Index Medicus KW - Animals KW - Chickens KW - Female KW - Chromatography, Gas -- methods KW - Organophosphorus Compounds -- analysis KW - Pesticide Residues -- isolation & purification KW - Eggs -- analysis KW - Pesticide Residues -- analysis KW - Insecticides -- isolation & purification KW - Insecticides -- analysis KW - Organophosphorus Compounds -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72594478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+of+organochlorine+and+organophosphorus+pesticide+residues+in+eggs+using+a+solid+phase+extraction+cleanup.&rft.au=Schenck%2C+F+J%3BDonoghue%2C+D+J&rft.aulast=Schenck&rft.aufirst=F&rft.date=2000-12-01&rft.volume=48&rft.issue=12&rft.spage=6412&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biotransformation of vinclozolin by the fungus Cunninghamella elegans. AN - 72593997; 11312787 AB - This study investigated the biotransformation of the dicarboximide fungicide vinclozolin [3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione] by the fungus Cunninghamella elegans. Experiments with phenyl-[U-ring-14C]vinclozolin showed that after 96 h incubation, 93% had been transformed to four major metabolites. Metabolites were separated by HPLC and characterized by mass and NMR spectroscopy. Biotransformation occurred predominantly on the oxazolidine-2,4-dione portion of vinclozolin. The metabolites were identified as the 3R- and 3S- isomers of 3',5'-dichloro-2,3,4-trihydroxy-2-methylbutyranilide, N-(2-hydroxy-2-methyl-1-oxobuten-3-yl)-3,5-dichlorophenyl-1-carbamic acid, and 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide. The enanilide compound has been reported previously as a plant and mammalian metabolite and is implicated to contain antiandrogenic activity. The 3R- and 3S- isomers of 3',5'-dichloro-2,3,4-trihydroxy-2-methylbutyranilide are novel metabolites. JF - Journal of agricultural and food chemistry AU - Pothuluri, J V AU - Freeman, J P AU - Heinze, T M AU - Beger, R D AU - Cerniglia, C E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. JPothuluri@nctr.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 6138 EP - 6148 VL - 48 IS - 12 SN - 0021-8561, 0021-8561 KW - Fungicides, Industrial KW - 0 KW - Oxazoles KW - vinclozolin KW - JJ258EZN1I KW - Index Medicus KW - Biotransformation KW - Isomerism KW - Fungicides, Industrial -- pharmacokinetics KW - Oxazoles -- pharmacokinetics KW - Cunninghamella -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72593997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Biotransformation+of+vinclozolin+by+the+fungus+Cunninghamella+elegans.&rft.au=Pothuluri%2C+J+V%3BFreeman%2C+J+P%3BHeinze%2C+T+M%3BBeger%2C+R+D%3BCerniglia%2C+C+E&rft.aulast=Pothuluri&rft.aufirst=J&rft.date=2000-12-01&rft.volume=48&rft.issue=12&rft.spage=6138&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of total 14C residues of sarafloxacin in eggs of laying hens. AN - 72590367; 11141293 AB - [14C]sarafloxacin was orally administered to six laying hens for five consecutive days. Eggs were collected for 15 days after the initial drug treatment. Egg yolk and egg albumen were separated and assayed for total radioactive residues (TRR) using a combustion oxidizer and scintillation counting techniques. Radioactivity was detected in egg yolk and egg albumen on the second day of dosing and reached a maximum at 24 h after drug withdrawal. Thereafter, the sarafloxacin TRR levels in egg albumen declined rapidly and were undetectable 2 days after the last dose, whereas the levels in egg yolk declined at a much slower rate and were undetectable 7 days after drug withdrawal. In both the egg albumen and yolk, HPLC analysis indicated that the parent sarafloxacin was the major component. JF - Journal of agricultural and food chemistry AU - Chu, P S AU - Donoghue, D J AU - Shaikh, B AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. pchu@cmv.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 6409 EP - 6411 VL - 48 IS - 12 SN - 0021-8561, 0021-8561 KW - Anti-Infective Agents KW - 0 KW - Carbon Isotopes KW - Egg Proteins KW - Fluoroquinolones KW - Ciprofloxacin KW - 5E8K9I0O4U KW - sarafloxacin KW - RC3WJ907XY KW - Index Medicus KW - Administration, Oral KW - Animals KW - Drug Residues -- metabolism KW - Female KW - Chromatography, High Pressure Liquid KW - Egg Proteins -- analysis KW - Ciprofloxacin -- administration & dosage KW - Anti-Infective Agents -- pharmacokinetics KW - Ciprofloxacin -- pharmacokinetics KW - Egg Yolk -- chemistry KW - Anti-Infective Agents -- administration & dosage KW - Ciprofloxacin -- analogs & derivatives KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72590367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+of+total+14C+residues+of+sarafloxacin+in+eggs+of+laying+hens.&rft.au=Chu%2C+P+S%3BDonoghue%2C+D+J%3BShaikh%2C+B&rft.aulast=Chu&rft.aufirst=P&rft.date=2000-12-01&rft.volume=48&rft.issue=12&rft.spage=6409&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imaging residue transfer into egg yolks. AN - 72589469; 11141297 AB - Prediction models for residue transfer into eggs are being developed. Recent results indicate that the developing egg yolk serves as an important storage depot for chemical residues. The current study was conducted to visualize incorporation and potential compartmentalization of drug residues in developing egg yolks. To this end, the drug magnevist was injected into hens to evaluate drug transfer into either early- or late-developing yolks. High-resolution magnetic resonance images (MRI) of drug residues in eggs were acquired using a 1.5 T Siemens Magnetom clinical scanner. A 10-cm circular surface coil was used for receiving the magnetic resonance signal. The eggs were positioned inside the coil cavity for an improved signal to noise ratio (SNR). Gradient-echo images were used to locate the centers of the eggs and to prescribe the position of the high-resolution image slab. The images were recorded using an inversion time (T1) weighted magnetization-prepared, rapid acquisition, gradient-recalled-echo (MPRAGE) pulse sequence. The sequence parameters used were as follows: repetition time (TR) equals 12 ms, echo time (TE) equals 5 ms, field of view (FOV) equals 200, TI = 10 ms, 1.25-mm slice thickness, and a matrix of 200 x 256. Following dosing, images of drug residues in eggs indicate that drugs can be incorporated and compartmentalized into ring structures within individual developing egg yolks. These results have significant human food safety implications because even after only a single dose, sequestered drug residues may be stored and later released to contaminate eggs for days to weeks after dosing. JF - Journal of agricultural and food chemistry AU - Donoghue, D J AU - Myers, K AD - Division of Animal Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA. ddonoghue@comp.uark.edu Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 6428 EP - 6430 VL - 48 IS - 12 SN - 0021-8561, 0021-8561 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Chickens KW - Safety KW - Food Contamination -- analysis KW - Time Factors KW - Models, Biological KW - Female KW - Drug Residues -- analysis KW - Egg Yolk -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72589469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Imaging+residue+transfer+into+egg+yolks.&rft.au=Donoghue%2C+D+J%3BMyers%2C+K&rft.aulast=Donoghue&rft.aufirst=D&rft.date=2000-12-01&rft.volume=48&rft.issue=12&rft.spage=6428&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distribution of total 14C residue in egg yolk, albumen, and tissues following oral [14C]sulfamethazine administration to hens. AN - 72587438; 11141292 AB - The distribution of total 14C residues was studied in egg yolk and albumen after administration of either single or multiple oral dosages of [14C]sulfamethazine (SMZ). One day after a single dose of [14C]SMZ (121 mg of sulfamethazine, 2.42 x 10(7) dpm), the 14C residue concentration peaked in egg albumen and egg yolk with the concentration in the former >4-fold greater than in the latter. Three days postdose, the 14C residue concentration in the yolk was approximately 7-fold higher than in the egg albumen. A multiple dose of [14C]SMZ containing sulfamethazine mass equivalent of an average therapeutic dose (282 mg, 2.9 x 10(7) dpm) for chickens was also administered orally for six consecutive days to hens. A significantly reduced level of egg production was observed during the medication, and most of the hens stopped laying eggs after the last dose. The 14C residue concentrations peaked on the last day (sixth) of medication in egg albumen and yolk. The 14C residue concentrations were also measured in liver, muscle, blood, and plasma of chickens sacrificed at 1, 24, 48, and 72 h after the last dose. Highest concentrations of 14C residue were accumulated in liver followed by, in decreasing order, blood, plasma, and muscle. JF - Journal of agricultural and food chemistry AU - Shaikh, B AU - Chu, P S AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. bshaikh@cmv.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 6404 EP - 6408 VL - 48 IS - 12 SN - 0021-8561, 0021-8561 KW - Carbon Isotopes KW - 0 KW - Egg Proteins KW - Sulfamethazine KW - 48U51W007F KW - Index Medicus KW - Administration, Oral KW - Animals KW - Body Burden KW - Food Contamination KW - Drug Residues KW - Time Factors KW - Female KW - Egg Proteins -- analysis KW - Chickens -- physiology KW - Sulfamethazine -- administration & dosage KW - Egg Yolk -- chemistry KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72587438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Distribution+of+total+14C+residue+in+egg+yolk%2C+albumen%2C+and+tissues+following+oral+%5B14C%5Dsulfamethazine+administration+to+hens.&rft.au=Shaikh%2C+B%3BChu%2C+P+S&rft.aulast=Shaikh&rft.aufirst=B&rft.date=2000-12-01&rft.volume=48&rft.issue=12&rft.spage=6404&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurodevelopmental effects: making the case for biologic plausibility. AN - 72582494; 11233767 AB - It has been suggested that the most critical missing link between science and policy is causality; that is, the establishment of a definite cause-effect relationship between exposure and adverse health effects. As has been clearly demonstrated by the decades-long tobacco debate, causality is extremely difficult to establish with absolute certainty, particularly in the minds of scientists. Because of this, it has been suggested that a "weight of evidence" approach based on biologic plausibility should be used as a surrogate for causality when translating science into policy and public health practice. In the case of neurodevelopmental effects, the case for biologic plausibility is supported by scientific findings from three broad areas consisting of wildlife biology, toxicology, and epidemiology. A striking example of this is provided by research findings from the Great Lakes Basin, an area which has been the focus of significant scientific research for the last thirty years in these three broad areas. In this paper, we examine relevant findings from the Great Lakes Basin and elsewhere as they relate to establishing and supporting the biologic plausibility of neurodevelopmental effects associated with environmental exposures to persistent toxic substances. JF - Neurotoxicology AU - De Rosa, C T AU - Hicks, H E AU - Cibulas, W AU - Jones, D E AD - U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, USA. cydo@cdc.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 979 EP - 987 VL - 21 IS - 6 SN - 0161-813X, 0161-813X KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Animals KW - Great Lakes Region -- epidemiology KW - Humans KW - United States -- epidemiology KW - Environmental Illness -- epidemiology KW - Environmental Pollutants -- toxicity KW - Nervous System -- drug effects KW - Environmental Illness -- chemically induced KW - Nervous System -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72582494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Neurodevelopmental+effects%3A+making+the+case+for+biologic+plausibility.&rft.au=De+Rosa%2C+C+T%3BHicks%2C+H+E%3BCibulas%2C+W%3BJones%2C+D+E&rft.aulast=De+Rosa&rft.aufirst=C&rft.date=2000-12-01&rft.volume=21&rft.issue=6&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of single injection of methylazoxymethanol at postnatal day one on cell proliferation in different brain regions of male rats. AN - 72575977; 11233761 AB - Methylazoxymethanol (MAM), an aglycone of cycasin extracted from Cycad seed, is reported to induce microencephaly in rats after prenatal or postnatal administration. Forty postnatal day (PND) 1 rats derived from 8 timed-pregnant rats were used to evaluate the effect of a single subcutaneous injection of MAM on PND 1 on cell proliferation in rat brain. All dams were fed NIH-31 diet. In the MAM-treated group, each pup received a single injection of MAM at 10 mg/kg body weight. In the control group, pups were injected with saline solution. Body weight of pups was recorded on PNDs 1, 7, 14, 21, 28, and 60. One male pup in each litter was removed for sacrifice by decapitation on PNDs 7, 14, 21, 28, and 60. The brain was removed and dissected to obtain the brain stem, caudate nucleus, cerebellum, frontal cortex, hippocampus, hypothalamus, and olfactory bulb. The percentage (%) of S-phase cells in the cell cycle for each region was measured as index of cell proliferation. A significant (p<0. 05) reduction in body weight was detected on PND 7. The % S-phase cells in cerebellum on PND 7 and olfactory bulb on PND 14 initially increased and then later decreased. There were significant decreases in the % S-phase cells in both cerebellum and caudate nucleus on PND 21 and olfactory bulb on PND 28. No significant changes were found in other brain regions in cell proliferation activity between the control and MAM-treated groups. The % of S-phase cells in cerebellum decreased 65% on PND 60 but lacked statistical significance due to small number of animals used in each group. The results indicated that a single injection of MAM at 10 mg/kg/body weight on PND 1 inhibited cell proliferation in the cerebellum in a manner that could lead to microencephaly. JF - Neurotoxicology AU - Lu, M H AU - Tang, N AU - Ali, S F AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. mlu@nctr.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1145 EP - 1151 VL - 21 IS - 6 SN - 0161-813X, 0161-813X KW - Carcinogens KW - 0 KW - Methylazoxymethanol Acetate KW - 592-62-1 KW - methylazoxymethanol KW - JGG19N3YDQ KW - Index Medicus KW - Rats KW - Microcephaly -- pathology KW - Aging -- physiology KW - Animals KW - Rats, Sprague-Dawley KW - Microcephaly -- chemically induced KW - Cell Division -- drug effects KW - Flow Cytometry KW - Male KW - Cell Cycle -- drug effects KW - Methylazoxymethanol Acetate -- toxicity KW - Brain -- cytology KW - Brain -- drug effects KW - Carcinogens -- toxicity KW - Methylazoxymethanol Acetate -- analogs & derivatives KW - Brain -- growth & development KW - Animals, Newborn -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72575977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Effects+of+single+injection+of+methylazoxymethanol+at+postnatal+day+one+on+cell+proliferation+in+different+brain+regions+of+male+rats.&rft.au=Lu%2C+M+H%3BTang%2C+N%3BAli%2C+S+F&rft.aulast=Lu&rft.aufirst=M&rft.date=2000-12-01&rft.volume=21&rft.issue=6&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multigenerational exposure to dietary genistein has no severe effects on nursing behavior in rats. AN - 72575125; 11233769 AB - The phytoestrogen and principal isoflavone in soy, genistein, has adverse effects on reproductive physiology in rodents. Since physiology and behavior are both sensitive to perturbations by estrogens, genistein may produce behavioral alterations as well. This paper reports one aspect of a study in which several adult rodent behaviors will be assessed following long term multigenerational dietary exposure to genistein. Since maternal care may affect offspring behaviors in adulthood, it is important to determine the potential for genistein to affect maternal behavior. Here, rats (F0 generation) were fed soy-free diets containing 0, 5, 100, or 500 ppm genistein (approx. 0, 0.4, 8, and 40 mg/kg/day for an adult) beginning on postnatal day (PND) 42. Two generations of offspring (F1 and F2) were continued on these diets and all treatment groups of the F3 generation were returned to 0 ppm at weaning (PND 22). In the first 3 weeks after parturition (for each generation), dams were assessed on 6 occasions for the presence of the arched back posture with at least one pup nursing. Data were analyzed by 3 way repeated measures analysis of variance (ANOVA) with generation, treatment, and postnatal day as factors, and p<0.05 required for significance. There were no significant interactions among treatment, generation, or day, and no overall effects of treatment or generation. As expected, there was a significant overall effect of day, with animals nursing less on later days (p<0.0001). As assessed here, these results suggest that lifelong and multigenerational exposure to dietary genistein has no severe effects on nursing behavior in rodents. JF - Neurotoxicology AU - Flynn, K M AU - Ferguson, S A AU - Delclos, K B AU - Newbold, R R AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. kflynn@nctr.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 997 EP - 1001 VL - 21 IS - 6 SN - 0161-813X, 0161-813X KW - Anticarcinogenic Agents KW - 0 KW - Estrogens, Non-Steroidal KW - Isoflavones KW - Phytoestrogens KW - Plant Preparations KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Diet KW - Male KW - Female KW - Anticarcinogenic Agents -- toxicity KW - Lactation -- drug effects KW - Estrogens, Non-Steroidal -- toxicity KW - Genistein -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72575125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Multigenerational+exposure+to+dietary+genistein+has+no+severe+effects+on+nursing+behavior+in+rats.&rft.au=Flynn%2C+K+M%3BFerguson%2C+S+A%3BDelclos%2C+K+B%3BNewbold%2C+R+R&rft.aulast=Flynn&rft.aufirst=K&rft.date=2000-12-01&rft.volume=21&rft.issue=6&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reducing environmental risk associated with laboratory decommissioning and property transfer. AN - 72532746; 11121365 AB - The need for more or less space is a common laboratory problem. Solutions may include renovating existing space, leaving or demolishing old space, or acquiring new space or property for building. All of these options carry potential environmental risk. Such risk can be the result of activities related to the laboratory facility or property (e.g., asbestos, underground storage tanks, lead paint), or the research associated with it (e.g., radioactive, microbiological, and chemical contamination). Regardless of the option chosen to solve the space problem, the potential environmental risk must be mitigated and the laboratory space and/or property must be decommissioned or rendered safe prior to any renovation, demolition, or property transfer activities. Not mitigating the environmental risk through a decommissioning process can incur significant financial liability for any costs associated with future decommissioning cleanup activities. Out of necessity, a functioning system, environmental due diligence auditing, has evolved over time to assess environmental risk and reduce associated financial liability. This system involves a 4-phase approach to identify, document, manage, and clean up areas of environmental concern or liability, including contamination. Environmental due diligence auditing includes a) historical site assessment, b) characterization assessment, c) remedial effort and d) final status survey. General practice standards from the American Society for Testing and Materials are available for conducting the first two phases. However, standards have not yet been developed for conducting the third and final phases of the environmental due diligence auditing process. Individuals involved in laboratory decommissioning work in the biomedical research industry consider this a key weakness. JF - Environmental health perspectives AU - Dufault, R AU - Abelquist, E AU - Crooks, S AU - Demers, D AU - DiBerardinis, L AU - Franklin, T AU - Horowitz, M AU - Petullo, C AU - Sturchio, G AD - Division of Facilities Planning, Engineerinf and Safety, United States Food and Drug Administration, Rockville, Maryland 20857, USA. rdufault@oc.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1015 EP - 1022 VL - 108 Suppl 6 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Workplace KW - Materials Testing KW - Manufactured Materials KW - Liability, Legal KW - Air Pollution, Indoor -- prevention & control KW - Biomedical Technology KW - Risk Assessment KW - Laboratories KW - Facility Design and Construction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72532746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Reducing+environmental+risk+associated+with+laboratory+decommissioning+and+property+transfer.&rft.au=Dufault%2C+R%3BAbelquist%2C+E%3BCrooks%2C+S%3BDemers%2C+D%3BDiBerardinis%2C+L%3BFranklin%2C+T%3BHorowitz%2C+M%3BPetullo%2C+C%3BSturchio%2C+G&rft.aulast=Dufault&rft.aufirst=R&rft.date=2000-12-01&rft.volume=108+Suppl+6&rft.issue=&rft.spage=1015&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-20 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Infect Control. 1996 Aug;24(4):313-42 [8870916] Appl Occup Environ Hyg. 1999 Jun;14(6):369-75 [10429731] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of verbal communication problems and indoor environmental quality at a government service office. AN - 72516612; 11141598 JF - Applied occupational and environmental hygiene AU - Tubbs, R L AU - Seitz, T A AD - Hazard Evaluation and Technical Assistance Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 869 EP - 878 VL - 15 IS - 12 SN - 1047-322X, 1047-322X KW - Index Medicus KW - Occupational Health KW - Government KW - Ventilation KW - Voice KW - Humans KW - Air Pollution, Indoor KW - Noise KW - Communication KW - Facility Design and Construction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72516612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Evaluation+of+verbal+communication+problems+and+indoor+environmental+quality+at+a+government+service+office.&rft.au=Tubbs%2C+R+L%3BSeitz%2C+T+A&rft.aulast=Tubbs&rft.aufirst=R&rft.date=2000-12-01&rft.volume=15&rft.issue=12&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serum organochlorine levels and breast cancer: a nested case-control study of Norwegian women. AN - 72512552; 11142422 AB - This study investigated the potential association between organochlorine exposure and breast cancer using stored sera collected from 1973 through 1991 from the Janus Serum Bank in Norway. Breast cancer cases were ascertained prospectively from among 25,431 female serum bank donors. A total of 150 controls were matched to cases by birth dates and dates of sample collection. One g of serum per subject was analyzed for a total of 71 organochlorine compounds. For 6 pesticides [B-hexachlorocyclohexane, heptachlor epoxide, oxychlordane, trans-nonachlor, p, p'-1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, and p, p'-2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] and 26 individual polychlorinated biphenyl (PCB) congeners there were >90% of samples over the limit of detection. There was no evidence for higher mean serum levels among cases for any of these compounds, nor any trend of increasing risk associated with higher quartiles of exposure. The remaining compounds (including dieldrin) were analyzed with respect to the proportion of cancer cases and controls having detectable levels; no positive associations were noted in these analyses. Our study did not confirm the recent findings of a Danish study of increased concentrations of dieldrin in the serum of breast cancer cases. The evidence to date on the association between serum organochlorines is not entirely consistent, but there is accumulating evidence that serum levels of p, p'-1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and total PCBs are not important predictors for breast cancer in the general population. Studies to date have not been able to evaluate whether exposure to highly estrogenic, short-lived PCB congeners increases breast cancer risk, nor have they fully evaluated the risk associated with organochlorine exposure in susceptible subgroups or at levels above general population exposure, including women with occupational exposure. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Ward, E M AU - Schulte, P AU - Grajewski, B AU - Andersen, A AU - Patterson, D G AU - Turner, W AU - Jellum, E AU - Deddens, J A AU - Friedland, J AU - Roeleveld, N AU - Waters, M AU - Butler, M A AU - DiPietro, E AU - Needham, L L AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1357 EP - 1367 VL - 9 IS - 12 SN - 1055-9965, 1055-9965 KW - Insecticides KW - 0 KW - Receptors, Estrogen KW - Receptors, Progesterone KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Regression Analysis KW - Age Factors KW - Blood Banks -- statistics & numerical data KW - Humans KW - Receptors, Estrogen -- analysis KW - Receptors, Progesterone -- analysis KW - Prospective Studies KW - Adult KW - Polychlorinated Biphenyls -- blood KW - Case-Control Studies KW - Middle Aged KW - Adolescent KW - Norway KW - Female KW - Adenocarcinoma -- blood KW - Adenocarcinoma -- chemically induced KW - Breast Neoplasms -- chemically induced KW - Breast Neoplasms -- blood KW - Insecticides -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72512552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Serum+organochlorine+levels+and+breast+cancer%3A+a+nested+case-control+study+of+Norwegian+women.&rft.au=Ward%2C+E+M%3BSchulte%2C+P%3BGrajewski%2C+B%3BAndersen%2C+A%3BPatterson%2C+D+G%3BTurner%2C+W%3BJellum%2C+E%3BDeddens%2C+J+A%3BFriedland%2C+J%3BRoeleveld%2C+N%3BWaters%2C+M%3BButler%2C+M+A%3BDiPietro%2C+E%3BNeedham%2C+L+L&rft.aulast=Ward&rft.aufirst=E&rft.date=2000-12-01&rft.volume=9&rft.issue=12&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A laboratory comparison of two media for use in the assessment of dermal exposure to pesticides. AN - 72512386; 11141607 AB - In a laboratory study, gauze pads and Empore filters were compared for their ability to assess the dermal exposure of two insecticides (chlorpyrifos and diazinon) and five herbicides (atrazine, alachlor, metolachlor, cyanazine, and 2,4-D ethylhexyl ester). The analytes, when analyzed by gas chromatography with flame ionization detection, were found to have a linear dynamic range to at least 250 micrograms/mL. While a number of different solvents were examined for the desorption of the analytes, methanol was found to be the best solvent for the recovery of all the analytes from 16-ply gauze pads, while 20 percent ethyl acetate in hexane was the preferred solvent for the styrene divinylbenzene-impregnated Empore filters. Limits of detection (LODs) for the analytes were comparable for both media. For Empore filters, the LODs were 50 micrograms/sample for atrazine, alachlor, chlorpyrifos, diazinon, and 2,4-D ethylhexy ester, with 30 micrograms/sample for metolachlor, and 80 micrograms/sample for cyanazine. For gauze pads, the LODs were 40 micrograms/sample for metolachlor, 50 micrograms/sample for alachlor, diazinon, and 2,4-D ethylhexy ester, 60 micrograms/sample for atrazine and chlorpyrifos, and 80 micrograms/sample for cyanazine. Both gauze pads and Empore filters gave quantitative recovery for all analytes except chlorpyrifos and 2,4-D ethylhexyl ester under ambient conditions (18 degrees C, 70% relative humidity) for up to 30 days; these analytes required refrigeration for that period to reach over 90 percent recovery. To assess the effect of environmental conditions on the recovery of the analytes, samples of each media were spiked at about 125 micrograms per analyte/sample (except cyanazine which was spiked at 190 micrograms) and challenged for 8 hr under high (80%) and low (20%) humidity and high (40 degrees C) and low (5 degrees C) temperature conditions in an environmental chamber. While the Empore samples gave quantitative recovery after being challenged, recovery from the gauze pads was affected by environmental conditions, especially high temperature. Recovery from gauze pads was below 30 percent for some analytes under high temperature/high humidity conditions. JF - Applied occupational and environmental hygiene AU - Lorberau, C D AU - Pride, J L AD - Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 946 EP - 950 VL - 15 IS - 12 SN - 1047-322X, 1047-322X KW - Insecticides KW - 0 KW - Solvents KW - Chlorpyrifos KW - JCS58I644W KW - Diazinon KW - YUS1M1Q929 KW - Index Medicus KW - Sensitivity and Specificity KW - Filtration KW - Administration, Cutaneous KW - Humans KW - Temperature KW - Specimen Handling KW - Humidity KW - Chlorpyrifos -- analysis KW - Diazinon -- analysis KW - Insecticides -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72512386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=A+laboratory+comparison+of+two+media+for+use+in+the+assessment+of+dermal+exposure+to+pesticides.&rft.au=Lorberau%2C+C+D%3BPride%2C+J+L&rft.aulast=Lorberau&rft.aufirst=C&rft.date=2000-12-01&rft.volume=15&rft.issue=12&rft.spage=946&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to mercury vapor during the use of mercury carburetor synchronizers. AN - 72512246; 11147491 JF - Applied occupational and environmental hygiene AU - National Institute for Occupational Safety and Health AD - National Institute for Occupational Safety and Health Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 900 EP - 901 VL - 15 IS - 12 SN - 1047-322X, 1047-322X KW - Vehicle Emissions KW - 0 KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Equipment Design KW - Air Pollution, Indoor -- analysis KW - Ventilation KW - Humans KW - Mercury -- analysis KW - Occupational Exposure -- analysis KW - Motor Vehicles KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72512246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Exposure+to+mercury+vapor+during+the+use+of+mercury+carburetor+synchronizers.&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2000-12-01&rft.volume=15&rft.issue=12&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls. AN - 72506645; 11221602 AB - Cytochrome P4501B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones, including 17beta-oestradiol (E2) and testosterone. We report a significant difference in the allele frequencies of two point mutations in the coding region of the CYP1B1 gene among Caucasian (n = 189), African-American (n = 52) and Chinese (Linxian) (n = 109) populations. A (C to G) transversion at position 1666 in exon 3, which results in an amino acid substitution of Leu432 to Val, was present in African-Americans with an allele frequency for Va1432 of 0.75, in Caucasians of 0.43, and in Chinese of 0.17. A (C to T) transition at position 1719 in exon 3, with no amino acid change (Asp449), appeared to be closely linked with the Val432 variant. Results using human lung microsomal preparations from individuals with the CYP1B1Val/Val and CYP1B1Leu/Leu genotypes indicate that Val432 variant may be a high activity allele and thus may contribute to the interindividual differences in CYP1B1 activity. Because CYP1B1 is involved in hormone and carcinogen metabolism, and given the disparate rates of prostate cancer among ethnic groups, we also evaluated the association of the CYP1B1 Leu432Val polymorphism with prostate cancer risk in a pilot case-control study. Among Caucasians, 34% of men with cancer (n = 50) were homozygous for the Val432 polymorphism, while only 12% of matched control subjects (n = 50) had this genotype. These preliminary data indicate that genetic polymorphisms in CYP1B1 might play an important role in human prostate carcinogenesis. JF - Pharmacogenetics AU - Tang, Y M AU - Green, B L AU - Chen, G F AU - Thompson, P A AU - Lang, N P AU - Shinde, A AU - Lin, D X AU - Tan, W AU - Lyn-Cook, B D AU - Hammons, G J AU - Kadlubar, F F AD - Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 761 EP - 766 VL - 10 IS - 9 SN - 0960-314X, 0960-314X KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Steroid Hydroxylases KW - EC 1.14.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - estrogen 2-hydroxylase KW - Index Medicus KW - Humans KW - African Americans KW - Aged KW - Microsomes -- enzymology KW - Asian Continental Ancestry Group -- genetics KW - European Continental Ancestry Group -- genetics KW - Polymerase Chain Reaction KW - African Continental Ancestry Group -- genetics KW - Aged, 80 and over KW - China -- epidemiology KW - Adult KW - Middle Aged KW - Lung -- enzymology KW - Male KW - Continental Population Groups -- genetics KW - Polymorphism, Restriction Fragment Length KW - Cytochrome P-450 Enzyme System -- genetics KW - Prostatic Neoplasms -- genetics KW - Steroid Hydroxylases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72506645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics&rft.atitle=Human+CYP1B1+Leu432Val+gene+polymorphism%3A+ethnic+distribution+in+African-Americans%2C+Caucasians+and+Chinese%3B+oestradiol+hydroxylase+activity%3B+and+distribution+in+prostate+cancer+cases+and+controls.&rft.au=Tang%2C+Y+M%3BGreen%2C+B+L%3BChen%2C+G+F%3BThompson%2C+P+A%3BLang%2C+N+P%3BShinde%2C+A%3BLin%2C+D+X%3BTan%2C+W%3BLyn-Cook%2C+B+D%3BHammons%2C+G+J%3BKadlubar%2C+F+F&rft.aulast=Tang&rft.aufirst=Y&rft.date=2000-12-01&rft.volume=10&rft.issue=9&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics&rft.issn=0960314X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enzyme inhibition and enzyme-linked immunosorbent assay methods for carbamate pesticide residue analysis in fresh produce. AN - 72505820; 11131904 AB - An acetylcholinesterase inhibition method was employed for detection of 21 carbamate pesticides in bananas, peaches, strawberries, and tomatoes. Each of these four agricultural commodities was spiked with 0.1 to 10 ppm of each of the 21 carbamates and individual detection levels were determined. Similar responses and detection limits were observed for all four produce when tested for a given carbamate. The detection levels ranged from 0.1 ppm for carbofuran and 3-hydroxycarbofuran to 6 ppm for promecarb and aldicarb sulfoxide. These results are generally at or below the tolerances established by the Environmental Protection Agency for these commodities. Positive samples from the enzyme inhibition screening were also analyzed with the carbaryl-specific enzyme-linked immunosorbent assay (ELISA) kit. The detection limits for carbaryl and carbofuran were 2.0 ppb and 8.0 ppb, respectively. The other carbamates did not exhibit cross-reactivity even at high ppb levels. Thus, the enzyme inhibition assay and ELISA are simple and fast screening procedures for the detection of carbamate pesticide residues in food commodities. JF - Journal of food protection AU - Katsoudas, E AU - Abdelmesseh, H H AD - U.S. Food and Drug Administration, Northeast Regional Laboratory, Jamaica, New York 11433, USA. ekatsoud@ora.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1758 EP - 1760 VL - 63 IS - 12 SN - 0362-028X, 0362-028X KW - Carbamates KW - 0 KW - Enzyme Inhibitors KW - Pesticide Residues KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Food Analysis KW - Food Contamination KW - Carbamates -- analysis KW - Pesticide Residues -- analysis KW - Fruit -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Enzyme+inhibition+and+enzyme-linked+immunosorbent+assay+methods+for+carbamate+pesticide+residue+analysis+in+fresh+produce.&rft.au=Katsoudas%2C+E%3BAbdelmesseh%2C+H+H&rft.aulast=Katsoudas&rft.aufirst=E&rft.date=2000-12-01&rft.volume=63&rft.issue=12&rft.spage=1758&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2000-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotoxicology: role of inflammation in chemical-induced hepatotoxicity. AN - 72472289; 11137622 AB - The liver, which is the major organ responsible for the metabolism of drugs and chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators which can effect liver damage or repair. This review will summarize the authors' current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride (CCl4), an industrial chemical, and acetaminophen (APAP), a widely used analgesic. JF - International journal of immunopharmacology AU - Luster, M I AU - Simeonova, P P AU - Gallucci, R M AU - Matheson, J M AU - Yucesoy, B AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. mluster@cdc.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1143 EP - 1147 VL - 22 IS - 12 SN - 0192-0561, 0192-0561 KW - Inflammation Mediators KW - 0 KW - Index Medicus KW - Animals KW - Necrosis KW - Humans KW - Inflammation Mediators -- physiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72472289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Immunotoxicology%3A+role+of+inflammation+in+chemical-induced+hepatotoxicity.&rft.au=Luster%2C+M+I%3BSimeonova%2C+P+P%3BGallucci%2C+R+M%3BMatheson%2C+J+M%3BYucesoy%2C+B&rft.aulast=Luster&rft.aufirst=M&rft.date=2000-12-01&rft.volume=22&rft.issue=12&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hazard surveillance for industrial magnetic fields: I. Walkthrough survey of ambient fields and sources. AN - 72470068; 11108783 AB - A walkthrough survey method was developed for measuring ambient magnetic fields (MFs) in industrial facilities as the first stage in hazard surveillance. This survey was designed to measure the mean and peak MF magnitudes at extremely low frequencies (ELFs), so that factories could be ranked by MF levels and prioritized for subsequent personal exposure monitoring. Sixty-two facilities from 13 Standard Industrial Classifications (SICs) with the highest monthly electric power usage were surveyed. To measure ambient MFs, a structured walkthrough survey with a special emphasis on workstations was conducted with an EMDEX-II meter in continuous operation, while MF sources were noted. The broadband MF data (40-800Hz) for each facility were summarized with the geometric mean (GM) and the average of the five highest readings (Hi-5). The range of the GM magnetic field magnitude was 0.04-1.61microT, where the maximum was measured at a steel mill operating large electric furnaces. Maximum values for specific sources were highly variable across and within facilities (Hi-5 range: 1.0-530 microT). Chemical and Allied Products (SIC 28) and Primary Metal Products (SIC 33) had facilities with GM and Hi-5 magnetic fields greater than any of the other industrial categories. However, the SIC categories were found to be poor predictors of the ambient MF in this sample of factories. A weak relationship was found between the facility-specific monthly electric power consumption and the GM magnetic field magnitude, but confidence limits were too broad to make meaningful exposure predictions from electric power data. Overall, 89% of the GMs were at or below 0.4 microT, consistent with most other studies that collected industrial MF exposure data. The walkthrough survey is a practical way of measuring ambient MFs in a large number of workplaces, and should be evaluated with personal measurements as a screening method for hazard surveillance. JF - The Annals of occupational hygiene AU - Methner, M M AU - Bowman, J D AD - National Institute for Occupational Safety and Health (Mail Stop R-19), 4676 Columbia Parkway, OH 45226, Cincinnati, USA. mmm5@cdc.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 603 EP - 614 VL - 44 IS - 8 SN - 0003-4878, 0003-4878 KW - Index Medicus KW - United States KW - Regression Analysis KW - Power Plants KW - Electric Power Supplies KW - Humans KW - Electronics KW - Metallurgy KW - Industry KW - Occupational Exposure -- prevention & control KW - Electromagnetic Fields KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72470068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Hazard+surveillance+for+industrial+magnetic+fields%3A+I.+Walkthrough+survey+of+ambient+fields+and+sources.&rft.au=Methner%2C+M+M%3BBowman%2C+J+D&rft.aulast=Methner&rft.aufirst=M&rft.date=2000-12-01&rft.volume=44&rft.issue=8&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hazard surveillance for industrial magnetic fields: II. Field characteristics from waveform measurements. AN - 72465438; 11108784 AB - Magnetic field characteristics have been surveyed systematically in six factories with the Multiwave(R) II waveform capture instrument. These six facilities manufactured plastics, pharmaceuticals, cement, liquid air products, aluminum parts, and aluminum-framed filters. The study goals were to survey the physical characteristics of magnetic fields that may be related to biological effects under various interaction mechanisms and to relate those characteristics to the field's sources. From 59 waveform measurements at worker locations near sources, we calculated the extremely low frequency (ELF) and static field magnitudes, their frequency characteristics, and spatial characteristics of the 60Hz component. The RMS vector magnitude of the ELF magnetic field (the usual exposure metric in most studies) had medians ranging from 0.53 to 12.83 microT in the six factories. The static magnetic field magnitudes had medians of 24.2-46.2 microT, which is well below the geomagnetic reference field of 55.0 microT because of shielding from steel structures. The maximum static field was 128.6 microT near a DC motor. The frequency spectra of the most common fields is dominated by 60Hz, and has a median total harmonic distortion equal to 14.8%. The most common higher frequencies are the third, fifth, and second harmonics of 60Hz. However, magnetic fields in these workplaces had many other 60Hz harmonics and non-harmonic frequencies due particularly to electric motors and computer monitors. The 60Hz component magnetic fields have elliptical polarization with median axial ratio of 25.4%. The average proportion of the 60Hz component parallel to the static field vector was 51.5+/-3.0%, which indicates a significant trend towards perpendicular orientation between these two field components. In this survey of only six factories, the Multiwave(R) II measurements documented a wide diversity of complex magnetic field characteristics and non-sinusoidal waveforms. Although these characteristics are important to the various mechanisms postulated to explain biological effects, they are overlooked by the popular exposure assessment methods which only measure the ELF magnitude. Therefore, spot measurements with the Multiwave(R) II or similar waveform capture instruments are necessary for a complete magnetic field exposure assessment. JF - The Annals of occupational hygiene AU - Bowman, J D AU - Methner, M M AD - National Institute for Occupational Safety and Health (Mail Stop C-27), 4676 Columbia Parkway, OH 45226, Cincinnati, USA. jb60@cdc.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 615 EP - 633 VL - 44 IS - 8 SN - 0003-4878, 0003-4878 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Occupational Exposure -- prevention & control KW - Electromagnetic Fields KW - Fourier Analysis KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72465438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Hazard+surveillance+for+industrial+magnetic+fields%3A+II.+Field+characteristics+from+waveform+measurements.&rft.au=Bowman%2C+J+D%3BMethner%2C+M+M&rft.aulast=Bowman&rft.aufirst=J&rft.date=2000-12-01&rft.volume=44&rft.issue=8&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cognitive tests: interpretation for neurotoxicity? (Workshop summary). AN - 72437295; 11099635 AB - The appropriate use and interpretation of cognitive tests presents important challenges to the toxicologist and to the risk assessor. For example, intelligence cannot be measured directly; rather intelligence is quantified indirectly by scoring responses (i.e., behaviors) to specific situations (problems). This workshop, "Cognitive Tests: Interpretation for Neurotoxicity?" provided an overview on the types of cognitive tests available and described approaches by which the validity of such tests can be assessed. Unlike many tools available to the toxicologist, cognitive tests have a particular advantage. Being noninvasive and species-neutral, the same test can be performed in different mammalian species. This enhances one's ability to assess the validity of test results. Criteria for test validity include comparable responses across species as well as similar disruption by the same neurotoxicant across species. Test batteries, such as the Operant Test Battery, have indicated remarkable similarity between monkeys and children with respect to performance of certain tasks involving, for example, short-term memory. Still, there is a need for caution in interpretation of such tests. In particular, cognitive tests, especially when performed in humans, are subject to confounding by a range of factors, including age, gender, and, in particular, education. Moreover, the ability of such tests to reflect intelligence must be considered. Certain aspects of intelligence, such as the ability to plan or carry out specific tasks, are not well reflected by many of the standard tests of cognition. Nonetheless, although still under development, cognitive tests do hold promise for reliably predicting neurotoxicity in humans. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Slikker, W AU - Beck, B D AU - Cory-Slechta, D A AU - Paule, M G AU - Anger, W K AU - Bellinger, D AD - National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 222 EP - 234 VL - 58 IS - 2 SN - 1096-6080, 1096-6080 KW - Index Medicus KW - Behavior, Animal -- drug effects KW - Animals KW - Humans KW - Cognition -- drug effects KW - Brain -- drug effects KW - Toxicology -- methods KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72437295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Cognitive+tests%3A+interpretation+for+neurotoxicity%3F+%28Workshop+summary%29.&rft.au=Slikker%2C+W%3BBeck%2C+B+D%3BCory-Slechta%2C+D+A%3BPaule%2C+M+G%3BAnger%2C+W+K%3BBellinger%2C+D&rft.aulast=Slikker&rft.aufirst=W&rft.date=2000-12-01&rft.volume=58&rft.issue=2&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational skin diseases. AN - 72407457; 11072293 AB - Primary care physicians will likely see a wide variety of occupational skin diseases in their practices, including allergic contact dermatitis, irritant contact dermatitis, contact urticaria, a variety of infectious diseases, and skin cancers. The ideal role of a medical practitioner involved in occupational dermatology is not only to diagnose and treat patients, but also to determine the cause of the occupational skin disease and to make recommendations for its prevention. Making the diagnosis and offering treatment, determining the cause, and recommending measures can be difficult undertakings. JF - Primary care AU - Lushniak, B D AD - US Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 895 EP - 916 VL - 27 IS - 4 SN - 0095-4543, 0095-4543 KW - Index Medicus KW - Occupational Health KW - Cost of Illness KW - Public Health Practice KW - Risk Factors KW - Humans KW - Primary Prevention -- methods KW - United States -- epidemiology KW - Dermatitis, Occupational -- diagnosis KW - Dermatitis, Occupational -- etiology KW - Dermatology -- methods KW - Physician's Role KW - Primary Health Care -- methods KW - Dermatitis, Occupational -- therapy KW - Occupational Medicine -- methods KW - Dermatitis, Occupational -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72407457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Primary+care&rft.atitle=Occupational+skin+diseases.&rft.au=Lushniak%2C+B+D&rft.aulast=Lushniak&rft.aufirst=B&rft.date=2000-12-01&rft.volume=27&rft.issue=4&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Primary+care&rft.issn=00954543&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a fungus-specific PCR assay for detecting low-level fungi in an indoor environment. AN - 70772997; 11090263 AB - A fungus-specific PCR assay using only one primer set has been developed for detecting indoor fungi. Four fungal primer sets, NS3/NS4, NS5/NS6, FF1/FR1 and FF2/FR1, were tested with DNA from humans, rats, mice, bacteria, pollens and six commonly found fungal species (Alternaria chamydospora, Aspergillus flavus, Candida famata, Cladosporium fermentans, Penicillium chrycoIgenum and Stachybotrys chartarum). Results indicated that, although all four primer sets could amplify the fungal DNA, only FF2/FR1 demonstrated no cross-amplification with non-fungal DNA. In addition, these amplified fragments were sequenced to ensure that they indeed matched known fungal DNA sequences. Furthermore, besides the tested fungi, eighteen more genera of fungal sequences were examined and found to match the FF2/FR1. Here, the method of bead-beating was identified as the most effective way for spore breakage and fungal DNA release. The PCR amplification efficiency and potential inhibition were examined using different process solutions and preparation procedures. It was found that, when using 20% nutrient media and homogenization-first procedure, a higher amplification efficiency with less inhibition was achieved. Although positive bands were observed at 0.2 fungal spore/reaction using the homogenization-first procedure, the sensitivity of this assay would be two fungal spores/reaction for environmental samples. Copyright 2000 Academic Press. JF - Molecular and cellular probes AU - Zhou, G AU - Whong, W Z AU - Ong, T AU - Chen, B AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, WV 26505-2845, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 339 EP - 348 VL - 14 IS - 6 SN - 0890-8508, 0890-8508 KW - DNA Primers KW - 0 KW - DNA, Fungal KW - DNA, Ribosomal KW - Index Medicus KW - Sensitivity and Specificity KW - Rats KW - Pollen -- genetics KW - Animals KW - Humans KW - Spores, Fungal -- genetics KW - Electrophoresis, Agar Gel KW - Mice KW - DNA Primers -- chemistry KW - DNA, Fungal -- isolation & purification KW - DNA, Fungal -- analysis KW - DNA, Ribosomal -- isolation & purification KW - Air Pollution, Indoor -- analysis KW - Polymerase Chain Reaction -- methods KW - Fungi -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70772997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+probes&rft.atitle=Development+of+a+fungus-specific+PCR+assay+for+detecting+low-level+fungi+in+an+indoor+environment.&rft.au=Zhou%2C+G%3BWhong%2C+W+Z%3BOng%2C+T%3BChen%2C+B&rft.aulast=Zhou&rft.aufirst=G&rft.date=2000-12-01&rft.volume=4&rft.issue=&rft.spage=1339&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiplex PCR for detection of trait and virulence factors in enterohemorrhagic Escherichia coli serotypes. AN - 70764345; 11090262 AB - A multiplex PCR assay was developed which allowed the simultaneous detection of five trait genes or virulence markers in enterohemorrhagic Escherichia coli (EHEC) serotypes. A primer pair, designed to detect a single base-pair mutation in the uidA gene, is specific only for the prototypic EHEC of O157:H7 serotype and its toxigenic, non-motile variants. In a similar way, primers to the eaeA gene of the gamma-intimin derivative specifically detects strains in the EHEC 1 clonal group, which consists mostly of O157:H7 and some O55:H7 serotypes. The other three primer pairs, specific for stx1, stx2 and both variants of ehxA genes, will detect the presence of these virulence genes in all EHEC serotypes. Analysis of 34 strains, including various serotypes of EHEC, Shiga toxin-producing E. coli and enteropathogenic E. coli, confirmed that the multiplex PCR assay detected the presence of these genes in a manner consistent with the known genotype of each respective strains. Copyright 2000 Academic Press. JF - Molecular and cellular probes AU - Feng, P AU - Monday, S R AD - Division of Microbiological Studies, US Food and Drug Administration, Washington DC 20204, USA. pfeng@cfsan.fda.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 333 EP - 337 VL - 14 IS - 6 SN - 0890-8508, 0890-8508 KW - Bacterial Proteins KW - 0 KW - DNA Primers KW - Escherichia coli Proteins KW - Hemolysin Proteins KW - Hlya protein, E coli KW - Shiga Toxin 2 KW - Shiga Toxin KW - 75757-64-1 KW - Index Medicus KW - Polymerase Chain Reaction KW - Genetic Variation KW - Electrophoresis, Agar Gel KW - Serotyping KW - DNA Primers -- chemistry KW - Shiga Toxin 2 -- genetics KW - Bacterial Proteins -- genetics KW - Virulence -- genetics KW - Shiga Toxin -- genetics KW - Multifactorial Inheritance -- genetics KW - Hemolysin Proteins -- genetics KW - Escherichia coli O157 -- immunology KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70764345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+probes&rft.atitle=Multiplex+PCR+for+detection+of+trait+and+virulence+factors+in+enterohemorrhagic+Escherichia+coli+serotypes.&rft.au=Feng%2C+P%3BMonday%2C+S+R&rft.aulast=Feng&rft.aufirst=P&rft.date=2000-12-01&rft.volume=14&rft.issue=6&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+probes&rft.issn=08908508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Club Drugs. The DAWN Report. AN - 62349779; ED448388 AB - This report was prepared in response to requests from the media, law enforcement, and community leaders for information about club drugs. By being able to utilize statistics from hospital emergency departments and by compiling statistics on drug-related deaths, the Drug Abuse Warning Network (DAWN) is able to alert parents, educators, and others involved in the education of young adults about the danger of these drugs. An increased interest in club drugs follows recent publications of the use and effects of these drugs. Six drugs known as club drugs are highlighted in this report. They are: (1) d-lysergic acid diethylamide (LSD); (2) Gamma-hydroxy butyrate (GHB); (3) Ketamine; (4) methamphetamine; (5) methylenedioxymethamphetamine (Ecstasy); and (6) Rohypnol. According to DAWN, most emergency department episodes involving club drugs also involve other drugs. Club drugs are predominately used by adults under 25 years of age and whites make up 61% of all emergency department episodes. The report contains background information about the drugs, followed by trends in drug use for the years 1994-1998. Tables are used to describe trends in club drugs in multi-drug emergency department visits, and drug related deaths. Demographic characteristics of emergency department cases are described along with at look at the metropolitan areas where they occurred. (JDM) Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 11 KW - Emergency Medical Services KW - ERIC, Resources in Education (RIE) KW - Demography KW - Prevention KW - Elementary Secondary Education KW - Drug Education KW - Young Adults KW - Illegal Drug Use KW - Adolescents KW - Hospitals KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62349779?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - The study of TSP, PM (sub 2.5-10) and PM (sub 2.5) during Taiwan Chi-Chi earthquake in the traffic site of central Taiwan, Taichung AN - 52269635; 2001-015836 JF - Chemosphere (Oxford) AU - Fang, Guor-Cheng AU - Chang, Cheng-Nan AU - Wang, Nai-Phon AU - Wu, Yuh-Shen AU - Wang, Vicky AU - Fu, Peter Pi-Cheng AU - Cheng, Chii-Dong AU - Chen, Shun-Chin AU - Lin, Don-Yee Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1727 EP - 1731 PB - Pergamon, Oxford VL - 41 IS - 11 SN - 0045-6535, 0045-6535 KW - central Taiwan KW - concentration KW - Taiwan KW - particulate matter KW - Far East KW - Taichung Taiwan KW - pollution KW - suspended materials KW - sampling KW - Chi-Chi earthquake 1999 KW - air KW - Asia KW - earthquakes KW - instruments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52269635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere+%28Oxford%29&rft.atitle=The+study+of+TSP%2C+PM+%28sub+2.5-10%29+and+PM+%28sub+2.5%29+during+Taiwan+Chi-Chi+earthquake+in+the+traffic+site+of+central+Taiwan%2C+Taichung&rft.au=Fang%2C+Guor-Cheng%3BChang%2C+Cheng-Nan%3BWang%2C+Nai-Phon%3BWu%2C+Yuh-Shen%3BWang%2C+Vicky%3BFu%2C+Peter+Pi-Cheng%3BCheng%2C+Chii-Dong%3BChen%2C+Shun-Chin%3BLin%2C+Don-Yee&rft.aulast=Fang&rft.aufirst=Guor-Cheng&rft.date=2000-12-01&rft.volume=41&rft.issue=11&rft.spage=1727&rft.isbn=&rft.btitle=&rft.title=Chemosphere+%28Oxford%29&rft.issn=00456535&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00456535 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 4 tables, sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - CMSHAF N1 - SubjectsTermNotLitGenreText - air; Asia; central Taiwan; Chi-Chi earthquake 1999; concentration; earthquakes; Far East; instruments; particulate matter; pollution; sampling; suspended materials; Taichung Taiwan; Taiwan ER - TY - JOUR T1 - Evaluation of Nonisotopic DNA Hybridization Methods for Detection of the tdh Gene of Vibrio parahaemolyticus AN - 18389565; 5382049 AB - Production of the thermostable direct hemolysin (TDH) by Vibrio parahaemolyticus is associated with pathogenicity of the organism and is encoded by the tdh gene. The timely resolution of seafood-associated outbreaks requires rapid and accurate detection of pathogenic V. parahaemolyticus. The specificity of alkaline phosphatase- and digoxigenin-labeled tdh gene probes was evaluated against 61 strains of V. parahaemolyticus (including isolates from recent outbreaks involving oysters from the Pacific Northwest, Texas, and New York), 85 strains of other vibrios, and 7 strains of non-vibrio species from clinical and environmental sources. The probes were specific for detection of the V. parahaemolyticus tdh gene. JF - Journal of Food Protection AU - McCarthy, SA AU - DePaola, A AU - Cook, D W AU - Kaysner, CA AU - Hill, W E AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528, USA Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 1660 EP - 1664 VL - 63 IS - 12 SN - 0362-028X, 0362-028X KW - digoxigenin KW - outbreaks KW - tdh gene KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01116:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18389565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Rock+strength+determination+using+a+new+true+triaxial+loading+apparatus%2C+and+the+inadequacy+of+Mohr-type+failure+criteria&rft.au=Chang%2C+C%3BHaimson%2C+Bezalel+C&rft.aulast=Chang&rft.aufirst=C&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Bird nesting ecology in a forest defoliated by gypsy moths AN - 17839888; 4876958 AB - Acadian Flycatcher (Empidonax virescens, n = 55), Indigo Bunting (Passerina cyanea, n = 60), Eastern Towhee (Pipilo erythrophthalmus, n = 41), and Wood Thrush (Hylocichla mustelina, n = 62) nests were monitored during 1995-1996 in the eastern panhandle of West Virginia, at the Sleepy Creek Wildlife Management Area. The objective of this study was to relate the outcomes of bird nests to surrounding habitat characteristics in an area that experienced heavy tree mortality from prior defoliation by the gypsy moth (Lymantria dispar). Large (> 22.9 cm dbh) standing snags in the nest patch were not associated with nest failure for any of the four bird species. Very large diameter (> 38.1 cm dbh) live trees and snags and reduced canopy cover increased the chances of Brown-headed Cowbird (Molothrus ater) parasitism only for Indigo Buntings. Nest patches of all four species differed in vegetation characteristics from random plots in similar habitat, typically by having greater densities of species' preferred nesting substrate in the nest patch. Gypsy moth defoliation, which can result in an increase in snags and opened canopy, is not likely to be a devastating ecological event for shrub and sub-canopy nesting avian species, and can create more nesting habitat for many species that use a dense forest understory. JF - Wilson Bulletin AU - Bell, J L AU - Whitmore, R C AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, MS/P-1133, Morgantown, WV 26505-2888, USA, jbell@cdc.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 524 EP - 531 VL - 112 IS - 4 SN - 0043-5643, 0043-5643 KW - Gypsy Moth KW - Acadian flycatcher KW - Indigo bunting KW - Wood thrush KW - Eastern towhee KW - Lepidoptera KW - Aves KW - USA, West Virginia KW - Entomology Abstracts; Ecology Abstracts KW - Pest attack KW - Passerina cyanea KW - Hylocichla mustelina KW - Forests KW - Breeding KW - Empidonax virescens KW - Defoliation KW - Population levels KW - Pipilo erythrophthalmus KW - Lymantria dispar KW - D 04671:Birds KW - Z 05205:Populations & general ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17839888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wilson+Bulletin&rft.atitle=Bird+nesting+ecology+in+a+forest+defoliated+by+gypsy+moths&rft.au=Bell%2C+J+L%3BWhitmore%2C+R+C&rft.aulast=Bell&rft.aufirst=J&rft.date=2000-12-01&rft.volume=112&rft.issue=4&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=Wilson+Bulletin&rft.issn=00435643&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lymantria dispar; Empidonax virescens; Pipilo erythrophthalmus; Passerina cyanea; Hylocichla mustelina; Population levels; Breeding; Defoliation; Forests; Pest attack ER - TY - JOUR T1 - Characterization of Chloramphenicol and Florfenicol Resistance in Escherichia coli Associated with Bovine Diarrhea AN - 17839135; 4869779 AB - Florfenicol, a veterinary fluorinated analog of thiamphenicol, is approved for treatment of bovine respiratory pathogens in the United States. However, florfenicol resistance has recently emerged among veterinary Escherichia coli isolates incriminated in bovine diarrhea. The flo gene, which confers resistance to florfenicol and chloramphenicol, has previously been identified in Photobacterium piscicida and Salmonella enterica serovar Typhimurium DT104. The flo gene product is closely related to the CmlA protein identified in Pseudomonas aeruginosa. The cmlA gene confers nonenzymatic chloramphenicol resistance via an efflux mechanism. Forty-eight E. coli isolates recovered from calves with diarrhea, including 41 that were both chloramphenicol and florfenicol resistant, were assayed for the presence of both flo and cmlA genes. Forty-two of the 44 isolates for which florfenicol MICs were >=16 mu g/ml were positive via PCR for the flo gene. All E. coli isolates for which florfenicol MICs were =32 mu g/ml. Additionally, eight isolates were positive for both flo and cmlA, and both florfenicol and chloramphenicol MICs for these isolates were >=64 mu g/ml. DNA sequence analysis of the E. coli flo gene demonstrated 98% identity to the published GenBank sequences of both serovar Typhimurium flo sub(St) and P. piscicida pp-flo. The flo gene was identified on high-molecular-weight plasmids of approximately 225 kb among the majority of florfenicol-resistant E. coli isolates. However, not all of the florfenicol-resistant E. coli isolates tested contained the large flo-positive plasmids. This suggests that several of the E. coli isolates may possess a chromosomal flo gene. The E. coli flo gene specifies nonenzymatic cross-resistance to both florfenicol and chloramphenicol, and its presence among bovine E. coli isolates of diverse genetic backgrounds indicates a distribution much wider than previously thought. JF - Journal of Clinical Microbiology AU - White, D G AU - Hudson, C AU - Maurer, J J AU - Ayers, S AU - Zhao, S AU - Lee, MD AU - Bolton, L AU - Foley, T AU - Sherwood, J AD - Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, dwhite@cvm.fda.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 4593 EP - 4598 VL - 38 IS - 12 SN - 0095-1137, 0095-1137 KW - isolates KW - cattle KW - florfenicol KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Chloramphenicol KW - Diarrhea KW - Escherichia coli KW - Antibiotic resistance KW - A 01064:Microbial resistance KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17839135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Characterization+of+Chloramphenicol+and+Florfenicol+Resistance+in+Escherichia+coli+Associated+with+Bovine+Diarrhea&rft.au=White%2C+D+G%3BHudson%2C+C%3BMaurer%2C+J+J%3BAyers%2C+S%3BZhao%2C+S%3BLee%2C+MD%3BBolton%2C+L%3BFoley%2C+T%3BSherwood%2C+J&rft.aulast=White&rft.aufirst=D&rft.date=2000-12-01&rft.volume=38&rft.issue=12&rft.spage=4593&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Antibiotic resistance; Diarrhea; Chloramphenicol ER - TY - JOUR T1 - Developmental Neurotoxicity of Endocrine Disrupters: Focus on Estrogens AN - 17820789; 4856601 AB - A number of different environmental compounds are proposed to interact with the endocrine system (i.e., endocrine disrupters). Many of these have estrogenic effects in vitro and/or in vivo. Recent reviews have focused attention on the need for assessing the neurotoxicity of these compounds following developmental exposure. This attention comes in part from the literature on the effects of developmental exposure to exogenous estrogen on later behavioral and neuropathological alterations. A review of the ongoing neurobehavioral and neuropathological studies at the National Center for Toxicological Research on four such estrogen mimics (genistein, methoxychlor, nonylphenol, and ethinyl estradiol) is presented with results indicating that intake of a sodium solution is sensitive to these estrogen mimics. Developmental dietary exposure in male and female rats resulted in increased consumption of the sodium solution. Volume of the sexually dimorphic nucleus of the medial preoptic area was reduced by genistein, nonylphenol, and ethinyl estradiol exposure in males. The regulatory impact of these data and the directions for future research are discussed. JF - Neurotoxicology AU - Ferguson, SA AU - Scallet, A C AU - Flynn, K M AU - Meredith, J M AU - Schwetz, BA AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA, sferguson@nctr.fda.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 947 EP - 956 PB - Intox Press VL - 21 IS - 6 SN - 0161-813X, 0161-813X KW - rats KW - endocrine disruptors KW - ethinyl estradiol KW - genistein KW - methoxychlor KW - methoxyclor KW - nonphenol KW - nonyl phenol KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Estrogens KW - Reviews KW - Neurotoxicity KW - Steroid hormones KW - Endocrine system KW - Genistein KW - N3 11104:Mammals (except primates) KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17820789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Developmental+Neurotoxicity+of+Endocrine+Disrupters%3A+Focus+on+Estrogens&rft.au=Ferguson%2C+SA%3BScallet%2C+A+C%3BFlynn%2C+K+M%3BMeredith%2C+J+M%3BSchwetz%2C+BA&rft.aulast=Ferguson&rft.aufirst=SA&rft.date=2000-12-01&rft.volume=21&rft.issue=6&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neurotoxicity; Reviews; Estrogens; Endocrine system; Genistein; Steroid hormones ER - TY - JOUR T1 - The Determination of Phosphorus in Haemophilus influenzae Type b Conjugate Vaccines by Inductively Coupled Plasma-Atomic Emission Spectrometry AN - 17817904; 4858178 AB - This study describes a method for the determination of phosphorus in lyophilized Haemophilus influenzae type b conjugate vaccines by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). The concentration of polysaccharide is directly related to the concentration of phosphorus as measured in the laboratory. Phosphorus is present in the polyribosyl-ribitol phosphate (PRP) group of the Haemophilus influenzae type b conjugate vaccine. The repeating unit of PRP is 3-B-D ribose[1-1]ribitol-5-phosphate. Phosphorus in the final container is measured in mu g per dose. The amount of PRP is calculated from this and reported in mu g per dose. The Haemophilus influenzae type b conjugate vaccine was analyzed for phosphorus content within the range of 1.34 to 2.02 mu g phosphorus per ml. The relative difference of phosphorus concentrations determined by the ICP-AES method from the phosphorus concentrations determined by the traditional colorimetric molybdate method ranged from 2.2 to 10.6%. Phosphorus spike recovery for the vaccine ranged from 93 to 99% (1.93 plus or minus 0.13 mu g P/ml). The phosphorus determination of NIST SRM 3139 phosphorus spectrometric solution differed by 3.0% from the certified phosphorus value (10.00 mg P/ml). Copyright 2000 United States Government JF - Biologicals AU - Swartz, LA AU - Progar, J J AU - May, J C AD - Center for Biologics Evaluation and Research, United States Food and Drug Administration, Rockville, 20852, MD, U.S.A. Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 227 EP - 231 PB - Academic Press VL - 28 IS - 4 SN - 1045-1056, 1045-1056 KW - Haemophilus influenzae KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Medical and Pharmaceutical Biotechnology Abstracts KW - Phosphorus KW - Vaccines KW - Spectrometry KW - J 02834:Vaccination and immunization KW - W3 33365:Vaccines (other) KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17817904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=The+Determination+of+Phosphorus+in+Haemophilus+influenzae+Type+b+Conjugate+Vaccines+by+Inductively+Coupled+Plasma-Atomic+Emission+Spectrometry&rft.au=Swartz%2C+LA%3BProgar%2C+J+J%3BMay%2C+J+C&rft.aulast=Swartz&rft.aufirst=LA&rft.date=2000-12-01&rft.volume=28&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/10.1006%2Fbiol.2000.0261 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Haemophilus influenzae; Spectrometry; Vaccines; Phosphorus DO - http://dx.doi.org/10.1006/biol.2000.0261 ER - TY - JOUR T1 - Effects of Benzothiazole on the Xenobiotic Metabolizing Enzymes and Metabolism of Acetaminophen AN - 17782007; 4830660 AB - Benzothiazole (BT) is present in tobacco smoke and widely used for industrial and pharmaceutical purposes. In this study we have investigated the influence of BT on the activities of hepatic cytochrome P450 monooxygenases (P450s) and UDP-glucuronyltransferase (UDP-GT), sulphotransferase and glutathione-S-transferase (GST) in male Sprague-Dawley rats. We also examined if BT would change the metabolism and toxification of acetaminophen (AA) through modulation of metabolizing enzymes. Benzothiazole (1 mmol kg super(-1), p.o., 5 days) markedly increased the enzyme activities of P4501A1, 1A2, 2B1, 3A4, 2E1, UDP-GT and GST in liver. Pretreatment with BT significantly decreased the amount of total AA recovered in bile to 68.5% of controls, mainly as a consequence of reduced AA-glucuronide conjugate (35.3% of controls), whereas the AA-glutathione conjugate (AA-GS) was augmented to 1.6-fold. After pretreatment with BT, potentiation of the hepatotoxicity by AA (400 mg kg super(-1), i.p., 24 h) was observed by measuring serum alanine aminotransferase activities in ICR mice. These results indicate that: BT is a potent inducer of P450s and phase II metabolizing enzymes; and the increase of AA-GS conjugate and aggravation of AA hepatotoxicity by BT may be related to induction of P450s. JF - Journal of Applied Toxicology AU - Seo, Kyung Won AU - Park, M AU - Kim, Jun Gyou AU - Kim, Tae Wan AU - Kim, Hyo Jung AD - Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyunggu, Seoul 122-020, Korea Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 427 EP - 430 VL - 20 IS - 6 SN - 0260-437X, 0260-437X KW - rats KW - benzothiazole KW - cytochrome P450 KW - Toxicology Abstracts KW - Drug metabolism KW - Xenobiotics KW - Acetaminophen KW - X 24114:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17782007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Effects+of+Benzothiazole+on+the+Xenobiotic+Metabolizing+Enzymes+and+Metabolism+of+Acetaminophen&rft.au=Seo%2C+Kyung+Won%3BPark%2C+M%3BKim%2C+Jun+Gyou%3BKim%2C+Tae+Wan%3BKim%2C+Hyo+Jung&rft.aulast=Seo&rft.aufirst=Kyung&rft.date=2000-12-01&rft.volume=20&rft.issue=6&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acetaminophen; Drug metabolism; Xenobiotics ER - TY - JOUR T1 - Epidemiologic investigation of respiratory morbidity at a nylon flock plant AN - 17730550; 4803183 AB - Background: A cluster of biopsy-confirmed interstitial lung disease among workers at a nylon flock plant led to a request for National Institute for Occupational Safety and Health investigators to conduct a health hazard evaluation. Methods: Part of the overall evaluation, reported here, involved a cross-sectional medical survey of current employees. The survey consisted of a questionnaire, spirometry and diffusing capacity testing, and chest radiograph. Results: Workers assigned to production and maintenance jobs reported frequent eye and throat irritation, respiratory symptoms, and systemic symptoms (i.e., generalized aches and fevers). Most reported improvement when away from work. Frequent respiratory/systemic symptom prevalence was significantly associated with departmental category, with days and hours worked per week, and with working on a flocking range. Compared to asymptomatic workers, symptomatic workers had similar mean ratios of forced expiratory volume in one second to forced vital capacity, but lower mean percent of predicted values for both forced vital capacity and diffusing capacity. All acceptable chest radiographs were classified as category 0 for small opacities. Conclusions: Findings of this study, along with those from studies reported elsewhere, implicate occupational exposure to flock-associated dust as a significant respiratory health hazard at this plant. JF - American Journal of Industrial Medicine AU - Washko, R M AU - Day, B AU - Parker, JE AU - Castellan, R M AU - Kreiss, K AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, kxk2@cdc.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 628 EP - 638 VL - 38 IS - 6 SN - 0271-3586, 0271-3586 KW - man KW - nylon KW - respiratory tract diseases KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Dust KW - Morbidity KW - Respiratory tract diseases KW - Epidemiology KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17730550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Epidemiologic+investigation+of+respiratory+morbidity+at+a+nylon+flock+plant&rft.au=Washko%2C+R+M%3BDay%2C+B%3BParker%2C+JE%3BCastellan%2C+R+M%3BKreiss%2C+K&rft.aulast=Washko&rft.aufirst=R&rft.date=2000-12-01&rft.volume=38&rft.issue=6&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Morbidity; Occupational exposure; Dust; Epidemiology; Respiratory tract diseases ER - TY - JOUR T1 - Strategies and testing methods for identifying mutagenic risks. AN - 72477773; 11113464 AB - The evolution of testing strategies and methods for identification of mutagenic agents is discussed, beginning with the concern over potential health and population effects of chemical mutagens in the late 1940s that led to the development of regulatory guidelines for mutagenicity testing in the 1970s and 1980s. Efforts to achieve international harmonization of mutagenicity testing guidelines are summarized, and current issues and needs in the field are discussed, including the need for quantitative methods of mutagenic risk assessment, dose-response thresholds, indirect mechanisms of mutagenicity, and the predictivity of mutagenicity assays for carcinogenicity in vivo. Speculation is offered about the future of mutagenicity testing, including possible near-term changes in standard test batteries and the longer-term roles of expression profiling of damage-response genes, in vivo mutagenicity testing methods, and models that better account for differences in metabolism between humans and laboratory model systems. JF - Mutation research AU - MacGregor, J T AU - Casciano, D AU - Müller, L AD - FDA Center for Drug Evaluation and Research, 5600 Fishers Lane, Rockville, MD 20857, USA. macgregorj@cder.fda.gov Y1 - 2000/11/20/ PY - 2000 DA - 2000 Nov 20 SP - 3 EP - 20 VL - 455 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Mutagens KW - Index Medicus KW - Humans KW - Carcinogenicity Tests -- standards KW - Mutagenicity Tests -- standards KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72477773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Strategies+and+testing+methods+for+identifying+mutagenic+risks.&rft.au=MacGregor%2C+J+T%3BCasciano%2C+D%3BM%C3%BCller%2C+L&rft.aulast=MacGregor&rft.aufirst=J&rft.date=2000-11-20&rft.volume=455&rft.issue=1-2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90. AN - 72435983; 10961990 AB - The aryl hydrocarbon receptor (AhR) has been shown to interact with an immunophilin-like molecule known as AhR-interacting protein (AIP) and to enhance AhR function. We show here that AIP associates with AhR homologues from mouse and fish, which can bind ligands such as dioxin, but nonligand binding homologues from Caenorhabditis elegans or Drosophila do not bind to AIP. However, a minimal ligand-binding domain of the AhR is incapable of binding AIP. The binding of AIP to AhR in reticulocyte lysate shows several of the characteristics of an hsp90-dependent process, including sensitivity to geldanamycin and temperature and a requirement for ATP or nonhydrolyzable analogues. Purified AIP binds to the C terminus of hsp90, and mutation of a conserved basic residue in the tetratricopeptide repeats of AIP (K266A, analogous to K97A in protein phosphatase 5) abolishes binding to hsp90. Mutation of K266A in AIP reduces binding to AhR by 75-80%; the geldanamycin sensitivity of this complex shows that AhR stabilizes the AIP-hsp90-AhR complex. The alpha-helical C terminus of AIP, which is outside the tetratricopeptide repeat domain, is absolutely required for binding to AhR as shown by deletions of the C-terminal 5 amino acids or alanine-scanning mutagenesis, but it is not required for binding of AIP to hsp90. The data support a model where 1) AIP binds to both hsp90 and AhR; 2) hsp90 is required for AhR-AIP binding; and 3) the binding of AhR to AIP stabilizes the AIP-hsp90-AhR complex. JF - The Journal of biological chemistry AU - Bell, D R AU - Poland, A AD - Centers for Disease Control, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA. david.bell@nottingham.ac.uk Y1 - 2000/11/17/ PY - 2000 DA - 2000 Nov 17 SP - 36407 EP - 36414 VL - 275 IS - 46 SN - 0021-9258, 0021-9258 KW - Benzoquinones KW - 0 KW - Cell Extracts KW - HSP90 Heat-Shock Proteins KW - Intracellular Signaling Peptides and Proteins KW - Lactams, Macrocyclic KW - Nucleotides KW - Proteins KW - Quinones KW - Receptors, Aryl Hydrocarbon KW - Recombinant Proteins KW - aryl hydrocarbon receptor-interacting protein KW - Lysine KW - K3Z4F929H6 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Animals KW - Transcription, Genetic KW - Quinones -- pharmacology KW - Lysine -- genetics KW - Lysine -- metabolism KW - Reticulocytes -- drug effects KW - Sequence Alignment KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Reticulocytes -- metabolism KW - Nucleotides -- pharmacology KW - Protein Biosynthesis KW - Temperature KW - Reticulocytes -- cytology KW - Mice KW - Amino Acid Sequence KW - Precipitin Tests KW - Binding Sites KW - Protein Binding -- drug effects KW - Protein Structure, Tertiary KW - Mutation KW - Proteins -- chemistry KW - HSP90 Heat-Shock Proteins -- metabolism KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Proteins -- metabolism KW - Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72435983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Binding+of+aryl+hydrocarbon+receptor+%28AhR%29+to+AhR-interacting+protein.+The+role+of+hsp90.&rft.au=Bell%2C+D+R%3BPoland%2C+A&rft.aulast=Bell&rft.aufirst=D&rft.date=2000-11-17&rft.volume=275&rft.issue=46&rft.spage=36407&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-29 N1 - Date created - 2000-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - (13)C NMR and electron ionization mass spectrometric data-activity relationship model of estrogen receptor binding. AN - 72414795; 11076692 AB - Two Spectroscopic Data-Activity Relationship (SDAR) models based on (13)C nuclear magnetic resonance (NMR) and electron ionization mass spectra (EI MS) data were developed for 108 compounds whose relative binding affinities (RBA) to the estrogen receptor are known. The (13)C NMR and EI MS data were used as spectrometric digital fingerprints to reflect the electronic and structural characteristics of the compounds. Both SDAR models segregated the 108 compounds into 20 strong, 15 medium, and 73 weak relative binding classifications. The first SDAR model, based on (13)C NMR data alone, gave a leave-one-out (LOO) cross-validation of 75.0%. The second SDAR model, based on a composite of (13)C NMR and EI MS data, gave a LOO cross-validation of 82.4%. Many of the misidentifications from the cross-validations were between medium and weak classifications, where there were fewer specific spectrometric characteristics to identify the relationship of spectra to estrogen receptor binding. Real and predicted (13)C NMR chemical shifts were used to test the predictive behavior of both SDAR models. The ease of use and speed of SDAR modeling may facilitate their use with other toxicological endpoints. JF - Toxicology and applied pharmacology AU - Beger, R D AU - Freeman, J P AU - Lay, J O AU - Wilkes, J G AU - Miller, D W AD - Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arizona 72079, USA. rbeger@NCTR.FDA.GOV Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 17 EP - 25 VL - 169 IS - 1 SN - 0041-008X, 0041-008X KW - Carbon Radioisotopes KW - 0 KW - Estrogens, Non-Steroidal KW - Receptors, Estrogen KW - Index Medicus KW - Discriminant Analysis KW - Estrogens, Non-Steroidal -- chemistry KW - Estrogens, Non-Steroidal -- metabolism KW - Magnetic Resonance Spectroscopy -- methods KW - Quantitative Structure-Activity Relationship KW - Models, Molecular KW - Receptors, Estrogen -- chemistry KW - Receptors, Estrogen -- metabolism KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72414795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=%2813%29C+NMR+and+electron+ionization+mass+spectrometric+data-activity+relationship+model+of+estrogen+receptor+binding.&rft.au=Beger%2C+R+D%3BFreeman%2C+J+P%3BLay%2C+J+O%3BWilkes%2C+J+G%3BMiller%2C+D+W&rft.aulast=Beger&rft.aufirst=R&rft.date=2000-11-15&rft.volume=169&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - C NMR and Electron Ionization Mass Spectrometric Data-Activity Relationship Model of Estrogen Receptor Binding AN - 17724315; 4795943 AB - Two Spectroscopic Data-Activity Relationship (SDAR) models based on super(13)C nuclear magnetic resonance (NMR) and electron ionization mass spectra (EI MS) data were developed for 108 compounds whose relative binding affinities (RBA) to the estrogen receptor are known. The super(13)C NMR and EI MS data were used as spectrometric digital fingerprints to reflect the electronic and structural characteristics of the compounds. Both SDAR models segregated the 108 compounds into 20 strong, 15 medium, and 73 weak relative binding classifications. The first SDAR model, based on super(13)C NMR data alone, gave a leave-one-out (LOO) cross-validation of 75.0%. The second SDAR model, based on a composite of super(13)C NMR and EI MS data, gave a LOO cross-validation of 82.4%. Many of the misidentifications from the cross-validations were between medium and weak classifications, where there were fewer specific spectrometric characteristics to identify the relationship of spectra to estrogen receptor binding. Real and predicted super(13)C NMR chemical shifts were used to test the predictive behavior of both SDAR models. The ease of use and speed of SDAR modeling may facilitate their use with other toxicological endpoints. JF - Toxicology and Applied Pharmacology AU - Beger, R D AU - Freeman, J P AU - Lay, JO Jr AU - Wilkes, J G AU - Miller, D W AD - Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, 72079, Arizona, rbeger@NCTR.FDA.GOV Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 17 EP - 25 PB - Academic Press VL - 169 IS - 1 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - N.M.R. KW - Xenobiotics KW - Estrogen receptors KW - Models KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17724315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=C+NMR+and+Electron+Ionization+Mass+Spectrometric+Data-Activity+Relationship+Model+of+Estrogen+Receptor+Binding&rft.au=Beger%2C+R+D%3BFreeman%2C+J+P%3BLay%2C+JO+Jr%3BWilkes%2C+J+G%3BMiller%2C+D+W&rft.aulast=Beger&rft.aufirst=R&rft.date=2000-11-15&rft.volume=169&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1006%2Ftaap.2000.9043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - N.M.R.; Xenobiotics; Models; Estrogen receptors DO - http://dx.doi.org/10.1006/taap.2000.9043 ER - TY - CONF T1 - Characterization of tumor vaccines during product development AN - 17859023; 5104553 AB - The term tumor vaccines encompasses a wide variety of diverse agents capable of interacting with the immune system to produce local inflammation, delayed type hypersensitivity reaction and/or tumor regression and, hopefully, a therapeutic effect. These vaccines may be grouped into the following general areas: (1) Cell-based vaccines such as manipulated tumor cells, activated peripheral blood or bone marrow-derived lymphocytes, dendritic cells or other antigen presenting cells (APC) and gene-modified tumor cells or other cells engineered to express cytokines, growth factors or tumor antigens. (2) Antigen preparations, such as synthetic peptides, purified antigens and tumor cell lysates. (3) Viral and plasmid vectors expressing therapeutic genes. (4) Liposome containing antigen, peptides, plasmids encoding tumor antigens. While no tumor vaccine has been licensed by the FDA, numerous clinical trials are ongoing and some products have advanced to Phase III pivotal stages of development. However, as with many novel products, major regulatory and scientific issues associated with clinical use of tumor vaccines remain to be addressed. In this paper, we address issues associated with different types of tumor vaccines and provide recommendations for the characterization of these vaccines at various stages of development. JF - Vaccine AU - Razzaque, A AU - Dye, E AU - Puri, R K Y1 - 2000/11/08/ PY - 2000 DA - 2000 Nov 08 SP - 644 EP - 647 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 19 IS - 6 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Immunotherapy KW - Tumors KW - Reviews KW - Antigen (tumor-associated) KW - Cytokines KW - Growth factors KW - Antigen-presenting cells KW - Vaccines KW - F 06818:Cancer immunotherapy KW - W3 33350:Cancer vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17859023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Characterization+of+tumor+vaccines+during+product+development&rft.au=Razzaque%2C+A%3BDye%2C+E%3BPuri%2C+R+K&rft.aulast=Razzaque&rft.aufirst=A&rft.date=2000-11-08&rft.volume=19&rft.issue=6&rft.spage=644&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Genetic and immunologic characterization of a novel serotype 4, 15 strain of Neisseria meningitidis AN - 17692116; 4781749 AB - The porin proteins of Neisseria meningitidis are important components of outer membrane protein (OMP) vaccines. The class 3 porin gene, porB, of a novel serogroup B, serotype 4, 15 isolate from Chile (Ch501) was found to be VR1-4, VR2-15, VR3-15 and VR4-15 by porB variable region (VR) typing. Rabbit immunization studies using outer membrane vesicles revealed immunodominance of individual PorB (class 3) VR epitopes. The predominant anti-Ch501 PorB response was directed to the VR1 epitope. Anti-PorB VR1 mediated killing was suggested by the bactericidal activity of Ch501 anti-sera against a type 4 strain not expressing PorA or class 5 OMPs. Studies that examine the molecular epidemiology of individual porB VRs, and the immune responses to PorB epitopes, may contribute to the development of broadly protective group B meningococcal vaccines. JF - FEMS Immunology and Medical Microbiology AU - Bash, M C AU - Lynn, F AU - Concepcion, N F AU - Tappero, J W AU - Carlone, G M AU - Frasch, CE AD - Division of Bacterial, Allergenic and Parasitic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA, bash@cber.fda.gov Y1 - 2000/11/04/ PY - 2000 DA - 2000 Nov 04 SP - 169 EP - 176 PB - Elsevier VL - 29 IS - 3 SN - 0928-8244, 0928-8244 KW - isolates KW - Chile KW - porB gene KW - Microbiology Abstracts B: Bacteriology KW - Typing KW - Genotyping KW - Immune response KW - Neisseria meningitidis KW - Meningitis KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17692116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Immunology+and+Medical+Microbiology&rft.atitle=Genetic+and+immunologic+characterization+of+a+novel+serotype+4%2C+15+strain+of+Neisseria+meningitidis&rft.au=Bash%2C+M+C%3BLynn%2C+F%3BConcepcion%2C+N+F%3BTappero%2C+J+W%3BCarlone%2C+G+M%3BFrasch%2C+CE&rft.aulast=Bash&rft.aufirst=M&rft.date=2000-11-04&rft.volume=29&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=FEMS+Immunology+and+Medical+Microbiology&rft.issn=09288244&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neisseria meningitidis; Immune response; Meningitis; Typing; Genotyping ER - TY - JOUR T1 - Fewer symptoms occur in same-serotype recurrent streptococcal tonsillopharyngitis. AN - 85356554; pmid-11074833 AB - BACKGROUND: Most patients with acute rheumatic fever report no antecedent pharyngitis. OBJECTIVE: To determine the clinical and microbiological characteristics of recurrent group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis. DESIGN: Prospective randomized trial. SUBJECTS: Symptoms were recorded and throat cultures were obtained at 4 to 6, 18 to 21, and 32 to 35 days following the start of treatment. A subset of 60 patients with subsequent GABHS episodes occurring were evaluated for a 0.2-or greater log rise in either antistreptolysin O or anti-deoxyribonuclease B titer to confirm a bona fide recurrence. RESULTS: Sixteen (27%) of 60 patients had recurrent GABHS tonsillopharyngitis of the same serotype that occurred 21 days or longer following the onset of the initial GABHS infection and was associated with a 0.2- or greater log rise in either antistreptolysin O or anti-deoxyribonuclease B titer, indicating bona fide recurrent infection; these recurrences all occurred within 55 days. Fewer patients with recurrent GABHS pharyngitis of the same serotype had headache (P =.02), sore throat (P =.006), fever (P =. 008), pharyngeal erythema (P<.001), pharyngeal edema (P<.001), pharyngeal exudate (P =.04), and adenitis (P =.03) compared with the initial episode. Chills, stomachache, scarlatina, tonsillar enlargement, and palatal petechiae were similar for both episodes. CONCLUSIONS: Fewer symptoms occur during recurrent GABHS pharyngitis of the same serotype compared with the initial infection. These patients may be less likely to seek physician attention, yet their infections put them at risk for sequelae. JF - Archives of otolaryngology--head & neck surgery AU - Lee, L H AU - Ayoub, E AU - Pichichero, M E AD - Food and Drug Administration, Division of Vaccines and Related Product Applications, HFM 475, Suite 370N, 1401 Rockville Pike, Rockville, MD 20852, USA. Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1359 EP - 1362 VL - 126 IS - 11 SN - 0886-4470, 0886-4470 KW - National Library of Medicine KW - Severity of Illness Index KW - Prospective Studies KW - Humans KW - Serotyping KW - Child KW - Adolescent KW - Recurrence KW - Child, Preschool KW - Streptococcus pyogenes -- classification KW - Streptococcus agalactiae -- classification KW - Tonsillitis -- microbiology KW - Pharyngitis -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85356554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Fewer+symptoms+occur+in+same-serotype+recurrent+streptococcal+tonsillopharyngitis.&rft.au=Lee%2C+L+H%3BAyoub%2C+E%3BPichichero%2C+M+E&rft.aulast=Lee&rft.aufirst=L&rft.date=2000-11-01&rft.volume=126&rft.issue=11&rft.spage=1359&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Effect of silica inhalation on the pulmonary clearance of a bacterial pathogen in Fischer 344 rats. AN - 72606025; 11361057 AB - Silica inhalation predisposes workers to bacterial infection and impairments in pulmonary defense function. In this study, we evaluated the effect of pre-exposure to silica on lung defense mechanisms by use of a rat pulmonary Listeria monocytogenes infection model. Male Fischer 344 rats were exposed by inhalation to filtered air or silica (15 mg/m3 x 6 h/day x 5 days/wk). After 21 or 59 days of silica exposure, the rats were inoculated intratracheally with 5 x 10(3) L. monocytogenes. At 0 (noninfected controls), 3, and 7 days after infection, the left lungs were removed, homogenized, and the number of viable L. monocytogenes was counted after an overnight culture at 37 degrees C. Bronchoalveolar lavage (BAL) was performed on the right lungs. Alveolar macrophages (AM) were collected, and the AM production of chemiluminescence (CL), an index of reactive oxygen species generation, was measured. The number of lavagable neutrophils (PMNs) and acellular BAL lactate dehydrogenase (LDH) activity were determined as indices of inflammation and injury, respectively. Pre-exposure to silica for 59 days caused substantial increases in PMN number and LDH activity compared with the air controls, whereas silica inhalation for both 21 and 59 days significantly enhanced the pulmonary clearance of L. monocytogenes compared with air controls. Dramatic elevations were also observed in zymosan- and phorbol myristate acetate (PMA)-stimulated CL production by lung phagocytes recovered from rats pre-exposed to silica for 59 days. These results demonstrate that short-term exposure to inhaled silica particles activates lung phagocytes, as evidenced by increases in reactive oxygen species. This up-regulation in the production of antimicrobial oxidants is likely responsible for the enhancement in pulmonary clearance of L. monocytogenes observed with short-term silica inhalation. JF - Lung AU - Antonini, J M AU - Roberts, J R AU - Yang, H M AU - Barger, M W AU - Ramsey, D AU - Castranova, V AU - Ma, J Y AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. PY - 2000 SP - 341 EP - 350 VL - 178 IS - 6 SN - 0341-2040, 0341-2040 KW - Reactive Oxygen Species KW - 0 KW - Silicon Dioxide KW - 7631-86-9 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Analysis of Variance KW - Bronchoalveolar Lavage KW - Macrophages, Alveolar -- metabolism KW - Neutrophils -- metabolism KW - Rats KW - Rats, Inbred F344 KW - Luminescent Measurements KW - Colony Count, Microbial KW - Up-Regulation KW - Administration, Inhalation KW - L-Lactate Dehydrogenase -- metabolism KW - Male KW - Silicon Dioxide -- administration & dosage KW - Pneumonia, Bacterial -- microbiology KW - Listeriosis -- immunology KW - Pneumonia, Bacterial -- immunology KW - Pneumonia, Bacterial -- metabolism KW - Silicon Dioxide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72606025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung&rft.atitle=Effect+of+silica+inhalation+on+the+pulmonary+clearance+of+a+bacterial+pathogen+in+Fischer+344+rats.&rft.au=Antonini%2C+J+M%3BRoberts%2C+J+R%3BYang%2C+H+M%3BBarger%2C+M+W%3BRamsey%2C+D%3BCastranova%2C+V%3BMa%2C+J+Y&rft.aulast=Antonini&rft.aufirst=J&rft.date=2000-11-01&rft.volume=178&rft.issue=6&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Lung&rft.issn=03412040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suggestion of a cause-and-effect relationship among coal rank, airborne dust, and incidence of workers' pneumoconiosis. AN - 72518644; 11192209 JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Page, S J AU - Organiscak, J A AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PA 15236, USA. sep8@cdc.gov PY - 2000 SP - 785 EP - 787 VL - 61 IS - 6 SN - 1529-8663, 1529-8663 KW - Air Pollutants, Occupational KW - 0 KW - Coal KW - Dust KW - Index Medicus KW - Humans KW - Incidence KW - United States -- epidemiology KW - Coal -- adverse effects KW - Pneumoconiosis -- etiology KW - Pneumoconiosis -- epidemiology KW - Air Pollutants, Occupational -- adverse effects KW - Coal Mining KW - Dust -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72518644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Suggestion+of+a+cause-and-effect+relationship+among+coal+rank%2C+airborne+dust%2C+and+incidence+of+workers%27+pneumoconiosis.&rft.au=Page%2C+S+J%3BOrganiscak%2C+J+A&rft.aulast=Page&rft.aufirst=S&rft.date=2000-11-01&rft.volume=61&rft.issue=6&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A quantitative study of aromatic amine permeation through protective gloves using amine adsorptive pads. AN - 72518069; 11192217 AB - A quantitative study of aromatic amine permeation through a glove material using Permea-Tec aromatic amine pads, used for the detection of chemical breakthrough of protective clothing, was performed for aniline following the microwave extraction process and gas chromatographic analysis. Aniline exhibited >99% adsorption on the pads at a spiking level of 1.94 mg (1.9 microL). Aniline showed recoveries from 65 to 89% (RSD < or =5.6%) over the range 1.1-1.9 microL (1.12-1.94 mg) of aniline applied to pads. The modified ASTM F739 and direct permeability testing procedures were used to determine breakthrough times for five protective glove materials using aniline as a challenge chemical. Breakthrough times for six protective gloves were determined, ranging from 182 sec to 82 min. The quantitative concentration of aniline on the pads following permeation through the gloves also was determined, ranging from 0.53 to 0.55 mg/cm2 (1.79-1.88 mg/pad). JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Vo, E AU - Berardinelli, S P AU - Hall, R C AU - El Ayouby, N AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV 26505, USA. PY - 2000 SP - 837 EP - 841 VL - 61 IS - 6 SN - 1529-8663, 1529-8663 KW - Aniline Compounds KW - 0 KW - aniline KW - SIR7XX2F1K KW - Index Medicus KW - United States KW - Equipment Design KW - Chromatography, Gas KW - Humans KW - Adsorption KW - Calibration KW - Permeability KW - Gloves, Protective -- standards KW - Materials Testing -- methods KW - Aniline Compounds -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72518069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Experimental+study+on+the+stability+of+dam+foundation+in+consideration+of+the+effect+of+the+concrete+plug+treatments&rft.au=Nakashima%2C+S%3BKishida%2C+K%3BAdachi%2C+T%3BIzu%2C+Y&rft.aulast=Nakashima&rft.aufirst=S&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Producing 13C NMR, infrared absorption, and electron ionization mass spectrometric data models of the monodechlorination of chlorobenzenes, chlorophenols, and chloroanilines. AN - 72513668; 11128104 AB - We have developed four spectroscopic data-activity relationship (SDAR) models of monodechlorination of 32 chlorinated benzene compounds in anaerobic estuarine sediment. The SDAR models were based on combinations of 13C nuclear magnetic resonance (NMR), infrared absorption (IR), and electron ionization mass spectrometric (EI MS) data. The SDAR models segregated the 32 compounds into 17 readily monodechlorinated compounds and 15 not readily monodechlorinated compounds. The SDAR model based on 13C NMR, IR, and EI MS data gave a leave-one-out cross-validation of 93.8%. The SDAR model based on a composite of 13C NMR and IR data gave a leave-one-out cross-validation of 90.6%. The SDAR model based on a composite of IR and EI MS data gave a leave-one-out cross-validation of 84.4%. The SDAR model based on a composite of 13C NMR and EI MS data gave a leave-one-out cross-validation of 84.4%. These reliable SDAR models provide a rapid and simple way to predict whether a chlorinated benzene compound will readily go through monodechlorination. The FDA has filed a patent application on methods of using any combination of spectral data (NMR, MS, UV-vis, IR, and fluorescence, phosphorescence) to model a chemical, physical, or biological endpoint. JF - Journal of chemical information and computer sciences AU - Beger, R D AU - Freeman, J P AU - Lay, J O AU - Wilkes, J G AU - Miller, D W AD - Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. rbeger@NCTR.FDA.GOV PY - 2000 SP - 1449 EP - 1455 VL - 40 IS - 6 SN - 0095-2338, 0095-2338 KW - Carbon Isotopes KW - 0 KW - Hydrocarbons, Chlorinated KW - Water Pollutants, Chemical KW - Index Medicus KW - Spectrophotometry, Infrared KW - Models, Chemical KW - Mass Spectrometry -- methods KW - Hydrocarbons, Chlorinated -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72513668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+computer+sciences&rft.atitle=Producing+13C+NMR%2C+infrared+absorption%2C+and+electron+ionization+mass+spectrometric+data+models+of+the+monodechlorination+of+chlorobenzenes%2C+chlorophenols%2C+and+chloroanilines.&rft.au=Beger%2C+R+D%3BFreeman%2C+J+P%3BLay%2C+J+O%3BWilkes%2C+J+G%3BMiller%2C+D+W&rft.aulast=Beger&rft.aufirst=R&rft.date=2000-11-01&rft.volume=40&rft.issue=6&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+computer+sciences&rft.issn=00952338&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluating presence/absence of target microbes in microbiological tests. AN - 72502959; 11128148 AB - A typical qualitative microbiological method performance (collaborative) study gathers a data set of responses about a test for the presence or absence of a target microbe. We developed 2 models that estimate false-positive and false-negative rates. One model assumes a constant probability that the tests will indicate the target microbe is present for any positive concentration in the test portion. The other model assumes that this probability follows a logistic curve. Test results from several method performance studies illustrate these estimates. JF - Journal of AOAC International AU - Blodgett, R J AU - Hitchins, A D AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA. PY - 2000 SP - 1429 EP - 1433 VL - 83 IS - 6 SN - 1060-3271, 1060-3271 KW - Index Medicus KW - Dairy Products -- microbiology KW - Logistic Models KW - Algorithms KW - Models, Statistical KW - Meat -- microbiology KW - Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72502959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Evaluating+presence%2Fabsence+of+target+microbes+in+microbiological+tests.&rft.au=Blodgett%2C+R+J%3BHitchins%2C+A+D&rft.aulast=Blodgett&rft.aufirst=R&rft.date=2000-11-01&rft.volume=83&rft.issue=6&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Handling adverse event reports. AN - 72477129; 11111664 JF - Nursing AU - Rich, S AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md., USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 78 VL - 30 IS - 11 SN - 0360-4039, 0360-4039 KW - Nursing KW - United States KW - United States Food and Drug Administration KW - Humans KW - Equipment Failure KW - Equipment Safety KW - Databases, Factual KW - Adverse Drug Reaction Reporting Systems -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72477129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Handling+adverse+event+reports.&rft.au=Rich%2C+S&rft.aulast=Rich&rft.aufirst=S&rft.date=2000-11-01&rft.volume=30&rft.issue=11&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=03604039&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-18 N1 - Date created - 2000-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Progress report on the guidance for industry for statistical aspects of the design, analysis, and interpretation of chronic rodent carcinogenicity studies of pharmaceuticals. AN - 72439793; 11104389 AB - The U.S. Food and Drug Administration (FDA) is in the process of preparing a draft Guidance for Industry document on the statistical aspects of carcinogenicity studies of pharmaceuticals for public comment. The purpose of the document is to provide statistical guidance for the design of carcinogenicity experiments, methods of statistical analysis of study data, interpretation of study results, presentation of data and results in reports, and submission of electronic study data. This article covers the genesis of the guidance document and some statistical methods in study design, data analysis, and interpretation of results included in the draft FDA guidance document. JF - Journal of biopharmaceutical statistics AU - Lin, K K AD - Division of Biometrics 2, Office of Biostatistics, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 481 EP - 501 VL - 10 IS - 4 SN - 1054-3406, 1054-3406 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Reproducibility of Results KW - Humans KW - Guidelines as Topic KW - Rodentia KW - Research Design -- statistics & numerical data KW - Drug-Related Side Effects and Adverse Reactions KW - Data Interpretation, Statistical KW - Drug Industry -- statistics & numerical data KW - Carcinogenicity Tests -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72439793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Progress+report+on+the+guidance+for+industry+for+statistical+aspects+of+the+design%2C+analysis%2C+and+interpretation+of+chronic+rodent+carcinogenicity+studies+of+pharmaceuticals.&rft.au=Lin%2C+K+K&rft.aulast=Lin&rft.aufirst=K&rft.date=2000-11-01&rft.volume=10&rft.issue=4&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=10543406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Current status of food animal antidotes. AN - 72425400; 11084985 AB - The availability of antidotes in veterinary medicine has been an issue for more than a decade. Antidotes are available for food animals through extralabel use, regulatory discretion, and compounding. There is little economic incentive for pharmaceutical companies to pursue approval of antidotes and other drug products that have a small market. In addition, human food safety concerns must be addressed when approving antidotes for use in food animals. This article provides a brief history of antidote availability, current mechanisms for procuring food animal antidotes, and availability of specific antidotes for use in food animals. JF - The Veterinary clinics of North America. Food animal practice AU - Post, L O AU - Keller, W C AD - Division of Surveillance, Food and Drug Administration, Rockville, Maryland, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 445 EP - 53, vi VL - 16 IS - 3 SN - 0749-0720, 0749-0720 KW - Antidotes KW - 0 KW - Index Medicus KW - United States KW - Animals, Domestic KW - Food Contamination -- prevention & control KW - Animals KW - Humans KW - Animal Husbandry KW - Drug Approval KW - Antidotes -- supply & distribution KW - Antidotes -- therapeutic use KW - Veterinary Medicine KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Consumer Product Safety -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72425400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Veterinary+clinics+of+North+America.+Food+animal+practice&rft.atitle=Current+status+of+food+animal+antidotes.&rft.au=Post%2C+L+O%3BKeller%2C+W+C&rft.aulast=Post&rft.aufirst=L&rft.date=2000-11-01&rft.volume=16&rft.issue=3&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=The+Veterinary+clinics+of+North+America.+Food+animal+practice&rft.issn=07490720&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure potentials during cleaning, overhauling and repairing of aircraft lavatory tanks and hardware. AN - 72389951; 11062923 JF - Applied occupational and environmental hygiene AU - Burton, N C AU - McCleery, R E AD - Hazard Evaluation and Technical Assistance Branch of NIOSH, Cincinnati, Ohio 45226, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 803 EP - 808 VL - 15 IS - 11 SN - 1047-322X, 1047-322X KW - Index Medicus KW - Bacterial Infections KW - Ventilation KW - Humans KW - Hygiene KW - Disease Transmission, Infectious KW - Occupational Exposure KW - Toilet Facilities KW - Aircraft UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72389951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Exposure+potentials+during+cleaning%2C+overhauling+and+repairing+of+aircraft+lavatory+tanks+and+hardware.&rft.au=Burton%2C+N+C%3BMcCleery%2C+R+E&rft.aulast=Burton&rft.aufirst=N&rft.date=2000-11-01&rft.volume=15&rft.issue=11&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-05 N1 - Date created - 2000-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of micronuclei following exposure to methylene di-phenyl diisocyanate: potential genotoxic metabolites. AN - 72376228; 11053546 AB - Methylene di-phenyl diisocyanate (MDI) is used to make polyurethane products. The predominant occupational disease attributed to diisocyanates, including MDI, is asthma; however, the potential for genotoxicity has also been of concern. Diisocyanates are very reactive compounds that can undergo nonenzymatic hydrolysis to form methylenedianiline (MDA), or react under physiological conditions with primary amines to form ureas and/or with thiols to form labile thiol acid esters. MDA is a carcinogen in animals and a suspected carcinogen in humans. Brown Norway rats (BNR) were exposed to either 7 or 113 mg/m(3) MDI aerosol for 1 h/week x3 weeks and sacrificed 1 week later. Micronuclei (MN) formation was assessed from bone marrow polychromatic erythrocytes (PCE). A dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MN-PCEs) was noted. In vitro exposure of Chinese hamster lung fibroblasts (V79) to MDA or MDI-thiol conjugates, but not to MDI, significantly increased the frequency of MN. MDI-thiol conjugate-exposed cell cultures did not have detectable levels of MDA. A significant increase in the number of V79 cells in metaphase, as well as the number of cells with precipitants within both the cytoplasm and nuclei, were noted in MDI-glutathione-exposed cultures. The results of this study indicate that MDI aerosol exposure can cause MN formation through either the hydrolysis of MDI to MDA or possibly the formation of thiol conjugates. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zhong, B Z AU - Siegel, P D AD - Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 102 EP - 108 VL - 58 IS - 1 SN - 1096-6080, 1096-6080 KW - Aerosols KW - 0 KW - Aniline Compounds KW - Carcinogens KW - Isocyanates KW - Mutagens KW - 4,4'-diphenylmethane diisocyanate KW - 101-68-8 KW - Glutathione KW - GAN16C9B8O KW - 4,4'-diaminodiphenylmethane KW - GG5LL7OBZC KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Bone Marrow Cells -- drug effects KW - Animals KW - Fibroblasts -- drug effects KW - Cysteine -- metabolism KW - Dose-Response Relationship, Drug KW - Microsomes, Liver -- metabolism KW - Glutathione -- metabolism KW - Aniline Compounds -- toxicity KW - Rats, Inbred Strains KW - Rats KW - Rats, Sprague-Dawley KW - Inhalation Exposure KW - Microsomes, Liver -- drug effects KW - Bone Marrow Cells -- cytology KW - Cell Line KW - Cricetinae KW - Erythrocytes -- drug effects KW - Isocyanates -- administration & dosage KW - Micronucleus Tests KW - Isocyanates -- toxicity KW - Carcinogens -- metabolism KW - Carcinogens -- administration & dosage KW - Isocyanates -- metabolism KW - Mutagens -- metabolism KW - Erythrocytes -- cytology KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Mutagens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72376228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Induction+of+micronuclei+following+exposure+to+methylene+di-phenyl+diisocyanate%3A+potential+genotoxic+metabolites.&rft.au=Zhong%2C+B+Z%3BSiegel%2C+P+D&rft.aulast=Zhong&rft.aufirst=B&rft.date=2000-11-01&rft.volume=58&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Latex allergy in the workplace. AN - 72375695; 11053535 AB - While less than 1% of the general population is sensitized to latex, the U.S. Occupational Safety and Health Administration estimates that 8-12% of health-care workers are sensitized. The major source of workplace exposure is powdered natural rubber latex (NRL) gloves. NRL is harvested from HEVEA: brasiliensis trees and ammoniated to prevent coagulation resulting in the hydrolysis of the latex proteins. Prior to use in manufacturing, the latex is formulated by the addition of multiple chemicals. Thus, human exposure is to a mixture of residual chemicals and hydrolyzed latex peptides. Clinical manifestations include irritant contact dermatitis, allergic contact dermatitis (type IV), and type I immediate hypersensitivity response. Type I (IgE-mediated) NRL allergy includes contact urticaria, systemic urticaria, angioedema, rhinitis, conjunctivitis, bronchospasm, and anaphylaxis. Taking an accurate history, including questions on atopic status, food allergy, and possible reactions to latex devices makes diagnosis of type-I latex allergy possible. To confirm a diagnosis, either in vivo skin prick testing (SPT) or in vitro assays for latex-specific IgE are performed. While the SPT is regarded as a primary confirmatory test for IgE-mediated disease, the absence of a U.S. Food and Drug Administration-licensed HEVEA: brasiliensis latex extract has restricted its use in diagnosis. Serological tests have, therefore, become critically important as alternative diagnostic tests. Three manufacturers currently have FDA clearance for in vitro tests, to detect NRL-specific IgE. The commercially available assays may disagree on the antibody status of an individual serum, which may be due to the assay's detecting anti-NRL IgEs to different allergenic NRL proteins. Sensitized individuals produce specific IgE antibody to at least 10 potent HEVEA: allergens, Hev b 1-Hev b 10, each of which differs in its structure, size, and net charge. The relative content and ratios of Hevs in the final allergen preparation most probably could effect diagnostic accuracy. The Hev proteins have been cloned and expressed as recombinant proteins. Sequencing demonstrates both unique epitopes and sequences commonly found in other plant proteins. Sequence homology helps to explain the cross reactivity to a variety of foods experienced by latex allergic individuals. The development of recombinant allergens provides reagents that should improve the diagnostic accuracy of tests for latex allergy. Although clinical and exposure data have been gathered on the factors affecting response in latex-allergic individuals, less is known regarding the development of sensitization. Coupled with in vitro dermal penetration studies, murine models have been established to investigate the route of exposure in the development of latex sensitization. Time-course and dose-response studies have shown subcutaneous, intratracheal, or topical administrations of non-ammoniated latex proteins to induce IgE production. Both in vitro penetration and in vivo studies highlight the importance of skin condition in the development of latex allergy, with enhanced penetration and earlier onset of IgE production seen with experimentally abraded skin. The diagnosis of latex allergy is complicated by these variables, which in turn hinder the development of intervention strategies. Further epidemiological assessment is needed to more explicitly define the scope, trends, and demographics of latex allergy. Diagnostic accuracy can be improved through greater knowledge of proteins involved in the development of latex allergy, and better documentation of the presently available diagnostic tests. In vivo and in vitro models can elucidate mechanisms of sensitization and provide an understanding of the role of the exposure route in latex allergy-associated diseases. Together, these efforts can lead to intervention strategies for reducing latex allergy in the workplace. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Toraason, M AU - Sussman, G AU - Biagini, R AU - Meade, J AU - Beezhold, D AU - Germolec, D AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. mtorasson@cdc.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 5 EP - 14 VL - 58 IS - 1 SN - 1096-6080, 1096-6080 KW - Reagent Kits, Diagnostic KW - 0 KW - Index Medicus KW - Humans KW - Health Personnel KW - Disease Models, Animal KW - Prevalence KW - Latex Hypersensitivity -- etiology KW - Latex Hypersensitivity -- epidemiology KW - Latex Hypersensitivity -- prevention & control KW - Dermatitis, Allergic Contact -- epidemiology KW - Dermatitis, Occupational -- etiology KW - Dermatitis, Allergic Contact -- prevention & control KW - Dermatitis, Allergic Contact -- etiology KW - Dermatitis, Occupational -- prevention & control KW - Occupational Exposure -- adverse effects KW - Dermatitis, Occupational -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72375695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Latex+allergy+in+the+workplace.&rft.au=Toraason%2C+M%3BSussman%2C+G%3BBiagini%2C+R%3BMeade%2C+J%3BBeezhold%2C+D%3BGermolec%2C+D&rft.aulast=Toraason&rft.aufirst=M&rft.date=2000-11-01&rft.volume=58&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Subchronic silica exposure enhances respiratory defense mechanisms and the pulmonary clearance of Listeria monocytogenes in rats. AN - 72308387; 11015141 AB - Both Listeria monocytogenes infection and silica exposure have been shown to significantly alter immune responses. In this study, we evaluated the effect of preexposure to silica on lung defense mechanisms using a rat pulmonary L. monocytogenes infection model. Male Sprague-Dawley rats were instilled intratracheally with saline (vehicle control) or silica using either an acute treatment regimen (5 mg/kg; 3 days) or a subchronic treatment protocol (80 mg/kg; 35 days). At 3 or 35 days after silica instillation, the rats were inoculated intratracheally with either approximately 5000 or 500,000 L. monocytogenes. At 3, 5, and 7 days postinfection, the left lung was removed, homogenized, and cultured on brain heart infusion agar at 37 degrees C. The numbers of viable L. monocytogenes were counted after an overnight incubation. Bronchoalveolar lavage (BAL) was performed on the right lungs, and BAL cell differentials, acellular lactate dehydrogenase (LDH) activity and albumin content were determined. Alveolar macrophage (AM) chemiluminescence (CL) and phagocytosis were assessed as a measure of macrophage function. Lung-associated lymph nodes were removed, and lymphocytes were recovered and differentiated. Preexposure to silica significantly increased the pulmonary clearance of L. monocytogenes as compared to saline controls. Exposure to silica caused significant increases in BAL neutrophils, LDH and albumin, and lymph-nodal T cells and natural killer (NK) cells in infected and noninfected rats. CL and phagocytosis were also elevated in silica-treated rats. In summary, the results demonstrated that exposure of rats to silica enhanced pulmonary immune responses, as evidenced by increases in neutrophils, NK cells, T lymphocytes, and macrophage activation. These elevations in pulmonary immune response are likely responsible for the increase in pulmonary clearance of L. monocytogenes observed with preexposure to silica. JF - Inhalation toxicology AU - Antonini, J M AU - Yang, H M AU - Ma, J Y AU - Roberts, J R AU - Barger, M W AU - Butterworth, L AU - Charron, T G AU - Castranova, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. jga6@cdc.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1017 EP - 1036 VL - 12 IS - 11 SN - 0895-8378, 0895-8378 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Macrophages -- physiology KW - Cell Differentiation KW - Neutrophils -- physiology KW - Lymphocytes -- physiology KW - Male KW - Lung -- immunology KW - Silicon Dioxide -- adverse effects KW - Lung -- microbiology KW - Listeria monocytogenes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72308387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Subchronic+silica+exposure+enhances+respiratory+defense+mechanisms+and+the+pulmonary+clearance+of+Listeria+monocytogenes+in+rats.&rft.au=Antonini%2C+J+M%3BYang%2C+H+M%3BMa%2C+J+Y%3BRoberts%2C+J+R%3BBarger%2C+M+W%3BButterworth%2C+L%3BCharron%2C+T+G%3BCastranova%2C+V&rft.aulast=Antonini&rft.aufirst=J&rft.date=2000-11-01&rft.volume=12&rft.issue=11&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=08958378&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy of agents for pharmacologic conversion of atrial fibrillation and subsequent maintenance of sinus rhythm: a meta-analysis of clinical trials. AN - 71280944; 11093570 AB - Physicians have little evidentiary guidance for pharmacologic agent selection for atrial fibrillation (AF). To assess antiarrhythmic agent efficacy for AF conversion and subsequent maintenance of sinus rhythm (MSR). We searched the clinical trial database of the Cochrane Collaboration and MEDLINE encompassing literature from 1948 to May 1998. We selected 36 (28%) articles eligible as randomized trials of nonpostoperative AF conversion or MSR in adults. Study quality; rates of conversion, MSR, and adverse events were extracted. Compared with control treatment (placebo, verapamil, diltiazem, or digoxin), the odds ratio (OR) for conversion was greatest for ibutilide/dofetilide (OR=29.1; 95% confidence interval [CI], 9.8-86.1) and flecainide (OR=24.7; 95% CI, 9.0-68.3). Less strong but conclusive evidence existed for propafenone (OR=4.6; 95% CI, 2.6-8.2). Quinidine (OR=2.9; 95% CI, 1.2-7.0) had moderate evidence of efficacy for conversion. Disopyramide (OR=7.0; 95% CI, 0.3-153.0) and amiodarone (OR=5.7; 95% CI, 1.0-33.4) had suggestive evidence of efficacy. Sotalol (OR=0.4; 95% CI, 0.0-3.0) had suggestive evidence of negative efficacy. For MSR, strong evidence of efficacy existed for quinidine (OR=4.1; 95% CI, 2.5-6.7), disopyramide (OR=3.4; CI, 1.6-7.1), flecainide (OR=3.1; 95% CI, 1.5-6.2), propafenone (OR=3.7; 95% CI, 2.4-5.7), and sotalol (OR=7.1; 95% CI, 3.8-13.4). The only amiodarone data, from comparison with disopyramide, provided moderate evidence of efficacy for MSR. No trial evaluated procainamide. Direct agent comparisons and adverse event data were limited. Although multiple antiarrhythmic agents had strong evidence of efficacy compared with control treatment for MSR, ibutilide/dofetilide and flecainide had particularly strong evidence of efficacy compared with control treatment for AF conversion. There is sparse and inconclusive evidence on direct agent comparisons and adverse event rates. Obtaining information regarding these relative efficacies should be a research priority. JF - The Journal of family practice AU - Miller, M R AU - McNamara, R L AU - Segal, J B AU - Kim, N AU - Robinson, K A AU - Goodman, S N AU - Powe, N R AU - Bass, E B AD - Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. mmiller@ahrq.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1033 EP - 1046 VL - 49 IS - 11 SN - 0094-3509, 0094-3509 KW - Anti-Arrhythmia Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Evidence-Based Medicine KW - Humans KW - Aged KW - Middle Aged KW - Atrial Fibrillation -- drug therapy KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71280944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+family+practice&rft.atitle=Efficacy+of+agents+for+pharmacologic+conversion+of+atrial+fibrillation+and+subsequent+maintenance+of+sinus+rhythm%3A+a+meta-analysis+of+clinical+trials.&rft.au=Miller%2C+M+R%3BMcNamara%2C+R+L%3BSegal%2C+J+B%3BKim%2C+N%3BRobinson%2C+K+A%3BGoodman%2C+S+N%3BPowe%2C+N+R%3BBass%2C+E+B&rft.aulast=Miller&rft.aufirst=M&rft.date=2000-11-01&rft.volume=49&rft.issue=11&rft.spage=1033&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+family+practice&rft.issn=00943509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-08 N1 - Date created - 2000-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 2001 Jul-Aug;135(1):13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Improving Substance Abuse Treatment: The National Treatment Plan Initiative. Changing the Conversation. AN - 62347513; ED450296 AB - This report is the result of five expert panels and six regional public hearings around the country that focused on key persistent issues that have characterized discussions of substance abuse over the years: closing the treatment gap; reducing stigma and changing attitudes; improving and strengthening treatment systems; connecting services and research; and addressing workforce issues. Of particular interest is the Report of Panel V: Addressing Workforce Issues. Panel V identified three types of current workforce issues: education and training; credentialing; and supply, demand, and distribution. The objective of professionals to guarantee universal delivery of optimum standards of care, together with the recent connection between provider reimbursement and education levels, calls for a formal strategy and defines standards for educating and training substance abuse staff. The field also needs a cohesive and unified approach to counseling. Anecdotal evidence of staff shortages exists. The recommendations offered for alleviating these problems fall into three categories: those that address the need for a Federal agency, with responsibility for workforce-related issues such as education and development; those that seek to strengthen the workforce infrastructure in the substance abuse treatment system; and those that require implementation at a field and/or program level. (MKA) Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 308 PB - U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment. KW - ERIC, Resources in Education (RIE) KW - Substance Abuse KW - Counselor Training KW - Professional Training KW - Labor Force KW - Drug Education KW - Certification KW - Outcomes of Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62347513?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Healthy Children Are Ready To Learn: Promoting Health Insurance for Your Students. A Step-by-Step Guide for School Districts. AN - 62257546; ED461421 AB - Health problems impede the academic performance of many children. Schools are in a unique position to help their state's Medicaid and children's health insurance programs connect with parents who lack health insurance for their children. This guide provides suggestions for identifying eligible children, informing parents of free or low-cost insurance programs, and referring parents to their state's insurance program. Designed to help school districts participate in the outreach effort, the guide offers plans for several levels of involvement, from supporting the outreach efforts of others to conducting their own campaign. Part 1 of the guide outlines how schools can make health insurance available to students through: (1) distributing information about health insurance for children and adolescents; (2) identifying children who need health insurance; and (3) partnering with other agencies to secure health insurance for students. Part 2 lists resources for finding more information on developing health insurance outreach programs, including state contacts for Medicaid and state children's health insurance programs. Part 3 of the guide contains numerous tools, such as sample letters, tips on implementation, and prototype documents to support a district's selected outreach approach. (KB) Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 67 PB - Health Care Financing Administration, 7500 Security Blvd., Baltimore, MD 21244-1850 (HCFA Pub. No. 02196). KW - Childrens Health Insurance Program KW - Medicaid KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Practitioners KW - Program Descriptions KW - Outreach Programs KW - Health Insurance KW - Family School Relationship KW - Program Implementation KW - Enrollment KW - Child Health KW - Agency Cooperation KW - Elementary Secondary Education KW - Children KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62257546?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For related document on health insurance for child N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Ready, Set, Learn: Promoting Health Insurance for Children. A Guide for Schools. AN - 62253322; ED461422 AB - Health problems impede the academic performance of 12 percent of students. Schools are in a unique position to help their state's Medicaid and children's health insurance programs connect with parents who lack health insurance for their children. This booklet provides suggestions to help school staff identify, inform, and help to enroll families who need health insurance. The booklet presents information on the following outreach activities for schools: (1) making sure parents have materials on children's health insurance; (2) telling parents that free or low-cost health insurance is available for their children (includes tips for talking with parents); (3) distributing information at parent functions or sending it home; (4) identifying children who may lack insurance and passing along the names, focusing on the use of emergency contact cards; and (5) hosting outreach workers or application assistants from a partner organization. The booklet also describes creative, proactive strategies taken in four school districts to insure children in their schools and delineates suggestions for keeping track of the school's outreach activities. (KB) Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 16 PB - Health Care Financing Administration, 7500 Security Blvd., Baltimore, MD 21244-1850 (HCFA Pub. No. 02196). KW - Childrens Health Insurance Program KW - Medicaid KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Practitioners KW - Program Descriptions KW - Outreach Programs KW - Health Insurance KW - Family School Relationship KW - Child Advocacy KW - Enrollment KW - Child Health KW - Agency Cooperation KW - Program Evaluation KW - Children UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62253322?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For related document on health insurance for child N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Healthy people, 2010 AN - 59860473; 2003-1100010 AB - Describes 10-year national public health goals, divided into 467 objectives in 28 focus areas; includes extensive statistical data; US. V. 1, Understanding and improving health, Objectives for improving health (Part A: Focus areas 1-14); v. 2, Objectives for improving health (Part B: Focus Areas 15-28), Appendices. Also available on CD-ROM and on the Internet. JF - United States Department of Health and Human Services, November 2000. 2v. Y1 - 2000/11// PY - 2000 DA - November 2000 PB - United States Department of Health and Human Services KW - United States -- Health conditions -- Statistics KW - Public health -- United States KW - Medicine, Preventive -- United States KW - United States -- Health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59860473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Healthy+people%2C+2010&rft.title=Healthy+people%2C+2010&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services pa U.S. $70; elsewhere $87.50 N1 - Document feature - bibl(s), chart(s), index(es), map(s), table(s) N1 - SuppNotes - 2d ed. 2v N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Glass eels from Hainam Island and Guangdong Province, southern China AN - 20722508; 6912643 AB - A total of 31 anguillid glass eels were collected by fishermen along the east coast of Hainan Island and along the northeast coast of the Guangdong Province in southern China in January 1996. The glass eels were identified as six Anguilla japonica and 26 A. marmorata based on morphological characters (Tabeta et al. 1976). The A. japonica glass eels that were collected at the Guangdong Province, town of Tangwei, ranged from 51.0 to 57.0 mm in total length (TL). This is one of the southern most distribution records of A. japonica glass eels. The A. marmorata glass eels that were collected on Hainan Island and at Guangdong Province, ranged from 45.0 to 52.0 mm TL. These specimens all had early stages of pigmentation (VA-VIA2). The ages at recruitment of the A. japonica glass eels examined ranged from 145 to 209 (178.0 plus or minus 23 d; mean plus or minus SD). The duration of the leptocephalus, metamorphosing leptocephalus and glass eel stages in seawater were 144.3 plus or minus 23 d, 21 plus or minus 5 d and 17 plus or minus 9 d, respectively. Ages at recruitment of the A. marmorata glass eels examined ranged from 168 to 230 (189.5 plus or minus 21 d). The duration of the leptocephalus, metamorphosing leptocephalus and glass eel stages in seawater were 137.5 plus or minus 15 d, 25 plus or minus 3 d and 21 plus or minus 8 d, respectively. The hatching dates of both species were estimated to be from May to August. The duration of leptocephalus and glass eel stages in seawater of these species were relatively longer than indicated by data from previous studies on glass eel recruitment in Taiwan and Japan. The surface circulation in the South China Sea is much more variable than the steady northward flow of the Kuroshio Current and may result in a longer transport time to reach the south coast of China than to reach Japan. JF - Abstracts of papers presented at the 3rd East Asian Symposium on Eel Research. Sustainability of Resources and Aquaculture of Eels. Taiwan Fisheries Research Institute, November 16-18, 2000, Keelung, Taiwan. AU - Osame Tabeta AU - Setiawan, I E AU - Mochioka, Noritaka Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1 EP - 32 KW - Sustainability Science Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Anguilla marmorata KW - Age KW - Age at recruitment KW - distribution records KW - Seawater KW - Population dynamics KW - Aquaculture KW - Fish larvae KW - ISEW, China, People's Rep., Guangdong Prov. KW - Islands KW - Transportation KW - ISEW, China, People's Rep., Hainan Prov., Hainan I. KW - Water currents KW - recruitment KW - sustainability KW - Marine KW - Pigmentation KW - surface circulation KW - hatching KW - Developmental stages KW - Currents KW - Coastal zone KW - ISEW, Taiwan KW - ISEW, China, People's Rep., Guangdong Province KW - ISEW, South China Sea KW - towns KW - Anguilla japonica KW - INW, Donghai Sea, Kuroshio Current KW - ISEW, Taiwan, Keelung KW - Size distribution KW - M3 1010:Issues in Sustainable Development KW - Q1 08442:Population dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Sustainability+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Osame+Tabeta%3BSetiawan%2C+I+E%3BMochioka%2C+Noritaka&rft.aulast=Osame+Tabeta&rft.aufirst=&rft.date=2000-11-01&rft.volume=&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=Glass+eels+from+Hainam+Island+and+Guangdong+Province%2C+southern+China&rft.title=Glass+eels+from+Hainam+Island+and+Guangdong+Province%2C+southern+China&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Physical medium: Printed matter; Summary only., Presumably published in 2001 N1 - Last updated - 2014-05-07 ER - TY - RPRT T1 - Healthy People 2010. Volume 2: Objectives for Improving Health (Part B: Focus Areas 15-28); Appendices AN - 18162866; 4831064 AB - Healthy People 2010, Volume II; Healthy People 2010: Objectives for Improving Health (Part B); Injury and Violence Prevention; Maternal, Infant, Child, and Adolescent Deaths; Medical Product Safety; Mental health and mental Disorders; Nutrition and Overweight; Occupational Safety and Health; Oral Health; Physical Activity and Fitness; Public Health Infrastructure; Respiratory Diseases; Sexually Transmitted Diseases; Substance Abuse; Tobacco Use; Vision and Hearing; Appendices; Healthy People 2010, Volume 1; Message from the Secretary; Foreword; Reader's Guide; Healthy People 2010: Understanding and Improving Health; Healthy People 2010: Objectives for Improving Health (Part A); Access to Quality Health Services; Arthritis, Osteoporosis, and Chronic Back Conditions; Cancer; Chronic Kidney Disease; Diabetes; Disability and Secondary Conditions; Education and Community-Based Programs; Health Care Setting; Community Setting and Select Populations; Environmental Health; Family Planning; Food Safety; Health Communication; Heart Disease and Stroke; HIV; Immunization and Infectious Diseases; Index. Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 672 KW - Physical Education Index KW - PB2001101845 KW - Health KW - Diseases KW - Nutrition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18162866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Physical+Education+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-11-01&rft.volume=&rft.issue=&rft.spage=672&rft.isbn=0160504996&rft.btitle=Healthy+People+2010.+Volume+2%3A+Objectives+for+Improving+Health+%28Part+B%3A+Focus+Areas+15-28%29%3B+Appendices&rft.title=Healthy+People+2010.+Volume+2%3A+Objectives+for+Improving+Health+%28Part+B%3A+Focus+Areas+15-28%29%3B+Appendices&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - SuppNotes - Available from NTIS: 1-800-553-NTIS (USA); (703)605-6000 (other countries); fax at (703)605-6900; orders[at]ntis.fedworld.gov. NTIS Prices: PC A99/MF A06 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Roof monitoring helps prevent injuries in stone mines AN - 17864180; 5110216 AB - From 1990 to 1996, 16 states reported 92 injuries from falls of roof, rib or face in the more than 90 underground stone mines in the United States. Missouri, Pennsylvania and Kentucky accounted for 48% of the total number of injuries. Of this total, 11 miners were killed. Of the 11 fatalities, 10, or 91%, were associated with unrecognized loose or failed rock within the roof beam. Additionally, unrecognized roof beam failures resulted in a majority of the falls of ground injuries occurring in underground US stone mines from 1990 to 1996. This number is not large in magnitude. But a work force of fewer than 2,000 miners makes for a high fatal-accident rate. JF - Mining Engineering AU - Iannacchione, A T AU - Prosser, L J AU - Grau, R AU - Oyler, D C AU - Dolinar AU - Marshall, TE AU - Compton, C S AD - US National Institute for Occupational Safety and Health, Pittsburgh Research Center, Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 32 EP - 37 VL - 52 IS - 11 SN - 0026-5187, 0026-5187 KW - USA, Kentucky KW - USA, Missouri KW - USA, Pennsylvania KW - falls KW - Health & Safety Science Abstracts KW - Mortality KW - Accidents KW - Injuries KW - Occupational safety KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17864180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Roof+monitoring+helps+prevent+injuries+in+stone+mines&rft.au=Iannacchione%2C+A+T%3BProsser%2C+L+J%3BGrau%2C+R%3BOyler%2C+D+C%3BDolinar%3BMarshall%2C+TE%3BCompton%2C+C+S&rft.aulast=Iannacchione&rft.aufirst=A&rft.date=2000-11-01&rft.volume=52&rft.issue=11&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; Injuries; Mortality; Accidents; Mining ER - TY - JOUR T1 - Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes AN - 17765064; 4820670 AB - Pronounced glutamic acid uptake was observed after only 15 min with glutamate concentrations of 60 nmol/mg protein when astrocytes were incubated with 1 mM glutamic acid. The uptake increased with time to a steady-state glutamate level of above 160 nmol/mg protein by 45 min. The uptake was energy dependent. Reduced temperature (0 degree C) and ouabain (100 mu M) inhibited uptake by 86.7% (P < 0.001; n = 18) and 84.4% (P < 0.001; n = 18), respectively, when compared with controls. After exposure of astrocytes to glutamate (1 mM) in the incubation medium, in the presence of domoic acid (10 and 100 mu M) at 5 and 60 min, domoic acid (10 mu M) elevated glutamate uptake by 64.0% (P < 0.05; n = 34) at 5 min but decreased glutamate uptake by 47.8% (P < 0.01; n = 19) at 60 min compared with controls. A higher dose of domoic acid (100 mu M) decreased glutamate uptake by 49.6% (P < 0.01; n = 20) and 61.3% (P < 0.001; n = 20) at 5 and 60 min, respectively, compared with controls. This study suggests that domoic acid may induce neurotoxicity because of the failure of astrocytes to remove extracellular glutamate. This may contribute to excitotoxic injury. JF - Food and Chemical Toxicology AU - Ross, IA AU - Johnson, W AU - Sapienza, P P AU - Kim, C S AD - Division of Toxicological Research (HFS-506), Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA, CSK@vm.cfsan.fda.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1005 EP - 1011 VL - 38 IS - 11 SN - 0278-6915, 0278-6915 KW - rats KW - Toxicology Abstracts KW - Astrocytes KW - Domoic acid KW - Neurotoxicity KW - Glutamic acid KW - Food contamination KW - Toxins KW - X 24120:Food, additives & contaminants KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17765064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+the+seafood+toxin+domoic+acid+on+glutamate+uptake+by+rat+astrocytes&rft.au=Ross%2C+IA%3BJohnson%2C+W%3BSapienza%2C+P+P%3BKim%2C+C+S&rft.aulast=Ross&rft.aufirst=IA&rft.date=2000-11-01&rft.volume=38&rft.issue=11&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Domoic acid; Glutamic acid; Astrocytes; Toxins; Neurotoxicity; Food contamination ER - TY - JOUR T1 - Traumatic Injury Among Drywall Installers, 1992 to 1995 AN - 17744045; 4805123 AB - This study examined the traumatic-injury characteristics associated with one of the high-risk occupations in the construction industry--drywall installers--through an analysis of the traumatic-injury data obtained from the Bureau of Labor Statistics. An additional objective was to demonstrate a feasible and economic approach to identify risk factors associated with a specific occupation by using an existing database. An analysis of nonfatal traumatic injuries with days away from work among wage-and-salary drywall installers was performed for 1992 through 1995 using the Occupational Injury and Illness Survey conducted by the Bureau of Labor Statistics. Results from this study indicate that drywall installers are at a high risk of overexertion and falls to a lower level. More than 40% of the injured drywall installers suffered sprains, strains, and/or tears. The most frequently injured body part was the trunk. More than one-third of the trunk injuries occurred while handling solid building materials, mainly drywall. In addition, the database analysis used in this study is valid in identifying overall risk factors for specific occupations. JF - Journal of Occupational and Environmental Medicine AU - Chiou, S S AU - Pan, C S AU - Keane, P AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd. MS- P119, Morgantown, WV 26505, USA, schiou@cdc.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1101 EP - 1108 VL - 42 IS - 11 SN - 1076-2752, 1076-2752 KW - drywall installers KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - Injuries KW - Occupational safety KW - Hazards KW - Accidents KW - Construction industry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17744045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Traumatic+Injury+Among+Drywall+Installers%2C+1992+to+1995&rft.au=Chiou%2C+S+S%3BPan%2C+C+S%3BKeane%2C+P&rft.aulast=Chiou&rft.aufirst=S&rft.date=2000-11-01&rft.volume=42&rft.issue=11&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Accidents; Injuries; Construction industry; Occupational safety; Hazards; Risk assessment ER - TY - JOUR T1 - Controlled Flight into Terrain Accidents Among Commuter and Air Taxi Operators in Alaska AN - 17741579; 4808362 AB - Between 1990 and 1998, aviation accidents in Alaska caused 100 occupational pilot deaths (equivalent to 430/100,000 pilots/year, approximately 86 times the overall U.S. worker fatality rate). Although Alaskan geography and climate increase aviation risks, many accidents were attributed to pilot error. While most accidents occurred during takeoff/landing, most fatalities resulted from Controlled Flight Into Terrain (CFIT). The purpose of this study was to examine risk factors for CFIT. Using National Transportation Safety Board airplane accident data we identified CFIT from flight phase and event description fields, and calculated odds ratios for CFIT/non-CFIT accidents for visual conditions, aircraft features, and pilot experience. Between 1991 and 1998, 351 single aircraft commuter and air taxi accidents occurred in Alaska; 59 (17%) were CFIT. Of 140 total fatalities, 82 (59%) occurred in 30 CFIT accidents. There was a twelve-fold risk for death in CFIT vs. non-CFIT accidents (OR = 12.42, 95% CI = 8.19-18.88). Accidents while flying Visual Flight Rules (VFR) into poor visibility were more likely CFIT than non-CFIT (Odds ratio = 46.06, Confidence Interval = 19.32-112.46), and caused 37% of all deaths. Additionally, flights in Instrument Meteorological Conditions (IMC) were 47 times more likely to be CFIT than non-CFIT. No risk for CFIT was shown for flight hours, number of engines, passenger presence, or pilot age. All CFIT were attributed to pilot error, often for continuing VFR into poor visibility. CFIT caused most aviation deaths. Further research into human factors contributing to CFIT is needed. Implementation of global- positioning, ground-proximity/avoidance technology, might reduce CFIT incidence. JF - Aviation, Space and Environmental Medicine AU - Thomas, T K AU - Bensyl, D M AU - Manwaring, J C AU - Conway, G A AD - CDC/NIOSH, 4230 University Drive #310, Anchorage, AK 99508, USA, Dbensyl@cdc.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1098 EP - 1103 VL - 71 IS - 11 SN - 0095-6562, 0095-6562 KW - USA, Alaska KW - crew safety KW - pilots KW - Health & Safety Science Abstracts KW - Mortality KW - Accidents KW - Aircraft KW - Injuries KW - Occupational safety KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17741579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space+and+Environmental+Medicine&rft.atitle=Controlled+Flight+into+Terrain+Accidents+Among+Commuter+and+Air+Taxi+Operators+in+Alaska&rft.au=Thomas%2C+T+K%3BBensyl%2C+D+M%3BManwaring%2C+J+C%3BConway%2C+G+A&rft.aulast=Thomas&rft.aufirst=T&rft.date=2000-11-01&rft.volume=71&rft.issue=11&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Accidents; Injuries; Mortality; Aircraft; Occupational safety ER - TY - JOUR T1 - The NIOSH/FAA working women's health study: Evaluation of the cosmic-radiation exposures of flight attendants AN - 17732322; 4798542 AB - Air crew are exposed to elevated levels of cosmic ionizing radiation of galactic and solar origin and are among the more highly exposed occupational groups to ionizing radiation in the United States. Depending on flight route patterns, the annual dose may range from 0.2 to 5 mSv. By comparison, the average annual radiation dose equivalent of occupationally exposed adults in the United States is estimated to be 1.1 mSv. Cosmic-radiation dose depends primarily on altitude and geomagnetic latitude and to a lesser degree on solar activity. Although the International Commission on Radiological Protection has recommended that air crew exposures to natural radiation in-flight be treated as occupational exposures, United States flight crew exposures to natural cosmic radiation are not regulated or typically monitored. There are approximately 148,000 air crew (flight deck crew and flight attendants) in the United States. JF - Health Physics AU - Waters, M AU - Bloom, T F AU - Grajewski, B AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway R-14, Cincinnati, OH 45226-1998, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 553 EP - 559 VL - 79 IS - 5 SN - 0017-9078, 0017-9078 KW - flight attendants KW - crew safety KW - Pollution Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Aircraft KW - Dose-response effects KW - Occupational exposure KW - Cosmic radiation KW - R2 23080:Industrial and labor KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17732322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=The+NIOSH%2FFAA+working+women%27s+health+study%3A+Evaluation+of+the+cosmic-radiation+exposures+of+flight+attendants&rft.au=Waters%2C+M%3BBloom%2C+T+F%3BGrajewski%2C+B&rft.aulast=Waters&rft.aufirst=M&rft.date=2000-11-01&rft.volume=79&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Cosmic radiation; Aircraft; Dose-response effects ER - TY - JOUR T1 - Dietary Genistein Inactivates Rat Thyroid Peroxidase in Vivo without an Apparent Hypothyroid Effect AN - 17727065; 4795913 AB - Biological effects of genistein are currently under investigation by the National Toxicology Program because of widespread and increasing soy consumption by humans and evidence for modulation of endocrine function. Rats were exposed to genistein aglycone in soy-free feed fortified at 0, 5, 100, and 500 ppm starting in utero through 20 weeks. Thyroid glands and serum were analyzed for total genistein (aglycone + conjugates) using HPLC with electrospray mass spectrometric detection. Microsomal thyroid peroxidase (TPO) activity was measured spectrophotometrically. The total genistein content in rat serum was as high as 8 mu M, and significant dose-dependent increases of genistein in thyroid tissue up to 1 pmol/mg were found in male and female rats. The activity of TPO in male and female rats was found to be reduced by up to 80% in a dose-dependent manner. Male and female rats consuming a standard soy-based rodent diet (NIH 31) had TPO activity approximately 50% lower than rats consuming a soy-free diet and this loss was commensurate with measured serum levels of isoflavones. Suicide inactivation of rat, porcine, and human TPO was observed in vitro at concentrations of genistein aglycone comparable to those measured in rat thyroids. Thyroid hormone levels (T3, T4, TSH) in serum, thyroid weights, and histopathology showed no differences between treated and untreated groups. These findings suggest that, even though substantial amounts of TPO activity are lost concomitant to soy isoflavone consumption by normal rats, the remaining enzymatic activity is sufficient to maintain thyroid homeostasis in the absence of additional perturbations. JF - Toxicology and Applied Pharmacology AU - Chang, H C AU - Doerge AD - Division of Biochemical Toxicology, Jefferson, 72079, Arkansas, ddoerge@nctr.fda.gov Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 244 EP - 252 PB - Academic Press VL - 168 IS - 3 SN - 0041-008X, 0041-008X KW - rats KW - Toxicology Abstracts KW - Peroxidase KW - Hypothyroidism KW - Thyroid hormone KW - Endocrine system KW - Dietary intake KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17727065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Dietary+Genistein+Inactivates+Rat+Thyroid+Peroxidase+in+Vivo+without+an+Apparent+Hypothyroid+Effect&rft.au=Chang%2C+H+C%3BDoerge&rft.aulast=Chang&rft.aufirst=H&rft.date=2000-11-01&rft.volume=168&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1006%2Ftaap.2000.9019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dietary intake; Thyroid hormone; Hypothyroidism; Peroxidase; Endocrine system DO - http://dx.doi.org/10.1006/taap.2000.9019 ER - TY - JOUR T1 - Biotransformation of the isoflavonoids biochanin A, formononetin, and glycitein by Eubacterium limosum AN - 17722432; 4782100 AB - Eubacterium limosum (ATCC 8486), a strict anaerobe from the human intestinal tract that is capable of O-demethylation of several compounds, was tested for the ability to metabolize three methoxylated isoflavonoids, biochanin A, formononetin, and glycitein. High-performance liquid chromatography elution profiles of metabolites produced from biochanin A, formononetin, and glycitein showed peaks that had identical retention times to authentic genistein, daidzein, and 6,7,4'-trihydroxyisoflavone, respectively. The metabolites were identified, using an on line liquid chromatography-electrospray mass spectrometer. E. limosum produced 61.4 mu M of genistein and 13.2 mu M of daidzein from 100 mu M of biochanin A and formononetin, after 26 days incubation. O-demethylase activity is cell-associated and was not detected in the extracellular fraction of bacterial culture. This is the first study in which conversion of biochanin A, and formononetin to more potent phytoestrogens by a bacterium has been shown. JF - FEMS Microbiology Letters AU - Hur, H-G AU - Rafii, F AD - Division of Microbiology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA, frafii@nctr.fda.gov Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 21 EP - 25 PB - Elsevier VL - 192 IS - 1 SN - 0378-1097, 0378-1097 KW - biotransformation KW - biochanin A KW - formononetin KW - genistein KW - glycitein KW - Microbiology Abstracts B: Bacteriology KW - Biodegradation KW - Eubacterium limosum KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17722432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Biotransformation+of+the+isoflavonoids+biochanin+A%2C+formononetin%2C+and+glycitein+by+Eubacterium+limosum&rft.au=Hur%2C+H-G%3BRafii%2C+F&rft.aulast=Hur&rft.aufirst=H-G&rft.date=2000-11-01&rft.volume=192&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Eubacterium limosum; Biodegradation ER - TY - JOUR T1 - Environmental investigations of Vibrio parahaemolyticus in oysters after outbreaks in Washington, Texas, and New York (1997 and 1998) AN - 17035122; 4795427 AB - Total Vibrio parahaemolyticus densities and the occurrence of pathogenic strains in shellfish were determined following outbreaks in Washington, Texas, and New York. Recently developed nonradioactive DNA probes were utilized for the first time for direct enumeration of V. parahaemolyticus in environmental shellfish samples. V. parahaemolyticus was prevalent in oysters from Puget Sound, Wash.; Galveston Bay, Tex.; and Long Island Sound, N.Y., in the weeks following shellfish-associated outbreaks linked to these areas. However, only two samples (one each from Washington and Texas) were found to harbor total V. parahaemolyticus densities exceeding the level of concern of 10,000 g super(-1). Pathogenic strains, defined as those hybridizing with tdh and/or trh probes, were detected in a few samples, mostly Puget Sound oysters, and at low densities (usually 10 g super(-1) tdh- and/or trh-positive V. parahaemolyticus in environmental oysters should be considered extraordinary. JF - Applied and Environmental Microbiology AU - DePaola, A AU - Kaysner, CA AU - Bowers, J AU - Cook, D W AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528-0158, USA, adepaola@cfsan.fda.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 4649 EP - 4654 VL - 66 IS - 11 SN - 0099-2240, 0099-2240 KW - USA, New York KW - USA, Texas KW - USA, Washington KW - Vibrio parahaemolyticus KW - enumeration KW - gastroenteritis KW - tdh gene KW - trh gene KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts; Pollution Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Environments KW - Human food KW - Pollution effects KW - Microbial contamination KW - Public health KW - Microbiological analysis KW - Seafood KW - Marine KW - Ostreidae KW - ANW, USA, Long Island Sound KW - Pathogenic bacteria KW - Poisoning KW - Brackish KW - Food poisoning KW - Food contamination KW - ASW, USA, Texas, Galveston Bay KW - Hybridization analysis KW - ANW, USA, New York KW - Marine pollution KW - DNA KW - INE, USA, Washington, Puget Sound KW - Gastroenteritis KW - Oyster fisheries KW - O 5040:Processing, Products and Marketing KW - Q1 08201:General KW - O 1010:Viruses, Bacteria, Protists, Fungi and Plants KW - A 01017:Human foods KW - J 02704:Enumeration KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs KW - P 6000:TOXICOLOGY AND HEALTH KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17035122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Environmental+investigations+of+Vibrio+parahaemolyticus+in+oysters+after+outbreaks+in+Washington%2C+Texas%2C+and+New+York+%281997+and+1998%29&rft.au=DePaola%2C+A%3BKaysner%2C+CA%3BBowers%2C+J%3BCook%2C+D+W&rft.aulast=DePaola&rft.aufirst=A&rft.date=2000-11-01&rft.volume=66&rft.issue=11&rft.spage=4649&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Human food; Food poisoning; Microbial contamination; Oyster fisheries; Microbiological analysis; Environments; DNA; Seafood; Gastroenteritis; Hybridization analysis; Marine pollution; Poisoning; Pollution effects; Food contamination; Public health; Ostreidae; ANW, USA, New York; ANW, USA, Long Island Sound; INE, USA, Washington, Puget Sound; ASW, USA, Texas, Galveston Bay; Marine; Brackish ER - TY - JOUR T1 - Transmission of Norwalk virus during a football game AN - 17647328; 4791765 AB - During a college football game in Florida, diarrhea and vomiting developed in many of the members of a North Carolina team. The next day, similar symptoms developed in some of the players on the opposing team. We interviewed those who ate the five meals served to the North Carolina team before the game and some of the players on the opposing team who became ill. Patients with primary cases were members or staff of the team who had vomiting or diarrhea at least 10 hours after but no more than 50 hours after eating a box lunch served the day before the game. Patients with secondary cases had a later onset of symptoms or had symptoms without having eaten the box lunch. Stool samples were examined by electron microscopy and by a reverse-transcription-polymerase-chain-reaction (RT-PCR) assay. The two football teams shared no food or beverages and had no contact off the playing field. Of five meals served to the North Carolina team before the game, only the box lunch was associated with a significant risk of illness (relative risk of illness, 4.1; 95 percent confidence interval, 1.6 to 10.0). The rate of attack among those who ate the box lunch was 62 percent. There were 11 secondary cases among the members and staff of the North Carolina team and 11 such cases among the Florida players. All four stool samples obtained from North Carolina patients were positive for Norwalk-like virus on electron microscopy. All four samples as well as one of two stool samples from players on the Florida team were positive for a Norwalk-like virus of genogroup I on RT-PCR assay; the RT-PCR products had identical sequences. This investigation documents person-to-person transmission of Norwalk virus among players during a football game. Persons with acute gastroenteritis should be excluded from playing contact sports. JF - New England Journal of Medicine AU - Becker, K M AU - Moe, CL AU - Southwick, K L AU - MacCormack, J N AD - Department of Health and Human Services, Office of International and Refugee Health, Rm. 18-105, Parklawn Bldg., 5600 Fishers Ln., Rockville, MD 20857, USA, kbecker@osophs.dhhs.gov Y1 - 2000/10/26/ PY - 2000 DA - 2000 Oct 26 SP - 1223 EP - 1237 VL - 343 IS - 17 SN - 0028-4793, 0028-4793 KW - football games KW - Norwalk virus KW - USA, Florida KW - contact sports KW - disease transmission KW - food-borne diseases KW - football KW - gastroenteritis KW - outbreaks KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Outbreaks KW - Gastroenteritis KW - Food-borne diseases KW - Physical training KW - Disease transmission KW - V 22123:Epidemiology KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17647328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Transmission+of+Norwalk+virus+during+a+football+game&rft.au=Becker%2C+K+M%3BMoe%2C+CL%3BSouthwick%2C+K+L%3BMacCormack%2C+J+N&rft.aulast=Becker&rft.aufirst=K&rft.date=2000-10-26&rft.volume=343&rft.issue=17&rft.spage=1223&rft.isbn=&rft.btitle=&rft.title=New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Norwalk virus; Disease transmission; Physical training; Food-borne diseases; Outbreaks; Gastroenteritis ER - TY - JOUR T1 - Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis. AN - 72336764; 10922372 AB - Vanadium is a metal widely distributed in the environment. Although vanadate-containing compounds exert potent toxic effects on a wide variety of biological systems, the mechanisms controlling vanadate-induced adverse effects remain to be elucidated. The present study investigated the vanadate-induced p53 activation and involvement of reactive oxygen species (ROS) in p53 activation as well as the role of p53 in apoptosis induction by vanadate. Exposure of mouse epidermal JB6 cells to vanadate led to transactivation of p53 activity in a time- and dose-dependent manner. It also caused mitochondrial damage, apoptosis, and generated ROS. Scavenging of vanadate-induced H(2)O(2) by N-acetyl-l-cysteine (a general antioxidant) or catalase (a specific H(2)O(2) inhibitor), or the chelation of vanadate by deferoxamine, resulted in inhibition of p53 activation and cell mitochondrial damage. In contract, an increase in H(2)O(2) generation in response to superoxide dismutase or NADPH enhanced these effects caused by vanadate. Furthermore, vanadate-induced apoptosis occurred in cells expressing wild-type p53 (p53+/+) but was very weak in p53-deficient (p53-/-) cells. These results demonstrate that vanadate induces p53 activation mainly through H(2)O(2) generation, and this activation is required for vanadate-induced apoptosis. JF - The Journal of biological chemistry AU - Huang, C AU - Zhang, Z AU - Ding, M AU - Li, J AU - Ye, J AU - Leonard, S S AU - Shen, H M AU - Butterworth, L AU - Lu, Y AU - Costa, M AU - Rojanasakul, Y AU - Castranova, V AU - Vallyathan, V AU - Shi, X AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2000/10/20/ PY - 2000 DA - 2000 Oct 20 SP - 32516 EP - 32522 VL - 275 IS - 42 SN - 0021-9258, 0021-9258 KW - Reactive Oxygen Species KW - 0 KW - Tumor Suppressor Protein p53 KW - Vanadates KW - 3WHH0066W5 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Mitochondria -- physiology KW - Animals KW - Skin KW - Transfection KW - Kinetics KW - Electron Spin Resonance Spectroscopy KW - Membrane Potentials -- physiology KW - Mice KW - Membrane Potentials -- drug effects KW - Intracellular Membranes -- physiology KW - Acetylcysteine -- pharmacology KW - DNA Fragmentation KW - Cell Line KW - Transcription, Genetic -- drug effects KW - Genes, p53 KW - Vanadates -- pharmacology KW - Apoptosis -- physiology KW - Hydrogen Peroxide -- pharmacology KW - Apoptosis -- drug effects KW - Transcriptional Activation -- physiology KW - Transcriptional Activation -- drug effects KW - Tumor Suppressor Protein p53 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72336764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Vanadate+induces+p53+transactivation+through+hydrogen+peroxide+and+causes+apoptosis.&rft.au=Huang%2C+C%3BZhang%2C+Z%3BDing%2C+M%3BLi%2C+J%3BYe%2C+J%3BLeonard%2C+S+S%3BShen%2C+H+M%3BButterworth%2C+L%3BLu%2C+Y%3BCosta%2C+M%3BRojanasakul%2C+Y%3BCastranova%2C+V%3BVallyathan%2C+V%3BShi%2C+X&rft.aulast=Huang&rft.aufirst=C&rft.date=2000-10-20&rft.volume=275&rft.issue=42&rft.spage=32516&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-20 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of asphalt fume condensate exposure on acute pulmonary responses AN - 17751017; 4813998 AB - Objective: The present study was carried out to characterize the effects of in vitro exposure to paving asphalt fume condensate (AFC) on alveolar macrophage (AM) functions and to monitor acute pulmonary responses to in vivo AFC exposure in rats. Methods: For in vitro studies, rat primary AM cultures were incubated with various concentrations of AFC for 24 h at 37 degree C. AM-conditioned medium was collected and assayed for lactate dehydrogenase (LDH) as a marker of cytotoxicity. Tumor necrosis factor- alpha (TNF- alpha ) and interleukin-1 (IL-1) production were assayed in AM-conditioned medium to monitor AM function. The effect of AFC on chemiluminescence (CL) generated by resting AM or AM in response to zymosan or PMA stimulation was also determined as a marker of AM activity. For in vivo studies, rats received either (1) a single intratracheal (IT) instillation of saline, or 0.1 mg or 0.5 mg AFC and were killed 1 or 3 days later; or (2) IT instillation of saline, or 0.1, 0.5, or 2 mg AFC for three consecutive days and were killed the following day. Differential counts of cells harvested by bronchoalveolar lavage were measured to monitor inflammation. Acellular LDH and protein content in the first lavage fluid were measured to monitor damage. CL generation, TNF- alpha and IL-1 production by AM were assayed to monitor AM function. Results: In vitro AFC exposure at 200 mu g/ml did not induce cytotoxicity, oxidant generation, or IL-1 production by AM, but it did cause a small but significant increase in TNF- alpha release from AM. In vitro exposure of AM to AFC resulted in a significant decline of CL in response to zymosan or PMA stimulation. The in vivo studies showed that AFC exposure did not induce significant neutrophil infiltration or alter LDH or protein content in acellular lavage samples. Macrophages obtained from AFC-exposed rats did not show significant differences in oxidant production or cytokine secretion at rest or in response to LPS in comparison with control macrophages. Conclusions: These results suggest that: (1) in vitro AFC exposure did not adversely affect cell viability or induce the release of high levels of inflammatory cytokines or oxidants; and (2) exposure of rats to AFC did not cause acute pulmonary inflammation or injury, and did not significantly alter AM functions. JF - Archives of Toxicology AU - Ma, J AU - Barger, M AU - Kriech, A AU - Castranova, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505-2888, USA, jym1@cdc.gov Y1 - 2000/10/17/ PY - 2000 DA - 2000 Oct 17 SP - 452 EP - 459 PB - Springer-Verlag VL - 74 IS - 8 SN - 0340-5761, 0340-5761 KW - sephalt fume condensate KW - alveolar macrophages KW - rats KW - asphalt KW - Toxicology Abstracts KW - Macrophages KW - Fumes KW - Lung KW - Petroleum KW - Alveoli KW - X 24151:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17751017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=Effects+of+asphalt+fume+condensate+exposure+on+acute+pulmonary+responses&rft.au=Ma%2C+J%3BBarger%2C+M%3BKriech%2C+A%3BCastranova%2C+V&rft.aulast=Ma&rft.aufirst=J&rft.date=2000-10-17&rft.volume=74&rft.issue=8&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Alveoli; Fumes; Lung; Macrophages; Petroleum ER - TY - JOUR T1 - DNA adduct formation by Fusarium culture extracts: lack of role of fusarin C. AN - 72320164; 11024453 AB - Fusarium fungi have been shown to infect corn and other crops worldwide, and have a significant impact on human health through loss of crops or contamination of food with mycotoxins. Isolates of Fusarium fungi from an area of South Africa with high incidence of esophageal cancer have been shown to induce esophageal and liver cancer in rats. Several isolates of Fusarium fungi were grown on corn to determine if genotoxic products were produced. We report the incubation of methanol extracts of Fusarium verticillioides cultures with DNA in the presence of rat liver fractions (S9) resulted in the formation of a unique DNA adduct that was detected by (32)P-postlabeling. Fusarin C was purified from cultures of Fusarium verticillioides RRC 415, and was not responsible for the formation of the DNA adduct. Treatment of the methanolic extracts with ultraviolet B radiation reduced the fusarin C content in the extract; however, this had no effect on the formation of the DNA adduct following incubation of the extract with DNA and S9. The unique DNA adduct was formed following the incubation of several Fusarium verticillioides isolates from the US and South Africa, while extracts of cultures of Fusarium graminearium and Fusarium sacchari isolates formed very little of the DNA adduct when incubated with DNA and S9. These data suggest that neither fusarin C nor any of its metabolites are responsible for formation of the DNA adduct, and that an unidentified compound is present in F. verticillioides cultures that forms a DNA adduct, and may be important in the etiology of human esophageal cancer. JF - Chemico-biological interactions AU - Bever, R J AU - Couch, L H AU - Sutherland, J B AU - Williams, A J AU - Beger, R D AU - Churchwell, M I AU - Doerge, D R AU - Howard, P C AD - Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research, US Food and Drug Administration, US Public Health Service, 3900 NCTR Road, Jefferson, AR 72079-9205, USA. Y1 - 2000/10/16/ PY - 2000 DA - 2000 Oct 16 SP - 141 EP - 157 VL - 128 IS - 2 SN - 0009-2797, 0009-2797 KW - DNA Adducts KW - 0 KW - Mycotoxins KW - Polyenes KW - Tissue Extracts KW - fusarin C KW - 79748-81-5 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Salmon KW - Drug Stability KW - Animals KW - DNA -- metabolism KW - Liver -- metabolism KW - Male KW - Chromatography, High Pressure Liquid KW - DNA Adducts -- biosynthesis KW - Mycotoxins -- isolation & purification KW - Fusarium -- chemistry KW - Fusarium -- metabolism KW - Polyenes -- toxicity KW - Polyenes -- metabolism KW - Mycotoxins -- metabolism KW - Polyenes -- isolation & purification KW - Mycotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72320164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=DNA+adduct+formation+by+Fusarium+culture+extracts%3A+lack+of+role+of+fusarin+C.&rft.au=Bever%2C+R+J%3BCouch%2C+L+H%3BSutherland%2C+J+B%3BWilliams%2C+A+J%3BBeger%2C+R+D%3BChurchwell%2C+M+I%3BDoerge%2C+D+R%3BHoward%2C+P+C&rft.aulast=Bever&rft.aufirst=R&rft.date=2000-10-16&rft.volume=128&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-07 N1 - Date created - 2000-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of drug effects on the performance of two timing tasks in rats. AN - 72470769; 11124404 AB - Previous evidence suggests that different timing tasks are differentially sensitive to pharmacological manipulation, especially when different values for the temporal parameters are used. The present series of experiments compared the effects of physostigmine, caffeine, pentobarbital, morphine, and naloxone on the performance of a differential reinforcement of low rates with limited hold (DRL-LH) and a temporal response differentiation (TRD) task. In the DRL-LH task, rats were reinforced for responses that occurred 10-14 s from the end of the previous response. In the TRD task, rats were reinforced for responses with a duration of 10-14 s. The peak response time and peak spread of the initiation time distribution (for DRL-LH) or the response duration distribution (for TRD) were used as indices of temporal discrimination. Physostigmine, caffeine, and pentobarbital produced very similar effects on peak response time for both tasks, but the effects of morphine and naloxone were different for the two tasks. Effects on peak spread for the two tasks did not always correspond to changes in peak response time, suggesting that different processes may be measured by these two endpoints. Further, these effects were independent of changes in response rate suggesting that the effects were not due to gross disruptions in motivation or motor control. These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical. JF - Pharmacology, biochemistry, and behavior AU - Popke, E J AU - Mayorga, A J AU - Fogle, C M AU - Paule, M G AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, HFT-132, 3900 NCTR Road, Jefferson, AR 72079-9502, USA. epopke@nctr.fda.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 377 EP - 385 VL - 67 IS - 2 SN - 0091-3057, 0091-3057 KW - Central Nervous System Stimulants KW - 0 KW - Cholinesterase Inhibitors KW - Hypnotics and Sedatives KW - Narcotic Antagonists KW - Narcotics KW - Naloxone KW - 36B82AMQ7N KW - Caffeine KW - 3G6A5W338E KW - Morphine KW - 76I7G6D29C KW - Physostigmine KW - 9U1VM840SP KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Cholinesterase Inhibitors -- pharmacology KW - Animals KW - Naloxone -- pharmacology KW - Analysis of Variance KW - Central Nervous System Stimulants -- pharmacology KW - Dose-Response Relationship, Drug KW - Physostigmine -- pharmacology KW - Caffeine -- pharmacology KW - Narcotics -- pharmacology KW - Hypnotics and Sedatives -- pharmacology KW - Pentobarbital -- pharmacology KW - Morphine -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Time Factors KW - Narcotic Antagonists -- pharmacology KW - Male KW - Behavior, Animal -- drug effects KW - Task Performance and Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72470769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Comparison+of+drug+effects+on+the+performance+of+two+timing+tasks+in+rats.&rft.au=Popke%2C+E+J%3BMayorga%2C+A+J%3BFogle%2C+C+M%3BPaule%2C+M+G&rft.aulast=Popke&rft.aufirst=E&rft.date=2000-10-01&rft.volume=67&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Misclassification of physical work exposures as a design issue for musculoskeletal intervention studies. AN - 72437750; 11103839 AB - This study determined the impact of misclassification due to using job titles as surrogate variables for physical work exposures to assess confounding in a study of the preventive effect of back belts on back injury. The authors present retail merchandise data that quantify misclassification from residual confounding by physical work exposures on injury rate ratios when available administrative job titles are used. Job title and direct observation data on 134 workers were used to calculate the percentage to which the job-title-adjusted rate ratio for back injury accounts for confounding by the true physical work exposures, awkward postures, and heavy weight handling. Workers' compensation data, an estimate of the effect of back belts from the literature, and the percentage of adjustment of the rate ratio due to the job title variable were used to calculate the magnitude of bias from the rate ratio adjusted for job title. The job title variable was found to have sensitivities of 97% and 85% and specificities of 68% and 58% for awkward postures and heavy weight handling, respectively. The magnitude of confounding bias remaining for the back-injury rate ratio when the job title surrogate was used was 24% for postures and 45% for heavy weight handling. The administrative job title performed poorly in this setting; residual confounding was sufficient to bias the rate ratio from 2.0 to 1.3. The effect of additional sources of misclassification and the need for better exposure measures than job title are discussed. JF - Scandinavian journal of work, environment & health AU - Gardner, L I AU - Landsittel, D P AU - Nelson, N A AU - Pan, C S AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. lig0@cdc.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 406 EP - 413 VL - 26 IS - 5 SN - 0355-3140, 0355-3140 KW - Index Medicus KW - Humans KW - Confounding Factors (Epidemiology) KW - Pilot Projects KW - Workers' Compensation -- statistics & numerical data KW - Lifting KW - Models, Theoretical KW - Musculoskeletal Diseases -- prevention & control KW - Occupational Diseases -- prevention & control KW - Back Injuries -- prevention & control KW - Work KW - Occupational Diseases -- epidemiology KW - Bias (Epidemiology) KW - Musculoskeletal Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72437750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Misclassification+of+physical+work+exposures+as+a+design+issue+for+musculoskeletal+intervention+studies.&rft.au=Gardner%2C+L+I%3BLandsittel%2C+D+P%3BNelson%2C+N+A%3BPan%2C+C+S&rft.aulast=Gardner&rft.aufirst=L&rft.date=2000-10-01&rft.volume=26&rft.issue=5&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment. AN - 72388961; 11067776 AB - Differences in biotransformation activities may alter the bioavailability or efficacy of drugs, provide protection from certain xenobiotic and environmental agents, or increase toxicity of others. Cytochrome P450 (CYP450) enzymes are responsible for the majority of oxidation reactions of drugs and other xenobiotics and differences in their expression may directly produce interindividual differences in susceptibility to compounds whose toxicity is modulated by these enzymes. To rapidly quantify CYP450 forms in human hepatic microsomes, we developed, and applied, an ELISA to 40 samples of microsomes from adult human organ donors. The procedure was reliable and the results were reproducible within normal limits. Protein content for CYP1A, CYP2E1, and CYP3A positively correlated with suitable marker activities. CYP1A, CYP2B, CYP2C6, CYP2C11, CYP2E1, and CYP3A protein content demonstrated 36-, 13-, 11-, 2-, 12-, and 22-fold differences between the highest and lowest samples and the values were normally distributed. Of the forms examined, CYP3A was expressed in the highest amount and it was the only form whose content was correlated with total CYP450 content. Content of other forms was independent of total CYP450. We further determined the contribution of specific forms to the biotransformation of trichloroethylene as a model substrate. CYP2E1 was strongly correlated with chloral hydrate formation from trichloroethylene; CYP2B displayed the strongest correlation with trichloroethanol formation. These data describing the expression and distribution of these forms in human microsomes can be used to extrapolate in vitro derived metabolic rates for toxicologically important reactions, when form selectivity and specific activity are known. This approach may be applied to refine estimates of human interindividual differences in susceptibility for application in human health risk assessment. JF - Regulatory toxicology and pharmacology : RTP AU - Snawder, J E AU - Lipscomb, J C AD - Taft Laboratory, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 200 EP - 209 VL - 32 IS - 2 SN - 0273-2300, 0273-2300 KW - Isoenzymes KW - 0 KW - Xenobiotics KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - No-Observed-Adverse-Effect Level KW - Humans KW - Adult KW - Enzyme-Linked Immunosorbent Assay KW - Aged KW - Middle Aged KW - Male KW - Isoenzymes -- metabolism KW - Female KW - Risk Assessment KW - Cytochrome P-450 Enzyme System -- genetics KW - Xenobiotics -- metabolism KW - Microsomes, Liver -- enzymology KW - Genetic Variation -- physiology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72388961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Interindividual+variance+of+cytochrome+P450+forms+in+human+hepatic+microsomes%3A+correlation+of+individual+forms+with+xenobiotic+metabolism+and+implications+in+risk+assessment.&rft.au=Snawder%2C+J+E%3BLipscomb%2C+J+C&rft.aulast=Snawder&rft.aufirst=J&rft.date=2000-10-01&rft.volume=32&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of different postures for scaffold end-frame disassembly. AN - 72366269; 11059464 AB - Overexertion and fall injuries comprise the largest category of nonfatal injuries among scaffold workers. This study was conducted to identify the most favourable scaffold end-frame disassembly techniques and evaluate the associated slip potential by measuring whole-body isometric strength capability and required coefficient of friction (RCOF) to reduce the incidence of injury. Forty-six male construction workers were used to study seven typical postures associated with scaffold end-frame disassembly. An analysis of variance (ANOVA) showed that the isometric forces (334.4-676.3 N) resulting from the seven postures were significantly different (p < 0.05). Three of the disassembly postures resulted in considerable biomechanical stress to workers. The symmetric front-lift method with hand locations at knuckle height would be the most favourable posture; at least 93% of the male construction worker population could handle the end frame with minimum overexertion risk. The static RCOF value resulting from this posture during the disassembly phase was less than 0.2, thus the likelihood of a slip should be low. JF - Applied ergonomics AU - Cutlip, R AU - Hsiao, H AU - Garcia, R AU - Becker, E AU - Mayeux, B AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV 26505, USA. rgc8@cdc.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 507 EP - 513 VL - 31 IS - 5 SN - 0003-6870, 0003-6870 KW - Index Medicus KW - Anthropometry KW - Accidents, Occupational -- prevention & control KW - Isometric Contraction -- physiology KW - Analysis of Variance KW - Random Allocation KW - Humans KW - Linear Models KW - Adult KW - Accidental Falls -- prevention & control KW - Middle Aged KW - Adolescent KW - Muscles -- physiology KW - Male KW - Occupational Health -- statistics & numerical data KW - Posture -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72366269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+ergonomics&rft.atitle=A+comparison+of+different+postures+for+scaffold+end-frame+disassembly.&rft.au=Cutlip%2C+R%3BHsiao%2C+H%3BGarcia%2C+R%3BBecker%2C+E%3BMayeux%2C+B&rft.aulast=Cutlip&rft.aufirst=R&rft.date=2000-10-01&rft.volume=31&rft.issue=5&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Applied+ergonomics&rft.issn=00036870&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asthma-like symptoms in wood product plant workers exposed to methylene diphenyl diisocyanate. AN - 72341650; 11035694 AB - Diisocyanates, a group of highly reactive chemicals, have frequently been associated with occupational asthma. We evaluated respiratory health in workers at a new wood products manufacturing plant that uses methylene diphenyl diisocyanate (MDI), and was designed and operated with a goal of minimizing worker exposures. Health surveys using standardized respiratory questionnaires were done prior to the initial use of diisocyanates in the plant, and semiannually thereafter for a period of 2 years. Other testing included occupational and work practice histories, serial peak flow measurements, spirometry, methacholine challenge, and measurement of specific IgE antibodies to MDI-albumin conjugate. Of 214 plant employees who participated in at least one health survey, a follow-up survey was also available from 178 employees (83%). New-onset asthma-like symptoms (NAS) were reported by 15 of 56 workers (27%) in areas with the highest potential for exposures to liquid MDI monomer and prepolymer, vs 0 of 43 workers in the lowest potential exposure areas (p = 0.001). In the areas with high potential exposure, NAS developed in 47% of workers who had noted MDI skin staining, vs 19% without skin stains (p = 0.07). Working around and cleaning up liquid MDI represented a significant risk for asthma-like symptoms in both current smokers and nonsmokers; work with finished wood products did not. Asthma-like symptoms were associated with variable airflow limitation (odds ratio [OR], 5.0; confidence interval [CI], 1.4 to 18.7) and specific IgE to MDI-albumin (OR, 3.2; CI, 1.1 to 9.0), but not with skin prick tests to common aeroallergens (OR, 1.1; CI, 0.5 to 2.7). During the first 2 years of operation, in a plant designed and operated to control exposure to diisocyanates, the development of asthma-like symptoms was reported in a relatively high proportion of the employees who worked with liquid MDI. To prevent asthma symptoms among workers, careful control of respiratory tract exposures associated with liquid MDI is important, especially during cleanup activities. Strict limitation of skin contact with diisocyanates may also be necessary. JF - Chest AU - Petsonk, E L AU - Wang, M L AU - Lewis, D M AU - Siegel, P D AU - Husberg, B J AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 1183 EP - 1193 VL - 118 IS - 4 SN - 0012-3692, 0012-3692 KW - Air Pollutants, Occupational KW - 0 KW - Allergens KW - Isocyanates KW - 4,4'-diphenylmethane diisocyanate KW - 101-68-8 KW - Abridged Index Medicus KW - Index Medicus KW - Respiratory Function Tests KW - Odds Ratio KW - Diagnosis, Differential KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Confidence Intervals KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Occupational Diseases -- diagnosis KW - Asthma -- epidemiology KW - Air Pollutants, Occupational -- adverse effects KW - Isocyanates -- adverse effects KW - Wood KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Asthma -- diagnosis KW - Asthma -- chemically induced KW - Allergens -- adverse effects KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72341650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Asthma-like+symptoms+in+wood+product+plant+workers+exposed+to+methylene+diphenyl+diisocyanate.&rft.au=Petsonk%2C+E+L%3BWang%2C+M+L%3BLewis%2C+D+M%3BSiegel%2C+P+D%3BHusberg%2C+B+J&rft.aulast=Petsonk&rft.aufirst=E&rft.date=2000-10-01&rft.volume=118&rft.issue=4&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-15 N1 - Date created - 2000-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methods to lower the dust exposure of bag machine operators and bag stackers. AN - 72336967; 11036726 AB - This article reviews various dust control technologies developed over the years at the Pittsburgh Research Laboratory of the National Institute for Occupational Safety and Health (NIOSH) to provide various options and alternatives to lower bag machine operators' and bag stackers' dust exposures. Dust exposure records for the past 20 years show that bag machine operators and bag stackers normally have the highest respirable dust exposures of workers at mineral processing plants. A substantial amount of research has been performed over the years to minimize the dust exposure to these workers and the intent is to present all this information together in one article. Most of the research describes engineering controls that were adapted to existing facilities to reduce the dust generated during bag filling, bag conveying, and bag stacking. In some cases, a single technique succeeded in lowering respirable dust concentrations for all three processes, thus reducing the dust exposure to both the bag machine operator and the bag stacker. In other cases, a technique was developed to specifically reduce the dust exposure of one process or the other. This research also reviews various controls for secondary dust exposure, including general ventilation requirements to mill buildings, the effects of background dust sources, and personal work practices. This information is presented to help industrial hygienists, plant managers, engineers, and workers lower the dust exposure of bag machine operators and bag stackers. JF - Applied occupational and environmental hygiene AU - Cecala, A B AU - Timko, R J AU - Thimons, E D AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pennsylvania, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 751 EP - 765 VL - 15 IS - 10 SN - 1047-322X, 1047-322X KW - Dust KW - 0 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - United States KW - Equipment Design KW - Ventilation KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Occupational Exposure -- prevention & control KW - Silicon Dioxide -- analysis KW - Occupational Exposure -- standards KW - Mining -- standards KW - Silicon Dioxide -- standards KW - Occupational Exposure -- analysis KW - Dust -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72336967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Methods+to+lower+the+dust+exposure+of+bag+machine+operators+and+bag+stackers.&rft.au=Cecala%2C+A+B%3BTimko%2C+R+J%3BThimons%2C+E+D&rft.aulast=Cecala&rft.aufirst=A&rft.date=2000-10-01&rft.volume=15&rft.issue=10&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse drug reactions: a review of relevant factors. AN - 72322409; 11028248 AB - We examined some of the factors that contribute to the development of adverse drug reactions (ADRs) and analyzed postmarketing ADR reports for 22 drugs. The role of metabolic-based drug-drug interaction in the development of ADRs can not be overstated. Assessment of the postmarketing ADR data for 22 drugs revealed that drugs with high potential for eliciting clinically significant ADRs are usually detected and either withdrawn from the market or placed on restricted use within the first year or two of marketing. Postmarketing data could be a useful tool for understanding the ADR profile of drugs if reporting can be adequately monitored and verified. It is hoped that early evaluation of the clinically meaningful factors such as metabolism, pharmacogenetics, and effect of physiologic and pathophysiologic states on the clinical effect of a drug during drug development would significantly reduce the incidence and severity of post-marketing ADRs. JF - Journal of clinical pharmacology AU - Ajayi, F O AU - Sun, H AU - Perry, J AD - Office of Clinical Pharmacology & Biopharmaceutics, Food and Drug Administration, Rockville, Maryland 20857, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 1093 EP - 1101 VL - 40 IS - 10 SN - 0091-2700, 0091-2700 KW - Pharmaceutical Preparations KW - 0 KW - Proteins KW - Index Medicus KW - Pharmaceutical Preparations -- metabolism KW - Risk Factors KW - Humans KW - Proteins -- metabolism KW - Genetic Heterogeneity KW - Adverse Drug Reaction Reporting Systems KW - Drug-Related Side Effects and Adverse Reactions KW - Product Surveillance, Postmarketing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72322409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Adverse+drug+reactions%3A+a+review+of+relevant+factors.&rft.au=Ajayi%2C+F+O%3BSun%2C+H%3BPerry%2C+J&rft.aulast=Ajayi&rft.aufirst=F&rft.date=2000-10-01&rft.volume=40&rft.issue=10&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemoglobin-based blood substitutes and the hazards of blood radicals. AN - 72316108; 11022843 AB - Cell-free hemoglobins, chemically altered or genetically expressed in microbial host systems, have been developed as oxygen-carrying therapeutics. Site-directed modifications are introduced and serve to stabilize the protein molecules in a tetrameric and/or a polymeric functional form. Animal studies, as well as recent clinical studies, have suggested these proteins probably deliver oxygen to tissues. However, concerns still persist regarding the interference of hemoglobin and its oxidation products with the vascular redox balance, potentially impeding its clinical usefulness. This article reviews our current understanding of heme-mediated toxicities and some of the emerging protective strategies used to overcome hemoglobin side reactions. JF - Free radical research AU - Alayash, A I AD - Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, Maryland 20892, USA. alayash@cber.fda.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 341 EP - 348 VL - 33 IS - 4 SN - 1071-5762, 1071-5762 KW - Blood Substitutes KW - 0 KW - Free Radicals KW - Hemoglobins KW - Recombinant Proteins KW - Solutions KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - Recombinant Proteins -- adverse effects KW - Nitric Oxide -- metabolism KW - Hemoglobins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72316108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+research&rft.atitle=Hemoglobin-based+blood+substitutes+and+the+hazards+of+blood+radicals.&rft.au=Alayash%2C+A+I&rft.aulast=Alayash&rft.aufirst=A&rft.date=2000-10-01&rft.volume=33&rft.issue=4&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Free+radical+research&rft.issn=10715762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Infant immunization with acellular pertussis vaccines in the United States: assessment of the first two years' data from the Vaccine Adverse Event Reporting System (VAERS). AN - 72308346; 11015546 AB - To evaluate the safety of infant immunization with acellular pertussis vaccines in the United States. The US Food and Drug Administration approved the first acellular pertussis vaccine for use in infants in the United States on July 31, 1996. Adverse events in the United States after infant immunization with pertussis-containing vaccines, representing temporal (but not necessarily causal) associations between vaccinations and adverse events. Reports to the Vaccine Adverse Event Reporting System (VAERS), a passive national surveillance system. Reports concerning infant immunization against pertussis between January 1, 1995 (when whole-cell vaccine was in exclusive use) and June 30, 1998 (when acellular vaccine was in predominant use) were analyzed, if the reports were entered into the VAERS database by November 30, 1998. During the study, there were 285 reports involving death, 971 nonfatal serious reports, and 4514 less serious reports after immunization with any pertussis-containing vaccine. For 1995 there were 2071 reports; in 1996 there were 1894 reports; in 1997 there were 1314 reports, and in the first half of 1998 there were 491 reports. Diphtheria-tetanus-pertussis vaccine (DTP) was cited in 1939 reports, diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b vaccine (DTPH) in 2918 reports, and diphtheria-tetanus-acellular pertussis vaccine (DTaP) in 913 reports. The annual number of deaths during the study was 85 in 1995, 82 in 1996, 77 in 1997, and 41 in the first half of 1998. The annual number of reported events categorized as nonfatal serious (defined as events involving initial hospitalization, prolongation of hospitalization, life-threatening illness, or permanent disability) to VAERS for all pertussis-containing vaccines declined: 334 in 1995, 311 in 1996, 233 in 1997, and 93 in the first half of 1998. Similarly, the annual number of less serious reports to VAERS for pertussis-containing vaccines declined: 1652 in 1995, 1501 in 1996, 1004 in 1997, and 357 in the first half of 1998. A comparison of the adverse event profiles (proportional distributions) for DTaP, DTP, and DTPH, as well as an analysis of specific adverse events considered in a 1991 Institute of Medicine report on the safety of diphtheria-tetanus-pertussis vaccine, did not identify any new, clear safety concerns. These findings reflect the administration of millions of doses of acellular pertussis vaccine and are reassuring with regard to the safety of marketed acellular pertussis vaccines. VAERS data, although subject to the limitations of passive surveillance, support the prelicensure data with regard to the safety of the US-licensed acellular pertussis vaccines that we evaluated. JF - Pediatrics AU - Braun, M M AU - Mootrey, G T AU - Salive, M E AU - Chen, R T AU - Ellenberg, S S AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA. braunm@cber.fda.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 1 VL - 106 IS - 4 KW - Diphtheria-Tetanus-Pertussis Vaccine KW - 0 KW - Diphtheria-Tetanus-acellular Pertussis Vaccines KW - Haemophilus Vaccines KW - Pertussis Vaccine KW - Vaccines, Acellular KW - diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine KW - Index Medicus KW - Vaccines, Acellular -- adverse effects KW - Humans KW - Birth Rate KW - Diphtheria-Tetanus-Pertussis Vaccine -- adverse effects KW - Infant Mortality KW - Haemophilus Vaccines -- adverse effects KW - Cause of Death KW - Population Surveillance KW - Central Nervous System Diseases -- chemically induced KW - Infant KW - United States Food and Drug Administration KW - Diphtheria-Tetanus-acellular Pertussis Vaccines -- adverse effects KW - Adverse Drug Reaction Reporting Systems KW - United States -- epidemiology KW - Pertussis Vaccine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72308346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Infant+immunization+with+acellular+pertussis+vaccines+in+the+United+States%3A+assessment+of+the+first+two+years%27+data+from+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29.&rft.au=Braun%2C+M+M%3BMootrey%2C+G+T%3BSalive%2C+M+E%3BChen%2C+R+T%3BEllenberg%2C+S+S&rft.aulast=Braun&rft.aufirst=M&rft.date=2000-10-01&rft.volume=106&rft.issue=4&rft.spage=E51&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-31 N1 - Date created - 2000-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypotonic-hyporesponsive episodes reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998. AN - 72306281; 11015547 AB - A hypotonic-hyporesponsive episode (HHE) is the sudden onset of hypotonia, hyporesponsiveness, and pallor or cyanosis that occurs within 48 hours after childhood immunizations. This syndrome has been primarily associated with pertussis-containing vaccines administered to children <2 years of age, and has been estimated to occur once every 1750 diphtheria-tetanus-pertussis (DTwP) vaccinations. Previous studies of HHE were limited by small numbers of cases and, sometimes, by limited details of the event. To characterize a large number of HHE cases reported to the Vaccine Adverse Event Reporting System (VAERS), to assist clinicians in identifying HHE, and to assist researchers in investigating the risk factors, cause, and pathogenesis of this syndrome. More than 40,000 VAERS reports received between 1996 and 1998 were screened for HHE by a computer algorithm and reviewed, and a telephone follow-up questionnaire was administered to the witness of HHE. There were 215 HHE cases, all nonfatal. The median age of onset of HHE was 4.0 months (range: 1.1-107 months). Over half of the reports (53%) concerned females. The median birth weight was 3. 36 kg (range: 1.27-4.96 kg); 4.7% had a birth weight 24 months of age. There were no relevant findings regarding family medical history or the mothers' gestational history. Nearly all of the children (98.6%) returned to their prevaccination state according to the telephone questionnaire; median time to return was 6 hours (range: 1 minute- 4 months). The 3 children reported as not returning to their prevaccination state all had VAERS reports submitted after they developed conditions (autism, complex partial epilepsy, and developmental delays with infantile spasms) that are not known to be causally associated with immunization. The vast majority of children (93%) with HHE received a pertussis-containing vaccine, either diphtheria-tetanus-acellular pertussis (DTaP, 28%), DTwP (11%), or diphtheria-tetanus-pertussis-Haemophilus influenzae type b (DTwP-HIB, 61%). During the HHE episode, 90.1% of the children had pallor and 49% had cyanosis. Because of the HHE event, 6.8% of children had had all vaccines withheld as of the date of the interview. Of the remainder, 66.5% of children have had 1 or more subsequent vaccinations or vaccine components withheld, and 26.7% have not had any subsequent vaccinations withheld. Only 1 child was reported to have had a repeat episode of HHE, occurring after hepatitis B vaccination. From 1996 to 1998, the number of HHE reports decreased from 99 to 38, when the predominant pertussis vaccine administered to infants changed from whole-cell to acellular. This study represents the largest published case series of children with HHE and supports the generally benign, self-limited, nonrecurrent nature of this syndrome. Although HHE has been less frequently reported to VAERS after increased use of DTaP, HHE does occur after the administration of DTaP and other nonpertussis-containing vaccines. Although most parents and pediatricians withheld the pertussis component of subsequent vaccinations, many did not, with no reported adverse events occurring in the children after the subsequent immunizations. Restricting the definition of HHE to a more narrow age range (eg, <2 years of age) is also proposed because most of the older children probably experienced vasovagal syncope rather than HHE within 5 minutes of immunization. JF - Pediatrics AU - DuVernoy, T S AU - Braun, M M AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852-1428, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 1 VL - 106 IS - 4 KW - Pertussis Vaccine KW - 0 KW - Vaccines, Acellular KW - Vaccines, Combined KW - Viral Vaccines KW - Index Medicus KW - United States KW - Infant KW - Vaccines, Acellular -- adverse effects KW - Cyanosis -- chemically induced KW - Adverse Drug Reaction Reporting Systems KW - Vaccines, Combined -- adverse effects KW - Humans KW - Surveys and Questionnaires KW - Child KW - Male KW - Female KW - Child, Preschool KW - Pertussis Vaccine -- adverse effects KW - Viral Vaccines -- adverse effects KW - Muscle Hypotonia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72306281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Hypotonic-hyporesponsive+episodes+reported+to+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29%2C+1996-1998.&rft.au=DuVernoy%2C+T+S%3BBraun%2C+M+M&rft.aulast=DuVernoy&rft.aufirst=T&rft.date=2000-10-01&rft.volume=106&rft.issue=4&rft.spage=E52&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-31 N1 - Date created - 2000-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improved template preparation for PCR-based assays for detection of food-borne bacterial pathogens. AN - 72297697; 11010913 AB - Shigella flexneri, Salmonella enterica serotype Typhimurium, and Listeria monocytogenes were applied to FTA filters, and the filters were used directly as templates to demonstrate their sensitivity and applicability in PCR-based detection assays. With pure cultures, the sensitivities of detection by FTA filter-based PCR were 30 to 50 and 200 CFU for the gram-negative enterics and Listeria, respectively. Different numbers of S. flexneri cells were used in controlled contamination experiments with several different foods (produce, beef, and apple cider). Aliquots from concentrated food washes subsequently spotted onto FTA filters and assayed by PCR gave consistently positive results and detection limits similar to those observed with pure-culture dilutions. This universal method for PCR template preparation from bacterial cells is rapid and highly sensitive and reduces interference from food-associated inhibitors of PCR. In addition, its broad applicability eliminates the need for multiple methods for analysis of food matrices. JF - Applied and environmental microbiology AU - Lampel, K A AU - Orlandi, P A AU - Kornegay, L AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA. kal@codon.nih.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 4539 EP - 4542 VL - 66 IS - 10 SN - 0099-2240, 0099-2240 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Cattle KW - Fruit -- microbiology KW - Beverages -- microbiology KW - Meat -- microbiology KW - Templates, Genetic KW - Listeria monocytogenes -- isolation & purification KW - Listeria monocytogenes -- genetics KW - Food Microbiology KW - Shigella flexneri -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Polymerase Chain Reaction -- instrumentation KW - Shigella flexneri -- genetics KW - Salmonella typhimurium -- isolation & purification KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72297697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Improved+template+preparation+for+PCR-based+assays+for+detection+of+food-borne+bacterial+pathogens.&rft.au=Lampel%2C+K+A%3BOrlandi%2C+P+A%3BKornegay%2C+L&rft.aulast=Lampel&rft.aufirst=K&rft.date=2000-10-01&rft.volume=66&rft.issue=10&rft.spage=4539&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biotechniques. 2000 Feb;28(2):346-50 [10683746] Emerg Infect Dis. 1999 Sep-Oct;5(5):626-34 [10511518] J Infect Dis. 1989 Jun;159(6):1126-8 [2656880] J Bacteriol. 1990 Apr;172(4):1905-15 [1690703] Lett Appl Microbiol. 1990 Jan;10(1):23-6 [1366573] Mol Cell Probes. 1990 Oct;4(5):353-65 [2280781] J Appl Bacteriol. 1991 May;70(5):372-9 [1908450] Appl Environ Microbiol. 1991 Dec;57(12):3529-34 [1785928] Adv Clin Chem. 1992;29:161-96 [1585849] J Bacteriol. 1992 Jul;174(13):4338-49 [1624429] Appl Environ Microbiol. 1993 May;59(5):1289-93 [8517730] Lett Appl Microbiol. 1994 Nov;19(5):294-8 [7765440] Biotechniques. 1995 Sep;19(3):426-32 [7495556] Anal Biochem. 1997 May 1;247(2):223-7 [9177681] J Appl Microbiol. 1997 Dec;83(6):727-36 [9449811] Mol Cell Probes. 1998 Apr;12(2):79-83 [9633042] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] J Clin Microbiol. 2000 Jun;38(6):2271-7 [10834988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interactions of hemoglobin with hydrogen peroxide alters thiol levels and course of endothelial cell death. AN - 72296929; 11009476 AB - We investigated cellular injury and death induced by ultrapure human Hb (HbA(0)) and its diaspirin cross-linked derivative DBBF-Hb in normal and glutathione (GSH)-depleted bovine aortic endothelial cells subjected to hydrogen peroxide (H(2)O(2)). HbA(0) underwent extensive degradation and heme loss, whereas DBBF-Hb persisted longer in its ferryl (Fe(4+)) form. The formation of ferryl HbA(0) or ferryl DBBF-Hb was associated with a significant decrease in endothelial cell GSH compared with the addition of H(2)O(2) or Hbs alone. This effect was inhibited by catalase, but not by superoxide dismutase or deferoxamine mesylate. The presence of HbA(0) and DBBF-Hb reduced H(2)O(2)-induced apoptosis, as measured by cell morphology, annexin V binding assay, and caspase inhibition, consistent with the ability to consume H(2)O(2) in an enzyme-like fashion. However, the pattern of cell death and injury produced by HbA(0) and DBBF-Hb appeared to be distinctly different among proteins as well as among cells with and without GSH. These findings may have important implications for the use of cell-free Hb as oxygen therapeutics in patients with coexisting pathologies who may lack antioxidant protective mechanisms. JF - American journal of physiology. Heart and circulatory physiology AU - D'Agnillo, F AU - Alayash, A I AD - Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - H1880 EP - H1889 VL - 279 IS - 4 SN - 0363-6135, 0363-6135 KW - Annexin A5 KW - 0 KW - Hemoglobins KW - Oxidants KW - Sulfhydryl Compounds KW - bis(3,5-dibromosalicyl)sebacate-crosslinked hemoglobin KW - Heme KW - 42VZT0U6YR KW - hemoglobin A(0) KW - 54651-57-9 KW - Hemoglobin A KW - 9034-51-9 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glutathione KW - GAN16C9B8O KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Aorta -- metabolism KW - Animals KW - Aorta -- physiology KW - Humans KW - Glutathione -- metabolism KW - Hemoglobins -- pharmacology KW - Annexin A5 -- metabolism KW - Cell Death -- drug effects KW - Cattle KW - Aorta -- drug effects KW - Cells, Cultured KW - Apoptosis -- drug effects KW - Aorta -- cytology KW - Heme -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Sulfhydryl Compounds -- metabolism KW - Oxidants -- pharmacology KW - Endothelium, Vascular -- cytology KW - Aspirin -- analogs & derivatives KW - Hydrogen Peroxide -- pharmacology KW - Hemoglobin A -- pharmacology KW - Aspirin -- pharmacology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72296929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Heart+and+circulatory+physiology&rft.atitle=Interactions+of+hemoglobin+with+hydrogen+peroxide+alters+thiol+levels+and+course+of+endothelial+cell+death.&rft.au=D%27Agnillo%2C+F%3BAlayash%2C+A+I&rft.aulast=D%27Agnillo&rft.aufirst=F&rft.date=2000-10-01&rft.volume=279&rft.issue=4&rft.spage=H1880&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Heart+and+circulatory+physiology&rft.issn=03636135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Historical respirable quartz exposures of industrial sand workers: 1946-1996. AN - 72252805; 10982979 AB - Besides a clear relationship to silicosis, crystalline silica-quartz-has been associated with lung cancer, nonmalignant renal disease, and auto-immune disease. To study diseases associated with crystalline silica further, NIOSH conducted a cohort mortality study of workers from 18 silica sand plants, which had quarry, crushing, and bagging operations to produce industrial sand. Twelve of these plants also had grinding mills to produce fine silica powder. The historical crystalline silica exposures of workers at these plants were estimated to facilitate exposure-response analyses in the epidemiologic study. NIOSH obtained personal respirable dust measurement records from Mine Safety and Health Administration (MSHA) compliance inspections at all 18 plants and from the archives of seven plants which had collected samples. These samples had been analyzed for quartz content by x-ray diffraction. Although no personal samples were available before 1974, impinger dust measurements were reported for 19 silica sand plants in 1946; these data were converted and used to estimate exposures prior to 1974. Statistical modeling of the samples was used to estimate quartz exposure concentrations for workers in plant-job-year categories from the 1930s when mortality follow-up of the cohort began until 1988 when follow-up stopped. Between 1974 and 1996, there were 4,269 respirable dust samples collected at these 18 plants. The geometric mean quartz concentration was 25.9 microg/m(3) (GSD = 10.9) with a range from less than 1 to 11,700 microg/m(3). Samples below 1 microg/m(3) were given a value of 0.5 microg/m(3). Over one-third of the samples -37%) exceeded the MSHA permissible exposure limit value for quartz (PEL = 10 mg/m(3)/(%quartz + 2)) and half (51%) of the samples exceeded the NIOSH recommended exposure limit (REL=50 microg/m(3)). The samples were collected from workers performing 143 jobs within the 18 plants, but too few samples were collected from many of the jobs to make accurate estimates. Therefore, samples were combined into 10 categories of jobs performing similar tasks or located within the same plant area. The quartz concentrations varied significantly by plant, job, and year. Quartz concentrations decreased over time, with measurements collected in the 1970s significantly greater than those collected later. The modeled exposure estimates improve upon duration of employment as an estimate of cumulative exposure and reduce exposure misclassification due to variation in quartz levels between plants, jobs, and over time. Am. J. Ind. Med. 38:389-398, 2000. Published 2000 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Sanderson, W T AU - Steenland, K AU - Deddens, J A AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226-1998, USA. wts1@cdc.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 389 EP - 398 VL - 38 IS - 4 SN - 0271-3586, 0271-3586 KW - Quartz KW - 14808-60-7 KW - Index Medicus KW - United States KW - Humans KW - Occupational Exposure KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72252805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Historical+respirable+quartz+exposures+of+industrial+sand+workers%3A+1946-1996.&rft.au=Sanderson%2C+W+T%3BSteenland%2C+K%3BDeddens%2C+J+A&rft.aulast=Sanderson&rft.aufirst=W&rft.date=2000-10-01&rft.volume=38&rft.issue=4&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of the inflammatory response to a polydimethylsiloxane implant in male and female Balb/c mice. AN - 71766682; 10941916 AB - The implantation of biomaterials elicits a host response that influences the long-term behavior of implanted medical devices. This foreign body response is governed by cells of the immune system. Because sexual dimorphism in the immune system is well-established, a comparative study of the foreign body response in male and female mice was initiated. Eight-week-old male and female Balb/c mice received two subcutaneous implants in the interscapular region of a smooth peroxide-catalyzed polydimethylsiloxane (PDMS) and were sacrificed at 2, 14, 42, 70, and 105 days after implantation (n = 6 per sex per time point). Controls for each time point underwent the surgical procedure but received no implant. Tissue from the implant or surgical site was fixed, processed, and paraffin-embedded for histopathological evaluation and immunohistochemical (IHC) staining for tumor necrosis factor-alpha TNF-alpha) and interleukin-1 beta (IL-1beta). In control animals, an inflammatory response was observed at 2 days that was decreased by 14 days and absent after 42 days. At 2 and 14 days after PDMS implantation, a mild to moderate inflammatory reaction was observed around implants. The peak response was seen at 14 days, and granulation tissue, composed primarily of fibroblasts, macrophages, and neutrophils, was first observed at this time. After 105 days, the implantation site was surrounded by mature connective tissue, which had minimal numbers of macrophages and neutrophils, with severity scores that did not differ significantly in males and females. The immunostaining for TNF-alpha and IL-1beta followed similar temporal patterns, with both reaching a peak at the two week time point and remaining elevated, compared to level of expression in the controls, throughout the 105 day observation period. Staining for both cytokines in the implanted animals was generally higher in females than in males, although this difference was significant only for IL-1beta. These results suggest subtle differences between males and females in the activity of peri-implant inflammatory cells. JF - Biomaterials AU - Dalu, A AU - Blaydes, B S AU - Lomax, L G AU - Delclos, K B AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 1947 EP - 1957 VL - 21 IS - 19 SN - 0142-9612, 0142-9612 KW - Coated Materials, Biocompatible KW - 0 KW - Dimethylpolysiloxanes KW - Interleukin-1 KW - Silicones KW - Tumor Necrosis Factor-alpha KW - baysilon KW - 63148-62-9 KW - Index Medicus KW - Animals KW - Sex Characteristics KW - Tumor Necrosis Factor-alpha -- analysis KW - Mice KW - Interleukin-1 -- analysis KW - Mice, Inbred BALB C KW - Time Factors KW - Male KW - Female KW - Dimethylpolysiloxanes -- toxicity KW - Silicones -- toxicity KW - Coated Materials, Biocompatible -- toxicity KW - Inflammation -- etiology KW - Prostheses and Implants -- adverse effects KW - Inflammation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71766682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=A+comparison+of+the+inflammatory+response+to+a+polydimethylsiloxane+implant+in+male+and+female+Balb%2Fc+mice.&rft.au=Dalu%2C+A%3BBlaydes%2C+B+S%3BLomax%2C+L+G%3BDelclos%2C+K+B&rft.aulast=Dalu&rft.aufirst=A&rft.date=2000-10-01&rft.volume=21&rft.issue=19&rft.spage=1947&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-28 N1 - Date created - 2000-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fundamentals of coal mine roof support AN - 52038018; 2003-003071 AB - Roof supports can only be understood in conjunction with the rock structure that they support. The strength of the rock depends on geology, and the loads are applied primarily by the in situ and mining-induced stresses. Other factors, such as wider spans and retreat or multiple-seam mining, can also reduce the stability of mine openings. Roof supports are used to help stabilize these openings, but their performance characteristics must be properly matched to the loading environment and ground behavior if they are to succeed. Roof supports include both intrinsic supports, such as roof bolts, and standing supports. The key characteristics of any support include its maximum load-carrying capacity, stiffness, and residual strength. Other important factors are the timing of installation, the stability of the support as it is loaded, and the capability of the support system to provide skin control. This paper explains in practical terms how supports work and the important factors in ensuring that a good support design and application strategy are developed. JF - Information Circular - National Institute for Occupational Safety and Health AU - Mark, Christopher AU - Barczak, Thomas M A2 - Mark, Christopher A2 - Dolinar, Dennis R. A2 - Tuckman, Robert J. A2 - Barczak, Thomas M. A2 - Signer, Stephen P. A2 - Wopat, Priscilla F. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 23 EP - 42 PB - National Institute for Occupational Safety and Health, Pittsburgh, PA KW - mines KW - roof control KW - mining geology KW - stress KW - stiffness KW - coal mines KW - stability KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52038018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.atitle=Fundamentals+of+coal+mine+roof+support&rft.au=Mark%2C+Christopher%3BBarczak%2C+Thomas+M&rft.aulast=Mark&rft.aufirst=Christopher&rft.date=2000-10-01&rft.volume=&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 29 N1 - PubXState - PA N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - #04567 N1 - SubjectsTermNotLitGenreText - coal mines; mines; mining geology; pillars; roof control; stability; stiffness; stress ER - TY - JOUR T1 - Proceedings; New technology for coal mine roof support AN - 52035557; 2003-003070 JF - Information Circular - National Institute for Occupational Safety and Health A2 - Mark, Christopher A2 - Dolinar, Dennis R. A2 - Tuckman, Robert J. A2 - Barczak, Thomas M. A2 - Signer, Stephen P. A2 - Wopat, Priscilla F. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 280 PB - National Institute for Occupational Safety and Health, Pittsburgh, PA KW - engineering geology KW - technology KW - roof control KW - mining geology KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52035557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Proceedings%3B+New+technology+for+coal+mine+roof+support&rft.title=Proceedings%3B+New+technology+for+coal+mine+roof+support&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - PubXState - PA N1 - SuppNotes - Individual paper within scope are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - #04567 N1 - SubjectsTermNotLitGenreText - engineering geology; mining geology; roof control; technology ER - TY - JOUR T1 - Summary of field measurements of roof bolt performance AN - 52034916; 2003-003073 AB - During the 1990s, the former U.S. Bureau of Mines conducted a number of field studies in which the performance of different types of roof bolts were evaluated in different geologic environments. The studies used a standard suite of measurements, including multipoint extensometers, strain-gauged roof bolts, and roof bolt load cells. The sites were chosen to investigate the effect of a variety of parameters, including installed tension, bolt capacity, grout annulus, and horizontal stress orientation. Although not fully successful, the measurements provided valuable insights into each of these issues. They also showed that instrumentation and monitoring have important advantages over observational methods for comparing the performance of different roof bolting systems. JF - Information Circular - National Institute for Occupational Safety and Health AU - Mark, Christopher AU - Dolinar, Dennis R AU - Mucho, Thomas P A2 - Mark, Christopher A2 - Dolinar, Dennis R. A2 - Tuckman, Robert J. A2 - Barczak, Thomas M. A2 - Signer, Stephen P. A2 - Wopat, Priscilla F. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 81 EP - 98 PB - National Institute for Occupational Safety and Health, Pittsburgh, PA KW - United States KW - mining KW - mines KW - underground mining KW - roof control KW - stress KW - coal mines KW - extensometers KW - Harlan County Kentucky KW - Cambria County Pennsylvania KW - bolts KW - longwall mining KW - mining geology KW - Greene County Pennsylvania KW - Kentucky KW - Pennsylvania KW - pillars KW - field studies KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52034916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.atitle=Summary+of+field+measurements+of+roof+bolt+performance&rft.au=Mark%2C+Christopher%3BDolinar%2C+Dennis+R%3BMucho%2C+Thomas+P&rft.aulast=Mark&rft.aufirst=Christopher&rft.date=2000-10-01&rft.volume=&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 14 N1 - PubXState - PA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - #04567 N1 - SubjectsTermNotLitGenreText - bolts; Cambria County Pennsylvania; coal mines; extensometers; field studies; Greene County Pennsylvania; Harlan County Kentucky; Kentucky; longwall mining; mines; mining; mining geology; Pennsylvania; pillars; roof control; stress; underground mining; United States ER - TY - JOUR T1 - Skin failure of roof and rib and support techniques in underground coal mines AN - 52034604; 2003-003074 AB - Skin failures of roof and rib in underground coal mines continue to be a significant safety hazard for mine workers. Skin failures do not usually involve failure of the support systems, but result from rock or coal spalling from between the support elements. For instance, in 1997 more than 800 miners were injured by roof and rib falls, of which 98% were the result of skin failures [Bauer et al. 1999]. Also, nearly 80% of the roof and rib failure injuries occurred at or near the working faces in development sections. The face area is a zone where the potential for skin failure accidents and injuries and for roof and rib failures is high because of mining activity, ground readjustment due to changing stress conditions, and the higher exposure of mine workers. In addition, failures occur where the roof and rib are unsupported. This paper reviews the roof and rib accident statistics resulting from skin failure, and highlights the incidences by type, numbers and percentage, in-mine location, supported and unsupported roof, and worker activity at the time of injury. Also discussed are the causes of roof and rib skin failures, current and improved support methods and materials for skin surface control, and machine design modifications for improved roof bolter operator protection. It also reviews the historical literature on skin failures and control methods. JF - Information Circular - National Institute for Occupational Safety and Health AU - Bauer, Eric R AU - Dolinar, Dennis R A2 - Mark, Christopher A2 - Dolinar, Dennis R. A2 - Tuckman, Robert J. A2 - Barczak, Thomas M. A2 - Signer, Stephen P. A2 - Wopat, Priscilla F. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 99 EP - 109 PB - National Institute for Occupational Safety and Health, Pittsburgh, PA KW - spalling KW - mining KW - mines KW - failures KW - discontinuities KW - underground mining KW - roof control KW - moisture KW - mining geology KW - stress KW - coal mines KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52034604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.atitle=Skin+failure+of+roof+and+rib+and+support+techniques+in+underground+coal+mines&rft.au=Bauer%2C+Eric+R%3BDolinar%2C+Dennis+R&rft.aulast=Bauer&rft.aufirst=Eric&rft.date=2000-10-01&rft.volume=&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 22 N1 - PubXState - PA N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04567 N1 - SubjectsTermNotLitGenreText - coal mines; discontinuities; failures; mines; mining; mining geology; moisture; roof control; spalling; stress; underground mining ER - TY - JOUR T1 - Load behavior of grouted bolts in sedimentary rock AN - 52034446; 2003-003072 AB - This paper presents an overview of laboratory and field tests on approximately 250 fully grouted roof bolts instrumented with strain gauges in order to study loading behavior. Laboratory work included pull tests, time-dependent tests, and shear tests. The field tests were conducted in 14 different mines extracting different commodities. However, because of the focus of this publication, only the results of tests in 9 coal mines are reported here. In the field tests, all but 14 bolts were loaded by rock movement; these 14 bolts were tested using pull gear. The variables studied included anchorage length, mechanical interlock, time-dependent behavior, shear, installation load, loading rate, and maximum load level. Such information will improve the understanding of the behavior of resin-grouted bolts, which in return will enhance the safety of miners by reducing the occurrence of rock falls. The influences of geology, overburden depth, entry width, mining-induced stresses, and bolt spacing are not described. JF - Information Circular - National Institute for Occupational Safety and Health AU - Signer, Stephen P A2 - Mark, Christopher A2 - Dolinar, Dennis R. A2 - Tuckman, Robert J. A2 - Barczak, Thomas M. A2 - Signer, Stephen P. A2 - Wopat, Priscilla F. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 73 EP - 80 PB - National Institute for Occupational Safety and Health, Pittsburgh, PA KW - mines KW - laboratory studies KW - failures KW - sedimentary rocks KW - mining geology KW - loading KW - behavior KW - coal mines KW - shear tests KW - grouting KW - field studies KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52034446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.atitle=Load+behavior+of+grouted+bolts+in+sedimentary+rock&rft.au=Signer%2C+Stephen+P&rft.aulast=Signer&rft.aufirst=Stephen&rft.date=2000-10-01&rft.volume=&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Information+Circular+-+National+Institute+for+Occupational+Safety+and+Health&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - PubXState - PA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - #04567 N1 - SubjectsTermNotLitGenreText - behavior; coal mines; failures; field studies; grouting; laboratory studies; loading; mines; mining geology; sedimentary rocks; shear tests ER - TY - JOUR T1 - Prevalence of Rupture of Silicone Gel Breast Implants Revealed on MR Imaging in a Population of Women in Birmingham, Alabama AN - 20675111; 9432735 AB - OBJECTIVE. Silicone gel breast implants have been reported to rupture, but the prevalence of implant rupture in an unreferred population of women is not known. The objective of this study was to assess the prevalence of implant rupture and the presence of extracapsular silicone gel in an unreferred population of women without regard to the absence or presence of any local or systemic symptoms. SUBJECTS AND METHODS. Women identified as part of a National Cancer Institute cohort study on breast implants, living in the Birmingham, AL, area were invited to undergo MR imaging of their current silicone gel breast implants at the Kirklin Clinic at the University of Alabama at Birmingham. Three radiologists independently examined and rated all MR images for signs of implant rupture and extracapsular silicone. RESULTS. A total of 344 women with silicone gel breast implants underwent MR imaging. Breast implant rupture was reported by at least two of three radiologists for 378 (55.0%) of the 687 implants in this study. Another 50 implants (7.2%) were rated as indeterminate (suspicious) for rupture. A majority of women in this study, 265 (77.0%) of 344, had at least one breast implant that was rated as ruptured or indeterminate. Radiologists also agreed that silicone gel could be seen outside the fibrous capsule that forms around the implant in 85 (12.4%) of the 687 implants affecting 73 women (21.2%). Factors that affected implant rupture were implant age and location (submuscular or subglandular). The median implant age at rupture was estimated to be 10.8 years with a 95% confidence interval of 8.4-13.9 years. CONCLUSION. The prevalence of silent or occult silicone gel breast implant rupture is higher than was previously suspected. Most women in this study had MR imaging evidence of at least one ruptured silicone gel breast implant. JF - American Journal of Roentgenology AU - Brown, S L AU - Middleton AU - Berg, WA AU - Soo AU - Pennello, G AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Dr., HFZ-541, Rockville, MD 20850, USA Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 1057 EP - 1064 VL - 175 IS - 4 SN - 0361-803X, 0361-803X KW - Biotechnology and Bioengineering Abstracts KW - Age KW - Silicones KW - Magnetic resonance imaging KW - Computed tomography KW - Rupture KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20675111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=Prevalence+of+Rupture+of+Silicone+Gel+Breast+Implants+Revealed+on+MR+Imaging+in+a+Population+of+Women+in+Birmingham%2C+Alabama&rft.au=Brown%2C+S+L%3BMiddleton%3BBerg%2C+WA%3BSoo%3BPennello%2C+G&rft.aulast=Brown&rft.aufirst=S&rft.date=2000-10-01&rft.volume=175&rft.issue=4&rft.spage=1057&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Roentgenology&rft.issn=0361803X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Silicones; Computed tomography; Magnetic resonance imaging; Rupture ER - TY - JOUR T1 - Differentiation between Types and Strains of Clostridium botulinum by Riboprinting AN - 18387355; 5382091 AB - The ability of automated ribotyping to differentiate between major types and individual strains of Clostridium botulinum was tested using the Qualicon Riboprinter Microbial Characterization System. Pure spores of C. botulinum type A, proteolytic type B, nonproteolytic type B, and type E strains were inoculated onto modified anaerobic egg yolk agar and incubated 24 h at 35 degree C. Plates were rinsed with buffer (2 mM Tris + 20 mM EDTA) to remove vegetative cells that were heated for 10 min at 80 degree C, treated with a lysing agent, and ribotyped in the Qualicon Riboprinter utilizing the enzyme EcoRI. Riboprint patterns were obtained for 30 strains of the four major types of C. botulinum most commonly involved in human foodborne botulism. Proteolytic strains yielded the best and most consistent results. Fifteen ribogroups were identified among the 31 strains tested. Interestingly, in two cases, a single ribogroup contained patterns from isolates belonging to evolutionarily distinct Clostridium lineages. This degree of differentiation between strains of C. botulinum may be useful in hazard analysis and identification, hazard analysis and critical control point monitoring and validation, environmental monitoring, and in inoculation studies. JF - Journal of Food Protection AU - Skinner, GE AU - Gendel, S M AU - Fingerhut, G A AU - Ulaszek, J AU - Solomon, HA AD - U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 1347 EP - 1352 VL - 63 IS - 10 SN - 0362-028X, 0362-028X KW - ribotyping KW - Microbiology Abstracts B: Bacteriology KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18387355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Differentiation+between+Types+and+Strains+of+Clostridium+botulinum+by+Riboprinting&rft.au=Skinner%2C+GE%3BGendel%2C+S+M%3BFingerhut%2C+G+A%3BUlaszek%2C+J%3BSolomon%2C+HA&rft.aulast=Skinner&rft.aufirst=GE&rft.date=2000-10-01&rft.volume=63&rft.issue=10&rft.spage=1347&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Tuberculosis (TB) and HIV infection are independently associated with elevated serum concentrations of tumour necrosis factor receptor type 1 and beta sub(2)-microglobulin, respectively AN - 18247393; 5306893 AB - The aim of this study was to identify immune markers that are independently associated with HIV infection or TB in vivo. Using commercially available assays, we measured concentrations of five immune markers in sera from 175 out-patients attending medical clinics in Cote D'Ivoire and Ghana, West Africa. Patients were categorized into groups with TB only (TB super(+)HIV super(-), n = 55), TB and HIV co-infection (TB super(+)HIV super(+), n = 50), HIV infection only (TB super(-)HIV super(+), n = 35), or neither infection (TB super(-)HIV super(-), n = 35). TB super(+)HIV super(+) and TB super(-)HIV super(+) groups were matched for blood CD4 super(+) lymphocyte count. Mean plus or minus s.d. concentrations of beta sub(2)-microglobulin were similarly increased in both the TB super(-)HIV super(+) (5.3 plus or minus 2.1 mu g/ml, P < 0.0001) and the TB super(+)HIV super(+) (5.0 plus or minus 1.5 mu g/ml, P < 0.0001) groups compared with the TB super(-)HIV super(-) group (2.2 plus or minus 1.8 mu g/ml), but were only slightly increased in the TB super(+)HIV super(-) group (3.2 plus or minus 1.8 mu g/ml, P = 0.01). In contrast, mean serum concentrations of soluble tumour necrosis factor receptor type I (sTNF-RI) were similarly elevated in the TB super(+)HIV super(-) (1873 plus or minus 799 pg/ml, P < 0.0001) and TB super(+)HIV super(+) (1797 plus or minus 571 pg/ml, P < 0.0001) groups compared with uninfected subjects (906 plus or minus 613 pg/ml), but there was only a small increase in sTNF-RI in the TB super(-)HIV super(+) group (1231 plus or minus 165 pg/ml, P = 0.03). Both TB and HIV infection were associated with substantial elevation of serum concentrations of soluble CD8, soluble CD54, and sTNF-R type II. Analysis of additional samples from groups of TB super(+)HIV super(-) and TB super(+)HIV super(+) patients receiving anti-TB treatment showed significant and equal reductions in mean serum sTNF-RI concentrations, but no significant change in mean beta sub(2)-microglobulin. Thus, serum beta sub(2)-microglobulin and sTNF-RI serve as relatively independent markers of HIV infection and TB, respectively, in studies of co-infected persons. JF - Clinical and Experimental Immunology AU - Lawn, S D AU - Rudolph, D AU - Wiktor, S AU - Coulibaly, D AU - Ackah, A AU - Lal, R B AD - HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA, and Projet Retro-CI and Centres Antituberculeux, Abidjan, Cote D'Ivoire, West Africa, sil3@cdc.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 79 EP - 84 PB - Blackwell Science Ltd VL - 122 IS - 1 SN - 0009-9104, 0009-9104 KW - infection KW - man KW - HIV KW - beta -Microglobulin KW - beta 2-microglobulin KW - tumor necrosis factor receptors KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - b2-microglobulin KW - ^b-Microglobulin KW - Ghana KW - Acquired immune deficiency syndrome KW - Tumor necrosis factor KW - Human immunodeficiency virus KW - Africa, West KW - Tuberculosis KW - Cote d'Ivoire KW - Markers KW - Mycobacterium tuberculosis KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms KW - V 22003:AIDS: Immunological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18247393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Experimental+Immunology&rft.atitle=Tuberculosis+%28TB%29+and+HIV+infection+are+independently+associated+with+elevated+serum+concentrations+of+tumour+necrosis+factor+receptor+type+1+and+beta+sub%282%29-microglobulin%2C+respectively&rft.au=Lawn%2C+S+D%3BRudolph%2C+D%3BWiktor%2C+S%3BCoulibaly%2C+D%3BAckah%2C+A%3BLal%2C+R+B&rft.aulast=Lawn&rft.aufirst=S&rft.date=2000-10-01&rft.volume=122&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Experimental+Immunology&rft.issn=00099104&rft_id=info:doi/10.1046%2Fj.1365-2249.2000.01341.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Human immunodeficiency virus; Cote d'Ivoire; Ghana; Africa, West; Tuberculosis; Acquired immune deficiency syndrome; Markers; Tumor necrosis factor DO - http://dx.doi.org/10.1046/j.1365-2249.2000.01341.x ER - TY - JOUR T1 - Semen Quality and Hormone Levels Among Radiofrequency Heater Operators AN - 18163031; 4791982 AB - Approximately 9,000,000 US workers are occupationally exposed to radiofrequency (RF) radiation; over 250,000 operate RF dielectric heaters. Our purpose was to determine whether male RF heater operators experience increased adverse reproductive effects reflected in reduced semen quality or altered hormone levels. We measured incident RF heater radiation exposures and RF-induced foot currents at four companies. For 12 male heater operators and a comparison group of 34 RF-unexposed men, we measured 33 parameters of semen quality and four serum hormones. Despite wide variation in individual exposure levels, near field strengths and induced foot currents did not exceed current standard levels and guidelines. We observed minor semen quality and hormonal differences between the groups, including a slightly higher mean follicle-stimulating hormone level for exposed operators (7.6 vs 5.8 mIU/mL). Further occupational studies of RF-exposed men may be warranted. JF - Journal of Occupational and Environmental Medicine AU - Grajewski, B AU - Cox, C AU - Schrader, S M AU - Murray, W E AU - Edwards, R M AU - Turner, T W AU - Smith, J M AU - Shekar, S S AU - Evenson, D P AU - Simon, S D AU - Conover, D L AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mail Stop R-44, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 993 EP - 1005 VL - 42 IS - 10 SN - 1076-2752, 1076-2752 KW - radiofrequency KW - man KW - hormones KW - semen KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Hormones KW - Radiation KW - Semen KW - Reproduction KW - Occupational exposure KW - H 8000:Radiation Safety/Electrical Safety KW - X 24210:Radiation & radioactive materials KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18163031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Semen+Quality+and+Hormone+Levels+Among+Radiofrequency+Heater+Operators&rft.au=Grajewski%2C+B%3BCox%2C+C%3BSchrader%2C+S+M%3BMurray%2C+W+E%3BEdwards%2C+R+M%3BTurner%2C+T+W%3BSmith%2C+J+M%3BShekar%2C+S+S%3BEvenson%2C+D+P%3BSimon%2C+S+D%3BConover%2C+D+L&rft.aulast=Grajewski&rft.aufirst=B&rft.date=2000-10-01&rft.volume=42&rft.issue=10&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reproduction; Radiation; Occupational exposure; Semen; Hormones ER - TY - JOUR T1 - Staphylococcal enterotoxins AN - 17726383; 4786819 AB - Staphylococcus aureus is a major human pathogen that produces a wide array of toxins, thus causing various types of disease symptoms. Staphylococcal enterotoxins (SEs), a family of nine major serological types of heat stable enterotoxins, are a leading cause of gastroenteritis resulting from consumption of contaminated food. In addition, SEs are powerful superantigens that stimulate non-specific T-cell proliferation. SEs share close phylogenetic relationships, with similar structures and activities. Here we review the structure and function of each known enterotoxin. JF - International Journal of Food Microbiology AU - Balaban, N AU - Rasooly, A AD - Center of Veterinary Medicine, US Food and Drug Administration, Washington DC, USA, axr@vm.cfsan.fda.gov Y1 - 2000/10/01/ PY - 2000 DA - 2000 Oct 01 SP - 1 EP - 10 VL - 61 IS - 1 SN - 0168-1605, 0168-1605 KW - Staphylococcus aureus KW - enterotoxins KW - food poisoning KW - gastroenteritis KW - Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Superantigens KW - Reviews KW - Food poisoning KW - Enterotoxins KW - Gastroenteritis KW - Food contamination KW - A 01017:Human foods KW - H 4000:Food and Drugs KW - A 01023:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17726383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Staphylococcal+enterotoxins&rft.au=Balaban%2C+N%3BRasooly%2C+A&rft.aulast=Balaban&rft.aufirst=N&rft.date=2000-10-01&rft.volume=61&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Reviews; Food contamination; Enterotoxins; Gastroenteritis; Food poisoning; Superantigens ER - TY - JOUR T1 - Testing the potential of flaxseed to affect spermatogenesis: morphometry AN - 17726312; 4789713 AB - Quantitative information was collected on male reproductive effects of maternal and postnatal dietary exposure to flaxseed (20 or 40%), flaxmeal (13 or 26%) or standard NIH AIN-93 feed (0% flaxseed control). Measurements were made on the testes of F1 generation males rats (1) whose mothers were exposed to the diets designated above, and (2) who, after weaning, were placed on the same diet as their mothers for an additional 70 days. The seminiferous tubules comprised 86%, 84%, 84%, 84% and 85% of the total testis volume while the interstitial space comprised 12%, 14%, 14%, 14%, 13% of the total testis volume for the 0% flaxseed/flaxmeal, 20% flaxseed, 13% flaxmeal, 40% flaxseed and 26% flaxmeal groups, respectively. Statistically significant decreases in the absolute volume of the seminiferous tubules were observed in the 20% and 40% flaxseed-treated groups when these groups were compared to controls. Borderline statistically significant differences were also observed when Sertoli cell nucleolar number per tubular cross-section were compared in the 13% flaxmeal and 20% flaxseed treatment groups. These effects were not considered biologically significant because other parameters of male reproductive function appeared normal. Overall, the quantitative information obtained suggests that exposure to flaxseed/flaxmeal at the doses used in the present study does not adversely affect testis structure or spermatogenesis in the rat. JF - Food and Chemical Toxicology AU - Sprando, R L AU - Collins, TFX AU - Wiesenfeld, P AU - Babu, U S AU - Rees, C AU - Black, T AU - Olejnik, N AU - Rorie, J AD - Division of Toxicological Research, Center for Food Safety Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Beltsville, MD 20708, USA, RLS@vm.cfsan.fda.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 887 EP - 892 VL - 38 IS - 10 SN - 0278-6915, 0278-6915 KW - rats KW - linseed KW - Toxicology Abstracts KW - Seminiferous tubule KW - Testes KW - Sexual reproduction KW - Spermatogenesis KW - Linum usitatissimum KW - X 24120:Food, additives & contaminants KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17726312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Testing+the+potential+of+flaxseed+to+affect+spermatogenesis%3A+morphometry&rft.au=Sprando%2C+R+L%3BCollins%2C+TFX%3BWiesenfeld%2C+P%3BBabu%2C+U+S%3BRees%2C+C%3BBlack%2C+T%3BOlejnik%2C+N%3BRorie%2C+J&rft.aulast=Sprando&rft.aufirst=R&rft.date=2000-10-01&rft.volume=38&rft.issue=10&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Linum usitatissimum; Testes; Sexual reproduction; Seminiferous tubule; Spermatogenesis ER - TY - JOUR T1 - Influence of melatonin on immunotoxicity of lead AN - 17707236; 4776315 AB - The results suggested that immunotoxicity induced by lead [Pb, as Pb(NO sub(3)) sub(2)] was significantly restored or prevented by melatonin (MLT). MLT (10 or 50 mg/kg) was orally administered to ICR mice daily for 28 days, and Pb was also administered at 35 mg/kg in the same way 2 h after the administration of MLT, and the normal mice were given vehicle. Within the Pb plus MLT-treated group, the body weight gains and the relative thymus weights were significantly increased when compared with the treatment of Pb alone. The relative spleen and liver weights were increased by the treatment of Pb alone, and then restored to normal value by MLT treatment. Hemagglutination (HA) titer, plaque-forming cell response to sheep red blood cell (SRBC), and secondary IgG antibody response to BSA were significantly enhanced in the Pb plus MLT-treated mice, as opposed to when compared with the treatment of Pb alone. The mitogenic response of splenic T cell to concanavalin A and that of B cells to lipopolysaccharide was remarkably increased by MLT treatment when compared with treatment of Pb alone. Splenic CD4 super(+) cells were significantly increased by MLT treatment when compared with treatment of Pb alone. In case of CD8 super(+) cells, the slight enhancement was observed in MLT treatment. Splenic T and B cells were significantly increased by MLT treatment when compared with the treatment of Pb alone. The natural killer cell, phagocytic activity and the number of peripheral leukocytes were significantly enhanced in Pb plus MLT-treated mice when compared with the treatment of Pb alone. JF - International Journal of Immunopharmacology AU - Kim, Young-Ok AU - Pyo, Myoung-Yun AU - Kim, Joung-Hoon AD - Immunotoxicology Division, Toxicology Department, National Institute of Toxicological Research, Korea FDA, Eunpyung-Ku, Seoul 122-704, South Korea, okjutwo@yahoo.com Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 821 EP - 832 VL - 22 IS - 10 SN - 0192-0561, 0192-0561 KW - toxicity KW - mice KW - immunology KW - lead KW - melatonin KW - Toxicology Abstracts; Immunology Abstracts KW - Sheep red blood cells KW - Heavy metals KW - Lymphocytes B KW - Natural killer cells KW - Spleen KW - Antibody response KW - Hemagglutination KW - Lead KW - Immunotoxicity KW - Immune response (cell-mediated) KW - Liver KW - Immunoglobulin G KW - Lymphocytes T KW - Melatonin KW - Phagocytosis KW - X 24164:Pathology KW - F 06793:Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17707236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Immunopharmacology&rft.atitle=Influence+of+melatonin+on+immunotoxicity+of+lead&rft.au=Kim%2C+Young-Ok%3BPyo%2C+Myoung-Yun%3BKim%2C+Joung-Hoon&rft.aulast=Kim&rft.aufirst=Young-Ok&rft.date=2000-10-01&rft.volume=22&rft.issue=10&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lymphocytes T; Lymphocytes B; Sheep red blood cells; Immunoglobulin G; Antibody response; Spleen; Liver; Hemagglutination; Heavy metals; Melatonin; Lead; Immunotoxicity; Natural killer cells; Phagocytosis; Immune response (cell-mediated) ER - TY - JOUR T1 - Purification and characterization of a cytotonic protein expressed in vitro by the live cholera vaccine candidate CVD 103-HgR AN - 17696462; 4783904 AB - Cholera vaccines developed by the deletion of CTX genes from Vibrio cholerae induce a residual reactogenicity in up to 10% of vaccinees. A novel cytotonic agent named secreted CHO cell elongating protein (S-CEP) was purified from culture supernatants of CVD 103-HgR (Levine et al., Lancet ii:467-470, 1988). Five fractionation steps yielded electrophoretically pure S-CEP with an M sub(r) of 79,000. A partially purified preparation caused fluid accumulation in the sealed infant mouse model. The amino terminus bore a unique sequence with strong homology to a cytotonic toxin of El Tor V. cholerae. JF - Infection and Immunity AU - Sathyamoorthy, V AU - Hall, R H AU - McCardell, BA AU - Kothary, M H AU - Ahn, S J AU - Ratnayake, Sh AD - Food and Drug Administration, CFSAN/DVA/HFS 327, Washington, DC 20204, USA, rhh@cfsan.fda.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 6062 EP - 6065 VL - 68 IS - 10 SN - 0019-9567, 0019-9567 KW - S-CEP protein KW - ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - Molecular structure KW - Human diseases KW - Deletion mutant KW - Electrophoresis KW - Amino acids KW - Pathogenic bacteria KW - Chromatography KW - Animal models KW - Freshwater KW - Toxins KW - Vibrio cholerae KW - Genes KW - Live KW - Vaccines KW - Q1 08206:Physiology, biochemistry, biophysics KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17696462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Purification+and+characterization+of+a+cytotonic+protein+expressed+in+vitro+by+the+live+cholera+vaccine+candidate+CVD+103-HgR&rft.au=Sathyamoorthy%2C+V%3BHall%2C+R+H%3BMcCardell%2C+BA%3BKothary%2C+M+H%3BAhn%2C+S+J%3BRatnayake%2C+Sh&rft.aulast=Sathyamoorthy&rft.aufirst=V&rft.date=2000-10-01&rft.volume=68&rft.issue=10&rft.spage=6062&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Molecular structure; Human diseases; Amino acids; Genes; Pathogenic bacteria; Vaccines; Electrophoresis; Deletion mutant; Chromatography; Live; Animal models; Toxins; Vibrio cholerae; Freshwater ER - TY - JOUR T1 - Cloning, expression, and characterization of the katG gene, encoding catalase-peroxidase, from the polycyclic aromatic hydrocarbon-degrading bacterium Mycobacterium sp. strain PYR-1 AN - 17647232; 4795319 AB - A 81-kDa protein from Mycobacterium sp. strain PYR-1 was expressed in response to exposure of the strain to the polycyclic aromatic hydrocarbon pyrene and recovered by two-dimensional gel electrophoresis. The N-terminal sequence of the protein indicated that it was similar to catalase-peroxidase. An oligonucleotide probe designed from this sequence was used to screen a genomic library of Mycobacterium sp. strain PYR-1, and a positive clone, containing a part of the gene encoding the 81-kDa protein, was isolated. A gene-walking technique was used to sequence the entire gene, which was identified as katG for catalase-peroxidase. The deduced KatG protein sequence showed significant homology to KatGII of Mycobacterium fortuitum and clustered with catalase-peroxidase proteins from other Mycobacterium species in a phylogenetic tree. The katG gene was expressed in Escherichia coli to produce a protein with catalase-peroxidase activity. Since the induction of this catalase-peroxidase occurred in pyrene-induced cultures and the exposure of these cultures to hydrogen peroxide reduced pyrene metabolism, our data suggest that this enzyme plays a role in polycyclic aromatic hydrocarbon metabolism by strain PYR-1. JF - Applied and Environmental Microbiology AU - Wang, R-F AU - Wennerstrom, D AU - Gao, W-W AU - Khan, A A AU - Cerniglia, CE AD - Microbiology Division, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA, CCerniglia@nctr.fda.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 4300 EP - 4304 VL - 66 IS - 10 SN - 0099-2240, 0099-2240 KW - cDNA KW - amino acid sequence prediction KW - KatG protein KW - katG gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Polycyclic aromatic hydrocarbons KW - Hydrocarbons KW - Mycobacterium KW - Genotyping KW - Peroxidase KW - Nucleotide sequence KW - Mycobacterium fortuitum KW - Pyrene KW - Catalase KW - Gene expression KW - Hydrogen peroxide KW - Escherichia coli KW - Proteins KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17647232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Cloning%2C+expression%2C+and+characterization+of+the+katG+gene%2C+encoding+catalase-peroxidase%2C+from+the+polycyclic+aromatic+hydrocarbon-degrading+bacterium+Mycobacterium+sp.+strain+PYR-1&rft.au=Wang%2C+R-F%3BWennerstrom%2C+D%3BGao%2C+W-W%3BKhan%2C+A+A%3BCerniglia%2C+CE&rft.aulast=Wang&rft.aufirst=R-F&rft.date=2000-10-01&rft.volume=66&rft.issue=10&rft.spage=4300&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.10.4300-4304.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium; Mycobacterium fortuitum; Escherichia coli; Polycyclic aromatic hydrocarbons; Nucleotide sequence; Catalase; Peroxidase; Pyrene; Hydrogen peroxide; Gene expression; Hydrocarbons; Proteins; Genotyping DO - http://dx.doi.org/10.1128/AEM.66.10.4300-4304.2000 ER - TY - JOUR T1 - Cold shock induction of thermal sensitivity in Listeria monocytogenes AN - 17641165; 4795326 AB - Cold shock at 0 to 15 degree C for 1 to 3 h increased the thermal sensitivity of Listeria monocytogenes. In a model broth system, thermal death time at 60 degree C was reduced by up to 45% after L. monocytogenes Scott A was cold shocked for 3 h. The duration of the cold shock affected thermal tolerance more than did the magnitude of the temperature downshift. The Z values were 8.8 degree C for controls and 7.7 degree C for cold-shocked cells. The D values of cold-shocked cells did not return to control levels after incubation for 3 h at 28 degree C followed by heating at 60 degree C. Nine L. monocytogenes strains that were cold shocked for 3 h exhibited D sub(60) values that were reduced by 13 to 37%. The D-value reduction was greatest in cold-shocked stationary-phase cells compared to cells from cultures in either the lag or exponential phases of growth. In addition, cold-shocked cells were more likely to be inactivated by a given heat treatment than nonshocked cells, which were more likely to experience sublethal injury. The D values of chloramphenicol-treated control cells and chloramphenicol-treated cold-shocked cells were no different from those of untreated cold-shocked cells, suggesting that cold shock suppresses synthesis of proteins responsible for heat protection. In related experiments, the D values of L. monocytogenes Scott A were decreased 25% on frankfurter skins and 15% in ultra-high temperature milk if the inoculated products were first cold shocked. Induction of increased thermal sensitivity in L. monocytogenes by thermal flux shows potential to become a practical and efficacious preventative control method. JF - Applied and Environmental Microbiology AU - Miller, A J AU - Bayles, DO AU - Eblen, BSh AD - U.S. Food & Drug Administration, Center for Food Safety and Applied Nutrition, Mail Stop HFS-32, 200 C Street S.W., Washington, DC 20204, USA, amiller@cfsan.fda.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 4345 EP - 4350 VL - 66 IS - 10 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology KW - Listeria monocytogenes KW - Chloramphenicol KW - Heat tolerance KW - Cold shock KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17641165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Cold+shock+induction+of+thermal+sensitivity+in+Listeria+monocytogenes&rft.au=Miller%2C+A+J%3BBayles%2C+DO%3BEblen%2C+BSh&rft.aulast=Miller&rft.aufirst=A&rft.date=2000-10-01&rft.volume=66&rft.issue=10&rft.spage=4345&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.10.4345-4350.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Listeria monocytogenes; Cold shock; Heat tolerance; Chloramphenicol DO - http://dx.doi.org/10.1128/AEM.66.10.4345-4350.2000 ER - TY - JOUR T1 - Characterization of fluoroquinolone resistance among veterinary isolates of avian Escherichia coli AN - 17636384; 4784083 AB - Fluoroquinolone-resistant avian Escherichia coli isolates from northern Georgia were investigated for gyrA and parC mutations. All isolates contained a mutation in GyrA replacing Ser83 with Leu; seven isolates also contained mutations replacing Asp87 with either Gly or Tyr. Random amplified polymorphic DNA analysis revealed that quinolone-resistant E. coli isolates were genetically diverse. JF - Antimicrobial Agents & Chemotherapy AU - White, D G AU - Piddock, LJV AU - Maurer, J J AU - Zhao, Sh AU - Ricci, V AU - Thayer, S G AD - Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA, dwhite@cvm.fda.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 2897 EP - 2899 VL - 44 IS - 10 SN - 0066-4804, 0066-4804 KW - GyrA protein KW - gyrA gene KW - parC gene KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Genetic variance KW - Fluoroquinolones KW - Drug resistance KW - USA, Georgia KW - Escherichia coli KW - Antibacterial agents KW - Mutation KW - A 01064:Microbial resistance KW - J 02814:Drug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17636384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Characterization+of+fluoroquinolone+resistance+among+veterinary+isolates+of+avian+Escherichia+coli&rft.au=White%2C+D+G%3BPiddock%2C+LJV%3BMaurer%2C+J+J%3BZhao%2C+Sh%3BRicci%2C+V%3BThayer%2C+S+G&rft.aulast=White&rft.aufirst=D&rft.date=2000-10-01&rft.volume=44&rft.issue=10&rft.spage=2897&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.10.2897-2899.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; USA, Georgia; Antibacterial agents; Fluoroquinolones; Drug resistance; Mutation; Genetic variance DO - http://dx.doi.org/10.1128/AAC.44.10.2897-2899.2000 ER - TY - JOUR T1 - Mutations selected in rotavirus enterotoxin NSP4 depend on the context of its expression. AN - 72308083; 11017794 AB - The rotavirus NSP4 protein is cytotoxic when transiently expressed in cells and is capable of inducing secretory diarrhea in neonatal mice. NSP4 consists of 175 amino acids, and sequences important for its toxic effects have been mapped to the carboxy-terminal half of the protein. In this report, we compared NSP4-encoding nucleotide sequences recovered from cell lines engineered to express NSP4 from human rotavirus strain Wa with NSP4 sequences recovered from cells persistently infected with either Wa or simian rotavirus strain SA11. In cells stably transfected with Wa NSP4, we found that proline(138) was changed to either serine or threonine. However, in cells persistently infected with SA11, we found that phenylalanine(33) was changed to leucine, and in cells persistently infected with Wa, no changes were observed in NSP4. Expression of Wa NSP4 in Caco-2 cells resulted in increased cell-doubling times and decreased cell viability in comparison to cells expressing NSP4-serine(138) or NSP4-threonine(138). This result suggests that sequence polymorphism at residue 138 in Wa NSP4 influences the cytotoxicity of the protein. Therefore, mutations in the carboxy-terminal half of NSP4 are selected when NSP4 is expressed in cells in the absence of other viral proteins, but not in the context of viral replication. These findings suggest that cytotoxic functions of NSP4 are not operant during natural rotavirus infection. Copyright 2000 Academic Press. JF - Virology AU - Mohan, K V AU - Dermody, T S AU - Atreya, C D AD - Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2000/09/15/ PY - 2000 DA - 2000 Sep 15 SP - 125 EP - 132 VL - 275 IS - 1 SN - 0042-6822, 0042-6822 KW - Glycoproteins KW - 0 KW - NS28 protein, rotavirus KW - RNA, Messenger KW - Toxins, Biological KW - Viral Nonstructural Proteins KW - Index Medicus KW - Animals KW - DNA Mutational Analysis KW - Humans KW - Polymorphism, Genetic -- genetics KW - Gene Expression KW - RNA, Messenger -- analysis KW - Caco-2 Cells KW - RNA, Messenger -- genetics KW - Cell Survival KW - Virulence KW - Phenotype KW - Transfection KW - Amino Acid Substitution -- genetics KW - Cell Line KW - Cell Division KW - Viral Nonstructural Proteins -- biosynthesis KW - Viral Nonstructural Proteins -- genetics KW - Glycoproteins -- biosynthesis KW - Glycoproteins -- metabolism KW - Glycoproteins -- chemistry KW - Viral Nonstructural Proteins -- chemistry KW - Rotavirus -- pathogenicity KW - Mutation -- genetics KW - Rotavirus -- genetics KW - Glycoproteins -- genetics KW - Viral Nonstructural Proteins -- metabolism KW - Rotavirus -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72308083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Mutations+selected+in+rotavirus+enterotoxin+NSP4+depend+on+the+context+of+its+expression.&rft.au=Mohan%2C+K+V%3BDermody%2C+T+S%3BAtreya%2C+C+D&rft.aulast=Mohan&rft.aufirst=K&rft.date=2000-09-15&rft.volume=275&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-31 N1 - Date created - 2000-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breeds of dogs involved in fatal human attacks in the United States between 1979 and 1998. AN - 72272628; 10997153 AB - To summarize breeds of dogs involved in fatal human attacks during a 20-year period and to assess policy implications. Dogs for which breed was reported involved in attacks on humans between 1979 and 1998 that resulted in human dog bite-related fatalities (DBRF). Data for human DBRF identified previously for the period of 1979 through 1996 were combined with human DBRF newly identified for 1997 and 1998. Human DBRF were identified by searching news accounts and by use of The Humane Society of the United States' registry databank. During 1997 and 1998, at least 27 people died of dog bite attacks (18 in 1997 and 9 in 1998). At least 25 breeds of dogs have been involved in 238 human DBRF during the past 20 years. Pit bull-type dogs and Rottweilers were involved in more than half of these deaths. Of 227 reports with relevant data, 55 (24%) human deaths involved unrestrained dogs off their owners' property, 133 (58%) involved unrestrained dogs on their owners' property, 38 (17%) involved restrained dogs on their owners' property, and 1 (< 1%) involved a restrained dog off its owner's property. Although fatal attacks on humans appear to be a breed-specific problem (pit bull-type dogs and Rottweilers), other breeds may bite and cause fatalities at higher rates. Because of difficulties inherent in determining a dog's breed with certainty, enforcement of breed-specific ordinances raises constitutional and practical issues. Fatal attacks represent a small proportion of dog bite injuries to humans and, therefore, should not be the primary factor driving public policy concerning dangerous dogs. Many practical alternatives to breed-specific ordinances exist and hold promise for prevention of dog bites. JF - Journal of the American Veterinary Medical Association AU - Sacks, J J AU - Sinclair, L AU - Gilchrist, J AU - Golab, G C AU - Lockwood, R AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. Y1 - 2000/09/15/ PY - 2000 DA - 2000 Sep 15 SP - 836 EP - 840 VL - 217 IS - 6 SN - 0003-1488, 0003-1488 KW - Index Medicus KW - Animals KW - Restraint, Physical -- veterinary KW - Animals, Domestic -- physiology KW - Animals, Domestic -- classification KW - Humans KW - Retrospective Studies KW - Animals, Domestic -- psychology KW - Child KW - United States -- epidemiology KW - Male KW - Female KW - Child, Preschool KW - Dogs -- classification KW - Dogs -- psychology KW - Dogs -- physiology KW - Bites and Stings -- mortality KW - Public Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72272628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Veterinary+Medical+Association&rft.atitle=Breeds+of+dogs+involved+in+fatal+human+attacks+in+the+United+States+between+1979+and+1998.&rft.au=Sacks%2C+J+J%3BSinclair%2C+L%3BGilchrist%2C+J%3BGolab%2C+G+C%3BLockwood%2C+R&rft.aulast=Sacks&rft.aufirst=J&rft.date=2000-09-15&rft.volume=217&rft.issue=6&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Veterinary+Medical+Association&rft.issn=00031488&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-20 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a transgenic mouse neurovirulence test for oral poliovirus vaccine: international collaborative study 1993-1999 AN - 17656030; 4767789 AB - The neurovirulence safety of oral live poliovirus vaccine (OPV) has been tested in monkeys, because only primates are sensitive to all three types of poliovirus. The genetic engineering of transgenic mice susceptible to poliovirus led to studies on the suitability of these mice for a neurovirulence test of OPV. A WHO international collaborative study started with type-3 OPV in 1993 and was completed in 1999. The study produced a voluminous set of data proving that the TgPVR21 mice, inoculated with OPV samples into the lumbar cord, provided a test for neurovirulence of OPV as sensitive and reproducible as the monkey test. A statistical decision model for acceptance/rejection of type-3 vaccines using the transgenic mouse test has been developed. The mouse neurovirulence test showed a number of essential advantages over the monkey test. This is the first example of a successful introduction of transgenic animals into control of biologicals. In October 1999, the WHO Expert Committee on Biological Standardization approved TgPVR21 mice as alternative to the monkey model for neurovirulence testing of OPV type 3. A final step of the collaborative study with OPV types 1 and 2 is in progress, and data obtained so far are promising. Two breeding stations for production of TgPVR21 mice are being established in Asia and Europe. JF - Vaccine AU - Levenbook, I AU - Dragunsky, E AU - Pervikov, Y AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA Y1 - 2000/09/15/ PY - 2000 DA - 2000 Sep 15 SP - 163 EP - 166 VL - 19 IS - 2-3 SN - 0264-410X, 0264-410X KW - transgenic mice KW - immunology KW - poliovirus KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Poliovirus KW - International cooperation KW - Safety KW - Neurovirulence KW - Attenuation KW - Nervous system diseases KW - Vaccines KW - W3 33365:Vaccines (other) KW - F 06807:Active immunization KW - V 22150:Animal models & experimentally-induced viral infections KW - V 22097:Immunization: Vaccines & vaccination: Human KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17656030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Development+of+a+transgenic+mouse+neurovirulence+test+for+oral+poliovirus+vaccine%3A+international+collaborative+study+1993-1999&rft.au=Levenbook%2C+I%3BDragunsky%2C+E%3BPervikov%2C+Y&rft.aulast=Levenbook&rft.aufirst=I&rft.date=2000-09-15&rft.volume=19&rft.issue=2-3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Poliovirus; Neurovirulence; Vaccines; International cooperation; Nervous system diseases; Safety; Attenuation ER - TY - JOUR T1 - Postlicensure Safety Surveillance for Varicella Vaccine AN - 17817687; 4858384 AB - Since its licensure in 1995, the extensive use of varicella vaccine and close surveillance of the associated anecdotal reports of suspected adverse effects provide the opportunity to detect potential risks not observed before licensure because of the relatively small sample size and other limitations of clinical trials. To detect potential hazards, including rare events, associated with varicella vaccine, and to assess case reports for clinical and epidemiological implications. Postlicensure case-series study of suspected vaccine adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) from March 17, 1995, through July 25, 1998. Numbers of reported adverse events, proportions, and reporting rates (reports per 100,000 doses distributed). VAERS received 6574 case reports of adverse events in recipients of varicella vaccine, a rate of 67.5 reports per 100,000 doses sold. Approximately 4% of reports described serious adverse events, including 14 deaths. The most frequently reported adverse events were rashes, possible vaccine failures, and injection site reactions. Misinterpretation of varicella serology after vaccination appeared to account for 17% of reports of possible vaccine failures. Among 251 patients with herpes zoster, 14 had the vaccine strain of varicella zoster virus (VZV), while 12 had the wild-type virus. None of 30 anaphylaxis cases was fatal. An immunodeficient patient with pneumonia had the vaccine strain of VZV in a lung biopsy. Pregnant women occasionally received varicella vaccine through confusion with varicella zoster immunoglobulin. Although the role of varicella vaccine remained unproven in most serious adverse event reports, there were a few positive rechallenge reports and consistency of many cases with syndromes recognized as complications of natural varicella. Most of the reported adverse events associated with varicella vaccine are minor, and serious risks appear to be rare. We could not confirm a vaccine etiology for most of the reported serious events; several will require further study to clarify whether varicella vaccine plays a role. Education is needed to ensure appropriate use of varicella serologic assays and to eliminate confusion between varicella vaccine and varicella zoster immunoglobulin. JF - Journal of the American Medical Association AU - Wise, R P AU - Salive, ME AU - Braun, M M AU - Mootrey, G T AU - Seward, J F AU - Rider, L G AU - Krause, PR AD - 1401 Rockville Pike, FDA CBER HFM-225, Rockville, MD 20852-1448, USA, rpwise@cber.fda.gov Y1 - 2000/09/13/ PY - 2000 DA - 2000 Sep 13 SP - 1271 EP - 1279 VL - 284 IS - 10 SN - 0098-7484, 0098-7484 KW - Varicella-zoster virus KW - vaccines KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Safety KW - Vaccines KW - Side effects KW - Immunoglobulins KW - V 22097:Immunization: Vaccines & vaccination: Human KW - A 01097:Viruses KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17817687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=Postlicensure+Safety+Surveillance+for+Varicella+Vaccine&rft.au=Wise%2C+R+P%3BSalive%2C+ME%3BBraun%2C+M+M%3BMootrey%2C+G+T%3BSeward%2C+J+F%3BRider%2C+L+G%3BKrause%2C+PR&rft.aulast=Wise&rft.aufirst=R&rft.date=2000-09-13&rft.volume=284&rft.issue=10&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Varicella-zoster virus; Side effects; Vaccines; Safety; Immunoglobulins ER - TY - JOUR T1 - Determination of chlorophacinone and diphacinone in commercial rodenticides by liquid chromatography-UV detection and liquid chromatography-electrospray ionization mass spectrometry. AN - 72352446; 11043785 AB - This work describes a simple method for the determination and mass-spectrometric confirmation of the indanediones in commercial rodenticides. The sample is sonicated in methanol containing 2% formic acid and analyzed by liquid chromatography-UV detection. Once retention time and UV-Vis spectrum provide tentative identification, mass-spectrometric confirmation is obtained by analyzing a second aliquot by LC and electrospray ionization mass spectrometry (LC-ESI-MS). The extensive fragmentation of the indanedione molecule under MS/MS conditions provides sufficient structural information for positive identification on analyte levels as low as 20 ng on column. JF - Journal of chromatography. A AU - Mesmer, M Z AU - Flurer, R A AD - United States Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA. Y1 - 2000/09/08/ PY - 2000 DA - 2000 Sep 08 SP - 249 EP - 255 VL - 891 IS - 2 SN - 0021-9673, 0021-9673 KW - Indans KW - 0 KW - Rodenticides KW - chlorophacinone KW - 34Y6E0063Y KW - diphenadione KW - 54CA01C6JX KW - Phenindione KW - 5M7Y6274ZE KW - Index Medicus KW - Sensitivity and Specificity KW - Spectrometry, Mass, Electrospray Ionization KW - Spectrophotometry, Ultraviolet KW - Indans -- analysis KW - Chromatography, Liquid -- methods KW - Phenindione -- analysis KW - Rodenticides -- chemistry KW - Phenindione -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72352446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Determination+of+chlorophacinone+and+diphacinone+in+commercial+rodenticides+by+liquid+chromatography-UV+detection+and+liquid+chromatography-electrospray+ionization+mass+spectrometry.&rft.au=Mesmer%2C+M+Z%3BFlurer%2C+R+A&rft.aulast=Mesmer&rft.aufirst=M&rft.date=2000-09-08&rft.volume=891&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in bronchoalveolar lavage indices associated with radiographic classification in coal miners. AN - 85272673; pmid-10988113 AB - Previous studies on symptomatic coal miners have shown that alveolar macrophages, recovered by bronchoalveolar lavage (BAL), release excessive amounts of reactive oxygen species (ROS) and inflammatory cytokines. It has been proposed that these secretions may mediate cell injury and initiate the disease process. We hypothesized that acellular bronchoalveolar lavage fluid (BALF) indices in coal miners chronically exposed to coal dust may reflect the status of important homeostatic modulations in the lung that lead to the development of coal workers' pneumoconiosis (CWP). To test this hypothesis, we measured inflammatory status, oxidant burden, antioxidant defenses, cytokines, growth factors, fibronectin, and alpha(1)-antitrypsin (alpha(1)-AT) in the BALF of healthy never-smoker control subjects, never-smoker underground coal miners with negative radiographs (ILO 0/0-1/0), and two miners with moderate changes in the chest radiographs (ILO 2/2). Interestingly, indices of injury and inflammation increased with the progression of disease in coal miners. Antioxidant enzymes, such as catalase, glutathione peroxidase, and superoxide dismutase, showed a 19-fold, 22-fold, and 6-fold increase above control, respectively, in coal miners with category 2/2 CWP. Significant increases in the secretion of IL-1, IL-6, TNF-alpha, TGF-beta, fibronectin, and alpha(1)-AT also were evident in coal miners with disease. This up-regulation of antioxidant defenses and cytokines was not evident in coal miners in the absence of clinically evident radiographic disease. In addition, the concentration of lipid peroxidation by products in the BALF of coal miners without evidence of radiographic disease showed a moderate 3-fold increase, whereas, in coal miners with category 2/2 CWP it showed a 59-fold increase compared to control subjects. These results are in good agreement with our hypothesis that development of CWP and its progression may be correlated with an oxidative stress and up-regulation of cytokines and mediators of growth. JF - American Journal of Respiratory and Critical Care Medicine AU - Vallyathan, V AU - Goins, M AU - Lapp, L N AU - Pack, D AU - Leonard, S AU - Shi, X AU - Castranova, V AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and Section of Pulmonary and Critical Care Medicine, West Virginia University, Morgantown, West Virginia, USA. PY - 2000 SP - 958 EP - 965 VL - 162 IS - 3 Pt 1 SN - 1073-449X, 1073-449X KW - Lung KW - Human KW - Oxidative Stress KW - Bronchoalveolar Lavage Fluid KW - Adult KW - Pneumoconiosis KW - Middle Age KW - Inflammation Mediators KW - Cytokines KW - Predictive Value of Tests KW - Reactive Oxygen Species KW - Lipid Peroxidation KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85272673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Changes+in+bronchoalveolar+lavage+indices+associated+with+radiographic+classification+in+coal+miners.&rft.au=Vallyathan%2C+V%3BGoins%2C+M%3BLapp%2C+L+N%3BPack%2C+D%3BLeonard%2C+S%3BShi%2C+X%3BCastranova%2C+V&rft.aulast=Vallyathan&rft.aufirst=V&rft.date=2000-09-01&rft.volume=162&rft.issue=3+Pt+1&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Attention deficit/hyperactivity disorder: characteristics, interventions and models. AN - 72467595; 11106857 AB - An epidemiological study of Attention Deficit/Hyperactivity Disorder (ADHD) suggests that the prevalence may be two to three times higher than the figure of 3-5% often cited. In addition, the data suggest that both underdiagnosis and overdiagnosis occur frequently. Rodent animal models of ADHD, like the Spontaneously Hypertensive Rat (SHR) and other rat models such as those with chemical and radiation-induced brain lesions and cerebellar stunting, and the Coloboma mouse model exhibit clear similarities with several aspects of the human disorder and should prove useful in studying specific traits. Operant behavioral tasks that model learning, short-term memory and simple discriminations are sensitive to ADHD and methylphenidate has been shown to normalize ADHD performance in a short-term memory task. Recent findings challenge not only the current postulate that response inhibition is a unique deficit in ADHD, but also the concepts of ADHD and its treatment, which presume intact perceptual abilities. Time perception deficits may account, in part, for the excessive variability in motor response times on speeded reaction time tasks, motor control problems and motor clumsiness associated with ADHD. The Multimodality Treatment Study of ADHD (MTA) provided data suggesting that pharmacological interventions that included systematic and frequent follow-up with parents and teachers, with or without psychosocial interventions, are superior to psychosocial interventions or standard community care alone. Additionally, the MTA was one of the first studies to demonstrate benefits of multimodal and pharmacological interventions lasting longer than 1 year. Imaging studies have demonstrated differences in brain areas in children with ADHD: anterior corpus callosum, right anterior white matter, and cerebellar volumes are all decreased in children with ADHD and there is less brain asymmetry in ADHD subjects. Additionally, functional imaging studies, coupled with pharmacological manipulations, suggest decreased blood flow and energy utilization in prefrontal cortex and striatum and the dysregulation of catecholamine systems in persons with ADHD. JF - Neurotoxicology and teratology AU - Paule, M G AU - Rowland, A S AU - Ferguson, S A AU - Chelonis, J J AU - Tannock, R AU - Swanson, J M AU - Castellanos, F X AD - Behavioral Toxicology Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA. mpaule@nctr.fda.gov PY - 2000 SP - 631 EP - 651 VL - 22 IS - 5 SN - 0892-0362, 0892-0362 KW - Index Medicus KW - Animals KW - Humans KW - Disease Models, Animal KW - Attention Deficit Disorder with Hyperactivity -- therapy KW - Attention Deficit Disorder with Hyperactivity -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72467595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Attention+deficit%2Fhyperactivity+disorder%3A+characteristics%2C+interventions+and+models.&rft.au=Paule%2C+M+G%3BRowland%2C+A+S%3BFerguson%2C+S+A%3BChelonis%2C+J+J%3BTannock%2C+R%3BSwanson%2C+J+M%3BCastellanos%2C+F+X&rft.aulast=Paule&rft.aufirst=M&rft.date=2000-09-01&rft.volume=22&rft.issue=5&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of galactomannans by capillary electrophoresis. AN - 72430713; 11091784 AB - Capillary electrophoresis (CE) was utilized in the characterization of various galactomannans. Standards of gums were extracted with 50% CH3CN to remove the residual proteins from the gum matrix. Separation buffers were optimized with respect to pH, buffer concentration and presence of sodium dodecyl sulphate, yielding protein profiles from which the desired information could be obtained. Examples are given of the profiles generated by various gums and gum blends to aid in the verification of component presence, and to demonstrate levels of adulteration detectable under the buffer conditions used. JF - Food additives and contaminants AU - Flurer, C L AD - Forensic Chemistry Center, US Food and Drug Administration, Cincinnati, Ohio 45237, USA. cflurer@ora.fda.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 721 EP - 731 VL - 17 IS - 9 SN - 0265-203X, 0265-203X KW - Galactans KW - 0 KW - Mannans KW - Plant Extracts KW - Plant Gums KW - Plant Proteins KW - Polysaccharides KW - galactomannan KW - 11078-30-1 KW - guar gum KW - E89I1637KE KW - locust bean gum KW - V4716MY704 KW - Index Medicus KW - Plant Proteins -- analysis KW - Electrophoresis, Capillary -- standards KW - Electrophoresis, Capillary -- methods KW - Galactans -- chemistry KW - Polysaccharides -- chemistry KW - Mannans -- analysis KW - Mannans -- chemistry KW - Plants, Medicinal KW - Food Contamination -- analysis KW - Cassia -- chemistry KW - Plant Extracts -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72430713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Characterization+of+galactomannans+by+capillary+electrophoresis.&rft.au=Flurer%2C+C+L&rft.aulast=Flurer&rft.aufirst=C&rft.date=2000-09-01&rft.volume=17&rft.issue=9&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-13 N1 - Date created - 2000-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A long-term study of the development of N2O controls at a pediatric dental facility. AN - 72400176; 11071429 AB - A review is given of National Institute for Occupational Safety and Health (NIOSH) efforts to control N2O at a pediatric dental operatory from 1978 to the present. Measurements of N2O concentrations were made on four occasions before and after installation of different controls, using an infrared analyzer. Air velocity and volumetric flow measurements also were taken, Video imaging was done in some cases simultaneously with real-time N2O measurements to correlate work practices with exposure data. An infrared imaging system was used to identify sources of N2O. Critical components of resulting recommendations for control include monitoring of N2O concentrations; use of engineering controls, such as a scavenging mask, an effective dilution ventilation system, and auxiliary exhaust; good work practices; maintenance of the equipment; and worker education. Data presented strongly supports the hypothesis that better implementation of controls leads to reduction of N2O exposures. N2O concentrations were reduced by a factor of 61 from their initial levels. The current NIOSH recommended exposure limit of 25 ppm TWA during the time of N2O administration appears to be achievable. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Crouch, K G AU - McGlothlin, J D AU - Johnston, O E AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. PY - 2000 SP - 753 EP - 756 VL - 61 IS - 5 SN - 1529-8663, 1529-8663 KW - Nitrous Oxide KW - K50XQU1029 KW - Index Medicus KW - United States KW - Pediatrics KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Gas Scavengers -- standards KW - Occupational Exposure -- prevention & control KW - Dental Facilities -- standards KW - Occupational Exposure -- standards KW - Nitrous Oxide -- analysis KW - Ventilation -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72400176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=A+long-term+study+of+the+development+of+N2O+controls+at+a+pediatric+dental+facility.&rft.au=Crouch%2C+K+G%3BMcGlothlin%2C+J+D%3BJohnston%2C+O+E&rft.aulast=Crouch&rft.aufirst=K&rft.date=2000-09-01&rft.volume=61&rft.issue=5&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Male adolescent exposure to endocrine-disrupting pesticides: vinclozolin exposure in peripubertal rabbits. AN - 72312721; 11021521 AB - Adolescence is a time of dramatic neuroendocrine changes that are required for sexual maturation. Hormonal mimicking or inhibiting chemicals can cause significant impairment during this critical period. Vinclozolin (Vin) has been shown to be an anti-androgen affecting male offspring in rats in utero, and its mechanism of action may be mediated by inhibition of androgenic receptor action. The majority of teenagers working on farms are male, and therefore a systemic fungicide, vinclozolin, was selected for study. The rabbit has proved to be an excellent species for modelling reproductive toxicant effects in the male and was selected as the test species. The peripubertal phase for the rabbit was determined to be between the 3rd and 4th months. A 2-month dosing period was therefore initiated at 3 months of age and carried through to the 4th month. Vin was administered by dermal application (100 mg kg(-1) in 100 microl of dimethylsulphoxide) daily. Body weights were determined weekly. The rabbits were then held until fully mature (6 months of age). Semen was collected and evaluated from sexually mature males on a weekly schedule for 5 weeks to maximize sperm output. An automated solid phase extraction procedure for monitoring exposures through isolation and quantification of Vin and its metabolic products was developed. Increased plasma levels of Vin and M2 were found throughout the experimental period. The exposed rabbits had a smaller weight gain during pubertal growth (approaching significance; P=0.059). At maturity, the accessory sex glands of the exposed animals weighed less than those of the controls (P=0.016). Surprisingly, the pooled sperm count of the exposed animals was significantly higher (P=0.017) than that of the unexposed animals. The anti-androgenic effects of Vin may have blocked the negative feedback mechanism of testosterone on the hypothalamus or pituitary gland, allowing for an increase in gonadotrophin release, and consequently increasing sperm production at puberty. JF - Andrologia AU - Moorman, W J AU - Cheever, K L AU - Skaggs, S R AU - Clark, J C AU - Turner, T W AU - Marlow, K L AU - Schrader, S M AD - Division of Biomedical and Behavioral Sciences, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 285 EP - 293 VL - 32 IS - 4-5 SN - 0303-4569, 0303-4569 KW - Androgen Antagonists KW - 0 KW - Fungicides, Industrial KW - Oxazoles KW - vinclozolin KW - JJ258EZN1I KW - Index Medicus KW - Rats KW - Occupational Exposure KW - Models, Animal KW - Animals KW - Sperm Count KW - Humans KW - Rabbits KW - Male KW - Sexual Maturation -- drug effects KW - Oxazoles -- metabolism KW - Androgen Antagonists -- toxicity KW - Androgen Antagonists -- metabolism KW - Endocrine Glands -- drug effects KW - Fungicides, Industrial -- metabolism KW - Fungicides, Industrial -- toxicity KW - Oxazoles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72312721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Andrologia&rft.atitle=Male+adolescent+exposure+to+endocrine-disrupting+pesticides%3A+vinclozolin+exposure+in+peripubertal+rabbits.&rft.au=Moorman%2C+W+J%3BCheever%2C+K+L%3BSkaggs%2C+S+R%3BClark%2C+J+C%3BTurner%2C+T+W%3BMarlow%2C+K+L%3BSchrader%2C+S+M&rft.aulast=Moorman&rft.aufirst=W&rft.date=2000-09-01&rft.volume=32&rft.issue=4-5&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Andrologia&rft.issn=03034569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo drug-drug interaction studies--a survey of all new molecular entities approved from 1987 to 1997. AN - 72302975; 11014409 AB - Ninety-eight new molecular entities applications approved between 1987 to 1991 (period I) and 193 applications for new molecular entities between 1992 to 1997 (period II) were surveyed for drug-drug interaction studies. In period I (used as a comparator), 32 applications contained drug-drug interaction studies for a total of 117 studies. In period II, 106 applications reported drug-drug interaction studies, and the number of studies per new molecular entity ranged from 0 to 15. Most studies (77%) were performed in healthy subjects, with 44% using crossover designs, 7% using parallel designs, and the remaining using fixed sequence designs. The most common dosing scheme for new molecular entities/interacting drug was multiple dose (47%), whereas single dose/multiple dose was used in 31% of studies, and single dose/single dose was used in 18% of studies. Of the 540 drug-drug interaction studies submitted in period II, 80 (15%) resulted in clinically significant labeling statements. Submissions for new molecular entities to the Center for Drug Evaluation and Research divisions most likely to include drug-drug interaction studies were neuropharmacology, cardiorenal, antiviral, and antiinfective drugs. Some drug classes such as oncology drug products and radioimaging products were least likely to include drug-drug interaction studies in their submissions. We conclude that the use of drug-drug interaction studies in the drug development process has increased between the two periods. JF - Clinical pharmacology and therapeutics AU - Marroum, P J AU - Uppoor, R S AU - Parmelee, T AU - Ajayi, F AU - Burnett, A AU - Yuan, R AU - Svadjian, R AU - Lesko, L J AU - Balian, J D AD - Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA. marroump@cder.fda.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 280 EP - 285 VL - 68 IS - 3 SN - 0009-9236, 0009-9236 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Drug Administration Schedule KW - United States Food and Drug Administration KW - Dose-Response Relationship, Drug KW - Humans KW - Databases, Factual KW - Cross-Over Studies KW - Clinical Trials as Topic KW - Drug Interactions KW - Biopharmaceutics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72302975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=In+vivo+drug-drug+interaction+studies--a+survey+of+all+new+molecular+entities+approved+from+1987+to+1997.&rft.au=Marroum%2C+P+J%3BUppoor%2C+R+S%3BParmelee%2C+T%3BAjayi%2C+F%3BBurnett%2C+A%3BYuan%2C+R%3BSvadjian%2C+R%3BLesko%2C+L+J%3BBalian%2C+J+D&rft.aulast=Marroum&rft.aufirst=P&rft.date=2000-09-01&rft.volume=68&rft.issue=3&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-17 N1 - Date created - 2000-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Empirical Bayes adjustments for multiple results in hypothesis-generating or surveillance studies. AN - 72297009; 11008906 AB - Traditional methods of adjustment for multiple comparisons (e.g., Bonferroni adjustments) have fallen into disuse in epidemiological studies. However, alternative kinds of adjustment for data with multiple comparisons may sometimes be advisable. When a large number of comparisons are made, and when there is a high cost to investigating false positive leads, empirical or semi-Bayes adjustments may help in the selection of the most promising leads. Here we offer an example of such adjustments in a large surveillance data set of occupation and cancer in Nordic countries, in which we used empirical Bayes (EB) adjustments to evaluate standardized incidence ratios (SIRs) for cancer and occupation among craftsmen and laborers. For men, there were 642 SIRs, of which 138 (21%) had a P 1.0 and 8% negative with SIR < or = 1.0) when testing the null hypothesis of no cancer/occupation association; some of these were probably due to confounding by nonoccupational risk factors (e.g., smoking). After EB adjustments, there were 95 (15%) SIRs with P < 0.05 (10% positive and 5% negative). For women, there were 373 SIRs, of which 37 (10%) had P < 0.05 before adjustment (6% positive and 4% negative) and 13 (3%) had P < 0.05 after adjustment (2% positive and 1% negative). Several known associations were confirmed after EB adjustment (e.g., pleural cancer among plumbers, original SIR 3.2 (95% confidence interval, 2.5-4.1), adjusted SIR 2.0 (95% confidence interval, 1.6-2.4). EB can produce more accurate estimates of relative risk by shrinking imprecise outliers toward the mean, which may reduce the number of false positives otherwise flagged for further investigation. For example, liver cancer among chimney sweepers was reduced from an original SIR of 2.2 (range, 1.1-4.4) to an adjusted SIR of 1.1 (range, 0.9-1.4). A potentially important future application for EB is studies of gene-environment-disease interactions, in which hundreds of polymorphisms may be evaluated with dozens of environmental risk factors in large cohort studies, producing thousands of associations. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Steenland, K AU - Bray, I AU - Greenland, S AU - Boffetta, P AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 895 EP - 903 VL - 9 IS - 9 SN - 1055-9965, 1055-9965 KW - Carcinogens KW - 0 KW - Index Medicus KW - Odds Ratio KW - Analysis of Variance KW - Social Class KW - Humans KW - Incidence KW - Scandinavian and Nordic Countries -- epidemiology KW - Male KW - Female KW - Risk Assessment KW - Occupational Exposure -- statistics & numerical data KW - Neoplasms -- epidemiology KW - Bayes Theorem KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72297009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Empirical+Bayes+adjustments+for+multiple+results+in+hypothesis-generating+or+surveillance+studies.&rft.au=Steenland%2C+K%3BBray%2C+I%3BGreenland%2C+S%3BBoffetta%2C+P&rft.aulast=Steenland&rft.aufirst=K&rft.date=2000-09-01&rft.volume=9&rft.issue=9&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A nationwide outbreak of alopecia associated with the use of a hair-relaxing formulation. AN - 72262451; 10987865 AB - To study the long-term outcome of adverse effects reported by persons who used a commercial hair-straightening product known as the Rio Hair Naturalizer System (World Rio Corporation). Survey of individuals who contacted the Food and Drug Administration in 1994 and 1995 to report adverse effects linked to using the product. Persons residing in the United States. A total of 464 (59% of 790 eligible) patients who returned a completed questionnaire. Adverse effects associated with using the Rio Hair Naturalizer System products (neutral or color enhancer). Ninety percent of respondents were African American women between the ages of 15 and 55 years. The most common complaints associated with the use of the products were hair breakage and/or hair loss, reported by 95% of respondents. Three quarters of those experiencing hair loss reported losing 40% or more of their original hair. The median time between the loss of original hair and the growth of new hair was 8 months; however, 40 (9%) respondents reported having no new growth at the time of completing the survey, some 2 years after using the product. When mixed according to package instructions, the mean pH of a sample of 20 neutral product kits tested was 1.39 (range, 1.1-3.15). For the 21 color-enhancer products tested, the mean pH was 2.82 (range, 2. 29-3.08). A nationwide outbreak of alopecia and scalp injuries involving tens of thousands of women (and some men) occurred following the marketing of a chemical hair-relaxing product. Most of those affected reported substantial hair loss, with a majority indicating growth of new hair that was abnormal in both quantity and quality. JF - Archives of dermatology AU - Swee, W AU - Klontz, K C AU - Lambert, L A AD - Food and Drug Administration, HFS-728, 200 C St SW, Washington, DC 20204, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 1104 EP - 1108 VL - 136 IS - 9 SN - 0003-987X, 0003-987X KW - Hair Preparations KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Product Surveillance, Postmarketing KW - Middle Aged KW - Adolescent KW - African Continental Ancestry Group KW - Male KW - Female KW - Hair Preparations -- adverse effects KW - Disease Outbreaks KW - Alopecia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72262451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=A+nationwide+outbreak+of+alopecia+associated+with+the+use+of+a+hair-relaxing+formulation.&rft.au=Swee%2C+W%3BKlontz%2C+K+C%3BLambert%2C+L+A&rft.aulast=Swee&rft.aufirst=W&rft.date=2000-09-01&rft.volume=136&rft.issue=9&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-03 N1 - Date created - 2000-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sensitization of cancer cells to interleukin 13-pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain. AN - 72261947; 10986556 AB - We have demonstrated that primary interleukin 13 (IL-13) binding protein IL-13 receptor (IL-13R) alpha chain plays an important role in IL-13 binding and internalization in the IL-13R system. Although IL-13R alpha chain is expressed on many cancer cell lines, some cancer types do not express or express low levels of this receptor chain. Consequently, these cells show no or low sensitivity to the cytotoxic effect of a recombinant chimeric protein composed of IL-13 and a mutated form of a Pseudomonas exotoxin, IL13-PE38QQR. Here we demonstrate that pancreatic cancer, renal cell carcinoma, head and neck cancer, and glioblastoma cell lines that were genetically altered to express high levels of IL-13R alpha chain increase their binding affinity for IL-13, and increase their sensitivity to IL13-PE38QQR by at least 6-fold to 1000-fold compared with mock-transfected control cells. This observation was made by protein synthesis inhibition assay and confirmed by clonogenic assay. Our studies provide a proof of principle for a novel strategy for cancer therapy that combines gene transfer and targeted cytotoxin therapy. JF - Human gene therapy AU - Kawakami, K AU - Joshi, B H AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 1829 EP - 1835 VL - 11 IS - 13 SN - 1043-0342, 1043-0342 KW - Antineoplastic Agents KW - 0 KW - Bacterial Toxins KW - Exotoxins KW - IL13RA1 protein, human KW - Interleukin-13 KW - Interleukin-13 Receptor alpha1 Subunit KW - Iodine Radioisotopes KW - Receptors, Interleukin KW - Receptors, Interleukin-13 KW - Recombinant Proteins KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Exotoxins -- genetics KW - Exotoxins -- pharmacology KW - Recombinant Proteins -- pharmacology KW - Tumor Cells, Cultured KW - Transfection KW - Humans KW - Inhibitory Concentration 50 KW - Recombinant Proteins -- genetics KW - Colony-Forming Units Assay KW - Gene Transfer Techniques KW - Interleukin-13 -- metabolism KW - Receptors, Interleukin -- genetics KW - Receptors, Interleukin -- drug effects KW - Cell Death -- genetics KW - Cell Death -- drug effects KW - Antineoplastic Agents -- pharmacology KW - Interleukin-13 -- genetics KW - Interleukin-13 -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72261947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+gene+therapy&rft.atitle=Sensitization+of+cancer+cells+to+interleukin+13-pseudomonas+exotoxin-induced+cell+death+by+gene+transfer+of+interleukin+13+receptor+alpha+chain.&rft.au=Kawakami%2C+K%3BJoshi%2C+B+H%3BPuri%2C+R+K&rft.aulast=Kawakami&rft.aufirst=K&rft.date=2000-09-01&rft.volume=11&rft.issue=13&rft.spage=1829&rft.isbn=&rft.btitle=&rft.title=Human+gene+therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-26 N1 - Date created - 2000-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identifying toxic degradation products in cellulose acetate dialyzers. AN - 72257443; 10984691 AB - In September 1996, seven patients at Hospital A suffered conjunctivitis, hearing loss, diminished vision, and headaches 7-24 h after hemodialysis treatment. Eleven-year-old dialysis modules were identified as a common link between these patients. Degradation of the cellulose acetate (CA) material was identified as the cause of this incident. Degradation products were characterized from retrieved CA dialysis membranes. A series of synthesized CA degradation products was tested in vitro to assess toxicity. Based on the toxicity of the material preparations to the cells, animal tests were performed on selected CA degradation extracts and compared to extracts from actual dialysis membranes. Rabbits were IV-injected with extracts from a 13-year-old dialyzer, synthesized model compounds, and compared to controls. Ophthamological evaluation of the rabbits showed eye injury (iritis/ciliary flush) when the animals were treated with the old dialyzer or synthesized model compounds. Isolation and characterization of a toxic fraction from both of these extracts strongly indicated that oxidative stress at some point in the storage or manufacture of CA dialyzers created degradation products that reproduced some of the patient symptoms identified at Hospital A. JF - Journal of biomedical materials research AU - Lucas, A D AU - Kalson, J A AU - Hutter, J C AU - Wallis, R R AD - U.S. Food and Drug Administration, CDRH/OST, Rockville MD 20852, USA. adl@cdrh.fda.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 449 EP - 456 VL - 53 IS - 5 SN - 0021-9304, 0021-9304 KW - Biocompatible Materials KW - 0 KW - Membranes, Artificial KW - acetylcellulose KW - 3J2P07GVB6 KW - Cellulose KW - 9004-34-6 KW - Index Medicus KW - Biocompatible Materials -- chemistry KW - Animals KW - Biocompatible Materials -- toxicity KW - Vision Disorders -- etiology KW - Cell Survival -- drug effects KW - Humans KW - Jurkat Cells KW - Deafness -- etiology KW - Rabbits KW - Conjunctivitis -- etiology KW - Headache -- etiology KW - Female KW - Cellulose -- analogs & derivatives KW - Renal Dialysis -- standards KW - Cellulose -- toxicity KW - Renal Dialysis -- instrumentation KW - Cellulose -- chemistry KW - Equipment Failure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72257443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomedical+materials+research&rft.atitle=Identifying+toxic+degradation+products+in+cellulose+acetate+dialyzers.&rft.au=Lucas%2C+A+D%3BKalson%2C+J+A%3BHutter%2C+J+C%3BWallis%2C+R+R&rft.aulast=Lucas&rft.aufirst=A&rft.date=2000-09-01&rft.volume=53&rft.issue=5&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomedical+materials+research&rft.issn=00219304&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-03 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of total sulfur compounds and benzothiazole in asphalt fume samples by gas chromatography with sulfur chemiluminescence detection. AN - 72256148; 10983404 AB - As part of a collaborative project between the National Institute for Occupational Safety and Health and the Federal Highway Administration to evaluate asphalt pavers' exposures to asphalt fume and their potential health effects, a method was developed for the determination of total sulfur compounds and benzothiazole in asphalt fume samples. Asphalt fume samples were collected from asphalt mixtures with and without the addition of ground-up rubber tires. The asphalt fume samples were collected with sampling trains that consisted of a Teflon membrane filter and an XAD-2 adsorbent tube. Filter and sampling tube media were extracted with hexane and subsequently analyzed by gas chromatography with a sulfur chemiluminescence detector. Separation was achieved with a 100 percent dimethyl polysiloxane fused silica column. Typical calibration curves had linear correlation coefficients of 0.99 or better with a relative standard deviation (RSD) of 5 percent. Benzothiazole desorption efficiency (DE) determined using spiked sampling tubes ranged from 96.5 percent at 5.0 micrograms to 89.4 percent at 40 micrograms with RSD values from 0.9 to 4.0 percent. Benzothiazole storage recovery determined using sampling tubes spiked at 20 micrograms and refrigerated for 30 days at 4 degrees C was 89.8 percent when corrected for the DE with an RSD of 1.1 percent. The limit of detection for the method determined using spiked sampling tubes was 0.30 microgram. Quantitation for total sulfur compounds and benzothiazole was against benzothiazole standards in hexane. Because of detector selectivity, sample preparation consisted of a simple hexane extraction even when samples had a high background due to hydrocarbon overload. Detector sensitivity provided quantitation in the sub-microgram region. Because of the sample preparation step and because benzothiazole was determined during the same analysis run, this method is straightforward and analytically efficient. The method has been used to analyze asphalt fume samples collected at several asphalt paving and roof operations. JF - Applied occupational and environmental hygiene AU - Jaycox, L B AU - Olsen, L D AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 695 EP - 704 VL - 15 IS - 9 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Benzothiazoles KW - Hydrocarbons KW - Sulfur Compounds KW - Thiazoles KW - asphalt KW - 8052-42-4 KW - benzothiazole KW - G5BW2593EP KW - Index Medicus KW - Occupational Exposure -- prevention & control KW - Luminescent Measurements KW - Humans KW - Industry KW - Hydrocarbons -- chemistry KW - Sulfur Compounds -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Sulfur Compounds -- adverse effects KW - Thiazoles -- adverse effects KW - Thiazoles -- analysis KW - Hydrocarbons -- adverse effects KW - Air Pollutants, Occupational -- chemistry KW - Environmental Monitoring -- methods KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72256148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Determination+of+total+sulfur+compounds+and+benzothiazole+in+asphalt+fume+samples+by+gas+chromatography+with+sulfur+chemiluminescence+detection.&rft.au=Jaycox%2C+L+B%3BOlsen%2C+L+D&rft.aulast=Jaycox&rft.aufirst=L&rft.date=2000-09-01&rft.volume=15&rft.issue=9&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-26 N1 - Date created - 2000-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Noise exposure to airline ramp employees. AN - 72255227; 10983395 JF - Applied occupational and environmental hygiene AU - Tubbs, R L AD - Hazard Evaluation and Technical Assistance Branch of the National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 657 EP - 663 VL - 15 IS - 9 SN - 1047-322X, 1047-322X KW - Index Medicus KW - United States KW - Ear Protective Devices KW - Noise, Transportation -- prevention & control KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Noise, Transportation -- adverse effects KW - Aircraft KW - Hearing Loss, Noise-Induced -- etiology KW - Noise, Occupational -- prevention & control KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Hearing Loss, Noise-Induced -- prevention & control KW - Noise, Occupational -- adverse effects KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72255227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Noise+exposure+to+airline+ramp+employees.&rft.au=Tubbs%2C+R+L&rft.aulast=Tubbs&rft.aufirst=R&rft.date=2000-09-01&rft.volume=15&rft.issue=9&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-26 N1 - Date created - 2000-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of polychlorinated biphenyls on the nervous system. AN - 72247767; 11693948 AB - The neurological effects of polychlorinated biphenyls (PCBs) have been extensively investigated in humans and in animals. The main focus in human studies has been on the effects in neonates and young children, although studies of adults have also been conducted. A great deal of concern exists that even low levels of PCBs transferred to the fetus across the placenta may induce long-lasting neurological damage. Because PCBs are lipophilic substances, there is also concem that significant amounts might be transferred to nursing infants via breast milk. Studies in humans who consumed large amounts of Great Lakes fish contaminated with environmentally persistent chemicals, including PCBs. have provided evidence that PCBs are important contributors to subtle neurobehavioral alterations observed in newborn children and that some of these alterations persist during childhood. Some consistent observations at birth have been motor immaturity and hyporeflexia and lower psychomotor scores between 6 months and 2 years old. There is preliminary evidence that highly chlorinated PCB congeners, which accumulate in certain fish, are associated with neurobehavioral alterations seen in some newbom children. Subtle neurobehavioral alterations have also been observed in children bom to mothers in the general population with the highest PCB body burdens. Because of the limitations of epidemiological studies, these effects cannot be attributed entirely to PCB exposure. In one general population study, there was strong evidence that dioxins, as well as PCBs, were contributors to the neurobehavioral effects seen in exposed children. Children born to women who accidentally consumed rice oil contaminated with relatively high amounts of PCBs and chlorinated dibenzofurans (CDFs) during pregnancy also had neurodevelopmental changes. Studies in animals support the human data. Neurobehavioral alterations have been also observed in rats and monkeys following prenatal and/or postnatal exposure to commercial Aroclor mixtures, defined experimental congener mixtures, single PCB congeners, and Great Lakes contaminated fish. In addition, monkeys exposed postnatally to PCB mixtures of congeneric composition and concentration similar to that found in human breast milk showed learning deficits long after exposure had ceased. A few other generalizations can be made from the data in animals. It appears that ortho-substituted PCB congeners are more active than coplanar PCBs in modifying cognitive processes. In addition, one effect observed in both rats and monkeys--deficits on delayed spatial alternation--has been known to be induced by exposure to ortho-substituted PCBs, defined experimental mixtures, and commercial Aroclors. Both dioxin-like and non-dioxin-like PCB congeners have been shown to induce neurobehavioral alterations in animals. Changes in levels of neurotransmitters in various brain areas have also been observed in monkeys, rats, and mice. Of all the observed changes, the most consistent has been a decrease in dopamine content in basal ganglia and prefrontal cortex, but further research is needed before specific neurobehavioral deficits can be correlated with PCB-induced changes in specific neurotransmitters in specific brain areas. JF - Toxicology and industrial health AU - Faroon, O AU - Jones, D AU - de Rosa, C AD - Agency for Toxic Substances and Disease Registry (ATSDR) US Department of Health and Human Services, Atlanta, Georgia 30333, USA. oxs0@cdc.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 305 EP - 333 VL - 16 IS - 7-8 SN - 0748-2337, 0748-2337 KW - Environmental Pollutants KW - 0 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Administration, Oral KW - Animals KW - Humans KW - Infant, Newborn KW - Child Development -- drug effects KW - Disease Models, Animal KW - Child KW - Haplorhini KW - Pregnancy KW - Environmental Monitoring KW - Fishes KW - Adult KW - Food Contamination KW - Male KW - Female KW - Environmental Pollutants -- toxicity KW - Polychlorinated Biphenyls -- toxicity KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72247767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Effects+of+polychlorinated+biphenyls+on+the+nervous+system.&rft.au=Faroon%2C+O%3BJones%2C+D%3Bde+Rosa%2C+C&rft.aulast=Faroon&rft.aufirst=O&rft.date=2000-09-01&rft.volume=16&rft.issue=7-8&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-08 N1 - Date created - 2001-11-05 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Comment In: Toxicol Ind Health. 2002 Feb;18(1):45-7 [12703682] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Evaluation of in vitro reporter gene induction assays for use in a rapid prescreen for compound selection to test specificity in the Tg.AC mouse short-term carcinogenicity assay. AN - 72221633; 10966510 AB - Under ICH guidelines, short-term carcinogenicity assays such as the Tg.AC assay are allowed alternatives for one species in the 2-year rodent bioassay. The Tg.AC transgenic mouse, which carries the v-Ha-ras oncogene under control of the zeta-globin promoter, develops skin papillomas in response to dermal application of carcinogens and tumor promoters. The appropriate specificity of the Tg.AC model for testing pharmaceuticals has not been systematically evaluated. The selection of candidate test compounds among noncarcinogenic pharmaceuticals would be aided by a high-throughput in vitro prescreen correlative of activity in the in vivo Tg.AC assay. Here we describe the development of a prescreen based on correct response to 24 compounds tested previously in Tg.AC mice. The in vitro prescreens, chosen to reflect molecular pathways possibly involved in Tg.AC papilloma formation, consisted of a zeta-globin promoter-luciferase construct stably expressed in K562 cells (Zeta-Luc) and three of the stress-response element-chloramphenicol acetyltransferase (CAT) fusion constructs stably expressed in HepG2 cells that are part of the CAT-Tox (L)iver assay. The stress response elements chosen were the c-fos promoter, the gadd153 promoter, and p53 response element repeats. Of the four assays, the gadd153-CAT assay showed the strongest concordance with activity in the Tg.AC assay, correctly classifying 78% of Tg.AC positive and 83% of Tg.AC negative compounds. The correlation was further improved by adding the Zeta-Luc assay as a second-stage screen. These cell-based assays will be used in a novel approach to selecting candidate compounds that challenge the specificity of the Tg.AC assay toward pharmaceuticals. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Thompson, K L AU - Rosenzweig, B A AU - Tsong, Y AU - Sistare, F D AD - Division of Applied Pharmacology Research, OTR/OPS, Center for Drug Evaluation and Research, Food & Drug Administration, Laurel, Maryland 20708, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 43 EP - 53 VL - 57 IS - 1 SN - 1096-6080, 1096-6080 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DDIT3 protein, human KW - DNA-Binding Proteins KW - Ddit3 protein, mouse KW - Transcription Factors KW - Transcription Factor CHOP KW - 147336-12-7 KW - Globins KW - 9004-22-2 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Plasmids -- genetics KW - Humans KW - Globins -- genetics KW - DNA-Binding Proteins -- genetics KW - Genes, fos -- genetics KW - Mice KW - Mice, Transgenic KW - Transcription Factors -- genetics KW - Mutagenicity Tests KW - Transfection KW - DNA -- genetics KW - Genes, p53 -- genetics KW - Cell Line KW - Genes, Reporter -- genetics KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72221633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Evaluation+of+in+vitro+reporter+gene+induction+assays+for+use+in+a+rapid+prescreen+for+compound+selection+to+test+specificity+in+the+Tg.AC+mouse+short-term+carcinogenicity+assay.&rft.au=Thompson%2C+K+L%3BRosenzweig%2C+B+A%3BTsong%2C+Y%3BSistare%2C+F+D&rft.aulast=Thompson&rft.aufirst=K&rft.date=2000-09-01&rft.volume=57&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-13 N1 - Date created - 2000-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. AN - 71749611; 10942736 AB - The present study investigates whether reactive oxygen species (ROS) are involved in p53 activation, and if they are, which species is responsible for the activation. Our hypothesis is that hydroxyl radical (.OH) functions as a messenger for the activation of this tumor suppressor protein. Human lung epithelial cells (A549) were used to test this hypothesis. Cr(VI) was employed as the source of ROS due to its ability to generate a whole spectrum of ROS inside the cell. Cr(VI) is able to activate p53 by increasing the protein levels and enhancing both the DNA binding activity and transactivation ability of the protein. Increased cellular levels of superoxide radicals (O(2)(-).), hydrogen peroxide (H(2)O(2)), and.OH radicals were detected on the addition of Cr(VI) to the cells. Superoxide dismutase, by enhancing the production of H(2)O(2) from O(2)(-). radicals, increased p53 activity. Catalase, an H(2)O(2) scavenger, eliminated.OH radical generation and inhibited p53 activation. Sodium formate and aspirin,.OH radical scavengers, also suppressed p53 activation. Deferoxamine, a metal chelator, inhibited p53 activation by chelating Cr(V) to make it incapable of generating radicals from H(2)O(2). NADPH, which accelerated the one-electron reduction of Cr(VI) to Cr(V) and increased.OH radical generation, dramatically enhanced p53 activation. Thus.OH radical generated from Cr(VI) reduction in A549 cells is responsible for Cr(VI)-induced p53 activation. JF - American journal of physiology. Cell physiology AU - Wang, S AU - Leonard, S S AU - Ye, J AU - Ding, M AU - Shi, X AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown 26505, West Virginia, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - C868 EP - C875 VL - 279 IS - 3 SN - 0363-6143, 0363-6143 KW - Carcinogens, Environmental KW - 0 KW - Free Radicals KW - Tumor Suppressor Protein p53 KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Hydroxyl Radical KW - 3352-57-6 KW - Index Medicus KW - Oxygen Consumption KW - Dose-Response Relationship, Drug KW - Humans KW - Time Factors KW - Free Radicals -- metabolism KW - Cell Line KW - Tumor Suppressor Protein p53 -- physiology KW - Second Messenger Systems -- physiology KW - Hydroxyl Radical -- metabolism KW - Chromium -- pharmacology KW - Carcinogens, Environmental -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71749611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Cell+physiology&rft.atitle=The+role+of+hydroxyl+radical+as+a+messenger+in+Cr%28VI%29-induced+p53+activation.&rft.au=Wang%2C+S%3BLeonard%2C+S+S%3BYe%2C+J%3BDing%2C+M%3BShi%2C+X&rft.aulast=Wang&rft.aufirst=S&rft.date=2000-09-01&rft.volume=279&rft.issue=3&rft.spage=C868&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Cell+physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-14 N1 - Date created - 2000-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage. AN - 70602169; 11085318 AB - Methamphetamine (METH) is a neurotoxic psychostimulant that produces catecholaminergic brain damage by producing oxidative stress and free radical generation. The role of oxygen and nitrogen radicals is well documented as a cause of METH-induced neurotoxic damage. In this study, we have obtained evidence that METH-induced neurotoxicity is the resultant of interaction between oxygen and nitrogen radicals, and it is mediated by the production of peroxynitrite. We have also assessed the effects of inhibitors of neuronal nitric oxide synthase (nNOS) as well as scavenger of nitric oxide and a peroxynitrite decomposition catalyst. Significant protective effects were observed with the inhibitor of nNOS, 7-nitroindazole (7-NI), as well as by the selective peroxynitrite scavenger or decomposition catalyst, 5,10,15,20-tetrakis(2,4,6-trimethyl-3,5-sulfonatophenyl)porphyrinato iron III (FeTPPS). However, the use of a nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO), did not provide any significant protection against METH-induced hyperthermia or peroxynitrite generation and the resulting dopaminergic neurotoxicity. In particular, treatment with FeTPPS completely prevented METH-induced hyperthermia, peroxynitrite production, and METH-induced dopaminergic depletion. Together, these data demonstrate that METH-induced dopaminergic neurotoxicity is mediated by the generation of peroxynitrite, which can be selectively protected by nNOS inhibitors or peroxynitrite scavenger or decomposition catalysts. JF - Annals of the New York Academy of Sciences AU - Imam, S Z AU - Islam, F AU - Itzhak, Y AU - Slikker, W AU - Ali, S F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 157 EP - 171 VL - 914 SN - 0077-8923, 0077-8923 KW - Cyclic N-Oxides KW - 0 KW - Dopamine Uptake Inhibitors KW - Free Radical Scavengers KW - Imidazoles KW - Indazoles KW - Neuroprotective Agents KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Peroxynitrous Acid KW - 14691-52-2 KW - 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide KW - 18390-00-6 KW - Nitric Oxide KW - 31C4KY9ESH KW - Tyrosine KW - 42HK56048U KW - Methamphetamine KW - 44RAL3456C KW - 7-nitroindazole KW - UX0N37CMVH KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Administration Schedule KW - Drug Interactions KW - Imidazoles -- pharmacology KW - Corpus Striatum -- metabolism KW - Disease Models, Animal KW - Mice KW - Indazoles -- therapeutic use KW - Homovanillic Acid -- metabolism KW - Models, Biological KW - Electrochemistry -- methods KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Mice, Inbred C57BL KW - Chromatography, High Pressure Liquid -- methods KW - Cyclic N-Oxides -- pharmacology KW - Corpus Striatum -- drug effects KW - Tyrosine -- metabolism KW - Neuroprotective Agents -- therapeutic use KW - Male KW - Free Radical Scavengers -- pharmacology KW - Peroxynitrous Acid -- metabolism KW - Dopamine Uptake Inhibitors -- toxicity KW - Methamphetamine -- administration & dosage KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Neurotoxicity Syndromes -- prevention & control KW - Neurotoxicity Syndromes -- etiology KW - Nitric Oxide -- metabolism KW - Dopamine -- metabolism KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Prevention+of+dopaminergic+neurotoxicity+by+targeting+nitric+oxide+and+peroxynitrite%3A+implications+for+the+prevention+of+methamphetamine-induced+neurotoxic+damage.&rft.au=Imam%2C+S+Z%3BIslam%2C+F%3BItzhak%2C+Y%3BSlikker%2C+W%3BAli%2C+S+F&rft.aulast=Imam&rft.aufirst=S&rft.date=2000-09-01&rft.volume=914&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age as a susceptibility factor in the striatal dopaminergic neurotoxicity observed in the mouse following substituted amphetamine exposure. AN - 70602165; 11085321 AB - A number of substituted amphetamines, including methamphetamine (METH) are considered dopaminergic neurotoxicants. METH causes long-term depletions of striatal dopamine (DA) and its metabolites (DOPAC and HVA) that are accompanied by other changes indicative of nerve terminal degeneration. These include argyrophilia as detected by silver degeneration stains and an elevation in glial fibrillary acidic protein (GFAP), a marker of reactive gliosis in response to injury, as well as a long-term decrease in tyrosine hydroxylase (TH) protein levels. The susceptibility to the dopaminergic neurotoxicity of METH and the other amphetamines can be affected by a number of factors including age, gender, stress, and environment. Many of these susceptibility factors have been extensively investigated in the rat but less so in the mouse. As the availability of genetically altered mice continues to expand, this species is increasingly selected for study. Thus, in previous work we determined that stress, gender, and the environment can significantly impact the neurotoxicity of the amphetamines. Here we determined how age affects the striatal DA depletion and GFAP elevation induced by d-METH in C57BL/6 mice. Age was a significant determinant of the ability of a known neurotoxic regimen of d-METH (10 mg/kg x 4) to produce striatal DA depletion with one-month-old C57BL16 mice displaying minimal and nonpersistent depletion of DA or its metabolites while mice 12 months of age displayed large and persistent depletions of DA (87%), DOPAC (71%), and HVA (94%). Large elevations in striatal GFAP were induced in mice 2-23 months of age by d-METH, with lower dosages of d-METH being effective in the older mice. In contrast, the usual neurotoxic regimen of d-METH was minimally effective in inducing GFAP elevations (49% over control) in one-month-old mice, despite elevations in body temperature equivalent to those observed in older mice. Although increasing the dosage of d-METH (20 to 80 mg/kg) did increase the GFAP response (100% over control), it was still well below that usually exhibited at the usual neurotoxic dosage (300-400% over control) in fully mature mice. These data suggest maturity of striatal dopamine systems may be an essential element in the striatal damage induced by the neurotoxic amphetamines. JF - Annals of the New York Academy of Sciences AU - Miller, D B AU - O'Callaghan, J P AU - Ali, S F AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, NIOSH/CDC, Morgantown, West Virginia 26505, USA. dum6@cdc.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 194 EP - 207 VL - 914 SN - 0077-8923, 0077-8923 KW - Central Nervous System Stimulants KW - 0 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Sex Factors KW - Area Under Curve KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Disease Models, Animal KW - Mice KW - Homovanillic Acid -- metabolism KW - Models, Biological KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Mice, Inbred C57BL KW - Time Factors KW - Female KW - Male KW - Aging -- physiology KW - Methamphetamine -- administration & dosage KW - Neurotoxicity Syndromes -- etiology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Central Nervous System Stimulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Age+as+a+susceptibility+factor+in+the+striatal+dopaminergic+neurotoxicity+observed+in+the+mouse+following+substituted+amphetamine+exposure.&rft.au=Miller%2C+D+B%3BO%27Callaghan%2C+J+P%3BAli%2C+S+F&rft.aulast=Miller&rft.aufirst=D&rft.date=2000-09-01&rft.volume=914&rft.issue=&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of electrophysiological method to study interactions between ibogaine and cocaine. AN - 70600721; 11085337 AB - The psychoactive indole alkaloid, ibogaine (IBO), has been investigated for over a decade concerning its reported anti-addictive properties for opioids as well as psychomotor stimulants. The mechanism for the anti-addictive action of IBO is still unclear. IBO interactions with opioid, NMDA, nicotinic, adrenergic, and serotonergic receptor sites have been suggested. The involvement of the dopaminergic system in IBO action is well documented. Increased or decreased levels of dopamine (DA) in specific brain regions following IBO pretreatment have been seen concomitantly with increased or decreased motor activity after subsequent amphetamine or cocaine administration. In this report, in vivo electrophysiological measures were monitored in awake adult male rats in order to investigate alterations of the electrocorticogram (ECoG) resulting from interactions between IBO and cocaine (COC). Rats were implanted bilaterally with bipolar ECoG electrodes. They were either injected with saline, COC alone (20 mg/kg, i.p.) or IBO (50 mg/kg, i.p.) and COC 1 hr later. The concentrations of DA, 5-HT, and their metabolites DOPAC, HVA, and 5-HIAA were assessed in the caudate nucleus in separate groups of saline-, COC-, and IBO/COC-treated rats. An alpha1 power increase was observed within 10 min after COC injection, which lasted for less than 20 min. A desynchronization over alpha2 and both beta power bands was observed throughout the recording. In IBO/COC-treated rats, a significant increase in delta, theta, and alpha1 power occurred within 20 min after COC injection (p <0.05). This effect lasted for up to an hour. DA levels significantly increased after COC only and decreased after IBO administration. A further decrease in levels of DA was observed in IBO/COC-treated rats. DA turnover increased significantly after IBO alone but was not observed after IBO/COC treatment. The alterations in ECoG and neurotransmitter levels suggest a decreased response to COC following IBO pretreatment. JF - Annals of the New York Academy of Sciences AU - Binienda, Z AU - Beaudoin, M A AU - Thorn, B T AU - Sadovova, N AU - Skinner, R D AU - Slikker, W AU - Ali, S F AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA. zbinienda@nctr.fda.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 387 EP - 393 VL - 914 SN - 0077-8923, 0077-8923 KW - Dopamine Uptake Inhibitors KW - 0 KW - Excitatory Amino Acid Antagonists KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Serotonin KW - 333DO1RDJY KW - Ibogaine KW - 3S814I130U KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Brain Chemistry -- drug effects KW - Hydroxyindoleacetic Acid -- metabolism KW - Dopamine -- metabolism KW - Homovanillic Acid -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Serotonin -- metabolism KW - Time Factors KW - Wakefulness KW - Male KW - Cerebral Cortex -- drug effects KW - Electroencephalography -- methods KW - Cocaine -- pharmacology KW - Ibogaine -- pharmacology KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70600721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Application+of+electrophysiological+method+to+study+interactions+between+ibogaine+and+cocaine.&rft.au=Binienda%2C+Z%3BBeaudoin%2C+M+A%3BThorn%2C+B+T%3BSadovova%2C+N%3BSkinner%2C+R+D%3BSlikker%2C+W%3BAli%2C+S+F&rft.aulast=Binienda&rft.aufirst=Z&rft.date=2000-09-01&rft.volume=914&rft.issue=&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of chronic in utero exposure to cocaine on behavioral adaptability in rhesus monkey offspring when examined in adulthood. AN - 70599173; 11085340 JF - Annals of the New York Academy of Sciences AU - Paule, M G AU - Gillam, M P AU - Allen, R R AU - Chelonis, J J AD - Behavioral Toxicology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079-9502, USA. mpaule@nctr.fda.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 412 EP - 417 VL - 914 SN - 0077-8923, 0077-8923 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Macaca mulatta KW - Male KW - Female KW - Behavior, Animal KW - Pregnancy KW - Dopamine Uptake Inhibitors -- toxicity KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Adaptation, Psychological -- physiology KW - Cocaine -- toxicity KW - Adaptation, Psychological -- drug effects KW - Cocaine -- administration & dosage KW - Uterus -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70599173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Effects+of+chronic+in+utero+exposure+to+cocaine+on+behavioral+adaptability+in+rhesus+monkey+offspring+when+examined+in+adulthood.&rft.au=Paule%2C+M+G%3BGillam%2C+M+P%3BAllen%2C+R+R%3BChelonis%2C+J+J&rft.aulast=Paule&rft.aufirst=M&rft.date=2000-09-01&rft.volume=914&rft.issue=&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protein phosphorylation cascades associated with methamphetamine-induced glial activation. AN - 70598737; 11085325 AB - Reactive gliosis is the most prominent response to diverse forms of central nervous system (CNS) injury. The signaling events that mediate this characteristic response to neural injury are under intense investigation. Several studies have demonstrated the activation of phosphoproteins within the mitogen-activated protein kinase (MAPK) and Janus kinase (JAK) pathways following neural insult. These signaling pathways may be involved or responsible for the glial response following injury, by virtue of their ability to phosphorylate and dynamically regulate the activity of various transcription factors. This study sought to delineate, in vivo, the relative contribution of MAPK- and JAK-signaling components to reactive gliosis as measured by induction of glial-fibrillary acidic protein (GFAP), following chemical-induced neural damage. At time points (6, 24, and 48 h) following methamphetamine (METH, 10 mg/kg x 4, s.c.) administration, female C57BL/6J mice were sacrificed by focused microwave irradiation, a technique that preserves steady-state phosphorylation. Striatal (target) and nontarget (hippocampus) homogenates were assayed for METH-induced changes in markers of dopamine (DA) neuron integrity as well as differences in the levels of activated phosphoproteins. GFAP upregulation occurred as early as 6 h, reaching a threefold induction 48 h following METH exposure. Neurotoxicant-induced reductions in striatal levels of DA and tyrosine hydroxylase (TH) paralleled the temporal profile of GFAP induction. Blots of striatal homogenates, probed with phosphorylation-state specific antibodies, demonstrated significant changes in activated forms of extracellular-regulated kinase 1/2 (ERK 1/2), c-jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), MAPK/ERK kinase (MEK1/2), 70-kDa ribosomal S6 kinase (p70 S6), cAMP responsive element binding protein (CREB), and signal transducer and activator of transcription 3 (STAT3). MAPK-related phosphoproteins exhibited an activation profile that peaked at 6 h, remained significantly increased at 24, and fell to baseline levels 48 h following neurotoxicant treatment. The ribosomal S6 kinase was enhanced over 60% for all time points examined. Immunoreactivity profiles for the transcription factors CREB and STAT3 indicated maximal increases in phosphorylation occurring at 24 h, and measuring greater than 2- or 17-fold, respectively. Specific signaling events were found to occur with a time course suggestive of their involvement in the gliotic response. The toxicant-induced activation of these growth-associated signaling cascades suggests that these pathways could be obligatory for the triggering and/or persistence of reactive gliosis and may therefore serve as potential targets for modulation of glial response to neural damage. JF - Annals of the New York Academy of Sciences AU - Hebert, M A AU - O'Callaghan, J P AD - Department of Health & Human Services, Public Health Service, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505-2888, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 238 EP - 262 VL - 914 SN - 0077-8923, 0077-8923 KW - Central Nervous System Stimulants KW - 0 KW - Cyclic AMP Response Element-Binding Protein KW - Glial Fibrillary Acidic Protein KW - Proteins KW - Methamphetamine KW - 44RAL3456C KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Ribosomal Protein S6 Kinases, 70-kDa KW - EC 2.7.11.1 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 1 KW - MAP Kinase Kinase 4 KW - EC 2.7.12.2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Drug Administration Schedule KW - Glial Fibrillary Acidic Protein -- metabolism KW - Dopamine -- metabolism KW - Mice KW - Ribosomal Protein S6 Kinases, 70-kDa -- metabolism KW - Models, Biological KW - Phosphorylation -- drug effects KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - MAP Kinase Kinase 4 -- metabolism KW - Time Factors KW - Female KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Neuroglia -- metabolism KW - Methamphetamine -- administration & dosage KW - Gene Expression Regulation -- drug effects KW - Neuroglia -- drug effects KW - Central Nervous System Stimulants -- administration & dosage KW - Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70598737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Protein+phosphorylation+cascades+associated+with+methamphetamine-induced+glial+activation.&rft.au=Hebert%2C+M+A%3BO%27Callaghan%2C+J+P&rft.aulast=Hebert&rft.aufirst=M&rft.date=2000-09-01&rft.volume=914&rft.issue=&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - IL-4 receptor-directed cytotoxin for therapy of AIDS-associated KS tumors. AN - 70543893; 12937611 AB - AIDS-associated Kaposi's sarcoma (AIDS-KS) represents one of the most common malignancies associated with human immunodeficiency virus infection. To target effective therapeutic agents, we have discovered that AIDS-KS cells express high-affinity receptors for interleukin-4 (IL-4), a pleiotropic immune regulatory cytokine. Molecular studies have revealed that AIDS-KS cells express type II IL-4 receptors, in which IL-4 forms a productive complex with primary IL-4 binding protein (IL-4R beta, also known as IL-4R alpha) and a shared subunit between IL-4 and IL-13R systems (IL-13R alpha', also known as IL-13R alpha 1). A recombinant fusion protein composed of IL-4 and a mutated form of a powerful bacterial toxin called Pseudomonas exotoxin (PE)--the fusion protein is termed IL4(3837)-PE38KDEL or cpIL4-PE--was found to be highly and specifically cytotoxic to AIDS-KS cells in vitro. Normal human immune cells (e.g., resting T and B cells and monocytes) or endothelial cells, a possible precursor of AIDS-KS, expressed low numbers of IL-4R and showed little or no sensitivity to cpIL4-PE. Administration of cpIL4-PE in nude mice with established subcutaneously growing AIDS-KS tumors produced remarkable antitumor activity in a dose-dependent manner with the highest dose exhibiting complete responses without any visible toxicity. KS tumors produced metabolic changes including cachexia, hypoglycemia and lymphopenia, all of which were prevented by cpIL4-PE treatment. These studies indicate that cpIL4-PE is a promising experimental therapeutic agent for treatment of AIDS-KS. JF - Drug news & perspectives AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 395 EP - 402 VL - 13 IS - 7 SN - 0214-0934, 0214-0934 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70543893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+news+%26+perspectives&rft.atitle=IL-4+receptor-directed+cytotoxin+for+therapy+of+AIDS-associated+KS+tumors.&rft.au=Puri%2C+R+K&rft.aulast=Puri&rft.aufirst=R&rft.date=2000-09-01&rft.volume=13&rft.issue=7&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Drug+news+%26+perspectives&rft.issn=02140934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-11-07 N1 - Date created - 2003-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Restraint as a stressor in mice: against the dopaminergic neurotoxicity of D-MDMA, low body weight mitigates restraint-induced hypothermia and consequent neuroprotection. AN - 70530638; 10967304 AB - In experimental studies of stress, restraint of laboratory rodents, perceived as easy to apply and believed to be reproducible, is a commonly used manipulation. The restraint manipulation is utilized as a technique to characterize the physiological, cellular and molecular consequences of stress as well as a tool to understand the ways in which stress may interact with toxic substances. In previous work, we utilized restraint in an examination of the effect of stress on the striatal dopaminergic neurotoxicity engendered by a series of substituted amphetamines. Contrary to our expectations, and most likely due to its body temperature-reducing properties in the mouse, restraint provided total or near total protection against the neurotoxicity of these agents. During subsequent studies utilizing C57Bl6/J female mice of varying weights and ages the degree of temperature reduction and the associated ability to block (20-100%) the dopamine depletion associated with the neurotoxic amphetamine 3,4-methylendioxyamphetamine (D-MDMA, 20 mg/kg of mouse body weight, every 2 h, s.c., total of four doses) were found to vary considerably more than had been previously observed. An in-depth analysis of the role mouse weight plays in the temperature reduction induced by restraint indicates mouse weight is a primary determinant of hypothermia and subsequent neuroprotection. It suggests the induction of stress in rodents by restraint is a complex effect that may lead to unanticipated results. The restraint manipulation is not as straight-forward a procedure as is commonly believed. Our data indicate that consistent application of restraint may require an adjustment of the restrainer device to mouse body weight. JF - Brain research AU - Johnson, E A AU - Sharp, D S AU - Miller, D B AD - Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health/Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA. edj2@cdc.gov Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 107 EP - 118 VL - 875 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Dopamine Antagonists KW - 0 KW - Neurotoxins KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Aging -- physiology KW - Animals KW - Body Temperature -- drug effects KW - Corpus Striatum -- metabolism KW - Mice, Inbred C57BL KW - Corpus Striatum -- drug effects KW - Mice KW - Brain -- metabolism KW - Rectum -- physiology KW - Female KW - Stress, Physiological -- etiology KW - Restraint, Physical KW - 3,4-Methylenedioxyamphetamine -- poisoning KW - Hypothermia -- physiopathology KW - Dopamine Antagonists -- poisoning KW - Body Weight -- physiology KW - Neurotoxins -- pharmacology KW - Dopamine -- metabolism KW - Cytoprotection -- physiology KW - Hypothermia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70530638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Restraint+as+a+stressor+in+mice%3A+against+the+dopaminergic+neurotoxicity+of+D-MDMA%2C+low+body+weight+mitigates+restraint-induced+hypothermia+and+consequent+neuroprotection.&rft.au=Johnson%2C+E+A%3BSharp%2C+D+S%3BMiller%2C+D+B&rft.aulast=Johnson&rft.aufirst=E&rft.date=2000-09-01&rft.volume=875&rft.issue=1-2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-07 N1 - Date created - 2002-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Make Time To Listen, Take Time To Talk. 15+. AN - 62348313; ED450958 AB - Noting that parents and caregivers are vital to the healthy development and growth of children, this pamphlet discusses ways parents and caregivers can help children learn more about themselves and their environment in order to prevent violence. The pamphlet reminds parents to make time to listen to their children and take time to talk with them. Parents are encouraged to: (1) nurture their children; (2) model ways to control anger; (3) develop good communication with their children; (4) respect their children and teach them to respect others; (5) take interest in their child's education and development; (6) keep their child drug-free; and (7) help them develop peaceful solutions to conflict. The pamphlet also suggests ways that parents can prevent their child from becoming a bully or the victim of a bully and discusses reasons why youth join gangs. Finally, the pamphlet delineates rules for spending quality time together. (KB) Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 7 PB - Knowledge Exchange Network, P.O. Box 42490, Washington, DC 20015. KW - Relationship Quality KW - ERIC, Resources in Education (RIE) KW - Parents KW - Parent Education KW - Parent Materials KW - Parent Child Relationship KW - Child Rearing KW - Children KW - Role Models KW - Bullying KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62348313?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Also produced by WJLA, ABC Channel 7, Washington, N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Reflections on hexavalent chromium; health hazards of an industrial heavyweight AN - 52221372; 2001-045983 JF - Environmental Health Perspectives AU - Pellerin, Cheryl AU - Brooker, Susan M Y1 - 2000/09// PY - 2000 DA - September 2000 SP - A402 EP - A407 PB - U. S. Department of Health and Human Services, Public Health Service, Research Triangle Park, NC VL - 108 IS - 9 SN - 0091-6765, 0091-6765 KW - hazardous waste KW - concentration KW - toxic materials KW - medical geology KW - pollutants KW - effluents KW - damage KW - pollution KW - bioavailability KW - environmental effects KW - biota KW - human ecology KW - bioaccumulation KW - hexavalent chromium KW - toxicity KW - metals KW - industrial waste KW - chromium KW - public health KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52221372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Reflections+on+hexavalent+chromium%3B+health+hazards+of+an+industrial+heavyweight&rft.au=Pellerin%2C+Cheryl%3BBrooker%2C+Susan+M&rft.aulast=Pellerin&rft.aufirst=Cheryl&rft.date=2000-09-01&rft.volume=108&rft.issue=9&rft.spage=A402&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ L2 - http://www.jstor.org/journals/00916765.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - PubXState - NC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bioaccumulation; bioavailability; biota; chromium; concentration; damage; effluents; environmental effects; hazardous waste; hexavalent chromium; human ecology; industrial waste; medical geology; metals; pollutants; pollution; public health; toxic materials; toxicity ER - TY - RPRT T1 - Toxicological profile for chromium AN - 52189592; 2001-061613 JF - Toxicological profile for chromium AU - Wilbur, Sharon AU - Ingerman, Lisa AU - Citra, Mario AU - Osier, Mark AU - Wohlers, Dave Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 419 KW - water KW - soils KW - toxic materials KW - monitoring KW - medical geology KW - pollutants KW - pollution KW - bioavailability KW - bibliography KW - human ecology KW - toxicity KW - transport KW - metals KW - chemical properties KW - air KW - waste disposal KW - kinetics KW - geochemistry KW - chromium KW - public health KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52189592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilbur%2C+Sharon%3BIngerman%2C+Lisa%3BCitra%2C+Mario%3BOsier%2C+Mark%3BWohlers%2C+Dave&rft.aulast=Wilbur&rft.aufirst=Sharon&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Toxicological+profile+for+chromium&rft.title=Toxicological+profile+for+chromium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 1071 N1 - Availability - U. S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States N1 - Document feature - illus. incl. 20 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2012-06-07 ER - TY - RPRT T1 - Toxicological profile for toluene AN - 52186707; 2001-061612 JF - Toxicological profile for toluene AU - Dorsey, Alfred AU - McClure, Peter R AU - McDonald, A Rosa AU - Singh, Mona Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 312 KW - water KW - soils KW - toxic materials KW - monitoring KW - medical geology KW - toluene KW - pollutants KW - pollution KW - bioavailability KW - environmental effects KW - bibliography KW - human ecology KW - organic compounds KW - toxicity KW - sediments KW - hydrocarbons KW - chemical properties KW - air KW - kinetics KW - geochemistry KW - aromatic hydrocarbons KW - public health KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52186707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dorsey%2C+Alfred%3BMcClure%2C+Peter+R%3BMcDonald%2C+A+Rosa%3BSingh%2C+Mona&rft.aulast=Dorsey&rft.aufirst=Alfred&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Toxicological+profile+for+toluene&rft.title=Toxicological+profile+for+toluene&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 1426 N1 - Availability - U. S. Department of Heath and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States N1 - Document feature - illus. incl. 16 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2012-06-07 ER - TY - RPRT T1 - Draft toxicological profile for beryllium AN - 52165229; 2002-001504 JF - Draft toxicological profile for beryllium AU - Smith, Cassandra AU - Ingerman, Lisa AU - Amata, Richard Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 239 KW - water KW - soils KW - concentration KW - alkaline earth metals KW - toxic materials KW - monitoring KW - degradation KW - pollutants KW - pollution KW - bioavailability KW - bibliography KW - toxicity KW - transport KW - metals KW - sediments KW - chemical properties KW - ecology KW - air KW - waste disposal KW - geochemistry KW - beryllium KW - public health KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52165229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Smith%2C+Cassandra%3BIngerman%2C+Lisa%3BAmata%2C+Richard&rft.aulast=Smith&rft.aufirst=Cassandra&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Draft+toxicological+profile+for+beryllium&rft.title=Draft+toxicological+profile+for+beryllium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 527 N1 - Availability - U. S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States N1 - Document feature - illus. incl. 19 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Elevated oxidative stress in skin of B6C3F1 mice affects dermal exposure to metal working fluid AN - 18222712; 5292459 AB - Metal working fluids (MWFs) are widely used in industry for metal cutting, drilling, shaping, lubricating, and milling. Potential for dermal exposure to MWFs exists for a large number of men and women via aerosols and splashing during the machining operations. It has been reported earlier that occupational exposure to MWFs causes allergic and irritant contact dermatitis. Previously, we showed that dermal exposure of female and male B6C3F1 mice to 5% MWFs for 3 months resulted in accumulation of mast cells and elevation of histamine in the skin. Topical exposure to MWF also resulted in elevated oxidative stress in the liver of both sexes and the testes in males. The goal of this study was to evaluate the interaction between oxidative stress in the skin and topical application of MWF. Oxidative stress in skin of B6C3F1 mice of both sexes was generated by intradermal injection of the hydrogen peroxide (H sub(2)O sub(2))-producing enzyme, glucose oxidase with polyethylene glycol (GOD + PEG). In mice given GOD + PEG, topical treatment with MWF (200 mu l, 30%, for 1, 3, or 7 days) resulted in a mixed inflammatory cell response, accumulation of peroxidative products, and reduction of GSH content in the skin. Such changes were not observed with MWF treatment alone. These data indicate that oxidative stress can enhance dermal inflammation caused by occupational exposure to MWF. JF - Toxicology and Industrial Health AU - Shvedova, A A AU - Kisin, E AU - Kisin, J AU - Castranova, V AU - Kommineni, C AD - Health Effects Laboratory Division, Pathology and Physiology Research Branch, NIOSH m/s 2015, 1095 Willowdale Road, Morgantown, WV 26505, USA, ats1@cdc.gov Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 267 EP - 276 VL - 16 IS - 7-8 SN - 0748-2337, 0748-2337 KW - mice KW - metal working fluids KW - Toxicology Abstracts KW - Glucose oxidase KW - Skin KW - Oxidative stress KW - Hydrogen peroxide KW - Polyethylene glycol KW - Occupational exposure KW - Inflammation KW - X 24151:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18222712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Elevated+oxidative+stress+in+skin+of+B6C3F1+mice+affects+dermal+exposure+to+metal+working+fluid&rft.au=Shvedova%2C+A+A%3BKisin%2C+E%3BKisin%2C+J%3BCastranova%2C+V%3BKommineni%2C+C&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2000-09-01&rft.volume=16&rft.issue=7-8&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Polyethylene glycol; Occupational exposure; Hydrogen peroxide; Glucose oxidase; Skin; Oxidative stress; Inflammation ER - TY - JOUR T1 - Effects of metal working fluids on B6C3F1 mouse skin AN - 17861640; 5109547 AB - Over 10 million workers in the United States are exposed to metal working fluids (MWFs) through dermal contact and/or inhalation of aerosolized fluids. The objective of this study was to elucidate the response of skin to dermal exposure to MWFs. Four- to six-week-old B6C3F1 mice of both sexes were divided into eight groups (n=5/group) and exposed to 200 mu l of 0%, 5% (pH 7 and 9.7) and 100% (pH 10.4), unused MWFs/H sub(2)O by topical application to the unshaven back (cervical to sacral region), twice a week for 6 weeks. Skin-mast cell number in females of most treated groups and of two male groups (100% and 5%, pH 7) were significantly higher than the control groups. Eventhough both males and females (treated with 100% MWF/H sub(2)O) showed an increase in the skin-histamine levels (38% and 41%, respectively), this increase was significant in females only (ANOVA, P less than or equal to 0.05). Dermal exposure to 100% MWFs increased liver weight significantly in both sexes. Ulcers and associated inflammation were seen in the skin of mice treated with 100% unused MWFs and sacrificed at 6 weeks, but not in the recovery groups. Hypertrophy of the sebaceous gland epithelium is present in all mice treated for 6 weeks and sacrificed immediately. However, only the mice treated with 100% MWF retained the hypertrophy of this epithelium after a 6-week recovery period. In conclusion, dermal exposure to unused semi-synthetic MWF penetrates the normal skin, induces mast cell accumulation in the skin, produces hypertrophy of the sebaceous glands, and may affect females more than males. JF - Toxicology and Industrial Health AU - Al-Humadi, N H AU - Battelli, L AU - Willard, P A AU - Schwegler-Berry, D AU - Castranova, V AU - Kommineni, C AD - HELD, NIOSH 1095 Willowdale Road, Morgantown, WV 26505, USA, cdk2@cdc.gov Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 203 EP - 210 VL - 16 IS - 6 SN - 0748-2337, 0748-2337 KW - mice KW - Toxicology Abstracts KW - Hypertrophy KW - Skin KW - Epithelium KW - Metal-working fluids KW - Sebaceous gland KW - Occupational exposure KW - X 24151:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17861640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Effects+of+metal+working+fluids+on+B6C3F1+mouse+skin&rft.au=Al-Humadi%2C+N+H%3BBattelli%2C+L%3BWillard%2C+P+A%3BSchwegler-Berry%2C+D%3BCastranova%2C+V%3BKommineni%2C+C&rft.aulast=Al-Humadi&rft.aufirst=N&rft.date=2000-09-01&rft.volume=16&rft.issue=6&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Metal-working fluids; Occupational exposure; Epithelium; Hypertrophy; Sebaceous gland ER - TY - JOUR T1 - Structural parameters and floristic composition of one hectare of terra firme dense forest in the Uatuma River Valley, Amazonia, Brazil TT - Composicao floristica e parametros estruturais de um hectare de floresta densa de terra firme no Rio Uatuma, Amazonia, Brasil AN - 17803034; 4849009 AB - An area of terra firme dense forest in the Uatuma River basin, county of Sao Sebastiao, Amazonas, Brazil was surveyed. The floristic composition, richness of species, and structural parameters of the vegetation were studied. A survey of one hectare was carried out by using a transect of 10 x 1000 m, divided in 20 plots of 10 x 50 m, where every individual with a diameter at breast height (DBH) greater than or equal to 10 cm was measured, including trees, lianas and palms. The understory stratum was studied by using small plots of 2 x 2 m, according to the size category criterion. Structural parameters were assessed through the Importance Value Index (IVI) of the species, the number of individuals per class of diameter, and the biological spectrum of the understory stratum. A total of 741 individuals (with DBH greater than or equal to 10 cm) were recorded, distributed in 46 families, 118 genera and 145 species. Families with the greatest number of species were Leguminosae sensu lato (33), Myrtaceae (8) and Lauraceae (7), representing 33% of the total recorded individuals. Protium apiculatum and Eschweilera coriacea were the species with higher IVI (22.4 and 17.6 respectively), representing 15% of the total IVI. These two species presented more uniform distributions and greatest number of individuals in the area. The understory stratum was composed of a high proportion (28.7%) of individuals, corresponding to 25.4% of total species, which have their whole life circle in this stratum. Therefore, these species should not be included as part of forest regeneration, as practiced by many projects of forest management. JF - Acta Amazonica AU - Do Amaral, IL AU - Matos, FDA AU - Lima, J AD - Instituto Nacional de Pesquisas da Amazonia (INPA), Coordenacao de Pesquisas em Botanica (CPBO), Av. Andre Araujo, 2936, Petropolis, CEP 69.083-000, Manaus, AM. Brasil, iamaral@inpa.gov.br Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 377 EP - 392 VL - 30 IS - 3 SN - 0044-5967, 0044-5967 KW - Brazil KW - Ecology Abstracts KW - Vegetation patterns KW - Tropical environment KW - Forests KW - D 04126:Tropical forests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17803034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Amazonica&rft.atitle=Structural+parameters+and+floristic+composition+of+one+hectare+of+terra+firme+dense+forest+in+the+Uatuma+River+Valley%2C+Amazonia%2C+Brazil&rft.au=Do+Amaral%2C+IL%3BMatos%2C+FDA%3BLima%2C+J&rft.aulast=Do+Amaral&rft.aufirst=IL&rft.date=2000-09-01&rft.volume=30&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Acta+Amazonica&rft.issn=00445967&rft_id=info:doi/ LA - Portuguese DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Forests; Tropical environment; Vegetation patterns ER - TY - CONF T1 - Lead and cancer in humans: Where are we now? AN - 17688037; 4773200 AB - Lead is only weakly mutagenic, but in vitro it inhibits DNA repair and acts synergistically with other mutagens. Lead acetate administered orally, cutaneously, or intraperitoneally causes kidney cancer, brain cancer (gliomas), and lung cancer in rodents, and acts synergistically with other carcinogens. Most cytogenetic studies of exposed workers have shown increases in chromosome aberrations or sister chromatid exchange, including some studies with positive-exposure response trends. There are eight studies of cancer mortality or incidence among highly exposed workers; most are cohort studies of lead smelter or battery workers exposed decades ago. We reviewed the epidemologic studies with regard to cancer. These studies provide some evidence of increased risk of lung cancer (RR = 1.30, 1.15-1.46, 675 observed deaths) and stomach cancer (combined RR = 1.34, 1.14-1.57, 181 observed). However, the lung cancer findings are not consistent across studies, and confounding by arsenic may affect the study with the highest lung cancer RR. Exclusion of that study yields a combined lung cancer RR of 1.14 (1.04-1.73). There is little evidence of increased risk of kidney cancer (combined RR = 1.01, 0.72-1.42, 40 observed) or brain cancer (combined RR = 1.06, 0.81-1.40, 69 observed). However, two studies show a two-fold increase in kidney cancer, and one study shows a significant excess of gliomas. IARC classified lead as a "possible human carcinogen" based on sufficient animal data and insufficient human data in 1987. Six of the eight studies cited above have been published since 1987. Overall, there is only weak evidence associating lead with cancer; the most likely candidates are lung cancer, stomach cancer, and gliomas. JF - American Journal of Industrial Medicine AU - Steenland, K AU - Boffetta, P Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 295 EP - 299 PB - John Wiley & Sons, Inc., 605 Third Ave. New York NY 10158 USA, [URL:http://interscience.wiley.com/jpages/0271-3586/] VL - 38 IS - 3 KW - man KW - DNA repair KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - Cancer KW - Lead KW - Reviews KW - H 11000:Diseases/Injuries/Trauma KW - X 24166:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17688037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Lead+and+cancer+in+humans%3A+Where+are+we+now%3F&rft.au=Steenland%2C+K%3BBoffetta%2C+P&rft.aulast=Steenland&rft.aufirst=K&rft.date=2000-09-01&rft.volume=38&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Improved Identification and Differentiation of Varicella-Zoster Virus (VZV) Wild-Type Strains and an Attenuated Varicella Vaccine Strain Using a VZV Open Reading Frame 62-Based PCR AN - 17635369; 4774971 AB - A new method was developed to identify and differentiate varicella-zoster virus (VZV) wild-type strains from the attenuated varicella Oka vaccine strain. The PCR technique was used to amplify a VZV open reading frame (ORF) 62 region. A single specific amplicon of 268 bp was obtained from 71 VZV clinical isolates and several laboratory strains. Subsequent digestion of the VZV ORF 62 amplicons with SmaI enabled accurate strain differentiation (three SmaI sites were present in amplicons of vaccine strain VZV, compared with two enzyme cleavage sites for all other VZV strains tested). This method accurately differentiated the Oka vaccine strain from wild-type VZV strains circulating in countries representing all six populated continents. Moreover, the assay more reliably distinguished wild-type Japanese strains from the vaccine strain than did previously described methods. JF - Journal of Clinical Microbiology AU - Loparev, V N AU - Argaw, T AU - Krause, PR AU - Takayama, Michiko AU - Schmid, D S AD - Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA, vn10@cdc.gov Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 3156 EP - 3160 VL - 38 IS - 9 SN - 0095-1137, 0095-1137 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Differentiation KW - Varicella-zoster virus KW - Polymerase chain reaction KW - Assays KW - Vaccines KW - A 01114:Viruses KW - V 22022:Virus assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17635369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Improved+Identification+and+Differentiation+of+Varicella-Zoster+Virus+%28VZV%29+Wild-Type+Strains+and+an+Attenuated+Varicella+Vaccine+Strain+Using+a+VZV+Open+Reading+Frame+62-Based+PCR&rft.au=Loparev%2C+V+N%3BArgaw%2C+T%3BKrause%2C+PR%3BTakayama%2C+Michiko%3BSchmid%2C+D+S&rft.aulast=Loparev&rft.aufirst=V&rft.date=2000-09-01&rft.volume=38&rft.issue=9&rft.spage=3156&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Varicella-zoster virus; Differentiation; Assays; Vaccines; Polymerase chain reaction ER - TY - JOUR T1 - Characterization of gyrA mutations associated with fluoroquinolone resistance in Campylobacter coli by DNA sequence analysis and MAMA PCR AN - 17614191; 4754229 AB - Increasing numbers of fluoroquinolone-resistant Campylobacter coli isolates received at the Minnesota State Public Health Laboratory and at the Centers for Disease Control and Prevention have been a cause for concern. The gyrA quinolone resistance-determining regions of several fluoroquinolone-resistant isolates were sequenced to examine the mechanism of resistance. Ciprofloxacin-resistant C. coli isolates examined by DNA sequencing had a Thr-86 to Ile (ACT arrow right ATT) gyrA mutation, leading to resistance to fluoroquinolone antibiotics. A mismatch amplification mutation assay polymerase chain reaction protocol was developed to detect this gyrA mutation. JF - FEMS Microbiology Letters AU - Zirnstein, G AU - Helsel, L AU - Swaminathan, B AU - Besser, J AD - National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Mail Stop C03, 1600 Clifton Road, Atlanta, GA 30333, USA, gaz3@cdc.gov Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 1 EP - 7 PB - Elsevier VL - 190 IS - 1 SN - 0378-1097, 0378-1097 KW - ciprofloxacin KW - gyrA gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Ciprofloxacin KW - Fluoroquinolones KW - Nucleotide sequence KW - Drug resistance KW - DNA topoisomerase KW - Campylobacter coli KW - Antibiotic resistance KW - G 07320:Bacterial genetics KW - J 02814:Drug resistance KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17614191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Characterization+of+gyrA+mutations+associated+with+fluoroquinolone+resistance+in+Campylobacter+coli+by+DNA+sequence+analysis+and+MAMA+PCR&rft.au=Zirnstein%2C+G%3BHelsel%2C+L%3BSwaminathan%2C+B%3BBesser%2C+J&rft.aulast=Zirnstein&rft.aufirst=G&rft.date=2000-09-01&rft.volume=190&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1016%2FS0378-1097%2800%2900306-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Campylobacter coli; Fluoroquinolones; Drug resistance; Nucleotide sequence; Ciprofloxacin; DNA topoisomerase; Antibiotic resistance DO - http://dx.doi.org/10.1016/S0378-1097(00)00306-2 ER - TY - JOUR T1 - Toxicological Profile for Toluene (Update) AN - 14557139; 10595383 AB - Available information on the environmental fate and toxicokinetics of exposure to toluene is revised. Health impacts considered by dermal, oral, and inhalation exposure routes include systemic, immunological and lymphoreticular, neurological, reproductive, developmental, genotoxic, and carcinogenic effects. Absorption, distribution, and metabolism are explained, as are mechanisms of action, biomarkers of exposure and effect, populations that are unusually susceptible, and methods for reducing toxic effects. The potential for human exposure is gauged in terms of releases to the environment, levels monitored or estimated in the environment, and general population and occupational exposures. JF - HHS Report: Toxicological Profile for Toluene (Update) Y1 - 2000/09// PY - 2000 DA - Sep 2000 PB - U.S. Department of Health and Human Services, The Boulevard Kidlington Oxford OX5 1GB KW - Environment Abstracts KW - TOLUENE KW - PATHOLOGY, HUMAN KW - POLLUTANT FATE KW - PUBLIC HEALTH KW - PATHOLOGY, ANIMALLABORATORY KW - HEALTH SAFETY, OCCUPATIONAL KW - DOSE RESPONSE PROFILES KW - CARCINOGENIC MECHANISMS KW - LITERATURE SURVEYS KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14557139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HHS+Report%3A+Toxicological+Profile+for+Toluene+%28Update%29&rft.atitle=Toxicological+Profile+for+Toluene+%28Update%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=HHS+Report%3A+Toxicological+Profile+for+Toluene+%28Update%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Document feature - |n 2 |t diagrams N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - HEALTH SAFETY, OCCUPATIONAL; DOSE RESPONSE PROFILES; CARCINOGENIC MECHANISMS; PATHOLOGY, HUMAN; TOLUENE; POLLUTANT FATE; PUBLIC HEALTH; PATHOLOGY, ANIMALLABORATORY; LITERATURE SURVEYS ER - TY - JOUR T1 - Toxicological Profile for Arsenic (Update) AN - 14556823; 10595276 AB - Updated data on the environmental fate and toxicology of arsenic are compiled. Health effects are delineated by oral, inhalation, and dermal exposure routes and cover systemic, immunological and lymphoreticular, neurological, reproductive, developmental, genotoxic, and carcinogenic effects. Absorption, distribution, metabolism, and other facets of toxicokinetics are explained, as are mechanisms of action, relevance to public health, biomarkers of exposure and effect, and methods for reducing toxic effects. The potential for human exposure is gauged in terms of releases to the environment, levels monitored or estimated in the environment, and general population and occupational exposures. JF - HHS Report: Toxicological Profile for Arsenic (Update) Y1 - 2000/09// PY - 2000 DA - Sep 2000 PB - US Department of Health and Human Services, The Boulevard Kidlington Oxford OX5 1GB KW - Environment Abstracts KW - METAL CONCENTRATIONS KW - PATHOLOGY, HUMAN KW - POLLUTANT FATE KW - PUBLIC HEALTH KW - PATHOLOGY, ANIMALLABORATORY KW - HEALTH SAFETY, OCCUPATIONAL KW - METAL CONTAMINATION KW - DOSE RESPONSE PROFILES KW - CARCINOGENIC MECHANISMS KW - ARSENIC KW - LITERATURE SURVEYS KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14556823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HHS+Report%3A+Toxicological+Profile+for+Arsenic+%28Update%29&rft.atitle=Toxicological+Profile+for+Arsenic+%28Update%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=HHS+Report%3A+Toxicological+Profile+for+Arsenic+%28Update%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Document feature - |n 4 |t diagrams N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - METAL CONTAMINATION; HEALTH SAFETY, OCCUPATIONAL; METAL CONCENTRATIONS; DOSE RESPONSE PROFILES; CARCINOGENIC MECHANISMS; PATHOLOGY, HUMAN; ARSENIC; POLLUTANT FATE; PUBLIC HEALTH; PATHOLOGY, ANIMALLABORATORY; LITERATURE SURVEYS ER - TY - JOUR T1 - Toxicological Profile for Methylene Chloride (Update) AN - 14556799; 10595384 AB - Toxicological and public health data concerning exposure to methylene chloride are updated. Health effects are outlined by dermal, oral, and inhalation exposure routes, and encompass systemic, immunological and lymphoreticular, neurological, reproductive, developmental, genotoxic, and carcinogenic effects. Absorption, distribution, metabolism, and other facets of toxicokinetics are covered, as are mechanisms of action, biomarkers of exposure and effect, and methods for reducing toxic effects. The potential for human exposure is discussed in terms of releases to the environment, environmental fate, levels monitored or estimated in the environment, and general population and occupational exposures. JF - HHS Report: Toxicological Profile for Methylene Chloride (Update) Y1 - 2000/09// PY - 2000 DA - Sep 2000 PB - U.S. Department of Health and Human Services, The Boulevard Kidlington Oxford OX5 1GB KW - Environment Abstracts KW - SOLVENTS KW - PATHOLOGY, HUMAN KW - POLLUTANT FATE KW - CHLORIDES KW - PUBLIC HEALTH KW - PATHOLOGY, ANIMALLABORATORY KW - HEALTH SAFETY, OCCUPATIONAL KW - DOSE RESPONSE PROFILES KW - CARCINOGENIC MECHANISMS KW - LITERATURE SURVEYS KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14556799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HHS+Report%3A+Toxicological+Profile+for+Methylene+Chloride+%28Update%29&rft.atitle=Toxicological+Profile+for+Methylene+Chloride+%28Update%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=HHS+Report%3A+Toxicological+Profile+for+Methylene+Chloride+%28Update%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Document feature - |n 2 |t diagrams N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - SOLVENTS; HEALTH SAFETY, OCCUPATIONAL; DOSE RESPONSE PROFILES; CARCINOGENIC MECHANISMS; PATHOLOGY, HUMAN; CHLORIDES; POLLUTANT FATE; PUBLIC HEALTH; PATHOLOGY, ANIMALLABORATORY; LITERATURE SURVEYS ER - TY - JOUR T1 - Toxicological profile for Manganese (Update) AN - 14555791; 10595381 AB - Revised data concerning the public health implications of exposure to manganese are compiled. Health effects are delineated in terms of oral, dermal, and inhalation exposure routes, and cover systemic, immunological and lymphoreticular, neurological, reproductive, developmental, genotoxic, and carcinogenic effects. Absorption, distribution, metabolism, and other facets of toxicokinetics are detailed, as are mechanisms of action, biomarkers of exposure and effect, and methods for reducing toxic effects. The potential for human exposure to Mn is gauged in terms of releases to the environment, environmental fate, levels monitored or estimated in the environment, and general population and occupational exposures. JF - HHS Report: Toxicological Profile for Manganese (Update) Y1 - 2000/09// PY - 2000 DA - Sep 2000 PB - U.S. Department of Health and Human Services, The Boulevard Kidlington Oxford OX5 1GB KW - Environment Abstracts KW - METAL CONCENTRATIONS KW - PATHOLOGY, HUMAN KW - POLLUTANT FATE KW - PUBLIC HEALTH KW - PATHOLOGY, ANIMALLABORATORY KW - MANGANESE KW - BIOACCUMULATION, HUMAN KW - HEALTH SAFETY, OCCUPATIONAL KW - DOSE RESPONSE PROFILES KW - CARCINOGENIC MECHANISMS KW - LITERATURE SURVEYS KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14555791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HHS+Report%3A+Toxicological+Profile+for+Manganese+%28Update%29&rft.atitle=Toxicological+profile+for+Manganese+%28Update%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=HHS+Report%3A+Toxicological+Profile+for+Manganese+%28Update%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Document feature - |n 2 |t diagrams N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - HEALTH SAFETY, OCCUPATIONAL; METAL CONCENTRATIONS; DOSE RESPONSE PROFILES; CARCINOGENIC MECHANISMS; PATHOLOGY, HUMAN; POLLUTANT FATE; PUBLIC HEALTH; PATHOLOGY, ANIMALLABORATORY; MANGANESE; BIOACCUMULATION, HUMAN; LITERATURE SURVEYS ER - TY - JOUR T1 - Toxicological Profile for Ethion AN - 14553465; 10595382 AB - Information concerning the physicochemical properties, toxicokinetocs, and key health end points of ethion is compiled. Health effects are listed by route of exposure to the organophosphate pesticide, and cover oral, inhalation, and dermal exposure pathways. Systemic, immunological and lymphoreticular, neurological, reproductive, developmental, genotoxic, and carcinogenic effects are delineated. Mechanisms of action, relevance to public health, biomarkers of exposure and effect, and methods for reducing toxic effects are included. The potential for human exposure is considered with reference to releases to the environment, environmental fate, and general population and occupational exposures. JF - HHS Report: Toxicological Profile for Ethion Y1 - 2000/09// PY - 2000 DA - Sep 2000 PB - U.S. Department of Health and Human Services, The Boulevard Kidlington Oxford OX5 1GB KW - Environment Abstracts KW - PESTICIDE RESIDUES KW - PUBLIC HEALTH KW - DOSE RESPONSE PROFILES KW - PATHOLOGY, HUMAN KW - POLLUTANT FATE KW - PATHOLOGY, ANIMALLABORATORY KW - ETHION KW - RISK ASSESSMENT KW - HEALTH SAFETY, OCCUPATIONAL KW - CARCINOGENIC MECHANISMS KW - PESTICIDE EXPOSURE KW - LITERATURE SURVEYS KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14553465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HHS+Report%3A+Toxicological+Profile+for+Ethion&rft.atitle=Toxicological+Profile+for+Ethion&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=HHS+Report%3A+Toxicological+Profile+for+Ethion&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Document feature - |n 3 |t diagrams N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - RISK ASSESSMENT; ETHION; HEALTH SAFETY, OCCUPATIONAL; DOSE RESPONSE PROFILES; CARCINOGENIC MECHANISMS; PESTICIDE RESIDUES; PATHOLOGY, HUMAN; POLLUTANT FATE; PUBLIC HEALTH; PATHOLOGY, ANIMALLABORATORY; PESTICIDE EXPOSURE; LITERATURE SURVEYS ER - TY - JOUR T1 - Toxicological Profile for Endosulfan (Update) AN - 14551691; 10595277 AB - Revised data on the environmental fate, toxicology, and public health significance of endosulfan exposure are synthesized. The effects of dermal, inhalation, and oral exposures to the insecticide are detailed and include systemic, immunological and lymphoreticular, neurological, reproductive, developmental, genotoxic, and carcinogenic effects. Absorption, distribution, and other aspects of toxicokinetics are covered, as are mechanisms of action, biomarkers of exposure and effect, interactions with other chemicals, and methods for reducing toxic effects. The potential for human exposure is gauged in terms of releases to the environment, levels monitored or estimated in the environment, and general population and occupational exposures. JF - HHS Report: Toxicological Profile for Endosulfan (Update) Y1 - 2000/09// PY - 2000 DA - Sep 2000 PB - US Department of Health and Human Services, The Boulevard Kidlington Oxford OX5 1GB KW - Environment Abstracts KW - PUBLIC HEALTH KW - BIOACCUMULATION, HUMAN KW - INSECTICIDE EXPOSURE KW - DOSE RESPONSE PROFILES KW - PATHOLOGY, HUMAN KW - POLLUTANT FATE KW - PATHOLOGY, ANIMALLABORATORY KW - INSECTICIDE RESIDUES KW - HEALTH SAFETY, OCCUPATIONAL KW - CARCINOGENIC MECHANISMS KW - ENDOSULFAN KW - LITERATURE SURVEYS KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14551691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HHS+Report%3A+Toxicological+Profile+for+Endosulfan+%28Update%29&rft.atitle=Toxicological+Profile+for+Endosulfan+%28Update%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=HHS+Report%3A+Toxicological+Profile+for+Endosulfan+%28Update%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Document feature - |n 3 |t diagrams N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - HEALTH SAFETY, OCCUPATIONAL; DOSE RESPONSE PROFILES; INSECTICIDE EXPOSURE; CARCINOGENIC MECHANISMS; PATHOLOGY, HUMAN; POLLUTANT FATE; PUBLIC HEALTH; PATHOLOGY, ANIMALLABORATORY; INSECTICIDE RESIDUES; ENDOSULFAN; BIOACCUMULATION, HUMAN; LITERATURE SURVEYS ER - TY - JOUR T1 - Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. AN - 72212711; 10960596 AB - Fluoro-Jade B, like its predecessor Fluoro-Jade, is an anionic fluorescein derivative useful for the histological staining of neurons undergoing degeneration. However, Fluoro-Jade B has an even greater specific affinity for degenerating neurons. This notion is supported by the conspicuous staining of degenerating neuronal elements with minimal background staining. This improved signal-to-noise ratio means that fine neuronal processes including distal dendrites, axons and axon terminals can be more readily detected and documented. Although the staining time and dye concentration are reduced, the method is as rapid, simple and reliable as the original Fluoro-Jade technique. Like Fluoro-Jade, Fluoro-Jade B is compatible with a number of other labeling procedures including immunofluorescent and fluorescent Nissl techniques. JF - Brain research AU - Schmued, L C AU - Hopkins, K J AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, 72079-9502, Jefferson, AR 72079-9502, USA. lschmued@nctr.fda.gov Y1 - 2000/08/25/ PY - 2000 DA - 2000 Aug 25 SP - 123 EP - 130 VL - 874 IS - 2 SN - 0006-8993, 0006-8993 KW - Fluoresceins KW - 0 KW - Fluorescent Dyes KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Kainic Acid -- pharmacology KW - Brain -- pathology KW - Brain -- drug effects KW - Staining and Labeling KW - Fluorescent Antibody Technique KW - Male KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72212711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Fluoro-Jade+B%3A+a+high+affinity+fluorescent+marker+for+the+localization+of+neuronal+degeneration.&rft.au=Schmued%2C+L+C%3BHopkins%2C+K+J&rft.aulast=Schmued&rft.aufirst=L&rft.date=2000-08-25&rft.volume=874&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-06 N1 - Date created - 2000-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different epitopes. AN - 71728728; 10924793 AB - Anti-tetanus toxoid monoclonal antibodies would be useful in exploring the relationship of tetanus toxin structure to its function. Tetanus toxin fragment C has been shown to be responsible for binding to neurons via gangliosides. Eleven new and two previously derived monoclonal antibodies specific for tetanus toxin fragment C were shown to recognize five different fragment C epitopes, two of which were overlapping. Three of these epitopes participate in the binding to ganglioside G(T1b). One epitope was defined by a monoclonal antibody that did not inhibit the interaction between fragment C and ganglioside. This antibody however, was blocked from binding to fragment C by antibodies that were able to inhibit the fragment C-ganglioside interaction. JF - Vaccine AU - Fitzsimmons, S P AU - Clark, K C AU - Wilkerson, R AU - Shapiro, M A AD - Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. Y1 - 2000/08/15/ PY - 2000 DA - 2000 Aug 15 SP - 114 EP - 121 VL - 19 IS - 1 SN - 0264-410X, 0264-410X KW - Antibodies, Monoclonal KW - 0 KW - Epitopes, B-Lymphocyte KW - Gangliosides KW - Peptide Fragments KW - Tetanus Toxin KW - tetanus toxin fragment C KW - trisialoganglioside GT1 KW - 59247-13-1 KW - Index Medicus KW - Animals KW - Binding, Competitive -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Epitopes, B-Lymphocyte -- immunology KW - Female KW - Cross Reactions KW - Structure-Activity Relationship KW - Tetanus Toxin -- immunology KW - Peptide Fragments -- metabolism KW - Tetanus Toxin -- antagonists & inhibitors KW - Tetanus Toxin -- metabolism KW - Gangliosides -- antagonists & inhibitors KW - Antibodies, Monoclonal -- pharmacology KW - Peptide Fragments -- immunology KW - Peptide Fragments -- antagonists & inhibitors KW - Gangliosides -- metabolism KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71728728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Inhibition+of+tetanus+toxin+fragment+C+binding+to+ganglioside+G%28T1b%29+by+monoclonal+antibodies+recognizing+different+epitopes.&rft.au=Fitzsimmons%2C+S+P%3BClark%2C+K+C%3BWilkerson%2C+R%3BShapiro%2C+M+A&rft.aulast=Fitzsimmons&rft.aufirst=S&rft.date=2000-08-15&rft.volume=19&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-11 N1 - Date created - 2000-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of Haber's Law in standard setting and risk assessment AN - 18010894; 4851281 AB - Haber's Law simply states that the incidence and/or severity of a toxic effect depends on the total exposure, i.e. exposure concentration (c) rate times the duration time (t) of exposure (c x t). This rule, within constraints, is often used in setting exposure guidelines for toxic substances. Establishing reference doses (acceptable daily intakes) for long-term exposures when only the results of short-term studies are available requires the use of an uncertainty (safety) factor. The value of this uncertainty factor often approximates a value comparable to Haber's Law for extrapolation from short-term to long-term exposure durations. As a default procedure, cancer risk estimates are generally based on the average lifetime daily dose which is derived from the total cumulative exposure, i.e. Haber's (c x t). This has been shown both theoretically and empirically to be valid within a factor of 20 for carcinogenesis. This provides some credence for the use of an additional safety factor of 10, in some instances, for exposures of children to carcinogens. Finally, a generalization of Haber's Law, exposure concentration raised to a power times exposure duration, is discussed. JF - Toxicology AU - Gaylor, D W AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, dgaylor@nctr.fda.gov Y1 - 2000/08/14/ PY - 2000 DA - 2000 Aug 14 SP - 17 EP - 19 VL - 149 IS - 1 SN - 0300-483X, 0300-483X KW - Haber's Law KW - concentration KW - Toxicology Abstracts KW - Risk assessment KW - Dose dependency KW - Dose-response effects KW - Carcinogens KW - X 24230:Legislation & recommended standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18010894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=The+use+of+Haber%27s+Law+in+standard+setting+and+risk+assessment&rft.au=Gaylor%2C+D+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=2000-08-14&rft.volume=149&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Special Issue: Fritz Haber and his Legacy to the Science of Toxicology. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Risk assessment; Carcinogens; Dose-response effects; Dose dependency ER - TY - JOUR T1 - Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide. AN - 71241465; 10880766 AB - The human glutathione S-transferase (GST) P1 alleles coding for Val(105) (hGSTP1*B and/or P1*C) are over- represented in lung cancer patients. However, the corresponding recombinant Val(105) protein variants tend to show higher catalytic activity than the Ile(105) variants towards bay-region diol epoxides that are thought to be etiological agents in lung cancer. We have examined 29 normal human lung samples with respect to several factors that could confound relationships between hGSTP1 allele type and cancer susceptibility, namely, inter-individual and allele-specific variation of hGSTP1 expression, and differences between the catalytic properties of the native and recombinant hGSTP1-1 variant protein products. hGSTP1 expression varied 7-fold among individuals but was independent of hGSTP1*A, P1*B or P1*C allele type. hGST subunits A1, A2, M1 and M3 were minor components, similarly variable in expression. Despite this variability of expression, the levels of hGSTP1 expression linearly correlated with those of the next most highly expressed GST, hGSTM3, even though the genes for these GSTs are on different chromosomes. Differences between the native protein variants, using 1-chloro-2,4-dinitrobenzene and (+)-anti-benzo[a]pyrene diolepoxide as substrates, were more marked than those between the recombinant variants. However, the order of differential catalytic specificity was the same for native and recombinant variants. Neither the expression of the hGSTP1 alleles nor the catalytic properties of the protein variants appears to provide a simple mechanistic rationale for the observed over-representation of the hGSTP1*B and/or 1*C alleles in lung cancer. JF - Cancer letters AU - Coles, B AU - Yang, M AU - Lang, N P AU - Kadlubar, F F AD - Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA. bcoles@nctr.fda.gov Y1 - 2000/08/11/ PY - 2000 DA - 2000 Aug 11 SP - 167 EP - 175 VL - 156 IS - 2 SN - 0304-3835, 0304-3835 KW - Carcinogens KW - 0 KW - Isoenzymes KW - Pyridines KW - Recombinant Proteins KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Glutathione Transferase KW - Dinitrochlorobenzene KW - GE3IBT7BMN KW - 4-vinylpyridine KW - I56G67XM8D KW - Index Medicus KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- pharmacokinetics KW - Pyridines -- pharmacokinetics KW - Humans KW - Recombinant Proteins -- genetics KW - Genotype KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- metabolism KW - Dinitrochlorobenzene -- pharmacokinetics KW - Recombinant Proteins -- metabolism KW - Dinitrochlorobenzene -- metabolism KW - Genetic Predisposition to Disease -- genetics KW - Kinetics KW - Genetic Variation -- genetics KW - Substrate Specificity KW - Inactivation, Metabolic -- genetics KW - Pyridines -- metabolism KW - Individuality KW - Catalysis KW - Alleles KW - Carcinogens -- metabolism KW - Isoenzymes -- biosynthesis KW - Carcinogens -- pharmacokinetics KW - Glutathione Transferase -- metabolism KW - Glutathione Transferase -- biosynthesis KW - Lung -- enzymology KW - Glutathione Transferase -- genetics KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71241465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Expression+of+hGSTP1+alleles+in+human+lung+and+catalytic+activity+of+the+native+protein+variants+towards+1-chloro-2%2C4-dinitrobenzene%2C+4-vinylpyridine+and+%28%2B%29-anti+benzo%5Ba%5Dpyrene-7%2C8-diol-9%2C10-oxide.&rft.au=Coles%2C+B%3BYang%2C+M%3BLang%2C+N+P%3BKadlubar%2C+F+F&rft.aulast=Coles&rft.aufirst=B&rft.date=2000-08-11&rft.volume=156&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-06 N1 - Date created - 2000-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Report of the FDA Retail Food Program Database of Foodborne Illness Risk Factors AN - 59811206; 2000-1002420 AB - Discusses the project begun in 1997 to establish a baseline against which industry and regulatory efforts to change behaviors and practices directly related to foodborne illness will be measured; US. Issued by the FDA's Center for Food Safety and Applied Nutrition. JF - United States Food and Drug Administration Center for Food Safety and Applied Nutrition, August 10 2000. Y1 - 2000/08/10/ PY - 2000 DA - 2000 Aug 10 PB - United States Food and Drug Administration Center for Food Safety and Applied Nutrition KW - Data base systems -- Government use KW - Food contamination and inspection -- United States KW - Diseases -- Prevention KW - United States -- Food and drug administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59811206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-08-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Report+of+the+FDA+Retail+Food+Program+Database+of+Foodborne+Illness+Risk+Factors&rft.title=Report+of+the+FDA+Retail+Food+Program+Database+of+Foodborne+Illness+Risk+Factors&rft.issn=&rft_id=info:doi/ L2 - http://vm.cfsan.fda.gov/~dms/retrsk.html LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Food and Drug Admin Center for Food Safety and Applied Nutrition N1 - Document feature - table(s), link(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Comparison of three sampling and analytical methods for the determination of airborne hexavalent chromium. AN - 72592173; 11249787 AB - A field study was conducted with the goal of comparing the performance of three recently developed or modified sampling and analytical methods for the determination of airborne hexavalent chromium (Cr(VI)). The study was carried out in a hard chrome electroplating facility and in a jet engine manufacturing facility where airborne Cr(VI) was expected to be present. The analytical methods evaluated included two laboratory-based procedures (OSHA Method ID-215 and NIOSH Method 7605) and a field-portable method (NIOSH Method 7703). These three methods employ an identical sampling methodology: collection of Cr(VI)-containing aerosol on a polyvinyl chloride (PVC) filter housed in a sampling cassette, which is connected to a personal sampling pump calibrated at an appropriate flow rate. The basis of the analytical methods for all three methods involves extraction of the PVC filter in alkaline buffer solution, chemical isolation of the Cr(VI) ion, complexation of the Cr(VI) ion with 1,5-diphenylcarbazide, and spectrometric measurement of the violet chromium diphenylcarbazone complex at 540 nm. However, there are notable specific differences within the sample preparation procedures used in three methods. To assess the comparability of the three measurement protocols, a total of 20 side-by-side air samples were collected, equally divided between a chromic acid electroplating operation and a spray paint operation where water soluble forms of Cr(VI) were used. A range of Cr(VI) concentrations from 0.6 to 960 microg m(-3), with Cr(VI) mass loadings ranging from 0.4 to 32 microg, was measured at the two operations. The equivalence of the means of the log-transformed Cr(VI) concentrations obtained from the different analytical methods was compared. Based on analysis of variance (ANOVA) results, no statistically significant differences were observed between mean values measured using each of the three methods. Small but statistically significant differences were observed between results obtained from performance evaluation samples for the NIOSH field method and the OSHA laboratory method. JF - Journal of environmental monitoring : JEM AU - Boiano, J M AU - Wallace, M E AU - Sieber, W K AU - Groff, J H AU - Wang, J AU - Ashley, K AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 329 EP - 333 VL - 2 IS - 4 SN - 1464-0325, 1464-0325 KW - Air Pollutants KW - 0 KW - Carcinogens, Environmental KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Paint KW - United States Occupational Safety and Health Administration KW - Electroplating KW - Air Pollutants -- analysis KW - Quality Control KW - National Institute for Occupational Safety and Health (U.S.) KW - Industry KW - Chromium -- analysis KW - Carcinogens, Environmental -- analysis KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72592173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Comparison+of+three+sampling+and+analytical+methods+for+the+determination+of+airborne+hexavalent+chromium.&rft.au=Boiano%2C+J+M%3BWallace%2C+M+E%3BSieber%2C+W+K%3BGroff%2C+J+H%3BWang%2C+J%3BAshley%2C+K&rft.aulast=Boiano&rft.aufirst=J&rft.date=2000-08-01&rft.volume=2&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biotransformation of 13(Z)-retinoic acid in mouse skin and human keratinocyte cultures. AN - 72577920; 11221542 AB - The metabolism of 13-(CIS) in mouse skin in vivo which was treated with TPA (or vehicle) typically showed that the retinoid was oxidized to 4-hydroxy, 5,6-epoxy-13-CIS, 5,8-oxy-13-CIS and undergoes geometric isomerization to RA. Applied 13-(CIS) in human keratinocyte cultures showed that the retinoid was oxidized to 5,6-epoxy-13-CIS, 5,8-oxy-13-CIS, and isomers. Pretreatment with the antioxidant butylated hydroxyanisole(BHA) resulted in a large decrease in formation of the oxirane and increased formation of the alcohol in mouse skin. Proposed mechanisms suggested the involvement of peroxyl radicals and prostaglandin H synthase for the biotransformation of retinoids. JF - The Kaohsiung journal of medical sciences AU - Chang, H C AU - Samokyszyn, V M AD - Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 387 EP - 392 VL - 16 IS - 8 SN - 1607-551X, 1607-551X KW - Butylated Hydroxyanisole KW - 25013-16-5 KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Biotransformation KW - Humans KW - Mice KW - Female KW - Chromatography, High Pressure Liquid KW - Butylated Hydroxyanisole -- pharmacology KW - Isotretinoin -- pharmacokinetics KW - Skin -- metabolism KW - Keratinocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72577920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Kaohsiung+journal+of+medical+sciences&rft.atitle=Biotransformation+of+13%28Z%29-retinoic+acid+in+mouse+skin+and+human+keratinocyte+cultures.&rft.au=Chang%2C+H+C%3BSamokyszyn%2C+V+M&rft.aulast=Chang&rft.aufirst=H&rft.date=2000-08-01&rft.volume=16&rft.issue=8&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=The+Kaohsiung+journal+of+medical+sciences&rft.issn=1607551X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of storage at 4 degrees C on the stability of ampicillin residues in raw milk. AN - 72328560; 11027028 AB - Raw milk samples collected from tanker trucks are routinely screened for beta-lactam antibiotic drug residues using rapid screening tests. If drug residues are detected, the milk may be shipped on ice blocks to a laboratory for further analysis. A study was conducted to determine the stability of ampicillin in raw milk stored at +4 degrees C in order to predict if shipping the milk would result in the degradation of ampicillin residues. Milk samples were spiked with 20 ppb ampicillin, stored at +4 degrees C and -70 degrees C for 1-6 days, and then analysed by HPLC with fluorescence detection. No loss of ampicillin residues was found in milk stored at +4 degrees C for 1-6 days. JF - Food additives and contaminants AU - Schenck, F J AU - Friedman, S L AD - Baltimore District Laboratory, Food and Drug Administration, MD 21201, USA. fschenck@ora.fda.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 675 EP - 677 VL - 17 IS - 8 SN - 0265-203X, 0265-203X KW - Penicillins KW - 0 KW - Ampicillin KW - 7C782967RD KW - Index Medicus KW - Drug Stability KW - Animals KW - Transportation KW - Food Contamination -- analysis KW - Freezing KW - Chromatography, High Pressure Liquid KW - Refrigeration KW - Penicillins -- analysis KW - Food Preservation -- methods KW - Ampicillin -- analysis KW - Milk -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72328560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=The+effect+of+storage+at+4+degrees+C+on+the+stability+of+ampicillin+residues+in+raw+milk.&rft.au=Schenck%2C+F+J%3BFriedman%2C+S+L&rft.aulast=Schenck&rft.aufirst=F&rft.date=2000-08-01&rft.volume=17&rft.issue=8&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aseptic necrosis in HIV seropositive patients: a possible etiologic role for megestrol acetate. AN - 72248388; 10977969 AB - The association between pharmacologic doses of corticosteroids and the development of aseptic bone necrosis has been well documented. Recent reports have described the corticosteroid activity of megestrol acetate. A retrospective review of adverse events reported to the U.S. Food and Drug Administration identified three human immunodeficiency virus (HIV) seropositive patients who developed avascular necrosis of the femoral head during treatment with megestrol acetate. All were males, ages 34, 36, and 55 years, and were on therapy for 6, 1.5, and 18 months, respectively, when symptoms of aseptic necrosis occurred in the absence of antecedent trauma. Megestrol acetate doses were 640, 320, and 600-1200 mg/d, respectively. Two patients had no history of corticosteroid use whereas the third had taken an undisclosed dose and duration of corticosteroids concurrent with pentamidine administration. Notably, despite the predominant use of megestrol in women for hormone sensitive malignancies, none of the reports of aseptic necrosis occurred in this population. Megestrol acetate may be associated with the development of avascular necrosis via its glucocorticoid-like effects. Cachectic acquired immunodeficiency syndrome (AIDS) patients may have additional risk factors that predispose them to aseptic necrosis when receiving megestrol acetate. JF - AIDS patient care and STDs AU - Koller, E AU - Mann, M AU - Malozowski, S AU - Bacsanyi, J AU - Gibert, C AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA. Kollere@cder.fda.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 405 EP - 410 VL - 14 IS - 8 SN - 1087-2914, 1087-2914 KW - Megestrol Acetate KW - TJ2M0FR8ES KW - AIDS/HIV KW - Magnetic Resonance Imaging KW - Causality KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Adult KW - Retrospective Studies KW - Middle Aged KW - Male KW - HIV Wasting Syndrome -- drug therapy KW - Femur Head Necrosis -- chemically induced KW - HIV Wasting Syndrome -- complications KW - Femur Head Necrosis -- diagnosis KW - Megestrol Acetate -- adverse effects KW - Femur Head Necrosis -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72248388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+patient+care+and+STDs&rft.atitle=Aseptic+necrosis+in+HIV+seropositive+patients%3A+a+possible+etiologic+role+for+megestrol+acetate.&rft.au=Koller%2C+E%3BMann%2C+M%3BMalozowski%2C+S%3BBacsanyi%2C+J%3BGibert%2C+C&rft.aulast=Koller&rft.aufirst=E&rft.date=2000-08-01&rft.volume=14&rft.issue=8&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=AIDS+patient+care+and+STDs&rft.issn=10872914&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-10 N1 - Date created - 2001-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol enhances Nicotine's effects on DRL performance in rats. AN - 72234871; 10973521 AB - The present experiment examined effects of nicotine (0.0, 0.3, 0.56, and 1.0 mg/kg; IP) and ethanol (0.0, 0.5, 1.5, and 3.0 g/kg; IG) on operant behavior using a differential reinforcement of low response rate (DRL) schedule in rats. DRL schedules are sensitive to effects of nicotine and provide an assessment of the subject's ability to accurately estimate time and to inhibit schedule-controlled responding. When administered alone, nicotine shifted the mode of the interresponse time distribution to the left and reduced the percentage of reinforced responses. Nicotine also had an inverted U-shaped dose effect on the number of "bursting" responses. When administered after pretreatment with ethanol, nicotine's effects on the distribution of interresponse times and bursting were potentiated. These effects are consistent with previous reports and with the suggestion that ethanol pretreatment can potentiate effects of subsequently administered nicotine. Published by Elsevier Science Inc. JF - Pharmacology, biochemistry, and behavior AU - Popke, E J AU - Fogle, C M AU - Paule, M G AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079-9502, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 819 EP - 826 VL - 66 IS - 4 SN - 0091-3057, 0091-3057 KW - Central Nervous System Depressants KW - 0 KW - Nicotinic Agonists KW - Ethanol KW - 3K9958V90M KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Rats KW - Reaction Time -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Male KW - Conditioning, Operant -- drug effects KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72234871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Ethanol+enhances+Nicotine%27s+effects+on+DRL+performance+in+rats.&rft.au=Popke%2C+E+J%3BFogle%2C+C+M%3BPaule%2C+M+G&rft.aulast=Popke&rft.aufirst=E&rft.date=2000-08-01&rft.volume=66&rft.issue=4&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Another type of medication error: dilution/reconstitution. AN - 72211260; 10963525 JF - Southern medical journal AU - Varricchio, F AD - Division of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 834 VL - 93 IS - 8 SN - 0038-4348, 0038-4348 KW - Albumins KW - 0 KW - Antineoplastic Agents KW - Interleukin-11 KW - Recombinant Proteins KW - oprelvekin KW - 145941-26-0 KW - Glucagon KW - 9007-92-5 KW - Abridged Index Medicus KW - Index Medicus KW - Glucagon -- chemistry KW - Albumins -- chemistry KW - Glucagon -- adverse effects KW - Chemistry, Pharmaceutical KW - Humans KW - Interleukin-11 -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Albumins -- adverse effects KW - Adverse Drug Reaction Reporting Systems KW - Recombinant Proteins -- adverse effects KW - Recombinant Proteins -- chemistry KW - Interleukin-11 -- chemistry KW - Antineoplastic Agents -- chemistry KW - Drug Compounding -- adverse effects KW - Drug Compounding -- methods KW - Medication Errors -- prevention & control KW - Medication Errors -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72211260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Another+type+of+medication+error%3A+dilution%2Freconstitution.&rft.au=Varricchio%2C+F&rft.aulast=Varricchio&rft.aufirst=F&rft.date=2000-08-01&rft.volume=93&rft.issue=8&rft.spage=834&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-07 N1 - Date created - 2000-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Electrostatic N-95 respirator filter media efficiency degradation resulting from intermittent sodium chloride aerosol exposure. AN - 72209827; 10957815 AB - The effects of intermittently loading small masses of sodium chloride aerosol on the filtration efficiency of N-95 filtering facepiece respirators was investigated. The National Institute for Occupational Safety and Health (NIOSH) certifies that N-95 respirators must provide at least 95 percent filtration efficiency against a sodium chloride aerosol challenge as per the respirator certification (42 CFR 84) test criteria. N-95 respirators are specified for protection against solid and water-based particulates (i.e., non-oil aerosols). New N-95 respirators from three different manufacturers were loaded with 5 +/- 1 mg of sodium chloride aerosol one day a week, over a period of weeks. Aerosol loading and penetration measurements were performed using the TSI 8130 Filter Tester. Respirators were stored uncovered on an office desktop outside the laboratory. To investigate environmental and temporal effects of filters being stored without sodium chloride exposure, control respirators were stored on the desk for various lengths of time before being initiated into weekly testing. For all manufacturers' respirators, the controls showed similar initial penetrations on their day of initiation (day zero) to those of the study samples on day zero. As the controls were tested weekly, they showed similar degradation rates to those of the study samples. Results show that some of the manufacturers' models had penetrations of greater than 5 percent when intermittently exposed to sodium chloride aerosol. It is concluded that intermittent, low-level sodium chloride aerosol loading of N-95 respirators has a degrading effect on filter efficiency. This reduction in filter efficiency was not accompanied by a significant increase in breathing resistance that would signal the user that the filter needs to be replaced. Furthermore, it was noted that the effect of room storage time prior to initial exposure was much less significant. JF - Applied occupational and environmental hygiene AU - Moyer, E S AU - Bergman, M S AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 600 EP - 608 VL - 15 IS - 8 SN - 1047-322X, 1047-322X KW - Aerosols KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Static Electricity KW - Filtration KW - Equipment Design KW - Inhalation Exposure KW - Humans KW - Occupational Health KW - Respiratory Protective Devices -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72209827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Electrostatic+N-95+respirator+filter+media+efficiency+degradation+resulting+from+intermittent+sodium+chloride+aerosol+exposure.&rft.au=Moyer%2C+E+S%3BBergman%2C+M+S&rft.aulast=Moyer&rft.aufirst=E&rft.date=2000-08-01&rft.volume=15&rft.issue=8&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-21 N1 - Date created - 2000-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical and biological terrorism preparedness--Web-based resources. AN - 72209139; 10957813 JF - Applied occupational and environmental hygiene AU - Gao, L L AU - Miller, A AU - Daniels, W J AD - U.S. Public Health Service Region VIII, Denver, Colorado 80294, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 592 EP - 595 VL - 15 IS - 8 SN - 1047-322X, 1047-322X KW - Index Medicus KW - Information Services KW - Humans KW - Chemical Warfare KW - Disaster Planning KW - Biological Warfare KW - Violence KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72209139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Chemical+and+biological+terrorism+preparedness--Web-based+resources.&rft.au=Gao%2C+L+L%3BMiller%2C+A%3BDaniels%2C+W+J&rft.aulast=Gao&rft.aufirst=L&rft.date=2000-08-01&rft.volume=15&rft.issue=8&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-21 N1 - Date created - 2000-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Feasibility of a defined microflora challenge method for evaluating the efficacy of foodborne Listeria monocytogenes selective enrichments. AN - 71765333; 10945582 AB - Comparison of isolation methods for microbial pathogens is complicated by the variable interference caused by the competitive microflora present in test samples such as foods. In principle, using measured amounts of a standard competitor in a defined surrogate food matrix might control the effect of variable interference. This possibility was investigated using Listeria monocytogenes and enrichment broths belonging to the acriflavine-nalidixate selective agent class. Triplicate test sample sets were prepared. Each set consisted of suspensions of variable levels of the standard competitor, Enterococcus faecium strain 111 (approximately 10 to 10(9) CFU/25 g), mixed with a low constant level (10 to 100 CFU/25 g) of L. monocytogenes. These test samples were enriched at 30 degrees C for 48 h in different selective media and streaked onto selective isolation agars. The input CFU ratio (E. faecium/L. monocytogenes) that permitted a 50% end point L. monocytogenes recovery was 2.2 x 10(6) or higher for the Food and Drug Administration one-step enrichments and 0.8 x 10(6) for the International Standards Organization (ISO) two-step enrichment. These and other results show that this evaluation method is feasible with this class of enrichments. Interestingly, L. monocytogenes could be detected in enrichment cultures at high-input E. faecium/L. monocytogenes ratios even when the enriched samples were plated onto nonselective media. The pinpoint colonies of L. monocytogenes embedded in a confluent lawn of E. faecium 111 were detectable by their contrasting coloration in Henry obliquely transmitted illumination. JF - Journal of food protection AU - Hitchins, A D AU - Duvall, R E AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204-0001, USA. adh@cfsan.fda.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 1064 EP - 1070 VL - 63 IS - 8 SN - 0362-028X, 0362-028X KW - Culture Media KW - 0 KW - Agar KW - 9002-18-0 KW - Index Medicus KW - Animals KW - Agar -- chemistry KW - Colony Count, Microbial KW - Bacteriological Techniques KW - Culture Media -- chemistry KW - Listeria monocytogenes -- isolation & purification KW - Food Microbiology KW - Listeria monocytogenes -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71765333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Feasibility+of+a+defined+microflora+challenge+method+for+evaluating+the+efficacy+of+foodborne+Listeria+monocytogenes+selective+enrichments.&rft.au=Hitchins%2C+A+D%3BDuvall%2C+R+E&rft.aulast=Hitchins&rft.aufirst=A&rft.date=2000-08-01&rft.volume=63&rft.issue=8&rft.spage=1064&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-21 N1 - Date created - 2000-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protecting consumers by safeguarding animal health. AN - 71758661; 10950218 JF - American family physician AU - Sundlof, S F AD - U.S. Food and Drug Administration, Rockville, Maryland, USA. Y1 - 2000/08/01/ PY - 2000 DA - 2000 Aug 01 SP - 659 EP - 660 VL - 62 IS - 3 SN - 0002-838X, 0002-838X KW - Veterinary Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Animals KW - Cattle KW - Animal Feed KW - Food Microbiology KW - Humans KW - Drug Resistance, Microbial KW - Food Irradiation KW - Encephalopathy, Bovine Spongiform -- prevention & control KW - United States Food and Drug Administration KW - Veterinary Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71758661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Protecting+consumers+by+safeguarding+animal+health.&rft.au=Sundlof%2C+S+F&rft.aulast=Sundlof&rft.aufirst=S&rft.date=2000-08-01&rft.volume=62&rft.issue=3&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-05 N1 - Date created - 2000-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Silicosis and coal workers' pneumoconiosis. AN - 71755519; 10931786 AB - Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the etiology of CWP and silicosis: a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; d) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms. JF - Environmental health perspectives AU - Castranova, V AU - Vallyathan, V AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. vic1@cdc.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 675 EP - 684 VL - 108 Suppl 4 SN - 0091-6765, 0091-6765 KW - Air Pollutants, Occupational KW - 0 KW - Coal KW - Index Medicus KW - Humans KW - Silicosis -- etiology KW - Pneumoconiosis -- etiology KW - Air Pollutants, Occupational -- adverse effects KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71755519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Silicosis+and+coal+workers%27+pneumoconiosis.&rft.au=Castranova%2C+V%3BVallyathan%2C+V&rft.aulast=Castranova&rft.aufirst=V&rft.date=2000-08-01&rft.volume=108+Suppl+4&rft.issue=&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - 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Last updated - 2017-01-18 ER - TY - JOUR T1 - Transplacental pharmacokinetics and fetal distribution of 2', 3'-didehydro-3'-deoxythymidine (d4T) and its metabolites in late-term rhesus macaques. AN - 71754572; 10931506 AB - The overall goal of human immunodeficiency virus (HIV) therapy during pregnancy is to maintain maternal health and reduce the probability of vertical transmission during gestation and delivery, while keeping toxicity risks low. Azidothymidine (AZT) is currently recommended for pregnant women infected with HIV; however, many pregnant women are unable to tolerate AZT because of toxicity. In the present study, the placental transfer and fetal accumulation of the anti-HIV compound 2',3'-didehydro-3'-deoxythymidine (d4T) and its active (triphosphorylated) and inactive (thymine and beta-aminoisobutyric acid) metabolites were examined at steady state in late-term rhesus macaques. On the day of the hysterotomy, the mother was administered an intravenous loading dose of d4T, followed by a 3-hr steady-state intravenous infusion that also included [(3)H]d4T as a tracer. After 3 hr of infusion, the fetus was delivered by cesarean section under halothane/N(2)O anesthesia. Plasma, amniotic fluid, and tissues were analyzed for d4T and its inactive metabolites by HPLC; tissue samples were analyzed for d4T and active (phosphorylated) metabolites by strong anion-exchange HPLC. Maternal steady-state plasma concentrations of d4T were 1-2 microg/ml, with a fetal-to-maternal plasma ratio of 0.85 +/- 0.09. The fetal tissue distribution of radioactivity was highest in the kidney and lowest in the brain. D4T, thymine, and beta-aminoisobutyric acid were detected in all fetal tissues examined. Our data indicate that d4T readily crosses the placenta and is present in the fetus as parent compound or its inactive metabolites after maternal infusion. Although fetal plasma concentrations of d4T were similar to clinical d4T concentrations, no phosphorylated metabolites were detected. Teratology 62:93-99, 2000. Published 2000 Wiley-Liss, Inc. JF - Teratology AU - Patterson, T A AU - Binienda, Z K AU - Newport, G D AU - Lipe, G W AU - Gillam, M P AU - Slikker, W AU - Sandberg, J A AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079-9502, USA. tucker.patterson@mail.state.ar.us Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 93 EP - 99 VL - 62 IS - 2 SN - 0040-3709, 0040-3709 KW - Aminoisobutyric Acids KW - 0 KW - Anti-HIV Agents KW - 3-aminoisobutyric acid KW - 144-90-1 KW - Stavudine KW - BO9LE4QFZF KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - AIDS/HIV KW - Maternal-Fetal Exchange KW - Animals KW - Thymine -- pharmacokinetics KW - Kidney -- embryology KW - Kidney -- drug effects KW - Tissue Distribution KW - Time Factors KW - Female KW - Chromatography, High Pressure Liquid KW - Aminoisobutyric Acids -- pharmacokinetics KW - Pregnancy KW - Anti-HIV Agents -- pharmacokinetics KW - Macaca mulatta -- embryology KW - Anti-HIV Agents -- metabolism KW - Stavudine -- blood KW - Stavudine -- metabolism KW - Placenta -- drug effects KW - Stavudine -- pharmacokinetics KW - Anti-HIV Agents -- blood KW - Fetus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71754572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Transplacental+pharmacokinetics+and+fetal+distribution+of+2%27%2C+3%27-didehydro-3%27-deoxythymidine+%28d4T%29+and+its+metabolites+in+late-term+rhesus+macaques.&rft.au=Patterson%2C+T+A%3BBinienda%2C+Z+K%3BNewport%2C+G+D%3BLipe%2C+G+W%3BGillam%2C+M+P%3BSlikker%2C+W%3BSandberg%2C+J+A&rft.aulast=Patterson&rft.aufirst=T&rft.date=2000-08-01&rft.volume=62&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-02 N1 - Date created - 2000-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro cytotoxicity tests on cultured human skin fibroblasts to predict skin irritation potential of surfactants. AN - 71250272; 10906441 AB - Cultured human skin cells are a potentially useful model for skin irritancy testing. We have investigated the use of human skin fibroblasts for in vitro screening for skin toxicity. To assess the cytotoxic effects of surfactants, cell viability was measured by the NRU (neutral red uptake) assay and AB (Alamar blue) assay as in vitro methods. The skin irritation potential of surfactants by human skin patch test was assessed as in vivo methods. The close relationship was found between AB assay with human skin fibroblasts and human patch test (r=0.867). There was a relatively good agreement between the NRU and in vivo patch test (r=0.648). These results suggest that AB and NRU assay using cultured human fibroblast could be predictable methods for the irritancy of various surfactants in human. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Lee, J K AU - Kim, D B AU - Kim, J I AU - Kim, P Y AD - Department of Toxicology, National Institute of Toxicology Research, Korea Food and Drug Administration, 122-704, Seoul, South Korea. jkleest@yahoo.com Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 345 EP - 349 VL - 14 IS - 4 SN - 0887-2333, 0887-2333 KW - Irritants KW - 0 KW - Surface-Active Agents KW - Neutral Red KW - 261QK3SSBH KW - Index Medicus KW - Fibroblasts -- drug effects KW - Reproducibility of Results KW - Humans KW - Infant, Newborn KW - Fibroblasts -- cytology KW - Patch Tests KW - Predictive Value of Tests KW - Neutral Red -- metabolism KW - Fibroblasts -- metabolism KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Adult KW - Toxicity Tests KW - Animal Testing Alternatives KW - Skin -- drug effects KW - Skin -- metabolism KW - Irritants -- toxicity KW - Surface-Active Agents -- toxicity KW - Skin -- cytology KW - Irritants -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71250272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=In+vitro+cytotoxicity+tests+on+cultured+human+skin+fibroblasts+to+predict+skin+irritation+potential+of+surfactants.&rft.au=Lee%2C+J+K%3BKim%2C+D+B%3BKim%2C+J+I%3BKim%2C+P+Y&rft.aulast=Lee&rft.aufirst=J&rft.date=2000-08-01&rft.volume=14&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=08872333&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-17 N1 - Date created - 2000-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nonfatal work-related inhalations: surveillance data from hospital emergency departments, 1995-1996. AN - 71240172; 10893507 AB - Data from a stratified sample of hospital emergency rooms in the USA were used to describe nonfatal work-related inhalation injuries and illnesses during July 1995 to July 1996. Information was abstracted from emergency room records by the Consumer Product Safety Commission (CPSC) as part of the National Electronic Injury Surveillance System (NEISS) for all work-related injuries and illnesses regardless of product involvement. There were an estimated 44,423 occupational inhalation cases nationwide, with an annual rate of 3.6 cases/10(4) workers/year. The rate for men (4.4 cases/10(4)) was greater than that observed for women (2.6 cases/10(4)), and the rates tended to decline with increasing age. An estimated 4.6% of the cases were hospitalized for further treatment. The highest rate by industry was 16.4 cases/10(4) for public administration (which included fire and police departments). Among non-firefighters, there were an estimated 6,470 cases nationwide in which respiratory symptoms or conditions were noted, which yielded an annual rate of 0.5 cases/10(4) (95% CI 0.3, 0.7). Chlorine compounds were a common agent for the cases with adverse respiratory outcomes. The NEISS data provide an efficient method to learn about the national frequency of work-related inhalation injuries and illnesses. The National Institute for Occupational Safety and Health (NIOSH) is exploring two ways to use these data: first, to routinely review the reports to conduct surveillance for work-related inhalation cases; and second, to consider working with CPSC to conduct follow-back interviews of selected cases in order to learn more about the circumstances of the exposure, prior training of the case, and outcome of the exposure. Am. J. Ind. Med. 38:140-148, 2000. Published 2000 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Henneberger, P K AU - Metayer, C AU - Layne, L A AU - Althouse, R AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 140 EP - 148 VL - 38 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Humans KW - Adult KW - Emergency Service, Hospital -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Population Surveillance KW - Respiratory Tract Diseases -- etiology KW - Respiratory Tract Diseases -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71240172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Nonfatal+work-related+inhalations%3A+surveillance+data+from+hospital+emergency+departments%2C+1995-1996.&rft.au=Henneberger%2C+P+K%3BMetayer%2C+C%3BLayne%2C+L+A%3BAlthouse%2C+R&rft.aulast=Henneberger&rft.aufirst=P&rft.date=2000-08-01&rft.volume=38&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-22 N1 - Date created - 2000-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Temporary Assistance for Needy Families (TANF) program: third annual report to Congress AN - 59812989; 2000-0906140 AB - Data about welfare caseloads, family employment and earnings, marriage and two-parent families, out-of-wedlock births, and state policy choices; since 1996, chiefly; US. JF - United States Department of Health and Human Services, August 2000. Y1 - 2000/08// PY - 2000 DA - August 2000 PB - United States Department of Health and Human Services KW - Wages and salaries -- United States -- Statistics KW - Public welfare -- United States -- Statistics KW - Family allowances -- United States -- Statistics KW - Unmarried couples -- United States -- Statistics KW - Births -- United States -- Statistics KW - United States -- Social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59812989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Temporary+Assistance+for+Needy+Families+%28TANF%29+program%3A+third+annual+report+to+Congress&rft.title=Temporary+Assistance+for+Needy+Families+%28TANF%29+program%3A+third+annual+report+to+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.acf.dhhs.gov/programs/opre/annual3.pdf LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Document feature - table(s), chart(s), map(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Chemical characterization and bioactivity of polycyclic aromatic hydrocarbons from non-oxidative thermal treatment of pyrene-contaminated soil at 250-1,000 degrees C AN - 52254223; 2001-021456 AB - In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a constant flow of helium gas at 250, 500, 750, and 1,000+ or -20 degrees C. Dichloromethane (DCM) extracts of cooled residues of heated soil and of volatiles condensed on a cold finger after 1 sec residence time at furnace temperature were assayed gravimetrically and analyzed for PAH by HPLC, HPLC coupled to mass spectrometry, and gas chromatography coupled to mass spectrometry. All four temperatures volatilized pyrene and generated other PAHs, including alkylated pyrenes. We detected bioactive PAHs in the product volatiles: cyclopenta[cd]pyrene (CPP) at 750 and 1,000 degrees C and benzo[a]pyrene (BaP) at 1,000 degrees C. We found a clean soil residue, i.e., no pyrene or other DCM extracts, only at 750 degrees C. Control experiments with uncontaminated soil, pyrene, and Ottawa sand plus 4.89 wt% pyrene revealed no CPP or BaP production from soil itself, but these experiments imply that pyrene interactions with soil, e.g., soil-bound silica, stimulate CPP and BaP production. We detected mutagenicity to human diploid lymphoblasts (in vitro) in volatiles from 1,000 degrees C heating of soil plus pyrene and sand plus pyrene, and in the residue from 500 degrees C heating of soil plus pyrene. Three plausible pathways for pyrene conversion to other PAHs are a) a reaction with light gas species, e.g., soil-or pyrene-derived acetylene; b) loss of C (sub 2) -units followed by reaction with a PAH; and c) dimerization with further molecular weight growth via cyclodehydrogenation. This study shows that thermal treatment of PAH-polluted soil may generate toxic by-products that require further cleanup by oxidation or other measures. JF - Environmental Health Perspectives AU - Richter, Henning AU - Risoul, Veronique AU - Lafleur, Arthur L AU - Plummer, Elaine F AU - Howard, Jack B AU - Peters, William A Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 709 EP - 717 PB - U. S. Department of Health and Human Services, Public Health Service, Research Triangle Park, NC VL - 108 IS - 8 SN - 0091-6765, 0091-6765 KW - soils KW - pollutants KW - gas chromatograms KW - characterization KW - soil treatment KW - pollution KW - mass spectra KW - temperature KW - volatiles KW - pyrene KW - organic compounds KW - decontamination KW - hydrocarbons KW - chemical properties KW - polycyclic aromatic hydrocarbons KW - heating KW - spectra KW - thermal effects KW - geochemistry KW - aromatic hydrocarbons KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52254223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Chemical+characterization+and+bioactivity+of+polycyclic+aromatic+hydrocarbons+from+non-oxidative+thermal+treatment+of+pyrene-contaminated+soil+at+250-1%2C000+degrees+C&rft.au=Richter%2C+Henning%3BRisoul%2C+Veronique%3BLafleur%2C+Arthur+L%3BPlummer%2C+Elaine+F%3BHoward%2C+Jack+B%3BPeters%2C+William+A&rft.aulast=Richter&rft.aufirst=Henning&rft.date=2000-08-01&rft.volume=108&rft.issue=8&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ L2 - http://www.jstor.org/journals/00916765.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 36 N1 - PubXState - NC N1 - Document feature - illus. incl. 7 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aromatic hydrocarbons; characterization; chemical properties; decontamination; gas chromatograms; geochemistry; heating; hydrocarbons; mass spectra; organic compounds; pollutants; pollution; polycyclic aromatic hydrocarbons; pyrene; soil treatment; soils; spectra; temperature; thermal effects; volatiles ER - TY - JOUR T1 - Coal mine seismicity and bumps; historical case studies and current field activity AN - 51899564; 2004-007964 AB - The National Institute for Occupational Safety and Health (NIOSH) has continued the research role of the former U.S. Bureau of Mines to develop techniques that will reduce the hazards in the mining work place associated with coal bumps. Current research focuses on both analyzing historical seismic data from bump-prone operations and utilizing a mine-wide seismic network to investigate the exact strata failure mechanics associated with bump-prone geology. The anticipated outcome of this research will be reduced bump incidences through advanced engineering concepts and designs which implement the new understanding of strata behavior. The analysis of the historic seismic data consists of correlating observed mining seismicity with the geologic and geometric parameters at the sites. The primary seismic parameters are the timing, location and magnitude of a recorded seismic event. These parameters are correlated with such mining parameters as: the overburden, the size of the immediate gob, the size of the district gob area, etc. This detailed analysis of historical seismic data has provided an informative quantifiable relationship between many of the specific mining parameters and the induced seismicity. The second aspect of the coal bump research is the instrumentation of an appropriate field site to determine the main roof, floor, and gob behavior associated with bump behavior. The chosen field site is a deep-cover longwall mine with competent geology in a historically bump-prone area. The primary field instrumentation is a three-dimensional, full-waveform, seismic array with both surface and underground sensors surrounding an active multi-panel district. The purpose of this seismic array is to determine the timing, the exact location, and the mechanism (tensile fracture, bedding plane slip, etc.) of the failure of the strata surrounding the active and multi-panel gobs. The preliminary results presented in this paper help to define the strata failure areas around the longwall panel. JF - Proceedings - International Conference on Ground Control in Mining AU - Ellenberger, John L AU - Heasley, Keith A A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 112 EP - 120 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - mines KW - geologic hazards KW - three-dimensional models KW - regulations KW - coal mines KW - stability KW - sandstone KW - history KW - case studies KW - black shale KW - sedimentary rocks KW - safety KW - seismicity KW - rock bursts KW - coal KW - siltstone KW - seismic risk KW - clastic rocks KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51899564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Coal+mine+seismicity+and+bumps%3B+historical+case+studies+and+current+field+activity&rft.au=Ellenberger%2C+John+L%3BHeasley%2C+Keith+A&rft.aulast=Ellenberger&rft.aufirst=John&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 7 N1 - PubXState - WV N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - black shale; case studies; clastic rocks; coal; coal mines; geologic hazards; history; mines; regulations; rock bursts; safety; sandstone; sedimentary rocks; seismic risk; seismicity; siltstone; stability; three-dimensional models ER - TY - JOUR T1 - Analysis of safety aspects and mining practices for effective ground control in surface mining AN - 51898390; 2004-008003 AB - Fatalities caused by highwall/spoilbank failure in the surface mines, coal and non-metal, increased to an alarming rate of seven during 1999. To determine the causes of slope failure and successful mining practices, the National Institute for Occupational Health and Safety undertook a study. The study included: 1. A review of accident statistics; 2. A review of Federal and state mining laws pertaining to surface mining; 3. A literature review, and; 4. Mine visits. The study emphasized surface mines in the states of West Virginia, Ohio, and Pennsylvania. The review of a decade's accident statistics using the Mine Safety and Health Administration's (MSHA) database showed that approximately 40% of all ground control related incidents reported to MSHA occurred in just four eastern states: Kentucky, West Virginia, Pennsylvania, and Ohio. The comprehensive literature search provided a historical perspective of highwall stability issues. Eleven mines were visited to obtain data on their mining practice or design. Commodities included coal, sandstone, and limestone. Based on the visits, five case studies were developed to represent typical mining methods and effective ground control practices used in eastern surface mines. Benching was found to be a common technique to reduce the overall highwall slope angle. Decking in the softer zones, such as shale, proved useful in controlling damage due to blasting. JF - Proceedings - International Conference on Ground Control in Mining AU - Bhatt, Suresh K AU - Mark, Christopher A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 395 EP - 404 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - United States KW - rock masses KW - mining KW - shear strength KW - monitoring KW - surface mining KW - safety KW - Pennsylvania KW - slope stability KW - design KW - West Virginia KW - Ohio KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51898390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Analysis+of+safety+aspects+and+mining+practices+for+effective+ground+control+in+surface+mining&rft.au=Bhatt%2C+Suresh+K%3BMark%2C+Christopher&rft.aulast=Bhatt&rft.aufirst=Suresh&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 14 N1 - PubXState - WV N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - design; mining; monitoring; Ohio; Pennsylvania; rock masses; safety; shear strength; slope stability; surface mining; United States; West Virginia ER - TY - JOUR T1 - An approach to identifying geological properties from roof bolter drilling parameters AN - 51898239; 2004-007951 AB - Identifying the properties of overlying rocks in underground mining operations is important to ensure the appropriate roof support design is used to maintain stability of the mine entries. Recently J. H. Fletcher & Co. developed a monitoring and control system for roof bolters for the underground mining industry. The system records the drilling parameters used during roof bolt drilling and the information can provide insight into the physical properties of the roof strata. The parameters include thrust, rotational speed, torque and velocity and the measurements are collected every 0.1 second during the operation. The drilling parameters were analyzed to determine the application of identifying the strength of rocks being drilled from the measurements. The data was converted into the specific energy of drilling which is a measure of the amount of energy required for removing a given unit of rock during a drilling operation. The laboratory studies completed to data indicate a fairly high correlation between the specific energy of drilling and the unconfined compressive strength of the rocks that were drilled. Additionally, the drilling parameters were shown to be effective for identifying the presence of fractures or bed separations between rock layers. The thrust, torque and specific energy of drilling were all good indicators for identifying the fractures or separations. Regardless of the drilling parameters used during the drilling experiments, the location of the fractures were identified. In order to determine the application of the drilling parameters for identifying roof rock properties, two series of experiments were conducted. The first series of experiments used three "manufactured" roof layers that had various rock samples embedded in concrete blocks. The rock samples included three types of sandstone, marble, and argillite. Another concrete block was poured with foam inserts to simulate large bedding separations (2 to 8-in). Two other manufactured blocks were constructed using high-strength concrete with cardboard layers embedded to simulate smaller fractures or bedding separations. The size of the cardboard layers varied from 1/8-to 1-in thick. One of the blocks had the cardboard layers embedded at an inclined angle to determine the effect of the orientation on the drilling parameters. A series of experiments was conducted with the rotational speed and the penetration rate held constant and the thrust and torque allowed to vary. The information collected from the experiments is used to determine the application of the drilling parameter measurements for identifying rock properties, fractures and bedding separations. JF - Proceedings - International Conference on Ground Control in Mining AU - Finfinger, Gerald L AU - Peng, Syd S AU - Gu, Quanzhong AU - Wilson, Gene AU - Thomas, Bob A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 1 EP - 11 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - mining KW - argillite KW - engineering properties KW - roof control KW - weak rocks KW - stability KW - sandstone KW - tensile strength KW - elastic constants KW - rock mechanics KW - sedimentary rocks KW - mining geology KW - metamorphic rocks KW - marbles KW - drilling KW - compressive strength KW - competent materials KW - clastic rocks KW - Young's modulus KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51898239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=An+approach+to+identifying+geological+properties+from+roof+bolter+drilling+parameters&rft.au=Finfinger%2C+Gerald+L%3BPeng%2C+Syd+S%3BGu%2C+Quanzhong%3BWilson%2C+Gene%3BThomas%2C+Bob&rft.aulast=Finfinger&rft.aufirst=Gerald&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 12 N1 - PubXState - WV N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - argillite; clastic rocks; competent materials; compressive strength; drilling; elastic constants; engineering properties; marbles; metamorphic rocks; mining; mining geology; rock mechanics; roof control; sandstone; sedimentary rocks; stability; tensile strength; weak rocks; Young's modulus ER - TY - JOUR T1 - Development of stress measurement techniques in bump-prone coal for safety decisions AN - 51898146; 2004-007963 AB - Researchers at the Spokane Research Laboratory of the National Institute for Occupational Safety and Health are evaluating stress and displacement measurements in a longwall coal mine. The objective is to determine the best indicators of coal bump hazards during operations so that mine foremen and technical staff can make more informed intervention decisions to protect miners from coal bumps. Instruments were clustered in two panels, a yield pillar, and the immediate roof and floor of a two-entry longwall coal mine. Data were gathered continuously from a variety of instruments as mining proceeded toward and past the instrument cluster. Researchers and the mine's technical staff evaluated these data with respect to coal bumps and bump mechanisms. Selected graphs were then presented to mine foremen on a periodic basis to test their usefulness in identifying hazards. Of particular interest was the use of horizontal stress data from the immediate roof. To measure changes in horizontal stress, a new technique was developed for installing a grouted biaxial stressmeter in the roof. An evaluation of the development of this stress monitoring system in producing data beneficial to mine foremen is presented. JF - Proceedings - International Conference on Ground Control in Mining AU - Zahl, Eric G AU - Dunford, John P AU - Schissler, Andy AU - Larson, Mark K AU - Pierce, Paul A AU - Jones, F Mike A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 101 EP - 111 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - United States KW - mining KW - mines KW - Willow Creek Mine KW - monitoring KW - underground mining KW - biaxial tests KW - roof control KW - stress KW - data processing KW - coal mines KW - rock mechanics KW - measurement KW - sedimentary rocks KW - safety KW - mining geology KW - coal KW - Helper Utah KW - Utah KW - compressive strength KW - dilation KW - Carbon County Utah KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51898146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Development+of+stress+measurement+techniques+in+bump-prone+coal+for+safety+decisions&rft.au=Zahl%2C+Eric+G%3BDunford%2C+John+P%3BSchissler%2C+Andy%3BLarson%2C+Mark+K%3BPierce%2C+Paul+A%3BJones%2C+F+Mike&rft.aulast=Zahl&rft.aufirst=Eric&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 12 N1 - PubXState - WV N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - biaxial tests; Carbon County Utah; coal; coal mines; compressive strength; data processing; dilation; Helper Utah; measurement; mines; mining; mining geology; monitoring; pillars; rock mechanics; roof control; safety; sedimentary rocks; stress; underground mining; United States; Utah; Willow Creek Mine ER - TY - JOUR T1 - Utilizing the "advance and relieve" method to reduce horizontal stress affects on the mine roof, a case study AN - 51897328; 2004-007967 AB - A room and pillar coal operation in central Pennsylvania was experiencing roof cutters and long running roof falls caused by high horizontal stresses. The roof conditions created hazards for the miners, and caused several production panels to be abandoned prematurely. The mine requested assistance from the National Institute for Occupational Safety and Health (NIOSH) in applying the "advance and relieve" mining to reduce the affects of the horizontal stress during panel development. The "advance and relieve" plan that was developed called for removing a pillar on one side of the panel as it was being advanced, thus creating a cave. The caving then relieved a portion of the horizontal stress across the panel. Because the horizontal stress direction is key to the success of this method, stress mapping as well as mining experience was used to establish the direction of the horizontal stress. Subsequent field measurements provided an estimate of the stress magnitude. Three panels were mined using this technique, and good roof conditions were achieved in all these panels. Instrumentation was used to monitor the stress changes in the roof created by the cave. Stress relief of over 1,000 psi was measured 120 ft from the cave and to depths of 20 ft into the roof. The lateral extent of the stress relief zone across the panels appears to be about 400 to 500 ft. This case history has provided much insight into the practical application of the "advance and relieve" method discussed in this paper. JF - Proceedings - International Conference on Ground Control in Mining AU - Dolinar, Dennis R AU - Mucho, Thomas P AU - Oyler, David C AU - Pablic, Jim A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 137 EP - 148 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - United States KW - failures KW - monitoring KW - abutments KW - Pennsylvanian KW - Indiana County Pennsylvania KW - roof control KW - Paleozoic KW - Tanoma Mine KW - stress KW - Carboniferous KW - stability KW - sandstone KW - preventive measures KW - rock mechanics KW - Kittanning Formation KW - sedimentary rocks KW - mining geology KW - horizontal movements KW - Pennsylvania KW - clastic rocks KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51897328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Utilizing+the+%22advance+and+relieve%22+method+to+reduce+horizontal+stress+affects+on+the+mine+roof%2C+a+case+study&rft.au=Dolinar%2C+Dennis+R%3BMucho%2C+Thomas+P%3BOyler%2C+David+C%3BPablic%2C+Jim&rft.aulast=Dolinar&rft.aufirst=Dennis&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 17 N1 - PubXState - WV N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - abutments; Carboniferous; clastic rocks; failures; horizontal movements; Indiana County Pennsylvania; Kittanning Formation; mining geology; monitoring; Paleozoic; Pennsylvania; Pennsylvanian; pillars; preventive measures; rock mechanics; roof control; sandstone; sedimentary rocks; stability; stress; Tanoma Mine; United States ER - TY - JOUR T1 - Using the point load test to determine the uniaxial compressive strength of coal measure rock AN - 51896729; 2004-007999 AB - Point load testing is used to determine rock strength indexes in geotechnical practice. The point load test apparatus and procedure enables economical testing of core or lump rock samples in either a field or laboratory setting. In order to estimate uniaxial compressive strength, index-to-strength conversion factors are used. These factors have been proposed by various researchers and are dependent upon rock type. This study involved the extensive load frame and point load testing of coal measure rocks in six states. More than 10,000 individual test results, from 908 distinct rock units, were used in the study. Rock lithologies were classified into general categories and conversion factors were determined for each category. This allows for intact rock strength data to be made available through point load testing for numerical geotechnical analysis and empirical rock mass classification systems such as the Coal Mine Roof Rating (CMRR). JF - Proceedings - International Conference on Ground Control in Mining AU - Rusnak, John A AU - Mark, Christopher A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 362 EP - 371 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - limestone KW - shale KW - sandstone KW - quartzites KW - mathematical models KW - uniaxial tests KW - rock mechanics KW - sedimentary rocks KW - claystone KW - coal KW - siltstone KW - metamorphic rocks KW - load tests KW - compressive strength KW - carbonate rocks KW - clastic rocks KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51896729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Using+the+point+load+test+to+determine+the+uniaxial+compressive+strength+of+coal+measure+rock&rft.au=Rusnak%2C+John+A%3BMark%2C+Christopher&rft.aulast=Rusnak&rft.aufirst=John&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 19 N1 - PubXState - WV N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - carbonate rocks; clastic rocks; claystone; coal; compressive strength; limestone; load tests; mathematical models; metamorphic rocks; quartzites; rock mechanics; sandstone; sedimentary rocks; shale; siltstone; uniaxial tests ER - TY - JOUR T1 - Optimizing secondary roof support with the NIOSH support technology optimization program (STOP) AN - 51896586; 2004-007960 AB - The decade of the 90's brought an unprecedented increase in the development of innovative technologies to provide more effective and easier to install roof support in underground mines. To facilitate the application of these technologies to improve mine safety, National Institute for Occupational Safety and Health (NIOSH) developed the Support Technology Optimization Program (STOP). STOP is a window's based software program that provides mine operators with a simple and practical tool to make engineering decisions regarding the selection and placement strategy of these various standing roof support technologies. This program includes a complete data base of the support characteristics and loading profiles obtained through safety performance testing of these supports at the NIOSH Safety Structures Testing Laboratory. Support design criteria in the form of the required support load density at a specified convergence can be established from four options: (1) a data base of measured ground reaction data from various mines or ground behavior information inputted by the user, (2) determination of loading requirements based on a detached roof block or rock failure height, or (3) criteria based on the current roof support system, and (4) arbitrary criteria set the by user. Using these design criteria, the program will determine the installation requirements for a particular support technology that will provide the necessary support load density and convergence control. Optimization routines are also available to determine the most efficient support design for a user specified support installation. In addition to these performance measures, STOP can be used to compare material handling requirements and installation costs. Comparisons among the various support technologies are easily made including graphical analysis of relevant support parameters. This paper describes the STOP and its application to optimize standing secondary roof support systems. JF - Proceedings - International Conference on Ground Control in Mining AU - Barczak, Thomas M A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 74 EP - 83 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - mining KW - underground mining KW - roof control KW - regulations KW - data processing KW - stability KW - optimization KW - rock mechanics KW - computer programs KW - safety KW - mining geology KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51896586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Optimizing+secondary+roof+support+with+the+NIOSH+support+technology+optimization+program+%28STOP%29&rft.au=Barczak%2C+Thomas+M&rft.aulast=Barczak&rft.aufirst=Thomas&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 7 N1 - PubXState - WV N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - computer programs; data processing; mining; mining geology; optimization; pillars; regulations; rock mechanics; roof control; safety; stability; underground mining ER - TY - JOUR T1 - Roof monitoring in limestone mines; experience with the roof monitoring safety system (RMSS) AN - 51895189; 2004-007973 AB - During the past few years, the Pittsburgh Research Laboratory of the National Institute for Occupational Safety and Health (NIOSH) examined and characterized conditions at a majority of the underground stone mines in the United States. Observations at these mines revealed a limited degree of roof monitoring beyond visual inspection and sounding. When monitors are used, they typically require the miner to measure movement at the roof. If conditions are unstable, the miner may be in a hazardous situation while recording data. Based on this scenario, researchers surmised that a simple, inexpensive monitor with the capability of recording data at a distance from the mine roof would be a safer way to gain the information. Additionally, more widespread use of monitors could potentially lead to better understanding of roof movement in general. A monitor to meet this need was designed, tested, and subsequently improved as experience was gained in its' use at a number of underground stone mines. The Roof Monitoring Safety System (RMSS) can provide an initial indication of movement in roof beams. By understanding and measuring roof movement in underground mines, the potential for injuries and fatalities to mine workers from falls of ground can be reduced. Also, officials at a mine with a history of data are better prepared to make a decision on remedial actions in the event of ground falls. This paper will outline the evolution of the RMSS and how it can be used in a comprehensive pro-active ground control safety program. Also included is a case history describing how the RMSS was used in an evaluation of the effectiveness of a mechanical impact scaling machine at an operating limestone mine. JF - Proceedings - International Conference on Ground Control in Mining AU - Marshall, Thomas E AU - Prosser, Lou J AU - Iannacchione, Anthony AU - Dunn, Michael A2 - Peng, Syd S. A2 - Mark, Christopher Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 185 EP - 191 PB - West Virginia University, College of Mineral and Energy Resources, Dep. of Mining Engineering, Morgantown, WV VL - 19 KW - limestone KW - mining KW - mines KW - monitoring KW - roof control KW - stability KW - mechanical properties KW - information management KW - rock mechanics KW - data management KW - sedimentary rocks KW - safety KW - cracks KW - mining geology KW - carbonate rocks KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51895189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.atitle=Roof+monitoring+in+limestone+mines%3B+experience+with+the+roof+monitoring+safety+system+%28RMSS%29&rft.au=Marshall%2C+Thomas+E%3BProsser%2C+Lou+J%3BIannacchione%2C+Anthony%3BDunn%2C+Michael&rft.aulast=Marshall&rft.aufirst=Thomas&rft.date=2000-08-01&rft.volume=19&rft.issue=&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Ground+Control+in+Mining&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 19th international conference on Ground control in mining N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 5 N1 - PubXState - WV N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #03299 N1 - SubjectsTermNotLitGenreText - carbonate rocks; cracks; data management; information management; limestone; mechanical properties; mines; mining; mining geology; monitoring; rock mechanics; roof control; safety; sedimentary rocks; stability ER - TY - JOUR T1 - Serotype distribution and antimicrobial resistance patterns of invasive isolates of Streptococcus pneumoniae: Alaska, 1991-1998 AN - 18088194; 5182513 AB - From January 1991 through December 1998, a total of 1046 pneumococcal isolates were received from 23 laboratories participating in the statewide surveillance system. Of these, 1037 were recovered from normally sterile sites (blood and cerebrospinal and pleural fluid) and were available for serotyping and susceptibility testing. Ninety-two percent of these isolates were serotypes represented in the 23-valent pneumococcal polysaccharide vaccine. Serotypes in the 7-valent pneumococcal conjugate vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F) were recovered from 72% of Alaska Natives and 84% of non-Native children <5 years old with invasive disease. Statewide, 7.3% and 3.2% of isolates had intermediate and high levels of resistance to penicillin, respectively; 9.2% were resistant to erythromycin (minimal inhibitory concentration, greater than or equal to 1 mu g/mL) and 19% to trimethoprim/sulfamethoxazole (minimal inhibitory concentration, greater than or equal to 4/76 mu g/mL). Twelve percent of invasive isolates were resistant to greater than or equal to 2 classes of antibiotics; of these, serotype 6B accounted for 33%, and 63% were recovered from children <5 years old. JF - Journal of Infectious Diseases AU - Rudolph, K M AU - Parkinson, A J AU - Reasonover, AL AU - Bulkow, L R AU - Parks, D J AU - Butler, J C AD - Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Anchorage, Alaska Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 490 EP - 496 VL - 182 IS - 2 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - USA, Alaska KW - Trimethoprim KW - Serotypes KW - Sulfamethoxazole KW - Drug resistance KW - Erythromycin KW - Penicillin KW - Streptococcus pneumoniae KW - Antibacterial agents KW - A 01064:Microbial resistance KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18088194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Serotype+distribution+and+antimicrobial+resistance+patterns+of+invasive+isolates+of+Streptococcus+pneumoniae%3A+Alaska%2C+1991-1998&rft.au=Rudolph%2C+K+M%3BParkinson%2C+A+J%3BReasonover%2C+AL%3BBulkow%2C+L+R%3BParks%2C+D+J%3BButler%2C+J+C&rft.aulast=Rudolph&rft.aufirst=K&rft.date=2000-08-01&rft.volume=182&rft.issue=2&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; USA, Alaska; Serotypes; Antibacterial agents; Drug resistance; Penicillin; Erythromycin; Trimethoprim; Sulfamethoxazole ER - TY - JOUR T1 - Keeping Eggs Safe from Farm to Table AN - 17817063; 4858572 AB - Last year, the President's Council on Food Safety identified egg safety as a public health issue that warrants immediate action by the Food and Drug Administration (FDA) and the U.S. Dept. of Agriculture's Food Safety and Inspection Service (FSIS), which share federal regulatory responsibility for egg safety. In response, the agencies developed and announced in December 1999 an action plan entitled "Egg Safety From Production to Consumption: An Action Plan to Eliminate Salmonella enteritidis Illnesses Due to Eggs." The goal of the action plan is to reduce and ultimately eliminate eggs as a source of human S. enteritidis illnesses. An interim goal is to achieve a 50% reduction in egg-associated S. enteritidis illnesses by 2005. JF - Food Technology AU - Bufano, N S AD - Food and Drug Administration, 200 C St., S.W., Washington, DC 20204, USA Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 192 VL - 54 IS - 8 SN - 0015-6639, 0015-6639 KW - FDA KW - Salmonella enteritidis KW - USA KW - food-borne diseases KW - Health & Safety Science Abstracts KW - Food contamination KW - Eggs KW - Public health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17817063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Technology&rft.atitle=Keeping+Eggs+Safe+from+Farm+to+Table&rft.au=Bufano%2C+N+S&rft.aulast=Bufano&rft.aufirst=N&rft.date=2000-08-01&rft.volume=54&rft.issue=8&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Food+Technology&rft.issn=00156639&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Public health; Food contamination; Eggs ER - TY - JOUR T1 - Finite Element Modeling of ROPS in Static Testing and Rear Overturns AN - 17815977; 4847765 AB - Even with the technological advances of the last several decades, agricultural production remains one of the most hazardous occupations in the United States. Death due to tractor rollover is a prime contributor to this hazard. Standards for rollover protective structures (ROPS) performance and certification have been developed by groups such as the Society of Automotive Engineers (SAE) and the American Society of Agricultural Engineers (ASAE) to combat these problems. The current ROPS certification standard, SAE J2194, requires either a dynamic or static testing sequence or both. Although some ROPS manufacturers perform both the dynamic and static phases of SAE J2194 testing, it is possible for a ROPS to be certified for field operation using static testing alone. This research compared ROPS deformation response from a simulated SAE J2194 static loading sequence to ROPS deformation response as a result of a simulated rearward tractor rollover. Finite element analysis techniques for plastic deformation were used to simulate both the static and dynamic rear rollover scenarios. Stress results from the rear rollover model were compared to results from simulated static testing per SAE J2194. Maximum stress values from simulated rear rollovers exceeded maximum stress values recorded during simulated static testing for half of the elements comprising the uprights. In the worst case, the static model underpredicts dynamic model results by approximately 7%. In the best case, the static model overpredicts dynamic model results by approximately 32%. These results suggest the need for additional experimental work to characterize ROPS stress levels during staged overturns and during testing according to the SAE standard. JF - Journal of Agricultural Safety and Health AU - Harris, J R AU - Mucino, V H AU - Etherton, J R AU - Snyder, KA AU - Means, KH AD - NIOSH, Division of Safety Research, 1095 Willowdale Road, M/S 119, Morgantown, WV 26505, USA, jharris@cdc.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 215 EP - 225 VL - 6 IS - 3 SN - 1074-7583, 1074-7583 KW - USA KW - farming KW - rollover protective structures KW - tractors KW - Health & Safety Science Abstracts KW - Agriculture KW - Occupational safety KW - Simulation KW - Standards KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17815977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Finite+Element+Modeling+of+ROPS+in+Static+Testing+and+Rear+Overturns&rft.au=Harris%2C+J+R%3BMucino%2C+V+H%3BEtherton%2C+J+R%3BSnyder%2C+KA%3BMeans%2C+KH&rft.aulast=Harris&rft.aufirst=J&rft.date=2000-08-01&rft.volume=6&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; Agriculture; Standards; Simulation ER - TY - JOUR T1 - Job Hazards for Musculoskeletal Disorders for Youth Working on Farms AN - 17814785; 4847763 AB - A series of eight focus groups were convened to: (1) identify tasks and activities performed by youth on farms with the potential for causing non-traumatic work-related Musculoskeletal Disorders (MSDs); (2) determine the participants perceptions about risks of MSDs for youths performing those tasks; and (3) determine other factors that might relate to MSDs for youth working on farms, such as possible interventions for prevention. Seventy-two farm family members, 40 adults and 32 farm youth aged 8-18, participated in focus groups. Ten questions were posed to each of the eight groups about what tasks youth perform on the farm, how the work is assigned, and what risk factors are associated with the work. There was general agreement among the adults that maturity rather than age is the dominant factor for determining what tasks are performed by youth workers on the farm. Youth, on the other hand, believed that task urgency dictated what jobs were assigned to youth workers. Most adults indicated that lifting objects, forking, or shoveling was responsible for most of the serious non-traumatic injuries. Bending over while working, sitting in an awkward position looking back at equipment from a tractor, sitting in a cramped position, looking down at a combine header, and long hours of work were also identified as potential problems. Youth described muscle aches and strains of the legs, arms, shoulder, back or neck as everyday occurrences. According to the youth, "If it's not broken, you're fine". Only basic training is provided and most respondents believed that youth learned best through observation. There was general agreement that physician recommended guidelines for assigning youth to tasks would be ignored unless they carried the force of the law. JF - Journal of Agricultural Safety and Health AU - Bartels, S AU - Niederman, B AU - Waters, T R AD - National Institute for Occupational Safety and Health (MS C-24), 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, trw1@cdc.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 191 EP - 201 VL - 6 IS - 3 SN - 1074-7583, 1074-7583 KW - farming KW - lifting KW - musculoskeletal system KW - Health & Safety Science Abstracts KW - Agriculture KW - Injuries KW - Materials handling KW - Children KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17814785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Job+Hazards+for+Musculoskeletal+Disorders+for+Youth+Working+on+Farms&rft.au=Bartels%2C+S%3BNiederman%2C+B%3BWaters%2C+T+R&rft.aulast=Bartels&rft.aufirst=S&rft.date=2000-08-01&rft.volume=6&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational health; Children; Agriculture; Injuries; Materials handling ER - TY - JOUR T1 - Recalls of Foods and Cosmetics Due to Microbial Contamination Reported to the U.S. Food and Drug Administration AN - 17808006; 4848696 AB - In the U.S., food product recalls serve as an important intervention in stemming the consumption of food products contaminated with infectious disease agents. We summarize the number and nature of foods and cosmetics recalled as a result of microbial contamination reported to the U.S. Food and Drug Administration (FDA) for the period 1 October 1993 through 30 September 1998. During this period, microbial contamination of food and cosmetic products was the leading cause for recalls, accounting for a total of 1,370 recalls (36% of all products recalled). Listeria monocytogenes accounted for the greatest number of food products recalled because of microbial contamination, whereas Pseudomonas aeruginosa was the most common microbe associated with recalls of cosmetic products. Dairy products, followed by seafood and pastry items, were the types of products most often associated with recalls due to microbial contamination. The FDA was the entity most often responsible for detecting microbial contamination of foods and cosmetics (33% of all such recalls), followed by state regulatory agencies (24%), and manufacturers/retailers (21%). Nineteen percent of recalls were associated with at least one reported case of illness. Salmonella was the pathogen most often implicated in reports of illness associated with these recalled products. JF - Journal of Food Protection AU - Wong, S AU - Street, D AU - Delgado, SI AU - Klontz, K C AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, D.C. 20204, USA, kdk@bangate.fda.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 1113 EP - 1116 VL - 63 IS - 8 SN - 0362-028X, 0362-028X KW - FDA KW - Listeria monocytogenes KW - Pseudomonas aeruginosa KW - USA KW - cosmetics KW - recalls KW - Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Reviews KW - Cosmetics KW - Food contamination KW - A 01017:Human foods KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17808006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Recalls+of+Foods+and+Cosmetics+Due+to+Microbial+Contamination+Reported+to+the+U.S.+Food+and+Drug+Administration&rft.au=Wong%2C+S%3BStreet%2C+D%3BDelgado%2C+SI%3BKlontz%2C+K+C&rft.aulast=Wong&rft.aufirst=S&rft.date=2000-08-01&rft.volume=63&rft.issue=8&rft.spage=1113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pseudomonas aeruginosa; Listeria monocytogenes; Reviews; Food contamination; Cosmetics ER - TY - JOUR T1 - Evaluation of Percutaneous Penetration of Natural Rubber Latex Proteins AN - 17738078; 4796624 AB - Latex allergy is recognized worldwide as a serious health risk. To date, exposure assessment and intervention strategies have focused primarily on respiratory protection; this work evaluates the potential role of dermal protein penetration in the development of latex allergy. In vitro penetration models using flow-through diffusion cells and both human surgical specimens and hairless guinea pig skin (CrL: IAF/HA) demonstrated iodinated latex proteins (ammoniated and non-ammoniated) penetrating into and through both intact and abraded skin. Although less than 1% penetration was observed with intact skin, up to 23% of latex proteins applied to abraded skin were recovered from receptor fluid within 24 h of exposure. Phosphoimaging of the concentrated effluent revealed proteins ranging in size from 3 to 26 kDa. Using a super(3)H sub(2)O penetration assay to evaluate barrier integrity, the amount of latex protein penetration was found to positively correlate with the degree of dermabrasion. Immunohistochemistry of the skin localized latex proteins in the Langerhans cell-rich epidermis and in the dermis. Both in vitro penetration studies and immunohistochemistry supported the use of hairless guinea pig skin as a surrogate for human skin in evaluating latex protein penetration. In studies performed in vivo, 35% of hairless guinea pigs topically exposed to latex proteins (100 mu g) 5 days per week for 3 months demonstrated elevations in latex-specific IgG1. The implication for these data is that the skin is not only a plausible route for latex sensitization but can be a major exposure route when the integument has been compromised. JF - Toxicological Sciences AU - Hayes, B B AU - Afshari, A AU - Millecchia, L AU - Willard, P A AU - Povoski, S P AU - Meade, B J AD - National Institute for Occupational Safety and Health, MS 4020, 1095 Willowdale Road, Morgantown, WV 26505, USA Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 262 EP - 270 VL - 56 IS - 2 SN - 1096-6080, 1096-6080 KW - chronic exposure KW - guinea-pigs KW - immunoglobulin G1 KW - Toxicology Abstracts KW - Skin KW - Allergens KW - Sensitization KW - Proteins KW - Rubber KW - Latex KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17738078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Evaluation+of+Percutaneous+Penetration+of+Natural+Rubber+Latex+Proteins&rft.au=Hayes%2C+B+B%3BAfshari%2C+A%3BMillecchia%2C+L%3BWillard%2C+P+A%3BPovoski%2C+S+P%3BMeade%2C+B+J&rft.aulast=Hayes&rft.aufirst=B&rft.date=2000-08-01&rft.volume=56&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Rubber; Latex; Proteins; Allergens; Sensitization ER - TY - JOUR T1 - Quantitative Comparisons of in Vitro Assays for Estrogenic Activities AN - 17727514; 4796919 AB - Substances that may act as estrogens show a broad chemical structural diversity. To thoroughly address the question of possible adverse estrogenic effects, reliable methods are needed to detect and identify the chemicals of these diverse structural classes. We compared three assays - in vitro estrogen receptor competitive binding assays (ER binding assays), yeast-based reporter gene assays (yeast assays), and the MCF-7 cell proliferation assay (E-SCREEN assay) - to determine their quantitative agreement in identifying structurally diverse estrogens. We examined assay performance for relative sensitivity, detection of active/inactive chemicals, and estrogen/antiestrogen activities. In this examination, we combined individual data sets in a specific, quantitative data mining exercise. Data sets for at least 29 chemicals from five laboratories were analyzed pair-wise by X-Y plots. The ER binding assay was a good predictor for the other two assay results when the antiestrogens were excluded (r super(2) is 0.78 for the yeast assays and 0.85 for the E-SCREEN assays). Additionally, the examination strongly suggests that biologic information that is not apparent from any of the individual assays can be discovered by quantitative pair-wise comparisons among assays. Antiestrogens are identified as outliers in the ER binding/yeast assay, while complete antagonists are identified in the ER binding and E-SCREEN assays. Furthermore, the presence of outliers may be explained by different mechanisms that induce an endocrine response, different impurities in different batches of chemicals, different species sensitivity, or limitations of the assay techniques. Although these assays involve different levels of biologic complexity, the major conclusion is that they generally provided consistent information in quantitatively determining estrogenic activity for the five data sets examined. The results should provide guidance for expanded data mining examinations and the selection of appropriate assays to screen estrogenic endocrine disruptors. JF - Environmental Health Perspectives AU - Fang, Hong AU - Tong, W AU - Perkins, R AU - Soto, A M AU - Prechtl, N V AU - Sheehan, D M AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), 3900 NCTR Road, Jefferson, AR 72079, USA, hfang@nctr.fda.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 723 EP - 729 VL - 108 IS - 8 SN - 0091-6765, 0091-6765 KW - ER binding assay KW - E-SCREEN assay KW - bioassays KW - estrogen receptors KW - estrogens KW - reporter gene KW - yeasts KW - Toxicology Abstracts KW - Cell proliferation KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17727514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Quantitative+Comparisons+of+in+Vitro+Assays+for+Estrogenic+Activities&rft.au=Fang%2C+Hong%3BTong%2C+W%3BPerkins%2C+R%3BSoto%2C+A+M%3BPrechtl%2C+N+V%3BSheehan%2C+D+M&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2000-08-01&rft.volume=108&rft.issue=8&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell proliferation ER - TY - JOUR T1 - Regulatory Action Criteria for Filth and Other Extraneous Materials AN - 17688259; 4772061 AB - Under Section 402(a)(3) of the Food, Drug and Cosmetic Act the distribution of foods which may contain repulsive or offensive matter, considered as filth, is prohibited. Filth includes contaminants such as rat, mouse, and other animal hairs and excreta; whole insects, insect parts, and excreta; and other extraneous materials which, because of their repulsiveness, would not knowingly be eaten or used. The presence of such filth renders food adulterated. Some foods, even when produced under good manufacturing practice, contain low levels of natural or unavoidable defects such as dirt, insect parts, and hair that are not hazardous to health. Although the health hazard is eliminated, most consumers find the presence of "any" visible filth contaminant such as hair in a food product objectionable. The objective of this study was to determine when a defect (hair) in a food (mushrooms) is visible to a consumer by testing the visual acuity of a consumer panel under controlled laboratory conditions. Of the panelists participating in the study, when presented with a single hair on a flat surface with a solid-colored background, 27% were able to detect a 1-mm hair, 58% were able to detect a 3-mm hair, and 75% were able to detect a 10-mm hair. Twenty-five percent of the panelists surveyed were able to detect a 5- or 10-mm hair on sliced, canned mushrooms. The experimental design and results of this study are discussed. JF - Regulatory Toxicology and Pharmacology AU - Valdes Biles, P AU - Ziobro, G C AD - Microanalytical Branch, U.S. Food and Drug Administration, HFS-315, 200 C Street S.W., Washington, 20204, DC Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 73 EP - 77 PB - Academic Press VL - 32 IS - 1 SN - 0273-2300, 0273-2300 KW - panel evaluation KW - filth KW - man KW - Toxicology Abstracts KW - Government policy KW - Food contamination KW - Hair KW - Legislation KW - X 24120:Food, additives & contaminants KW - X 24230:Legislation & recommended standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17688259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Regulatory+Action+Criteria+for+Filth+and+Other+Extraneous+Materials&rft.au=Valdes+Biles%2C+P%3BZiobro%2C+G+C&rft.aulast=Valdes+Biles&rft.aufirst=P&rft.date=2000-08-01&rft.volume=32&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Government policy; Legislation; Food contamination; Hair ER - TY - JOUR T1 - Bartonella henselae, B. quintana, and B. bacilliformis: historical pathogens of emerging significance AN - 17637724; 4776746 AB - Bartonella species were virtually unrecognized as modern pathogens of humans until the last decade. However, identification of Bartonella species as the agents of cat-scratch disease, bacillary angiomatosis, urban trench fever, and possible novel presentations of Carrion's disease has left little doubt of the emerging medical importance of this genus of organisms. The three primary human pathogenic bartonellae, Bartonella hacilliformis (Carrion's disease), B. henselae (cat-scratch disease), and B. quintana (trench fever), present noteworthy comparisons in the epidemiology, natural history, pathology, and host-microbe interaction that this review will briefly explore. JF - Microbes and Infection AU - Karem, K L AU - Paddock, C D AU - Regnery, R L AD - Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Departmemt of Health and Human Services, Atlanta, GA 30333, USA Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 1193 EP - 1205 VL - 2 IS - 10 SN - 1286-4579, 1286-4579 KW - man KW - Microbiology Abstracts B: Bacteriology KW - Reviews KW - Bartonella henselae KW - Pathogens KW - Bartonella bacilliformis KW - Bartonella quintana KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17637724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Bartonella+henselae%2C+B.+quintana%2C+and+B.+bacilliformis%3A+historical+pathogens+of+emerging+significance&rft.au=Karem%2C+K+L%3BPaddock%2C+C+D%3BRegnery%2C+R+L&rft.aulast=Karem&rft.aufirst=K&rft.date=2000-08-01&rft.volume=2&rft.issue=10&rft.spage=1193&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2FS1286-4579%2800%2901273-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bartonella henselae; Bartonella quintana; Bartonella bacilliformis; Reviews; Pathogens DO - http://dx.doi.org/10.1016/S1286-4579(00)01273-9 ER - TY - JOUR T1 - Transformation of Amoxapine by Cunninghamella elegans AN - 17615767; 4759736 AB - We examined Cunninghamella elegans to determine its ability to transform amoxapine, a tricyclic antidepressant belonging to the dibenzoxazepine class of drugs. Approximately 57% of the exogenous amoxapine was metabolized to three metabolites that were isolated by high-performance liquid chromatography and were identified by nuclear magnetic resonance and mass spectrometry as 7-hydroxyamoxapine (48%), N-formyl-7-hydroxyamoxapine (31%), and N-formylamoxapine (21%). 7-Hydroxyamoxapine, a mammalian metabolite with biological activity, now can be produced in milligram quantities for toxicological evaluation. JF - Applied and Environmental Microbiology AU - Moody, J D AU - Zhang, D AU - Heinze, T M AU - Cerniglia, CE AD - Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA, CCerniglia@nctr.fda.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 3646 EP - 3649 VL - 66 IS - 8 SN - 0099-2240, 0099-2240 KW - metabolism KW - 7-Hydroxyamoxapine KW - Amoxapine KW - N-Formyl-7-hydroxyamoxapine KW - N-Formylamoxapine KW - dibenzoxazepine KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Antidepressants KW - N.M.R. KW - Cunninghamella elegans KW - Mass spectroscopy KW - A 01014:Others KW - W2 32580:Fermentation and process engineering KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17615767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Transformation+of+Amoxapine+by+Cunninghamella+elegans&rft.au=Moody%2C+J+D%3BZhang%2C+D%3BHeinze%2C+T+M%3BCerniglia%2C+CE&rft.aulast=Moody&rft.aufirst=J&rft.date=2000-08-01&rft.volume=66&rft.issue=8&rft.spage=3646&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.8.3646-3649.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cunninghamella elegans; High-performance liquid chromatography; Antidepressants; N.M.R.; Mass spectroscopy DO - http://dx.doi.org/10.1128/AEM.66.8.3646-3649.2000 ER - TY - JOUR T1 - Human cancer risk and exposure to 1,3-butadiene -- a tale of mice and men AN - 17040990; 4762030 AB - The purpose of this study was to evaluate empirically the relevance of animal-bioassay-based models for predicting human risks from exposure to 1,3-butadiene (BD) using epidemiologic data. Relative-risk results obtained with a regression model in a recent epidemiologic study were used to estimate leukemia risk for occupational and environmental exposures to BD and to compare these estimates with those previously derived from an analysis of animal bioassay data. The estimates of risk were found to be highly dependent on the model used when low levels of exposure were evaluated that are of environmental concern, but not at the levels of occupational concern. For example, at the level (1 part per million) of the recently revised standard of the Occupational Safety and Health Administration in the United States the estimates of lifetime excess risk ranged from 1 to 8 per 1000 workers. The range of the risk estimates derived from the epidemiologic models was remarkably similar to the range of risk estimates for occupational exposures (1 to 9 per thousand) previously developed by Dankovic et al in 1993 from an analysis of a mouse bioassay study for lymphocytic lymphoma. Results for BD seem to provide another example of a high degree of concordance between the risk predictions from models of toxicologic and epidemiologic data, particularly at occupational levels of exposure. JF - Scandinavian Journal of Work, Environment & Health AU - Stayner, L T AU - Dankovic, DA AU - Smith, R J AU - Gilbert, S J AU - Bailer, J AD - National Institute for Occupational Safety and Health C15, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, lts2@cdc.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 322 EP - 330 VL - 26 IS - 4 SN - 0355-3140, 0355-3140 KW - man KW - 1,3-butadiene KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Animal models KW - 1,3-Butadiene KW - Bioassays KW - Carcinogenesis KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17040990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Human+cancer+risk+and+exposure+to+1%2C3-butadiene+--+a+tale+of+mice+and+men&rft.au=Stayner%2C+L+T%3BDankovic%2C+DA%3BSmith%2C+R+J%3BGilbert%2C+S+J%3BBailer%2C+J&rft.aulast=Stayner&rft.aufirst=L&rft.date=2000-08-01&rft.volume=26&rft.issue=4&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bioassays; Animal models; Occupational exposure; Carcinogenesis; 1,3-Butadiene; Risk assessment ER - TY - CONF T1 - Role of inflammation in chemical-induced hepatotoxicity AN - 17900955; 5166547 AB - The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators that can effect liver damage or repair. This review will summarize our current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride, an industrial chemical, and acetaminophen, a widely used analgesic. JF - Toxicology Letters AU - Luster, MI AU - Simeonova, P P AU - Gallucci, R M AU - Bruccoleri, A AU - Blazka, ME AU - Yucesoy, B Y1 - 2000/07/27/ PY - 2000 DA - 2000 Jul 27 SP - 317 EP - 321 PB - Elsevier Science Ireland Ltd., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 116 IS - 1-2 KW - Toxicology Abstracts KW - Carbon tetrachloride KW - Reviews KW - Drug metabolism KW - Liver KW - Chemical pollution KW - Acetaminophen KW - Inflammation KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17900955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Role+of+inflammation+in+chemical-induced+hepatotoxicity&rft.au=Luster%2C+MI%3BSimeonova%2C+P+P%3BGallucci%2C+R+M%3BBruccoleri%2C+A%3BBlazka%2C+ME%3BYucesoy%2C+B&rft.aulast=Luster&rft.aufirst=MI&rft.date=2000-07-27&rft.volume=116&rft.issue=1-2&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Dopamine toxicity following long term exposure to low doses of 3-nitropropionic acid (3-NPA) in rats AN - 17621239; 4755837 AB - A toxin produced by legumes of the genus Astragalus and Arthrinium fungi, 3-NPA is a suicide inhibitor of succinate dehydrogenase and causes acute encephalopathy and late onset dystonia. It has been suggested that dopamine (DA) toxicity plays a role in 3-NPA induced brain damage. In order to simulate natural conditions of toxicant intake, adult, male, Sprague-Dawley rats were exposed to 3-NPA weekly for 24-h periods at 10 and 20 mg/40 ml in drinking water. This dosing regimen continued for 3 months with animals from both high and low dose groups sacrificed at the end of each month. Dopamine and its metabolites, 3,4-dihydroxylphenylacetic acid (DOPAC) and homovanillic acid (HVA), were assessed by HPLC-EC in the frontal cortex (FC) and caudate nucleus (CN). Increases of DA concentration were seen in both low and high dose groups in the CN after 1 and 3 months of dosing and in the FC after 2 months of exposure. An increase in DA turnover was observed in the CN of the high dose group following 2 months of dosing. Data suggest an activation of the dopaminergic system after long-term, intermittent exposure to 3-NPA. The production of radical oxygen species associated with DA metabolism may contribute to 3-NPA-induced neurotoxicity. JF - Toxicology Letters AU - Johnson, J R AU - Robinson, B L AU - Ali, S F AU - Binienda, Z AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA, zbinienda@nctr.fda.gov Y1 - 2000/07/27/ PY - 2000 DA - 2000 Jul 27 SP - 113 EP - 118 VL - 116 IS - 1-2 SN - 0378-4274, 0378-4274 KW - rats KW - 3-nitropropionic acid KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Arthrinium KW - Fungi KW - Free radicals KW - Astragalus KW - Oxygen KW - Mycotoxins KW - Dopamine KW - Reactive oxygen species KW - Legumes KW - Neurotoxicity KW - N3 11104:Mammals (except primates) KW - X 24172:Plants KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17621239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Dopamine+toxicity+following+long+term+exposure+to+low+doses+of+3-nitropropionic+acid+%283-NPA%29+in+rats&rft.au=Johnson%2C+J+R%3BRobinson%2C+B+L%3BAli%2C+S+F%3BBinienda%2C+Z&rft.aulast=Johnson&rft.aufirst=J&rft.date=2000-07-27&rft.volume=116&rft.issue=1-2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2FS0378-4274%2800%2900214-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Astragalus; Arthrinium; Neurotoxicity; Dopamine; Legumes; Free radicals; Oxygen; Mycotoxins; Fungi; Reactive oxygen species DO - http://dx.doi.org/10.1016/S0378-4274(00)00214-9 ER - TY - JOUR T1 - Overview of immunotoxicology and current applications to respiratory diseases. AN - 72216031; 10960674 AB - Immunotoxicology has been defined as the study of adverse effects on the immune system resulting directly from environmental, occupational, or therapeutic exposure to chemicals (including drugs), biological materials and, in certain instances, physiological factors, collectively referred to as agents. It encompasses immunosuppression, allergy, autoimmunity and inflammation. JF - Immunopharmacology AU - Luster, M I AU - Simeonova, P AU - Gallucci, R AU - Matheson, J AU - Yucesoy, B AU - Sugawara, T AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. Y1 - 2000/07/25/ PY - 2000 DA - 2000 Jul 25 SP - 311 EP - 313 VL - 48 IS - 3 SN - 0162-3109, 0162-3109 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Risk Assessment KW - Lung -- immunology KW - Respiratory Hypersensitivity -- diagnosis KW - Immunotoxins -- immunology KW - Respiratory Hypersensitivity -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72216031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology&rft.atitle=Overview+of+immunotoxicology+and+current+applications+to+respiratory+diseases.&rft.au=Luster%2C+M+I%3BSimeonova%2C+P%3BGallucci%2C+R%3BMatheson%2C+J%3BYucesoy%2C+B%3BSugawara%2C+T&rft.aulast=Luster&rft.aufirst=M&rft.date=2000-07-25&rft.volume=48&rft.issue=3&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology&rft.issn=01623109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Microbial risk assessment: dose-response relations and risk characterization. AN - 71747899; 10939266 AB - Characterizations of the risks associated with foodborne pathogens are dependent on the availability of information on the population's exposure to the biological agents. However, by itself, exposure data are insufficient to assess the public health impact of pathogenic microorganisms. This requires the availability of effective dose-response models. Successful development of models that describe dose-response relations for enteric pathogens is dependent on a sound understanding of the mechanisms of pathogenicity associated with individual pathogens. This includes knowledge of how the various pathogen, host, and food matrix factors influence pathogenicity. Currently, a group of sigmoidal mathematical equations are used to empirically describe dose-response relations. While these have proven to be highly useful, advances in microbial food safety risk assessment will likely require the development of mechanistic models that more effectively consider the range of factors that influence the frequency and severity of foodborne infections in a population. JF - International journal of food microbiology AU - Buchanan, R L AU - Smith, J L AU - Long, W AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington DC 20204, USA. Y1 - 2000/07/15/ PY - 2000 DA - 2000 Jul 15 SP - 159 EP - 172 VL - 58 IS - 3 SN - 0168-1605, 0168-1605 KW - Immunologic Factors KW - 0 KW - Index Medicus KW - Virulence KW - Food Contamination -- prevention & control KW - Animals KW - Immunologic Factors -- physiology KW - Humans KW - Dose-Response Relationship, Immunologic KW - Safety KW - Food Contamination -- analysis KW - Food Microbiology KW - Risk Assessment -- statistics & numerical data KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71747899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Microbial+risk+assessment%3A+dose-response+relations+and+risk+characterization.&rft.au=Buchanan%2C+R+L%3BSmith%2C+J+L%3BLong%2C+W&rft.aulast=Buchanan&rft.aufirst=R&rft.date=2000-07-15&rft.volume=58&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-07 N1 - Date created - 2000-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Work related deaths in West Virginia. Targeting research and prevention efforts. AN - 72591978; 11261182 JF - AAOHN journal : official journal of the American Association of Occupational Health Nurses AU - Higgins, D N AU - Helmkamp, J C AU - Williams, J M AU - King, M E AD - Trauma Investigations Section, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 331 EP - 337 VL - 48 IS - 7 SN - 0891-0162, 0891-0162 KW - Nursing KW - Occupational Health KW - Information Services KW - Humans KW - Aged KW - Health Education KW - Population Surveillance -- methods KW - Cause of Death KW - Risk Factors KW - Adult KW - Death Certificates KW - Guidelines as Topic KW - Middle Aged KW - Occupational Health Nursing KW - Adolescent KW - West Virginia -- epidemiology KW - Female KW - Male KW - Research -- organization & administration KW - Accidents, Occupational -- prevention & control KW - Primary Prevention -- organization & administration KW - Needs Assessment -- organization & administration KW - Occupational Health Services -- organization & administration KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72591978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAOHN+journal+%3A+official+journal+of+the+American+Association+of+Occupational+Health+Nurses&rft.atitle=Work+related+deaths+in+West+Virginia.+Targeting+research+and+prevention+efforts.&rft.au=Higgins%2C+D+N%3BHelmkamp%2C+J+C%3BWilliams%2C+J+M%3BKing%2C+M+E&rft.aulast=Higgins&rft.aufirst=D&rft.date=2000-07-01&rft.volume=48&rft.issue=7&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=AAOHN+journal+%3A+official+journal+of+the+American+Association+of+Occupational+Health+Nurses&rft.issn=08910162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of vitamin K1 in medical foods by liquid chromatography with postcolumn reduction and fluorometric detection. AN - 72269165; 10995121 AB - A liquid chromatographic (LC) method is described for the determination of vitamin K1 in medical foods. The sample is enzymatically digested with lipase and alpha-amylase and extracted with 1% sodium bicarbonate solution-isopropanol (1 + 1). After C18 solid-phase extraction, vitamin K1 is separated by nonaqueous reversed-phase LC, converted to the hydroquinone by postcolumn zinc reduction, and quantitated by fluorescence detection. The limit of detection is 8 pg (3 sigma), and the limit of quantitation is 27 pg (10 sigma) on column. Linear response ranged from 0.1 to 1.0 ng vitamin K1 (r= 0.9999). The mean recovery (n = 38) for all spiking levels was 101.6 +/- 2.85%. Analysis of Standard Reference Material 1846, Infant Formula, gave a mean value of 0.95 +/- 0.088 mg vitamin K/kg (K or K1?) (n = 31) with a coefficient of variation of 9.26. JF - Journal of AOAC International AU - Ware, G M AU - Chase, G W AU - Eitenmiller, R R AU - Long, A R AD - US Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309, USA. PY - 2000 SP - 957 EP - 962 VL - 83 IS - 4 SN - 1060-3271, 1060-3271 KW - Buffers KW - 0 KW - Hydroquinones KW - Vitamin K 1 KW - 84-80-0 KW - Sodium Bicarbonate KW - 8MDF5V39QO KW - Lipase KW - EC 3.1.1.3 KW - alpha-Amylases KW - EC 3.2.1.1 KW - 2-Propanol KW - ND2M416302 KW - hydroquinone KW - XV74C1N1AE KW - Index Medicus KW - Sensitivity and Specificity KW - Hydrogen-Ion Concentration KW - Humans KW - alpha-Amylases -- metabolism KW - Quality Control KW - Lipase -- metabolism KW - Food, Formulated -- analysis KW - Chromatography, Liquid -- methods KW - Vitamin K 1 -- analysis KW - Fluorometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72269165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+vitamin+K1+in+medical+foods+by+liquid+chromatography+with+postcolumn+reduction+and+fluorometric+detection.&rft.au=Ware%2C+G+M%3BChase%2C+G+W%3BEitenmiller%2C+R+R%3BLong%2C+A+R&rft.aulast=Ware&rft.aufirst=G&rft.date=2000-07-01&rft.volume=83&rft.issue=4&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Warming up to safe infusions. AN - 72249853; 10983109 JF - Nursing AU - Morrison, A AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md., USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 78 VL - 30 IS - 7 SN - 0360-4039, 0360-4039 KW - Nursing KW - Aged, 80 and over KW - Humans KW - Safety KW - Aged KW - Blood Transfusion -- adverse effects KW - Embolism, Air -- etiology KW - Embolism, Air -- prevention & control KW - Hot Temperature -- adverse effects KW - Blood Transfusion -- nursing KW - Fluid Therapy -- adverse effects KW - Fluid Therapy -- nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72249853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Warming+up+to+safe+infusions.&rft.au=Morrison%2C+A&rft.aulast=Morrison&rft.aufirst=A&rft.date=2000-07-01&rft.volume=30&rft.issue=7&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=03604039&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-14 N1 - Date created - 2000-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal and offspring toxicity but few sexually dimorphic behavioral alterations result from nonylphenol exposure. AN - 72241032; 10974597 AB - Nonylphenol ethoxylates are used in the production of surfactants and are found in numerous manufactured substances. para-Nonylphenol (NP) is a suspected endocrine disruptor, exhibiting estrogen-like activity and might cause alterations with developmental exposure. To evaluate such effects, pregnant Sprague-Dawley rats consumed diets containing 0 (n = 11), 25 (n = 10), 500 (n = 10), or 2,000 (n = 9) ppm NP beginning on gestational day (GD) 7. At postnatal day (PND) 21, offspring continued on the same maternal diets until PND 77 and were evaluated for behavioral alterations (open-field activity at PNDs 22-24, 43-45, 64-66, play behavior at PND 35, running wheel activity at PND 63-77, flavored solution intake at PND 69-75). During pregnancy and lactation, dams in the 25-, 500-, and 2,000-ppm groups consumed 9 to 25% less food, which was associated with a 17% less weight gain during GDs 1 to 21 in dams of the 2,000-ppm group, although this effect was not statistically significant. Gestation duration, birth weight, sex ratio of live pups, and number of live or dead pups per litter did not differ between treatment groups. Offspring body weight and food consumption were decreased in the 2, 000-ppm group beginning at PND 28; however, an effect of feed aversion could not be eliminated. Behavioral assessments of offspring indicated no consistent NP-related effects in open-field activity at PNDs 22-24, 43-45, and 65-67 nor in running wheel activity at PNDs 63-75. Play behavior at PND 35 and intake of a 0.3% saccharin-flavored solution at PNDs 69-71 did not differ with respect to treatment groups. However, intake of a 3% sodium-flavored solution at PNDs 73-75 was significantly increased in offspring of the 2,000-ppm group and intake of regular water during this same time was also significantly increased. These results indicate that developmental NP treatment results in maternal and offspring toxicity as evidenced by decreased food intake and weight gain. However, behavioral alterations were evident only in increased intake of a sodium solution. JF - Neurotoxicology and teratology AU - Ferguson, S A AU - Flynn, K M AU - Delclos, K B AU - Newbold, R R AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. sferguson@nctr.fda.gov PY - 2000 SP - 583 EP - 591 VL - 22 IS - 4 SN - 0892-0362, 0892-0362 KW - Phenols KW - 0 KW - nonylphenol KW - 79F6A2ILP5 KW - Index Medicus KW - Rats KW - Eating -- drug effects KW - Drinking Behavior -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Male KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Behavior, Animal -- drug effects KW - Phenols -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72241032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Maternal+and+offspring+toxicity+but+few+sexually+dimorphic+behavioral+alterations+result+from+nonylphenol+exposure.&rft.au=Ferguson%2C+S+A%3BFlynn%2C+K+M%3BDelclos%2C+K+B%3BNewbold%2C+R+R&rft.aulast=Ferguson&rft.aufirst=S&rft.date=2000-07-01&rft.volume=22&rft.issue=4&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-02 N1 - Date created - 2000-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of various treatments on the quantitative recovery of endotoxin from water-soluble metalworking fluids. AN - 72239860; 10976681 AB - Three extraction methods were compared for their effectiveness in the quantitative removal of endotoxin from unused and used bulk water-soluble metalworking fluid (MWF) samples. Soluble, synthetic, and semisynthetic fluids were studied. The three modes of extraction consisted of (1) pyrogen-free water (PFW); (2) PFW and Tween 20 (polyoxyethylene sorbitan monolaurate); and (3) PFW, Tween 20, and sonication. Results suggest that vigorous recovery methods yield higher amounts of endotoxin from MWF samples than mild recovery methods in PFW alone. Additional studies are required to aid in the understanding of the factors that significantly affect endotoxin extraction yields from these fluids. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Brown, M E AU - White, E M AU - Feng, A AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. PY - 2000 SP - 517 EP - 520 VL - 61 IS - 4 SN - 1529-8663, 1529-8663 KW - Aerosols KW - 0 KW - Endotoxins KW - Index Medicus KW - Occupational Exposure -- prevention & control KW - Humans KW - Occupational Exposure -- analysis KW - Aerosols -- analysis KW - Limulus Test -- methods KW - Air Microbiology KW - Endotoxins -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72239860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Effects+of+various+treatments+on+the+quantitative+recovery+of+endotoxin+from+water-soluble+metalworking+fluids.&rft.au=Brown%2C+M+E%3BWhite%2C+E+M%3BFeng%2C+A&rft.aulast=Brown&rft.aufirst=M&rft.date=2000-07-01&rft.volume=61&rft.issue=4&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of workers' perceived sense of slip and effect of prior knowledge of slipperiness during task performance on slippery surfaces. AN - 72238245; 10976678 AB - Forty healthy industrial workers (age: 41.0+/-14.9 years) were tested for postural stability for three simulated tasks: (1) standing upright; (2) rapid trunk movement; and (3) lateral reach during lifting. These tasks were performed on four levels of slippery surfaces under different environmental lighting with new or workers' own old shoes. Prior to postural stability tests, each subject was given the opportunity to assess the surface slipperiness that he or she would encounter in the subsequent postural stability tests. A perceived sense of slip (PSOS) scale was administrated immediately after each test to determine subjects' PSOS. Subjects' postural sway and instability during task performance was determined by using a strain gauge type force platform. Results from this study indicate that subjects who were cautious in assessing surface slipperiness had less postural instability during task performance. Subjects could perceive the likely slips due to the change in task (p=0.0001) and surface slipperiness (p=0.0001). The PSOS scale is reproducible, easy to use, and provides a simple way to evaluate potential slip hazards in the workplace. Results from this study should aid understanding of the factors critical to maintaining postural stability on slippery surfaces, and will help to develop guidelines for safety training and identify slip hazards in the workplace. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Chiou, S AU - Bhattacharya, A AU - Succop, P A AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. PY - 2000 SP - 492 EP - 500 VL - 61 IS - 4 SN - 1529-8663, 1529-8663 KW - Index Medicus KW - Analysis of Variance KW - Reproducibility of Results KW - Humans KW - Adult KW - Lighting KW - Shoes KW - Middle Aged KW - Posture KW - Accidents, Occupational -- prevention & control KW - Floors and Floorcoverings KW - Safety Management -- methods KW - Task Performance and Analysis KW - Surface Properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72238245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Evaluation+of+workers%27+perceived+sense+of+slip+and+effect+of+prior+knowledge+of+slipperiness+during+task+performance+on+slippery+surfaces.&rft.au=Chiou%2C+S%3BBhattacharya%2C+A%3BSuccop%2C+P+A&rft.aulast=Chiou&rft.aufirst=S&rft.date=2000-07-01&rft.volume=61&rft.issue=4&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a versatile method for the detection of nicotine in air. AN - 72238026; 10976675 AB - Nicotine, a rapid-acting poison, is present in environmental tobacco smoke and has been used as a greenhouse insecticide. Due to its toxicity, several health hazard evaluations (HHE) have resulted from potential nicotine exposures to casino workers, airline flight attendants, and greenhouse employees. Exposure to nicotine can occur by inhalation, skin adsorption, and ingestion, resulting in such adverse health effects as nausea, vomiting, headache, dizziness, tachycardia, hypertension, convulsions, and cardiac arrhythmia. The development of an improved sampling and analytical methodology for nicotine was required to accommodate the broad concentration of nicotine levels and varying sampling scenarios presented by the differing HHE requests. A XAD-4 sorbent tube was selected for the collection of airborne nicotine. Analytical methodology for the separation, identification, and quantitation of nicotine by both gas chromatography-flame ionization detection and gas chromatography-nitrogen/ phosphorous detection is described. The limit of detection for nicotine was 0.013 microg/sample. The desorption efficiency for nicotine was determined over the range of study and ranged from 90.9% (0.096 microg) to 93.7% (24.0 microg). Nicotine exhibited storage stability for 30 days at 5 degrees C and for 14 days at ambient temperature. Based on the results of this research study, the new method for nicotine was published in the NIOSH Manual of Analytical Methods (NMAM 2551). JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Pendergrass, S M AU - Krake, A M AU - Jaycox, L B AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. PY - 2000 SP - 469 EP - 472 VL - 61 IS - 4 SN - 1529-8663, 1529-8663 KW - Air Pollutants KW - 0 KW - Pesticides KW - Tobacco Smoke Pollution KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Sensitivity and Specificity KW - Flame Ionization KW - Reproducibility of Results KW - Humans KW - Calibration KW - Drug Storage KW - Nicotine -- analysis KW - Tobacco Smoke Pollution -- analysis KW - Air Pollutants -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72238026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Development+of+a+versatile+method+for+the+detection+of+nicotine+in+air.&rft.au=Pendergrass%2C+S+M%3BKrake%2C+A+M%3BJaycox%2C+L+B&rft.aulast=Pendergrass&rft.aufirst=S&rft.date=2000-07-01&rft.volume=61&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: AIHAJ. 2001 Nov-Dec;62(6):665-7 [11767927] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CpG ODN-mediated regulation of IL-12 p40 transcription. AN - 71742400; 10940886 AB - Oligodeoxynucleotides (ODN) containing CpG motifs activate RAW 264.7 mouse macrophages and RPMI 8226 human myeloma cells to produce IL-12 p40. Using deletion and site-directed mutagenesis, the nuclear factor (NF)-kappaB half-site and the CCAAT/enhancer binding protein (C/EBP) recognition site were identified as potent cis-acting elements in CpG ODN-mediated IL-12 p40 promoter activation. Several NF-kappaB/Rel proteins competed for binding to the NF-kappaB half-site. The p65/c-Rel and p65/p50 heterodimer occupied this site shortly after CpG ODN administration (0.5-2 h), while the p50/c-Rel heterodimer dominated binding in the late stage (8-12 h). The induction of p50/c-Rel heterodimer was associated with a significant expression of IL-12 p40 mRNA. C/EBPbeta also contributed to CpG ODN-mediated IL-12 p40 promoter activation. JF - European journal of immunology AU - Takeshita, F AU - Klinman, D M AD - Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda 20892, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 1967 EP - 1976 VL - 30 IS - 7 SN - 0014-2980, 0014-2980 KW - Adjuvants, Immunologic KW - 0 KW - CCAAT-Enhancer-Binding Proteins KW - CPG-oligonucleotide KW - DNA-Binding Proteins KW - NF-kappa B KW - NF-kappa B p50 Subunit KW - Nuclear Proteins KW - Oligodeoxyribonucleotides KW - Oligonucleotides KW - Proto-Oncogene Proteins c-rel KW - Thionucleotides KW - Transcription Factor RelA KW - Interleukin-12 KW - 187348-17-0 KW - Index Medicus KW - Macrophages -- cytology KW - Proto-Oncogene Proteins c-rel -- metabolism KW - Animals KW - Transcription, Genetic -- drug effects KW - Proto-Oncogene Proteins c-rel -- genetics KW - Nuclear Proteins -- genetics KW - Macrophages -- immunology KW - Dimerization KW - Humans KW - DNA-Binding Proteins -- genetics KW - Mice KW - Macrophages -- drug effects KW - NF-kappa B -- genetics KW - Binding Sites KW - Promoter Regions, Genetic KW - Tumor Cells, Cultured KW - Nuclear Proteins -- metabolism KW - Cell Line KW - NF-kappa B -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Thionucleotides -- pharmacology KW - Oligonucleotides -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Adjuvants, Immunologic -- pharmacology KW - Interleukin-12 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71742400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=CpG+ODN-mediated+regulation+of+IL-12+p40+transcription.&rft.au=Takeshita%2C+F%3BKlinman%2C+D+M&rft.aulast=Takeshita&rft.aufirst=F&rft.date=2000-07-01&rft.volume=30&rft.issue=7&rft.spage=1967&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-13 N1 - Date created - 2000-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prioritization of NTP reproductive toxicants for field studies. AN - 71256505; 10908832 AB - Population studies that evaluate human reproductive impairment are time consuming, expensive, logistically difficult, and with limited resources must be prioritized to effectively prevent the adverse health effects in humans. Interactions among health scientists, unions, and industry can serve to identify populations exposed to potential hazards and develop strategies to evaluate and apply appropriate controls. This report describes a systematic method for prioritizing chemicals that may need human reproductive health field studies. Rodent reproductive toxicants identified from the National Toxicology Program (NTP) Reproductive Assessment by Continuous Breeding (RACB) protocol were prioritized on the basis of potency of toxic effect and population at risk. This model for prioritization links NTP findings with data from the National Occupational Exposure Survey (NOES) and the Hazardous Substance Data Base (HSDB) or the High Production Volume Chemical Database (HPVC) to prioritize chemicals for their potential impact on worker populations. The chemicals with the highest priority for field study were: dibutyl phthalate, boric acid, tricresyl phosphate, and N, N-dimethylformamide. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Moorman, W J AU - Ahlers, H W AU - Chapin, R E AU - Daston, G P AU - Foster, P M AU - Kavlock, R J AU - Morawetz, J S AU - Schnorr, T M AU - Schrader, S M AD - National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Pkwy, Cincinnati OH 45226, USA. wjm2@cdc.gov PY - 2000 SP - 293 EP - 301 VL - 14 IS - 4 SN - 0890-6238, 0890-6238 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Animals KW - No-Observed-Adverse-Effect Level KW - Maximum Allowable Concentration KW - Humans KW - Toxicity Tests KW - Consensus Development Conferences as Topic KW - Mice KW - Male KW - Female KW - Risk Assessment KW - Occupational Exposure -- prevention & control KW - Hazardous Substances -- adverse effects KW - Reproduction -- drug effects KW - Health Priorities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71256505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Prioritization+of+NTP+reproductive+toxicants+for+field+studies.&rft.au=Moorman%2C+W+J%3BAhlers%2C+H+W%3BChapin%2C+R+E%3BDaston%2C+G+P%3BFoster%2C+P+M%3BKavlock%2C+R+J%3BMorawetz%2C+J+S%3BSchnorr%2C+T+M%3BSchrader%2C+S+M&rft.aulast=Moorman&rft.aufirst=W&rft.date=2000-07-01&rft.volume=14&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-07 N1 - Date created - 2000-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improved rapid analytical method for the urinary determination of 3, 5,6 trichloro-2-pyridinol, a metabolite of chlorpyrifos. AN - 71255443; 10874072 JF - Bulletin of environmental contamination and toxicology AU - MacKenzie, B A AU - Striley, C A AU - Biagini, R E AU - Stettler, L E AU - Hines, C J AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 1 EP - 7 VL - 65 IS - 1 SN - 0007-4861, 0007-4861 KW - Herbicides KW - 0 KW - Insecticides KW - Pyridones KW - 3,5,6-trichloro-2-pyridinol KW - 6515-38-4 KW - Chlorpyrifos KW - JCS58I644W KW - Index Medicus KW - Sensitivity and Specificity KW - Insecticides -- metabolism KW - Agriculture KW - Immunoassay -- methods KW - Humans KW - Chlorpyrifos -- analogs & derivatives KW - Insecticides -- urine KW - Chlorpyrifos -- urine KW - Chlorpyrifos -- metabolism KW - Pyridones -- urine KW - Occupational Exposure KW - Herbicides -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71255443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+environmental+contamination+and+toxicology&rft.atitle=Improved+rapid+analytical+method+for+the+urinary+determination+of+3%2C+5%2C6+trichloro-2-pyridinol%2C+a+metabolite+of+chlorpyrifos.&rft.au=MacKenzie%2C+B+A%3BStriley%2C+C+A%3BBiagini%2C+R+E%3BStettler%2C+L+E%3BHines%2C+C+J&rft.aulast=MacKenzie&rft.aufirst=B&rft.date=2000-07-01&rft.volume=65&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+environmental+contamination+and+toxicology&rft.issn=00074861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-08 N1 - Date created - 2000-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolation of Salmonella spp. from the housefly, Musca domestica L., and the dump fly, Hydrotaea aenescens (Wiedemann) (Diptera: Muscidae), at caged-layer houses. AN - 71254081; 10914668 AB - Flies, especially houseflies, are widely recognized as potential reservoirs and vectors of foodborne Salmonella pathogens. In this study, flies were collected at caged-layer facilities that had produced eggs that were implicated as the food vehicle in two recent outbreaks of Salmonella Enteritidis infections. The flies were separated by species into pools for microbiological testing. A total of 15 species pools of houseflies, Musca domestica L., and 7 species pools of bronze dump flies, Hydrotaea aenescens (Wiedemann) (Diptera: Muscidae), were analyzed. Salmonella Enteritidis was isolated from 2 of the 15 pools of houseflies. Other species of Salmonella were isolated from three pools of flies, including Salmonella Infantis from houseflies and from dump flies and Salmonella Heidelberg from houseflies. Salmonella Mbandaka was isolated from a lesser mealworm, Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae). JF - Journal of food protection AU - Olsen, A R AU - Hammack, T S AD - U.S. Food and Drug Administration, Washington, DC 20204, USA. aolsen@bangate.fda.gov Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 958 EP - 960 VL - 63 IS - 7 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Animals KW - Chickens KW - Beetles -- microbiology KW - Salmonella enteritidis -- growth & development KW - Humans KW - Chick Embryo KW - Housing, Animal KW - Disease Reservoirs KW - Male KW - Female KW - Salmonella enteritidis -- isolation & purification KW - Insect Control KW - Food Microbiology KW - Eggs -- microbiology KW - Salmonella -- growth & development KW - Muscidae -- microbiology KW - Salmonella Infections -- prevention & control KW - Insect Vectors -- microbiology KW - Salmonella -- isolation & purification KW - Salmonella Infections -- microbiology KW - Houseflies -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71254081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Isolation+of+Salmonella+spp.+from+the+housefly%2C+Musca+domestica+L.%2C+and+the+dump+fly%2C+Hydrotaea+aenescens+%28Wiedemann%29+%28Diptera%3A+Muscidae%29%2C+at+caged-layer+houses.&rft.au=Olsen%2C+A+R%3BHammack%2C+T+S&rft.aulast=Olsen&rft.aufirst=A&rft.date=2000-07-01&rft.volume=63&rft.issue=7&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-21 N1 - Date created - 2000-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dietary considerations to prevent loss of bone and renal function. AN - 71243513; 10906557 JF - Nutrition (Burbank, Los Angeles County, Calif.) AU - Calvo, M S AD - Clinical Research and Review Staff, Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. mona.calvo@cfsan.fda.gov PY - 2000 SP - 564 EP - 566 VL - 16 IS - 7-8 SN - 0899-9007, 0899-9007 KW - Calcium, Dietary KW - 0 KW - Parathyroid Hormone KW - Phosphorus, Dietary KW - Vitamin D KW - 1406-16-2 KW - Index Medicus KW - Animals KW - Milk KW - Calcium, Dietary -- pharmacokinetics KW - Parathyroid Hormone -- physiology KW - Humans KW - Calcium, Dietary -- administration & dosage KW - Vitamin D -- administration & dosage KW - Phosphorus, Dietary -- adverse effects KW - Phosphorus, Dietary -- administration & dosage KW - Phosphorus, Dietary -- pharmacokinetics KW - Carbonated Beverages KW - Osteoporosis -- prevention & control KW - Kidney Diseases -- prevention & control KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71243513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.atitle=Dietary+considerations+to+prevent+loss+of+bone+and+renal+function.&rft.au=Calvo%2C+M+S&rft.aulast=Calvo&rft.aufirst=M&rft.date=2000-07-01&rft.volume=16&rft.issue=7-8&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.issn=08999007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-24 N1 - Date created - 2000-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin. AN - 71240962; 10873714 AB - 2-Nitro-p-phenylenediamine (2NPPD) is a dye used in semipermanent and permanent (tinting color) hair dye formulations. National Toxicology Program toxicology and carcinogenesis testing of 2NPPD has raised concerns about its safety. Therefore, we initiated in vitro studies to measure absorption and metabolism of 2NPPD in human and fuzzy rat skin and rat jejunal tissue. Intestinal tissue metabolism of 2NPPD was compared to skin metabolism since toxicology data from oral 2NPPD studies will be used for future safety assessment purposes. Absorption was measured over 24 h by using flow-through diffusion cells with a receptor fluid consisting of Hepes-buffered Hank's balanced salt solution. Dosing vehicles were applied to skin and intestine in the diffusion cells for 30 min. 2NPPD metabolites were determined by high-performance liquid chromatography methodology. In human skin, the percentages of total applied dose absorbed (receptor fluid + skin) over 24 h were 9.2 +/- 5.7 (mean +/- SD) and 9.5 +/- 3.2 for the ethanol and semipermanent vehicles, respectively, with approximately 3% remaining in skin. In rat skin, the percentages of total applied dose absorbed over 24 h were 9.3 +/- 1.2 (mean +/- SE), 6.9 +/- 1.2, and 4.2 +/- 0.1 for the ethanol, semipermanent, and permanent formulation vehicles, respectively, with approximately 3% remaining in skin. In rat intestinal tissue, the percentage of total applied dose absorbed over 24 h was 10.9 +/- 1.2, with approximately 5% remaining in the tissue. In human and rat skin, 2NPPD was metabolized to triaminobenzene and N4-acetyl-2NPPD. 2NPPD was also metabolized to a sulfated 2NPPD metabolite in rat skin, but not in human skin. 2NPPD was extensively metabolized in both human and rat skin with ethanol application; metabolism was not as extensive with a semipermanent formulation application. In rat intestinal tissue, 62% of 2NPPD was metabolized upon absorption to triaminobenzene and N4-acetyl-2NPPD. Differences in the metabolic profiles (proportion of each metabolite formed) were found between the skin and intestinal tissue. These results suggest that 2NPPD is rapidly absorbed and extensively metabolized in both skin and intestinal tissue. The extent of metabolism and the metabolic profile were found to be species-, tissue-, and dosing vehicle-dependent. Metabolism information will be useful in predicting the extent of 2NPPD and/or 2NPPD metabolite systemic absorption relative to a dermal exposure, which will improve the health hazard assessment of 2NPPD. JF - Toxicology and applied pharmacology AU - Yourick, J J AU - Bronaugh, R L AD - Skin Absorption and Metabolism Section, Cosmetics Toxicology Branch, U.S. Food and Drug Administration, Laurel, MD 20708, USA. JJY@CFSAN.FDA.GOV Y1 - 2000/07/01/ PY - 2000 DA - 2000 Jul 01 SP - 13 EP - 23 VL - 166 IS - 1 SN - 0041-008X, 0041-008X KW - Carcinogens KW - 0 KW - Phenylenediamines KW - 2-nitro-4-phenylenediamine KW - PV83F3C01Q KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Administration, Cutaneous KW - Humans KW - Intestinal Absorption KW - Female KW - Skin -- drug effects KW - Phenylenediamines -- toxicity KW - Skin -- metabolism KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- toxicity KW - Phenylenediamines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71240962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Percutaneous+penetration+and+metabolism+of+2-nitro-p-phenylenediamine+in+human+and+fuzzy+rat+skin.&rft.au=Yourick%2C+J+J%3BBronaugh%2C+R+L&rft.aulast=Yourick&rft.aufirst=J&rft.date=2000-07-01&rft.volume=166&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-15 N1 - Date created - 2000-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Retinoids in embryonal development. AN - 71236898; 10893430 AB - The key role of vitamin A in embryonal development is reviewed. Special emphasis is given to the physiological action of retinoids, as evident from the retinoid ligand knockout models. Retinoid metabolism in embryonic tissues and teratogenic consequences of retinoid administration at high doses are presented. Physiological and pharmacological actions of retinoids are outlined and explained on the basis of their interactions as ligands of the nuclear retinoid receptors. Immediate target genes and the retinoid response elements of their promoters are summarized. The fundamental role of homeobox genes in embryonal development and the actions of retinoids on their expression are discussed. The similarity of the effects of retinoid ligand knockouts to effects of compound retinoid receptor knockouts on embryogenesis is presented. Although much remains to be clarified, the emerging landscape offers exciting views for future research. JF - Physiological reviews AU - Ross, S A AU - McCaffery, P J AU - Drager, U C AU - De Luca, L M AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements, Washington, DC, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 1021 EP - 1054 VL - 80 IS - 3 SN - 0031-9333, 0031-9333 KW - Receptors, Retinoic Acid KW - 0 KW - Retinoids KW - Teratogens KW - Index Medicus KW - Teratogens -- metabolism KW - Animals KW - Humans KW - Mice KW - Mice, Knockout KW - Genes, Homeobox -- physiology KW - Receptors, Retinoic Acid -- physiology KW - Retinoids -- metabolism KW - Retinoids -- chemistry KW - Embryonic and Fetal Development -- physiology KW - Abnormalities, Drug-Induced -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71236898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+reviews&rft.atitle=Retinoids+in+embryonal+development.&rft.au=Ross%2C+S+A%3BMcCaffery%2C+P+J%3BDrager%2C+U+C%3BDe+Luca%2C+L+M&rft.aulast=Ross&rft.aufirst=S&rft.date=2000-07-01&rft.volume=80&rft.issue=3&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Physiological+reviews&rft.issn=00319333&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-16 N1 - Date created - 2000-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. AN - 71235058; 10910055 AB - Although the mechanism of action has not yet been defined, epidemiological studies have demonstrated an association between elevated arsenic levels in drinking water and the incidence of urinary bladder transitional cell carcinomas. In the current studies, we demonstrate that mice exposed to 0.01% sodium arsenite in drinking water develop hyperplasia of the bladder urothelium within 4 weeks of exposure. This was accompanied by the accumulation of inorganic trivalent arsenic, and to a lesser extent dimethylarsinic acid, in bladder tissue, as well as a persistent increase in DNA binding of the activating protein (AP)-1 transcription factor. AP-1 transactivation by arsenic also occurred in bladders of transgenic mice containing an AP-1 luciferase reporter. Consistent with these in vivo observations, arsenite increased cell proliferation and AP-1 DNA binding in a human bladder epithelial cell line. Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45. The proliferation-enhancing effect of arsenic on uroepithelial cells likely contributes to its ability to cause cancer. JF - Cancer research AU - Simeonova, P P AU - Wang, S AU - Toriuma, W AU - Kommineni, V AU - Matheson, J AU - Unimye, N AU - Kayama, F AU - Harki, D AU - Ding, M AU - Vallyathan, V AU - Luster, M I AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, NIH, Morgantown, West Virginia 26505, USA. phs9@cdc.gov Y1 - 2000/07/01/ PY - 2000 DA - 2000 Jul 01 SP - 3445 EP - 3453 VL - 60 IS - 13 SN - 0008-5472, 0008-5472 KW - Arsenates KW - 0 KW - Arsenites KW - CCAAT-Enhancer-Binding Proteins KW - DDIT3 protein, human KW - DNA-Binding Proteins KW - Ddit3 protein, mouse KW - EGR1 protein, human KW - Early Growth Response Protein 1 KW - Egr1 protein, mouse KW - GADD45 protein KW - Immediate-Early Proteins KW - Intracellular Signaling Peptides and Proteins KW - Proteins KW - Sodium Compounds KW - Transcription Factor AP-1 KW - Transcription Factors KW - Transcription Factor CHOP KW - 147336-12-7 KW - sodium arsenite KW - 48OVY2OC72 KW - Luciferases KW - EC 1.13.12.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Tetradecanoylphorbol Acetate -- toxicity KW - Animals KW - Arsenates -- pharmacokinetics KW - DNA Damage KW - Humans KW - Cell Division -- drug effects KW - DNA-Binding Proteins -- genetics KW - Mice KW - Tissue Distribution KW - Mice, Transgenic KW - Transcription Factors -- genetics KW - Proteins -- genetics KW - Transcriptional Activation KW - Mice, Inbred DBA KW - Hyperplasia KW - Mice, Inbred C57BL KW - Crosses, Genetic KW - Genes, fos KW - Luciferases -- genetics KW - Male KW - Female KW - Genes, jun KW - Urinary Bladder -- pathology KW - Urinary Bladder -- metabolism KW - Urothelium -- drug effects KW - Urothelium -- pathology KW - Transcription Factor AP-1 -- metabolism KW - Urothelium -- metabolism KW - Arsenites -- toxicity KW - Sodium Compounds -- toxicity KW - Gene Expression Regulation -- drug effects KW - Sodium Compounds -- pharmacokinetics KW - Transcription Factor AP-1 -- genetics KW - Arsenites -- pharmacokinetics KW - Urinary Bladder -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71235058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Arsenic+mediates+cell+proliferation+and+gene+expression+in+the+bladder+epithelium%3A+association+with+activating+protein-1+transactivation.&rft.au=Simeonova%2C+P+P%3BWang%2C+S%3BToriuma%2C+W%3BKommineni%2C+V%3BMatheson%2C+J%3BUnimye%2C+N%3BKayama%2C+F%3BHarki%2C+D%3BDing%2C+M%3BVallyathan%2C+V%3BLuster%2C+M+I&rft.aulast=Simeonova&rft.aufirst=P&rft.date=2000-07-01&rft.volume=60&rft.issue=13&rft.spage=3445&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-17 N1 - Date created - 2000-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene. AN - 71231292; 10874023 AB - Coal tar is a complex mixture containing hundreds of compounds, at least 30 of which are polycyclic aromatic hydrocarbons, including the carcinogen benzo[a]pyrene (BaP). Although humans are exposed to complex mixtures on a daily basis, the synergistic or individual effects of components within a mixture on the carcinogenic process remain unclear. We have compared DNA adduct formation and cell proliferation in mice fed coal tar or BaP for 4 weeks with tumor formation in a 2 year chronic feeding study. Additionally, we have analyzed tumor DNA for mutations in the K-ras, H-ras and p53 genes. In the forestomach of mice fed either coal tar or BaP an adduct indicative of BaP was detected, with adduct levels increasing in a dose-responsive manner. K-ras mutations were detected in the forestomach tumors, with the incidence being similar in mice fed coal tar or BaP. These results suggest that the BaP within coal tar is associated with forestomach tumor induction in coal tar-fed mice. DNA adduct levels in the small intestine were not predictive of tumor incidence in this tissue; instead, the tumors appeared to result from compound-induced cell proliferation at high doses of coal tar. K-ras mutations were detected in lung tumors. Since lung tumors were not increased by BaP, coal tar components other than BaP appear to be responsible for the tumors induced in this tissue. H-ras mutations, primarily occurring at codon 61, were the most common mutation observed in liver tumors induced by coal tar. Since this mutation profile is observed in spontaneous hepatic tumors, components in the coal tar may be promoting the expansion of pre-existing lesions. JF - Carcinogenesis AU - Culp, S J AU - Warbritton, A R AU - Smith, B A AU - Li, E E AU - Beland, F A AD - National Center for Toxicological Research, Jefferson, AR 72079 and Pathology Associates International, Jefferson, AR 72079, USA. sculp@nctr.fda.gov Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 1433 EP - 1440 VL - 21 IS - 7 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - DNA Adducts KW - DNA, Neoplasm KW - Benzo(a)pyrene KW - 3417WMA06D KW - Coal Tar KW - 8007-45-2 KW - Index Medicus KW - Animals KW - Genes, p53 -- drug effects KW - Genes, ras -- drug effects KW - DNA Mutational Analysis KW - Intestine, Small -- cytology KW - Intestine, Small -- metabolism KW - Cell Division -- drug effects KW - Liver -- metabolism KW - Mice KW - Lung -- metabolism KW - Stomach -- drug effects KW - DNA, Neoplasm -- drug effects KW - Stomach -- cytology KW - Stomach -- metabolism KW - Genes, ras -- genetics KW - Liver -- drug effects KW - Genes, p53 -- genetics KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Lung -- drug effects KW - Intestine, Small -- drug effects KW - DNA, Neoplasm -- genetics KW - DNA, Neoplasm -- metabolism KW - Female KW - DNA Adducts -- biosynthesis KW - Coal Tar -- toxicity KW - Carcinogens -- metabolism KW - Neoplasms, Experimental -- chemically induced KW - Neoplasms, Experimental -- genetics KW - Coal Tar -- metabolism KW - Benzo(a)pyrene -- toxicity KW - Carcinogens -- toxicity KW - Neoplasms, Experimental -- metabolism KW - Neoplasms, Experimental -- pathology KW - Mutation KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71231292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=DNA+adduct+measurements%2C+cell+proliferation+and+tumor+mutation+induction+in+relation+to+tumor+formation+in+B6C3F1+mice+fed+coal+tar+or+benzo%5Ba%5Dpyrene.&rft.au=Culp%2C+S+J%3BWarbritton%2C+A+R%3BSmith%2C+B+A%3BLi%2C+E+E%3BBeland%2C+F+A&rft.aulast=Culp&rft.aufirst=S&rft.date=2000-07-01&rft.volume=21&rft.issue=7&rft.spage=1433&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-17 N1 - Date created - 2000-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Particulate penetration of porous foam used as a low flow rate respirable dust size classifier. AN - 71227929; 10893792 AB - Porous foam has been used as a material for classification of particulate matter into various size fractions. The penetration characteristics of a nominal 90 pores per inch porous foam were studied at various flow rates, face velocities, and foam plug diameters and compared to the aerosol penetration of a 10 mm Dorr Oliver cyclone operated at 1.7 L/min. Poly-dispersed triethanolamine spheres were classified through porous foam plugs and the resulting penetration was determined using an aerodynamic particle sizer. Results showed that for a given plug diameter, as face velocity increased from 26 to 39 cm/sec, the 50 percent cut point decreased from 4.5 to 3.8 microns. Furthermore, as the diameter of the plug increased from 4 to 12 mm, the 50 percent cut points were similar to other plug diameters at equivalent face velocities. The best match to the 1.7 L/min cyclone penetration characteristics occurred at a flow rate of 250 ml/min through a 25 mm by 4 mm diameter section of 90 pore per inch foam. Because of the need to provide short-term or real-time estimates of worker respirable dust exposure, porous foam may be a viable classification media for a low flow rate, disposable respirable dust sampler for use in the coal mining industry. JF - Applied occupational and environmental hygiene AU - Page, S J AU - Volkwein, J C AU - Baron, P A AU - Deye, G J AD - Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 561 EP - 568 VL - 15 IS - 7 SN - 1047-322X, 1047-322X KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Coal KW - Dust KW - Index Medicus KW - Particle Size KW - Inhalation Exposure KW - Humans KW - Porosity KW - Mining KW - Air Pollutants, Occupational -- classification KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71227929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Particulate+penetration+of+porous+foam+used+as+a+low+flow+rate+respirable+dust+size+classifier.&rft.au=Page%2C+S+J%3BVolkwein%2C+J+C%3BBaron%2C+P+A%3BDeye%2C+G+J&rft.aulast=Page&rft.aufirst=S&rft.date=2000-07-01&rft.volume=15&rft.issue=7&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-02 N1 - Date created - 2000-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis. AN - 71227469; 10891466 AB - Many antineoplastic drugs kill tumor cells by inducing apoptosis. This highly controlled mechanism of cell death is thought to be physiologically advantageous because apoptotic cells are removed by phagocytosis before they lose their permeability barrier, thus preventing induction of an inflammatory response to the dying cells. In contrast, necrotic cells lyse and release their contents into the extracellular space, thus inducing inflammation. In this report, we examine the effects of oxidative stress on chemotherapy-induced cell killing. We find that H(2)O(2) inhibits the ability of 4 different chemotherapy drugs (VP-16, doxorubicin, cisplatin, and AraC) to induce apoptosis in human Burkitt lymphoma cells. H(2)O(2) shifts the form of cell death from apoptosis to pyknosis/necrosis, which occurs after a significant delay compared with chemotherapy-induced apoptosis. It can also lower the degree of cell killing by these drugs. These effects of H(2)O(2) can be prevented by the antioxidant agents Desferal, Tempol, and dimethylsulfoxide. Phagocytosis by monocyte-derived macrophages of VP-16-treated lymphoma cells is also inhibited by H(2)O(2). Cells killed with H(2)O(2) (with or without VP-16) do ultimately undergo phagocytosis, but this occurs only after they have lost their permeability barrier. Thus, membrane-intact apoptotic cells are recognized and phagocytosed by monocyte-derived macrophages, but membrane-intact pyknotic/necrotic cells are not. The results suggest that chemotherapy-induced apoptosis and phagocytosis of cancer cells may be enhanced by including certain antioxidant agents in the treatment protocol. JF - Blood AU - Shacter, E AU - Williams, J A AU - Hinson, R M AU - Sentürker, S AU - Lee, Y J AD - Laboratory of Immunology, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. shacter@cber.fda.gov Y1 - 2000/07/01/ PY - 2000 DA - 2000 Jul 01 SP - 307 EP - 313 VL - 96 IS - 1 SN - 0006-4971, 0006-4971 KW - Antineoplastic Agents KW - 0 KW - Cytarabine KW - 04079A1RDZ KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Hydrogen Peroxide KW - BBX060AN9V KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Cell Nucleus -- pathology KW - Tumor Cells, Cultured KW - Kinetics KW - Humans KW - Cisplatin -- toxicity KW - Cytarabine -- toxicity KW - Doxorubicin -- toxicity KW - Cell Nucleus -- drug effects KW - Cell Membrane Permeability KW - Etoposide -- toxicity KW - Burkitt Lymphoma -- pathology KW - Hydrogen Peroxide -- toxicity KW - Apoptosis -- drug effects KW - Oxidative Stress -- drug effects KW - Antineoplastic Agents -- toxicity KW - Phagocytosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71227469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Oxidative+stress+interferes+with+cancer+chemotherapy%3A+inhibition+of+lymphoma+cell+apoptosis+and+phagocytosis.&rft.au=Shacter%2C+E%3BWilliams%2C+J+A%3BHinson%2C+R+M%3BSent%C3%BCrker%2C+S%3BLee%2C+Y+J&rft.aulast=Shacter&rft.aufirst=E&rft.date=2000-07-01&rft.volume=96&rft.issue=1&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-10 N1 - Date created - 2000-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using water sprays to improve performance of a flooded-bed dust scrubber. AN - 71225284; 10893791 AB - Supplemental water sprays were placed along the sides of a continuous mining machine to improve suppression and confinement of the dust cloud under the cutting boom to reduce downwind dust levels. Using a full-scale mock-up of a continuous mining machine, preliminary work showed that these side sprays improved suppression of the dust cloud and redistributed this cloud under the cutting head. This led to reductions in dust levels around the machine and in down-wind airways for some positions of the mining machine. This testing also showed that side spray effectiveness was influenced by the distance from the fresh air ventilation device to the cutting surface, termed the ventilation setback distance. These sprays produced larger reductions in machine and return dust levels at smaller setback distances than at larger setback distances. These side sprays then were installed in similar locations on a mining machine at an underground coal mine operation to evaluate their effectiveness for improving suppression and capture of dust by the flooded-bed dust scrubber. Although sampling could not be conducted successfully in the return, sampling around the mining machine and at the machine operator showed that dust levels decreased with use of these sprays. Further analysis showed that these sprays were most effective at the smaller setback distances, a result confirmed by full-scale laboratory testing. JF - Applied occupational and environmental hygiene AU - Goodman, G V AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pennsylvania, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 550 EP - 560 VL - 15 IS - 7 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Coal KW - Dust KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Ventilation KW - Humans KW - Occupational Health KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71225284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Using+water+sprays+to+improve+performance+of+a+flooded-bed+dust+scrubber.&rft.au=Goodman%2C+G+V&rft.aulast=Goodman&rft.aufirst=G&rft.date=2000-07-01&rft.volume=15&rft.issue=7&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-02 N1 - Date created - 2000-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Appl Occup Environ Hyg. 2001 Apr;16(4):439-40 [11318386] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Manganese dioxide exposures and respirator performance at an alkaline battery plant. AN - 71224202; 10893790 AB - Two industrial hygiene studies were conducted at an alkaline battery plant to evaluate worker exposures to manganese dioxide particulate and the effectiveness of filtering facepiece respirators. The work areas studied included the plant's powder-processing tower and press rooms where manganese was blended, compacted with graphite, and inserted into battery cans. Full-shift personal breathing zone monitoring was conducted to estimate manganese dust exposures of press operators, mechanics, and material handlers. In-facepiece and personal breathing zone air sampling pairs were also collected using a program protection factor protocol to estimate the protection provided by the respirators. Particle size evaluations were made using nylon cyclones and Marple personal multi-stage impactors. All samples were analyzed for manganese by inductively coupled argon plasma, atomic emission spectroscopy via NIOSH analytical method 7300 utilizing a modified acid digestion procedure. Fifty-four, full-shift, time-weighted average (TWA) exposures to total manganese ranged from 0.1 to 5.4 milligrams per cubic meter (mg/m3); worker exposures were substantially lower during a follow-up study due to engineering control improvements. Concurrent area sample comparisons of total and respirable manganese revealed that the respirable particulate mass fractions ranged from 6 to 32 percent, and mass median aerodynamic diameters determined from personal breathing zone air samples were mostly greater than 10 micrometers. Fifteen respirator performance evaluations were conducted using Moldex 2200 respirators fitted with 25 millimeter cassettes and light weight sampling probes. Protection factors ranged from 5 to 220, with a geometric mean and standard deviation of 31 and 2.97, respectively. The 5th percentile protection factor estimate was 5, as calculated from the protection factor distribution for this sample set. In 1995, the American Conference of Governmental Industrial Hygienists (ACGIH) lowered the elemental and inorganic manganese dust Threshold Limit Value (TLV) from 5 mg/m3 to 0.2 mg/m3 to address adverse pulmonary and central nervous system effects and male infertility. Although most personal breathing zone concentrations were above 0.2 mg/m3, none of the in-facepiece concentrations exceeded this concentration. Parkinson's-like symptoms have been reported in the literature for high manganese dust and fume exposures, but the importance of low dust exposures for producing neurological effects is uncertain. JF - Applied occupational and environmental hygiene AU - Hanley, K W AU - Lenhart, S W AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 542 EP - 549 VL - 15 IS - 7 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Manganese Compounds KW - Oxides KW - manganese dioxide KW - TF219GU161 KW - Index Medicus KW - Reference Values KW - Equipment Design KW - Particle Size KW - Inhalation Exposure KW - Humans KW - Adult KW - Male KW - Industry KW - Occupational Exposure KW - Oxides -- analysis KW - Air Pollutants, Occupational -- analysis KW - Respiratory Protective Devices -- standards KW - Manganese Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71224202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Manganese+dioxide+exposures+and+respirator+performance+at+an+alkaline+battery+plant.&rft.au=Hanley%2C+K+W%3BLenhart%2C+S+W&rft.aulast=Hanley&rft.aufirst=K&rft.date=2000-07-01&rft.volume=15&rft.issue=7&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-02 N1 - Date created - 2000-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro bioactivation of N-hydroxy-2-amino-alpha-carboline. AN - 71218081; 10874013 AB - 2-Amino-alpha-carboline (A alpha C) is a mutagenic and carcinogenic heterocyclic amine present in foods cooked at high temperature and in cigarette smoke. The mutagenic activity of A alpha C is dependent upon metabolic activation to N-hydroxy-A alpha C (N-OH-A alpha C); however, the metabolism of N-OH-A alpha C has not been studied. We have synthesized 2-nitro-alpha-carboline and N-OH-A alpha C and have examined in vitro bioactivation of N-OH-A alpha C by human and rodent liver cytosolic sulfotransferase(s) and acetyltransferase(s) and by recombinant human N-acetyltransferases, NAT1 and NAT2. The sulfotransferase-dependent bioactivation of N-OH-A alpha C by human liver cytosol exhibited large inter-individual variation (0.5-75, n = 14) and was significantly higher than bioactivation of N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP). Correlation and inhibition studies suggested that the isoform of sulfotransferase primarily responsible for bioactivation of N-OH-A alpha C in human liver cytosol is SULT1A1. O-Acetyltransferase-dependent bioactivation of N-OH-A alpha C by human liver cytosol also exhibited large inter-individual variation (16-192, n = 18). In contrast to other N-hydroxy heterocyclic amines, which are primarily substrates only for NAT2, both NAT1 and NAT2 catalyzed bioactivation of N-OH-A alpha C. The rate of bioactivation of N-OH-A alpha C by both NAT1 and NAT2 was significantly higher than that for N-OH-PhIP. In rat and mouse liver cytosols, the level of sulfotransferase-dependent bioactivation of N-OH-A alpha C was similar to the level in the high sulfotransferase activity human liver cytosol. The level of O-acetyltransferase-dependent bioactivation of N-OH-A alpha C in rat liver cytosol was also comparable with that in the high acetyltransferase activity human liver cytosol. However, the level of O-acetyltransferase-dependent bioactivation of N-OH-A alpha C in mouse liver cytosol was comparable with that in the low acetyltransferase activity human liver cytosol. In contrast to N-OH-PhIP, bioactivation of N-OH-A alpha C was not inhibited by glutathione S-transferase activity; however, DNA binding of N-acetoxy-A alpha C was inhibited 20% in the presence of GSH. These results suggest that bioactivation of N-OH-A alpha C may be a significant source of DNA damage in human tissues after dietary exposure to AalphaC and that the relative contribution of each pathway to bioactivation or detoxification of N-OH-A alpha C differs significantly from other N-hydroxy heterocyclic or aromatic amines. JF - Carcinogenesis AU - King, R S AU - Teitel, C H AU - Kadlubar, F F AD - Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 1347 EP - 1354 VL - 21 IS - 7 SN - 0143-3334, 0143-3334 KW - Carbolines KW - 0 KW - Carcinogens KW - Isoenzymes KW - N-hydroxy-2-aminocarboline KW - Recombinant Proteins KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - DNA KW - 9007-49-2 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Arylsulfotransferase KW - EC 2.8.2.1 KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - DNA -- metabolism KW - Humans KW - Glutathione Transferase -- metabolism KW - Liver -- metabolism KW - Mice KW - Arylamine N-Acetyltransferase -- metabolism KW - Isoenzymes -- metabolism KW - Rats KW - Mice, Inbred Strains KW - Acetylation KW - Rats, Inbred F344 KW - Cattle KW - Recombinant Proteins -- metabolism KW - Biotransformation KW - In Vitro Techniques KW - Adenosine Triphosphate -- metabolism KW - Arylsulfotransferase -- metabolism KW - Arylamine N-Acetyltransferase -- genetics KW - Carbolines -- pharmacokinetics KW - Carcinogens -- pharmacokinetics KW - Carbolines -- chemical synthesis KW - Carcinogens -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71218081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=In+vitro+bioactivation+of+N-hydroxy-2-amino-alpha-carboline.&rft.au=King%2C+R+S%3BTeitel%2C+C+H%3BKadlubar%2C+F+F&rft.aulast=King&rft.aufirst=R&rft.date=2000-07-01&rft.volume=21&rft.issue=7&rft.spage=1347&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-17 N1 - Date created - 2000-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mu-class GSTs are responsible for aflatoxin B(1)-8, 9-epoxide-conjugating activity in the nonhuman primate macaca fascicularis liver. AN - 71212972; 10869451 AB - Mice are resistant to the carcinogenic effects of the mycotoxin aflatoxin B(1) (AFB(1)) because they constitutively express an alpha-class glutathione S-transferase (mGSTA3-3) that has high (approximately 200,000 pmol/min/mg) activity toward aflatoxin B(1)-8, 9-epoxide (AFBO). Rats do not constitutively express a GST with high AFBO-conjugating activity and are sensitive to AFB(1)-induced hepatocarcinogenesis. Constitutively expressed human hepatic alpha-class GSTs (hGSTA1-1 and hGSTA2-2) possess little or no AFBO-detoxifying activity (<2 pmol/min/mg). Recently, we found that the nonhuman primate, Macaca fascicularis (Mf), exhibits significant (approximately 300 pmol/min/mg) constitutive hepatic GST activity towards AFBO. To determine which specific GST isoenzyme(s) is (are) responsible for this activity, MF: GSTs were purified from liver tissue and characterized and, Mf mu-class GST cDNAs were cloned by reverse transcriptase-coupled polymerase chain reaction (RT-PCR). Purification by glutathione agarose (GSHA) affinity chromatography yielded a protein, GSHA-GST, that exhibited relatively high AFBO-conjugating activity (239 pmol/min/mg) compared to other GST-containing peaks. Western blotting and enzymatic activity analyses revealed that GSHA-GST belongs to the mu class. Two distinct mu-class GST cDNAs, mfaGSTM1 (GenBank accession # AF200709) and mfaGSTM2 (GenBank accession # AF200710), were generated by RT-PCR. CDNA-derived amino acid sequence analysis revealed that mfaGSTM1 and mfaGSTM2 share 97% and 96% homology with the human mu-class GSTs hGSTM4 and hGSTM2, respectively. In contrast to recombinant mfaGSTM1-1, which had no detectable AFBO-conjugating activity, mfaGSTM2-2 exhibited this activity at 333 pmol/min/mg. Activity profiles for the stereoisomers exo- and endo-AFBO, and of 1-chloro-2,4-dinitrobenzene of the purified protein GSHA-GST and recombinant mfaGSTM2-2, suggested that they are two distinct enzymes. Our results indicate that, in contrast to rodents, mu-class GSTs are responsible for the majority of AFBO-conjugating activity in the liver of Macaca fascicularis. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wang, C AU - Bammler, T K AU - Guo, Y AU - Kelly, E J AU - Eaton, D L AD - National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Dr., HFT-100, Jefferson, Arkansas 72079. Roosevelt Way NE, 100, Seattle, Washington 981. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 26 EP - 36 VL - 56 IS - 1 SN - 1096-6080, 1096-6080 KW - Carcinogens KW - 0 KW - DNA, Complementary KW - Disaccharides KW - RNA, Messenger KW - O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate KW - 102304-70-1 KW - aflatoxin B1-2,3-oxide KW - 42583-46-0 KW - Chondroitin Sulfates KW - 9007-28-7 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Chromatography, Affinity KW - Animals KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - DNA, Complementary -- metabolism KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Cloning, Molecular KW - Chondroitin Sulfates -- genetics KW - Disaccharides -- genetics KW - Liver -- enzymology KW - Macaca fascicularis KW - Aflatoxin B1 -- analogs & derivatives KW - Chondroitin Sulfates -- isolation & purification KW - Chondroitin Sulfates -- metabolism KW - Disaccharides -- metabolism KW - Aflatoxin B1 -- metabolism KW - Carcinogens -- metabolism KW - Disaccharides -- isolation & purification KW - Disaccharides -- classification KW - Chondroitin Sulfates -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71212972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Mu-class+GSTs+are+responsible+for+aflatoxin+B%281%29-8%2C+9-epoxide-conjugating+activity+in+the+nonhuman+primate+macaca+fascicularis+liver.&rft.au=Wang%2C+C%3BBammler%2C+T+K%3BGuo%2C+Y%3BKelly%2C+E+J%3BEaton%2C+D+L&rft.aulast=Wang&rft.aufirst=C&rft.date=2000-07-01&rft.volume=56&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-10 N1 - Date created - 2000-08-10 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF200709; GENBANK; AF200710 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vinyl chloride; still a cause for concern AN - 52274964; 2001-007749 AB - Vinyl chloride (VC) is both a known carcinogen and a regulated chemical, and its production capacity has almost doubled over the last 20 years, currently 27 million tons/year worldwide. According to recent reports it is still a cause for concern. VC has been found as a degradation product of chloroethylene solvents (perchloroethylene and trichloroethylene) and in landfill gas and groundwater at concentrations up to 200 mg/m (super 3) and 10 mg/L, respectively. Worldwide occupational exposure to VC still seems to be high in some countries (e.g., averages of approximately 1,300 mg/m (super 3) until 1987 in one factory), and exposure may also be high in others where VC is not regulated. By combining the most relevant epidemiologic studies from several countries, we observed a 5-fold excess of liver cancer, primarily because of a 45-fold excess risk from angiosarcoma of the liver (ASL). The number of ASL cases reported up to the end of 1998 was 197 worldwide. The average latency for ASL is 22 years. Some studies show a small excess risk for hepatocellular carcinoma, and others suggest a possible risk of brain tumors among highly exposed workers. Lung cancer, lymphomas, or leukemia do not seem to be related to VC exposure according to recent results. The mutation spectra observed in rat and human liver tumors (ASL and/or hepatocellular carcinoma) that are associated with exposure to VC are clearly distinct from those observed in sporadic liver tumors or hepatic tumors that are associated with other exposures. In rats, the substitution mutations found at A:T base pairs in the ras and p53 genes are consistent with the promutagenic properties of the DNA adduct 1,N (super 6) -ethenoadenine formed from VC metabolites. Risk assessments derived from animal studies seem to overestimate the actual risk of cancer when comparing estimated and reported cases of ASL. JF - Environmental Health Perspectives AU - Kielhorn, Janet AU - Melber, Christine AU - Wahnschaffe, Ulrich AU - Aitio, Antero AU - Mangelsdorf, Inge Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 579 EP - 588 PB - U. S. Department of Health and Human Services, Public Health Service, Research Triangle Park, NC VL - 108 IS - 7 SN - 0091-6765, 0091-6765 KW - vinyl chloride KW - soils KW - metabolites KW - chlorinated hydrocarbons KW - degradation KW - medical geology KW - pollutants KW - landfills KW - pollution KW - chemical waste KW - remediation KW - carcinogens KW - organic compounds KW - solvents KW - toxicity KW - DNA KW - halogenated hydrocarbons KW - risk assessment KW - trichloroethylene KW - waste disposal KW - water resources KW - kinetics KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52274964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Vinyl+chloride%3B+still+a+cause+for+concern&rft.au=Kielhorn%2C+Janet%3BMelber%2C+Christine%3BWahnschaffe%2C+Ulrich%3BAitio%2C+Antero%3BMangelsdorf%2C+Inge&rft.aulast=Kielhorn&rft.aufirst=Janet&rft.date=2000-07-01&rft.volume=108&rft.issue=7&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ L2 - http://www.jstor.org/journals/00916765.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 151 N1 - PubXState - NC N1 - Document feature - illus. incl. 9 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carcinogens; chemical waste; chlorinated hydrocarbons; degradation; DNA; halogenated hydrocarbons; kinetics; landfills; medical geology; metabolites; organic compounds; pollutants; pollution; remediation; risk assessment; soils; solvents; toxicity; trichloroethylene; vinyl chloride; waste disposal; water resources ER - TY - JOUR T1 - Lipid lather removes metals AN - 52272482; 2001-007748 JF - Environmental Health Perspectives AU - Frazer, Lance Y1 - 2000/07// PY - 2000 DA - July 2000 SP - A310 EP - A323 PB - U. S. Department of Health and Human Services, Public Health Service, Research Triangle Park, NC VL - 108 IS - 7 SN - 0091-6765, 0091-6765 KW - soils KW - hazardous waste KW - water quality KW - toxic materials KW - fatty acids KW - medical geology KW - lipids KW - arsenic KW - soil treatment KW - pollution KW - lead KW - biosurfactants KW - equilibrium KW - remediation KW - carcinogens KW - organic compounds KW - organic acids KW - decontamination KW - metals KW - surfactants KW - chemical properties KW - heavy metals KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52272482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Lipid+lather+removes+metals&rft.au=Frazer%2C+Lance&rft.aulast=Frazer&rft.aufirst=Lance&rft.date=2000-07-01&rft.volume=108&rft.issue=7&rft.spage=A310&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ L2 - http://www.jstor.org/journals/00916765.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - PubXState - NC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - arsenic; biosurfactants; carcinogens; chemical properties; decontamination; equilibrium; fatty acids; hazardous waste; heavy metals; lead; lipids; medical geology; metals; microorganisms; organic acids; organic compounds; pollution; remediation; soil treatment; soils; surfactants; toxic materials; water quality ER - TY - JOUR T1 - Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years AN - 18476973; 5444891 AB - High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumococcal serotypes before the booster dose. JF - Clinical Infectious Diseases AU - Miernyk, K M AU - Parkinson, A J AU - Rudolph, K M AU - Petersen, K M AU - Bulkow, L R AU - Greenberg, D P AU - Ward, JI AU - Brenneman, G AU - Reid, R AU - Santosham, M AD - Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services, Anchorage, Alaska, USA Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 34 EP - 41 VL - 31 IS - 1 SN - 1058-4838, 1058-4838 KW - man KW - Microbiology Abstracts B: Bacteriology KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18476973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Immunogenicity+of+a+Heptavalent+Pneumococcal+Conjugate+Vaccine+in+Apache+and+Navajo+Indian%2C+Alaska+Native%2C+and+Non-Native+American+Children+Aged+%26lt%3B2+Years&rft.au=Miernyk%2C+K+M%3BParkinson%2C+A+J%3BRudolph%2C+K+M%3BPetersen%2C+K+M%3BBulkow%2C+L+R%3BGreenberg%2C+D+P%3BWard%2C+JI%3BBrenneman%2C+G%3BReid%2C+R%3BSantosham%2C+M&rft.aulast=Miernyk&rft.aufirst=K&rft.date=2000-07-01&rft.volume=31&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - A comprehensive systematic approach to identification of influenza A virus genotype using RT-PCR and RFLP AN - 17619728; 4757138 AB - Amplification of influenza A virus gene segments by reverse transcription-polymerase chain reaction (RT-PCR) can be combined with enzymatic digestion to reveal unique restriction fragment length polymorphisms specific for H1N1 and H3N2 subtype viruses. We have used the method to provide a rapid, specific and reproducible identification of the genotype of high-growth influenza reassortants derived from A/Puerto Rico/8/34 (PR8). Digestion of the gene segments amplified from wild-type viruses, PR8 and reassortants at sites unique to either the wild-type strain or to PR8 provided positive, unambiguous identification of the origin of each of the internal genes, and distinguished the internal genes of both H1N1 and H3N2 strains from those of PR8. This method has also permitted us to quickly confirm that reassorting has occurred and to optimize the selection of reassortant clones with maximum number of PR8 internal genes. Since the method can detect 1-10% of a second strain in a mixed population, the method can also be used to detect samples containing more than one viral subtype and to assess the purity of influenza viruses used for manufacturing vaccines. JF - Journal of Virological Methods AU - Offringa, D P AU - Tyson-Medlock, V AU - Ye, Z AU - Levandowski, R A AD - The Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 463, 20852 Rockville, MD USA Y1 - 2000/07/01/ PY - 2000 DA - 2000 Jul 01 SP - 15 EP - 24 PB - Elsevier VL - 88 IS - 1 SN - 0166-0934, 0166-0934 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Genotyping KW - Influenza A virus KW - Genetic analysis KW - Restriction fragment length polymorphism KW - Polymerase chain reaction KW - Vaccines KW - A 01114:Viruses KW - V 22010:Virus taxonomy & classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17619728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=A+comprehensive+systematic+approach+to+identification+of+influenza+A+virus+genotype+using+RT-PCR+and+RFLP&rft.au=Offringa%2C+D+P%3BTyson-Medlock%2C+V%3BYe%2C+Z%3BLevandowski%2C+R+A&rft.aulast=Offringa&rft.aufirst=D&rft.date=2000-07-01&rft.volume=88&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2FS0166-0934%2800%2900180-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Influenza A virus; Genetic analysis; Genotyping; Restriction fragment length polymorphism; Polymerase chain reaction; Vaccines DO - http://dx.doi.org/10.1016/S0166-0934(00)00180-4 ER - TY - JOUR T1 - Chronic dopaminergic signaling in the basal ganglia: a damage perspective on kinases and fos-related antigens AN - 17615261; 4751089 AB - Specific protein phosphorylation pathways have been shown to play a role in cellular adaptation responses underlying addiction to psychostimulants such as methamphetamine and cocaine. Transcriptional regulation through fos-related antigens constitutes one element through which these dopaminergic agonists exert their persistent actions. In addition to their addictive properties, amphetamines are known to damage dopaminergic nerve terminals. Although not widely appreciated, protein phosphorylation cascades and fos-related antigens also may play a role in the neurotoxic actions of substituted amphetamines such as methamphetamine. Here we document the involvement of the dopaminoceptive phosphoprotein, DARPP-32, the fos-related antigen, FRA-2, and the growth associated protein kinase, MAP kinase, in the neurotoxic action of known dopaminergic neurotoxicants, including methamphetamine. The addictive and neurotoxic properties of psychostimulants may share some molecular signaling mechanisms. JF - Addiction Biology AU - O'Callaghan, J P AU - Miller, D B AU - Pennypacker, K R AD - Centers for Disease Control and Prevention, NIOSH/HELD/TMBB (MS-3014), 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, jdo5@cdc.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 369 EP - 376 VL - 5 IS - 3 SN - 1355-6215, 1355-6215 KW - DARPP-32 protein KW - Fra-2 protein KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - MAP kinase KW - Psychomotor stimulants KW - Fos protein KW - Dopamine KW - Neurotoxicity KW - Amphetamine KW - Basal ganglia KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17615261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=Chronic+dopaminergic+signaling+in+the+basal+ganglia%3A+a+damage+perspective+on+kinases+and+fos-related+antigens&rft.au=O%27Callaghan%2C+J+P%3BMiller%2C+D+B%3BPennypacker%2C+K+R&rft.aulast=O%27Callaghan&rft.aufirst=J&rft.date=2000-07-01&rft.volume=5&rft.issue=3&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dopamine; Fos protein; Neurotoxicity; Psychomotor stimulants; Amphetamine; Basal ganglia; MAP kinase ER - TY - JOUR T1 - Prior exposure to a behaviorally sensitizing regimen of d-methamphetamine does not alter the striatal dopaminergic damage induced by a neurotoxic regimen AN - 17613851; 4751088 AB - Repeated exposure to psychostimulant drugs such as d-methamphetamine (d-METH) and cocaine can be associated with extremely long-lived changes in dopamine systems at the behavioral, cellular and molecular level. Sensitization or an enhanced response to drug exposure is one such change. Investigations of these phenomena at the cellular and molecular levels are being conducted in the hope that this will aid in understanding how such adaptations might contribute to drug addition. Repeated exposure to certain amphetamines can also result in damage to dopaminergic pathways. Although some of the same molecular adaptations and mechanisms are suspected to occur or play a role in the neurotoxic sequelae associated with psychostimulant exposure, there has been little attempt to examine the relationship among these phenomena. Here we utilized C57BL/6J female mice to examine whether exposure to a sensitizing regimen of d-METH would impact the degree of neural injury induced by a subsequent exposure to a neurotoxic regimen of the same psychostimulant. Every other day exposure to d-METH (1.0 or 2.0 mg/kg) for 11 days produced a behavioral sensitization, as evidenced by a significant increase in the degree of locomotor activity induced by each subsequent exposure to d-METH. Following a 5-day period of no drug exposure sensitized mice were given a neurotoxic regiment of d-METH (a total of four injections of 10.0 mg/kg, one every 2 hours) and striatal tissue examined 72 hours later. All groups, whether drug-naive or sensitized previously to d-METH, showed exactly the same degree of dopaminergic striatal damage induced by a neurotoxic regimen. This was evidenced by equivalent reductions in dopamine and elevations in GFAP protein, a marker of astrocytic response to injury, GFAP. The inability of a sensitizing regimen to either exacerbate or lessen the neurotoxic actions of the same compound suggests that the molecular and cellular control of these two aspects of psychostimulant exposure may differ. JF - Addiction Biology AU - Miller, D B AU - O'Callaghan, J P AU - Johnson, E A AD - Chronic Stress and Neurotoxicology Laboratory, Toxicology and Molecular Biology Branch, CDC/NIOSH-HELD, 1095 Willowdale Road, Morgantown, WV 26505, USA, dum6@cdc.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 361 EP - 367 VL - 5 IS - 3 SN - 1355-6215, 1355-6215 KW - mice KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Methamphetamine KW - Dopamine KW - Neurotoxicity KW - Neostriatum KW - Sensitization KW - Brain KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17613851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=Prior+exposure+to+a+behaviorally+sensitizing+regimen+of+d-methamphetamine+does+not+alter+the+striatal+dopaminergic+damage+induced+by+a+neurotoxic+regimen&rft.au=Miller%2C+D+B%3BO%27Callaghan%2C+J+P%3BJohnson%2C+E+A&rft.aulast=Miller&rft.aufirst=D&rft.date=2000-07-01&rft.volume=5&rft.issue=3&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Methamphetamine; Sensitization; Neostriatum; Dopamine; Neurotoxicity; Brain ER - TY - JOUR T1 - Role of peroxynitrite in methamphetamine-induced dopaminergic neurotoxicity and sensitization in mice AN - 17612927; 4751085 AB - Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In the present study, we examined the role of the neuronal nitric oxide synthase (nNOS), susceptibility of nNOS knockout (KO) mice and sensitization to psychostimulants after neurotoxic doses of METH. Male Swiss Webster mice were treated with or without 7-nitroindazole (7-NI) along with METH (5 mg/kg,ip,q 3 h x 3) and were sacrificed 72 h after the last METH injection. Dopamine (DA) and dopamine transporter (DAT) binding sites were determined in striatum from saline and METH-treated animals. 7-NI completely protected against the depletion of DA, and DAT in striatum. In follow-up experiments nNOS KO mice along with appropriate control (C57BL/6N, SV129 and B6JSV129) mice were treated with METH (5 mg/kg,ip,q 3 h x 3) and were sacrificed 72 h after dosing. This schedule of METH administrations resulted in only 10-20% decrease in tissue content of DA and no apparent change in the number of DAT binding sites in nNOS KO mice. However, this regime of METH resulted in a significant decrease in the content of DA as well as DAT binding sites in the wild-type animals. Pre-exposure to single or multiple doses of METH resulted in a marked locomotion sensitization in response to METH. However, the nNOS KO mice show no sensitization in response to METH after single or multiple injections of METH. Therefore, these studies strongly suggest the role of peroxynitrite, nNOS and DA system in METH-induced neurotoxicity and behavioral sensitization. JF - Addiction Biology AU - Ali, S F AU - Haung, Paul AU - Itzhak, Y AD - Head, Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA, sali@nctr.fda.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 331 EP - 341 VL - 5 IS - 3 SN - 1355-6215, 1355-6215 KW - mice KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Peroxynitrite KW - Nitric-oxide synthase KW - Methamphetamine KW - Dopamine KW - Neostriatum KW - Sensitization KW - Neurotoxicity KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17612927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=Role+of+peroxynitrite+in+methamphetamine-induced+dopaminergic+neurotoxicity+and+sensitization+in+mice&rft.au=Ali%2C+S+F%3BHaung%2C+Paul%3BItzhak%2C+Y&rft.aulast=Ali&rft.aufirst=S&rft.date=2000-07-01&rft.volume=5&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Peroxynitrite; Methamphetamine; Neurotoxicity; Sensitization; Dopamine; Nitric-oxide synthase; Neostriatum ER - TY - JOUR T1 - Identification of a CHO cell-elongating factor produced by Vibrio cholerae O1 AN - 17609504; 4743250 AB - Vibrio cholerae strains with all known toxin genes deleted or inactivated still cause diarrhoea in some volunteers, suggesting the presence of an unknown virulence factor or factors. Lysozyme-EDTA treated cells of JBK70, a genetically manipulated cholera toxin negative strain of Vibrio cholerae O1, biotype El Tor, release a factor that causes elongation of Chinese hamster ovary (CHO) cells. CHO cell-elongating toxin (Cef) was purified by FPLC chromatography (anion exchange; Q Sepharose High Performance) followed by 2D electrophoresis (isoelectric focusing gel, IEF; pH 3-9 and SDS-PAGE, 8-25% gradient gel). Partly purified toxin (anion exchange or IEF-eluted concentrate) caused fluid accumulation in sealed infant mice suggesting that Cef shows some properties of an enterotoxin. On SDS-PAGE (8-25%) and IEF (pH 2.5-5.0) gels, CHO cell activity was associated with a single band at 85 kDa and a pI of 3.8, respectively. A unique amino terminal sequence, XGDETNSSGASTEVVYESYIQQ, was determined by automated Edman degradation of gel-purified protein. The unique molecular mass, N-terminal sequence and activity on CHO cells indicate that this factor is not zonula occludens toxin (Zot) or accessory cholera enterotoxin (Ace) or the Hly A haemolysin. Partly purified Cef did not increase cyclic AMP or prostaglandin E sub(2)levels in CHO cells which suggests that its mechanism of action differs from that of cholera toxin. JF - Microbial Pathogenesis AU - McCardell, BA AU - Kothary, M H AU - Hall, R H AU - Sathyamoorthy, V AD - U.S. Food and Drug Administration, Division of Virulence Assessment, 200 C. St. SW, Washington, DC 20204, U.S.A., bmccarde@bangate.fda.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 1 EP - 8 PB - Academic Press VL - 29 IS - 1 SN - 0882-4010, 0882-4010 KW - elongation factor KW - Microbiology Abstracts B: Bacteriology KW - Lysozyme KW - Vibrio cholerae KW - CHO cells KW - Enterotoxins KW - Toxins KW - Edetic acid KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17609504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Identification+of+a+CHO+cell-elongating+factor+produced+by+Vibrio+cholerae+O1&rft.au=McCardell%2C+BA%3BKothary%2C+M+H%3BHall%2C+R+H%3BSathyamoorthy%2C+V&rft.aulast=McCardell&rft.aufirst=BA&rft.date=2000-07-01&rft.volume=29&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1006%2Fmpat.2000.0361 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vibrio cholerae; Lysozyme; Edetic acid; Enterotoxins; Toxins; CHO cells DO - http://dx.doi.org/10.1006/mpat.2000.0361 ER - TY - JOUR T1 - Slip and fall-related injuries in relation to environmental cold and work location in above-ground coal mining operations AN - 17604687; 4752744 AB - The association between slip and fall-related injuries and environmental temperature was examined for mostly enclosed (inside vehicles, machinery, or buildings), outdoor (outside, not enclosed), and enclosed/outdoor jobs in the coal mining industry to see if differences existed among the three work locations that had varying exposure to cold temperatures. Temperature data from the National Climatic Data Center and injury data from the Mine Safety and Health Administration were evaluated from 1985-1990 for seven states. Proportionate methods were used to examine the relationship between slips and falls and temperature. Proportionate injury ratios of slips and fall-related injuries increased as temperature declined for all three work locations. Proportion of slips and fall-related injuries that occurred while running/walking increased with declining temperature, with the ground outside as the most common source of these injuries. Outside movement becomes a greater hazard at freezing temperatures for workers in all locations, not just outdoor workers. Any intervention methods geared toward reducing injury incidents facilitated by cold weather must also be directed toward workers who spend time in more enclosed locations. JF - American Journal of Industrial Medicine AU - Bell, J L AU - Gardner, LI AU - Landsittel, D P AD - National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, M/S P1133, Morgantown, WV 26505, USA, jbell@cdc.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 40 EP - 48 VL - 38 IS - 1 SN - 0271-3586, 0271-3586 KW - cold KW - falls KW - slips KW - Health & Safety Science Abstracts KW - Accidents KW - Injuries KW - Occupational safety KW - Mining KW - Coal KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17604687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Slip+and+fall-related+injuries+in+relation+to+environmental+cold+and+work+location+in+above-ground+coal+mining+operations&rft.au=Bell%2C+J+L%3BGardner%2C+LI%3BLandsittel%2C+D+P&rft.aulast=Bell&rft.aufirst=J&rft.date=2000-07-01&rft.volume=38&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2F1097-0274%28200007%2938%3A13.0.CO%3B2-F LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Accidents; Occupational safety; Injuries; Coal; Mining DO - http://dx.doi.org/10.1002/1097-0274(200007)38:1<40::AID-AJIM5>3.0.CO;2-F ER - TY - JOUR T1 - A retrospective job exposure matrix for estimating exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin AN - 17604537; 4752743 AB - A job exposure matrix was developed to estimate the 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure of 3,538 workers who produced 2,4,5-trichlorophenol and its derivatives. Daily TCDD exposure scores that were plant, process, and period specific were estimated for each job title as the product of 1) the concentration of TCDD ( mu g/g); 2) a qualitative factor to account for the extent of worker contact and 3) time exposed to TCDD contamination. Daily scores were summed to compute individual cumulative TCDD exposure scores. Daily TCDD exposure scores ranged from 0.001 to 1,250. Cumulative TCDD scores ranged from 0.002 to 1,559,430. The 393 workers with records of chloracne in the TCDD exposure cohort (11%) had markedly higher cumulative scores than those with no record of chloracne (a median score of 11,546 vs. 77). The cumulative TCDD exposure scores incorporate both duration and level of exposure, and permit the relative ranking of worker exposures for the evaluation of exposure-response relationships between TCDD exposure and mortality in an updated cohort study analysis. JF - American Journal of Industrial Medicine AU - Piacitelli, L AU - Marlow, D AU - Fingerhut, M AU - Steenland, K AU - Sweeney, M H AD - NIOSH, 4676 Columbia Parkway, MS R14, Cincinnati, OH 45226, USA, lap1@cdc.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 28 EP - 39 VL - 38 IS - 1 SN - 0271-3586, 0271-3586 KW - chronic exposure KW - dose-response effects KW - man KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Mathematical models KW - Dose-response effects KW - TCDD KW - Occupational exposure KW - X 24222:Analytical procedures KW - X 24153:Metabolism KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17604537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+retrospective+job+exposure+matrix+for+estimating+exposure+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin&rft.au=Piacitelli%2C+L%3BMarlow%2C+D%3BFingerhut%2C+M%3BSteenland%2C+K%3BSweeney%2C+M+H&rft.aulast=Piacitelli&rft.aufirst=L&rft.date=2000-07-01&rft.volume=38&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2F1097-0274%28200007%2938%3A13.3.CO%3B2-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - TCDD; Occupational exposure; Dose-response effects; Mortality; Mathematical models DO - http://dx.doi.org/10.1002/1097-0274(200007)38:1<28::AID-AJIM4>3.3.CO;2-7 ER - TY - JOUR T1 - Prevalence of Ehrlichia ewingii in Amblyomma americanum in North Carolina AN - 17566922; 4748042 AB - Ticks as vectors of Ehrlichia parasites have been the subject of study in North Carolina since 1993. Recently, Ehrlichia ewingii, which causes canine granulocytic ehrlichiosis, was documented as causing human illness in Missouri. Previously, the Lone Star tick, Amblyomma americanum, was confirmed as the vector of this parasite in dogs. Accordingly, in 1999, we focused our efforts on determining the presence and infection rate of E. ewingii in A. americanum. Infection rates for E. ewingii were low in adult A. americanum ticks, 0.4% (1 of 245) in females and 0.9% (2 of 217) in males, and a pool-positive rate of 4.7% (5 of 106) was obtained when 1,308 nymphs in 106 pools were tested for E. ewingii. However, a minimum field infection rate for the nymphs was 0.4% (5 of 1,308 ticks). JF - Journal of Clinical Microbiology AU - Wolf, L AU - McPherson, T AU - Harrison, B AU - Engber, B AU - Anderson, A AU - White, P AD - State Laboratory of Public Health, N.C. Department of Health and Human Services, Raleigh, NC 27611, USA Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 2795 VL - 38 IS - 7 SN - 0095-1137, 0095-1137 KW - Acari KW - USA, North Carolina KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology KW - Nymphs KW - Geographical distribution KW - Genotyping KW - Ixodidae KW - Vector-borne diseases KW - Vectors KW - Adults KW - Disease transmission KW - Amblyomma americanum KW - Ehrlichia ewingii KW - DNA KW - Polymerase chain reaction KW - J 02870:Invertebrate bacteriology KW - Z 05206:Medical & veterinary entomology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17566922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Prevalence+of+Ehrlichia+ewingii+in+Amblyomma+americanum+in+North+Carolina&rft.au=Wolf%2C+L%3BMcPherson%2C+T%3BHarrison%2C+B%3BEngber%2C+B%3BAnderson%2C+A%3BWhite%2C+P&rft.aulast=Wolf&rft.aufirst=L&rft.date=2000-07-01&rft.volume=38&rft.issue=7&rft.spage=2795&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ehrlichia ewingii; Amblyomma americanum; Ixodidae; Disease transmission; Vectors; Vector-borne diseases; DNA; Polymerase chain reaction; Genotyping; Adults; Nymphs; Geographical distribution ER - TY - JOUR T1 - Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins AN - 17557802; 4747885 AB - The fungus Stachybotrys chartarum has been implicated in cases of nonspecific indoor air quality complaints in adults and in cases of pulmonary hemorrhaging in infants. The effects that have been described have been attributed to mycotoxins. Previous dose-effect studies focused on exposure to a single mycotoxin in a solvent, a strategy which is unlikely to accurately characterize the effects of inhaled spores. In this study we examined the role of mycotoxins in the pulmonary effects caused by S. chartarum spores and the dose dependency of these effects. S. chartarum spores were extracted in methanol to reduce the mycotoxin content of the spores. Then either untreated (toxin-containing) or methanol-extracted S. chartarum spores were intratracheally instilled into male 10-week-old Charles River-Dawley rats. After 24 h, the lungs were lavaged, and the bronchoalveolar lavage fluid was analyzed to determine differences in lactic dehydrogenase, albumin, hemoglobin, myeloper-oxidase, and leukocyte differential counts. Weight change was also monitored. Our data show that methanol extraction dramatically reduced the toxicity of S. chartarum spores. No statistically significant effects were observed in the bronchoalveolar lavage fluids of the animals that were treated with methanol-extracted spores at any dose. Conversely, dose-dependent effects of the toxin-containing spores were observed when we examined the lactic dehydrogenase, albumin, and hemoglobin concentrations, the polymorphonuclear leukocyte counts, and weight loss. Our findings show that a single, intense exposure to toxin-containing S. chartarum spores results in pulmonary inflammation and injury in a dose-dependent manner. Importantly, the effects are related to methanol-soluble toxins in the spores. JF - Applied and Environmental Microbiology AU - Rao, CY AU - Brain, J D AU - Burge, HA AD - NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA, cnr3@cdc.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 2817 EP - 2821 VL - 66 IS - 7 SN - 0099-2240, 0099-2240 KW - extraction KW - animal models KW - rats KW - Lactate dehydrogenase KW - Myeloperoxidase KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Leukocytes KW - Methanol KW - Stachybotrys chartarum KW - Hemoglobin KW - Mycotoxins KW - Lung KW - Albumin KW - Spores KW - X 24171:Microbial KW - K 03082:Mycotoxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17557802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Reduction+of+pulmonary+toxicity+of+Stachybotrys+chartarum+spores+by+methanol+extraction+of+mycotoxins&rft.au=Rao%2C+CY%3BBrain%2C+J+D%3BBurge%2C+HA&rft.aulast=Rao&rft.aufirst=CY&rft.date=2000-07-01&rft.volume=66&rft.issue=7&rft.spage=2817&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.7.2817-2821.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stachybotrys chartarum; Mycotoxins; Spores; Methanol; Lung; Albumin; Hemoglobin; Leukocytes DO - http://dx.doi.org/10.1128/AEM.66.7.2817-2821.2000 ER - TY - JOUR T1 - Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussis AN - 17555019; 4747784 AB - We examined the structural components of pertussis toxin that are required for efficient export from Bordetella pertussis via the Ptl system, a member of the type IV family of macromolecular transporters. First, we constructed a strain of B. pertussis that contains a functional Ptl system but does not produce pertussis toxin. Plasmids which express either the S1 subunit or the B oligomer were then introduced into this strain. We found that the B oligomer of the toxin is not secreted in the absence of the S1 subunit. Conversely, the S1 subunit is also not secreted by a Ptl-mediated mechanism in the absence of the B oligomer. Thus, an assembled holotoxin is required for Ptl-mediated export of pertussis toxin from B. pertussis. JF - Infection and Immunity AU - Farizo, K M AU - Huang, Th AU - Burns, D L AD - CBER, FDA HFM-434, Building 29, Room 418, 8800 Rockville Pike, Bethesda, MD 20892, USA, farizo@cber.fda.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 4049 EP - 4054 VL - 68 IS - 7 SN - 0019-9567, 0019-9567 KW - oligomers KW - holotoxin KW - Ptl protein KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Pertussis KW - Plasmids KW - Toxins KW - Protein structure KW - Bordetella pertussis KW - J 02822:Biosynthesis and physicochemical properties KW - X 24171:Microbial KW - A 01023:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17555019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Importance+of+holotoxin+assembly+in+Ptl-mediated+secretion+of+pertussis+toxin+from+Bordetella+pertussis&rft.au=Farizo%2C+K+M%3BHuang%2C+Th%3BBurns%2C+D+L&rft.aulast=Farizo&rft.aufirst=K&rft.date=2000-07-01&rft.volume=68&rft.issue=7&rft.spage=4049&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.7.4049-4054.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bordetella pertussis; Toxins; Pertussis; Protein structure; Plasmids DO - http://dx.doi.org/10.1128/IAI.68.7.4049-4054.2000 ER - TY - JOUR T1 - Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos AN - 17549839; 4735842 AB - Malignant mesothelioma is known to be associated with asbestos exposure. However, the mechanism of mesothelial carcinogenesis in relation to the activation of proto-oncogenes or inactivation of tumor suppressor genes remains unclear. In this study, the PCR-Primer Introduced Restriction Site (PCR-PIRS) assay was employed to examine mutations in the K-ras proto-oncogene in mesothelioma tissues from workers exposed to asbestos and from rats treated with asbestos. Mutations in exons 5-8 of the p53 tumor suppressor gene were determined by direct DNA sequence analysis. Results of the PCR-PIRS analysis revealed no mutations in codons 12, 13 or 61 of the K-ras gene in any of the 17 human or 22 rat mesothelioma tissue samples. These results were confirmed by direct DNA sequence analysis. No mutations were found in exons 5-8 of the p53 gene in any of the mesothelioma tissue samples analyzed. These results and the results reported by others indicate that the K-ras proto-oncogene and p53 tumor suppressor gene may not play a critical role in the induction of mesothelioma by asbestos either in humans or in rats. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Ni, Z AU - Liu, Y Q AU - Keshava, N AU - Zhou, G AU - Whong, W Z AU - Ong, T M AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, HELD, NIOSH, m/s 3014, 1095 Willowdale Road, 26505-2888 Morgantown, WV USA Y1 - 2000/06/22/ PY - 2000 DA - 2000 Jun 22 SP - 87 EP - 92 PB - Elsevier Science VL - 468 IS - 1 SN - 1383-5718, 1383-5718 KW - man KW - rats KW - K-ras gene KW - mesothelioma KW - p53 gene KW - Genetics Abstracts; Toxicology Abstracts KW - Asbestos KW - Oncogenes KW - Carcinogenesis KW - Mutation KW - X 24155:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17549839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Analysis+of+K-ras+and+p53+mutations+in+mesotheliomas+from+humans+and+rats+exposed+to+asbestos&rft.au=Ni%2C+Z%3BLiu%2C+Y+Q%3BKeshava%2C+N%3BZhou%2C+G%3BWhong%2C+W+Z%3BOng%2C+T+M&rft.aulast=Ni&rft.aufirst=Z&rft.date=2000-06-22&rft.volume=468&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2FS1383-5718%2800%2900043-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Asbestos; Carcinogenesis; Oncogenes; Mutation DO - http://dx.doi.org/10.1016/S1383-5718(00)00043-7 ER - TY - JOUR T1 - Calcitonin gene-related peptide-dependent vascular relaxation of rat aorta. An additional mechanism for nitroglycerin. AN - 71090568; 10799659 AB - We investigated the involvement of calcitonin gene-related peptide (CGRP) in the vasodilatory mechanism of action of nitric oxide (NO) donors. The functional role of CGRP in NO donor-induced vasodilation of isolated rat aortic rings was determined by incubating these drugs with and without CGRP(8-37), a selective CGRP receptor antagonist. CGRP(8-37) (0.63 microM) induced rightward shifts in the vasodilatory concentration-response curves for nitroglycerin (NTG), Piloty's acid (PA), and SIN-1 (linsidomine). The EC(50) values for NTG, PA, and SIN-1 were increased by 8.3-, 5.2-, and 2.3-fold, respectively (P < 0.05). The release of CGRP from rat aorta in response to NTG and PA was measured specifically by radioimmunoassay. Thirty-minute incubations of NTG or PA with rat aorta induced 189.5 and 214.6% increases, respectively, in CGRP release when compared with the control (P < 0.05). The concentration-response curves of sodium nitroprusside (SNP), S-nitroso-acetylpenicillamine (SNAP), tetranitromethane (TNM), diethylamine NO complex (DEA-NO), and diethylenetriamine/nitric oxide adduct (DETA NONOate) were not inhibited significantly by CGRP(8-37) co-incubation (P 0.05). NO donors also were incubated with aortic strips, and NTG and PA alone induced significant formation of hydroxylamine, a NO(-) metabolite (232.4 and 364.9%, respectively, P < 0.05). These results indicate that only NTG and PA, and to a lesser extent SIN-1, stimulate the release of CGRP from the rat aorta, which subsequently contributes to the vasodilatory activity of these agents. The hydroxylamine formation suggests a possible link between NO(-) generation and CGRP release from the vascular wall. JF - Biochemical pharmacology AU - Booth, B P AU - Tabrizi-Fard, M A AU - Fung, H AD - Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, NY, USA. boothb@cder.fda.gov Y1 - 2000/06/15/ PY - 2000 DA - 2000 Jun 15 SP - 1603 EP - 1609 VL - 59 IS - 12 SN - 0006-2952, 0006-2952 KW - Nitric Oxide Donors KW - 0 KW - Vasodilator Agents KW - Hydroxylamine KW - 2FP81O2L9Z KW - Calcitonin Gene-Related Peptide KW - 83652-28-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Hydroxylamine -- metabolism KW - Dose-Response Relationship, Drug KW - Aorta KW - Male KW - Nitric Oxide Donors -- pharmacology KW - Calcitonin Gene-Related Peptide -- pharmacology KW - Vasodilation -- drug effects KW - Vasodilator Agents -- pharmacology KW - Calcitonin Gene-Related Peptide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71090568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Calcitonin+gene-related+peptide-dependent+vascular+relaxation+of+rat+aorta.+An+additional+mechanism+for+nitroglycerin.&rft.au=Booth%2C+B+P%3BTabrizi-Fard%2C+M+A%3BFung%2C+H&rft.aulast=Booth&rft.aufirst=B&rft.date=2000-06-15&rft.volume=59&rft.issue=12&rft.spage=1603&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-21 N1 - Date created - 2000-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Infection of B Cell-Deficient Mice with CDC 1551, a Clinical Isolate of Mycobacterium tuberculosis: Delay in Dissemination and Development of Lung Pathology AN - 17546616; 4730192 AB - Long-term survival of mice infected with Mycobacterium tuberculosis is dependent upon IFN- gamma and T cells, but events in early phases of the immune response are not well understood. In this study, we describe a role for B cells during early immune responses to infection with a clinical isolate of M. tuberculosis (CDC 1551). Following a low-dose infection with M. tuberculosis CDC 1551, similar numbers of bacteria were detected in the lungs of both B cell knockout (IgH 6 super(-), BKO) and C57BL/6J (wild-type) mice. However, despite comparable bacterial loads in the lungs, less severe pulmonary granuloma formation and delayed dissemination of bacteria from lungs to peripheral organs were observed in BKO mice. BKO mice reconstituted with naive B cells, but not those given M. tuberculosis-specific Abs, before infection developed pulmonary granulomas and dissemination patterns similar to wild-type animals. Further analysis of lung cell populations revealed greater numbers of lymphocytes, especially CD8 super(+) T cells, macrophages, and neutrophils in wild-type and reconstituted mice than in BKO mice. Thus, less severe lesion formation and delayed dissemination of bacteria found in BKO mice were dependent on B cells, not Abs, and were associated with altered cellular infiltrate to the lungs. These observations demonstrate an important, previously unappreciated, role for B cells during early immune responses to M. tuberculosis infections. JF - Journal of Immunology AU - Bosio, C M AU - Gardner, D AU - Elkins, K L AD - Laboratory of Mycobacteria, DBP/CBER/FDA, 1401 Rockville Pike, HFM431, Rockville, MD 20852, USA, elkins@cber.fda.gov Y1 - 2000/06/15/ PY - 2000 DA - 2000 Jun 15 SP - 6417 EP - 6425 VL - 164 IS - 12 SN - 0022-1767, 0022-1767 KW - mice KW - immunology KW - Mycobacterium tuberculosis KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lymphocytes B KW - Lung KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17546616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Infection+of+B+Cell-Deficient+Mice+with+CDC+1551%2C+a+Clinical+Isolate+of+Mycobacterium+tuberculosis%3A+Delay+in+Dissemination+and+Development+of+Lung+Pathology&rft.au=Bosio%2C+C+M%3BGardner%2C+D%3BElkins%2C+K+L&rft.aulast=Bosio&rft.aufirst=C&rft.date=2000-06-15&rft.volume=164&rft.issue=12&rft.spage=6417&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Lung; Lymphocytes B ER - TY - JOUR T1 - A large insertion in the Shiga-like toxin 2 gene (stx sub(2)) of an Escherichia coli O157:H7 clinical isolate AN - 17605093; 4744198 AB - Six clinical Escherichia coli O157:H7 isolates were epidemiologically linked as part of an outbreak in which the most likely source was undercooked ground beef or cross-contamination from the ground beef to other food products at a Mexican-style restaurant. These cultures were analyzed using molecular genetic, immunological and cytotoxicity procedures. All six isolates were confirmed as E. coli O157:H7 and were indistinguishable by pulsed-field gel electrophoresis using XbaI. The results of polymerase chain reaction (PCR) tests, non-isotopic gene probing, reversed passive latex agglutination (RPLA) kit results and Vero cell assays were consistent for the presence of a functional Shiga-like toxin 1 (Stx 1) protein. All six strains produced a stx sub(2) PCR amplicon product; five strains produced a product which was consistent with the predicted amplicon size and one (SEA 6414) produced a much larger PCR product. The SEA 6414 isolate produced a protein reactive with the RPLA kit anti-Stx 2 antibody but was not cytotoxic to Vero cells. Sequencing of this region revealed that this 1310 bp insertion was very similar to a previously identified IS 1203 sequence and the insertion interrupted the carboxyl end of the coding region of the stx sub(2) gene `A' subunit. JF - International Journal of Food Microbiology AU - Jinneman, K C AU - Weagant, S D AU - Johnson, J M AU - Abbott, S L AU - Hill, W E AU - Tenge, B J AU - Dang, N-L AU - Ramsden, R AU - Omiecinski, C J AD - Seafood Products Research Center, Food and Drug Administration, Bothell, WA 98021-4421, USA, kjinnema@ora.fda.gov Y1 - 2000/06/10/ PY - 2000 DA - 2000 Jun 10 SP - 115 EP - 124 VL - 57 IS - 1-2 SN - 0168-1605, 0168-1605 KW - Shiga-like toxin 2 KW - stx2 gene KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Insertion KW - Escherichia coli KW - Polymerase chain reaction KW - X 24171:Microbial KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17605093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=A+large+insertion+in+the+Shiga-like+toxin+2+gene+%28stx+sub%282%29%29+of+an+Escherichia+coli+O157%3AH7+clinical+isolate&rft.au=Jinneman%2C+K+C%3BWeagant%2C+S+D%3BJohnson%2C+J+M%3BAbbott%2C+S+L%3BHill%2C+W+E%3BTenge%2C+B+J%3BDang%2C+N-L%3BRamsden%2C+R%3BOmiecinski%2C+C+J&rft.aulast=Jinneman&rft.aufirst=K&rft.date=2000-06-10&rft.volume=57&rft.issue=1-2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2FS0168-1605%2800%2900237-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Polymerase chain reaction; Insertion DO - http://dx.doi.org/10.1016/S0168-1605(00)00237-3 ER - TY - JOUR T1 - Effects of simulated pulmonary surfactant on the cytotoxicity and DNA-damaging activity of respirable quartz and kaolin. AN - 71258710; 10884165 AB - Respirable-sized quartz and kaolin dusts were pretreated with simulated pulmonary surfactant dispersions of dipalmitoyl phosphatidylcholine (DPPC) in saline to model the conditioning of particles depositing in alveolar regions of the lung. DPPC-treated and untreated dusts were used to challenge lavaged rat pulmonary alveolar macrophages in vitro. Cytotoxicity was determined over a 5-d period using both total and viable cell counts from a fluorescence-based viability assay. DNA damage, as an indication of genotoxicity, was determined over a 7-d period by the single-cell gel electrophoresis assay. Untreated quartz and kaolin both expressed a significant and potent cytotoxicity, which increased with concentration and time. DPPC-surfactant pretreatment delayed significant expression of this cytotoxicity until 3 to 5 d after challenge. Untreated quartz also caused DNA damage, which increased with concentration and time. DPPC-surfactant treatment of quartz delayed most DNA damage expression to 5 and 7 d. Untreated kaolin expressed weaker activity for DNA damage, significant at the highest concentration through 5 d, and at the higher concentrations on d 7. Surfactant treatment delayed most kaolin activity for DNA damage to 7 d after challenge. JF - Journal of toxicology and environmental health. Part A AU - Gao, N AU - Keane, M J AU - Ong, T AU - Wallace, W E AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2000/06/09/ PY - 2000 DA - 2000 Jun 09 SP - 153 EP - 167 VL - 60 IS - 3 SN - 1528-7394, 1528-7394 KW - Antidiarrheals KW - 0 KW - Dust KW - Pulmonary Surfactants KW - Quartz KW - 14808-60-7 KW - Kaolin KW - 24H4NWX5CO KW - 1,2-Dipalmitoylphosphatidylcholine KW - 2644-64-6 KW - Index Medicus KW - Rats KW - Pulmonary Alveoli -- pathology KW - Animals KW - 1,2-Dipalmitoylphosphatidylcholine -- pharmacology KW - Particle Size KW - Inhalation Exposure KW - Pulmonary Alveoli -- drug effects KW - Cell Culture Techniques KW - Time Factors KW - Male KW - Kaolin -- toxicity KW - DNA Damage KW - Antidiarrheals -- toxicity KW - Pulmonary Surfactants -- pharmacology KW - Macrophages, Alveolar -- drug effects KW - Macrophages, Alveolar -- physiology KW - Quartz -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71258710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Effects+of+simulated+pulmonary+surfactant+on+the+cytotoxicity+and+DNA-damaging+activity+of+respirable+quartz+and+kaolin.&rft.au=Gao%2C+N%3BKeane%2C+M+J%3BOng%2C+T%3BWallace%2C+W+E&rft.aulast=Gao&rft.aufirst=N&rft.date=2000-06-09&rft.volume=60&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-18 N1 - Date created - 2000-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of type I IFNs in the in vitro attenuation of live, temperature-sensitive vaccine strains of human respiratory syncytial virus. AN - 71204877; 10860892 AB - The contributions of type I interferons (IFNs) to the in vitro attenuation of three temperature-sensitive (Ts) subgroup A and one subgroup B deletion mutant RSV strains were evaluated. The ability of these vaccine viruses to induce IFNs at their permissive and restrictive temperatures and their sensitivity to the antiviral effects of exogenous I IFNs were tested in human lung epithelial A549 cells. Our results show that the highly attenuated and immunogenic subgroup A vaccine strain Ts1C produced higher levels of IFN-beta than its parent RSS-2 or two related strains, Ts1A and Ts1B, at their permissive temperature. Growth of RSV-infected A549 cultures at restrictive temperatures or prior UV inactivation of the virus abolished the observed induction of IFN-beta, suggesting a strict requirement of viral replication for cellular IFN induction. The enhanced induction of IFN-beta by the highly immunogenic Ts1C at permissive temperature may be an advantageous characteristic of a live intranasal vaccine candidate. The subgroup B strain RSV B1 and its mutant cp-52 (with SH and G gene deletions) both induced similar but low levels of IFN-beta. Hence the observed overattenuation of cp-52 in human infants is probably not due to enhanced IFN induction during its replication in the host. The ability of cp-52, which does not express the SH and G proteins, to induce IFN-beta levels similar to those of its parent strain suggests that these viral proteins may not have a role in the induction of IFN-beta in the host. In addition, both subgroup A and B mutants and their respective parent strains were similarly resistant to the antiviral effects of exogenous IFN-alpha or -beta. Therefore, increased sensitivity of the mutants to IFNs does not seem to contribute to their attenuation. Copyright 2000 Academic Press. JF - Virology AU - Loveys, D A AU - Kulkarni, S AU - Atreya, P L AD - Laboratory of Pediatric and Respiratory Viral Diseases, DVP/CBER, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000/06/05/ PY - 2000 DA - 2000 Jun 05 SP - 390 EP - 400 VL - 271 IS - 2 SN - 0042-6822, 0042-6822 KW - Interferon-alpha KW - 0 KW - RNA, Messenger KW - Vaccines, Attenuated KW - Viral Vaccines KW - Interferon-beta KW - 77238-31-4 KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Animals KW - Tumor Cells, Cultured KW - Interferon-alpha -- biosynthesis KW - Humans KW - Cercopithecus aethiops KW - Temperature KW - Viral Vaccines -- immunology KW - Cell Line KW - Mutagenesis KW - Respiratory Syncytial Virus, Human -- growth & development KW - Respiratory Syncytial Virus, Human -- immunology KW - Interferon-beta -- biosynthesis KW - Interferon-beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71204877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Role+of+type+I+IFNs+in+the+in+vitro+attenuation+of+live%2C+temperature-sensitive+vaccine+strains+of+human+respiratory+syncytial+virus.&rft.au=Loveys%2C+D+A%3BKulkarni%2C+S%3BAtreya%2C+P+L&rft.aulast=Loveys&rft.aufirst=D&rft.date=2000-06-05&rft.volume=271&rft.issue=2&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-02 N1 - Date created - 2000-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protective Immunity to Bordetella pertussis Requires Both B Cells and CD4 super(+) T Cells for Key Functions Other than Specific Antibody Production AN - 17550201; 4731823 AB - To investigate the fundamental nature of protective immunity to Bordetella pertussis, we studied intranasal immunization of adult mice with formalin-fixed B. pertussis (FFBP), followed by aerosol B. pertussis challenge. Mice given two doses of FFBP intranasally completely cleared a subsequent pertussis aerosol challenge from tracheae and lungs (defined as protection), but there was no correlation between levels of specific antibody and clearance of bacteria. Further, transfer of immune serum before aerosol challenge had minimal effects on bacterial burdens. However, pertussis-specific T cells producing interferon gamma but not interleukin 4 or interleukin 10 were detected in draining lymph nodes of FFBP-immunized mice. Significantly, repeated immunization of B cell knockout (BKO) mice resulted in partial protection, and complete protection was reconstituted by transfer of pertussis-immune B cells; reconstituted BKO mice had little if any detectable antipertussis antibodies. Immunization of mice lacking all T cells or lacking CD4 super(+) T cells did not lead to protection; in contrast, CD8 super(-) mice were protected. Mice depleted of CD4 super(+) T cells after immunization but before aerosol challenge, which thus had normal amounts of specific antibodies, were not optimally protected. Taken together, these data indicate that protective immunity to pertussis is dependent on both CD4 super(+) T cells and B cells, and both cell types provide significant functions other than specific antibody production. JF - Journal of Experimental Medicine AU - Leef, M AU - Elkins, K L AU - Barbic, J AU - Shahin, R D AD - Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA, elkins@cber.fda.gov Y1 - 2000/06/05/ PY - 2000 DA - 2000 Jun 05 SP - 1841 EP - 1852 VL - 191 IS - 11 SN - 0022-1007, 0022-1007 KW - mice KW - immunology KW - Bordetella pertussis KW - CD4 antigen KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lymphocytes B KW - Lymphocytes T KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms KW - F 06749:Function KW - F 06756:Function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17550201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Protective+Immunity+to+Bordetella+pertussis+Requires+Both+B+Cells+and+CD4+super%28%2B%29+T+Cells+for+Key+Functions+Other+than+Specific+Antibody+Production&rft.au=Leef%2C+M%3BElkins%2C+K+L%3BBarbic%2C+J%3BShahin%2C+R+D&rft.aulast=Leef&rft.aufirst=M&rft.date=2000-06-05&rft.volume=191&rft.issue=11&rft.spage=1841&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bordetella pertussis; Lymphocytes T; Lymphocytes B ER - TY - JOUR T1 - Intracellular parasitism by the human granulocytic ehrliochisis bacterium through the P-selectin ligand, PSGL-1 AN - 17543780; 4719916 AB - Human granolocytic ehrlichiosis (HGE) is a febrile tick-borne illness caused by a recently discovered intracellular bacterium remarkable for its tropism for professionally phagocytic neutrophils. Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1. Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha -(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE. Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1. Selectin mimicry is likely central to the organism's unique ability to target and infect neutrophils. JF - Science (Washington) AU - Herron, MJ AU - Nelson, C M AU - Larson, J AU - Snapp, K R AU - Kansas, G S AU - Goodman, J L AD - Div. Infect. Dis., Dep. Med., Univ. Minnesota Sch. Med., Minneapolis, MN 55455, USA, goodmanj@cber.fda.gov Y1 - 2000/06/02/ PY - 2000 DA - 2000 Jun 02 SP - 1653 EP - 1656 PB - American Association for the Advancement of Science VL - 288 IS - 5471 SN - 0036-8075, 0036-8075 KW - immunology KW - Ehrlichia KW - P-Selectin KW - P-selectin KW - PSGL-1 protein KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Leukocytes (neutrophilic) KW - Ehrlichiosis KW - Parasitism KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17543780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Intracellular+parasitism+by+the+human+granulocytic+ehrliochisis+bacterium+through+the+P-selectin+ligand%2C+PSGL-1&rft.au=Herron%2C+MJ%3BNelson%2C+C+M%3BLarson%2C+J%3BSnapp%2C+K+R%3BKansas%2C+G+S%3BGoodman%2C+J+L&rft.aulast=Herron&rft.aufirst=MJ&rft.date=2000-06-02&rft.volume=288&rft.issue=5471&rft.spage=1653&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.288.5471.1653 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ehrlichia; Parasitism; Leukocytes (neutrophilic); Ehrlichiosis DO - http://dx.doi.org/10.1126/science.288.5471.1653 ER - TY - JOUR T1 - Risk Assessment for Quantitative Responses Using a Mixture Model AN - 920787635; 15992368 AB - Summary. A problem that frequently occurs in biological experiments with laboratory animals is that some subjects are less susceptible to the treatment than others. A mixture model has traditionally been proposed to describe the distribution of responses in treatment groups for such experiments. Using a mixture dose-response model, we derive an upper confidence limit on additional risk, defined as the excess risk over the background risk due to an added dose. Our focus will be on experiments with continuous responses for which risk is the probability of an adverse effect defined as an event that is extremely rare in controls. The asymptotic distribution of the likelihood ratio statistic is used to obtain the upper confidence limit on additional risk. The method can also be used to derive a benchmark dose corresponding to a specified level of increased risk. The EM algorithm is utilized to find the maximum likelihood estimates of model parameters and an extension of the algorithm is proposed to derive the estimates when the model is subject to a specified level of added risk. An example is used to demonstrate the results, and it is shown that by using the mixture model a more accurate measure of added risk is obtained. JF - Biometrics AU - Razzaghi, Mehdi AU - Kodell, Ralph L AD - Department of Mathematics, Bloomsburg University, Bloomsburg, Pennsylvania 17815, U.S.A., and National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, U.S.A. email:razzaghiloomu.edu Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 519 EP - 527 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 56 IS - 2 SN - 0006-341X, 0006-341X KW - Risk Abstracts KW - Dose-response effects KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920787635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Risk+Assessment+for+Quantitative+Responses+Using+a+Mixture+Model&rft.au=Razzaghi%2C+Mehdi%3BKodell%2C+Ralph+L&rft.aulast=Razzaghi&rft.aufirst=Mehdi&rft.date=2000-06-01&rft.volume=56&rft.issue=2&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.0006-341X.2000.00519.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Dose-response effects DO - http://dx.doi.org/10.1111/j.0006-341X.2000.00519.x ER - TY - JOUR T1 - Anisotropy of ultrasonic backscatter and attenuation from human calcaneus: implications for relative roles of absorption and scattering in determining attenuation. AN - 85345591; pmid-10875391 AB - Although bone sonometry has been demonstrated to be useful in the diagnosis of osteoporosis, much remains to be learned about the processes governing the interactions between ultrasound and bone. In order to investigate these processes, ultrasonic attenuation and backscatter in two orientations were measured in 43 human calcaneal specimens in vitro at 500 kHz. In the mediolateral (ML) orientation, the ultrasound propagation direction is approximately perpendicular to the trabecular axes. In the anteroposterior (AP) orientation, a wide range of angles between the ultrasound propagation direction and trabecular axes is encountered. Average attenuation slope was 18% greater while average backscatter coefficient was 50% lower in the AP orientation compared with the ML orientation. Backscatter coefficient in both orientations approximately conformed to a cubic dependence on frequency, consistent with a previously reported model. These results support the idea that absorption is a greater component of attenuation than scattering in human calcaneal trabecular bone. JF - The Journal of the Acoustical Society of America AU - Wear, K A AD - U. S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, Maryland 20852, USA. kaw@cdrh.fda.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 3474 EP - 3479 VL - 107 IS - 6 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Anisotropy KW - Humans KW - Calcaneus -- ultrasonography KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85345591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Anisotropy+of+ultrasonic+backscatter+and+attenuation+from+human+calcaneus%3A+implications+for+relative+roles+of+absorption+and+scattering+in+determining+attenuation.&rft.au=Wear%2C+K+A&rft.aulast=Wear&rft.aufirst=K&rft.date=2000-06-01&rft.volume=107&rft.issue=6&rft.spage=3474&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Vibrio gastroenteritis in the US Gulf of Mexico region: the role of raw oysters. AN - 72242275; 10982073 AB - We examined clinical and epidemiological features of 575 laboratory-confirmed cases of vibrio gastroenteritis in Alabama, Florida, Louisiana, and Texas from 1988 to 1997 (the US Gulf of Mexico Regional Vibrio Surveillance System). Illnesses occurred year round, with peaks in spring and autumn. Illnesses lasted a median of 7 days and included fever in half of patients and bloody stools in 25% of patients with relevant information. Seventy-two percent of patients reported no underlying illnesses. In the week before onset, 236 (53%) of 445 patients for whom data were available ate raw oysters, generally at a restaurant or bar. Educational efforts should address the risk of vibrio gastroenteritis for raw oyster consumers, including healthy individuals. Further studies should examine environmental conditions affecting vibrio counts on seafood and processing technologies to enhance the safety of raw oysters. JF - Epidemiology and infection AU - Altekruse, S F AU - Bishop, R D AU - Baldy, L M AU - Thompson, S G AU - Wilson, S A AU - Ray, B J AU - Griffin, P M AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 489 EP - 495 VL - 124 IS - 3 SN - 0950-2688, 0950-2688 KW - Index Medicus KW - Animals KW - Education KW - Southeastern United States -- epidemiology KW - Risk Factors KW - Humans KW - Seasons KW - Adult KW - Male KW - Female KW - Vibrio Infections -- etiology KW - Ostreidae -- virology KW - Shellfish -- virology KW - Gastroenteritis -- virology KW - Gastroenteritis -- pathology KW - Gastroenteritis -- etiology KW - Vibrio Infections -- pathology KW - Food Contamination KW - Vibrio Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72242275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+infection&rft.atitle=Vibrio+gastroenteritis+in+the+US+Gulf+of+Mexico+region%3A+the+role+of+raw+oysters.&rft.au=Altekruse%2C+S+F%3BBishop%2C+R+D%3BBaldy%2C+L+M%3BThompson%2C+S+G%3BWilson%2C+S+A%3BRay%2C+B+J%3BGriffin%2C+P+M&rft.aulast=Altekruse&rft.aufirst=S&rft.date=2000-06-01&rft.volume=124&rft.issue=3&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+infection&rft.issn=09502688&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-20 N1 - Date created - 2000-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Does caloric restriction induce hormesis? AN - 72211424; 10962498 AB - The question of whether caloric restriction (CR) is hormetic is addressed in terms of two common definitions of the term. In terms of the older definition, i.e., a growth-stimulatory effect when lower doses of a compound which resulted in growth inhibition at higher doses, CR is better characterized as a co-hormetic (i.e., a paradigm which at relatively "low doses," in combination with some stimulus, will evince increased growth (proliferation) and at higher "doses" will inhibit this increased proliferation) rather than a hormetic agent. Mechanisms such as cellular selection of cellular subpopulations, increases in receptor efficiency, and preservation of cellular proliferative potential can interact with agents and produce increased growth as long as the CR is not too severe. In terms of a broader definition, i.e., nonmonotonic dose-response behavior of a compound for any adverse response, CR appears to be hormetic, both as a result of body weight (BW) loss and other potential mechanisms. The impact of changes in BW, or frank CR, can be considered a component of every test for hormesis, and is thus capable for interaction with any other agent. The changes that BW loss (or CR) induce are so profound that any aspect of an agent's action - metabolism, pharmacokinetics, pharmacodynamics - can modulate the response of an organism to an agent. Similarly, other effects of a chemical that induce BW loss, e.g., physical activity or temperature dysregulation, can also induce dose-response curves that appear hormetic. The interaction of the hormetic agents of BW loss and CR can influence agent tests. Controlling these factors may make it possible to dissect the key components of a hormetic response. In addition, the effects of CR or BW loss appear to extrapolate well across species [Colman R, Kemnitz JW. Aging experiments using nonhuman primates. In: Yu BP (Ed), Methods in Aging Research. CRC Press, Boca Raton, FL, 1999, pp. 249-267]. Thus there is some reason to believe that these hormetic factors may be important for humans, and may already be a factor for tests of potentially adverse agents already conducted in humans. JF - Human & experimental toxicology AU - Turturro, A AU - Hass, B S AU - Hart, R W AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research (NCTR), Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 320 EP - 329 VL - 19 IS - 6 SN - 0960-3271, 0960-3271 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Animals KW - Survival Rate KW - Hazardous Substances -- adverse effects KW - Humans KW - Body Weight -- drug effects KW - Body Weight -- physiology KW - Poisoning -- mortality KW - Male KW - Adaptation, Physiological -- drug effects KW - Adaptation, Physiological -- physiology KW - Dose-Response Relationship, Drug KW - Energy Intake -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72211424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Does+caloric+restriction+induce+hormesis%3F&rft.au=Turturro%2C+A%3BHass%2C+B+S%3BHart%2C+R+W&rft.aulast=Turturro&rft.aufirst=A&rft.date=2000-06-01&rft.volume=19&rft.issue=6&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-25 N1 - Date created - 2000-09-25 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Four earplugs in search of a rating system. AN - 71249381; 10890730 AB - The performance of four insert earplugs was evaluated by determining the Noise Reduction Rating (NRR) and the Subject-Fit Noise Reduction Rating [NRR(SF)]. The NRR and NRR(SF) were calculated from real-ear attenuation at threshold (REAT) data collected using the experimenter-fit protocol described in the now-rescinded ANSI S3.19-1974 (American National Standards Institute, 1974) and the subject-fit protocol of the recently revised ANSI S12.6-1997 (American National Standards Institute, 1997) standards for REAT measurement. A comparison of the experimenter-fit and subject-fit REAT performance was conducted using four pools of subjects, one pool per protector. Each device was tested with at least 20 subjects, the minimum size necessary to estimate the NRR(SF) for an earplug. The REAT was measured with third-octave narrowband noise stimuli for center frequencies at 0.125, 0.25,0.5, 1, 2, 3.15, 4, 6.3, and 8 kHz. The REAT means and standard deviations were compared with the manufacturer data. This study showed that the NRR(SF) is typically lower than the NRR and that the NRR(SF) is not well-predicted by the NRR derating schemes recommended by the National Institute for Occupational Safety and Health and required by the Occupational Safety and Health Administration. The difference between the present NRR on hearing protector labels and the NRR(SF) is sufficiently large and unpredictable enough to render the application of derating schemes meaningless even though these schemes attempt to account for the difference between the laboratory and real-world outcomes. The only way to provide a protector noise rating that is predictive of a real-world outcome is to retest the protector according to the subject-fit method of ANSI S12.6-1997 (American National Standards Institute, 1997). JF - Ear and hearing AU - Franks, J R AU - Murphy, W J AU - Johnson, J L AU - Harris, D A AD - Hearing Loss Prevention Section, Engineering and Physical Agents Branch Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 218 EP - 226 VL - 21 IS - 3 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - Auditory Threshold -- physiology KW - Equipment Design KW - Prosthesis Fitting KW - Humans KW - Male KW - Female KW - Occupational Diseases -- prevention & control KW - Hearing Loss, Noise-Induced -- prevention & control KW - Ear Protective Devices -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71249381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Four+earplugs+in+search+of+a+rating+system.&rft.au=Franks%2C+J+R%3BMurphy%2C+W+J%3BJohnson%2C+J+L%3BHarris%2C+D+A&rft.aulast=Franks&rft.aufirst=J&rft.date=2000-06-01&rft.volume=21&rft.issue=3&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monitoring change in behavioral health care. The role of the Center for Mental Health Services. AN - 71245860; 10909109 AB - One of the strategic goals of the Substance Abuse and Mental Health Services Administration (SAMHSA) is to improve managed care outcomes. This report from the Office of Managed Care, Center for Mental Health Services, summarizes the results of six SAMHSA projects. The studies discussed were selected because they have yielded substantive findings. One nationwide evaluation showed increasing complexity in contracts between state Medicaid agencies and managed care organizations, as states move toward greater use of managed mental health and substance abuse program arrangements and greater inclusion of persons with disabilities. A report from SAMHSA's Managed Care Tracking System indicates that, contrary to predictions, most public-sector mental health and substance abuse programs are managed by public-sector agencies or public or private partnerships rather than by private managed care organizations. Also, an analysis of pre-managed care Medicaid data on mental health and substance abuse services in 10 states is serving as a baseline to assess the effects of managed care on Medicaid mental health and substance abuse program use and costs. JF - The Psychiatric clinics of North America AU - Teich, J L AD - Office of Managed Care, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, Maryland, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 297 EP - 308, vi-vii VL - 23 IS - 2 SN - 0193-953X, 0193-953X KW - Index Medicus KW - United States KW - Contract Services KW - Humans KW - Medicaid KW - United States Substance Abuse and Mental Health Services Administration KW - Mental Disorders -- rehabilitation KW - Managed Care Programs KW - Behavior Therapy KW - Outcome Assessment (Health Care) KW - Substance-Related Disorders -- rehabilitation KW - Quality Assurance, Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71245860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Monitoring+change+in+behavioral+health+care.+The+role+of+the+Center+for+Mental+Health+Services.&rft.au=Teich%2C+J+L&rft.aulast=Teich&rft.aufirst=J&rft.date=2000-06-01&rft.volume=23&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-05 N1 - Date created - 2000-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Restricted and shared patterns of TCR beta-chain gene expression in silicone breast implant capsules and remote sites of tissue inflammation. AN - 71228542; 10882054 AB - Silicone breast implants (SBI) induce formation of a periprosthetic, often inflammatory, fibrovascular neo-tissue called a capsule. Histopathology of explanted capsules varies from densely fibrotic, acellular specimens to those showing intense inflammation with activated macrophages, multinucleated giant cells, and lymphocytic infiltrates. It has been proposed that capsule-infiltrating lymphocytes comprise a secondary, bystander component of an otherwise benign foreign body response in women with SBIs. In symptomatic women with SBIs, however, the relationship of capsular inflammation to inflammation in other remote tissues remains unclear. In the present study, we utilized a combination of TCR beta-chain CDR3 spectratyping and DNA sequence analysis to assess the clonal heterogeneity of T cells infiltrating SBI capsules and remote, inflammatory tissues. TCR CDR3 fragment analysis of 22 distinct beta variable (BV) gene families revealed heterogeneous patterns of T cell infiltration in patients' capsules. In some cases, however, TCR BV transcripts exhibiting restricted clonality with shared CDR3 lengths were detected in left and right SBI capsules and other inflammatory tissues. DNA sequence analysis of shared, size-restricted CDR3 fragments confirmed that certain TCR BV transcripts isolated from left and right SBI capsules and multiple, extracapsular tissues had identical amino acid sequences within the CDR3 antigen binding domain. These data suggest that shared, antigen-driven T cell responses may contribute to chronic inflammation in SBI capsules as well as systemic sites of tissue injury. JF - Journal of autoimmunity AU - O'Hanlon, T P AU - Lawless, O J AU - Katzin, W E AU - Feng, L J AU - Miller, F W AD - Laboratory of Molecular and Developmental Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 283 EP - 293 VL - 14 IS - 4 SN - 0896-8411, 0896-8411 KW - Complementarity Determining Regions KW - 0 KW - Immunoglobulin Variable Region KW - Receptors, Antigen, T-Cell, alpha-beta KW - Silicone Gels KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Clone Cells KW - Immunoglobulin Variable Region -- genetics KW - Humans KW - Gene Expression KW - Amino Acid Sequence KW - T-Lymphocytes -- pathology KW - Sequence Analysis, DNA KW - Adult KW - DNA -- genetics KW - Breast -- pathology KW - Middle Aged KW - Immunohistochemistry KW - T-Lymphocytes -- immunology KW - Female KW - Silicone Gels -- adverse effects KW - Genes, T-Cell Receptor beta -- genetics KW - Mastitis -- immunology KW - Mastitis -- metabolism KW - Receptors, Antigen, T-Cell, alpha-beta -- genetics KW - Receptors, Antigen, T-Cell, alpha-beta -- biosynthesis KW - Mastitis -- genetics KW - Breast Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71228542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+autoimmunity&rft.atitle=Restricted+and+shared+patterns+of+TCR+beta-chain+gene+expression+in+silicone+breast+implant+capsules+and+remote+sites+of+tissue+inflammation.&rft.au=O%27Hanlon%2C+T+P%3BLawless%2C+O+J%3BKatzin%2C+W+E%3BFeng%2C+L+J%3BMiller%2C+F+W&rft.aulast=O%27Hanlon&rft.aufirst=T&rft.date=2000-06-01&rft.volume=14&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+autoimmunity&rft.issn=08968411&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-17 N1 - Date created - 2000-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Natural rubber latex: glove use, sensitization, and airborne and latent dust concentrations at a Denver hospital. AN - 71221106; 10874654 AB - Exposure to natural rubber latex may cause immediate hypersensitivity reactions. Published latex sensitization prevalence rates range from 2.9% to 22% among health care workers, and from 0.12% to about 20% of occupationally unexposed populations. In this study, self-administered questionnaires addressed job and personal characteristics, glove use, and symptoms in two groups of hospital workers: those who regularly used latex gloves and those who did not. Serum was tested for latex-specific immunoglobulin E. Air, surface, and air-filter dust samples for natural rubber latex were collected. The prevalence of latex sensitization was 6.3% in the non-users and 6.1% in the latex glove users (P = 0.9); 81.3% of sensitized workers were atopic compared with 59.5% of non-sensitized workers (P < 0.05). Reporting of work-related hand dermatitis was more common in the latex glove users (23.4%) than in the non-users (4.9%), as were rhino-conjunctivitis (16.3% and 7.9%, respectively, [P < 0.01]), and hand urticaria (9.9% and 2.1%, respectively, [P < 0.01]). There was no significant difference in work-related symptoms between the sensitized and non-sensitized workers. Environmental concentrations of latex were higher in the work areas of the non-sensitized workers, but higher in the clinical than in the non-clinical areas. Occupational latex glove use was not a risk factor for sensitization. JF - Journal of occupational and environmental medicine AU - Page, E H AU - Esswein, E J AU - Petersen, M R AU - Lewis, D M AU - Bledsoe, T A AD - Epidemic Intelligence Service, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA. edp7@cdc.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 613 EP - 620 VL - 42 IS - 6 SN - 1076-2752, 1076-2752 KW - Dust KW - 0 KW - Immunoglobulin G KW - Index Medicus KW - Odds Ratio KW - Dust -- analysis KW - Humans KW - Seroepidemiologic Studies KW - Hospitals, Urban KW - Environmental Monitoring -- statistics & numerical data KW - Immunoglobulin G -- blood KW - Logistic Models KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Sampling Studies KW - Case-Control Studies KW - Gloves, Protective -- adverse effects KW - Middle Aged KW - Epidemiological Monitoring KW - Dust -- adverse effects KW - Colorado -- epidemiology KW - Statistics, Nonparametric KW - Male KW - Female KW - Latex Hypersensitivity -- diagnosis KW - Hypersensitivity, Immediate -- etiology KW - Occupational Exposure -- statistics & numerical data KW - Latex Hypersensitivity -- epidemiology KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Health Personnel -- statistics & numerical data KW - Occupational Exposure -- adverse effects KW - Latex Hypersensitivity -- immunology KW - Hypersensitivity, Immediate -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71221106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Natural+rubber+latex%3A+glove+use%2C+sensitization%2C+and+airborne+and+latent+dust+concentrations+at+a+Denver+hospital.&rft.au=Page%2C+E+H%3BEsswein%2C+E+J%3BPetersen%2C+M+R%3BLewis%2C+D+M%3BBledsoe%2C+T+A&rft.aulast=Page&rft.aufirst=E&rft.date=2000-06-01&rft.volume=42&rft.issue=6&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-01 N1 - Date created - 2000-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of ozone treatment on airway reactivity and epithelium-derived relaxing factor in guinea pigs. AN - 71215318; 10869370 AB - Ozone (O(3)) is toxic to respiratory epithelium and causes airway inflammation and hyperreactivity. To evaluate the role of the epithelium in the development of hyperreactivity, we examined in guinea pigs the effects of inhaled O(3) (3 ppm for 1 h; 0-24 h after exposure) on 1) reactivity to inhaled methacholine (MCh), 2) reactivity of the isolated, perfused trachea (IPT) to MCh, 3) epithelium-derived relaxing factor (EpDRF)-mediated relaxations of IPT induced by mucosal hyperosmolar solutions, 4) neurogenic contraction and relaxation responses, 5) transepithelial potential difference, and 6) microscopic analysis of nitrotyrosine immunofluorescence, substance P fiber density, and tracheal morphology. At 0 h, O(3) caused hyperreactivity to inhaled MCh and mucosally but not serosally applied MCh in IPT (only in the presence of the epithelium) and a decrease in transepithelial potential difference. Inhibition of EpDRF-induced relaxation responses occurred at 2 h. All of these changes returned to control by 12 to 18 h. O(3) had no effect on neurogenic responses. Nitrotyrosine immunofluorescence appeared in the trachea at 0 h in detached epithelial cell ghosts and in intrapulmonary airways by 6 h. Substance P fiber density was elevated in smooth muscle at 0 and 18 h but not in epithelium or lamina propria of intrapulmonary and extrapulmonary bronchi. Loss of cilia and mucosubstances in the mucosa occurred at 0 h; the epithelium became markedly attenuated over 12 to 24 h. A reversible increase in epithelial permeability and a decrease in EpDRF production may contribute to O(3)-induced hyperreactivity to MCh. JF - The Journal of pharmacology and experimental therapeutics AU - Fedan, J S AU - Millecchia, L L AU - Johnston, R A AU - Rengasamy, A AU - Hubbs, A AU - Dey, R D AU - Yuan, L X AU - Watson, D AU - Goldsmith, W T AU - Reynolds, J S AU - Orsini, L AU - Dortch-Carnes, J AU - Cutler, D AU - Frazer, D G AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. jsf2@cdc.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 724 EP - 734 VL - 293 IS - 3 SN - 0022-3565, 0022-3565 KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Nitric Oxide KW - 31C4KY9ESH KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Methacholine Chloride -- pharmacology KW - Animals KW - Perfusion KW - Guinea Pigs KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Epithelium -- physiology KW - Male KW - Trachea -- pathology KW - Nitric Oxide -- biosynthesis KW - Trachea -- drug effects KW - Trachea -- physiology KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71215318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Effect+of+ozone+treatment+on+airway+reactivity+and+epithelium-derived+relaxing+factor+in+guinea+pigs.&rft.au=Fedan%2C+J+S%3BMillecchia%2C+L+L%3BJohnston%2C+R+A%3BRengasamy%2C+A%3BHubbs%2C+A%3BDey%2C+R+D%3BYuan%2C+L+X%3BWatson%2C+D%3BGoldsmith%2C+W+T%3BReynolds%2C+J+S%3BOrsini%2C+L%3BDortch-Carnes%2C+J%3BCutler%2C+D%3BFrazer%2C+D+G&rft.aulast=Fedan&rft.aufirst=J&rft.date=2000-06-01&rft.volume=293&rft.issue=3&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-14 N1 - Date created - 2000-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Summary of a workshop on in vivo efficacy of transfused platelet components and platelet substitutes. AN - 71213549; 10864998 JF - Transfusion AU - Vostal, J G AU - Reid, T J AU - Mondoro, T H Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 742 EP - 750 VL - 40 IS - 6 KW - Blood Substitutes KW - 0 KW - Index Medicus KW - Animals KW - Platelet Function Tests KW - Thrombocytopenia -- therapy KW - Freeze Drying KW - Humans KW - Bone Marrow Diseases -- therapy KW - Disease Models, Animal KW - Rabbits KW - Thrombocytopenia -- blood KW - Cryopreservation KW - Evaluation Studies as Topic KW - Radiation Injuries, Experimental -- therapy KW - Bleeding Time KW - Hemostasis KW - Radiation Injuries, Experimental -- blood KW - Bone Marrow Diseases -- blood KW - Blood Preservation KW - Platelet Transfusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71213549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Transfusion&rft.atitle=Summary+of+a+workshop+on+in+vivo+efficacy+of+transfused+platelet+components+and+platelet+substitutes.&rft.au=Vostal%2C+J+G%3BReid%2C+T+J%3BMondoro%2C+T+H&rft.aulast=Vostal&rft.aufirst=J&rft.date=2000-06-01&rft.volume=40&rft.issue=6&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-12 N1 - Date created - 2000-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acquisition of microbiological data to enhance food safety. AN - 71204797; 10852582 AB - The routine acquisition and archiving of microbiological data is undertaken for two reasons. The first is the development of historical microbiological profiles of foods, ingredients, or processes in order to determine or verify that microorganisms of concern are being controlled to the level desired. The second reason is data concerning the pathogenicity or virulence of foodborne pathogens and their behavior in foods in order to develop strategies and criteria for assuring microbiological safety. Both types of microbiological data are essential to effective food safety programs. A firm understanding of the uses and limitations of both is essential to correct acquisition, interpretation, and use of such data. JF - Journal of food protection AU - Buchanan, R L AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA. rbuchana@banagate.fda.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 832 EP - 838 VL - 63 IS - 6 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Microbiological Techniques KW - Food Preservation KW - Databases, Factual -- economics KW - Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71204797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Acquisition+of+microbiological+data+to+enhance+food+safety.&rft.au=Buchanan%2C+R+L&rft.aulast=Buchanan&rft.aufirst=R&rft.date=2000-06-01&rft.volume=63&rft.issue=6&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-10 N1 - Date created - 2000-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of microbial data for hazard analysis and critical control point verification--Food and Drug Administration perspective. AN - 71183133; 10852577 AB - This paper examines the role that the microbiologist and microbiological testing play in implementing hazard analysis and critical control point (HACCP) programs. HACCP offers a more comprehensive and science-based alternative for controlling food safety hazards compared with traditional sanitation programs based upon good manufacturing practices. Controlling hazards under an HACCP program requires a systematic assemblage of reliable data relating to the occurrence, elimination, prevention, and reduction of hazards. These data need to be developed in a transparent environment that will ensure that the best scientific methodologies have been employed in developing the needed data. The two mechanisms used in HACCP to assess the adequacy of the database are validation studies and the verification assessments. Microbiological testing is an important mechanism for collecting data used in developing and implementing an HACCP plan. Microbial sample data can help establish standard operating procedures (SOPs) for sanitation, assess the likelihood of the occurrence of hazards, establish critical limits, and assess the validity of the HACCP plan. The use of a performance standard to assess whether microbiological hazards have been reduced to an acceptable level creates an especially important use for microbial analysis. Microbial testing is also useful in implementing an HACCP plan by helping to monitor the effectiveness of sanitation SOPs, the compliance of incoming ingredients with safety criteria, the safety of product being held for corrective action, and the safety of the finished product. The verification audits demonstrate that all control measures have been applied as designed in the HACCP plan. Although auditing HACCP records is the primary means of verification, microbial sampling can play an important role as well. JF - Journal of food protection AU - Kvenberg, J E AU - Schwalm, D J AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA. kvenber@bangate.fda.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 810 EP - 814 VL - 63 IS - 6 SN - 0362-028X, 0362-028X KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Management Audit KW - Proportional Hazards Models KW - Food Contamination -- prevention & control KW - Food Microbiology KW - Food-Processing Industry -- standards KW - Food Inspection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71183133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Use+of+microbial+data+for+hazard+analysis+and+critical+control+point+verification--Food+and+Drug+Administration+perspective.&rft.au=Kvenberg%2C+J+E%3BSchwalm%2C+D+J&rft.aulast=Kvenberg&rft.aufirst=J&rft.date=2000-06-01&rft.volume=63&rft.issue=6&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-10 N1 - Date created - 2000-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Results of a nationwide survey of chest radiography: comparison with results of a previous study. AN - 71152054; 10831717 AB - To provide public health information by means of measurement of the radiation exposures that patients undergoing chest radiography would receive and to compare the results with those of a similar previous survey. Surveyed facilities were randomly selected from each state. Patient exposure was evaluated along with film processing, half-value layer, and image quality. Additional information obtained concerned type of equipment, facility work load, radiographic technique, screen-film system, and grid type. Mean entrance air kerma in all facilities was 141 microGy (16.1 mR). Mean kilovoltage in all facilities was 101 kV. In 1994, 140 (90%) of 156 hospitals (vs 71% in 1984) and 92 (58%; nearly double the percentage in 1984) of 159 nonhospital sites were using grids. Scoring with the imaging test tool resulted in a mean spatial resolution of 2.3 cycles per millimeter, and a mean low-contrast sensitivity of about 3%. Two hundred fifty-three (80%) of 315 facilities surveyed were processing film at minimum acceptable performance levels. Mean entrance air kerma for all facilities did not substantially change. Although increased grid usage would lead to the expectation of higher measured exposures, this was offset by an increase in the use of faster screen-film combinations. JF - Radiology AU - Kaczmarek, R V AU - Conway, B J AU - Slayton, R O AU - Suleiman, O H AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20850, USA. rvk@cdrh.fda.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 891 EP - 896 VL - 215 IS - 3 SN - 0033-8419, 0033-8419 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Phantoms, Imaging KW - Radiation Dosage KW - Random Allocation KW - Humans KW - X-Ray Intensifying Screens KW - Radiography, Thoracic -- instrumentation KW - Radiography, Thoracic -- trends KW - Radiography, Thoracic -- utilization KW - Health Surveys KW - Radiography, Thoracic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71152054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Results+of+a+nationwide+survey+of+chest+radiography%3A+comparison+with+results+of+a+previous+study.&rft.au=Kaczmarek%2C+R+V%3BConway%2C+B+J%3BSlayton%2C+R+O%3BSuleiman%2C+O+H&rft.aulast=Kaczmarek&rft.aufirst=R&rft.date=2000-06-01&rft.volume=215&rft.issue=3&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-21 N1 - Date created - 2000-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of genistein exposure on sexually dimorphic behaviors in rats. AN - 71149484; 10828262 AB - The phytoestrogen genistein, the principal isoflavone in soybeans, has adverse effects on animal reproduction. As adult physiology and behavior are sensitive to perturbation by developmental estrogens, exposure to genistein during development may produce behavioral alterations as well. Pregnant rats were fed soy-free diets containing 0, 25, 250, or 1250 ppm genistein (approximately 0, 2, 20, or 100 mg/kg/day) beginning on gestational day 7, and offspring continued on these diets through postnatal day (PND) 77. Male and female offspring were assessed for levels of sexually dimorphic behaviors: open field activity, play behavior, running wheel activity, and consumption of saccharin- and sodium chloride-flavored solutions. Consumption of the salt solution was affected by genistein, with animals in the 1250-ppm group drinking significantly more than controls; consumption of plain water was unaffected. Genistein treatment also significantly affected play behavior; although no treated group was significantly different from controls, and the effect was not sexually dimorphic. Running wheel activity and saccharin solution consumption showed significant sex differences, but no effects of genistein treatment. Gestational duration, total and live pups per litter, and total and live litter sex ratios were not significantly affected by genistein. However, average weight per live pup at birth and offspring body weights from PND 42-77 were significantly decreased in the 1250-ppm group. Body weight and food intake for the dams were also significantly decreased in the 1250-ppm group. These results indicate that developmental genistein treatment, at levels that decrease maternal and offspring body weight, causes subtle alterations in some sexually dimorphic behaviors. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Flynn, K M AU - Ferguson, S A AU - Delclos, K B AU - Newbold, R R AD - Division of Neurotoxicology and Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. kflynn@nctr.fda.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 311 EP - 319 VL - 55 IS - 2 SN - 1096-6080, 1096-6080 KW - Growth Inhibitors KW - 0 KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Rats KW - Eating -- drug effects KW - Animals, Newborn KW - Animals KW - Rats, Sprague-Dawley KW - Reproduction -- drug effects KW - Endocrine System Diseases -- chemically induced KW - Body Weight -- drug effects KW - Feeding Behavior -- drug effects KW - Maternal Exposure KW - Male KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Sexual Behavior, Animal -- drug effects KW - Sex Characteristics KW - Genistein -- pharmacology KW - Growth Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71149484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Effects+of+genistein+exposure+on+sexually+dimorphic+behaviors+in+rats.&rft.au=Flynn%2C+K+M%3BFerguson%2C+S+A%3BDelclos%2C+K+B%3BNewbold%2C+R+R&rft.aulast=Flynn&rft.aufirst=K&rft.date=2000-06-01&rft.volume=55&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-11 N1 - Date created - 2000-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating factors to convert Chinese 'Total Dust' measurements to ACGIH respirable concentrations in metal mines and pottery industries. AN - 71147107; 10831729 AB - Historical data on the dust exposures of Chinese workers in metal mines (iron/copper, tin, tungsten) and pottery industries are being used in an ongoing joint Chinese/United States epidemiological study to investigate the exposure-response relationship for the development of silicosis, lung cancer, and other diseases. The historical data include 'total dust' concentrations determined by a Chinese method. Information about particle size distribution and the chemical and mineralogical content of airborne particles is generally not available. In addition, the historical Chinese sampling strategy is different from a typical American eight-hour time-weighted average (TWA) sampling strategy, because the Chinese samples were collected for approximately 15 minutes during production so the sample could be compared to their maximum allowable concentration (MAC) standard. Therefore, in order to assess American respirable dust exposure standards in light of the Chinese experience, factors are needed to convert historical Chinese total dust concentrations to respirable dust concentrations. As a part of the joint study to estimate the conversion factors, airborne dust samples were collected in 20 metal mines and 9 pottery factories in China during 1988 and 1989 using three different samplers: 10mm nylon cyclones, multi-stage 'cassette' impactors, and the traditional Chinese total dust samplers. More than 100 samples were collected and analysed for each of the three samplers. The study yielded two different estimates of the conversion factor from the Chinese total dust concentrations (measured during production processes) to respirable dust concentrations. The multivariate analysis of variance (MANOVA) reveals that, with a fixed sampling/analysis method, conversion factors were not statistically different among the different job titles within each industry. It also indicates that conversion factors among the industries were not statistically different. However, the two estimates consistently showed that conversion factors were the lowest in the pottery industry. Average conversion factors were then calculated for each of the estimates across the industries studied. A pooled mean conversion factor, 0.25+/-0.04, was then derived for all the job titles and industries. Respirable dust levels were estimated from the historical 'total dust' concentrations collected between 1952 and 1992 by adopting the American standard. JF - The Annals of occupational hygiene AU - Gao, P AU - Chen, B T AU - Hearl, F J AU - McCawley, M A AU - Schwerha, D J AU - Odencrantz, J AU - Chen, W AU - Chen, J AU - Soderholm, S C AD - National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. pcg@cdc.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 251 EP - 257 VL - 44 IS - 4 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Index Medicus KW - Regression Analysis KW - Reference Values KW - Humans KW - China KW - Multivariate Analysis KW - Ceramics KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Mining KW - Environmental Monitoring -- statistics & numerical data KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71147107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Estimating+factors+to+convert+Chinese+%27Total+Dust%27+measurements+to+ACGIH+respirable+concentrations+in+metal+mines+and+pottery+industries.&rft.au=Gao%2C+P%3BChen%2C+B+T%3BHearl%2C+F+J%3BMcCawley%2C+M+A%3BSchwerha%2C+D+J%3BOdencrantz%2C+J%3BChen%2C+W%3BChen%2C+J%3BSoderholm%2C+S+C&rft.aulast=Gao&rft.aufirst=P&rft.date=2000-06-01&rft.volume=44&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-20 N1 - Date created - 2000-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bioassays of shortened duration for drugs: statistical implications. AN - 71145587; 10828275 AB - Declining survival rates in rodent carcinogenesis bioassays have raised a concern that continuing the practice of terminating such studies at 24 months could result in too few live animals at termination for adequate pathological evaluation. One option for ensuring sufficient numbers of animals at the terminal sacrifice is to shorten the duration of the bioassay, but this approach is accompanied by a reduction in statistical power for detecting carcinogenic potential. The present study was conducted to evaluate the loss of power associated with early termination. Data from drug studies in rats were used to formulate biologically based dose-response models of carcinogenesis using the 2-stage clonal expansion model as a context. These dose-response models, which were chosen to represent 6 variations of the initiation-promotion-completion cancer model, were employed to generate a large number of representative bioassay data sets using Monte Carlo simulation techniques. For a variety of tumor dose-response trends, tumor lethality, and competing risk-survival rates, the power of age-adjusted statistical tests to assess the significance of carcinogenic potential was evaluated at 18 and 21 months, and compared to the power at the normal 24-month stopping time. The results showed that stopping at 18 months would reduce power to an unacceptable level for all 6 submodels of the 2-stage clonal expansion model, with the pure-promoter and pure-completer models being most adversely affected. For the 21-month stopping time, the results showed that, unless pure promotion can be ruled out a priori as a potential carcinogenic mode of action, the loss of power is too great to warrant early stopping. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Kodell, R L AU - Lin, K K AU - Thorn, B T AU - Chen, J J AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. rkodell@nctr.fda.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 415 EP - 432 VL - 55 IS - 2 SN - 1096-6080, 1096-6080 KW - Carcinogens KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - Survival Rate -- trends KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Cocarcinogenesis KW - Dose-Response Relationship, Drug KW - Rats, Wistar KW - Disease Models, Animal KW - Models, Statistical KW - Monte Carlo Method KW - Time Factors KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity KW - Carcinogenicity Tests -- methods KW - Neoplasms, Experimental -- mortality KW - Biological Assay -- statistics & numerical data KW - Drugs, Investigational -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71145587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Bioassays+of+shortened+duration+for+drugs%3A+statistical+implications.&rft.au=Kodell%2C+R+L%3BLin%2C+K+K%3BThorn%2C+B+T%3BChen%2C+J+J&rft.aulast=Kodell&rft.aufirst=R&rft.date=2000-06-01&rft.volume=55&rft.issue=2&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-11 N1 - Date created - 2000-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft. AN - 71143694; 10828036 AB - Clinically advanced and rapidly progressive AIDS-associated Kaposi sarcoma (AIDS-KS) tumors require an aggressive tumor-directed therapy. We have observed that AIDS-KS cells express high levels of receptors for immune regulatory cytokine, interleukin-13 (IL-13). Two tumorigenic AIDS-KS cell lines, KS Y-1 and KS-imm, expressed 4560 and 9480 IL-13 binding sites per cell with an affinity (kd) of approximately 0.9 and 3.7 nmol/L, respectively. IL-13 cytotoxin IL13-PE38QQR, consisting of human IL-13 and a derivative of Pseudomonas exotoxin, is specifically cytotoxic to KS tumor cells. Systemic and loco regional administration of IL13-PE38QQR in immunodeficient mice with established human KS tumors produced remarkable antitumor activity. Three intratumoral (IT) injections of IL-13 toxin (250 microg/kg per dose) on alternate days (qod) or 5 daily (qd) IT injections with lower doses (50 or 100 microg/kg per dose) resulted in a complete regression of established subcutaneous tumors in most animals. Daily IT treatment with 250 microg/kg of IL-13 toxin in another KS-derived cell line also produced complete responses. Twice daily intraperitoneal injections of IL13-PE38QQR (25 or 50 microg/kg per dose) for 10 days (total injections = 20) also completely eradicated KS Y-1 tumors. Intravenous administration of IL13-PE38QQR also suppressed tumor growth; however, complete responses were not observed. All animals tolerated the therapeutic doses of IL-13 toxin without any visible signs of toxicity. The efficacy of receptor-directed IL13-PE38QQR therapy in mice warrants further exploration of this drug for AIDS-KS treatment. JF - Blood AU - Husain, S R AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000/06/01/ PY - 2000 DA - 2000 Jun 01 SP - 3506 EP - 3513 VL - 95 IS - 11 SN - 0006-4971, 0006-4971 KW - Bacterial Toxins KW - 0 KW - Exotoxins KW - IL13RA1 protein, human KW - Il13ra1 protein, mouse KW - Immunotoxins KW - Interleukin-13 KW - Interleukin-13 Receptor alpha1 Subunit KW - Receptors, Interleukin KW - Receptors, Interleukin-13 KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Injections, Intraperitoneal KW - Animals KW - Receptors, Interleukin -- metabolism KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Mice KW - Mice, Nude KW - Tumor Cells, Cultured KW - Receptors, Interleukin -- drug effects KW - Female KW - Immunotoxins -- pharmacokinetics KW - Sarcoma, Kaposi -- drug therapy KW - Exotoxins -- administration & dosage KW - Interleukin-13 -- therapeutic use KW - Acquired Immunodeficiency Syndrome KW - Immunotoxins -- therapeutic use KW - Immunotoxins -- administration & dosage KW - Exotoxins -- therapeutic use KW - Exotoxins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71143694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Interleukin-13+fusion+cytotoxin+as+a+potent+targeted+agent+for+AIDS-Kaposi%27s+sarcoma+xenograft.&rft.au=Husain%2C+S+R%3BPuri%2C+R+K&rft.aulast=Husain&rft.aufirst=S&rft.date=2000-06-01&rft.volume=95&rft.issue=11&rft.spage=3506&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-29 N1 - Date created - 2000-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality among rubber chemical manufacturing workers. AN - 71122672; 10797502 AB - A retrospective cohort mortality study evaluated ischemic heart disease (IHD) among workers in the "rubber chemicals" manufacturing department of a Western New York plant. A previous study at the plant found elevated chest pain and angina among workers in this department. Mortality experience of workers employed from 1946-1988 was followed through December 31, 1994. Mortality was compared to U.S. population rates and to local Niagara county rates by using the NIOSH life table analysis system. Poisson regression was used to examine patterns of IHD within the cohort. The standardized mortality ratio (SMR) for IHD among workers in the rubber chemicals department was 1.51 (U.S. rates) and 1.19 (Niagara county rates). Increased mortality from IHD in the rubber chemicals department was most pronounced at younger ages (< 50, SMR = 2.4); workers in a second chemical production department also had an elevated (but not statistically significant) SMR of 1.5 for IHD. IHD mortality among workers in the rubber chemicals department was elevated, particularly among those under 50 years of age. Potential occupational risk factors for IHD include the rotating shift pattern for employees assigned to two chemical production departments and chemical exposures present in the rubber chemicals department. JF - American journal of industrial medicine AU - Prince, M M AU - Ward, E M AU - Ruder, A M AU - Salvan, A AU - Roberts, D R AD - National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluation, and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA. mmp3@cdc.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 590 EP - 598 VL - 37 IS - 6 SN - 0271-3586, 0271-3586 KW - Polyvinyl Chloride KW - 9002-86-2 KW - Rubber KW - 9006-04-6 KW - Index Medicus KW - United States KW - Cross-Sectional Studies KW - New York KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - Adult KW - Retrospective Studies KW - Incidence KW - Aged KW - Middle Aged KW - Adolescent KW - National Institute for Occupational Safety and Health (U.S.) KW - Cause of Death KW - Neoplasms -- mortality KW - Rubber -- adverse effects KW - Neoplasms -- chemically induced KW - Myocardial Ischemia -- mortality KW - Myocardial Ischemia -- chemically induced KW - Polyvinyl Chloride -- adverse effects KW - Occupational Diseases -- chemically induced KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71122672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Mortality+among+rubber+chemical+manufacturing+workers.&rft.au=Prince%2C+M+M%3BWard%2C+E+M%3BRuder%2C+A+M%3BSalvan%2C+A%3BRoberts%2C+D+R&rft.aulast=Prince&rft.aufirst=M&rft.date=2000-06-01&rft.volume=37&rft.issue=6&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-21 N1 - Date created - 2000-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 2001 Oct;40(4):393-6 [11598988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure-function studies of the self-assembly domain of the human immunodeficiency virus type 1 transmembrane protein gp41. AN - 71094084; 10799616 AB - The coiled-coil region of the human immunodeficiency virus type 1 transmembrane protein (gp41) makes up the interior core of the six-helix bundle structure of the gp41 self-assembly domain. We extended our previous study of this domain (Y. Weng and C. D. Weiss, J. Virol. 72:9676-9682, 1998) by analyzing 23 additional mutants at positions that lie at the interface of the interior core and outer helices. We found nine new functional mutants. For most mutants, the activity could be explained by the ability of the modeled mutants to stabilize the six-helix bundle structure. The present study provides insights into the envelope glycoprotein fusion mechanism and information for rational drug and vaccine design. JF - Journal of virology AU - Weng, Y AU - Yang, Z AU - Weiss, C D AD - Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 5368 EP - 5372 VL - 74 IS - 11 SN - 0022-538X, 0022-538X KW - HIV Envelope Protein gp41 KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Mutagenesis, Site-Directed KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Hydrogen Bonding KW - Structure-Activity Relationship KW - Binding Sites KW - HIV-1 -- genetics KW - HIV Envelope Protein gp41 -- metabolism KW - HIV Envelope Protein gp41 -- genetics KW - HIV Envelope Protein gp41 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71094084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Structure-function+studies+of+the+self-assembly+domain+of+the+human+immunodeficiency+virus+type+1+transmembrane+protein+gp41.&rft.au=Weng%2C+Y%3BYang%2C+Z%3BWeiss%2C+C+D&rft.aulast=Weng&rft.aufirst=Y&rft.date=2000-06-01&rft.volume=74&rft.issue=11&rft.spage=5368&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-27 N1 - Date created - 2000-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1993 May;67(5):2747-55 [8474172] J Virol. 1999 Mar;73(3):2469-80 [9971832] Nature. 1993 Sep 9;365(6442):113 [8371754] J Virol. 1994 Feb;68(2):654-60 [7507183] J Virol. 1994 Mar;68(3):2002-10 [7509005] Nat Struct Biol. 1995 Dec;2(12):1075-82 [8846219] Cell. 1997 Apr 18;89(2):263-73 [9108481] Nature. 1997 May 22;387(6631):426-30 [9163431] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8 [9356444] J Virol. 1998 Feb;72(2):986-93 [9444991] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9134-9 [9689046] EMBO J. 1998 Aug 17;17(16):4572-84 [9707417] J Virol. 1998 Dec;72(12):9676-82 [9811701] J Virol. 1999 May;73(5):4433-8 [10196341] J Struct Biol. 1999 Jun 15;126(2):131-44 [10388624] J Virol. 1993 Jun;67(6):3615-9 [8497069] J Virol. 1992 Aug;66(8):4748-56 [1629954] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15613-7 [9861018] Erratum In: J Virol 2000 Oct;74(20):9811 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - International society of regulatory toxicology and pharmacology 1999 international achievement award AN - 1859324024; 10915583 JF - Regulatory toxicology and pharmacology : RTP AU - Rulis AD - Office of Premarket Approval, Center for Food Safety and Applied Nutrition, Washington, DC, 20204, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 244 EP - 247 VL - 31 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859324024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=International+society+of+regulatory+toxicology+and+pharmacology+1999+international+achievement+award&rft.au=Rulis&rft.aulast=Rulis&rft.aufirst=&rft.date=2000-06-01&rft.volume=31&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2000-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carbon monoxide poisoning: how about more precise analytic and preanalytic techniques? AN - 1859321908; 10828783 JF - Annals of emergency medicine AU - Deitchman AU - Decker AU - Santis AD - National Institute for Occupational Safety and Health National Center for Environmental HealthCenters for Disease Control and Prevention, Atlanta, GA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 630 EP - 631 VL - 35 IS - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859321908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+emergency+medicine&rft.atitle=Carbon+monoxide+poisoning%3A+how+about+more+precise+analytic+and+preanalytic+techniques%3F&rft.au=Deitchman%3BDecker%3BSantis&rft.aulast=Deitchman&rft.aufirst=&rft.date=2000-06-01&rft.volume=35&rft.issue=6&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Annals+of+emergency+medicine&rft.issn=1097-6760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2000-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lung function prediction equations derived from healthy South African gold miners AN - 17729715; 4791806 AB - Objectives - To estimate lung function prediction equations and to identify appropriate normal reference values for the population of about 250 000 of South African gold miners. Methods - Data from a lung function screening programme conducted at a large South African gold mine from 1994 to 1998 were used to estimate the lung function prediction equations. The most reliable period of lung function testing was identified in a previous study of a temporal pattern in reliability, and lung function tests from this period were used. Miners with a history of pulmonary tuberculosis or with radiological abnormalities were excluded from the study. The prediction equations were estimated cross sectionally on 15 772 black and 2752 white miners, and published reference equations that fitted most closely the observed data were identified. Results - The estimated prediction equations for forced vital capacity (FVC) are as follows: for black men, FVC (1)=-2.901-0.025xage+4.655xheight; and for white men, FVC(1)=-4.407-0.036xage+5.940xheight. For forced expiratory volume in one second (FEV sub(1)) these equations are: for black men, FEV sub(1)(1)=-1.654- 0.30xage+3.665xheight; and for white men, FEV sub(1)(1)=-2.341- 0.038xage+4.314xheight. Units are years for age and metres for height. Knudson's and the European Community of Coal and Steel (ECCS) reference values provided the closest fit to the data on lung function of white miners, but the lower limits of normal from the ECCS equations were the closest to the observed one sided lower 95% confidence intervals (95% CIs). For black miners, reference equations that fitted best were derived by Louw et al on asymptomatic black South African men unexposed to occupational dust. There were significant differences between the two groups of miners in the estimated height adjusted mean lung function values for a 40 year old 1.7 m tall man (220 ml (5.2%) for FVC and 110 ml (3.2%) for FEV sub(1)); white men had higher FVC and FEV sub(1), but lower FEV sub(1)/FVC ratio. The ECCS reference values scaled by a conversion factor of 0.93 for the FVC and 0.95 for the FEV sub(1) provided close fits to the data for black miners, but the rate of decline with age was higher than that in the observed data. None of the linear equations provided a good fit for the 20-29 and more than 55 years old age categories. Conclusion - The ECCS and Knudson equations provided the best fit to the data for white miners, whereas the equations by Louw et al estimated on asymptomatic black South African bank workers provided the best fit to the data for black miners. The ECCS reference values scaled by a factor of 0.93 for FVC and by 0.95 for FEV sub(1) provided close fits, but the rate of decline with age was higher than that in the data for black miners. JF - Occupational and Environmental Medicine AU - Hnizdo, E AU - Churchyard, G AU - Dowdeswel, R AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS 2800, Morgantown, WV 26505, USA, exhb@cdc.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 698 EP - 705 VL - 57 IS - 10 SN - 1351-0711, 1351-0711 KW - South Africa KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Dust KW - Gold KW - Mining KW - Respiratory function KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17729715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Lung+function+prediction+equations+derived+from+healthy+South+African+gold+miners&rft.au=Hnizdo%2C+E%3BChurchyard%2C+G%3BDowdeswel%2C+R&rft.aulast=Hnizdo&rft.aufirst=E&rft.date=2000-06-01&rft.volume=57&rft.issue=10&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Respiratory function; Gold; Mining; Occupational exposure; Dust ER - TY - JOUR T1 - Outbreaks of Vibrio parahaemolyticus gastroenteritis from raw oyster consumption: Assessing the risk of consumption and genetic methods for detection of pathogenic strains AN - 17630799; 4774409 AB - During the summers of 1997 and 1998, large outbreaks of V. parahaemolyticus gastroenteritis occurred from the consumption of raw oysters in the US. The West Coast outbreak was the first to have occurred in this country from the consumption of raw molluscan shellfish; over 200 culture-confirmed cases were identified. Over 400 cases were confirmed from oysters harvested from Galveston Bay in Texas and 20 cases were confirmed in New York and Connecticut from oysters originating from Long Island Sound. Distinct serogroups of the pathogen were responsible for illnesses on the West Coast in contrast to those on the East and Gulf Coasts. Monitoring of shellfish samples by State and federal authorities found low levels of V. parahaemolyticus in all implicated growing areas, suggesting strains of low infectious dose. FDA has completed a risk assessment study for consumption of raw molluscan shellfish as part of the Food Safety Initiative. Newly developed genetic techniques were employed for the first time to determine levels of V. parahaemolyticus in shellfish and detect the pathogenic strains of the species. JF - Journal of Shellfish Research AU - Kaysner, CA AU - DePaola, A Jr AD - Food and Drug Administration, Bothell, WA 98021, USA Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 657 PB - National Shellfisheries Association VL - 19 IS - 1 SN - 0730-8000, 0730-8000 KW - gastroenteritis KW - raw oysters KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA Aquaculture Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine KW - Human diseases KW - ANW, USA, Long Island Sound KW - Shellfish fisheries KW - USA, Connecticut KW - Bacterial diseases KW - Pollution effects KW - Food poisoning KW - Oyster culture KW - ASW, USA, Texas, Galveston Bay KW - USA, New York KW - Public health KW - Bioaccumulation KW - Vibrio parahaemolyticus KW - Oyster fisheries KW - Q3 08583:Shellfish culture KW - Q1 08484:Species interactions: parasites and diseases KW - O 5020:Fisheries and Fishery Biology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17630799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Shellfish+Research&rft.atitle=Outbreaks+of+Vibrio+parahaemolyticus+gastroenteritis+from+raw+oyster+consumption%3A+Assessing+the+risk+of+consumption+and+genetic+methods+for+detection+of+pathogenic+strains&rft.au=Kaysner%2C+CA%3BDePaola%2C+A+Jr&rft.aulast=Kaysner&rft.aufirst=CA&rft.date=2000-06-01&rft.volume=19&rft.issue=1&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Journal+of+Shellfish+Research&rft.issn=07308000&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Human diseases; Bioaccumulation; Shellfish fisheries; Bacterial diseases; Food poisoning; Pollution effects; Oyster culture; Oyster fisheries; Public health; Vibrio parahaemolyticus; ANW, USA, Long Island Sound; USA, Connecticut; ASW, USA, Texas, Galveston Bay; USA, New York; Marine ER - TY - JOUR T1 - Deep cut: ground control and worker safety in coal mines AN - 17629363; 4778798 AB - The trend in underground room-and-pillar coal mining is to employ remote-controlled, continuous-mining machines and extended cuts to depths of 12 m (40 ft) or more. This system of coal extraction, adopted by more than 435 mines, can create additional worker safety hazards. To address the ground-control-related safety hazards, a combination of statistical analysis and numerical modeling was used. Initially, the reported roof-fall incidents and fatalities were reviewed to delineate the ground-control hazards. Then, the application of the coal mine roof rating (CMRR) for estimating safe extended-cut depths was evaluated. Finally, computer modeling was completed to predict roof displacements during extended-cut mining. This paper describes the results of these studies and their impacts on the safety of extended-cut mining. JF - Mining Engineering AU - Bauer, E R AU - Bise, C J AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, USA Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 110 EP - 112 VL - 52 IS - 6 SN - 0026-5187, 0026-5187 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Injuries KW - Occupational safety KW - Mining KW - Coal KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17629363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Deep+cut%3A+ground+control+and+worker+safety+in+coal+mines&rft.au=Bauer%2C+E+R%3BBise%2C+C+J&rft.aulast=Bauer&rft.aufirst=E&rft.date=2000-06-01&rft.volume=52&rft.issue=6&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; Risk assessment; Coal; Mining; Injuries ER - TY - JOUR T1 - Inhibition of Human Immunodeficiency Virus Type 1 by Packageable, Multigenic Antisense RNA AN - 17604318; 4744006 AB - Viral-based vectors can provide an efficient delivery mechanism for stable expression of antisense RNA. To enhance and propagate the antiviral effect of antisense RNA, two novel human immunodeficiency virus type 1 (HIV-1)-based vector DNAs, designated as pMAG7 and pMAG19, were constructed which contained HIV-1 cis-acting packaging elements and produced multigenic HIV-1 antisense RNA that could target the entire pol, env, vif, vpu, vpr, rev, and tat and portions of gag and nef. The two DNAs were identical except that pMAG19 had additional gag coding sequences. Cotransfection of pMAG DNA and infectious, cloned HIV-1 DNA in 293 cells inhibited virus production (81%-98% reduction in reverse transcriptase activity) of various T cell-tropic and macrophage-tropic clade B isolates, such as NL4-3, YU-2, and JR-CSF. In addition, virion-associated pMAG antisense RNA was detected in residual virus particles produced by pNL4-3 in the presence of pMAG7 DNA, and the antisense sequences were stably transferred by infection of 174 x CEM cells. The results suggest that pMAG DNA may confer broad protection against HIV-1 by reducing initial virus burden due to antisense RNA and subsequent virus spread by propagation of antisense sequences along with wild-type virus. JF - Antisense and Nucleic Acid Drug Development AU - Shahabuddin, M AU - Khan, A S AD - Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM-454, Rockville, MD 20852-1448, USA Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 141 EP - 151 VL - 10 IS - 3 SN - 1087-2906, 1087-2906 KW - HIV-1 KW - Human immunodeficiency virus 1 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Plasmids KW - Expression vectors KW - Antisense KW - Antiviral agents KW - RNA KW - Transfection KW - V 22002:AIDS: Molecular and in vitro aspects KW - N 14560:Antisense research KW - W 30965:Miscellaneous, Reviews KW - W3 33380:Antisense UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17604318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antisense+and+Nucleic+Acid+Drug+Development&rft.atitle=Inhibition+of+Human+Immunodeficiency+Virus+Type+1+by+Packageable%2C+Multigenic+Antisense+RNA&rft.au=Shahabuddin%2C+M%3BKhan%2C+A+S&rft.aulast=Shahabuddin&rft.aufirst=M&rft.date=2000-06-01&rft.volume=10&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Antisense+and+Nucleic+Acid+Drug+Development&rft.issn=10872906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Plasmids; Antisense; RNA; Expression vectors; Transfection; Antiviral agents ER - TY - JOUR T1 - DNA vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity AN - 17599362; 4734018 AB - Genetic immunization is a promising new technology for developing vaccines against tuberculosis that are more effective. In the present study, we evaluated the effects of intracellular turnover of antigens expressed by DNA vaccines on the immune response induced by these vaccines in a mouse model of pulmonary tuberculosis. The mycobacterial culture filtrate protein MPT64 was expressed as a chimeric protein fused to one of three variants of the ubiquitin protein (UbG, UbA, and UbGR) known to differentially affect the intracellular processing of the coexpressed antigens. Immunoblot analysis of cell lysates of in vitro-transfected cells showed substantial differences in the degradation rate of ubiquinated MPT64 (i.e., UbG64 < UbA64 < UbGR64). The specific immune response generated in mice correlated with the stability of the ubiquitin-conjugated antigen. The UbA64 DNA vaccine induced a weak humoral response compared to UbG64, and a mixed population of interleukin-4 (IL-4)- and gamma interferon (IFN- gamma )-secreting cells. Vaccination with the UbGR64 plasmid generated a strong Th1 cell response (high IFN- gamma , low IL-4) in the absence of a detectable humoral response. Aerogenic challenge of vaccinated mice with Mycobacterium tuberculosis indicated that immunization with both the UbA64- and UbGR64-expressing plasmids evoked an enhanced protective response compared to the vector control. The expression of mycobacterial antigens from DNA vaccines as fusion proteins with a destabilizing ubiquitin molecule (UbA or UbGR) shifted the host response toward a stronger Th1-type immunity which was characterized by low specific antibody levels, high numbers of IFN- gamma -secreting cells, and significant resistance to a tuberculous challenge. JF - Infection and Immunity AU - Delogu, G AU - Howard, A AU - Collins, F M AU - Morris, S L AD - Laboratory of Mycobacteria, OVRR/CBER/FDA, HFM-431, Bldg. 29, Rm. 502, 29 Lincoln Dr., Bethesda, MD 20892, USA, morris@cber.fda.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 3097 EP - 3102 VL - 68 IS - 6 SN - 0019-9567, 0019-9567 KW - mice KW - immunology KW - DNA vaccine KW - Mycobacterium tuberculosis KW - ubiquitin KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Lung diseases KW - Vaccination KW - Gene expression KW - Immune response (cell-mediated) KW - DNA vaccines KW - ^g-Interferon KW - Tuberculosis KW - Vaccines KW - Ubiquitin KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17599362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=DNA+vaccination+against+tuberculosis%3A+expression+of+a+ubiquitin-conjugated+tuberculosis+protein+enhances+antimycobacterial+immunity&rft.au=Delogu%2C+G%3BHoward%2C+A%3BCollins%2C+F+M%3BMorris%2C+S+L&rft.aulast=Delogu&rft.aufirst=G&rft.date=2000-06-01&rft.volume=68&rft.issue=6&rft.spage=3097&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.6.3097-3102.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Tuberculosis; DNA vaccines; Vaccines; Lung diseases; Vaccination; Ubiquitin; Immune response (cell-mediated); ^g-Interferon; Gene expression DO - http://dx.doi.org/10.1128/IAI.68.6.3097-3102.2000 ER - TY - JOUR T1 - Inactivation of indicator microorganisms in estuarine waters AN - 17594548; 4714807 AB - In the United States, shellfish growing areas are classified, in part, using standards based on the densities of either the total or fecal coliform groups in surface waters. However, the standards currently employed may not reliably index the presence of certain enteric pathogens, particularly enteric viruses responsible for human illnesses, even though both the pathogens and indicators derive from the same fecal contamination. To some extent, this may be due to differences in the survival of these pathogens in the environment relative to that of the bacterial indicators. This investigation was conducted to assess the effects of temperature, salinity, dissolved oxygen, geographic location, season, and solar radiation on the survival of selected indicator microorganisms in estuarine waters. The indicators examined included fecal coliforms, Escherichia coli, Clostridium perfringens, and male-specific bacteriophage (MSB), a potential indicator of enteric viruses. In situ experiments were performed in estuarine waters of Alabama and Rhode Island. Among the parameters examined, sunlight and/or temperature most significantly affected indicator decay rates. In general, the effects from exposure to sunlight accounted for up to 83, 84, and 99% of the density reductions of MSB, C. perfringens and fecal coliforms, respectively. Thus, the effects from sunlight were greatest on fecal coliforms and much less pronounced on MSB and C. perfringens. For fecal coliforms, the effect of sunlight was more pronounced during the winter than the summer. In the absence of sunlight, the rate of MSB decline was strongly negatively correlated with estuarine water temperatures and dissolved oxygen. Overall, fecal coliform decay rates were dissimilar to those found for MSB. From this, it would appear that fecal coliforms may not be reliable indicators of viruses in estuarine waters. JF - Water Research AU - Burkhardt, W III AU - Calci, K R AU - Watkins, W D AU - Rippey AU - Chirtel, S J AD - US Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528-0158, USA, wburkhar@vm.cfsan.fda.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 2207 EP - 2214 VL - 34 IS - 8 SN - 0043-1354, 0043-1354 KW - Bacteria KW - Enteric viruses KW - Fecal coliform groups KW - Male specific bacteriophage KW - USA, Alabama KW - USA, Rhode Island KW - survival KW - Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Water Resources Abstracts KW - ASW, USA, Alabama KW - Viruses KW - Indicators KW - Population density KW - Microbial contamination KW - Dissolved oxygen KW - Enteroviruses KW - Escherichia coli KW - Temperature Effects KW - Solar Radiation KW - Experimental Data KW - Micro-organisms KW - Pathogenic bacteria KW - Estuaries KW - Brackish KW - ANW, USA, Rhode Island KW - Viruses (Enteric) KW - Microorganisms KW - Pathogenic organism KW - Oxygen (Dissolved) KW - Pollution monitoring KW - Human diseases KW - Survival KW - Solar radiation KW - Bacteria (Coliform) KW - Temperature effects KW - Coliforms KW - Brackishwater pollution KW - Clostridium perfringens KW - Dissolved Oxygen KW - Pathogens KW - Light effects KW - Aquatic microorganisms KW - Indicator species KW - A 01105:Non-patents KW - Q1 08422:Environmental effects KW - Q5 08502:Methods and instruments KW - AQ 00003:Monitoring and Analysis of Water and Wastes KW - SW 0890:Estuaries KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17594548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Inactivation+of+indicator+microorganisms+in+estuarine+waters&rft.au=Burkhardt%2C+W+III%3BCalci%2C+K+R%3BWatkins%2C+W+D%3BRippey%3BChirtel%2C+S+J&rft.aulast=Burkhardt&rft.aufirst=W&rft.date=2000-06-01&rft.volume=34&rft.issue=8&rft.spage=2207&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2FS0043-1354%2899%2900399-1 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Temperature effects; Pollution monitoring; Human diseases; Pathogenic bacteria; Brackishwater pollution; Viruses; Estuaries; Population density; Survival; Microbial contamination; Pathogens; Light effects; Microorganisms; Indicator species; Aquatic microorganisms; Coliforms; Solar radiation; Dissolved oxygen; Micro-organisms; Viruses (Enteric); Indicators; Pathogenic organism; Oxygen (Dissolved); Bacteria (Coliform); Experimental Data; Solar Radiation; Enteroviruses; Dissolved Oxygen; Temperature Effects; Bacteria; Clostridium perfringens; Escherichia coli; ASW, USA, Alabama; ANW, USA, Rhode Island; Brackish DO - http://dx.doi.org/10.1016/S0043-1354(99)00399-1 ER - TY - JOUR T1 - Immunological Responses of Mice following Administration of Natural Rubber Latex Proteins by Different Routes of Exposure AN - 17560388; 4746357 AB - Although the prevalence of IgE-mediated latex allergy has increased over the past decade, the circumstances which culminate in sensitization remain uncertain. The objective of these studies was to evaluate the role which sensitization route plays in the development of latex allergy using murine models representative of potential exposure routes by which health care workers (topical and respiratory) and spina bifida patients (subcutaneous) may be sensitized. BALB/c mice administered latex proteins by the subcutaneous, topical, intranasal, or intratracheal routes exhibited dose-responsive elevations in total IgE. In vitro splenocyte stimulation initially demonstrated specificity of the murine immune response to latex proteins. Subsequently, immunoblot analysis was used to compare latex-specific IgE production amongst sensitization routes. Immunoblots of IgE from subcutaneously sensitized mice demonstrated recognition of latex proteins with molecular weights near 14 kDa and 27 kDa. These protein sizes are consistent with the molecular weights of major latex allergens (Hev b 1 and Hev b 3), to which high percentages of spina bifida patients develop antibodies. Mice sensitized by intratracheal or topical administration exhibited combined IgE recognition of latex proteins near 14 kDa, 35 kDa, and 92 kDa. These molecular weights are similar to other latex allergens (Hev b 6, Hev b 2, and Hev b 4) commonly recognized by IgE of health care workers. Mice sensitized to latex proteins by topical, intranasal, or intratracheal exposures exhibited bronchoconstriction as evaluated by whole body plethysmography following respiratory challenge with latex proteins. Subcutaneously sensitized mice were unresponsive. These differences in latex-specific IgE immunoblot profiles and altered pulmonary function amongst the four different sensitization routes suggest that exposure routes leading to sensitization may play a role in determining the primary allergen(s), and the clinical manifestation of the allergic responses. JF - Toxicological Sciences AU - Woolhiser, M R AU - Munson, A E AU - Meade, B J AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 343 EP - 351 VL - 55 IS - 2 SN - 1096-6080, 1096-6080 KW - natural rubber KW - mice KW - Toxicology Abstracts KW - Immunoglobulin E KW - Rubber KW - Latex KW - Immune response (humoral) KW - X 24151:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17560388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Immunological+Responses+of+Mice+following+Administration+of+Natural+Rubber+Latex+Proteins+by+Different+Routes+of+Exposure&rft.au=Woolhiser%2C+M+R%3BMunson%2C+A+E%3BMeade%2C+B+J&rft.aulast=Woolhiser&rft.aufirst=M&rft.date=2000-06-01&rft.volume=55&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Immune response (humoral); Rubber; Immunoglobulin E; Latex ER - TY - JOUR T1 - Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization AN - 17548892; 4734110 AB - Recently, concern has been voiced about the potential effect that antigenic divergence of circulating strains of Bordetella pertussis might have on the efficacy of pertussis vaccines. In order to model antigenic drift of pertussis toxin, a critical component of many pertussis vaccines, and to examine the effects of such drift on antibody neutralization, we engineered a strain of B. pertussis to produce a variant pertussis toxin molecule that contains many of the amino acid changes found in the toxin encoded by Bordetella bronchiseptica ptx genes. This altered form of the toxin, which is efficiently secreted by B. pertussis and which displays significant biological activity, was found to be neutralized by antibodies induced by vaccination as readily as toxin produced by wild-type B. pertussis. These findings suggest that significant amino acid changes in the pertussis toxin sequence can occur without drastically altering the ability of antibodies to recognize and neutralize the toxin molecule. JF - Infection and Immunity AU - Hausman, S Z AU - Burns, D L AD - CBER/FDA, HFM-434, Building 29, Room 418, 8800 Rockville Pike, Bethesda, MD 20892, USA, burns@cber.fda.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 3763 EP - 3767 VL - 68 IS - 6 SN - 0019-9567, 0019-9567 KW - animal models KW - immunology KW - Bordetella bronchiseptica KW - ptx gene KW - Immunology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Antibody response KW - Toxins KW - Antibodies KW - Antigenic drift KW - Vaccines KW - Neutralization KW - Genetic code KW - J 02832:Antigenic properties and virulence KW - F 06807:Active immunization KW - G 07320:Bacterial genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17548892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Use+of+pertussis+toxin+encoded+by+ptx+genes+from+Bordetella+bronchiseptica+to+model+the+effects+of+antigenic+drift+of+pertussis+toxin+on+antibody+neutralization&rft.au=Hausman%2C+S+Z%3BBurns%2C+D+L&rft.aulast=Hausman&rft.aufirst=S&rft.date=2000-06-01&rft.volume=68&rft.issue=6&rft.spage=3763&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.6.3763-3767.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bordetella bronchiseptica; Pertussis; Toxins; Vaccines; Antibody response; Neutralization; Antigenic drift; Antibodies; Genetic code DO - http://dx.doi.org/10.1128/IAI.68.6.3763-3767.2000 ER - TY - JOUR T1 - Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus AN - 17548845; 4734189 AB - Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%). JF - Applied and Environmental Microbiology AU - Parshikov, IA AU - Freeman, J P AU - Lay, JO Jr AU - Beger, R D AU - Williams, A J AU - Sutherland, J B AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079-9502, USA, jsutherland@nctr.fda.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 2664 EP - 2667 VL - 66 IS - 6 SN - 0099-2240, 0099-2240 KW - transformation KW - culture KW - metabolites KW - Desethylene-enrofloxacin KW - Enrofloxacin KW - Enrofloxacin N-oxide KW - Enrofloxacine N-oxide KW - N-Acetylciprofloxacin KW - fluoroquinolones KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Veterinary medicine KW - Antifungal agents KW - Fluoroquinolones KW - Mucor ramannianus KW - quinolines KW - A 01067:Antifungal & fungicidal KW - K 03098:Spoilage & biodegradation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17548845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Microbiological+transformation+of+enrofloxacin+by+the+fungus+Mucor+ramannianus&rft.au=Parshikov%2C+IA%3BFreeman%2C+J+P%3BLay%2C+JO+Jr%3BBeger%2C+R+D%3BWilliams%2C+A+J%3BSutherland%2C+J+B&rft.aulast=Parshikov&rft.aufirst=IA&rft.date=2000-06-01&rft.volume=66&rft.issue=6&rft.spage=2664&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.6.2664-2667.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mucor ramannianus; Antifungal agents; quinolines; Fluoroquinolones; Veterinary medicine DO - http://dx.doi.org/10.1128/AEM.66.6.2664-2667.2000 ER - TY - JOUR T1 - Assessment of perceived traumatic injury hazards during drywall taping and sanding AN - 17541639; 4727353 AB - The objective of this study was to identify the drywall finishing tasks which are directly perceived as hazardous by workers. A questionnaire survey was conducted to evaluate workers' perceived injury hazards (physical stress, fall potential, and struck by/against an object) for six finishing tasks (4 taping and 2 sanding tasks) and three items of elevated support equipment. Thirty experienced drywall finishers participated in this study. The ratings of perceived physical stress and fall potential varied significantly among the six tasks (both p values < 0.05). Subjects perceived greater physical stress for the two drywall sanding tasks than the four taping tasks. Sanding skimmed drywall without the use of pole sanders, in particular sanding ceiling joints, nails, and corners was rated most stressful. Wrists/hands and shoulders were identified as the most affected body part subject to physical stress during drywall taping and sanding. Tasks performed with the use of stilts were rated as having greater fall potential than those without using stilts. The activity of putting on stilts and getting up on them was most likely to cause loss of balance. Results from this study provide information directly from experienced workers to help identify hazardous tasks and activities associated with drywall finishing. The findings will assist in focusing future research efforts on the most hazardous tasks and activities of drywall finishing. JF - International Journal of Industrial Ergonomics AU - Pan, C S AU - Chiou, S S AU - Hsiao, H AU - Becker, P AU - Akladios, M AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 621 EP - 631 VL - 25 IS - 6 SN - 0169-8141, 0169-8141 KW - drywall finishing KW - falls KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Injuries KW - Occupational safety KW - Stress KW - Hazards KW - Perception KW - Construction industry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17541639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Assessment+of+perceived+traumatic+injury+hazards+during+drywall+taping+and+sanding&rft.au=Pan%2C+C+S%3BChiou%2C+S+S%3BHsiao%2C+H%3BBecker%2C+P%3BAkladios%2C+M&rft.aulast=Pan&rft.aufirst=C&rft.date=2000-06-01&rft.volume=25&rft.issue=6&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2FS0169-8141%2899%2900049-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hazards; Perception; Occupational safety; Stress; Injuries; Construction industry; Risk assessment DO - http://dx.doi.org/10.1016/S0169-8141(99)00049-9 ER - TY - JOUR T1 - Direct enumeration of Escherichia coli and enteric bacteria in water, beverages and sprouts by 16S rRNA in situ hybridization AN - 17522707; 4710444 AB - A fluorescent oligonucleotide probe complementary to a published 16S ribosomal RNA sequence of Escherichia coli was used for in situ hybridization on membrane filters for direct enumeration of cells. The direct epifluorescent filter technique (DEFT) was modified by performing a 2-h oligonucleotide hybridization on intact cells collected on a membrane filter surface ('oligo-DEFT'), instead of the traditional acridine orange staining. The filter was examined by epifluorescence microscopy, and digital image analysis was used for the cell enumeration. Oligo-DEFT counts were linear over the range of 10 super(3)-10 super(6)cells ml super(-1)and correlated with DEFT counts (r=0.99). The oligo-DEFT detection limit was approximately 1 cell ml super(-1). Oligo-DEFT counts correlated with standard coliform counts by membrane filtration or plating on selective media for analysis of water and beverages artificially inoculated with E. coli. Heat inactivation of the cells did not destroy their reactivity in the oligo-DEFT. Natural coliform populations in aquarium water were countable in the oligo-DEFT after a 90-min incubation of the filter on nutrient agar before the hybridization step, which allowed the dormant cells to increase their rRNA content. Natural populations in bean sprouts were countable directly, without having to perform the incubation before hybridization. JF - Food Microbiology AU - Tortorello, M L AU - Reineke, K F AD - US Food and Drug Administration, Illinois Institute of Technology, 6502 South Archer Road, Summit-Argo, 60501, Illinois, USA, mlt@cfsan.fda.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 305 EP - 313 PB - Academic Press VL - 17 IS - 3 SN - 0740-0020, 0740-0020 KW - enumeration KW - oligonucleotides KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Beverages KW - Gastrointestinal tract diseases KW - Escherichia coli KW - Food contamination KW - rRNA 16S KW - Hybridization analysis KW - A 01017:Human foods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17522707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Direct+enumeration+of+Escherichia+coli+and+enteric+bacteria+in+water%2C+beverages+and+sprouts+by+16S+rRNA+in+situ+hybridization&rft.au=Tortorello%2C+M+L%3BReineke%2C+K+F&rft.aulast=Tortorello&rft.aufirst=M&rft.date=2000-06-01&rft.volume=17&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1006%2Ffmic.1999.0317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Food contamination; Beverages; Hybridization analysis; rRNA 16S; Gastrointestinal tract diseases DO - http://dx.doi.org/10.1006/fmic.1999.0317 ER - TY - JOUR T1 - Weighted p-Value Adjustments for Animal Carcinogenicity Trend Test AN - 1367482006; 15992347 AB - Summary. A typical animal carcinogenicity experiment routinely analyzes approximately 10-30 tumor sites. Comparisons of tumor responses between dosed and control groups and dose-related trend tests are often evaluated for each individual tumor site/type separately. p-Value adjustment approaches have been proposed for controlling the overall Type I error rate or familywise error rate (FWE). However, these adjustments often result in reducing the power to detect a dose effect. This paper proposes using weighted adjustments by assuming that each tumor can be classified as either class A or class B based on prior considerations. The tumors in class A, which are considered as more critical endpoints, are given less adjustment. Two weighted methods of adjustments are presented, the weighted p adjustment and weighted alpha adjustment. A Monte Carlo simulation shows that both weighted adjustments control the FWE well. Furthermore, the power increases if a treatment-dependent tumor is analyzed as in class A tumors and the power decreases if it is analyzed as in class B tumors. A data set from a National Toxicology Program (NTP) 2-year animal carcinogenicity experiment with 13 tumor types/sites observed in male mice was analyzed using the proposed methods. The modified poly-3 test was used to test for increased carcinogenicity since it has been adopted by the NTP as a standard test for a dose-related trend. The unweighted adjustment analysis concluded that there was no statistically significant dose-related trend. Using the Food and Drug Administration classification scheme for the weighted adjustment analyses, two rare tumors (with background rates of 1% or less) were analyzed as class A tumors and 11 common tumors (with background rates higher than 1%) as class B. Both weighted analyses showed a significant dose-related trend for one rare tumor. JF - Biometrics AU - Chen, James J AU - Lin, Karl K AU - Huque, Mohammad AU - Arani, Ramin B AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, U.S.A. Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 586 EP - 592 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 56 IS - 2 SN - 0006-341X, 0006-341X KW - Toxicology Abstracts KW - Biometrics KW - Tumors KW - X:24300 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1367482006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Weighted+p-Value+Adjustments+for+Animal+Carcinogenicity+Trend+Test&rft.au=Chen%2C+James+J%3BLin%2C+Karl+K%3BHuque%2C+Mohammad%3BArani%2C+Ramin+B&rft.aulast=Chen&rft.aufirst=James&rft.date=2000-06-01&rft.volume=56&rft.issue=2&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.0006-341X.2000.00586.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Tumors DO - http://dx.doi.org/10.1111/j.0006-341X.2000.00586.x ER - TY - JOUR T1 - Improving HIV/AIDS services through palliative care: An HRSA perspective AN - 1038598347; 17058631 AB - There has been a dramatic shift of the human immunodeficiency virus/acquired immunodeficiency syndrom (HIV/AIDS) epidemic into poor, marginalized, and minority communities in the US. At the same time, the availability of new highly active antiretroviral treatments has made it possible for a large number of individuals to live for a much longer time with their disease. A net result is that the US is faced with an increasing number of people who are living with HIV/AIDS and are dependent on publicly supported health care services. In this paper, we review the palliative care efforts of the federal agency, the Health Resources and Services Administration (HRSA), responsible for providing Ryan White CARE Act HIV/AIDS care to medically underserved populations. In addition to supporting traditional hospice care, HRSA's HIV/AIDS Bureau has begun a series of initiatives that apply a broader concept of palliative care to its HIV programs in hospital-and community-based settings. Our interest is not to substitute palliation for access to new HIV therapies, such as highly active antiretroviral treatments, but to ensure that our health delivery systems attend to the alleviation of symptoms and suffering along with the provision of antiretroviral and other necessary treatments. HRSA's HIV/AIDS Bureau is organizing a broader provision of palliative care for its clients and actively contributing to improving care for the disenfrachised internationally. JF - Journal of Urban Health AU - O'Neill, Joseph F AU - Marconi, Katherine AU - Surapruik, Ann AU - Blum, Nancy AD - HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishert Lane, Room 7A-07, 20857, Rockville, MD Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 244 EP - 254 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 77 IS - 2 SN - 1099-3460, 1099-3460 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Acquired immune deficiency syndrome KW - Epidemics KW - Health care KW - Antiviral agents KW - Human immunodeficiency virus KW - Community involvement KW - Reviews KW - antiretroviral agents KW - Palliation KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038598347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urban+Health&rft.atitle=Improving+HIV%2FAIDS+services+through+palliative+care%3A+An+HRSA+perspective&rft.au=O%27Neill%2C+Joseph+F%3BMarconi%2C+Katherine%3BSurapruik%2C+Ann%3BBlum%2C+Nancy&rft.aulast=O%27Neill&rft.aufirst=Joseph&rft.date=2000-06-01&rft.volume=77&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urban+Health&rft.issn=10993460&rft_id=info:doi/10.1007%2FBF02390535 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Epidemics; Antiviral agents; Reviews; Palliation; Health care; Human immunodeficiency virus; Community involvement; antiretroviral agents DO - http://dx.doi.org/10.1007/BF02390535 ER - TY - JOUR T1 - Mutational spectra for polycyclic aromatic hydrocarbons in the supF target gene. AN - 71158331; 10838135 AB - An SV40-based shuttle vector system was used to identify the types of mutational changes and the sites of mutation within the supF DNA sequence generated by the four stereoisomers of benzo[c]phenanthrene 3,4-dihydrodiol 1,2-epoxide (B[c]PhDE), by racemic mixtures of bay or fjord region dihydrodiol epoxides (DE) of 5-methylchrysene, of 5, 6-dimethylchrysene, of benzo[g]chrysene and of 7-methylbenz[a]anthracene and by two direct acting polycyclic aromatic hydrocarbon carcinogens, 7-bromomethylbenz[a]anthracene (7-BrMeBA) and 7-bromomethyl-12-methylbenz[a]anthracene (7-BrMe-12-MeBA). The results of these studies demonstrated that the predominant type of mutation induced by these compounds is the base substitution. The chemical preference for reaction at deoxyadenosine (dAdo) or deoxyguanosine (dGuo) residues in DNA, which is in general correlated with the spatial structure (planar or non-planar) of the reactive polycyclic aromatic hydrocarbon, is reflected in the preference for mutation at A&z.ccirf;T or G&z.ccirf;C pairs. In addition, if the ability to react with DNA in vivo is taken into account, the relative mutagenic potencies of the B[c]PhDE stereoisomers are consistent with the higher tumorigenic activity associated with non-planar polycyclic aromatic hydrocarbons and their extensive reaction with dAdo residues in DNA. Comparison of the types of mutations generated by polycyclic aromatic hydrocarbons and other bulky carcinogens in this shuttle vector system suggests that all bulky lesions may be processed by a similar mechanism related to that involved in replication past apurinic sites. However, inspection of the distribution of mutations over the target gene induced by the different compounds demonstrated that individual polycyclic aromatic hydrocarbons induce unique patterns of mutational hotspots within the target gene. A polymerase arrest assay was used to determine the sequence specificity of the interaction of reactive polycyclic aromatic hydrocarbons with the shuttle vector DNA. The results of these assays revealed a divergence between mutational hotspots and polymerase arrest sites for all compounds investigated, i.e., sites of mutational hotspots do not correspond to sites where high levels of adduct formation occur, and suggested that some association between specific adducts and sequence context may be required to constitute a premutagenic lesion. A site-specific mutagenesis system employing a single-stranded vector (M13mp7L2) was used to investigate the mutational events a single benzo[a]pyrene or benzo[c]phenanthrene dihydrodiol epoxide-DNA adduct elicits within specific sequence contexts. These studies showed that sequence context can cause striking differences in mutagenic frequencies for given adducts. In addition, these sequence context effects do not originate only from nucleotides immediately adjacent to the adduct, but are also modulated by more distal nucleotides. The implications of these results for mechanisms of polycyclic aromatic hydrocarbon-induced mutagenesis and carcinogenesis are discussed. JF - Mutation research AU - Bigger, C A AU - Pontén, I AU - Page, J E AU - Dipple, A AD - Chemistry of Carcinogenesis Laboratory, Basic Research Program, Advanced BioScience Laboratories, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702, USA. biggera@cder.fda.gov Y1 - 2000/05/30/ PY - 2000 DA - 2000 May 30 SP - 75 EP - 93 VL - 450 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Polycyclic Aromatic Hydrocarbons KW - 0 KW - supF tRNA KW - DNA KW - 9007-49-2 KW - RNA, Transfer KW - 9014-25-9 KW - Index Medicus KW - Animals KW - Base Sequence KW - Humans KW - Genetic Vectors KW - DNA -- genetics KW - Point Mutation KW - Molecular Sequence Data KW - Sequence Deletion KW - DNA -- drug effects KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - RNA, Transfer -- genetics KW - Polycyclic Aromatic Hydrocarbons -- chemistry KW - Mutation KW - Genes, Suppressor -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71158331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutational+spectra+for+polycyclic+aromatic+hydrocarbons+in+the+supF+target+gene.&rft.au=Bigger%2C+C+A%3BPont%C3%A9n%2C+I%3BPage%2C+J+E%3BDipple%2C+A&rft.aulast=Bigger&rft.aufirst=C&rft.date=2000-05-30&rft.volume=450&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-27 N1 - Date created - 2000-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of different promoters on immune responses elicited by HIV-1 gag/env multigenic DNA vaccine in Macaca mulatta and Macaca nemestrina AN - 17535185; 4723059 AB - pCMV-NL sub( Delta pol) and pAKV-NL sub( Delta pol) expressed human immunodeficiency virus type 1 (HIV-1) gag and env under the regulation of the human cytomegalovirus (CMV) immediate-early (IE) promoter/enhancer and the endogenous AKV murine leukemia viral long terminal repeat (LTR), respectively. Analysis of the immune responses elicited by direct DNA injection of pCMV-NL sub( Delta pol) and pAKV-NL sub( Delta pol) in macaques indicated that generation of the humoral and T-cell proliferative responses correlated directly with the promoter strength of the vaccine DNAs. In Macaca mulatta, pCMV-NL sub( Delta pol) generated stronger humoral responses and T-cell proliferative responses to Gag and Env using less DNA and fewer number of injections than pAKV-NL sub( Delta pol). Similarly, in Macaca nemestrina pCMV-NL sub( Delta pol) elicited high humoral responses, which persisted long-term and were boostable. Injection of large amounts of pAKV-NL sub( Delta pol), in general, failed to produce antibody levels comparable to pCMV-NL sub( Delta pol). However, injection of a control animal with large amounts of vector DNA produced a generalized enzyme-linked immunosorbent assay (ELISA) reactivity to HIV-1. The results indicated that generation of high immune responses to HIV-1 cannot be achieved by increasing the vaccine DNA dose and may require high protein expression from the DNA by including a strong promoter or by the use of other boosting agents. Furthermore, safety concerns may arise with increasing the DNA dose that could need additional investigation. JF - Vaccine AU - Galvin, T A AU - Muller, J AU - Khan, A S AD - 1401 Rockville Pike, HFM-454, Rockville, MD 20852-1448, USA, khan@cber.fda.gov Y1 - 2000/05/22/ PY - 2000 DA - 2000 May 22 SP - 2566 EP - 2583 VL - 18 IS - 23 SN - 0264-410X, 0264-410X KW - Rhesus monkey KW - HIV-1 KW - immunology KW - Macaca mulatta KW - Macaca nemestrina KW - env gene KW - gag gene KW - human immunodeficiency virus 1 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Promoters KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - Immune response KW - Vaccines KW - F 06807:Active immunization KW - V 22003:AIDS: Immunological aspects KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17535185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Effect+of+different+promoters+on+immune+responses+elicited+by+HIV-1+gag%2Fenv+multigenic+DNA+vaccine+in+Macaca+mulatta+and+Macaca+nemestrina&rft.au=Galvin%2C+T+A%3BMuller%2C+J%3BKhan%2C+A+S&rft.aulast=Galvin&rft.aufirst=T&rft.date=2000-05-22&rft.volume=18&rft.issue=23&rft.spage=2566&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Macaca nemestrina; Macaca mulatta; Human immunodeficiency virus 1; DNA vaccines; Vaccines; Promoters; Immune response ER - TY - JOUR T1 - Correlation between autopsy findings for chronic obstructive airways disease and in-life disability in South African gold miners AN - 17535447; 4721985 JF - International Archives of Occupational and Environmental Health AU - Hnizdo, E AU - Murray, J AU - Davison, A AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2800 Morgantown, WV 26505-2845, USA, EXH6@cdc.gov Y1 - 2000/05/19/ PY - 2000 DA - 2000 May 19 SP - 235 EP - 244 PB - Springer-Verlag VL - 73 IS - 4 SN - 0340-0131, 0340-0131 KW - man KW - South Africa KW - Toxicology Abstracts KW - Respiratory tract diseases KW - Autopsy KW - Lung KW - Occupational hazards KW - Gold KW - Mines KW - Chronic obstructive pulmonary disease KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17535447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Correlation+between+autopsy+findings+for+chronic+obstructive+airways+disease+and+in-life+disability+in+South+African+gold+miners&rft.au=Hnizdo%2C+E%3BMurray%2C+J%3BDavison%2C+A&rft.aulast=Hnizdo&rft.aufirst=E&rft.date=2000-05-19&rft.volume=73&rft.issue=4&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Gold; Occupational hazards; Autopsy; Chronic obstructive pulmonary disease; Mines; Respiratory tract diseases; Lung ER - TY - JOUR T1 - Quantitating silver-stained neurodegeneration: the neurotoxicity of trimethlytin (TMT) in aged rats. AN - 71166002; 10837873 AB - This report describes the development of a histoanalytical procedure to measure the degree of neurodegeneration produced by the organometal toxicant trimethyltin (TMT). Based on a previous, non-quantitated experiment we hypothesized that the same dose of TMT would produce greater damage in animals of increasing age. Male rats aged 6, 12, 18, or 24 months at the time of dosing were given either 4.5 mg/kg TMT or saline (i.p.). One month after dosing, rats were perfused and their brains removed and processed to selectively silver-impregnate degenerating cell bodies as well as axon terminals and dendrites. Neurodegeneration was most prominent in the hippocampi (especially CA1 stratum radiatum) of TMT-treated rats, but not in the controls. Computer-assisted counting of the silver grains marking damage indicated greater neurotoxicity from the same dose of TMT when given to the older animals. Thus the grain density in the 6-month-old TMT-treated rats was not significantly elevated from the 6-month-old controls (P>0.10). The 12-month-old TMT-treated rats had significantly increased grain densities compared to their controls (P<0.05), but still larger increases of grain counts were observed in the 18- and 24-month-old rats (both P-values<0.01). Our findings with TMT are similar to previous, but nonquantitative, reports that the neurotoxic effects of kainic acid and methionine sulfoximine were also greater in older rats. An increased sensitivity to neurotoxicants might help explain the apparently spontaneous degeneration of cortical neurons in aging and in the neurological diseases of old age. The method we report here for quantitation of silver grains marking neurodegeneration should be adaptable to a wide range of histologically-based neurotoxicology investigations. JF - Journal of neuroscience methods AU - Scallet, A C AU - Pothuluri, N AU - Rountree, R L AU - Matthews, J C AD - HFT-132, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Drive, 72079-9502, Jefferson, AR, USA. ascallet@nctr.fda.gov Y1 - 2000/05/15/ PY - 2000 DA - 2000 May 15 SP - 69 EP - 76 VL - 98 IS - 1 SN - 0165-0270, 0165-0270 KW - Trimethyltin Compounds KW - 0 KW - trimethyltin KW - 1631-73-8 KW - Index Medicus KW - Rats KW - Image Cytometry KW - Animals KW - Rats, Inbred F344 KW - Cell Count KW - Hippocampus -- pathology KW - Male KW - Nerve Degeneration -- pathology KW - Aging -- pathology KW - Silver Staining -- methods KW - Trimethyltin Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71166002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+methods&rft.atitle=Quantitating+silver-stained+neurodegeneration%3A+the+neurotoxicity+of+trimethlytin+%28TMT%29+in+aged+rats.&rft.au=Scallet%2C+A+C%3BPothuluri%2C+N%3BRountree%2C+R+L%3BMatthews%2C+J+C&rft.aulast=Scallet&rft.aufirst=A&rft.date=2000-05-15&rft.volume=98&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+methods&rft.issn=01650270&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-15 N1 - Date created - 2000-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conversion of interleukin-13 into a high affinity agonist by a single amino acid substitution. AN - 71096699; 10799519 AB - We created a novel mutated form of human interleukin-13 (IL-13) in which a positively charged arginine (R) at position 112 was substituted to a negatively charged aspartic acid (D). This mutant, termed IL-13R112D, was expressed in Escherichia coli and purified to near homogeneity. IL-13R112D was found to be a potent IL-13 agonist with 5-10-fold improved binding affinity to IL-13 receptors compared with wild-type IL-13 (wtIL-13). The conclusion of IL-13 agonist activity was drawn on the basis of approximately 10-fold improved activity over wtIL-13 in several assays: (a) inhibition of CD14 expression in primary monocytes; (b) proliferation of TF-1 and B9 cell lines; and (c) activation of STAT6 in Epstein-Barr virus-immortalized B cells, primary monocytes, and THP-1 monocytic cell line. Furthermore, mutant IL-13R112D neutralized the cytotoxic activity of a chimeric fusion protein composed of wtIL-13 and a Pseudomonas exotoxin A (IL-13-PE38) approximately 10 times better than wtIL-13. Based on these results, it was concluded that IL-13R112D interacts with much stronger affinity than wtIL-13 on all cell types tested and that Arg-112 plays an important role in the interaction with its receptors (IL-13R). Thus, these results suggest that IL-13R112D may be a useful ligand for the study of IL-13 interaction with its receptors or, alternatively, in designing specific targeted agents for IL-13R-positive malignancies. JF - The Journal of biological chemistry AU - Oshima, Y AU - Joshi, B H AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2000/05/12/ PY - 2000 DA - 2000 May 12 SP - 14375 EP - 14380 VL - 275 IS - 19 SN - 0021-9258, 0021-9258 KW - Antigens, CD14 KW - 0 KW - Interleukin-13 KW - STAT6 Transcription Factor KW - STAT6 protein, human KW - Trans-Activators KW - Arginine KW - 94ZLA3W45F KW - Index Medicus KW - Trans-Activators -- metabolism KW - Animals KW - Arginine -- metabolism KW - Arginine -- chemistry KW - Humans KW - Amino Acid Sequence KW - Radioligand Assay KW - Antigens, CD14 -- immunology KW - Mutagenesis, Site-Directed KW - Tumor Cells, Cultured KW - Down-Regulation KW - Monocytes -- immunology KW - Molecular Sequence Data KW - Bone Marrow Cells -- cytology KW - Sequence Homology, Amino Acid KW - Amino Acid Substitution KW - Cell Division KW - Interleukin-13 -- chemistry KW - Interleukin-13 -- metabolism KW - Interleukin-13 -- agonists KW - Interleukin-13 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71096699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Conversion+of+interleukin-13+into+a+high+affinity+agonist+by+a+single+amino+acid+substitution.&rft.au=Oshima%2C+Y%3BJoshi%2C+B+H%3BPuri%2C+R+K&rft.aulast=Oshima&rft.aufirst=Y&rft.date=2000-05-12&rft.volume=275&rft.issue=19&rft.spage=14375&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-08 N1 - Date created - 2000-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of mouse strains using the local lymph node assay. AN - 71120711; 10814854 AB - The local lymph node assay (LLNA), as recommended by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), only allows for the use of CBA mice. The objective of these studies was to begin to assess the response of chemical sensitizers in the LLNA across six strains of female mice (C57BL/6, SJL/J, BALB/c, B6C3F1, DBA/2 and CBA). The moderate sensitizer alpha-hexylcinnamaldehyde (HCA) was chosen as the test chemical, while toluene diisocyanate (TDI) and 2,4-dinitrofluorobenzene (DNFB) were evaluated at single concentrations as positive controls. Draining lymph node cell proliferation following acetone exposure varied across strains. SJL mice had a significantly higher degree of proliferation with 2111 d.p.m./2 nodes. The remaining five strains demonstrated responses which ranged from 345 to 887 dpm/2 nodes. DBA/2, B6C3F1, BALB/c and CBA mice had essentially equal levels of lymph node proliferation following exposure to the three chemicals. While C57BL/6 mice gave similar results as CBA mice following DNFB and HCA administration, the LLNA response to TDI was considerably lower. SJL mice provided low stimulation indexes (SI) values for all three chemicals evaluated. Regardless of the level of LLNA response, all six mouse strains identified the sensitization potential of HCA, TDI or DNFB. Based on these studies, DBA/2, B6C3F1 and BALB/c mice are good choices for continued evaluation as additional mouse strains for use in the LLNA. JF - Toxicology AU - Woolhiser, M R AU - Munson, A E AU - Meade, B J AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. Y1 - 2000/05/05/ PY - 2000 DA - 2000 May 05 SP - 221 EP - 227 VL - 146 IS - 2-3 SN - 0300-483X, 0300-483X KW - hexyl cinnamic aldehyde KW - 101-86-0 KW - Toluene 2,4-Diisocyanate KW - 17X7AFZ1GH KW - Acrolein KW - 7864XYD3JJ KW - Dinitrofluorobenzene KW - D241E059U6 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Stimulation, Chemical KW - Mice, Inbred Strains KW - Animals KW - Dinitrofluorobenzene -- toxicity KW - Acrolein -- analogs & derivatives KW - Toluene 2,4-Diisocyanate -- toxicity KW - Mice KW - Dermatitis, Allergic Contact -- pathology KW - Species Specificity KW - Female KW - Acrolein -- toxicity KW - Lymph Nodes -- drug effects KW - Lymph Nodes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71120711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Comparison+of+mouse+strains+using+the+local+lymph+node+assay.&rft.au=Woolhiser%2C+M+R%3BMunson%2C+A+E%3BMeade%2C+B+J&rft.aulast=Woolhiser&rft.aufirst=M&rft.date=2000-05-05&rft.volume=146&rft.issue=2-3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-17 N1 - Date created - 2000-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain. AN - 71088173; 10793188 AB - The excitatory amino acid glutamate has been implicated in the neurodegeneration associated with several different central nervous system diseases. Treatment with kainic acid (KA), a glutamate analog known to activate the AMPA/KA subtype of glutamate receptor, has been widely used as a model of epilepsy. Long term temporal studies of its neuropathological effects, however, are lacking. In this study, two techniques were used to directly visualize and characterize the neuropathology that occurred over a 2-month period following KA-induced status epilepticus in adult female Sprague-Dawley rats. Post-injection survival was 2, 4, 8 h, 2 days, 2 weeks, or 2 months. Labeling with Fluoro-Jade B (FJB), a fluorescent green dye that labels the cell body, dendrites, axons and axon terminals of degenerating neurons, was observed within the cortex, hippocampus, thalamus, basal ganglia, and amygdala by 4 h post-treatment. The highest level of labeling was seen in the piriform cortex, hippocampus, and thalamus. Myelin changes in the rat forebrain following KA treatment were also examined using the myelin-specific Black-Gold (BG) stain. Varicose myelinated fibers were observed in the same regions as FJB positive neurons, although these changes were evident by the 2-h survival time-point. Both stains showed a temporal progression of brain damage throughout the affected areas. By 2 months post-treatment, few degenerating neurons could be detected and abnormal myelin was absent in most regions. As myelin changes can be seen prior to neuronal degeneration, and oligodendrocytes express functional AMPA/kainate-type glutamate receptors, the neurodegeneration and myelin pathologies may occur as independent events. Thus, researchers should consider the temporal and multiple effects of kainic acid to optimize conditions for their endpoint of interest when designing experiments. JF - Brain research AU - Hopkins, K J AU - Wang, G AU - Schmued, L C AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, USA. khopkins@nctr.fda.gov Y1 - 2000/05/02/ PY - 2000 DA - 2000 May 02 SP - 69 EP - 80 VL - 864 IS - 1 SN - 0006-8993, 0006-8993 KW - Black-Gold KW - 0 KW - Coloring Agents KW - Excitatory Amino Acid Agonists KW - Fluorescent Dyes KW - Neurotoxins KW - Phosphates KW - Receptors, AMPA KW - Receptors, Kainic Acid KW - Glutamic Acid KW - 3KX376GY7L KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Animals KW - Receptors, AMPA -- drug effects KW - Receptors, Kainic Acid -- metabolism KW - Hypothalamus -- pathology KW - Hypothalamus -- physiopathology KW - Thalamus -- pathology KW - Disease Models, Animal KW - Amygdala -- pathology KW - Basal Ganglia -- pathology KW - Rats KW - Epilepsy -- pathology KW - Status Epilepticus -- chemically induced KW - Parietal Lobe -- pathology KW - Basal Ganglia -- physiopathology KW - Hippocampus -- physiopathology KW - Thalamus -- physiopathology KW - Olfactory Pathways -- pathology KW - Time Factors KW - Epilepsy -- physiopathology KW - Glutamic Acid -- metabolism KW - Neurotoxins -- metabolism KW - Olfactory Pathways -- physiopathology KW - Status Epilepticus -- physiopathology KW - Status Epilepticus -- pathology KW - Receptors, AMPA -- metabolism KW - Amygdala -- physiopathology KW - Rats, Sprague-Dawley KW - Receptors, Kainic Acid -- drug effects KW - Hippocampus -- pathology KW - Parietal Lobe -- physiopathology KW - Female KW - Myelin Sheath -- pathology KW - Denervation -- adverse effects KW - Neurons -- drug effects KW - Nerve Degeneration -- physiopathology KW - Nerve Degeneration -- pathology KW - Myelin Sheath -- drug effects KW - Prosencephalon -- drug effects KW - Prosencephalon -- pathology KW - Nerve Degeneration -- chemically induced KW - Prosencephalon -- physiopathology KW - Excitatory Amino Acid Agonists -- toxicity KW - Kainic Acid -- toxicity KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71088173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Temporal+progression+of+kainic+acid+induced+neuronal+and+myelin+degeneration+in+the+rat+forebrain.&rft.au=Hopkins%2C+K+J%3BWang%2C+G%3BSchmued%2C+L+C&rft.aulast=Hopkins&rft.aufirst=K&rft.date=2000-05-02&rft.volume=864&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-11 N1 - Date created - 2000-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Parents Matter: Tips for Raising Teenagers. AN - 62329362; ED450324 AB - It is easy for parents to feel that they have lost their influence over their children once children reach adolescence. Several organizations with different focuses but with the same goal of helping parents raise their teenagers banded together to develop this publication. Their message is that parents can do many things to foster their children's talents and skills while guiding them towards healthy development. Several ideas for parents are detailed that can help make a difference in the lives of their children. Some of the ideas include: (1) spend time with the children; (2) help teens gain a sense of self-confidence; (3) work with teens to set goals; (4) let teens know that education is valued highly; (5) stay involved in their children's schools; and (6) know where the children are and what they are doing at all times. A list of resources is included. (JDM) Y1 - 2000/05/02/ PY - 2000 DA - 2000 May 02 SP - 17 KW - ERIC, Resources in Education (RIE) KW - Parents KW - At Risk Persons KW - Parent Child Relationship KW - Child Rearing KW - Parent Role KW - Parent Participation KW - Family Relationship KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62329362?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Prepared for the White House Conference on Teenage N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - US FDA QUOTATION_MARKRedbook IIQUOTATION_MARK Immunotoxicity Testing Guidelines and Research in Immunotoxicity Evaluations of Food Chemicals and New Food Proteins AN - 762269507; 13646068 AB - The rapid advances in the field of immunology and an understanding of the potential adverse effects of xenobiotics on the immune system have resulted in the development of a discipline in toxicology now referred to as immunotoxicology. This discipline has evolved steadily over the last 2 decades as a result of research in the national and international communities. Various US, European, and Japanese regulatory agencies have recognized a need to promulgate testing guidelines for immunotoxicity in support of the approval process involving toxicological testing. The US Food and Drug Administration QUOTATION_MARKRedbook IIQUOTATION_MARK guidelines and some of the research conducted in support of the concepts and testing strategies are presented here. Concerns raised with regard to these guidelines are included, as are on-going initiatives in development of experimental approaches for assessing allergic potential and/or hypersensitivity responses to new foods and food constituents. JF - Toxicologic Pathology AU - Hinton, Dennis M AD - Biochemical and Analytical Toxicology Branch, Division of Toxicological Studies, Office of Special Research Skills, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 467 EP - 478 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 28 IS - 3 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts; Immunology Abstracts KW - Food hypersensitivity KW - Immune response KW - Immune system KW - Immunotoxicity KW - Side effects KW - Xenobiotics KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762269507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=US+FDA+QUOTATION_MARKRedbook+IIQUOTATION_MARK+Immunotoxicity+Testing+Guidelines+and+Research+in+Immunotoxicity+Evaluations+of+Food+Chemicals+and+New+Food+Proteins&rft.au=Hinton%2C+Dennis+M&rft.aulast=Hinton&rft.aufirst=Dennis&rft.date=2000-05-01&rft.volume=28&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F019262330002800318 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 39 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Immunotoxicity; Food hypersensitivity; Immune system; Xenobiotics; Immune response; Side effects DO - http://dx.doi.org/10.1177/019262330002800318 ER - TY - JOUR T1 - Food safety implication: certain antibiotics may rapidly contaminate egg albumen during the process of its formation. AN - 71244229; 10890213 AB - 1. Egg white formation occurs in 3 phases: synthesis and storage of albumen proteins prior to ovulation, secretion of proteins during passage of the ovum down the reproductive tract (preplumping) and addition of water (plumping phase). 2. This study was to determine if oxytetracycline would transfer into egg albumen during the latter 2 phases of albumen formation. 3. In 2 experiments 48 hens were injected with either 400 mg/kg oxytetracycline or physiological saline. Hens were dosed at 0.5 h (preplumping phase) or 5.5 h (plumping phase) after oviposition. 4. Five hours following injections, hens were euthanised and albumen was collected from the reproductive tract. 5. Oxytetracycline transferred into albumen during both phases of albumen formation. Concentrations (ppm) were greater in the preplump vs plump phase (3.2 vs 1.8 in experiment 1; or 2.8 vs 1.6 in experiment 2. However, when differences in albumen weights were accounted for, total microg transfer did not differ between the 2 phases. 6. Drugs may transfer into egg whites during the latter phases of formation prior to oviposition. Therefore, poultry producers or veterinary practitioners dosing laying hens must consider that egg whites contained in the 1st egg laid after dosing may contain drug residues. JF - British poultry science AU - Donoghue, D J AU - Hairston, H AD - Center for Veterinary Medicine, Food and Drug Administration, Laurel, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 174 EP - 177 VL - 41 IS - 2 SN - 0007-1668, 0007-1668 KW - Anti-Bacterial Agents KW - 0 KW - Ovalbumin KW - 9006-59-1 KW - Oxytetracycline KW - X20I9EN955 KW - Index Medicus KW - Food Contamination -- prevention & control KW - Animals KW - Linear Models KW - Least-Squares Analysis KW - Bacillus cereus -- drug effects KW - Oviposition KW - Female KW - Chickens -- physiology KW - Egg White KW - Drug Residues -- pharmacokinetics KW - Drug Residues -- analysis KW - Anti-Bacterial Agents -- analysis KW - Oxytetracycline -- pharmacokinetics KW - Oxytetracycline -- administration & dosage KW - Anti-Bacterial Agents -- administration & dosage KW - Anti-Bacterial Agents -- pharmacokinetics KW - Oxytetracycline -- analysis KW - Ovalbumin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71244229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+poultry+science&rft.atitle=Food+safety+implication%3A+certain+antibiotics+may+rapidly+contaminate+egg+albumen+during+the+process+of+its+formation.&rft.au=Donoghue%2C+D+J%3BHairston%2C+H&rft.aulast=Donoghue&rft.aufirst=D&rft.date=2000-05-01&rft.volume=41&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=British+poultry+science&rft.issn=00071668&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-03 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal exposure to trichloroethylene in drinking water and birth-weight outcomes. AN - 71235939; 10908102 AB - An ecological epidemiological study was conducted with data obtained from an environmental dose-reconstruction study and the Arizona Birth Information Tapes. Before 1981, a portion of the city of Tucson water-distribution system was contaminated with trichloroethylene (i.e., 35 wk and < 46 wk). JF - Archives of environmental health AU - Rodenbeck, S E AU - Sanderson, L M AU - Rene, A AD - Division of Health Assessment and Consultation Agency for Toxic Substances and Disease Registry, Public Health Service, US Department of Health and Human Services, Fort Worth, Texas, USA. PY - 2000 SP - 188 EP - 194 VL - 55 IS - 3 SN - 0003-9896, 0003-9896 KW - Solvents KW - 0 KW - Water Pollutants, Chemical KW - Trichloroethylene KW - 290YE8AR51 KW - Abridged Index Medicus KW - Index Medicus KW - Medical Records Systems, Computerized KW - Logistic Models KW - Epidemiologic Methods KW - Humans KW - Arizona KW - Water Supply KW - Infant, Newborn KW - Female KW - Maternal Exposure -- adverse effects KW - Infant, Very Low Birth Weight KW - Water Pollutants, Chemical -- adverse effects KW - Trichloroethylene -- adverse effects KW - Solvents -- adverse effects KW - Birth Weight -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71235939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Maternal+exposure+to+trichloroethylene+in+drinking+water+and+birth-weight+outcomes.&rft.au=Rodenbeck%2C+S+E%3BSanderson%2C+L+M%3BRene%2C+A&rft.aulast=Rodenbeck&rft.aufirst=S&rft.date=2000-05-01&rft.volume=55&rft.issue=3&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-03 N1 - Date created - 2000-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen. AN - 71219839; 10875686 AB - 1. The effect of PEITC on the expression of hepatic glutathione S-transferases (GST) and the glutathione (GSH) conjugation has been investigated in the Sprague-Dawley rat, and it has been determined whether hepatotoxicity of acetaminophen (AA) could be inhibited through the induction of GST expression in mouse. 2. The hepatic GST activity and protein levels of alpha class (Ya, Yc) and mu class (Yb1, Yb2) of GST were elevated in a dose-dependent manner after treatment with PEITC (0, 3.16, 10, 31.6, 100 and 200 mg/kg, p.o., 3 days). The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg. The hepatic GSH content was significantly increased to 200% of control at dose of 200 mg/kg PEITC. 3. Pretreatment with 100 mg/kg PEITC significantly enhanced the biliary excretion of glutathione conjugate of AA 2-fold, whereas treatment with 200 mg/kg did not affect it. 4. In mouse, PEITC (100 and 200 mg/kg, 3 days) decreased the lethality and hepatotoxicity caused by AA. 5. These results indicate that (1) the induction of GST by PEITC is presumably under transcriptional regulation, and (2) PEITC may have a protective function against AA-induced hepatotoxicity by induction effect on GST, in combination of enhancement of hepatic GSH. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Seo, K W AU - Kim, J G AU - Park, M AU - Kim, T W AU - Kim, H J AD - Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul. kwseo@kfda.go.kr Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 535 EP - 545 VL - 30 IS - 5 SN - 0049-8254, 0049-8254 KW - Carcinogens KW - 0 KW - Isothiocyanates KW - RNA, Messenger KW - Poly A KW - 24937-83-5 KW - Acetaminophen KW - 362O9ITL9D KW - phenethyl isothiocyanate KW - 6U7TFK75KV KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Mice, Inbred ICR KW - Blotting, Northern KW - Cytosol -- drug effects KW - Dose-Response Relationship, Drug KW - Bile -- metabolism KW - Mice KW - Poly A -- metabolism KW - Bile -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Male KW - Isothiocyanates -- pharmacology KW - Carcinogens -- pharmacology KW - Liver -- pathology KW - Liver -- drug effects KW - Glutathione Transferase -- biosynthesis KW - Liver -- metabolism KW - Acetaminophen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71219839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=Effects+of+phenethylisothiocyanate+on+the+expression+of+glutathione+S-transferases+and+hepatotoxicity+induced+by+acetaminophen.&rft.au=Seo%2C+K+W%3BKim%2C+J+G%3BPark%2C+M%3BKim%2C+T+W%3BKim%2C+H+J&rft.aulast=Seo&rft.aufirst=K&rft.date=2000-05-01&rft.volume=30&rft.issue=5&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=00498254&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Confirmation of patulin and 5-hydroxymethylfurfural in apple juice by gas chromatography/mass spectrometry. AN - 71204885; 10868584 AB - A gas chromatographic/mass spectrometric (GC/MS) method was developed for the confirmation of patulin and 5-hydroxymethylfurfural (HMF) extracted from apple juice. The extraction is based on the official AOAC method for liquid chromatographic analysis. Juice extracts are quickly and easily derivatized with bis(trimethylsilyl)trifluoracetamide under mild conditions, and the trimethylsilyl ethers of the analytes are stable for at least several hours. The analytes are determined by GC/MS using an electron-impact source and selected ion monitoring of characteristic ions. For both analytes, the interassay differences between base-peak ratios for samples and standards were all <7.1% (absolute). The presence of patulin was confirmed at fortification levels of about 30-400 microg/L and naturally occurring levels of about 80-400 microg/L. The presence of HMF was also confirmed at levels < or = 2 mg/L. The proposed mass spectral fragmentation pathways of the analytes are presented. JF - Journal of AOAC International AU - Rupp, H S AU - Turnipseed, S B AD - US Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA 98021, USA. PY - 2000 SP - 612 EP - 620 VL - 83 IS - 3 SN - 1060-3271, 1060-3271 KW - Mutagens KW - 0 KW - 5-hydroxymethylfurfural KW - 70ETD81LF0 KW - Patulin KW - 95X2BV4W8R KW - Furaldehyde KW - DJ1HGI319P KW - Index Medicus KW - Reproducibility of Results KW - Chromatography, Liquid KW - Furaldehyde -- analysis KW - Gas Chromatography-Mass Spectrometry -- methods KW - Beverages KW - Mutagens -- analysis KW - Furaldehyde -- analogs & derivatives KW - Food Contamination -- analysis KW - Rosales -- chemistry KW - Patulin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71204885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Confirmation+of+patulin+and+5-hydroxymethylfurfural+in+apple+juice+by+gas+chromatography%2Fmass+spectrometry.&rft.au=Rupp%2C+H+S%3BTurnipseed%2C+S+B&rft.aulast=Rupp&rft.aufirst=H&rft.date=2000-05-01&rft.volume=83&rft.issue=3&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - US FDA "Redbook II" immunotoxicity testing guidelines and research in immunotoxicity evaluations of food chemicals and new food proteins. AN - 71193557; 10862567 AB - The rapid advances in the field of immunology and an understanding of the potential adverse effects of xenobiotics on the immune system have resulted in the development of a discipline in toxicology now referred to as immunotoxicology. This discipline has evolved steadily over the last 2 decades as a result of research in the national and international communities. Various US, European, and Japanese regulatory agencies have recognized a need to promulgate testing guidelines for immunotoxicity in support of the approval process involving toxicological testing. The US Food and Drug Administration "Redbook II" guidelines and some of the research conducted in support of the concepts and testing strategies are presented here. Concerns raised with regard to these guidelines are included, as are on-going initiatives in development of experimental approaches for assessing allergic potential and/or hypersensitivity responses to new foods and food constituents. JF - Toxicologic pathology AU - Hinton, D M AD - Biochemical and Analytical Toxicology Branch, Division of Toxicological Studies, Office of Special Research Skills, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA. PY - 2000 SP - 467 EP - 478 VL - 28 IS - 3 SN - 0192-6233, 0192-6233 KW - Food Additives KW - 0 KW - Immunosuppressive Agents KW - Organophosphates KW - triphenyl phosphate KW - YZE19Z66EA KW - Index Medicus KW - United States KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - United States Food and Drug Administration KW - Organophosphates -- toxicity KW - Mice KW - Swine, Miniature KW - Female KW - Pregnancy KW - Immune System Diseases -- chemically induced KW - Immune System -- pathology KW - Immune System -- drug effects KW - Immunosuppressive Agents -- toxicity KW - Guidelines as Topic KW - Food Additives -- toxicity KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71193557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=US+FDA+%22Redbook+II%22+immunotoxicity+testing+guidelines+and+research+in+immunotoxicity+evaluations+of+food+chemicals+and+new+food+proteins.&rft.au=Hinton%2C+D+M&rft.aulast=Hinton&rft.aufirst=D&rft.date=2000-05-01&rft.volume=28&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-05 N1 - Date created - 2000-10-05 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Protecting your patient's eyes. AN - 71190149; 10855206 JF - Nursing AU - Woo, E K AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md., USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 81 VL - 30 IS - 5 SN - 0360-4039, 0360-4039 KW - Disinfectants KW - 0 KW - Nursing KW - Humans KW - Disinfectants -- adverse effects KW - Contact Lenses -- adverse effects KW - Patient Education as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71190149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Protecting+your+patient%27s+eyes.&rft.au=Woo%2C+E+K&rft.aulast=Woo&rft.aufirst=E&rft.date=2000-05-01&rft.volume=30&rft.issue=5&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=03604039&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-22 N1 - Date created - 2000-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of changes evoked by GABA (gamma-aminobutyric acid) and anoxia in [K+]o, [Cl-]o, and [Na+]o in stratum pyramidale and stratum radiatum of the guinea pig hippocampus. AN - 71164838; 10841433 AB - Ion-selective microelectrode recordings were made to assess a possible contribution of extracellular gamma-aminobutyric acid (GABA) accumulation to early responses evoked in the brain by anoxia and ischemia. Changes evoked by GABA or N2 in [K+]o, [Cl-]o, [Na+]o, and [TMA+]o were recorded in the cell body and dendritic regions of the stratum pyramidale (SP) and stratum radiatum (SR), respectively, of pyramidal neurons in CA1 of guinea pig hippocampal slices. Bath application of GABA (1-10 mM) for approximately 5 min evoked changes in [K+]o and [Cl-]o with respective EC50 levels of 3.8 and 4.1 mM in SP, and 4.7 and 5.6 mM in SR. In SP 5 mM GABA reversibly increased [K+]o and [Cl-]o and decreased [Na+]o; replacement of 95% O2 -5% CO2 by 95% N2 -5% CO2 for a similar period of time evoked changes which were for each ion in the same direction as those with GABA. In SR both GABA and N2 caused increases in [K+]o and decreases in [Cl-]o and [Na+]. The reduction of extracellular space, estimated from levels of [TMA+]o during exposures to GABA and N2, was 5-6% and insufficient to cause the observed changes in ion concentration. Ion changes induced by GABA and N2 were reversibly attenuated by the GABA(A) receptor antagonist bicuculline methiodide (BMI, 100 microM). GABA-evoked changes in [K+]o in SP and SR and [Cl-]o in SP were depressed by > or =90%, and of [Cl-]o in SR by 50%; N2-evoked changes in [K+]o in SP and SR were decreased by 70% and those of [Cl-]o by 50%. BMI blocked delta [Na+]o with both GABA and N2 by 20-30%. It is concluded that during early anoxia: (i) accumulation of GABA and activation of GABA(A) receptors may contribute to the ion changes and play a significant role, and (ii) responses in the dendritic (SR) regions are greater than and (or) differ from those in the somal (SP) layers. A large component of the [K+]o increase may involve a GABA-evoked Ca2+-activated gk, secondary to [Ca2+]i increase. A major part of [Cl-]o changes may arise from GABA-induced g(Cl) and glial efflux, with strong stimulation of active outward transport and anion exchange at SP, and inward Na+/K+/2Cl- co-transport at SR. Na+ influx is attributable mainly to Na+-dependent transmitter uptake, with only a small amount related to GABA(A) receptor activation. Although the release and (or) accumulation of GABA during anoxia might be viewed as potentially protectant, the ultimate role may more likely be an important contribution to toxicity and delayed neuronal death. JF - Canadian journal of physiology and pharmacology AU - Obrocea, G V AU - Morris, M E AD - Department of Health and Human Services, National Institutes of Health/National Institute of Mental Health, Bethesda, MD 20892-1272, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 378 EP - 391 VL - 78 IS - 5 SN - 0008-4212, 0008-4212 KW - Chlorides KW - 0 KW - GABA Antagonists KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Sodium KW - 9NEZ333N27 KW - Nitrogen KW - N762921K75 KW - Potassium KW - RWP5GA015D KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Bicuculline -- pharmacology KW - Animals KW - Guinea Pigs KW - Extracellular Space -- metabolism KW - In Vitro Techniques KW - Nitrogen -- pharmacology KW - Electrophysiology KW - GABA Antagonists -- pharmacology KW - Extracellular Space -- drug effects KW - Microelectrodes KW - Pyramidal Tracts -- metabolism KW - Pyramidal Tracts -- drug effects KW - gamma-Aminobutyric Acid -- pharmacology KW - Hypoxia -- metabolism KW - Hippocampus -- metabolism KW - Chlorides -- metabolism KW - Potassium -- metabolism KW - Sodium -- metabolism KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71164838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+physiology+and+pharmacology&rft.atitle=Comparison+of+changes+evoked+by+GABA+%28gamma-aminobutyric+acid%29+and+anoxia+in+%5BK%2B%5Do%2C+%5BCl-%5Do%2C+and+%5BNa%2B%5Do+in+stratum+pyramidale+and+stratum+radiatum+of+the+guinea+pig+hippocampus.&rft.au=Obrocea%2C+G+V%3BMorris%2C+M+E&rft.aulast=Obrocea&rft.aufirst=G&rft.date=2000-05-01&rft.volume=78&rft.issue=5&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+physiology+and+pharmacology&rft.issn=00084212&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-15 N1 - Date created - 2000-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Temporal development of 2',3'-dideoxyinosine (ddI)-induced peripheral myelinopathy. AN - 71163641; 10840187 AB - The anti-HIV therapeutic dideoxyinosine (ddI) has been reported to produce a painful, dose-limiting peripheral myelinopathy in HIV-infected patients after chronic administration. We have previously demonstrated ddI-induced myelinopathy in a non-HIV-infected rat model after 20 weeks of dosing, characterized by myelin splitting and intramyelin edema. The present study examined the time course needed to produce the ddI-induced neuropathy. Adult male Sprague-Dawley rats were gavaged with vehicle or 415 mg/kg ddI twice daily for up to 20 weeks. Groups of treated (n = 6-8) and control (n = 3-5) animals were killed after 5, 10, 15, and 20 weeks of dosing and the distal end of the sciatic nerve was removed. The nerve was postfixed by immersion in neutral phosphate-buffered formalin, dehydrated in graded alcohols, and embedded in plastic embedding media. One-micrometer-thick sections were cut and stained with toluidine blue and basic fuchsin. Plasma levels of ddI on the day the animals were killed were greater than 10 microgram/ml within the first hour after dosing and fell rapidly to less than 1 microgram/ml (clinical range 1-2 microgram/ml) within 3 h after dosing. The abnormalities observed in the sciatic nerve were few, if any, after 5 or 10 weeks, but very prominent after 15 weeks of dosing. Four of the six ddI-treated rats exhibited abnormal morphology as evidenced by myelin splitting and ballooned myelin sheaths. Although abnormal morphology was present at 20 weeks of dosing, the effect was not as robust as at 15 weeks. This suggests that the nerve may partially recover from the effects of ddI with time. Published by Elsevier Science Inc. JF - Neurotoxicology and teratology AU - Patterson, T A AU - Schmued, L C AU - Sandberg, J A AU - Slikker, W AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 72079-9502, Jefferson, AR, USA. tpatterson@nctr.fda.gov PY - 2000 SP - 429 EP - 434 VL - 22 IS - 3 SN - 0892-0362, 0892-0362 KW - Anti-HIV Agents KW - 0 KW - Didanosine KW - K3GDH6OH08 KW - Index Medicus KW - AIDS/HIV KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Blood Chemical Analysis KW - Sciatic Nerve -- pathology KW - Male KW - Didanosine -- toxicity KW - Anti-HIV Agents -- toxicity KW - Didanosine -- blood KW - Myelin Sheath -- pathology KW - Peripheral Nervous System Diseases -- pathology KW - Anti-HIV Agents -- blood KW - Peripheral Nervous System Diseases -- chemically induced KW - Neurotoxicity Syndromes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71163641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Temporal+development+of+2%27%2C3%27-dideoxyinosine+%28ddI%29-induced+peripheral+myelinopathy.&rft.au=Patterson%2C+T+A%3BSchmued%2C+L+C%3BSandberg%2C+J+A%3BSlikker%2C+W&rft.aulast=Patterson&rft.aufirst=T&rft.date=2000-05-01&rft.volume=22&rft.issue=3&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-12 N1 - Date created - 2000-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minimal behavioral effects from developmental cerebellar stunting in young rats induced by postnatal treatment with alpha-difluoromethylornithine. AN - 71163233; 10840185 AB - Postnatal treatment with alpha-difluoromethylornithine (DFMO), a potent inhibitor of ornithine decarboxylase, reduces polyamine levels in rats. Because polyamines are critically involved in growth and development, body and/or brain weights are often decreased by DFMO treatment. Here, rats were injected subcutaneously with 0, 250, 500, or 750 mg/kg of DFMO on postnatal days (PNDs) 5-10. Behavioral assessments included righting reflex, negative geotaxis, forelimb hanging, open field activity, and rotarod performance. Additionally, day of eye opening was recorded and on PND 28, whole and regional brain weights were measured. Cerebellar/whole-brain ratio was decreased in a dose-dependent manner whereas frontal cortex/whole-brain ratio was increased. Eye opening was delayed to a similar extent in all treated groups whereas body weight was unaffected. alpha-difluoromethylornithine treatment had no significant effects on the assessed behaviors. These results indicate that 6 days of DFMO treatment can substantially impact cerebellar development, but this appears to have few effects on these early assessed behaviors. However, potential behavioral alterations may not be apparent until adulthood. Published by Elsevier Science Inc. JF - Neurotoxicology and teratology AU - Cada, A M AU - Gray, E P AU - Ferguson, S A AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 72079, Jefferson, AR, USA. PY - 2000 SP - 415 EP - 420 VL - 22 IS - 3 SN - 0892-0362, 0892-0362 KW - Enzyme Inhibitors KW - 0 KW - Ornithine Decarboxylase Inhibitors KW - Eflornithine KW - ZQN1G5V6SR KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Motor Activity -- physiology KW - Psychomotor Performance -- physiology KW - Postural Balance -- drug effects KW - Rats KW - Animals, Newborn KW - Forelimb -- physiology KW - Reflex -- physiology KW - Rats, Sprague-Dawley KW - Psychomotor Performance -- drug effects KW - Reflex -- drug effects KW - Postural Balance -- physiology KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Brain -- growth & development KW - Male KW - Eflornithine -- toxicity KW - Cerebellar Diseases -- chemically induced KW - Behavior, Animal -- drug effects KW - Cerebellum -- growth & development KW - Cerebellum -- drug effects KW - Enzyme Inhibitors -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71163233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Minimal+behavioral+effects+from+developmental+cerebellar+stunting+in+young+rats+induced+by+postnatal+treatment+with+alpha-difluoromethylornithine.&rft.au=Cada%2C+A+M%3BGray%2C+E+P%3BFerguson%2C+S+A&rft.aulast=Cada&rft.aufirst=A&rft.date=2000-05-01&rft.volume=22&rft.issue=3&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-12 N1 - Date created - 2000-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Octylphenol inhibits testosterone biosynthesis by cultured precursor and immature Leydig cells from rat testes. AN - 71156325; 10838129 AB - 4-tert-octyphenol (OP) is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. OP has been reported to mimic the actions of estrogen in many cellular systems. The present studies evaluated the direct effects of OP on human chorionic gonadotropin (hCG)-stimulated testosterone biosynthesis by cultured precursor and immature Leydig cells from 23-day old (prepubertal) rats. Exposure to increasing OP concentrations (1 to 2000 nM) progressively decreased hCG-stimulated testosterone formation in both precursor and immature Leydig cells at higher OP concentrations (100 or 500 to 2000 nM). Testosterone levels were reduced approximately 30 to 70% below control at the highest concentration in both cell types. Similar reductions in testosterone associated with OP exposure were observed in cells stimulated with 1 mM 8-Br-cAMP, suggesting that the main actions of OP occur after the generation of cAMP. Increasing concentrations of 17beta-estradiol (1 to 1000 nM) had no effect on hCG-stimulated testosterone formation in both precursor and immature Leydig cells and the inclusion of 100 nM ICI 182,780, a pure estrogen antagonist, in precursor and immature Leydig cells exposed to OP and hCG, did not alter the inhibition by higher OP concentrations of testosterone formation in both cell types. These results suggest that OP is a hormonally active agent, but that some of its actions are distinct from those of 17beta-estradiol and are not mediated through the estrogen receptor alpha or beta pathway. To further localize the potential site(s) of action of OP, cultured precursor and immature Leydig cells were exposed to increasing concentrations of OP and hCG for 24 h. Next, fresh media containing 1 microM 22(R)-hydroxycholesterol, 1 microM pregnenolone, 1 microM progesterone, or 1 microM androstenedione was added, and the conversion of each substrate to testosterone was determined after incubation for 4 h. The conversion of androstenedione to testosterone was unaffected by exposure to OP, suggesting that the 17beta-hydroxysteroid dehydrogenase step is not inhibited. However, the conversion of 22(R)-hydroxycholesterol, pregnenolone and progesterone all were inhibited by prior exposure to OP and hCG. This finding suggests that the 17alpha-hydroxylase/c17-20-lyase step, which converts progesterone to androstenedione, is inhibited by OP, and that the cholesterol side-chain cleavage and 3beta-hydroxysteroid dehydrogenase -isomerase steps, which convert cholesterol to pregnenolone and pregnenolone to progesterone, respectively, are other potential sites of OP action. Because concomitant exposure to the antioxidants alpha-tocopherol or ascorbate did not alter the inhibition of testosterone formation by higher OP concentrations, it does not appear that OP is acting as a pseudosubstrate for the generation of free radicals, which can damage P450 enzymes. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Murono, E P AU - Derk, R C AU - de León, J H AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S 2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. EEM8@CDC.GOV PY - 2000 SP - 275 EP - 288 VL - 14 IS - 3 SN - 0890-6238, 0890-6238 KW - Chorionic Gonadotropin KW - 0 KW - Estrogen Antagonists KW - Estrogens, Non-Steroidal KW - Hydroxycholesterols KW - Phenols KW - 22-hydroxycholesterol KW - 17711-16-9 KW - 4,5-dimethoxy-2-nitrobenzyl-8-bromo-cAMP KW - 177592-87-9 KW - fulvestrant KW - 22X328QOC4 KW - Testosterone KW - 3XMK78S47O KW - Androstenedione KW - 409J2J96VR KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Pregnenolone KW - 73R90F7MQ8 KW - 4-octylphenol KW - 7DF2B8LH3P KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Pregnenolone -- pharmacology KW - Animals KW - Hydroxycholesterols -- metabolism KW - Dose-Response Relationship, Drug KW - Progesterone -- pharmacology KW - Estradiol -- pharmacology KW - Androstenedione -- pharmacology KW - Cyclic AMP -- analogs & derivatives KW - Rats KW - Estradiol -- analogs & derivatives KW - Rats, Sprague-Dawley KW - Estrogen Antagonists -- pharmacology KW - Pregnenolone -- metabolism KW - Chorionic Gonadotropin -- pharmacology KW - Progesterone -- metabolism KW - Cells, Cultured KW - Hydroxycholesterols -- pharmacology KW - Cyclic AMP -- pharmacology KW - Androstenedione -- metabolism KW - Male KW - Leydig Cells -- metabolism KW - Estrogens, Non-Steroidal -- antagonists & inhibitors KW - Estrogens, Non-Steroidal -- toxicity KW - Phenols -- toxicity KW - Testosterone -- biosynthesis KW - Testosterone -- antagonists & inhibitors KW - Leydig Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71156325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Octylphenol+inhibits+testosterone+biosynthesis+by+cultured+precursor+and+immature+Leydig+cells+from+rat+testes.&rft.au=Murono%2C+E+P%3BDerk%2C+R+C%3Bde+Le%C3%B3n%2C+J+H&rft.aulast=Murono&rft.aufirst=E&rft.date=2000-05-01&rft.volume=14&rft.issue=3&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-01 N1 - Date created - 2000-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liquid chromatographic analysis of incurred amoxicillin residues in catfish muscle following oral administration of the drug. AN - 71132388; 10820077 AB - Improper application of antibiotic chemicals to livestock and aquaculture species may lead to the occurrence of residues in food supplies. An appropriate depletion period is needed after the administration of drugs to animals for ensuring that residues in edible tissues are below established tolerance levels. This study was conducted to determine incurred amoxicillin residues in catfish muscle following oral administration. Dosed fish were harvested after four depletion periods, and muscle fillets were analyzed for amoxicillin residues using an HPLC method with precolumn derivatization and fluorescence detection. The residue levels in fish after a 6-h depletion ranged from 40 to 64 ng/g with one exception at 297 ng/g. Average residue levels decreased to 5.4 and 2. 8 ng/g after 24- and 48-h depletions, respectively. Residue levels after a 72-h depletion decreased to below the method's limit of quantitation (1.2 ng/g). An LC-MS/MS confirmatory method was developed. Confirmation of the presence of amoxicillin was demonstrated in incurred fish samples containing residues at approximately 50-300 ng/g. JF - Journal of agricultural and food chemistry AU - Ang, C Y AU - Liu, F F AU - Lay, J O AU - Luo, W AU - McKim, K AU - Gehring, T AU - Lochmann, R AD - Division of Chemistry, National Center for Toxicological Research, U. S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. cang@nctr.fda.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1673 EP - 1677 VL - 48 IS - 5 SN - 0021-8561, 0021-8561 KW - Penicillins KW - 0 KW - Amoxicillin KW - 804826J2HU KW - Index Medicus KW - Administration, Oral KW - Animals KW - Ictaluridae KW - Spectrometry, Fluorescence KW - Muscles -- chemistry KW - Amoxicillin -- administration & dosage KW - Amoxicillin -- analysis KW - Drug Residues -- analysis KW - Penicillins -- administration & dosage KW - Penicillins -- analysis KW - Chromatography, High Pressure Liquid -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71132388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Liquid+chromatographic+analysis+of+incurred+amoxicillin+residues+in+catfish+muscle+following+oral+administration+of+the+drug.&rft.au=Ang%2C+C+Y%3BLiu%2C+F+F%3BLay%2C+J+O%3BLuo%2C+W%3BMcKim%2C+K%3BGehring%2C+T%3BLochmann%2C+R&rft.aulast=Ang&rft.aufirst=C&rft.date=2000-05-01&rft.volume=48&rft.issue=5&rft.spage=1673&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-28 N1 - Date created - 2000-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incidence of Salmonella in fish and seafood. AN - 71132005; 10826714 AB - Field laboratories of the U.S. Food and Drug Administration collected and tested 11,312 import and 768 domestic seafood samples over a 9-year period (1990 to 1998) for the presence of Salmonella. The overall incidence of Salmonella was 7.2% for import and 1.3% for domestic seafood. Nearly 10% of import and 2.8% of domestic raw seafood were positive for Salmonella. The overall incidence of Salmonella in ready-to-eat seafood and shellfish eaten raw was 0.47% for domestic--one shucked oyster and one shark cartilage powder. The incidence in the 2,734 ready-to-eat import seafood was 2.6%--cooked shrimp, shellfish or fish paste, smoked fish, salted/dried fish, and caviar. The incidence in import shellfish consumed raw was 1% in oyster, 3.4% in clams, and 0% in mussels. The incidence in raw, import fish was 12.2%. Distribution of Salmonella in seafood on a regional basis indicated the incidence to be highest in central Pacific and Africa and lowest in Europe/Russia and North America (12% versus 1.6%). Data on a country basis indicated Vietnam to have the highest (30%) and Republic of Korea the lowest (0.7%). While the most frequent serotypes in import seafood were Salmonella Weltevreden (1st), Salmonella Senftenberg (2nd), Salmonella Lexington, and Salmonella Paratyphi-B (3rd, equal numbers for each serotype), the top 20 list included Salmonella enteritidis (5th), Salmonella Newport (6th), Salmonella Thompson (7th), Salmonella typhimurium (12th), and Salmonella anatum (13th), commonly involved in foodborne illness in the United States. Because the incidence in the present study is based on only a small fraction of the seafood imported into the United States, efforts should be directed toward implementation of hazard analysis and critical control points to reduce the incidence of Salmonella in seafood without relying on testing for Salmonella. JF - Journal of food protection AU - Heinitz, M L AU - Ruble, R D AU - Wagner, D E AU - Tatini, S R AD - U.S. Food and Drug Administration, Minneapolis, Minnesota 55401-1999, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 579 EP - 592 VL - 63 IS - 5 SN - 0362-028X, 0362-028X KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Incidence KW - Fishes -- microbiology KW - Food Microbiology KW - Seafood -- microbiology KW - Salmonella -- isolation & purification KW - Salmonella -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71132005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Incidence+of+Salmonella+in+fish+and+seafood.&rft.au=Heinitz%2C+M+L%3BRuble%2C+R+D%3BWagner%2C+D+E%3BTatini%2C+S+R&rft.aulast=Heinitz&rft.aufirst=M&rft.date=2000-05-01&rft.volume=63&rft.issue=5&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-01 N1 - Date created - 2000-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to low-frequency electromagnetic fields does not alter HSP70 expression or HSF-HSE binding in HL60 cells. AN - 71122231; 10790289 AB - Environmental exposure to extremely low-frequency electromagnetic fields (ELF EMFs) has been identified as a possible contributor to increased cancer incidence and other diseases. In vitro studies designed to probe for biological mechanisms that might explain such relationships have included several studies of gene expression. While gene expression studies have focused on MYC, effects of ELF EMFs on the expression of beta-actin, histone H2B, beta-tubulin, SRC, FOS and JUN have also been reported. In addition, some investigators have reported both an induction of HSP70 expression and an increase in HSF-HSE binding in HL60 (human promyelocytic leukemia) cells after exposure to a 60 Hz magnetic field. In this study, HL60 cells were exposed to a weak 60 Hz magnetic field (6.3 or 8.0 microT) or to a positive control heat shock (42 or 44 degrees C). While heat shock led to reproducible induction of HSP70 expression and HSF-HSE binding, no significant effect of exposure to ELF EMFs on either of these end points was observed. JF - Radiation research AU - Morehouse, C A AU - Owen, R D AD - FDA Center for Devices and Radiological Health, Rockville, Maryland 20850, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 658 EP - 662 VL - 153 IS - 5 Pt 2 SN - 0033-7587, 0033-7587 KW - DNA-Binding Proteins KW - 0 KW - HSP70 Heat-Shock Proteins KW - Transcription Factors KW - heat shock transcription factor KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Promoter Regions, Genetic -- physiology KW - Blotting, Northern KW - Reproducibility of Results KW - HL-60 Cells KW - Humans KW - DNA -- metabolism KW - Hot Temperature -- adverse effects KW - Electrophoresis, Agar Gel KW - Promoter Regions, Genetic -- genetics KW - Dose-Response Relationship, Radiation KW - Protein Binding -- radiation effects KW - HSP70 Heat-Shock Proteins -- genetics KW - HSP70 Heat-Shock Proteins -- biosynthesis KW - Heat-Shock Response -- radiation effects KW - Electromagnetic Fields -- adverse effects KW - Gene Expression -- physiology KW - Gene Expression -- radiation effects KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71122231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Exposure+to+low-frequency+electromagnetic+fields+does+not+alter+HSP70+expression+or+HSF-HSE+binding+in+HL60+cells.&rft.au=Morehouse%2C+C+A%3BOwen%2C+R+D&rft.aulast=Morehouse&rft.aufirst=C&rft.date=2000-05-01&rft.volume=153&rft.issue=5+Pt+2&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-09 N1 - Date created - 2000-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential toxicities of HIV therapeutics in the developing infant. AN - 71104732; 10777839 JF - Teratology AU - Slikker, W AU - Olivero, O A AU - Patterson, T A AU - Poirier, M C AD - Division of Neurotoxicology, NCTR, Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA. wslikker@nctr.fda.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 397 EP - 398 VL - 61 IS - 5 SN - 0040-3709, 0040-3709 KW - Anti-HIV Agents KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - DNA KW - 9007-49-2 KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Amniotic Fluid -- metabolism KW - Fetus -- drug effects KW - Fetal Blood -- metabolism KW - Macaca mulatta KW - Tissue Distribution KW - Female KW - Pregnancy KW - Anti-HIV Agents -- toxicity KW - Maternal-Fetal Exchange KW - Zidovudine -- pharmacokinetics KW - Anti-HIV Agents -- pharmacokinetics KW - Zidovudine -- toxicity KW - DNA -- metabolism KW - Placenta -- metabolism KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71104732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Potential+toxicities+of+HIV+therapeutics+in+the+developing+infant.&rft.au=Slikker%2C+W%3BOlivero%2C+O+A%3BPatterson%2C+T+A%3BPoirier%2C+M+C&rft.aulast=Slikker&rft.aufirst=W&rft.date=2000-05-01&rft.volume=61&rft.issue=5&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-01 N1 - Date created - 2000-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Workplace managed care: collaboration for substance abuse prevention. AN - 71092614; 10795123 AB - This article describes the history, purpose, and overall methodology of the Workplace Managed Care (WMC) study sponsored by the Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention (CSAP). This study was initiated to discern best practices for workplaces and managed care organizations integrating their substance abuse prevention and early intervention programs, strategies, and activities for employees and their families. CSAP funded nine WMC grants to study their retrospective and prospective data. Results of the WMC study suggested the addition of substance abuse prevention material to existing workplace health promotion offerings that resulted in improved substance abuse attitudes without jeopardizing existing health promotion programs. Stress management programming was successful at improving substance abuse attitudes indirectly. This study provides a platform for multidisciplinary research in workplace and managed care settings. JF - The journal of behavioral health services & research AU - Galvin, D M AD - Division of Workplace Programs, Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, Rockville, MD 20878, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 125 EP - 130 VL - 27 IS - 2 SN - 1094-3412, 1094-3412 KW - Index Medicus KW - United States KW - Models, Organizational KW - Humans KW - Health Promotion -- methods KW - Occupational Health Services -- organization & administration KW - Occupational Health Services -- legislation & jurisprudence KW - Managed Care Programs -- economics KW - Managed Care Programs -- organization & administration KW - Workplace -- organization & administration KW - Substance-Related Disorders -- economics KW - Workplace -- economics KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71092614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+behavioral+health+services+%26+research&rft.atitle=Workplace+managed+care%3A+collaboration+for+substance+abuse+prevention.&rft.au=Galvin%2C+D+M&rft.aulast=Galvin&rft.aufirst=D&rft.date=2000-05-01&rft.volume=27&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+journal+of+behavioral+health+services+%26+research&rft.issn=10943412&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-28 N1 - Date created - 2000-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An evaluation of l-ephedrine neurotoxicity with respect to hyperthermia and caudate/putamen microdialysate levels of ephedrine, dopamine, serotonin, and glutamate. AN - 71078109; 10788568 AB - l-Ephedrine is an active ingredient in several herbal formulations with a mechanism of action similar to amphetamine and methamphetamine. However, its potential to damage dopaminergic terminals in the caudate/putamen (CPu) has yet to be fully evaluated. The studies here used in vivo brain microdialysis experiments to determine the systemic doses and extracellular brain levels of l-ephedrine necessary to produce similar increases in CPu extracellular dopamine and marked hyperthermia that were previously shown necessary for amphetamine-induced neurotoxicity in male Sprague-Dawley rats. At an environmental temperature of 23 degrees C, a single 40 mg/kg intraperitoneal (ip) dose of l-ephedrine produced marked hyperthermia (>/= 40 degrees C), peak microdialysate ephedrine levels of 7.3 +/- 1.2 microM, and a 20-fold increase in microdialysate dopamine levels. Twenty-five mg/kg produced a lesser degree of hyperthermia, peak microdialysate ephedrine levels of 2.6 +/- 0.4 microM, and a 10-fold increase in dopamine levels. Three doses of 40 mg/kg given at 3-h intervals or 4 doses of 25 mg/kg l-ephedrine given at 2-h intervals were compared with 4 doses of 5 mg/kg d-amphetamine given at 2-h intervals. Multiple doses of either ephedrine or amphetamine caused severe hyperthermia (>/= 41.3 degrees C) but striatal tissue levels of dopamine 7 days after dosing were reduced only 25% or less by ephedrine compared to the 75% reductions produced by amphetamine. The increases in CPu microdialysate levels of serotonin produced by either 4 x 25 mg/kg l-ephedrine or 4 x 5 mg/kg d-amphetamine did not significantly differ, but elevation of dopamine levels by d-amphetamine were over 2-fold times the level caused by l-ephedrine. Microdialysate glutamate levels were elevated to the same extent by either 25 mg/kg l-ephedrine or 4 x 5 mg/kg d-amphetamine. l-Ephedrine may not be as neurotoxic to dopaminergic terminals as d-amphetamine, because non-lethal doses of l-ephedrine do not sufficiently increase the CPu dopamine levels within nerve terminals or the extracellular space to those necessary for a more pronounced long-term dopamine depletion. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Bowyer, J F AU - Newport, G D AU - Slikker, W AU - Gough, B AU - Ferguson, S A AU - Tor-Agbidye, J AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. jbowyer@nctr.fda.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 133 EP - 142 VL - 55 IS - 1 SN - 1096-6080, 1096-6080 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Uptake Inhibitors KW - Neurotoxins KW - Serotonin KW - 333DO1RDJY KW - Glutamic Acid KW - 3KX376GY7L KW - Ephedrine KW - GN83C131XS KW - Dextroamphetamine KW - TZ47U051FI KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Dopamine Uptake Inhibitors -- toxicity KW - Animals KW - Rats, Sprague-Dawley KW - Glutamic Acid -- metabolism KW - Isomerism KW - Dopamine -- metabolism KW - Dextroamphetamine -- toxicity KW - Serotonin -- metabolism KW - Male KW - Chromatography, High Pressure Liquid KW - Fever -- chemically induced KW - Caudate Nucleus -- metabolism KW - Central Nervous System Stimulants -- toxicity KW - Central Nervous System Stimulants -- metabolism KW - Nervous System Diseases -- metabolism KW - Putamen -- metabolism KW - Ephedrine -- metabolism KW - Caudate Nucleus -- drug effects KW - Fever -- physiopathology KW - Nervous System Diseases -- chemically induced KW - Neurotoxins -- toxicity KW - Ephedrine -- toxicity KW - Putamen -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71078109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=An+evaluation+of+l-ephedrine+neurotoxicity+with+respect+to+hyperthermia+and+caudate%2Fputamen+microdialysate+levels+of+ephedrine%2C+dopamine%2C+serotonin%2C+and+glutamate.&rft.au=Bowyer%2C+J+F%3BNewport%2C+G+D%3BSlikker%2C+W%3BGough%2C+B%3BFerguson%2C+S+A%3BTor-Agbidye%2C+J&rft.aulast=Bowyer&rft.aufirst=J&rft.date=2000-05-01&rft.volume=55&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-09 N1 - Date created - 2000-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thoughts on carcinogenesis testing: the FDA today. AN - 71051570; 10774776 AB - Prevention of human cancer in the future will depend on using the results of epidemiologic and animal studies and strategies to minimize exposure. Changes are occurring in the area of animal testing and research that potentially represent significant steps toward reducing our dependence on the traditional 2-year bioassay as our primary tool for identification of chemical carcinogens and management of risk. Efforts to prevent cancer would be enhanced by more attention to describing modes of action so that the development of tumors would not be the only basis for predicting carcinogenic potential. These markers might also serve for early detection of cancer at a stage more amenable to treatment. What carcinogens do we want to detect through animal tests in the future? Whether the goal is to identify weak or potent carcinogens, or both, there will still be a need for 2-year bioassays, but hopefully for confirmatory rather than screening purposes. JF - Drug metabolism reviews AU - Schwetz, B A AD - U.S. Food and Drug Administration, Rockville, Maryland 20857. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 211 EP - 214 VL - 32 IS - 2 SN - 0360-2532, 0360-2532 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Risk Management KW - United States Food and Drug Administration KW - Carcinogenicity Tests -- trends KW - Neoplasms -- epidemiology KW - Carcinogenicity Tests -- methods KW - Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71051570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Thoughts+on+carcinogenesis+testing%3A+the+FDA+today.&rft.au=Schwetz%2C+B+A&rft.aulast=Schwetz&rft.aufirst=B&rft.date=2000-05-01&rft.volume=32&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-11 N1 - Date created - 2000-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New issues in cancer risk assessment. AN - 71049280; 10774774 AB - When a nonlinear dose-response at low doses can be justified, an acceptable daily intake for a carcinogen can be obtained by dividing a benchmark dose, associated with a low incidence of tumors in animals, by uncertainty factors to account for animal-to-human extrapolation, human variability, and risk reduction from a low observed adverse-effect level. This approach can utilize mechanistic information to justify smaller uncertainty factors than typical default values of 10. If a nonlinear dose-response cannot be justified, traditional linear extrapolation from the benchmark dose to zero sometimes gives similar results. This suggests a unified risk-assessment procedure based on uncertainty factors. The issue of cross-species extrapolation based on the risk relative to background risks, rather than excess risk, is examined. The relative risk approach reduces the estimates of cancer risk in humans based on common rodent tumors, such as the liver in some strains of mice. JF - Drug metabolism reviews AU - Gaylor, D W AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 187 EP - 192 VL - 32 IS - 2 SN - 0360-2532, 0360-2532 KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Species Specificity KW - Neoplasms -- epidemiology KW - Carcinogenicity Tests KW - Risk Assessment -- methods KW - Risk Assessment -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71049280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=New+issues+in+cancer+risk+assessment.&rft.au=Gaylor%2C+D+W&rft.aulast=Gaylor&rft.aufirst=D&rft.date=2000-05-01&rft.volume=32&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-11 N1 - Date created - 2000-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic activation capacity of neonatal mice in relation to the neonatal mouse tumorigenicity bioassay. AN - 71046209; 10774778 AB - The neonatal mouse tumorigenicity bioassay is a well-developed animal model that has recently been recommended as an alternative tumorigenicity bioassay by the International Conference on Harmonization (ICH) for Technical Requirements for the Registration of Pharmaceuticals for Human Use. There are sufficient data to conclude that this animal model is highly sensitive to genotoxic chemical carcinogens that exert their tumorigenicity through mechanisms involving the formation of covalently bound exogenous DNA adducts that lead to mutation. On the other hand, it is not sensitive to chemical carcinogens that exert tumorigenicity through a secondary mechanism. The metabolizing enzymes present in the neonatal mouse, particularly the cytochromes P450, are critical factors in determining the tumorigenic potency of a chemical tested in this bioassay. However, compared to the metabolizing enzymes of the adult mouse and rat, the study of the metabolizing enzymes in neonatal mouse tissues has been relatively limited. JF - Drug metabolism reviews AU - Fu, P P AU - Von Tungeln, L S AU - Hammons, G J AU - McMahon, G AU - Wogan, G AU - Flammang, T J AU - Kadlubar, F F AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 241 EP - 266 VL - 32 IS - 2 SN - 0360-2532, 0360-2532 KW - Carcinogens KW - 0 KW - DNA Adducts KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - ras Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Humans KW - ras Proteins -- biosynthesis KW - Cytochrome P-450 Enzyme System -- metabolism KW - Mice KW - Carcinogens -- metabolism KW - Biotransformation KW - Carcinogens -- toxicity KW - Carcinogenicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71046209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Metabolic+activation+capacity+of+neonatal+mice+in+relation+to+the+neonatal+mouse+tumorigenicity+bioassay.&rft.au=Fu%2C+P+P%3BVon+Tungeln%2C+L+S%3BHammons%2C+G+J%3BMcMahon%2C+G%3BWogan%2C+G%3BFlammang%2C+T+J%3BKadlubar%2C+F+F&rft.aulast=Fu&rft.aufirst=P&rft.date=2000-05-01&rft.volume=32&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-11 N1 - Date created - 2000-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proportionate mortality among unionized roofers and waterproofers. AN - 70983225; 10723042 AB - The United Union of Roofers, Waterproofers, and Allied Workers (UURWAW) is one of the 15 building and construction trades departments in the AFL-CIO. The U.S. roofing industry, including both roofing and waterproofing applications, both unionized and nonunionized, comprises about 25,000 firms, employing approximately 300,000 people, about 200,000 of whom are involved in the application of roofs. The specific toxins to which roofers may be exposed at the job site include, among others, bitumens (asphalt and/or coal tar pitch) as well as asbestos and fiberglass from roof removal operations. Excess deaths from occupational injuries are also of concern. This study evaluated causes of mortality among 11,144 members of the UURWAW. Age-adjusted proportionate mortality ratios (PMRs) were computed with 95% confidence intervals (CI) using U.S. age-, gender-, and race-specific proportional mortality rates for the years of the study, 1950-1996. Statistically significant increased PMRs were found for all injuries (PMR = 142, CI = 134-150), especially falls (PMR = 464, CI = 419-513) and other injuries (PMR = 121, CI = 107-137), cancers of the lung (PMR = 139, CI = 131-148), bladder (PMR = 138, CI = 111-170), esophagus (PMR = 134, CI = 107-166), larynx (PMR = 145, CI = 106-193), and cancers of other and unspecified sites (PMR = 130, CI = 112-149), pneumoconioses and other nonmalignant respiratory diseases (PMR = 115, CI = 103-128), and homicides (PMR = 153, CI = 135-172). The occupational exposures which may have contributed to the excess risks of malignant and nonmalignant respiratory diseases include, among others, asphalt fumes, coal tar pitch volatiles and asbestos; however, cigarette smoking must also be considered a contributing factor. The present study underscores the need to control airborne exposures to hazardous substances and especially to examine fall prevention efforts within the roofing industry. Am. J. Ind. Med. 37:478-492, 2000. Published 2000 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Stern, F B AU - Ruder, A M AU - Chen, G AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA. FBS1@CDC.GOV Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 478 EP - 492 VL - 37 IS - 5 SN - 0271-3586, 0271-3586 KW - Hydrocarbons KW - 0 KW - fiberglass KW - Asbestos KW - 1332-21-4 KW - Coal Tar KW - 8007-45-2 KW - asphalt KW - 8052-42-4 KW - Index Medicus KW - Age Factors KW - Humans KW - Pneumoconiosis -- mortality KW - Homicide -- statistics & numerical data KW - Coal Tar -- adverse effects KW - Esophageal Neoplasms -- mortality KW - Construction Materials -- adverse effects KW - Laryngeal Neoplasms -- mortality KW - Adult KW - Asbestos -- adverse effects KW - Hydrocarbons -- adverse effects KW - Male KW - Sex Factors KW - Continental Population Groups KW - Glass KW - Accidental Falls -- mortality KW - Case-Control Studies KW - Urinary Bladder Neoplasms -- mortality KW - Confidence Intervals KW - Lung Neoplasms -- mortality KW - Middle Aged KW - Accidents, Occupational -- mortality KW - United States -- epidemiology KW - Wounds and Injuries -- mortality KW - Female KW - Proportional Hazards Models KW - Labor Unions -- statistics & numerical data KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70983225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Proportionate+mortality+among+unionized+roofers+and+waterproofers.&rft.au=Stern%2C+F+B%3BRuder%2C+A+M%3BChen%2C+G&rft.aulast=Stern&rft.aufirst=F&rft.date=2000-05-01&rft.volume=37&rft.issue=5&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-02 N1 - Date created - 2000-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Oral health in America: a report of the Surgeon General AN - 59834693; 2001-0901870 AB - Focuses on five key questions: what is oral health; status of oral health in America; relationship between oral health and general health and well-being; how oral health is promoted and maintained, and how are oral diseases prevented; and needs and opportunities to enhance oral health; 1980s-1990s, chiefly. JF - United States Department of Health and Human Services, May 2000. Y1 - 2000/05// PY - 2000 DA - May 2000 PB - United States Department of Health and Human Services KW - Dental service -- United States KW - Public health -- United States KW - Diseases -- Prevention KW - United States -- Health conditions KW - Dental service, Cost of -- United States KW - United States -- Surgeon general UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59834693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Oral+health+in+America%3A+a+report+of+the+Surgeon+General&rft.title=Oral+health+in+America%3A+a+report+of+the+Surgeon+General&rft.issn=&rft_id=info:doi/ L2 - http://www.surgeongeneral.gov/library/oralhealth LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Document feature - bibl(s), table(s), chart(s), map(s), index(es) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Toward a safe workplace: The role of systematic reviews AN - 18536775; 5493023 JF - American Journal of Preventive Medicine AU - Rosenstock, L AU - Thacker, S B AD - National Institute for Occupational Safety and Health, Washington, DC, USA Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 4 EP - 5 VL - 18 IS - 4 SN - 0749-3797, 0749-3797 KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18536775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Toward+a+safe+workplace%3A+The+role+of+systematic+reviews&rft.au=Rosenstock%2C+L%3BThacker%2C+S+B&rft.aulast=Rosenstock&rft.aufirst=L&rft.date=2000-05-01&rft.volume=18&rft.issue=4&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Detection of Norwalk-like Virus in Shellfish Implicated in Illness AN - 18082347; 5167034 AB - In the 1990s, Norwalk-like viruses (NLVs) were identified in patient specimens as the primary pathogen associated with shellfish-borne gastroenteritis in the United States. Identification of these viruses from implicated shellfish has been difficult due to inefficient recovery of viruses, natural polymerase chain reaction (PCR) inhibitors in shellfish, and low virus contamination. Recent improvements to the method of detecting NLVs in shellfish include enhanced processing of virus and shellfish samples, application of nested PCR and nucleotide sequencing, and increased knowledge of NLV genetic diversity. Using a newly developed and sensitive method, an NLV G2 strain was identified in 2 oyster samples implicated in a 1998 California outbreak involving 171 cases. NLV capsid primers demonstrated a greater specificity of PCR detection than did polymerase primers. The 175-base viral capsid nucleotide sequences derived from oysters were 100% identical to those derived from a patient stool sample. This finding supports the epidemiologic associations indicating that contaminated shellfish serve as the vehicle for NLV transmission. JF - Journal of Infectious Diseases AU - Shieh, Y-S AU - Monroe, S S AU - Fankhauser, R L AU - Langlois, G W AU - Burkhardt, W III AU - Baric, R S AD - US Food and Drug Administration Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, USA Y1 - 2000/05// PY - 2000 DA - May 2000 SP - S360 EP - S366 VL - 181 SN - 0022-1899, 0022-1899 KW - Viruses KW - food-borne diseases KW - gastroenteritis KW - polymerase chain reaction KW - shellfish KW - Health & Safety Science Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Marine KW - Human diseases KW - Nucleotide sequence KW - Brackish KW - Food poisoning KW - Genetic diversity KW - Microbial contamination KW - Food contamination KW - Crassostrea KW - Food-borne diseases KW - USA KW - INE, USA, California KW - Polymerase chain reaction KW - Primers KW - Shellfish KW - USA, California KW - Seafood KW - Norwalk-like virus KW - Gastroenteritis KW - V 22160:Viral infections of invertebrates KW - A 01017:Human foods KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18082347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Detection+of+Norwalk-like+Virus+in+Shellfish+Implicated+in+Illness&rft.au=Shieh%2C+Y-S%3BMonroe%2C+S+S%3BFankhauser%2C+R+L%3BLanglois%2C+G+W%3BBurkhardt%2C+W+III%3BBaric%2C+R+S&rft.aulast=Shieh&rft.aufirst=Y-S&rft.date=2000-05-01&rft.volume=181&rft.issue=&rft.spage=S360&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Human diseases; Nucleotide sequence; Polymerase chain reaction; Genetic diversity; Food poisoning; Shellfish; Seafood; Microbial contamination; Primers; Gastroenteritis; Food-borne diseases; Food contamination; Norwalk-like virus; Crassostrea; USA; INE, USA, California; USA, California; Brackish; Marine ER - TY - JOUR T1 - Exposure of Daudi Cells to Low-Frequency Magnetic Fields Does Not Elevate MYC Steady-State mRNA Levels AN - 17857650; 5973527 AB - The effect of extremely low-frequency electromagnetic field (ELF EMF) exposures to human health has been widely debated. Epidemiological studies have found a possible correlation between increased cancer incidence and environmental ELF EMF exposures. Results from in vitro studies performed to examine the possible underlying bioeffects of ELF EMFs have varied greatly. Reported effects range from robust and reproducible effects to undetectable. In this study, Daudi cells were exposed to 60 Hz magnetic fields for 20, 40 or 60 min at flux densities of 12.5, 50, 100 or 500 mu T. Exposures were performed in the Regional ELF-EMF Exposure Facility (Rockville, MD) to minimize variables that might contribute to a false positive effect. Exposures included sham/sham, exposed/sham or sham/exposed, and were performed with blinding with respect to type of exposure. 12-O-Tetradecanoylphorbol-13-acetate (TPA) treatment was used as a positive control. Total cellular RNA was isolated using a single-step technique. Human MYC expression was measured by northern blot hybridization as an indicator of the responsiveness of Daudi cells to experimental conditions. Beta-2-microglobulin (B2M) expression was measured simultaneously as an internal control. Exposure to a 60 Hz magnetic field did not significantly alter MYC expression in Daudi cells under any of the exposure conditions. JF - Radiation Research AU - Morehouse, CA AU - Owen, R D AD - FDA Center for Devices and Radiological Health, Rockville, Maryland 20850 Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 663 EP - 669 PB - Radiation Research Society VL - 153 IS - 5 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Myc protein KW - Magnetic fields KW - TPA KW - Electromagnetic fields KW - 12-O-Tetradecanoylphorbol-13-acetate KW - Cancer KW - mRNA KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17857650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Exposure+of+Daudi+Cells+to+Low-Frequency+Magnetic+Fields+Does+Not+Elevate+MYC+Steady-State+mRNA+Levels&rft.au=Morehouse%2C+CA%3BOwen%2C+R+D&rft.aulast=Morehouse&rft.aufirst=CA&rft.date=2000-05-01&rft.volume=153&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282000%291532.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=153&page=663 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Myc protein; Magnetic fields; Cancer; 12-O-Tetradecanoylphorbol-13-acetate; Electromagnetic fields; TPA; mRNA DO - http://dx.doi.org/10.1043/0033-7587(2000)153<0663:EODCTL>2.0.CO;2 ER - TY - JOUR T1 - An Explosive Situation AN - 17783738; 4830503 AB - Ethylene oxide sterilization facilities, which sterilize most of the medical equipment sold to doctor's offices and hospitals, face some inherent dangers from the ethylene oxide (EtO)-based cleaning process they use. An increased incidence of explosions at these facilities has brought safety concerns to the forefront in this industry. Between 1994 and 1998, 10 EtO-related explosions occurred at industrial sterilization facilities; the most serious of those explosions resulted in one death and 59 injuries. All the explosions resulted in damaged buildings and equipment. JF - Safety and Health AU - Palassis, J AU - Diether, J W AD - NIOSH Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 89 EP - 96 VL - 161 IS - 5 SN - 0891-1797, 0891-1797 KW - ethylene oxide KW - medical equipment KW - sterilization KW - Health & Safety Science Abstracts; Risk Abstracts KW - Fires KW - Explosions KW - Cleaning process KW - Hospitals KW - R2 23020:Technological risks KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17783738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+and+Health&rft.atitle=An+Explosive+Situation&rft.au=Palassis%2C+J%3BDiether%2C+J+W&rft.aulast=Palassis&rft.aufirst=J&rft.date=2000-05-01&rft.volume=161&rft.issue=5&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Safety+and+Health&rft.issn=08911797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hospitals; Cleaning process; Fires; Explosions ER - TY - JOUR T1 - Transfer of erythromycin resistance from poultry to human clinical strains of Staphylococcus aureus AN - 17552547; 4733974 AB - The transfer of ermA and ermC genes, the two most common resistance determinants of erythromycin resistance, was studied with Luria-Bertani broth in the absence of additional Ca super(2+) or Mg super(2+) ions. Fifteen human and five poultry isolates of Staphylococcus aureus, which were resistant to erythromycin but carried different genetic markers for erythromycin resistance, were used for conjugation. Since both the donors (Amp super(s)-Tet super(r)) and recipients (Amp super(r)-Tet super(s)) were resistant to erythromycin, the transconjugants were initially picked up as ampicillin- and tetracycline-resistant colonies. The resistance transfer mechanisms of the chromosomally located erythromycin rRNA methylase gene ermA and the plasmid-borne ermC gene were monitored by a multiplex PCR and gene-specific internal probing assay. Four groups of transconjugants, based upon the transfer of the ermA and/or ermC gene, were distinguished from each other by the use of this method. Selective antibiotic screening revealed only one type of transconjugant that was resistant to ampicillin and tetracycline. A high frequency of transfer (4.5 times 10 super(-3)) was observed in all of the 23 transconjugants obtained, and the direction of tetracycline and erythromycin resistance marker transfer was determined to be from poultry to clinical isolates. The transfers of the ermA and ermC genes were via transposition and transformation, respectively. JF - Journal of Clinical Microbiology AU - Khan, SA AU - Nawaz AU - Khan, A A AU - Cerniglia, CE AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, mnawaz@nctr.fda.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1832 EP - 1838 VL - 38 IS - 5 SN - 0095-1137, 0095-1137 KW - chickens KW - man KW - ermA gene KW - ermC gene KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Conjugation KW - Poultry KW - Ampicillin KW - Tetracyclines KW - Erythromycin KW - Gene transfer KW - Polymerase chain reaction KW - Staphylococcus aureus KW - Antibiotic resistance KW - A 01064:Microbial resistance KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17552547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Transfer+of+erythromycin+resistance+from+poultry+to+human+clinical+strains+of+Staphylococcus+aureus&rft.au=Khan%2C+SA%3BNawaz%3BKhan%2C+A+A%3BCerniglia%2C+CE&rft.aulast=Khan&rft.aufirst=SA&rft.date=2000-05-01&rft.volume=38&rft.issue=5&rft.spage=1832&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Poultry; Antibiotic resistance; Erythromycin; Gene transfer; Conjugation; Polymerase chain reaction; Ampicillin; Tetracyclines ER - TY - JOUR T1 - Rapid identification of Yersinia enterocolitica in blood by the 5' nuclease PCR assay AN - 17550795; 4733992 AB - Yersinia enterocolitica accounts for 50% of the clinical sepsis episodes caused by the transfusion of contaminated red blood cells. A 5' nuclease TaqMan PCR assay was developed to detect Y. enterocolitica in blood. Primers and a probe based on the nucleotide sequence of the 16S rRNA gene from Y. enterocolitica were designed. Whole-blood samples were spiked with various numbers of Y. enterocolitica cells, and total chromosomal DNA was extracted. When the TaqMan PCR assay was performed, as few as six bacteria spiked in 200 mu l of blood could be detected. The assay was specific and did not detect other Yersinia species. The TaqMan assay is easy to perform, takes 2 h, and has the potential for use in the rapid detection of Y. enterocolitica contamination in stored blood units. JF - Journal of Clinical Microbiology AU - Sen, K AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-320, 1401 Rockville Pike, Rockville, MD 20852, USA, Senk@cber.fda.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1953 EP - 1958 VL - 38 IS - 5 SN - 0095-1137, 0095-1137 KW - bioassays KW - man KW - identification KW - 5' Nuclease KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Blood KW - Chromosomes KW - Polymerase chain reaction KW - Yersinia enterocolitica KW - A 01116:Bacteria KW - J 02704:Enumeration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17550795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Rapid+identification+of+Yersinia+enterocolitica+in+blood+by+the+5%27+nuclease+PCR+assay&rft.au=Sen%2C+K&rft.aulast=Sen&rft.aufirst=K&rft.date=2000-05-01&rft.volume=38&rft.issue=5&rft.spage=1953&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Yersinia enterocolitica; Chromosomes; Polymerase chain reaction; Blood ER - TY - JOUR T1 - Physiological and genetic comparison of two aromatic hydrocarbon-degrading Sphingomonas strains. AN - 71166303; 10850662 AB - Sphingomonas yanoikuyae strain B1 is able to degrade a wider range of aromatic hydrocarbons than S. paucimobilis strain TNE12 can degrade. Various culture techniques were used to corroborate that B1 used m-xylene, biphenyl, toluene, naphthalene, and phenanthrene as sole carbon and energy sources. In contrast, TNE12 could not mineralize m-xylene, biphenyl, toluene, or naphthalene. However, fluoranthene served as carbon and energy source for TNE12 but not B1. Southern blots were performed using the cloned genomic region (approximately 23 kb) containing the degradative genes for the upstream pathways for biphenyl and m-xylene and a TOL plasmid-type meta operon from B1 as a probe against the KpnI restriction-digested total DNA of TNE12. This 23 kb probe hybridized to three KpnI-digested fragments of TNE12 DNA; thus significant homology existed between the aromatic hydrocarbon-degrading genes of B1 and TNE12. Further work with smaller probes revealed, however, that TNE12 DNA fragments did not hybridize with the probe containing the genes encoding for xylene monooxygenase and part of an aromatic dioxygenase. A recombinant plasmid, which contains only the genes for xylene monooxygenase, is able to complement TNE12 on m-xylene. These genes are, therefore, probably missing from TNE12. Hence, TNE12 cannot use monocyclic aromatics whereas B1 can. Pulsed field gel electrophoresis coupled with Southern blotting revealed that the aromatic degradative genes were on an approximately 240 kb plasmid of TNE12; the same genes in B1 are known to be chromosomal. JF - Molecules and cells AU - Shuttleworth, K L AU - Sung, J AU - Kim, E AU - Cerniglia, C E AD - Division of Microbiology, National Center for Toxicological Research US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2000/04/30/ PY - 2000 DA - 2000 Apr 30 SP - 199 EP - 205 VL - 10 IS - 2 SN - 1016-8478, 1016-8478 KW - DNA, Bacterial KW - 0 KW - Hydrocarbons, Aromatic KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - GGTACC-specific type II deoxyribonucleases KW - Index Medicus KW - Plasmids -- genetics KW - Blotting, Southern KW - DNA, Bacterial -- isolation & purification KW - DNA, Bacterial -- genetics KW - Genetic Complementation Test KW - Electrophoresis, Gel, Pulsed-Field KW - Biodegradation, Environmental KW - DNA, Bacterial -- analysis KW - Deoxyribonucleases, Type II Site-Specific -- metabolism KW - Genes, Bacterial KW - Sphingomonas -- growth & development KW - Sphingomonas -- metabolism KW - Sphingomonas -- genetics KW - Hydrocarbons, Aromatic -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71166303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecules+and+cells&rft.atitle=Physiological+and+genetic+comparison+of+two+aromatic+hydrocarbon-degrading+Sphingomonas+strains.&rft.au=Shuttleworth%2C+K+L%3BSung%2C+J%3BKim%2C+E%3BCerniglia%2C+C+E&rft.aulast=Shuttleworth&rft.aufirst=K&rft.date=2000-04-30&rft.volume=10&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Molecules+and+cells&rft.issn=10168478&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-25 N1 - Date created - 2000-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interactive effects of methyl-deficiency and dietary restriction on liver cell proliferation and telomerase activity in Fischer 344 rats pretreated with aflatoxin B(1). AN - 71023995; 10754206 AB - The effects of methyl-deficiency and dietary restriction (DR) on hepatic cell proliferation and telomerase activity was studied in male Fischer 344 rats pretreated with aflatoxin B(1) (AFB(1)). Five-week-old rats were gavaged 5 days per week for 3 weeks with AFB(1) (25 microg/rat per day) or solvent (100 microl 75% dimethylsulfoxide). Rats were then divided into four groups. Two groups were fed a methyl-sufficient (MS) diet either ab libitum (AL) or with DR. The other two groups were fed a methyl-deficient (MD) diet either AL or with DR. At 15, 20, and 32 weeks of age, hepatic cell proliferation, telomerase activity, and the number of glutathione S-transferase-P positive (GST-P(+)) foci were determined. DR reduced hepatic cell proliferation, while the MD diet and AFB(1) pretreatment increased cell proliferation. Telomerase activity was decreased by DR and increased by the MD diet and AFB(1) pretreatment. The same trend was observed with GST-P(+) foci: in AFB(1)-pretreated rats, methyl deficiency increased the number of foci, while DR decreased the number. These results are consistent with a role of telomerase in hepatocarcinogenesis. JF - Cancer letters AU - Chou, M W AU - Mikhailova, M V AU - Nichols, J AU - Poirier, L A AU - Warbritton, A AU - Beland, F A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson AR 72079, USA. mchou@nctr.fda.gov Y1 - 2000/04/28/ PY - 2000 DA - 2000 Apr 28 SP - 53 EP - 61 VL - 152 IS - 1 SN - 0304-3835, 0304-3835 KW - Carcinogens KW - 0 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Rats KW - Nutritional Status KW - Carcinogens -- pharmacology KW - Animals KW - Rats, Inbred F344 KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- enzymology KW - Male KW - Cell Division KW - Aflatoxin B1 -- pharmacology KW - Liver -- pathology KW - Liver -- enzymology KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- etiology KW - Choline Deficiency -- complications KW - Liver Neoplasms, Experimental -- enzymology KW - Food Deprivation KW - Telomerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71023995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Interactive+effects+of+methyl-deficiency+and+dietary+restriction+on+liver+cell+proliferation+and+telomerase+activity+in+Fischer+344+rats+pretreated+with+aflatoxin+B%281%29.&rft.au=Chou%2C+M+W%3BMikhailova%2C+M+V%3BNichols%2C+J%3BPoirier%2C+L+A%3BWarbritton%2C+A%3BBeland%2C+F+A&rft.aulast=Chou&rft.aufirst=M&rft.date=2000-04-28&rft.volume=152&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-31 N1 - Date created - 2000-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. AN - 71033196; 10753830 AB - Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of action. Between licensure and April 1999, the FDA received 15 reports of hemoglobinemia and/or hemoglobinuria following anti-D IGIV administration that met the case definition for this review. The mechanism responsible for hemoglobinemia and/or hemoglobinuria is unexplained. Review of these reports was prompted by the seriousness and the unexpectedness of treatment-associated sequelae experienced by 11 patients. Of these patients, 7 developed sufficient onset or exacerbation of anemia that orders were written for packed red blood cell transfusions, although only 6 patients were transfused. Eight patients experienced the onset or exacerbation of renal insufficiency, and 2 patients underwent dialysis. One patient died due to complications of exacerbated anemia. Six patients experienced 2 to 3 sequelae. Absent validated incidence data, a 1.5% estimated incidence rate from published clinical trial data and a 0.1% estimated reporting rate from FDA and drug utilization data were calculated for reported cases of hemoglobinemia and/or hemoglobinuria. This review presents the first case series of anti-D-IGIV-associated hemoglobinemia and/or hemoglobinuria and provides pretreatment and posttreatment clinical and laboratory findings of the case series patients. The primary purpose of this review is to increase awareness of this potentially serious occurrence among physicians and health care professionals who manage ITP patients treated with anti-D IGIV, thereby enabling prompt recognition and treatment of sequelae. (Blood. 2000;95:2523-2529) JF - Blood AU - Gaines, A R AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville Pike, Rockville, MD 20852, USA. gaines@cber.fda.gov Y1 - 2000/04/15/ PY - 2000 DA - 2000 Apr 15 SP - 2523 EP - 2529 VL - 95 IS - 8 SN - 0006-4971, 0006-4971 KW - Hemoglobins KW - 0 KW - Immunoglobulins, Intravenous KW - Isoantibodies KW - RHO(D) antibody KW - Rho(D) Immune Globulin KW - Abridged Index Medicus KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Isoantibodies -- administration & dosage KW - Purpura, Thrombocytopenic -- immunology KW - Purpura, Thrombocytopenic -- drug therapy KW - Hemoglobinuria -- chemically induced KW - Isoantibodies -- adverse effects KW - Hemoglobins -- deficiency KW - Purpura, Thrombocytopenic -- blood KW - Immunoglobulins, Intravenous -- adverse effects KW - Hemoglobinuria -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71033196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Acute+onset+hemoglobinemia+and%2For+hemoglobinuria+and+sequelae+following+Rh%28o%29%28D%29+immune+globulin+intravenous+administration+in+immune+thrombocytopenic+purpura+patients.&rft.au=Gaines%2C+A+R&rft.aulast=Gaines&rft.aufirst=A&rft.date=2000-04-15&rft.volume=95&rft.issue=8&rft.spage=2523&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-05 N1 - Date created - 2000-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The immunogenicity of single and combination DNA vaccines against tuberculosis AN - 17592082; 4705048 AB - DNA immunization is a promising new approach for the development of novel tuberculosis vaccines. In this study, the immune responses following the administration of single and combination tuberculosis DNA vaccines were evaluated. Single DNA vaccines encoding the MPT-63 and MPT-83 tuberculosis antigens evoked partial protection against an aerogenic challenge with M. tuberculosis Erdman in the mouse model of pulmonary tuberculosis. Immunization with a multivalent combination DNA vaccine (containing the ESAT-6, MPT-64, MPT-63, and KatG constructs) generated immune responses that indicated an absence of antigenic competition since antigen-specific cell-mediated and humoral responses were detected to each component of the mixture. More importantly, the combination vaccine elicited a strong protective response relative to the protection evoked by live BCG vaccine. JF - Vaccine AU - Morris, S AU - Kelley, C AU - Howard, A AU - Li, Zhongming AU - Collins, F AD - Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Building 29, Room 502, 29 Lincoln Drive, Bethesda, MD 20892, USA, morris@cber.fda.gov Y1 - 2000/04/14/ PY - 2000 DA - 2000 Apr 14 SP - 2155 EP - 2163 VL - 18 IS - 20 SN - 0264-410X, 0264-410X KW - mice KW - immunology KW - DNA vaccines KW - Mycobacterium tuberculosis KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Tuberculosis KW - Vaccines KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17592082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=The+immunogenicity+of+single+and+combination+DNA+vaccines+against+tuberculosis&rft.au=Morris%2C+S%3BKelley%2C+C%3BHoward%2C+A%3BLi%2C+Zhongming%3BCollins%2C+F&rft.aulast=Morris&rft.aufirst=S&rft.date=2000-04-14&rft.volume=18&rft.issue=20&rft.spage=2155&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Vaccines; Tuberculosis ER - TY - JOUR T1 - A multisite study of the effectiveness of methamphetamine treatment: an initiative of the Center for Substance Abuse Treatment. AN - 71260576; 10908001 AB - In 1998, responding to national and regional epidemiological data indicating that methamphetamine (MA) abuse was a growing problem in the United States, the Center for Substance Abuse Treatment (CSAT) initiated a multisite MA treatment study. Through a collaborative approach among CSAT, seven treatment sites, and a coordinating center, the study compares the clinical and cost effectiveness of a manualized, cognitive-behavioral outpatient treatment developed by the Matrix Center in Los Angeles to the treatment approaches currently employed by the treatment sites. The study also explores technology transfer issues associated with integrating the Matrix approach within existing treatment settings. CSAT's approach to the initiation and management of this type of study is discussed. JF - Journal of psychoactive drugs AU - Herrell, J M AU - Taylor, J A AU - Gallagher, C AU - Dawud-Noursi, S AD - Division of Practice and Systems Development, Center for Substance Abuse Treatment, Rockville, Maryland 20857, USA. Jherrell@samhsa.gov PY - 2000 SP - 143 EP - 147 VL - 32 IS - 2 SN - 0279-1072, 0279-1072 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Humans KW - United States -- epidemiology KW - Multicenter Studies as Topic -- economics KW - Substance-Related Disorders -- therapy KW - Central Nervous System Stimulants -- economics KW - Methamphetamine -- economics KW - Multicenter Studies as Topic -- methods KW - United States Substance Abuse and Mental Health Services Administration -- economics KW - Substance-Related Disorders -- economics KW - Substance Abuse Treatment Centers -- economics KW - United States Substance Abuse and Mental Health Services Administration -- legislation & jurisprudence KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71260576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=A+multisite+study+of+the+effectiveness+of+methamphetamine+treatment%3A+an+initiative+of+the+Center+for+Substance+Abuse+Treatment.&rft.au=Herrell%2C+J+M%3BTaylor%2C+J+A%3BGallagher%2C+C%3BDawud-Noursi%2C+S&rft.aulast=Herrell&rft.aufirst=J&rft.date=2000-04-01&rft.volume=32&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human health effects after exposure to 2,3,7,8-TCDD. AN - 71260358; 10912244 AB - In 1949, the first descriptions of human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD)-contaminated chemicals were reported after a trichlorophenol reactor explosion in Nitro, West Virginia, USA. Reported non-cancer health effects included a range of conditions affecting most systems. Additional reports of the health consequences of exposure continued through the remainder of the century. The majority of effects have been reported among highly exposed groups including occupational populations, such as chemical production workers, pesticide applicators, and individuals who handled or were exposed to materials treated with 2,3,7,8-TCDD-contaminated pesticides, and among residents of communities contaminated with tainted waste oil (Missouri, USA) and industrial effluent (Seveso, Italy). For only six exposed populations were biological measurements of 2,3,7,8-TCDD-contaminated collected and used to examine the relationship between non-cancer health effects and exposure. Of the many non-cancer health effects thought to be associated with 2,3,7,8-TCDD exposure, only chloracne, elevations in GGT and triglyceride levels, and alterations in FSH and LH were related to serum 2,3,7,8-TCDD levels. Mortality from cardiovascular diseases also appeared to be elevated among cohorts of exposed chemical workers and Seveso residents. Continued surveillance of the health of exposed populations will be useful in identifying the long-term effects of both high and low 2,3,7,8-TCDD exposure. JF - Food additives and contaminants AU - Sweeney, M H AU - Mocarelli, P AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinatti, OH 45226-1988, USA. mhs2@cdc.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 303 EP - 316 VL - 17 IS - 4 SN - 0265-203X, 0265-203X KW - Environmental Pollutants KW - 0 KW - Polychlorinated Dibenzodioxins KW - Index Medicus KW - Immune System -- drug effects KW - Accidents KW - Humans KW - Chemical and Drug Induced Liver Injury KW - Occupational Exposure -- adverse effects KW - Skin Diseases -- chemically induced KW - Nervous System Diseases -- chemically induced KW - Lipid Metabolism KW - Liver Diseases -- metabolism KW - Polychlorinated Dibenzodioxins -- adverse effects KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71260358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Human+health+effects+after+exposure+to+2%2C3%2C7%2C8-TCDD.&rft.au=Sweeney%2C+M+H%3BMocarelli%2C+P&rft.aulast=Sweeney&rft.aufirst=M&rft.date=2000-04-01&rft.volume=17&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-22 N1 - Date created - 2000-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety evaluation of immunomodulatory biopharmaceuticals: can we improve the predictive value of preclinical studies? AN - 71243152; 10918508 JF - Human & experimental toxicology AU - Black, L E AU - Green, J D AU - Rener, J AU - Dayan, A AU - Cavagnaro, J A AU - Spindler, P AU - Bussiere, J L AU - Bouchard, P AU - Inoue, T AU - Thomas, P T AU - Essayan, D M AU - Gillett, N A AU - Hart, T K AU - Hastings, K AU - House, R V AU - Latta, D AU - Liminga, U AU - Treacy, G AU - Wierda, D AD - Center for Biologics Evaluation and Research. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 205 EP - 207 VL - 19 IS - 4 SN - 0960-3271, 0960-3271 KW - Adjuvants, Immunologic KW - 0 KW - Index Medicus KW - Drug Evaluation, Preclinical KW - Adjuvants, Immunologic -- toxicity KW - Biopharmaceutics KW - Adjuvants, Immunologic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71243152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Safety+evaluation+of+immunomodulatory+biopharmaceuticals%3A+can+we+improve+the+predictive+value+of+preclinical+studies%3F&rft.au=Black%2C+L+E%3BGreen%2C+J+D%3BRener%2C+J%3BDayan%2C+A%3BCavagnaro%2C+J+A%3BSpindler%2C+P%3BBussiere%2C+J+L%3BBouchard%2C+P%3BInoue%2C+T%3BThomas%2C+P+T%3BEssayan%2C+D+M%3BGillett%2C+N+A%3BHart%2C+T+K%3BHastings%2C+K%3BHouse%2C+R+V%3BLatta%2C+D%3BLiminga%2C+U%3BTreacy%2C+G%3BWierda%2C+D&rft.aulast=Black&rft.aufirst=L&rft.date=2000-04-01&rft.volume=19&rft.issue=4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-01 N1 - Date created - 2000-09-01 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Acute effects of cocaine on play behaviour of rats. AN - 71227383; 10877123 AB - Play behaviours are exhibited by many mammalian species. The similarity of such behaviour across children, non-human primates and rats makes it an especially appropriate target for the investigation of drug- or toxicant-induced disruption. In this study the acute effects of cocaine on play behaviour in male and female Sprague-Dawley rats was assessed. Same-sex dyads of rats (postnatal day 35-36) were separated 24 h prior to testing. On the following day, one or both rats of the dyad were injected with the same dose of cocaine (0, 2.5, 5.0 or 20.00 mg/kg). Thirty minutes later the rats were placed together and, after 5 min of habituation, the frequency of pins and crawl-overs were measured for each subject. In dyads in which both rats were treated, crawl-overs and pinning behaviour were decreased by 20 mg/kg cocaine. In dyads in which only one rat was treated, there was marginal effect of cocaine treatment on pinning frequency, while crawl-overs were unaffected. Pinning frequency was not sexually dimorphic in either type of dyad; however, crawl-overs were more frequently exhibited by females in dyads in which only one rat was treated. Thus, pinning behaviour in juvenile rats appears somewhat more sensitive to cocaine-induced disruption than crawl-over behaviours. Additionally, the presence of an untreated rat appears to attenuate the play-disrupting effects of cocaine on pinning frequency. JF - Behavioural pharmacology AU - Ferguson, S A AU - Frisby, N B AU - Ali, S F AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA. SFerguson@nctr.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 175 EP - 179 VL - 11 IS - 2 SN - 0955-8810, 0955-8810 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Social Behavior KW - Male KW - Female KW - Behavior, Animal -- drug effects KW - Play and Playthings -- psychology KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71227383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Acute+effects+of+cocaine+on+play+behaviour+of+rats.&rft.au=Ferguson%2C+S+A%3BFrisby%2C+N+B%3BAli%2C+S+F&rft.aulast=Ferguson&rft.aufirst=S&rft.date=2000-04-01&rft.volume=11&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Percentiles of the product of uncertainty factors for establishing probabilistic reference doses. AN - 71200423; 10859783 AB - Exposure guidelines for potentially toxic substances are often based on a reference dose (RfD) that is determined by dividing a no-observed-adverse-effect-level (NOAEL), lowest-observed-adverse-effect-level (LOAEL), or benchmark dose (BD) corresponding to a low level of risk, by a product of uncertainty factors. The uncertainty factors for animal to human extrapolation, variable sensitivities among humans, extrapolation from measured subchronic effects to unknown results for chronic exposures, and extrapolation from a LOAEL to a NOAEL can be thought of as random variables that vary from chemical to chemical. Selected databases are examined that provide distributions across chemicals of inter- and intraspecies effects, ratios of LOAELs to NOAELs, and differences in acute and chronic effects, to illustrate the determination of percentiles for uncertainty factors. The distributions of uncertainty factors tend to be approximately lognormally distributed. The logarithm of the product of independent uncertainty factors is approximately distributed as the sum of normally distributed variables, making it possible to estimate percentiles for the product. Hence, the size of the products of uncertainty factors can be selected to provide adequate safety for a large percentage (e.g., approximately 95%) of RfDs. For the databases used to describe the distributions of uncertainty factors, using values of 10 appear to be reasonable and conservative. For the databases examined the following simple "Rule of 3s" is suggested that exceeds the estimated 95th percentile of the product of uncertainty factors: If only a single uncertainty factor is required use 33, for any two uncertainty factors use 3 x 33 approximately 100, for any three uncertainty factors use a combined factor of 3 x 100 = 300, and if all four uncertainty factors are needed use a total factor of 3 x 300 = 900. If near the 99th percentile is desired use another factor of 3. An additional factor may be needed for inadequate data or a modifying factor for other uncertainties (e.g., different routes of exposure) not covered above. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Gaylor, D W AU - Kodell, R L AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. vtaylor@nctr.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 245 EP - 250 VL - 20 IS - 2 SN - 0272-4332, 0272-4332 KW - Index Medicus KW - Probability KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Databases as Topic KW - Safety KW - Linear Models KW - Normal Distribution KW - Algorithms KW - Benchmarking KW - Species Specificity KW - Toxicology KW - Environmental Exposure -- statistics & numerical data KW - Models, Statistical KW - Risk Assessment -- statistics & numerical data KW - Environmental Exposure -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71200423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Percentiles+of+the+product+of+uncertainty+factors+for+establishing+probabilistic+reference+doses.&rft.au=Gaylor%2C+D+W%3BKodell%2C+R+L&rft.aulast=Gaylor&rft.aufirst=D&rft.date=2000-04-01&rft.volume=20&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-06 N1 - Date created - 2000-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemoglobin potentiates the production of reactive oxygen species by alveolar macrophages. AN - 71139805; 10813091 AB - The objectives of this investigation were (1) to determine the effects of hemoglobin on the production of reactive oxygen species by activated rat alveolar macrophages, (2) to determine a possible mechanism for these effects, and (3) to determine which part of the hemoglobin molecule is responsible for these effects. Production of reactive oxygen species by phorbol myristate acetate (PMA)-stimulated cells was assessed by measuring luminol-enhanced chemiluminescence (CL). Hemoglobin enhances PMA-stimulated CL in a dose-dependent manner. The effect is maximal at 0.5-1.0 microM hemoglobin where PMA-induced CL is increased by approximately 20-fold. Superoxide anion release from PMA-stimulated cells is not affected by hemoglobin. However, the hemoglobin-induced enhancement of PMA-stimulated CL is inhibited by superoxide dismutase, catalase, dimethylthiourea, or deferoxamine. These results suggest that hydroxyl radical may be formed from hydrogen peroxide which is derived from superoxide anion. Measurements of electron spin resonance spectra following spin trapping of radicals verify that hydroxyl radicals are produced by the cells in the presence of PMA and hemoglobin. The hemoglobin effects appear to require iron in a protoporphyrin complex, because hemin stimulates PMA-induced CL, whereas neither ferrous nor ferric iron has any effect. These findings taken together suggest that hemoglobin can act as a biological Fenton reagent to enhance the production of reactive oxygen species from alveolar macrophages and potentially contribute to lung damage during leakage of blood into the alveolar spaces. JF - Experimental lung research AU - Huffman, L J AU - Miles, P R AU - Shi, X AU - Bowman, L AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. ljh3@cdc.gov PY - 2000 SP - 203 EP - 217 VL - 26 IS - 3 SN - 0190-2148, 0190-2148 KW - Free Radical Scavengers KW - 0 KW - Hemoglobins KW - Protoporphyrins KW - Reactive Oxygen Species KW - Superoxides KW - 11062-77-4 KW - Hemin KW - 743LRP9S7N KW - Iron KW - E1UOL152H7 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Iron -- pharmacology KW - Protoporphyrins -- pharmacology KW - Cell Culture Techniques KW - Macrophage Activation -- drug effects KW - Rats KW - Hemin -- pharmacology KW - Superoxides -- metabolism KW - Rats, Sprague-Dawley KW - Luminescent Measurements KW - Electron Spin Resonance Spectroscopy KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Free Radical Scavengers -- pharmacology KW - Male KW - Macrophages, Alveolar -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Hemoglobins -- pharmacology KW - Macrophages, Alveolar -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71139805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Educational+Psychology&rft.atitle=Peer+victimization+and+authoritative+school+climate%3A+A+multilevel+approach&rft.au=Cornell%2C+Dewey%3BShukla%2C+Kathan%3BKonold%2C+Timothy&rft.aulast=Cornell&rft.aufirst=Dewey&rft.date=2015-11-01&rft.volume=107&rft.issue=4&rft.spage=1186&rft.isbn=&rft.btitle=&rft.title=Journal+of+Educational+Psychology&rft.issn=00220663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-09 N1 - Date created - 2000-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure and absorption of hazardous materials through the skin. AN - 71139221; 10828145 JF - International journal of occupational and environmental health AU - Boeniger, M F AU - Lushniak, B D AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-12, Cincinnati, Ohio 45116, USA. bdt1@cdc.gov PY - 2000 SP - 148 EP - 150 VL - 6 IS - 2 SN - 1077-3525, 1077-3525 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Threshold Limit Values KW - Maximum Allowable Concentration KW - In Vitro Techniques KW - Europe KW - Occupational Exposure -- prevention & control KW - Hazardous Substances -- adverse effects KW - Occupational Exposure -- standards KW - Skin Absorption KW - Hazardous Substances -- metabolism KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71139221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Exposure+and+absorption+of+hazardous+materials+through+the+skin.&rft.au=Boeniger%2C+M+F%3BLushniak%2C+B+D&rft.aulast=Boeniger&rft.aufirst=M&rft.date=2000-04-01&rft.volume=6&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-24 N1 - Date created - 2000-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dermal absorption and tissue disposition of 3,3',4, 4'-tetrachlorobiphenyl (TCB) in an ex-vivo pig model: assessing the impact of dermal exposure variables. AN - 71139184; 10828142 AB - TCB is one of the dioxin-like polychlorinated biphenyls (PCBs). This research was designed to help assess the risk of occupational and environmental TCB exposure. To evaluate exposure variables' effects on dermal absorption and cutaneous disposition, 14C-TCB (40 microg/cm(2)) in acetone, methylene chloride, a water-acetone mixture, and a soil-based mixture were applied in an ex-vivo pig-skin-flap model (n = 4-5/treatment). Dermal absorption (0.11-0.66%, 8 hr) and penetration (1.14-2.48%) varied according to exposure conditions. Acetone and methylene chloride vehicles differed in absorption profiles and skin penetration patterns but were similar in absorption amounts. Adding water to the acetone did not change absorption but did alter the penetration pattern. The non-occluded soil-based mixture showed more absorption than did the liquid vehicles (p0.29%, 8 hr) and penetration (2.48-->1.11%). In conclusion, dermal absorption data from liquid-organic or aqueousorganic mixtures may underestimate the risk of exposure to TCB-contaminated soil. JF - International journal of occupational and environmental health AU - Qiao, G AU - Riviere, J E AD - NIOSH, Centers for Disease Control, Morgantown, WV 26505-2888, USA. gaq1@cdc.gov PY - 2000 SP - 127 EP - 137 VL - 6 IS - 2 SN - 1077-3525, 1077-3525 KW - Pharmaceutical Vehicles KW - 0 KW - Soil Pollutants KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Swine KW - Animals KW - Soil Pollutants -- metabolism KW - Linear Models KW - Pharmacokinetics KW - Female KW - Skin -- drug effects KW - Skin Absorption KW - Polychlorinated Biphenyls -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71139184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Dermal+absorption+and+tissue+disposition+of+3%2C3%27%2C4%2C+4%27-tetrachlorobiphenyl+%28TCB%29+in+an+ex-vivo+pig+model%3A+assessing+the+impact+of+dermal+exposure+variables.&rft.au=Qiao%2C+G%3BRiviere%2C+J+E&rft.aulast=Qiao&rft.aufirst=G&rft.date=2000-04-01&rft.volume=6&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-24 N1 - Date created - 2000-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship between NAT1 genotype and phenotype in a Japanese population. AN - 71119719; 10803678 AB - NAT1, which biotransforms many carcinogens, is genetically polymorphic. This polymorphism has been postulated as a mechanism for susceptibility differences in cancer, possibly due to NAT1 activity differences. However, the relationship between NAT1 genotype and phenotype is not clear. In our study of 110 Japanese, the frequency of the NAT1*10 allele (0.53, 95% confidence interval 0.46-0.59) was higher than others have observed in Caucasians (0.16). From genotype frequency studies, 26.4% of the subjects belonged to the NAT1*10/*10 genotype, 53.6% to the NAT1*4/*10 genotype and 20% to the NAT1*4/*4 genotype. Neither NAT1*3 nor NAT1*11 genotype was seen in these subjects. In female subjects, we found higher NAT1 activity in NAT1*4/*10 subjects than in NAT1*4/*4 subjects (n = 49; 2.63 versus 2.16 nmol/min/mg protein). NAT1 activity-difference between NAT1*4/*10 and NAT1*10/*10 was not statistically significant. Thus, not only the presence of NAT1*10 allele, but also other factors are suspected of increasing NAT1 activities. After full sequencing of 10 subjects, five individuals having the highest activities and five individuals having the lowest activities, we found NAT1*18A and NAT1*18B to be in the high activity group and the low activity group, respectively. The genotypes containing these variants were heterozygous, i.e. NAT1*4/*18A and NAT1*4/*18B. Due to rare frequencies of these variants, they cannot be considered as other effective, genetic factors on NAT1 activity. Age and tobacco smoking did not affect the relationship between NAT1 genotype and phenotype. JF - Pharmacogenetics AU - Yang, M AU - Katoh, T AU - Delongchamp, R AU - Ozawa, S AU - Kohshi, K AU - Kawamoto, T AD - Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arizona 72079, USA. myang@nctr.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 225 EP - 232 VL - 10 IS - 3 SN - 0960-314X, 0960-314X KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - 4-Aminobenzoic Acid KW - TL2TJE8QTX KW - Index Medicus KW - Sex Factors KW - Gene Frequency KW - Humans KW - Neoplasms -- epidemiology KW - Aged KW - Sequence Analysis, DNA KW - Asian Continental Ancestry Group -- genetics KW - 4-Aminobenzoic Acid -- metabolism KW - Phenotype KW - Genotype KW - Smoking KW - Alleles KW - Aged, 80 and over KW - Adult KW - Lymphocytes -- enzymology KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Japan KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- metabolism KW - Isoenzymes -- metabolism KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71119719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics&rft.atitle=Relationship+between+NAT1+genotype+and+phenotype+in+a+Japanese+population.&rft.au=Yang%2C+M%3BKatoh%2C+T%3BDelongchamp%2C+R%3BOzawa%2C+S%3BKohshi%2C+K%3BKawamoto%2C+T&rft.aulast=Yang&rft.aufirst=M&rft.date=2000-04-01&rft.volume=10&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics&rft.issn=0960314X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-13 N1 - Date created - 2000-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Women's health and the environment: innovations in science and policy. AN - 71067886; 10787222 AB - Current scientific findings indicate that environmental factors affect women's health. Specifically, evidence has accumulated on the effects of the environment on reproductive health, cancer, injury, respiratory problems, autoimmune diseases, and other health problems. To review the current state of the science and policies related to women's health and the environment, the Federal Interagency Working Group on Women's Health and the Environment of the Department of Health and Human Services and the Society for Women's Health Research jointly sponsored a conference in 1998 entitled Women's Health and the Environment: Innovations in Science and Policy. The aim of the conference was to provide a forum for scientists to share recent findings, promising avenues of research, methodological barriers, and data gaps about women's susceptibility to environmental agents. The conference generated 22 recommendations for policy, 17 recommendations for communication and training, and 48 recommendations for research to be considered by the federal government. The purpose of this review is to bring to the attention of the scientific community and policymakers the breadth of the women's health implications associated with environmental factors by highlighting key research findings presented at the conference. This review summarizes the current status of science in women's health, it describes relevant activities by the federal government, and it suggests recommendations for future research and policy initiatives in the context of women's health and the environment. JF - Journal of women's health & gender-based medicine AU - Haynes, S G AU - Lynch, B S AU - Biegel, R AU - Malliou, E AU - Rudick, J AU - Sassaman, A P AD - Office on Women's Health, U.S. Department of Health and Human Services, Washington, DC 20201, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 245 EP - 273 VL - 9 IS - 3 SN - 1524-6094, 1524-6094 KW - Index Medicus KW - Humans KW - Practice Guidelines as Topic KW - Female KW - Women's Health KW - Environmental Exposure -- legislation & jurisprudence KW - Health Policy -- legislation & jurisprudence KW - Health Policy -- trends KW - Environmental Exposure -- adverse effects KW - Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71067886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%26+gender-based+medicine&rft.atitle=Women%27s+health+and+the+environment%3A+innovations+in+science+and+policy.&rft.au=Haynes%2C+S+G%3BLynch%2C+B+S%3BBiegel%2C+R%3BMalliou%2C+E%3BRudick%2C+J%3BSassaman%2C+A+P&rft.aulast=Haynes&rft.aufirst=S&rft.date=2000-04-01&rft.volume=9&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%26+gender-based+medicine&rft.issn=15246094&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-23 N1 - Date created - 2000-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitation of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography-mass spectrometry. AN - 71051824; 10775389 AB - Little is known about the possible health effects associated with inhaling alkenylbenzenes through cigarette smoking, even though these flavor-related compounds have known toxic effects in animals. We developed a rapid and sensitive solid-phase extraction (SPE) method to quantify seven alkenylbenzenes and piperonal in mainstream cigarette smoke particulate. The smoke particulate fraction of a single cigarette was collected on Cambridge filter pads, solvent extracted, concentrated, purified with SPE, and analyzed by selected ion monitoring gas chromatography-mass spectrometry. We positively identified and quantified five alkenylbenzenes compounds (eugenol, isoeugenol, methyleugenol myristicin, and elemicin) and piperonal in the smoke particulate from eight U.S. brands with mean levels (measured in triplicate) ranging from 6.6 to 4210 ng per cigarette. Additionally, complete blocking of nearly invisible ventilation holes in the cigarette filter increased 2- to 7-fold the percent transfer of alkenylbenzenes from tobacco to the particulate fraction of mainstream smoke. JF - Journal of agricultural and food chemistry AU - Stanfill, S B AU - Ashley, D L AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA 30341-3724, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 1298 EP - 1306 VL - 48 IS - 4 SN - 0021-8561, 0021-8561 KW - Alkenes KW - 0 KW - Benzaldehydes KW - Benzene Derivatives KW - Benzodioxoles KW - Benzyl Compounds KW - Dioxolanes KW - Smoke KW - Pyrogallol KW - 01Y4A2QXY0 KW - myristicin KW - 04PD6CT78W KW - Eugenol KW - 3T8H1794QW KW - elemicin KW - 487-11-6 KW - piperonal KW - KE109YAK00 KW - Safrole KW - RSB34337V9 KW - Index Medicus KW - Gas Chromatography-Mass Spectrometry -- methods KW - Benzaldehydes -- analysis KW - Eugenol -- analysis KW - Dioxolanes -- analysis KW - Pyrogallol -- analysis KW - Taste KW - Safrole -- analysis KW - Pyrogallol -- analogs & derivatives KW - Plants, Toxic KW - Tobacco KW - Smoke -- analysis KW - Benzene Derivatives -- analysis KW - Alkenes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71051824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Quantitation+of+flavor-related+alkenylbenzenes+in+tobacco+smoke+particulate+by+selected+ion+monitoring+gas+chromatography-mass+spectrometry.&rft.au=Stanfill%2C+S+B%3BAshley%2C+D+L&rft.aulast=Stanfill&rft.aufirst=S&rft.date=2000-04-01&rft.volume=48&rft.issue=4&rft.spage=1298&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-19 N1 - Date created - 2000-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fire- and flame-related occupational fatalities in the United States, 1980-1994. AN - 71049589; 10774512 AB - The National Traumatic Occupational Fatalities surveillance system recorded 1518 fire- and flame-related occupational fatalities among the civilian workforce in the United States between 1980 and 1994. The fatalities resulted from 1221 separate incidents, of which 122 involved more than one victim and accounted for 419 of 1518 deaths. Nearly 4 of 10 fatalities resulting from a multiple-victim fire were workers in the manufacturing industry. Similarly, the highest frequency of fatalities in single-victim events, over one fourth, were in manufacturing. For one fourth of the fatalities within each event category, the usual occupation of the deceased was a precision production, craft, and repair worker. Although this study sheds light on selected characteristics of these fatalities, additional research on the causal factors associated with single- and multiple-victim events is needed to present specific recommendations for prevention efforts. JF - Journal of occupational and environmental medicine AU - Biddle, E A AU - Hartley, D AD - Surveillance and Field Investigations Branch, National Institute for Occupational Safety and Health, Morgantown, W.V. 26505-2888, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 430 EP - 437 VL - 42 IS - 4 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Occupations KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Age Distribution KW - Accidents, Occupational -- prevention & control KW - Accidents, Occupational -- mortality KW - Fires -- statistics & numerical data KW - Fires -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71049589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Fire-+and+flame-related+occupational+fatalities+in+the+United+States%2C+1980-1994.&rft.au=Biddle%2C+E+A%3BHartley%2C+D&rft.aulast=Biddle&rft.aufirst=E&rft.date=2000-04-01&rft.volume=42&rft.issue=4&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-14 N1 - Date created - 2000-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Couriers of asthma: antigenic proteins in natural rubber latex. AN - 71048118; 10769347 AB - Natural rubber latex (NRL) is a milky, white liquid containing the polymer cis-1,4-polyisoprene, derived from the laticifer cells of the rubber tree, Hevea brasiliensis. Reports of allergic reactions to NRL, ranging in severity from skin rashes to anaphylaxis and death, have been increasing. High rates of latex allergy are seen in children with spina bifida. Healthcare workers, especially those who frequently use powdered latex medical gloves, can develop NRL allergy and asthma, often resulting in considerable disability. Atopy and, possibly, pre-existing dermatitis predispose to sensitization and allergic symptoms. NRL protein antigens are found in many NRL products and also have been shown to bind to cornstarch glove-donning powders. Of the approximately 240 polypeptides in NRL, nearly 60 are antigenic, and nine have been identified and registered (Hev b 1&ndash9). Many natural latex antigens share epitopes with structural proteins and enzymes from other plant species. Current knowledge indicates that proposed reductions in total glove protein and limitations on the use of powder on NRL gloves are likely to result in a decline in the prevalence and severity of NRL allergies among healthcare workers. JF - Occupational medicine (Philadelphia, Pa.) AU - Petsonk, E L AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. PY - 2000 SP - 421 EP - 430 VL - 15 IS - 2 SN - 0885-114X, 0885-114X KW - Antigens KW - 0 KW - Latex KW - Plant Proteins KW - Index Medicus KW - Sensitivity and Specificity KW - Latex -- adverse effects KW - Environmental Monitoring KW - Dermatitis, Allergic Contact -- etiology KW - Humans KW - Dermatitis, Allergic Contact -- therapy KW - Antigens -- analysis KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Latex Hypersensitivity -- diagnosis KW - Hypersensitivity, Immediate -- immunology KW - Plant Proteins -- immunology KW - Occupational Diseases -- immunology KW - Plant Proteins -- analysis KW - Plant Proteins -- adverse effects KW - Hypersensitivity, Immediate -- chemically induced KW - Latex Hypersensitivity -- immunology KW - Occupational Diseases -- chemically induced KW - Hypersensitivity, Immediate -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71048118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Couriers+of+asthma%3A+antigenic+proteins+in+natural+rubber+latex.&rft.au=Petsonk%2C+E+L&rft.aulast=Petsonk&rft.aufirst=E&rft.date=2000-04-01&rft.volume=15&rft.issue=2&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-23 N1 - Date created - 2000-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is specific antibody determination diagnostic for asthma attributable to low-molecular-weight agents? AN - 71045539; 10769344 AB - It is important to understand a medical testís performance characteristics, so that it can be used appropriately. Performance characteristics of tests for antibodies specific to low-molecular-weight (LMW) agents in predicting asthma caused by these agents differ in the study population. In general, currently published data supporting the use of tests to detect specific IgE and IgG to LMW agents in the diagnosis of occupational asthma is limited and inconclusive. However, a few general statements can be made. The most promising results have been achieved for agents such as acid anhydrides and platinum salts, where specific IgE responses appear to play a significant pathogenic role in causing occupational asthma. Results have been less promising for agents such as isocyanates and plicatic acid, for which antibody responses do not appear to underlie the development of asthma in most individuals. In the case of isocyanates, determination of antigen-specific IgG might have some utility as a biomarker of exposure. JF - Occupational medicine (Philadelphia, Pa.) AU - Weissman, D N AU - Lewis, D M AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. PY - 2000 SP - 385 EP - 398 VL - 15 IS - 2 SN - 0885-114X, 0885-114X KW - Biomarkers KW - 0 KW - Immunoglobulins KW - Inorganic Chemicals KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Patch Tests KW - Predictive Value of Tests KW - Molecular Weight KW - Radioallergosorbent Test KW - Cross-Sectional Studies KW - Biomarkers -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Occupational Exposure -- adverse effects KW - Data Collection KW - Female KW - Male KW - Occupational Exposure -- analysis KW - Occupational Diseases -- diagnosis KW - Immunoglobulins -- analysis KW - Antibody Specificity KW - Occupational Diseases -- immunology KW - Inorganic Chemicals -- adverse effects KW - Asthma -- diagnosis KW - Asthma -- chemically induced KW - Occupational Diseases -- chemically induced KW - Environmental Monitoring -- methods KW - Inorganic Chemicals -- chemistry KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71045539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Is+specific+antibody+determination+diagnostic+for+asthma+attributable+to+low-molecular-weight+agents%3F&rft.au=Weissman%2C+D+N%3BLewis%2C+D+M&rft.aulast=Weissman&rft.aufirst=D&rft.date=2000-04-01&rft.volume=15&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-23 N1 - Date created - 2000-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Equivalence and noninferiority trials. AN - 71009410; 10740125 JF - American heart journal AU - Siegel, J P AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. siegel@cber.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - S166 EP - S170 VL - 139 IS - 4 SN - 0002-8703, 0002-8703 KW - Cardiovascular Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Data Interpretation, Statistical KW - Therapeutic Equivalency KW - Cardiovascular Agents -- therapeutic use KW - Cardiovascular Agents -- adverse effects KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71009410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Equivalence+and+noninferiority+trials.&rft.au=Siegel%2C+J+P&rft.aulast=Siegel&rft.aufirst=J&rft.date=2000-04-01&rft.volume=139&rft.issue=4&rft.spage=S166&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-01 N1 - Date created - 2000-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of maternal exposure to flaxseed on spermatogenesis in F(1) generation rats. AN - 71007701; 10722886 AB - Pregnant Sprague-Dawley rats were exposed to a flaxseed (20 or 40%), flaxmeal (13 or 26%) or standard NIH AIN-93 (0% flaxseed control) diet throughout gestation and until their offspring were weaned. After weaning, F(1) generation males were placed in the same diet treatment groups as their mothers for 70 days. Statistically significant differences were not observed between either low-dose or high-dose flaxseed and flaxmeal-treated animals and the 0% flaxseed control animals for testis weights, homogenization resistant spermatid counts, daily sperm production rates, epididymal weights, seminal vesicle weights, seminiferous tubule fluid testosterone concentrations and the percentage of sperm abnormalities. The following statistically significant differences were observed when treated groups and the 0% flaxseed control groups were compared: (1) increases in serum LH in the 20% and 40% flaxseed treatment groups and in serum LH and testosterone in the 26% flaxmeal treatment group; (2) increases in the cauda epididymal weight from the 20% and 40% flaxseed groups; (3) increases in cauda epididymal sperm numbers/g epididymis from the 20% and 40% flaxseed and the 13% and 26% flaxmeal treatment groups; (4) a decrease in prostatic weight from the 20% flaxseed and 13% and 26% flaxmeal treatment groups. Prostate weight in the 40% flaxseed treatment group was lower but not statistically significantly different than the 0% flaxseed control group. Histological effects on spermatogenesis were not observed in either the control group, flaxmeal or the flaxseed treated groups. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sprando, R L AU - Collins, T F AU - Black, T N AU - Olejnik, N AU - Rorie, J I AU - Scott, M AU - Wiesenfeld, P AU - Babu, U S AU - O'Donnell, M AD - Division of Toxicological Research, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. rls@cfsan.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 325 EP - 334 VL - 38 IS - 4 SN - 0278-6915, 0278-6915 KW - Testosterone KW - 3XMK78S47O KW - Luteinizing Hormone KW - 9002-67-9 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Radioimmunoassay KW - Pregnancy KW - Rats KW - Maternal-Fetal Exchange KW - Rats, Sprague-Dawley KW - Testosterone -- blood KW - Luteinizing Hormone -- blood KW - Diet KW - Female KW - Male KW - Organ Size -- drug effects KW - Flax -- toxicity KW - Genitalia, Male -- drug effects KW - Genitalia, Male -- pathology KW - Genitalia, Male -- growth & development KW - Spermatogenesis -- drug effects KW - Seeds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71007701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=The+effect+of+maternal+exposure+to+flaxseed+on+spermatogenesis+in+F%281%29+generation+rats.&rft.au=Sprando%2C+R+L%3BCollins%2C+T+F%3BBlack%2C+T+N%3BOlejnik%2C+N%3BRorie%2C+J+I%3BScott%2C+M%3BWiesenfeld%2C+P%3BBabu%2C+U+S%3BO%27Donnell%2C+M&rft.aulast=Sprando&rft.aufirst=R&rft.date=2000-04-01&rft.volume=38&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-02 N1 - Date created - 2000-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An FDA perspective on antiarrhythmic drugs in phase II trials. AN - 71005078; 10740131 JF - American heart journal AU - Lipicky, R AD - Division of Cardio-Renal Drug Products, Food and Drug Administration, Rockville, MD 20852, USA. lipicky@cder.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - S197 EP - S199 VL - 139 IS - 4 SN - 0002-8703, 0002-8703 KW - Anti-Arrhythmia Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Data Interpretation, Statistical KW - Bias (Epidemiology) KW - Research Design KW - United States Food and Drug Administration KW - Clinical Trials, Phase II as Topic -- statistics & numerical data KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71005078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=An+FDA+perspective+on+antiarrhythmic+drugs+in+phase+II+trials.&rft.au=Lipicky%2C+R&rft.aulast=Lipicky&rft.aufirst=R&rft.date=2000-04-01&rft.volume=139&rft.issue=4&rft.spage=S197&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-01 N1 - Date created - 2000-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expanded analysis of injury mortality among unionized construction workers. AN - 70959150; 10706748 AB - To evaluate the utility of expanding the number and precision of injury categories used in previous occupational mortality studies, this study reanalyzed data from four previous studies of unionized construction workers (construction laborers, ironworkers, sheet metal workers, and operating engineers), by expanding the number of injury categories from 6 to 33. Proportionate mortality ratios (PMRs) were computed using the distribution of deaths from the National Occupational Mortality Surveillance System, a mortality surveillance system from 28 states, as a comparison. A blue collar comparison group was also used in additional analyses to adjust for socioeconomic and other factors. This reanalysis identified significantly elevated PMRs in at least one of the four worker groups for falls, motor vehicle crashes, machinery incidents, electrocutions, being struck by falling objects, being struck by flying objects, explosions, suffocation, and water transport incidents. Limiting the comparison population to deaths among blue collar workers did not change the results substantially. This study demonstrates that increasing the precision of categories of death from injury routinely used in mortality studies will provide improved information to guide prevention. Am. J. Ind. Med. 37:364-373, 2000. Published 2000 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Chen, G X AU - Johnston, J J AU - Alterman, T AU - Burnett, C AU - Steenland, K AU - Stern, F AU - Halperin, W AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 364 EP - 373 VL - 37 IS - 4 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - United States KW - Accidents, Traffic -- mortality KW - Humans KW - Chi-Square Distribution KW - Drowning -- mortality KW - Aged KW - Explosions KW - Population Surveillance KW - Socioeconomic Factors KW - Engineering KW - Accidental Falls -- mortality KW - Aged, 80 and over KW - Adult KW - Confidence Intervals KW - Middle Aged KW - Accidents, Occupational -- mortality KW - Asphyxia -- mortality KW - Electric Injuries -- mortality KW - Adolescent KW - Metallurgy KW - Male KW - Female KW - Labor Unions KW - Wounds and Injuries -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70959150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Expanded+analysis+of+injury+mortality+among+unionized+construction+workers.&rft.au=Chen%2C+G+X%3BJohnston%2C+J+J%3BAlterman%2C+T%3BBurnett%2C+C%3BSteenland%2C+K%3BStern%2C+F%3BHalperin%2C+W&rft.aulast=Chen&rft.aufirst=G&rft.date=2000-04-01&rft.volume=37&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-30 N1 - Date created - 2000-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats. AN - 70937461; 10699658 AB - Methylphenidate and D-amphetamine are central nervous system stimulants that have been suggested to share certain behavioral and neurochemical effects. The current study was undertaken to determine whether methylphenidate and D-amphetamine have similar effects on the performance of a battery of complex operant tasks in rats. Thus, the effects of amphetamine (0.1-6.0 mg/kg, i.p.) and methylphenidate (1.12-18.0 mg/kg, i.p) on the performance of rats in three complex food-reinforced operant tasks were examined. The tasks (and the brain functions they are intended to model) included: (1) conditioned position responding (auditory/visual/position discrimination); (2) incremental repeated acquisition (learning); and (3) temporal response differentiation (time estimation). In addition, each of these tasks was paired with a progressive ratio task to assess drug effects on the rats' motivation to lever press for the food reinforcers used. Consistent with their effects in other behavioral paradigms, methylphenidate and D-amphetamine produced very similar patterns of disruption of the four tasks. Drug-induced changes in the endpoints of the progressive ratio task generally paralleled changes in the other three tasks, suggesting a major role for appetitive motivation in the effects of these agents. Several effects of these agents seen in the current study are consistent with their effects in children with attention-deficit-hyperactivity disorder. These data further validate the use of this battery of operant tasks for the characterization of pharmacological agents, and suggest that findings using these tasks may be predictive of what is seen in humans. JF - Behavioural brain research AU - Mayorga, A J AU - Popke, E J AU - Fogle, C M AU - Paule, M G AD - Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, HFT-132, Jefferson, AR 72079- 9502, USA. amayorga@nctr.fda.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 59 EP - 68 VL - 109 IS - 1 SN - 0166-4328, 0166-4328 KW - Catecholamines KW - 0 KW - Central Nervous System Stimulants KW - Methylphenidate KW - 207ZZ9QZ49 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Discrimination Learning -- drug effects KW - Injections, Intraperitoneal KW - Reaction Time -- drug effects KW - Animals KW - Catecholamines -- metabolism KW - Motivation KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Time Perception -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Orientation -- drug effects KW - Mental Recall -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Methylphenidate -- pharmacology KW - Attention -- drug effects KW - Amphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70937461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Similar+effects+of+amphetamine+and+methylphenidate+on+the+performance+of+complex+operant+tasks+in+rats.&rft.au=Mayorga%2C+A+J%3BPopke%2C+E+J%3BFogle%2C+C+M%3BPaule%2C+M+G&rft.aulast=Mayorga&rft.aufirst=A&rft.date=2000-04-01&rft.volume=109&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-03 N1 - Date created - 2000-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Influence of melatonin on immunotoxicity of cadmium. AN - 70929862; 10689101 AB - The results suggested that immunotoxicity induced by Cd was significantly restored or prevented by MLT. MLT (10 or 50 mg/kg) was orally administered to ICR mice daily for 28 consecutive days, and cadmium (Cd, as [Cd(AC)(2)]) was also administered at 25 mg/kg by the same route 2 h after the administration of MLT, and the normal mice were given vehicle. Within the Cd plus MLT-treated group, the body weight gains and relative thymus weights were significantly increased when compared with the treatment of Cd alone. The relative spleen and liver weights were increased by treatment of Cd alone, then restored to normal value by MLT treatment. Hemagglutination (HA) titer, primary IgM antibody response to SRBC, and secondary IgG antibody response to BSA was significantly increased with the Cd plus MLT-treated mice, as opposed to when compared with treatment of Cd alone. The NK cell and phagocytic activity used for evaluation of non-specific immunocompetence was significantly increased in Cd plus MLT-treated mice when compared with the treatment of Cd alone. The number of peripheral leukocytes was significantly increased in Cd plus MLT-treated mice when compared with treatment of Cd alone. JF - International journal of immunopharmacology AU - Kim, Y O AU - Ahn, Y K AU - Kim, J H AD - Immunotoxicology Division, Toxicology Department, National Institute Toxicological Research, Korea FDA, Eunpyung-Ku, Seoul, South Korea. okjutwo@yahoo.com Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 275 EP - 284 VL - 22 IS - 4 SN - 0192-0561, 0192-0561 KW - Immunoglobulin G KW - 0 KW - Immunoglobulin M KW - Cadmium KW - 00BH33GNGH KW - Melatonin KW - JL5DK93RCL KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Body Weight -- drug effects KW - Mice KW - Phagocytosis -- drug effects KW - Immunoglobulin M -- biosynthesis KW - Hemagglutination -- drug effects KW - Immunoglobulin G -- biosynthesis KW - Male KW - Leukocyte Count KW - Killer Cells, Natural -- immunology KW - Killer Cells, Natural -- drug effects KW - Melatonin -- pharmacology KW - Cadmium -- toxicity KW - Immunity -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70929862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Influence+of+melatonin+on+immunotoxicity+of+cadmium.&rft.au=Kim%2C+Y+O%3BAhn%2C+Y+K%3BKim%2C+J+H&rft.aulast=Kim&rft.aufirst=Y&rft.date=2000-04-01&rft.volume=22&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - The Outreach Sourcebook, Volume 6: Rural Health Demonstration Projects, 1996 to 1999. AN - 62320234; ED451001 AB - In 1996, the federal Office of Rural Health Policy awarded 3-year outreach demonstration grants to 25 projects to provide direct primary and preventive health care services to rural residents in 20 states. The grant program allows recipients to test innovative ideas against the challenges of rural health care delivery, such as provider shortages, geographic isolation, and uninsured or underinsured children and families. Recipients must form a consortium of three or more local and state agencies or institutions to work together toward project goals. All the projects in this funding cycle succeeded in their efforts, but the populations served and the models implemented were extremely diverse. Fourteen projects focused on the specific needs of infants, children, or adolescents. Among other populations, women were served specifically by 11 projects, minority groups (Hispanics, African Americans, Native Americans, or Amish) by 8 projects, and the elderly by 6 projects. Six projects focused their activities in rural schools. Eleven projects provided continuing education opportunities to health professionals. Health education, health promotion, or disease prevention were the focus of 11 projects, with topics such as substance abuse, smoking prevention, mental health, nutrition, and first aid. Descriptions of the 25 projects include population served, services provided, innovative features, results, potential for replication, plans for continued funding, and contact information. (Contains title and subject indexes, a glossary, and a project locator map.) (SV) Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 102 PB - Full text at Web site: ftp://ftp, hrsagov/ftp/ruralhealth/orhpvol6pdf KW - ERIC, Resources in Education (RIE) KW - Program Descriptions KW - Health Programs KW - Outreach Programs KW - Consortia KW - Federal Aid KW - Health Education KW - Rural Areas KW - Professional Continuing Education KW - Medical Education KW - Health Promotion KW - School Health Services KW - Health Services KW - Demonstration Programs KW - Access to Health Care KW - Community Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62320234?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Training Injury Control Practitioners: The Indian Health Service Model AN - 61297217; 200100669 AB - Consistent with its mission of "raising the health status of American Indian & Alaska Native people to the highest possible level," the Indian Health Service (IHS) created an innovative training program for federal & tribal employees practicing injury control. The model emphasizes training that is practical & can be applied immediately to community interventions. Many features of the IHS training model have broad applicability to other settings. These features include the use of experiential instruction, preceptors, & community case studies to train individuals from diverse cultural & educational backgrounds; educational strategies for employed adults; & courses that promote community empowerment. The development of IHS training courses are guided by community input, epidemiological data, advances in knowledge, & program evaluations. The success of the training model is evident in programs instituted by IHS Injury Prevention Specialist Fellowship graduates, & it is suggested that the model could be applied in a variety of other community-based settings; however, it is most relevant to programs that train individuals from diverse backgrounds who are not full-time students & programs that make community needs an organizational priority. 4 Tables, 1 Box, 2 Photos, 50 References. Adapted from the source document. JF - Future of Children AU - Smith, Richard J, III AU - Dellapenna, Alan J, Jr AU - Berger, Lawrence R AD - Office Public Health, Indian Health Service, Rockville, MD Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 175 EP - 188 VL - 10 IS - 1 SN - 1054-8289, 1054-8289 KW - Paraprofessional Workers KW - Prevention KW - Injuries KW - Government Agencies KW - Safety KW - Children KW - Job Training KW - American Indians KW - Adolescents KW - article KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61297217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+of+Children&rft.atitle=Training+Injury+Control+Practitioners%3A+The+Indian+Health+Service+Model&rft.au=Smith%2C+Richard+J%2C+III%3BDellapenna%2C+Alan+J%2C+Jr%3BBerger%2C+Lawrence+R&rft.aulast=Smith&rft.aufirst=Richard&rft.date=2000-04-01&rft.volume=10&rft.issue=1&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Future+of+Children&rft.issn=10548289&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - FCHIEW N1 - SubjectsTermNotLitGenreText - Children; Safety; Adolescents; Injuries; Prevention; American Indians; Government Agencies; Job Training; Paraprofessional Workers ER - TY - BOOK T1 - Federal activities addressing violence in schools AN - 59814110; 2000-0900010 AB - Identifies activities and projects of federal agencies and offices which address school violence prevention in school-associated settings; describes programs, methods of disseminating information, strategies for increasing collaborative efforts and future projects; with contact information; US. JF - United States Centers for Disease Control and Prevention, April 2000. AU - Barrios, Lisa C Y1 - 2000/04// PY - 2000 DA - April 2000 PB - United States Centers for Disease Control and Prevention KW - Youth -- Social aspects KW - School violence -- United States KW - Social service -- Work with youth KW - United States -- Social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59814110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Barrios%2C+Lisa+C&rft.aulast=Barrios&rft.aufirst=Lisa&rft.date=2000-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Federal+activities+addressing+violence+in+schools&rft.title=Federal+activities+addressing+violence+in+schools&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/nccdphp/dash/violence/index.htm LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Centers Disease Control and Prevention N1 - Document feature - il(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Longwall mining into pre-driven rooms AN - 52271386; 2001-010559 JF - Coal International AU - Oyler, David AU - Frith, Russell AU - Doliner, Dennis AU - Christopher, Mark Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 59 EP - 61, 63-64 PB - Trade Link Publications, Betchworth, Surrey VL - 248 IS - 2 SN - 1357-6941, 1357-6941 KW - mining KW - mines KW - failures KW - geologic hazards KW - underground mining KW - data processing KW - coal mines KW - international cooperation KW - production KW - rock mechanics KW - case studies KW - intrusions KW - dikes KW - longwall mining KW - data bases KW - faults KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52271386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coal+International&rft.atitle=Longwall+mining+into+pre-driven+rooms&rft.au=Oyler%2C+David%3BFrith%2C+Russell%3BDoliner%2C+Dennis%3BChristopher%2C+Mark&rft.aulast=Oyler&rft.aufirst=David&rft.date=2000-04-01&rft.volume=248&rft.issue=2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Coal+International&rft.issn=13576941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - PubXState - Surrey N1 - Document feature - illus. incl. 1 table, block diag., sect. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - case studies; coal mines; data bases; data processing; dikes; failures; faults; geologic hazards; international cooperation; intrusions; longwall mining; mines; mining; production; rock mechanics; underground mining ER - TY - JOUR T1 - Automated PC-network-based seismic monitoring systems applied to mining hazards research AN - 51163095; 2003-015274 JF - Seismological Research Letters AU - Swanson, P L AU - Anonymous Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 234 PB - Seismological Society of America, El Cerrito, CA VL - 71 IS - 2 SN - 0895-0695, 0895-0695 KW - mining KW - failures KW - technology KW - monitoring KW - geologic hazards KW - geophysical methods KW - data processing KW - information management KW - seismic methods KW - data management KW - computer programs KW - safety KW - mining geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51163095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seismological+Research+Letters&rft.atitle=Automated+PC-network-based+seismic+monitoring+systems+applied+to+mining+hazards+research&rft.au=Swanson%2C+P+L%3BAnonymous&rft.aulast=Swanson&rft.aufirst=P&rft.date=2000-04-01&rft.volume=71&rft.issue=2&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Seismological+Research+Letters&rft.issn=08950695&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seismological Society of America 2000; 95th annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - PubXState - CA N1 - Last updated - 2012-06-07 N1 - CODEN - EAQNAT N1 - SubjectsTermNotLitGenreText - computer programs; data management; data processing; failures; geologic hazards; geophysical methods; information management; mining; mining geology; monitoring; safety; seismic methods; technology ER - TY - JOUR T1 - Neurologic Function Among Termiticide Applicators Exposed to Chlorpyrifos AN - 18022161; 4711134 AB - Chlorpyrifos is a moderately toxic organophosphate pesticide. Houses and lawns in the United States receive a total of approximately 20 million annual chlorpyrifos treatments, and 82% of U.S. adults have detectable levels of a chlorpyrifos metabolite (3,5,6-trichloro-2-pyridinol; TCP) in the urine. The U.S. Environmental Protection Agency has estimated that there are 5,000 yearly reported cases of accidental chlorpyrifos poisoning, and approximately one-fourth of these cases exhibit symptoms. Organophosphates affect the nervous system, but there are few epidemiologic data on chlorpyrifos neurotoxicity. We studied neurologic function in 191 current and former termiticide applicators who had an average of 2.4 years applying chlorpyrifos and 2.5 years applying other pesticides, and we compared them to 189 nonexposed controls. The average urinary TCP level for 65 recently exposed applicators was 629.5 mu g/L, as compared to 4.5 mu g/L for the general U.S. population. The exposed group did not differ significantly from the nonexposed group for any test in the clinical examination. Few significant differences were found in nerve conduction velocity, arm/hand tremor, vibrotactile sensitivity, vision, smell, visual/motor skills, or neurobehavioral skills. The exposed group did not perform as well as the nonexposed group in pegboard turning tests and some postural sway tests. The exposed subjects also reported significantly more symptoms, including memory problems, emotional states, fatigue, and loss of muscle strength; our more quantitative tests may not have been adequate to detect these symptoms. Eight men who reported past chlorpyrifos poisoning had a pattern of low performance on a number of tests, which is consistent with prior reports of chronic effects of organophosphate poisoning. Overall, the lack of exposure effects on the clinical examination was reassuring. The findings for self-reported symptoms raise some concern, as does the finding of low performance for those reporting prior poisoning. Although this was a relatively large study based on a well-defined target population, the workers we studied may not be representative of all exposed workers, and caution should be exercised in generalizing our results. JF - Environmental Health Perspectives AU - Steenland, K AU - Dick, R B AU - Howell, R J AU - Chrislip, D W AU - Hines, C J AU - Reid, T M AU - Lehman, E AU - Laber, P AU - Krieg, EF Jr AU - Knott, C AD - National Institute for Occupational Safety and Health, Cincinnati (NIOSH), R13, 4676 Columbia Parkway, Cincinnati, OH 45226 USA, kns1@cdc.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 293 EP - 300 VL - 108 IS - 4 SN - 0091-6765, 0091-6765 KW - chronic exposure KW - man KW - chlorpyrifos KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Pesticides (organophosphorus) KW - Organophosphates KW - Pesticide applications KW - Chlorpyrifos KW - Neurotoxicity KW - Pesticides KW - Occupational exposure KW - H 5000:Pesticides KW - X 24132:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18022161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Neurologic+Function+Among+Termiticide+Applicators+Exposed+to+Chlorpyrifos&rft.au=Steenland%2C+K%3BDick%2C+R+B%3BHowell%2C+R+J%3BChrislip%2C+D+W%3BHines%2C+C+J%3BReid%2C+T+M%3BLehman%2C+E%3BLaber%2C+P%3BKrieg%2C+EF+Jr%3BKnott%2C+C&rft.aulast=Steenland&rft.aufirst=K&rft.date=2000-04-01&rft.volume=108&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Organophosphates; Pesticides; Occupational exposure; Neurotoxicity; Chlorpyrifos; Pesticides (organophosphorus); Pesticide applications ER - TY - JOUR T1 - A Pooled Analysis of the Iraqi and Seychelles Methylmercury Studies AN - 17668063; 4754543 AB - Several epidemiology studies have investigated the impact of maternal exposure to methylmercury (MeHg) on childhood development of the central nervous system (CNS). In the present report, data from the Iraqi episode that occurred in 1970 from contaminated grain are integrated with those from a more recent study of a population with a high fish intake in the Seychelles Islands. The latter study had many more subjects whose mercury hair levels that were much lower and more representative of levels typically found in consumers whose MeHg exposure is from fish. The age of onset of talking (AOT), the age of onset of walking (AOW) and a combined measure (CM) that integrated the two were used as common scales of MeHg effect for the two studies. The first step of the analyses involved the construction of separate two-dimensional cumulative frequency tables for each study for different groups spanning the range of hair levels and observed effect for each measure. Models were then fit to the values in the tables. After optimizing the fit of each model, a weighting algorithm that rewards for fit and penalizes for the number of parameters in the model was used to identify the best 200 models. The same algorithm was then used to assign a probability to each model in a probability tree. A two-dimensional Monte-Carlo simulation using the resulting function in combination with exposure values typical of U.S. consumers yielded predicted delays in AOT, AOW, and CM attributable to fish consumption in a variable and uncertain range of 0.000 to 1 day. JF - Human and Ecological Risk Assessment AU - Carrington, C D AU - Bolger, P M AD - U.S. Food and Drug Administration, Washington, DC, USA, cdc@cfsan.fda.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 323 EP - 340 PB - CRC Press LLC, 2000 Corporate Blvd., NW Boca Raton FL 33431 USA, [mailto:journals@crcpress.com], [URL:http://www.crcpress.com] VL - 6 IS - 2 SN - 1080-7039, 1080-7039 KW - maternal transfer KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Methylmercury KW - Food contamination KW - Pregnancy KW - Seafood KW - Infants KW - H 4000:Food and Drugs KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17668063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+and+Ecological+Risk+Assessment&rft.atitle=A+Pooled+Analysis+of+the+Iraqi+and+Seychelles+Methylmercury+Studies&rft.au=Carrington%2C+C+D%3BBolger%2C+P+M&rft.aulast=Carrington&rft.aufirst=C&rft.date=2000-04-01&rft.volume=6&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Human+and+Ecological+Risk+Assessment&rft.issn=10807039&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Seafood; Food contamination; Methylmercury; Infants; Pregnancy ER - TY - JOUR T1 - Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters AN - 17617084; 4753550 AB - Corynebacterium diphtheriae and Corynebacterium ulcerans use haemin and haemoglobin as essential sources of iron during growth in iron-depleted medium. C. diphtheriae and C. ulcerans mutants defective in haemin iron utilization were isolated and characterized. Four clones from a C. diphtheriae genomic library complemented several of the Corynebacteria haemin utilization mutants. The complementing plasmids shared an approximately 3 kb region, and the nucleotide sequence of one of the plasmids revealed five open reading frames that appeared to be organized in a single operon. The first three genes, which we have termed hmuT, hmuU and hmuV, shared striking homology with genes that are known to be required for haemin transport in Gram-negative bacteria and are proposed to be part of an ABC (ATP-binding cassette) transport system. The hmuT gene encodes a 37 kDa lipoprotein that is associated with the cytoplasmic membrane when expressed in Escherichi coli and C. diphtheriae. HmuT binds in vitro to haemin- and haemoglobin-agarose, suggesting that it is capable of binding both haemin and haemoglobin and may function as the haemin receptor in C. diphtheriae. This study reports the first genetic characterization of a transport system that is involved in the utilization of haemin and haemoglobin as iron sources by a Gram-positive bacterium. JF - Molecular Microbiology AU - Drazek, SE AU - Hammack, A C AU - Schmitt, P M AD - Laboratory of Bacterial Toxins, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 68 EP - 84 PB - Blackwell Science Ltd VL - 36 IS - 1 SN - 0950-382X, 0950-382X KW - genes KW - cDNA KW - amino acid sequence prediction KW - hemin KW - hmuT gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - ABC transporter KW - Nucleotide sequence KW - Corynebacterium diphtheriae KW - Corynebacterium ulcerans KW - Hemoglobin KW - Iron KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17617084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Corynebacterium+diphtheriae+genes+required+for+acquisition+of+iron+from+haemin+and+haemoglobin+are+homologous+to+ABC+haemin+transporters&rft.au=Drazek%2C+SE%3BHammack%2C+A+C%3BSchmitt%2C+P+M&rft.aulast=Drazek&rft.aufirst=SE&rft.date=2000-04-01&rft.volume=36&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1046%2Fj.1365-2958.2000.01818.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Corynebacterium diphtheriae; Corynebacterium ulcerans; Iron; Hemoglobin; ABC transporter; Nucleotide sequence DO - http://dx.doi.org/10.1046/j.1365-2958.2000.01818.x ER - TY - CONF T1 - Assessment of immunosuppressant drug carcinogenicity: Standard and alternative animal models AN - 17610347; 4745556 AB - Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this would mean that rodent carcinogenicity bioassays would be performed under most circumstances. Immunosuppressant drugs have presented unique challenges with respect to the issue of carcinogenicity bioassays. The pharmacological activity of therapeutic immunosuppressants is thought to make them highly likely to act as promoters/cocarcinogens, even in the absence of genotoxic activity. Thus, it is assumed that this class of drug would represent a carcinogenic hazard in the absence of confirmatory standard rodent bioassay data. In addition, rodents typically have been sensitive to the pharmacological/toxicological effects of immunosuppressants. It has proven to be difficult, therefore, to conduct life-time bioassays at doses reasonably equivalent to those that would be used clinically. For this and other reasons, alternative models might be more appropriate for risk assessment with this class of drugs. JF - Human & Experimental Toxicology AU - Hastings, K L Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 261 EP - 265 PB - Hodder Arnold, 338 Euston Road London NW1 3BH UK, [mailto:mary.attree@hodder.co.uk], [URL:http://www.arnoldpublishers.com] VL - 19 IS - 4 KW - immunosuppressive agents KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - Carcinogenicity testing KW - Animal models KW - Pharmaceutical industry KW - Immunosuppressive agents KW - Carcinogenicity KW - Pharmaceuticals KW - Toxicity testing KW - X 24221:Toxicity testing KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17610347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Assessment+of+immunosuppressant+drug+carcinogenicity%3A+Standard+and+alternative+animal+models&rft.au=Hastings%2C+K+L&rft.aulast=Hastings&rft.aufirst=K&rft.date=2000-04-01&rft.volume=19&rft.issue=4&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Clinical trial design for immunomodulatory biologics AN - 17561873; 4745557 AB - The immune system plays a central role in the pathogenesis of many clinically diverse disease states. Biologic therapeutics currently offer the greatest potential for disease-specific immunomodulation. JF - Human & Experimental Toxicology AU - Essayan, D M Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 255 EP - 256 PB - Stockton Press, Houndmills Basingstoke Hants RG21 6XS UK VL - 19 IS - 4 KW - man KW - Toxicology Abstracts KW - Immune system KW - Pharmaceuticals KW - Immunomodulation KW - Clinical trials KW - Side effects KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17561873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Clinical+trial+design+for+immunomodulatory+biologics&rft.au=Essayan%2C+D+M&rft.aulast=Essayan&rft.aufirst=D&rft.date=2000-04-01&rft.volume=19&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603721&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Dermatotoxicokinetic Modeling of p-Nitrophenol and Its Conjugation Metabolite in Swine following Topical and Intravenous Administration AN - 17539852; 4716687 AB - The development of a dermatotoxicokinetic (dTK) model for p-nitrophenol (PNP), a common metabolite from a variety of compounds and a biomarker of organophosphate (OP) insecticide exposure, may facilitate the kinetic modeling and risk assessment strategy for its parent compounds. In order to quantify and then clarify in vivo-in vitro correlation of PNP disposition, multicompartment kinetic models were formulated. Female weanling pigs were dosed with [ super(14)C]PNP intravenously (150 mu g in ethanol, n = 4) or topically onto non-occluded abdominal skin (300 mu g/7.5cm super(2) in ethanol, n = 4). PNP and p-nitrophenyl- beta -D-glucuronide (PNP-G) profiles were determined in plasma and urine in addition to total super(14)C quantitation in many other samples. Disposition parameters (rate constants, F sub(top), T sub(1/2), T sub(1/2Ka), AUC, Vss, C sub(lp), MAT, and MRT) and the simulated chemical mass-time profiles on the dosed skin surface and in the local, systemic, and excretory compartments were also determined. Total recoveries of 97.17 plus or minus 4.18% and 99.80 plus or minus 2.41% were obtained from topical and intravenous experiments, respectively. Ninety-six hours after topical and intravenous application, 70.92 plus or minus 9.72% and 98.65 plus or minus 2.43% of the dose were excreted via urine, and 0.55 plus or minus 0.16% and 0.51 plus or minus 0.10% via the fecal route, respectively. Peak excretion rate and time were also determined. It was suggested by experimental observation and modeling that urinary super(14)C excretion correlates with the systemic tissue depletion profile well and may be used as a biomarker of PNP exposure. This study also supports the strategy of using urinary PNP as a biomonitoring tool for OP pesticide exposure, although some precautions have to be taken. The strategy used in this study will be useful in comprehensive dTK modeling in dermal risk assessment and transdermal drug delivery. JF - Toxicological Sciences AU - Qiao, G L AU - Chang, S K AU - Brooks, J D AU - Riviere, JE AD - National Institute for Occupational Safety and Health (NIOSH), CDC, Morgantown, West Virginia 26505, USA Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 284 EP - 294 VL - 54 IS - 2 SN - 1096-6080, 1096-6080 KW - toxicokinetics KW - p-Nitrophenol KW - pigs KW - Toxicology Abstracts KW - Pollution monitoring KW - Pesticides (organophosphorus) KW - Organophosphorus compounds KW - Insecticides KW - Skin KW - Urine KW - Feces KW - X 24133:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17539852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Dermatotoxicokinetic+Modeling+of+p-Nitrophenol+and+Its+Conjugation+Metabolite+in+Swine+following+Topical+and+Intravenous+Administration&rft.au=Qiao%2C+G+L%3BChang%2C+S+K%3BBrooks%2C+J+D%3BRiviere%2C+JE&rft.aulast=Qiao&rft.aufirst=G&rft.date=2000-04-01&rft.volume=54&rft.issue=2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Insecticides; Pesticides (organophosphorus); Organophosphorus compounds; Urine; Feces; Pollution monitoring ER - TY - JOUR T1 - Regulation by protein kinase of phagocytosis of Mycobacterium leprae by macrophages AN - 17517727; 4698484 AB - Mycobacterium leprae multiplies within host macrophages. The mechanism of internalisation of the bacteria by the phagocytic cells is unknown. In this study, M. leprae was purified from the foot pads of experimentally infected nu/nu mice. Peritoneal macrophages were harvested from BALB/c mice or C57 beige (bg/bg) mice. The effect of protein kinase inhibitors (erbstatin, genistein or staurosporine for BALB/c and bg/bg mice, plus herbimycin for bg/bg mice) on phagocytosis of the mycobacteria by the macrophage monolayers was tested. The untreated (control) macrophages phagocytosed M. leprae. Phagocytosis by BALB/c macrophages was inhibited by erbstatin and staurosporine but not by genistein; all the protein kinase inhibitors prevented uptake of M. leprae by bg/bg cells. The results demonstrate that protein kinase regulates phagocytosis of M. leprae by macrophages. The mechanism might prove to be a rational drug target for mycobacteria that multiply intracellularly. JF - Journal of Medical Microbiology AU - Prabhakaran, K AU - Harris, E B AU - Randhawa, B AD - US Public Health Service, GWL Hansen's Disease Center at Louisiana State University, PO Box 25072, Baton Rouge, LA 70894-5072, USA, kprabhal@hotmail.com Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 339 EP - 342 VL - 49 IS - 4 SN - 0022-2615, 0022-2615 KW - BALB/c mice KW - C57 beige mice KW - erbstatin KW - genistein KW - protein kinase inhibitor KW - staurosporine KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Mycobacterium leprae KW - Protein kinase KW - Phagocytosis KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17517727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Microbiology&rft.atitle=Regulation+by+protein+kinase+of+phagocytosis+of+Mycobacterium+leprae+by+macrophages&rft.au=Prabhakaran%2C+K%3BHarris%2C+E+B%3BRandhawa%2C+B&rft.aulast=Prabhakaran&rft.aufirst=K&rft.date=2000-04-01&rft.volume=49&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Microbiology&rft.issn=00222615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium leprae; Phagocytosis; Protein kinase; Macrophages ER - TY - JOUR T1 - Specificity of human antibodies reactive with pneumococcal C polysaccharide AN - 17516602; 4704213 AB - Antibodies reactive with C polysaccharide (PS) were found in healthy adults, pneumococcal patients, and vaccinees. These antibodies were not directed to the phosphocholine determinant of the C PS, as they appear to be in mice, since the human antibodies were inhibitable only with C PS. We found another population of phosphocholine-specific antibodies inhibitable only by phosphocholine and related compounds. JF - Infection and Immunity AU - Frasch, CE AU - Concepcion, N F AD - Division of Bacterial Products, CBER, 1401 Rockville Pike, HFM-428, Rockville, MD 20852, USA, frasch@cber.fda.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 2333 EP - 2337 VL - 68 IS - 4 SN - 0019-9567, 0019-9567 KW - man KW - immunology KW - serum KW - Phosphocholine KW - Polysaccharide C KW - Streptococcus pneumoniae KW - phosphocholine KW - polysaccharides KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - Antigenic determinants KW - Vaccines KW - Antibody response KW - Immunization KW - Antigen-antibody interactions KW - Epitopes KW - Immunoglobulins KW - J 02832:Antigenic properties and virulence KW - F 06801:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17516602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Specificity+of+human+antibodies+reactive+with+pneumococcal+C+polysaccharide&rft.au=Frasch%2C+CE%3BConcepcion%2C+N+F&rft.aulast=Frasch&rft.aufirst=CE&rft.date=2000-04-01&rft.volume=68&rft.issue=4&rft.spage=2333&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.4.2333-2337.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Antibody response; Vaccines; Antibodies; Epitopes; Enzyme-linked immunosorbent assay; Antigen-antibody interactions; Immunoglobulins; Immunization; Antigenic determinants DO - http://dx.doi.org/10.1128/IAI.68.4.2333-2337.2000 ER - TY - JOUR T1 - Purified lipopolysaccharide from Francisella tularensis live vaccine strain (LVS) induces protective immunity against LVS infection that requires B cells and gamma interferon AN - 17516287; 4704096 AB - Previous results have demonstrated that nonspecific protective immunity against lethal Francisella tularensis live vaccine strain (LVS) or Listeria monocytogenes infection can be stimulated either by sublethal infection with bacteria or by treatment with bacterial DNA given 3 days before lethal challenge. Here we characterize the ability of purified lipopolysaccharide (LPS) from F. tularensis LVS to stimulate similar early protective immunity. Treatment of mice with surprisingly small amounts of LVS LPS resulted in very strong and long-lived protection against lethal LVS challenge within 2 to 3 days. Despite this strong protective response, LPS purified from F. tularensis LVS did not activate murine B cells for proliferation or polyclonal immunoglobulin secretion, nor did it activate murine splenocytes for secretion of interleukin-4 (IL-4), IL-6, IL-12, or gamma interferon (IFN- gamma ). Immunization of mice with purified LVS LPS induced a weak specific anti-LPS immunoglobulin M (IgM) response and very little IgG; however, infection of mice with LVS bacteria resulted in vigorous IgM and IgG, particularly IgG2a, anti-LPS antibody responses. Studies using various immunodeficient mouse strains, including LPS-hyporesponsive C3H/HeJ mice, mu MT super(-) (B-cell-deficient) knockout mice, and IFN- gamma -deficient mice, demonstrated that the mechanism of protection does not involve recognition through the Lps super(n) gene product; nonetheless, protection was dependent on B cells as well as IFN- gamma . JF - Infection and Immunity AU - Dreisbach, V C AU - Cowley, S AU - Elkins, K L AD - DBP/CBER/FDA, 1401 Rockville Pike, HFM 431, Bethesda, MD 20852, USA, elkins@cber.fda.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 1988 EP - 1996 VL - 68 IS - 4 SN - 0019-9567, 0019-9567 KW - C3H/HeJ mice KW - immunology KW - Francisella tularensis KW - gamma -Interferon KW - interleukins KW - lipopolysaccharides KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - g-Interferon KW - Lymphocytes B KW - Animal models KW - Antibody response KW - ^g-Interferon KW - Live KW - Lipopolysaccharides KW - Immune response KW - Vaccines KW - Immunoglobulin M KW - Immunoglobulins KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization KW - F 06775:Chemokines KW - F 06749:Function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17516287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Purified+lipopolysaccharide+from+Francisella+tularensis+live+vaccine+strain+%28LVS%29+induces+protective+immunity+against+LVS+infection+that+requires+B+cells+and+gamma+interferon&rft.au=Dreisbach%2C+V+C%3BCowley%2C+S%3BElkins%2C+K+L&rft.aulast=Dreisbach&rft.aufirst=V&rft.date=2000-04-01&rft.volume=68&rft.issue=4&rft.spage=1988&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.4.1988-1996.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Francisella tularensis; Vaccines; Lymphocytes B; Immunoglobulin M; Live; Immune response; Animal models; Immunoglobulins; Antibody response; Lipopolysaccharides; ^g-Interferon DO - http://dx.doi.org/10.1128/IAI.68.4.1988-1996.2000 ER - TY - JOUR T1 - Selective accumulation may account for shellfish-associated viral illness AN - 17514163; 4704263 AB - From 1991 through 1998, 1,266 cases of shellfish-related illnesses were attributed to Norwalk-like viruses. Seventy-eight percent of these illnesses occurred following consumption of oysters harvested from the Gulf Coast during the months of November through January. This study investigated the ability of eastern oysters (Crassostrea virginica) to accumulate indicator microorganisms (i.e., fecal coliforms, Escherichia coli, Clostridium perfringens, and F super(+) coliphage) from estuarine water. One-week trials over a 1-year period were used to determine if these indicator organisms could provide insight into the seasonal occurrence of these gastrointestinal illnesses. The results demonstrate that oysters preferentially accumulated F super(+) coliphage, an enteric viral surrogate, to their greatest levels from late November through January, with a concentration factor of up to 99-fold. However, similar increases in accumulation of the other indicator microorganisms were not observed. These findings suggest that the seasonal occurrence of shellfish-related illnesses by enteric viruses is, in part, the result of seasonal physiological changes undergone by the oysters that affect their ability to accumulate viral particles from estuarine waters. JF - Applied and Environmental Microbiology AU - Burkhardt, W III AU - Calci, K R AD - US Food and Drug Administration, 1 Iberville Dr., P.O. Box 158, Dauphin Island, AL 36528-0158, USA, Wburkhar@cfsan.fda.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 1375 EP - 1378 VL - 66 IS - 4 SN - 0099-2240, 0099-2240 KW - Oceanic Abstracts; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phages KW - Marine KW - Fecal coliforms KW - Pathogenic bacteria KW - Clostridium perfringens KW - Estuaries KW - Disease control KW - Public health KW - Bioaccumulation KW - Viral diseases KW - Escherichia coli KW - Crassostrea virginica KW - Seafood KW - Disease detection KW - Seasonal variations KW - Fishery products KW - V 22123:Epidemiology KW - A 01017:Human foods KW - Q1 08587:Diseases of Cultured Organisms KW - O 5060:Aquaculture KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17514163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Selective+accumulation+may+account+for+shellfish-associated+viral+illness&rft.au=Burkhardt%2C+W+III%3BCalci%2C+K+R&rft.aulast=Burkhardt&rft.aufirst=W&rft.date=2000-04-01&rft.volume=66&rft.issue=4&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.4.1375-1378.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Bioaccumulation; Viral diseases; Pathogenic bacteria; Disease control; Disease detection; Public health; Phages; Fecal coliforms; Estuaries; Seafood; Seasonal variations; Fishery products; Clostridium perfringens; Escherichia coli; Crassostrea virginica; Marine DO - http://dx.doi.org/10.1128/AEM.66.4.1375-1378.2000 ER - TY - JOUR T1 - Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity. AN - 70989701; 10745081 AB - We demonstrate that the differential effects Cbl and oncogenic 70Z/3 Cbl have on Ca(2+)/Ras-sensitive NF-AT reporters is partially due to their opposing ability to regulate phospholipase Cgamma1 (PLCgamma1) activation as demonstrated by analysis of the activation of an NF-AT reporter construct and PLCgamma1-mediated inositol phospholipid (PI) hydrolysis. Cbl over-expression resulted in reduced T cell receptor-induced PI hydrolysis, in the absence of any effect on PLCgamma1 tyrosine phosphorylation. In contrast, expression of 70Z/3 Cbl led to an increase in basal and OKT3-induced PLCgamma1 phosphorylation and PI hydrolysis. These data indicate that Cbl and 70Z/3 Cbl differentially regulate PLCgamma1 phosphorylation and activation. The implications of these data on the mechanism of Cbl-mediated signaling regulation are discussed. JF - FEBS letters AU - Graham, L J AU - DeBell, K E AU - Verí, M AU - Stoica, B AU - Mostowski, H AU - Bonvini, E AU - Rellahan, B AD - Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, HFM-564, Building 29B, Room 3NN10, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892-4555, USA. Y1 - 2000/03/31/ PY - 2000 DA - 2000 Mar 31 SP - 273 EP - 280 VL - 470 IS - 3 SN - 0014-5793, 0014-5793 KW - DNA-Binding Proteins KW - 0 KW - Isoenzymes KW - Muromonab-CD3 KW - NFATC Transcription Factors KW - Nuclear Proteins KW - Oncogene Protein v-cbl KW - Phosphatidylinositols KW - Proto-Oncogene Proteins KW - Receptors, Antigen, T-Cell KW - Recombinant Fusion Proteins KW - Retroviridae Proteins, Oncogenic KW - Transcription Factor AP-1 KW - Transcription Factors KW - Phosphotyrosine KW - 21820-51-9 KW - Proto-Oncogene Proteins c-cbl KW - EC 2.3.2.27 KW - Ubiquitin-Protein Ligases KW - Calcineurin KW - EC 3.1.3.16 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Phospholipase C gamma KW - EC 3.1.4.3 KW - ras Proteins KW - EC 3.6.5.2 KW - CBL protein, human KW - EC 6.3.2.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - ras Proteins -- genetics KW - Phosphatidylinositols -- metabolism KW - Calcineurin -- metabolism KW - Transcription Factor AP-1 -- antagonists & inhibitors KW - Transcription Factor AP-1 -- metabolism KW - Humans KW - Calcineurin -- genetics KW - Jurkat Cells KW - Phosphotyrosine -- metabolism KW - Gene Expression KW - Precipitin Tests KW - Phosphorylation -- drug effects KW - Recombinant Fusion Proteins -- metabolism KW - Calcium Signaling -- drug effects KW - Genes, Reporter -- genetics KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - ras Proteins -- metabolism KW - Hydrolysis -- drug effects KW - Muromonab-CD3 -- pharmacology KW - Isoenzymes -- chemistry KW - Transcription Factors -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Isoenzymes -- genetics KW - Retroviridae Proteins, Oncogenic -- metabolism KW - T-Lymphocytes -- enzymology KW - Isoenzymes -- metabolism KW - Receptors, Antigen, T-Cell -- physiology KW - Type C Phospholipases -- metabolism KW - T-Lymphocytes -- metabolism KW - Retroviridae Proteins, Oncogenic -- genetics KW - Receptors, Antigen, T-Cell -- antagonists & inhibitors KW - Type C Phospholipases -- chemistry KW - T-Lymphocytes -- drug effects KW - Proto-Oncogene Proteins -- genetics KW - Type C Phospholipases -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70989701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Differential+effects+of+Cbl+and+70Z%2F3+Cbl+on+T+cell+receptor-induced+phospholipase+Cgamma-1+activity.&rft.au=Graham%2C+L+J%3BDeBell%2C+K+E%3BVer%C3%AD%2C+M%3BStoica%2C+B%3BMostowski%2C+H%3BBonvini%2C+E%3BRellahan%2C+B&rft.aulast=Graham&rft.aufirst=L&rft.date=2000-03-31&rft.volume=470&rft.issue=3&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Degradation of Aryl Hydrocarbon Receptor (AhR) by the Ubiquitin-Proteasome Pathway. ROLE OF THE TRANSCRIPTION ACTIVATON AND DNA BINDING OF AhR AN - 17504673; 4692765 AB - Activation of the aryl hydrocarbon receptor (AhR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent agonist of AhR, induces a marked reduction in steady state AhR. To analyze the mechanism of regulation of ligand-activated AhR, we examined the biochemical pathway and function of the down- regulation of the receptor by TCDD. Pulse-chase experiments reveal that TCDD shortens the half-life (t sub(1/2)) of AhR from 28 to 3 h in mouse hepatoma cells. Inhibitors of the 26 S proteasome, lactacystin and MG132, block the TCDD-induced turnover of AhR. The TCDD- induced degradation of AhR involves ubiquitination of the AhR protein, because (a) TCDD induces formation of high molecular weight, ubiquitinated AhR and (b) degradation of AhR is inhibited in ts20 cells, which bear a temperature-sensitive mutation in the ubiquitin-activating enzyme E1, at a nonpermissive temperature. Inhibition of proteasomal degradation of AhR increases the amount of the nuclear AhR super(.)Arnt complex and "superinduces" the expression of endogenous CYP1A1 gene by TCDD, indicating that the proteasomal degradation of AhR serves as a mechanism for controlling the activity of the activated receptor. We also show that deletion of the transcription activation domain of AhR abolishes the degradation, whereas a mutation in the DNA-binding region of AhR or Arnt reduces the degradation; these data implicate the transcription activation domain and DNA binding in AhR degradation. Our findings provide new insights into the regulation of TCDD-activated AhR through ubiquitin- mediated protein degradation. JF - Journal of Biological Chemistry AU - Ma, Q AU - Baldwin, K T AD - Molecular Toxicology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, qam1@cdc.gov. Y1 - 2000/03/24/ PY - 2000 DA - 2000 Mar 24 SP - 8432 EP - 8438 VL - 275 IS - 12 SN - 0021-9258, 0021-9258 KW - mice KW - hepatoma cells KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin KW - CYP1A1 gene KW - double prime Ah receptors KW - lactacystin KW - proteosomes KW - ubiquitin KW - ubiquitin-activating enzyme E1 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Ah receptors KW - Aryl hydrocarbon nuclear translocator KW - Temperature effects KW - DNA KW - TCDD KW - Multicatalytic endopeptidase complex KW - Aryl hydrocarbon receptors KW - Transcription activation KW - Ubiquitin KW - X 24155:Biochemistry KW - N 14930:Transcription factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17504673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin-induced+Degradation+of+Aryl+Hydrocarbon+Receptor+%28AhR%29+by+the+Ubiquitin-Proteasome+Pathway.+ROLE+OF+THE+TRANSCRIPTION+ACTIVATON+AND+DNA+BINDING+OF+AhR&rft.au=Ma%2C+Q%3BBaldwin%2C+K+T&rft.aulast=Ma&rft.aufirst=Q&rft.date=2000-03-24&rft.volume=275&rft.issue=12&rft.spage=8432&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.275.12.8432 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - TCDD; Aryl hydrocarbon receptors; DNA; Transcription activation; Ubiquitin; Multicatalytic endopeptidase complex; Temperature effects; Aryl hydrocarbon nuclear translocator DO - http://dx.doi.org/10.1074/jbc.275.12.8432 ER - TY - JOUR T1 - Transforming and carcinogenic potential of cadmium chloride in BALB/c-3T3 cells. AN - 71012342; 10751619 AB - A large number of workers are potentially exposed to cadmium during mining and processing. Therefore, there is a concern regarding the potential carcinogenic hazards of cadmium to exposed workers. Studies have been performed to determine if cadmium chloride (CdCl(2)) can induce morphological cell transformation, DNA from CdCl(2)-induced transformed cells can transform other mammalian cells, and the transformed cells induced by CdCl(2) can form tumors in nude mice. BALB/c-3T3 cells were treated with different concentrations of CdCl(2) for 72 h. The frequency of transformed foci from each treatment was determined after cells were cultured for 4 to 5 weeks. DNAs from five CdCl(2)-induced transformed cell lines were isolated and gene transfection assay was performed using NIH-3T3 cells. Non-transformed BALB/c-3T3 cells and cells from 10 transformed cell lines induced by CdCl(2) were injected into both axillary regions of nude mice. Mice were screened once a week for the appearance and size of tumors. CdCl(2) caused a statistically significant, concentration-related increase in the transformation frequency. DNA from all five CdCl(2)-induced transformed cell lines tested was found to induce varying degrees of transfection-mediated transformation in NIH-3T3 cells. All 10 CdCl(2)-induced transformed cell lines formed fibrosarcomas in nude mice within 39 days of inoculation. Within this time period, no tumors were found in nude mice injected with non-transformed BALB/c-3T3 cells. These results indicate that CdCl(2) is capable of inducing morphological cell transformation and that the transformed cells induced by CdCl(2) are potentially tumorigenic. JF - Mutation research AU - Keshava, N AU - Zhou, G AU - Hubbs, A F AU - Ensell, M X AU - Ong, T m AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, m/s 3014, 1095 Willowdale Road, Morgantown, WV 26505-2845, USA. Y1 - 2000/03/14/ PY - 2000 DA - 2000 Mar 14 SP - 23 EP - 28 VL - 448 IS - 1 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - DNA, Neoplasm KW - Cadmium Chloride KW - J6K4F9V3BA KW - Index Medicus KW - Animals KW - 3T3 Cells -- drug effects KW - Transfection KW - Dose-Response Relationship, Drug KW - 3T3 Cells -- pathology KW - Carcinogenicity Tests KW - Mice, Nude KW - Mice KW - Cell Line, Transformed KW - Mice, Inbred BALB C KW - Female KW - Cadmium Chloride -- toxicity KW - Carcinogens -- toxicity KW - Cell Transformation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71012342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Transforming+and+carcinogenic+potential+of+cadmium+chloride+in+BALB%2Fc-3T3+cells.&rft.au=Keshava%2C+N%3BZhou%2C+G%3BHubbs%2C+A+F%3BEnsell%2C+M+X%3BOng%2C+T+m&rft.aulast=Keshava&rft.aufirst=N&rft.date=2000-03-14&rft.volume=448&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolism of the ethanolamine-type antihistamine diphenhydramine (Benadryl) super(TM) by the fungus Cunninghamella elegans AN - 17652015; 4721534 AB - Two strains of the filamentous fungus Cunninghamella elegans (ATCC 9245 and ATCC 36112) were grown in Sabouraud dextrose broth and screened for the ability to metabolize the ethanolamine-type antihistamine diphenhydramine. Based on the amount of parent drug recovered after 7 days incubation, both C. elegans strains metabolized approximately 74% of the diphenhydramine, 58% of this being identified as organic extractable metabolites. The organic extractable metabolites were isolated by reversed-phase high-performance liquid chromatography and identified by analyzing their mass and nuclear magnetic resonance spectra. Desorption chemical ionization mass spectrometry (DCIMS) with deuterated ammonia was used to differentiate possible isobaric diphenhydramine metabolites and to probe the mechanisms of ion formation under ammonia DCIMS conditions. C. elegans transformed diphenhydramine by demethylation, oxidation, and N-acetylation. The major metabolites observed were diphenhydramine-N-oxide (3%), N-desmethyldiphenhydramine (30%), N-acetyldidesmethyldiphenhydramine (13%), and N-acetyl-N-desmethyldiphenhydramine (12%). These compounds are known mammalian metabolites of diphenhydramine and may be useful for further toxicological studies. JF - Applied Microbiology and Biotechnology AU - Moody, J D AU - Heinze, T M AU - Hansen, EB Jr AU - Cerniglia, CE AD - Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA, CCerniglia@nctr.fda.gov Y1 - 2000/03/13/ PY - 2000 DA - 2000 Mar 13 SP - 310 EP - 315 PB - Springer-Verlag VL - 53 IS - 3 SN - 0175-7598, 0175-7598 KW - N-Acetylydidestheryldiphenhydramine KW - Cunninghamella elegans KW - N-Acetyl-N-desmethyldiphenhydramine KW - N-Desmethyldiphenhydramine KW - N-acetyl-N-desmethyldiphenhydramine KW - N-acetylydidestheryldiphenhydramine KW - diphenhydramine KW - diphenhydramine-N-oxide KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Antihistamines KW - Metabolism KW - Toxicology KW - A 01016:Microbial degradation KW - W 30965:Miscellaneous, Reviews KW - W3 33390:Products: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17652015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Metabolism+of+the+ethanolamine-type+antihistamine+diphenhydramine+%28Benadryl%29+super%28TM%29+by+the+fungus+Cunninghamella+elegans&rft.au=Moody%2C+J+D%3BHeinze%2C+T+M%3BHansen%2C+EB+Jr%3BCerniglia%2C+CE&rft.aulast=Moody&rft.aufirst=J&rft.date=2000-03-13&rft.volume=53&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cunninghamella elegans; Antihistamines; Toxicology; Metabolism ER - TY - JOUR T1 - Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo. AN - 72220780; 10965493 AB - Human breast carcinoma cell lines express high-affinity interleukin-4 receptors (IL-4R). We examined the expression and structure of these receptors on primary and cultured breast carcinoma cell lines and normal breast epithelial cells. We also tested the antitumor activity in vitro and in vivo of a fusion protein comprised of circular permuted IL-4 and truncated Pseudomonas exotoxin, termed IL-4(38-37)-PE38KDEL. Eight different primary cell cultures and cell lines of human breast carcinomas were examined for the expression of IL-4R by radiolabeled binding, reverse transcription polymerase chain reaction (RT-PCR) and Northern analyses, and subunit structure by crosslinking studies. The antitumor activity of IL-4 toxin was tested in vitro by cytotoxicity assays and in vivo in a xenograft model in immunodeficient animals. 125I-IL-4 specifically bound to primary cell cultures and cell lines with a Kd ranging between 0.2 and 1 nM. Breast tumor cells were found to express IL-4R beta and IL-13R alpha' chains, but not IL-2R gamma c chain. These cells were highly sensitive to the cytotoxic effect of IL-4(38-37)-PE38KDEL. The IC50 (concentration inhibiting protein synthesis by 50%) ranged between approximately 0.005-1.5 nM. A normal breast epithelial cell culture was not sensitive to the cytotoxic activity of IL-4(38-37)-PE38KDEL. MDA-MB231 human breast carcinoma cell line formed a rapidly growing tumor in nude mice. Intratumor and intraperitoneal administration of IL-4(38-37)-PE38KDEL caused a dose dependent regression of established tumors. A control toxin, anti-Tac(Fv)-PE38KDEL, targeted to the IL-2 receptor alpha chain did not cause regression of these tumors. These results suggest that IL-4(38-37)-PE38KDEL may be a useful agent for targeting of IL-4 receptor positive human breast carcinomas and further studies should be performed to explore fully its potential. JF - Molecular medicine (Cambridge, Mass.) AU - Leland, P AU - Taguchi, J AU - Husain, S R AU - Kreitman, R J AU - Pastan, I AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Food and Drug Administration, Bethesda, Maryland, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 165 EP - 178 VL - 6 IS - 3 SN - 1076-1551, 1076-1551 KW - Antineoplastic Agents KW - 0 KW - Bacterial Toxins KW - Cross-Linking Reagents KW - DNA Primers KW - Exotoxins KW - Immunotoxins KW - RNA, Messenger KW - RNA, Neoplasm KW - Receptors, Interleukin-4 KW - Virulence Factors KW - interleukin 4 (38-37)-PE38KDEL KW - Interleukin-4 KW - 207137-56-2 KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Animals KW - DNA Primers -- genetics KW - Humans KW - Gene Expression KW - Mice KW - Mice, Nude KW - RNA, Neoplasm -- genetics KW - RNA, Messenger -- genetics KW - Neoplasm Transplantation KW - Base Sequence KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Transplantation, Heterologous KW - Antineoplastic Agents -- pharmacology KW - Female KW - RNA, Neoplasm -- metabolism KW - Breast Neoplasms -- immunology KW - Breast Neoplasms -- drug therapy KW - Interleukin-4 -- metabolism KW - Immunotoxins -- therapeutic use KW - Exotoxins -- therapeutic use KW - Interleukin-4 -- chemistry KW - Interleukin-4 -- therapeutic use KW - Receptors, Interleukin-4 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72220780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.atitle=Human+breast+carcinoma+cells+express+type+II+IL-4+receptors+and+are+sensitive+to+antitumor+activity+of+a+chimeric+IL-4-Pseudomonas+exotoxin+fusion+protein+in+vitro+and+in+vivo.&rft.au=Leland%2C+P%3BTaguchi%2C+J%3BHusain%2C+S+R%3BKreitman%2C+R+J%3BPastan%2C+I%3BPuri%2C+R+K&rft.aulast=Leland&rft.aufirst=P&rft.date=2000-03-01&rft.volume=6&rft.issue=3&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.issn=10761551&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-06 N1 - Date created - 2000-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization and variability of endotoxin and 3-hydroxy fatty acids in an office building during a particle intervention study. AN - 71164198; 10842455 AB - Air and dust samples were collected on two floors of an office building during a double-blind particle intervention study to examine spatial and temporal variability of airborne endotoxin over a period of weeks, and to characterize endotoxin activity and lipopolysaccharide (LPS) content in carpet and chair dust. Air samples were collected on multiple days within and across weeks. Dust samples were collected from carpets and chairs one day per week for three weeks. Endotoxin was measured using a Limulus assay. Dust samples were analyzed for LPS by determination of 3-hydroxy fatty acids (3-OHFAs) using gas chromatography-mass spectrometry. The geometric mean (geometric standard deviation) for 96 indoor air samples was 0.24 (1.6) EU/m3. Significant within-floor spatial variation of airborne endotoxin was found (P < 0.0001, n = 80). Temporal variability of airborne endotoxin was not significant across weeks. Mean (+/- SD) endotoxin levels in carpet dust (59 +/- 9.3 EU/mg dust, n = 12) and in chair dust (38 +/- 7.7 EU/mg dust, n = 10) were significantly different (P < 0.001). Carbon chain length-dependent differences in 3-OHFA levels by dust source and floor were found. Enhanced air filtration did not significantly affect airborne endotoxin (P = 0.62); however, total dust mass and total endotoxin in carpet dust samples increased significantly after enhanced surface cleaning (P < 0.01). These findings suggest that spatial variability, dust source, and surface cleaning may influence building occupant exposures to endotoxin. JF - Indoor air AU - Hines, C J AU - Milton, D K AU - Larsson, L AU - Petersen, M R AU - Fisk, W J AU - Mendell, M J AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. cjh8@cdc.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 2 EP - 12 VL - 10 IS - 1 SN - 0905-6947, 0905-6947 KW - Dust KW - 0 KW - Endotoxins KW - Fatty Acids KW - Index Medicus KW - Interior Design and Furnishings KW - Ventilation KW - Particle Size KW - Humans KW - Limulus Test KW - Environmental Exposure -- prevention & control KW - Air Pollution, Indoor -- analysis KW - Endotoxins -- analysis KW - Fatty Acids -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71164198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+air&rft.atitle=Characterization+and+variability+of+endotoxin+and+3-hydroxy+fatty+acids+in+an+office+building+during+a+particle+intervention+study.&rft.au=Hines%2C+C+J%3BMilton%2C+D+K%3BLarsson%2C+L%3BPetersen%2C+M+R%3BFisk%2C+W+J%3BMendell%2C+M+J&rft.aulast=Hines&rft.aufirst=C&rft.date=2000-03-01&rft.volume=10&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Indoor+air&rft.issn=09056947&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-11 N1 - Date created - 2000-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr(VI)-induced DNA damage and Cr(IV)- or TPA-stimulated NF-kappaB activation. AN - 71147922; 10839202 AB - Electron spin resonance (ESR) spin trapping was utilized to investigate the scavenging effects on hydroxyl radicals (*OH) and superoxide radicals (O2*-) by (-)-epigallocatechin-3-gallate (EGCG), one of the major anticancer compounds in tea. The spin trap used was 5,5-dimethyl-pyrroline N-oxide (DMPO). The Fenton reaction (Fe2+ + H2O2-->Fe3+ + *OH + OH-) was used as a source of *OH radicals. EGCG efficiently scavenges *OH radicals with reaction rate of 4.62 x 10(11) M(-1)sec(-1), which is an order of magnitude higher than several well recognized antioxidants, such as ascorbate, glutathione and cysteine. It also scavenges O2*- radicals as demonstrated by using xanthine and xanthine oxidase system as a source of O2*- radicals. Through its antioxidant properties, EGCG exhibited a protective effect against DNA damage induced by Cr(VI). EGCG also inhibited activation of nuclear transcription factor NF-kappaB induced by Cr(IV) and 12-o-tetradecanoylphorbol-13-acetate (TPA). The present studies provide a mechanistic basis for the reported anticarcinogenic properties of EGCG and related tea products. JF - Molecular and cellular biochemistry AU - Shi, X AU - Ye, J AU - Leonard, S S AU - Ding, M AU - Vallyathan, V AU - Castranova, V AU - Rojanasakul, Y AU - Dong, Z AD - Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 125 EP - 132 VL - 206 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Antioxidants KW - 0 KW - Chromates KW - Free Radical Scavengers KW - NF-kappa B KW - Chromium KW - 0R0008Q3JB KW - Superoxides KW - 11062-77-4 KW - chromium hexavalent ion KW - 18540-29-9 KW - Hydroxyl Radical KW - 3352-57-6 KW - Catechin KW - 8R1V1STN48 KW - epicatechin gallate KW - 92587OVD8Z KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Superoxides -- metabolism KW - Jurkat Cells -- metabolism KW - Hydroxyl Radical -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - Cells, Cultured KW - Humans KW - Electron Spin Resonance Spectroscopy KW - Chromates -- antagonists & inhibitors KW - Antioxidants -- pharmacology KW - Chromium -- antagonists & inhibitors KW - Catechin -- analogs & derivatives KW - Chromium -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Tetradecanoylphorbol Acetate -- antagonists & inhibitors KW - Catechin -- pharmacology KW - NF-kappa B -- metabolism KW - DNA Damage -- drug effects KW - Chromates -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71147922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Antioxidant+properties+of+%28-%29-epicatechin-3-gallate+and+its+inhibition+of+Cr%28VI%29-induced+DNA+damage+and+Cr%28IV%29-+or+TPA-stimulated+NF-kappaB+activation.&rft.au=Shi%2C+X%3BYe%2C+J%3BLeonard%2C+S+S%3BDing%2C+M%3BVallyathan%2C+V%3BCastranova%2C+V%3BRojanasakul%2C+Y%3BDong%2C+Z&rft.aulast=Shi&rft.aufirst=X&rft.date=2000-03-01&rft.volume=206&rft.issue=1-2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-21 N1 - Date created - 2000-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proficiency Analytical Testing (PAT) Program November 1999. AN - 71069999; 10782203 JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Feng, H A AU - Schlecht, P AD - HHS/PHS/CDC/NIOSH, Cincinnati, OH 45226, USA. PY - 2000 SP - 295 EP - 296 VL - 61 IS - 2 SN - 1529-8663, 1529-8663 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - United States KW - Reference Standards KW - National Institute for Occupational Safety and Health (U.S.) KW - Environmental Pollutants -- standards KW - Environmental Pollutants -- analysis KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71069999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Proficiency+Analytical+Testing+%28PAT%29+Program+November+1999.&rft.au=Feng%2C+H+A%3BSchlecht%2C+P&rft.aulast=Feng&rft.aufirst=H&rft.date=2000-03-01&rft.volume=61&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-16 N1 - Date created - 2000-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental Lead Proficiency Analytical Testing (ELPAT) Program September 1999. AN - 71067959; 10782204 JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Feng, H A AU - Schlecht, P AD - HHS/PHS/CDC/NIOSH, Cincinnati, OH 45226, USA. PY - 2000 SP - 297 EP - 300 VL - 61 IS - 2 SN - 1529-8663, 1529-8663 KW - Dust KW - 0 KW - Environmental Pollutants KW - Soil Pollutants KW - Lead KW - 2P299V784P KW - Index Medicus KW - United States KW - Dust -- analysis KW - Soil Pollutants -- standards KW - Reference Standards KW - National Institute for Occupational Safety and Health (U.S.) KW - Soil Pollutants -- analysis KW - Lead -- standards KW - Environmental Monitoring -- standards KW - Environmental Pollutants -- analysis KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71067959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Environmental+Lead+Proficiency+Analytical+Testing+%28ELPAT%29+Program+September+1999.&rft.au=Feng%2C+H+A%3BSchlecht%2C+P&rft.aulast=Feng&rft.aufirst=H&rft.date=2000-03-01&rft.volume=61&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-16 N1 - Date created - 2000-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mist control at a machining center, Part 1: Mist characterization. AN - 71067031; 10782200 AB - At a machining center used to produce transmission parts, aerosol instrumentation was used to quantitatively study mist generation and to evaluate the performance of an air cleaner for controlling the mist. This machining center drilled and tapped holes at rotational speeds of 1000 to 3000 rpm. During most machining operations, the metal-working fluid (MWF) was flooded over the part. To facilitate metal chip removal during some operations, MWF was pumped through the orifices in some tools at a pressure of 800 psi. These machining operations were performed in a nearly complete enclosure that was exhausted to an air cleaner at a flow rate of 1.1 m3/sec (2400 ft3/m). Although the use of high-pressure MWF increased the mist concentration by about 200%, it did not affect the mist size distribution. The observed penetration through the air cleaner appeared to be mostly consistent with the manufacturer's specifications on the air cleaner's filters. During the testing, MWF was observed to accumulate in the bottom of the filter housing and may have been reentrained due to air motion or mechanical vibration. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Heitbrink, W A AU - Yacher, J M AU - Deye, G J AU - Spencer, A B AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH 45226-1998, USA. PY - 2000 SP - 275 EP - 281 VL - 61 IS - 2 SN - 1529-8663, 1529-8663 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Index Medicus KW - Occupational Exposure KW - Particle Size KW - Filtration -- instrumentation KW - Automobiles KW - Industry KW - Aerosols -- analysis KW - Air Pollutants, Occupational -- analysis KW - Air Pollution, Indoor -- prevention & control KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71067031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Mist+control+at+a+machining+center%2C+Part+1%3A+Mist+characterization.&rft.au=Heitbrink%2C+W+A%3BYacher%2C+J+M%3BDeye%2C+G+J%3BSpencer%2C+A+B&rft.aulast=Heitbrink&rft.aufirst=W&rft.date=2000-03-01&rft.volume=61&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-16 N1 - Date created - 2000-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mist control at a machining center, Part 2: Mist control following installation of air cleaners. AN - 71055784; 10782201 AB - At a machining center used to produce transaxle and transmission parts, aerosol instrumentation was used to quantitatively evaluate size-dependent mist generation of a synthetic metalworking fluid (MWF) consisting primarily of water and triethanolamine (TEA). This information was used to select an air cleaner for controlling the mist. During most machining operations, the MWF was flooded over the part. These machining operations were performed in a nearly complete enclosure that was exhausted to an air cleaner consisting of three sections: a fall-out chamber, a trifilter section to capture metal chips and mist, and a 1.13 m3/sec (2400 ft3/min) blower. The partnering company requested that National Institute for Occupational Safety and Health (NIOSH) researchers perform an evaluation of the effectiveness of a commercially available air cleaner. After NIOSH researchers characterized mist generation at the machining centers and found that performance of a test air cleaner appeared to be suitable, the company installed more than 25 air cleaners on different machining centers in this plant and enclosed the corresponding fluid filtration unit. The facility also has implemented a maintenance program for the air cleaners that involves regularly scheduled filter changes; performance is ensured by monitoring static pressure. A NIOSH-conducted air sampling evaluation showed that area TEA concentrations were reduced from a geometric mean of 0.25 to 0.03 mg/m3. Personal total particulate concentrations were reduced from a geometric mean of 0.22 to 0.06 mg/m3. These results show the effectiveness of this combination of enclosure, ventilation, and filtration to greatly reduce the exposure to MWF mist generated in modern machining centers. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Yacher, J M AU - Heitbrink, W A AU - Burroughs, G E AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. PY - 2000 SP - 282 EP - 289 VL - 61 IS - 2 SN - 1529-8663, 1529-8663 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Ethanolamines KW - Water KW - 059QF0KO0R KW - triethanolamine KW - 9O3K93S3TK KW - Index Medicus KW - Aerosols -- analysis KW - Particle Size KW - Filtration -- instrumentation KW - Automobiles KW - Water -- analysis KW - Air Pollutants, Occupational -- analysis KW - Air Pollution, Indoor -- prevention & control KW - Metallurgy KW - Ethanolamines -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71055784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Mist+control+at+a+machining+center%2C+Part+2%3A+Mist+control+following+installation+of+air+cleaners.&rft.au=Yacher%2C+J+M%3BHeitbrink%2C+W+A%3BBurroughs%2C+G+E&rft.aulast=Yacher&rft.aufirst=J&rft.date=2000-03-01&rft.volume=61&rft.issue=2&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-16 N1 - Date created - 2000-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of (known) control values to (unknown) test values in proficiency studies of pesticide residues. AN - 71043360; 10772178 AB - Proficiency studies have been suggested as an alternative source of information for evaluating method performance characteristics when results from interlaboratory method performance studies conforming to internationally recognized protocols are not available. To explore this possibility, results were examined from ongoing proficiency studies of pesticide residue analyses in celery, carrot, and grape purees, and in wine. Statistical performance parameters were calculated from 18 data sets analyzed as unknowns by about 60 analysts for 12 analytes in the 25-1,000 microg/kg range, and from presumably parallel control (spike) analyses conducted by about half of the participants. A surprising finding was that recovery of known, independent control additions by the participant did not correlate with the recoveries determined as unknowns in the exercise. The data suggest that censoring or truncating of control data has occurred. The question of substitution of proficiency data for method performance data cannot be answered until the problem of unbiased reporting of control data is resolved. JF - Journal of AOAC International AU - Horwitz, W AU - Wood, R AD - U.S. Food and Drug Administration, HFS-500, Washington, DC 20204, USA. PY - 2000 SP - 399 EP - 406 VL - 83 IS - 2 SN - 1060-3271, 1060-3271 KW - Pesticide Residues KW - 0 KW - Thiabendazole KW - N1Q45E87DT KW - Index Medicus KW - Chromatography, Gas KW - Apiaceae -- chemistry KW - Wine -- analysis KW - Food Contamination KW - Daucus carota -- chemistry KW - Fruit -- chemistry KW - Chromatography, High Pressure Liquid KW - Thiabendazole -- analysis KW - Food Analysis -- statistics & numerical data KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Pesticide Residues -- analysis KW - Quality Control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71043360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Relationship+of+%28known%29+control+values+to+%28unknown%29+test+values+in+proficiency+studies+of+pesticide+residues.&rft.au=Horwitz%2C+W%3BWood%2C+R&rft.aulast=Horwitz&rft.aufirst=W&rft.date=2000-03-01&rft.volume=83&rft.issue=2&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-31 N1 - Date created - 2000-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibiotic use in food animals: controlling the human health impact. AN - 71037370; 10772160 AB - Resistance to antimicrobial drugs has compromised control of many bacterial pathogens. For foodborne pathogens, the most likely source of resistance is use of antimicrobials in food-producing animals. To control the human health impact from use of antimicrobials in animals, the U.S. Food and Drug Administration (FDA) recently announced plans to assess the microbial safety of all antimicrobials intended for use in food-producing animals. This paper describes the history of antimicrobial use and regulation in animals, the public health concern, the current animal drug approval process in the United States, the international perspective, and FDA's proposed procedures to evaluate the human health impact of the antimicrobial effects associated with animal drugs intended for use in food-producing animals. The primary public health goal of the improved regulatory paradigm is to ensure that significant human antimicrobial therapies are not lost due to use of antimicrobials in food animals. JF - Journal of AOAC International AU - Tollefson, L AU - Miller, M A AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Rockville, MD 20855, USA. PY - 2000 SP - 245 EP - 254 VL - 83 IS - 2 SN - 1060-3271, 1060-3271 KW - Anti-Bacterial Agents KW - 0 KW - Veterinary Drugs KW - Index Medicus KW - History of medicine KW - United States KW - Animals KW - United States Food and Drug Administration KW - History, 20th Century KW - Humans KW - Legislation, Drug KW - Animals, Domestic KW - Public Health KW - Food Contamination KW - Drug Resistance, Microbial KW - Anti-Bacterial Agents -- administration & dosage KW - Veterinary Drugs -- history KW - Anti-Bacterial Agents -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71037370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Antibiotic+use+in+food+animals%3A+controlling+the+human+health+impact.&rft.au=Tollefson%2C+L%3BMiller%2C+M+A&rft.aulast=Tollefson&rft.aufirst=L&rft.date=2000-03-01&rft.volume=83&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-31 N1 - Date created - 2000-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A new video-synchronized multichannel biomedical data acquisition system. AN - 71012283; 10743785 AB - This data acquisition system records video frames onto a video tape, and simultaneously acquires biomedical data along with video time codes onto a computer hard disk to achieve a 30-min video-synchronized data recording with a summed data rate of 2.16 Mbit/s. A time-code-bridge-file created during acquisition matches each video frame-start with the corresponding index number of the acquired data. The mean synchronization accuracy of the system is 0.22 ms. JF - IEEE transactions on bio-medical engineering AU - Zeng, S AU - Powers, J R AU - Hsiao, H AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. saz0@cdc.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 412 EP - 419 VL - 47 IS - 3 SN - 0018-9294, 0018-9294 KW - Index Medicus KW - Environmental Monitoring KW - Medical Records Systems, Computerized KW - Signal Processing, Computer-Assisted KW - Humans KW - Computers KW - Computer Graphics KW - Monitoring, Physiologic KW - Software Design KW - Video Recording KW - Data Collection -- methods KW - Information Storage and Retrieval -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71012283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+transactions+on+bio-medical+engineering&rft.atitle=A+new+video-synchronized+multichannel+biomedical+data+acquisition+system.&rft.au=Zeng%2C+S%3BPowers%2C+J+R%3BHsiao%2C+H&rft.aulast=Zeng&rft.aufirst=S&rft.date=2000-03-01&rft.volume=47&rft.issue=3&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=IEEE+transactions+on+bio-medical+engineering&rft.issn=00189294&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-19 N1 - Date created - 2000-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of surface ultraviolet B radiation levels with melanoma and nonmelanoma skin cancer in United States blacks. AN - 71009409; 10750668 AB - Ultraviolet B (UVB) radiation exposure increases the risk of skin cancer in whites. Motivated by indications that United States geographic variation of relative skin cancer risk in blacks approaches that in whites, we used Poisson regression to estimate the risk of skin cancer in blacks as a function of average annual surface-levels of UVB radiation, measured by Robertson-Berger meters. United States data were used on deaths in 506 state economic areas, 1970-1994, and on incident cases in the nine areas of the Surveillance, Epidemiology, and End Results Program, 1973-1994. For black males, the age-adjusted relative risk of mortality for a 50% increase in UVB radiation was significantly above one for malignant melanoma, 1970-1994 (1.16; 95% confidence interval, 1.02-1.32) and nearly so for nonmelanoma skin cancer, 1970-1981 (1.18; 95% confidence interval, 1.00-1.39), for which the time period was chosen to avoid AIDS-related deaths from Kaposi's sarcoma. However, for black females, the relative risk of mortality was not significantly elevated for either skin cancer, and, for both black males and females, the relative risk of incidence was not significantly elevated for melanoma in the period 1973-1994. Incidence data on nonmelanoma skin cancer were not available. Although the public health implication is uncertain because of the much lower absolute risk of skin cancer in blacks compared with whites, the findings suggest that sunlight exposure increases skin cancer risk in blacks. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Pennello, G AU - Devesa, S AU - Gail, M AD - United States Food and Drug Administration, Center for Radiological Devices and Health, Rockville, Maryland 20850, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 291 EP - 297 VL - 9 IS - 3 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Humans KW - SEER Program KW - Infant, Newborn KW - Aged KW - Child KW - Risk Assessment KW - Child, Preschool KW - Infant KW - Public Health KW - Aged, 80 and over KW - Adult KW - Environmental Exposure KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Skin Neoplasms -- ethnology KW - Skin Neoplasms -- etiology KW - Melanoma -- etiology KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- epidemiology KW - Melanoma -- ethnology KW - African Continental Ancestry Group KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71009409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Association+of+surface+ultraviolet+B+radiation+levels+with+melanoma+and+nonmelanoma+skin+cancer+in+United+States+blacks.&rft.au=Pennello%2C+G%3BDevesa%2C+S%3BGail%2C+M&rft.aulast=Pennello&rft.aufirst=G&rft.date=2000-03-01&rft.volume=9&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-12 N1 - Date created - 2000-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative image analysis of lung connective tissue in murine silicosis. AN - 71005797; 10742923 AB - Pulmonary fibrosis is a disabling consequence of many lung diseases but is difficult to quantify. Lucifer yellow CH fluorescent dye (LY) appears to stain connective tissue matrix macromolecules selectively. Laser scanning confocal microscopy can quantify the intensity of fluorescence and determine the area of fluorescent material. We hypothesized that the abundance of lucifer yellow-stained matrix macromolecules in lung tissue sections could be measured by laser scanning confocal microscopy, would reflect differences between varying degrees of pulmonary fibrosis, and could be compared directly to biochemical measurements of lung collagen. We exposed C57B1/6 and 129 strains of mice by aerosol to cristobalite silica (70 mg/m3, 12 days, 5 hours/day) or sham-air and examined them 2 and 16 weeks after exposure. The area of LY-stained matrix in tissue sections was quantitated by laser scanning confocal microscopy, and total lung collagen was measured biochemically as hydroxyproline (OH-proline). The LY-stained connective tissue matrix appeared as bright linear bands in the alveolar septae, and was increased significantly by image analysis in C57B1/6 and 129 mice with silicosis 16 weeks after exposure. Total lung OH-proline was significantly increased in silica-exposed mice from both stains at both time points. Comparing all 8 groups, there was a significant linear correlation between the average area of connective tissue measured by LY stain and the total OH-proline per lung measured by chemical analysis (r = .72, P = .042). LY staining and confocal microscopy with image analysis offers a rapid technique for quantitative measurements of the extent of pulmonary fibrosis. JF - Experimental lung research AU - Antonini, J M AU - Hemenway, D R AU - Davis, G S AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 71 EP - 88 VL - 26 IS - 2 SN - 0190-2148, 0190-2148 KW - Fluorescent Dyes KW - 0 KW - Isoquinolines KW - Collagen KW - 9007-34-5 KW - lucifer yellow KW - 9654F8OVKE KW - Hydroxyproline KW - RMB44WO89X KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Collagen -- metabolism KW - Connective Tissue -- metabolism KW - Connective Tissue -- pathology KW - Mice KW - Pulmonary Fibrosis -- metabolism KW - Pulmonary Fibrosis -- pathology KW - Mice, Inbred C57BL KW - Image Processing, Computer-Assisted KW - Hydroxyproline -- metabolism KW - Silicosis -- metabolism KW - Silicosis -- pathology KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71005797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Quantitative+image+analysis+of+lung+connective+tissue+in+murine+silicosis.&rft.au=Antonini%2C+J+M%3BHemenway%2C+D+R%3BDavis%2C+G+S&rft.aulast=Antonini&rft.aufirst=J&rft.date=2000-03-01&rft.volume=26&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-19 N1 - Date created - 2000-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. AN - 71001362; 10746941 AB - We have utilized a validated (standardized) estrogen receptor (ER) competitive-binding assay to determine the ER affinity for a large, structurally diverse group of chemicals. Uteri from ovariectomized Sprague-Dawley rats were the ER source for the competitive-binding assay. Initially, test chemicals were screened at high concentrations to determine whether a chemical competed with [3H]-estradiol for the ER. Test chemicals that exhibited affinity for the ER in the first tier were subsequently assayed using a wide range of concentrations to characterize the binding curve and to determine each chemical's IC50 and relative binding affinity (RBA) values. Overall, we assayed 188 chemicals, covering a 1 x 10(6)-fold range of RBAs from several different chemical or use categories, including steroidal estrogens, synthetic estrogens, antiestrogens, other miscellaneous steroids, alkylphenols, diphenyl derivatives, organochlorines, pesticides, alkylhydroxybenzoate preservatives (parabens), phthalates, benzophenone compounds, and a number of other miscellaneous chemicals. Of the 188 chemicals tested, 100 bound to the ER while 88 were non-binders. Included in the 100 chemicals that bound to the ER were 4-benzyloxyphenol, 2,4-dihydroxybenzophenone, and 2,2'-methylenebis(4-chlorophenol), compounds that have not been shown previously to bind the ER. It was also evident that certain structural features, such as an overall ring structure, were important for ER binding. The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Blair, R M AU - Fang, H AU - Branham, W S AU - Hass, B S AU - Dial, S L AU - Moland, C L AU - Tong, W AU - Shi, L AU - Perkins, R AU - Sheehan, D M AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. rblair@nctr.fda.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 138 EP - 153 VL - 54 IS - 1 SN - 1096-6080, 1096-6080 KW - Benzophenones KW - 0 KW - Biphenyl Compounds KW - Insecticides KW - Ligands KW - Phenols KW - Phthalic Acids KW - Receptors, Estrogen KW - Steroids KW - Xenobiotics KW - Index Medicus KW - Insecticides -- metabolism KW - Animals KW - Benzophenones -- metabolism KW - Phenols -- pharmacology KW - Phenols -- metabolism KW - Phthalic Acids -- metabolism KW - Binding, Competitive -- drug effects KW - Biphenyl Compounds -- pharmacology KW - Uterus -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Phthalic Acids -- pharmacology KW - Benzophenones -- pharmacology KW - Biphenyl Compounds -- metabolism KW - Insecticides -- pharmacology KW - Female KW - Steroids -- metabolism KW - Xenobiotics -- metabolism KW - Receptors, Estrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71001362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+estrogen+receptor+relative+binding+affinities+of+188+natural+and+xenochemicals%3A+structural+diversity+of+ligands.&rft.au=Blair%2C+R+M%3BFang%2C+H%3BBranham%2C+W+S%3BHass%2C+B+S%3BDial%2C+S+L%3BMoland%2C+C+L%3BTong%2C+W%3BShi%2C+L%3BPerkins%2C+R%3BSheehan%2C+D+M&rft.aulast=Blair&rft.aufirst=R&rft.date=2000-03-01&rft.volume=54&rft.issue=1&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-02 N1 - Date created - 2000-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ozone. The good, the bad, and the ugly. AN - 70996936; 10737029 AB - Sensitive individuals are at risk of adverse health effects from exposure to even modest levels of ozone. Such individuals are likely to develop respiratory symptoms and are more likely to be hospitalized when exposed to ozone at currently accepted levels. A review of scientific documents regarding the health effects of ozone has led the DHHS to agree with the EPA that the primary ambient air standard for ozone should be changed from 0.12 ppm (1-hour average) to 0.08 ppm (8-hour average). Achieving the proposed 0.08 ppm standard should decrease physician visits, hospitalization, and use of respiratory medications. In addition, because very susceptible healthy individuals may experience adverse health effects of the current standard, it is clear that the current standard provides little or no margin of safety, particularly for sensitive individuals. In order to avoid exposure to unhealthy levels of ozone, people should take precautions to minimize exposure from 2:00 to 6:00 pm on days when ozone levels are high. This is especially so for children, adults who are active outdoors, those with respiratory disease such as asthma, and people with unusual susceptibility to ozone. JF - North Carolina medical journal AU - Williams, L K AU - Langley, R AU - Howell, R J AD - Occupational and Environmental Epidemiology Branch, NC Department of Health and Human Services. PY - 2000 SP - 84 EP - 89 VL - 61 IS - 2 SN - 0029-2559, 0029-2559 KW - Air Pollutants KW - 0 KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Environmental Monitoring KW - Air Pollution, Indoor KW - Humans KW - North Carolina KW - Adult KW - Child KW - Respiration Disorders -- prevention & control KW - Respiration Disorders -- etiology KW - Environmental Exposure -- prevention & control KW - Environmental Exposure -- adverse effects KW - Air Pollutants -- adverse effects KW - Ozone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70996936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=North+Carolina+medical+journal&rft.atitle=Ozone.+The+good%2C+the+bad%2C+and+the+ugly.&rft.au=Williams%2C+L+K%3BLangley%2C+R%3BHowell%2C+R+J&rft.aulast=Williams&rft.aufirst=L&rft.date=2000-03-01&rft.volume=61&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=North+Carolina+medical+journal&rft.issn=00292559&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-13 N1 - Date created - 2000-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas. AN - 70959549; 10728667 AB - Human malignant glioma cell lines express high levels of interleukin-13 receptor (IL-13R). However, the subunit structure of this receptor in primary brain tumor cells is not known. Herein, we examined the subunit composition of IL-13R by analyzing the expression of four different putative subunits of IL-13R complex in 25 primary explants of malignant brain tumors. Reverse transcription-PCR (RT-PCR) of RNA from these tumor cells, normal astrocytes, and normal brain tissue showed that transcripts of IL-13R alpha chain were present in greater abundance in malignant glioma cells compared with normal astrocytes or normal brain tissues. The transcripts for two other chains (e.g., IL-13Ralpha' and IL-4Rbeta), on the other hand, yielded similar PCR positivity in brain tumors as well as in normal samples, whereas transcripts for gammac chain were absent in all brain tumor cells and normal tissues. The specificity of RT-PCR products for these genes was confirmed by oligo liquid hybridization analysis using a radiolabeled sequence-specific internal probe. Indirect immunofluorescence studies for different receptor chains confirmed the RT-PCR results and demonstrated a striking difference in the level of expression of IL-13Ralpha protein between normal astrocytes and malignant astrocytoma cells. These studies establish the IL-13Ralpha subunit as a novel tumor-specific protein that may be useful as a tumor marker, a target for cytotoxin/immunotoxin, or alternatively, a tumor-associated antigen for active, specific immunotherapy. JF - Cancer research AU - Joshi, B H AU - Plautz, G E AU - Puri, R K AD - Division of Cellular and Gene Therapies, Center for Biologics, Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2000/03/01/ PY - 2000 DA - 2000 Mar 01 SP - 1168 EP - 1172 VL - 60 IS - 5 SN - 0008-5472, 0008-5472 KW - Biomarkers, Tumor KW - 0 KW - IL13RA1 protein, human KW - Interleukin-13 Receptor alpha1 Subunit KW - Receptors, Interleukin KW - Receptors, Interleukin-13 KW - Index Medicus KW - Tumor Cells, Cultured KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Reverse Transcriptase Polymerase Chain Reaction KW - Brain Neoplasms -- pathology KW - Glioma -- pathology KW - Receptors, Interleukin -- metabolism KW - Receptors, Interleukin -- genetics KW - Brain Neoplasms -- metabolism KW - Glioma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70959549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Interleukin-13+receptor+alpha+chain%3A+a+novel+tumor-associated+transmembrane+protein+in+primary+explants+of+human+malignant+gliomas.&rft.au=Joshi%2C+B+H%3BPlautz%2C+G+E%3BPuri%2C+R+K&rft.aulast=Joshi&rft.aufirst=B&rft.date=2000-03-01&rft.volume=60&rft.issue=5&rft.spage=1168&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-11 N1 - Date created - 2000-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cancer Res. 2001 Jul 15;61(14):5660-2 [11454721] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of thermophilic Campylobacter spp. in blood-free enriched samples of inoculated foods by the polymerase chain reaction. AN - 70958927; 10716555 AB - The detection of thermophilic Campylobacter spp., as represented by Campylobacter jejuni, by the polymerase chain reaction (PCR) was investigated and compared with the selective agar isolation (SAI) method. Stationary-phase cultures of C. jejuni were inoculated into either blood-free enrichment broth (BFEB) or BFEB that contained 10% broccoli, crabmeat, mushroom, raw milk, and raw oyster rinses. Following a 48-h enrichment period, aliquots of food test portions were removed for simultaneous analysis by PCR and SAI. It was determined that the presence of charcoal and iron in the enrichment broth interfered with the PCR assay. Therefore, three DNA extraction techniques were developed and evaluated using a 16S rRNA primer pair in the PCR assay. The 50% end point (DL50) values (determined upon six initial C. jejuni spiking levels) were used to assess the frequency of isolation utilizing PCR versus SAI for the detection of this organism in the enrichment matrices. There were virtually no differences in detection of C. jejuni among enriched samples analyzed by PCR and SAI. Mean DL50 values (n = 3) for plain BFEB, broccoli, crabmeat, mushroom, raw milk, and raw oyster were, respectively, 0.02 (PCR) versus 0.01 (SAI), 0.01 versus 0.06, 0.07 versus 0.04, 0.03 versus 0.08, 0.01 versus 0.01, and 0.01 versus 0.01 CFU/5 g food. Significant variability in the detection limit of C. jejuni by PCR in the food enrichments was observed among DNA extraction techniques. Using 48-h enrichment cultures followed by PCR analysis could save 1 day of the time required for the presumptive identification of C. jejuni in suspected foods. JF - Journal of food protection AU - Thunberg, R L AU - Tran, T T AU - Walderhaug, M O AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA. RTHUNBER@BANGATE.FDA.GOV Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 299 EP - 303 VL - 63 IS - 3 SN - 0362-028X, 0362-028X KW - Culture Media KW - 0 KW - RNA, Ribosomal, 16S KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - RNA, Ribosomal, 16S -- genetics KW - Genes, rRNA KW - Campylobacter jejuni -- genetics KW - Food Microbiology KW - Campylobacter jejuni -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Campylobacter jejuni -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70958927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Detection+of+thermophilic+Campylobacter+spp.+in+blood-free+enriched+samples+of+inoculated+foods+by+the+polymerase+chain+reaction.&rft.au=Thunberg%2C+R+L%3BTran%2C+T+T%3BWalderhaug%2C+M+O&rft.aulast=Thunberg&rft.aufirst=R&rft.date=2000-03-01&rft.volume=63&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-27 N1 - Date created - 2000-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mitogen-induced modulation of CD3, CD4, and CD8(1). AN - 70952264; 10689110 AB - It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogens (phytohemagglutinin [PHA], concanavalin A [ConA], and anti-CD3 monoclonal antibody [alphaCD3]) and then using multiparameter flow cytometric techniques to investigate modulation of surface (sur) and cytoplasmic (c) CD3, CD4, and CD8. Cultures with alphaCD3 had a rapid, large, and persistent decline in surCD3; the cCD3 median fluorescent intensity (MFI) declined gradually, over the entire culture period. With alphaCD3, surCD4 MFI and cCD4 MFI declined by days 4 to 8 (31% of ex vivo value, p < 0.001 and 47%, p = 0.033), as did surCD8 MFI (58%, p = 0.010). PHA was associated with an increase in surCD8%, surCD8 MFI, and cCD8% at days 4 to 8 (178% of ex vivo, p = 0.003; 168%, p = 0.025; and 331%, p = 0.001). For PHA at days 4 to 8, cCD8 MFI was highly variable but always higher than in unstimulated cultures (5 of 5 experiments). With ConA, at 3 to 5 hours ex vivo, there was a decrease in surCD3 MFI relative to ex vivo (64%), surCD4% (83%), cCD4% (87%), surCD4 MFI (50%) and cCD4 MFI (48%), surCD8% (85%) and an increase in cCD8% (260%). As with PHA, at days 4 to 8, surCD8% was high relative to ex vivo (169%). Thus, we found that alphaCD3 had delayed effects on CD4 and CD8; PHA had delayed effects on CD8 only; and ConA had very rapid effects on CD3, CD4, and CD8, as well as a delayed effect on surface CD8. These effects involve both surface and cytoplasmic antigen expression and are more consistent with degradation or retention, rather than with shedding or increased production. They may reflect direct interactions between CD4 or CD8 and CD3 and/or interregulation of CD3 expression with expression of these coreceptor molecules. JF - Human immunology AU - Jason, J AU - Inge, K L AD - Immunology Branch, Division of AIDS, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA. JMJ1@cdc.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 202 EP - 211 VL - 61 IS - 3 SN - 0198-8859, 0198-8859 KW - Antigens, CD3 KW - 0 KW - Antigens, CD4 KW - Antigens, CD8 KW - Mitogens KW - Phytohemagglutinins KW - Concanavalin A KW - 11028-71-0 KW - Brefeldin A KW - 20350-15-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Mitogens -- pharmacology KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Brefeldin A -- pharmacology KW - Phytohemagglutinins -- pharmacology KW - Concanavalin A -- pharmacology KW - Antigens, CD3 -- biosynthesis KW - Antigens, CD4 -- biosynthesis KW - Antigens, CD8 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70952264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+immunology&rft.atitle=Mitogen-induced+modulation+of+CD3%2C+CD4%2C+and+CD8%281%29.&rft.au=Jason%2C+J%3BInge%2C+K+L&rft.aulast=Jason&rft.aufirst=J&rft.date=2000-03-01&rft.volume=61&rft.issue=3&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Human+immunology&rft.issn=01988859&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-27 N1 - Date created - 2000-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - National Household Survey on Drug Abuse Main Findings 1998. AN - 62429803; ED442033 AB - This survey, monitoring levels of substance abuse in the United States, serves as a tool for researchers and policymakers to better understand and control substance abuse problems. It provides information on 25,500 participants' use of illicit drugs, alcohol, and tobacco among the civilian, noninstutionalized population. Trends for the years, 1979, 1985, and 1991 through 1998 are included. For each drug (marijuana, cocaine, inhalants, hallucinogens, heroin, non-medical use of psychotherapeutics, alcohol, cigarettes, and smokeless tobacco), there are tables arranged to facilitate group comparisons. Data for the total population is presented for each of four age groups, and then compared by sex, race/ethnicity, population density, region, adult education, and current employment. Data on drug use among special populations (drug use and criminal behaviors, drug use and pregnancy, drug use among adolescents exposed to drug education messages) is also included. Seven appendixes detail procedures: Appendix A contains definitions of key terms; Appendixes B, C, and D include information on the quality of data and testing procedures; Appendix E explains the adjustment procedure that was applied to the 1979-1993 NHSDA estimated in order to facilitate long-term trend analysis; Appendix F contains answer sheets for 1998 NHSDA questionnaire; Appendix G contains pages from the questionnaire. (Contains 124 references.) (Author/JDM) Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 438 PB - Nat'l Clearinghouse for Alcohol and Drug Information, P.O. Box 2345, Rockville, MD 20847-2345; KW - ERIC, Resources in Education (RIE) KW - Demography KW - Smoking KW - Alcohol Abuse KW - Heroin KW - Incidence KW - Correlation KW - Marijuana KW - Cocaine KW - Trend Analysis KW - Family (Sociological Unit) KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62429803?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Indicators of Welfare Dependence: Annual Report to Congress. AN - 62420861; ED441908 AB - This report addresses questions concerning the extent to which U.S. families depend on income from welfare programs, offering updated data on measures of welfare recipiency, dependency, and predictors of welfare dependence developed for previous reports. Chapter 1, "Introduction," reviews specific summary measures of welfare dependence proposed by the Advisory Board on Welfare Indicators, discussing summary measures of poverty. Chapter 2, "Indicators of Dependence," presents a broader group of indicators of welfare recipiency and dependence, including measures of the extent of recipiency for each of three programs considered separately and information on income from all three programs together. It shows interactions of Aid to Families with Dependent Children/Temporary Assistance for Needy Families, Supplemental Security Income, and food stamp benefits with periods of employment and with benefits from other programs. It also includes data on movements on and off welfare. Chapter 3, "Predictors of Risk and Risk Factors Associated with Welfare Receipt," examines predictors of welfare dependence possibly associated with welfare receipt. Predictors are shown in three groups: economic security, work status, and non-marital births. Two appendixes present program data on each of the main welfare programs and their recipients and additional non-marital birth data. (SM) Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 161 PB - Office of Human Services Policy, Assistant Secretary for Planning and Evaluation, Hubert H. Humphrey Building, Room 410E, 200 Independence Avenue, S.W., Washington, DC 20201. Fax: 202-690-6562. For full text: http://www.aspe.hhs.gov/hsp/hsp-home.htm. KW - Aid to Families with Dependent Children KW - Dependency (Economics) KW - Supplemental Security Income Program KW - Temporary Assistance for Needy Families KW - ERIC, Resources in Education (RIE) KW - Low Income Groups KW - Welfare Recipients KW - Economically Disadvantaged KW - Welfare Services KW - Tables (Data) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62420861?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - "Contributors to this report include Gil Crouse, S N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Patterns of Alcohol Use among Adolescents and Associations with Emotional and Behavioral Problems. OAS Working Paper. AN - 62329580; ED448387 AB - Findings from the National Household Survey on Drug Abuse (NHSDA) show a substantial decrease in alcohol use by youth during the past decade. Yet despite these trends, an estimated 1 in 5 teenagers were current alcohol drinkers and 1 in 13 were binge alcohol drinkers. This report provides data showing the relationship between emotional state, health, and behaviors of adolescents who use alcohol. Data from the 1994, 1995, and 1996 NHSDA surveys were used for this study, comprised of 17,821 respondents between the ages of 12 and 17. The data showed that there is a strong positive relationship between many reported problem behaviors and alcohol use among youths. Some of the relationships may have been due to confounding factors such as age; gender; race/ethnicity; family structure; income; mobility; and marijuana use in the past month. Even after controlling for these variables, there was a relationship between past month alcohol use and emotional and behavioral problems. It is not possible to determine whether the observed associations between alcohol use and behaviors can be explained by some other related behavioral or environmental factor. Other longitudinal studies are needed to determine if symptoms and behaviors preceded the alcohol use. (Contains 14 tables and 24 references.) (JDM) AU - Greenblatt, Janet C. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 38 KW - National Household Survey on Drug Abuse KW - ERIC, Resources in Education (RIE) KW - Drinking KW - Alcohol Abuse KW - Emotional Problems KW - Student Problems KW - National Surveys KW - Longitudinal Studies KW - Behavior Problems KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62329580?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Geologic, mineralogic, and mineral resource data in the Revett Formation; digital database for genetic study of stratiform copper-silver deposits in the Belt Basin, Idaho and Montana AN - 52225535; 2001-040788 AB - A digital geological database that consists of stratigraphic, mineralogic, and mineral resource information has been completed for the Revett Formation within a 85-mile by 100-mile study area. It will facilitate genetic studies of sediment-hosted copper-silver deposits within the Revett Formation and land-use planning on federal lands. The multi-part database consists of the following: 1) 110 stratigraphic-mineralogic log sections through the Revett (more than 122,000 feet of strata) derived from measured outcrop sections and diamond drill-holes (donated by industry); 2) detailed outcrop geologic and alteration mapping; 3) a description of 56 Revett-type mines and mineral occurrences; 4) mineral resource areas outlining the extent of mineralized rock at 28 of the 56 mine or mineral occurrence sites; and 5) the location of unexplored areas containing untested potential for finding additional Revett-type deposits. The unexplored areas cover significant parts of the study area and have many characteristics in common with proven areas. Databases of drill logs, maps, tables, spreadsheets, and attributed arcs and polygons are in digital formats for use in a geographic information system. Data collection, mineral paragenesis and stratigraphic practices follow previous studies at the Troy silver-copper mine (T. S. Hayes, written comm.). Based on preliminary analyses of the data, alteration effects related to mineralizing process were mappable from core and outcrop; conversely, lavender, calcite-bearing quartzites, the strata that make unsuitable hosts, can be similarly mapped and eliminated in order to focus future exploration work. Correlation of members and beds within the Revett Formation is possible over moderate distances and will be useful for future ore-stratigraphic-mineralogic analysis. JF - Abstracts with Programs - Geological Society of America AU - Boleneus, David E AU - Appelgate, Larry M AU - Chase, Derrick W AU - White, Brian G AU - Anonymous Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 3 PB - Geological Society of America (GSA), Boulder, CO VL - 32 IS - 5 SN - 0016-7592, 0016-7592 KW - United States KW - North America KW - Idaho KW - digital data KW - upper Precambrian KW - Precambrian KW - data processing KW - stratiform deposits KW - Proterozoic KW - mineralogy KW - Belt Basin KW - silver ores KW - mineral resources KW - Montana KW - Mesoproterozoic KW - Revett Quartzite KW - metal ores KW - data bases KW - copper ores KW - minerals KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52225535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Geologic%2C+mineralogic%2C+and+mineral+resource+data+in+the+Revett+Formation%3B+digital+database+for+genetic+study+of+stratiform+copper-silver+deposits+in+the+Belt+Basin%2C+Idaho+and+Montana&rft.au=Boleneus%2C+David+E%3BAppelgate%2C+Larry+M%3BChase%2C+Derrick+W%3BWhite%2C+Brian+G%3BAnonymous&rft.aulast=Boleneus&rft.aufirst=David&rft.date=2000-03-01&rft.volume=32&rft.issue=5&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Rocky Mountain Section, 52nd annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2001-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Belt Basin; copper ores; data bases; data processing; digital data; Idaho; Mesoproterozoic; metal ores; mineral resources; mineralogy; minerals; Montana; North America; Precambrian; Proterozoic; Revett Quartzite; silver ores; stratiform deposits; United States; upper Precambrian ER - TY - JOUR T1 - Localization of the Coeur d'Alene mining district at the juncture of the Lewis and Clark and Noxon lines AN - 52209744; 2001-040014 AB - The silver-lead-zinc veins of the Coeur d'Alene Mining District evidently formed in metamorphic shear zones and reverse faults within the Lewis and Clark line (LCL). However, a separate control is required to explain the concentration of ore bodies within this short segment of the line. We suggest that the control was provided by a second, long-lived, recurrently activated, north-trending lineament we call the Noxon line, which intersects the LCL in the Coeur d'Alene district. Synsedimentary faulting in the Noxon line is recorded by thickness and facies variations in various Belt strata. These variations reflect a feature we call the Noxon arch. Subsequent reactivation of basement structures responsible for the arch produced the Moyie fault and various subparallel reverse and normal faults and galena-sphalerite veins. These structures track the axis and west side of the arch from the vicinity of the Sullivan Mine in British Columbia to the heart of the Coeur d'Alene district. We propose that early synsedimentary faulting along the Noxon line localized extensive syngenetic zinc-lead-silver deposits in lower Prichard/Aldredge strata, while later diagenetic processes localized epigenetic, stratabound copper-silver deposits within the arch. These deposits extend into the Lewis and Clark line, where Cretaceous or early Tertiary tectonism redistributed the metals into the veins of the Coeur d'Alene district. JF - Abstracts with Programs - Geological Society of America AU - White, Brian G AU - Appelgate, Larry M AU - Anonymous Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 42 PB - Geological Society of America (GSA), Boulder, CO VL - 32 IS - 5 SN - 0016-7592, 0016-7592 KW - United States KW - mineral deposits, genesis KW - upper Precambrian KW - Cretaceous KW - Lewis and Clark Lineament KW - Sullivan Mine KW - Wallace Formation KW - silver ores KW - lower Tertiary KW - Cenozoic KW - tectonics KW - mines KW - lead ores KW - Precambrian KW - localization KW - zinc ores KW - British Columbia KW - Proterozoic KW - veins KW - metamorphism KW - Mesozoic KW - Mesoproterozoic KW - Tertiary KW - Coeur d'Alene mining district KW - Canada KW - Noxon Lineament KW - Revett Quartzite KW - metal ores KW - Western Canada KW - 16:Structural geology KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52209744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Localization+of+the+Coeur+d%27Alene+mining+district+at+the+juncture+of+the+Lewis+and+Clark+and+Noxon+lines&rft.au=White%2C+Brian+G%3BAppelgate%2C+Larry+M%3BAnonymous&rft.aulast=White&rft.aufirst=Brian&rft.date=2000-03-01&rft.volume=32&rft.issue=5&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Rocky Mountain Section, 52nd annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2001-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - British Columbia; Canada; Cenozoic; Coeur d'Alene mining district; Cretaceous; lead ores; Lewis and Clark Lineament; localization; lower Tertiary; Mesoproterozoic; Mesozoic; metal ores; metamorphism; mineral deposits, genesis; mines; Noxon Lineament; Precambrian; Proterozoic; Revett Quartzite; silver ores; Sullivan Mine; tectonics; Tertiary; United States; upper Precambrian; veins; Wallace Formation; Western Canada; zinc ores ER - TY - JOUR T1 - Mycobacterium septicum sp. nov., a new rapidly growing species associated with catheter-related bacteraemia AN - 17553299; 4733902 AB - Rapidly growing mycobacteria are capable of causing several clinical diseases in both immunosuppressed and immunocompetent individuals. A previously unidentified, rapidly growing mycobacterium was determined to be the causative agent of central line sepsis in a child with underlying metastatic hepatoblastoma. Four isolates of this mycobacterium, three from blood and one from the central venous catheter tip, were studied. Phenotypic characterization, HPLC and genetic analysis revealed that while this organism most closely resembled members of the Mycobacterium fortuitum complex and Mycobacterium senegalense, it differed from all previously described species. Phenotypic tests useful in differentiating this species from similar rapidly growing mycobacteria included: growth at 42 degrees C, hydrolysis of acetamide, utilization of citrate, production of arylsulfatase (3-d), acidification of D-mannitol and i-myo-inositol, and susceptibility to erythromycin, vancomycin and tobramycin. The name Mycobacterium septicum is proposed for this new species. The type strain has been deposited in Deutsche Sammlung von Mikroorganismen und Zellkulturen as DSM 44393(T) and in the American Type Culture Collection as strain ATCC 700731 (T). JF - International Journal of Systematic and Evolutionary Microbiology AU - Schinsky, M F AU - McNeil, M M AU - Whitney, A M AU - Steigerwalt, A G AU - Lasker, BA AU - Floyd, M M AU - Hogg, G G AU - Brenner, D J AU - Brown, J M AD - Meningitis and Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 575 EP - 581 PB - Society for General Microbiology VL - 50 IS - 2 SN - 1466-5026, 1466-5026 KW - Microbiology Abstracts B: Bacteriology KW - High-performance liquid chromatography KW - Mycobacterium senegalense KW - Tobramycin KW - Mycobacterium fortuitum KW - Drug sensitivity testing KW - Bacteremia KW - Erythromycin KW - Mycobacterium septicum KW - Phenotyping KW - Catheters KW - Vancomycin KW - Taxonomy KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17553299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.atitle=Mycobacterium+septicum+sp.+nov.%2C+a+new+rapidly+growing+species+associated+with+catheter-related+bacteraemia&rft.au=Schinsky%2C+M+F%3BMcNeil%2C+M+M%3BWhitney%2C+A+M%3BSteigerwalt%2C+A+G%3BLasker%2C+BA%3BFloyd%2C+M+M%3BHogg%2C+G+G%3BBrenner%2C+D+J%3BBrown%2C+J+M&rft.aulast=Schinsky&rft.aufirst=M&rft.date=2000-03-01&rft.volume=50&rft.issue=2&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.issn=14665026&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium septicum; Mycobacterium fortuitum; Mycobacterium senegalense; Catheters; Bacteremia; Phenotyping; Drug sensitivity testing; Erythromycin; Vancomycin; Tobramycin; High-performance liquid chromatography; Taxonomy ER - TY - JOUR T1 - Live Oral Poliovirus Vaccines do not Contain Detectable Simian Virus 40 (SV40) DNA AN - 17524644; 4709930 AB - Prior to 1962, poliovirus vaccines produced in rhesus monkey kidney cells were contaminated with SV40. Recent studies reporting the detection of SV40 in human tumours raised concern that SV40 may be oncogenic in humans. To provide further assurance that currently used poliovirus vaccines are not contaminated with SV40, we used the polymerase chain reaction (PCR) to search for SV40 DNA in live oral poliovirus vaccines manufactured in the United States between 1972 and 1996. SV40 DNA sequences were not found in any of the vaccine lots tested. JF - Biologicals AU - Sierra-Honigmann, A AU - Krause, PR AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A, Rm. 1C16, 29 Lincoln Drive, Bethesda, MD 20892, U.S.A. Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 1 EP - 4 PB - Academic Press VL - 28 IS - 1 SN - 1045-1056, 1045-1056 KW - USA KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Poliovirus KW - Attenuation KW - Quality control KW - DNA KW - Simian virus 40 KW - Polymerase chain reaction KW - Vaccines KW - V 22097:Immunization: Vaccines & vaccination: Human KW - A 01097:Viruses KW - A 01073:Quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17524644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Live+Oral+Poliovirus+Vaccines+do+not+Contain+Detectable+Simian+Virus+40+%28SV40%29+DNA&rft.au=Sierra-Honigmann%2C+A%3BKrause%2C+PR&rft.aulast=Sierra-Honigmann&rft.aufirst=A&rft.date=2000-03-01&rft.volume=28&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Poliovirus; Simian virus 40; Quality control; Polymerase chain reaction; DNA; Attenuation; Vaccines ER - TY - JOUR T1 - Evaluation of Vaccines, Interferons and Cell Substrates for Pestivirus Contamination AN - 17522984; 4709935 AB - Pestiviruses are potential contaminants of biological products produced in bovine or porcine cells or manufactured via processes using animal-derived raw materials such as bovine serum. In order to investigate possible contamination of products including those manufactured and/or licensed in the US, 38 lots of viral vaccines and five lots of interferon alpha (IFN alpha ) were tested by reverse transcriptase polymerase chain reaction (RT-PCR) for the presence of bovine viral diarrhoea virus (BVDV). All vaccines and interferons were negative for contaminating BVDV RNA when tested by RT-PCR, with the exception of an experimental live viral vaccine that had been produced in BVDV contaminated rabbit kidney cells. Cell lines commonly used to produce biological products and vaccines were experimentally infected with the NADL strain of BVDV to determine if they were permissive for virus replication. MRC-5 and Wl-38 cells were not infected. In contrast, Vero, CHO and CEF cells showed evidence of pestivirus infection. Taken together these data suggested that currently licensed viral vaccines were unlikely to be contaminated with pestiviruses. However, cell banks derived from non-human primate, hamster or rabbit kidney cell lines, or cultures of primary chick embryo fibroblasts, may be infected with BVDV if exposed to pestivirus contaminated raw materials during manufacture. JF - Biologicals AU - Audet, SA AU - Crim, R L AU - Beeler, J AD - FDA/CBER, 1401 Rockville Pike (HFM-463), Rockville, Maryland 20852, U.S.A., beeler@cber.fda.gov Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 41 EP - 46 PB - Academic Press VL - 28 IS - 1 SN - 1045-1056, 1045-1056 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - ^a-Interferon KW - Pestivirus KW - Bovine viral diarrhea virus KW - RNA viruses KW - Cell culture KW - Reverse transcription KW - Quality control KW - Polymerase chain reaction KW - Vaccines KW - a-Interferon KW - V 22097:Immunization: Vaccines & vaccination: Human KW - A 01097:Viruses KW - A 01073:Quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17522984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Evaluation+of+Vaccines%2C+Interferons+and+Cell+Substrates+for+Pestivirus+Contamination&rft.au=Audet%2C+SA%3BCrim%2C+R+L%3BBeeler%2C+J&rft.aulast=Audet&rft.aufirst=SA&rft.date=2000-03-01&rft.volume=28&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bovine viral diarrhea virus; Pestivirus; Cell culture; RNA viruses; Reverse transcription; Polymerase chain reaction; Vaccines; a-Interferon; Quality control; ^a-Interferon ER - TY - JOUR T1 - Differential bacterial survival, replication, and apoptosis-inducing ability of Salmonella serovars within human and murine macrophages AN - 17494812; 4687713 AB - Salmonella serovars are associated with human diseases that range from mild gastroenteritis to host-disseminated enteric fever. Human infections by Salmonella enterica serovar Typhi can lead to typhoid fever, but this serovar does not typically cause disease in mice or other animals. In contrast, S. enterica serovar Typhimurium and S. enterica serovar Enteritidis, which are usually linked to localized gastroenteritis in humans and some animal species, elicit a systemic infection in mice. To better understand these observations, multiple strains of each of several chosen serovars of Salmonella were tested for the ability in the nonopsonized state to enter, survive, and replicate within human macrophage cells (U937 and elutriated primary cells) compared with murine macrophage cells (J774A.1 and primary peritoneal cells); in addition, death of the infected macrophages was monitored. The serovar Typhimurium strains all demonstrated enhanced survival within J774A.1 cells and murine peritoneal macrophages, compared with the significant, almost 100-fold declines in viable counts noted for serovar Typhi strains. Viable counts for serovar Enteritidis either matched the level of serovar Typhi (J774A.1 macrophages) or were comparable to counts for serovar Typhimurium (murine peritoneal macrophages). Apoptosis was significantly higher in J774A.1 cells infected with serovar Typhimurium strain LT2 compared to serovar Typhi strain Ty2. On the other hand, serovar Typhi survived at a level up to 100-fold higher in elutriated human macrophages and 2- to 3-fold higher in U937 cells compared to the serovar Typhimurium and Enteritidis strains tested. Despite the differential multiplication of serovar Typhi during infection of U937 cells, serovar Typhi caused significantly less apoptosis than infections with serovar Typhimurium. These observations indicate variability in intramacrophage survival and host cytotoxicity among the various serovars and are the first to show differences in the apoptotic response of distinct Salmonella serovars residing in human macrophage cells. These studies suggest that nonopsonized serovar Typhimurium enters, multiplies within, and causes considerable, acute death of macrophages, leading to a highly virulent infection in mice (resulting in death within 14 days). In striking contrast, nonopsonized serovar Typhi survives silently and chronically within human macrophages, causing little cell death, which allows for intrahost dissemination and typhoid fever (low host mortality). The type of disease associated with any particular serovar of Salmonella is linked to the ability of that serovar both to persist within and to elicit damage in a specific host's macrophage cells. JF - Infection and Immunity AU - Schwan, W R AU - Huang, X-Z AU - Hu, L AU - Kopecko, D J AD - Laboratory of Enteric and Sexually Transmitted Diseases, HFM440, Food and Drug Administration, Center for Biologics Evaluation and Research, NIH Campus, Bldg. 29/420, Bethesda, MD 20892, USA, kopecko@cber.fda.gov Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 1005 EP - 1013 VL - 68 IS - 3 SN - 0019-9567, 0019-9567 KW - man KW - mice KW - immunology KW - survival KW - Salmonella KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Cytotoxicity KW - Serotypes KW - Apoptosis KW - Replication KW - Salmonella enterica KW - Cell culture KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms KW - F 06764:Function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17494812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Differential+bacterial+survival%2C+replication%2C+and+apoptosis-inducing+ability+of+Salmonella+serovars+within+human+and+murine+macrophages&rft.au=Schwan%2C+W+R%3BHuang%2C+X-Z%3BHu%2C+L%3BKopecko%2C+D+J&rft.aulast=Schwan&rft.aufirst=W&rft.date=2000-03-01&rft.volume=68&rft.issue=3&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.3.1005-1013.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella enterica; Macrophages; Apoptosis; Replication; Cell culture; Cytotoxicity; Serotypes DO - http://dx.doi.org/10.1128/IAI.68.3.1005-1013.2000 ER - TY - JOUR T1 - Site-specific modifications and toxicity of blood substitutes. The case of diaspirin cross-linked hemoglobin. AN - 71163434; 10837790 AB - Safe and effective hemoglobin-based blood substitutes may be advantageous over conventional therapies for certain clinical settings requiring short term blood replacement such as emergency resuscitation and hemodilution in surgery. Many advances have been made in developing these oxygen therapeutics, however safety concerns continue to slow their clinical progress. An important and often overlooked consideration in evaluating the safety of modified hemoglobins is the impact of chemical and/or genetic modifications on the redox chemistry of these proteins. Diaspirin cross-linked hemoglobin (DBBF-Hb) has been extensively evaluated in vitro and in animal models, and thus represents a useful model to explore possible correlations between structural-functional alterations and toxicity of hemoglobin-based blood substitutes. JF - Advanced drug delivery reviews AU - D'Agnillo, F AU - Alayash, A I AD - Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000/02/28/ PY - 2000 DA - 2000 Feb 28 SP - 199 EP - 212 VL - 40 IS - 3 SN - 0169-409X, 0169-409X KW - Blood Substitutes KW - 0 KW - Hemoglobins KW - diaspirin-cross-linked hemoglobin KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - Blood Substitutes -- chemistry KW - Hemoglobins -- toxicity KW - Aspirin -- chemistry KW - Aspirin -- analogs & derivatives KW - Aspirin -- toxicity KW - Hemoglobins -- chemistry KW - Blood Substitutes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71163434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+drug+delivery+reviews&rft.atitle=Site-specific+modifications+and+toxicity+of+blood+substitutes.+The+case+of+diaspirin+cross-linked+hemoglobin.&rft.au=D%27Agnillo%2C+F%3BAlayash%2C+A+I&rft.aulast=D%27Agnillo&rft.aufirst=F&rft.date=2000-02-28&rft.volume=40&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Advanced+drug+delivery+reviews&rft.issn=0169409X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-18 N1 - Date created - 2000-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Health Outcomes among Hispanic Subgroups: Data from the National Health Interview Survey, 1992-95. Advance Data, Number 310. AN - 62418794; ED438393 AB - In this report, various health measures are compared across Hispanic subgroups in the United States. National Health Interview Survey (NHIS) data aggregated from 1992 through 1995 were analyzed. NHIS is one of the few national surveys that has a sample sufficiently large enough to allow such comparisons. Both age-adjusted and unadjusted estimates of several health outcomes are compared for Mexican, Cuban, Puerto Rican, and "other Hispanic" subgroups. The health indicators for Puerto Ricans are significantly worse than for other Hispanic origin subgroups. In contrast, the health indicators for Cubans are often better than those of the other subgroups. Mexican subgroup members fare better than Puerto Ricans on measures such as days of restricted activity, bed disability days, and hospitalizations. The data demonstrate clear difference in health status as well as indicators of socioeconomic status across Hispanic subgroups in the United States. Data on Hispanic subgroups can facilitate the planning of public health services for various underserved populations. (Contains 3 figures, 10 tables, and 22 references.) (SLD) AU - Hajat, Anjum AU - Lucas, Jacqueline B. AU - Kington, Raynard Y1 - 2000/02/25/ PY - 2000 DA - 2000 Feb 25 SP - 16 PB - U.S. Department of Health and Human Services, Center for Disease Control and Prevention, National Center for Health Statistics, 6525 Belcrest Road, Hyattsville, Maryland 20782-2003. Tel: 301-458-4636; email: nchsquery@cec.gov. Web site: www.cdc.gov/nchs/. KW - Health Status KW - National Health Interview Survey KW - ERIC, Resources in Education (RIE) KW - Low Income Groups KW - Hispanic Americans KW - Urban Areas KW - Socioeconomic Status KW - Health KW - Interviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62418794?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Tumorigenicity of morphologically distinct transformed foci induced by 3-methylcholanthrene in BALB/c-3T3 cells. AN - 71012217; 10751612 AB - 4 mm in diameter), invasiveness (smooth vs. invading margins) and other properties (piling vs. spread). In our previous report, we showed that cells from all five types grew in soft agar, transformed normal NIH 3T3 cells and formed foci on normal layer of BALB/c-3T3 cells. In this study, the neoplastic/tumorigenic potential of cells from the five different types of transformed foci was investigated in nude mice. About two million cells from each transformed focus were injected into 4-week-old nude mice. Non-transformed BALB/c-3T3 cells were used as control. The results of this study indicate that all the 45 athymic mice injected with different transformants developed tumors between 2 and 4 weeks after injection. Tumors were not observed in eight mice injected with non-transformed BALB/c-3T3 cells. All tumors were histopathologically confirmed fibrosarcomas. These findings indicate that all five morphologically different foci show tumorigenicity and that any foci of size > or =2 mm regardless of invasiveness and piling could be scored as positive during the cell transformation assay. JF - Mutation research AU - Keshava, N AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA. ndk2@cdc.gov Y1 - 2000/02/14/ PY - 2000 DA - 2000 Feb 14 SP - 281 EP - 286 VL - 447 IS - 2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Methylcholanthrene KW - 56-49-5 KW - Index Medicus KW - Neoplasm Invasiveness KW - Animals KW - 3T3 Cells KW - Sarcoma, Experimental -- chemically induced KW - Carcinogens -- toxicity KW - Sarcoma, Experimental -- pathology KW - Mice, Nude KW - Mice KW - Cell Line, Transformed KW - Mice, Inbred BALB C KW - Female KW - Cell Transformation, Neoplastic -- pathology KW - Methylcholanthrene -- toxicity KW - Fibrosarcoma -- chemically induced KW - Cell Transformation, Neoplastic -- chemically induced KW - Fibrosarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71012217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Tumorigenicity+of+morphologically+distinct+transformed+foci+induced+by+3-methylcholanthrene+in+BALB%2Fc-3T3+cells.&rft.au=Keshava%2C+N&rft.aulast=Keshava&rft.aufirst=N&rft.date=2000-02-14&rft.volume=447&rft.issue=2&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-17 N1 - Date created - 2000-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation. AN - 70885688; 10650149 AB - Methamphetamine (METH) has been known to produce neurotoxicity via generation of reactive oxygen and nitrogen species. Selenium, an antioxidant, was reported to protect against METH-induced dopaminergic neurotoxicity in mouse caudate nucleus. In the present study, the in vitro and in vivo efficacy of the supplementation of selenium was studied in METH-induced generation of peroxynitrite. PC12 cell cultures were exposed to 200 microM METH either with or without 10 microM and 20 microM selenium (30 min prior to METH exposure). After 24 h, METH exposure resulted in the significant depletion of dopamine, and its metabolites DOPAC and HVA, as well as the significant formation of 3-nitrotyrosine (3-NT), a marker of peroxynitrite generation, in PC12 cell cultures. Selenium supplementation attenuated the depletion of dopamine and its metabolites, DOPAC and HVA and the formation of 3-NT in PC12 cells. For in vivo studies, adult male mice were supplemented with selenium in drinking water, 1 week before and 1 week after the multiple injections of METH (4x10 mg/kg, i.p. at 2-h interval) or an equivalent volume of saline. The supplementation of Se attenuated the formation of 3-NT in the striatum resulting from METH treatment. These data suggest that METH-induced neurotoxicity is mediated by the production of peroxynitrite, and selenium plays a protective role in METH-induced neurotoxicity. JF - Brain research AU - Imam, S Z AU - Ali, S F AD - Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/USFDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2000/02/07/ PY - 2000 DA - 2000 Feb 07 SP - 186 EP - 191 VL - 855 IS - 1 SN - 0006-8993, 0006-8993 KW - Antioxidants KW - 0 KW - Neurotoxins KW - Neurotrophin 3 KW - Nitrates KW - Oxidants KW - Sympathomimetics KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - peroxynitric acid KW - 26404-66-0 KW - Methamphetamine KW - 44RAL3456C KW - Selenium KW - H6241UJ22B KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Rats KW - Animals KW - Caudate Nucleus -- metabolism KW - Neurotrophin 3 -- metabolism KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Mice, Inbred C57BL KW - Caudate Nucleus -- drug effects KW - Mice KW - Homovanillic Acid -- metabolism KW - Neurotoxins -- toxicity KW - Male KW - PC12 Cells KW - Sympathomimetics -- toxicity KW - Antioxidants -- pharmacology KW - Nitrates -- metabolism KW - Selenium -- pharmacology KW - Dopamine -- metabolism KW - Oxidants -- metabolism KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70885688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Selenium%2C+an+antioxidant%2C+attenuates+methamphetamine-induced+dopaminergic+toxicity+and+peroxynitrite+generation.&rft.au=Imam%2C+S+Z%3BAli%2C+S+F&rft.aulast=Imam&rft.aufirst=S&rft.date=2000-02-07&rft.volume=855&rft.issue=1&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-17 N1 - Date created - 2000-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of hypoxia and glutathione depletion on hemoglobin- and myoglobin-mediated oxidative stress toward endothelium. AN - 70883436; 10656972 AB - We investigated the toxicity of hemoglobin/myoglobin on endothelial cells under oxidative stress conditions that include cellular hypoxia and reduced antioxidant capacity. Bovine aorta endothelial cells (BAECs), grown on microcarrier beads, were subjected to cycles of hypoxia and reoxygenation in a small volume of medium, and endothelial cell monolayers were depleted of their intracellular glutathione (GSH) by treatment with buthionine sulfoximine. Incubation of diaspirin cross-linked hemoglobin (DBBF-Hb) or horse skeletal myoglobin (Mb) with BAECs subjected to 3 h of hypoxia caused transient oxidation of the hemoproteins to the ferryl form (Fe(4+)). Formation of the ferryl intermediate was decreased in a concentration-dependent manner by the addition of L-arginine, a substrate of NO synthase, after 3 h of hypoxia. Optimal inhibition of ferryl formation, possibly due to the antioxidant action of NO, was achieved with 900 microM L-arginine. Addition of hydrogen peroxide to GSH-depleted cells in the presence of DBBF-Hb or Mb significantly decreased cell viability. Ferryl Mb, but not ferryl DBBF-Hb, was observed in samples analyzed at the end of treatment, which may explain the greater toxicity observed with Mb as opposed to DBBF-Hb. This model may be utilized to identify causative agent(s) associated with hemoprotein cytotoxicity and in designing strategies to suppress or control heme-mediated injury under physiologically relevant conditions. JF - Biochimica et biophysica acta AU - D'Agnillo, F AU - Wood, F AU - Porras, C AU - Macdonald, V W AU - Alayash, A I AD - Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bldg. 29, Rm. 112, Bethesda, MD 20892, USA. Y1 - 2000/02/02/ PY - 2000 DA - 2000 Feb 02 SP - 150 EP - 159 VL - 1495 IS - 2 SN - 0006-3002, 0006-3002 KW - Myoglobin KW - 0 KW - bis(3,5-dibromosalicyl)fumarate-crosslinked hemoglobin A(0) KW - Hemoglobin A KW - 9034-51-9 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glutathione KW - GAN16C9B8O KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Animals KW - Cattle KW - Cells, Cultured KW - Aspirin -- analogs & derivatives KW - Oxidative Stress KW - Hydrogen Peroxide -- pharmacology KW - Lipid Peroxidation -- drug effects KW - Spectrophotometry KW - Hemoglobin A -- pharmacology KW - Aspirin -- pharmacology KW - Myoglobin -- pharmacology KW - Cell Survival KW - Endothelium, Vascular -- metabolism KW - Glutathione -- deficiency KW - Cell Hypoxia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70883436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Effects+of+hypoxia+and+glutathione+depletion+on+hemoglobin-+and+myoglobin-mediated+oxidative+stress+toward+endothelium.&rft.au=D%27Agnillo%2C+F%3BWood%2C+F%3BPorras%2C+C%3BMacdonald%2C+V+W%3BAlayash%2C+A+I&rft.aulast=D%27Agnillo&rft.aufirst=F&rft.date=2000-02-02&rft.volume=1495&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-02 N1 - Date created - 2000-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liquid chromatographic method for fumonisin B1 in sorghum syrup and corn-based breakfast cereals. AN - 71083633; 10793847 AB - The fungus Fusarium verticillioides has been found on corn and sorghum, so it is possible that one or more of these toxins may be found in corn products such as breakfast cereals and syrup prepared from sorghum. Published methods when applied to syrups spiked with fumonisins gave low recoveries, less than 50%. A method was therefore developed which would be applicable to the syrup and breakfast cereals as well. Test samples were extracted with methanol-0.1 M sodium phosphate buffer (pH3) (1 + 1). The extract was diluted with water and applied to a 1 g C18 column. The column was washed with acetonitrile-water (2 + 8). Fumonisin B1 (FB1) was eluted with acetonitrile-trifluoroacetic acid (1000 + 1). The purified extract was evaporated and the toxin was derivatized with ophthaldialdehyde mercaptoethanol. The reaction mixture was resolved on a C18 liquid chromatographic column using acetonitrile-water-acetic acid (500 + 550 + 10.5) as the mobile phase at 37 degrees C, and FB1 measured with a fluorescence detector (excitation 335 nm, emission 440 nm). Recoveries of FB1 added to samples of sorghum syrup at levels ranging from 0.1 to 1.0 microgram/g were 94-132%. Recoveries of FB1 added to samples of breakfast cereal (corn flakes) at levels ranging from 0.2 to 1.6 micrograms/g were 96-100%. The method was applied to the analysis of 35 samples of sorghum syrup collected from 15 states in the US. One sample was found to contain FB1 at 0.12 microgram/g. A total of 32 samples of breakfast cereals collected by the Food and Drug Administration inspectors from grocery stores around the Kansas City area were analysed; no FB1 was found in the breakfast cereals (< 0.01 microgram/g). Results of this study indicated that FB1 possibly is not a problem in sorghum syrup and corn-based breakfast cereals in the US. JF - Food additives and contaminants AU - Trucksess, M W AU - Cho, T H AU - Ready, D E AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 161 EP - 166 VL - 17 IS - 2 SN - 0265-203X, 0265-203X KW - Biomarkers KW - 0 KW - Carboxylic Acids KW - Carcinogens KW - Fumonisins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Edible Grain -- chemistry KW - Food Contamination -- analysis KW - Carcinogens -- analysis KW - Carboxylic Acids -- analysis KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71083633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Liquid+chromatographic+method+for+fumonisin+B1+in+sorghum+syrup+and+corn-based+breakfast+cereals.&rft.au=Trucksess%2C+M+W%3BCho%2C+T+H%3BReady%2C+D+E&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2000-02-01&rft.volume=17&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-22 N1 - Date created - 2000-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer risk estimation for mixtures of coal tars and benzo(a)pyrene. AN - 71082662; 10795341 AB - Two-year chronic bioassays were conducted by using B6C3F1 female mice fed several concentrations of two different mixtures of coal tars from manufactured gas waste sites or benzo(a)pyrene (BaP). The purpose of the study was to obtain estimates of cancer potency of coal tar mixtures, by using conventional regulatory methods, for use in manufactured gas waste site remediation. A secondary purpose was to investigate the validity of using the concentration of a single potent carcinogen, in this case benzo(a)pyrene, to estimate the relative risk for a coal tar mixture. The study has shown that BaP dominates the cancer risk when its concentration is greater than 6,300 ppm in the coal tar mixture. In this case the most sensitive tissue site is the forestomach. Using low-dose linear extrapolation, the lifetime cancer risk for humans is estimated to be: Risk < 1.03 x 10(-4) (ppm coal tar in total diet) + 240 x 10(-4) (ppm BaP in total diet), based on forestomach tumors. If the BaP concentration in the coal tar mixture is less than 6,300 ppm, the more likely case, then lung tumors provide the largest estimated upper limit of risk, Risk < 2.55 x 10(-4) (ppm coal tar in total diet), with no contribution of BaP to lung tumors. The upper limit of the cancer potency (slope factor) for lifetime oral exposure to benzo(a)pyrene is 1.2 x 10(-3) per microgram per kg body weight per day from this Good Laboratory Practice (GLP) study compared with the current value of 7.3 x 10(-3) per microgram per kg body weight per day listed in the U.S. EPA Integrated Risk Information System. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Gaylor, D W AU - Culp, S J AU - Goldstein, L S AU - Beland, F A AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 81 EP - 85 VL - 20 IS - 1 SN - 0272-4332, 0272-4332 KW - Carcinogens KW - 0 KW - Gases KW - Industrial Waste KW - Benzo(a)pyrene KW - 3417WMA06D KW - Coal Tar KW - 8007-45-2 KW - Index Medicus KW - United States KW - Animals KW - United States Environmental Protection Agency KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Humans KW - Mice KW - Body Weight KW - Risk KW - Mice, Inbred Strains KW - Stomach Neoplasms -- chemically induced KW - Environmental Exposure KW - Incidence KW - Lung Neoplasms -- chemically induced KW - Female KW - Industrial Waste -- adverse effects KW - Neoplasms, Experimental -- chemically induced KW - Benzo(a)pyrene -- adverse effects KW - Coal Tar -- adverse effects KW - Risk Assessment KW - Carcinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71082662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Cancer+risk+estimation+for+mixtures+of+coal+tars+and+benzo%28a%29pyrene.&rft.au=Gaylor%2C+D+W%3BCulp%2C+S+J%3BGoldstein%2C+L+S%3BBeland%2C+F+A&rft.aulast=Gaylor&rft.aufirst=D&rft.date=2000-02-01&rft.volume=20&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-23 N1 - Date created - 2000-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast-feeding exposure of infants to selected pesticides: a public health viewpoint. AN - 71082151; 10798624 AB - In this paper, we provide an overview of the public health implications of exposure to some pesticides via breast milk and provide health-based guidance. The presence of organochlorine pesticides in breast milk has been documented in many studies around the world. Included in our review are aldrin/dieldrin, chlordane, 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (DDT)/1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), endrin, hexachlorobenzene (HCB), and hexachlorocyclohexane (HCH). Toxicological and environmental data on these chemicals are compiled in toxicological profiles published by the Agency for Toxic Substances and Disease Registry (ATSDR). Based on the data, ATSDR derives chemical-specific minimal risk levels (MRLs) that assist in evaluating public health risks associated with exposure. MRLs are health-based guidance values designed to protect the most sensitive populations, including breast-fed infants. We compare MRLs and projected intakes from the breast milk for the listed pesticides, explore the possibilities of toxicological interactions, and provide health-based recommendations. JF - Toxicology and industrial health AU - Pohl, H R AU - Tylenda, C A AD - Division of Toxicology, Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 65 EP - 77 VL - 16 IS - 2 SN - 0748-2337, 0748-2337 KW - Pesticides KW - 0 KW - Index Medicus KW - Global Health KW - Humans KW - Infant, Newborn KW - Female KW - Risk Assessment KW - Breast Feeding -- adverse effects KW - Public Health KW - Milk, Human KW - Child Development -- drug effects KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71082151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Breast-feeding+exposure+of+infants+to+selected+pesticides%3A+a+public+health+viewpoint.&rft.au=Pohl%2C+H+R%3BTylenda%2C+C+A&rft.aulast=Pohl&rft.aufirst=H&rft.date=2000-02-01&rft.volume=16&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-30 N1 - Date created - 2000-06-30 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Biases in estimating the effect of cumulative exposure in log-linear models when estimated exposure levels are assigned. AN - 71016589; 10744176 AB - Exposure-response trends in occupational studies of chronic disease are often modeled via log-linear models with cumulative exposure as the metric of interest. Exposure levels for most subjects are often unknown, but can be estimated by assigning known job-specific mean exposure levels from a sample of workers to all workers. Such assignment results in (nondifferential) measurement error of the Berkson type, which does not bias the estimate of exposure effect in linear models but can result in substantial bias in log-linear models with dichotomous outcomes. This bias was explored in estimated exposure-response trends using cumulative exposure. Simulations were conducted under the assumptions that (i) exposure level is assigned to all workers based on the job-specific means from a sample of workers, (ii) exposure level and duration are log-normal, (iii) the true exposure-response model is log-linear for cumulative exposure, (iv) the disease is rare, and (v) the variance of job-specific exposure level increases with its job-specific mean. Results Assignment of job-specific mean exposure levels from a sample of workers causes an upward bias in the estimated exposure-response trend when there is little variance in the duration of exposure but causes a downward bias when duration has a large variance. This bias can be substantial (eg, 30-50%). Berkson errors in exposure result in little bias in estimating exposure-response trends when the standard deviation of duration is approximately equal to its mean, which is common in many occupational studies. No bias occurs when the variance of exposure level is constant across jobs, but such conditions are probably uncommon. JF - Scandinavian journal of work, environment & health AU - Steenland, K AU - Deddens, J A AU - Zhao, S AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. kns1@cdc.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 37 EP - 43 VL - 26 IS - 1 SN - 0355-3140, 0355-3140 KW - Index Medicus KW - Regression Analysis KW - Humans KW - Models, Statistical KW - Occupational Exposure -- statistics & numerical data KW - Observer Variation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71016589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Biases+in+estimating+the+effect+of+cumulative+exposure+in+log-linear+models+when+estimated+exposure+levels+are+assigned.&rft.au=Steenland%2C+K%3BDeddens%2C+J+A%3BZhao%2C+S&rft.aulast=Steenland&rft.aufirst=K&rft.date=2000-02-01&rft.volume=26&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-19 N1 - Date created - 2000-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of human and rodent lung dosimetry models for particle clearance and retention. AN - 70967860; 10711398 AB - Interspecies differences in the kinetics and/or mechanisms of particle retention can influence the amount and location of particle retention in the lungs, which can also influence the tissue response to a given particle burden. Dosimetric models may be used to adjust for differences in the exposure-dose relationships in different species, thus allowing for comparison of lung responses at equivalent doses. Although the rat is one of the most frequently used animal models for assessing the risk of exposures to hazardous substances in humans, few data are available for comparison of human and animal responses to inhaled particles. A biologically-based human dosimetric lung model was developed to describe the fate of respirable particles in the lungs of humans, using data from U.S. coal miners and assumptions about the overloading of alveolar clearance from studies in rats. This model includes alveolar, interstitial, and hilar lymph node compartments. The form of the model that provides the best fit to the lung dust burden data in these coal miners includes a first-order interstitialization process and either no dose-dependent decline in alveolar clearance or much less decline than expected from rodent studies. These findings are consistent with the particle retention patterns observed previously in the lungs of primates. This human lung dosimetry model is useful for investigating the factors that may influence the relationships between the airborne particle exposure, lung dust burden, and fibrotic lung disease. JF - Drug and chemical toxicology AU - Kuempel, E D AD - Risk Evaluation Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA. edkl@cdc.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 203 EP - 222 VL - 23 IS - 1 SN - 0148-0545, 0148-0545 KW - Air Pollutants KW - 0 KW - Air Pollutants, Occupational KW - Coal KW - Dust KW - Index Medicus KW - Animals KW - Lymph Nodes -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Metabolic Clearance Rate KW - Coal Mining KW - Models, Biological KW - Risk Assessment KW - Rats KW - Middle Aged KW - Species Specificity KW - Male KW - Lung -- metabolism KW - Air Pollutants, Occupational -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70967860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Comparison+of+human+and+rodent+lung+dosimetry+models+for+particle+clearance+and+retention.&rft.au=Kuempel%2C+E+D&rft.aulast=Kuempel&rft.aufirst=E&rft.date=2000-02-01&rft.volume=23&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-29 N1 - Date created - 2000-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and utilization of primary hepatocyte culture systems to evaluate metabolism, DNA binding, and DNA repair of xenobiotics. AN - 70956484; 10711405 AB - The use of isolated hepatocytes as an approach to evaluate hepatotoxic and hepatocarcinogenic compounds and investigate mechanisms by which chemicals induce liver lesions is well established. This review discusses techniques developed in the author's laboratory describing (1) isolation and primary culture of rodent hepatocytes detailing methods which are optimal for obtaining large numbers of viable cells, (2) DNA damage induced by physical and chemical agents in rodent hepatocytes measured as unscheduled DNA synthesis, and (3) metabolic activation of model hepatocarcinogens, their binding to DNA, and identification of individual adducts thought to be responsible for induction of DNA repair. JF - Drug metabolism reviews AU - Casciano, D A AD - National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology Jefferson, Arkansas 72079, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 1 EP - 13 VL - 32 IS - 1 SN - 0360-2532, 0360-2532 KW - DNA Adducts KW - 0 KW - Xenobiotics KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - DNA Adducts -- analysis KW - DNA Damage KW - Cells, Cultured KW - Biotransformation KW - Gene Expression KW - Mice KW - Liver -- cytology KW - DNA Repair KW - Liver -- drug effects KW - Xenobiotics -- metabolism KW - DNA -- metabolism KW - Liver -- metabolism KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70956484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Development+and+utilization+of+primary+hepatocyte+culture+systems+to+evaluate+metabolism%2C+DNA+binding%2C+and+DNA+repair+of+xenobiotics.&rft.au=Casciano%2C+D+A&rft.aulast=Casciano&rft.aufirst=D&rft.date=2000-02-01&rft.volume=32&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-23 N1 - Date created - 2000-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mercury induces regional and cell-specific stress protein expression in rat kidney. AN - 70937991; 10696793 AB - Cells respond to physiologic stress by enhancing the expression of specific stress proteins. Heat-shock proteins (hsps) and glucose-regulated proteins (grps) are members of a large superfamily of proteins collectively referred to as stress proteins. This particular stress-protein response has evolved as a cellular strategy to protect, repair, and chaperone other essential cellular proteins. The objective of this study was to evaluate the differential expression of four hsps in the renal cortex and medulla during experimental nephrotoxic injury using HgCl2. Male Sprague-Dawley rats received single injections of HgCl2 (0.25, 0.5, or 1 mg Hg/kg, i.v.). At 4, 8, 16, or 24 h after exposure, kidneys were removed and processed for histopathologic, immunoblot, and immunohistochemical analyses. Nephrosis was characterized as minimal or mild (cytoplasmic condensation, tubular epithelial degeneration, single cell necrosis) at the lower exposures, and progressed to moderate or severe (nuclear pyknosis, necrotic foci, sloughing of the epithelial casts into tubular lumens) at the highest exposures. Western blots of renal proteins were probed with monoclonal antibodies specific for 4 hsps. In whole kidney, Hg(II) induced a time- and dose-related accumulation of hsp72 and grp94. Accumulation of hsp72 was predominantly localized in the cortex and not medulla, while grp94 accumulated primarily in the medulla but not cortex. The high, constitutive expression of hsp73 did not change as a result of Hg(II) exposure, and it was equally localized in cortex and medulla. Hsp90 was not detected in kidneys of control or Hg-treated rats. Since hsp72 has been shown involved in cellular repair and recovery, and since Hg(II) damage occurs primarily in cortex, we investigated the cell-specific expression of this hsp. Hsp72 accumulated primarily in undamaged distal convoluted tubule epithelia, with less accumulation in undamaged proximal convoluted-tubule epithelia. These results demonstrate that expression of specific stress proteins in rat kidney exhibits regional heterogeneity in response to Hg(II) exposure, and a positive correlation exists between accumulation of some stress proteins and acute renal cell injury. While the role of accumulation of hsps and other stress proteins in vivo prior to or concurrent with nephrotoxicity remains to be completely understood, these stress proteins may be part of a cellular defense response to nephrotoxicants. Conversely, renal tubular epithelial cells that do not or are unable to express stress proteins, such as hsp72, may be more susceptible to nephrotoxicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Goering, P L AU - Fisher, B R AU - Noren, B T AU - Papaconstantinou, A AU - Rojko, J L AU - Marler, R J AD - Health Sciences Branch, Division of Life Sciences, Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland 20857, USA. plg@cdrh.fda.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 447 EP - 457 VL - 53 IS - 2 SN - 1096-6080, 1096-6080 KW - Carrier Proteins KW - 0 KW - HSC70 Heat-Shock Proteins KW - HSP70 Heat-Shock Proteins KW - HSP72 Heat-Shock Proteins KW - HSP90 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Hspa8 protein, rat KW - Membrane Proteins KW - glucose-regulated proteins KW - Mercuric Chloride KW - 53GH7MZT1R KW - Index Medicus KW - Rats KW - HSP90 Heat-Shock Proteins -- biosynthesis KW - Antibody Specificity KW - Animals KW - Rats, Sprague-Dawley KW - HSP70 Heat-Shock Proteins -- biosynthesis KW - Fluorescent Antibody Technique, Indirect KW - Electrophoresis, Polyacrylamide Gel KW - Membrane Proteins -- biosynthesis KW - Male KW - Carrier Proteins -- biosynthesis KW - Kidney Cortex -- drug effects KW - Kidney Medulla -- metabolism KW - Kidney Medulla -- drug effects KW - Kidney Cortex -- pathology KW - Heat-Shock Proteins -- biosynthesis KW - Mercuric Chloride -- toxicity KW - Nephrosis -- pathology KW - Kidney Cortex -- metabolism KW - Nephrosis -- metabolism KW - Nephrosis -- chemically induced KW - Kidney Medulla -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70937991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Mercury+induces+regional+and+cell-specific+stress+protein+expression+in+rat+kidney.&rft.au=Goering%2C+P+L%3BFisher%2C+B+R%3BNoren%2C+B+T%3BPapaconstantinou%2C+A%3BRojko%2C+J+L%3BMarler%2C+R+J&rft.aulast=Goering&rft.aufirst=P&rft.date=2000-02-01&rft.volume=53&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-17 N1 - Date created - 2000-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approaches for identifying and defining environmentally associated rheumatic disorders. AN - 70928836; 10693862 JF - Arthritis and rheumatism AU - Miller, F W AU - Hess, E V AU - Clauw, D J AU - Hertzman, P A AU - Pincus, T AU - Silver, R M AU - Mayes, M D AU - Varga, J AU - Medsger, T A AU - Love, L A AD - Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 243 EP - 249 VL - 43 IS - 2 SN - 0004-3591, 0004-3591 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Environmental Exposure -- adverse effects KW - Rheumatic Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70928836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Approaches+for+identifying+and+defining+environmentally+associated+rheumatic+disorders.&rft.au=Miller%2C+F+W%3BHess%2C+E+V%3BClauw%2C+D+J%3BHertzman%2C+P+A%3BPincus%2C+T%3BSilver%2C+R+M%3BMayes%2C+M+D%3BVarga%2C+J%3BMedsger%2C+T+A%3BLove%2C+L+A&rft.aulast=Miller&rft.aufirst=F&rft.date=2000-02-01&rft.volume=43&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-09 N1 - Date created - 2000-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis. AN - 70915892; 10676641 AB - It is not known whether transcriptional suppression by de novo methylation occurs within the promoter region of the p53 gene during multistage tumorigenesis. To address this question, in vivo alterations in the CpG methylation within the rat p53 promoter region were evaluated in control, preneoplastic, and tumor tissue during tumor progression using the folate/methyl-deficient model of hepatocarcinogenesis. Alterations in CpG methylation were found to be site-specific and to vary depending on the stage of carcinogenesis. To further explore the effect of site-specific methylation on p53 promoter activity, reporter gene constructs were prepared containing specifically methylated sites within the p53 promoter region, and the transcriptional activity in cultured mammalian cells was determined in a transient transfection assay. Relative to the unmethylated construct as a positive control, single-site methylation at nucleotide (nt) -450, which occurs 216 nt upstream from the 85-nt minimal promoter region, suppressed promoter activity by 85%. In contrast, single-site methylation at nt -179, which occurs within the minimal essential promoter region, suppressed activity by only 20%. The p53 promoter constructs containing the singly methylated CpG site at nt -450 were then reevaluated for processive changes in methylation status 48 h after transfection, during maximum suppression of promoter activity. Restriction analysis with methylation-sensitive enzymes revealed that de novo methylation had occurred after transfection at previously unmethylated sites. These findings suggest that nt -450 may constitute a critical site for initiation of de novo methylation and processive spreading of methylation associated with transcriptional inactivation of the p53 gene. Furthermore, the results suggest a possible alternative mechanism for the silencing of the p53 gene in tumors that do not have p53 mutations. JF - Cancer research AU - Pogribny, I P AU - Pogribna, M AU - Christman, J K AU - James, S J AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2000/02/01/ PY - 2000 DA - 2000 Feb 01 SP - 588 EP - 594 VL - 60 IS - 3 SN - 0008-5472, 0008-5472 KW - Dinucleoside Phosphates KW - 0 KW - cytidylyl-3'-5'-guanosine KW - 2382-65-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Genes, Reporter KW - CHO Cells KW - Male KW - Cricetinae KW - Promoter Regions, Genetic KW - Genes, p53 KW - DNA Methylation KW - Gene Expression Regulation KW - Dinucleoside Phosphates -- metabolism KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70915892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Single-site+methylation+within+the+p53+promoter+region+reduces+gene+expression+in+a+reporter+gene+construct%3A+possible+in+vivo+relevance+during+tumorigenesis.&rft.au=Pogribny%2C+I+P%3BPogribna%2C+M%3BChristman%2C+J+K%3BJames%2C+S+J&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2000-02-01&rft.volume=60&rft.issue=3&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-28 N1 - Date created - 2000-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incidence and characterization of Listeria monocytogenes from domestic and imported foods in Korea. AN - 70911554; 10678422 AB - A total of 1,537 domestic and imported food products were examined for the incidence of Listeria monocytogenes between 1993 and 1997 in Korea. L. monocytogenes was detected using the U.S. Department of Agriculture isolation method. Isolated L. monocytogenes was confirmed by polymerase chain reaction with hly1 and hly2 primers designed from the listeriolysin O. Overall, 122 samples (7.9%) contained L. monocytogenes. The rate of isolation was 4.3% for beef, 19.1% for pork, 30.2% for chicken, 1.2% for shellfish, 4.4% for raw milk, 4.4% for frozen smoked mussels, and 6.1% for ice cream. No L. monocytogenes was found in pasteurized milk, pasteurized processed cheese, saltwater fish, dried seafoods, or ham. The overall incidence was lower than that reported in previous studies from other countries. Most isolates were serotype 1/2b except for chicken, in which serotype 1/2a was predominant. The serotyping results might imply the presence of food or geography-specific L. monocytogenes strains. JF - Journal of food protection AU - Baek, S Y AU - Lim, S Y AU - Lee, D H AU - Min, K H AU - Kim, C M AD - Division of Food Microbiology, Korea Food and Drug Administration, Seoul. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 186 EP - 189 VL - 63 IS - 2 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Animals KW - Serotyping KW - Korea KW - Listeria monocytogenes -- isolation & purification KW - Food Microbiology KW - Listeria monocytogenes -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70911554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Incidence+and+characterization+of+Listeria+monocytogenes+from+domestic+and+imported+foods+in+Korea.&rft.au=Baek%2C+S+Y%3BLim%2C+S+Y%3BLee%2C+D+H%3BMin%2C+K+H%3BKim%2C+C+M&rft.aulast=Baek&rft.aufirst=S&rft.date=2000-02-01&rft.volume=63&rft.issue=2&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-02 N1 - Date created - 2000-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protecting workers with developmental disabilities. AN - 70909553; 10675973 JF - Applied occupational and environmental hygiene AU - Lenhart, S W AD - NIOSH Health Hazard Evaluation Program, Cincinnati, Ohio 45226-1998, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 171 EP - 181 VL - 15 IS - 2 SN - 1047-322X, 1047-322X KW - Index Medicus KW - United States KW - Policy Making KW - Occupational Exposure -- prevention & control KW - Humans KW - Wounds and Injuries -- prevention & control KW - Organizational Case Studies KW - National Institute for Occupational Safety and Health (U.S.) KW - Developmental Disabilities KW - Occupational Health KW - Disabled Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70909553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Protecting+workers+with+developmental+disabilities.&rft.au=Lenhart%2C+S+W&rft.aulast=Lenhart&rft.aufirst=S&rft.date=2000-02-01&rft.volume=15&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-08 N1 - Date created - 2000-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of acute nicotine on several operant behaviors in rats. AN - 70903193; 10672976 AB - The present experiment assessed nicotine's effects on complex cognitive processes using a variety of operant tasks in rats, including incremental repeated acquisition (IRA) to assess learning; conditioned position responding (CPR) to assess auditory, visual, and position discrimination; progressive ratio (PR) to assess motivation; temporal response differentiation (TRD) to assess timing; and differential reinforcement of low response rates (DRL) to assess timing and response inhibition. Acute nicotine administration (0.0, 0.3, 0.42, 0.56, 0.75, and 1.0 mg/kg, IP) increased IRA and CPR response rate without significantly altering accuracy. Nicotine had similar effects on response rate for PR. For TRD, nicotine had a U-shaped dose effect on accuracy, but failed to shift the mode of the TRD response distribution. For DRL, nicotine reduced accuracy and also shifted the mode of the DRL response initiation time distribution to the left. Nicotine produced an inverted U-shaped dose-effect curve for the overall number of "bursting" responses under both of these schedules. The results of this experiment suggest that nicotine can impair performance on some aspects of cognitive-behavioral performance, while simultaneously improving performance on others. JF - Pharmacology, biochemistry, and behavior AU - Popke, E J AU - Mayorga, A J AU - Fogle, C M AU - Paule, M G AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079-9502, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 247 EP - 254 VL - 65 IS - 2 SN - 0091-3057, 0091-3057 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Cognition -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Reaction Time -- drug effects KW - Nicotine -- pharmacology KW - Learning -- drug effects KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70903193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Effects+of+acute+nicotine+on+several+operant+behaviors+in+rats.&rft.au=Popke%2C+E+J%3BMayorga%2C+A+J%3BFogle%2C+C+M%3BPaule%2C+M+G&rft.aulast=Popke&rft.aufirst=E&rft.date=2000-02-01&rft.volume=65&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-14 N1 - Date created - 2000-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA adduct formation and molecular analysis of in vivo lacI mutations in the mammary tissue of Big Blue rats treated with 7, 12-dimethylbenz[a]anthracene. AN - 70901762; 10657967 AB - Recently we compared the lacI and Hprt mutant frequencies (MFs) and types of mutations in lymphocytes of Big Blue((R)) (BB) rats exposed to 7,12-dimethylbenz[a]anthracene (DMBA) under conditions that result in mammary gland tumors. In this study, we have examined the target mammary tissue for DMBA-induced DNA adducts, lacI MF and types of lacI mutations. Seven-week-old female BB rats were given single doses of 0, 20 or 130 mg/kg DMBA by gavage and the DNA adducts and lacI MFs in the mammary tissue were measured over a period of 14 days and 18 weeks, respectively, following treatment. The lacI MF in the mammary tissue increased for 10 weeks and then remained relatively constant; 130 mg/kg DMBA produced a 14-fold increase in the MF (255 +/- 50 x 10(-6) p.f.u.) over control MF (18. 3 +/- 4 x 10(-6) p.f.u.). (32)P-post-labeling analysis of DNA from mammary tissue and splenic lymphocytes of treated rats revealed two major adducts. Comparison of these adducts with DMBA standards indicated that the adducts formed by DMBA involved both G:C and A:T base pairs. DNA sequencing revealed that the majority of DMBA-induced lacI mutations were base pair substitutions and that A:T-->T:A (44% of the independent mutations) and G:C-->T:A (24% of the independent mutations) transversions were the predominant types. Furthermore, the mutational results revealed a 'hotspot' for a G-->T mutation in codon 95 (GTG-->TTG) of the lacI gene in mammary tissue. These results suggest that DMBA is highly mutagenic to lacI in mammary tissue and that adducts with both G:C and A:T base pairs participate in forming mutations in DMBA-treated BB rats. JF - Carcinogenesis AU - Manjanatha, M G AU - Shelton, S D AU - Culp, S J AU - Blankenship, L R AU - Casciano, D A AD - Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Divisions of Genetic and Biochemical Toxicology, Jefferson, AR 72079, USA. mmanjanatha@nctr.fda.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 265 EP - 273 VL - 21 IS - 2 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Codon KW - DNA Adducts KW - Mutagens KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Index Medicus KW - Rats KW - Frameshift Mutation KW - Lymphocytes -- chemistry KW - Animals KW - Codon -- genetics KW - Spleen -- cytology KW - DNA Mutational Analysis KW - Point Mutation KW - Organ Specificity KW - Animals, Genetically Modified KW - Female KW - Amino Acid Substitution KW - Mammary Neoplasms, Experimental -- chemically induced KW - Mammary Glands, Animal -- drug effects KW - DNA Damage KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Mammary Glands, Animal -- chemistry KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Mammary Neoplasms, Experimental -- genetics KW - Mutation KW - Lac Operon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70901762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=DNA+adduct+formation+and+molecular+analysis+of+in+vivo+lacI+mutations+in+the+mammary+tissue+of+Big+Blue+rats+treated+with+7%2C+12-dimethylbenz%5Ba%5Danthracene.&rft.au=Manjanatha%2C+M+G%3BShelton%2C+S+D%3BCulp%2C+S+J%3BBlankenship%2C+L+R%3BCasciano%2C+D+A&rft.aulast=Manjanatha&rft.aufirst=M&rft.date=2000-02-01&rft.volume=21&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-03 N1 - Date created - 2000-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Direct polymerase chain reaction for detection of toxigenic Corynebacterium diphtheriae strains from the Republic of Georgia after prolonged storage. AN - 70890090; 10657207 AB - A total of 226 paired nose and throat swab specimens from 113 clinical diphtheria cases from the republic of Georgia were analyzed by direct polymerase chain reaction targeting both A and B subunits of the diphtheria toxin gene, tox. Even after prolonged transport and extensive storage (7-14 months) of the clinical specimens in silica gel packages, direct polymerase chain reaction detected the diphtheria tox gene in 54% of the specimens. Specimens obtained by throat swab were three times more likely than those obtained by nose swab to be positive for Corynebacterium diphtheriae. JF - The Journal of infectious diseases AU - Kobaidze, K AU - Popovic, T AU - Nakao, H AU - Quick, L AD - Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA. Y1 - 2000/02// PY - 2000 DA - February 2000 SP - S152 EP - S155 VL - 181 Suppl 1 SN - 0022-1899, 0022-1899 KW - Diphtheria Toxin KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Evaluation Studies as Topic KW - Humans KW - Case-Control Studies KW - Nose -- microbiology KW - Pharynx -- microbiology KW - Georgia (Republic) -- epidemiology KW - Diphtheria Toxin -- biosynthesis KW - Polymerase Chain Reaction -- methods KW - Diphtheria -- diagnosis KW - Specimen Handling KW - Diphtheria -- microbiology KW - Diphtheria -- epidemiology KW - Corynebacterium diphtheriae -- genetics KW - Diphtheria Toxin -- genetics KW - Corynebacterium diphtheriae -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70890090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Direct+polymerase+chain+reaction+for+detection+of+toxigenic+Corynebacterium+diphtheriae+strains+from+the+Republic+of+Georgia+after+prolonged+storage.&rft.au=Kobaidze%2C+K%3BPopovic%2C+T%3BNakao%2C+H%3BQuick%2C+L&rft.aulast=Kobaidze&rft.aufirst=K&rft.date=2000-02-01&rft.volume=181+Suppl+1&rft.issue=&rft.spage=S152&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-13 N1 - Date created - 2000-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Doing what counts for patient safety: federal actions to reduce medical errors and their impact AN - 59903217; 2003-0808630 AB - Examines medical errors in the US, setting strategies for standards in work performance and reporting systems, and working with the private sector and state governments to improve patient safety. In response to the Institute of Medicine's 2000 report, "To err is human: building a safer health system", indexed in PAIS International, 2000. JF - United States Agency for Healthcare Research and Quality, February 2000. Y1 - 2000/02// PY - 2000 DA - February 2000 PB - United States Agency for Healthcare Research and Quality KW - Consumer protection -- United States KW - United States -- Medical sector KW - Medical errors -- United States KW - Medical service -- Safety measures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59903217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Doing+what+counts+for+patient+safety%3A+federal+actions+to+reduce+medical+errors+and+their+impact&rft.title=Doing+what+counts+for+patient+safety%3A+federal+actions+to+reduce+medical+errors+and+their+impact&rft.issn=&rft_id=info:doi/ L2 - http://www.quic.gov/report/errors6.pdf LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Agency Healthcare Research and Quality N1 - Document feature - bibl(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Relation of radon in ground water and air to bedrock geology of New Hampshire AN - 52020769; 2003-017230 JF - Abstracts with Programs - Geological Society of America AU - Moore, Richard B AU - Boudette, Eugene L AU - Chase, David S AU - Anonymous Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 61 PB - Geological Society of America (GSA), Boulder, CO VL - 32 IS - 1 SN - 0016-7592, 0016-7592 KW - United States KW - bedrock KW - pegmatite KW - igneous rocks KW - granites KW - radioactive decay KW - radon KW - environmental analysis KW - drinking water KW - ground water KW - New Hampshire KW - two-mica granite KW - plutonic rocks KW - noble gases KW - metals KW - uranium KW - water wells KW - actinides KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52020769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Relation+of+radon+in+ground+water+and+air+to+bedrock+geology+of+New+Hampshire&rft.au=Moore%2C+Richard+B%3BBoudette%2C+Eugene+L%3BChase%2C+David+S%3BAnonymous&rft.aulast=Moore&rft.aufirst=Richard&rft.date=2000-02-01&rft.volume=32&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Northeastern Section, 35th annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2003-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - actinides; bedrock; drinking water; environmental analysis; granites; ground water; igneous rocks; metals; New Hampshire; noble gases; pegmatite; plutonic rocks; radioactive decay; radon; two-mica granite; United States; uranium; water wells ER - TY - JOUR T1 - Prevention Effectiveness of Rollover Protective Structures--Part III: Economic Analysis AN - 17522307; 4710763 AB - The purpose of this part of the study is to assess the costs and benefits of either installing rollover protective structure (ROPS) on tractors lacking ROPS and for which ROPS are available or replacing the tractors with newer ROPS-equipped ones, relative to doing nothing. The methods used are cost-effectiveness and cost-benefit analyses. The cost-effectiveness analysis shows that compared to the "do nothing" strategy, the "install ROPS" strategy would cost $489,373 per injury averted and the "replace tractor" strategy would cost $14.3 million per injury averted over a 23-year period. The cost-benefit analysis shows that compared to the "do nothing" strategy, the "install ROPS" strategy would save society $1.5 billion while the "replace tractor" strategy would cost society $18.7 billion. While both the "install ROPS" and the "replace tractor" strategies are effective at saving lives and preventing injuries, this study has concluded that the preferred strategy in terms of cost-effectiveness is to "install ROPS" on tractors lacking them and for which ROPS are available. JF - Journal of Agricultural Safety and Health AU - Pana-Cryan, R AU - Myers, M L AD - NIOSH/CDC, 1600 Clifton Rd., NE, MS D-40, Atlanta, GA 30333, USA, rfp2@cdc.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 57 EP - 70 VL - 6 IS - 1 SN - 1074-7583, 1074-7583 KW - farming KW - rollover KW - safety engineering KW - tractors KW - Health & Safety Science Abstracts KW - Agriculture KW - Accidents KW - Motor vehicles KW - Economics KW - Occupational safety KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17522307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Prevention+Effectiveness+of+Rollover+Protective+Structures--Part+III%3A+Economic+Analysis&rft.au=Pana-Cryan%2C+R%3BMyers%2C+M+L&rft.aulast=Pana-Cryan&rft.aufirst=R&rft.date=2000-02-01&rft.volume=6&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; Accidents; Agriculture; Motor vehicles; Economics ER - TY - JOUR T1 - Prevention Effectiveness of Rollover Protective Structures--Part II: Decision Analysis AN - 17521776; 4710762 AB - This is the second of three articles that evaluate the consequences of using rollover protective structures (ROPS) on agricultural tractors. It presents the results of a decision analysis that compares three strategies for preventing injuries when agricultural tractors without ROPS overturn. The three strategies examined are "do nothing", "install ROPS", and "replace tractor". The strategies are implemented over a five-year period and health outcomes expressed as fatal and nonfatal injuries are calculated over a 23-year period. The "do nothing" strategy would result in 1,450 fatalities and 1,806 nonfatal injuries, while the "install ROPS" strategy would prevent 1,176 fatalities and 957 nonfatal injuries, and the "replace tractor" strategy would prevent 1,188 fatalities and 967 nonfatal injuries. The latter two strategies reflect more than an 80% reduction in fatalities and about 53% reduction in nonfatal injuries. The study does not consider overturn injuries that result from tractors lacking ROPS and for which ROPS are unavailable. JF - Journal of Agricultural Safety and Health AU - Myers, M L AU - Pana-Cryan, R AD - NIOSH/CDC, 1600 Clifton Rd., NE, MS D-40, Atlanta, GA 30333, USA, rfp2@cdc.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 41 EP - 55 VL - 6 IS - 1 SN - 1074-7583, 1074-7583 KW - farming KW - rollover KW - tractors KW - Health & Safety Science Abstracts KW - Agriculture KW - Accidents KW - Injuries KW - Motor vehicles KW - Occupational safety KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17521776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Prevention+Effectiveness+of+Rollover+Protective+Structures--Part+II%3A+Decision+Analysis&rft.au=Myers%2C+M+L%3BPana-Cryan%2C+R&rft.aulast=Myers&rft.aufirst=M&rft.date=2000-02-01&rft.volume=6&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Motor vehicles; Occupational safety; Accidents; Injuries; Agriculture ER - TY - JOUR T1 - 50-Hertz Magnetic Field and Calcium Transients in Jurkat Cells: Results of a Research and Public Information Dissemination (RAPID) Program Study AN - 17520470; 4707283 AB - An effect on intracellular calcium continues to be proposed as a biochemical pathway for the mediation of biologic effects of electrical-power-frequency magnetic fields (MF). However, reproducible results among laboratories are difficult to attain and the characteristics of magnetic field effects on intracellular free calcium ([Ca super(2+)] sub(i)) are not well understood. We attempted to repeat the studies of Lindstroem et al. [Intracellular Calcium Oscillations in a T-Cell Line by a Weak 50 Hz Magnetic Field. J Cell Physiol 156:395-398 (1993)] by investigating the effect of a 1.5-G 50-Hz MF on [Ca super(2+)] sub(i) in the Jurkat lymphocyte T-cell line. Changes in [Ca super(2+)] sub(i) were determined using microscopic imaging of fura-2 loaded Jurkat cells on poly-L-lysine-coated glass coverslips. The MF was generated by a single coil constructed with bifilar wire and located in the same plane as the cells. Cells were randomly exposed for 8 min to MF, sham field (SF), or no field (NF) conditions. The exposure condition remained coded until data analysis was complete. Each exposure period was preceded by an 8-min data collection to establish a baseline for [Ca super(2+)] sub(i). After each exposure condition, cells were exposed to anti-CD3 antibody that induced a rapid increase in [Ca super(2+)] sub(i) in responsive cells; this provided a positive control. [Ca super(2+)] sub(i) was analyzed for individual cells as spatially-averaged background-corrected 340/380 nm ratios, and a [Ca super(2+)] sub(i) transient was considered significant for positive deviations from baseline of 3x an estimate of noise in the baseline. Typically, 25-50 cells/field were viewed and approximately 50% had no [Ca super(2+)] sub(i) transients in the baseline period and also responded to positive control. Only cells responding to positive control and lacking changes in [Ca super(2+)] sub(i) during the baseline period were considered qualified for assessment during the exposure period. The incidences of [Ca super(2+)] sub(i) transients during the exposure period for two experiments (40x objective) were 16.5, 14.6, and 14.2% for MF, SF, and NF, respectively, and were not statistically significantly different. Previous studies by Lindstroem et al. [Intracellular Calcium Oscillations in a T-Cell Line after Exposure to Extremely-Low-Frequency Magnetic Fields with Variable Frequencies and Flux Densities. Bioelectromagnetics 16:41-47 (1995)] showed a high response rate (92%) for exposure to 1.5-G 50-Hz MF when individual cells were preselected for investigation. We found no such effect when examining many cells simultaneously in a random and blind fashion. These results do not preclude an effect of MF on [Ca super(2+)] sub(i), but suggest that responsive cells, if they exist, were not identified using the approaches that we used in this study. JF - Environmental Health Perspectives AU - Wey, HE AU - Conover, D P AU - Mathias, P AU - Toraason, M AU - Lotz, W G AD - National Institute for Occupational Safety and Health (NIOSH), MS-C23, 4676 Columbia Parkway, Cincinnati OH 45226 USA, mht1@cdc.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 135 EP - 140 VL - 108 IS - 2 SN - 0091-6765, 0091-6765 KW - Jurkat cells KW - Toxicology Abstracts KW - Magnetic fields KW - Calcium KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17520470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=50-Hertz+Magnetic+Field+and+Calcium+Transients+in+Jurkat+Cells%3A+Results+of+a+Research+and+Public+Information+Dissemination+%28RAPID%29+Program+Study&rft.au=Wey%2C+HE%3BConover%2C+D+P%3BMathias%2C+P%3BToraason%2C+M%3BLotz%2C+W+G&rft.aulast=Wey&rft.aufirst=HE&rft.date=2000-02-01&rft.volume=108&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic fields; Calcium ER - TY - JOUR T1 - Ribotype Analysis of Strain Distribution in Listeria monocytogenes AN - 17511343; 4696977 AB - Changes in the temporal and spital patterns of strain distribution for the foodborne pathogen Listeria monocytogenes were studied by ribotyping using the Qualicon Riboprinter system. Ribotype patterns were obtained by using the restriction enzymes EcoRI and PvuII for 72 isolates of L. monocytogenes recovered from smoked salmon samples over a period of 3 years. Each pattern was classified both by comparison to a pattern library and by comparison among the 72 isolate patterns. Eleven EcoRI-based ribogroups and 16 PvuII groups were identified. Eight of the 11 EcoRI ribogroups were found in isolates obtained over a period of >12 months, and 75% of the EcoRI ribogroups that were found in more than one food sample were distributed nationally. Within the set of isolates, there were 26 instances where more than one isolate was obtained from a single food sample. In 35% of these instances, the co-isolates produced different ribotype patterns, indicating that multiple strains of L. monocytogenes commonly coexist in the same environment. Overall, these data indicate that the population of L. monocytogenes commonly consists of a number of widely dispersed strains with little geographic or temporal stratification. JF - Journal of Food Protection AU - Gendel, S M AU - Ulaszek, J AD - Food and Drug Administration and Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 South Archer, Summit-Argo, Illinois 60501, USA, smg@cfsan.fda.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 179 EP - 185 VL - 53 IS - 2 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Ribotyping KW - Listeria monocytogenes KW - Deoxyribonuclease EcoRI KW - Food KW - Deoxyribonuclease PvuII KW - Sampling KW - Food-borne diseases KW - A 01017:Human foods KW - A 01012:Nucleic acids & metabolites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17511343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Ribotype+Analysis+of+Strain+Distribution+in+Listeria+monocytogenes&rft.au=Gendel%2C+S+M%3BUlaszek%2C+J&rft.aulast=Gendel&rft.aufirst=S&rft.date=2000-02-01&rft.volume=53&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Listeria monocytogenes; Ribotyping; Food-borne diseases; Deoxyribonuclease EcoRI; Deoxyribonuclease PvuII; Food; Sampling ER - TY - JOUR T1 - A Trial to Determine the Risk of Decompression Sickness After a 40 Feet of Sea Water for 200 Minute No-Stop Air Dive AN - 17509197; 4700386 AB - Background: The USN93 probabilistic model of decompression sickness (DCS) predicts a DCS risk of 3.9% after a 40 ft of seawater (fsw) for 200 min no-stop air dive, although little data is available to evaluate the accuracy of this prediction. Based on an analysis of Navy Safety Center data from diving on U.S. Navy standard air decompression tables, the observed incidence of DCS for this type of dive is 0.11%. Knowing the true incidence of the dive is important for deciding whether or not to adopt proposed probability based decompression procedures for U.S. Navy diving. Conclusions: This study demonstrates that the incidence of DCS in a laboratory setting is higher than observed in fleet diving. Use of the 40 fsw for 200 min schedule in a decompression computer is likely to result in DCS incidence 2.5- to 70-fold greater than that observed in U.S. Navy diving using table-based procedures. JF - Aviation, Space and Environmental Medicine AU - Ball, R AU - Parker, E C AD - Food and Drug Administration, CBER, Division of Biostatistics and Epidemiology, HFM-220, 1401 Rockville Pike, Rockville, MD 20852, USA, BallR@cber.fda.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 102 EP - 108 VL - 71 IS - 2 SN - 0095-6562, 0095-6562 KW - decompression sickness KW - diving KW - Risk Abstracts; Health & Safety Science Abstracts KW - Military KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17509197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space+and+Environmental+Medicine&rft.atitle=A+Trial+to+Determine+the+Risk+of+Decompression+Sickness+After+a+40+Feet+of+Sea+Water+for+200+Minute+No-Stop+Air+Dive&rft.au=Ball%2C+R%3BParker%2C+E+C&rft.aulast=Ball&rft.aufirst=R&rft.date=2000-02-01&rft.volume=71&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Occupational exposure ER - TY - JOUR T1 - Effects of acute ethanol on indices of cognitive-behavioral performance in rats AN - 17499156; 4692001 AB - The present experiment examined the effects of ethanol on several complex operant behaviors in rats. Tasks included: temporal response differentiation (TRD) to assess timing behavior; differential reinforcement of low response rates (DRL) to assess timing and response inhibition; incremental repeated acquisition (IRA) to assess learning; conditioned position responding (CPR) to assess auditory, visual, and position discrimination; and progressive ratio (PR) to assess motivation. Ethanol (0.0, 0.5, 1.0, 1.5, 2.0, and 3.0 g/kg via orogastric gavage) reduced accuracy and/or percent task completed for the TRD, DRL, and CPR tasks. For CPR, this reduction was accompanied by a reduction in response rates. Ethanol also reduced response rates on the PR task. There were no effects of ethanol on IRA performance. These data suggest that ethanol can selectively impair performance on cognitive-behavioral tasks and that these effects can occur at doses that do not affect the subjects' ability to respond. JF - Alcohol AU - Popke, E J AU - Allen AU - Paule, M G AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA, epopke@nctr.fda.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 187 EP - 192 VL - 20 IS - 2 SN - 0741-8329, 0741-8329 KW - rats KW - Animal Behavior Abstracts; Toxicology Abstracts KW - Motivation KW - Mental performance KW - Auditory discrimination KW - Behavior KW - Cognitive ability KW - Discrimination learning KW - DRL schedule KW - Visual discrimination KW - Operant response KW - Ethanol KW - Y 25617:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17499156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Effects+of+acute+ethanol+on+indices+of+cognitive-behavioral+performance+in+rats&rft.au=Popke%2C+E+J%3BAllen%3BPaule%2C+M+G&rft.aulast=Popke&rft.aufirst=E&rft.date=2000-02-01&rft.volume=20&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ethanol; Operant response; Discrimination learning; DRL schedule; Motivation; Mental performance; Cognitive ability; Behavior; Visual discrimination; Auditory discrimination ER - TY - JOUR T1 - Barlines AN - 1439631 AB - Mentions the death of Philip Jones, a retired orchestral trumpet player, chairman of the Musician's Benevolent Fund, and principal at the Trinity College of Music, who died at the age of 71. JF - Classical Music AU - Barda, Clive Y1 - 2000/01/29/ PY - 2000 DA - 2000 Jan 29 SP - 9 CY - London, Eng. PB - Rhinegold Publishing Ltd SN - 0961-2696 KW - Music KW - Music History KW - Trumpet Players KW - Music Organizations KW - Music Teachers KW - Music Schools KW - Orchestras KW - Jones, Philip UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aiimpft&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Classical+Music&rft.atitle=Barlines&rft.au=Barda%2C+Clive&rft.aulast=Barda&rft.aufirst=Clive&rft.date=2000-01-29&rft.volume=&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Classical+Music&rft.issn=09612696&rft_id=info:doi/ LA - English DB - Music Periodicals Database N1 - Name - Trinity College of Music (London) N1 - People - Jones, Philip N1 - Last updated - 2014-04-15 N1 - SubjectsTermNotLitGenreText - Jones, Philip ER - TY - JOUR T1 - Does further clean-up reduce the matrix enhancement effect in gas chromatographic analysis of pesticide residues in food? AN - 70924860; 10677079 AB - Sample extracts of apples, peas, green beans, oranges, raspberries, clementines, carrots, and wheat obtained using the Food and Drug Administration (acetone extraction) and Canadian Pest Management Regulatory Agency (acetonitrile extraction) multiresidue methods for pesticides were subjected to clean-up using different solid-phase extraction (SPE) cartridges in an attempt to reduce or eliminate the matrix enhancement effect. The matrix enhancement effect is related to the blocking of active sites on the injector liner by matrix components, thereby increasing signal in the presence of matrix versus standards in solvent in which the pesticides themselves interact with the active sites. Graphitized carbon black (GCB) was often used in combination with various anion-exchange SPE cartridges. The extracts were then spiked with organophosphorus insecticides. These process standards were then compared to standards in acetone of the same concentration using gas chromatography with flame photometric detection or ion trap mass spectrometric detection. Sample matrix enhancement varied from little to no effect for some pesticides (e.g. chlorpyrifos, malathion) to >200% in the case of certain susceptible pesticides. The GCB removed color components but showed little effect in reducing matrix enhancement by itself. The anion-exchange cartridges in combination with GCB or not, substantially reduced the matrix enhancement effect but did not eliminate it. JF - Journal of chromatography. A AU - Schenck, F J AU - Lehotay, S J AD - Food and Drug Administration, Baltimore District Laboratory, MD 21201, USA. Y1 - 2000/01/28/ PY - 2000 DA - 2000 Jan 28 SP - 51 EP - 61 VL - 868 IS - 1 SN - 0021-9673, 0021-9673 KW - Acetonitriles KW - 0 KW - Pesticide Residues KW - Acetone KW - 1364PS73AF KW - acetonitrile KW - Z072SB282N KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Vegetables -- chemistry KW - United States Food and Drug Administration KW - Edible Grain -- chemistry KW - Quality Control KW - Fruit -- chemistry KW - Food Analysis KW - Pesticide Residues -- analysis KW - Pesticide Residues -- chemistry KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70924860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Does+further+clean-up+reduce+the+matrix+enhancement+effect+in+gas+chromatographic+analysis+of+pesticide+residues+in+food%3F&rft.au=Schenck%2C+F+J%3BLehotay%2C+S+J&rft.aulast=Schenck&rft.aufirst=F&rft.date=2000-01-28&rft.volume=868&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-25 N1 - Date created - 2000-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TNF-alpha regulates transforming growth factor-alpha expression in regenerating murine liver and isolated hepatocytes. AN - 70819143; 10623834 AB - TNF-alpha is a pleotropic proinflammatory cytokine that has been implicated as a contributing factor in a number of disease processes, primarily through its ability to induce the expression of inflammatory and cytotoxic mediators. TNF-alpha is also involved in cell growth accompanying the healing process in multiple organ systems and influences liver repair following hepatotoxic damage or regeneration following partial hepatectomy. In this respect, TNF-alpha is a known mitogen for hepatocytes. In this paper we describe a novel role for TNF-alpha in the modulation of expression of TGF-alpha, the latter being a complete hepatocyte mitogen. TNF-alpha directly up-regulates TGF-alpha mRNA by up to 7-fold in isolated mouse hepatocytes, whereas neutralization of TNF-alpha significantly decreased liver mRNA and protein expression of TGF-alpha following chemical-induced hepatotoxicity. That TNF-alpha directly stimulated TGF-alpha was suggested by the inability of either anti-IL-6 Abs or cycloheximide to inhibit TNF-alpha-induced TGF-alpha expression in hepatocytes. However, in the presence of anti-TGF-alpha neutralizing Abs, the mitogenic activity of TNF-alpha is abrogated. Using cells transfected with the TGF-alpha promoter, and an RNA polymerase inhibitor, it was shown that TNF-alpha modulates TGF-alpha expression through both pre- and posttranscriptional events. Taken together, these data suggest that TNF-alpha participates in liver repair and regeneration, in part, by directly inducing the expression of TGF-alpha. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Gallucci, R M AU - Simeonova, P P AU - Toriumi, W AU - Luster, M I AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2000/01/15/ PY - 2000 DA - 2000 Jan 15 SP - 872 EP - 878 VL - 164 IS - 2 SN - 0022-1767, 0022-1767 KW - Interleukin-6 KW - 0 KW - RNA, Messenger KW - Transforming Growth Factor alpha KW - Tumor Necrosis Factor-alpha KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Interleukin-6 -- secretion KW - RNA, Messenger -- drug effects KW - Transcription, Genetic KW - Mice KW - Cell Separation KW - Carbon Tetrachloride -- toxicity KW - RNA, Messenger -- biosynthesis KW - Cell Division -- immunology KW - Cells, Cultured KW - Interleukin-6 -- antagonists & inhibitors KW - Hepatectomy KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Cell Line KW - Female KW - Liver -- cytology KW - Transforming Growth Factor alpha -- genetics KW - Liver -- immunology KW - Liver -- drug effects KW - Tumor Necrosis Factor-alpha -- immunology KW - Transforming Growth Factor alpha -- biosynthesis KW - Liver -- metabolism KW - Tumor Necrosis Factor-alpha -- physiology KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Liver Regeneration -- genetics KW - Liver Regeneration -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70819143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=TNF-alpha+regulates+transforming+growth+factor-alpha+expression+in+regenerating+murine+liver+and+isolated+hepatocytes.&rft.au=Gallucci%2C+R+M%3BSimeonova%2C+P+P%3BToriumi%2C+W%3BLuster%2C+M+I&rft.aulast=Gallucci&rft.aufirst=R&rft.date=2000-01-15&rft.volume=164&rft.issue=2&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-10 N1 - Date created - 2000-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of multidrug-resistant Salmonella typhimurium DT104 by multiplex polymerase chain reaction AN - 17420280; 4640356 AB - Salmonella typhimurium definitive type 104 (DT104) is a virulent pathogen for humans and animals with many strains having multiple drug resistance characteristics. The organism typically carries resistance to ampicillin, chloramphenicol, florfenicol, streptomycin, sulfonamides, and tetracycline (ACSSuT-resistant). A multiplex PCR method was developed to simultaneously amplify four genes, florfenicol (flo sub(st)), virulence (spvC), invasion (invA), and integron (int) from S. typhimurium DT104 (ACSSuT-type). Twenty-two ACSSuT-resistant DT104 isolates in our collection gave 100% positive reactions to this PCR assay by amplifying 584-, 392-, 321- and 265-bp PCR products, using primers specific to the respective target genes. One Salmonella strain DT23, ACSSuT-resistant, phage type 711 failed to amplify the 584-bp fragment, indicating that this method is specific for DT104-type ACSSuT-resistant S. typhimurium strains. One clinical and one bovine ASSuT-resistant strains that were sensitive to chloramphenicol and florfenicol did not yield a 584-bp fragment, indicating the absence of the flo sub(st) gene. This method will be useful for rapid identification of ACSSuT-type DT104 strains from clinical, food and environmental samples. JF - FEMS Microbiology Letters AU - Khan, A A AD - Division of Microbiology, Food and Drug Administration, National Center for Toxicological Research Jefferson, AR USA Y1 - 2000/01/15/ PY - 2000 DA - 2000 Jan 15 SP - 355 EP - 360 PB - Elsevier VL - 182 IS - 2 SN - 0378-1097, 0378-1097 KW - virulence KW - ampicillin KW - chloramphenicol KW - florfenicol KW - flost gene KW - int gene KW - integrons KW - invA gene KW - spvC gene KW - streptomycin KW - sulfonamide KW - sulfonamides KW - tetracyclines KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Multidrug resistance KW - Tetracyclines KW - Salmonella typhimurium KW - N 14610:Occurrence, isolation & assay KW - J 02814:Drug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17420280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Detection+of+multidrug-resistant+Salmonella+typhimurium+DT104+by+multiplex+polymerase+chain+reaction&rft.au=Khan%2C+A+A&rft.aulast=Khan&rft.aufirst=A&rft.date=2000-01-15&rft.volume=182&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1016%2FS0378-1097%2899%2900609-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella typhimurium; Tetracyclines; Multidrug resistance; Virulence DO - http://dx.doi.org/10.1016/S0378-1097(99)00609-6 ER - TY - JOUR T1 - Regulatory science: a special update from the United States Food and Drug Administration. Preclinical issues and status of investigation of botanical drug products in the United States AN - 17585602; 4675264 AB - A recent survey was conducted across the therapeutic divisions within the CDER, U.S. FDA regarding the number of submissions related to botanical drug products over the past ten years. The overall number of botanical submissions as expressed in the parenthesis are as follows: 1990 (1), 1991 (4), 1992 (4), 1993 (5), 1994 (6), 1995 (5), 1996 (13), 1997 (16), 1998 (10). In the total of 64 counted, 50 of them are submitted in original IND and the rest (14) in pre-IND format. The therapeutic categories are focused on dermatological and topical (19), anti AIDS/antiviral (12), oncologic (13), neuropharmacologic (8), endocrine and metabolic (3), urologic (2), tobacco (2), and cardio-renal products (1). The regulatory actions taken on these submissions showed that 68% of them are evaluated as safe to proceed for the human trials, while the rest (32%) of submissions required agency's regulatory guidance. Among the submissions that required further guidance, 81% were deficient in preclinical pharmacology/toxicology information and the rest (19%) lacks information in other areas (chemistry, clinical protocols). Following agency's guidance, 93% of the submissions that were put on hold were allowed to proceed. In summary, a total of 94% of all the botanical INDs submitted to the agency were allowed to proceed without additional animal toxicity studies conducted. In conclusion, this survey indicates that the growing public interest in botanical supplements has prompted more formal evaluation of the efficacy/safety claims of these products. JF - Toxicology Letters AU - Wu, K-M AU - DeGeorge, J G AU - Atrakchi, A AU - Barry, E AU - Bigger, A AU - Chen, C AU - Du, T AU - Freed, L AU - Geyer, H AU - Goheer, A AU - Jacobs, A AU - Jean, D AU - Rhee, H AU - Osterberg, R AD - Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fisher's Lane, Rockville, MD 20852, USA, wuk@cder.fda.gov Y1 - 2000/01/05/ PY - 2000 DA - 2000 Jan 05 SP - 199 EP - 202 VL - 111 IS - 3 SN - 0378-4274, 0378-4274 KW - FDA KW - USA KW - USA, Food and Drug Administration KW - herbal medicines KW - medicinal plants KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Government policies KW - Medicinal plants KW - Herbal medicines KW - Government policy KW - Pharmaceuticals KW - X 24230:Legislation & recommended standards KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17585602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Regulatory+science%3A+a+special+update+from+the+United+States+Food+and+Drug+Administration.+Preclinical+issues+and+status+of+investigation+of+botanical+drug+products+in+the+United+States&rft.au=Wu%2C+K-M%3BDeGeorge%2C+J+G%3BAtrakchi%2C+A%3BBarry%2C+E%3BBigger%2C+A%3BChen%2C+C%3BDu%2C+T%3BFreed%2C+L%3BGeyer%2C+H%3BGoheer%2C+A%3BJacobs%2C+A%3BJean%2C+D%3BRhee%2C+H%3BOsterberg%2C+R&rft.aulast=Wu&rft.aufirst=K-M&rft.date=2000-01-05&rft.volume=111&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2FS0378-4274%2899%2900152-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA; Government policies; Pharmaceuticals; Herbal medicines; Government policy; Medicinal plants DO - http://dx.doi.org/10.1016/S0378-4274(99)00152-6 ER - TY - JOUR T1 - Fluoro-Jade: Novel Fluorochromes for Detecting Toxicant-Induced Neuronal Degeneration AN - 877593598; 13646019 AB - Two anionic fluorescein derivatives can be used for the simple and definitive localization of neuronal degeneration in brain tissue sections. Initial work on the first generation fluorochrome, Fluoro-Jade, demonstrated the utility of this compound for the detection of neuronal degeneration induced by a variety of well-characterized neurotoxicants, including kainic acid, 3-nitropropionic acid, isoniazid, ibogaine, domoic acid, and dizocilpine maleate (MK-801). After validation, the tracer was used to reveal previously unreported sites of neuronal degeneration associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), methamphetamine, and d-fenfluramine. Preliminary findings with a second generation fluorescein derivative, Fluoro-Jade B, suggest that this tracer results in staining of optimal contrast and resolution in animals dosed with kainic acid. These 2 tracers can be combined with other histologic methods, including immunofluoresence and fluorescent Nissl stains. Recent preliminary findings on a number of specialized applications of Fluoro-Jade include the detection of apoptosis, amyloid plaques, astrocytes, and dead cells in tissue culture. JF - Toxicologic Pathology AU - Schmued, Larry C AU - Hopkins, Keri J AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 91 EP - 99 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 28 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Apoptosis KW - Astrocytes KW - Domoic acid KW - MPTP KW - Brain KW - D-Fenfluramine KW - Stains KW - Tissue culture KW - Neurodegeneration KW - MK-801 KW - fluorescein KW - Tracers KW - 3-Nitropropionic acid KW - Kainic acid KW - Methamphetamine KW - Fluorescent indicators KW - Plaques KW - fluorochromes KW - Isoniazid KW - Dizocilpine KW - Amyloid KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877593598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Fluoro-Jade%3A+Novel+Fluorochromes+for+Detecting+Toxicant-Induced+Neuronal+Degeneration&rft.au=Schmued%2C+Larry+C%3BHopkins%2C+Keri+J&rft.aulast=Schmued&rft.aufirst=Larry&rft.date=2000-01-01&rft.volume=28&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F019262330002800111 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Apoptosis; Domoic acid; Astrocytes; MPTP; Brain; D-Fenfluramine; Tissue culture; Stains; Neurodegeneration; MK-801; fluorescein; Tracers; Methamphetamine; Kainic acid; 3-Nitropropionic acid; Fluorescent indicators; Plaques; fluorochromes; Amyloid; Dizocilpine; Isoniazid DO - http://dx.doi.org/10.1177/019262330002800111 ER - TY - JOUR T1 - Virtual Neuropathology: Three-Dimensional Visualization of Lesions Due to Toxic Insult AN - 856755520; 13646020 AB - A first-pass approach incorporating high-field magnetic resonance imaging (MRI) was used for rapid detection of neuropathologic lesions in fixed rat brains. This inherently 3-dimensional and nondestructive technique provides high-resolution, high-contrast images of fixed neuronal tissue in the absence of sectioning or staining. This technique, magnetic resonance microscopy (MRM), was used to identify diverse lesions in 2 well-established rat neurotoxicity models. The intrinsic contrast in the images delineated lesions that were identified using a battery of histologic stains, some of which would not be used in routine screening. Furthermore, the MRM images provided the locations of lesions, which were verified upon subsequent sectioning and staining of the same samples. The inherent contrast generated by water properties is exploited in MRM by choosing suitable pulse sequences, or proton stains. This approach provides the potential for a comprehensive initial MRM screen for neurotoxicity in preclinical models with the capability for extrapolation to clinical analyses using classical MRI. JF - Toxicologic Pathology AU - Lester, David S AU - Pine, PScott AU - Delnomdedieu, Marielle AU - Johannessen, Jan N AU - Johnson, GAllan AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 100 EP - 104 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 28 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Protons KW - Magnetic resonance imaging KW - Neurotoxicity KW - Sectioning KW - Microscopy KW - Brain KW - N.M.R. KW - Stains KW - Neuropathology KW - X 24390:Radioactive Materials KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856755520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Virtual+Neuropathology%3A+Three-Dimensional+Visualization+of+Lesions+Due+to+Toxic+Insult&rft.au=Lester%2C+David+S%3BPine%2C+PScott%3BDelnomdedieu%2C+Marielle%3BJohannessen%2C+Jan+N%3BJohnson%2C+GAllan&rft.aulast=Lester&rft.aufirst=David&rft.date=2000-01-01&rft.volume=28&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F019262330002800112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Protons; Microscopy; Sectioning; Neurotoxicity; Magnetic resonance imaging; Brain; N.M.R.; Stains; Neuropathology DO - http://dx.doi.org/10.1177/019262330002800112 ER - TY - JOUR T1 - Diethylene glycol deaths in Haiti. AN - 72223745; 10968588 JF - Public health reports (Washington, D.C. : 1974) AU - Junod, S W AD - US Food and Drug Administration, Rockville, MD 20857, USA. sjujod@ora.fda.gov PY - 2000 SP - 78 EP - 86 VL - 115 IS - 1 SN - 0033-3549, 0033-3549 KW - Ethylene Glycols KW - 0 KW - diethylene glycol KW - 61BR964293 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Haiti -- epidemiology KW - United States Food and Drug Administration KW - Public Health KW - International Cooperation KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Child, Preschool KW - Acute Kidney Injury -- chemically induced KW - Acute Kidney Injury -- mortality KW - Ethylene Glycols -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72223745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Diethylene+glycol+deaths+in+Haiti.&rft.au=Junod%2C+S+W&rft.aulast=Junod&rft.aufirst=S&rft.date=2000-01-01&rft.volume=115&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-21 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMJ. 1995 Jul 8;311(6997):88-91 [7613408] JAMA. 1998 Apr 15;279(15):1175-80 [9555756] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety. AN - 71776821; 10944812 JF - Springer seminars in immunopathology AU - Klinman, D M AU - Kamstrup, S AU - Verthelyi, D AU - Gursel, I AU - Ishii, K J AU - Takeshita, F AU - Gursel, M AD - Section of Retroviral Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 173 EP - 183 VL - 22 IS - 1-2 SN - 0344-4325, 0344-4325 KW - Adjuvants, Immunologic KW - 0 KW - Bacterial Vaccines KW - Cytokines KW - DNA, Bacterial KW - Immunoglobulin M KW - Lipopolysaccharides KW - Oligodeoxyribonucleotides KW - Vaccines, DNA KW - Vaccines, Synthetic KW - Galactosamine KW - 7535-00-4 KW - Index Medicus KW - Vaccines, Synthetic -- toxicity KW - Animals KW - Vaccines, DNA -- immunology KW - Vaccines, DNA -- toxicity KW - Humans KW - Safety KW - Listeriosis -- prevention & control KW - Oligodeoxyribonucleotides -- pharmacology KW - Clinical Trials as Topic KW - Oligodeoxyribonucleotides -- chemical synthesis KW - Mice KW - Mice, Inbred BALB C KW - Bacterial Vaccines -- immunology KW - Tularemia -- prevention & control KW - Galactosamine -- toxicity KW - Bacterial Vaccines -- toxicity KW - Vaccines, Synthetic -- immunology KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Oligodeoxyribonucleotides -- immunology KW - Lipopolysaccharides -- toxicity KW - Infection Control KW - Drug Evaluation, Preclinical KW - Antibody Formation -- drug effects KW - Francisella tularensis -- immunology KW - Listeria monocytogenes -- immunology KW - DNA, Bacterial -- toxicity KW - DNA, Bacterial -- immunology KW - Adjuvants, Immunologic -- toxicity KW - Immunity, Innate -- immunology KW - DNA, Bacterial -- pharmacology KW - Cytokines -- biosynthesis KW - CpG Islands -- immunology KW - Immunoglobulin M -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71776821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Springer+seminars+in+immunopathology&rft.atitle=Activation+of+the+innate+immune+system+by+CpG+oligodeoxynucleotides%3A+immunoprotective+activity+and+safety.&rft.au=Klinman%2C+D+M%3BKamstrup%2C+S%3BVerthelyi%2C+D%3BGursel%2C+I%3BIshii%2C+K+J%3BTakeshita%2C+F%3BGursel%2C+M&rft.aulast=Klinman&rft.aufirst=D&rft.date=2000-01-01&rft.volume=22&rft.issue=1-2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Springer+seminars+in+immunopathology&rft.issn=03444325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric detection of bacterial biomarker proteins isolated from contaminated water, lettuce and cotton cloth. AN - 71135978; 10825256 AB - Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra of bacterial proteins were obtained from water, lettuce and cloth samples contaminated with Shigella flexneri, Escherichia coli, and Aeromonas hydrophila. Spectra were obtained using proteins directly isolated from water (or water used for rinsing samples) without culturing the bacteria. For S. flexneri and E. coli, two marker ions for specific proteins associated with a virulence-related property (acid resistance) were easily detected. For A. hydrophila, ions from two specifically selected marker proteins, as well as ions from the larger group of proteins isolated from pure cultures, all matched spectra from a contaminated water sample, providing strong evidence that A. hydrophila was the bacterial contaminant. Rinse water from contaminated lettuce and cloth samples showed the same marker ions as the contaminated water samples. Copyright 2000 John Wiley & Sons, Ltd. JF - Rapid communications in mass spectrometry : RCM AU - Holland, R D AU - Rafii, F AU - Heinze, T M AU - Sutherland, J B AU - Voorhees, K J AU - Lay, J O AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 911 EP - 917 VL - 14 IS - 10 SN - 0951-4198, 0951-4198 KW - Bacterial Proteins KW - 0 KW - Biomarkers KW - Ions KW - Index Medicus KW - Escherichia coli -- isolation & purification KW - Shigella flexneri -- isolation & purification KW - Biomarkers -- analysis KW - Aeromonas hydrophila -- isolation & purification KW - Lasers KW - Lettuce -- microbiology KW - Food Microbiology KW - Bacterial Proteins -- analysis KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - Water Microbiology KW - Gossypium -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71135978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometric+detection+of+bacterial+biomarker+proteins+isolated+from+contaminated+water%2C+lettuce+and+cotton+cloth.&rft.au=Holland%2C+R+D%3BRafii%2C+F%3BHeinze%2C+T+M%3BSutherland%2C+J+B%3BVoorhees%2C+K+J%3BLay%2C+J+O&rft.aulast=Holland&rft.aufirst=R&rft.date=2000-01-01&rft.volume=14&rft.issue=10&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-08 N1 - Date created - 2000-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - On-line sample preparation using restricted-access media in the analysis of the soy isoflavones, genistein and daidzein, in rat serum using liquid chromatography electrospray mass spectrometry. AN - 71069087; 10786906 AB - Soy isoflavones are the subject of many investigations in experimental animals and humans regarding possible modulation of endocrine activity and chemoprevention of carcinogenesis. Genistein and daidzein, the principal biologically active isoflavones in soy, were measured using on-line solid-phase extraction (SPE) and liquid chromatography electrospray mass spectrometry (LC/ES-MS) detection in serum of rats consuming a common open-formula (NIH 31) chow that contained approximately 30 microg each of genistein and daidzein per gram of feed and a specially designed 'soy-free' chow that contained approximately 60-fold lower isoflavones. The use of a restricted-access/reverse phase trap cartridge and automated column switching permitted rapid and robust analytical performance with many injections of plasma onto a reverse phase LC column. Enzymatic deconjugation and a single centrifugation step were the only sample preparation steps required. The limit of detection for the isoflavones, based on the MS responses observed in serum from male and female rats consuming the soy-free chow, was 0.020 microM. The method, which uses deuterated isoflavones as internal standards, was determined to be accurate using spiked control serum (102-110% of added amounts) and precise using spiked control serum and incurred serum (<6% relative standard deviation). The average genistein and daidzein levels were determined in female (0.62 and 0.25 microM, respectively) and male rats (0.35 and 0.20 microM, respectively) consuming the standard diet. The sex difference observed for serum genistein concentrations was statistically significant (p < 0.0001). These results underscore the potential impact of standard open-formula diets on the results from rodent bioassays of biological activity. JF - Rapid communications in mass spectrometry : RCM AU - Doerge, D R AU - Churchwell, M I AU - Delclos, K B AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ddoerge@nctr.fda.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 673 EP - 678 VL - 14 IS - 8 SN - 0951-4198, 0951-4198 KW - Estrogens, Non-Steroidal KW - 0 KW - Isoflavones KW - daidzein KW - 6287WC5J2L KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Rats KW - Mass Spectrometry KW - Animals KW - Rats, Sprague-Dawley KW - Reproducibility of Results KW - Chromatography, Liquid KW - Diet KW - Male KW - Female KW - Genistein -- blood KW - Soybeans -- chemistry KW - Estrogens, Non-Steroidal -- blood KW - Isoflavones -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71069087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=On-line+sample+preparation+using+restricted-access+media+in+the+analysis+of+the+soy+isoflavones%2C+genistein+and+daidzein%2C+in+rat+serum+using+liquid+chromatography+electrospray+mass+spectrometry.&rft.au=Doerge%2C+D+R%3BChurchwell%2C+M+I%3BDelclos%2C+K+B&rft.aulast=Doerge&rft.aufirst=D&rft.date=2000-01-01&rft.volume=14&rft.issue=8&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-25 N1 - Date created - 2000-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smoking cessation clinical practice guideline update and Agency for Healthcare Research and Quality tobacco resources. AN - 70924927; 10688950 JF - Tobacco control AU - Murray, E W AD - Agency for Healthcare Research and Quality, 6010 Executive Blvd, Suite 300, Rockville, MD 20852, USA. emurray@ahrq.gov Y1 - 2000 PY - 2000 DA - 2000 SP - I72 EP - I73 VL - 9 Suppl 1 SN - 0964-4563, 0964-4563 KW - Index Medicus KW - United States KW - Humans KW - Health Policy KW - Health Services KW - Smoking Cessation KW - Tobacco Use Disorder -- prevention & control KW - Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70924927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Smoking+cessation+clinical+practice+guideline+update+and+Agency+for+Healthcare+Research+and+Quality+tobacco+resources.&rft.au=Murray%2C+E+W&rft.aulast=Murray&rft.aufirst=E&rft.date=2000-01-01&rft.volume=9+Suppl+1&rft.issue=&rft.spage=I72&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=09644563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-19 N1 - Date created - 2000-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxicity of liquid disinfectants. AN - 70534012; 12594904 AB - This study was prompted by toxic responses to disinfecting agents reported in patients after surgical procedures and in sensitized health care personnel. We evaluated the cytotoxicity of seven substances used in the formulation of common liquid chemical disinfectants and sterilants. We found that a standard method based on direct microscopic examination of cell cultures was insensitive and may result in an underestimation of the risk that disinfectants pose to health care personnel or patients who are exposed to these substances. Using independent quantitative tests measuring the integrity of the cellular membrane, metabolic activity, or cell growth, we found that there is a several-hundredfold difference in the relative toxicity of various disinfecting substances. The concentration toxic in 50% of the cell population (TC(50)) that was found for each disinfectant was similar in a variety of cell lines from human, monkey, or mouse origin. Statistical analysis of TC(50)s suggests that liquid disinfecting agents could be classified in three main groups according to their relative toxicity, with: (1) mild (TC(50) > 1 mM, including phenol, hydrogen peroxide, and formaldehyde); (2) moderate (1mM > TC(50) > 0.1 mM, sodium hypochlorite); and (3) severe (TC(50) < 0.1 mM, glutaraldehyde, cupric ascorbate, and peracetic acid) toxicity. These data suggest a vast difference in the potential risk of various disinfectants and sterilants. The data presented in this study should help to define the relative toxic risk of different disinfecting substances to patients and health care personnel and assist in the selection of safer microbicidal formulations. JF - Surgical infections AU - Sagripanti, J L AU - Bonifacino, A AD - Molecular Biology Branch, (HFZ-113), Division of Life Sciences, Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 3 EP - 14 VL - 1 IS - 1 SN - 1096-2964, 1096-2964 KW - Disinfectants KW - 0 KW - Solutions KW - Formaldehyde KW - 1HG84L3525 KW - Phenol KW - 339NCG44TV KW - Copper KW - 789U1901C5 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Sodium Hypochlorite KW - DY38VHM5OD KW - Peracetic Acid KW - I6KPI2E1HD KW - cupric chloride KW - S2QG84156O KW - Glutaral KW - T3C89M417N KW - Index Medicus KW - Animals KW - Cell Line -- drug effects KW - Humans KW - Peracetic Acid -- toxicity KW - Mice KW - Hydrogen Peroxide -- toxicity KW - Phenol -- toxicity KW - Sodium Hypochlorite -- toxicity KW - Cercopithecus aethiops KW - Glutaral -- toxicity KW - Copper -- toxicity KW - Formaldehyde -- toxicity KW - Cell Physiological Phenomena -- drug effects KW - Toxicity Tests -- methods KW - Disinfectants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70534012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgical+infections&rft.atitle=Cytotoxicity+of+liquid+disinfectants.&rft.au=Sagripanti%2C+J+L%3BBonifacino%2C+A&rft.aulast=Sagripanti&rft.aufirst=J&rft.date=2000-01-01&rft.volume=1&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Surgical+infections&rft.issn=10962964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-24 N1 - Date created - 2003-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Substance Abuse Treatment for Persons with Child Abuse and Neglect Issues. Treatment Improvement Protocol (TIP) Series, 36. AN - 62429692; ED440329 AB - This volume of the Treatment Improvement Protocol (TIP) Series examines treatment issues for both adult survivors of child abuse or neglect and adults in treatment who may be abusing or neglecting their own children. Chapters 1 through 3 focus primarily on adult survivors of child abuse and neglect. Chapter 1 defines child abuse and neglect, provides rates of child abuse and neglect both in the general population and among those in substance abuse treatment, and reviews the literature on links between childhood abuse and subsequent substance abuse. Chapter 2 describes screening and assessment tools that can be used to determine whether a client has a history of childhood abuse or neglect. Chapter 3 presents guidelines on treating clients with histories of child abuse or neglect and referring them to mental health care treatment when necessary. Chapter 4 discusses the personal issues counselors may encounter when working with clients with histories of abuse or neglect and offers suggestions for addressing them. In Chapters 5 and 6, the focus shifts to adults in treatment who may be abusing or neglecting their own children. Chapter 5 shows how alcohol and drug counselors can identify whether their clients are at risk of or are currently abusing or neglecting their children. It discusses what alcohol and drug counselors can do to break the cycle of child abuse and neglect, including how to work with child protective service agencies within the child welfare system. Chapter 6 is an overview of the legal issues that counselors should be aware of as mandated reporters. The TIP concludes with an overview in Chapter 7 of continuing and emerging trends that counselors will need to follow in the coming years. (Contains 405 references and 7 appendixes.) (GCP) Y1 - 2000 PY - 2000 DA - 2000 SP - 199 PB - Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 8-1036, Rockville, MD 20857. KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Crisis Intervention KW - Substance Abuse KW - Parent Counseling KW - Guidelines KW - Child Neglect KW - Mental Health Programs KW - Counseling Objectives KW - Child Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62429692?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Child Health USA, 2000. AN - 62338013; ED447921 AB - Intended to inform policymaking in the public and private sectors, this booklet compiles secondary data for 59 health status indicators. The book provides both graphical and textual summaries of data and addresses long-term trends where applicable. Data are presented for the target populations of Title V funding: infants, children, adolescents, children with special health care needs, and women of childbearing age. In addition to health status, the book addresses health services utilization and population characteristics. Following the introduction, which discusses trends and issues in children's health, the booklet has six sections: (1) "Population Characteristics," including children in poverty, maternal age, working mothers, and school dropouts; (2) "Health Status," discussing the health issues related to infants, children, and adolescents; (3) "Health Services and Utilization," including health care financing, vaccination coverage levels, physician visits, service utilization by children with chronic conditions, hospital utilization, and prenatal care; (4) "State-Specific Data," including data tables on infant and neonatal mortality, prenatal care, low birth weight, births to women under 18, Medicaid information, and health insurance; (5) "City Data," focusing on comparisons between cities with populations over 100,000 and national data on infant mortality, low birth weight, and prenatal care; and (6) "Healthy People 2010 Objectives." (Contains 34 references.) (EV) Y1 - 2000 PY - 2000 DA - 2000 SP - 83 PB - U.S. Government Printing Office, Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402-9328. Single copies also available from: National Maternal and Child Health Clearinghouse, 2070 Chain Bridge Road, Suite 450, Vienna, VA 22182-2536; Tel: 703-356-1964. For full text: http://www.mchb.hrsa.gov. KW - Healthy People 2010 KW - Indicators KW - Medicaid KW - Vaccination KW - ERIC, Resources in Education (RIE) KW - Social Indicators KW - Birth Weight KW - Early Parenthood KW - Mortality Rate KW - Mothers KW - Employed Parents KW - Child Health KW - Infant Mortality KW - Prenatal Care KW - Health Care Costs KW - Demography KW - Health Needs KW - Municipalities KW - Poverty KW - Incidence KW - Health Behavior KW - Tables (Data) KW - Adolescents KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62338013?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For 1999 edition, see ED 438 063. N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - United States Health Workforce Personnel Factbook. AN - 62334093; ED449695 AB - This factbook is a compilation of data from secondary sources such as the American Medical Association and the Federal Bureau of Labor Statistics. It includes information on the supply of health personnel in several disciplines, including physicians, physician assistants, podiatrists, dentists, nursing personnel, optometrists, pharmacists, veterinarians, chiropractors, public health personnel, and allied health personnel. It also presents data on the students preparing to enter those disciplines. The factbook also includes the geographic and specialty distributions of selected health personnel and the participation of minorities and women in health professions schools. (Contains 71 tables.) (EV) Y1 - 2000 PY - 2000 DA - 2000 SP - 209 KW - ERIC, Resources in Education (RIE) KW - Demography KW - Medical Students KW - Health Personnel KW - Labor Supply KW - Higher Education KW - Tables (Data) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62334093?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - School-Based Mental Health Services under Medicaid Managed Care: Policy Report. AN - 62332245; ED448371 AB - This document reviews how schools and providers of school-based mental health programs have implemented managed care contracts with Medicaid managed care organizations. Observations were made at three sites (Albuquerque, NM; Baltimore, MD; New London, CT) where school-based mental health services were provided by Medicaid organizations. Following background information, the methodology used to explore policy options is discussed. Four main conclusions can be drawn from the experiences of the three study sites: (1) better understanding of the interrelationship between community-based mental health services and school-based mental health services is needed; (2) lack of on-site support makes implementation difficult; (3) prevention-oriented services are covered in only a few instances; and (4) better coordination is needed between agencies and school-based mental health services. Other models for including school-based services are also reviewed. A discussion is included on financing and reimbursement issues that may affect viability and expansion of services. Consideration is given to alternative ways to maintain and expand services. (JDM) AU - Robinson, Gail K. AU - Barrett, Marihelen AU - Tunkelrott, Traci AU - Kim, John Y1 - 2000 PY - 2000 DA - 2000 SP - 50 PB - Center for Mental Health Services Knowledge Exchange Network; Tel: 800-789-2647 (Toll Free), For full text: http://wwwmentalhealthorg VL - SMA-00-3456 KW - Medicaid KW - ERIC, Resources in Education (RIE) KW - Financial Support KW - Integrated Services KW - Feasibility Studies KW - Government School Relationship KW - Government Role KW - Cooperation KW - School Psychologists KW - Delivery Systems KW - Mental Health Programs KW - Elementary Secondary Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62332245?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Health Care Mentors: A Work-Based Approach to Developing the Health Care Workforce of Tomorrow. [Fourth Edition]. Career Exploration. AN - 62327601; ED450300 AB - Designed as the final step in a carefully articulated work-readiness program, Mentors provides students interested in health care careers with an opportunity to develop superior employability skills, while striking a balance between work and school. The Mentors program links the school community, the student, and host organizations in a mutually respectful program geared toward developing a student's workplace behaviors. Participants receive the benefit of a volunteer mentor, continue to participate in a school-based support program, and whenever possible, receive a salary through a local funding source. The mentor/student match is closely monitored and the student is evaluated at each level of the program. Through the Mentors program students practice skills in nine core areas: academic foundation; oral and written communication; organizational systems; employability skills; legal responsibilities; ethical considerations; safety practices; teamwork and handling conflict; and health maintenance practices. This booklet contains the activities used in the Mentors program. Student handouts are designed for the pre-mentor, on-site mentor, and post-mentor levels. Handouts for worksite mentors, as well as schools and program managers are also included. (MKA) Y1 - 2000 PY - 2000 DA - 2000 SP - 62 PB - GMS Partners, , 1122 Kersey Rd., Silver Spring, MD 20902 ($20). KW - ERIC, Resources in Education (RIE) KW - Community KW - Practitioners KW - Students KW - Health Services KW - Job Skills KW - Career Exploration KW - Supervisors KW - Secondary Education KW - Mentors KW - Medical Services KW - Education Work Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62327601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aeric&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=&rft.atitle=Health+Care+Mentors%3A+A+Work-Based+Approach+to+Developing+the+Health+Care+Workforce+of+Tomorrow.+%5BFourth+Edition%5D.+Career+Exploration.&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ERIC N1 - Availability - Level 3 - Indexed only N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Health Care Insights: A Unique Introduction to the Health Care Industry. [Fourth Edition]. Career Exploration. AN - 62327534; ED450302 AB - The Insights program begins the journey of becoming ready to work by introducing students to the varied career opportunities, skills, and technologies in today's health care industry. Students travel as a class or group to the host site for a series of seminars. While on site, the students and their accompanying teachers meet with professionals who can orient them to the work environment. During the program, participants visit a variety of host sites including area colleges and/or universities where they learn about the demands of higher education, entrance requirements, financial aid possibilities, and other aspects of college life. Within the program, students practice skills in nine core areas: academic foundation; oral and written communication; organizational systems; employability skills; legal responsibilities; ethical considerations; safety practices; teamwork and handling conflict, and health maintenance practices. Insights not only provides an avenue for high school student career exploration, it also serves as a means for keeping participating teachers attuned to the challenges their students face after high school. This booklet outlines the roles and responsibilities of students, hosts, program managers and school staff involved in the program. The student handouts are provided. (MKA) Y1 - 2000 PY - 2000 DA - 2000 SP - 22 PB - GMS Partners, , 1122 Kersy Rd., Silver Spring, MD 20902 ($15). KW - ERIC, Resources in Education (RIE) KW - Community KW - Practitioners KW - Students KW - Teacher Role KW - Health Services KW - Job Skills KW - Higher Education KW - Career Exploration KW - Secondary Education KW - Medical Services KW - Education Work Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62327534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aeric&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=&rft.atitle=Health+Care+Insights%3A+A+Unique+Introduction+to+the+Health+Care+Industry.+%5BFourth+Edition%5D.+Career+Exploration.&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ERIC N1 - Availability - Level 3 - Indexed only N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Healthy People 2010: Understanding and Improving Health. AN - 62325846; ED443794 AB - This publication presents 10-year health objectives for the nation, reflecting the scientific advances that have occurred in the past 20 years in preventive medicine, disease surveillance, vaccine and therapeutic development, and information technology. It incorporates information from a broad cross-section of scientific experts. The publication includes 467 objectives in 28 focus areas. An "Introduction" discusses "The History Behind the Healthy People 2010 Initiative"; "The Way Healthy People 2010 Goals and Objectives Were Developed"; "The Central Goals of Healthy People 2010"; "The Relationship Between Individual and Community Health"; "How Healthy People 2010 Will Improve the Nation's Health"; "The Key Role of Community Partnerships"; "Everyone Can Help Achieve the Healthy People 2010 Objectives"; and "Other Information Is Available about Healthy People 2010." Section 1, "A Systematic Approach to Health Improvement," discusses "Healthy People 2010 Goals,""Objectives,""Determinants of Health Status," and "Health Status." Section 2, "Leading Health Indicators," focuses on "Physical Activity"; "Overweight and Obesity"; "Tobacco Use"; "Substance Abuse"; "Responsible Sexual Behavior"; "Mental Health"; "Injury and Violence"; "Environmental Quality"; "Immunization"; and "Access to Health Care." A bibliography includes related references. An appendix presents short titles for Healthy People 2010 Objectives. (SM) Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 73 PB - U.S. Government Printing Office, Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402-9328; SN - 0160502608 KW - Vaccination KW - ERIC, Resources in Education (RIE) KW - Obesity KW - Substance Abuse KW - Injuries KW - Physical Fitness KW - Mental Health KW - Violence KW - Health Promotion KW - Disease Control KW - Sexuality KW - Physical Activities KW - Environmental Influences KW - Tobacco KW - Access to Health Care KW - Physical Activity Level UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62325846?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Understanding Title V of the Social Security Act: A Guide to the Provisions of the Federal Maternal and Child Health Block Grant. AN - 62323796; ED450923 AB - The Maternal and Child Health (MCH) Services Block Grant (Title V of the Social Security Act) has operated as a federal-state partnership since the Social Security Act was passed in 1935. Through Title V, the federal government pledged its support of state efforts to extend health and welfare services for mothers and children. Title V has been frequently amended in ensuing years to reflect changing national approaches to maternal and child health and welfare issues. This booklet provides an overview of Title V for those new to the Block Grant program and a compact guide for those familiar with Title V programs. For each portion of the law, a short synopsis is provided and relevant criteria explained. In addition, citations for the pertinent sections of Title V are included so that those interested in more detailed information can refer to the Title itself. (EV) Y1 - 2000 PY - 2000 DA - 2000 SP - 25 PB - Maternal and Child Health Bureau, Parklawn Building, Room 18-05, 5600 Fishers Lane, Rockville, MD 20857; KW - Family Support KW - Social Security Act Title V KW - ERIC, Resources in Education (RIE) KW - Financial Support KW - Federal Legislation KW - Family Financial Resources KW - Mothers KW - Public Policy KW - Federal State Relationship KW - Children KW - State Federal Aid KW - Block Grants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62323796?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - The Outreach Sourcebook, Volume 5: Rural Health Demonstration Projects, 1995 to 1998. AN - 62323125; ED451000 AB - In 1995, the federal Office of Rural Health Policy awarded 3-year outreach demonstration grants to 25 projects to provide direct primary and preventive health care services to rural residents in 20 states. The grant program allows recipients to test innovative ideas against persistent problems of rural health care, such as provider shortages, fragmented delivery systems, and geographic isolation. Recipients must form a consortium of three or more local institutions or agencies to work together toward project goals. Overall, the projects addressed a broad range of rural health care needs. Over half focused on specific needs of mothers, infants, children, and adolescents. Rural minorities, including Hispanics, African Americans, and Native Americans, were the primary beneficiaries in nine projects, and eight projects addressed the needs of the elderly. Seven projects focused their activities in rural schools, which are convenient and effective sites for rural service delivery. Almost every project provided some type of health promotion/education programming for the public, and over half provided continuing education opportunities to health professionals. Three noteworthy programs developed a Nevada statewide network of community health nurses to provide health education to rural students and adults; taught cardiopulmonary resuscitation (CPR) to 10 percent of the population in the project's rural New York service area; and developed a one-stop referral system improving access to care for Grand Junction, Colorado, children aged birth to 18. Short descriptions of the 25 projects summarize activities and include innovative features, obstacles encountered, reasons for success, and contact information. (Contains title and subject indexes.) (SV) AU - Randall, Teri Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 91 PB - Full text at Web site: http://ftp, hrsagov/ftp/ruralhealth/orhpvol5pdf KW - ERIC, Resources in Education (RIE) KW - Program Descriptions KW - Health Programs KW - Outreach Programs KW - Consortia KW - Federal Aid KW - Health Education KW - Rural Areas KW - Professional Continuing Education KW - Medical Education KW - Health Promotion KW - School Health Services KW - Health Services KW - Demonstration Programs KW - Access to Health Care KW - Community Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62323125?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Healthy People 2010: Conference Edition, Volume I [and] Volume II. AN - 62319227; ED443795 AB - This document contains the two volumes of the Conference Edition of Healthy People 2010, a comprehensive, nationwide health promotion and disease prevention agenda. The first section of Volume I, "Healthy People 2010: Understanding and Improving Health," includes "Introduction,""Leading Health Indicators," and "Bibliography. The second section, "Healthy People 2010: Objectives for Improving Health (Part A)," includes a readers guide and the first 15 of 28 focus areas: "Access to Quality Health Services"; "Arthritis, Osteoporosis, and Chronic Back Conditions"; "Cancer"; "Chronic Kidney Disease"; "Diabetes"; "Disability and Secondary Conditions"; "Educational and Community-Based Programs"; "Environmental Health"; "Family Planning"; "Food Safety"; "Health Communication"; "Heart Disease and Stroke"; "HIV"; "Immunization and Infectious Diseases"; and "Injury and Violence Prevention." The first section, "Healthy People 2010: Objectives for Improving Health (Part A)" of Volume II includes: "Maternal, Infant, and Child Health"; "Medical Product Safety"; "Mental Health and Mental Disorders"; "Nutrition and Overweight"; "Occupational Safety and Health"; "Oral Health"; "Physical Activity and Fitness"; "Public Health Infrastructure"; "Respiratory Diseases"; "Sexually Transmitted Diseases"; "Substance Abuse"; "Tobacco Use"; and "Vision and Hearing." The second section of Volume II, "Tracking Healthy People 2010," includes: "General Data Issues" and "Major Data Sources for Healthy People 2010." (SM) Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 1196 PB - U.S. Government Printing Office, Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402-9328; Tel: 800-367-4725; Web site: . KW - Arthritis KW - Back (Human Anatomy) KW - Food Preparation KW - Kidney Disease KW - Vaccination KW - ERIC, Resources in Education (RIE) KW - Obesity KW - Substance Abuse KW - Injuries KW - Physical Fitness KW - Acquired Immune Deficiency Syndrome KW - Mental Health KW - Violence KW - Cancer KW - Health Promotion KW - Disease Control KW - Diabetes KW - Sexuality KW - School Health Services KW - Physical Activities KW - Heart Disorders KW - Environmental Influences KW - Disabilities KW - Tobacco KW - Access to Health Care KW - Family Planning KW - Community Health Services KW - Physical Activity Level UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62319227?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Volume I includes: Understanding and Improving Hea N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Substance Abuse Treatment for Persons with HIV/AIDS. Treatment Improvement Protocol (TIP) Series 37. AN - 62319085; ED443043 AB - The role of substance abuse in the transmission of HIV and AIDS is clear, and the current trend in the pandemic shows that a disproportionate number of minorities in inner cities are affected or are at risk for contracting HIV. The recommendations and guidelines in this TIP support the creation of a comprehensive, integrated system of care for HIV-infected substance abusers. Challenges facing this approach include bringing together disciplines that traditionally work independently. Providers should identify other programs and agencies with which to network in order to provide care for their clients. Providers must work to develop culturally competent systems of care. This involves making services accessible to and highly usable by the target risk populations. Effective systems will recognize the importance of culture, cross-cultural relationships, cultural differences, and the ability to meet culturally unique needs. Counselors working with HIV-infected substance abusers should also be aware of the variety of both HIV- and substance-induced psychiatric symptoms. It is important to recognize the number of sources from which these symptoms can stem. Treatment programs that do not have the resources to adequately assess and treat mental illness should be closely linked to mental health services to which clients can be referred. Ethical and legal issues are also discussed, as well as funding and policy considerations. (Contains 11 appendixes, approximately 500 resources, and 49 figures.) (JDM) Y1 - 2000 PY - 2000 DA - 2000 SP - 335 PB - Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 8-1036, Rockville, MD 20857. KW - Comorbidity KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Communicable Diseases KW - Substance Abuse KW - Cultural Awareness KW - Counselor Training KW - Behavior Modification KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Cultural Differences KW - Public Policy KW - Drug Rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62319085?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For other documents in the TIP Series see CG 030 0 N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Mind over Matter: The Brain's Response to Drugs. Teacher's Guide. Revision. AN - 62318600; ED447127 AB - This teacher's guide is for the "Mind Over Matter" series, a neuroscience education series designed to encourage students in grades 5-9 to learn about the biological effects of drug abuse on the body and the brain. "Mind Over Matter" includes eight colorful, glossy magazines, each of which is devoted to a specific drug or drug group (stimulants, hallucinogens, inhalants, marijuana, opiates, nicotine, methamphetamine, and steroids). Each of the magazines describes the effects of specific drugs or drug types on the anatomy and physiology of the brain and the body. These educational materials also highlight ways in which these drug-induced changes affect both behaviors and emotions. The background information and lesson plans contained in this guide, when used in combination with the magazines in the series, will promote an understanding of the physical reality of drug use, as well as curiosity about neuroscience. The guide presents background information on brain anatomy, nerve cells and neurotransmission, and the effects of drug abuse on the brain. It also suggests a brain anatomy educational activity that can be used throughout the curriculum as well as additional activities for each of the eight drug topics. Appendixes offer resources, a reading list, and reproducibles. (SM) Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 61 PB - U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Office of Science Policy and Communications, Science Policy Branch, 6001 Executive Boulevard, Room 5230 MSC 9591, Bethesda, MD 20892; KW - Amphetamines KW - Brain Functions KW - Neurosciences KW - Nicotine KW - Steroids KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Teachers KW - Inhalants KW - Comprehensive School Health Education KW - Brain KW - Elementary Secondary Education KW - Stimulants KW - Narcotics KW - Marijuana KW - Illegal Drug Use KW - Biological Sciences KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62318600?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - FDA Procedures for Standardization and Certification of Retail Food Inspection/Training Officers, 2000. AN - 62310211; ED451402 AB - This document provides information, standards, and behavioral objectives for standardization and certification of retail food inspection personnel in the Food and Drug Administration (FDA). The procedures described in the document are based on the FDA Food Code, updated to reflect current Food Code provisions and to include a more refined focus on foodborne illness risk factors, Food Code interventions, and applications of the principles of Hazard Analysis Critical Control Point (HACCP). The document is organized in four chapters. The first chapter explains the rationale for the standards and the procedures guide, the scope of the guide, and definitions. Chapter 2 describes the qualifications required for certification as a retail food inspection and training officer, and Chapter 3 describes the field requirements for certification. Chapter 4 describes the communication skills required to convey the purpose and the findings of the inspection. Two tables, five annexes, and seven charts list all the regulations that candidates for certification must know, how the regulations are applied, and how the candidates must demonstrate their knowledge. (KC) Y1 - 2000 PY - 2000 DA - 2000 SP - 114 KW - Food and Drug Administration KW - Food Safety KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Food Handling Facilities KW - Competence KW - Food Standards KW - Communication Skills KW - Foods Instruction KW - Risk Management KW - Federal Regulation KW - Behavioral Objectives KW - Student Evaluation KW - Certification KW - Food and Drug Inspectors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62310211?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - The Allied Health Professions: Opportunities for Minority Students. Career Guidebook. AN - 62250414; ED463421 AB - The term "allied health" refers to a cluster of health professions encompassing as many as 200 occupational titles (exclusive of physicians and nurses) involved with the delivery of health or related services pertaining to the identification, evaluation, prevention, and treatment of diseases and disorders; dietary and nutritional services; and rehabilitation and health systems management, among others. This guidebook was developed to encourage minority students to pursue allied health careers and to provide information to those considering such careers. The guide covers definitions of allied health occupations, the need for minority groups in allied health professions, and steps in preparing for a career in allied health. It also describes 23 of the allied health professions and the educational requirements for each. The guide provides lists of 23 allied health professional associations, and colleges and universities serving minority students and offering allied health professions programs (73 serving Asian-Americans, 199 serving Hispanic students, 94 historically or predominantly black colleges and universities, and 31 tribal colleges and universities). The guide lists 80 sources of scholarships, federal government financial aid programs, and resources and internships serving African-American, Native American, and Hispanic students. (Contains 15 references.) (KC) AU - Castro, Maria Y1 - 2000 PY - 2000 DA - 2000 SP - 70 KW - African Americans KW - ERIC, Resources in Education (RIE) KW - Students KW - Postsecondary Education KW - Black Colleges KW - Career Choice KW - American Indians KW - Student Financial Aid KW - Occupational Information KW - Tribally Controlled Education KW - Allied Health Occupations Education KW - Minority Groups KW - Career Development KW - College Programs KW - Student Recruitment KW - Educational Resources KW - Black Students KW - Affirmative Action KW - Hispanic American Students KW - American Indian Education KW - Allied Health Occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62250414?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Revised by Charmika Schuster and edited by Ledis H N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Field Manual for Mental Health and Human Service Workers in Major Disasters. AN - 62247837; ED459382 AB - This field manual is intended for mental health workers and other human service providers who assist survivors following a disaster. It provides the basics of disaster mental health, with both specific and practical suggestions for workers. Essential information is included about disaster survivors' reactions and needs such as dealing with grief; anxiety over safety for themselves and others; eating and sleeping problems; and the need to talk over the events. Helping skills are described with guidance for when to refer survivors on for further professional assistance. Specific information is provided on how to assist potential risk groups such as children; older adults; people with mental disorders; people in group facilities; and different cultural and ethic groups. The material in this manual is condensed from material contained in the Training and Manual for Mental Health and Human Service Workers in Major Disasters, Second Edition. (JDM) AU - DeWolfe, Deborah J. Y1 - 2000 PY - 2000 DA - 2000 SP - 35 PB - Center for Mental Health Services, National Mental Health Services Knowledge Exchange Network, P.O. Box 42490, Washington, DC 20015. Tel: 800-789-2647 (Toll Free); Tel: 301-443-9006 (TTY); Fax: 301-984-8796; Web site: http://www.mentalhealth.org. KW - ERIC, Resources in Education (RIE) KW - Counselors KW - Practitioners KW - Crisis Intervention KW - Human Services KW - Terrorism KW - Counselor Training KW - National Programs KW - Individual Needs KW - Natural Disasters KW - Training Methods KW - Emergency Programs KW - Mental Health Workers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62247837?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Edited by Diana Nordboe. For the Training Manual, N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Psychosocial Issues for Children and Adolescents in Disasters. Second Edition. AN - 62247832; ED459384 AB - Major natural and human-caused disasters deeply affect children, and they have a special vulnerability to such events. The importance of providing crisis counseling recovery assistance within the context of their special world cannot be over emphasized. The information in this manual provides both theory and guidance to individuals concerned with the mental health needs of children who experience major disasters. It is designed as a supplement to the Manual for Mental Health and Human Service Workers in Major Disasters. At the time of the disaster, children are often left to the care of unfamiliar persons and provided limited explanations about what occurred. Specifics of how the many aspects of a disaster affect children are explained, and particularly how their reactions differ from adults. Chapters include: (1) "The World of Childhood and the Developing Child"; (2) "Reactions of Children to Disasters"; (3) "Helping the Child and Family"; and (4) "Guidelines for Caregivers, Mental Health and Human Service Workers." Appendix A is Agency Assistance in Disasters and Appendix B is Web Sites for additional resources. (Contains 30 references.) (JDM) AU - Speier, Anthony H. Y1 - 2000 PY - 2000 DA - 2000 SP - 58 PB - Center for Mental Health Services, National Mental Health Services Knowledge Exchange Network, P.O. Box 42490, Washington, DC 20015. Tel: 800-789-2647 (Toll Free); Tel: 301-443-9006 (TTY); Fax: 301-984-8796; Web site: http://www.mentalhealth.org. KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Counselors KW - Practitioners KW - Teachers KW - Terrorism KW - Individual Needs KW - Childhood Needs KW - Counseling KW - Children KW - Models KW - Crisis Intervention KW - Human Services KW - Child Development KW - Natural Disasters KW - Emergency Programs KW - Mental Health Workers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62247832?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Edited by Diana Nordboe. Cover page varies. N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Training Manual for Mental Health and Human Service Workers in Major Disasters. Second Edition. AN - 62247077; ED459383 AB - One of the changes experienced during the past decade has been the occurrence of human-caused disasters. With the rise in the number of such complex events, the Center for Mental Health Services has updated this training manual to assist mental health administrators and workers in developing the training components of crisis counseling. This manual introduces the trainer to the Crisis Counseling Program model, the scope and limits of the program, and elements required for effective service design and delivery. It presents essential information on how the disasters affect children and adults; the importance of tailoring the program to fit the community; descriptions of effective disaster mental health interventions; and strategies for preventing and managing worker stress. The manual contains the following sections: (1) "Background and Overview"; (2) "Responses to Disaster"; (3) "Disaster Reactions of Potential Risk Groups"; (4) "Stress Prevention and Management"; (5) "Setting up Disaster Mental Health Services Training"; (6) Comprehensive Training Course Outline"; and (7) "Additional Training Needs and Options." (Contains 56 references.) (JDM) AU - DeWolfe, Deborah J. Y1 - 2000 PY - 2000 DA - 2000 SP - 123 PB - Center for Mental Health Services, National Mental Health Services Knowledge Exchange Network, P.O. Box 42490, Washington, DC 20015. Tel: 800-789-2647 (Toll Free); Tel: 301-443-9006 (TTY); Fax: 301-984-8796; Web site: http://www.mentalhealth.org. KW - ERIC, Resources in Education (RIE) KW - Counselors KW - Crisis Intervention KW - Human Services KW - Terrorism KW - Counselor Training KW - Individual Needs KW - Natural Disasters KW - Training Methods KW - Emergency Programs KW - Mental Health Workers KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62247077?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Edited by Diana Nordboe. For the Field Manual, see N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Preventive Interventions under Managed Care: Mental Health and Substance Abuse Services. Special Report. AN - 62180815; ED468828 AB - Programs and services that prevent substance abuse and mental health disorders have the potential to lessen an enormous burden of suffering and to reduce both the cost of future treatment and lost productivity at work and home. The availability and accessibility of these interventions to Americans whose health care is provided by managed care organizations depend upon the services status as covered benefits. The ability to encourage managed care organizations to provide them may be enhanced with evidence of their effectiveness and their positive impact on cost. To compile and disseminate that evidence, this review of the literature presents information on preventive interventions to promote mental health and prevent substance abuse. After an extensive search of peer-reviewed journals, 54 articles from 1964 to 1999 that demonstrate positive outcomes from preventive substance abuse and mental health interventions are summarized in this document. The following six preventive services are recommended for consideration by managed care organizations: (1) prenatal and infancy home visits; (2) targeted cessation education and counseling for smokers, especially those who are pregnant; (3) targeted short-term mental health therapy; (4) self-care education for adults; (5) presurgical educational intervention with adults; (6) and brief counseling and advice to reduce alcohol use. Three appendixes contain preventive behavioral health statistics, past and present; cost analyses; and literature summaries. (Contains 156 references.) (GCP) AU - Dorfman, Sharon L. Y1 - 2000 PY - 2000 DA - 2000 SP - 86 PB - Center for Mental Health Services, Office of Managed Care, 5600 Fishers Lane, Room 15-87, Rockville, MD 20857. KW - ERIC, Resources in Education (RIE) KW - Program Effectiveness KW - Prevention KW - Substance Abuse KW - Health Maintenance Organizations KW - Intervention KW - Mental Health KW - Outcomes of Treatment KW - Health Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62180815?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Prepared under contract by SPECTRA for the Offices N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Scientific workshop on lesbian health 2000: steps for implementing the IOM report AN - 59885698; 2003-0904740 AB - Presents US Institute of Medicine recommendations for lesbian health care; sections on cancer, cardiovascular disease and obesity, health promotion and intervention, HIV/AIDS and STDs, life span development, mental health and substance abuse, research career development, research methodology, resiliency/health effects of homophobia, and service delivery and access to services. Published jointly with the Office on Women's Health, Office of Research on Women's Health, Gay and Lesbian Medical Association (GLMA), and the Lesbian Health Fund (LHF). JF - United States Department of Health and Human Services, 2000. Y1 - 2000///0, PY - 2000 DA - 0, 2000 PB - United States Department of Health and Human Services KW - Lesbians -- Mental health KW - Women -- Health KW - Discrimination against gays and lesbians -- United States KW - Lesbians -- Health KW - United States -- Health conditions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59885698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Scientific+workshop+on+lesbian+health+2000%3A+steps+for+implementing+the+IOM+report&rft.title=Scientific+workshop+on+lesbian+health+2000%3A+steps+for+implementing+the+IOM+report&rft.issn=&rft_id=info:doi/ L2 - http://www.4woman.gov/owh/pub/factsheets/lesbian.pdf LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Regional differences in Indian health, 1998-99 AN - 59865317; 2003-1113330 AB - Data on Indian Health Service programs and the health status of American Indians and Alaskan natives, 1989-91; focus on infant, maternal, and general mortality statistics and patient care statistics; 1994-98 data, chiefly; US. Also available in print. JF - United States Indian Health Service, 2000. Y1 - 2000///0, PY - 2000 DA - 0, 2000 PB - United States Indian Health Service KW - United States -- Health conditions -- Statistics KW - Alaska -- Native races -- Health KW - Public health -- United States -- Statistics KW - Indians -- Health -- Statistics KW - Indians -- Mortality -- Statistics KW - United States -- Health policy KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59865317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Regional+differences+in+Indian+health%2C+1998-99&rft.title=Regional+differences+in+Indian+health%2C+1998-99&rft.issn=&rft_id=info:doi/ L2 - http://www.ihs.gov/PublicInfo/Publications/trends98/master.pdf LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Indian Health Service N1 - Document feature - chart(s), index(es), map(s), table(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Child health USA 2000 AN - 59829363; 2000-1103710 AB - Health status and service needs of US children; covers target populations of Title V funding: infants, children, adolescents, children with special health care needs, and women of childbearing age. JF - United States Department of Health and Human Services, 2000. Y1 - 2000///0, PY - 2000 DA - 0, 2000 PB - United States Department of Health and Human Services KW - United States -- Health conditions -- Statistics KW - Women -- Health -- Statistics KW - Youth -- Health -- Statistics KW - Child health -- United States -- Statistics KW - Maternal and infant welfare -- United States -- Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59829363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Child+health+USA+2000&rft.title=Child+health+USA+2000&rft.issn=&rft_id=info:doi/ L2 - http://www.mchirc.net/CH-USA.htm LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Document feature - bibl(s), il(s), table(s), chart(s), map(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - How geology affects mine drainage prediction AN - 52187368; 2001-070504 JF - Prediction of water quality at surface coal mines AU - Brady, Keith AU - Hornberger, Roger AU - Chisholm, William AU - Sames, Gary A2 - Kleinmann, Robert L. P. Y1 - 2000 PY - 2000 DA - 2000 PB - West Virginia University, Natural Mine Land Reclamation Center, Morgantown, WV KW - hydrology KW - bedrock KW - water quality KW - North America KW - mines KW - petrology KW - overburden KW - acid mine drainage KW - surface water KW - rivers and streams KW - coal mines KW - watersheds KW - prediction KW - pollution KW - paleoclimatology KW - weathering KW - environmental effects KW - ground water KW - mineral composition KW - Appalachian Basin KW - sulfur KW - geochemistry KW - pH KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52187368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brady%2C+Keith%3BHornberger%2C+Roger%3BChisholm%2C+William%3BSames%2C+Gary&rft.aulast=Brady&rft.aufirst=Keith&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=How+geology+affects+mine+drainage+prediction&rft.title=How+geology+affects+mine+drainage+prediction&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 87 N1 - PubXState - WV N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Hydrology of the Appalachian bituminous coal basin AN - 52186160; 2001-070505 JF - Prediction of water quality at surface coal mines AU - Callaghan, Thomas AU - Brady, Keith AU - Chisholm, William AU - Sames, Gary A2 - Kleinmann, Robert L. P. Y1 - 2000 PY - 2000 DA - 2000 PB - West Virginia University, Natural Mine Land Reclamation Center, Morgantown, WV KW - United States KW - water quality KW - mining KW - preferential flow KW - coal fields KW - environmental effects KW - bituminous coal KW - ground water KW - fractures KW - sedimentary rocks KW - Appalachian Basin KW - coal KW - geochemistry KW - climate KW - hydrology KW - North America KW - drainage KW - surface water KW - prediction KW - pollution KW - hydrochemistry KW - aquifers KW - water wells KW - permeability KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52186160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Callaghan%2C+Thomas%3BBrady%2C+Keith%3BChisholm%2C+William%3BSames%2C+Gary&rft.aulast=Callaghan&rft.aufirst=Thomas&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hydrology+of+the+Appalachian+bituminous+coal+basin&rft.title=Hydrology+of+the+Appalachian+bituminous+coal+basin&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 66 N1 - PubXState - WV N1 - Document feature - illus. incl. 4 tables, sects. N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Static tests for coal mining acid mine drainage prediction in the Eastern U.S. AN - 52180298; 2001-070506 JF - Prediction of water quality at surface coal mines AU - Skousen, Jeff AU - Perry, Eric AU - Leavitt, Bruce AU - Sames, Gary AU - Chisholm, William AU - Cecil, C Blaine AU - Hammack, Richard A2 - Kleinmann, Robert L. P. Y1 - 2000 PY - 2000 DA - 2000 PB - West Virginia University, Natural Mine Land Reclamation Center, Morgantown, WV KW - United States KW - water quality KW - mines KW - overburden KW - acid mine drainage KW - coal mines KW - characterization KW - prediction KW - pollution KW - Eastern U.S. KW - simulation KW - weathering KW - measurement KW - models KW - transport KW - sulfur KW - leaching KW - discharge KW - pH KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52180298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Skousen%2C+Jeff%3BPerry%2C+Eric%3BLeavitt%2C+Bruce%3BSames%2C+Gary%3BChisholm%2C+William%3BCecil%2C+C+Blaine%3BHammack%2C+Richard&rft.aulast=Skousen&rft.aufirst=Jeff&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Static+tests+for+coal+mining+acid+mine+drainage+prediction+in+the+Eastern+U.S.&rft.title=Static+tests+for+coal+mining+acid+mine+drainage+prediction+in+the+Eastern+U.S.&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 71 N1 - PubXState - WV N1 - Document feature - illus. incl. 7 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Overburden sampling considerations AN - 52178410; 2001-070508 JF - Prediction of water quality at surface coal mines AU - Block, Fred AU - Tarantino, Joseph AU - Hornberger, Roger AU - Brady, Keith AU - Donovan, Joseph AU - Sames, Gary AU - Chisholm, William A2 - Kleinmann, Robert L. P. Y1 - 2000 PY - 2000 DA - 2000 PB - West Virginia University, Natural Mine Land Reclamation Center, Morgantown, WV KW - water quality KW - mines KW - overburden KW - acid mine drainage KW - statistical analysis KW - coal mines KW - pollution KW - coal seams KW - weathering KW - cores KW - variations KW - measurement KW - ground water KW - models KW - boreholes KW - sampling KW - infiltration KW - leaching KW - accuracy KW - pore water KW - instruments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52178410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Block%2C+Fred%3BTarantino%2C+Joseph%3BHornberger%2C+Roger%3BBrady%2C+Keith%3BDonovan%2C+Joseph%3BSames%2C+Gary%3BChisholm%2C+William&rft.aulast=Block&rft.aufirst=Fred&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Overburden+sampling+considerations&rft.title=Overburden+sampling+considerations&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 59 N1 - PubXState - WV N1 - Document feature - 6 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - A back analysis method based on virtual work principle; application to some geotechnical problems AN - 52161378; 2002-006812 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Deng, Desheng AU - Minh Duc, Nguyen A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1339 EP - 1346 PB - A. A. Balkema, Rotterdam VL - 4 KW - models KW - computer programs KW - technology KW - geologic hazards KW - loading KW - tunnels KW - data processing KW - land subsidence KW - equations KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52161378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=A+back+analysis+method+based+on+virtual+work+principle%3B+application+to+some+geotechnical+problems&rft.au=Deng%2C+Desheng%3BMinh+Duc%2C+Nguyen&rft.aulast=Deng&rft.aufirst=Desheng&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1339&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - computer programs; data processing; design; equations; geologic hazards; land subsidence; loading; models; rock mechanics; technology; tunnels ER - TY - JOUR T1 - Development of an interactive 3D visualization program for the analysis of geotechnical information AN - 52161329; 2002-006811 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Song, W K AU - Kim, K E AU - Park, H D A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1335 EP - 1337 PB - A. A. Balkema, Rotterdam VL - 4 KW - technology KW - Far East KW - three-dimensional models KW - data processing KW - Korea KW - digital terrain models KW - simulation KW - rock mechanics KW - computer programs KW - visualization KW - boreholes KW - Asia KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52161329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Development+of+an+interactive+3D+visualization+program+for+the+analysis+of+geotechnical+information&rft.au=Song%2C+W+K%3BKim%2C+K+E%3BPark%2C+H+D&rft.aulast=Song&rft.aufirst=W&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1335&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 2 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - Asia; boreholes; computer programs; data processing; digital terrain models; Far East; Korea; rock mechanics; simulation; technology; three-dimensional models; visualization ER - TY - JOUR T1 - Blasting optimization using seismic analysis and x-ray fluorescence spectroscopy AN - 52158021; 2002-006815 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Hopkins, Deborah AU - Haught, Ramsey AU - Karaca, Murat A AU - Turler, Daniel AU - Myer, Larry AU - Kemeny, John M AU - Lever, Paul AU - Lowery, Mary L A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1361 EP - 1367 PB - A. A. Balkema, Rotterdam VL - 4 KW - mining KW - technology KW - geophysical methods KW - optimization KW - equations KW - research KW - seismic methods KW - rock mechanics KW - safety KW - blasting KW - mining geology KW - X-ray fluorescence spectra KW - spectra KW - drilling KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52158021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Blasting+optimization+using+seismic+analysis+and+x-ray+fluorescence+spectroscopy&rft.au=Hopkins%2C+Deborah%3BHaught%2C+Ramsey%3BKaraca%2C+Murat+A%3BTurler%2C+Daniel%3BMyer%2C+Larry%3BKemeny%2C+John+M%3BLever%2C+Paul%3BLowery%2C+Mary+L&rft.aulast=Hopkins&rft.aufirst=Deborah&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1361&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - blasting; drilling; equations; geophysical methods; mining; mining geology; optimization; research; rock mechanics; safety; seismic methods; spectra; technology; X-ray fluorescence spectra ER - TY - JOUR T1 - Rock strength determination using a new true triaxial loading apparatus, and the inadequacy of Mohr-type failure criteria AN - 52156586; 2002-006809 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Chang, C AU - Haimson, Bezalel C A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1321 EP - 1327 PB - A. A. Balkema, Rotterdam VL - 4 KW - failures KW - strength KW - loading KW - stress KW - equations KW - triaxial tests KW - new methods KW - instruments KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Rock+strength+determination+using+a+new+true+triaxial+loading+apparatus%2C+and+the+inadequacy+of+Mohr-type+failure+criteria&rft.au=Chang%2C+C%3BHaimson%2C+Bezalel+C&rft.aulast=Chang&rft.aufirst=C&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 29 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - design; equations; failures; instruments; loading; new methods; rock mechanics; strength; stress; triaxial tests ER - TY - JOUR T1 - Experimental study on the stability of dam foundation in consideration of the effect of the concrete plug treatments AN - 52156545; 2002-006796 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Nakashima, S AU - Kishida, K AU - Adachi, T AU - Izu, Y A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1225 EP - 1232 PB - A. A. Balkema, Rotterdam VL - 4 KW - experimental studies KW - strength KW - stability KW - equations KW - concrete KW - rock mechanics KW - models KW - foundations KW - dams KW - gravity dams KW - construction materials KW - consolidation KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Experimental+study+on+the+stability+of+dam+foundation+in+consideration+of+the+effect+of+the+concrete+plug+treatments&rft.au=Nakashima%2C+S%3BKishida%2C+K%3BAdachi%2C+T%3BIzu%2C+Y&rft.aulast=Nakashima&rft.aufirst=S&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - concrete; consolidation; construction materials; dams; equations; experimental studies; foundations; gravity dams; models; rock mechanics; stability; strength ER - TY - JOUR T1 - Uncertainty in basic properties of intact rocks AN - 52156497; 2002-006806 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Kulhawy, Fred H AU - Prakoso, Widjojo A A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1301 EP - 1305 PB - A. A. Balkema, Rotterdam VL - 4 KW - physical properties KW - testing KW - properties KW - equations KW - rocks KW - accuracy KW - uncertainty KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Uncertainty+in+basic+properties+of+intact+rocks&rft.au=Kulhawy%2C+Fred+H%3BPrakoso%2C+Widjojo+A&rft.aulast=Kulhawy&rft.aufirst=Fred&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1301&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - accuracy; equations; physical properties; properties; rock mechanics; rocks; testing; uncertainty ER - TY - JOUR T1 - A new test for rock strength; double-punch test AN - 52156355; 2002-006807 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Chau, K T AU - Wei, X X A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1307 EP - 1313 PB - A. A. Balkema, Rotterdam VL - 4 KW - strength KW - double punch tests KW - testing KW - compression KW - new methods KW - instruments KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=A+new+test+for+rock+strength%3B+double-punch+test&rft.au=Chau%2C+K+T%3BWei%2C+X+X&rft.aulast=Chau&rft.aufirst=K&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1307&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - compression; double punch tests; instruments; new methods; rock mechanics; strength; testing ER - TY - JOUR T1 - Discrete fracture network analysis of foundation grouting AN - 52156178; 2002-006816 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Shuttle, D A AU - Dershowitz, W AU - Glynn, E AU - Burch, S AU - Novak, T A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1369 EP - 1376 PB - A. A. Balkema, Rotterdam VL - 4 KW - Greater Antilles KW - West Indies KW - Portugues Dam KW - grouting KW - Caribbean region KW - equations KW - rock mechanics KW - fractures KW - Antilles KW - foundations KW - boreholes KW - Puerto Rico KW - dams KW - Ponce Puerto Rico KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Discrete+fracture+network+analysis+of+foundation+grouting&rft.au=Shuttle%2C+D+A%3BDershowitz%2C+W%3BGlynn%2C+E%3BBurch%2C+S%3BNovak%2C+T&rft.aulast=Shuttle&rft.aufirst=D&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 9 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - Antilles; boreholes; Caribbean region; dams; equations; foundations; fractures; Greater Antilles; grouting; Ponce Puerto Rico; Portugues Dam; Puerto Rico; rock mechanics; West Indies ER - TY - JOUR T1 - AMT survey in high mountain area AN - 52156138; 2002-006810 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Cho, I K AU - Kim, J H AU - Baek, H J A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1331 EP - 1334 PB - A. A. Balkema, Rotterdam VL - 4 KW - civil engineering KW - Far East KW - geophysical surveys KW - geophysical methods KW - electrical methods KW - resistivity KW - Korea KW - seismic methods KW - rock mechanics KW - mountains KW - tunnels KW - underground installations KW - surveys KW - Asia KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=AMT+survey+in+high+mountain+area&rft.au=Cho%2C+I+K%3BKim%2C+J+H%3BBaek%2C+H+J&rft.aulast=Cho&rft.aufirst=I&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1331&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 9 N1 - Document feature - illus. incl. sects. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - Asia; civil engineering; electrical methods; Far East; geophysical methods; geophysical surveys; Korea; mountains; resistivity; rock mechanics; seismic methods; surveys; tunnels; underground installations ER - TY - JOUR T1 - Sensitivity analysis of THM simulation for high level underground nuclear waste repository AN - 52156037; 2002-006801 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Kwon, S AU - Park, B Y AU - Choi, J W AU - Kang, C H AU - Chang, K A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1265 EP - 1270 PB - A. A. Balkema, Rotterdam VL - 4 KW - hydraulic fracturing KW - Far East KW - engineering properties KW - site exploration KW - equations KW - Korea KW - simulation KW - rock mechanics KW - radioactive waste KW - sensitivity analysis KW - tunnels KW - underground installations KW - risk assessment KW - waste disposal KW - Asia KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52156037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Sensitivity+analysis+of+THM+simulation+for+high+level+underground+nuclear+waste+repository&rft.au=Kwon%2C+S%3BPark%2C+B+Y%3BChoi%2C+J+W%3BKang%2C+C+H%3BChang%2C+K&rft.aulast=Kwon&rft.aufirst=S&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 7 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - Asia; engineering properties; equations; Far East; hydraulic fracturing; Korea; radioactive waste; risk assessment; rock mechanics; sensitivity analysis; simulation; site exploration; tunnels; underground installations; waste disposal ER - TY - JOUR T1 - Assessing the disturbed rock zone (DRZ) around a 655 meter vertical shaft in salt using ultrasonic waves; an update AN - 52155945; 2002-006814 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Hardy, R D AU - Holcomb, D J A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1353 EP - 1360 PB - A. A. Balkema, Rotterdam VL - 4 KW - United States KW - chemically precipitated rocks KW - Eddy County New Mexico KW - elastic waves KW - New Mexico KW - equations KW - deformation KW - evaporites KW - rock mechanics KW - sedimentary rocks KW - Waste Isolation Pilot Plant KW - instruments KW - salt KW - amplitude KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52155945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Assessing+the+disturbed+rock+zone+%28DRZ%29+around+a+655+meter+vertical+shaft+in+salt+using+ultrasonic+waves%3B+an+update&rft.au=Hardy%2C+R+D%3BHolcomb%2C+D+J&rft.aulast=Hardy&rft.aufirst=R&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - amplitude; chemically precipitated rocks; deformation; Eddy County New Mexico; elastic waves; equations; evaporites; instruments; New Mexico; rock mechanics; salt; sedimentary rocks; United States; Waste Isolation Pilot Plant ER - TY - JOUR T1 - Determination of the fracture toughness of rock materials using the modified hoop test AN - 52155633; 2002-006805 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Baek, H J AU - Park, S U AU - Min, Kyoung Won AU - Cho, I K A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1295 EP - 1299 PB - A. A. Balkema, Rotterdam VL - 4 KW - processes KW - fractures KW - testing KW - mechanical properties KW - tensile strength KW - equations KW - hoop test KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52155633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Determination+of+the+fracture+toughness+of+rock+materials+using+the+modified+hoop+test&rft.au=Baek%2C+H+J%3BPark%2C+S+U%3BMin%2C+Kyoung+Won%3BCho%2C+I+K&rft.aulast=Baek&rft.aufirst=H&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1295&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 9 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - equations; fractures; hoop test; mechanical properties; processes; rock mechanics; tensile strength; testing ER - TY - JOUR T1 - Probabilistic key block analysis at Yucca Mountain AN - 52155586; 2002-006799 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Kicker, D C AU - Lin, M AU - Kemeny, John M AU - Stone, C A A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1249 EP - 1256 PB - A. A. Balkema, Rotterdam VL - 4 KW - United States KW - statistical analysis KW - geophysical methods KW - Nye County Nevada KW - seismic methods KW - rock mechanics KW - radioactive waste KW - fractures KW - discontinuities KW - seismicity KW - underground installations KW - risk assessment KW - waste disposal KW - Yucca Mountain KW - Nevada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52155586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Probabilistic+key+block+analysis+at+Yucca+Mountain&rft.au=Kicker%2C+D+C%3BLin%2C+M%3BKemeny%2C+John+M%3BStone%2C+C+A&rft.aulast=Kicker&rft.aufirst=D&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1249&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - discontinuities; fractures; geophysical methods; Nevada; Nye County Nevada; radioactive waste; risk assessment; rock mechanics; seismic methods; seismicity; statistical analysis; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Relationship between the critical dissipated energy per unit volume and the mechanical properties of different rocks AN - 52154760; 2002-006804 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Vasarhelyi, B AU - Deli, A AU - Galos, M AU - Van, P A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1289 EP - 1293 PB - A. A. Balkema, Rotterdam VL - 4 KW - experimental studies KW - strain KW - loading KW - stress KW - tensile strength KW - equations KW - uniaxial tests KW - rock mechanics KW - volume KW - testing KW - compression KW - rocks KW - energy KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52154760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Relationship+between+the+critical+dissipated+energy+per+unit+volume+and+the+mechanical+properties+of+different+rocks&rft.au=Vasarhelyi%2C+B%3BDeli%2C+A%3BGalos%2C+M%3BVan%2C+P&rft.aulast=Vasarhelyi&rft.aufirst=B&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1289&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - compression; energy; equations; experimental studies; loading; rock mechanics; rocks; strain; stress; tensile strength; testing; uniaxial tests; volume ER - TY - JOUR T1 - Application of GIS and remote sensing to geotechnical characterization of slopes AN - 52153843; 2002-006813 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Greuer, W AU - Young, D S A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1347 EP - 1352 PB - A. A. Balkema, Rotterdam VL - 4 KW - computer programs KW - failures KW - geographic information systems KW - data processing KW - information systems KW - applications KW - slope stability KW - satellite methods KW - rock mechanics KW - remote sensing KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52153843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Application+of+GIS+and+remote+sensing+to+geotechnical+characterization+of+slopes&rft.au=Greuer%2C+W%3BYoung%2C+D+S&rft.aulast=Greuer&rft.aufirst=W&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1347&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - applications; computer programs; data processing; failures; geographic information systems; information systems; remote sensing; rock mechanics; satellite methods; slope stability ER - TY - JOUR T1 - Dynamic and static compressions of rock-like spheres between two flat platens AN - 52153653; 2002-006797 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Chau, K T AU - Wei, X X AU - Wong, R H C AU - Yu, T X A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1233 EP - 1240 PB - A. A. Balkema, Rotterdam VL - 4 KW - dynamics KW - strength KW - mechanical properties KW - spheres KW - compression KW - rock mechanics KW - geometry KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52153653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Dynamic+and+static+compressions+of+rock-like+spheres+between+two+flat+platens&rft.au=Chau%2C+K+T%3BWei%2C+X+X%3BWong%2C+R+H+C%3BYu%2C+T+X&rft.aulast=Chau&rft.aufirst=K&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1233&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 42 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - compression; dynamics; geometry; mechanical properties; rock mechanics; spheres; strength ER - TY - JOUR T1 - Structural stability analysis for a high-level underground nuclear waste repository in granite AN - 52153274; 2002-006803 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Kwon, S AU - Park, B Y AU - Kang, C H AU - Chang, K A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1279 EP - 1285 PB - A. A. Balkema, Rotterdam VL - 4 KW - site exploration KW - igneous rocks KW - granites KW - data processing KW - stability KW - equations KW - simulation KW - rock mechanics KW - radioactive waste KW - computer programs KW - plutonic rocks KW - underground installations KW - crystalline rocks KW - waste disposal KW - construction KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52153274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Structural+stability+analysis+for+a+high-level+underground+nuclear+waste+repository+in+granite&rft.au=Kwon%2C+S%3BPark%2C+B+Y%3BKang%2C+C+H%3BChang%2C+K&rft.aulast=Kwon&rft.aufirst=S&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - computer programs; construction; crystalline rocks; data processing; design; equations; granites; igneous rocks; plutonic rocks; radioactive waste; rock mechanics; simulation; site exploration; stability; underground installations; waste disposal ER - TY - JOUR T1 - Durability of some building stones in Korea AN - 52153032; 2002-006808 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Min, Kyoung Won AU - Kim, Jaedong AU - Yim, Gil Jae A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1315 EP - 1319 PB - A. A. Balkema, Rotterdam VL - 4 KW - Far East KW - strength KW - igneous rocks KW - durability KW - granites KW - Korea KW - rock mechanics KW - plutonic rocks KW - cracks KW - sampling KW - buildings KW - testing KW - Asia KW - construction KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52153032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Durability+of+some+building+stones+in+Korea&rft.au=Min%2C+Kyoung+Won%3BKim%2C+Jaedong%3BYim%2C+Gil+Jae&rft.aulast=Min&rft.aufirst=Kyoung&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - Asia; buildings; construction; cracks; durability; Far East; granites; igneous rocks; Korea; plutonic rocks; rock mechanics; sampling; strength; testing ER - TY - JOUR T1 - Experimental study on failure behavior of tunnel in jointed rock mass under excavation AN - 52152990; 2002-006794 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Wong, Robina H C AU - Lin, P AU - Chau, K T AU - Tang, C A A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1211 EP - 1216 PB - A. A. Balkema, Rotterdam VL - 4 KW - fractures KW - failures KW - experimental studies KW - style KW - tunnels KW - underground installations KW - joints KW - equations KW - deformation KW - excavations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52152990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Experimental+study+on+failure+behavior+of+tunnel+in+jointed+rock+mass+under+excavation&rft.au=Wong%2C+Robina+H+C%3BLin%2C+P%3BChau%2C+K+T%3BTang%2C+C+A&rft.aulast=Wong&rft.aufirst=Robina+H&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1211&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - deformation; equations; excavations; experimental studies; failures; fractures; joints; rock mechanics; style; tunnels; underground installations ER - TY - JOUR T1 - Geological radioactive waste disposal project in France; conceptual model of a deep geological formation and underground research laboratory in Meuse/Haute-Marne site AN - 52152093; 2002-006800 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Hoteit, N AU - Ozanam, O AU - Su, K A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1257 EP - 1264 PB - A. A. Balkema, Rotterdam VL - 4 KW - Western Europe KW - engineering properties KW - site exploration KW - Europe KW - deformation KW - rock mechanics KW - radioactive waste KW - models KW - France KW - safety KW - Meuse France KW - underground installations KW - risk assessment KW - Haute-Marne France KW - waste disposal KW - construction KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52152093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Geological+radioactive+waste+disposal+project+in+France%3B+conceptual+model+of+a+deep+geological+formation+and+underground+research+laboratory+in+Meuse%2FHaute-Marne+site&rft.au=Hoteit%2C+N%3BOzanam%2C+O%3BSu%2C+K&rft.aulast=Hoteit&rft.aufirst=N&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - construction; deformation; design; engineering properties; Europe; France; Haute-Marne France; Meuse France; models; radioactive waste; risk assessment; rock mechanics; safety; site exploration; underground installations; waste disposal; Western Europe ER - TY - JOUR T1 - Discrete particle and laboratory modelling of core mechanics AN - 52152057; 2002-006795 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Holt, R M AU - Brandshaug, T AU - Cundall, P A A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1217 EP - 1224 PB - A. A. Balkema, Rotterdam VL - 4 KW - compaction KW - laboratory studies KW - experimental studies KW - sedimentary rocks KW - grain size KW - stress KW - sandstone KW - equations KW - clastic rocks KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52152057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Discrete+particle+and+laboratory+modelling+of+core+mechanics&rft.au=Holt%2C+R+M%3BBrandshaug%2C+T%3BCundall%2C+P+A&rft.aulast=Holt&rft.aufirst=R&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - clastic rocks; compaction; equations; experimental studies; grain size; laboratory studies; rock mechanics; sandstone; sedimentary rocks; stress ER - TY - JOUR T1 - Suggestions for data analysis of in-situ deformation measurements from salt and potash mines AN - 52151528; 2002-006798 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Kwon, S A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1243 EP - 1248 PB - A. A. Balkema, Rotterdam VL - 4 KW - mining KW - mines KW - chemically precipitated rocks KW - in situ KW - deformation KW - evaporites KW - rock mechanics KW - radioactive waste KW - sedimentary rocks KW - mining geology KW - waste disposal KW - potash KW - salt KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52151528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=Suggestions+for+data+analysis+of+in-situ+deformation+measurements+from+salt+and+potash+mines&rft.au=Kwon%2C+S&rft.aulast=Kwon&rft.aufirst=S&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - chemically precipitated rocks; deformation; evaporites; in situ; mines; mining; mining geology; potash; radioactive waste; rock mechanics; salt; sedimentary rocks; waste disposal ER - TY - JOUR T1 - An integrated approach to excavation design; a project within Canada's used fuel disposal program AN - 52151482; 2002-006802 JF - Proceedings of the ... North American Rock Mechanics Symposium AU - Chandler, N AU - Read, R AU - Cundall, P A AU - Potyondy, D AU - Detournay, Emmanuel AU - Young, R P AU - Lau, J S O A2 - Girard, Jami M. A2 - Liebman, Mark A2 - Breeds, Christopher D. A2 - Doe, Thomas Y1 - 2000 PY - 2000 DA - 2000 SP - 1271 EP - 1278 PB - A. A. Balkema, Rotterdam VL - 4 KW - processes KW - programs KW - technology KW - research KW - excavations KW - rock mechanics KW - radioactive waste KW - sedimentary rocks KW - claystone KW - Canada KW - underground installations KW - applications KW - waste disposal KW - clastic rocks KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52151482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.atitle=An+integrated+approach+to+excavation+design%3B+a+project+within+Canada%27s+used+fuel+disposal+program&rft.au=Chandler%2C+N%3BRead%2C+R%3BCundall%2C+P+A%3BPotyondy%2C+D%3BDetournay%2C+Emmanuel%3BYoung%2C+R+P%3BLau%2C+J+S+O&rft.aulast=Chandler&rft.aufirst=N&rft.date=2000-01-01&rft.volume=4&rft.issue=&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+North+American+Rock+Mechanics+Symposium&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth North American rock mechanics symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #04569 N1 - SubjectsTermNotLitGenreText - applications; Canada; clastic rocks; claystone; design; excavations; processes; programs; radioactive waste; research; rock mechanics; sedimentary rocks; technology; underground installations; waste disposal ER - TY - BOOK T1 - Does safety training make a difference? AN - 20194663; 10308214 AB - There are many factors that influence safety at sea for commercial fishermen. Factors as diverse and variable as weather, stability, human attitudes, regulations, fish management regimes, market forces, and even the value of the yen versus the dollar, affect safety in the fishing fleet. Traditional injury prevention programs have tried to control risk factors in the work environment, but many of the risk factors in commercial fishing are difficult to control. Thus, it is especially important to put an emphasis on factors that can be controlled. Training and education efforts in safety and survival are areas that we do have control over and play an important role in the safety equation of commercial fishers. Currently, training in emergency equipment, survival procedures, and drills is a requirement for documented fishing vessels in the U.S. that fish beyond the Federal Boundary Line. Thousands of fishers have been trained in Alaska and elsewhere since the early 1990s, but has there been any improvement in the fatality rate? And what role, if any, has safety training played in improving safety? These are the questions the Alaska Marine Safety Education Association (AMSEA) wanted to investigate. Most trainers who have been involved with safety training in fisheries have anecdotal evidence supporting the role training has played in survivability. These trainers can recall fishermen who lost a vessel and stated that the training they received was helpful. But these "successes" due to training had never been quantified before. In order words, was it just by coincidence that these people were helped? Would they have survived anyway? In 1995 AMSEA asked some people, well respected in the injury prevention field, to design a study that would investigate whether or not training really made a difference in fishing vessel loss survivability. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Dzugan, J Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 129 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - fishing vessels KW - Injuries KW - attitudes KW - Commercial fishing KW - Fisheries KW - prevention KW - Mortality KW - Weather KW - Training KW - INE, USA, Alaska KW - Education KW - safety engineering KW - Fish KW - survival KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20194663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dzugan%2C+J&rft.aulast=Dzugan&rft.aufirst=J&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=129&rft.isbn=&rft.btitle=Does+safety+training+make+a+difference%3F&rft.title=Does+safety+training+make+a+difference%3F&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - Coast Guard District 17 Search and Rescue AN - 20191495; 10308212 AB - The National Search and Rescue (SAR) Manual designates the Commander, Coast Guard (CG) Pacific Area as the SAR coordinator for the Pacific Maritime SAR Region and designates responsibility for the Northern Pacific Maritime SAR sub-region to the Commander, 17 super(th) CG District. The 17 super(th) CG's SAR responsibility within this area includes 33,000 miles of coastline and encompasses 3,853,500 square miles of water; an area much larger than the entire land mass of the continental U.S. The 17 super(th) District also possesses land SAR responsibilities for all of Southeast Alaska (SEAK) east of 141 degree W; all areas of the Alaska Peninsula south of 58 degree N; and all islands within Alaska which include all islands within Prince William Sound (PWS), Kodiak Island, the Aleutian Islands, the Pribilof Islands, St. Lawrence Island, and the Diomede Islands. Due to the large expanse of the area of responsibility (AOR), low population density, the relative scarcity of rapid-response surface assets, and the urgent nature of distress in the frigid maritime environment, CG air assets provide a critical element to SAR. There are many aspects to be considered due to the unique environment of the Alaskan AOR. These include, in part, the following: Large distances encountered; Mountainous terrain and unique weather environment inhibit "straight line" transit to scene; Low water temperatures which lead to low survivability rates for a person in the water (PIW); Low population densities; Few commercial alternative SAR resources; Large scope of inland SAR responsibilities; Poor communications; Multi-national cooperation/responsibilities; Remoteness and the related problems of: minimal fuel alternatives, minimal maintenance and crew support facilities, widely dispersed aeronautical navigation aids and weather reporting stations, lack of medical trauma centers, and sparse hospital facilities. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Rowe, G Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 102 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Fuels KW - Population density KW - INE, USA, Alaska, Kodiak I. KW - Canada, Maritime Prov. KW - Mountains KW - Islands KW - INE, USA, Alaska, Alaska Peninsula KW - responsibility KW - Weather KW - scarcity KW - Maintenance KW - INE, USA, Alaska, Pribilof I. KW - search and rescue KW - Coastal zone KW - Communications KW - navigation KW - IN, USA, Alaska, Aleutian Is. KW - fishing KW - water temperature KW - INE, USA, Alaska, Alaska Gulf, Prince William Sound KW - Hospitals KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20191495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Rowe%2C+G&rft.aulast=Rowe&rft.aufirst=G&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=102&rft.isbn=&rft.btitle=Coast+Guard+District+17+Search+and+Rescue&rft.title=Coast+Guard+District+17+Search+and+Rescue&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - USCG FVS dockside exam program and Alaskan FV casualty rates AN - 20185842; 10308209 AB - The Commercial Fishing Industry Vessel Safety Act of 1988 (CFIVSA) was enacted in response to the unabated losses of fishers and their vessels. In accordance with the Act, an inspection plan for fishing vessels, as well as a licensing plan for fishing vessel captains, has been submitted to Congress; however, sponsorship and legislative action are not forthcoming. Safety equipment regulations have been published (in 1991) and a Commercial Fishing Industry Vessel Safety Advisory Committee has been established as required by the Act. The U.S. Coast Guard (USCG) requirements established lifesaving equipment, communications equipment, navigation publications, and basic administrative and training requirements. These requirements apply to vessels based on length, tonnage, area of operation, the number of people aboard, and the vessel's service. Generally, the smaller the vessel, the smaller the crew, and the closer vessel operations are to shore-the less required by the regulations. There are presently minimal standards for construction, fire protection, electrical systems, watertight integrity, and stability. For new vessels, and vessels having undergone a major conversion, there are additional requirements. These additional requirements apply to few vessels at present. The requirements for lifesaving equipment and training do seem to have reduced the number of people killed in incidents related to vessel loss. Fishing vessel loss rates, while decreasing slightly, continue to remain at high levels. However, what were once fatal incidents are now being routinely survived. Insufficient time has passed for an analysis of the effects aging safety equipment, maintenance problems with safety equipment, or the lack of requirements for continuing training of crews, will have on this trend. If casualty rates remain the same, the failure of a piece of lifesaving equipment during an incident is a certainty. One event, accompanied by the failure of lifesaving equipment on a large vessel, or incorrect action by a poorly-trained crew, and this downward fatality trend could change instantly. What is most compelling from Marine Safety Information System (MSIS) data is the fact that over 90 percent of all fishing vessel casualties in Alaska occur on vessels under 200 gross tons, operated by unlicensed crews. These are the vessels the regulations were intended to help the most. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Medlicott, C Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 74 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - fishing vessels KW - Licensing KW - advisory committees KW - inspection KW - Commercial fishing KW - aging KW - Mortality KW - Fires KW - Training KW - Congress KW - INE, USA, Alaska KW - Maintenance KW - Coastal zone KW - USA KW - Communications KW - navigation KW - Legislation KW - Information systems KW - safety equipment KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20185842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Medlicott%2C+C&rft.aulast=Medlicott&rft.aufirst=C&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=USCG+FVS+dockside+exam+program+and+Alaskan+FV+casualty+rates&rft.title=USCG+FVS+dockside+exam+program+and+Alaskan+FV+casualty+rates&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - Alaskan commercial fishing vessel casualties: An overview, 1992 - 1996 AN - 20183604; 10308208 AB - The requirements of the Commercial Fishing Industry Vessel Safety Act of 1988 (CFIVSA) became effective in 1991 and were fully implemented for documented commercial fishing vessels in 1993. To assess the overall impact of these requirements on fishing industry vessel casualties in Alaskan waters, a review was conducted of all fishing vessel-related casualties reported to Seventeenth U.S. Coast Guard District marine safety offices between 1992 and 1996. The results of this review will be used by the Coast Guard to build on the successes of the CFIVSA by better targeting the efforts of the District's fishing vessel safety examiners as well as to establish partnerships with appropriate federal and state resource managers and commercial fishing vessel operators. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Blume, A Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 57 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Commercial fishing KW - Coastal zone KW - USA KW - fishing vessels KW - Reviews KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20183604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Blume%2C+A&rft.aulast=Blume&rft.aufirst=A&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=Alaskan+commercial+fishing+vessel+casualties%3A+An+overview%2C+1992+-+1996&rft.title=Alaskan+commercial+fishing+vessel+casualties%3A+An+overview%2C+1992+-+1996&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - Fishing vessel stability the effect of time and modifications on a vessel's stability AN - 20182692; 10308213 AB - At the First National Fishing Industry Safety and Health Workshop (1992), the author presented a paper which introduced the reader to the fundamental concepts of fishing vessel stability. The concepts were illustrated with a number of examples. The paper printed in the proceedings of the Workshop provides a good background for the current paper and will not be repeated here. Most people don't consider the fact that a vessel's stability is not constant. Of course, it is widely recognized that a vessel's stability is directly related to the loading of the vessel. Adding a large weight high up in the vessel will reduce stability. Some people may be aware that the lightship, or fundamental, characteristics of a vessel will change over time. In general, naval architects expect the lightship weight of a vessel to increase with time. The addition of equipment, tools, paint, etc., increases the vessel's weight. These become "permanent" additions over time. Owners and operators also often make "small" changes in the vessel. The cumulative effect of a series of small changes can drastically alter a vessel's stability. In this paper a 54-foot "high-speed" Alaskan seining vessel is examined to determine changes in the vessel's stability over time. A stability test was originally performed on this vessel in 1989 at a shipyard just after the delivery of the vessel. A second stability test was performed in 1997 after the vessel had been in service for 7 years. Examining the differences between the stability of the vessel as originally configured versus the vessel as modified over time is very enlightening. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Adee, B Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 112 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - fishing vessels KW - seining KW - fishing KW - Paints KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20182692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Adee%2C+B&rft.aulast=Adee&rft.aufirst=B&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=112&rft.isbn=&rft.btitle=Fishing+vessel+stability+the+effect+of+time+and+modifications+on+a+vessel%27s+stability&rft.title=Fishing+vessel+stability+the+effect+of+time+and+modifications+on+a+vessel%27s+stability&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - OSHA intervention in the Alaska fishing industry AN - 20153923; 10308210 AB - The mission of the Occupational Safety and Health Administration (OSHA) is to ensure that every working man and woman in the United States has a safe and healthful workplace. Thus, OSHA is interested in identifying and correcting workplace safety problems before a casualty occurs, not after. This includes the segment of the Alaska fishing industry which falls under OSHA's jurisdiction. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Noll, B Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 82 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Alaska KW - Federal regulations KW - Occupational safety KW - jurisdiction KW - intervention KW - safety regulations KW - fishing KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20153923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Noll%2C+B&rft.aulast=Noll&rft.aufirst=B&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=82&rft.isbn=&rft.btitle=OSHA+intervention+in+the+Alaska+fishing+industry&rft.title=OSHA+intervention+in+the+Alaska+fishing+industry&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - The financial and human costs of commercial fishing AN - 20144295; 10308207 AB - The American commercial fishing industry is diverse and often regionally specific. Its activities have long been financially important to local and regional economies. I would like to give you a brief overview of the importance of fishing and a view of the financial costs associated with a few aspects of the industry with particular focus on Alaska. I will cite some statistics as to the financial costs associated with various vessel losses and loss of life aboard fishing vessels. I will review some of the specific injuries that occur in Alaskan fisheries from the files of the Alaska Fisherman's Fund. I also have some data regarding USCG Search and Rescue (SAR) costs. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Herbert, J Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 40 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Alaska KW - fishing vessels KW - Injuries KW - search and rescue KW - Commercial fishing KW - funds KW - Reviews KW - Economics KW - Fisheries KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20144295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Herbert%2C+J&rft.aulast=Herbert&rft.aufirst=J&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=40&rft.isbn=&rft.btitle=The+financial+and+human+costs+of+commercial+fishing&rft.title=The+financial+and+human+costs+of+commercial+fishing&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - Why safety is "Good Business" AN - 20144242; 10308211 AB - The North Pacific Fishing Vessel Owners' Association (NPFVOA) Vessel Safety Program was established in 1985, in cooperation with the U.S. Coast Guard, as a voluntary effort to improve the commercial fishing industry's unacceptably high casualty rate through education and hands-on training. My comments here are based on first-hand observations of the participants whom we most typically service -- Seattle-based fishermen who operate in Alaska. Although our portable training programs have been held as far north at the Pribilof Islands and as far south as the Hawaiian Islands, the level of training participation NPFVOA sees locally far exceeds anywhere else in the country. Participation in our training programs to date (1997) has exceeded 17,000 and annual attendance has generally stabilized since activity spiked to meet new regulations in the early 1990s. The majority of our training activity is for safety classes which are not required, but which are designed to address major safety concerns. This program has largely been successful because it is a non-profit organization with a proactive membership base representing commercial fishermen of all gear types--trollers, seiners, longliners, trawlers, and processors -- who originally helped identify the major causes of accidents in the North Pacific, and who have continued to build and use these programs for training their crews. It is truly a program by fishermen for fishermen. During my involvement with this program for the past 13 years, I have witnessed an overall heightened safety awareness, and vast improvements in safety attitudes and practices. In fact, crews commonly state that they would never consider doing a number of things the way they did 10, or even 5 years ago! As a direct result, we are seeing welcomed improvements in casualty statistics in the North Pacific. JF - SECOND NATIONAL FISHING INDUSTRY SAFETY AND HEALTH WORKSHOP. AU - Hughes, L Y1 - 2000 PY - 2000 DA - 2000 SP - 1 EP - 98 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - fishing vessels KW - Training KW - INE, USA, Alaska KW - attitudes KW - INE, USA, Alaska, Pribilof I. KW - nonprofit organizations KW - Commercial fishing KW - Coastal zone KW - Accidents KW - Education KW - Islands KW - IN, North Pacific KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20144242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hughes%2C+L&rft.aulast=Hughes&rft.aufirst=L&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=98&rft.isbn=&rft.btitle=Why+safety+is+%22Good+Business%22&rft.title=Why+safety+is+%22Good+Business%22&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Healthy People 2010. Conference Edition: Partnerships for Health in the New Millennium. Held on January 24-28, 2000. Volume 2 AN - 18164015; 4831098 AB - ; Contents: Maternal, Infant, and Child Health; Medical Product Safety; Mental Health and Mental Disorders; Nutrition and Overweight; Occupational Safety and Health; Oral Health; Physical Activity and Fitness; Public Health Infrastructure; Respiratory Diseases; Sexually Transmitted Diseases; Substance Abuse; Tobacco Use; Vision and Hearing; Tracking Healthy People 2010 (Introduction, Major Data Sources for Healthy People 2010). Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 654 KW - Physical Education Index KW - PB2000103277 KW - Obesity KW - Physical fitness KW - Mental health KW - Health KW - Diseases KW - Nutrition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18164015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Physical+Education+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=654&rft.isbn=&rft.btitle=Healthy+People+2010.+Conference+Edition%3A+Partnerships+for+Health+in+the+New+Millennium.+Held+on+January+24-28%2C+2000.+Volume+2&rft.title=Healthy+People+2010.+Conference+Edition%3A+Partnerships+for+Health+in+the+New+Millennium.+Held+on+January+24-28%2C+2000.+Volume+2&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - SuppNotes - Available from NTIS: 1-800-553-NTIS (USA); (703)605-6000 (other countries); fax at (703)605-6900; orders[at]ntis.fedworld.gov. NTIS Prices: PC A99/MF A06 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Lifetime Persistence and Clonality of Chromosome Aberrations in the Peripheral Blood of Mice Acutely Exposed to Ionizing Radiation AN - 17856096; 5973453 AB - As the measurement of chromosomal translocations increases in popularity for quantifying prior radiation exposure, information on the possible decline of these 'stableâ aberrations over time is urgently needed. We report here information about the persistence of radiation-induced chromosome aberrations in vivo over the life span of a rodent. Female C57BL/6 mice were given a single whole-body acute exposure of 0, 1, 2, 3 or 4 Gy 137Cs gamma rays at 8 weeks of age. Chromosome aberrations were analyzed from peripheral blood samples at various intervals between 1 day and 21 months after exposure. Aberrations were detected by painting chromosomes 2 and 8. Translocations decreased dramatically during the first 3 months after irradiation, beyond which time the frequencies remained relatively constant out to 1 year, when the effects of aging and clonal expansion became significant. Both reciprocal and nonreciprocal translocations increased with age in the unexposed control animals and were involved in clones. As expected of unstable aberrations, dicentrics decreased rapidly after exposure and reached baseline levels within 3 months. These results indicate that the persistence of translocations induced by ionizing radiation is complicated by aging and clonal expansion and that these factors must be considered when quantifying translocations at long times after exposure. These results have implications for biological dosimetry in human populations. JF - Radiation Research AU - Spruill, MD AU - Nelson, DO AU - Ramsey, MJ AU - Nath, J AU - Tucker, J D AD - Toxicology and Molecular Biology Branch, MS 3014, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505 Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 110 EP - 121 PB - Radiation Research Society VL - 153 IS - 1 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Chromosome translocations KW - Radiation KW - Ionizing radiation KW - Aging KW - Life span KW - Dosimetry KW - Peripheral blood KW - chromosome 2 KW - Chromosome aberrations KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17856096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Lifetime+Persistence+and+Clonality+of+Chromosome+Aberrations+in+the+Peripheral+Blood+of+Mice+Acutely+Exposed+to+Ionizing+Radiation&rft.au=Spruill%2C+MD%3BNelson%2C+DO%3BRamsey%2C+MJ%3BNath%2C+J%3BTucker%2C+J+D&rft.aulast=Spruill&rft.aufirst=MD&rft.date=2000-01-01&rft.volume=153&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282000%291532.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=153&page=110 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Radiation; Chromosome translocations; Ionizing radiation; Dosimetry; Life span; Aging; chromosome 2; Peripheral blood; Chromosome aberrations DO - http://dx.doi.org/10.1043/0033-7587(2000)153<0110:LPACOC>2.0.CO;2 ER -