TY - JOUR T1 - Blood pressure, left ventricular mass, and lead exposure in battery manufacturing workers. AN - 71022121; 11439398 AB - Although debate about the relationship between lead and blood pressure has focused on low environmental lead levels, industrial exposure remains a concern. We measured blood pressure and left ventricular mass (LVM) in 108 battery manufacturing workers, and calculated cumulative and historic average measures of blood lead. Diastolic pressure increased with increasing lead levels, with a significant (P = 0.04) 5 mmHg difference in mean pressure between the highest and lowest cumulative exposure levels. Diastolic pressure increased with the log of cumulative lead (P = 0.06). Both hypertension (defined as currently medicated or systolic > 160 mmHg or diastolic > 95 mmHg) and LVM increased nonsignificantly with increasing lead exposure (P-values > or = 0.17 for hypertension and > or = 0.20 for LVM). We found a small effect of blood lead on diastolic blood pressure, particularly for a cumulative measure of exposure, but no convincing evidence of associations between lead and other blood-pressure-related outcomes. Published 2001 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Tepper, A AU - Mueller, C AU - Singal, M AU - Sagar, K AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. atepper@cdc.gov Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 63 EP - 72 VL - 40 IS - 1 SN - 0271-3586, 0271-3586 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Anthropometry KW - Odds Ratio KW - Blood Pressure KW - Logistic Models KW - Humans KW - Echocardiography KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Lead -- adverse effects KW - Hypertension -- chemically induced KW - Hypertrophy, Left Ventricular -- diagnostic imaging KW - Hypertension -- epidemiology KW - Occupational Exposure -- adverse effects KW - Hypertrophy, Left Ventricular -- epidemiology KW - Hypertrophy, Left Ventricular -- chemically induced KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71022121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Blood+pressure%2C+left+ventricular+mass%2C+and+lead+exposure+in+battery+manufacturing+workers.&rft.au=Tepper%2C+A%3BMueller%2C+C%3BSingal%2C+M%3BSagar%2C+K&rft.aulast=Tepper&rft.aufirst=A&rft.date=2001-07-01&rft.volume=40&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peripheral neuropathy in workers exposed to nitromethane. AN - 70990132; 11439403 AB - Two workers from a headlight subassembly plant developed severe peripheral neuropathy. These workers had extensive, but brief (1-2 months) dermal and inhalational exposure to nitromethane, a solvent. Environmental sampling was performed for nitromethane and ethyl cyanoacrylate. Medical records, including electrodiagnostic studies, were reviewed. Literature on nitromethane, ethyl cyanoacrylate, and other exposures in the workplace was reviewed. Electromyography and nerve conduction studies performed on these patients were consistent with a severe, axonal neuropathy. No etiology was discovered despite an extensive medical evaluation. Environmental sampling revealed exposure to nitromethane at the threshold limit value. The history of acute onset of severe peripheral neuropathy temporally associated with exposure to nitromethane is suggestive of a toxic neuropathy. While it cannot be definitively concluded that these two workers developed peripheral neuropathy secondary to exposures at work, occupational exposure to nitromethane appears to be the most likely etiology. Copyright 2001 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Page, E H AU - Pajeau, A K AU - Arnold, T C AU - Fincher, A R AU - Goddard, M J AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226-1998, USA. edp7@cdc.gov Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 107 EP - 113 VL - 40 IS - 1 SN - 0271-3586, 0271-3586 KW - Cyanoacrylates KW - 0 KW - Nitroparaffins KW - Solvents KW - Methane KW - OP0UW79H66 KW - nitromethane KW - RU5WG8C3F4 KW - Index Medicus KW - Threshold Limit Values KW - Humans KW - Cyanoacrylates -- analysis KW - Cyanoacrylates -- adverse effects KW - Adult KW - Electromyography KW - Male KW - Female KW - Peripheral Nervous System Diseases -- physiopathology KW - Methane -- analysis KW - Nitroparaffins -- analysis KW - Solvents -- analysis KW - Methane -- analogs & derivatives KW - Solvents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Nitroparaffins -- adverse effects KW - Methane -- adverse effects KW - Peripheral Nervous System Diseases -- chemically induced KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70990132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Peripheral+neuropathy+in+workers+exposed+to+nitromethane.&rft.au=Page%2C+E+H%3BPajeau%2C+A+K%3BArnold%2C+T+C%3BFincher%2C+A+R%3BGoddard%2C+M+J&rft.aulast=Page&rft.aufirst=E&rft.date=2001-07-01&rft.volume=40&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis. AN - 70978621; 11442229 AB - This report updates and consolidates all previous U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body fluids that might contain hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). Recommendations for HBV postexposure management include initiation of the hepatitis B vaccine series to any susceptible, unvaccinated person who sustains an occupational blood or body fluid exposure. Postexposure prophylaxis (PEP) with hepatitis B immune globulin (HBIG) and/or hepatitis B vaccine series should be considered for occupational exposures after evaluation of the hepatitis B surface antigen status of the source and the vaccination and vaccine-response status of the exposed person. Guidance is provided to clinicians and exposed HCP for selecting the appropriate HBV PEP. Immune globulin and antiviral agents (e.g., interferon with or without ribavirin) are not recommended for PEP of hepatitis C. For HCV postexposure management, the HCV status of the source and the exposed person should be determined, and for HCP exposed to an HCV positive source, follow-up HCV testing should be performed to determine if infection develops. Recommendations for HIV PEP include a basic 4-week regimen of two drugs (zidovudine [ZDV] and lamivudine [3TC]; 3TC and stavudine [d4T]; or didanosine [ddI] and d4T) for most HIV exposures and an expanded regimen that includes the addition of a third drug for HIV exposures that pose an increased risk for transmission. When the source person's virus is known or suspected to be resistant to one or more of the drugs considered for the PEP regimen, the selection of drugs to which the source person's virus is unlikely to be resistant is recommended. In addition, this report outlines several special circumstances (e.g., delayed exposure report, unknown source person, pregnancy in the exposed person, resistance of the source virus to antiretroviral agents, or toxicity of the PEP regimen) when consultation with local experts and/or the National Clinicians' Post-Exposure Prophylaxis Hotline ([PEPline] 1-888-448-4911) is advised. Occupational exposures should be considered urgent medical concerns to ensure timely postexposure management and administration of HBIG, hepatitis B vaccine, and/or HIV PEP. JF - MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports AU - U.S. Public Health Service AD - U.S. Public Health Service Y1 - 2001/06/29/ PY - 2001 DA - 2001 Jun 29 SP - 1 EP - 52 VL - 50 SN - 1057-5987, 1057-5987 KW - Anti-HIV Agents KW - 0 KW - Hepatitis B Vaccines KW - Immunoglobulins KW - Index Medicus KW - Hepacivirus KW - Anti-HIV Agents -- therapeutic use KW - Hepatitis B virus -- immunology KW - Humans KW - Blood-Borne Pathogens KW - HIV KW - Immunoglobulins -- therapeutic use KW - Female KW - Pregnancy KW - Occupational Exposure KW - Hepatitis C -- prevention & control KW - Hepatitis B -- prevention & control KW - Hepatitis C -- transmission KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Health Personnel KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control KW - Hepatitis B -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70978621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.atitle=Updated+U.S.+Public+Health+Service+Guidelines+for+the+Management+of+Occupational+Exposures+to+HBV%2C+HCV%2C+and+HIV+and+Recommendations+for+Postexposure+Prophylaxis.&rft.au=U.S.+Public+Health+Service&rft.aulast=U.S.+Public+Health+Service&rft.aufirst=&rft.date=2001-06-29&rft.volume=50&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.issn=10575987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acceleration of mammary neoplasia in aromatase transgenic mice by 7,12-dimethylbenz[a]anthracene. AN - 70856326; 11369132 AB - Our studies using the aromatase transgenic mice model have shown that early exposure of mammary epithelium to in situ estrogen as a result of overexpression of aromatase predispose mammary tissue to preneoplastic changes. Here, we hypothesize that the preneoplastic changes induced by mammary estrogen in aromatase transgenic females may be susceptible to environmental carcinogens like 7,12-dimethylbenz[a]anthracene (DMBA), and may result in the acceleration and/or increase in the incidence of breast cancer. Results presented in this study show that tumors appeared in 25% of the mice that were treated with DMBA and all treated transgenic animals had microscopic evidence of neoplastic progression. Control non-transgenic females did not have significant changes even after treatment with DMBA. Consistent with increased neoplastic changes in DMBA-treated aromatase mice, we have seen an increase in the expression of genes involved in cell proliferation and cell cycle. We have also seen changes in the expression of oxidative stress markers and changes in estrogen-mediated growth factors. These studies indicate that more than one event is required for tumor formation, and that early estrogen exposure leading to preneoplastic changes in the mammary epithelial cells increases susceptibility to environmental carcinogens that may result in acceleration and/or an increase in the incidence of breast cancer. JF - Cancer letters AU - Keshava, N AU - Mandava, U AU - Kirma, N AU - Tekmal, R R AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2001/06/26/ PY - 2001 DA - 2001 Jun 26 SP - 125 EP - 133 VL - 167 IS - 2 SN - 0304-3835, 0304-3835 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Aromatase KW - EC 1.14.14.1 KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Carcinogenicity Tests KW - Incidence KW - Disease Models, Animal KW - Mice KW - Mice, Transgenic KW - Female KW - Mammary Neoplasms, Experimental -- chemically induced KW - Aromatase -- metabolism KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Mammary Neoplasms, Experimental -- epidemiology KW - 9,10-Dimethyl-1,2-benzanthracene -- administration & dosage KW - Aromatase -- genetics KW - Mammary Neoplasms, Experimental -- enzymology KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70856326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Acceleration+of+mammary+neoplasia+in+aromatase+transgenic+mice+by+7%2C12-dimethylbenz%5Ba%5Danthracene.&rft.au=Keshava%2C+N%3BMandava%2C+U%3BKirma%2C+N%3BTekmal%2C+R+R&rft.aulast=Keshava&rft.aufirst=N&rft.date=2001-06-26&rft.volume=167&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Estimation of no-effect-levels and potential organ toxicities of chemicals in humans using pharmaceutical clinical data and multicase software AN - 39403261; 3606070 AU - Matthews, E J AU - Contrera, J F Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39403261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Estimation+of+no-effect-levels+and+potential+organ+toxicities+of+chemicals+in+humans+using+pharmaceutical+clinical+data+and+multicase+software&rft.au=Matthews%2C+E+J%3BContrera%2C+J+F&rft.aulast=Matthews&rft.aufirst=E&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; URL: www.toxicology.org. Paper No. #637 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo genetic toxicology data in health risk assessment AN - 39390129; 3606190 AU - MacGregor, J T Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39390129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vivo+genetic+toxicology+data+in+health+risk+assessment&rft.au=MacGregor%2C+J+T&rft.aulast=MacGregor&rft.aufirst=J&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; URL: www.toxicology.org. Paper No. #653 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicogenomics and proteomics: Potential impact on pharmaceutical development and regulation AN - 39377909; 3601953 AU - MacGregor, J T Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39377909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Toxicogenomics+and+proteomics%3A+Potential+impact+on+pharmaceutical+development+and+regulation&rft.au=MacGregor%2C+J+T&rft.aulast=MacGregor&rft.aufirst=J&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Environmental Mutagen Society, 11250 Roger Bacon Drive, Suite 8, Reston, VA 20190-5202; URL: www.ems.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetically engineered organisms: A regulatory perspective AN - 39345771; 3601957 AU - Matheson, J C Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39345771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genetically+engineered+organisms%3A+A+regulatory+perspective&rft.au=Matheson%2C+J+C&rft.aulast=Matheson&rft.aufirst=J&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Environmental Mutagen Society, 11250 Roger Bacon Drive, Suite 8, Reston, VA 20190-5202; URL: www.ems.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Covariation between workplace physical and psychosocial stressors: evidence and implications for occupational health research and prevention AN - 18029662; 6001405 AB - There is increasing interest in distinguishing the effects of physical and psychosocial workplace stressors on the aetiology of work-related musculoskeletal disorders (MSD). Modest associations have been found between psychosocial stressors and MSD, such as intensive load, monotonous work and low job control. Interpretation of these results has been limited by likely covariation between physical and psychosocial stressors. This investigation examined exposure covariation among blue- and white-collar workers employed in a mass production manufacturing environment (N = 410). Physical stressors were assessed from questionnaire and accelerometry. Psychosocial stressors were assessed from questionnaire. Pearson and Spearman correlation coefficients were computed. An exploratory factor analysis procedure identified possible common factors linking specific physical and psychosocial stressors. Moderate to high correlations between some physical and psychosocial stressors showed evidence of covariation both across and within groups. Covariation was strongest among blue-collar production and low-status office workers. Factor analysis results showed considerable shared variance between some physical and psychosocial stressors, such as repetition and job control, suggesting that these disparate stressors manifest from common work organization factors that govern the structure of work. While recognizing the conceptual differences between physical and psychosocial stressors, these results call attention to the strong empirical relationships that can exist between some stressors in the workplace setting. To guard against ambiguous study findings that can occur when exposures are mixed, it is critical that future epidemiologic studies include information about the degree of association between task-level stressors. Future research on work organization determinants of task-level stressors, and their coincident occurrence in jobs with greater specialization, may provide promising new insights into the nature of risk for MSD and effective prevention strategies. JF - Ergonomics AU - MacDonald, LA AU - Karasek, R A AU - Punnett, L AU - Scharf, T AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-15, Cincinnati, OH 45226-1998, USA Y1 - 2001/06/10/ PY - 2001 DA - 2001 Jun 10 SP - 696 EP - 718 VL - 44 IS - 7 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - Prevention KW - Stress KW - Working conditions KW - Ergonomics KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18029662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Covariation+between+workplace+physical+and+psychosocial+stressors%3A+evidence+and+implications+for+occupational+health+research+and+prevention&rft.au=MacDonald%2C+LA%3BKarasek%2C+R+A%3BPunnett%2C+L%3BScharf%2C+T&rft.aulast=MacDonald&rft.aufirst=LA&rft.date=2001-06-10&rft.volume=44&rft.issue=7&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational health; Ergonomics; Working conditions; Stress; Prevention ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 70893528; 11386912 JF - JAMA AU - Schwetz, B A AD - Food and Drug Administration, USA. Y1 - 2001/06/06/ PY - 2001 DA - 2001 Jun 06 SP - 2705 VL - 285 IS - 21 SN - 0098-7484, 0098-7484 KW - Antiviral Agents KW - 0 KW - Aristolochic Acids KW - Narcotics KW - Phenanthrenes KW - Prodrugs KW - aristolochic acid I KW - 94218WFP5T KW - valganciclovir KW - GCU97FKN3R KW - Methadyl Acetate KW - L59OC40KWJ KW - Ganciclovir KW - P9G3CKZ4P5 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Phytotherapy KW - Arrhythmias, Cardiac -- chemically induced KW - United States Food and Drug Administration KW - Humans KW - Opioid-Related Disorders -- drug therapy KW - Drug Labeling KW - Cytomegalovirus Retinitis -- drug therapy KW - Antiviral Agents -- therapeutic use KW - AIDS-Related Opportunistic Infections -- drug therapy KW - Ganciclovir -- therapeutic use KW - Prodrugs -- therapeutic use KW - Dietary Supplements -- adverse effects KW - Narcotics -- adverse effects KW - Phenanthrenes -- adverse effects KW - Ganciclovir -- analogs & derivatives KW - Methadyl Acetate -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70893528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Schwetz%2C+B+A&rft.aulast=Schwetz&rft.aufirst=B&rft.date=2001-06-06&rft.volume=285&rft.issue=21&rft.spage=2705&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profile in response to chromium-induced cell stress in A549 cells AN - 879476413; 13861532 AB - Chromium (Cr) is a trace element required for life. Biological activities of Cr are complicated and remain to be fully investigated. It is known that the valence of Cr plays an important role in the biological activities of Cr. For example, Cr (VI) is classified as a metal carcinogen [1], but Cr (III) is widely used as a nutritional supplement [2, 3]. Establishment of a gene expression profile for Cr-induced cellular response is necessary to facilitate investigation of the biological activities of Cr. In the present study, a large-scale gene expression analysis was conducted using RNA of human lung epithelial cells after in vitro exposure to Cr (VI). Utilizing high-density oligonucleotide arrays representing 2400 genes, we observed that expression of 150 genes was up-regulated, and that of 70 genes were down-regulated by Cr (VI). Functional analysis of these responsive genes led to an outline of potential biological activities of Cr in six aspects. The gene expression profile reveals that Cr may involves in redox stress, calcium mobilization, energy metabolism, protein synthesis, cell cycle regulation and carcinogenesis in the cell. The results provide a critical clue for understanding molecular mechanisms of the biological activities of Cr. JF - Molecular and Cellular Biochemistry AU - Ye, Jianping AU - Shi, Xianglin AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 189 EP - 197 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 222 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Genetics Abstracts; Toxicology Abstracts KW - Molecular modelling KW - Epithelial cells KW - Protein biosynthesis KW - Energy metabolism KW - Chromium KW - Heavy metals KW - Cell cycle KW - Stress KW - Carcinogens KW - DNA microarrays KW - Trace elements KW - Gene expression KW - RNA KW - Lung KW - Dietary supplements KW - Carcinogenesis KW - Calcium mobilization KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879476413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Gene+expression+profile+in+response+to+chromium-induced+cell+stress+in+A549+cells&rft.au=Ye%2C+Jianping%3BShi%2C+Xianglin&rft.aulast=Ye&rft.aufirst=Jianping&rft.date=2001-06-01&rft.volume=222&rft.issue=1-2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1023%2FA%3A1017974415052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Molecular modelling; Protein biosynthesis; Chromium; Energy metabolism; Heavy metals; Cell cycle; Stress; Carcinogens; DNA microarrays; Trace elements; Gene expression; RNA; Lung; Dietary supplements; Carcinogenesis; Calcium mobilization DO - http://dx.doi.org/10.1023/A:1017974415052 ER - TY - JOUR T1 - On the mechanism of Cr (VI)-induced carcinogenesis: Dose dependence of uptake and cellular responses AN - 867744515; 13861536 AB - Cr (VI) compounds are widely used industrial chemicals and are recognized human carcinogens. The mechanisms of carcinogenesis associated with these compounds remain to be investigated. The present study focused on dose-dependence of Cr (VI)-induced uptake and cellular responses. The results show that Cr (VI) is able to enter the cells (human lung epithelial cell line A549) at low concentration (< 10 kM) and that the Cr (VI) uptake appears to be a combination of saturable transport and passive diffusion. Electron spin resonance (ESR) trapping measurements showed that upon stimulation with Cr (VI), A549 cells were able to generate reactive oxygen species (ROS). The amount of ROS generated depended on the Cr (VI) concentration. ROS generation involved NADPH-dependent flavoenzymes. Cr (VI) affected the following cellular parameters in a dose-dependent manner, (a) activation of nuclear transcription factors NF-B, and p53, (b) DNA damage, (c) induction of cell apoptosis, and (d) inhibition of cell proliferation. The activation of transcription factors was assessed by electrophoretic mobility shift assay and western blot analysis, DNA damage by single cell gel electrophoresis assay, cell apoptosis by DNA fragmentation assay, and cell proliferation by a non-radioactive ELISA kit. At the concentration range used in the present study, no thresholds were found in all of these cell responses to Cr (VI). The results may guide further research to better understand and evaluate the risk of Cr (VI)-induced carcinogenesis at low levels of exposure. JF - Molecular and Cellular Biochemistry AU - Liu, Kejian AU - HuslerSurname, John AU - Ye, Jianping AU - Leonard, Stephen S AU - Cutler, Debbie AU - Chen, Fei AU - Wang, Suwei AU - Zhang, Zhuo AU - Ding, Min AU - Wang, Liying AU - Shi, Xianglin AD - Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA, xshi@cdc.gov xshi@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 221 EP - 229 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 222 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Toxicology Abstracts KW - Western blotting KW - Epithelial cells KW - Enzyme-linked immunosorbent assay KW - Apoptosis KW - Carcinogens KW - Electrophoretic mobility KW - Trapping KW - Gel electrophoresis KW - p53 protein KW - DNA damage KW - DNA fragmentation KW - Reactive oxygen species KW - Lung KW - Transcription factors KW - NF-B protein KW - Carcinogenesis KW - Diffusion KW - Cell proliferation KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867744515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=On+the+mechanism+of+Cr+%28VI%29-induced+carcinogenesis%3A+Dose+dependence+of+uptake+and+cellular+responses&rft.au=Liu%2C+Kejian%3BHuslerSurname%2C+John%3BYe%2C+Jianping%3BLeonard%2C+Stephen+S%3BCutler%2C+Debbie%3BChen%2C+Fei%3BWang%2C+Suwei%3BZhang%2C+Zhuo%3BDing%2C+Min%3BWang%2C+Liying%3BShi%2C+Xianglin&rft.aulast=Liu&rft.aufirst=Kejian&rft.date=2001-06-01&rft.volume=222&rft.issue=1-2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1023%2FA%3A1017938918686 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Western blotting; Enzyme-linked immunosorbent assay; Apoptosis; Carcinogens; Electrophoretic mobility; Trapping; Gel electrophoresis; p53 protein; DNA fragmentation; DNA damage; Reactive oxygen species; Lung; Transcription factors; Carcinogenesis; NF-B protein; Diffusion; Cell proliferation DO - http://dx.doi.org/10.1023/A:1017938918686 ER - TY - JOUR T1 - Cell apoptosis induced by carcinogenic metals AN - 867744507; 13861531 AB - Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed. JF - Molecular and Cellular Biochemistry AU - Chen, Fei AU - Vallyathan, Val AU - Castranova, Vince AU - Shi, Xianglin AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA, Xshi@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 183 EP - 188 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 222 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Toxicology Abstracts KW - Vanadium KW - Arsenic KW - Apoptosis KW - Chromium KW - Heavy metals KW - Lipid peroxidation KW - Cancer KW - Inflammation KW - DNA damage KW - Reactive oxygen species KW - Reviews KW - Occupational exposure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867744507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Cell+apoptosis+induced+by+carcinogenic+metals&rft.au=Chen%2C+Fei%3BVallyathan%2C+Val%3BCastranova%2C+Vince%3BShi%2C+Xianglin&rft.aulast=Chen&rft.aufirst=Fei&rft.date=2001-06-01&rft.volume=222&rft.issue=1-2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1023%2FA%3A1017970330982 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Vanadium; DNA damage; Arsenic; Apoptosis; Reactive oxygen species; Chromium; Heavy metals; Reviews; Cancer; Lipid peroxidation; Occupational exposure; Inflammation DO - http://dx.doi.org/10.1023/A:1017970330982 ER - TY - JOUR T1 - Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells AN - 856761628; 13861519 AB - Occupational exposure to beryllium (Be) and Be compounds occurs in a wide range of industrial processes. A large number of workers are potentially exposed to this metal during manufacturing and processing, so there is a concern regarding the potential carcinogenic hazard of Be. Studies were performed to determine the carcinogenic potential of beryllium sulfate (BeSO sub(4)) in cultured mammalian cells. BALB/c-3T3 cells were treated with varying concentrations of BeSO sub(4) for 72 h and the transformation frequency was determined after 4 weeks of culturing. Concentrations from 50-200 kg BeSO sub(4)/ml, caused a concentration-dependent increase (9-41 fold) in transformation frequency. Non-transformed BALB/c-3T3 cells and cells from transformed foci induced by BeSO sub(4) were injected into both axillary regions of nude mice. All ten Be-induced transformed cell lines injected into nude mice produced fibrosarcomas within 50 days after cell injection. No tumors were found in nude mice receiving non-transformed BALB/c-3T3 cells 90 days post-injection. Gene amplification was investigated in K-ras, c-myc, c-fos, c-jun, c-sis, erb-B2 and p53 using differential PCR while random amplified polymorphic DNA fingerprinting was employed to detect genomic instability. Gene amplification was found in K-ras and c-jun, however no change in gene expression or protein level was observed in any of the genes by Western blotting. Five of the 10 transformed cell lines showed genetic instability using different random primers. In conclusion, these results indicate that BeSO sub(4) is capable of inducing morphological cell transformation in mammalian cells and that transformed cells induced by BeSO sub(4) are potentially tumorigenic. Also, cell transformation induced by BeSO sub(4) may be attributed, in part, to the gene amplification of K-ras and c-jun and some BeSO sub(4)-induced transformed cells possess neoplastic potential resulting from genomic instability. JF - Molecular and Cellular Biochemistry AU - Keshava, Nagalakshmi AU - Zhou, Gu AU - Spruill, Michelle AU - Ensell, Mang AU - Ong, Tong-man AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA, NKeshava@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 69 EP - 76 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 222 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Genetics Abstracts; Toxicology Abstracts KW - Transformation KW - Western blotting KW - Fibrosarcoma KW - Metals KW - ErbB-2 protein KW - Transformed cells KW - Tumors KW - c-Fos protein KW - c-Jun protein KW - p53 protein KW - Sulfate KW - K-Ras protein KW - DNA fingerprinting KW - Genomic instability KW - Mammalian cells KW - Transcription factors KW - Gene amplification KW - Beryllium KW - Polymerase chain reaction KW - Primers KW - Occupational exposure KW - c-Myc protein KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856761628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Carcinogenic+potential+and+genomic+instability+of+beryllium+sulphate+in+BALB%2Fc-3T3+cells&rft.au=Keshava%2C+Nagalakshmi%3BZhou%2C+Gu%3BSpruill%2C+Michelle%3BEnsell%2C+Mang%3BOng%2C+Tong-man&rft.aulast=Keshava&rft.aufirst=Nagalakshmi&rft.date=2001-06-01&rft.volume=222&rft.issue=1-2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1023%2FA%3A1017911306449 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Metals; Fibrosarcoma; Western blotting; ErbB-2 protein; Transformed cells; c-Fos protein; Tumors; c-Jun protein; Sulfate; p53 protein; DNA fingerprinting; K-Ras protein; Genomic instability; Mammalian cells; Gene amplification; Transcription factors; Beryllium; Polymerase chain reaction; Primers; c-Myc protein; Occupational exposure DO - http://dx.doi.org/10.1023/A:1017911306449 ER - TY - JOUR T1 - Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. AN - 85349389; pmid-11419817 AB - To describe the postmarketing safety data used in the risk assessment of cisapride and to summarize the regulatory actions of the Food and Drug Administration (FDA).The FDA analyzed reports of patients who developed QT prolongation, torsades de pointes, and ventricular arrhythmia in association with the use of cisapride to assess probable etiology and risk factors.While cisapride was being marketed from 1993-1999, the FDA received reports of the following patients: 117 who developed QT prolongation; 107, torsades de pointes; 16, polymorphic ventricular tachycardia; 18, ventricular fibrillation; 27, ventricular tachycardia; 25, cardiac arrest; 16, serious (unspecified) arrhythmia; and 15, sudden death; for a total of 341 individual patients affected, following use of cisapride. Eighty (23%) of the 341 patients died. Deaths were directly or indirectly associated with an arrhythmic event. Factors that suggested an association with cisapride included a temporal relationship between use of cisapride and arrhythmia, the absence of identified risk factors and other explanations for arrhythmia in some patients, and cases of positive dechallenge and rechallenge. In most individuals, the arrhythmia occurred in the presence of risk factors (other drugs and/or medical conditions).Postmarketing reports and pharmacokinetic and electrophysiological data provided evidence that cisapride is associated with the occurrence of QT prolongation and torsades de pointes. The risk of fatal arrhythmia with cisapride was believed to outweigh the benefit for the approved indication, treatment of nocturnal heartburn due to gastroesophageal reflux disease, leading to the drug's discontinuation in the United States. JF - The American journal of gastroenterology AU - Wysowski, D K AU - Corken, A AU - Gallo-Torres, H AU - Talarico, L AU - Rodriguez, E M AD - Office of Post-Marketing Drug Risk Assessment, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA. Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 1698 EP - 1703 VL - 96 IS - 6 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Adverse Drug Reaction Reporting Systems KW - *Arrhythmias, Cardiac: chemically induced KW - *Cisapride: adverse effects KW - Cisapride: contraindications KW - *Drug and Narcotic Control KW - Female KW - *Gastrointestinal Agents: adverse effects KW - Gastrointestinal Agents: contraindications KW - Humans KW - Male KW - *Product Surveillance, Postmarketing KW - Risk Factors KW - Tachycardia, Ventricular: chemically induced KW - Time Factors KW - Torsades de Pointes: chemically induced KW - United States KW - *United States Food and Drug Administration KW - Ventricular Fibrillation: chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85349389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Postmarketing+reports+of+QT+prolongation+and+ventricular+arrhythmia+in+association+with+cisapride+and+Food+and+Drug+Administration+regulatory+actions.&rft.au=Wysowski%2C+D+K%3BCorken%2C+A%3BGallo-Torres%2C+H%3BTalarico%2C+L%3BRodriguez%2C+E+M&rft.aulast=Wysowski&rft.aufirst=D&rft.date=2001-06-01&rft.volume=96&rft.issue=6&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The epidemiology of fatalities reported to the vaccine adverse event reporting system 1990-1997. AN - 72331363; 11760487 AB - To examine the fatalities reported to the federally administered Vaccine Adverse Event Reporting System (VAERS), a passive surveillance system, in its first 7 years. The working data set included variables such as demographic information, dates of vaccination, adverse event onset and death, vaccines administered, and vaccination facility data. Frequencies for these data and state reporting rates were calculated. A total of 1266 fatalities were reported to VAERS during July 1990 through June 1997. The number of death reports peaked in 1992-1993 and then declined. The overall median age of cases was 0.4 years, with a range of 1 day to 104 years. Nearly half of the deaths were attributed to sudden infant death syndrome (SIDS). The trend of decreasing numbers of deaths reported to VAERS since 1992-1993 follows that observed for SIDS overall for the US general population following implementation of the 'Back to Sleep' program. These data may support findings of past controlled studies showing that the association between infant vaccination and SIDS is coincidental and not causal. VAERS reports of death after vaccination may be stimulated by the temporal association, rather than by any causal relationship. JF - Pharmacoepidemiology and drug safety AU - Silvers, L E AU - Ellenberg, S S AU - Wise, R P AU - Varricchio, F E AU - Mootrey, G T AU - Salive, M E AD - US Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Bethesda, MD, USA. lsilvers@cvm.fda.gov PY - 2001 SP - 279 EP - 285 VL - 10 IS - 4 SN - 1053-8569, 1053-8569 KW - Vaccines KW - 0 KW - Index Medicus KW - Health Facilities KW - Age Factors KW - Sudden Infant Death -- epidemiology KW - Sex Factors KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - United States Food and Drug Administration KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Vaccines -- adverse effects KW - Vaccination -- mortality KW - Adverse Drug Reaction Reporting Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72331363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=The+epidemiology+of+fatalities+reported+to+the+vaccine+adverse+event+reporting+system+1990-1997.&rft.au=Silvers%2C+L+E%3BEllenberg%2C+S+S%3BWise%2C+R+P%3BVarricchio%2C+F+E%3BMootrey%2C+G+T%3BSalive%2C+M+E&rft.aulast=Silvers&rft.aufirst=L&rft.date=2001-06-01&rft.volume=10&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-13 N1 - Date created - 2001-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular mechanisms of metal toxicity and carcinogenesis. AN - 72226808; 11678608 AB - Many metals and metal-containing compounds have been identified to be potent mutagens and carcinogens. Recently, a new sub-discipline of molecular toxicology and carcinogenesis has been developed. The combination of newly developed molecular techniques and free radical approach makes it possible to insightfully examine metal-induced carcinogenesis in precise molecular terms so that intricate biological interrelationships can be elucidated. In consideration of the increased amount of new findings deciphered by utilizing these new methods, the 1st Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held. In this conference, more than 50 scientists from nine countries presented their novel discoveries concerning metal-induced carcinogenesis, delineated molecular mechanism of metal carcinogenesis, and proposed novel therapeutic intervention and prevention strategies. This article reviews some of the state-of-the-art information presented at the meeting regarding the molecular mechanisms of metal cytotoxicity and carcinogenesis. JF - Molecular and cellular biochemistry AU - Wang, S AU - Shi, X AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 3 EP - 9 VL - 222 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Carcinogens KW - 0 KW - Metals KW - Reactive Oxygen Species KW - Transcription Factors KW - Index Medicus KW - Gene Expression -- drug effects KW - Transcription Factors -- physiology KW - Reactive Oxygen Species -- metabolism KW - Mutagenesis -- drug effects KW - Transcription Factors -- drug effects KW - Apoptosis KW - Humans KW - Signal Transduction -- drug effects KW - Cell Division -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Carcinogens -- toxicity KW - Metals -- metabolism KW - Metals -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72226808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Molecular+mechanisms+of+metal+toxicity+and+carcinogenesis.&rft.au=Wang%2C+S%3BShi%2C+X&rft.aulast=Wang&rft.aufirst=S&rft.date=2001-06-01&rft.volume=222&rft.issue=1-2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-27 N1 - Date created - 2001-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methods for projecting long-term dietary exposure from short-term survey data for environmental contaminants. AN - 71368044; 12539862 AB - Public health risk assessments often involve dietary exposures over long periods of time. However, most information about dietary consumption habits comes from short-term surveys that are conducted for periods of three days or less. When employed for characterizing long-term exposures, short-term surveys are likely to underestimate the number of persons consuming a particular food, while overestimating the amount consumed by each individual. Direct application of short-term data is particularly misleading for foods that are consumed infrequently. If a more accurate population estimate for chronic dietary intake is needed for a risk assessment, then two general techniques may be considered. The first method is simpler, while the second is more accurate. Both methods require information about the size of the population consuming the food over the long-term period. The simpler fractional adjustment method reduces consumption across the entire distribution by the ratio of consumer population sizes. Since this method will tend to underestimate high-end exposures and overestimate low-end exposures, it is most useful as a quick bounding exercise. Since short-term surveys are better at characterizing the behavior of frequent consumers, a second method employs an exponential function to reduce the low end of the population distribution by a greater amount than the high end. If available, additional information may be used to select the parameter values for the exponential adjustment. Otherwise, an uncertainty range may be used for the parameter values. Since the frequency-based method is more complex, it is most valuable when used as part of a chronic exposure simulation. Examples of both methods are given for the estimation of chronic wine consumption. JF - Toxicology and industrial health AU - Carrington, C D AU - Bolger, P M AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA. cdc@cfsan.fda.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 176 EP - 179 VL - 17 IS - 5-10 SN - 0748-2337, 0748-2337 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Public Health KW - Reproducibility of Results KW - Humans KW - Forecasting KW - Data Collection KW - Risk Assessment KW - Environmental Exposure KW - Diet KW - Environmental Pollutants -- adverse effects KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71368044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Methods+for+projecting+long-term+dietary+exposure+from+short-term+survey+data+for+environmental+contaminants.&rft.au=Carrington%2C+C+D%3BBolger%2C+P+M&rft.aulast=Carrington&rft.aufirst=C&rft.date=2001-06-01&rft.volume=17&rft.issue=5-10&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-06 N1 - Date created - 2003-01-23 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Subchronic toxicity of fish oil concentrates in male and female rats. AN - 71198751; 11575575 AB - There are an overwhelming number of reports indicating the beneficial effects of fish oil supplements in human and animal nutrition. The purpose of this study, second in a series, was to evaluate the effects, particularly those that may be harmful, of high-dose, long-term consumption of fish oil concentrates (FOC) using male and female rats. One hundred and twenty male and 120 female rats were gavaged daily with oils and oil mixtures in a volume equal to 0.5% body weight (5 mL/kg/d) for 13 weeks. The administered oils were corn oil, pure menhaden oil (MO), pure MaxEPA fish oil or different mixtures of corn oil with MO. The stability and the homogeneity of the dosing solutions were tested under study conditions. The animals received isocaloric and isonitrogenous diets throughout. Food and pure water were supplied ad libitum. At the end of the in-life phase of the study, the animals were anaesthetized with CO2 and humanely killed by exsanguination. Blood and other tissues were prepared for various clinical, histopathological and laboratory tests. Some beneficial effects of FOC, such as reduction in total serum cholesterol, in rats were confirmed. However, we also observed a significant reduction in absolute amount of serum HDL and a significant increase in relative liver and spleen weights in both sexes with the high dose of FOC. High doses of FOC (5 mL/kg/d) reduced serum iron and vitamin E concentrations. A reduction in osmotic fragility of RBC as well as an increase in RBC deformity were also observed in rats treated with high doses of FOC. These rats showed a significant overall increase in WBC count. We conclude that in rats, subchronic consumption of high levels of FOC can be beneficial but may also be harmful because of induction of clinical abnormalities including increased red cell deformity, increased relative liver and spleen weights, and reduced serum HDL, iron and vitamin E concentrations. JF - Journal of nutritional science and vitaminology AU - Rabbani, P I AU - Alam, H Z AU - Chirtel, S J AU - Duvall, R E AU - Jackson, R C AU - Ruffin, G AD - Risk Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 201 EP - 212 VL - 47 IS - 3 SN - 0301-4800, 0301-4800 KW - Cholesterol, HDL KW - 0 KW - Dietary Fats, Unsaturated KW - Fatty Acids, Omega-3 KW - Fish Oils KW - Vitamin E KW - 1406-18-4 KW - Menhaden oil KW - 1D8HWC57D0 KW - Corn Oil KW - 8001-30-7 KW - Cholesterol KW - 97C5T2UQ7J KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Dietary Supplements -- toxicity KW - Erythrocytes KW - Iron -- blood KW - Vitamin E -- blood KW - Rats KW - Cholesterol -- blood KW - Rats, Sprague-Dawley KW - Cholesterol, HDL -- blood KW - Corn Oil -- toxicity KW - Female KW - Male KW - Organ Size -- drug effects KW - Dietary Fats, Unsaturated -- toxicity KW - Fish Oils -- toxicity KW - Fatty Acids, Omega-3 -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71198751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nutritional+science+and+vitaminology&rft.atitle=Subchronic+toxicity+of+fish+oil+concentrates+in+male+and+female+rats.&rft.au=Rabbani%2C+P+I%3BAlam%2C+H+Z%3BChirtel%2C+S+J%3BDuvall%2C+R+E%3BJackson%2C+R+C%3BRuffin%2C+G&rft.aulast=Rabbani&rft.aufirst=P&rft.date=2001-06-01&rft.volume=47&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Journal+of+nutritional+science+and+vitaminology&rft.issn=03014800&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-13 N1 - Date created - 2001-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles. AN - 71066020; 11469723 AB - The CYP1A1 gene encodes microsomal cytochrome P4501A1 that catalyzes the metabolism of many xenobiotics, including the oxygenation of polycyclic aromatic hydrocarbons (PAH). Induction of CYP1A1 enhances the metabolism of PAHs, and therefore, represents an adaptive response to chemical exposure in mammalian cells. Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene. The AhR mediated transcription is tightly regulated through, at least, two mechanisms: (a) the cytoplasmic AhR interacts with hsp90 and an immunophilin chaperone AIP for proper folding and receptivity, and (b) the agonist-activated, nuclear AhR is degraded through the ubiquitin-26S proteasome mediated protein turnover, such that the transcription by AhR is controlled at a physiologically adequate level. In addition to CYP1A1 induction, AhR mediates a broad range of biological responses to CYP1A1 inducers, typified by the environmental contaminant dioxin, via modulating gene expression. Thus, mechanistic studies of CYP1A1 induction have provided insights into P450 induction, PAH carcinogenesis, dioxin action, AhR function, and receptor-mediated mammalian gene expression. JF - Current drug metabolism AU - Ma, Q AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 149 EP - 164 VL - 2 IS - 2 SN - 1389-2002, 1389-2002 KW - AHRR protein, human KW - 0 KW - Basic Helix-Loop-Helix Transcription Factors KW - Receptors, Aryl Hydrocarbon KW - Repressor Proteins KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Signal Transduction -- physiology KW - Regulatory Sequences, Nucleic Acid KW - Animals KW - Humans KW - Enzyme Induction KW - Transcription, Genetic KW - Models, Biological KW - Cytochrome P-450 CYP1A1 -- genetics KW - Repressor Proteins -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Receptors, Aryl Hydrocarbon -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71066020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+metabolism&rft.atitle=Induction+of+CYP1A1.+The+AhR%2FDRE+paradigm%3A+transcription%2C+receptor+regulation%2C+and+expanding+biological+roles.&rft.au=Ma%2C+Q&rft.aulast=Ma&rft.aufirst=Q&rft.date=2001-06-01&rft.volume=2&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Current+drug+metabolism&rft.issn=13892002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts. AN - 71063203; 11462792 AB - Oxidative stress, reactive oxygen (ROS), and nitrogen (RNS) species have been known to be involved in a multitude of neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Both ROS and RNS have very short half-lives, thereby making their identification very difficult as a specific cause of neurodegeneration. Recently, we have developed a high performance liquid chromatography/electrochemical detection (HPLC/EC) method to identify 3-nitrotyrosine (3-NT), an in vitro and in vivo biomarker of peroxynitrite production, in cell cultures and brain to evaluate if an agent-driven neurotoxicity is produced by the generation of peroxynitrite. We show that a single or multiple injections of methamphetamine (METH) produced a significant increase in the formation of 3-NT in the striatum. This formation of 3-NT correlated with the striatal dopamine depletion caused by METH administration. We also show that PC12 cells treated with METH has significantly increased formation of 3-NT and dopamine depletion. Furthermore, we report that pretreatment with antioxidants such as selenium and melatonin can completely protect against the formation of 3-NT and depletion of striatal dopamine. We also report that pretreatment with peroxynitrite decomposition catalysts such as 5, 10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato iron III (FeTMPyP) and 5, 10, 15, 20-tetrakis (2,4,6-trimethyl-3,5-sulfonatophenyl) porphinato iron III (FETPPS) significantly protect against METH-induced 3-NT formation and striatal dopamine depletion. We used two different approaches, pharmacological manipulation and transgenic animal models, in order to further investigate the role of peroxynitrite. We show that a selective neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI), significantly protect against the formation of 3-NT as well as striatal dopamine depletion. Similar results were observed with nNOS knockout and copper zinc superoxide dismutase (CuZnSOD)-overexpressed transgenic mice models. Finally, using the protein data bank crystal structure of tyrosine hydroxylase, we postulate the possible nitration of specific tyrosine moiety in the enzyme that can be responsible for dopaminergic neurotoxicity. Together, these data clearly support the hypothesis that the reactive nitrogen species, peroxynitrite, plays a major role in METH-induced dopaminergic neurotoxicity and that selective antioxidants and peroxynitrite decomposition catalysts can protect against METH-induced neurotoxicity. These antioxidants and decomposition catalysts may have therapeutic potential in the treatment of psychostimulant addictions. JF - Annals of the New York Academy of Sciences AU - Imam, S Z AU - el-Yazal, J AU - Newport, G D AU - Itzhak, Y AU - Cadet, J L AU - Slikker, W AU - Ali, S F AD - Neurochemistry Laboratory Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Rd., Jefferson, AR 72079, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 366 EP - 380 VL - 939 SN - 0077-8923, 0077-8923 KW - Antioxidants KW - 0 KW - Biomarkers KW - Dopamine Agents KW - Enzyme Inhibitors KW - Indazoles KW - Nitrates KW - peroxynitric acid KW - 26404-66-0 KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Methamphetamine KW - 44RAL3456C KW - NOS1 protein, human KW - EC 1.14.13.39 KW - Nitric Oxide Synthase KW - Nitric Oxide Synthase Type I KW - Nos1 protein, rat KW - 7-nitroindazole KW - UX0N37CMVH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Antioxidants -- pharmacology KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Humans KW - Biomarkers -- analysis KW - Indazoles -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Nitric Oxide Synthase -- metabolism KW - PC12 Cells KW - Dopamine Agents -- toxicity KW - Nitrates -- metabolism KW - Dopamine -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- drug effects KW - Tyrosine -- analogs & derivatives KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71063203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Methamphetamine-induced+dopaminergic+neurotoxicity%3A+role+of+peroxynitrite+and+neuroprotective+role+of+antioxidants+and+peroxynitrite+decomposition+catalysts.&rft.au=Imam%2C+S+Z%3Bel-Yazal%2C+J%3BNewport%2C+G+D%3BItzhak%2C+Y%3BCadet%2C+J+L%3BSlikker%2C+W%3BAli%2C+S+F&rft.aulast=Imam&rft.aufirst=S&rft.date=2001-06-01&rft.volume=939&rft.issue=&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biomarkers of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction as indicators of neuroprotection. AN - 71021978; 11462793 AB - In humans or animals, symptoms of mitochondrial energy dysfunction may be produced by mutations or inborn errors of the necessary enzymes, as well as by enzyme inhibitors or uncouplers of the oxidative phosphorylation process. 3-Nitropropionic acid (3-NPA) is a toxin that is sometimes produced on moldy crops (sugarcane, peanuts, etc.) in amounts sufficient to cause severe neuromuscular disorders when consumed by humans. In vitro, 3-NPA irreversibly inactivates SDH, a Complex II respiratory enzyme important for mitochondrial energy production. We have been studying biomarkers of 3-NPA exposure in the expectation that such markers may be useful in the screening process to identify neuroprotective agents against neurotoxicity produced by mitochondrial energy dysfunction. Animals were sacrificed at various times after 3-NPA exposure for histochemical visualization of SDH activity and measurement of immediate postmortem rectal temperature. 3-NPA-treated rats experienced progressive hypothermia that reached a loss of 3 degrees C or more in core body temperature by three hours after dosing. The optical density of the SDH stain in brain was reduced, following a similar time course, most prominently in the cerebellum and least sharply in the thalamus. Some rats were given injections of L-carnitine (an enhancer of fatty acid transport) either alone, or as a pretreatment prior to a dose of 3-NPA. Although L-carnitine deficiency by itself can produce mitochondrial dysfunction, pretreatment with L-carnitine was of limited efficacy at overcoming the effects of 3-NPA on either body temperature or quantitative SDH histochemistry. Body temperature and SDH histochemistry may be useful biomarkers for evaluating the efficacy of neuroprotective agents against lower doses of 3-NPA, against other pharmacological models of mitochondrial dysfunction, or even against genetic mitochondrial diseases. JF - Annals of the New York Academy of Sciences AU - Scallet, A C AU - Nony, P L AU - Rountree, R L AU - Binienda, Z K AD - Division of Neurotoxicology, National Center for Toxicological Research, USFDA, 3900 NCTR Drive, Jefferson, Arkansas 72079, USA. AScallet@NCTR.FDA.GOV Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 381 EP - 392 VL - 939 SN - 0077-8923, 0077-8923 KW - Biomarkers KW - 0 KW - Convulsants KW - Nitro Compounds KW - Propionates KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Mitochondrial Myopathies -- enzymology KW - Biomarkers -- analysis KW - Male KW - Brain -- enzymology KW - Succinate Dehydrogenase -- drug effects KW - Body Temperature -- drug effects KW - Convulsants -- pharmacology KW - Brain -- drug effects KW - Propionates -- pharmacology KW - Body Temperature -- physiology KW - Succinate Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71021978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Biomarkers+of+3-nitropropionic+acid+%283-NPA%29-induced+mitochondrial+dysfunction+as+indicators+of+neuroprotection.&rft.au=Scallet%2C+A+C%3BNony%2C+P+L%3BRountree%2C+R+L%3BBinienda%2C+Z+K&rft.aulast=Scallet&rft.aufirst=A&rft.date=2001-06-01&rft.volume=939&rft.issue=&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of L-carnitine pretreatment on 3-nitropropionic acid-induced inhibition of rat brain succinate dehydrogenase activity. AN - 71021183; 11462791 AB - L-Carnitine (LC) plays an important regulatory role in the mitochondrial transport of long chain free fatty acids (FFA). 3-Nitropropionic acid (3-NPA) is known to induce cellular energy deficit and oxidative stress-related neurotoxicity via an irreversible inhibition of mitochondrial succinate dehydrogenase (SDH). In the present study, activity of SDH was measured in order to evaluate neuroprotective effects of LC against the 3-NPA-induced neurotoxicity. Male, CD Sprague-Dawley rats, three months old, were injected with either 50 or 100 mg/kg of LC, i.p., 30 min prior to 3-NPA (30 mg/kg, s.c.) or with 3-NPA alone. The activity of brain SDH was quantified spectrophotometrically in caudate nucleus (CN), frontal cortex (FC), and hippocampus (HIP) 60 min after the 3-NPA injection. The SDH activity in the animals treated with 3-NPA alone was 38% (CN), 50% (FC), and 36% (HIP) that of saline controls. Pretreatment with LC prior to 3-NPA injection attenuated decreases of SDH activity by approximately 15 and 29% (LC low and high dose, respectively). Despite the attenuation of SDH inhibition, the activity of SDH in these regions remained significantly lower in treated than in control rats (p < 0.05). It appears that the protective effect of LC against 3-NPA-induced oxidative stress cannot be explained by the direct action of LC to interfere with the SDH inhibition but are rather achieved by LC actions downstream of the SDH inhibition. JF - Annals of the New York Academy of Sciences AU - Binienda, Z K AU - Sadovova, N V AU - Rountree, R L AU - Scallet, A C AU - Ali, S F AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, FDA/NCTR, Jefferson, AR 72079-9502, USA. zbinienda@nctr.fda.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 359 EP - 365 VL - 939 SN - 0077-8923, 0077-8923 KW - Convulsants KW - 0 KW - Nitro Compounds KW - Propionates KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Caudate Nucleus -- enzymology KW - Frontal Lobe -- drug effects KW - Frontal Lobe -- enzymology KW - Caudate Nucleus -- drug effects KW - Hippocampus -- enzymology KW - Male KW - Hippocampus -- drug effects KW - Succinate Dehydrogenase -- drug effects KW - Propionates -- toxicity KW - Mitochondria -- enzymology KW - Carnitine -- pharmacology KW - Mitochondria -- drug effects KW - Succinate Dehydrogenase -- metabolism KW - Convulsants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71021183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Effect+of+L-carnitine+pretreatment+on+3-nitropropionic+acid-induced+inhibition+of+rat+brain+succinate+dehydrogenase+activity.&rft.au=Binienda%2C+Z+K%3BSadovova%2C+N+V%3BRountree%2C+R+L%3BScallet%2C+A+C%3BAli%2C+S+F&rft.aulast=Binienda&rft.aufirst=Z&rft.date=2001-06-01&rft.volume=939&rft.issue=&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Iron and folate in fortified cereals. AN - 70989774; 11444421 AB - Fortification of cereal-grain products was introduced in 1941 when iron and three vitamins were added to flour and bread. Ready-to-eat cereals were fortified at about the same time. These fortifications have contributed to increased dietary iron intake and reductions in iron deficiency anemia in the US. In 1996, FDA finalized rules for fortification of specific enriched cereal-grain products with folic acid. This measure was instituted to increase the folate intakes of women of child-bearing age and thereby reduce the risk of having a pregnancy affected with a neural tube birth defect. However, with recent increases in fortification, public health officials in the US are concemed that excess intake of specific nutrients such as iron and folic acid may result in toxic manifestations. Our objective was to measure iron and total folate content in breakfast cereals and compare assay to label values for % Daily Value. We also determined by weight the amount of a ready-to-eat breakfast cereal adults would eat and compared this to the labeled serving size, for which the reference amount for this cereal per eating occasion was 1 cup or 30 g. Twenty-nine breakfast cereals were analyzed for iron content using the bathophenanthroline reaction. Twenty-eight cereals were analyzed for total folate, utilizing a microbiological assay with tri-enzyme digestion. Serving size quantities were estimated in seventy-two adults who regularly ate breakfast cereal and were asked to fill a 16 or 22 cm round bowl with the amount of cereal that they would consume for breakfast. When the labeled value was compared to the assayed value for iron content 21 of the 29 breakfast cereals were 120% or more of the label value and 8 cereals were 150% or more of the label value. Overall, analyzed values for iron ranged from 80% to 190% of label values. Analyzed values for folate ranged from 98% to 320% of label values. For 14 of 28 cereals, analyzed values exceeded label declarations by more than 150%. Bran-containing cereals contained the highest amounts of folate relative to their label declarations. The median analyzed serving size for the breakfast cereal was 47 g for females, 61 g for males with a combined median of 56 g as compared to the label value of 30 g. Analyzed values of iron and folic acid in breakfast cereals were considerably higher than labeled values. For adults, the amount of cereal actually consumed was approximately 200% of the labeled serving size. When the quantity of cereal consumed is more than the labeled serving size and when the levels of iron and folate are higher than declared, the intake of both will be significantly greater than the labeled values. It will be important to continue monitoring serum ferritin and folate levels in NHANES IV, since daily consumption of breakfast cereals may contribute to excessive intakes of iron and folate. JF - Journal of the American College of Nutrition AU - Whittaker, P AU - Tufaro, P R AU - Rader, J I AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. paul.whittaker@cfsan.fda.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 247 EP - 254 VL - 20 IS - 3 SN - 0731-5724, 0731-5724 KW - Folic Acid KW - 935E97BOY8 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - United States KW - Nutritional Requirements KW - Food Labeling KW - Humans KW - Nutrition Policy KW - Male KW - Female KW - Iron -- analysis KW - Iron -- administration & dosage KW - Iron -- adverse effects KW - Edible Grain -- chemistry KW - Food, Fortified -- analysis KW - Folic Acid -- analysis KW - Folic Acid -- adverse effects KW - Folic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70989774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Nutrition&rft.atitle=Iron+and+folate+in+fortified+cereals.&rft.au=Whittaker%2C+P%3BTufaro%2C+P+R%3BRader%2C+J+I&rft.aulast=Whittaker&rft.aufirst=P&rft.date=2001-06-01&rft.volume=20&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Nutrition&rft.issn=07315724&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Computer resources for planning and responding to chemical emergencies. AN - 70968853; 11414512 JF - Applied occupational and environmental hygiene AU - Daniels, W J AU - Miller, A AD - US Public Health Service Region VIII, Denver, Colorado 80294, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 645 EP - 648 VL - 16 IS - 6 SN - 1047-322X, 1047-322X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Software KW - Humans KW - User-Computer Interface KW - Decision Support Systems, Management KW - Disaster Planning -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70968853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Computer+resources+for+planning+and+responding+to+chemical+emergencies.&rft.au=Daniels%2C+W+J%3BMiller%2C+A&rft.aulast=Daniels&rft.aufirst=W&rft.date=2001-06-01&rft.volume=16&rft.issue=6&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to protein aeroallergens in egg processing facilities. AN - 70943213; 11414516 AB - Proteinaceous materials in the air can be highly allergenic and result in a range of immunologically mediated respiratory effects, including asthma. We report on the largest evaluation of exposure to date of airborne egg protein concentrations in an egg breaking and processing plant that had cases of occupational asthma. Personal air samples for egg protein were analyzed in duplicate on each PTFE filter using two analytical methods: (1) a commercial assay for non-specific total protein, and (2) indirect competitive inhibition assay using an ELISA method to quantify specific egg protein components. The highest concentrations were found in the egg washing room (mean exposure 644 microg/m3) and breaking room (255 microg/m3), which were also the areas where the risk of being sensitized was the greatest. There was excellent quantitative agreement between the airborne concentrations of total protein and sum of the specific protein antigens (ovalbumin, ovomucoid, and lysozyme). The correlation coefficient of the log-transformed data from the two methods was 0.88 (p < 0.0001). Size-selective sampling also indicated that most of the aerosol was capable of reaching the small airways. The methods described can be utilized to evaluate employee exposure to egg proteins. Exposure documentation, coupled with recommended exposure reduction strategies, could facilitate prevention of future employee sensitization and allergic respiratory responses by identifying high-exposure jobs and evaluating control measures. JF - Applied occupational and environmental hygiene AU - Boeniger, M F AU - Lummus, Z L AU - Biagini, R E AU - Bernstein, D I AU - Swanson, M C AU - Reed, C AU - Massoudi, M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 660 EP - 670 VL - 16 IS - 6 SN - 1047-322X, 1047-322X KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Egg Proteins, Dietary KW - Index Medicus KW - Reference Values KW - Immunoassay -- methods KW - Photomicrography KW - Humans KW - Task Performance and Analysis KW - Asthma -- etiology KW - Egg Proteins, Dietary -- analysis KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Asthma -- prevention & control KW - Food-Processing Industry KW - Environmental Monitoring -- methods KW - Egg Proteins, Dietary -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70943213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Exposure+to+protein+aeroallergens+in+egg+processing+facilities.&rft.au=Boeniger%2C+M+F%3BLummus%2C+Z+L%3BBiagini%2C+R+E%3BBernstein%2C+D+I%3BSwanson%2C+M+C%3BReed%2C+C%3BMassoudi%2C+M&rft.aulast=Boeniger&rft.aufirst=M&rft.date=2001-06-01&rft.volume=16&rft.issue=6&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposures of workers at a magazine printing company. AN - 70941844; 11414511 JF - Applied occupational and environmental hygiene AU - Cook, C AU - Page, E AD - Division of Surveillance, Hazard Evaluations and Field Studies of NIOSH, Cincinnati, Ohio 45226, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 639 EP - 644 VL - 16 IS - 6 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Solvents KW - Index Medicus KW - Air Pollutants, Occupational -- analysis KW - Humans KW - Air Pollutants, Occupational -- adverse effects KW - Middle Aged KW - Organizational Case Studies KW - Occupational Exposure -- prevention & control KW - Dermatitis, Occupational -- etiology KW - Ink KW - Solvents -- analysis KW - Solvents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Asthma -- chemically induced KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70941844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Exposures+of+workers+at+a+magazine+printing+company.&rft.au=Cook%2C+C%3BPage%2C+E&rft.aulast=Cook&rft.aufirst=C&rft.date=2001-06-01&rft.volume=16&rft.issue=6&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - UV doses of Americans. AN - 70941082; 11421067 AB - The UV doses of Americans were never measured, but are needed for assessing the risks of UV-related health effects. We calculated these doses using a novel approach. The Environmental Protection Agency's (EPA) National Human Activity Pattern Survey (NHAPS) recorded the activity profiles of 9386 Americans over 24 months to assess their exposure to environmental pollutants, one of which is UV radiation. NHAPS used randomized telephone interviews to get their previous day's minute-by-minute activities. From NHAPS we extracted only the outdoor-daylight data of the northern and southern indoor workers (95%), stratifying by season, sex and age (0-21, 22-40, 41-59 and 60+ years) to find the average time Americans spend outdoors. Knowing the total daylight time and that while outdoors Americans are exposed to about 30% of the available solar UV (on a horizontal plane), we calculated their percent ambients. The average American's percent ambients are 2.6 and 2.5% for northern and southern females, respectively, and 3.5 and 3.6% for northern and southern males, respectively. Men over 40 years of age have the highest ambients (4%). From their ambients we calculated their annual doses using seasonal averages of UV measurements taken daily for over 2 years by EPA Brewer spectrophotometers located in four quadrants of the United States: Atlanta, GA; Boston, MA; Bozeman, MT and Riverside, CA. The average erythemal UV doses of Americans are about 25,000 J/m2/year, 22,000 for females and 28,000 for males, or 33,000 J/m2/year including a conservative continental U.S. vacation (7800 J/m2). Thus, we can now assess the risks of UV-related health effects for Americans. JF - Photochemistry and photobiology AU - Godar, D E AU - Wengraitis, S P AU - Shreffler, J AU - Sliney, D H AD - US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852, USA. deg@cdrh.fda.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 621 EP - 629 VL - 73 IS - 6 SN - 0031-8655, 0031-8655 KW - Index Medicus KW - United States KW - Radiation Dosage KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Risk Assessment KW - Child, Preschool KW - Infant KW - Adult KW - Data Collection KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Ultraviolet Rays -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70941082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=UV+doses+of+Americans.&rft.au=Godar%2C+D+E%3BWengraitis%2C+S+P%3BShreffler%2C+J%3BSliney%2C+D+H&rft.aulast=Godar&rft.aufirst=D&rft.date=2001-06-01&rft.volume=73&rft.issue=6&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. AN - 70936614; 11410481 AB - Gemtuzumab ozogamicin (Mylotarg; Wyeth Laboratories, Philadelphia, PA) consists of a semisynthetic derivative of calicheamicin, a cytotoxic antibiotic linked to a recombinant monoclonal antibody directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). In this study, we review the preclinical and clinical profiles of this immunoconjugate and the regulatory review that led to marketing approval by the United States Food and Drug Administration. From the literature and manufacturer's data, we review the activity, tolerability, and pharmacokinetics of gemtuzumab ozogamicin in preclinical and Phase I studies and its activity, efficacy, and side effects in three Phase 2 trials of 142 patients with relapsed AML. In Phase I studies, the major toxicity was myelosuppression, especially neutropenia and thrombocytopenia, resulting from the expression of CD33 on myeloid progenitor cells. The Phase 2 dose was 9 mg/m(2) infused i.v. over 4 h, repeated on day 14. A minority of patients experienced acute infusion-related symptoms, usually transient and occasionally requiring hospitalization. The complete response (CR) rate with full recovery of hematopoiesis was 16%. A subset of patients [CRs with incomplete platelet recovery (CRps)] was identified with blast clearance and neutrophil recovery but incomplete platelet recovery. The duration of responses of CRps appeared to be similar to those of the CRs, although the numbers were small. The question of the equivalence of these response groups was a central issue in the review of this new drug application (NDA). After considerable discussion, the Oncology Drugs Advisory Committee recommended allowing inclusion of CRps resulting in an overall response rate in the Phase 2 studies of 30%. In the subgroup of patients over 60 years of age, the overall response rate was 26%. Response duration was difficult to establish because of the high prevalence of postremission therapies. Tolerability and ease of administration may be improved compared with conventional chemotherapy, except for hepatotoxicity, with 31% of patients exhibiting abnormal liver enzymes. One patient died of liver failure in the Phase 2 trials. Marketing approval of gemtuzumab ozogamicin was granted on May 17, 2000 by the United States Food and Drug Administration under the Accelerated Approval regulations. Gemtuzumab ozogamicin is indicated for the treatment of patients with CD33 positive AML in first relapse who are 60 years of age or older and who are not considered candidates for cytotoxic chemotherapy. The approved dose was 9 mg/m(2) i.v. over 4 h and repeated in 14 days. Completion of the ongoing studies of gemtuzumab ozogamicin in relapsed AML and initiation of randomized clinical trials comparing the effects of gemtuzumab ozogamicin in combination with conventional induction chemotherapy to conventional chemotherapy alone on survival are mandated to confirm clinical benefit under the accelerated approval Subpart H regulations. Postmarketing reports of fatal anaphylaxis, adult respiratory distress syndrome (ARDS), and hepatotoxicity, especially venoocclusive disease (VOD) in patients treated with gemtuzumab ozogamicin, with and without associated hematopoietic stem cell transplantation (HSCT), have required labeling revisions and the initiation of a registration surveillance program. Tumor lysis and ARDS have been reported in patients with leukocytes above 30,000/ml treated with gemtuzumab ozogamicin; therefore, the reduction of leukocyte counts to below 30,000/ml is recommended prior to treatment. Patients should be carefully monitored for acute hypersensitivity, hypoxia, and delayed hepatotoxicity following treatment with gemtuzumab ozogamicin. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Bross, P F AU - Beitz, J AU - Chen, G AU - Chen, X H AU - Duffy, E AU - Kieffer, L AU - Roy, S AU - Sridhara, R AU - Rahman, A AU - Williams, G AU - Pazdur, R AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA. brossp@cder.fda.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 1490 EP - 1496 VL - 7 IS - 6 SN - 1078-0432, 1078-0432 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Immunotoxins KW - gemtuzumab KW - 93NS566KF7 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Models, Chemical KW - Middle Aged KW - Adolescent KW - Time Factors KW - Recurrence KW - Male KW - Female KW - Immunotoxins -- pharmacokinetics KW - Anti-Bacterial Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacokinetics KW - Anti-Bacterial Agents -- adverse effects KW - Immunotoxins -- adverse effects KW - Anti-Bacterial Agents -- pharmacokinetics KW - Antibodies, Monoclonal -- therapeutic use KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- pharmacokinetics KW - Immunotoxins -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Leukemia, Myeloid, Acute -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70936614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Approval+summary%3A+gemtuzumab+ozogamicin+in+relapsed+acute+myeloid+leukemia.&rft.au=Bross%2C+P+F%3BBeitz%2C+J%3BChen%2C+G%3BChen%2C+X+H%3BDuffy%2C+E%3BKieffer%2C+L%3BRoy%2C+S%3BSridhara%2C+R%3BRahman%2C+A%3BWilliams%2C+G%3BPazdur%2C+R&rft.aulast=Bross&rft.aufirst=P&rft.date=2001-06-01&rft.volume=7&rft.issue=6&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-20 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Clin Cancer Res 2002 Jan;8(1):300 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of sampling and analytical methods for concerted determination of commonly used chloroacetanilide, chlorotriazine, and 2,4-D herbicides in hand-wash, dermal-patch, and air samples. AN - 70932795; 11414520 AB - Sampling and analytical methods were developed for commonly used chloroacetanilide, chlorotriazine, and 2,4-D herbicides in hand washes, on dermal patches, and in air. Eight herbicides selected for study were alachlor, atrazine, cyanazine, 2,4-dichlorophenoxyacetic acid (2,4-D), metolachlor, simazine, and two esters of 2,4-D, the 2-butoxyethyl ester (2,4-D, BE) and the 2-ethylhexyl ester (2,4-D, EH). The hand-wash method consisted of shaking the worker's hand in 150 mL of isopropanol in a polyethylene bag for 30 seconds. The dermal-patch method entailed attaching a 10-cm x 10-cm x 0.6-cm polyurethane foam (PUF) patch to the worker for exposure; recovery of the herbicides was achieved by extraction with 40 mL of isopropanol. The air method involved sampling with an OVS-2 tube (which contained an 11-mm quartz fiber filter and two beds of XAD-2 resin) and recovery with 2 mL of 10:90 methanol:methyl t-butyl ether. Analysis of each of the three sample types was performed by gas chromatography with an electron-capture detector. Diazomethane in solution was employed to convert 2,4-D as the free acid to the methyl ester in each of the three methods for ease of gas chromatography. Silicic acid was added to sample solutions to quench excess diazomethane. Limits of detection for all eight herbicides were matrix-dependent and, generally, less than 1 microgram per sample for each matrix. Sampling and analytical methods met NIOSH evaluation criteria for all herbicides in hand-wash samples, for seven herbicides in air samples (all herbicides except cyanazine), and for six herbicides in dermal-patch samples (all herbicides except cyanazine and 2,4-D). Speciation of 2,4-D esters and simultaneous determination of 2,4-D acid were possible without losses of the esters or of other herbicides (acetanilides and triazines) being determined. JF - Applied occupational and environmental hygiene AU - Tucker, S P AU - Reynolds, J M AU - Wickman, D C AU - Hines, C J AU - Perkins, J B AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 698 EP - 707 VL - 16 IS - 6 SN - 1047-322X, 1047-322X KW - Acetamides KW - 0 KW - Herbicides KW - Triazines KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - 2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)acetamide KW - 78194-29-3 KW - Index Medicus KW - Sensitivity and Specificity KW - 2,4-Dichlorophenoxyacetic Acid -- analysis KW - Chromatography, Gas KW - Acetamides -- analysis KW - Humans KW - Skin KW - Inhalation Exposure -- analysis KW - Herbicides -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70932795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Development+of+sampling+and+analytical+methods+for+concerted+determination+of+commonly+used+chloroacetanilide%2C+chlorotriazine%2C+and+2%2C4-D+herbicides+in+hand-wash%2C+dermal-patch%2C+and+air+samples.&rft.au=Tucker%2C+S+P%3BReynolds%2C+J+M%3BWickman%2C+D+C%3BHines%2C+C+J%3BPerkins%2C+J+B&rft.aulast=Tucker&rft.aufirst=S&rft.date=2001-06-01&rft.volume=16&rft.issue=6&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulatory action criteria for filth and other extraneous materials v. strategy for evaluating hazardous and nonhazardous filth. AN - 70928504; 11407939 AB - The U.S. Food and Drug Administration (FDA) uses regulatory action criteria for filth and extraneous materials to evaluate adulteration of food products. The criteria are organized into three categories: health hazards, indicators of insanitation, and natural or unavoidable defects. The health hazard category includes criteria for physical, chemical, and microbiological hazards associated with filth and extraneous materials. The health hazard category encompasses criteria for HACCP (Hazard Analysis and Critical Control Point) hazards and HACCP contributing factors. The indicators of insanitation category includes criteria for visibly objectionable contaminants, contamination from commensal pests, and other types of contamination that are associated with insanitary conditions in food processing and storage facilities. The natural or unavoidable category includes criteria for harmless, naturally occurring defects and contaminants. A decision tree is presented for the sequential application of regulatory action criteria for filth and extraneous materials associated with each category and with each type of filth or extraneous material in the three categories. This final report of a series in the development of a transparent science base for a revised FDA regulatory policy in the area of filth and extraneous materials in food includes a comprehensive list of the references that form the science base for the FDA regulatory policy. JF - Regulatory toxicology and pharmacology : RTP AU - Olsen, A R AU - Gecan, J S AU - Ziobro, G C AU - Bryce, J R AD - Microanalytical Branch, HFS-315, U.S. Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 363 EP - 392 VL - 33 IS - 3 SN - 0273-2300, 0273-2300 KW - Index Medicus KW - United States KW - Policy Making KW - Reference Values KW - United States Food and Drug Administration KW - Humans KW - Decision Trees KW - Food Handling KW - Risk Assessment KW - Sanitation KW - Public Health KW - Food Contamination -- legislation & jurisprudence KW - Health Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70928504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Regulatory+action+criteria+for+filth+and+other+extraneous+materials+v.+strategy+for+evaluating+hazardous+and+nonhazardous+filth.&rft.au=Olsen%2C+A+R%3BGecan%2C+J+S%3BZiobro%2C+G+C%3BBryce%2C+J+R&rft.aulast=Olsen&rft.aufirst=A&rft.date=2001-06-01&rft.volume=33&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Addressing lesbian, gay, bisexual, and transgender issues from the inside: one federal agency's approach. AN - 70907714; 11392928 AB - The mission of the Substance Abuse and Mental Health Services Administration (SAMHSA) is to protect and serve underserved and vulnerable populations. Congress established SAMHSA under Public Law 102-321 on October 1, 1992, to strengthen the nation's health care capacity to provide prevention, diagnosis, and treatment services for substance abuse and mental illnesses. SAMHSA works in partnership with states, communities, and private organizations to address the needs of people with substance abuse and mental illnesses as well as the community risk factors that contribute to these illnesses. As part of its efforts to address the unique needs of special populations, SAMHSA has reached out to the lesbian, gay, bisexual, and transgender (LGBT) community. SAMHSA and its centers (Center for Substance Abuse Treatment, Center for Substance Abuse Prevention, and Center for Mental Health Services) have made a concerted effort, through both policy and programs, to develop services responsive to this community. JF - American journal of public health AU - Craft, E M AU - Mulvey, K P AD - Substance Abuse and Mental Health Services, Center for Substance Abuse Treatment, Rockwall II, Suite 840, 5600 Fisher Ln, Rockville, MD 20857, USA. ecraft@samhsa.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 889 EP - 891 VL - 91 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Organizational Objectives KW - Needs Assessment KW - Male KW - Female KW - Community Health Planning KW - Quality Assurance, Health Care KW - Substance-Related Disorders -- therapy KW - Prejudice KW - United States Substance Abuse and Mental Health Services Administration -- organization & administration KW - Substance-Related Disorders -- complications KW - Homosexuality KW - United States Substance Abuse and Mental Health Services Administration -- legislation & jurisprudence KW - Transsexualism -- complications KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70907714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Addressing+lesbian%2C+gay%2C+bisexual%2C+and+transgender+issues+from+the+inside%3A+one+federal+agency%27s+approach.&rft.au=Craft%2C+E+M%3BMulvey%2C+K+P&rft.aulast=Craft&rft.aufirst=E&rft.date=2001-06-01&rft.volume=91&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Electromyographic and discomfort analysis of confined-space shipyard welding processes. AN - 70896259; 11394466 AB - This study examined muscle fatigue and discomfort in a confined-space welding operation at a shipyard. Surface electromyography (SEMG) was recorded from seven upper extremity and torso muscles of welders welding in a mock-up of the work environment. Following spectral transform of the SEMG data the percentage of the total signal power in the 10-30 Hz frequency band was compared over time during welding. For the conventional stick electrode welding process (SMAW) several muscles exhibited an increase in the percent of the total signal power in the low-frequency band. Fewer muscles exhibited this fatigue-related spectral density shift with a wire welding process (FCAW) the shipyard has considered adopting. This finding suggests that localized muscle fatigue may be reduced by a change to the wire welding process. Subjectively reported discomfort was generally low for both processes, but confirmed the finding that discomfort in the low back and shoulder regions is experienced in this welding operation. JF - Applied ergonomics AU - Lowe, B D AU - Wurzelbacher, S J AU - Shulman, S A AU - Hudock, S D AD - US Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA. blowe@cdc.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 255 EP - 269 VL - 32 IS - 3 SN - 0003-6870, 0003-6870 KW - Index Medicus KW - Ships KW - Shoulder KW - Humans KW - Neck Pain KW - Adult KW - Electromyography KW - Models, Statistical KW - Back Pain KW - Male KW - Muscle Fatigue KW - Pain -- prevention & control KW - Ergometry KW - Occupational Diseases -- prevention & control KW - Welding UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70896259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+ergonomics&rft.atitle=Electromyographic+and+discomfort+analysis+of+confined-space+shipyard+welding+processes.&rft.au=Lowe%2C+B+D%3BWurzelbacher%2C+S+J%3BShulman%2C+S+A%3BHudock%2C+S+D&rft.aulast=Lowe&rft.aufirst=B&rft.date=2001-06-01&rft.volume=32&rft.issue=3&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Applied+ergonomics&rft.issn=00036870&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Respiratory symptoms among crab processing workers in Alaska: epidemiological and environmental assessment. AN - 70890172; 11385644 AB - Crab processing workers may develop respiratory symptoms and specific IgE responses, but the risk factors have not been fully described. In 1998, 107 workers at a crab processing facility completed a survey both at the beginning and end of the processing season. The surveys included standardized symptom questionnaires, spirometry, and serological testing, as well as measurement of workplace airborne crab allergens and microscopic analysis of aerosolized materials. Over the crab processing season, asthma-like symptoms developed in 26% of study participants and bronchitic symptoms in 19%. Only 9% of those with new asthma-like symptoms were IgE-sensitized to crab at the end of the season. Among the crab processing jobs, butchering and degilling workers had the highest incidence of respiratory symptoms. Both personal and process-related factors appear to affect the development of respiratory symptoms in crab processing workers. In this study, crab specific IgE was not detected in most of the workers with new symptoms. Published 2001 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Ortega, H G AU - Daroowalla, F AU - Petsonk, E L AU - Lewis, D AU - Berardinelli, S AU - Jones, W AU - Kreiss, K AU - Weissman, D N AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia 26505, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 598 EP - 607 VL - 39 IS - 6 SN - 0271-3586, 0271-3586 KW - Allergens KW - 0 KW - Immunoglobulin E KW - 37341-29-0 KW - Index Medicus KW - Animals KW - Chi-Square Distribution KW - Humans KW - Alaska -- epidemiology KW - Food-Processing Industry KW - Longitudinal Studies KW - Risk KW - Cross-Sectional Studies KW - Adult KW - Surveys and Questionnaires KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Allergens -- immunology KW - Asthma -- epidemiology KW - Occupational Diseases -- immunology KW - Immunoglobulin E -- immunology KW - Bronchitis -- immunology KW - Bronchitis -- epidemiology KW - Brachyura KW - Occupational Diseases -- epidemiology KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70890172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Respiratory+symptoms+among+crab+processing+workers+in+Alaska%3A+epidemiological+and+environmental+assessment.&rft.au=Ortega%2C+H+G%3BDaroowalla%2C+F%3BPetsonk%2C+E+L%3BLewis%2C+D%3BBerardinelli%2C+S%3BJones%2C+W%3BKreiss%2C+K%3BWeissman%2C+D+N&rft.aulast=Ortega&rft.aufirst=H&rft.date=2001-06-01&rft.volume=39&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers. AN - 70884567; 11383653 AB - Fescue foot, summer syndrome, reproductive problems, and ryegrass staggers are all diseases of livestock related to endophyte toxins in pasture grasses. Range finding experiments and case studies of fescue foot relative to ergovaline toxin found in endophyte infected tall fescue and lolitrem B present in endophyte infected perennial ryegrass were conducted. Within 42 d of initiating a feeding trial with chopped tall fescue straw containing 825 ppb ergovaline and at environmental temperatures of 15.9 C clinical signs of fescue foot were seen in cattle. Sheep on tall fescue pastures in November consuming feed with 540 ppb ergovaline and at environmental temperatures of 7.8 C developed fescue foot in 21 d while sheep on the adjacent field in the previous 2 mo with environmental temperatures of 16.6 C and 12.8 C and 458 ppb ergovaline in the pasture grasses did not. In a field outbreak of fescue foot affecting 42/425 feeder lambs in November, the ergovaline of sample pasture grasses had a mean concentration of 813 ppb. Perennial ryegrass staggers was seen in 42/237 feeder lambs when mean lolitrem B in the sampled grass was 2,135 ppb. Overgrazing both tall fescue and ryegrass fields increased probability of clinical disease since the highest levels of toxin were found in the crowns and basal leaf sheaths of tall fescue and perennial ryegrass respectively. Based on these findings, ergovaline dietary levels of 400 to 750 ppb to cattle and 500 to 800 ppb to sheep and lolitrem B levels of 1,800 to 2,000 ppb in feed for both species are approximated threshold values for disease. Cold environmental temperatures are equally important to toxin concentrations in precipitating fescue foot disease. JF - Veterinary and human toxicology AU - Tor-Agbidye, J AU - Blythe, L L AU - Craig, A M AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 140 EP - 146 VL - 43 IS - 3 SN - 0145-6296, 0145-6296 KW - Ergotamines KW - 0 KW - Indole Alkaloids KW - Mycotoxins KW - ergovaline KW - 2873-38-3 KW - lolitrem B KW - 81771-19-9 KW - Index Medicus KW - Animals KW - Cattle KW - Sheep Diseases -- pathology KW - Sheep KW - Poaceae KW - Retrospective Studies KW - Sheep Diseases -- etiology KW - Cold Temperature KW - Acremonium -- metabolism KW - Male KW - Female KW - Chromatography, High Pressure Liquid KW - Plants, Toxic -- chemistry KW - Foot Diseases -- veterinary KW - Mycotoxicosis -- pathology KW - Plant Poisoning -- veterinary KW - Ergotamines -- poisoning KW - Foot Diseases -- chemically induced KW - Ergotamines -- analysis KW - Plant Poisoning -- etiology KW - Animal Feed -- poisoning KW - Animal Feed -- analysis KW - Tremor -- veterinary KW - Mycotoxicosis -- veterinary KW - Mycotoxins -- poisoning KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70884567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Correlation+of+endophyte+toxins+%28ergovaline+and+lolitrem+B%29+with+clinical+disease%3A+fescue+foot+and+perennial+ryegrass+staggers.&rft.au=Tor-Agbidye%2C+J%3BBlythe%2C+L+L%3BCraig%2C+A+M&rft.aulast=Tor-Agbidye&rft.aufirst=J&rft.date=2001-06-01&rft.volume=43&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of chlorpyrifos exposures and urinary 3,5,6-trichloro-2-pyridinol levels among termiticide applicators. AN - 70878768; 11378153 AB - The exposures and work activities of 41 applicators in North Carolina using chlorpyrifos-containing termiticides were characterized. Personal air and urine samples were collected on multiple days within one week. Detailed information about chemical use, tasks, personal protective equipment and hygiene was recorded. During the 202 applicator-days monitored, 415 treatment jobs were performed. Full-shift chlorpyrifos exposures ranged from <0.048 to 110 microg/m(3) (N=184), with a geometric mean (GM) of 10 microg/m(3). Urinary 3,5,6-trichloro-2-pyridinol (TCP) levels ranged from 9.42 to 1960 microg/g creatinine (N=271) and varied significantly by day of the week (GM range: 169-262 microg/g creatinine). Predictive models for chlorpyrifos air exposure and urinary TCP levels were developed using mixed-effects stepwise linear regression. Determinants of airborne chlorpyrifos exposure included minutes chlorpyrifos applied and enclosed crawl space treated (yes/no). Determinants of TCP levels (depending on the model) included day-of-the-week, the chlorpyrifos air concentration one and two days before urine collection, minutes of chlorpyrifos applied one and two days before urine collection, enclosed crawl space treated (yes/no), and commercial structure treated (time-weighted). Within- and between-worker variability was similar for airborne chlorpyrifos; however, for TCP, between-worker variability exceeded within-worker variability by six times. The elimination half-life of TCP (26.9 h) and possibly the short sampling interval (one week) may explain the low TCP within-worker variability. Applicators' weekly mean ln(TCP levels) and weekly mean ln(chlorpyrifos air concentrations) were highly and positively linearly correlated (r(2)=0.73, P<0.0001). In summary, mixed-effects models were successfully constructed to predict airborne chlorpyrifos exposure and urinary TCP levels. JF - The Annals of occupational hygiene AU - Hines, C J AU - Deddens, J A AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. chines@cdc.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 309 EP - 321 VL - 45 IS - 4 SN - 0003-4878, 0003-4878 KW - Biomarkers KW - 0 KW - Insecticides KW - Pyridones KW - 3,5,6-trichloro-2-pyridinol KW - 6515-38-4 KW - Chlorpyrifos KW - JCS58I644W KW - Index Medicus KW - Analysis of Variance KW - Risk Factors KW - Humans KW - North Carolina KW - Linear Models KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Pyridones -- urine KW - Insecticides -- pharmacokinetics KW - Insecticides -- urine KW - Occupational Exposure -- analysis KW - Chlorpyrifos -- urine KW - Chlorpyrifos -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70878768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Determinants+of+chlorpyrifos+exposures+and+urinary+3%2C5%2C6-trichloro-2-pyridinol+levels+among+termiticide+applicators.&rft.au=Hines%2C+C+J%3BDeddens%2C+J+A&rft.aulast=Hines&rft.aufirst=C&rft.date=2001-06-01&rft.volume=45&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. AN - 70874714; 11353138 AB - The molecular mechanisms of carcinogenesis by cadmium were studied using BALB/c-3T3 cell transformation and nude mouse tumorigenesis models. BALB/c-3T3 cells transformed with cadmium chloride were subcutaneously injected into nude mice to develop tumors and the cell lines derived from these tumors were used in the present study. The proto-oncogenes c-fos and c-jun were overexpressed in 100% (10 out of 10) of the cell lines, while a statistically significant overexpression of c-myc was observed in 40% (4 out of 10) of the cell lines. Analysis of tumor cells stained with fluorescent dyes specific for reactive oxygen species revealed that these cells possessed markedly higher levels of superoxide anion and hydrogen peroxide compared with the nontransformed cells. Similarly, the intracellular calcium level was higher in the tumor cells compared with the nontransformed cells. Overexpression of the proto-oncogenes in these cells was blocked by treating the cells with superoxide dismutase, catalase, and 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetra acetoxy methyl ester (BAPTA/AM), which are scavengers of superoxide anion, hydrogen peroxide, and calcium, respectively. This confirmed that the overexpression of the proto-oncogenes in the tumor cells required elevated intracellular levels of reactive oxygen species and calcium. In addition to the scavengers of reactive oxygen species and calcium, inhibitors specific for transcription (actinomycin D), protein kinase C (RO-31-8220), and MAP kinase (PD 98059) also blocked the cadmium-induced overexpression of the proto-oncogenes in the tumor cells. Exposure of the nontransformed BALB/c-3T3 cells to 20 microM cadmium chloride for 1 h caused elevated intracellular levels of superoxide anion, hydrogen peroxide, and calcium, with corresponding increases in the expression levels of c-fos, c-jun, and c-myc. As in the case of the tumor cells, treating the nontransformed cells with the various modulators prior to their exposure to cadmium chloride resulted in inhibition in the expression of the proto-oncogenes. Based on these data, we conclude that the cadmium-induced overexpression of cellular proto-oncogenes is mediated by the elevation of intracellular levels of superoxide anion, hydrogen peroxide, and calcium. Further, the cadmium-induced overexpression of the proto-oncogenes is dependent on transcriptional activation as well as on pathways involving protein kinase C and MAP kinase. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Joseph, P AU - Muchnok, T K AU - Klishis, M L AU - Roberts, J R AU - Antonini, J M AU - Whong, W Z AU - Ong , T AD - Toxicology and Molecular Biology Branch, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. pcj5@cdc.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 295 EP - 303 VL - 61 IS - 2 SN - 1096-6080, 1096-6080 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Flavonoids KW - Free Radical Scavengers KW - Indoles KW - Reactive Oxygen Species KW - Cadmium KW - 00BH33GNGH KW - 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester KW - 139890-68-9 KW - Dactinomycin KW - 1CC1JFE158 KW - Egtazic Acid KW - 526U7A2651 KW - RNA KW - 63231-63-0 KW - Mitogen-Activated Protein Kinase Kinases KW - EC 2.7.12.2 KW - Calcium KW - SY7Q814VUP KW - Ro 31-8220 KW - W9A0B5E78O KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - 3T3 Cells KW - Animals KW - Analysis of Variance KW - Egtazic Acid -- analogs & derivatives KW - Blotting, Northern KW - Dactinomycin -- antagonists & inhibitors KW - Calcium -- analysis KW - Flavonoids -- antagonists & inhibitors KW - RNA -- analysis KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Inbred BALB C KW - Mitogen-Activated Protein Kinase Kinases -- metabolism KW - Calcium -- metabolism KW - Egtazic Acid -- antagonists & inhibitors KW - Indoles -- antagonists & inhibitors KW - Tumor Cells, Cultured KW - RNA -- isolation & purification KW - Cadmium -- pharmacology KW - Cell Transformation, Neoplastic -- pathology KW - Cell Transformation, Neoplastic -- chemically induced KW - Genes, fos -- genetics KW - Genes, myc -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Genes, jun -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70874714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Cadmium-induced+cell+transformation+and+tumorigenesis+are+associated+with+transcriptional+activation+of+c-fos%2C+c-jun%2C+and+c-myc+proto-oncogenes%3A+role+of+cellular+calcium+and+reactive+oxygen+species.&rft.au=Joseph%2C+P%3BMuchnok%2C+T+K%3BKlishis%2C+M+L%3BRoberts%2C+J+R%3BAntonini%2C+J+M%3BWhong%2C+W+Z%3BOng+%2C+T&rft.aulast=Joseph&rft.aufirst=P&rft.date=2001-06-01&rft.volume=61&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multigenerational evaluation of sodium fluoride in rats. AN - 70840608; 11346491 AB - Since the mid 1940s, fluoride has been added to tap water in American communities in an effort to reduce the incidence of dental caries in the population. When the levels of fluoride in drinking water were tested and set, water was the only measurable source of fluoride for most communities. Now, adults and children ingest fluoride with foods and beverages prepared with fluoridated water, and they are exposed to fluoride-containing dental products. As a result, exposure to fluoride is greater than had been anticipated. In the early 1990s, the existing reproductive studies were reviewed in several reports and were considered to be inadequate to determine potential reproductive or developmental hazards. The effects of sodium fluoride ingestion at 0, 25, 100, 175 or 250 ppm in drinking water measured in rats throughout three generations are reported here. Feed and fluid consumption, body weights and clinical signs were recorded at regular intervals. Decreased fluid consumption observed at 175 and 250 ppm was attributed to decreased palatability and did not affect reproduction. No cumulative effects were observed in the three generations. Mating, fertility and survival indices were not affected. Organ-to-body-weight ratios and organ-to-brain weight ratios were not affected. Sodium fluoride up to 250 ppm did not affect reproduction in rats. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Collins, T F AU - Sprando, R L AU - Black, T N AU - Shackelford, M E AU - Bryant, M A AU - Olejnik, N AU - Ames, M J AU - Rorie, J I AU - Ruggles, D I AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. tfc@cfsan.fda.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 601 EP - 613 VL - 39 IS - 6 SN - 0278-6915, 0278-6915 KW - Sodium Fluoride KW - 8ZYQ1474W7 KW - Index Medicus KW - Eating -- drug effects KW - Weight Gain -- drug effects KW - Animals KW - Tooth -- drug effects KW - Pregnancy KW - Sexual Behavior, Animal -- drug effects KW - Rats KW - Lactation -- drug effects KW - No-Observed-Adverse-Effect Level KW - Drinking -- drug effects KW - Body Weight -- drug effects KW - Female KW - Male KW - Fertility -- drug effects KW - Organ Size -- drug effects KW - Reproduction -- drug effects KW - Sodium Fluoride -- administration & dosage KW - Sodium Fluoride -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70840608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Multigenerational+evaluation+of+sodium+fluoride+in+rats.&rft.au=Collins%2C+T+F%3BSprando%2C+R+L%3BBlack%2C+T+N%3BShackelford%2C+M+E%3BBryant%2C+M+A%3BOlejnik%2C+N%3BAmes%2C+M+J%3BRorie%2C+J+I%3BRuggles%2C+D+I&rft.aulast=Collins&rft.aufirst=T&rft.date=2001-06-01&rft.volume=39&rft.issue=6&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - The Key Ingredient of the National Prevention Agenda: Workforce Development. A Companion Document to Healthy People 2010. AN - 62262497; ED461717 AB - This guide was developed to assist states in addressing the national workforce development objectives for the health professions and for employees of public health agencies in order to achieve the National Healthy People 2010 workforce objectives. The guide is organized in four sections. The opening section is a "how to" resource for planners. It provides seven strategy options for including workforce objectives in state Healthy People or other health plans. Two following sections focus on these three national Healthy People 2010 workforce objectives: (1) increasing the members of under-represented racial and ethnic groups in the health professions; (2) increasing the proportion of government agencies that incorporate specific competencies in the essential public health services into personnel systems; and (3) increasing the proportion of government health agencies that provide continuing education to develop competency in essential public health services for their employees. Each section on specific workforce objectives includes an issue summary, a strategy summary, examples of strategy implementation, and resources. The final section of the document provides a listing of all the Healthy People 2010 workforce-related objectives. Appendixes include a bibliography of articles and resources for increasing minority representation in the health professions and for continuing education in public health. A list of core public health competencies is included. (KC) Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 54 PB - Health Resources and Services Administration, 5600 Fishers Lane, Rockville, MD 20857. Tel: 888-275-4722 (Toll Free); Web site: http://www.ask.hrsa.gov/catalog.cfm. For full text: http://bhpr.hrsa.gov/healthworkforce. KW - Healthy People 2010 KW - Public Health Service KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Policymakers KW - Practitioners KW - Professional Occupations KW - Government Role KW - Public Policy KW - Adults KW - Health Education KW - Professional Continuing Education KW - Health Promotion KW - Public Health KW - Minority Groups KW - Health Behavior KW - Labor Force Development KW - State Programs KW - Health Programs KW - Competence KW - Recruitment KW - Health Occupations KW - Public Service Occupations KW - Prevention KW - Public Agencies KW - Policy Formation KW - Health Personnel KW - Preventive Medicine KW - Guides KW - Futures (of Society) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62262497?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For "Healthy People 2010," see ED 443 794-795. Kar N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - The study of central Taiwan particles concentration variations during earthquake period AN - 52179842; 2001-076729 JF - Environment International AU - Fang, Guor-Cheng AU - Chang, Cheng-Nan AU - Wu, Yuh-Shen AU - Fu, Peter Pi-Cheng AU - Yuen, Win-Hsiao AU - Cheng, Chii-Dong AU - Chen, Shun-Chin Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 561 EP - 566 PB - Pergamon, New York-Oxford VL - 26 IS - 7-8 SN - 0160-4120, 0160-4120 KW - central Taiwan KW - concentration KW - Taiwan KW - Far East KW - Taichung Taiwan KW - statistical analysis KW - pollution KW - aftershocks KW - sampling KW - Chi-Chi earthquake 1999 KW - air KW - Asia KW - earthquakes KW - particles KW - 19:Seismology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52179842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+International&rft.atitle=The+study+of+central+Taiwan+particles+concentration+variations+during+earthquake+period&rft.au=Fang%2C+Guor-Cheng%3BChang%2C+Cheng-Nan%3BWu%2C+Yuh-Shen%3BFu%2C+Peter+Pi-Cheng%3BYuen%2C+Win-Hsiao%3BCheng%2C+Chii-Dong%3BChen%2C+Shun-Chin&rft.aulast=Fang&rft.aufirst=Guor-Cheng&rft.date=2001-06-01&rft.volume=26&rft.issue=7-8&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Environment+International&rft.issn=01604120&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01604120 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 17 N1 - Document feature - illus. incl. 4 tables, sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aftershocks; air; Asia; central Taiwan; Chi-Chi earthquake 1999; concentration; earthquakes; Far East; particles; pollution; sampling; statistical analysis; Taichung Taiwan; Taiwan ER - TY - JOUR T1 - Bioaerosol lung damage in a worker with repeated exposure to fungi in a water-damaged building. AN - 21245297; 7697065 AB - There has been increased concern over health effects related to potential exposure of building occupants to bioaerosols. We report the case of a worker with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. We performed environmental tests to evaluate potential exposure to fungi, and we used mycotoxin-specific IgG antibody in serologic studies in the attempt to evaluate exposure to mycotoxins. Extensive fungal contamination was documented in many areas of the building. Penicillium, Aspergillus, and Stachybotrys species were the most predominant fungi found in air sampling. Our serologic test was not useful in differentiating workers who were probably occupationally exposed to mycotoxins from those who were not; however, it did yield evidence that individuals may make specific IgG antibodies to macrocyclic tricothecene mycotoxins. Further research is needed concerning health effects related to bioaerosol exposures, particularly regarding markers of exposure to specific fungi that may produce mycotoxins. In the absence of clinical tools specific for evaluation of mycotoxin-related illness, a systematic clinical approach for evaluating persons with suspected building-related respiratory illness is warranted. JF - Environmental Health Perspectives AU - Trout, D AU - Bernstein, J AU - Martinez, K AU - Biagini, R AU - Wallingford, K AD - Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA, DTrout@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 641 EP - 644 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 VL - 109 IS - 6 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts KW - Penicillium KW - Fungi KW - Airborne microorganisms KW - Aspergillus KW - Mycotoxins KW - Lung KW - Stachybotrys KW - Air sampling KW - Occupational exposure KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21245297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Bioaerosol+lung+damage+in+a+worker+with+repeated+exposure+to+fungi+in+a+water-damaged+building.&rft.au=Trout%2C+D%3BBernstein%2C+J%3BMartinez%2C+K%3BBiagini%2C+R%3BWallingford%2C+K&rft.aulast=Trout&rft.aufirst=D&rft.date=2001-06-01&rft.volume=109&rft.issue=6&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Aspergillus; Penicillium; Stachybotrys; Mycotoxins; Fungi; Airborne microorganisms; Occupational exposure; Lung; Air sampling ER - TY - JOUR T1 - Role of Veterinary Medicine in Public Health: Antibiotic Use in Food Animals and Humans and the Effect on Evolution of Antibacterial Resistance AN - 21192268; 11643775 AB - Veterinary public health is another frontier in the fight against human disease. The veterinary public health scope includes the control and eradication of zoonoses, diseases that are naturally transmitted between vertebrate animals and man. These diseases pose a continuous hazard to the health and welfare of the public. More than 100 diseases are categorized as zoonoses, including salmonellosis. It is important to understand how antibiotics are used in humans and in food animals and how these uses affect the evolution of antibacterial resistance. Appropriate use of antibiotics for food animals will preserve the long-term efficacy of existing antibiotics, support animal health and welfare, and limit the risk of transfer of antibiotic resistance to humans. An understanding of the epidemiology of antimicrobial resistance allows development of preventive strategies to limit existing resistance and to avoid emergence of new strains of resistant bacteria. Risk assessments are being used by the Center for Veterinary Medicine at the U.S. Food and Drug Administration as regulatory tools to assess potential risk to humans resulting from antibiotic use in food-producing animals and to then develop microbial safety policies to protect the public health. The veterinary public health scope, in addition to the control and eradication of zoonoses, also includes the development and supervision of food hygiene practices, laboratory and research activities, and education of the public. Thus, it may be seen that there are many ways in which veterinary medicine plays a very important role in public health. JF - Journal of Clinical Pharmacology AU - Lathers, Claire M AD - U.S. Food and Drug Administration (FDA), Center for Veterinary Medicine, Rockville, Maryland. Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Room 390, HFV-100, 7500 Standish Place, Rockville, MD Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 595 EP - 599 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 41 IS - 6 SN - 0091-2700, 0091-2700 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology KW - Risk assessment KW - Animals KW - antibiotic resistance KW - Drug resistance KW - Antibiotics KW - Public health KW - Veterinary medicine KW - zoonoses KW - Salmonidae KW - Drugs KW - Antibiotic resistance KW - USA KW - Education KW - Zoonoses KW - Epidemiology KW - Salmonellosis KW - Hygiene KW - antimicrobial agents KW - Evolution KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21192268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Role+of+Veterinary+Medicine+in+Public+Health%3A+Antibiotic+Use+in+Food+Animals+and+Humans+and+the+Effect+on+Evolution+of+Antibacterial+Resistance&rft.au=Lathers%2C+Claire+M&rft.aulast=Lathers&rft.aufirst=Claire&rft.date=2001-06-01&rft.volume=41&rft.issue=6&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F009127000104100601 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Veterinary medicine; Zoonoses; Epidemiology; Salmonellosis; Drug resistance; Antibiotics; Hygiene; Antibiotic resistance; Evolution; Public health; Animals; Education; antibiotic resistance; zoonoses; Drugs; antimicrobial agents; Salmonidae; USA DO - http://dx.doi.org/10.1177/009127000104100601 ER - TY - JOUR T1 - Occupational exposures during the World Trade Center disaster response AN - 18673878; 5562020 AB - Upon the request of the New York City Department of Health, the Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health (NIOSH) monitored occupational exposures among emergency response workers during the rescue and recovery activities at the World Trade Center disaster site from September 18 through 4 October 2001. During this period, over 1200 bulk and air samples were collected to estimate or characterize workers' occupational exposures. Samples were collected and analyzed for asbestos, carbon monoxide (CO), chlorodifluoromethane (Freon registered 22), diesel exhaust, hydrogen sulfide, inorganic acids, mercury and other metals, polynuclear aromatic hydrocarbons, respirable particulate not otherwise regulated (PNOR), respirable crystalline silica, total PNOR, and volatile organic compounds. Exposures to most of these potential hazards did not exceed NIOSH Recommended Exposure Limits or Occupational Safety and Health Administration Permissible Exposure Limits. However, one torch cutter was overexposed to cadmium and another worker (and possibly three others) was overexposed to CO. The elevated cadmium and CO levels were the result of workers using oxy-acetylene cutting torches and gasoline-powered cutting saws. Recommendations were made to ensure adequate ventilation and worker understanding when using these tools and, where possible, to substitute rechargeable, battery-powered cutting saws for gasoline-powered ones. JF - Toxicology and Industrial Health AU - Wallingford, K M AU - Snyder, E M AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-11), Cincinnati, OH 45226, USA, kwallingford@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 247 EP - 253 VL - 17 IS - 5-10 SN - 0748-2337, 0748-2337 KW - September 11th KW - World Trade Center Disaster KW - man KW - polynuclear aromatic hydrocarbons KW - terrorism KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - X 24240:Miscellaneous KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18673878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Occupational+exposures+during+the+World+Trade+Center+disaster+response&rft.au=Wallingford%2C+K+M%3BSnyder%2C+E+M&rft.aulast=Wallingford&rft.aufirst=K&rft.date=2001-06-01&rft.volume=17&rft.issue=5-10&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1191%2F0748233701th112oa LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1191/0748233701th112oa ER - TY - JOUR T1 - Dietary exposures to persistent organic pollutants AN - 18673794; 5562013 AB - As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Applied Nutrition (CFSAN) is primarily interested in POPs as humans may be exposed to these compounds through food. Examples of POPs found in food include dioxins, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers, and some pesticide chemicals. This overview discusses various sources of data that CFSAN has used to estimate dietary exposure to POPs, and provides an example of a recent calculation of an estimate for dietary exposure for consumers in the USA to dioxins in the food supply. JF - Toxicology and Industrial Health AU - Jensen, E AU - Egan, S K AU - Canady, R A AU - Bolger, P M AD - US Food and Drug Administration, HFS-355, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA, mbolger@cfsan.fda.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 157 EP - 162 VL - 17 IS - 5-10 SN - 0748-2337, 0748-2337 KW - persistant organic pollutants KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - H 14000:Toxicology KW - X 24250:Reviews KW - H 4000:Food and Drugs KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18673794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Dietary+exposures+to+persistent+organic+pollutants&rft.au=Jensen%2C+E%3BEgan%2C+S+K%3BCanady%2C+R+A%3BBolger%2C+P+M&rft.aulast=Jensen&rft.aufirst=E&rft.date=2001-06-01&rft.volume=17&rft.issue=5-10&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1191%2F0748233701th104oa LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1191/0748233701th104oa ER - TY - JOUR T1 - Evaluation of immunotoxicity induced by single or concurrent exposure to N,N-diethyl-m-toluamide (DEET), pyridostigmine bromide (PYR), and JP-8 jet fuel AN - 18668909; 5562017 AB - Approximately 5000 to 80 000 of the US service personnel involved in the Persian Gulf War have complained of a variety of nonspecific symptoms since their return in 1991. These symptoms have been collectively labeled Gulf War Illness and include muscle fatigue, general malaise, myalgia, impaired cognition, ataxia, headaches, fever, joint pain, skin rash, gastrointestinal disturbances, sleep disturbances, and respiratory difficulties. Exposures of military and service personnel were diverse and included the prescribed anti-nerve gas agent pyridostigmine bromide (PYR), N,N-diethyl-m-toluamide (DEET) insect repellent, and environmental exposures to jet fuel. Thus, studies in our laboratory were undertaken to determine if concurrent exposure to these agents, singly or in combination, would contribute to significant alterations in immunological function and disease susceptibility. To assess immune status, eight-week old B6C3F1 female mice were exposed for 14 days to single compounds or tertiary mixtures of 15.5 mg/kg DEET, 2 mg/kg PYR, and 500 mg/kg JP-8 (termed low dose), or 31 mg/kg DEET, 5 mg/kg PYR, and 1000 mg/kg JP-8 (termed high dose). Immunosuppression was assessed 24 h after the last exposure. No remarkable alterations were evident in hematological parameters, spleen and thymus organ weight and total cellularity, natural killer (NK) cell activity, cytotoxic T-cell activity, or mitogen-induced lymphocyte proliferation after exposure to either single or tertiary mixtures at low or high doses. A few changes in CD4/CD8 flow cytometric lymphocyte subpopulations were detected after exposure to the tertiary mixture at the high dose. Delayed type hypersensitivity (DTH) was decreased by 88% after exposure to the high-dose mixture, and suppression of antibody-specific IgM immune responses (plaque-forming cell, PFC) occurred after exposure to all single and tertiary mixtures at both dose levels. In the PFC response, antagonism was apparent in the mixture, while coexposure to these agents resulted in a synergistic effect in the DTH response. Susceptibility to B16F10 tumor or Listeria monocytogenes challenge was not affected after single or tertiary exposures. These data suggest that combined exposure to DEET, PYR, and JP-8 does not profoundly alter many immunological endpoints, but does selectively target functional endpoints such as the PFC and DTH response. This should be considered when assessing human health risks in the military environment. JF - Toxicology and Industrial Health AU - Peden-Adams, M M AU - Eudaly, J AU - Eudaly, E AU - Dudley, A AU - Zeigler, J AU - Lee, A AU - Robbs, J AU - Gilkeson, G AU - Keil, DE AD - Agriculture and Immunotoxicology Group, NIOSH/CDC, 1095 Willowdale Road, M/S L1119, Morgantown, WV 26505-2888, USA, dkeil@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 192 EP - 209 VL - 17 IS - 5-10 SN - 0748-2337, 0748-2337 KW - JP-8 jet fuel KW - N,N-Diethyl-m-toluamide KW - mice KW - Toxicology Abstracts KW - X 24132:Chronic exposure KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18668909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Evaluation+of+immunotoxicity+induced+by+single+or+concurrent+exposure+to+N%2CN-diethyl-m-toluamide+%28DEET%29%2C+pyridostigmine+bromide+%28PYR%29%2C+and+JP-8+jet+fuel&rft.au=Peden-Adams%2C+M+M%3BEudaly%2C+J%3BEudaly%2C+E%3BDudley%2C+A%3BZeigler%2C+J%3BLee%2C+A%3BRobbs%2C+J%3BGilkeson%2C+G%3BKeil%2C+DE&rft.aulast=Peden-Adams&rft.aufirst=M&rft.date=2001-06-01&rft.volume=17&rft.issue=5-10&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1191%2F0748233701th120oa LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1191/0748233701th120oa ER - TY - JOUR T1 - Biocides, drug resistance and microbial evolution AN - 18613568; 5490134 AB - Antimicrobial biocides are widely used in critical human health situations in which rigorous infection control is needed. Increasingly, biocidal agents are being marketed for home use, although there is little evidence that they significantly improve home hygiene. Biocide resistance mechanisms share many themes with antibiotic resistance mechanisms. JF - Current Opinion in Microbiology AU - White, D G AU - McDermott, P F AD - Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA, dwhite@cvm.fda.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 313 EP - 317 VL - 4 IS - 3 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - A 01064:Microbial resistance KW - J 02783:Antibiotics: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18613568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Biocides%2C+drug+resistance+and+microbial+evolution&rft.au=White%2C+D+G%3BMcDermott%2C+P+F&rft.aulast=White&rft.aufirst=D&rft.date=2001-06-01&rft.volume=4&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - External radiation exposure in a cohort of U.S. radiologic technologists (1977-1998) AN - 18502893; 5475092 AB - As part of a National Cancer Institute cohort investigation of cancer risk among 110,000 radiologic technologists, the National Institute for Occupational Safety and Health is undertaking a detailed assessment to estimate individual occupational radiation exposures using dosimetry data from commercial and other dosimetry providers and work history data obtained from mailed questionnaires for the years 1926-1998. Computerized annual dosimetry badge readings (N=1.3 million records for 97,000 technologists), available for the period 1977-1998, were used to evaluate exposure trends during this time period. The arithmetic mean badge dose for the cohort was found to decrease in an approximately exponential manner from 2.9 mSv in 1977 to 0.3 mSv in 1998. Fewer than 1.6% of the measured annual doses were greater than 10 mSv. The geometric mean annual doses for this population were 0.5 and 0.04 mSv for 1977 and 1998, respectively. The percentage of workers with no detectable exposure increased from 20% in 1977 to almost 60% in 1998. Within each year, the geometric standard deviations were large (ranging from about 8 to 10). Badge dose was correlated with several occupational characteristics based on a single factor analysis of variance. The parameters most strongly correlated were: 1) frequency of fluoroscopy usage (monthly, weekly, daily, or never); 2) type of facility (hospital or physician office); 3) calendar year of exposure; 4) dosimeter placement relative to the apron; and 5) diagnostic radionuclide usage. A statistical model that included all of these factors was found to explain about 30% of the variance in the data. This model will be applied to estimate annual doses for cohort members who worked during this time period and for whom badge doses are not available. JF - Health Physics AU - Neton, J W AU - Wenzl, T B AU - Ju, J AU - Cardarelli, J J AU - Doody, M M AU - Freeman, D M AU - Mohan, A K AU - Alexander, B H AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R44, Cincinnati, OH 45226, USA Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 1 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA VL - 80 IS - 6 SN - 0017-9078, 0017-9078 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - R2 23080:Industrial and labor KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18502893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=External+radiation+exposure+in+a+cohort+of+U.S.+radiologic+technologists+%281977-1998%29&rft.au=Neton%2C+J+W%3BWenzl%2C+T+B%3BJu%2C+J%3BCardarelli%2C+J+J%3BDoody%2C+M+M%3BFreeman%2C+D+M%3BMohan%2C+A+K%3BAlexander%2C+B+H&rft.aulast=Neton&rft.aufirst=J&rft.date=2001-06-01&rft.volume=80&rft.issue=6&rft.spage=S117&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Changes in radiation safety standards for laser products - A status report AN - 18501812; 5475094 AB - Products that are or incorporate lasers may be subject to one or more laser radiation safety standards. Those laser products that are intended for distribution in the United States are subject to the standard administered by the Center for Devices and Radiological Health, U.S. Food and Drug Administration and found in Title 21 of the Code of Federal Regulations, Parts 1040.10 and 1040.11 (the CDRH standard). Laser products intended for distribution in most other countries are subject to that of the International Electrotechnical Commission (IEC), IEC 60825-1. This IEC standard is effectively mandatory in the European Community as EN 60825-1. The American National Standards Institute (ANSI) Z136.1 standard is primarily a user safety standard but does include slightly different requirements for laser products that are "home made" for use in the workplace. The U.S. Department of Defense commonly uses the ANSI standard for laser products for combat or combat training that are exempted from the CDRH standard. Amendment 2 to IEC 60825-1 was published in January 2001. The CDRH has announced its intention to harmonize many of its requirements with those of the amended IEC standard. The changes involve new hazard classifications for laser products and measurement criteria for determining classification. This paper will describe these changes and also those areas where differences between the CDRH and IEC standards. JF - Health Physics AU - Figueroa, C AU - Dennis, J AD - Food and Drug Administration, Center for Devices and Radiological Health, 2094 Gaither Road, Rockville, MD 20850, USA Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 1 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA VL - 80 IS - 6 SN - 0017-9078, 0017-9078 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - R2 23090:Policy and planning KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18501812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Changes+in+radiation+safety+standards+for+laser+products+-+A+status+report&rft.au=Figueroa%2C+C%3BDennis%2C+J&rft.aulast=Figueroa&rft.aufirst=C&rft.date=2001-06-01&rft.volume=80&rft.issue=6&rft.spage=S128&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Use of Spent Irrigation Water for Microbiological Analysis of Alfalfa Sprouts AN - 18410962; 5398882 AB - Numerous outbreaks of foodborne illness have been linked to the consumption of raw sprouts. Sprout producers have been advised by the Food and Drug Administration to include microbiological testing of spent irrigation water during production as part of an overall strategy to enhance the safety of sprouts. Alfalfa sprouts and irrigation water were analyzed to show the feasibility of using irrigation water for monitoring the microbiological safety of sprouts. Sprouts and water were produced and harvested from both commercial-scale (rotary drum) and consumer-scale (glass jars) equipment. Rapid increases of aerobic mesophiles occurred during the first 24 h of sprouting, with maximum levels achieved after 48 to 72 h. The counts in irrigation water were on average within approximately 1 log of their respective counts in the sprouts. Similar results were obtained for analysis of Escherichia coli O157:H7 in irrigation water and sprouts grown from artifically inoculated seeds. Testing of spent irrigation water indicated the contamination status of alfalfa sprouts grown from seeds associated with outbreaks of Salmonella infection. JF - Journal of Food Protection AU - Fu, T AU - Stewart, D AU - Schlesser, J AU - Tortorello, M AU - Reineke, K AU - Ulaszek, J AD - U.S. Food and Drug Administration Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501, USA Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 802 EP - 806 VL - 64 IS - 6 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01017:Human foods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18410962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Use+of+Spent+Irrigation+Water+for+Microbiological+Analysis+of+Alfalfa+Sprouts&rft.au=Fu%2C+T%3BStewart%2C+D%3BSchlesser%2C+J%3BTortorello%2C+M%3BReineke%2C+K%3BUlaszek%2C+J&rft.aulast=Fu&rft.aufirst=T&rft.date=2001-06-01&rft.volume=64&rft.issue=6&rft.spage=802&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Xenotransplantation: regulatory challenges AN - 18161178; 5144910 AB - During 1999-2000, the US government published three xenotransplantation policy/guidance documents, one by the Public Health Service and two by the Food and Drug Administration (FDA). The FDA also held two public meetings of the xenotransplantation subcommittee of the Biological Response Modifiers Advisory Committee to discuss particular issues in xenotransplantation. JF - Current Opinion in Biotechnology AU - Bloom, E T AD - Division of Cellular and Gene Therapies (HFM-518), Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA, bloom@cber.fda.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 312 EP - 316 VL - 12 IS - 3 SN - 0958-1669, 0958-1669 KW - biological response modifiers KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Transplantation KW - Reviews KW - Government policy KW - Xenografts KW - W 30965:Miscellaneous, Reviews KW - W3 33000:General topics and reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18161178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Xenotransplantation%3A+regulatory+challenges&rft.au=Bloom%2C+E+T&rft.aulast=Bloom&rft.aufirst=E&rft.date=2001-06-01&rft.volume=12&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Xenografts; Government policy; Reviews; Transplantation ER - TY - JOUR T1 - The regulation of biologic products derived from bioengineered plants AN - 18158411; 5144909 AB - Recently, there has been a large increase in the number and types of biological products - from therapeutic antibodies to vaccines for the prevention of infectious diseases - that are produced in bioengineered plant systems. We anticipate that this technology will be used increasingly on a commercial scale for the manufacture of human and animal products. These production systems have the capacity to produce very large quantities of products at lower costs and with reduced risks compared with mammalian systems. JF - Current Opinion in Biotechnology AU - Stein, KE AU - Webber, KO AD - Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, 29 Lincoln Drive, Bethesda, MD 20892-4555, USA, stein@cber.fda.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 308 EP - 311 VL - 12 IS - 3 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Mammalian cells KW - Infectious diseases KW - Reviews KW - Genetic engineering KW - Disease control KW - Transgenic plants KW - W 30965:Miscellaneous, Reviews KW - W3 33000:General topics and reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18158411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=The+regulation+of+biologic+products+derived+from+bioengineered+plants&rft.au=Stein%2C+KE%3BWebber%2C+KO&rft.aulast=Stein&rft.aufirst=KE&rft.date=2001-06-01&rft.volume=12&rft.issue=3&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Transgenic plants; Genetic engineering; Infectious diseases; Disease control; Reviews; Mammalian cells ER - TY - JOUR T1 - Public health assessment of hexachlorobenzene AN - 18118992; 5210562 AB - Recently, hexachlorobenzene (HCB) was proposed for inclusion in the system of toxicity equivalency factors (TEFs) currently used for dioxin-like compounds. In this paper, we explore the practical implications of the proposition to the Agency for Toxic Substances and Disease Registry (ATSDR) programs by comparing respective health guidance values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and HCB (expressed as total toxicity equivalents [TEQs]), reviewing possible interactions between HCB and dioxin-like chemicals, and by providing information on actual co-existence of HCB and dioxin-like chemicals at hazardous waste sites. We found a good correlation between the TEF-adjusted oral exposure guidance values for HCB and guidance values for TCDD. The combination of HCB and other dioxin-like compounds was not found in soil, air, or water media at hazardous waste sites. Based on this fact, it is not necessary to include HCB in the total TEQ count at hazardous waste sites at this time. JF - Chemosphere AU - Pohl, H R AU - McClure, PR AU - Fay, M AU - Holler, J AU - De Rosa, CT AD - Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, mailstop E-29, 1600 Clifton Road, Atlanta, GA 30333, USA, hrp1@cdc.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 903 EP - 908 VL - 43 IS - 4-7 SN - 0045-6535, 0045-6535 KW - toxicity equivalency factors KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Risk assessment KW - Public health KW - Waste disposal sites KW - Reviews KW - Hexachlorobenzene KW - H 14000:Toxicology KW - X 24250:Reviews KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18118992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Public+health+assessment+of+hexachlorobenzene&rft.au=Pohl%2C+H+R%3BMcClure%2C+PR%3BFay%2C+M%3BHoller%2C+J%3BDe+Rosa%2C+CT&rft.aulast=Pohl&rft.aufirst=H&rft.date=2001-06-01&rft.volume=43&rft.issue=4-7&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hexachlorobenzene; Waste disposal sites; Reviews; Public health; Risk assessment ER - TY - JOUR T1 - Quadrupole ion storage tandem mass spectrometry and high-resolution mass spectrometry: complementary application in the measurement of 2,3,7,8-chlorine substituted dibenzo-p-dioxins and dibenzofurans in US foods AN - 18118897; 5210515 AB - The US Food and Drug Administration has simultaneously utilized both high-resolution mass spectrometry (HRMS) and quadrupole ion storage tandem mass spectrometry (QISTMS) in the measurement of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) in 147 food samples collected in 1998 and 1999 in the US. In 1998, 20 egg samples, six scallop, 10 blue crab, eight American lobster, 10 pollack, 15 striped bass, five rockfish, 10 crawfish, seven aqua-cultured and 13 wild-caught salmon, along with 19 cream and 18 mozzarella cheese samples were measured for PCDD/Fs. QISTMS provided limits of detection (LODs) close to those produced using HRMS for many congeners in 56 samples analyzed by both techniques in 1998 and three salmon and three striped bass collected in 1999. The I-TEQs of the mean levels for measured congeners in 40 samples of fish and shellfish and 16 cheese and eggs from 1998 analyzed by HRMS and QISTMS were 0.99 and 1.1 ng/kg wet weight, respectively. The I-TEQ for mean congener levels in the 40 fish and shellfish measured by HRMS was 1.4 ng/kg wet weight. A higher sample throughput with greater data quality at a lower cost is achievable by using both QISTMS and HRMS. JF - Chemosphere AU - Hayward, D G AU - Holcomb, J AU - Glidden, R AU - Wilson, P AU - Harris, M AU - Spencer, V AD - US Food and Drug Administration, Washington, DC 20204, USA Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 407 EP - 415 VL - 43 IS - 4-7 SN - 0045-6535, 0045-6535 KW - Toxicology Abstracts KW - Polychlorinated dibenzo(p)dioxins KW - Polychlorinated dibenzofurans KW - Food contamination KW - Mass spectroscopy KW - X 24120:Food, additives & contaminants KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18118897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Quadrupole+ion+storage+tandem+mass+spectrometry+and+high-resolution+mass+spectrometry%3A+complementary+application+in+the+measurement+of+2%2C3%2C7%2C8-chlorine+substituted+dibenzo-p-dioxins+and+dibenzofurans+in+US+foods&rft.au=Hayward%2C+D+G%3BHolcomb%2C+J%3BGlidden%2C+R%3BWilson%2C+P%3BHarris%2C+M%3BSpencer%2C+V&rft.aulast=Hayward&rft.aufirst=D&rft.date=2001-06-01&rft.volume=43&rft.issue=4-7&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mass spectroscopy; Polychlorinated dibenzo(p)dioxins; Polychlorinated dibenzofurans; Food contamination ER - TY - JOUR T1 - Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro AN - 17932353; 5160100 AB - Recent work from humans and chick embryos has suggested that homocysteine may play a role in producing neural tube defects (NTDs). In an effort to determine if homocysteine is able to produce NTDs in mammalian embryos, mouse embryos were explanted on GD 8 and cultured for 44 h. When either homocysteine or homocysteine thiolactone was added to the culture medium, treated embryos developed as well as controls and had closed neural tubes. Homocysteine thiolactone was also microinjected into the amniotic sac of mouse embryos. Again, development proceeded normally with no significant increase in the number of embryos with open neural tubes at the end of the culture period. HPLC analysis of embryonic thiols 24 h after microinjection revealed a significant increase in embryonic cystathionine levels. These data suggest that homocysteine does not produce NTDs in mouse embryos cultured in vitro and that early organogenesis-stage embryos are able to metabolize homocysteine. JF - Reproductive Toxicology AU - Hansen, D K AU - Grafton, T F AU - Melnyk, S AU - James, S J AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA, dhansen@nctr.fda.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 239 EP - 244 VL - 15 IS - 3 SN - 0890-6238, 0890-6238 KW - mice KW - homocysteine KW - Toxicology Abstracts KW - Organogenesis KW - Embryos KW - Neural tube defects KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17932353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Lack+of+embryotoxicity+of+homocysteine+thiolactone+in+mouse+embryos+in+vitro&rft.au=Hansen%2C+D+K%3BGrafton%2C+T+F%3BMelnyk%2C+S%3BJames%2C+S+J&rft.aulast=Hansen&rft.aufirst=D&rft.date=2001-06-01&rft.volume=15&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Embryos; Neural tube defects; Organogenesis ER - TY - JOUR T1 - Human Peripheral Blood T Cells, Monocytes, and Macrophages Secrete Macrophage Inflammatory Proteins 1 alpha and 1 beta following Stimulation with Heat-Inactivated Brucella abortus AN - 17869197; 5108828 AB - Heat-killed Brucella abortus (HBa) has been proposed as a carrier for therapeutic vaccines for individuals with immunodeficiency, due to its abilities to induce interleukin-2 (IL-2) and gamma interferon (IFN- gamma ) in both CD4 super(+) and CD8 super(+) T cells and to upregulate antigen-presenting cell functions (including IL-12 production). In the current study, we investigated the ability of HBa or lipopolysaccharide isolated from HBa (LPS-Ba) to elicit beta -chemokines, known to bind to the human immunodeficiency virus type 1 (HIV-1) coreceptor CCR5 and to block viral cell entry. It was found that human peripheral blood mononuclear cells secreted beta -chemokines following stimulation with HBa, and this effect could not be blocked by anti-IFN- gamma neutralizing antibodies. Among purified T cells, macrophage inflammatory protein 1 alpha and 1 beta (MIP-1 alpha and MIP-1 beta , respectively) secretion was observed primarily in human CD8 super(+) T cells. The kinetics of beta -chemokine induction in T cells were slow (3 to 4 days). The majority of beta -chemokine-producing CD8 super(+) T cells also produced IFN- gamma following HBa stimulation, as determined by triple-color intracellular staining. A significant number of CD8 super(+) T cells contained stored MIP-1 beta that was released after HBa stimulation. Both HBa and LPS-Ba stimulated high levels of MIP-1 alpha and MIP-1 beta production in elutriated monocytes and even higher levels in macrophages. In these cells, beta -chemokine mRNA was upregulated within 30 min and proteins were secreted within 4 h of stimulation. The monocyte- and macrophage-derived beta -chemokines were sufficient to block CCR5-dependent HIV-1 envelope-mediated cell fusion. These data suggest that, in addition to the ability of HBa to elicit antigen-specific humoral and cellular immune responses, HBa-conjugated HIV-1 proteins or peptides would also generate innate chemokines with antiviral activity that could limit local viral spread during vaccination in vivo. JF - Infection and Immunity AU - Zaitseva, M AU - King, L R AU - Manischewitz, J AU - Dougan, M AU - Stevan, L AU - Golding, H AU - Golding, B AD - Division of Hematology, Center for Biologics Evaluation and Research, FDA, HFM-345, Bldg. 29, Room 232, 8800 Rockville Pike, Bethesda, MD 20892, Golding@CBER.FDA.GOV Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 3817 EP - 3826 VL - 69 IS - 6 SN - 0019-9567, 0019-9567 KW - HIV-1 KW - man KW - Brucella abortus KW - human immunodeficiency virus 1 KW - macrophage inflammatory protein 1 alpha KW - macrophage inflammatory protein 1 beta KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - macrophage inflammatory protein 1a KW - macrophage inflammatory protein 1b KW - macrophage inflammatory protein 1^a KW - macrophage inflammatory protein 1^b KW - Macrophages KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Cytokines KW - Vaccines KW - Monocytes KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17869197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Human+Peripheral+Blood+T+Cells%2C+Monocytes%2C+and+Macrophages+Secrete+Macrophage+Inflammatory+Proteins+1+alpha+and+1+beta+following+Stimulation+with+Heat-Inactivated+Brucella+abortus&rft.au=Zaitseva%2C+M%3BKing%2C+L+R%3BManischewitz%2C+J%3BDougan%2C+M%3BStevan%2C+L%3BGolding%2C+H%3BGolding%2C+B&rft.aulast=Zaitseva&rft.aufirst=M&rft.date=2001-06-01&rft.volume=69&rft.issue=6&rft.spage=3817&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.69.6.3817-3826.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brucella abortus; Human immunodeficiency virus 1; Lymphocytes T; Macrophages; Monocytes; Cytokines; Vaccines DO - http://dx.doi.org/10.1128/IAI.69.6.3817-3826.2001 ER - TY - JOUR T1 - 2-Methoxyethanol metabolism, embryonic distribution, and macromolecular adduct formation in the rat: the effect of radiofrequency radiation-induced hyperthermia AN - 17927372; 5160080 AB - Exposure of pregnant rats to the solvent 2-methoxyethanol (2ME) and radiofrequency (RF) radiation results in greater than additive fetal malformations. The current study evaluated the metabolism of super(14)C-labeled 2ME and the distribution of methoxyacetic acid (MAA) in maternal and embryonic tissues of pregnant Sprague-Dawley rats either exposed to 10 MHz RF radiation or sham conditions. Additionally, adduct formation for both plasma and embryonic protein was tested as a possible biomarker for the observed 2ME/RF teratogenicity. Rats were administered [ethanol-1,2- super(14)C]-2ME (150 mg/kg, 161 mu Ci/rat average) by gavage on gestation day 13 immediately before RF radiation sufficient to elevate body temperature to 42 degree C for 30 min. Concurrent sham- and RF-exposed rats were sacrificed at 3, 6, 24 or 48 h for harvest of maternal blood, urine, embryos and extra-embryonic fluid. Tissues were either digested for determination of radioactivity or deproteinized with TCA and analyzed by HPLC for quantification of 2ME metabolites. Results show the presence of 2ME and seven metabolites, with the major metabolite, MAA, peaking at 6 h in the tissues tested. MAA, the proximal teratogen, was detectable in maternal serum, urine, embryo and extraembryonic fluid 48 h after dosing. Clearance of total body super(14)C was significantly reduced for the RF-exposed animals (P < 0.05) for the 24-48 h period, but MAA values for serum, embryos and extraembryonic fluid were similar for both sham- and RF-exposed rats. Additionally, no difference was noted for 2ME metabolite profiles in urine or tissue for sham- or RF-exposed rats, thus eliminating an effect of RF radiation on MAA production as a possible explanation for the reported RF-2ME synergism. Subsequently, serum and embryo protein-bound adducts were evaluated by analysis of covalently bound radioactivity. Serum protein binding was significantly higher for sham than RF rats at 3- and 6-h - highest for sham rats at 6 h (519 plus or minus 95 mu g as parent 2ME/g of protein) whereas RF serum values were highest at 24 h (266 plus or minus 79 mu g/g protein). Embryonic protein binding was significantly higher for sham rats at 6 h, but binding was highest for both groups at 24 h (sham = 229 plus or minus 71 mu g/g, RF = 185 plus or minus 48 mu g/g). Formation of protein adducts after 2ME is thought to be related to levels of methoxyacetaldehyde, a reactive intermediate in the formation of MAA. These results suggest that no direct relationship exists for covalent binding in the embryo which would explain RF-2ME synergistic malformations. In comparison with urinary metabolites, the relatively slow elimination of adducted serum 2ME indicates that analysis of protein-bound concentrations could be a potential tool for long-term biomonitoring of worker exposure. JF - Toxicology Letters AU - Cheever, K L AU - Swearengin, T F AU - Edwards, R M AU - Nelson, B K AU - Werren, D W AU - Conover, D L AU - DeBord, D G AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, klcl@cdc.gov Y1 - 2001/05/31/ PY - 2001 DA - 2001 May 31 SP - 53 EP - 67 VL - 122 IS - 1 SN - 0378-4274, 0378-4274 KW - ratas KW - 2-methoxyethanol KW - Toxicology Abstracts KW - Malformations KW - Hyperthermia KW - Radiation KW - Teratogenicity KW - Embryos KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17927372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=2-Methoxyethanol+metabolism%2C+embryonic+distribution%2C+and+macromolecular+adduct+formation+in+the+rat%3A+the+effect+of+radiofrequency+radiation-induced+hyperthermia&rft.au=Cheever%2C+K+L%3BSwearengin%2C+T+F%3BEdwards%2C+R+M%3BNelson%2C+B+K%3BWerren%2C+D+W%3BConover%2C+D+L%3BDeBord%2C+D+G&rft.aulast=Cheever&rft.aufirst=K&rft.date=2001-05-31&rft.volume=122&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Radiation; Hyperthermia; Embryos; Malformations; Teratogenicity ER - TY - JOUR T1 - Inter-species differences in drug properties. AN - 70815229; 11336972 AB - There has been a clear trend towards decreased reliance upon animal studies and increased emphasis upon experiments with human-derived tissues. Nonetheless, we continue to need investigations of interspecies differences for two principal reasons: (1) to prospectively design experiments so that the animal species most similar to humans can be chosen, on a case-by-case basis, for each drug; (2) to properly evaluate and interpret data obtained from the experiments ("risk assessment"). Four core examples derived from the work in our FDA laboratory are used to illustrate these points. For paclitaxel, different metabolites were formed in humans and rats, which makes metabolic drug-drug interaction studies in rats irrelevant. For zidovudine (AZT), rapid glucuronidation in humans produced a much shorter half-life than expected from studies in animals, which have negligible glucuronidation. The toxicology and efficacy of both parent drug and metabolite need to be assessed in cases such as iododeoxydoxorubicin, in which the parent molecule is the dominant circulating species in mice, but patients have more than 10-fold greater exposure to the metabolite compared with the parent. While rats have highly-active arylamine N-acetyltransferases, dogs totally lack this enzyme family, and humans have intermediate amounts. For some situations, we've suggested that it can be desirable to inhibit NAT to make the human exposure more similar to dogs. In conclusion, although the ratio of animal:human data is decreasing, our ability to use animal data effectively for drug development has actually increased. Continued focus should be placed upon the application of comparative interspecies data for prospective design of animal experiments and retrospective interpretation of animal findings in terms of the potential for human risk and benefit. JF - Chemico-biological interactions AU - Collins, J M AD - Laboratory of Clinical Pharmacology, Food and Drug Administration, 4 Research Court, Room 314, Rockville, MD 20850, USA. collinsj@cder.fda.gov Y1 - 2001/05/16/ PY - 2001 DA - 2001 May 16 SP - 237 EP - 242 VL - 134 IS - 3 SN - 0009-2797, 0009-2797 KW - Anti-HIV Agents KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Pharmaceutical Preparations KW - Zidovudine KW - 4B9XT59T7S KW - 4'-deoxy-4'-iododoxorubicin KW - 65JH75I9JX KW - Doxorubicin KW - 80168379AG KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - United States KW - Animals KW - Paclitaxel -- metabolism KW - United States Food and Drug Administration KW - Zidovudine -- metabolism KW - Anti-HIV Agents -- metabolism KW - Humans KW - Dogs KW - Research KW - Arylamine N-Acetyltransferase -- metabolism KW - Antineoplastic Agents, Phytogenic -- metabolism KW - Pharmaceutical Preparations -- metabolism KW - Doxorubicin -- analogs & derivatives KW - Doxorubicin -- metabolism KW - Species Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70815229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Inter-species+differences+in+drug+properties.&rft.au=Collins%2C+J+M&rft.aulast=Collins&rft.aufirst=J&rft.date=2001-05-16&rft.volume=134&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperthyroidism increases the risk of ozone-induced lung toxicity in rats. AN - 70850672; 11350211 AB - The risk of lung injury from ozone exposure has been well documented. It is also known that various factors may significantly influence the susceptibility of animals to the toxic effects of ozone. In the present study, we investigated the possibility that hyperthyroidism might be associated with increases in ozone-induced pulmonary toxicity. To create a hyperthyroid condition, mature male Sprague--Dawley rats were given injections of thyroxine (dose range: 0.1 to 1 mg/kg body wt daily for 7 days). Control rats received vehicle injections. The animals were then exposed to air or ozone (dose range: 0.5 to 3 ppm for 3 h). At 18 h postexposure, bronchoalveolar lavage fluid and cells were harvested. In hyperthyroid animals, ozone exposure was associated with three- to sixfold increases in bronchoalveolar lavage fluid lactate dehydrogenase activities and albumin levels as well as the number of polymorphonuclear leukocytes harvested by bronchoalveolar lavage above levels observed in ozone-exposed control rats. Additional results from the present study suggest that these thyroid hormone-linked effects cannot be fully explained by differences in whole-body metabolic rate or changes in the inhaled dose of ozone. These findings indicate that the risk of ozone-induced lung toxicity is substantially increased in a hyperthyroid state and suggest that the susceptibility of the lung to damage from ozone exposure may be significantly influenced by individual thyroid hormone status. JF - Toxicology and applied pharmacology AU - Huffman, L J AU - Judy, D J AU - Brumbaugh, K AU - Frazer, D G AU - Reynolds, J S AU - McKinney, W G AU - Goldsmith, W T AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2001/05/15/ PY - 2001 DA - 2001 May 15 SP - 18 EP - 26 VL - 173 IS - 1 SN - 0041-008X, 0041-008X KW - Albumins KW - 0 KW - Ozone KW - 66H7ZZK23N KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Animals KW - Basal Metabolism KW - L-Lactate Dehydrogenase -- analysis KW - Respiration -- drug effects KW - Thyroxine -- blood KW - Leukocyte Count KW - Tidal Volume KW - Rats KW - Edema -- chemically induced KW - Albumins -- analysis KW - Rats, Sprague-Dawley KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Neutrophils KW - Thyroxine -- administration & dosage KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Lung Diseases -- chemically induced KW - Ozone -- administration & dosage KW - Hyperthyroidism -- complications KW - Ozone -- toxicity KW - Hyperthyroidism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70850672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Hyperthyroidism+increases+the+risk+of+ozone-induced+lung+toxicity+in+rats.&rft.au=Huffman%2C+L+J%3BJudy%2C+D+J%3BBrumbaugh%2C+K%3BFrazer%2C+D+G%3BReynolds%2C+J+S%3BMcKinney%2C+W+G%3BGoldsmith%2C+W+T&rft.aulast=Huffman&rft.aufirst=L&rft.date=2001-05-15&rft.volume=173&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antimicrobial susceptibility data and new animal drug approval in the United States: a historical overview AN - 18071980; 4880990 AB - The requirements and procedures necessary to gain approval for a new animal drug in the United States are briefly reviewed with respect to the requirement and applicability of antimicrobial susceptibility testing data, in particular, as these relate to what is referred to as Professional Flexible Labeled (PFL) animal drugs. The history and process by which the National Committee for Clinical Laboratory Standards (NCCLS) has established internationally recognized and utilized antimicrobial susceptibility testing procedures is reviewed in the context of standardization of procedures used in the clinical veterinary setting. Both the NCCLS and the PFL topics are discussed relative to their applicability to antimicrobial resistance in aquatic species' isolates and their nexus to efforts to begin the process of developing and using standard procedures for aquatic isolates. JF - Aquaculture AU - Bell, T A AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Place, 20855 Rockville, MD USA Y1 - 2001/05/15/ PY - 2001 DA - 2001 May 15 SP - 245 EP - 251 PB - Elsevier Science VL - 196 IS - 3-4 SN - 0044-8486, 0044-8486 KW - historical account KW - Oceanic Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Historical account KW - Drug resistance KW - Disease control KW - Therapy KW - Brackish KW - Antibiotics KW - Pathogens KW - Freshwater KW - Microbiological culture KW - USA KW - Analytical techniques KW - Standards KW - Aquaculture techniques KW - A 01069:Antimicrobial & microbiocidal KW - Q1 08587:Diseases of Cultured Organisms KW - O 5060:Aquaculture KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18071980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquaculture&rft.atitle=Antimicrobial+susceptibility+data+and+new+animal+drug+approval+in+the+United+States%3A+a+historical+overview&rft.au=Bell%2C+T+A&rft.aulast=Bell&rft.aufirst=T&rft.date=2001-05-15&rft.volume=196&rft.issue=3-4&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Aquaculture&rft.issn=00448486&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Drug resistance; Analytical techniques; Therapy; Disease control; Antibiotics; Standards; Pathogens; Aquaculture techniques; Microbiological culture; Historical account; USA; Freshwater; Brackish; Marine ER - TY - JOUR T1 - Oxidative damage and stress response from ochratoxin A exposure in rats AN - 17905026; 5140425 AB - Ochratoxin A (OTA) is a mycotoxin found in some cereal and grain products. It is a potent renal carcinogen in male rats, although its mode of carcinogenic action is not known. Oxidative stress may play a role in OTA-induced toxicity and carcinogenicity. In this study, we measured several chemical and biological markers that are associated with oxidative stress response to determine if this process is involved in OTA-mediated toxicity in rats. Treatment of male rats with OTA (up to 2 mg/kg per os, 24 h exposure) did not increase the formation of biomarkers of oxidative damage such as the lipid peroxidation marker malondialdehyde in rat plasma, kidney, and liver, or the DNA damage marker 8-oxo-7,8-dihydro-2'deoxyguanosine in kidney DNA. However, OTA treatment (1 mg/kg) did result in a 22% decrease in alpha -tocopherol plasma levels and a 5-fold increase in the expression of the oxidative stress responsive protein haem oxygenase-1, specifically in the kidney. The selective alteration of these latter two markers indicates that OTA does evoke oxidative stress, which may contribute at least in part to OTA renal toxicity and carcinogenicity in rats during long-term exposure. JF - Free Radical Biology & Medicine AU - Gautier, J-C AU - Holzhaeuser, D AU - Markovic, J AU - Gremaud, E AU - Schilter, B AU - Turesky, R J AD - National Center for Toxicological Research, Division of Chemistry, 3900 NCTR Drive, Jefferson, AR 72079, USA, Rturesky@nctr.fda.gov Y1 - 2001/05/15/ PY - 2001 DA - 2001 May 15 SP - 1089 EP - 1098 VL - 30 IS - 10 SN - 0891-5849, 0891-5849 KW - rats KW - alpha -Tocopherol KW - heme oxygenase 1 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - a-Tocopherol KW - ^a-Tocopherol KW - Ochratoxin A KW - Carcinogens KW - Mycotoxins KW - Vitamin E KW - Oxidative stress KW - Kidney KW - K 03082:Mycotoxins KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17905026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+%26+Medicine&rft.atitle=Oxidative+damage+and+stress+response+from+ochratoxin+A+exposure+in+rats&rft.au=Gautier%2C+J-C%3BHolzhaeuser%2C+D%3BMarkovic%2C+J%3BGremaud%2C+E%3BSchilter%2C+B%3BTuresky%2C+R+J&rft.aulast=Gautier&rft.aufirst=J-C&rft.date=2001-05-15&rft.volume=30&rft.issue=10&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+%26+Medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vitamin E; Mycotoxins; Ochratoxin A; Carcinogens; Oxidative stress; Kidney ER - TY - JOUR T1 - Regulatory perspectives on in vitro (dissolution)/in vivo (bioavailability) correlations AN - 17908213; 5176186 AB - In vitro dissolution has been extensively used as a quality control tool for solid oral dosage forms. In several cases, however, it is not known whether one can predict the in vivo performance of these products from in vitro dissolution data. In an effort to minimize unnecessary human testing, investigations of in vitro/in vivo correlations (IVIVC) between in vitro dissolution and in vivo bioavailability are increasingly becoming an integral part of extended release (ER) drug product development. This increased activity in developing IVIVCs indicates the value of IVIVCs to the pharmaceutical industry. Because of the scientific interest and the associated utility of IVIVC as a valuable tool, the US Food and Drug Administration has published a Guidance in September 1997, entitled Extended Release Oral Dosage Forms: Development, Evaluation and Application of In Vitro/In Vivo Correlations. A predictive IVIVC enables in vitro dissolution to serve as a surrogate for in vivo bioequivalence testing. IVIVCs can be used in place of biostudies that may otherwise be required to demonstrate bioequivalence, when certain preapproval and postapproval changes are made in formulation, equipment, manufacturing process or in the manufacturing site. IVIVC development could lead to improved product quality (more meaningful dissolution specifications) and decreased regulatory burden (reduced biostudy requirements). This article will discuss in detail the FDA Guidance which deals with the development, evaluation methods and criteria, and applications of IVIVCs. From a regulatory point of view, the applications of IVIVC to grant biowaivers and to set dissolution specifications for ER oral dosage forms will be presented. Additionally, since the principles of IVIVC are considered to be similar for non-oral dosage forms, the guidance for oral extended release products may be applied for non-oral products as well. While the principles are likely to be the same, it is an interesting challenge to look at appropriate methods for dissolution testing and for development of in vitro/in vivo correlations for products such as injectable depot formulations. JF - Journal of Controlled Release AU - Uppoor, VRS AD - Office of Clinical Pharmacology and Biopharmaceutics, CDER, FDA, Rockville, MD 20857, USA Y1 - 2001/05/14/ PY - 2001 DA - 2001 May 14 SP - 127 EP - 132 VL - 72 IS - 1-3 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Bioavailability KW - Drug delivery KW - Dissolution KW - Pharmaceuticals KW - Controlled release KW - W3 33388:Drug delivery vehicles (liposomes, cochleates, microspheres) KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17908213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Regulatory+perspectives+on+in+vitro+%28dissolution%29%2Fin+vivo+%28bioavailability%29+correlations&rft.au=Uppoor%2C+VRS&rft.aulast=Uppoor&rft.aufirst=VRS&rft.date=2001-05-14&rft.volume=72&rft.issue=1-3&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Controlled release; Drug delivery; Bioavailability; Pharmaceuticals; Dissolution ER - TY - JOUR T1 - Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data. AN - 70829592; 11346132 AB - Physiologically based pharmacokinetic (PBPK) models are excellent tools to aid in the extrapolation of animal data to humans. When the fate of the chemical is the same among species being compared, animal data can appropriately be considered as a model for human exposure. For methylmercury exposure, sufficient data exist to allow comparison of numerous mammalian species to humans. PBPK model validation entails obtaining blood and tissue concentrations of the parent chemical and metabolite(s) at various times following a known exposure. From ethical and practical considerations, human tissue concentrations following a known exposure to an environmental toxicant are scarce. While animal-to-human extrapolation demands that sufficient human data exist to validate the model, the validation requirements are less stringent if multiple animal models are utilized within a single model template. A versatile PBPK model was used to analyze the distribution and elimination of methylmercury and its metabolite, inorganic mercury. Uniquely, the model is formed in a generic way from a single basic template during the initial program compilation. Basic parameters are defined for diffferent PBPK models for mammalian species that span a relatively large range of sizes. In this article, the analyses include 12 species (mouse, hamster, rat, guinea pig, cat, rabbit, monkey, sheep, pig, goat, cow, and human). Allometric (weight-based) correlations of tissue binding coefficients, metabolism rate constants, and elimination parameters for both methylmercury and inorganic mercury are presented for species for which sufficient data are available. The resulting human model, in accord with the animal models, predicts relatively high inorganic mercury levels in the kidneys long after the disappearance of methylmercury from the blood. JF - Journal of toxicology and environmental health. Part A AU - Young, J F AU - Wosilait, W D AU - Luecke, R H AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502, USA. jyoung@nctr.fda.gov Y1 - 2001/05/11/ PY - 2001 DA - 2001 May 11 SP - 19 EP - 52 VL - 63 IS - 1 SN - 1528-7394, 1528-7394 KW - Methylmercury Compounds KW - 0 KW - Index Medicus KW - Models, Animal KW - Animals KW - Reference Values KW - Reproducibility of Results KW - Humans KW - Tissue Distribution KW - Species Specificity KW - Models, Biological KW - Male KW - Female KW - Risk Assessment KW - Toxicology -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Mammals -- physiology KW - Methylmercury Compounds -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70829592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Analysis+of+methylmercury+disposition+in+humans+utilizing+a+PBPK+model+and+animal+pharmacokinetic+data.&rft.au=Young%2C+J+F%3BWosilait%2C+W+D%3BLuecke%2C+R+H&rft.aulast=Young&rft.aufirst=J&rft.date=2001-05-11&rft.volume=63&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ultrasonic extraction and field-portable anodic stripping voltammetric measurement of lead in dust wipe samples. AN - 77002544; 11267744 AB - Dust wipe samples were subjected to ultrasonic extraction (UE) in diluted nitric acid, and then analyzed for lead content using field-portable anodic stripping voltammetry (ASV). Recoveries of lead were determined from wipe materials which were spiked with certified reference materials (CRMs) containing known quantities of lead. Four different wipe materials and four different CRMs were tested, with and without filtration of aliquots of sample extract through 0.45 microm hydrophilic polytetrafluoroethylene filters. The CRMs consisted of paint, soil, particulate, and dust matrices. Wipe materials were chosen from those which have been found to meet the performance aspects of an ASTM standard specification. UE/ASV experiments were carried out in accordance with newly published ASTM procedures for on-site extraction and electroanalysis. Recoveries were found to vary for different wipe materials and CRMs. For several CRMs, quantitative (80--120%) recoveries for UE/ASV were observed for one wipe material whether filtration was used or not, while other wipe materials required filtration for quantitative recovery. In the case of one wipe material which contained detergents, quantitative recoveries could not be achieved whether filtration was used or not. The total analysis time for a sample set of 6--12 samples was 60--90 min, including extraction time and sample manipulation. The results of this work have provided information on the choice of wipe materials that can be used for quantitative lead measurements by UE/ASV in materials that are representative of sources of lead in surface dust. JF - Journal of hazardous materials AU - Ashley, K AU - Wise, T J AU - Mercado, W AU - Parry, D B AD - US Department of Health and Human Services Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. kashley@cdc.gov Y1 - 2001/05/07/ PY - 2001 DA - 2001 May 07 SP - 41 EP - 50 VL - 83 IS - 1-2 SN - 0304-3894, 0304-3894 KW - Dust KW - 0 KW - Lead KW - 2P299V784P KW - Nitric Acid KW - 411VRN1TV4 KW - Index Medicus KW - Dust -- analysis KW - Ultrasonics KW - Lead -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77002544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hazardous+materials&rft.atitle=Ultrasonic+extraction+and+field-portable+anodic+stripping+voltammetric+measurement+of+lead+in+dust+wipe+samples.&rft.au=Ashley%2C+K%3BWise%2C+T+J%3BMercado%2C+W%3BParry%2C+D+B&rft.aulast=Ashley&rft.aufirst=K&rft.date=2001-05-07&rft.volume=83&rft.issue=1-2&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+hazardous+materials&rft.issn=03043894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13. AN - 70811354; 11278629 AB - Interleukin-13 (IL-13), a predominantly Th2-derived cytokine, appears to play a central pathological role in asthma, atopic dermatitis, allergic rhinitis, some parasitic infections, and cancer. We hypothesized that an IL-13 antagonist may have profound therapeutic utility in these conditions. We, therefore, mutagenized human IL-13 in which Glu at position 13 was substituted by a Lys residue. This highly purified recombinant IL-13 variant, IL-13E13K, bound with 4-fold higher affinity to the IL-13 receptor than wild-type IL-13 but retained no detectable proliferative activity on the TF-1 hematopoietic cell line. IL-13E13K competitively inhibited IL-13- and IL-4-dependent TF-1 proliferation. It also inhibited IL-13-induced STAT-6 (signal transduction and activator of transducer-6) activation in immune cells and cancer cells and reversed IL-13-induced inhibition of CD14 expression on human primary monocytes. These results demonstrate that high affinity binding and signal generation can be uncoupled efficiently in a ligand receptor interaction. These results also suggest that IL-13E13K may be a useful antagonist for the treatment of allergic, inflammatory, and parasitic diseases or even malignancies in which IL-13 plays a central role. JF - The Journal of biological chemistry AU - Oshima, Y AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2001/05/04/ PY - 2001 DA - 2001 May 04 SP - 15185 EP - 15191 VL - 276 IS - 18 SN - 0021-9258, 0021-9258 KW - Antigens, CD14 KW - 0 KW - Interleukin-13 KW - Interleukin-5 KW - Interleukin-4 KW - 207137-56-2 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Index Medicus KW - Interleukin-5 -- chemistry KW - Models, Molecular KW - Humans KW - Cell Division -- drug effects KW - Amino Acid Sequence KW - Granulocyte-Macrophage Colony-Stimulating Factor -- chemistry KW - Antigens, CD14 -- metabolism KW - Molecular Sequence Data KW - Cytotoxicity, Immunologic -- drug effects KW - Sequence Homology, Amino Acid KW - Down-Regulation -- drug effects KW - Interleukin-4 -- chemistry KW - Cell Line KW - Protein Conformation KW - Interleukin-13 -- chemistry KW - Interleukin-13 -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70811354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Characterization+of+a+powerful+high+affinity+antagonist+that+inhibits+biological+activities+of+human+interleukin-13.&rft.au=Oshima%2C+Y%3BPuri%2C+R+K&rft.aulast=Oshima&rft.aufirst=Y&rft.date=2001-05-04&rft.volume=276&rft.issue=18&rft.spage=15185&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The 2-(N-formyl-N-methyl)aminoethyl group as a potential phosphate/thiophosphate protecting group in solid-phase oligodeoxyribonucleotide synthesis. AN - 70815955; 11348216 AB - [reaction in text] The 2-(N-formyl-N-methyl)aminoethyl deoxyribonucleoside phosphoramidite 1 has been synthesized and used in the solid-phase synthesis of an octadecathymidylic acid as a cost-efficient monomer for potential application in the preparation of therapeutic oligonucleotides. The 2-(N-formyl-N-methyl)aminoethyl group can be cleaved from oligonucleotides according to a unique thermolytic cyclodeesterification process at pH 7.0. In addition to being cost-effective, the use of 1 simplifies oligonucleotide postsynthesis processing by eliminating the utilization of concentrated ammonium hydroxide in oligonucleotide deprotection. JF - Organic letters AU - Grajkowski, A AU - Wilk, A AU - Chmielewski, M K AU - Phillips, L R AU - Beaucage, S L AD - Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA. Y1 - 2001/05/03/ PY - 2001 DA - 2001 May 03 SP - 1287 EP - 1290 VL - 3 IS - 9 SN - 1523-7060, 1523-7060 KW - 2-(N-formyl-N-methyl)aminoethyl deoxythymdine phosphoramidite KW - 0 KW - Hydroxides KW - Oligodeoxyribonucleotides KW - Ammonium Hydroxide KW - 5138Q19F1X KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Phosphoric Diester Hydrolases KW - EC 3.1.4.- KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Molecular Structure KW - Hydroxides -- toxicity KW - Esterification KW - Electrophoresis, Polyacrylamide Gel KW - Hydrogen-Ion Concentration KW - Chromatography, Agarose KW - Hydroxides -- chemistry KW - Alkaline Phosphatase -- metabolism KW - Phosphoric Diester Hydrolases -- metabolism KW - Structure-Activity Relationship KW - Magnetic Resonance Spectroscopy KW - Thymidine -- chemistry KW - Oligodeoxyribonucleotides -- chemistry KW - Oligodeoxyribonucleotides -- chemical synthesis KW - Thymidine -- chemical synthesis KW - Thymidine -- analogs & derivatives KW - Oligodeoxyribonucleotides -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70815955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=The+2-%28N-formyl-N-methyl%29aminoethyl+group+as+a+potential+phosphate%2Fthiophosphate+protecting+group+in+solid-phase+oligodeoxyribonucleotide+synthesis.&rft.au=Grajkowski%2C+A%3BWilk%2C+A%3BChmielewski%2C+M+K%3BPhillips%2C+L+R%3BBeaucage%2C+S+L&rft.aulast=Grajkowski&rft.aufirst=A&rft.date=2001-05-03&rft.volume=3&rft.issue=9&rft.spage=1287&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=15237060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Etiology of foodborne outbreaks AN - 39371206; 3588374 AU - Buchanan, R Y1 - 2001/05/03/ PY - 2001 DA - 2001 May 03 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39371206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Etiology+of+foodborne+outbreaks&rft.au=Buchanan%2C+R&rft.aulast=Buchanan&rft.aufirst=R&rft.date=2001-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The American Association for the Advancement of Science, 1200 New York Ave., Washington, D.C. 20077-1601, USA; URL: www.aaas.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biosolids treatment and disposal modifications at the shoprock wastewater treatment plant AN - 39370405; 3591554 AU - Craney, P Y1 - 2001/05/03/ PY - 2001 DA - 2001 May 03 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39370405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biosolids+treatment+and+disposal+modifications+at+the+shoprock+wastewater+treatment+plant&rft.au=Craney%2C+P&rft.aulast=Craney&rft.aufirst=P&rft.date=2001-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: NSF International, Center for Public Health Education, 789 N. Dixboro Rd., Ann Arbor, MI 48105, USA; phone: 734-913-5789; fax: 734-827-7187/6831; email: conferences@nsf.org. Paper No. 3-1 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Genetic basis for susceptibility to noise-induced hearing loss in mice. AN - 85348715; pmid-11335078 AB - The C57BL/6J (B6) and DBA/2J (D2) inbred strains of mice exhibit an age-related hearing loss (AHL) due to a recessive gene (Ahl) that maps to Chromosome 10. The Ahl gene is also implicated in the susceptibility to noise-induced hearing loss (NIHL). The B6 mice (Ahl/Ahl) are more susceptible to NIHL than the CBA/CaJ (CB) mice (+(Ahl)). The B6xD2.F(1) hybrid mice (Ahl/Ahl) are more susceptible to NIHL than the CBxB6.F(1) mice (+/Ahl) [Erway et al., 1996. Hear. Res. 93, 181-187]. These genetic effects implicate the Ahl gene as contributing to NIHL susceptibility. The present study demonstrates segregation for the putative Ahl gene and mapping of such a gene to Chromosome 10, consistent with other independent mapping of Ahl for AHL in 10 strains of mice [Johnson et al., 2000. Genomics 70, 171-180]. The present study was based on a conventional cross between two inbred strains, CBxB6.F(1) backcrossed to B6 with segregation for the putative +/Ahl:Ahl/Ahl. These backcross progeny were exposed to 110 dB SPL noise for 8 h. All of the progeny were tested for auditory evoked brainstem responses and analyzed for any significant permanent threshold shift of NIHL. Cluster analyses were used to distinguish the two putative genotypes, the least affected with NIHL (+/Ahl) and most affected with PTS (Ahl/Ahl). Approximately 1/2 of the backcross progeny exhibited PTS, particularly at 16 kHz. These mice were genotyped for two D10Mit markers. Quantitative trait loci analyses (log of the odds=15) indicated association of the genetic factor within a few centiMorgan of the best evidence for Ahl [Johnson et al., 2000. Genomics 70, 171-180]. All of the available evidence supports a role for the Ahl gene in both AHL and NIHL among these strains of mice. JF - Hearing research AU - Davis, R R AU - Newlander, J K AU - Ling, X AU - Cortopassi, G A AU - Krieg, E F AU - Erway, L C AD - Hearing Loss Prevention Section, Division of Applied Research and Technology, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, Mailstop C-27, 4676 Columbia Parkway, Cincinnati OH 45226, USA. rrdl@cdc.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 82 EP - 90 VL - 155 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Auditory Threshold KW - Crosses, Genetic KW - Evoked Potentials, Auditory, Brain Stem KW - Female KW - Genotype KW - *Hearing Loss, Noise-Induced: genetics KW - Hearing Loss, Noise-Induced: physiopathology KW - Hybridization, Genetic KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Inbred CBA KW - Mice, Inbred DBA KW - Phenotype KW - Species Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85348715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Genetic+basis+for+susceptibility+to+noise-induced+hearing+loss+in+mice.&rft.au=Davis%2C+R+R%3BNewlander%2C+J+K%3BLing%2C+X%3BCortopassi%2C+G+A%3BKrieg%2C+E+F%3BErway%2C+L+C&rft.aulast=Davis&rft.aufirst=R&rft.date=2001-05-01&rft.volume=155&rft.issue=1-2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Comparative pulmonary toxicity of 6 abrasive blasting agents. AN - 77037433; 11294984 AB - Inhalation of silica dust is associated with pulmonary fibrosis. Therefore, substitute abrasive materials have been suggested for use in abrasive blasting operations. To date, toxicological evaluation of most substitute abrasives has been incomplete. Therefore, the objective of this study was to compare the pulmonary toxicity of a set of substitute abrasives (garnet, staurolite, coal slag, specular hematite, and treated sand) to that of blasting sand. Rats were exposed to blasting sand or an abrasive substitute by intratracheal instillation and pulmonary responses to exposure were monitored 4 weeks postexposure. Pulmonary damage was monitored as lactate dehydrogenase (LDH) in the acellular lavage fluid. Pulmonary inflammation was evaluated from the yield of polymorphonuclear leukocytes (PMN) obtained by bronchoalveolar lavage. The activity of alveolar macrophages was determined by measuring zymosan-stimulated chemiluminescence. Blasting sand caused lung damage and showed histologic evidence for inflammation and fibrosis. Garnet, staurolite, and treated sand exhibited toxicity and inflammation that were similar to blasting sand, while coal slag caused greater pulmonary damage and inflammation than blasting sand. In contrast, specular hematite did not significantly elevate LDH or PMN levels and did not stimulate macrophage activity 4 weeks postexposure. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Hubbs, A F AU - Minhas, N S AU - Jones, W AU - Greskevitch, M AU - Battelli, L A AU - Porter, D W AU - Goldsmith, W T AU - Frazer, D AU - Landsittel, D P AU - Ma, J Y AU - Barger, M AU - Hill, K AU - Schwegler-Berry, D AU - Robinson, V A AU - Castranova, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. afh0@cdc.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 135 EP - 143 VL - 61 IS - 1 SN - 1096-6080, 1096-6080 KW - Coal KW - 0 KW - Ferric Compounds KW - Minerals KW - staurolite KW - 12182-56-8 KW - ferric oxide KW - 1K09F3G675 KW - Silicon Dioxide KW - 7631-86-9 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Neutrophils -- pathology KW - Macrophages, Alveolar -- enzymology KW - Neutrophils -- enzymology KW - Macrophages, Alveolar -- pathology KW - Male KW - Microscopy, Electron, Scanning KW - Coal -- toxicity KW - Silicon Dioxide -- analysis KW - Minerals -- toxicity KW - Ferric Compounds -- toxicity KW - L-Lactate Dehydrogenase -- chemistry KW - Lung -- cytology KW - Silicon Dioxide -- toxicity KW - Coal -- analysis KW - Minerals -- analysis KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Pulmonary Fibrosis -- pathology KW - Ferric Compounds -- analysis KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- enzymology KW - Lung -- enzymology KW - Bronchoalveolar Lavage Fluid -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77037433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparative+pulmonary+toxicity+of+6+abrasive+blasting+agents.&rft.au=Hubbs%2C+A+F%3BMinhas%2C+N+S%3BJones%2C+W%3BGreskevitch%2C+M%3BBattelli%2C+L+A%3BPorter%2C+D+W%3BGoldsmith%2C+W+T%3BFrazer%2C+D%3BLandsittel%2C+D+P%3BMa%2C+J+Y%3BBarger%2C+M%3BHill%2C+K%3BSchwegler-Berry%2C+D%3BRobinson%2C+V+A%3BCastranova%2C+V&rft.aulast=Hubbs&rft.aufirst=A&rft.date=2001-05-01&rft.volume=61&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Flow cytometric detection of pathogenic E. coli in food. AN - 71396057; 18770690 AB - E. coli O157:H7 is one of the more important food pathogens, andrapid, quantitative methods to evaluate foods for the presence of this pathogen are needed. This unit provides exactly that: a very much simplified flow cytometric assay for detection of E. coli O157:H7 in a well established vehicle of infection, ground beef. The method uses commercially available FITC-conjugated specific antibody to this bacterial serotype. Sample preparation and bacterial enrichment procedures are described. Direct and indirect approaches for quantification of the number of bacteria are given. A key feature of the assay is the reduction in time compared with plate-counting methods; the tradeoff is a slight reduction in sensitivity. Particularly useful is the simultaneous inclusion of a spiked sample to ensure a positive control. In addition, the unit provides hints on sorting the organisms if desired. JF - Current protocols in cytometry AU - Raybourne, R B AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition Laurel, Maryland, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 VL - Chapter 11 KW - Antibodies KW - 0 KW - Fluorescent Dyes KW - Index Medicus KW - Animals KW - Cattle KW - Reproducibility of Results KW - Calibration KW - Fluorescent Dyes -- chemistry KW - Flow Cytometry -- methods KW - Cell Separation -- methods KW - Food Microbiology KW - Food Contamination KW - Meat -- microbiology KW - Escherichia coli O157 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71396057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+cytometry&rft.atitle=Flow+cytometric+detection+of+pathogenic+E.+coli+in+food.&rft.au=Raybourne%2C+R+B&rft.aulast=Raybourne&rft.aufirst=R&rft.date=2001-05-01&rft.volume=Chapter+11&rft.issue=&rft.spage=Unit+11.6&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+cytometry&rft.issn=1934-9300&rft_id=info:doi/10.1002%2F0471142956.cy1106s08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/0471142956.cy1106s08 ER - TY - JOUR T1 - Gender-based differences in rats after chronic dietary exposure to genistein. AN - 71066121; 11488560 AB - Gender-based differences can be observed from pharmacokinetic, behavioral, or anatomical assessments. No single assessment tool will provide a complete answer, but the use of a variety of indices, each with known gender-related outcome differences, can reveal agent-induced gender-based alterations. In a series of initial range-finding studies in rats conducted at the National Center for Toxicological Research (NCTR), the effects of dietary exposure to the weak estrogen, genistein, have been assessed using a number of techniques with validated gender-related outcome measures. The findings indicated that (1) the internal dose of genistein was higher in females than males after equivalent dietary exposure and this was consistent with the faster rate of genistein elimination in males; (2) in behavioral assessments, males and females in the high-dose dietary genistein group consumed more of a sodium-flavored solution; however, no genistein-related changes were observed in open field or running wheel activity, play behavior, or intake of a saccharin-flavored solution; and (3) dose-related alterations of the volume of the sexually dimorphic nucleus of the medial preoptic area were observed in genistein-exposed male rats but not females. These observations describe the utility of a variety of gender-based assessment tools and indicate that dose-related effects of developmental and chronic dietary exposure to genistein can be observed in the rodent. Additional studies, perhaps in nonhuman primates, are necessary to further predict the effect(s) of genistein on human gender-based development. JF - International journal of toxicology AU - Slikker, W AU - Scallet, A C AU - Doerge, D R AU - Ferguson, S A AD - Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA. wslikker@nctr.fda.gov PY - 2001 SP - 175 EP - 179 VL - 20 IS - 3 SN - 1091-5818, 1091-5818 KW - Enzyme Inhibitors KW - 0 KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Sprague-Dawley KW - Sex Factors KW - Sex Characteristics KW - Preoptic Area -- physiology KW - Dose-Response Relationship, Drug KW - Preoptic Area -- drug effects KW - Diet KW - Taste KW - Male KW - Female KW - Enzyme Inhibitors -- adverse effects KW - Behavior, Animal -- drug effects KW - Genistein -- pharmacology KW - Genistein -- adverse effects KW - Enzyme Inhibitors -- pharmacology KW - Enzyme Inhibitors -- pharmacokinetics KW - Genistein -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71066121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+toxicology&rft.atitle=Gender-based+differences+in+rats+after+chronic+dietary+exposure+to+genistein.&rft.au=Slikker%2C+W%3BScallet%2C+A+C%3BDoerge%2C+D+R%3BFerguson%2C+S+A&rft.aulast=Slikker&rft.aufirst=W&rft.date=2001-05-01&rft.volume=20&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=International+journal+of+toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-08-07 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Gender-based differences in the toxicity of pharmaceuticals--the Food and Drug Administration's perspective. AN - 71065998; 11488556 AB - Women experience more adverse reactions to treatment with therapeutic drugs than men. Theories proposed to explain this include overdosing, different pharmacokinetics and pharmacodynamics, women are more likely to report adverse events than men, or women take more medications than men. Food and Drug Administration (FDA) Office of Women's Health (OWH) funds research to promote including women in clinical trials and understanding the biology of sex-related differences in the safety of FDA-regulated products. Including women in clinical trials advances the understanding of drug efficacy and safety in women by providing information on drug dosing, pharmacokinetics, and pharmacodynamics. A Baysian statistical analysis of sex differences in adverse events showed that although about the same number of adverse events were reported for men and women, those reported for women were more serious. One example of a sex difference in the toxicity of pharmaceuticals is the drug-induced cardiac arrhythmia, torsades de point. OWH funded studies in animals and humans to investigate the mechanism behind this sex difference. These studies demonstrated that shortening the QT interval increases the risk of developing torsades and that androgens protect against torsades by slowing cardiac repolarization and prolonging the QT interval. Understanding the mechanisms behind other reported sex-related differences in adverse drug effects requires additional research. The preliminary studies conducted to date suggest that this sex-related difference is likely to be a multifactorial problem requiring information from several fields of study. Ideally, individuals at risk for developing an adverse event should be identified prior to therapeutic intervention. The OWH plans to fund more studies to investigate the role of hormonal variations on drug metabolism and drug-drug interactions. Animal and in vitro model systems are needed to fully understand the mechanism of how gender influences drug toxicity. JF - International journal of toxicology AU - Miller, M A AD - Office of Women's Health, Food and Drug Administration, Rockville, Maryland 20857, USA. MMILLER1@OC.FDA.GOV PY - 2001 SP - 149 EP - 152 VL - 20 IS - 3 SN - 1091-5818, 1091-5818 KW - Androgens KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Sex Factors KW - Risk Factors KW - Humans KW - Clinical Trials as Topic KW - Health Policy KW - Androgens -- pharmacology KW - Research Design KW - Women's Health KW - Drug-Related Side Effects and Adverse Reactions KW - Torsades de Pointes -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71065998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+toxicology&rft.atitle=Gender-based+differences+in+the+toxicity+of+pharmaceuticals--the+Food+and+Drug+Administration%27s+perspective.&rft.au=Miller%2C+M+A&rft.aulast=Miller&rft.aufirst=M&rft.date=2001-05-01&rft.volume=20&rft.issue=3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=International+journal+of+toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-08-07 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Fatal on-farm injuries among youth 16 to 19 years of age: 1982-1994. AN - 71023817; 11465385 AB - Data from the Vital Statistics Mortality (VSM) public use file and the National Traumatic Occupational Fatalities (NTOF) surveillance systems were used to describe fatal injuries among youth 16-19 years of age in the United States that occurred on farms for the years 1982 through 1994. The VSM captures all deaths in the United States, while the NTOF only captures occupational injury deaths. There were 550 total on-farm fatalities to youth 16-19 years of age in the VSM, and 221 occupational on-farm deaths from the NTOF for the same age group. These numbers suggest that 40% of the on-farm deaths were occupational. It was found that the proportions of deaths attributable to work increased with age. Fatality rates for on-farm nonoccupational deaths decreased slightly during the time period (from 8.4 deaths/100,000 for 1982-1985 to 6.8 deaths/100,000 for 1991-1994), while on-farm occupational fatality rates dropped dramatically (12.0 deaths/100,000 for 1982-1985 down to 4.9 deaths/100,000 for 1991-1994). The leading causes of death for on-farm occupational fatalities were machinery (54%) and electrical current (20%). The most common causes of on-farm fatalities that were nonoccupational were drowning (38.9%) and firearms (28.6%). For the years 1991 through 1994, drowning and firearms accounted for approximately the same number of on-farm deaths as machinery. Nonoccupational risks are a concern for youth 16-19 years of age on the farm. JF - Journal of agricultural safety and health AU - Myers, J R AU - Adekoya, N AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. jom5@cdc.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 101 EP - 112 VL - 7 IS - 2 SN - 1074-7583, 1074-7583 KW - Index Medicus KW - Age Factors KW - Rural Population KW - Accidents, Occupational -- trends KW - Occupational Health -- statistics & numerical data KW - Humans KW - Adult KW - Accidents, Occupational -- mortality KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Cause of Death KW - Population Surveillance KW - Accidents -- trends KW - Accidents -- mortality KW - Agriculture -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71023817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+safety+and+health&rft.atitle=Fatal+on-farm+injuries+among+youth+16+to+19+years+of+age%3A+1982-1994.&rft.au=Myers%2C+J+R%3BAdekoya%2C+N&rft.aulast=Myers&rft.aufirst=J&rft.date=2001-05-01&rft.volume=7&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+safety+and+health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An evaluation of short-term exposures to metalworking fluids in small machine shops. AN - 70966750; 11434440 AB - In a study of 23 small machining shops using metalworking fluids (MWFs), real-time air monitoring using an aerosol photometer was performed to investigate the temporal nature of the exposure and to examine the relationship between the instrumental measurements and traditional sampling methods. Time-weighted averages were calculated from the aerosol photometer data and the results were compared to collocated thoracic and 37-mm closed face cassette samplers. The filter samples were analyzed for total mass and the solvent extractable fraction. Depending on the averaging period used, short-term MWF concentrations exceeded 2.0 mg/m3 in 13 to 39% of the plants studied. High short-term exposures were as likely to be found in plants with average concentrations below 0.4 mg/m3 (thoracic-gravimetric) as those above. Regression analyses indicated that the aerosol photometer most closely matched the data obtained from the thoracic fraction of the total mass. In general, the aerosol photometer overestimated the levels determined using the thoracic cyclone and filter, especially when measuring concentrations of water-based fluids. Use of a calibration factor of 0.7 for straight oils or 0.5 for water-based fluids may assist in the interpretation of aerosol photometer measurements if field calibration data are not readily available. Several approaches to determining the calibration factor from field data were evaluated; more complex calibration techniques improved the accuracy of the measurements. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - O'Brien, D M AU - Piacitelli, G M AU - Sieber, W K AU - Hughes, R T AU - Catalano, J D AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. PY - 2001 SP - 342 EP - 348 VL - 62 IS - 3 SN - 1529-8663, 1529-8663 KW - Aerosols KW - 0 KW - Hazardous Substances KW - Index Medicus KW - Regression Analysis KW - Particle Size KW - Time Factors KW - Industrial Oils -- analysis KW - Hazardous Substances -- adverse effects KW - Occupational Exposure -- adverse effects KW - Occupational Exposure -- analysis KW - Metallurgy KW - Hazardous Substances -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70966750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=An+evaluation+of+short-term+exposures+to+metalworking+fluids+in+small+machine+shops.&rft.au=O%27Brien%2C+D+M%3BPiacitelli%2C+G+M%3BSieber%2C+W+K%3BHughes%2C+R+T%3BCatalano%2C+J+D&rft.aulast=O%27Brien&rft.aufirst=D&rft.date=2001-05-01&rft.volume=62&rft.issue=3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of allantoin, uric acid, and indoxyl sulfate as biochemical indicators of filth in food packaging by LC. AN - 70962237; 11417643 AB - A liquid chromatographic (LC) method was developed for the determination of allantoin, uric acid, and indoxyl sulfate in mammalian urine contaminated packaging material including paper bagging, corrugated cardboard, grayboard, and burlap bagging. The procedure involves solvent extraction and isolation of the 3 analytes by reversed-phase LC with ultraviolet detection at 225 nm for allantoin and 286 nm for uric acid and indoxyl sulfate. The composition of authentic mammalian urine such as mouse, rat, cat, dog, and human were also determined with regard to the 3 compounds of interest. A linear concentration range of 0.11-20.4, 0.02-10.0, and 0.04-30.0 microg/mL was obtained for allantoin, uric acid, and indoxyl sulfate, respectively. Limits of detection (LOD) and quantitation (LOQ) were 0.0104 and 0.0345 microg/mL for allantoin; 0.0018 and 0.0060 microg/mL for uric acid; and 0.0049 and 0.0165 microg/mL for indoxyl sulfate, respectively. Interday relative standard deviation values for a mixture of standard allantoin, uric acid, and indoxyl sulfate (n = 5) were 0.97, 0.80, and 0.94%, respectively. Analyte composition for 5 types of authentic mammalian urine varied from 0.19-6.88 mg/mL allantoin; 0.08-0.57 mg/mL uric acid; and 0.03-0.78 mg/mL indoxyl sulfate. Analyte content for 8 samples including 2 samples each for paper, cardboard, grayboard, and burlap bagging each contaminated with mouse or rat urine ranged from 100,000 recovery records in 13 databases was 94%. The overall average single-value relative standard deviation (RSD) of the reported recoveries was 17% at a mean concentration (C) of about 10(-7) (0.1 mg/kg). The average apparent HORRAT value (RSD found/RSDR predicted from the Horwitz formula [2*C(-0.1505)]) was 0.8. Analysis of variance indicated that about 60-70% of the variance could not be associated with any particular factor or combination of factors-analyte, commodity, method, laboratory, concentration, database, or their interactions. The most predominant factor, analyte, and its third-order interaction with laboratory and concentration contributed most of the assignable variance. These findings suggested that most of the variability of trace analysis for pesticide residues is "random" in the sense of being inherent and not assignable to specific factor fluctuations. JF - Journal of AOAC International AU - Horwitz, W AU - Jackson, T AU - Chirtel, S J AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA. Whorwitz@aoac.org PY - 2001 SP - 919 EP - 935 VL - 84 IS - 3 SN - 1060-3271, 1060-3271 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - United States KW - California KW - Vegetables KW - Analysis of Variance KW - Fruit KW - United States Department of Agriculture KW - Quality Control KW - Laboratories -- standards KW - Food Analysis -- standards KW - Pesticide Residues -- analysis KW - Crops, Agricultural -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70933910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Examination+of+proficiency+and+control+recovery+data+from+analyses+for+pesticide+residues+in+food%3A+sources+of+variability.&rft.au=Horwitz%2C+W%3BJackson%2C+T%3BChirtel%2C+S+J&rft.aulast=Horwitz&rft.aufirst=W&rft.date=2001-05-01&rft.volume=84&rft.issue=3&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of lead and cadmium in ceramicware leach solutions by graphite furnace atomic absorption spectroscopy: method development and interlaboratory trial. AN - 70925828; 11417650 AB - This method was developed to improve sensitivity and eliminate time consuming, evaporative pre-concentration in AOAC Method 973.82 and American Society for Testing and Materials method C738 for testing foodware. The method was developed using leach solutions obtained by leaching 9 differently decorated ceramic vessels with 4% acetic acid for 24 h at room temperature. Lead and cadmium concentrations in leach solutions were 0.005-17,600 and 0.0004-0.500 microg/mL, respectively. Concentrations were determined using peak area, phosphate chemical modifier (8.3 microg PO4(-3)), and a standard curve for quantitation. Optimized pre-atomization and atomization temperatures were 1,300 and 1,800 degrees C, respectively, for Pb and 1,100 and 1,700 degrees C, respectively, for Cd. Characteristic masses (mo) were 10 and 0.4 pg for Pb and Cd, respectively. Precision of repeated analyses of calibration solutions was < or =3% relative standard deviation. Precision of duplicate leach solution analyses on different days was 0-9% relative difference. Recovery from fortified leach solutions was 96-106%. Results obtained by this method agreed 92-110% with those of confirmatory analyses. Results of certified reference material solutions agreed 94-100% with certificate values. Pb and Cd limits of quantitation (LOQ) were 0.005 and 0.0005 microg/mL, respectively. Results from 3 trial laboratories for 4 leach solutions containing Pb and Cd concentrations of 0.017-1.47 and <0.0005-0.0864 microg/mL, respectively, agreed 89-102% with results of the author. Two attributes of this method were noteworthy: (1) Background absorbance due to organic matter was entirely absent from atomization profiles, making the use of short pre-atomization hold times (2 s) possible. (2) Instrument precision was excellent and only one determination per solution was needed. Acceptance criteria for quality control measurements and a practical procedure for estimating the method LOQ during routine regulatory analyses are described. JF - Journal of AOAC International AU - Hight, S C AD - US Food and Drug Administration, HFS 338, Center for Food and Safety and Applied Nutrition, Washington, DC 20204, USA. PY - 2001 SP - 861 EP - 872 VL - 84 IS - 3 SN - 1060-3271, 1060-3271 KW - Solutions KW - 0 KW - Cadmium KW - 00BH33GNGH KW - Lead KW - 2P299V784P KW - Acetic Acid KW - Q40Q9N063P KW - Index Medicus KW - Solutions -- analysis KW - Sensitivity and Specificity KW - Food Contamination -- prevention & control KW - Quality Control KW - Spectrophotometry, Atomic -- methods KW - Cadmium -- analysis KW - Ceramics -- analysis KW - Cooking and Eating Utensils KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70925828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+lead+and+cadmium+in+ceramicware+leach+solutions+by+graphite+furnace+atomic+absorption+spectroscopy%3A+method+development+and+interlaboratory+trial.&rft.au=Hight%2C+S+C&rft.aulast=Hight&rft.aufirst=S&rft.date=2001-05-01&rft.volume=84&rft.issue=3&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of gene expression induced by irritant and sensitizing chemicals using oligonucleotide arrays. AN - 70890624; 11379042 AB - Chemical-induced allergy continues to be an important occupational health problem. Despite decades of investigation, the molecular mechanisms underlying chemical-induced hypersensitivity and irritancy remain unclear because of the complex interplay between properties of different chemicals and the immune system. In this study, gene expression induced by toluene diisocyanate (TDI, a primarily IgE-inducing sensitizer), oxazolone (OXA, a cell-mediated hypersensitivity inducing sensitizer), or nonanoic acid (NA, a non-sensitizing irritant) was investigated using gene arrays. Female BALB/c mice were dermally exposed on the ears once daily for 4 consecutive days. On day 5, the lymph nodes draining the exposure sites were collected and used for RNA extraction and subsequent hybridization to Affymetrix Mu6500 oligonucleotide arrays. Of the 6519 genes on the arrays, there were 44, 13, and 51 genes in the TDI-, OXA-, and NA-exposed samples, respectively, that displayed a minimum of twofold change in expression level relative to the vehicle control. There were 32, 19, and 19 genes that were differentially expressed (with a minimum of twofold change) between TDI and OXA, TDI and NA, OXA and NA, respectively. The differentially expressed genes include immune response-related genes, transcriptional factors, signal transducing molecules, and Expressed Sequence Tags. Based on the gene array results, candidate genes were further evaluated using RT-PCR. There was only about 47% concordance between the gene array and RT-PCR results. JF - International immunopharmacology AU - He, B AU - Munson, A E AU - Meade, B J AD - National Institute for Occupational Safety and Health, Office of the Director, Morgantown, WV 26505, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 867 EP - 879 VL - 1 IS - 5 SN - 1567-5769, 1567-5769 KW - Fatty Acids KW - 0 KW - Irritants KW - Oxazolone KW - 15646-46-5 KW - Toluene 2,4-Diisocyanate KW - 17X7AFZ1GH KW - pelargonic acid KW - 97SEH7577T KW - Index Medicus KW - Animals KW - Oxazolone -- toxicity KW - Toluene 2,4-Diisocyanate -- toxicity KW - Humans KW - Hypersensitivity -- etiology KW - Occupational Diseases -- etiology KW - Mice KW - Fatty Acids -- toxicity KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Inbred BALB C KW - Immunization KW - Female KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Irritants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70890624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+immunopharmacology&rft.atitle=Analysis+of+gene+expression+induced+by+irritant+and+sensitizing+chemicals+using+oligonucleotide+arrays.&rft.au=He%2C+B%3BMunson%2C+A+E%3BMeade%2C+B+J&rft.aulast=He&rft.aufirst=B&rft.date=2001-05-01&rft.volume=1&rft.issue=5&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=International+immunopharmacology&rft.issn=15675769&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-12 N1 - Date created - 2001-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of leucocyanidines on activities of metabolizing enzymes and antioxidant enzymes. AN - 70877362; 11379789 AB - Procyanidolic oligomers (leucocyanidines, LCs) extracted from grape seeds (Vitis vinifera) are known to have antioxidant and antimutagenic activities, and a protective effect against cardiovascular disease. In the present study we examined the influence of LCs on the activities of phase 1 enzymes and conjugation enzymes and on antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Administration of LCs (25, 50, and 100 mg/kg. p.o. for 7 d) markedly decreased the activities of NADPH-cytochrome P450 reductase, P4501A1, P4501A2, and P4503A4, but significantly increased the activities of glutathione S-transferase and phenolsulfotransferase in rat liver. However, the activities of antioxidant enzymes were not affected by LC administration. The inhibition of P450s and increases in phase II enzyme activities indicate a role for LCs as a chemopreventive agent against toxic or carcinogenic metabolites of P450 isozymes. JF - Biological & pharmaceutical bulletin AU - Seo, K AU - Jung, S AU - Park, M AU - Song, Y AU - Choung, S AD - Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, Eunpyunggu, Seoul, Korea. kwseo@kfda.go.kr Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 592 EP - 593 VL - 24 IS - 5 SN - 0918-6158, 0918-6158 KW - Antimutagenic Agents KW - 0 KW - Antioxidants KW - Cytochrome P-450 Enzyme Inhibitors KW - Flavonoids KW - Phenols KW - Polymers KW - Polyphenols KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Rats KW - Catalase -- metabolism KW - Animals KW - Seeds -- chemistry KW - Rats, Sprague-Dawley KW - Glutathione Peroxidase -- metabolism KW - Superoxide Dismutase -- metabolism KW - Male KW - Antimutagenic Agents -- pharmacology KW - Polymers -- pharmacology KW - Antioxidants -- pharmacology KW - Phenols -- pharmacology KW - Rosales -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70877362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+%26+pharmaceutical+bulletin&rft.atitle=Effects+of+leucocyanidines+on+activities+of+metabolizing+enzymes+and+antioxidant+enzymes.&rft.au=Seo%2C+K%3BJung%2C+S%3BPark%2C+M%3BSong%2C+Y%3BChoung%2C+S&rft.aulast=Seo&rft.aufirst=K&rft.date=2001-05-01&rft.volume=24&rft.issue=5&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Biological+%26+pharmaceutical+bulletin&rft.issn=09186158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-27 N1 - Date created - 2001-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An assessment of thimerosal use in childhood vaccines. AN - 70869512; 11331700 AB - On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from the Food and Drug Administration that is presented here. The risk assessment consisted of hazard identification, dose-response assessment, exposure assessment, and risk characterization. The literature was reviewed to identify known toxicity of thimerosal, ethylmercury (a metabolite of thimerosal) and methylmercury (a similar organic mercury compound) and to determine the doses at which toxicity occurs. Maximal potential exposure to mercury from vaccines was calculated for children at 6 months old and 2 years, under the US childhood immunization schedule, and compared with the limits for mercury exposure developed by the Environmental Protection Agency (EPA), the Agency for Toxic Substance and Disease Registry, the Food and Drug Administration, and the World Health Organization. Delayed-type hypersensitivity reactions from thimerosal exposure are well-recognized. Identified acute toxicity from inadvertent high-dose exposure to thimerosal includes neurotoxicity and nephrotoxicity. Limited data on toxicity from low-dose exposures to ethylmercury are available, but toxicity may be similar to that of methylmercury. Chronic, low-dose methylmercury exposure may cause subtle neurologic abnormalities. Depending on the immunization schedule, vaccine formulation, and infant weight, cumulative exposure of infants to mercury from thimerosal during the first 6 months of life may exceed EPA guidelines. Our review revealed no evidence of harm caused by doses of thimerosal in vaccines, except for local hypersensitivity reactions. However, some infants may be exposed to cumulative levels of mercury during the first 6 months of life that exceed EPA recommendations. Exposure of infants to mercury in vaccines can be reduced or eliminated by using products formulated without thimerosal as a preservative. JF - Pediatrics AU - Ball, L K AU - Ball, R AU - Pratt, R D AD - Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Foodand Drug Administration, Rockville, Maryland 20852, USA. balll@cber.fda.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1147 EP - 1154 VL - 107 IS - 5 KW - Methylmercury Compounds KW - 0 KW - Preservatives, Pharmaceutical KW - Vaccines KW - Thimerosal KW - 2225PI3MOV KW - Mercury KW - FXS1BY2PGL KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Immunization -- adverse effects KW - Methylmercury Compounds -- toxicity KW - Child, Preschool KW - Risk Assessment KW - Infant KW - Mercury Poisoning -- etiology KW - United States Food and Drug Administration KW - Hypersensitivity, Delayed KW - Methylmercury Compounds -- adverse effects KW - Guidelines as Topic KW - Mercury Poisoning -- epidemiology KW - Vaccines -- adverse effects KW - Thimerosal -- adverse effects KW - Mercury -- blood KW - Thimerosal -- toxicity KW - Preservatives, Pharmaceutical -- toxicity KW - Preservatives, Pharmaceutical -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70869512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=An+assessment+of+thimerosal+use+in+childhood+vaccines.&rft.au=Ball%2C+L+K%3BBall%2C+R%3BPratt%2C+R+D&rft.aulast=Ball&rft.aufirst=L&rft.date=2001-05-01&rft.volume=107&rft.issue=5&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pediatrics. 2001 May;107(5):1177-8 [11331704] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat. AN - 70858109; 11359700 AB - Fumonisin B1(FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ppm or higher concentrations induced renal tubule carcinomas in male F344/N/Nctr BR rats and hepatocellular carcinomas in female B6C3F1/Nctr BR mice. The carcinogenicity of FB1 in rats and mice is not due to DNA damage, as several laboratories have demonstrated that FB1 is not a genotoxin. FB1 induces apoptosis in cells in vitro. Including FB1 in the diets of rats results in increased hepatocellular and renal tubule epithelial cell apoptosis. In studies with F344/N/Nctr BR rats consuming diets containing up to 484 ppm FB1 for 28 days, female rats demonstrated more sensitivity than male rats in the induction of hepatocellular apoptosis and mitosis. Conversely, induction of renal tubule apoptosis and regeneration were more pronounced in male than in female rats. Induction of renal tubule apoptosis and hyperplasia correlated with the incidence of renal tubule carcinomas that developed in the 2-year feeding study with FB1 in the F344/N/Nctr BR rats. The data are consistent with the hypothesis that the induction of renal tubule carcinomas in male rats could be partly due to the continuous compensatory regeneration of renal tubule epithelial cells in response to the induction of apoptosis by fumonisin B1. JF - Environmental health perspectives AU - Howard, P C AU - Warbritton, A AU - Voss, K A AU - Lorentzen, R J AU - Thurman, J D AU - Kovach, R M AU - Bucci, T J AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. phoward@nctr.fda.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 309 EP - 314 VL - 109 Suppl 2 SN - 0091-6765, 0091-6765 KW - Carboxylic Acids KW - 0 KW - Carcinogens, Environmental KW - Fumonisins KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Animals KW - Hepatocytes -- drug effects KW - Biological Assay KW - Kidney Tubules -- physiopathology KW - Epithelium -- drug effects KW - Cell Survival KW - Rats KW - Epithelium -- physiopathology KW - Rats, Inbred F344 KW - Kidney Tubules -- drug effects KW - Apoptosis -- drug effects KW - Mitosis -- drug effects KW - Female KW - Male KW - Organ Size -- drug effects KW - Kidney Neoplasms -- chemically induced KW - Kidney -- physiology KW - Kidney -- drug effects KW - Liver Neoplasms, Experimental -- physiopathology KW - Liver Neoplasms, Experimental -- chemically induced KW - Regeneration -- drug effects KW - Kidney Neoplasms -- physiopathology KW - Carcinogens, Environmental -- toxicity KW - Mycotoxins -- toxicity KW - Carboxylic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70858109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Compensatory+regeneration+as+a+mechanism+for+renal+tubule+carcinogenesis+of+fumonisin+B1+in+the+F344%2FN%2FNctr+BR+rat.&rft.au=Howard%2C+P+C%3BWarbritton%2C+A%3BVoss%2C+K+A%3BLorentzen%2C+R+J%3BThurman%2C+J+D%3BKovach%2C+R+M%3BBucci%2C+T+J&rft.aulast=Howard&rft.aufirst=P&rft.date=2001-05-01&rft.volume=109+Suppl+2&rft.issue=&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-05-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1990 Dec;11(12):2245-51 [2265476] Int J Cancer. 1980 Jan 15;25(1):137-9 [6105134] Carcinogenesis. 1991 Jul;12(7):1247-51 [1649015] J Biol Chem. 1991 Aug 5;266(22):14486-90 [1860857] Mycopathologia. 1991 Nov;116(2):97-104 [1780003] Carcinogenesis. 1992 Mar;13(3):433-7 [1547534] Toxicol Appl Pharmacol. 1992 May;114(1):9-15 [1585377] Food Chem Toxicol. 1992 Mar;30(3):233-7 [1618447] Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):327-31 [8419937] Int J Cancer. 1984 Sep 15;34(3):383-7 [6480156] Toxicol Appl Pharmacol. 1987 Nov;91(2):182-92 [2445051] Int J Cancer. 1987 Nov 15;40(5):643-5 [3679591] S Afr Med J. 1988 Aug 6;74(3):110-4 [3399988] Carcinogenesis. 1988 Aug;9(8):1405-9 [2900086] Appl Environ Microbiol. 1988 Jul;54(7):1806-11 [2901247] Toxicol Appl Pharmacol. 1989 Dec;101(3):414-31 [2481346] Toxicol Appl Pharmacol. 1990 May;103(3):539-48 [1692643] J Natl Cancer Inst. 1990 Sep 5;82(17):1407-11 [2388291] Crit Rev Toxicol. 1990;20(5):311-26 [2202324] J Biol Chem. 1994 Feb 4;269(5):3475-81 [8106389] J Nutr. 1994 Apr;124(4):594-603 [8145083] Appl Environ Microbiol. 1994 May;60(5):1626-9 [8017941] Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11413-6 [7972075] Carcinogenesis. 1995 Feb;16(2):343-8 [7859367] Fundam Appl Toxicol. 1994 Nov;23(4):562-8 [7532604] Nat Genet. 1995 Jan;9(1):70-4 [7704028] Fundam Appl Toxicol. 1995 Jan;24(1):102-10 [7713333] J Biol Chem. 1995 Jul 7;270(27):16409-14 [7608212] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):461-4 [8552661] Toxicol Lett. 1995 Dec;82-83:15-21 [8597044] Carcinogenesis. 1996 Feb;17(2):239-49 [8625445] Toxicol Appl Pharmacol. 1996 Jun;138(2):211-8 [8658522] Nat Toxins. 1996;4(1):3-15 [8680751] Nat Toxins. 1996;4(1):16-23 [8680749] Biochem J. 1996 Aug 15;318 ( Pt 1):1-14 [8761444] Adv Exp Med Biol. 1996;392:237-50 [8850621] Am J Pathol. 1997 Jan;150(1):43-50 [9006320] Toxicol Appl Pharmacol. 1997 Jan;142(1):208-25 [9007051] Cancer Lett. 1996 Dec 3;109(1-2):101-8 [9020908] J Biol Chem. 1997 Mar 7;272(10):6097-100 [9045618] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3990-3 [9108092] Mutat Res. 1997 Jun 13;391(1-2):39-48 [9219547] J Biol Chem. 1997 Nov 14;272(46):29301-8 [9361010] Toxicol Appl Pharmacol. 1998 Feb;148(2):252-60 [9473533] Int J Oncol. 1999 May;14(5):833-43 [10200332] Carcinogenesis. 1999 May;20(5):817-24 [10334199] Nature. 1961 Mar 11;189:858 [13780066] Nature. 1959 May 28;186:698-700 [13848374] Environ Health Perspect. 2001 May;109 Suppl 2:259-66 [11359694] Environ Health Perspect. 2001 May;109 Suppl 2:277-82 [11359696] Cancer Res. 1991 Jul 1;51(13):3512-21 [1711412] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Excessive noise levels in laboratory work spaces produced by the heating, ventilating, and air conditioning systems. AN - 70856738; 11370927 JF - Applied occupational and environmental hygiene AU - Tubbs, R L AD - Hazard Evaluation and Technical Assistance Branch of the National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 497 EP - 501 VL - 16 IS - 5 SN - 1047-322X, 1047-322X KW - Index Medicus KW - United States KW - Humans KW - Facility Design and Construction -- standards KW - Environmental Monitoring -- standards KW - Organizational Case Studies KW - Environmental Monitoring -- methods KW - Ventilation KW - Heating KW - Laboratories KW - Air Conditioning KW - Noise, Occupational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70856738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Excessive+noise+levels+in+laboratory+work+spaces+produced+by+the+heating%2C+ventilating%2C+and+air+conditioning+systems.&rft.au=Tubbs%2C+R+L&rft.aulast=Tubbs&rft.aufirst=R&rft.date=2001-05-01&rft.volume=16&rft.issue=5&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ultrafine beryllium number concentration as a possible metric for chronic beryllium disease risk. AN - 70855232; 11370941 AB - Beryllium is a lightweight metal which causes a chronic granulomatous lung disease among workers who become sensitized to it. Recent research has shown a persistence of the disease despite efforts at control with mean exposures below the Occupational Safety and Health Administration (OSHA) occupational exposure limit of 2 microg/m3. Results of our current research confirm a previous finding in certain plants that particle number concentrations are higher in areas where historical estimate of risk showed a high risk of disease despite relatively lower mass concentrations. By providing side-by-side measurements of both particle number and mass, this research adds support to the proposal that particle number rather than particle mass may be more reflective of target organ dose and subsequently a more appropriate measure of exposure for chronic beryllium disease. Our evidence also shows that particle mass exposure measurements and particle number exposure measurements were not correlated. JF - Applied occupational and environmental hygiene AU - McCawley, M A AU - Kent, M S AU - Berakis, M T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 631 EP - 638 VL - 16 IS - 5 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Particle Size KW - Humans KW - Risk Assessment -- methods KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Berylliosis -- prevention & control KW - Occupational Exposure -- adverse effects KW - Beryllium -- adverse effects KW - Beryllium -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70855232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Ultrafine+beryllium+number+concentration+as+a+possible+metric+for+chronic+beryllium+disease+risk.&rft.au=McCawley%2C+M+A%3BKent%2C+M+S%3BBerakis%2C+M+T&rft.aulast=McCawley&rft.aufirst=M&rft.date=2001-05-01&rft.volume=16&rft.issue=5&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemoglobin adducts and sister chromatid exchanges in hospital workers exposed to ethylene oxide: effects of glutathione S-transferase T1 and M1 genotypes. AN - 70854851; 11352866 AB - Ethylene oxide (EtO) is a genotoxic carcinogen with widespread uses as an industrial chemical intermediate and sterilant. We examined the effects of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) genotypes on the levels of N-(2-hydroxyethyl)valine (HEV) adducts in the erythrocytes and sister chromatid exchange (SCE) in lymphocytes from a group of 58 operators of sterilizers that used EtO and nonexposed workers from nine hospitals in the United States and one hospital in Mexico City. Cumulative exposure to EtO was estimated during the 4-month period before the collection of blood samples. Results showed that EtO exposure was significantly associated with the levels of HEV adducts and SCE after adjusting for cigarette smoking and other potential confounders. A significantly higher HEV adduct level (0.17 +/- 0.03 versus 0.08 +/- 0.01, mean +/- SE; P = 0.02) but lower SCE frequency (5.31 +/- 0.39 versus 6.21 +/- 0.17; P = 0.04) was observed in subjects with homozygous deletion of the GSTT1 gene (null genotype) as compared with those with at least one copy of the gene (positive genotype). In multiple regression analysis, the GSTT1-null genotype was associated with an increase in HEV adduct level (beta = 1.62; P = 0.02) and a decrease in SCE frequency (beta = -1.25; P = 0.003) after adjusting for age, gender, race, education, cigarette smoking, and EtO exposure status. The inverse SCE-GSTT1 relationship remained unchanged when SCE was further examined in relation to HEV adducts as an indicator of the internal EtO dose. The GSTM1 genotype was not associated with the level of either HEV adduct or SCE. These data indicate that the GSTT1-null genotype is associated with increased formation of EtO-hemoglobin adducts in relation to occupational EtO exposure, suggesting that individuals with homozygous deletion of the GSTT1 gene may be more susceptible to the genotoxic effects of ETO: The unexpected finding of decreased SCEs, which is less clear, may be attributed to the nonchemical specificity of this end point and the lack of expression of the GSTT1 enzyme in lymphocytes. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Yong, L C AU - Schulte, P A AU - Wiencke, J K AU - Boeniger, M F AU - Connally, L B AU - Walker, J T AU - Whelan, E A AU - Ward, E M AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 539 EP - 550 VL - 10 IS - 5 SN - 1055-9965, 1055-9965 KW - Carcinogens KW - 0 KW - DNA Adducts KW - Disinfectants KW - Hemoglobins KW - glutathione S-transferase T1 KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Ethylene Oxide KW - JJH7GNN18P KW - Index Medicus KW - Sensitivity and Specificity KW - Probability KW - Analysis of Variance KW - Humans KW - Linear Models KW - Aged KW - Risk Assessment KW - Genotype KW - Disinfectants -- adverse effects KW - Risk Factors KW - Adult KW - Middle Aged KW - Environmental Monitoring -- methods KW - Female KW - Male KW - Carcinogens -- adverse effects KW - Hemoglobins -- drug effects KW - DNA Adducts -- genetics KW - Personnel, Hospital KW - Ethylene Oxide -- adverse effects KW - Sister Chromatid Exchange -- drug effects KW - Occupational Exposure -- adverse effects KW - Hemoglobins -- genetics KW - Glutathione Transferase -- genetics KW - Sister Chromatid Exchange -- genetics KW - Glutathione Transferase -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70854851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Hemoglobin+adducts+and+sister+chromatid+exchanges+in+hospital+workers+exposed+to+ethylene+oxide%3A+effects+of+glutathione+S-transferase+T1+and+M1+genotypes.&rft.au=Yong%2C+L+C%3BSchulte%2C+P+A%3BWiencke%2C+J+K%3BBoeniger%2C+M+F%3BConnally%2C+L+B%3BWalker%2C+J+T%3BWhelan%2C+E+A%3BWard%2C+E+M&rft.aulast=Yong&rft.aufirst=L&rft.date=2001-05-01&rft.volume=10&rft.issue=5&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. AN - 70851792; 11361228 AB - To assess whether breast implant rupture or extracapsular silicone are associated with selected symptoms of self-reported physician-diagnosed connective tissue disease (CTD). Women with silicone gel breast implants responded to a questionnaire that included questions on health status, satisfaction with implants, symptoms of CTD, and physician-diagnosed disease. These women then had magnetic resonance imaging (MRI) of their breasts to determine the status of the implants with respect to rupture and extracapsular silicone. Women with breast implant rupture diagnosed by MRI were no more likely to report a diagnosis of selected CTD than those with intact implants or those with implants of indeterminate status. Women with extracapsular silicone (silicone gel outside of the fibrous scar that forms around breast implants) were more likely to report having fibromyalgia (FM, p = 0.004) or other CTD, which included dermatomyositis, polymyositis, Hashimoto's thyroiditis, mixed CTD, pulmonary fibrosis, eosinophilic fasciitis, and polymyalgia (p = 0.008) than other women in the study. The association with FM remained statistically significant when adjusted for multiple comparisons (7 diagnoses) and implant age, implant location, or implant manufacturer (p < 0.05 in all cases), but became of borderline statistical significance when adjusted for multiple comparisons and self-perceived health status (p = 0.094) or self-perceived rupture status (p = 0.051). The association with other CTD remained statistically significant when adjusted for multiple comparisons and implant location or implant manufacturer, but became borderline or insignificant when adjusted for multiple comparisons and for implant age (p = 0.051), self-perceived health status (p = 0.434), or self-perceived rupture status (p = 0.145). Logistic regression was used to compute odds ratios of self-reported diagnoses comparing women with and without extracapsular silicone. The odds ratios were 2.8 (95% CI 1.2 to 6.3) for FM, and 2.6 (95% CI 0.8 to 8.5) for other CTD after adjustment for implant age, implant location, implant manufacturer, implant type, self-perceived health, self-perceived rupture status, and site of surgery practice. These data suggest an association between extracapsular silicone from ruptured silicone breast implants and FM. If this association persists in other studies, women with silicone gel breast implants should be informed of the potential risk of developing fibromyalgia if their breast implants rupture and the silicone gel escapes the fibrous scar capsule. JF - The Journal of rheumatology AU - Brown, S L AU - Pennello, G AU - Berg, W A AU - Soo, M S AU - Middleton, M S AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 996 EP - 1003 VL - 28 IS - 5 SN - 0315-162X, 0315-162X KW - Silicone Gels KW - 0 KW - Index Medicus KW - Prosthesis Failure KW - Patient Satisfaction KW - Raynaud Disease -- epidemiology KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Female KW - Fibromyalgia -- epidemiology KW - Silicone Gels -- adverse effects KW - Health Status KW - Breast Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70851792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Silicone+gel+breast+implant+rupture%2C+extracapsular+silicone%2C+and+health+status+in+a+population+of+women.&rft.au=Brown%2C+S+L%3BPennello%2C+G%3BBerg%2C+W+A%3BSoo%2C+M+S%3BMiddleton%2C+M+S&rft.aulast=Brown&rft.aufirst=S&rft.date=2001-05-01&rft.volume=28&rft.issue=5&rft.spage=996&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-05-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Rheumatol. 2002 Nov;29(11):2468-9; author reply 2469-70 [12696560] J Rheumatol. 2001 Dec;28(12):2760-1; author reply 2761-2 [11764233] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Growth of Salmonella during sprouting of alfalfa seeds associated with salmonellosis outbreaks. AN - 70847899; 11357873 AB - Growth of Salmonella was assessed during sprouting of naturally contaminated alfalfa seeds associated with two outbreaks of salmonellosis. Salmonella was determined daily in sprouts and sprout rinse water samples by a three-tube most probable number (MPN) procedure and a commercial enzyme immunoassay (EIA). Growth of Salmonella in the sprouts was reflected in the rinse water, and the MPNs of the two samples were generally in agreement within approximately 1 log. The results from EIA testing of sprouts and water samples were also in agreement. The pathogen was present in the seed at less than 1 MPN/g, and it increased in number to maximum population levels of 102 to 10(3) MPN/g in one seed lot and 10(2) to 10(4) MPN/ g in the other seed lot. Maximum populations of the pathogen were apparent by day 2 of sprouting. These results show the ability of the pathogen to grow to detectable levels during the sprouting process, and they provide support for the recommendation to test the sprout water for the presence of pathogens 48 h after starting seed sprouting. The effectiveness of a 10-min, 20,0000-microg/ml (ppm) calcium hypochlorite treatment of the outbreak-associated seeds was studied. For both seed lots, the hypochlorite treatment caused a reduction, but not elimination, of Salmonella contamination in the finished sprouts. These results confirm the need to test each production batch for the presence of pathogens, even after 20,000 microg/ml (ppm) hypochlorite treatment of seeds, so that contaminated product is not distributed. JF - Journal of food protection AU - Stewart, D S AU - Reineke, K F AU - Ulaszek, J M AU - Tortorello, M L AD - US Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 618 EP - 622 VL - 64 IS - 5 SN - 0362-028X, 0362-028X KW - Calcium Compounds KW - 0 KW - calcium hypochlorite KW - 11DXB629VZ KW - Index Medicus KW - Germination KW - Salmonella Food Poisoning -- prevention & control KW - Humans KW - Colony Count, Microbial KW - Disease Outbreaks KW - Water Microbiology KW - Time Factors KW - Immunoenzyme Techniques KW - Salmonella -- drug effects KW - Medicago sativa -- microbiology KW - Salmonella -- growth & development KW - Salmonella -- pathogenicity KW - Calcium Compounds -- pharmacology KW - Seeds -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70847899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Growth+of+Salmonella+during+sprouting+of+alfalfa+seeds+associated+with+salmonellosis+outbreaks.&rft.au=Stewart%2C+D+S%3BReineke%2C+K+F%3BUlaszek%2C+J+M%3BTortorello%2C+M+L&rft.aulast=Stewart&rft.aufirst=D&rft.date=2001-05-01&rft.volume=64&rft.issue=5&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure assessment of dioxins/furans consumed in dairy foods and fish. AN - 70846926; 11358181 AB - Dioxins/furans are ubiquitous environmental contaminants whose primary route of human exposure occurs via the consumption of fatty foods of animal origin. The US FDA conducted a market basket survey of dairy products and commercial fish and shellfish to obtain data on levels of 17 dioxin/furan congeners (2, 3, 7, 8-congeners) in the US. The dairy products sampled included various cheeses (American, cheddar, Swiss, cottage), ice cream, yogurt, butter, and milk. The finfish and shellfish (molluscs and crustacea) sampled are those marine species consumed in the greatest amounts and include canned tuna, shrimp, cod, blue crab, and oysters. Catfish was sampled because it is the dominant aquaculture species. Samples were collected in 1995/96 and analysis for 17 dioxin/furan congeners was performed by high-resolution gas chromatography following extraction and clean-up. Limits of detection (LOD) and quantitation (LOQ) for each congener in each food were reported. Point estimates of exposure were calculated using a 3-day (1-day diary plus 2-day recall) food consumption survey for eaters-only and for the general population (USDA/CSFII, 1989-92). Toxicity equivalency factors (TEFs) developed by the World Health Organization (1997) were used to derive overall dioxin/furan toxicity equivalents (TEQ) for each sample food. Mean estimates of TEQ exposure for each food were derived using five values for non-detects (ND = 0; ND = 1/2 LOD or LOQ, ND = LOD or LOQ) on both a total sample and eaters-only basis. Using zero and the LOD provide lower and upper bounds on the range of estimated exposure, respectively. The bounds on mean dioxin intakes (pg/person/day) calculated for consumers of specific foods were estimated as follows (using zero or LOD for non-detects): butter (0.5-11), cheese (1.6-3.2), ice cream (4-19), yogurt (0.8-28), catfish (148-150), fish (other than catfish) (0.03-9), crustacea (32-35), mollusks (16.1-16.6), and shrimp (0.09-4.5). Exposure estimates derived by the five ND-methods are strongly dependent on the LOD and LOQ and represent upper bound estimates of exposure. Uncertainty in the exposure estimates is reduced with refinements in the analytical method. JF - Food additives and contaminants AU - Jensen, E AU - Bolger, P M AD - Center for Food Safety and Applied Nutrition, US Food Drug Administration, Washington, DC 20204, USA. ejensen@cfsan.fda.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 395 EP - 403 VL - 18 IS - 5 SN - 0265-203X, 0265-203X KW - Dioxins KW - 0 KW - Furans KW - Index Medicus KW - Animals KW - Age Factors KW - Sex Factors KW - Humans KW - Aged KW - Child KW - Child, Preschool KW - Eating KW - Infant KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Catfishes -- metabolism KW - Furans -- administration & dosage KW - Dioxins -- analysis KW - Food Contamination -- analysis KW - Dioxins -- administration & dosage KW - Fishes -- metabolism KW - Dairy Products -- analysis KW - Furans -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70846926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Exposure+assessment+of+dioxins%2Ffurans+consumed+in+dairy+foods+and+fish.&rft.au=Jensen%2C+E%3BBolger%2C+P+M&rft.aulast=Jensen&rft.aufirst=E&rft.date=2001-05-01&rft.volume=18&rft.issue=5&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An improved method for the recovery of Salmonella serovars from orange juice using universal preenrichment broth. AN - 70838425; 11347996 AB - The relative effectiveness of three methods for the recovery of Salmonella serovars from orange juice was determined. One method, a modified Bacteriological Analytical Manual (BAM) procedure consisted of preenrichment in lactose broth at 35 degrees C for 24 h, selective enrichment, and selective plating. Another method, a National Centers for Disease Control and Prevention (CDC 1) procedure, consisted of direct enrichment in tetrathionate broth at 35 degrees C for 24 and 48 h, followed by selective plating. The third method (also from CDC and designated CDC 2) consisted of preenrichment in Universal Preenrichment (UP) broth at 35 degrees C for 24 h, selective enrichment, and selective plating. In 10 experiments encompassing five different Salmonella serovars and 200 test portions per broth, the CDC 1 method recovered 141 Salmonella-positive test portions, the BAM method recovered 151, and the CDC 2 method recovered 171. In 2 of the 10 experiments, with two different Salmonella serovars, the BAM recovered significantly fewer (P < 0.05) Salmonella-positive test portions than did the CDC 2 method. On the basis of the above results, the second phase of this study focused on a comparison of the effectiveness of the BAM-recommended lactose broth and the CDC 2-recommended UP broth as preenrichment media for the recovery of Salmonella serovars from pasteurized and unpasteurized orange juice. Subsequent culture treatment of the two preenrichments was identical so that the effect of other variables (e.g., different selective enrichment media, various incubation temperatures, and different selective plating agars) on the relative performance of these two preenrichment media was excluded. In one of nine experiments, with pasteurized orange juice, lactose broth recovered significantly fewer (P < 0.05) Salmonella-positive test portions than did UP broth. For the combined results of the nine pasteurized orange juice experiments (180 test portions per broth), lactose broth recovered 99 Salmonella-positive test portions, and UP broth recovered 116. In three of seven experiments, with unpasteurized orange juice, lactose broth recovered significantly fewer (P < 0.05) Salmonella-positive test portions than did UP broth. For the combined results of the seven unpasteurized orange juice experiments (140 test portions per broth), lactose broth recovered 73 Salmonella-positive test portions, and UP broth recovered 117. For both pasteurized and unpasteurized orange juice, the total number of Salmonella-positive test portions recovered with UP broth was significantly greater than the number recovered with lactose broth. These results indicate that UP broth is a more effective enrichment broth for the recovery of Salmonella from orange juice than is lactose broth. JF - Journal of food protection AU - Hammack, T S AU - Amaguaña, R M AU - Andrews, W H AD - Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA. Thomas.Hammack@cfsan.fda.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 659 EP - 663 VL - 64 IS - 5 SN - 0362-028X, 0362-028X KW - Culture Media KW - 0 KW - Index Medicus KW - Food Microbiology KW - Temperature KW - Bacteriological Techniques KW - Citrus -- microbiology KW - Beverages -- microbiology KW - Salmonella -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70838425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=An+improved+method+for+the+recovery+of+Salmonella+serovars+from+orange+juice+using+universal+preenrichment+broth.&rft.au=Hammack%2C+T+S%3BAmagua%C3%B1a%2C+R+M%3BAndrews%2C+W+H&rft.aulast=Hammack&rft.aufirst=T&rft.date=2001-05-01&rft.volume=64&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice. AN - 70837681; 11359696 AB - Fumonisin B1 (FB1) is a mycotoxin isolated from Fusarium fungi that contaminate crops worldwide. A previous study demonstrated that FB1 promoted preneoplastic foci in initiated rats and induced hepatocellular carcinomas in BD IX rats at 50 parts per million (ppm), but fundamental dose-response data were not available to assist in setting regulatory guidelines for this mycotoxin. To provide this information, female and male F344/N/Nctr BR rats and B6C3F1 Nctr BR mice were fed for two years a powdered NIH-31 diet containing the following concentrations of FB1: female rats, 0, 5, 15, 50, and 100 ppm; male rats, 0, 5, 15, 50, and 150 ppm; female mice, 0, 5, 15, 50, and 80 ppm; male mice, 0, 5, 15, 80, and 150 ppm. FB1 was not tumorigenic in female F344 rats with doses as high as 100 ppm. Including FB1 in the diets of male rats induced renal tubule adenomas and carcinomas in 0/48, 0/40, 9/48, and 15/48 rats at 0, 5, 15, 50, and 150 ppm, respectively. Including up to 150 ppm FB1 in the diet of male mice did not affect tumor incidence. Hepatocellular adenomas and carcinomas were induced by FB1 in the female mice, occurring in 5/47, 3/48, 1/48, 19/47, and 39/45 female mice that consumed diets containing 0, 5, 15, 50, and 80 ppm FB1, respectively. This study demonstrates that FB1 is a rodent carcinogen that induces renal tubule tumors in male F344 rats and hepatic tumors in female B6C3F1 mice. JF - Environmental health perspectives AU - Howard, P C AU - Eppley, R M AU - Stack, M E AU - Warbritton, A AU - Voss, K A AU - Lorentzen, R J AU - Kovach, R M AU - Bucci, T J AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. phoward@nctr.fda.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 277 EP - 282 VL - 109 Suppl 2 SN - 0091-6765, 0091-6765 KW - Carboxylic Acids KW - 0 KW - Carcinogens, Environmental KW - Fumonisins KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Animals KW - Fusarium KW - Liver -- cytology KW - Animal Feed -- adverse effects KW - Dose-Response Relationship, Drug KW - Biological Assay KW - Kidney -- drug effects KW - Mice KW - Kidney Tubules -- physiopathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Liver -- physiopathology KW - Kidney Tubules -- cytology KW - Liver -- drug effects KW - Kidney Tubules -- drug effects KW - Body Weight -- drug effects KW - Kidney -- cytology KW - Male KW - Female KW - Survival Analysis KW - Carcinogens, Environmental -- administration & dosage KW - Kidney Neoplasms -- pathology KW - Mycotoxins -- administration & dosage KW - Carboxylic Acids -- administration & dosage KW - Liver Neoplasms, Experimental -- pathology KW - Kidney Neoplasms -- chemically induced KW - Liver Neoplasms, Experimental -- chemically induced KW - Carcinogens, Environmental -- toxicity KW - Mycotoxins -- toxicity KW - Carboxylic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70837681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Fumonisin+b1+carcinogenicity+in+a+two-year+feeding+study+using+F344+rats+and+B6C3F1+mice.&rft.au=Howard%2C+P+C%3BEppley%2C+R+M%3BStack%2C+M+E%3BWarbritton%2C+A%3BVoss%2C+K+A%3BLorentzen%2C+R+J%3BKovach%2C+R+M%3BBucci%2C+T+J&rft.aulast=Howard&rft.aufirst=P&rft.date=2001-05-01&rft.volume=109+Suppl+2&rft.issue=&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-05-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Toxins. 1996;4(1):34-41 [8680752] Toxicol Pathol. 1995 Jul-Aug;23(4):458-76 [7501958] Food Chem Toxicol. 1997 Jul;35(7):647-56 [9301647] Chem Biol Interact. 2000 Oct 16;128(2):141-57 [11024453] Br J Cancer. 1975 Feb;31(2):197-206 [1164469] Food Cosmet Toxicol. 1981 Aug;19(4):447-56 [7274878] Onderstepoort J Vet Res. 1981 Jun;48(2):129-31 [7312307] Int J Cancer. 1984 Sep 15;34(3):383-7 [6480156] Cancer Res. 1986 Sep;46(9):4372-8 [3731095] J Natl Cancer Inst. 1987 Feb;78(2):321-5 [3468296] Biometrics. 1988 Jun;44(2):417-31 [3390507] S Afr Med J. 1988 Aug 6;74(3):110-4 [3399988] Appl Environ Microbiol. 1988 Jul;54(7):1806-11 [2901247] Toxicol Appl Pharmacol. 1989 Dec;101(3):414-31 [2481346] Cancer Res. 1991 Jul 1;51(13):3512-21 [1711412] Appl Environ Microbiol. 1991 Apr;57(4):1089-93 [2059033] Carcinogenesis. 1991 Jul;12(7):1247-51 [1649015] Appl Environ Microbiol. 1992 Mar;58(3):984-9 [1575501] Mycopathologia. 1992 Feb;117(1-2):23-8 [1513370] Mycopathologia. 1992 Feb;117(1-2):29-36 [1513371] J Toxicol Environ Health. 1993 Mar;38(3):309-28 [8450559] Int J Food Microbiol. 1993 Jun 1;18(4):257-70 [8347425] Nat Toxins. 1993;1(4):222-8 [8167938] Mycopathologia. 1994 Sep;127(3):183-8 [7808512] Fundam Appl Toxicol. 1995 Jan;24(1):102-10 [7713333] Pharmacol Ther. 1996;70(2):137-61 [8843466] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of Cr(VI)-induced p53 activation: the role of phosphorylation, mdm2 and ERK. AN - 70794197; 11323395 AB - The present study investigated the molecular mechanisms of p53 activation induced by Cr(VI), using human lung epithelial A549 cells. Cr(VI) increased both protein level and transactivation ability of p53 protein. The activation of p53 is at the protein level instead of the transcriptional level. The degradation of p53 was dramatically decreased upon stimulation by Cr(VI). In addition, Cr(VI) treatment decreased the interaction of p53 with mdm2 protooncoprotein, which blocks the transactivation ability of p53 and promotes the degradation of p53 protein. In response to Cr(VI) treatment, p53 protein became phosphorylated and acetylated at Ser15 and Lys382, respectively. The phosphorylation levels at either Ser20 or Ser392 did not show any significant alterations. Since previous studies report that it is Ser20 and not Ser15 phosphorylation that contributes to mdm2 dissociation from p53, the results obtained from the current investigation suggest a different mechanism: Ser15 instead of Ser20 may play a key role in the dissociation of mdm2 in response to Cr(VI). Erk, a member of mitogen-activated protein kinase, acts as the upstream kinase for the phosphorylation of the p53 Ser15 site. JF - Carcinogenesis AU - Wang, S AU - Shi, X AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 757 EP - 762 VL - 22 IS - 5 SN - 0143-3334, 0143-3334 KW - Nuclear Proteins KW - 0 KW - Proto-Oncogene Proteins KW - Tumor Suppressor Protein p53 KW - Chromium KW - 0R0008Q3JB KW - MDM2 protein, human KW - EC 2.3.2.27 KW - Proto-Oncogene Proteins c-mdm2 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Phosphorylation KW - Humans KW - Protein Processing, Post-Translational KW - Transcription, Genetic KW - Mitogen-Activated Protein Kinases -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Chromium -- pharmacology KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70794197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Mechanisms+of+Cr%28VI%29-induced+p53+activation%3A+the+role+of+phosphorylation%2C+mdm2+and+ERK.&rft.au=Wang%2C+S%3BShi%2C+X&rft.aulast=Wang&rft.aufirst=S&rft.date=2001-05-01&rft.volume=22&rft.issue=5&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Northeast Conference on Rural HIV Service Delivery (Burlington, Vermont, October 23-24, 2000). Summary Report. AN - 62257822; ED455998 AB - The Northeast Conference on Rural HIV Service Delivery was attended by 51 health and social service professionals, people with HIV, and federal and state health officials with expertise or interest in developing HIV care capacity in rural areas. Low population density, low prevalence of HIV/AIDS, rugged topography and climate, and limited health care infrastructure were identified as access barriers for rural people living with HIV. Three models presented for delivering health and support services to rural residents with HIV were urban outreach, community-based physician networks, and shared care. HIV continuing professional education programs for rural providers should be responsive to local variations in health care delivery, time effective, case-specific, and provided at little or no cost. Rural areas need primary care physicians and mid-level practitioners who are trained to recognize the signs and symptoms of HIV infection and to work with HIV specialists. Linkages with urban-based specialists need to be strengthened through telemedicine, telephone consultations, and visits by specialists to rural sites. Rural areas also need to plan for changes in HIV care that may be required by changing Medicaid policies and payment arrangements. Funding and training are needed to provide the higher levels of support required by increasing numbers of HIV-positive patients with chemical dependence, mental disorders, and hepatitis C. Resources were identified to help rural areas develop HIV service capacity. (TD) AU - McKinney, Martha M. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 50 PB - Web site: http://hab, hrsagov KW - Training Needs KW - United States (Northeast) KW - ERIC, Resources in Education (RIE) KW - Acquired Immune Deficiency Syndrome KW - Delivery Systems KW - Educational Needs KW - Rural Areas KW - Professional Continuing Education KW - Models KW - Distance Education KW - Health Needs KW - Public Health KW - Professional Training KW - Health Personnel KW - Access to Health Care KW - Community Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62257822?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Determination of isotopic uranium in food and water AN - 52172446; 2001-075170 JF - Journal of Radioanalytical and Nuclear Chemistry AU - Baratta, E J AU - Mackill, P Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 473 EP - 475 PB - Kluwer Academic Publishers and Akademiai Kiado, Dordrecht - Budapest VL - 248 IS - 2 SN - 0236-5731, 0236-5731 KW - water quality KW - concentration KW - isotopes KW - pollutants KW - pollution KW - drinking water KW - potability KW - radioactive isotopes KW - metals KW - food KW - quality control KW - uranium KW - U-238 KW - water resources KW - geochemistry KW - actinides KW - U-235 KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52172446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Radioanalytical+and+Nuclear+Chemistry&rft.atitle=Determination+of+isotopic+uranium+in+food+and+water&rft.au=Baratta%2C+E+J%3BMackill%2C+P&rft.aulast=Baratta&rft.aufirst=E&rft.date=2001-05-01&rft.volume=248&rft.issue=2&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+Radioanalytical+and+Nuclear+Chemistry&rft.issn=02365731&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fifth international conference on Methods and applications of radioanalytical chemistry N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 11 N1 - Document feature - 2 tables N1 - Last updated - 2013-09-20 N1 - CODEN - JRNCDM N1 - SubjectsTermNotLitGenreText - actinides; concentration; drinking water; food; geochemistry; isotopes; metals; pollutants; pollution; potability; quality control; radioactive isotopes; U-235; U-238; uranium; water quality; water resources ER - TY - JOUR T1 - Safety Data on Meningococcal Polysaccharide Vaccine from the Vaccine Adverse Event Reporting System AN - 18454428; 5428783 AB - Recent recommendations by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices may lead to the increased use of the meningococcal polysaccharide vaccine. The Vaccine Adverse Event Reporting System (VAERS) is useful for the detection of previously unrecognized reactions and for the monitoring of known reactions. Limitations of VAERS include underreporting and the inability to establish a causal relationship between vaccination and adverse events in most cases. From July 1990 through 31 October 1999, 110 adverse events were reported after receipt of meningococcal vaccine alone. Thirteen (12%) were serious, including 6 injection site reactions, 3 allergic reactions, 1 case of Guillain-Barre syndrome, and 3 miscellaneous events. Fever (30%), headache (17%), dizziness (15%), injection site hypersensitivity (13%), urticaria (12%), and paresthesia (10%) were among the most common events reported. Fever and injection site and allergic reactions are most likely causally linked to the vaccine. That there were few reports of serious adverse events, with >6 million doses having been distributed, and no clear signal of a previously unrecognized serious reaction is reassuring with regard to the safety of meningococcal vaccine. JF - Clinical Infectious Diseases AU - Ball, R AU - Braun, M M AU - Mootrey, G T AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA Y1 - 2001/05/01/ PY - 2001 DA - 2001 May 01 SP - 1273 EP - 1280 VL - 32 IS - 9 SN - 1058-4838, 1058-4838 KW - meningococcal disease KW - Microbiology Abstracts B: Bacteriology KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18454428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Safety+Data+on+Meningococcal+Polysaccharide+Vaccine+from+the+Vaccine+Adverse+Event+Reporting+System&rft.au=Ball%2C+R%3BBraun%2C+M+M%3BMootrey%2C+G+T&rft.aulast=Ball&rft.aufirst=R&rft.date=2001-05-01&rft.volume=32&rft.issue=9&rft.spage=1273&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Mutational analysis of the high-affinity BvgA binding site in the fha promoter of Bordetella pertussis AN - 18246164; 5308451 AB - In order to define a consensus binding sequence for the response regulator BvgA, we have undertaken a systematic analysis of contributions made by each nucleotide within the heptad half-sites that are present in an inverted orientation at the promoter for the fha operon. Using in vitro binding assays, we examined the full complement of 21 single point mutations symmetrically arranged in this heptad repeat. Both gel shift and nitrocellulose filter-binding assays provided evidence that nucleotides at positions 3 (thymidine), 4 (cytosine) and 7 (adenine) in the binding heptad contribute substantially to sequence-specific recognition by BvgA. Furthermore, a T to A conversion at position 6 reduced binding. Selected binding site mutations were introduced into a modified fha promoter and examined for their effects on BvgA activation of promoter activity in vivo. Only those substitutions most severely affecting binding in vitro affected promoter activity in vivo. The in vivo effects of substitutions that had a significant effect on binding in vitro but did not severely affect in vivo promoter activity under standard culture conditions could be detected in vivo either in combination with additional substitutions or from their effect on the sensitivity of the mutant promoters to modulation by magnesium sulphate. JF - Molecular Microbiology AU - Boucher, P E AU - Yang, M AU - Stibitz, S AD - Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA., boucher@cber.fda.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 991 EP - 999 PB - Blackwell Science Ltd VL - 40 IS - 4 SN - 0950-382X, 0950-382X KW - BvgA protein KW - fha gene KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Promoters KW - Bordetella pertussis KW - Operons KW - Mutagenesis KW - J 02726:RNA and ribosomes KW - N 14681:Mutagenesis techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18246164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Mutational+analysis+of+the+high-affinity+BvgA+binding+site+in+the+fha+promoter+of+Bordetella+pertussis&rft.au=Boucher%2C+P+E%3BYang%2C+M%3BStibitz%2C+S&rft.aulast=Boucher&rft.aufirst=P&rft.date=2001-05-01&rft.volume=40&rft.issue=4&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1046%2Fj.1365-2958.2001.02442.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bordetella pertussis; Promoters; Mutagenesis; Operons DO - http://dx.doi.org/10.1046/j.1365-2958.2001.02442.x ER - TY - JOUR T1 - Diesel Exhaust Particles Suppress Macrophage Function and Slow the Pulmonary Clearance of Listeria monocytogenes in Rats AN - 18200939; 5219206 AB - In this study, we tested the hypothesis that exposure to diesel exhaust particles (DEP) may increase susceptibility of the host to pulmonary infection. Male Sprague-Dawley rats received a single dose of DEP (5 mg/kg), carbon black (CB, 5 mg/kg), or saline intratracheally. Three days later, the rats were inoculated intratracheally with similar to 5,000 Listeria monocytogenes and sacrificed at 3, 5, and 7 days postinfection, and we determined the number of viable Listeria in the left lobe of lungs. The remaining lungs underwent bronchoalveolar lavage (BAL) and the retrieved BAL cells were identified and counted. Luminol-dependent chemiluminescence, a measure of reactive oxygen species (ROS) formation, generated by BAL cells was monitored and the levels of nitric oxide and tumor necrosis factor (TNF)- alpha produced by macrophages in culture were determined. At 7 days postinfection, we excised the lung-draining lymph nodes and phenotyped the lymphocyte subpopulations. Exposure of rats to DEP, but not to CB, decreased the clearance of Listeria from the lungs. Listeria-induced generation of luminol-dependent chemiluminescence by pulmonary phagocytes decreased by exposure to DEP but not CB. Similarly, Listeria-induced production of NO by alveolar macrophages was negated at 3, 5, and 7 days after inoculation in DEP-exposed rats. In contrast, CB exposure had no effect on Listeria-induced NO production at 3 days after infection and had a substantially smaller effect than DEP at later days. Exposure to DEP or CB resulted in enlarged lung-draining lymph nodes and increased the number and percentage of CD4 super(+) and CD8 super(+) T cells. These results showed that exposure to DEP decreased the ability of macrophages to produce antimicrobial oxidants in response to Listeria, which may play a role in the increased susceptibility of rats to pulmonary infection. This DEP-induced suppression is caused partially by chemicals adsorbed onto the carbon core of DEP, because impaired macrophage function and decreased Listeria clearance were not observed following exposure to CB. JF - Environmental Health Perspectives AU - Yang, H-M AU - Antonini, J M AU - Barger, M W AU - Butterworth, L AU - Roberts, J R AU - Ma, JKH AU - Castranova, V AU - Ma, JYC AD - Mail Stop 2015, PPRB/HELD, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 USA, hay7@cdc.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 515 EP - 521 VL - 109 IS - 5 SN - 0091-6765, 0091-6765 KW - diesel exhaust particles KW - rats KW - Animal models KW - diesel KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Macrophages KW - Listeria monocytogenes KW - Listeriosis KW - Particulate pollution KW - Tumor necrosis factor-a KW - Lymph nodes KW - Exhausts KW - Air pollution KW - Respiratory tract diseases KW - Lung KW - Nitric oxide KW - Immune response KW - Lavage KW - Chemiluminescence KW - J 02845:Ear, nose and respiratory tract KW - X 24154:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18200939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Diesel+Exhaust+Particles+Suppress+Macrophage+Function+and+Slow+the+Pulmonary+Clearance+of+Listeria+monocytogenes+in+Rats&rft.au=Yang%2C+H-M%3BAntonini%2C+J+M%3BBarger%2C+M+W%3BButterworth%2C+L%3BRoberts%2C+J+R%3BMa%2C+JKH%3BCastranova%2C+V%3BMa%2C+JYC&rft.aulast=Yang&rft.aufirst=H-M&rft.date=2001-05-01&rft.volume=109&rft.issue=5&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Listeria monocytogenes; Respiratory tract diseases; Macrophages; Listeriosis; Lung; Tumor necrosis factor-a; Chemiluminescence; Nitric oxide; Lavage; Lymph nodes; Exhausts; Air pollution; Particulate pollution; Immune response ER - TY - JOUR T1 - Metalworking Fluid Exposures in Small Machine Shops: An Overview AN - 18078475; 5160014 AB - Sampling was conducted in 79 small machine shops to assess airborne exposures to metalworking fluids (MWFs). Measured exposures were compared with data from the literature and exposure criteria currently recommended by the National Institute for Occupational Safety and Health and the Occupational Safety and Health Administration MWF Standards Advisory Committee. Sixty-two percent of 942 personal samples collected were less than the recommended exposure limit (REL) of 0.50 mg/m super(3) for total particulate. However, at least 1 sample exceeded the REL in 61 of the 79 facilities studied; 100% of the samples collected in 10 shops were greater than the REL. Similar trends were found for thoracic particulate exposures where 75% of 238 samples were below the thoracic particulate REL of 0.40 mg/m super(3). The ratio between thoracic and total particulate for 238 paired samples was 0.55 (r super(2)=0.73). Workers exposed to straight fluids had the highest exposures (GM=0.67 mg/m super(3)) when compared with workers exposed to other classes of MWFs. The highest exposures were measured for grinding and hobbing (GM=0.67 and 0.60 mg/m super(3), respectively). Measurements using personal impactors indicated that particle size distributions of MWF aerosols had an average mass median aerodynamic diameter of 5.3 mu m. Straight oils and soluble fluids tended to be associated with larger particles than were other fluid types; grinding and turning produced the largest particles, whereas hobbing resulted in the smallest. In general, exposures were similar in magnitude and particle size to those previously reported in large automotive plants. Therefore, workers in these small shops may have risks of adverse health effects similar to those demonstrated in the automotive industry. JF - American Industrial Hygiene Association Journal AU - Piacitelli, G M AU - Sieber, W K AU - O'Brien, D M AU - Hughes, R T AU - Glaser, R A AU - Catalano, J D AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 356 EP - 370 VL - 62 IS - 3 SN - 0002-8894, 0002-8894 KW - man KW - metal-working fluids KW - Health & Safety Science Abstracts; Toxicology Abstracts; Pollution Abstracts KW - Aerosols KW - Metal-working fluids KW - Air pollution KW - Standards KW - Occupational exposure KW - X 24153:Metabolism KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18078475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Metalworking+Fluid+Exposures+in+Small+Machine+Shops%3A+An+Overview&rft.au=Piacitelli%2C+G+M%3BSieber%2C+W+K%3BO%27Brien%2C+D+M%3BHughes%2C+R+T%3BGlaser%2C+R+A%3BCatalano%2C+J+D&rft.aulast=Piacitelli&rft.aufirst=G&rft.date=2001-05-01&rft.volume=62&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Standards; Aerosols; Occupational exposure; Air pollution; Metal-working fluids ER - TY - JOUR T1 - An Evaluation of Short-Term Exposures to Metalworking Fluids in Small Machine Shops AN - 18078063; 5160013 AB - In a study of 23 small machining shops using metalworking fluids (MWFs), real-time air monitoring using an aerosol photometer was performed to investigate the temporal nature of the exposure and to examine the relationship between the instrumental measurements and traditional sampling methods. Time-weighted averages were calculated from the aerosol photometer data and the results were compared to collocated thoracic and 37-mm closed face cassette samplers. The filter samples were analyzed for total mass and the solvent extractable fraction. Depending on the averaging period used, short-term MWF concentrations exceeded 2.0 mg/m super(3) in 13 to 39% of the plants studied. High short-term exposures were as likely to be found in plants with average concentrations below 0.4 mg/m super(3) (thoracic-gravimetric) as those above. Regression analyses indicated that the aerosol photometer most closely matched the data obtained from the thoracic fraction of the total mass. In general, the aerosol photometer overestimated the levels determined using the thoracic cyclone and filter, especially when measuring concentrations of water-based fluids. Use of a calibration factor of 0.7 for straight oils or 0.5 for water-based fluids may assist in the interpretation of aerosol photometer measurements if field calibration data are not readily available. Several approaches to determining the calibration factor from field data were evaluated; more complex calibration techniques improved the accuracy of the measurements. JF - American Industrial Hygiene Association Journal AU - O'Brien, D M AU - Piacitelli, G M AU - Sieber, W K AU - Hughes, R T AU - Catalano, J D AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 342 EP - 348 VL - 62 IS - 3 SN - 0002-8894, 0002-8894 KW - man KW - metal-working fluids KW - Health & Safety Science Abstracts; Toxicology Abstracts; Pollution Abstracts KW - Pollution monitoring KW - Aerosols KW - Metal-working fluids KW - Air pollution KW - Regression analysis KW - Occupational exposure KW - X 24153:Metabolism KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18078063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=An+Evaluation+of+Short-Term+Exposures+to+Metalworking+Fluids+in+Small+Machine+Shops&rft.au=O%27Brien%2C+D+M%3BPiacitelli%2C+G+M%3BSieber%2C+W+K%3BHughes%2C+R+T%3BCatalano%2C+J+D&rft.aulast=O%27Brien&rft.aufirst=D&rft.date=2001-05-01&rft.volume=62&rft.issue=3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Aerosols; Air pollution; Pollution monitoring; Regression analysis; Metal-working fluids ER - TY - JOUR T1 - Improved method for the recovery of hepatitis A virus from oysters AN - 18073657; 5117313 AB - Hepatitis A is one of the major infectious diseases epidemiologically associated with worldwide shellfish consumption. Molecular detection using polymerase chain reaction (PCR) to detect hepatitis A virus (HAV) in contaminated shellfish can be hindered by low virus recoveries during the concentration process and by natural PCR inhibitors in shellfish. This study evaluated and modified two major steps of a processing procedure for virus concentration from oysters: acid adsorption-elution and solvent extraction. With the addition of second and third elutions, the acid adsorption-elution step doubled the recovery to 46% of HAV seeded initially. Extraction with chloroform or chloroform-butanol resulted in lower HAV detection limits by reverse transcription-PCR (RT-PCR)-oligoprobing than extraction with the fluorocarbon, Freon. These results led to the following modified procedure: HAV was acid adsorbed at pH 4.8, eluted first with 0.05 M glycine, second with 0.5 M threonine, PEG-precipitated twice, chloroform-extracted twice, RNA-extracted, and RT-PCR (single round) amplified. Using the modified procedure, HAV was detected by RT-PCR in all trials with a seeding density of greater than or equal to 1 plaque forming unit (PFU)/g of oyster, and in which the equivalent detection limit was 0.33 PFU of HAV seeded per RT-PCR reaction (corresponding to 111 PCR units). The method developed is capable of detecting low levels of HAV in oysters environmentally contaminated. JF - Journal of Virological Methods AU - Mullendore, J L AU - Sobsey, MD AU - Shieh, CYS AD - US Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528 USA Y1 - 2001/05/01/ PY - 2001 DA - 2001 May 01 SP - 25 EP - 35 PB - Elsevier Science VL - 94 IS - 1-2 SN - 0166-0934, 0166-0934 KW - extracts KW - freon KW - hepatitis A virus KW - shellfish KW - ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts; Virology & AIDS Abstracts KW - Ostreidae KW - Extraction KW - Elution KW - Hepatitis A virus KW - Viruses KW - Enumeration KW - Pathogens KW - Public health KW - Chloroform KW - Viral diseases KW - Recovery KW - Extracts KW - Polymerase chain reaction KW - Shellfish KW - Disease detection KW - Chemical extraction KW - Q1 08484:Species interactions: parasites and diseases KW - Q4 27160:Methods and instruments KW - A 01114:Viruses KW - V 22022:Virus assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18073657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Improved+method+for+the+recovery+of+hepatitis+A+virus+from+oysters&rft.au=Mullendore%2C+J+L%3BSobsey%2C+MD%3BShieh%2C+CYS&rft.aulast=Mullendore&rft.aufirst=J&rft.date=2001-05-01&rft.volume=94&rft.issue=1-2&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Viral diseases; Shellfish; Disease detection; Pathogens; Chemical extraction; Public health; Chloroform; Extraction; Recovery; Elution; Extracts; Polymerase chain reaction; Enumeration; Ostreidae; Viruses; Hepatitis A virus ER - TY - JOUR T1 - Hospital Preparedness for Victims of Chemical or Biological Terrorism AN - 17883864; 5119686 AB - This study examined hospital preparedness for incidents involving chemical or biological weapons. By using a questionnaire survey of 224 hospital emergency departments in 4 northwestern states, we examined administrative plans, training, physical resources, and representative medication inventories. Responses were received from 186 emergency departments (83%). Fewer than 20% of respondent hospitals had plans for biological or chemical weapons incidents. About half (45%) had an indoor or outdoor decontamination unit with isolated ventilation, shower, and water containment systems, but only 12% had 1 or more self-contained breathing apparatuses or supplied air-line respirators. Only 6% had the minimum recommended physical resources for a hypothetical sarin incident. Of the hospitals providing quantitative answers about medication inventories, 64% reported sufficient ciprofloxacin or doxycycline for 50 hypothetical anthrax victims, and only 29% reported sufficient atropine for 50 hypothetical sarin victims (none had enough pralidoxime). Hospital emergency departments generally are not prepared in an organized fashion to treat victims of chemical or biological terrorism. The planned federal efforts to improve domestic preparedness will require substantial additional resources at the local level to be truly effective. JF - American Journal of Public Health AU - Wetter, D C AU - Daniell, W E AU - Treser, C D AD - Office of Emergency Preparedness, US Public Health Service Region II, 26 Federal Plaza, Room 3835, New York, NY 10278, USA, dwetter@hrsa.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 710 EP - 716 VL - 91 IS - 5 SN - 0090-0036, 0090-0036 KW - biological weapons KW - emergency medical services KW - terrorism KW - Health & Safety Science Abstracts KW - Chemical weapons KW - Health care KW - Emergency preparedness KW - Public health KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17883864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Hospital+Preparedness+for+Victims+of+Chemical+or+Biological+Terrorism&rft.au=Wetter%2C+D+C%3BDaniell%2C+W+E%3BTreser%2C+C+D&rft.aulast=Wetter&rft.aufirst=D&rft.date=2001-05-01&rft.volume=91&rft.issue=5&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Public health; Health care; Emergency preparedness; Chemical weapons ER - TY - JOUR T1 - Mortality at an Automotive Engine Foundry and Machining Complex AN - 17881767; 5125497 AB - Mortality was analyzed for an automotive engine foundry and machining complex, with process exposures derived from department assignments. Logistic regression models of mortality odds ratios (ORs) were calculated for 2546 deaths, and numbers of work-related deaths were estimated. Lung cancer mortality in the foundry was increased where cleaning and finishing of castings was performed (OR, 1.7; 95% CI, 1.15 to 2.4 [at mean exposure duration of exposed cases]) and in core-making after 1967 (OR, 1.5; 95% CI, 1.11 to 2.0). Black workers had excess lung cancer mortality in machining heat-treat operations (OR, 2.5, 95% CI, 1.4 to 4.3) and excess nonmalignant respiratory disease mortality in molding (OR, 2.5; 95% CI, 1.16 to 5.5) and core-making (OR, 2.7; 95% CI, 1.25 to 5.8). Stomach cancer mortality was elevated among workers with metalworking fluid exposures in precision grinding (OR, 2.4; 95% CI, 1.14 to 5.1). Heart disease mortality was increased among all workers in molding (OR, 1.6; 95% CI, 1.09 to 2.3), as was stroke mortality among workers exposed to metalworking fluids (OR, 1.8; 95% CI, 1.22 to 2.7). Malignant and nonmalignant liver disease mortality was elevated in assembly/testing and precision grinding. In this modern foundry, 11% of deaths were estimated to be work-related despite it's being largely in regulatory compliance over its 40-year existence. Machining plant exposures accounted for 3% or more of deaths there. JF - Journal of Occupational and Environmental Medicine AU - Park, R M AD - NIOSH, Education & Information Division, Risk Evaluation Branch (C-15), 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 483 EP - 493 VL - 43 IS - 5 SN - 1076-2752, 1076-2752 KW - man KW - foundries KW - stroke KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Stroke KW - Automotive industry KW - Cancer KW - Foundries KW - Regression analysis KW - Cardiovascular diseases KW - Industrial pollution KW - Occupational exposure KW - Heart diseases KW - Lung cancer KW - X 24240:Miscellaneous KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17881767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Mortality+at+an+Automotive+Engine+Foundry+and+Machining+Complex&rft.au=Park%2C+R+M&rft.aulast=Park&rft.aufirst=R&rft.date=2001-05-01&rft.volume=43&rft.issue=5&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Automotive industry; Mortality; Occupational exposure; Foundries; Lung cancer; Cardiovascular diseases; Cancer; Industrial pollution; Regression analysis; Heart diseases; Stroke ER - TY - JOUR T1 - Youth Violence: A Report of the Surgeon General (Executive Summary) AN - 1437932085 JF - American Journal of Health Education Y1 - 2001/05/01/ PY - 2001 DA - 2001 May 01 SP - 169 CY - Reston, VA PB - American Alliance for Health, Physical Education, Recreation, and Dance VL - 32 IS - 3 SN - 1932-5037 KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1437932085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Education&rft.atitle=Youth+Violence%3A+A+Report+of+the+Surgeon+General+%28Executive+Summary%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-05-01&rft.volume=32&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Education&rft.issn=19325037&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-01-10 ER - TY - JOUR T1 - Report of the Surgeon General's Conference on Children's Mental Health: A National Action Agenda (Vision and Goals) AN - 1437932066 JF - American Journal of Health Education Y1 - 2001/05/01/ PY - 2001 DA - 2001 May 01 SP - 179 CY - Reston, VA PB - American Alliance for Health, Physical Education, Recreation, and Dance VL - 32 IS - 3 SN - 1932-5037 KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1437932066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apao&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Education&rft.atitle=Report+of+the+Surgeon+General%27s+Conference+on+Children%27s+Mental+Health%3A+A+National+Action+Agenda+%28Vision+and+Goals%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-05-01&rft.volume=32&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Education&rft.issn=19325037&rft_id=info:doi/ DB - Periodicals Archive Online; Periodicals Index Online N1 - Last updated - 2014-01-10 ER - TY - JOUR T1 - Immunogenicity in mice of pneumococcal glycoconjugate vaccines using pneumococcal protein carriers AN - 17878395; 5126436 AB - Antibody response and protective immunity were evaluated in mice immunized with pneumococcal glycoconjugate vaccines using two pneumococcal protein carriers. Mice injected with type 9V polysaccharide (PS) conjugated to inactivated pneumolysin (Ply) or autolysin (Aly) produced high levels of IgG and IgM antibodies to both the PS and the protein carrier. Higher PS antibody titers to the pneumococcal PS conjugates were measured by ELISA using PS-Ply or PS-tetanus toxoid (TT) conjugate as a coating antigen compared with PS mixed with methylated human serum albumin. Type 9V PS (10 mu g) inhibited most of the 9V IgM and IgG antibody binding to the 9V-TT coated plate. In contrast, absorption with 19F PS did not inhibit 9V antibody binding. The avidity index of IgG antibodies in the 9V PS-Ply serum was 55.5 plus or minus 0.9, compared with 47.8 plus or minus 1.4 for 9V PS-Aly serum. Thus, high avidity of serum antibodies in conjugate-immunized mice can provide more effective functional activity for protection against pneumococcal infection. Mice immunized with these glycoconjugates exhibited rapid bacterial clearance from blood and provided cross-protection against challenge with heterologous serotypes of virulent pneumococci. These results reveal that conjugates using pneumococcal protein carriers can induce opsonophagocytic activity to destroy homologous and heterologous pneumococci, indicating that such conjugates can confer broader protective immunity than conjugates using non-pneumococcal proteins. JF - Vaccine AU - Lee, Chi-Jen AU - Wang, T R AU - Frasch, CE AD - Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29, Room 405, 1401 Rockville Pike, Rockville, MD 20892, USA Y1 - 2001/04/30/ PY - 2001 DA - 2001 Apr 30 SP - 3216 EP - 3225 VL - 19 IS - 23-24 SN - 0264-410X, 0264-410X KW - mice KW - Streptococcus pneumoniae KW - albumin KW - autolysin KW - carrier proteins KW - glycoconjugates KW - pneumolysin KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Antibody response KW - Toxoids KW - Tetanus KW - Autolysin KW - Albumin KW - Vaccines KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17878395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Immunogenicity+in+mice+of+pneumococcal+glycoconjugate+vaccines+using+pneumococcal+protein+carriers&rft.au=Lee%2C+Chi-Jen%3BWang%2C+T+R%3BFrasch%2C+CE&rft.aulast=Lee&rft.aufirst=Chi-Jen&rft.date=2001-04-30&rft.volume=19&rft.issue=23-24&rft.spage=3216&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Vaccines; Toxoids; Tetanus; Antibody response; Enzyme-linked immunosorbent assay; Albumin; Autolysin ER - TY - JOUR T1 - Preventing falls from roofs: a critical review AN - 18039429; 6020732 AB - Work-related falls from roofs remain a significant problem for workers in the construction industry. Knowledge about the main causative or initiating factors leading to fall incidents is desperately needed for fall prevention intervention. From biomechanical and psychophysiological perspectives the majority of occupational falls, including falls from roofs, can be regarded as loss-of-balance incidents. The primary objective of this paper is to summarize the current knowledge from multiple fields about factors that are related to the control of balance during roofing work. An extensive literature review identified a number of environmental, task-related and personal factors that degrade the control of balance and could be associated with the initiation of falls from roofs. These factors include visual exposure to elevation; unstable visual cues and inadequate visual information in the work environment; 'confined' and inclined support surfaces; unexpected changes in roof surface properties; load handling; physical exertion; fatigue; task complexity that diverts workers' attention; individual differences; work experience and training; and personal protective equipment. Current measures to reduce falls from roofs focus mainly on fall protection procedures, such as the use of covers, guardrails, safety nets, and personal fall arrest systems, or the application of warning-line systems, safety monitoring systems, and fall protection plans. In many instances, these procedures are not practical for the industry and current regulations allow the use of alternative means of fall protection, such as slide guards. Future research on preventing falls from roofs should consider the main effects and interactions of the environmental, task-related and personal factors that affect the balance control of workers. Research-supported improvements in the visual and physical characteristics of the roof work environment, the construction materials and methods, and work procedures and practices may result in improved workers' balance control as well as overall safety performance, and would ultimately reduce incidents of falling from a roof. JF - Ergonomics AU - Hsiao, H AU - Simeonov, P AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505 USA Y1 - 2001/04/20/ PY - 2001 DA - 2001 Apr 20 SP - 537 EP - 561 VL - 44 IS - 5 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - Training KW - Occupational safety KW - Protective equipment KW - Prevention KW - Reviews KW - falls KW - Construction industry KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18039429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Preventing+falls+from+roofs%3A+a+critical+review&rft.au=Hsiao%2C+H%3BSimeonov%2C+P&rft.aulast=Hsiao&rft.aufirst=H&rft.date=2001-04-20&rft.volume=44&rft.issue=5&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - falls; Prevention; Ergonomics; Reviews; Occupational safety; Construction industry; Protective equipment; Training ER - TY - GEN T1 - Births: Final Data for 1999. National Vital Statistics Reports, Volume 49, Number 1. AN - 62354726; ED452321 AB - This report presents data on U.S. births using information from the birth certificates of the 3.96 million births in 1999. Data are presented for maternal demographics (age, live-birth order, race, Hispanic origin, marital status, and educational attainment); maternal characteristics (medical risk factors, weight gain, tobacco use, and alcohol use); pregnant women's medical care utilization (prenatal care, obstetric procedures, labor and delivery complications, birth attendant, and delivery method); and infant characteristics (gestation, birthweight, Apgar score, abnormal conditions, congenital anomalies, and multiple births). Birth and fertility rates are presented by age, live-birth order, race, Hispanic origin, and marital status. Data by mother's state of residence, month and day of birth, sex ratio, and father's age are included. Trends in fertility patterns and maternal and infant characteristics are described. Birth and fertility rates changed little in 1999. Teenage birth rates fell slightly. Rates for women age 20-24 years declined slightly. Rates for women in their late 20s and 30s rose slightly. Number of births to unmarried women, birth rate, and percentage of births to unmarried women rose about 1 percent each. Improvements in prenatal care utilization continued. Percentage of low birthweight was 7.6 percent. Preterm births were 11.8 percent. (SM) AU - Ventura, Stephanie J. AU - Martin, Joyce A. AU - Curtin, Sally C. AU - Menacker, Fay AU - Hamilton, Brady E. Y1 - 2001/04/17/ PY - 2001 DA - 2001 Apr 17 SP - 109 PB - Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, 6525 Belcrest Road, Hyattsville, MD 20782-2003. KW - Maternal Health KW - ERIC, Resources in Education (RIE) KW - Birth Weight KW - Early Parenthood KW - Mothers KW - Infant Care KW - Birth Rate KW - Prenatal Care KW - Pregnancy KW - Life Style KW - Birth Order KW - Hispanic Americans KW - Health Behavior KW - Population Trends KW - Tables (Data) KW - Obstetrics KW - Adolescents KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62354726?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Interleukin-13 receptor as a unique target for anti-glioblastoma therapy. AN - 77031805; 11291041 AB - Surgery, radiotherapy and chemotherapy have minimally altered survival of glioblastoma patients. We explored a specific approach for glioblastoma therapy in which cellular interleukin-13 (IL-13) receptors were targeted by an IL-13 cytotoxin. A wide array of human glioblastoma cell lines expressing the receptor for IL-13 were effectively killed by an IL-13 cytotoxin, a chimeric protein composed of human IL-13 and a mutated form of Pseudomonas exotoxin (termed IL13-PE38QQR or IL-13 toxin). Daily (qd) intratumoral injections of IL-13 toxin (50 and 100 microg/kg/day) for 5 consecutive days into subcutaneous human U251 glioblastoma tumors (approx. 30 mm(2)) in nude mice resulted in complete regression of tumors in 4/5 and 5/5 mice, respectively. Tumor regression persisted for at least 221 days postimplantation. Three alternate day injections (qod) of IL-13 toxin (250 microg/kg/day) into other subcutaneous U87 glioblastoma tumors also produced durable complete responses (CR) in all 5 mice. Twice daily (bid) intraperitoneal injections of IL-13 toxin at 25 or 50 microg/kg/dose for 5 days (total doses = 10) regressed U251 tumors by 45% and 58% with 1/5 and 2/5 CRs, respectively, on day 54. Intraperitoneal administration of IL-13 toxin with an identical schedule at a dose of 50 microg/kg injected into mice bearing U87 xenografts reduced tumor burden by one-half on day 36. Similar doses (25 or 50 microg/kg) with a daily schedule (qd x 5) by the intravenous route also suppressed growth of U251 subcutaneous tumors by 75% and 81% with 1/6 CR in either group by day 34. All mice tolerated therapy well without any visible signs of toxicity. On the basis of these studies, we have initiated a Phase I clinical trial using IL13-PE38QQR in patients with recurrent glioblastoma. Published 2001 Wiley-Liss, Inc. JF - International journal of cancer AU - Husain, S R AU - Joshi, B H AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, 29 Lincoln Dr., Bethesda 20892, MD, USA. Y1 - 2001/04/15/ PY - 2001 DA - 2001 Apr 15 SP - 168 EP - 175 VL - 92 IS - 2 SN - 0020-7136, 0020-7136 KW - Bacterial Toxins KW - 0 KW - Exotoxins KW - IL13RA1 protein, human KW - Il13ra1 protein, mouse KW - Interleukin-13 KW - Interleukin-13 Receptor alpha1 Subunit KW - Receptors, Interleukin KW - Receptors, Interleukin-13 KW - Recombinant Fusion Proteins KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Injections, Intralesional KW - Injections, Intravenous KW - Humans KW - Cell Division -- drug effects KW - Mice KW - Mice, Nude KW - Brain Neoplasms -- drug therapy KW - Tumor Cells, Cultured KW - Kinetics KW - Xenograft Model Antitumor Assays KW - Tumor Stem Cell Assay KW - Recombinant Fusion Proteins -- therapeutic use KW - Exotoxins -- genetics KW - Exotoxins -- administration & dosage KW - Receptors, Interleukin -- metabolism KW - Interleukin-13 -- therapeutic use KW - Glioblastoma -- pathology KW - Exotoxins -- therapeutic use KW - Glioblastoma -- therapy KW - Interleukin-13 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77031805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Interleukin-13+receptor+as+a+unique+target+for+anti-glioblastoma+therapy.&rft.au=Husain%2C+S+R%3BJoshi%2C+B+H%3BPuri%2C+R+K&rft.aulast=Husain&rft.aufirst=S&rft.date=2001-04-15&rft.volume=92&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein. AN - 77028171; 11284697 AB - A new human 95 kDa high density lipoprotein (HDL)-binding protein (HBP) corresponding to a high affinity HDL-binding site with K(d) = 1.67 microg/mL and a capacity of 13.4 ng/mg was identified in human fetal hepatocytes. The HDL binding with the 95 kDa HBP plateaus at 2.5-5 microg/mL under reducing and nonreducing conditions. The association of HDL(3) with the 95 kDa HBP plateaued in 15-30 min while dissociation was complete in 30 min. HDL(3), apoA-I, and apoA-II were recognized by the 95 kDa HBP while low density lipoproteins (LDL) and tetranitromethane-modified HDL were not. The 95 kDa HBP predominantly resides on the surface of cells since trypsin treatment of HepG2 cells eliminated nearly 70% of HDL binding. All studied human cells and cell lines (HepG2, Caco-2, HeLa, fibroblasts, SKOV-3, PA-I) demonstrated the presence of the 95 kDa protein. Both RT-PCR and Western blotting for HB-2/ALCAM were negative in human fetal hepatocytes while Gp96/GRP94 was clearly differentiated from the 95 kDa HBP by two-dimensional electrophoretic mobility. Moreover, deglycosylation of HepG2 membrane preparations did not affect either HDL binding to the 95 kDa HBP or its size, while in contrast it affected the molecular weights of HB-2/ALCAM and SR-BI/CLA-1. We conclude that the 95 kDa HBP is a new HDL receptor candidate widely expressed in human cells and cell lines. JF - Biochemistry AU - Bocharov, A V AU - Vishnyakova, T G AU - Baranova, I N AU - Patterson, A P AU - Eggerman, T L AD - Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapy, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA. bucharov@cber.fda.gov Y1 - 2001/04/10/ PY - 2001 DA - 2001 Apr 10 SP - 4407 EP - 4416 VL - 40 IS - 14 SN - 0006-2960, 0006-2960 KW - Activated-Leukocyte Cell Adhesion Molecule KW - 0 KW - Antigens, CD36 KW - Antigens, Neoplasm KW - Carrier Proteins KW - DNA-Binding Proteins KW - Ligands KW - Lipoproteins, HDL KW - Lipoproteins, HDL3 KW - Membrane Proteins KW - Oxidants KW - RNA-Binding Proteins KW - Receptors, Immunologic KW - Receptors, Lipoprotein KW - Receptors, Scavenger KW - Reducing Agents KW - Scarb1 protein, mouse KW - Scavenger Receptors, Class B KW - high density lipoprotein receptors KW - high density lipoprotein-binding protein, rat KW - sarcoma glycoprotein gp96 rejection antigens KW - high density lipoprotein binding protein KW - 147605-06-9 KW - Tetranitromethane KW - K1G7CKU98F KW - Index Medicus KW - Tetranitromethane -- pharmacology KW - Electrophoresis, Polyacrylamide Gel KW - Humans KW - Caco-2 Cells KW - Glycosylation KW - Radioligand Assay KW - Molecular Weight KW - Receptors, Lipoprotein -- biosynthesis KW - Tumor Cells, Cultured KW - Receptors, Lipoprotein -- metabolism KW - Electrophoresis, Gel, Two-Dimensional KW - Antigens, Neoplasm -- metabolism KW - Antigens, CD36 -- metabolism KW - Oxidants -- pharmacology KW - HeLa Cells KW - Reverse Transcriptase Polymerase Chain Reaction KW - Protein Binding KW - Activated-Leukocyte Cell Adhesion Molecule -- metabolism KW - Reducing Agents -- metabolism KW - Cells, Cultured KW - Kinetics KW - Cell Membrane -- metabolism KW - DNA-Binding Proteins -- chemistry KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Lipoproteins, HDL -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77028171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Characterization+of+a+95+kDa+high+affinity+human+high+density+lipoprotein-binding+protein.&rft.au=Bocharov%2C+A+V%3BVishnyakova%2C+T+G%3BBaranova%2C+I+N%3BPatterson%2C+A+P%3BEggerman%2C+T+L&rft.aulast=Bocharov&rft.aufirst=A&rft.date=2001-04-10&rft.volume=40&rft.issue=14&rft.spage=4407&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposure to airborne mercury during gold mining operations near El Callao, Venezuela AN - 17848835; 4879153 AB - Objective: The National Institute for Occupational Safety and Health (NIOSH) recently conducted a cross-sectional study during gold mining operations near El Callao, Venezuela. The purpose of the study was to assess mercury exposures and mercury-related microdamage to the kidneys. The study consisted of concurrent occupational hygiene and biological monitoring, and an examination of the processing techniques employed at the different mining facilities. Mercury was used in these facilities to remove gold by forming a mercury-gold amalgam. The gold was purified either by heating the amalgam in the open with a propane torch or by using a small retort. Methods: Thirty-eight workers participated in this study. Some participants were employed by a large mining company, while others were considered "informal miners (self-employed). Mercury exposure was monitored by sampling air from the workers' breathing zones. These full-shift air samples were used to calculate time-weighted average (TWA) mercury exposure concentrations. A questionnaire was administered and a spot urine sample was collected. Each urine sample was analyzed for mercury, creatinine, and N-acetyl-ss-d-glucosaminidase (NAG). Results: The range for the 8-h TWA airborne mercury exposure concentrations was 0.1 to 6,315 g/m super(3), with a mean of 183 g /m super(3). Twenty percent of the TWA airborne mercury exposure measurements were above the NIOSH recommended exposure limit (REL) of 50 g/m super(3), and 26% exceeded the American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value (TLV) of 25 g/m super(3). The mean urine mercury concentration was 101 g/g creatinine (g/g-Cr), and the data ranged from 2.5 to 912 g /g-Cr. Forty-two percent of the study participants had urine mercury concentrations that exceeded the ACGIH biological exposure index (BEI) of 35 g/g-Cr. Urinary NAG excretion is considered a biological marker of preclinical, nonspecific microdamage to the kidney's proximal tubule cells. The mean urine NAG concentration was 3.6 International Units/g-Cr (IU/g-Cr) with a range of 0.5 to 11.5 IU/g-Cr. Three workers had urine NAG levels in excess of the reference values. Correlation analyses found statistically significant correlations between airborne mercury exposure and urine mercury level (P0.01), and between urine mercury level and urine NAG excretion (P0.01). In addition, the airborne mercury exposure data and urine mercury data were segregated by job tasks. A Wilcoxon rank sum test revealed significant correlations between tasks and mercury exposure (P0.03), and between tasks and urine mercury level (P0.02). Conclusions: The tasks with the highest mean airborne mercury exposures were "burning the mercury-gold amalgam and "gold refining/smelting. Recommendations were provided for improving the retort design to better contain mercury, for ventilation in the gold shops, and for medical surveillance and educational programs. JF - International Archives of Occupational and Environmental Health AU - Drake, P L AU - Rojas, M AU - Reh, C M AU - Mueller, CA AU - Jenkins, F M AD - National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315E. Montgomery, Spokane, WA 99207, USA, pcd8@cdc.gov Y1 - 2001/04/10/ PY - 2001 DA - 2001 Apr 10 SP - 206 EP - 212 PB - Springer-Verlag VL - 74 IS - 3 SN - 0340-0131, 0340-0131 KW - man KW - Venezuela KW - Venezuela, El Callao KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Ventilation KW - Heavy metals KW - Gold KW - Occupational exposure KW - Air pollution KW - Bioaccumulation KW - Urine KW - Mercury KW - Mining KW - X 24166:Environmental impact KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17848835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Occupational+exposure+to+airborne+mercury+during+gold+mining+operations+near+El+Callao%2C+Venezuela&rft.au=Drake%2C+P+L%3BRojas%2C+M%3BReh%2C+C+M%3BMueller%2C+CA%3BJenkins%2C+F+M&rft.aulast=Drake&rft.aufirst=P&rft.date=2001-04-10&rft.volume=74&rft.issue=3&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ventilation; Occupational exposure; Mining; Air pollution; Mercury; Gold; Urine; Bioaccumulation; Heavy metals ER - TY - JOUR T1 - Beryllium sensitization and disease among long-term and short-term workers in a beryllium ceramics plant AN - 17846177; 4879148 AB - Objective: Workers at a beryllium ceramics plant were tested for beryllium sensitization and disease in 1998 to determine whether the plant-wide prevalence of sensitization and disease had declined since the last screening in 1992; an elevated prevalence was associated with specific processes or with high exposures; exposure-response relationships differed for long-term workers hired before the last plant-wide screening and short-term workers hired since then. Methods: Current workers were asked to complete a questionnaire and to provide blood for the beryllium lymphocyte proliferation test (BeLPT). Those with an abnormal BeLPT were classified as sensitized, and were offered clinical evaluation for beryllium disease. Task- and time-specific measurements of airborne beryllium were combined with individual work histories to compute mean, cumulative, and peak beryllium exposures for each worker. Results: The 151 participants represented 90% of 167 eligible workers. Fifteen (9.9% of 151) had an abnormal BeLPT and were split between long-term workers (8/7710.4%) and short-term workers (7/749.5%). Beryllium disease was detected in 9.1% (7/77) of long-term workers but in only 1.4% (1/74) of short-term workers (P0.06), for an overall prevalence of 5.3% (8/151). These prevalences were similar to those observed in the earlier survey. The prevalence of sensitization was elevated in 1992 among machinists, and was still elevated in 1998 among long-term workers (7/4018%) but not among short-term workers (2/366%) with machining experience. The prevalence of sensitization was also elevated in both groups of workers for the processes of lapping, forming, firing, and packaging. The data suggested a positive relationship between peak beryllium exposure and sensitization for long-term workers and between mean, cumulative, and peak exposure and sensitization for short-term workers, although these findings were not statistically significant. Long-term workers with either a high peak exposure or work experience in forming were more likely to have an abnormal BeLPT (8/5116%) than the other long-term workers (0/26, P0.05). All seven sensitized short-term workers either had high mean beryllium exposure or had worked longest in forming or machining (7/5513% versus 0/19, P0.18). Conclusions: A plant-wide decline in beryllium exposures between the 1992 and 1998 surveys was not matched by a decline in the prevalence of sensitization and disease. Similar to findings from other studies, beryllium sensitization/disease was associated with specific processes and elevated exposures. The contrast in disease prevalence between long-term and short-term workers suggests that beryllium sensitization can occur after a short period of exposure, but beryllium disease usually requires a longer latency and/or period of exposure. The findings from this study motivated interventions to more aggressively protect and test workers, and new research into skin exposure as a route of sensitization and the contribution of individual susceptibility. JF - International Archives of Occupational and Environmental Health AU - Henneberger, P K AU - Cumro, D AU - Deubner, D D AU - Kent AU - McCawley, M AU - Kreiss, K AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M/S H-2800, Morgantown, WV 26505, USA, pkh0@cdc.gov Y1 - 2001/04/10/ PY - 2001 DA - 2001 Apr 10 SP - 167 EP - 176 PB - Springer-Verlag VL - 74 IS - 3 SN - 0340-0131, 0340-0131 KW - man KW - sensitization KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Ceramics KW - occupational diseases KW - Beryllium KW - Diseases KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17846177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Beryllium+sensitization+and+disease+among+long-term+and+short-term+workers+in+a+beryllium+ceramics+plant&rft.au=Henneberger%2C+P+K%3BCumro%2C+D%3BDeubner%2C+D+D%3BKent%3BMcCawley%2C+M%3BKreiss%2C+K&rft.aulast=Henneberger&rft.aufirst=P&rft.date=2001-04-10&rft.volume=74&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational diseases; Occupational exposure; Beryllium; Ceramics; Diseases ER - TY - JOUR T1 - Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite. AN - 77010972; 11150309 AB - Cell cycle checkpoint, a major genomic surveillance mechanism, is an important step in maintaining genomic stability and integrity in response to environmental stresses. Using cells derived from human bronchial epithelial cells, we demonstrate that NF-kappaB and c-Jun N-terminal kinase (JNK) reciprocally regulate arsenic trioxide (arsenite)-induced, p53-independent expression of GADD45 protein, a cell cycle checkpoint protein that arrests cells at the G(2)/M phase transition. Inhibition of NF-kappaB activation by stable expression of a kinase-mutated form of IkappaB kinase caused increased and prolonged induction of GADD45 by arsenite. In contrast, the induction of GADD45 by arsenite was transient and less potent in cells where the NF-kappaB activation pathway was normal. Analysis of the cell cycle profile by flow cytometry indicated that NF-kappaB inhibition potentiates arsenite-induced G(2)/M cell cycle arrest. Abrogation of JNK activation, on the other hand, decreased GADD45 expression induced by arsenite, suggesting a role for JNK activation in GADD45 induction. These results indicate a molecular mechanism by which NF-kappaB and JNK may differentially contribute to cell cycle regulation in response to arsenite. JF - The Journal of biological chemistry AU - Chen, F AU - Lu, Y AU - Zhang, Z AU - Vallyathan, V AU - Ding, M AU - Castranova, V AU - Shi, X AD - Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2001/04/06/ PY - 2001 DA - 2001 Apr 06 SP - 11414 EP - 11419 VL - 276 IS - 14 SN - 0021-9258, 0021-9258 KW - Arsenites KW - 0 KW - GADD45 protein KW - Intracellular Signaling Peptides and Proteins KW - NF-kappa B KW - Proteins KW - Teratogens KW - Tumor Suppressor Protein p53 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase 4 KW - EC 2.7.12.2 KW - Mitogen-Activated Protein Kinase Kinases KW - arsenite KW - N5509X556J KW - Index Medicus KW - Arsenites -- pharmacology KW - Humans KW - Teratogens -- pharmacology KW - Cell Line KW - Cell Cycle -- drug effects KW - Protein Biosynthesis KW - Signal Transduction -- drug effects KW - Tumor Suppressor Protein p53 -- metabolism KW - Mitogen-Activated Protein Kinase Kinases -- metabolism KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77010972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Opposite+effect+of+NF-kappa+B+and+c-Jun+N-terminal+kinase+on+p53-independent+GADD45+induction+by+arsenite.&rft.au=Chen%2C+F%3BLu%2C+Y%3BZhang%2C+Z%3BVallyathan%2C+V%3BDing%2C+M%3BCastranova%2C+V%3BShi%2C+X&rft.aulast=Chen&rft.aufirst=F&rft.date=2001-04-06&rft.volume=276&rft.issue=14&rft.spage=11414&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implantable middle ear hearing devices: Food and Drug Administration review process. AN - 85356145; pmid-11382584 AB - This article presents an overview of the role of the Food and Drug Administration in reviewing new devices and then explains this process in some detail as it applies to implantable middle ear hearing devices. The role of the Food and Drug Administration is to protect the patient and physician by reviewing devices for safety and effectiveness before they are made available for general use. JF - Otolaryngologic clinics of North America AU - Jaffee, I S AD - Ear, Nose, and Throat Devices Branch, United States Food and Drug Administration; and Drug Administration, Center for Devices and Radiological Health, Rockville, Maryland, USA. Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 515 EP - 517 VL - 34 IS - 2 SN - 0030-6665, 0030-6665 KW - Index Medicus KW - National Library of Medicine KW - *Device Approval KW - *Ear, Middle: surgery KW - *Hearing Aids KW - Humans KW - *Prostheses and Implants KW - United States KW - *United States Food and Drug Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85356145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngologic+clinics+of+North+America&rft.atitle=Implantable+middle+ear+hearing+devices%3A+Food+and+Drug+Administration+review+process.&rft.au=Jaffee%2C+I+S&rft.aulast=Jaffee&rft.aufirst=I&rft.date=2001-04-01&rft.volume=34&rft.issue=2&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Otolaryngologic+clinics+of+North+America&rft.issn=00306665&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Distributions and determinants of pre-emergent herbicide exposures among custom applicators. AN - 77042081; 11295146 AB - Custom applicators intensively apply herbicides to corn and soybean fields each spring. The primary objective of this study was to characterize the exposure distributions of the herbicides alachlor, atrazine, 2,4-D 2-ethylhexyl ester (2,4-D EH), and metolachlor among a group of applicators during the spring pre-emergent spray season. A secondary objective was to evaluate determinants of exposure and to estimate within- and between-worker variance components. Fifteen applicators were sampled using a systematic design that included spray and non-spray days and multiple measurements (five to seven) on each applicator. Air, patch, and handwash samples were collected on 89 applicator-days. Applicator-days were classified into three categories: target herbicide sprayed, non-target herbicide sprayed, and no herbicide sprayed. Mixed-model regression analysis was used. For all exposure metrics, adjusted mean herbicide exposures were significantly higher on days when target herbicides were sprayed as compared to non-spray days. For 2,4-D EH only, adjusted mean exposures on non-target herbicide spray days were significantly higher than on non-spray days. Wearing gloves significantly reduced adjusted mean hand exposure for all herbicides (4-20 fold) and adjusted mean thigh exposure for three herbicides (8-53 fold) on days the herbicides were sprayed; however, wearing gloves significantly increased adjusted mean atrazine hand and thigh exposures (9 and 7 fold, respectively) on days that non-atrazine herbicides were sprayed. Few of the other covariates were consistent determinants of exposure. For all exposure metrics, the within-worker variability (GSD(W) 2.1-5.6) was greater than the between-worker variability (GSD(B) 1.2-2.7). JF - The Annals of occupational hygiene AU - Hines, C J AU - Deddens, J A AU - Tucker, S P AU - Hornung, R W AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. cjh8@cdc.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 227 EP - 239 VL - 45 IS - 3 SN - 0003-4878, 0003-4878 KW - Herbicides KW - 0 KW - Index Medicus KW - Regression Analysis KW - Gloves, Protective KW - Equipment Design KW - Humans KW - Adult KW - Middle Aged KW - Likelihood Functions KW - Ohio KW - Agriculture KW - Occupational Exposure -- statistics & numerical data KW - Herbicides -- adverse effects KW - Occupational Exposure -- prevention & control KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77042081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Distributions+and+determinants+of+pre-emergent+herbicide+exposures+among+custom+applicators.&rft.au=Hines%2C+C+J%3BDeddens%2C+J+A%3BTucker%2C+S+P%3BHornung%2C+R+W&rft.aulast=Hines&rft.aufirst=C&rft.date=2001-04-01&rft.volume=45&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Early clinical trials of chemopreventive and biologic agents: Designs, populations, and endpoints. AN - 77039787; 11295631 AB - The optimal design for initial clinical trials of chemopreventive agents for cancer has not been determined. A single design is unlikely to be the model for chemoprevention of cancer, even for prevention of a single subtype of cancer, because of the heterogeneity of drugs under investigation and the variety of biologic effects being targeted. Factors that are important in designing initial clinical trials include the proposed mechanisms of drug action, the ability and types of assays available to detect that activity or pharmacodynamic effect, and the extent of prior clinical experience. In this article, we present a discussion of the factors to be considered in initial activity studies, followed by a specific example of early clinical assessment of a noncytotoxic agent (R-flurbiprofen, E-7869) as a potential chemopreventive agent for prostate cancer. JF - Urology AU - Keegan, P AU - Loughman, B E AD - Division of Clinical Trials Design and Analysis, Office of Therapeutics, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852-1445, USA. keegan@cber.fda.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 216 EP - 219 VL - 57 IS - 4 Suppl 1 KW - Anticarcinogenic Agents KW - 0 KW - Flurbiprofen KW - 5GRO578KLP KW - Index Medicus KW - Drug Interactions KW - Clinical Trials, Phase II as Topic KW - Humans KW - Clinical Trials, Phase I as Topic KW - Drug Screening Assays, Antitumor -- methods KW - Research Design KW - Male KW - Anticarcinogenic Agents -- therapeutic use KW - Flurbiprofen -- therapeutic use KW - Anticarcinogenic Agents -- pharmacology KW - Prostatic Neoplasms -- prevention & control KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77039787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Early+clinical+trials+of+chemopreventive+and+biologic+agents%3A+Designs%2C+populations%2C+and+endpoints.&rft.au=Keegan%2C+P%3BLoughman%2C+B+E&rft.aulast=Keegan&rft.aufirst=P&rft.date=2001-04-01&rft.volume=57&rft.issue=4+Suppl+1&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=1527-9995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. AN - 77036711; 11292685 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Huang, C AU - Ma, W Y AU - Ding, M AU - Li, J AU - Shi, X AU - Castranova, V AU - Vallyathan, V AU - Bode, A M AU - Dong, Z AD - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 1113 EP - 1114 VL - 15 IS - 6 SN - 0892-6638, 0892-6638 KW - Insulin KW - 0 KW - N-acetylsphingosine KW - Platelet Aggregation Inhibitors KW - Lindane KW - 59NEE7PCAB KW - 1,3,4,5,6-pentachlorocyclohexene-1-oxide KW - 93672-46-9 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Sphingomyelin Phosphodiesterase KW - EC 3.1.4.12 KW - Sphingosine KW - NGZ37HRE42 KW - Index Medicus KW - Animals KW - Lindane -- analogs & derivatives KW - Drug Interactions KW - Tumor Cells, Cultured KW - Enzyme Induction -- drug effects KW - Cells, Cultured KW - Enzyme Activation -- drug effects KW - Platelet Aggregation Inhibitors -- pharmacology KW - Mice KW - Lindane -- pharmacology KW - Epidermis -- drug effects KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Sphingomyelin Phosphodiesterase -- physiology KW - Sphingomyelin Phosphodiesterase -- metabolism KW - Sphingosine -- pharmacology KW - Insulin -- pharmacology KW - Epidermis -- enzymology KW - Sphingosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77036711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Involvement+of+sphingomyelinase+in+insulin-induced+phosphatidylinositol+3-kinase+activation.&rft.au=Huang%2C+C%3BMa%2C+W+Y%3BDing%2C+M%3BLi%2C+J%3BShi%2C+X%3BCastranova%2C+V%3BVallyathan%2C+V%3BBode%2C+A+M%3BDong%2C+Z&rft.aulast=Huang&rft.aufirst=C&rft.date=2001-04-01&rft.volume=15&rft.issue=6&rft.spage=1113&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-10 N1 - Date created - 2001-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. AN - 77001947; 11264025 AB - Silicosis, an interstitial lung disease prevalent among miners, sand blasters, and quarry workers, is manifested as a chronic inflammatory response leading to severe pulmonary fibrotic changes. Proinflammatory cytokines, such as TNFalpha and IL-1, produced in the lung by type II epithelial cells and alveolar macrophages, have been strongly implicated in the formation of these lesions. Recently, a number of single nucleotide polymorphisms (SNPs), which quantitatively affect mRNA synthesis, have been identified in the TNFalpha promoter and IL-1 gene cluster and their frequency is associated with certain chronic inflammatory diseases. To assess the role of these SNPs in silicosis, we examined their frequency in 325 ex-miners with moderate and severe silicosis and 164 miners with no lung disease. The odds ratio of disease for carriers of the minor variant, TNFalpha (-238), was markedly higher for severe silicosis (4.0) and significantly lower for moderate silicosis (0.52). Regardless of disease severity, the odds ratios of disease for carriers of the IL-1RA (+2018) or TNFalpha (-308) variants were elevated. There were no significant consistent differences in the distribution of the IL-1alpha (+4845) or IL-1beta (+3953) variants with respect to disease status. In addition, several significant gene-gene and gene-gene-environment interactions were observed. Different associations between moderate cases and controls versus severe cases and controls were also observed in a number of these multigene comparisons. These studies suggest that gene-environment interactions involving cytokine polymorphisms play a significant role in silicosis by modifying the extent of and susceptibility to disease. Copyright 2001 Academic Press. JF - Toxicology and applied pharmacology AU - Yucesoy, B AU - Vallyathan, V AU - Landsittel, D P AU - Sharp, D S AU - Weston, A AU - Burleson, G R AU - Simeonova, P AU - McKinstry, M AU - Luster, M I AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. Y1 - 2001/04/01/ PY - 2001 DA - 2001 Apr 01 SP - 75 EP - 82 VL - 172 IS - 1 SN - 0041-008X, 0041-008X KW - DNA Primers KW - 0 KW - Interleukin-1 KW - Tumor Necrosis Factor-alpha KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Lung -- chemistry KW - DNA -- analysis KW - Aged KW - Coal Mining KW - Lung -- pathology KW - Genotype KW - Smoking KW - Polymerase Chain Reaction KW - Polymorphism, Restriction Fragment Length KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Male KW - DNA Primers -- chemistry KW - Silicosis -- genetics KW - Polymorphism, Single Nucleotide KW - Silicosis -- pathology KW - Silicosis -- epidemiology KW - Interleukin-1 -- genetics KW - Genetic Predisposition to Disease KW - Tumor Necrosis Factor-alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77001947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Association+of+tumor+necrosis+factor-alpha+and+interleukin-1+gene+polymorphisms+with+silicosis.&rft.au=Yucesoy%2C+B%3BVallyathan%2C+V%3BLandsittel%2C+D+P%3BSharp%2C+D+S%3BWeston%2C+A%3BBurleson%2C+G+R%3BSimeonova%2C+P%3BMcKinstry%2C+M%3BLuster%2C+M+I&rft.aulast=Yucesoy&rft.aufirst=B&rft.date=2001-04-01&rft.volume=172&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ozone-induced mucous cell metaplasia. AN - 76974483; 11248130 AB - The article highlighted in this issue is "Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium," by James G. Wagner, Steven J. Van Dyken, Jon A. Hotchkiss, and Jack R. Harkema (pp. 338-347). JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Luster, M I AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. mluster@cdc.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 193 VL - 60 IS - 2 SN - 1096-6080, 1096-6080 KW - Air Pollutants KW - 0 KW - Oxidants, Photochemical KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Animals KW - Inhalation Exposure KW - Humans KW - Metaplasia -- pathology KW - Metaplasia -- chemically induced KW - Air Pollutants -- adverse effects KW - Oxidants, Photochemical -- adverse effects KW - Respiratory Mucosa -- drug effects KW - Respiratory Mucosa -- pathology KW - Ozone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76974483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Ozone-induced+mucous+cell+metaplasia.&rft.au=Luster%2C+M+I&rft.aulast=Luster&rft.aufirst=M&rft.date=2001-04-01&rft.volume=60&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Toxicol Sci. 2001 Apr;60(2):338-47 [11248146] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative relationship between arsenic exposure and AP-1 activity in mouse urinary bladder epithelium. AN - 76973037; 11248140 AB - Because of the potential of arsenic for causing cancer in humans, and of the fact of widespread environmental and occupational exposure, deriving acceptable human-limit values has been of major concern to industry as well as to regulatory agencies. Based upon epidemiological evidence and mechanistic studies, it has been argued that a non-linear dose-response model at low-level exposures is more appropriate for calculating risk than the more commonly employed linear-response models. In the present studies, dose-response relationships and recovery studies employing a cancer precursor marker, i.e., activating protein (AP)-1 DNA-binding activity, were examined in bladders of mice exposed to arsenic in drinking water and compared to histopathological changes and arsenic tissue levels in the same tissue. While AP-1 is a functionally pleomorphic transcription factor regulating diverse gene activities, numerous studies have indicated that activation of the MAP kinase pathway and subsequently increased AP-1 binding activities, is a precursor for arsenic-induced cancers of internal organs as well as the skin. We observed previously that within 8 weeks of exposure AP-1 activation occurs in urinary bladder tissue of mice exposed to arsenic in the drinking water. In the present studies, C57BL/6 mice were exposed to sodium arsenite at various concentrations in the drinking water for 8 consecutive weeks. Minimal but observable AP-1 activity occurred in bladder tissue at exposure levels below which histopathological changes or arsenic tissue accumulation was detected. Marked AP-1 DNA-binding activity only occurred at exposure levels of sodium arsenite above 20 microg/ml, where histopathological changes and accumulation of arsenic in the urinary bladder epithelium occurred. Although the experimental design did not allow statistical modeling of the entire dose-response curve, the general shape of the dose-response curve is not inconsistent with the previously proposed hypothesis that arsenic-induced cancer follows a non-linear dose-response model. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Simeonova, P P AU - Wang, S AU - Kashon, M L AU - Kommineni, C AU - Crecelius, E AU - Luster, M I AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown West Virginia 26505-2888, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 279 EP - 284 VL - 60 IS - 2 SN - 1096-6080, 1096-6080 KW - Carcinogens, Environmental KW - 0 KW - DNA-Binding Proteins KW - Transcription Factor AP-1 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Drinking KW - Animals KW - Dose-Response Relationship, Drug KW - DNA Damage KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Tissue Distribution KW - Female KW - Risk Assessment KW - Urinary Bladder -- pathology KW - Urinary Bladder -- metabolism KW - Arsenic -- pharmacokinetics KW - Arsenic -- toxicity KW - Transcription Factor AP-1 -- biosynthesis KW - Epithelium -- metabolism KW - Carcinogens, Environmental -- toxicity KW - Epithelium -- pathology KW - Epithelium -- drug effects KW - Carcinogens, Environmental -- pharmacokinetics KW - Urinary Bladder -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76973037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Quantitative+relationship+between+arsenic+exposure+and+AP-1+activity+in+mouse+urinary+bladder+epithelium.&rft.au=Simeonova%2C+P+P%3BWang%2C+S%3BKashon%2C+M+L%3BKommineni%2C+C%3BCrecelius%2C+E%3BLuster%2C+M+I&rft.aulast=Simeonova&rft.aufirst=P&rft.date=2001-04-01&rft.volume=60&rft.issue=2&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Redox reactions of hemoglobin and myoglobin: biological and toxicological implications. AN - 70931273; 11396484 AB - Direct cytotoxic effects associated with hemoglobin (Hb) or myoglobin (Mb) have been ascribed to redox reactions (involving either one- or two-electron steps) between the heme group and peroxides. These interactions are the basis of the pseudoperoxidase activity of these hemoproteins and can be cytotoxic when reactive species are formed at relatively high concentrations during inflammation and typically lead to cell death. Peroxides relevant to biological systems include hydrogen peroxide, lipid hydroperoxides, and peroxynitrite. Reactions between Hb/Mb and peroxides form the ferryl oxidation state of the protein, analogous to compounds I and II formed in the catalytic cycle of many peroxidase enzymes. This higher oxidation state of the protein is a potent oxidant capable of promoting oxidative damage to most classes of biological molecules. Free iron, released from Hb, also has the potential to promote oxidative damage via classical "Fenton" chemistry. It has become increasingly evident that Hb/Mb redox reactions or their by-products play a critical role in the pathophysiology of some disease states. This review briefly discusses the reactions of Hb/Mb with biological peroxides, potential cytotoxicity and the impact of these interactions on modulation of cell signaling pathways regulated by these reactive species. Also discussed in this article is the role of heme-protein chemistry in relation to the toxicity of hemoproteins. JF - Antioxidants & redox signaling AU - Alayash, A I AU - Patel, R P AU - Cashon, R E AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Alayash@cber.fda.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 313 EP - 327 VL - 3 IS - 2 SN - 1523-0864, 1523-0864 KW - Hemoglobins KW - 0 KW - Myoglobin KW - Peroxides KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Peroxides -- metabolism KW - Humans KW - Hemoglobins -- metabolism KW - Myoglobin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70931273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Redox+reactions+of+hemoglobin+and+myoglobin%3A+biological+and+toxicological+implications.&rft.au=Alayash%2C+A+I%3BPatel%2C+R+P%3BCashon%2C+R+E&rft.aulast=Alayash&rft.aufirst=A&rft.date=2001-04-01&rft.volume=3&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=15230864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Extremely small sample size in some toxicity studies: an example from the rabbit eye irritation test. AN - 70833220; 11350201 AB - The conventional sample-size equations based on either the precision of estimation or the power of testing a hypothesis may not be appropriate to determine sample size for a "diagnostic" testing problem, such as the eye irritant Draize test. When the animals' responses to chemical compounds are relatively uniform and extreme and the objective is to classify a compound as either irritant or nonirritant, the test using just two or three animals may be adequate. JF - Regulatory toxicology and pharmacology : RTP AU - Liu, P T AD - Division of Mathematics, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 187 EP - 191 VL - 33 IS - 2 SN - 0273-2300, 0273-2300 KW - Index Medicus KW - False Negative Reactions KW - Policy Making KW - Animals KW - Public Health KW - Reproducibility of Results KW - Humans KW - Bayes Theorem KW - Rabbits KW - Sample Size KW - Decision Making KW - Research Design KW - Risk Assessment KW - False Positive Reactions KW - Eye Diseases -- chemically induced KW - Toxicity Tests KW - Eye -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70833220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Extremely+small+sample+size+in+some+toxicity+studies%3A+an+example+from+the+rabbit+eye+irritation+test.&rft.au=Liu%2C+P+T&rft.aulast=Liu&rft.aufirst=P&rft.date=2001-04-01&rft.volume=33&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukemia mortality among radiation-exposed workers. AN - 70805156; 11319052 AB - The qualitative leukemogenicity of ionizing radiation was firmly established by studies of medical workers and patients exposed to high radiation levels in the mid-1900s. Quantitative relationships were evaluated through extensive studies of atomic bomb survivors and patients who received therapeutic radiation, for whom the duration of exposure was brief. Although many studies have been conducted of nuclear workers and others exposed occupationally, uncertainty remains about quantitative aspects of the leukemia-radiation exposure relation for low dose-rate, fractionated exposures. Some studies have shown dose-related increases in leukemia risks for certain nuclear workers in the U.S. and Europe, although these findings are inconsistent across populations. Despite limitations in low-dose epidemiology, well-designed studies among nuclear workers should inform some controversial aspects of the relation between ionizing radiation exposure and leukemia risk. JF - Occupational medicine (Philadelphia, Pa.) AU - Schubauer-Berigan, M K AU - Wenzl, T B AD - Health-Related-Energy Research Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. PY - 2001 SP - 271 EP - 287 VL - 16 IS - 2 SN - 0885-114X, 0885-114X KW - Index Medicus KW - United Kingdom -- epidemiology KW - Epidemiologic Methods KW - Military Personnel KW - Humans KW - United States -- epidemiology KW - USSR -- epidemiology KW - Occupational Exposure KW - Power Plants KW - Occupational Diseases -- etiology KW - Leukemia, Radiation-Induced -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70805156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Leukemia+mortality+among+radiation-exposed+workers.&rft.au=Schubauer-Berigan%2C+M+K%3BWenzl%2C+T+B&rft.aulast=Schubauer-Berigan&rft.aufirst=M&rft.date=2001-04-01&rft.volume=16&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Measurement of airborne fibers: a review. AN - 70802526; 11341557 AB - Current fiber measurement techniques arose primarily due to health concerns over asbestos exposure. Fiber toxicity appears to be primarily a function of fiber concentration, dimensions and durability in the lungs. There are two basic approaches to fiber measurement. Fibers can be collected on filters and counted or analyzed by light or electron microscopy; alternatively, fibers can be detected directly using a combination of fiber alignment and light scattering techniques. All of these measurement approaches work best when the fibers are simple rod-shaped particles. However, most fibers can exist as curved rods, complex bundles of fibrils, and agglomerates of fibers and compact particles. These non-ideal shapes contribute to measurement bias and variability. JF - Industrial health AU - Baron, P A AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 39 EP - 50 VL - 39 IS - 2 SN - 0019-8366, 0019-8366 KW - Mineral Fibers KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Asbestos -- analysis KW - Glass -- analysis KW - Optics and Photonics KW - Particle Size KW - Humans KW - Microscopy KW - Image Processing, Computer-Assisted KW - Mineral Fibers -- analysis KW - Air -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70802526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+health&rft.atitle=Measurement+of+airborne+fibers%3A+a+review.&rft.au=Baron%2C+P+A&rft.aulast=Baron&rft.aufirst=P&rft.date=2001-04-01&rft.volume=39&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Industrial+health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality among unionized construction plasterers and cement masons. AN - 70800303; 11323787 AB - Plasterers perform a variety of duties including interior and exterior plastering of drywall, cement, stucco, and stone imitation; the preparation, installation, and repair of all interior and exterior insulation systems; and the fireproofing of steel beams and columns. Some of the current potential toxic exposures among plasterers include plaster of Paris, silica, fiberglass, talc, and 1,1,1-trichloroethylene; asbestos had been used by the plasterers in the past. Cement masons, on the other hand, are involved in concrete construction of buildings, bridges, curbs and gutters, sidewalks, highways, streets and roads, floors and pavements and the finishing of same, when necessary, by sandblasting or any other method. Exposures include cement dust, silica, asphalt, and various solvents. Proportionate mortality ratios (PMRs) and proportionate cancer mortality ratios (PCMRs) were calculated for 99 causes of death among 12,873 members of the Operative Plasterers' and Cement Masons' International Association who died between 1972 and 1996 using United States age-, race-, and calender-specific death rates. Statistical significance (P value) of results was based upon the Poisson distribution. Among plasterers, statistically significant elevated mortality was observed for asbestosis, where the PMR reached 1,657 (P < 0.01) with eleven observed deaths and less than one death expected, for lung cancer (PCMR = 124, P < 0.01), and for benign neoplasms (PMR = 210, P < 0.05). Among cement masons, statistically significant elevated mortality was observed for cancer of the stomach (PCMR = 133, P < 0.01), benign neoplasms (PMR = 132, P < 0.01), and poisonings (PMR = 159, P < 0.05). Except for poisonings, which were not thought to be occupationally related, all of the statistically significant results occurred among those members who entered the union prior to 1950. However, the risk for lung cancer among plasterers was still elevated among those entering the union after 1970 as was the risk for stomach cancer among cement masons who entered the union after 1950. The present study suggests that plasterers and cement masons still have elevated risks for certain diseases, especially lung and stomach cancer. Therefore, union members currently living should be screened for asbestos-related diseases and educated about the future risks for these diseases. JF - American journal of industrial medicine AU - Stern, F AU - Lehman, E AU - Ruder, A AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA. fstern@cdc.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 373 EP - 388 VL - 39 IS - 4 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Asbestos KW - 1332-21-4 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Labor Unions KW - Construction Materials -- adverse effects KW - Aged, 80 and over KW - Humans KW - Adult KW - Asbestos -- adverse effects KW - Aged KW - United States -- epidemiology KW - Male KW - Silicon Dioxide -- adverse effects KW - Lung Neoplasms -- etiology KW - Stomach Neoplasms -- mortality KW - Air Pollutants, Occupational -- adverse effects KW - Occupational Diseases -- etiology KW - Lung Neoplasms -- mortality KW - Stomach Neoplasms -- etiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70800303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Mortality+among+unionized+construction+plasterers+and+cement+masons.&rft.au=Stern%2C+F%3BLehman%2C+E%3BRuder%2C+A&rft.aulast=Stern&rft.aufirst=F&rft.date=2001-04-01&rft.volume=39&rft.issue=4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Agreement between clinical examination and quantitative tests of neurologic function among 384 subjects. AN - 70788801; 11323785 AB - Quantitative neurological tests are often cheaper and easier than clinical examinations, and provide continuous data which may discriminate between exposed and nonexposed groups with more sensitivity than dichotomous (normal/abnormal) examination data. We compare clinical examinations and analogous quantitative tests for arm tremor, postural sway, and vibrotactile sensitivity (finger and toe), for 384 subjects. The "abnormal" clinical outcomes studied were relatively common (range, 3-36%), and did not result in impairment of daily activity for affected subjects. All the quantitative tests were reasonably good predictors of the corresponding clinical outcome. The most predictive test was for toe vibrotactile sensitivity. The probability of an abnormal clinical result for those in the worst quartile for the toe test was 0.63, compared with 0.36 for all subjects. Our results suggest that certain quantitative tests might be used in epidemiologic studies instead of a physical examination. JF - American journal of industrial medicine AU - Steenland, K AU - Dick, R AU - Fine, L AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226-1998, USA. nsteenland@cdc.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 361 EP - 368 VL - 39 IS - 4 SN - 0271-3586, 0271-3586 KW - Pesticides KW - 0 KW - Index Medicus KW - Tremor -- physiopathology KW - Sensitivity and Specificity KW - Odds Ratio KW - Humans KW - Occupational Diseases -- physiopathology KW - Predictive Value of Tests KW - Occupational Diseases -- chemically induced KW - Tremor -- chemically induced KW - Pesticides -- adverse effects KW - Multivariate Analysis KW - Tremor -- epidemiology KW - Logistic Models KW - Vibration KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Female KW - Male KW - Neuropsychological Tests -- statistics & numerical data KW - Neurologic Examination -- statistics & numerical data KW - Neurologic Examination -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70788801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Agreement+between+clinical+examination+and+quantitative+tests+of+neurologic+function+among+384+subjects.&rft.au=Steenland%2C+K%3BDick%2C+R%3BFine%2C+L&rft.aulast=Steenland&rft.aufirst=K&rft.date=2001-04-01&rft.volume=39&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ergonomics evaluation of zinc pot skimming. AN - 70781327; 11318382 JF - Applied occupational and environmental hygiene AU - Habes, D J AD - Hazard Evaluation and Technical Assistance Branch of NIOSH, Cincinnati, OH 45226, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 419 EP - 425 VL - 16 IS - 4 SN - 1047-322X, 1047-322X KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - United States KW - Human Engineering KW - Humans KW - Task Performance and Analysis KW - Posture -- physiology KW - Lifting -- adverse effects KW - National Institute for Occupational Safety and Health (U.S.) KW - Models, Theoretical KW - Occupational Diseases -- prevention & control KW - Carpal Tunnel Syndrome -- prevention & control KW - Job Description -- standards KW - Metallurgy KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70781327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Ergonomics+evaluation+of+zinc+pot+skimming.&rft.au=Habes%2C+D+J&rft.aulast=Habes&rft.aufirst=D&rft.date=2001-04-01&rft.volume=16&rft.issue=4&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-17 N1 - Date created - 2001-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - OxyContin: Prescription Drug Abuse. CSAT Advisory. AN - 62182437; ED473614 AB - Recently, the media have issued numerous reports about the apparent increase in OxyContin abuse and addiction. OxyContin has been heralded as a miracle drug that allows patients with chronic pain to resume a normal life. It has also been called pharmaceutical heroin and is thought to have been responsible for a number of deaths and robberies in areas where its abuse has been reported. The Center for Substance Abuse Treatment (CSAT) is interested in helping professionals on the front line of substance abuse treatment by providing them with the facts about OxyContin, its use and abuse, and how to treat individuals who present at treatment facilities with OxyContin concerns. This first issue of the CSAT Advisory answers frequently asked questions about OxyContin; provides general information about semisynthetic opioids and their addiction potential; summarizes evidence-based protocols for treatment; and provides referral sources for further information. (GCP) Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 10 KW - ERIC, Resources in Education (RIE) KW - Counselors KW - Practitioners KW - Drug Addiction KW - Drug Rehabilitation KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62182437?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Lung Cancer among Industrial Sand Workers Exposed to Crystalline Silica AN - 18489105; 5447361 AB - In 1997, the International Agency for Research on Cancer determined that crystalline silica was a human carcinogen but noted inconsistencies in the epidemiology. There are few exposure-response analyses. The authors examined lung cancer mortality among 4,626 industrial sand workers, estimating exposure via a job-exposure matrix based on 4,269 industrial hygiene samples collected in 1974-1995. The average length of employment was 9 years, and estimated average exposure was 0.05 mg/m super(3) (the National Institute of Occupational Safety and Health Recommended Exposure Limit). Results confirmed excess mortality from silicosis/pneumoconioses (standardized mortality ratio = 18.2, 95% confidence interval: 10.6, 29.1; 17 deaths). The lung cancer standardized mortality ratio was 1.60 (95% confidence interval: 1.31, 1.93; 109 deaths). Limited data suggested that smoking might account for 10-20% of the lung cancer excess. Exposure-response analyses by quartile of cumulative exposure (15-year lag) yielded standardized rate ratios of 1.00, 0.78, 1.51, and 1.57 (p for trend = 0.07). Nested case-control analyses after exclusion of short-term workers, who had high overall morality, yielded odds ratios by quartile of cumulative exposure (15-year lag) of 1.00, 1.35, 1.63, and 2.00 (p for trend = 0.08) and odds ratios by quartile of average exposure of 1.00, 0.92, 1.44, and 2.26 (p = 0.005). These data lend support to the labeling by the International Agency for Research on Cancer of silica as a human carcinogen. There are approximately 2 million US workers exposed to silica; 100,000 are exposed to more than 0.1 mg/m super(3). JF - American Journal of Epidemiology AU - Steenland, K AU - Sanderson, W AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2001/04/01/ PY - 2001 DA - 2001 Apr 01 SP - 695 EP - 703 VL - 153 IS - 7 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18489105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Lung+Cancer+among+Industrial+Sand+Workers+Exposed+to+Crystalline+Silica&rft.au=Steenland%2C+K%3BSanderson%2C+W&rft.aulast=Steenland&rft.aufirst=K&rft.date=2001-04-01&rft.volume=153&rft.issue=7&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Screening for chlamydial infection: Recommendations and rationale AN - 18465158; 5426814 AB - The U.S. Preventive Services Task Force (USPSTF) strongly recommends that clinicians routinely screen all sexually active women aged 25 years and younger, and other asymptomatic women at increased risk for infection, for chlamydial infection (see Clinical Considerations for discussion of risk factors). A recommendation. JF - American Journal of Preventive Medicine AU - Berg, A O AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Center for Practice and Technology Assessment, 6010 Executive Boulevard, Suite 300,20912, Rockville, MD, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 90 EP - 94 VL - 20 IS - 3 SN - 0749-3797, 0749-3797 KW - Microbiology Abstracts B: Bacteriology KW - J 02847:Genitourinary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18465158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Screening+for+chlamydial+infection%3A+Recommendations+and+rationale&rft.au=Berg%2C+A+O&rft.aulast=Berg&rft.aufirst=A&rft.date=2001-04-01&rft.volume=20&rft.issue=3&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Screening for bacterial vaginosis in pregnancy: Recommendations and rationale AN - 18462777; 5426812 AB - The U.S. Preventive Services Task Force (USPSTF) concludes that the evidence is insufficient to recommend for or against routinely screening high-risk pregnant women for bacterial vaginosis (BV). (See Clinical Considerations for discussion of populations at high risk.) I recommendation. JF - American Journal of Preventive Medicine AU - Berg, A O AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Center for Practice and Technology Assessment, 6010 Executive Boulevard, Suite 300, 20912, Rockville, MD, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 59 EP - 61 VL - 20 IS - 3 SN - 0749-3797, 0749-3797 KW - Bacterial vaginosis KW - man KW - Microbiology Abstracts B: Bacteriology KW - J 02847:Genitourinary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18462777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Screening+for+bacterial+vaginosis+in+pregnancy%3A+Recommendations+and+rationale&rft.au=Berg%2C+A+O&rft.aulast=Berg&rft.aufirst=A&rft.date=2001-04-01&rft.volume=20&rft.issue=3&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Production of Alternariol and Alternariol Methyl Ether by Alternaria alternata Grown on Fruits at Various Temperatures AN - 18443784; 5420804 AB - Two toxigenic strains of the fungus Alternaria alternata (ATCC 56836 and ATCC 66868) were grown on surface-disinfected, fresh, ripe fruits and tested for the production of alternariol (AOH) and alternariol methyl ether (AME). Examined fruits included strawberries; red and green seedless grapes; concord grapes; red delicious, golden delicious, and gala apples; and blueberries. After inoculation, fruits were incubated at 4, 10 degree C, or room temperature (approximately 21 degree C) for up to 3 weeks. At weekly intervals, duplicate samples were analyzed for AOH and AME by using liquid chromatography. Results indicated that A. alternata and its metabolites were not a major problem in strawberries due to the presence of fast-growing molds like Rhizopus and Botrytis that outgrew and possibly inhibited Alternaria. Both Alternaria strains showed limited growth on apples, although fast-growing molds were not present after surface disinfection; AOH and AME were produced only by the ATCC 56836 strain on the golden delicious and gala varieties, (ranging from <0.1 to 5 mu g/g and <0.1 to 14 mu g/g for AOH and AME, respectively). Restricted growth of both strains without toxin production occurred in blueberries, whereas moderate growth and AOH (<0.1 to 3,336 mu g/g) and AME (<0.1 to 1,716 mu g/g) production took place in grapes. JF - Journal of Food Protection AU - Tournas, V H AU - Stack, ME AD - Division of Natural Products, Food and Drug Administration, 200 C Street S.W., Washington, D.C. 20204, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 528 EP - 532 VL - 64 IS - 4 SN - 0362-028X, 0362-028X KW - alternariol KW - alternariol methyl ether KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01014:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18443784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Production+of+Alternariol+and+Alternariol+Methyl+Ether+by+Alternaria+alternata+Grown+on+Fruits+at+Various+Temperatures&rft.au=Tournas%2C+V+H%3BStack%2C+ME&rft.aulast=Tournas&rft.aufirst=V&rft.date=2001-04-01&rft.volume=64&rft.issue=4&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Hot Water Immersion To Eliminate Escherichia coli O157:H7 on the Surface of Whole Apples: Thermal Effects and Efficacy AN - 18443751; 5420791 AB - The effect of hot water immersion on both the reduction of Escherichia coli O157:H7 on the apple surface and internal temperatures of the apple was assessed in this study. Microbial reductions were measured experimentally, whereas internal temperatures were calculated through a mathematical analysis of experimental heat transfer data obtained from the apples. A method was developed to provide a purely surface-based inoculation of E. coli O157:H7. Rinsing produced no reduction, and treatments at 80 and 95 degree C produced reductions of more than 5 logs in 15 s or less. The heat transfer analysis based on experimental data was used to calculate surface heat transfer coefficients and predict temperatures throughout the apple. The analysis indicated a low heat transfer rate. Although it reduces thermal degradation, a low heat transfer rate precludes thermal-based reduction of any internalized microorganisms. JF - Journal of Food Protection AU - Fleischman, G J AU - Keller, SE AU - Bator, C AU - Merker, R AD - U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Avenue, Summit-Argo, Illinois 60501, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 451 EP - 455 VL - 64 IS - 4 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01019:Sterilization, preservation & packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18443751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Hot+Water+Immersion+To+Eliminate+Escherichia+coli+O157%3AH7+on+the+Surface+of+Whole+Apples%3A+Thermal+Effects+and+Efficacy&rft.au=Fleischman%2C+G+J%3BKeller%2C+SE%3BBator%2C+C%3BMerker%2C+R&rft.aulast=Fleischman&rft.aufirst=G&rft.date=2001-04-01&rft.volume=64&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Medical Insurance Claims and Surveillance for Occupational Disease: Analysis of Respiratory, Cardiac, and Cancer Outcomes in Auto Industry Tool Grinding Operations AN - 17882404; 5120578 AB - To evaluate medical insurance claims for chronic disease investigation, claims from eight automotive machining plants (1984 to 1993) were linked with work histories (1967 to 1993), and associations with respiratory, cardiac, and cancer conditions were investigated, in a case-control design analyzed with logistic regression. The primary focus was tool grinding, but other important processes examined were metal-working, welding, forging, heat treat, engine testing, and diverse-skilled trades work. Considerable variability in claim-derived incidence rates across plants was not explained by age or known exposure differences. Asthma incidence increased in tool grinding (at mean cumulative duration: odds ratio [OR], 3.0; 95% confidence interval [CI], 0.90 to 10.0), as did non-ischemic heart disease (cardiomyopathy, cor pulmonale, rheumatic heart disease, or hypertension; OR, 3.1; 95% CI, 1.26 to 7.6). These trends appeared in models with deficits (OR < 1.0) for those ever exposed to tool grinding because of exposure-response miss-specification, demographic confounding, or removal of high-risk workers from the exposed group. The apparent cancer rates identified from claims greatly exceeded the expected rates from a cancer registry, suggesting that diagnostic, "rule-out," and surveillance functions were contributing. This study supports the epidemiologic use of medical insurance records in surveillance and, possibly, etiologic investigation and identifies issues requiring special attention or resolution. JF - Journal of Occupational and Environmental Medicine AU - Park, R M AD - Risk Evaluation Branch, Education and Information Division, NIOSH C-15, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 335 EP - 346 VL - 43 IS - 4 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Cardiovascular system KW - Automotive industry KW - Insurance KW - Cancer KW - occupational diseases KW - Economics KW - Respiratory tract KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17882404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Medical+Insurance+Claims+and+Surveillance+for+Occupational+Disease%3A+Analysis+of+Respiratory%2C+Cardiac%2C+and+Cancer+Outcomes+in+Auto+Industry+Tool+Grinding+Operations&rft.au=Park%2C+R+M&rft.aulast=Park&rft.aufirst=R&rft.date=2001-04-01&rft.volume=43&rft.issue=4&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - occupational diseases; Cancer; Cardiovascular system; Respiratory tract; Economics; Insurance; Automotive industry ER - TY - JOUR T1 - Degradation of Phenanthrene and Anthracene by Cell Suspensions of Mycobacterium sp. Strain PYR-1 AN - 17841074; 4869231 AB - Cultures of Mycobacterium sp. strain PYR-1 were dosed with anthracene or phenanthrene and after 14 days of incubation had degraded 92 and 90% of the added anthracene and phenanthrene, respectively. The metabolites were extracted and identified by UV- visible light absorption, high-pressure liquid chromatography retention times, mass spectrometry, H and super(13)C nuclear magnetic resonance spectrometry, and comparison to authentic compounds and literature data. Neutral-pH ethyl acetate extracts from anthracene-incubated cells showed four metabolites, identified as cis-1, 2-dihydroxy-1, 2-dihydroanthracene, 6, 7-benzocoumarin, 1-methoxy-2-hydroxyanthracene, and 9, 10-anthraquinone. A novel anthracene ring fission product was isolated from acidified culture media and was identified as 3-(2-carboxyvinyl)naphthalene-2-carboxylic acid. 6, 7- Benzocoumarin was also found in that extract. When Mycobacterium sp. strain PYR-1 was grown in the presence of phenanthrene, three neutral metabolites were identified as cis- and trans-9, 10-dihydroxy-9, 10-dihydrophenanthrene and cis-3, 4-dihydroxy-3, 4-dihydrophenanthrene. Phenanthrene ring fission products, isolated from acid extracts, were identified as 2, 2'-diphenic acid, 1-hydroxynaphthoic acid, and phthalic acid. The data point to the existence, next to already known routes for both gram-negative and gram-positive bacteria, of alternative pathways that might be due to the presence of different dioxygenases or to a relaxed specificity of the same dioxygenase for initial attack on polycyclic aromatic hydrocarbons. JF - Applied and Environmental Microbiology AU - Moody, J D AU - Freeman, J P AU - Doerge AU - Cerniglia, CE AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, CCerniglia@nctr.fda.gov Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 1476 EP - 1483 VL - 67 IS - 4 SN - 0099-2240, 0099-2240 KW - anthracene KW - phenanthrene KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Cell suspensions KW - Anthracene KW - Polycyclic aromatic hydrocarbons KW - Biodegradation KW - Mass spectroscopy KW - Phenanthrene KW - A 01016:Microbial degradation KW - W2 32510:Waste treatment, environment, pollution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17841074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Degradation+of+Phenanthrene+and+Anthracene+by+Cell+Suspensions+of+Mycobacterium+sp.+Strain+PYR-1&rft.au=Moody%2C+J+D%3BFreeman%2C+J+P%3BDoerge%3BCerniglia%2C+CE&rft.aulast=Moody&rft.aufirst=J&rft.date=2001-04-01&rft.volume=67&rft.issue=4&rft.spage=1476&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.67.4.1476-1483.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell suspensions; Biodegradation; Mass spectroscopy; High-performance liquid chromatography; Polycyclic aromatic hydrocarbons; Phenanthrene; Anthracene DO - http://dx.doi.org/10.1128/AEM.67.4.1476-1483.2001 ER - TY - JOUR T1 - Identification and Characterization of Integron-Mediated Antibiotic Resistance among Shiga Toxin-Producing Escherichia coli Isolates AN - 17839438; 4869227 AB - A total of 50 isolates of Shiga toxin-producing Escherichia coli (STEC), including 29 O157:H7 and 21 non-O157 STEC strains, were analyzed for antimicrobial susceptibilities and the presence of class 1 integrons. Seventy-eight (n = 39) percent of the isolates exhibited resistance to two or more antimicrobial classes. Multiple resistance to streptomycin, sulfamethoxazole, and tetracycline was most often observed. Class 1 integrons were identified among nine STEC isolates, including serotypes O157:H7, O111:H11, O111:H8, O111:NM, O103:H2, O45:H2, O26:H11, and O5:NM. The majority of the amplified integron fragments were 1 kb in size with the exception of one E. coli O111:H8 isolate which possessed a 2-kb amplicon. DNA sequence analysis revealed that the integrons identified within the O111:H11, O111:NM, O45:H2, and O26:H11 isolates contained the aadA gene encoding resistance to streptomycin and spectinomycin. Integrons identified among the O157:H7 and O103:H2 isolates also possessed a similar aadA gene. However, DNA sequencing revealed only 86 and 88% homology, respectively. The 2-kb integron of the E. coli O111:H8 isolate contained three genes, dfrXII, aadA2, and a gene of unknown function, orfF, which were 86, 100, and 100% homologous, respectively, to previously reported gene cassettes identified in integrons found in Citrobacter freundii and Klebsiella pneumoniae. Furthermore, integrons identified among the O157:H7 and O111:NM strains were transferable via conjugation to another strain of E. coli O157:H7 and to several strains of Hafnia alvei. To our knowledge, this is the first report of integrons and antibiotic resistance gene cassettes in STEC, in particular E. coli O157:H7. JF - Applied and Environmental Microbiology AU - Zhao, S AU - White, D G AU - Ge, B AU - Ayers, S AU - Friedman, S AU - English, L AU - Wagner, D AU - Gaines, S AU - Meng, J AD - Office of Research, U.S. FDA/CVM, 8401 Muirkirk Rd., Laurel, MD 20708, szhao@cvm.fda.gov Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 1558 EP - 1564 VL - 67 IS - 4 SN - 0099-2240, 0099-2240 KW - Shiga toxin KW - integrons KW - streptomycin KW - sulfamethoxazole KW - tetracyclines KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Sulfamethoxazole KW - Citrobacter freundii KW - Streptomycin KW - Tetracyclines KW - Toxins KW - Escherichia coli KW - Antibiotic resistance KW - Klebsiella pneumoniae KW - A 01064:Microbial resistance KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17839438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Identification+and+Characterization+of+Integron-Mediated+Antibiotic+Resistance+among+Shiga+Toxin-Producing+Escherichia+coli+Isolates&rft.au=Zhao%2C+S%3BWhite%2C+D+G%3BGe%2C+B%3BAyers%2C+S%3BFriedman%2C+S%3BEnglish%2C+L%3BWagner%2C+D%3BGaines%2C+S%3BMeng%2C+J&rft.aulast=Zhao&rft.aufirst=S&rft.date=2001-04-01&rft.volume=67&rft.issue=4&rft.spage=1558&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.67.4.1558-1564.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Citrobacter freundii; Klebsiella pneumoniae; Antibiotic resistance; Toxins; Tetracyclines; Sulfamethoxazole; Streptomycin; Shiga toxin DO - http://dx.doi.org/10.1128/AEM.67.4.1558-1564.2001 ER - TY - RPRT T1 - An analysis of serious injuries to dozer operators in the US mining injury AN - 17441540; 6588997 AB - This report describes serious injuries occurring to bulldozer operators working at U.S. coal, metal, and nonmetal mines. The period covered is 1988-97. The data were collected by the Mine Safety and Health Administration (MSHA). A total of 873 injury records are examined. These injuries resulted in 18 fatalities and 31,866 lost workdays. All of these injuries occurred to dozer operators while they were doing common production tasks. An injury classification system was developed to code the narrative information that describes the circumstances surrounding the injuries. Injury records are categorized by activity (task being done), incident result (what apparently happened to the dozer), and operator impact (how the operator was injured). Where information is available, contributing factors are identified. This classification system supplemented the standard injury/illness data classification system compiled by MSHA. The results of the study indicate that, from 1993 to 1997, the number of serious injuries to dozer operators declined by 30%. The reduction in serious injuries was accompanied by a decrease in days lost due to injury. Although the number of reported injuries has decreased, dozer operators being jolted and jarred accounts for the largest percentage (70% of the incidents) and severity (75% of the workdays lost) of serious injuries while operating the equipment. Vertical jars (while backing up the dozer) resulting in injury to the operator accounted for a sizable percentage of jolting and jarring injuries. Further reductions in injury risk will require more widespread use of seatbelts, field and laboratory research interventions to better assess the effect of alternative engineering (e.g., seat and seat suspension) designs to dampen or isolate the effects of shock and vibration, and continued focus on hazard awareness, recognition, and response. JF - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA. [np]. Apr 2001. AU - Wiehagen, William J AU - Mayton, Alan G AU - Jaspal, Jasinder S AU - Turin, Fred C Y1 - 2001/04// PY - 2001 DA - Apr 2001 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Risk Abstracts; Health & Safety Science Abstracts KW - Metals KW - Mortality KW - USA KW - Safety regulations KW - Injuries KW - Vibration KW - Occupational safety KW - Coal KW - Mining KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17441540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Wiehagen%2C+William+J%3BMayton%2C+Alan+G%3BJaspal%2C+Jasinder+S%3BTurin%2C+Fred+C&rft.aulast=Wiehagen&rft.aufirst=William&rft.date=2001-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=An+analysis+of+serious+injuries+to+dozer+operators+in+the+US+mining+injury&rft.title=An+analysis+of+serious+injuries+to+dozer+operators+in+the+US+mining+injury&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Role of inflammation in chemical-induced hepatotoxicity. AN - 70798602; 11323190 AB - The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators that can effect liver damage or repair. This review will summarize our current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride, an industrial chemical, and acetaminophen, a widely used analgesic. JF - Toxicology letters AU - Luster, M I AU - Simeonova, P P AU - Gallucci, R M AU - Bruccoleri, A AU - Blazka, M E AU - Yucesoy, B AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505, USA. mluster@cdc.gov Y1 - 2001/03/31/ PY - 2001 DA - 2001 Mar 31 SP - 317 EP - 321 VL - 120 IS - 1-3 SN - 0378-4274, 0378-4274 KW - Proliferating Cell Nuclear Antigen KW - 0 KW - Receptors, Tumor Necrosis Factor KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Humans KW - Receptors, Tumor Necrosis Factor -- physiology KW - Tumor Necrosis Factor-alpha -- physiology KW - Proliferating Cell Nuclear Antigen -- analysis KW - Mice KW - Inflammation -- physiopathology KW - Liver -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70798602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Role+of+inflammation+in+chemical-induced+hepatotoxicity.&rft.au=Luster%2C+M+I%3BSimeonova%2C+P+P%3BGallucci%2C+R+M%3BBruccoleri%2C+A%3BBlazka%2C+M+E%3BYucesoy%2C+B&rft.aulast=Luster&rft.aufirst=M&rft.date=2001-03-31&rft.volume=120&rft.issue=1-3&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-17 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of Activator Protein-1 through Reactive Oxygen Species by Crystalline Silica in JB6 Cells AN - 17816876; 4857472 AB - We reported previously that freshly fractured silica (FFSi) induces activator protein-1 (AP-1) activation through extracellular signal-regulated protein kinases (ERKs) and p38 kinase pathways. In the present study, the biologic activities of FFSi and aged silica (ASi) were compared by measuring their effects on the AP-1 activation and phosphorylation of ERKs and p38 kinase. The roles of reactive oxygen species (ROS) in this silica-induced AP-1 activation were also investigated. We found that FFSi-induced AP-1 activation was four times higher than that of ASi in JB6 cells. FFSi also caused greater phosphorylation of ERKs and p38 kinase than ASi. FFSi generated more ROS than ASi when incubated with the cells as measured by electron spin resonance (ESR). Studies using ROS-sensitive dyes and oxygen consumption support the conclusion that ROS are generated by silica-treated cells. N-Acetylcysteine (an antioxidant) and polyvinyl pyridine-N-oxide (an agent that binds to Si-OH groups on silica surfaces) decreased AP-1 activation and phosphorylation of ERKs and p38 kinase. Catalase inhibited phosphorylation of ERKs and p38 kinase, as well as AP-1 activation induced by FFSi, suggesting the involvement of H sub(2)O sub(2) in the mechanism of silica-induced AP-1 activation. Sodium formate (an super(.)OH scavenger) had no influence on silica-induced MAPKs or AP-1 activation. Superoxide dismutase enhanced both AP-1 and MAPKs activation, indicating that H sub(2)O sub(2), but not O sub(2), may play a critical role in silica-induced AP-1 activation. These studies indicate that freshly ground silica is more biologically active than aged silica and that ROS, in particular H sub(2)O sub(2), play a significant role in silica-induced AP-1 activation. JF - Journal of Biological Chemistry AU - Ding, M AU - Shi, X AU - Lu, Y AU - Huang, C AU - Leonard, S AU - Roberts, J AU - Antonini, J AU - Castranova, V AU - Vallyathan, V AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, vav1@cdc.gov Y1 - 2001/03/23/ PY - 2001 DA - 2001 Mar 23 SP - 9108 EP - 9114 VL - 276 IS - 12 SN - 0021-9258, 0021-9258 KW - JB6 cells KW - silica KW - activator protein-1 KW - Toxicology Abstracts KW - Oxygen KW - Free radicals KW - Silicon dioxide KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17816876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Induction+of+Activator+Protein-1+through+Reactive+Oxygen+Species+by+Crystalline+Silica+in+JB6+Cells&rft.au=Ding%2C+M%3BShi%2C+X%3BLu%2C+Y%3BHuang%2C+C%3BLeonard%2C+S%3BRoberts%2C+J%3BAntonini%2C+J%3BCastranova%2C+V%3BVallyathan%2C+V&rft.aulast=Ding&rft.aufirst=M&rft.date=2001-03-23&rft.volume=276&rft.issue=12&rft.spage=9108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Silicon dioxide; Oxygen; Free radicals ER - TY - JOUR T1 - Behavioral Responses of Rats Exposed to Long-Term Dietary Vinclozolin AN - 18409063; 5395500 AB - Vinclozolin is a fungicide used on food crops with human exposure estimated at similar to 2 mu g/kg/day from ingestion; occupational exposure, however, may be greater. The metabolites of vinclozolin have been reported to act as antiandrogens and have adverse effects on reproductive physiology and behavior in animals. Here, pregnant rats were fed soy-free diets containing 0, 10, 150, or 750 ppm of vinclozolin (approximately 0, 0.8, 12, and 60 mg/kg/day for an adult) beginning on gestational day 7, and offspring were continued on these diets through sacrifice at postnatal day 77. Male and female offspring were assessed for changes in several nonreproductive sexually dimorphic behaviors: open field and running wheel locomotor activity, play behavior, and consumption of saccharin- and sodium chloride-flavored solutions. There was a significant interaction of sex with vinclozolin exposure on running wheel activity, which indicated that females in the high-dose exposure group were hypoactive compared to same-sex controls. There was a significant overall effect of vinclozolin exposure on fluid consumption, and high-dose animals showed increased intake of the saccharin solution and decreased intake of plain water while saccharin was available. Effects were more pronounced in females, which drank 40.8% more saccharin than control females, whereas males drank 6.2% more than control males. There were no effects of vinclozolin treatment on play behavior or sodium solution intake. Gestational duration, total and live pups per litter, litter sex ratios, and birth weight were also not significantly affected, nor were body weight and food intake for dams and offspring. These results indicate that long-term dietary exposure to vinclozolin does not have severe toxicological consequences on the nonreproductive behaviors measured here. However, exposure may cause subtle alterations in locomotor activity and consumption of saccharin-flavored solution. JF - Journal of Agricultural and Food Chemistry AU - Flynn, K M AU - Delclos, K B AU - Newbold, R R AU - Ferguson, SA AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA, sferguson@nctr.fda.gov Y1 - 2001/03/19/ PY - 2001 DA - 2001 Mar 19 SP - 1658 EP - 1665 VL - 49 IS - 3 SN - 0021-8561, 0021-8561 KW - rats KW - vinclozolin KW - Toxicology Abstracts KW - X 24132:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18409063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Behavioral+Responses+of+Rats+Exposed+to+Long-Term+Dietary+Vinclozolin&rft.au=Flynn%2C+K+M%3BDelclos%2C+K+B%3BNewbold%2C+R+R%3BFerguson%2C+SA&rft.aulast=Flynn&rft.aufirst=K&rft.date=2001-03-19&rft.volume=49&rft.issue=3&rft.spage=1658&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf0008893 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/jf0008893 ER - TY - JOUR T1 - Effect of redox modulation on xenogeneic target cells: the combination of nitric oxide and thiol deprivation protects porcine endothelial cells from lysis by IL-2-activated human NK cells. AN - 76954356; 11238660 AB - Evidence suggests that NK cells contribute to the pathogenesis of delayed rejection of vascularized xenografts, and NK cells have been suggested to participate in hyperacute xenograft rejection. Endothelial cells have been shown to be the primary target of the recipient's immune responses that mediate both hyperacute and delayed xenograft rejection. Under conditions of oxidative stress induced by thiol deprivation, but not under normal conditions, pretreatment of porcine aortic endothelial cells (PAECs) with the NO donor, S-nitroso-N-acetyl-penicillamine, dramatically inhibited killing of PAEC target cells by IL-2-activated human NK cells. This same combined treatment reduced both surface expression and mRNA levels of E-selectin. Moreover, anti-E-selectin mAb, but not Ab to VCAM-1, protected PAEC from lysis by human IL-2-activated NK cells in a dose-dependent manner. These findings suggest that expression of porcine E-selectin is important for the cytotoxicity of PAEC mediated by activated human NK cells and may be involved in the redox-mediated modulation of that cytotoxicity. It is known that NF-kappa B activation is required for transcription of E-selectin, and the current data show that the suppression of E-selectin expression by S-nitroso-N-acetyl-penicillamine pretreatment and thiol deprivation was associated with reduced NF-kappa B DNA-binding activity in PAEC. These data suggest that the regulation of porcine E-selectin may be important for modulating delayed xenograft rejection and that manipulation of cellular redox systems may provide a means to protect xenogeneic endothelial cells from NK cell-mediated cytotoxicity. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Tsuyuki, S AU - Horvath-Arcidiacono, J A AU - Bloom, E T AD - Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2001/03/15/ PY - 2001 DA - 2001 Mar 15 SP - 4106 EP - 4114 VL - 166 IS - 6 SN - 0022-1767, 0022-1767 KW - Antibodies, Blocking KW - 0 KW - Antibodies, Monoclonal KW - Culture Media KW - E-Selectin KW - Interleukin-2 KW - NF-kappa B KW - Nitric Oxide Donors KW - RNA, Messenger KW - Sulfhydryl Compounds KW - Nitric Oxide KW - 31C4KY9ESH KW - S-Nitroso-N-Acetylpenicillamine KW - 79032-48-7 KW - DNA KW - 9007-49-2 KW - NOS2 protein, human KW - EC 1.14.13.39 KW - Nitric Oxide Synthase KW - Nitric Oxide Synthase Type II KW - Glutathione KW - GAN16C9B8O KW - Penicillamine KW - GNN1DV99GX KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Penicillamine -- analogs & derivatives KW - Penicillamine -- pharmacology KW - Immunity, Innate -- drug effects KW - Humans KW - E-Selectin -- biosynthesis KW - Antibodies, Monoclonal -- pharmacology KW - Cytotoxicity, Immunologic -- immunology KW - RNA, Messenger -- biosynthesis KW - Nitric Oxide Synthase -- biosynthesis KW - Culture Media -- metabolism KW - Oxidation-Reduction KW - Nitric Oxide Donors -- pharmacology KW - Cell Membrane -- immunology KW - E-Selectin -- immunology KW - Glutathione -- antagonists & inhibitors KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - DNA -- antagonists & inhibitors KW - Cytotoxicity, Immunologic -- drug effects KW - Down-Regulation -- drug effects KW - NF-kappa B -- antagonists & inhibitors KW - Swine KW - Cell Membrane -- drug effects KW - Aorta KW - Antibodies, Blocking -- pharmacology KW - DNA -- metabolism KW - Glutathione -- metabolism KW - Intracellular Fluid -- metabolism KW - Down-Regulation -- immunology KW - RNA, Messenger -- antagonists & inhibitors KW - Cells, Cultured KW - Protein Binding -- drug effects KW - Cell Membrane -- metabolism KW - E-Selectin -- genetics KW - NF-kappa B -- metabolism KW - Cytotoxicity Tests, Immunologic -- methods KW - Interleukin-2 -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Sulfhydryl Compounds -- metabolism KW - Endothelium, Vascular -- cytology KW - Nitric Oxide -- physiology KW - Endothelium, Vascular -- immunology KW - Killer Cells, Natural -- drug effects KW - Killer Cells, Natural -- enzymology KW - Lymphocyte Activation -- drug effects KW - Endothelium, Vascular -- drug effects KW - Killer Cells, Natural -- metabolism KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76954356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Effect+of+redox+modulation+on+xenogeneic+target+cells%3A+the+combination+of+nitric+oxide+and+thiol+deprivation+protects+porcine+endothelial+cells+from+lysis+by+IL-2-activated+human+NK+cells.&rft.au=Tsuyuki%2C+S%3BHorvath-Arcidiacono%2C+J+A%3BBloom%2C+E+T&rft.aulast=Tsuyuki&rft.aufirst=S&rft.date=2001-03-15&rft.volume=166&rft.issue=6&rft.spage=4106&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-17 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Late normal tissue injury from permanent interstitial implants. AN - 70680198; 11240260 AB - To develop a simple method of calculating biologically effective doses in high-dose regions of permanent interstitial implants. The incomplete repair model is used to clarify the relationship between dose, D, and biologically effective dose (BED), for permanent interstitial implants. The relationship is used to ascertain the BED at high-dose regions that may occur in (125)I, (103)Pd, and (198)Au prostate implants. The relationship between D and BED is nonlinear and is given by BED(D) = D + D(2)/D(lambda), where D(lambda) = [(t(lambda)/t(mu)) + 1](alpha/beta), t(lambda) and t(mu) are the half-lives of the isotope and of sublethal damage repair respectively, and alpha/beta is the alpha:beta ratio. Idealized geometrically identical (125)I, (103)Pd, and (198)Au prostate implants with minimum target dose (MTD) of 160 Gy, 120 Gy, and 64 Gy, respectively, are considered. The BED for (103)Pd and (198)Au will be less than the BED for (125)I, for doses up to about 2.5 times the MTD. For higher doses, the BED for (103)Pd may be significantly higher than for (125)I. Permanent interstitial implants using short-lived isotopes may have regions with very high biologically effective doses. JF - International journal of radiation oncology, biology, physics AU - Yaes, R J AD - Division of Medical Imaging and Radiopharmaceutical Drug Products, Center For Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD, USA. yaesr@cder.fda.gov Y1 - 2001/03/15/ PY - 2001 DA - 2001 Mar 15 SP - 1163 EP - 1169 VL - 49 IS - 4 SN - 0360-3016, 0360-3016 KW - Gold Radioisotopes KW - 0 KW - Iodine Radioisotopes KW - Radioisotopes KW - Palladium KW - 5TWQ1V240M KW - Index Medicus KW - Half-Life KW - Radiotherapy Dosage KW - Humans KW - Linear Models KW - Relative Biological Effectiveness KW - Radioisotopes -- adverse effects KW - Brachytherapy -- adverse effects KW - Iodine Radioisotopes -- adverse effects KW - Brachytherapy -- methods KW - Algorithms KW - Gold Radioisotopes -- adverse effects KW - Palladium -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70680198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Late+normal+tissue+injury+from+permanent+interstitial+implants.&rft.au=Yaes%2C+R+J&rft.aulast=Yaes&rft.aufirst=R&rft.date=2001-03-15&rft.volume=49&rft.issue=4&rft.spage=1163&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histamine poisoning associated with eating tuna burgers. AN - 76981084; 11255388 AB - Histamine poisoning occurs when persons ingest fish in which bacteria have converted histidine to histamine, a process that usually can be controlled by storage at low temperatures. From 1994 to 1997, North Carolina averaged 2 cases annually; however, from July 1998 to February 1999, a total of 22 cases of histamine fish poisoning were reported. To examine the increase in histamine case reports, identify risk factors for poisoning, and develop recommendations for prevention. Case series evaluated in North Carolina from July 1998 to February 1999. Reported case-patients with 2 of the following symptoms within 2 hours of eating tuna: rash, facial flushing, vomiting, diarrhea, dyspnea, a tight feeling in the throat, headache, or a metallic or peppery taste in the mouth. Twenty cases occurred during 5 outbreaks, and there were 2 single occurrences. Of the 22 persons affected, 19 (86%) sought emergency medical care. All case-patients ate tuna: 18 ate tuna burgers, 2 ate salad containing tuna, and 2 ate filets. Tuna samples (available from 3 outbreaks) had histamine levels above the Food and Drug Administration regulatory level of 50 ppm (levels were between 213 and 3245 ppm). In 19 cases, the tuna used to prepare burgers or salads was frozen and thawed more than once before serving. Violations of recommended temperature controls were identified in 2 of the 5 restaurants, accounting for 14 (64%) cases. Tuna burgers, a relatively new menu item in restaurants, were associated with an increase in histamine poisoning cases in North Carolina. Tuna ground for burgers can be susceptible to both temperature fluctuations and bacterial contamination. JF - JAMA AU - Becker, K AU - Southwick, K AU - Reardon, J AU - Berg, R AU - MacCormack, J N AD - Office of International and Refugee Health, US Department of Health and Human Services, 5600 Fishers Ln, Parklawn Bldg, Room 18-105, Rockville, MD 20857, USA. kbecker@osophs.dhhs.gov Y1 - 2001/03/14/ PY - 2001 DA - 2001 Mar 14 SP - 1327 EP - 1330 VL - 285 IS - 10 SN - 0098-7484, 0098-7484 KW - Histamine KW - 820484N8I3 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - North Carolina -- epidemiology KW - Disease Outbreaks KW - Food Preservation KW - Seafood -- poisoning KW - Tuna KW - Foodborne Diseases -- epidemiology KW - Histamine -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76981084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Histamine+poisoning+associated+with+eating+tuna+burgers.&rft.au=Becker%2C+K%3BSouthwick%2C+K%3BReardon%2C+J%3BBerg%2C+R%3BMacCormack%2C+J+N&rft.aulast=Becker&rft.aufirst=K&rft.date=2001-03-14&rft.volume=285&rft.issue=10&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2001 Jun 20;285(23):2977-8 [11410093] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - From the Food and Drug Administration. AN - 76980032; 11231734 JF - JAMA AU - Schwetz, B A AD - Food and Drug Administration, USA. Y1 - 2001/03/07/ PY - 2001 DA - 2001 Mar 07 SP - 1146 VL - 285 IS - 9 SN - 0098-7484, 0098-7484 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antineoplastic Agents KW - Dermatologic Agents KW - Nitriles KW - Suppositories KW - Triazoles KW - Mesalamine KW - 4Q81I59GXC KW - letrozole KW - 7LKK855W8I KW - Isotretinoin KW - EH28UP18IF KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Risk KW - United States Food and Drug Administration KW - Humans KW - Breast Neoplasms -- drug therapy KW - Information Services KW - Isotretinoin -- adverse effects KW - Mesalamine -- administration & dosage KW - Clinical Trials as Topic KW - Triazoles -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- administration & dosage KW - Nitriles -- therapeutic use KW - Dermatologic Agents -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Colitis, Ulcerative -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76980032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=From+the+Food+and+Drug+Administration.&rft.au=Schwetz%2C+B+A&rft.aulast=Schwetz&rft.aufirst=B&rft.date=2001-03-07&rft.volume=285&rft.issue=9&rft.spage=1146&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A numerical method to predict the effects of frequency-dependent attenuation and dispersion on speed of sound estimates in cancellous bone. AN - 85365885; pmid-11303934 AB - Many studies have demonstrated that time-domain speed-of-sound (SOS) measurements in calcaneus are predictive of osteoporotic fracture risk. However, there is a lack of standardization for this measurement. Consequently, different investigators using different measurement systems and analysis algorithms obtain disparate quantitative values for calcaneal SOS, impairing and often precluding meaningful comparison and/or pooling of measurements. A numerical method has been developed to model the effects of frequency-dependent attenuation and dispersion on transit-time-based SOS estimates. The numerical technique is based on a previously developed linear system analytic model for Gaussian pulses propagating through linearly attenuating, weakly dispersive media. The numerical approach is somewhat more general in that it can be used to predict the effects of arbitrary pulse shapes and dispersion relationships. The numerical technique, however, utilizes several additional assumptions (compared with the analytic model) which would be required for the practical task of correcting existing clinical databases. These include a single dispersion relationship for all calcaneus samples, a simple linear model relating phase velocity to broadband ultrasonic attenuation, and a constant calcaneal thickness. Measurements on a polycarbonate plate and 30 human calcaneus samples were in good quantitative agreement with numerical predictions. In addition, the numerical approach predicts that in cancellous bone, frequency-dependent attenuation tends to be a greater contributor to variations in transit-time-based SOS estimates than dispersion. This approach may be used to adjust previously acquired individual measurements so that SOS data recorded with different devices using different algorithms may be compared in a meaningful fashion. JF - The Journal of the Acoustical Society of America AU - Wear, K A AD - US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, Maryland 20852, USA. kaw@cdrh.fda.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 1213 EP - 1218 VL - 109 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - *Calcaneus: ultrasonography KW - Fractures, Bone: diagnosis KW - Humans KW - *Models, Biological KW - Osteoporosis: diagnosis KW - Predictive Value of Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85365885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=A+numerical+method+to+predict+the+effects+of+frequency-dependent+attenuation+and+dispersion+on+speed+of+sound+estimates+in+cancellous+bone.&rft.au=Wear%2C+K+A&rft.aulast=Wear&rft.aufirst=K&rft.date=2001-03-01&rft.volume=109&rft.issue=3&rft.spage=1213&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Interspecies scaling of maximum tolerated dose of anticancer drugs: relevance to starting dose for phase I clinical trials. AN - 77061860; 11304664 AB - This analysis was carried out to compare the predictive performance of two different approaches of allometry for the prediction of maximum tolerated dose (MTD) in humans from animal data. The two approaches used to predict MTD in humans in this analysis were (1) the use of a fixed exponent of 0.75 and the LD(10) in mice and (2) the use of the LD(10) or MTD data from at least three animal species (interspecies scaling). Twenty-five anticancer drugs were taken from the literature and used in this analysis. The results of the study indicate that MTD can be predicted more accurately using interspecies scaling than using a fixed exponent of 0.75. Incorporation of a correction factor known as mean life-span potential can also be used for the improved prediction of MTD for some drugs. One third of the predicted MTD from interspecies scaling can be used as a starting dose in humans. This approach will save time and avoid many unnecessary steps in attaining MTD in humans. JF - American journal of therapeutics AU - Mahmood, I AD - Division of Pharmaceutical Evaluation I, Office of Clinical Pharmacology and Biopharmaceutics, U.S. Food and Drug Administration, Rockville, MD 20852, USA. Mahmoodi@cder.fda.gov PY - 2001 SP - 109 EP - 116 VL - 8 IS - 2 SN - 1075-2765, 1075-2765 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Rats KW - Models, Animal KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Dogs KW - Predictive Value of Tests KW - Mice KW - Models, Biological KW - Antineoplastic Agents -- administration & dosage KW - Clinical Trials, Phase I as Topic KW - Antineoplastic Agents -- pharmacokinetics KW - Maximum Tolerated Dose KW - Species Specificity KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77061860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Interspecies+scaling+of+maximum+tolerated+dose+of+anticancer+drugs%3A+relevance+to+starting+dose+for+phase+I+clinical+trials.&rft.au=Mahmood%2C+I&rft.aulast=Mahmood&rft.aufirst=I&rft.date=2001-03-01&rft.volume=8&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=10752765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Violent traumatic events and drug abuse severity. AN - 77061532; 11306214 AB - We examined the occurrence of violent traumatic events, DSM-III-R diagnosis of posttraumatic stress disorder (PTSD), and PTSD symptoms, and the relationship of these variables to drug abuse severity. One-hundred fifty opioid-dependent drug abusers who were participants in a randomized trial of two methadone treatment interventions were interviewed using the Diagnostic Interview Schedule, the Addiction Severity Index, and the Beck Depression Inventory. Twenty-nine percent met diagnostic criteria for PTSD. With the exception of rape, no gender differences in the prevalence of violent traumatic events were observed. The occurrence of PTSD-related symptoms was associated with greater drug abuse severity after controlling for gender, depression, and lifetime diagnosis of PTSD. The high rate of PTSD among these methadone patients, the nature of the traumatic events to which they are exposed, and subsequent violence-related psychiatric sequelae have important implications for identification and treatment of PTSD among those seeking drug abuse treatment. JF - Journal of substance abuse treatment AU - Clark, H W AU - Masson, C L AU - Delucchi, K L AU - Hall, S M AU - Sees, K L AD - Department of Psychiatry, Langley Porter Psychiatric Institute, University of California-San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA. wclark@samhsa.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 121 EP - 127 VL - 20 IS - 2 SN - 0740-5472, 0740-5472 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Combined Modality Therapy KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Middle Aged KW - Socioenvironmental Therapy KW - Male KW - Female KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- psychology KW - Heroin Dependence -- diagnosis KW - Violence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77061532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Violent+traumatic+events+and+drug+abuse+severity.&rft.au=Clark%2C+H+W%3BMasson%2C+C+L%3BDelucchi%2C+K+L%3BHall%2C+S+M%3BSees%2C+K+L&rft.aulast=Clark&rft.aufirst=H&rft.date=2001-03-01&rft.volume=20&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tissue sphinganine as a biomarker of fumonisin-induced apoptosis. AN - 77051147; 11304034 AB - NCTR measured sphinganine concentrations in the livers of mice and in the livers and kidneys of rats in conjunction with a tumour bioassay. In our model of the tumour incidence, target-tissue levels of sphinganine serve as a biomarker for a dose response of fumonisin B1 on cell death. Initially we questioned the utility of sphinganine levels in this role because they were highly variable when compared across time points. In spite of this concern, a conceptual framework and data are presented that support the use of sphinganine as a biomarker for a dose response of fumonisin B1 on cell death. This framework is reasonably consistent with observed sphinganine concentrations in the examined tissues, the literature on fumonisin's effects on sphingolipid synthesis, and our hypothesized mechanism through which fumonisin B1 increases age-specific tumour incidence. JF - Food additives and contaminants AU - Delongchamp, R R AU - Young, J F AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. rdelongchamp@nctr.fda.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 255 EP - 261 VL - 18 IS - 3 SN - 0265-203X, 0265-203X KW - Biomarkers KW - 0 KW - Carboxylic Acids KW - Carcinogens, Environmental KW - Enzyme Inhibitors KW - Fumonisins KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Sphingosine KW - NGZ37HRE42 KW - safingol KW - OWA98U788S KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Mycotoxins -- pharmacology KW - Dose-Response Relationship, Drug KW - Mycotoxins -- blood KW - Kidney -- drug effects KW - Mice KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Protein Kinase C -- antagonists & inhibitors KW - Cell Survival -- drug effects KW - Half-Life KW - Biomarkers -- analysis KW - Food Contamination KW - Female KW - Male KW - Liver -- cytology KW - Sphingosine -- metabolism KW - Liver -- drug effects KW - Apoptosis -- physiology KW - Apoptosis -- drug effects KW - Carcinogens, Environmental -- metabolism KW - Carboxylic Acids -- pharmacology KW - Carboxylic Acids -- blood KW - Liver -- metabolism KW - Enzyme Inhibitors -- metabolism KW - Sphingosine -- analogs & derivatives KW - Carcinogens, Environmental -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77051147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Tissue+sphinganine+as+a+biomarker+of+fumonisin-induced+apoptosis.&rft.au=Delongchamp%2C+R+R%3BYoung%2C+J+F&rft.aulast=Delongchamp&rft.aufirst=R&rft.date=2001-03-01&rft.volume=18&rft.issue=3&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A quantitative risk assessment for fumonisins B1 and B2 in US corn. AN - 77050729; 11304030 AB - Quantitative risk analysis permits modifying risk estimates with changes in variables such as exposure. This analysis for exposure to the mycotoxin fumonism describes the magnitude of adverse effects, variability in the population and uncertainty of models as a range of possible outcomes. The most sensitive adverse response in rats, nephrotoxic lesions, was used for the dose-response analysis. Dietary intake of corn products was estimated from a 3-day consumption survey. Levels of corn in each product were estimated by standard methods. Fumonisin levels in corn products were estimated from Food and Drug Administration (FDA) surveillance data and distributions of fumonisin consumption were modelled for each eater in the survey population. Uncertainty for predictions made from each model and uncertainty resulting from model selection were described. Results of the dose-response and exposure analyses were assimilated in a two-dimensional Monte-Carlo simulation. Distributions representing variability and uncertainty were iteratively selected to form an array of estimates of the risk. On the basis of this analysis, current dietary levels of fumonisin would not result in renal lesions even at upper levels of exposure. To avoid toxicity at much higher doses, limiting corn intake would be more effective than would limiting the level of fumonisin in corn. JF - Food additives and contaminants AU - Humphreys, S H AU - Carrington, C AU - Bolger, M AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. shumphre@cfsan.fda.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 211 EP - 220 VL - 18 IS - 3 SN - 0265-203X, 0265-203X KW - Carboxylic Acids KW - 0 KW - Carcinogens, Environmental KW - Fumonisins KW - Mycotoxins KW - fumonisin B2 KW - 116355-84-1 KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - United States KW - Software KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Risk Assessment -- methods KW - Monte Carlo Method KW - Rats KW - Mycotoxins -- administration & dosage KW - Diet KW - Female KW - Male KW - Mycotoxins -- analysis KW - Mycotoxins -- toxicity KW - Kidney Diseases -- chemically induced KW - Carcinogens, Environmental -- administration & dosage KW - Carboxylic Acids -- administration & dosage KW - Zea mays -- chemistry KW - Food Contamination KW - Carcinogens, Environmental -- toxicity KW - Carcinogens, Environmental -- analysis KW - Carboxylic Acids -- analysis KW - Carboxylic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77050729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=A+quantitative+risk+assessment+for+fumonisins+B1+and+B2+in+US+corn.&rft.au=Humphreys%2C+S+H%3BCarrington%2C+C%3BBolger%2C+M&rft.aulast=Humphreys&rft.aufirst=S&rft.date=2001-03-01&rft.volume=18&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet. AN - 77048133; 11304033 AB - Data from the National Toxicology Program's carcinogenesis study of fumonisin B1 in B6C3F1 mice, conducted at the National Center for Toxicological Research, were used to fit the Moolgavkar-Venzon-Knudson (MVK) two-stage, clonal-expansion model of carcinogenesis. In addition to tumour data from the conventional 2-year bioassay, the study included data on tissue weights, cell proliferation, cell death, and sphingolipid metabolism in primary target organs. The model was used to predict 2-year liver tumour rates in female and male mice based on differences among dose groups in the effect of fumonisin B1 on the growth of normal tissue and on the proliferation of preneoplastic cells as a compensatory response to sphinganine-induced cell death. Fumonisin B1 was assumed to be non-genotoxic, i.e. the model did not include any effect of fumonisin B1 on either of the two mutation rates of the MVK model. The model was able to reproduce reasonably well the observed tumour rates in both female and male mice, predicting substantially increased rates above background only at the highest doses of fumonisin B1 in females. JF - Food additives and contaminants AU - Kodell, R L AU - Young, J F AU - Delongchamp, R R AU - Turturro, A AU - Chen, J J AU - Gaylor, D W AU - Howard, P C AU - Zheng, Q AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Rkodell@nctr.fda.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 237 EP - 253 VL - 18 IS - 3 SN - 0265-203X, 0265-203X KW - Carboxylic Acids KW - 0 KW - Carcinogens, Environmental KW - Fumonisins KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Sphingosine KW - NGZ37HRE42 KW - safingol KW - OWA98U788S KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Cell Division -- drug effects KW - Liver -- metabolism KW - Mice KW - Risk Assessment -- methods KW - Cell Death -- drug effects KW - Body Weight KW - Mice, Inbred Strains KW - Mycotoxins -- toxicity KW - Cell Transformation, Neoplastic KW - Female KW - Male KW - Organ Size -- drug effects KW - Sphingosine -- metabolism KW - Food Contamination KW - Liver Neoplasms, Experimental -- chemically induced KW - Carcinogens, Environmental -- toxicity KW - Models, Biological KW - Sphingosine -- analogs & derivatives KW - Carboxylic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77048133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=A+mechanistic+approach+to+modelling+the+risk+of+liver+tumours+in+mice+exposed+to+fumonisin+B1+in+the+diet.&rft.au=Kodell%2C+R+L%3BYoung%2C+J+F%3BDelongchamp%2C+R+R%3BTurturro%2C+A%3BChen%2C+J+J%3BGaylor%2C+D+W%3BHoward%2C+P+C%3BZheng%2C+Q&rft.aulast=Kodell&rft.aufirst=R&rft.date=2001-03-01&rft.volume=18&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metal exposure during ship repair and shipbreaking procedures. AN - 77043431; 11297046 JF - Applied occupational and environmental hygiene AU - Mattorano, D AU - Harney, J AU - Cook, C AU - Roegner, K AD - Hazard Evaluation and Technical Assistance Branch of NIOSH, Cincinnati, OH 45226, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 339 EP - 349 VL - 16 IS - 3 SN - 1047-322X, 1047-322X KW - Air Pollutants KW - 0 KW - Metals, Heavy KW - Index Medicus KW - United States KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Welding KW - Organizational Case Studies KW - Ships KW - Occupational Exposure -- prevention & control KW - Paint -- analysis KW - Air Pollutants -- analysis KW - Paint -- adverse effects KW - Occupational Exposure -- analysis KW - Metals, Heavy -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77043431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Metal+exposure+during+ship+repair+and+shipbreaking+procedures.&rft.au=Mattorano%2C+D%3BHarney%2C+J%3BCook%2C+C%3BRoegner%2C+K&rft.aulast=Mattorano&rft.aufirst=D&rft.date=2001-03-01&rft.volume=16&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substance abuse and child welfare: clear linkages and promising responses. AN - 77037436; 11291897 AB - Parental substance abuse is a significant factor in many of the families served in the child welfare system. This article examines: (1) the prevalence of substance abuse among families involved with the child welfare system; (2) the impact of substance abuse on child welfare practice; (3) how both the Adoption and Safe Families Act of 1997 and welfare reform legislation intensify the need to address parental substance abuse effectively; and (4) promising strategies for addressing these families' needs. JF - Child welfare AU - Semidei, J AU - Radel, L F AU - Nolan, C AD - US Children's Bureau, US Department of Health and Human Services, Washington, DC, USA. PY - 2001 SP - 109 EP - 128 VL - 80 IS - 2 SN - 0009-4021, 0009-4021 KW - Index Medicus KW - Alcoholism -- epidemiology KW - Humans KW - Adult KW - United States -- epidemiology KW - Prevalence KW - Child, Preschool KW - Child Welfare -- legislation & jurisprudence KW - Parents KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77037436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=Substance+abuse+and+child+welfare%3A+clear+linkages+and+promising+responses.&rft.au=Semidei%2C+J%3BRadel%2C+L+F%3BNolan%2C+C&rft.aulast=Semidei&rft.aufirst=J&rft.date=2001-03-01&rft.volume=80&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residential substance abuse treatment for pregnant and postpartum women and their children: treatment and policy implications. AN - 77036379; 11291900 AB - In FY 1993 and FY 1995, the federal government awarded 27 five-year grants that supported 35 residential treatment projects for substance-abusing pregnant and postpartum women and their children. These projects provided comprehensive culturally and gender-specific treatment. Preliminary aggregated data collected in a national cross-site evaluation of 24 of these projects are encouraging with respect to infant mortality and morbidity, treatment retention and completion rates, and behavioral changes in the participating mothers at six months postdischarge. Local evaluations reflect other benefits of treatment. Cost data are expected to demonstrate the efficiencies and benefits of these projects compared to no treatment. JF - Child welfare AU - Clark, H W AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA. PY - 2001 SP - 179 EP - 198 VL - 80 IS - 2 SN - 0009-4021, 0009-4021 KW - Index Medicus KW - United States KW - Infant KW - Crime KW - Humans KW - Adult KW - Treatment Outcome KW - Infant, Newborn KW - Infant, Premature KW - Female KW - Pregnancy KW - Child, Preschool KW - Substance-Related Disorders -- therapy KW - Substance Abuse Treatment Centers -- organization & administration KW - Substance Abuse Treatment Centers -- economics KW - Child Welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77036379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=Residential+substance+abuse+treatment+for+pregnant+and+postpartum+women+and+their+children%3A+treatment+and+policy+implications.&rft.au=Clark%2C+H+W&rft.aulast=Clark&rft.aufirst=H&rft.date=2001-03-01&rft.volume=80&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic mercury exposure examined with a computer-based tremor system. AN - 77019961; 11285879 AB - Tremor is being increasingly evaluated by quantitative computer-based systems to differentiate its causes. In this study, a group of mercury-exposed workers were assessed to determine whether tremor characteristics differed by exposure level. Workers were classified into two groups: those with an average urine mercury concentration below the American Conference of Government Industrial Hygienist Biological Exposure Index of 35 micrograms/g creatinine, and those with an average urine mercury concentration above the Biological Exposure Index. Tremor characteristics (including intensity, harmonic index, center frequency, standard deviation of the center frequency, and tremor index) were measured and recorded with a computer-based tremor system. Sixteen of 17 workers who were potentially exposed to mercury participated in the study. Three workers had a mean urine mercury concentration of 27.0 micrograms/g-creatinine and were assigned to the low-exposure group, and 13 workers had a mean urine mercury concentration of 200.2 micrograms/g-creatinine and were assigned to the high-exposure group. There was a statistically significant difference in the tremor index (which compiles five individual tremor parameters into a single value) between the two groups (P = 0.04; Wilcoxon's rank sum test). Other tremor characteristics did not differ significantly between the groups. Tremor index may be more useful than measures of individual tremor parameters in differentiating normal from subclinical pathological tremors among groups of workers with chronic mercury exposure. JF - Journal of occupational and environmental medicine AU - McCullough, J E AU - Dick, R AU - Rutchik, J AD - National Institute for Occupational Safety and Health, OH, USA. zzm3@cdc.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 295 EP - 300 VL - 43 IS - 3 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Diagnosis, Computer-Assisted KW - Mercury Poisoning -- urine KW - Tremor -- diagnosis KW - Mercury Poisoning -- diagnosis KW - Tremor -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77019961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Chronic+mercury+exposure+examined+with+a+computer-based+tremor+system.&rft.au=McCullough%2C+J+E%3BDick%2C+R%3BRutchik%2C+J&rft.aulast=McCullough&rft.aufirst=J&rft.date=2001-03-01&rft.volume=43&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trends in mental health services use and spending, 1987-1996. AN - 76989073; 11260946 JF - Health affairs (Project Hope) AU - Zuvekas, S H AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland, USA. PY - 2001 SP - 214 EP - 224 VL - 20 IS - 2 SN - 0278-2715, 0278-2715 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - United States KW - Humans KW - Psychotropic Drugs -- therapeutic use KW - Aged KW - Ambulatory Care -- utilization KW - Child KW - Substance-Related Disorders -- economics KW - Health Services Accessibility KW - Adult KW - Middle Aged KW - Adolescent KW - Utilization Review KW - Drug Utilization Review KW - Female KW - Male KW - Health Expenditures -- statistics & numerical data KW - Financing, Personal -- statistics & numerical data KW - Mental Health Services -- utilization KW - Health Expenditures -- trends KW - Mental Health Services -- economics KW - Financing, Personal -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76989073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+affairs+%28Project+Hope%29&rft.atitle=Trends+in+mental+health+services+use+and+spending%2C+1987-1996.&rft.au=Zuvekas%2C+S+H&rft.aulast=Zuvekas&rft.aufirst=S&rft.date=2001-03-01&rft.volume=20&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Health+affairs+%28Project+Hope%29&rft.issn=02782715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid declines in FEV1 and subsequent respiratory symptoms, illnesses, and mortality in coal miners in the United States. AN - 76979826; 11254516 AB - Coal mine dust exposure is associated with accelerated loss of lung function. We assessed long-term health outcomes in two groups of underground coal miners who during previous mine surveys had shown either high rates of FEV1 decline (cases, n = 310) or relatively stable lung function (referents, n = 324). Cases and referents were matched initially for age, height, smoking status, and FEV1. We determined vital status for 561 miners, and obtained a follow-up questionnaire for 121 cases and 143 referents. Responses on the follow-up questionnaire were compared with those on the last previous mine health survey questionnaire. Cases showed a greater incidence of symptoms than did referents for cough, phlegm production, Grades II and III dyspnea, and wheezing, and greater incidences than referents of chronic bronchitis and self- reported asthma and emphysema. More cases than referents (15% versus 4%) left mining before retirement because of chest illnesses. After controls were applied for age and smoking, cases had twice the risk of dying of cardiovascular and nonmalignant respiratory diseases and a 3.2-fold greater risk of dying of chronic obstructive pulmonary disease than did referents. Rapid declines in FEV1 experienced by some coal miners are associated with subsequent increases in respiratory symptoms, illnesses, and mortality from cardiovascular and nonmalignant respiratory diseases. JF - American journal of respiratory and critical care medicine AU - Beeckman, L A AU - Wang, M L AU - Petsonk, E L AU - Wagner, G R AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Morgantown, West Virginia 26505-2888, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 633 EP - 639 VL - 163 IS - 3 Pt 1 SN - 1073-449X, 1073-449X KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Surveys and Questionnaires KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Male KW - Lung Diseases -- etiology KW - Occupational Diseases -- etiology KW - Occupational Diseases -- physiopathology KW - Lung Diseases -- physiopathology KW - Coal Mining KW - Lung Diseases -- mortality KW - Forced Expiratory Volume KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76979826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Rapid+declines+in+FEV1+and+subsequent+respiratory+symptoms%2C+illnesses%2C+and+mortality+in+coal+miners+in+the+United+States.&rft.au=Beeckman%2C+L+A%3BWang%2C+M+L%3BPetsonk%2C+E+L%3BWagner%2C+G+R&rft.aulast=Beeckman&rft.aufirst=L&rft.date=2001-03-01&rft.volume=163&rft.issue=3+Pt+1&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Respir Crit Care Med. 2002 Feb 15;165(4):552-3; author reply 553 [11850352] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fidelity of replication of repetitive DNA in mutS and repair proficient Escherichia coli. AN - 76958815; 11239958 AB - Replication fidelity is not constant among strains within a species or at all genetic loci within a genome. Altered fidelity of replication may affect patterns of pathogenesis and the evolution of these strains. We have been studying replication fidelity in Escherichia coli, both in laboratory attenuated strains and in food-borne pathogens. To understand the altered patterns of mutagenesis at the molecular level, we used a shuttle vector plasmid with a tRNA mutational marker gene which had been altered to include homopolymeric runs of five, seven and nine [G:C] pairs, as well as non-repetitive DNA. Replication of the plasmid in mutS strains resulted in a 20-fold increase in mutant progeny plasmids. The mutations were almost all (>90%) frameshift mutations, while base substitution mutations were rare. Most mutations were insertions or deletions of one or two [G:C] pairs in the longest homopolymeric runs. Larger deletions (5 to >70bp), also targeted to the repetitive sequence, were likewise common. Mutations increased exponentially with the length of the homopolymeric run. These patterns of mutation, including unexpectedly high levels in repair proficient strains, led to an examination of the E. coli K-12 genome for homopolymeric DNA. This sequence motif was found to be rare, particularly in genes and open reading frames. Amino acid homotrimers were found to avoid usage of homopolymeric codons, even when they are preferred among synonymous codons in E. coli. There appears to be active selection against tandem direct nucleotide repeats in the E. coli genome, correlated with the inability of the organism to accurately replicate such sequence. JF - Mutation research AU - Levy, D D AU - Cebula, T A AD - Molecular Biology Branch (HFS-237), Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street, Washington, DC 20204, USA. Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 1 EP - 14 VL - 474 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - DNA-Binding Proteins KW - Escherichia coli Proteins KW - RNA, Bacterial KW - RNA, Transfer KW - 9014-25-9 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - MutS DNA Mismatch-Binding Protein KW - EC 3.6.1.3 KW - MutS protein, E coli KW - Index Medicus KW - Base Sequence KW - RNA, Transfer -- genetics KW - Molecular Sequence Data KW - RNA, Bacterial -- genetics KW - Mutation KW - DNA Replication -- genetics KW - Bacterial Proteins -- genetics KW - DNA Repair KW - DNA, Bacterial -- biosynthesis KW - Escherichia coli -- genetics KW - Repetitive Sequences, Nucleic Acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76958815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Fidelity+of+replication+of+repetitive+DNA+in+mutS+and+repair+proficient+Escherichia+coli.&rft.au=Levy%2C+D+D%3BCebula%2C+T+A&rft.aulast=Levy&rft.aufirst=D&rft.date=2001-03-01&rft.volume=474&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK(+/-) human lymphoblastoid cells. AN - 76957756; 11239970 AB - Coumestrol, a phytoestrogen found in high levels in alfalfa and red clover, is of concern since endocrine disorders have been observed in farm animals exposed to high levels of phytoestrogens. Previous studies found that coumestrol was an effective inducer of DNA strand breaks, micronuclei, and mutations in the Hypoxanthine phosphoribosyl transferase (HPRT) gene of Chinese hamster ovary cells. In the experiments presented here, we extended the previous studies to examine the effect of coumestrol exposure on AHH-1 TK(+/-) human lymphoblastoid cells. Micronuclei were induced with the highest frequency occurring at day 2 after exposure. Flow cytometric analysis of annexin V-FITC-7-aminoactinomycin D stained cells indicated that the primary pathway of cell death was by apoptosis. Mutations were induced in the Thymidine Kinase (TK) gene and were due primarily to the induction of clones with the slow-growth phenotype. Subsequent molecular analysis revealed the loss of exon 4 in the coumestrol-induced clones, indicative of loss-of heterozygosity and consistent with a proposed inhibition of topoisomerase-II activity as a mechanism of action for coumestrol. Taken together, these results suggest that coumestrol exhibits both mutagenic and clastogenic properties in cultured human lymphoblastoid cells. JF - Mutation research AU - Domon, O E AU - McGarrity, L J AU - Bishop, M AU - Yoshioka, M AU - Chen, J J AU - Morris, S M AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 129 EP - 137 VL - 474 IS - 1-2 SN - 0027-5107, 0027-5107 KW - DNA Primers KW - 0 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Coumestrol KW - V7NW98OB34 KW - Index Medicus KW - Evaluation Studies as Topic KW - Clone Cells KW - Base Sequence KW - Micronucleus Tests KW - Loss of Heterozygosity KW - Humans KW - Cell Death -- drug effects KW - Mutation KW - Cell Line KW - Thymidine Kinase -- genetics KW - Coumestrol -- toxicity KW - Lymphocytes -- enzymology KW - Lymphocytes -- cytology KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76957756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Evaluation+of+the+genotoxicity+of+the+phytoestrogen%2C+coumestrol%2C+in+AHH-1+TK%28%2B%2F-%29+human+lymphoblastoid+cells.&rft.au=Domon%2C+O+E%3BMcGarrity%2C+L+J%3BBishop%2C+M%3BYoshioka%2C+M%3BChen%2C+J+J%3BMorris%2C+S+M&rft.aulast=Domon&rft.aufirst=O&rft.date=2001-03-01&rft.volume=474&rft.issue=1-2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pneumococcal type 22f polysaccharide absorption improves the specificity of a pneumococcal-polysaccharide enzyme-linked immunosorbent assay. AN - 76954861; 11238206 AB - The specificity of the immune response to the 23-valent pneumococcal-polysaccharide (PS) vaccine in healthy adults and to a pneumococcal conjugate vaccine in infants was examined by measuring immunoglobulin G (IgG) antibody titers by enzyme-linked immunosorbent assay (ELISA) and the opsonophagocytosis assay. ELISA measures total antipneumococcal IgG titers including the titers of functional and nonfunctional antibodies, while the opsonophagocytosis assay measures only functional-antibody titers. Twenty-four pairs of pre- and post-pneumococcal vaccination sera from adults were evaluated (ELISA) for levels of IgG antibodies against serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F. Twelve of the pairs were also examined (opsonophagocytosis assay) for their functional activities. The correlation coefficients between assay results for most types ranged from 0.75 to 0.90, but the correlation coefficient was only about 0.6 for serotypes 4 and 19F. The specificities of these antibodies were further examined by the use of competitive ELISA inhibition. A number of heterologous polysaccharides (types 11A, 12F, 15B, 22F, and 33A) were used as inhibitors. Most of the sera tested showed cross-reacting antibodies, in addition to those removed by pneumococcal C PS absorption. Our data suggest the presence of a common epitope that is found on most pneumococcal PS but that is not absorbed by purified C PS. Use of a heterologous pneumococcal PS (22F) to adsorb the antibodies to the common epitope increased the correlation between the IgG ELISA results and the opsonophagocytosis assay results. The correlation coefficient improve from 0.66 to 0.92 for type 4 and from 0.63 to 0.80 for type 19F. These common-epitope antibodies were largely absent in infants at 7 months of age, suggesting the carbohydrate nature of the epitope. JF - Clinical and diagnostic laboratory immunology AU - Concepcion, N F AU - Frasch, C E AD - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, Maryland, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 266 EP - 272 VL - 8 IS - 2 SN - 1071-412X, 1071-412X KW - Epitopes KW - 0 KW - Immunoglobulin G KW - Pneumococcal Vaccines KW - Index Medicus KW - Immunoglobulin G -- blood KW - Immunoglobulin G -- analysis KW - Reproducibility of Results KW - Humans KW - Binding, Competitive -- immunology KW - Adult KW - Cytotoxicity Tests, Immunologic KW - Phagocytosis -- immunology KW - Immunoglobulin G -- immunology KW - Epitopes -- immunology KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Antibody Specificity KW - Enzyme-Linked Immunosorbent Assay -- standards KW - Pneumococcal Vaccines -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76954861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+diagnostic+laboratory+immunology&rft.atitle=Pneumococcal+type+22f+polysaccharide+absorption+improves+the+specificity+of+a+pneumococcal-polysaccharide+enzyme-linked+immunosorbent+assay.&rft.au=Concepcion%2C+N+F%3BFrasch%2C+C+E&rft.aulast=Concepcion&rft.aufirst=N&rft.date=2001-03-01&rft.volume=8&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Clinical+and+diagnostic+laboratory+immunology&rft.issn=1071412X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Infect Dis. 2000 Jan;30(1):100-21 [10619740] Clin Infect Dis. 1993 Jul;17(1):66-73 [8353248] Infect Immun. 2000 Apr;68(4):2333-7 [10722638] Pediatr Infect Dis J. 2000 Mar;19(3):187-95 [10749457] Clin Diagn Lab Immunol. 2000 May;7(3):468-76 [10799463] J Exp Med. 1968 Dec 1;128(6):1385-400 [4386878] Rev Infect Dis. 1981 Mar-Apr;3(2):289-98 [7020046] Acta Pathol Microbiol Immunol Scand C. 1982 Dec;90(6):353-5 [7170960] J Infect Dis. 1986 Aug;154(2):245-56 [3722865] J Infect Dis. 1994 Sep;170(3):592-9 [8077716] J Immunol. 1995 Apr 15;154(8):4195-202 [7706754] J Infect Dis. 1995 Nov;172(5):1273-8 [7594664] J Clin Microbiol. 1995 Oct;33(10):2759-62 [8567920] Clin Diagn Lab Immunol. 1997 Jul;4(4):415-22 [9220157] Clin Diagn Lab Immunol. 1998 Mar;5(2):199-204 [9521143] Pediatrics. 1998 Apr;101(4 Pt 1):604-11 [9521941] Vaccine. 1999 Apr 9;17(15-16):1970-7 [10217596] Clin Diagn Lab Immunol. 1999 Jul;6(4):519-24 [10391854] Pediatr Infect Dis J. 1987 Jun;6(6):519-26 [3615065] J Infect Dis. 1990 Apr;161(4):736-40 [2319167] Microb Pathog. 1990 May;8(5):325-34 [2215183] J Biol Chem. 2000 Mar 17;275(11):7497-504 [10713053] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus. AN - 71160505; 11420653 AB - To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26% and 15% of the A280, respectively) were identified by mass and 1H nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin. The biological formation of desethylene-N-acetylsarafloxacin has not been previously observed. JF - Journal of industrial microbiology & biotechnology AU - Parshikov, I A AU - Freeman, J P AU - Lay, J O AU - Moody, J D AU - Williams, A J AU - Beger, R D AU - Sutherland, J B AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 140 EP - 144 VL - 26 IS - 3 SN - 1367-5435, 1367-5435 KW - Anti-Infective Agents KW - 0 KW - Fluoroquinolones KW - Soil Pollutants KW - Ciprofloxacin KW - 5E8K9I0O4U KW - sarafloxacin KW - RC3WJ907XY KW - Index Medicus KW - Animals KW - Soil Pollutants -- metabolism KW - Veterinary Medicine -- methods KW - Biodegradation, Environmental KW - Anti-Infective Agents -- metabolism KW - Ciprofloxacin -- metabolism KW - Mucor -- metabolism KW - Ciprofloxacin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71160505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Metabolism+of+the+veterinary+fluoroquinolone+sarafloxacin+by+the+fungus+Mucor+ramannianus.&rft.au=Parshikov%2C+I+A%3BFreeman%2C+J+P%3BLay%2C+J+O%3BMoody%2C+J+D%3BWilliams%2C+A+J%3BBeger%2C+R+D%3BSutherland%2C+J+B&rft.aulast=Parshikov&rft.aufirst=I&rft.date=2001-03-01&rft.volume=26&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=13675435&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of musk ambrette, musk xylol, and musk ketone in fragrance products by capillary gas chromatography with electron capture detection. AN - 70800737; 11324601 AB - A gas chromatographic method using a capillary column with electron capture detection was developed for the simultaneous determination of 3 nitromusk fragrance ingredients: musk ambrette (MA), musk xylol (MX), and musk ketone (MK), in fragrance products. The accuracy of the method was determined by recovery of each nitromusk from fortified fragrance products at 3 different concentrations. Recoveries ranged from 95.0 to 105.9% for MA, 88.4 to 102.5% for MX, and 93.7 to 103.7% for MK. The method was used to survey 30 fragrance products purchased in the Washington, DC, area for each of the nitromusks. MA was not found in any of the products. MX was found in 9 products at levels ranging from 0.001 to 0.22%; MK was found in 8 products at levels ranging from 0.023 to 0.45%. The presence of MX and MK was confirmed by gas chromatography/mass spectrometry in many of the fragrance products. JF - Journal of AOAC International AU - Wisneski, H H AD - US Food and Drug Administration, Washington, DC 20204, USA. PY - 2001 SP - 376 EP - 381 VL - 84 IS - 2 SN - 1060-3271, 1060-3271 KW - Dinitrobenzenes KW - 0 KW - Fatty Acids, Monounsaturated KW - Indicators and Reagents KW - Ketones KW - Perfume KW - musk KW - 095I377U8F KW - musk ambrette (artificial) KW - 83-66-9 KW - Index Medicus KW - Chromatography, Gas KW - Reference Standards KW - Gas Chromatography-Mass Spectrometry KW - Perfume -- analysis KW - Fatty Acids, Monounsaturated -- chemistry KW - Ketones -- analysis KW - Dinitrobenzenes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70800737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+musk+ambrette%2C+musk+xylol%2C+and+musk+ketone+in+fragrance+products+by+capillary+gas+chromatography+with+electron+capture+detection.&rft.au=Wisneski%2C+H+H&rft.aulast=Wisneski&rft.aufirst=H&rft.date=2001-03-01&rft.volume=84&rft.issue=2&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid methods to enumerate Escherichia coli in foods using 4-methylumbelliferyl-beta-D-glucuronide. AN - 70799619; 11324605 AB - Three methods to enumerate Escherichia coli in food were compared. They were based on AOAC methods using lauryl tryptose broth (LST) medium, LST-4-methylumbelliferyl-beta-D-glucuronide (MUG) medium, and a proposed method using regular LST in combination with E. coli (EC)-MUG medium. An efficacious and cost-effective method is needed that can detect E. coli and does not produce false presumptive positives. We tested 170 cheeses, 40 frozen processed seafood samples, 210 tree nuts, and 40 other samples. The method of choice for enumerating E. coli depends on the commodity itself. For a product, such as hard cheese or processed seafood, with a history of being negative for E. coli and other lactose-fermenting organisms, the proposed method using regular LST/EC-MUG is a good choice. These samples were seldom presumptive positive in the primary LST medium. If gas was produced, EC-MUG was an effective secondary medium. No false positives (fluorescence) or negatives were detected in EC-MUG medium. For a product with a history of being positive for E. coli and/or other lactose fermenting organisms, such as tree nutmeats or cheeses that are ripened by bacteria or mold, the method using LST-MUG is the method of choice. A presumptive positive in the LST-MUG medium was highly correlative with the biochemical tests that confirmed a sample contain E. coli. For samples spiked with E. coli, the results from each of these 3 methods were identical, and were consistent in enumerating E. coli. JF - Journal of AOAC International AU - Ekholm, D F AU - Hirshfield, I N AD - US Food and Drug Administration, Northeast Regional Laboratory, Jamaica, NY 11433, USA. PY - 2001 SP - 407 EP - 415 VL - 84 IS - 2 SN - 1060-3271, 1060-3271 KW - Culture Media KW - 0 KW - Fluorescent Dyes KW - Hymecromone KW - 3T5NG4Q468 KW - 4-methylumbelliferyl glucuronide KW - 6160-80-1 KW - Index Medicus KW - Ultraviolet Rays KW - Beverages -- microbiology KW - Freezing KW - Food Contamination KW - Seafood -- microbiology KW - Nuts -- microbiology KW - Food Preservation KW - Colony Count, Microbial -- methods KW - Food Microbiology KW - Hymecromone -- analogs & derivatives KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70799619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Rapid+methods+to+enumerate+Escherichia+coli+in+foods+using+4-methylumbelliferyl-beta-D-glucuronide.&rft.au=Ekholm%2C+D+F%3BHirshfield%2C+I+N&rft.aulast=Ekholm&rft.aufirst=D&rft.date=2001-03-01&rft.volume=84&rft.issue=2&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms of the IL-1 gene complex in coal miners with silicosis. AN - 70685304; 11241561 AB - Silicosis is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Pro-inflammatory cytokines, such as interleukin-1 (IL-1), play a key role in the development of silicosis by regulating mediators which are responsible for lung injury, inflammation, and potentially fibrosis. To study whether functional single nucleotide polymorphisms (SNPs) located in the regulatory elements of genes coding for the IL-1alpha, IL-1beta, and IL-1 receptor antagonist (RA) cytokines are associated with silicosis, we examined 318 Caucasian cases confirmed histopathologically with pulmonary silicosis and 163 controls without any apparent inflammation or other pulmonary disease. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism technique. The proportion of the IL-1RA (+ 2018) allele 2 genotype was increased in miners with silicosis (0.27) compared to controls (0.16). The odds of being a case were 2.15 (CI = 1.4-3.3) times higher for subjects with at least one copy of allele 2. No statistically significant differences in the allelic frequencies or genotype distributions for IL-1alpha (+ 4845) or IL-1beta (+ 3953) were found between the control and disease groups. This is the first report showing an association between the IL-1RA (+ 2018) polymorphism and silicosis, and suggests that this polymorphism may confer increased risk for the development of the disease. JF - American journal of industrial medicine AU - Yucesoy, B AU - Vallyathan, V AU - Landsittel, D P AU - Sharp, D S AU - Matheson, J AU - Burleson, F AU - Luster, M I AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 286 EP - 291 VL - 39 IS - 3 SN - 0271-3586, 0271-3586 KW - Interleukin-1 KW - 0 KW - Index Medicus KW - Gene Frequency KW - Aged, 80 and over KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Lung -- pathology KW - Time Factors KW - Male KW - Silicosis -- genetics KW - Silicosis -- pathology KW - Polymorphism, Genetic -- genetics KW - Interleukin-1 -- genetics KW - Coal Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70685304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Polymorphisms+of+the+IL-1+gene+complex+in+coal+miners+with+silicosis.&rft.au=Yucesoy%2C+B%3BVallyathan%2C+V%3BLandsittel%2C+D+P%3BSharp%2C+D+S%3BMatheson%2C+J%3BBurleson%2C+F%3BLuster%2C+M+I&rft.aulast=Yucesoy&rft.aufirst=B&rft.date=2001-03-01&rft.volume=39&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identifying high-risk small business industries for occupational safety and health interventions. AN - 70677549; 11241563 AB - Approximately one-third (32%) of U.S. workers are employed in small business industries (those with 80% of workers in establishments with fewer than 100 employees), and approximately 53 million persons in private industry work in small business establishments. This study was performed to identify small business industries at high risk for occupational injuries, illnesses, and fatalities. Small business industries were identified from among all three- and four-digit Standard Industrial Classification (SIC) codes and ranked using Bureau of Labor Statistics (BLS) data by rates and numbers of occupational injuries, illnesses, and fatalities. Both incidence rates and number of injury, illness, and fatality cases were evaluated. The 253 small business industries identified accounted for 1,568 work-related fatalities (34% of all private industry). Transportation incidents and violent acts were the leading causes of these fatalities. Detailed injury and illness data were available for 105 small business industries, that accounted for 1,476,400 work-related injuries, and 55,850 occupational illnesses. Many of the small business industries had morbidity and mortality rates exceeding the average rates for all private industry. The highest risk small business industries, based on a combined morbidity and mortality index, included logging, cut stone and stone products, truck terminals, and roofing, siding, and sheet metal work. Identification of high-risk small business industries indicates priorities for those interested in developing targeted prevention programs. JF - American journal of industrial medicine AU - Okun, A AU - Lentz, T J AU - Schulte, P AU - Stayner, L AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, Ohio 45226, USA. aho1@cdc.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 301 EP - 311 VL - 39 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Risk Factors KW - Humans KW - Occupational Health KW - Accidents, Occupational -- prevention & control KW - Commerce -- statistics & numerical data KW - Occupational Diseases -- prevention & control KW - Industry -- statistics & numerical data KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70677549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Identifying+high-risk+small+business+industries+for+occupational+safety+and+health+interventions.&rft.au=Okun%2C+A%3BLentz%2C+T+J%3BSchulte%2C+P%3BStayner%2C+L&rft.aulast=Okun&rft.aufirst=A&rft.date=2001-03-01&rft.volume=39&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence and risk factors of tendinitis and related disorders of the distal upper extremity among U.S. workers: comparison to carpal tunnel syndrome. AN - 70672865; 11241566 AB - National estimates of tendinitis and related disorders of the distal upper extremity among U.S. workers have not been available with the exception of carpal tunnel syndrome. The Occupational Health Supplement Data of the 1988 National Health Interview Survey were analyzed for tendinitis and related disorders of the hand/wrist and elbow (distal upper extremity) using the Survey Data Analysis (SUDAAN) software. Among the 30,074 respondents (statistically weighted population of 127 million) who had worked anytime during the previous 12 months, 0.46% (95% CI: 0.36, 0.56) reported that they experienced a "prolonged" hand discomfort which was called tendinitis, synovitis, tenosynovitis, deQuervain's disease, epicondylitis, ganglion cyst, or trigger finger, by a medical person. This corresponds to 588,000 persons (95% CI: 457,000; 712,000) reporting one of these disorders, 28% (or 164,000) of which were thought to be work-related by the medical person. Among various risk factors examined by multiple logistic regression analysis, bending/twisting of the hands/wrists at work and female gender were significantly associated with reporting of these disorders. By combining these cases with the previously reported cases of work-related carpal tunnel syndrome, we estimate that there were approximately 520,000 cases of work-related musculoskeletal disorders of the distal upper extremity among US workers in 1988. JF - American journal of industrial medicine AU - Tanaka, S AU - Petersen, M AU - Cameron, L AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Public Health Service, Cincinnati, Ohio 45226, USA. sxt16@cdc.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 328 EP - 335 VL - 39 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Sex Factors KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Arm Injuries -- epidemiology KW - Carpal Tunnel Syndrome -- epidemiology KW - Tendinopathy -- epidemiology KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70672865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Prevalence+and+risk+factors+of+tendinitis+and+related+disorders+of+the+distal+upper+extremity+among+U.S.+workers%3A+comparison+to+carpal+tunnel+syndrome.&rft.au=Tanaka%2C+S%3BPetersen%2C+M%3BCameron%2C+L&rft.aulast=Tanaka&rft.aufirst=S&rft.date=2001-03-01&rft.volume=39&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Seizure activity and hyperthermia potentiate the increases in dopamine and serotonin extracellular levels in the amygdala during exposure to d-amphetamine. AN - 70666751; 11222877 AB - Behavioral stereotypy, hyperthermia, and convulsive activity produced by exposure to multiple doses of d-amphetamine (AMPH) were related to changes in the extracellular levels of dopamine and serotonin (5-HT) in the amygdala, using the technique of microdialysis in awake and freely moving rats. Hyperactivity and stereotypy, as well as increases in microdialysis dopamine levels ranging from 100-300% of pre-AMPH basal microdialysate levels (BL), occurred during exposure to 3 doses of 2.5 mg/kg (3 x 2.5 mg/kg) AMPH. Three doses of 5 mg/kg produced a more intense stereotypic behavior as well as hyperthermia, and resulted in large increases in the peak dopamine levels (700% BL) while 5-HT levels were increased to a lesser extent (300% BL). The highest doses tested of 3 x 15 mg/kg produced convulsive activity, seizures, intense stereotypy and hyperthermia with peak microdialysate dopamine (1300% BL) and 5-HT levels (1800% BL) that were 2-fold and 6-fold greater, respectively, than those at the 3 x 5-mg/kg doses. Microdialysate glutamate levels were not changed by AMPH exposure. Rats that did not become hyperthermic when dosed with 15 mg/kg AMPH in a cold environment (10 degrees C) exhibited some hyperactivity and stereotypic behavior, but not overt convulsive behavior. Dopamine and 5-HT levels in these rats were significantly reduced by about 75% and 60%, respectively, compared to the room-temperature group. Inclusion of 2 microM tetrodotoxin (TTX) in the microdialysis buffer significantly reduced the 15-mg/kg AMPH-induced increases in dopamine by 30% and the increase in 5-HT levels by 70% at room temperature. These results indicate that a smaller portion of the dopamine release evoked by doses of AMPH that induce seizure activity is neuronal impulse-dependent while the majority of 5-HT released is impulse-dependent. Irrespective of impulse activity, the hyperthermia alone markedly potentiated dopamine release but had a lesser effect on 5-HT release. Thus, there are differences in the regulation of dopamine and serotonin release in the amygdala from high doses of AMPH, which are known to produce neurotoxicity. Further studies are necessary to determine the impact of these differences in release on AMPH neurotoxicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Tor-Agbidye, J AU - Yamamoto, B AU - Bowyer, J F AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 103 EP - 111 VL - 60 IS - 1 SN - 1096-6080, 1096-6080 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Serotonin KW - 333DO1RDJY KW - Glutamic Acid KW - 3KX376GY7L KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Amphetamine KW - CK833KGX7E KW - Dextroamphetamine KW - TZ47U051FI KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Glutamic Acid -- metabolism KW - Hydroxyindoleacetic Acid -- metabolism KW - Cold Temperature KW - Homovanillic Acid -- metabolism KW - Chromatography, High Pressure Liquid KW - Rats KW - Microdialysis KW - Behavior, Animal -- drug effects KW - Rats, Sprague-Dawley KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Behavior, Animal -- physiology KW - Male KW - Amphetamine -- metabolism KW - Seizures -- chemically induced KW - Fever -- chemically induced KW - Amygdala -- physiopathology KW - Amygdala -- metabolism KW - Dopamine -- metabolism KW - Seizures -- metabolism KW - Amygdala -- drug effects KW - Serotonin -- metabolism KW - Fever -- metabolism KW - Dextroamphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70666751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Seizure+activity+and+hyperthermia+potentiate+the+increases+in+dopamine+and+serotonin+extracellular+levels+in+the+amygdala+during+exposure+to+d-amphetamine.&rft.au=Tor-Agbidye%2C+J%3BYamamoto%2C+B%3BBowyer%2C+J+F&rft.aulast=Tor-Agbidye&rft.aufirst=J&rft.date=2001-03-01&rft.volume=60&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-10 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - The Outreach Sourcebook, Volume 7: Rural Health Demonstration Projects, 1997 to 2000. AN - 62364605; ED451002 AB - In 1997, the federal Office of Rural Health Policy awarded 3-year outreach demonstration grants to 45 projects to provide direct primary and preventive health care services to rural residents in 28 states. The grant program allows recipients to test innovative ideas against the challenges of rural health care delivery, such as provider shortages, geographic isolation, growing Hispanic/Latino populations in rural areas, and changing health care funding and delivery systems. Recipients must form a consortium of local and state agencies or institutions to work together toward project goals. All the projects in this funding cycle succeeded in their efforts, but the populations served and the models implemented were extremely diverse. Twenty-two projects focused on the specific needs of infants, children, or adolescents. Among other populations, women were served specifically by 7 projects, minority groups (Hispanics, African Americans, or Native Americans) by 16 projects, and the elderly by 9 projects. Thirteen projects focused their activities in rural schools or used schools as delivery sites. Ten projects provided continuing education opportunities to health professionals or social workers. Health education, health promotion, or disease prevention were the focus of 31 projects, with topics such as substance abuse, smoking prevention, mental health, nutrition, diabetes, and sexuality. Descriptions of the 45 projects include population served, services offered, innovative features, results, potential for replication, plans for continued funding, and contact information. (Contains title and subject indexes, a glossary, and a project locator map.) (SV) Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 143 PB - Full text at Web site: http://ftp, hrsagov/ftp/ruralhealth/vol7Sourcebookpdf KW - ERIC, Resources in Education (RIE) KW - Program Descriptions KW - Health Programs KW - Outreach Programs KW - Consortia KW - Federal Aid KW - Health Education KW - Rural Areas KW - Professional Continuing Education KW - Medical Education KW - Health Promotion KW - School Health Services KW - Health Services KW - Demonstration Programs KW - Access to Health Care KW - Community Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62364605?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Aldrin and dieldrin; a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States AN - 52210290; 2001-055053 AB - In the last decade four international agreements have focused on a group of chemical substances known as persistent organic pollutants (POPs). Global agreement on the reduction and eventual elimination of these substances by banning their production and trade is a long-term goal. Negotiations for these agreements have focused on the need to correlate data from scientists working on soil and water sampling and air pollution monitoring. Toxicologists and epidemiologists have focused on wildlife and human health effects and understanding patterns of disease requires better access to these data. In the last 20 years, substantial databases have been created and now are becoming available on the Internet. This review is a detailed examination of 2 of the 12 POPs, aldrin and dieldrin, and how scientific groups identify and measure their effects. It draws on research findings from a variety of environmental monitoring networks in the United States. An overview of the ecologic and health effects of aldrin and dieldrin provides examples of how to streamline some of the programs and improve access to mutually useful scientific data. The research groups are located in many government departments, universities, and private organizations. Identifying databases can provide an "information accelerator" useful to a larger audience and can help build better plant and animal research models across scientific fields. JF - Environmental Health Perspectives. Supplements AU - Jorgenson, J Lisa Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 113 EP - 139 PB - U. S. Department of Health & Human Services, Public Health Service, National Institutes of Health, National Institute of Environmental Health Sciences, Washington, DC VL - 109 IS - 1 SN - 1078-0475, 1078-0475 KW - United States KW - chlorinated hydrocarbons KW - water quality KW - organochlorine pesticides KW - production KW - human ecology KW - bioaccumulation KW - toxicity KW - transport KW - agrochemicals KW - halogenated hydrocarbons KW - industry KW - dieldrin KW - soils KW - insecticides KW - concentration KW - toxic materials KW - pollutants KW - global KW - pollution KW - epidemiology KW - aldrin KW - organic compounds KW - regional KW - air KW - pesticides KW - public health KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52210290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives.+Supplements&rft.atitle=Aldrin+and+dieldrin%3B+a+review+of+research+on+their+production%2C+environmental+deposition+and+fate%2C+bioaccumulation%2C+toxicology%2C+and+epidemiology+in+the+United+States&rft.au=Jorgenson%2C+J+Lisa&rft.aulast=Jorgenson&rft.aufirst=J&rft.date=2001-03-01&rft.volume=109&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives.+Supplements&rft.issn=10780475&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 183 N1 - PubXState - DC N1 - Document feature - illus. incl. 8 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - agrochemicals; air; aldrin; bioaccumulation; chlorinated hydrocarbons; concentration; dieldrin; epidemiology; global; halogenated hydrocarbons; human ecology; industry; insecticides; organic compounds; organochlorine pesticides; pesticides; pollutants; pollution; production; public health; regional; soils; toxic materials; toxicity; transport; United States; water quality ER - TY - JOUR T1 - Climate change and mosquito-borne disease. AN - 21256696; 11702247 AB - Global atmospheric temperatures are presently in a warming phase that began 250--300 years ago. Speculations on the potential impact of continued warming on human health often focus on mosquito-borne diseases. Elementary models suggest that higher global temperatures will enhance their transmission rates and extend their geographic ranges. However, the histories of three such diseases--malaria, yellow fever, and dengue--reveal that climate has rarely been the principal determinant of their prevalence or range; human activities and their impact on local ecology have generally been much more significant. It is therefore inappropriate to use climate-based models to predict future prevalence. JF - Environmental Health Perspectives AU - Reiter, P AD - Dengue Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, San Juan, Puerto Rico 00920-3860., preiter@cdc.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 141 EP - 161 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 109 IS - Suppl 1 SN - 0091-6765, 0091-6765 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Entomology Abstracts; Pollution Abstracts; Environment Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Historical account KW - Human diseases KW - Climatic changes KW - Climate change KW - Man-induced effects KW - Models KW - Public health KW - Disease transmission KW - Ecology KW - History KW - Yellow fever KW - Diseases KW - Aquatic insects KW - Temperature effects KW - Climates KW - Temperature KW - Culicidae KW - Atmospheric temperature KW - Ecosystem disturbance KW - Model Studies KW - Human factors KW - Z 05300:General KW - V 22410:Animal Diseases KW - P 0000:AIR POLLUTION KW - SW 0540:Properties of water KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21256696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Climate+change+and+mosquito-borne+disease.&rft.au=Reiter%2C+P&rft.aulast=Reiter&rft.aufirst=P&rft.date=2001-03-01&rft.volume=109&rft.issue=Suppl+1&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Human diseases; Climate change; Man-induced effects; Aquatic insects; Ecosystem disturbance; Disease transmission; Public health; Temperature effects; Yellow fever; Climatic changes; Models; Ecology; Historical account; Temperature; Atmospheric temperature; Human factors; History; Climates; Diseases; Model Studies; Culicidae ER - TY - JOUR T1 - Carcinogenic effects of polychlorinated biphenyls AN - 18583944; 5426345 AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of an important section of the Toxicological profile for polychlorinated biphenyls [ATSDR. 2000: Toxicological profile for polychlorinated biphenyls. Atlanta, GA: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry.] into the scientific literature. This article focuses on the carcinogenic effects of this group of synthetic organic chemicals (polychlorinated biphenyls) in humans and animals. Information on other health effects, toxicokinetics, mechanisms of toxicity, biomarkers, interactions, chemical and physical properties, potential for human exposure, and regulations and advisories is detailed in the profile. JF - Toxicology and Industrial Health AU - Faroon, OM AU - Keith, S AU - Jones, D AU - De Rosa, C AD - Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA, oxs0@cdc.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 41 EP - 62 VL - 17 IS - 2 SN - 0748-2337, 0748-2337 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts; Water Resources Abstracts KW - Polychlorinated Biphenyls KW - CERCLA KW - Carcinogens KW - Toxicity KW - Public health KW - USA KW - Public Health KW - Carcinogenicity KW - Water Pollution Effects KW - PCB compounds KW - PCB KW - X 24155:Biochemistry KW - H 14000:Toxicology KW - SW 3030:Effects of pollution KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18583944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Carcinogenic+effects+of+polychlorinated+biphenyls&rft.au=Faroon%2C+OM%3BKeith%2C+S%3BJones%2C+D%3BDe+Rosa%2C+C&rft.aulast=Faroon&rft.aufirst=OM&rft.date=2001-03-01&rft.volume=17&rft.issue=2&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Carcinogenicity; Toxicity; PCB; Public health; CERCLA; PCB compounds; Public Health; Water Pollution Effects; Polychlorinated Biphenyls; Carcinogens; USA ER - TY - JOUR T1 - Induction of group 17 specific antibodies by pneumococcal type 17F and 17A polysaccharide vaccines AN - 17917498; 5158313 AB - Pneumococcal capsular polysaccharide group 17 contains two distinct serotypes, 17F and 17A. Pneumococcal group 17 is present in the licensed 23 valent polysaccharide vaccines. One such vaccine contains type 17A, while the other vaccine contains type 17F. The purpose of these studies was to determine the extent of cross-protection that could be expected, as both type 17F and 17A cause disease. The antibody responses of one group of adults to a vaccine containing type 17F was compared to that of another group that received a type 17A containing vaccine. By ELISA the 17A vaccine induced more cross-reactive antibodies. Opsonophagocytic antibodies are a good predictor of protection and both vaccines induced antibodies opsonic for both 17F and 17A. We conclude that either 17F or 17A will provide similar protection against group 17 disease. JF - Biologicals AU - Frasch, CE AU - Concepcion, N F AD - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, MD, U.S.A., frasch@cber.fda.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 11 EP - 16 PB - Academic Press VL - 29 IS - 1 SN - 1045-1056, 1045-1056 KW - man KW - Streptococcus pneumoniae KW - polysaccharides KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Capsules KW - Enzyme-linked immunosorbent assay KW - Antibody response KW - Polysaccharides KW - Antibodies KW - Vaccines KW - Immune response (humoral) KW - Pneumonia KW - W3 33365:Vaccines (other) KW - J 02834:Vaccination and immunization KW - A 01099:Bacteria and fungi KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17917498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Induction+of+group+17+specific+antibodies+by+pneumococcal+type+17F+and+17A+polysaccharide+vaccines&rft.au=Frasch%2C+CE%3BConcepcion%2C+N+F&rft.aulast=Frasch&rft.aufirst=CE&rft.date=2001-03-01&rft.volume=29&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/10.1006%2Fbiol.2001.0272 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Capsules; Polysaccharides; Antibody response; Pneumonia; Immune response (humoral); Vaccines; Antibodies; Enzyme-linked immunosorbent assay DO - http://dx.doi.org/10.1006/biol.2001.0272 ER - TY - JOUR T1 - Quantitative exposure assessment: application of physiologically-based pharmacokinetic (PBPK) modeling of low-dose, long-term exposures of organic acid toxicant in the brain AN - 17916606; 5161270 AB - Our objective was to construct a physiologically-based pharmacokinetic (PBPK) model describing the kinetic behavior of 2,4-dichlorophenoxyacetic acid (2,4-D) on rats after long-term exposures to low doses. Our study demonstrated the model's ability to simulate uptake of 2,4-D in discrete areas of the rat brain. The model was derived from the generic PBPK model that was first developed for high-dose, single exposures of 2,4-D to rats or rabbits (Kim, C.S., Gargas, M.L., Andersen, M.E., 1994. Pharmacokinetic modeling of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats and rabbits brain following single dose administration. Toxicol. Lett. 74, 189-201; Kim, C.S., Slikker, W., Jr., Binienda, Z., Gargas, M.L., Andersen, M.E., 1995. Development of a physiologically based pharmacokinetic (PBPK) model for 2,4-dichlorophenoxyacetic acid (2,4-D) dosimetry in discrete areas of the brain following a single intraperitoneal or intravenous dose. Neurotox. Teratol. 17, 111-120.), to which a subcutaneous (hypodermal) compartment was incorporated for low-dose, long-term infusion. It consisted of two body compartments, along with compartments for venous and arterial blood, cerebrospinal fluid, brain plasma and six brain regions. Uptake of the toxin was membrane-limited by the blood-brain barrier with clearance from the brain provided by cerebrospinal fluid `sink' mechanisms. This model predicted profiles of 2,4-D levels in brain and blood over a 28-day period that compared well with concentrations measured in vivo with rats that had been given 2,4-D (1 or 10 mg/kg per day) with [ super(14)C]-2,4-D subcutaneously (s.c.) for 7, 14, or 28 days, respectively. This PBPK model should be an effective tool for evaluating the target tissue doses that may produce the neurotoxicity of organic acid toxicants after low-dose, long-term exposures to contaminated foods or the environment. JF - Environmental Toxicology and Pharmacology AU - Kim, C S AU - Sandberg, JA AU - Slikker, W Jr AU - Binienda, Z AU - Schlosser, P M AU - Patterson, T A AD - Food and Drug Administration, Division of Toxicological Research (HFS-506), Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 153 EP - 160 VL - 9 IS - 4 SN - 1382-6689, 1382-6689 KW - pharmacokinetics KW - rats KW - chronic exposure KW - 2,4-Dichlorophenoxyacetic aid KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - 2,4-D KW - Neurotoxicity KW - Brain KW - Models KW - N3 11104:Mammals (except primates) KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17916606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Quantitative+exposure+assessment%3A+application+of+physiologically-based+pharmacokinetic+%28PBPK%29+modeling+of+low-dose%2C+long-term+exposures+of+organic+acid+toxicant+in+the+brain&rft.au=Kim%2C+C+S%3BSandberg%2C+JA%3BSlikker%2C+W+Jr%3BBinienda%2C+Z%3BSchlosser%2C+P+M%3BPatterson%2C+T+A&rft.aulast=Kim&rft.aufirst=C&rft.date=2001-03-01&rft.volume=9&rft.issue=4&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Models; 2,4-D; Brain; Neurotoxicity ER - TY - JOUR T1 - A Cohort Study of Health Care Workers to Assess Nosocomial Transmissibility of Nipah Virus, Malaysia, 1999 AN - 17903866; 5149680 AB - During 1998-1999, an outbreak of Nipah virus encephalitis occurred in Malaysia. To assess the possibility of nosocomial transmission, 338 health care workers (HCWs) exposed and 288 HCWs unexposed to outbreak-related patients were surveyed, and their serum samples were tested for anti-Nipah virus antibody. Needlestick injuries were reported by 12 (3%) HCWs, mucosal surface exposure to body fluids by 39 (11%), and skin exposure to body fluids by 89 (25%). No encephalitis occurred in either group. Three exposed and no unexposed HCWs tested positive by EIA for IgG antibodies. It is likely that these 3 were false positives; no IgM response occurred, and the serum samples were negative for anti-Nipah virus neutralizing antibodies. The risk of nosocomial transmission of Nipah virus appears to be low; however, given the high case-fatality rate and the presence of virus in respiratory secretions and urine of some patients, standard and droplet infection-control practices should be maintained with these patients. JF - Journal of Infectious Diseases AU - Mounts, A W AU - Kaur, H AU - Parashar, U D AU - Ksiazek, T G AU - Cannon, D AU - Arokiasamy, J T AU - Anderson, L J AU - Lye AD - Respiratory and Enteric Viruses Branch and Disease Assessment and Diagnostic Sections, Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, and Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 810 EP - 813 VL - 183 IS - 5 SN - 0022-1899, 0022-1899 KW - health care workers KW - Malaysia KW - Nipah virus KW - needles KW - syringes KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Needles KW - Syringes KW - Occupational exposure KW - Medical personnel KW - V 22123:Epidemiology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17903866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Cohort+Study+of+Health+Care+Workers+to+Assess+Nosocomial+Transmissibility+of+Nipah+Virus%2C+Malaysia%2C+1999&rft.au=Mounts%2C+A+W%3BKaur%2C+H%3BParashar%2C+U+D%3BKsiazek%2C+T+G%3BCannon%2C+D%3BArokiasamy%2C+J+T%3BAnderson%2C+L+J%3BLye&rft.aulast=Mounts&rft.aufirst=A&rft.date=2001-03-01&rft.volume=183&rft.issue=5&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nipah virus; Medical personnel; Occupational exposure; Syringes; Needles ER - TY - JOUR T1 - Phylogenetic Evidence for Horizontal Transfer of mutS Alleles among Naturally Occurring Escherichia coli Strains AN - 17825646; 4860002 AB - mutS mutators accelerate the bacterial mutation rate 100- to 1, 000-fold and relax the barriers that normally restrict homeologous recombination. These mutators thus afford the opportunity for horizontal exchange of DNA between disparate strains. While much is known regarding the mutS phenotype, the evolutionary structure of the mutS super(+) gene in Escherichia coli remains unclear. The physical proximity of mutS to an adjacent polymorphic region of the chromosome suggests that this gene itself may be subject to horizontal transfer and recombination events. To test this notion, a phylogenetic approach was employed that compared gene phylogeny to strain phylogeny, making it possible to identify E. coli strains in which mutS alleles have recombined. Comparison of mutS phylogeny against predicted E. coli "whole-chromosome" phylogenies (derived from multilocus enzyme electrophoresis and mdh sequences) revealed striking levels of phylogenetic discordance among mutS alleles and their respective strains. We interpret these incongruences as signatures of horizontal exchange among mutS alleles. Examination of additional sites surrounding mutS also revealed incongruous distributions compared to E. coli strain phylogeny. This suggests that other regional sequences are equally subject to horizontal transfer, supporting the hypothesis that the 61.5-min mutS-rpoS region is a recombinational hot spot within the E. coli chromosome. Furthermore, these data are consistent with a mechanism for stabilizing adaptive changes promoted by mutS mutators through rescue of defective mutS alleles with wild-type sequences. JF - Journal of Bacteriology AU - Brown, E W AU - LeClerc, JE AU - Li, B AU - Payne, W L AU - Cebula, T A AD - Division of Molecular Biology Research and Evaluation (HFS-235), Center for Food Safety & Applied Nutrition, US Food & Drug Administration, 200 C Street SW, Washington, DC 20204, tcebula@cfsan.fda.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 1631 EP - 1644 VL - 183 IS - 5 SN - 0021-9193, 0021-9193 KW - mutS gene KW - rpoS gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Chromosomes KW - Escherichia coli KW - Horizontal transfer KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17825646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Phylogenetic+Evidence+for+Horizontal+Transfer+of+mutS+Alleles+among+Naturally+Occurring+Escherichia+coli+Strains&rft.au=Brown%2C+E+W%3BLeClerc%2C+JE%3BLi%2C+B%3BPayne%2C+W+L%3BCebula%2C+T+A&rft.aulast=Brown&rft.aufirst=E&rft.date=2001-03-01&rft.volume=183&rft.issue=5&rft.spage=1631&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.183.5.1631-1644.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Phylogeny; Horizontal transfer; Chromosomes DO - http://dx.doi.org/10.1128/JB.183.5.1631-1644.2001 ER - TY - JOUR T1 - Analytical chromatography for recovery of small amounts of staphylococcal enterotoxins from food AN - 17846564; 4877069 AB - Sample preparation is an important element in the detection of toxins in food samples. In this work, a simple analytical sample preparation method for recovery of small amount of staphylococcal enterotoxin B (SEB) and staphylococcal enterotoxin A (SEA) in food samples was developed. Cation exchanger carboxymethylcellulose (CM) was used for small-scale batch chromatography isolation of SEB from infant formula and from mushrooms spiked with SEB. The resulting materials were analyzed for SEB by Western immunoblotting. Nearly all of the extraneous substances in the sample were removed by this procedure with no significant loss of the toxin. Using this method, even small amounts of SE (0.75 ng/g) can be recovered and immunologically analyzed by Western blotting or by ELISA with a very low background. Because this method is effective, rapid, simple and inexpensive, it has the potential to be a general method for the preparation of samples used for analysis of SEs. JF - International Journal of Food Microbiology AU - Balaban, N AU - Rasooly, A AD - Division of Microbiological Studies, US Food and Drug Administration, 200 C St. SW, Washington, DC 20204, USA, axr@vm.cfsan.fda.gov Y1 - 2001/02/28/ PY - 2001 DA - 2001 Feb 28 SP - 33 EP - 40 VL - 64 IS - 1-2 SN - 0168-1605, 0168-1605 KW - enterotoxin A KW - enterotoxin B KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Chromatography KW - Staphylococcus KW - Enterotoxins KW - Food spoilage KW - Toxins KW - A 01116:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17846564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Analytical+chromatography+for+recovery+of+small+amounts+of+staphylococcal+enterotoxins+from+food&rft.au=Balaban%2C+N%3BRasooly%2C+A&rft.aulast=Balaban&rft.aufirst=N&rft.date=2001-02-28&rft.volume=64&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus; Toxins; Enterotoxins; Food spoilage; Chromatography ER - TY - JOUR T1 - Mortality in antiepileptic drug development programs. AN - 70662191; 11222797 AB - Pooled data from New Drug Applications (NDAs) submitted to the U.S. Food and Drug Administration (FDA) provide an opportunity to study the incidence of and risk factors for rare events. To examine the incidence and causes of mortality in patients with epilepsy participating in clinical trials of antiepileptic drugs (AEDs); and to examine the incidence of and risk factors for sudden unexplained death in such patients. Exposure data and death narratives were obtained from the NDAs of five recently reviewed AEDs. Deaths were classified as sudden unexplained, accidental, or other cause using the 1993 Burroughs-Wellcome expert panel criteria, and mortality rates were calculated for each category. Add-on trials were analyzed separately from monotherapy initiation trials. Among 9,144 patients in the add-on trial database, the all-cause and sudden unexplained mortality rates were 9.1 and 3.8 deaths per 1,000 person-years (124 and 52 deaths in 13,617.1 person-years of drug exposure). Sixty-five percent of all deaths were related to the underlying epilepsy. Of the examined risk factors, only age was associated with the incidence of sudden unexplained death. Among 1,293 patients in the monotherapy initiation trials, the all-cause and sudden unexplained mortality rates were 7.1 and 0 deaths per 1,000 person-years (7 and 0 deaths in 982.5 person-years of drug exposure). A large proportion of the deaths in the add-on cohort was attributable to epilepsy-related causes. Mortality due to sudden death in the add-on cohort falls into the high end of the reported range for patients with epilepsy. The difference in mortality due to sudden death between the add-on and monotherapy initiation cohorts suggests that disease severity is the primary determining factor for risk of sudden unexplained death. JF - Neurology AU - Racoosin, J A AU - Feeney, J AU - Burkhart, G AU - Boehm, G AD - Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD 20857, USA. racoosinj@cder.fda.gov Y1 - 2001/02/27/ PY - 2001 DA - 2001 Feb 27 SP - 514 EP - 519 VL - 56 IS - 4 SN - 0028-3878, 0028-3878 KW - Anticonvulsants KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Cause of Death KW - Child, Preschool KW - Drug Industry KW - Clinical Trials as Topic KW - Anticonvulsants -- adverse effects KW - Epilepsy -- drug therapy KW - Epilepsy -- mortality KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70662191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Mortality+in+antiepileptic+drug+development+programs.&rft.au=Racoosin%2C+J+A%3BFeeney%2C+J%3BBurkhart%2C+G%3BBoehm%2C+G&rft.aulast=Racoosin&rft.aufirst=J&rft.date=2001-02-27&rft.volume=56&rft.issue=4&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Particulate penetration characteristics of porus foam at high face velocities AN - 39415586; 3578821 AU - Vinson, R P AU - Volkwein, J C Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39415586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Particulate+penetration+characteristics+of+porus+foam+at+high+face+velocities&rft.au=Vinson%2C+R+P%3BVolkwein%2C+J+C&rft.aulast=Vinson&rft.aufirst=R&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Poster Paper No. 11PD1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Large-particle size distribution analyzer AN - 39415493; 3578800 AU - Baron, P A AU - Martinez, AB Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39415493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Large-particle+size+distribution+analyzer&rft.au=Baron%2C+P+A%3BMartinez%2C+AB&rft.aulast=Baron&rft.aufirst=P&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Poster Paper No. 11PA4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modelling of transition phase filter loading with liquid aerosols AN - 39341473; 3578659 AU - Earnest, G S AU - Chen, D-R AU - Pui, DYH Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modelling+of+transition+phase+filter+loading+with+liquid+aerosols&rft.au=Earnest%2C+G+S%3BChen%2C+D-R%3BPui%2C+DYH&rft.aulast=Earnest&rft.aufirst=G&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Poster Paper No. 4PK3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of petroleum asphalt aerosol in a laboratory generation system AN - 39334621; 3578798 AU - Tomblyn, S AU - Jones, W G AU - Goldsmith, W T AU - Stone, S AU - Afshari, A AU - Frazer, D Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39334621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+petroleum+asphalt+aerosol+in+a+laboratory+generation+system&rft.au=Tomblyn%2C+S%3BJones%2C+W+G%3BGoldsmith%2C+W+T%3BStone%2C+S%3BAfshari%2C+A%3BFrazer%2C+D&rft.aulast=Tomblyn&rft.aufirst=S&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Poster Paper No. 11PA2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asphalt inhalation exposure system with feedback control AN - 39333275; 3578799 AU - Goldsmith, W T AU - Stone, S AU - Afshari, A AU - Tomblyn, S AU - Reynolds, J S AU - Frazer, D Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Asphalt+inhalation+exposure+system+with+feedback+control&rft.au=Goldsmith%2C+W+T%3BStone%2C+S%3BAfshari%2C+A%3BTomblyn%2C+S%3BReynolds%2C+J+S%3BFrazer%2C+D&rft.aulast=Goldsmith&rft.aufirst=W&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Poster Paper No. 11PA3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the aerosols resulting from arc welding processes AN - 39333083; 3578731 AU - Zimmer, A T AU - Biswas, P Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+the+aerosols+resulting+from+arc+welding+processes&rft.au=Zimmer%2C+A+T%3BBiswas%2C+P&rft.aulast=Zimmer&rft.aufirst=A&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Paper No. 7C3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uptake of chemicals into the egg: Veterinary drugs and pesticides AN - 39315451; 3577047 AU - Donoughue, D Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39315451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Uptake+of+chemicals+into+the+egg%3A+Veterinary+drugs+and+pesticides&rft.au=Donoughue%2C+D&rft.aulast=Donoughue&rft.aufirst=D&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: World's Poultry Science Association, 759 Victoria Square, Suite 300, Montreal, Quebec H2Y 2J7, Canada N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respirable size mass loss in conductive silicone rubber tubing AN - 39282106; 3578760 AU - Volkwein, J C AU - Vinson, R P AU - Tuchman, D AU - Timko, R J Y1 - 2001/02/26/ PY - 2001 DA - 2001 Feb 26 KW - CPI, Conference Papers Index KW - U 1200:Aquatic Science KW - U 7000:Multidisciplinary KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39282106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Respirable+size+mass+loss+in+conductive+silicone+rubber+tubing&rft.au=Volkwein%2C+J+C%3BVinson%2C+R+P%3BTuchman%2C+D%3BTimko%2C+R+J&rft.aulast=Volkwein&rft.aufirst=J&rft.date=2001-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for Exposure Analysis, 1330 Kemper Meadow Drive, Cincinnati, OH 45240, USA; phone: 513-742-2227; fax: 513-742-3355; email: mail@aaar.org; URL: http://isam.org. Paper No. 9A3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory perspective on clinical trial simulation AN - 39322124; 3553729 AU - Gobburu, J Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39322124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulatory+perspective+on+clinical+trial+simulation&rft.au=Gobburu%2C+J&rft.aulast=Gobburu&rft.aufirst=J&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CYP450 drug interaction: Clinical implication - An FDA perspective AN - 39309695; 3553794 AU - Honig, P Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39309695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=CYP450+drug+interaction%3A+Clinical+implication+-+An+FDA+perspective&rft.au=Honig%2C+P&rft.aulast=Honig&rft.aufirst=P&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory perspectives on methods validation AN - 39308534; 3558580 AU - Rajagopalan, R Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39308534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulatory+perspectives+on+methods+validation&rft.au=Rajagopalan%2C+R&rft.aulast=Rajagopalan&rft.aufirst=R&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transfusable proteins made in plants AN - 39307243; 3557112 AU - Stein, KE Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39307243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transfusable+proteins+made+in+plants&rft.au=Stein%2C+KE&rft.aulast=Stein&rft.aufirst=KE&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The American Society of Hematology, 1900 M Street, NW, Suite 200, Washington, DC 20036, USA; phone: 202 776 0544; fax: 202 776 0545; email: ASH@hematology.org; URL: www.hematology.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stromal activin A inhibits plasma cell tumor development: Relevance to multiple myeloma AN - 39305729; 3556754 AU - Shoham, T AU - Barda-Saad, M AU - Zipori, D Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39305729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stromal+activin+A+inhibits+plasma+cell+tumor+development%3A+Relevance+to+multiple+myeloma&rft.au=Shoham%2C+T%3BBarda-Saad%2C+M%3BZipori%2C+D&rft.aulast=Shoham&rft.aufirst=T&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: New York Medical College, Valhalla, New York 10595, USA; URL: www.nymc.edu N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of pharmacokinetic/biopharmaceutic principles to advance veterinary medicine in the new millenium AN - 39298924; 3553775 AU - Martinez, M Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39298924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+pharmacokinetic%2Fbiopharmaceutic+principles+to+advance+veterinary+medicine+in+the+new+millenium&rft.au=Martinez%2C+M&rft.aulast=Martinez&rft.aufirst=M&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishing comparability for biological products AN - 39290953; 3553730 AU - Green, D Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Establishing+comparability+for+biological+products&rft.au=Green%2C+D&rft.aulast=Green&rft.aufirst=D&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent trends in pharmaceutical aqueous polymeric coating systems, regulatory perspectives AN - 39289079; 3553782 AU - Mitra, A K Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39289079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Recent+trends+in+pharmaceutical+aqueous+polymeric+coating+systems%2C+regulatory+perspectives&rft.au=Mitra%2C+A+K&rft.aulast=Mitra&rft.aufirst=A&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro BA/BE assessment: Future directions and challenges AN - 39284268; 3553648 AU - Hussain, A S Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39284268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+BA%2FBE+assessment%3A+Future+directions+and+challenges&rft.au=Hussain%2C+A+S&rft.aulast=Hussain&rft.aufirst=A&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drug metabolism: Different pathways involved AN - 39284205; 3553755 AU - Viswanathan, C T Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39284205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Drug+metabolism%3A+Different+pathways+involved&rft.au=Viswanathan%2C+C+T&rft.aulast=Viswanathan&rft.aufirst=C&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filing of IND/NDA AN - 39238748; 3553665 AU - Viswanathan, C T Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39238748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Filing+of+IND%2FNDA&rft.au=Viswanathan%2C+C+T&rft.aulast=Viswanathan&rft.aufirst=C&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulating prescription drug promotion on the Internet AN - 39236910; 3553687 AU - Moncavage, M Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39236910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulating+prescription+drug+promotion+on+the+Internet&rft.au=Moncavage%2C+M&rft.aulast=Moncavage&rft.aufirst=M&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic ultrasound: New strategy of apoptosis induction in malignant hemopoietic cells AN - 39235705; 3556752 AU - Ashush, H AU - Firestein, F AU - Elimelech, R AU - Barda-Saad, M AU - Radnay, J AU - Shemesh, L AU - Rosenchein, U AU - Rozenszajn, LA Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39235705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Therapeutic+ultrasound%3A+New+strategy+of+apoptosis+induction+in+malignant+hemopoietic+cells&rft.au=Ashush%2C+H%3BFirestein%2C+F%3BElimelech%2C+R%3BBarda-Saad%2C+M%3BRadnay%2C+J%3BShemesh%2C+L%3BRosenchein%2C+U%3BRozenszajn%2C+LA&rft.aulast=Ashush&rft.aufirst=H&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: New York Medical College, Valhalla, New York 10595, USA; URL: www.nymc.edu N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptosis induction in human p53 positive cancer cells treated with therapeutic ultrasound AN - 39232162; 3556807 AU - Shemesh, L AU - Ashush, H AU - Firstein, F AU - Barda-Saad, M AU - Rosenschein, U AU - Rozenszajn, LA Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39232162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Apoptosis+induction+in+human+p53+positive+cancer+cells+treated+with+therapeutic+ultrasound&rft.au=Shemesh%2C+L%3BAshush%2C+H%3BFirstein%2C+F%3BBarda-Saad%2C+M%3BRosenschein%2C+U%3BRozenszajn%2C+LA&rft.aulast=Shemesh&rft.aufirst=L&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: New York Medical College, Valhalla, New York 10595, USA; URL: www.nymc.edu. Paper No. 98 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physiologic and functional changes due to hepatic injury AN - 39230045; 3553691 AU - Senior, J Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39230045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Physiologic+and+functional+changes+due+to+hepatic+injury&rft.au=Senior%2C+J&rft.aulast=Senior&rft.aufirst=J&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discussion of compliance considerations when using novel techniques to assess the adequacy of mix AN - 39229062; 3553799 AU - Buhay, N Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39229062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Discussion+of+compliance+considerations+when+using+novel+techniques+to+assess+the+adequacy+of+mix&rft.au=Buhay%2C+N&rft.aulast=Buhay&rft.aufirst=N&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dermatopharmacokinetic approach for bioequivalence assessment of topical drug products AN - 39229036; 3553787 AU - Shah, V P Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39229036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dermatopharmacokinetic+approach+for+bioequivalence+assessment+of+topical+drug+products&rft.au=Shah%2C+V+P&rft.aulast=Shah&rft.aufirst=V&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sterility assurance issues with lipid-based and disperse systems AN - 39210943; 3553676 AU - Levchuk, J W Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sterility+assurance+issues+with+lipid-based+and+disperse+systems&rft.au=Levchuk%2C+J+W&rft.aulast=Levchuk&rft.aufirst=J&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism as the principal confounding factor for first-in-human trials AN - 39210914; 3553662 AU - Collins, J M Y1 - 2001/02/22/ PY - 2001 DA - 2001 Feb 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metabolism+as+the+principal+confounding+factor+for+first-in-human+trials&rft.au=Collins%2C+J+M&rft.aulast=Collins&rft.aufirst=J&rft.date=2001-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Pharmaceutical Scientists, 2107 Wilson Blvd., Suite 700, Arlington, Virginia, 22201, USA; phone: 703-243-2800; fax: 703-243-9650; email: aaps@aaps.org; URL: www.aaps.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Rapid Detection and Identification of Bacterial Strains By Fourier Transform Near-Infrared Spectroscopy AN - 18410570; 5395039 AB - The use of Fourier transform near-infrared (FT-NIR) spectroscopy and multivariate pattern recognition techniques for the rapid detection and identification of bacterial contamination in liquids was evaluated. The complex biochemical composition of bacteria yields FT-NIR vibrational transitions (overtone and combination bands) that can be used for classification and identification. Bacterial suspensions (Escherichia coli HB101, E. coli ATCC 43888, E. coli 1224, Bacillus amyloliquifaciens, Pseudomonas aeruginosa, Bacillus cereus, and Listeria innocua) were filtered to harvest the cells and eliminate the matrix, which has a strong NIR signal. FT-NIR measurements were done using a diffuse reflection-integrating sphere. Principal component analysis showed tight clustering of the bacterial strains at the information-rich spectral region of 6000-4000 cm super(-1). The method reproducibly distinguished between different E. coli isolates and conclusively identified the relationship between a new isolate and one of the test species. This methodology may allow for the rapid assessment of potential bacterial contamination in liquids with minimal sample preparation. JF - Journal of Agricultural and Food Chemistry AU - Rodriguez-Saona, LE AU - Khambaty, F M AU - Fry, F S AU - Calvey, E M AD - U.S. Food and Drug Administration, 200 C Street S.W., Washington, D.C. 20204, USA, ecalvey@cfsan.fda.gov Y1 - 2001/02/19/ PY - 2001 DA - 2001 Feb 19 SP - 574 EP - 579 VL - 49 IS - 2 SN - 0021-8561, 0021-8561 KW - Fourier transform near-infrared spectroscopy KW - methodology KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01116:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18410570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Rapid+Detection+and+Identification+of+Bacterial+Strains+By+Fourier+Transform+Near-Infrared+Spectroscopy&rft.au=Rodriguez-Saona%2C+LE%3BKhambaty%2C+F+M%3BFry%2C+F+S%3BCalvey%2C+E+M&rft.aulast=Rodriguez-Saona&rft.aufirst=LE&rft.date=2001-02-19&rft.volume=49&rft.issue=2&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf000776j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/jf000776j ER - TY - JOUR T1 - Correlation of blood cholinesterase levels with toxicity of sarin in rats. AN - 70586606; 11212943 AB - The dose-mortality response curve for sarin when administered to pregnant rats is extremely steep. The pregnant animal either died during the treatment or survived with no observable fetal toxicity. Animals that died displayed many symptoms characteristic of anticholinesterase toxicity. The present study was conducted to determine whether the maternal deaths, clinical observations, and/or weight loss could be correlated with baseline blood cholinesterase levels in individual animals. Cholinesterase levels (plasma and erythrocyte) were obtained prior to, during, and following treatment of nonpregnant rats by gavage with 380 microg/kg/d sarin for 10 d. After the first dose, there was a drop in the plasma cholinesterase levels, which then remained low throughout the dosing period. There was a statistically significant correlation between body weight loss and plasma cholinesterase levels of the sarin dosed animals. The surviving animals also had lower plasma cholinesterase levels and lower body weights, both of which recovered on the cessation of dosing. The erythrocyte cholinesterase levels were not different between treated and nontreated rats. Neither plasma or erythrocyte baseline cholinesterase levels nor relative or absolute cholinesterase decline values could be used as predictors of mortality from sarin administration in rats. JF - Journal of toxicology and environmental health. Part A AU - Young, J F AU - Gough, B J AU - Suber, R L AU - Gaylor, D W AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA. jyoung@nctr.fda.gov Y1 - 2001/02/09/ PY - 2001 DA - 2001 Feb 09 SP - 161 EP - 174 VL - 62 IS - 3 SN - 1528-7394, 1528-7394 KW - Cholinesterase Inhibitors KW - 0 KW - Sarin KW - B4XG72QGFM KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Rats KW - Animals KW - Erythrocytes -- enzymology KW - Blood Specimen Collection -- methods KW - Weight Loss -- drug effects KW - Tail -- blood supply KW - Cranial Sinuses KW - Female KW - Cholinesterase Inhibitors -- toxicity KW - Cholinesterases -- blood KW - Sarin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70586606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Correlation+of+blood+cholinesterase+levels+with+toxicity+of+sarin+in+rats.&rft.au=Young%2C+J+F%3BGough%2C+B+J%3BSuber%2C+R+L%3BGaylor%2C+D+W&rft.aulast=Young&rft.aufirst=J&rft.date=2001-02-09&rft.volume=62&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Current status and future trends in vaccine regulation--USA. AN - 70635308; 11166876 AB - In regulating vaccines, the US Food and Drug Administration (FDA) is governed by the Code of Federal Regulations. These regulations serve as the framework for product characterization, as well as preclinical and clinical testing strategies. Novel vaccine approaches such as combination vaccines, vectored vaccines, new adjuvants, and novel delivery systems pose unique regulatory challenges for the FDA. If US licensure is sought, communication with the FDA throughout the clinical development of a product is essential to identify and implement the appropriate strategies for demonstrating the safety and effectiveness of a new product. JF - Vaccine AU - Falk, L A AU - Ball, L K AD - Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, FDA HFM #481, 1401 Rockville Pike, Rockville, MD 20852, USA. falk@cber.fda.gov Y1 - 2001/02/08/ PY - 2001 DA - 2001 Feb 08 SP - 1567 EP - 1572 VL - 19 IS - 13-14 SN - 0264-410X, 0264-410X KW - Adjuvants, Immunologic KW - 0 KW - Vaccines KW - Vaccines, Attenuated KW - Vaccines, Combined KW - Index Medicus KW - United States KW - Genetic Vectors -- standards KW - Vaccines, Attenuated -- therapeutic use KW - Vaccines, Attenuated -- standards KW - Drug Evaluation, Preclinical -- standards KW - Vaccines, Combined -- adverse effects KW - Vaccines, Combined -- therapeutic use KW - Clinical Trials as Topic -- standards KW - Clinical Trials as Topic -- adverse effects KW - Drug Delivery Systems -- standards KW - Adjuvants, Immunologic -- standards KW - Vaccines, Combined -- standards KW - Drug Evaluation, Preclinical -- adverse effects KW - Drug Delivery Systems -- adverse effects KW - Vaccines, Attenuated -- adverse effects KW - Genetic Vectors -- adverse effects KW - Genetic Vectors -- genetics KW - Adjuvants, Immunologic -- adverse effects KW - Quality Control KW - Licensure KW - Adjuvants, Immunologic -- therapeutic use KW - Vaccines -- standards KW - Vaccines -- adverse effects KW - United States Food and Drug Administration -- trends KW - Drug Industry -- standards KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Vaccines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70635308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Current+status+and+future+trends+in+vaccine+regulation--USA.&rft.au=Falk%2C+L+A%3BBall%2C+L+K&rft.aulast=Falk&rft.aufirst=L&rft.date=2001-02-08&rft.volume=19&rft.issue=13-14&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pre-clinical methods for detecting the hypersensitivity potential of pharmaceuticals: regulatory considerations AN - 17835322; 4868566 AB - Immune-based systemic hypersensitivities account for a significant number of adverse drug reactions. There appear to be no adequate nonclinical models to predict systemic hypersensitivity to small molecular weight drugs. Although there are very good methods for detecting drugs that can induce contact sensitization, these have not been successfully adapted for prediction of systemic hypersensitivity. Several factors have made the development of adequate models difficult. The term systemic hypersensitivity encompases many discrete immunopathologies. Each type of immunopathology presumably is the result of a specific cluster of immunologic and biochemical phenomena. Certainly other factors, such as genetic predisposition, metabolic idiosyncrasies, and concomitant diseases, further complicate the problem. Therefore, it may be difficult to find common mechanisms upon which to construct adequate models to predict specific types of systemic hypersensitivity reactions. There is some reason to hope, however, that adequate methods could be developed for at least identifying drugs that have the potential to produce signs indicative of a general hazard for immune-based reactions. JF - Toxicology AU - Hastings, K L AD - Division of Special Pathogen and Immunologic Drug Products, Center for Drug Evaluation and Research, United States Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA, hastingsk@cder.fda.gov Y1 - 2001/02/02/ PY - 2001 DA - 2001 Feb 02 SP - 85 EP - 89 VL - 158 IS - 1-2 SN - 0300-483X, 0300-483X KW - prediction KW - models KW - hypersensitivity KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - Allergenicity KW - Government policy KW - Pharmaceutical industry KW - Hypersensitivity KW - Government regulations KW - Pharmaceuticals KW - Immune response KW - Drugs KW - Side effects KW - X 24230:Legislation & recommended standards KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17835322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Pre-clinical+methods+for+detecting+the+hypersensitivity+potential+of+pharmaceuticals%3A+regulatory+considerations&rft.au=Hastings%2C+K+L&rft.aulast=Hastings&rft.aufirst=K&rft.date=2001-02-02&rft.volume=158&rft.issue=1-2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Special Issue: 8th Summer School in Immunotoxicology. Preclinical Methods for Detecting the Potential Hypersensitivity of Pharmaceuticals. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drugs; Pharmaceutical industry; Government regulations; Side effects; Risk assessment; Government policy; Pharmaceuticals; Hypersensitivity; Immune response; Allergenicity ER - TY - JOUR T1 - Determination of bromethalin in commercial rodenticides found in consumer product samples by HPLC-UV-vis spectrophotometry and HPLC-negative-ion APCI-MS. AN - 76958882; 11245225 AB - A small amount of green particulate material is encountered in a consumer complaint sample. The green particulates in the sample are identified as a bromethalin-containing rodenticide using high-performance liquid chromatographic (HPLC)-UV-vis spectrophotometric and HPLC-negative-ion atmospheric pressure chemical ionization (APCI)-mass spectrometric (MS) approaches, which are commonly used for the detection and confirmation of bromethalin in grain-based rodenticides. The selective and sensitive nature of the MS detector makes it possible to determine bromethalin without extensive sample cleanup and preconcentration. The estimated detection limit with the UV-vis detector is 500 pg of bromethalin injected into the column. The extensive fragmentation of the bromethalin molecule under APCI conditions provides sufficient structural information for positive identification. JF - Journal of chromatographic science AU - Mesmer, M Z AU - Flurer, R A AD - United States Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 49 EP - 53 VL - 39 IS - 2 SN - 0021-9665, 0021-9665 KW - Aniline Compounds KW - 0 KW - Pharmaceutical Preparations KW - Rodenticides KW - bromethalin KW - GM59MTH1FS KW - Index Medicus KW - Food Analysis KW - Food Contamination KW - Pharmaceutical Preparations -- analysis KW - Rodenticides -- analysis KW - Chromatography, High Pressure Liquid -- methods KW - Mass Spectrometry -- methods KW - Aniline Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76958882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Determination+of+bromethalin+in+commercial+rodenticides+found+in+consumer+product+samples+by+HPLC-UV-vis+spectrophotometry+and+HPLC-negative-ion+APCI-MS.&rft.au=Mesmer%2C+M+Z%3BFlurer%2C+R+A&rft.aulast=Mesmer&rft.aufirst=M&rft.date=2001-02-01&rft.volume=39&rft.issue=2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New nephron development in goldfish (Carassius auratus) kidneys following repeated gentamicin-induced nephrotoxicosis. AN - 71302528; 11926303 AB - Renal development in mammalian kidneys can only be studied in embryonic animals. Hence, research in this area is hampered by the need to maintain pregnant animals and by the small size of the embryonic kidney. Here, we describe a goldfish (Carassius auratus) model for studying renal repair and nephron development in an adult animal. Previous studies have indicated that chemically induced nephrotoxicosis in goldfish is followed by new nephron development. We tested the hypothesis that new nephron development is not a one-time only event and, thus, will occur after repeated nephrotoxic events. We used repeated injections of gentamicin (50 mg/kg of body weight), a nephrotoxic antibiotic, which has been used as a model nephrotoxicant to study renal repair. Fish were allowed either a recovery period of 9 or 24 weeks between injections. In both experiments, new nephrons developed after each injection of gentamicin, supporting our hypothesis. Nephron development occurring after a 9-week recovery period was similar to development observed after a 24-week recovery period; therefore, the shorter experimental paradigm appears sufficient and can save time and money. Future research using this fish nephrogenesis model may identify the genes responsible for nephron neogenesis. Such information is a prerequisite for developing alternative renal replacement therapies based on the induction of de novo nephrogenesis in diseased kidneys. JF - Comparative medicine AU - Salice, C J AU - Rokous, J S AU - Kane, A S AU - Reimschuessel, R AD - US Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland 20708, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 56 EP - 59 VL - 51 IS - 1 SN - 1532-0820, 1532-0820 KW - Anti-Bacterial Agents KW - 0 KW - Gentamicins KW - Index Medicus KW - Models, Animal KW - Animals KW - Gentamicins -- toxicity KW - Kidney -- pathology KW - Goldfish -- growth & development KW - Nephrons -- drug effects KW - Nephrons -- growth & development KW - Kidney -- drug effects KW - Anti-Bacterial Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71302528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+medicine&rft.atitle=New+nephron+development+in+goldfish+%28Carassius+auratus%29+kidneys+following+repeated+gentamicin-induced+nephrotoxicosis.&rft.au=Salice%2C+C+J%3BRokous%2C+J+S%3BKane%2C+A+S%3BReimschuessel%2C+R&rft.aulast=Salice&rft.aufirst=C&rft.date=2001-02-01&rft.volume=51&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Comparative+medicine&rft.issn=15320820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-16 N1 - Date created - 2002-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative analysis of phospholipid peroxidation and antioxidant protection in live human epidermal keratinocytes. AN - 71104806; 11508692 AB - To characterize oxidative stress in phospholipids of normal human epidermal keratinocytes we metabolically labeled their membrane phospholipids with a natural oxidation-sensitive fluorescent fatty acid, cis-parinaric acid, and exposed the cells to two different sources of oxidants--a lipid-soluble azo-initiator of peroxyl radicals, 2,2'-azobis(2,4-dimethyl-valeronitrile), AMVN, and a superoxide generator, xanthine oxidase/xanthine. We demonstrated that both oxidants induced pronounced oxidation of four major classes of cis-parinaric acid-labeled phospholipids-phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol-in normal human epidermal keratinocytes that was not detectable as any significant change of their phospholipid composition. Vitamin E was effective in protecting the cells against phospholipid peroxidation. Since viability of normal human epidermal keratinocytes was not changed either by labeling or exposure to oxidants the labeling protocol and oxidative stress employed are compatible with the quantitative analysis of phospholipid peroxidation in viable cells. JF - Bioscience reports AU - Shvedova, A A AU - Tyurina, Y Y AU - Tyurin, V A AU - Kikuchi, Y AU - Kagan, V E AU - Quinn, P J AD - Health Effects Laboratory Division, NIOSH, Morgantown, WV 26505, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 33 EP - 43 VL - 21 IS - 1 SN - 0144-8463, 0144-8463 KW - Antioxidants KW - 0 KW - Azo Compounds KW - Fatty Acids, Unsaturated KW - Fluorescent Dyes KW - Nitriles KW - Oxidants KW - Phospholipids KW - Vitamin E KW - 1406-18-4 KW - 2,2'-azobis(2,4-dimethylvaleronitrile) KW - 4419-11-8 KW - Xanthine Oxidase KW - EC 1.17.3.2 KW - parinaric acid KW - PK8M3ENX8C KW - Index Medicus KW - Fatty Acids, Unsaturated -- pharmacokinetics KW - Nitriles -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Cells, Cultured -- drug effects KW - Chromatography, High Pressure Liquid KW - Cell Survival -- drug effects KW - Cells, Cultured -- metabolism KW - Adult KW - Xanthine Oxidase -- pharmacology KW - Vitamin E -- pharmacology KW - Azo Compounds -- pharmacology KW - Fluorescent Dyes -- pharmacokinetics KW - Cell Survival -- physiology KW - Oxidative Stress -- physiology KW - Skin -- physiopathology KW - Skin -- drug effects KW - Oxidants -- pharmacology KW - Antioxidants -- pharmacology KW - Skin -- metabolism KW - Keratinocytes -- drug effects KW - Phospholipids -- metabolism KW - Oxidative Stress -- drug effects KW - Lipid Peroxidation -- drug effects KW - Keratinocytes -- metabolism KW - Lipid Peroxidation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71104806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioscience+reports&rft.atitle=Quantitative+analysis+of+phospholipid+peroxidation+and+antioxidant+protection+in+live+human+epidermal+keratinocytes.&rft.au=Shvedova%2C+A+A%3BTyurina%2C+Y+Y%3BTyurin%2C+V+A%3BKikuchi%2C+Y%3BKagan%2C+V+E%3BQuinn%2C+P+J&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2001-02-01&rft.volume=21&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Bioscience+reports&rft.issn=01448463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-22 N1 - Date created - 2001-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype. AN - 70673236; 11241757 AB - The Tg.AC transgenic mouse carries the v-Ha-ras oncogene under the control of the zeta-globin promoter and is currently being used in a short-term carcinogenesis assay for safety testing of pharmaceuticals. A subset of hemizygous Tg.AC mice was found to be nonresponsive to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, which characteristically induces skin papillomas in these mice with repeated dermal applications. We previously showed that responder and nonresponder hemizygous Tg.AC mice carry about 40 copies of transgene but that the nonresponders had lost a 2-kb BamHI fragment containing the zeta-globin promoter sequence. The present restriction enzyme and S1 nuclease digestion experiments strongly suggested that the 2-kb BamHI fragment resulted from the orientation of two transgenes in an inverted repeat formation. Two subsets of nonresponder Tg.AC mice were identified. Restriction enzyme and S1 nuclease digestion experiments suggested that one nonresponder genotype was produced by a large deletion of one or more near complete copies of transgene sequence and the other genotype was produced by a small deletion near the apex of the "head-to-head" juncture of the inverted repeat. Polymerase chain reaction amplification, cloning, and sequencing results confirmed the palindromic orientation of transgene in Tg.AC mice. Our results indicated that, despite the presence of multiple copies of transgene in a direct repeat orientation, loss of symmetry in the palindromic array of transgene sequence results in the loss of the responder phenotype in Tg.AC mice. Mol. Carcinog. 30:99-110, 2001. Published 2001 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Honchel, R AU - Rosenzweig, B A AU - Thompson, K L AU - Blanchard, K T AU - Furst, S M AU - Stoll, R E AU - Sistare, F D AD - Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland 20708, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 99 EP - 110 VL - 30 IS - 2 SN - 0899-1987, 0899-1987 KW - Globins KW - 9004-22-2 KW - DNA KW - 9007-49-2 KW - Single-Strand Specific DNA and RNA Endonucleases KW - EC 3.1.30.1 KW - Index Medicus KW - Phenotype KW - Polymerase Chain Reaction KW - Animals KW - Base Sequence KW - Sequence Homology, Nucleic Acid KW - Blotting, Southern KW - DNA -- metabolism KW - Molecular Sequence Data KW - Mice KW - Nucleic Acid Conformation KW - Single-Strand Specific DNA and RNA Endonucleases -- metabolism KW - Gene Deletion KW - Genes, ras -- genetics KW - Globins -- genetics KW - Transgenes -- genetics KW - Repetitive Sequences, Nucleic Acid -- genetics KW - Mice, Transgenic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70673236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Loss+of+palindromic+symmetry+in+Tg.AC+mice+with+a+nonresponder+phenotype.&rft.au=Honchel%2C+R%3BRosenzweig%2C+B+A%3BThompson%2C+K+L%3BBlanchard%2C+K+T%3BFurst%2C+S+M%3BStoll%2C+R+E%3BSistare%2C+F+D&rft.aulast=Honchel&rft.aufirst=R&rft.date=2001-02-01&rft.volume=30&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stevens-Johnson syndrome and toxic epidermal necrolysis after vaccination: reports to the vaccine adverse event reporting system. AN - 70665638; 11224848 AB - We conducted a telephone survey of reports of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) to the Vaccine Adverse Event Reporting System. We identified six cases of SJS or TEN after vaccination without other obvious triggers, suggesting that SJS and TEN might very rarely be caused by vaccination. Confirmation of this hypothesis will likely require controlled studies. JF - The Pediatric infectious disease journal AU - Ball, R AU - Ball, L K AU - Wise, R P AU - Braun, M M AU - Beeler, J A AU - Salive, M E AD - The Vaers Working Group Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA. BallR@cber.fda.gov Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 219 EP - 223 VL - 20 IS - 2 SN - 0891-3668, 0891-3668 KW - Index Medicus KW - Infant KW - Telephone KW - Humans KW - Adult KW - Follow-Up Studies KW - Male KW - Female KW - Child, Preschool KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Stevens-Johnson Syndrome -- etiology KW - Vaccination -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70665638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Stevens-Johnson+syndrome+and+toxic+epidermal+necrolysis+after+vaccination%3A+reports+to+the+vaccine+adverse+event+reporting+system.&rft.au=Ball%2C+R%3BBall%2C+L+K%3BWise%2C+R+P%3BBraun%2C+M+M%3BBeeler%2C+J+A%3BSalive%2C+M+E&rft.aulast=Ball&rft.aufirst=R&rft.date=2001-02-01&rft.volume=20&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=08913668&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pediatr Infect Dis J. 2001 Aug;20(8):818-9 [11734756] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dose-response trend tests for tumorigenesis adjusted for differences in survival and body weight across doses. AN - 70641087; 11158714 AB - A relationship between rodent body weight and tumor incidence for some tissue/organ sites has been demonstrated in many studies. It is not uncommon for a chemical tested for carcinogenicity to also affect body weight due to toxicity and/or food consumption. In such cases, comparisons of tumor incidence may be biased by body weight differences across dose groups. A simple procedure was investigated for reducing this bias. This procedure divides the animals into a few groups on the basis of body weight. Body weight at 12 months was used, before the appearance of a tumor was likely to affect body weight. Statistics for dose-response trend tests are calculated within body weight strata and pooled to obtain an overall dose-response trend test. This procedure is analogous to stratifying animals on the basis of age at the time of removal from a study to account for differences in ages of animals across dose groups that can affect comparisons of tumor incidence. In this paper, differences in survival times of animals were adjusted by the Poly-3 technique used by the National Toxicology Program. This technique does not require the assignment of cause of death. Several examples from rodent chronic bioassays were investigated, where the high dose group had reduced body weights and associated reductions in tumor incidence. When we analyzed the data by body weight strata, some positive dose-response trends for tumor incidence were demonstrated. In one case, the body weight adjusted analysis indicated that a negative dose-response trend in tumor incidence was a real effect in addition to a body weight reduction. These examples indicate that it is important to consider the effects of body weight changes as low as 10%, and perhaps less, as possibly being caused by chemicals in 2-year bioassays for carcinogenesis. The simple procedure of analyzing tumor incidence within body weight strata can reduce the bias introduced by body weight differences across dose groups. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Gaylor, D W AU - Kodell, R L AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 219 EP - 225 VL - 59 IS - 2 SN - 1096-6080, 1096-6080 KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Survival Rate KW - Dose-Response Relationship, Drug KW - Mice KW - Body Weight KW - Neoplasms -- mortality KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Data Interpretation, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70641087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Dose-response+trend+tests+for+tumorigenesis+adjusted+for+differences+in+survival+and+body+weight+across+doses.&rft.au=Gaylor%2C+D+W%3BKodell%2C+R+L&rft.aulast=Gaylor&rft.aufirst=D&rft.date=2001-02-01&rft.volume=59&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunoassay for viable Cryptosporidium parvum oocysts in turbid environmental water samples. AN - 70635864; 11227892 AB - Cryptosporidium parvum oocysts in drinking water have been implicated in outbreaks of diarrheal disease. Current methods for monitoring environmental exposures to C. parvum only account for total number of oocysts without regard for the viability of the parasite. Measurement of oocyst viability, as indicated by an oocyst's ability to excyst, is useful because over time oocysts lose the ability to excyst and become noninfective. Thus, correlating the number of viable oocysts in drinking water with incidence and risk for disease should be more reliable than using the total number of oocysts. We have developed a quantitative assay capable of detecting low numbers of excystable, sporozoite-releasing C. parvum oocysts in turbid water samples. Monoclonal (CP7) and polyclonal antibodies have been developed against a sporozoite antigen released only during excystation or when the oocyst is mechanically disrupted. CP7 is specific for C. parvum and does not react with C. baileyi, C. muris, C. serpentis, Giardia spp., Eimeria spp., or E. nieschulzi. In this assay, oocysts in the test sample are first excysted and then centrifuged. The soluble sporozoite antigen is captured by CP7 attached to a magnetic bead. The captured antigen is then detected by ruthenium-labeled polyclonal antibodies via electrochemiluminescence. The CP7 viability assay can detect as few as 50 viable oocysts in a 1-ml assay sample with a turbidity as high as 200 Nephelometric turbidity units. This sensitive, turbidity-tolerant assay for oocyst viability may permit a better assessment of the disease risk associated with the presence of environmental oocysts. JF - The Journal of parasitology AU - Call, J L AU - Arrowood, M AU - Xie, L T AU - Hancock, K AU - Tsang, V C AD - National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 203 EP - 210 VL - 87 IS - 1 SN - 0022-3395, 0022-3395 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Protozoan KW - Antigens, Protozoan KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Immunoassay -- methods KW - Cryptosporidiosis -- parasitology KW - Antigens, Protozoan -- analysis KW - Humans KW - Antibodies, Protozoan -- immunology KW - Antibodies, Monoclonal -- immunology KW - Cryptosporidium parvum -- immunology KW - Cryptosporidium parvum -- growth & development KW - Water Pollution KW - Cryptosporidium parvum -- isolation & purification KW - Cryptosporidium parvum -- pathogenicity KW - Fresh Water -- parasitology KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70635864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+parasitology&rft.atitle=Immunoassay+for+viable+Cryptosporidium+parvum+oocysts+in+turbid+environmental+water+samples.&rft.au=Call%2C+J+L%3BArrowood%2C+M%3BXie%2C+L+T%3BHancock%2C+K%3BTsang%2C+V+C&rft.aulast=Call&rft.aufirst=J&rft.date=2001-02-01&rft.volume=87&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+parasitology&rft.issn=00223395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase. AN - 70633501; 11158245 AB - The use of methamphetamine (METH) leads to neurotoxic effects in mammals. These neurotoxic effects appear to be related to the production of free radicals. To assess the role of peroxynitrite in METH-induced dopaminergic, we investigated the production of 3-nitrotyrosine (3-NT) in the mouse striatum. The levels of 3-NT increased in the striatum of wild-type mice treated with multiple doses of METH (4 x 10 mg/kg, 2 h interval) as compared with the controls. However, no significant production of 3-NT was observed either in the striata of neuronal nitric oxide synthase knockout mice (nNOS -/-) or copper-zinc superoxide dismutase overexpressed transgenic mice (SOD-Tg) treated with similar doses of METH. The dopaminergic damage induced by METH treatment was also attenuated in nNOS-/- or SOD-Tg mice. These data further confirm that METH causes its neurotoxic effects via the production of peroxynitrite. JF - Journal of neurochemistry AU - Imam, S Z AU - Newport, G D AU - Itzhak, Y AU - Cadet, J L AU - Islam, F AU - Slikker, W AU - Ali, S F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 745 EP - 749 VL - 76 IS - 3 SN - 0022-3042, 0022-3042 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Uptake Inhibitors KW - Neurotoxins KW - Nitrates KW - peroxynitric acid KW - 26404-66-0 KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Methamphetamine KW - 44RAL3456C KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type I KW - Nos1 protein, mouse KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Reference Values KW - Mice, Knockout -- genetics KW - Nitric Oxide Synthase -- genetics KW - Corpus Striatum -- metabolism KW - Mice, Inbred C57BL KW - Superoxide Dismutase -- metabolism KW - Mice KW - Central Nervous System Stimulants -- pharmacology KW - Methamphetamine -- pharmacology KW - Neurotoxins -- pharmacology KW - Dopamine -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Nitrates -- physiology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70633501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Peroxynitrite+plays+a+role+in+methamphetamine-induced+dopaminergic+neurotoxicity%3A+evidence+from+mice+lacking+neuronal+nitric+oxide+synthase+gene+or+overexpressing+copper-zinc+superoxide+dismutase.&rft.au=Imam%2C+S+Z%3BNewport%2C+G+D%3BItzhak%2C+Y%3BCadet%2C+J+L%3BIslam%2C+F%3BSlikker%2C+W%3BAli%2C+S+F&rft.aulast=Imam&rft.aufirst=S&rft.date=2001-02-01&rft.volume=76&rft.issue=3&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research recommendations of the NORA exposure assessment methods team. National Occupational Research Agenda. AN - 70609965; 11217734 JF - Applied occupational and environmental hygiene AU - Abell, M T AU - Woebkenberg, M L AU - Armstrong, T W AU - Stenzel, M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 331 EP - 333 VL - 16 IS - 2 SN - 1047-322X, 1047-322X KW - Index Medicus KW - United States KW - Humans KW - Organizational Objectives KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure -- statistics & numerical data KW - Health Planning Councils KW - Safety Management -- methods KW - Databases, Factual KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70609965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Research+recommendations+of+the+NORA+exposure+assessment+methods+team.+National+Occupational+Research+Agenda.&rft.au=Abell%2C+M+T%3BWoebkenberg%2C+M+L%3BArmstrong%2C+T+W%3BStenzel%2C+M&rft.aulast=Abell&rft.aufirst=M&rft.date=2001-02-01&rft.volume=16&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Misinterpretation and misuse of exposure limits. AN - 70602203; 11217719 AB - Users of occupational exposure limits (OELs) often fail to distinguish between the complementary processes of risk assessment and exposure (risk) management. The former refers to those activities that lead to the selection of a reasonably protective exposure limit and often includes an analysis of exposure databases and an evaluation of group-based risk. The latter focuses on individual risk, and refers to those actions required of employers to ensure that each employee is unlikely to incur harm to health. This presentation focuses on how this failure to distinguish leads to misinterpretation and misuse of OELs. A typical OEL definition consists of at least three components: a concentration, an averaging time, and a target (usually the individual worker). OELs are occasionally improperly applied, resulting in a reduction of the expected level of protection. For example, sampling strategies proposed by the American Industrial Hygiene Association (AIHA) and Comité Européen de Normalisation (CEN) permit workers to be aggregated into exposure groups. Under certain circumstances this practice can leave some workers unevaluated and unprotected. Protection is also reduced when the averaging time is extended from a single shift to multiple shifts. Frequently, OELs are misinterpreted as upper limits to exposures averaged over weeks, months, or even years, rather than a single shift. Much of this confusion can be traced to the desire of some to reconcile research (epidemiology) sampling strategies with compliance sampling strategies. But the two have fundamentally different goals and objectives. Others are simply attracted to alternative OEL interpretations that permit frequent overexposures (i.e., measurements that exceed the OEL), thus making compliance easier. Given the current limitations of industrial hygiene and occupational epidemiology, and the general unwillingness of employers to routinely collect exposure data, OELs should continue to be defined as upper limits for single shift exposures. The current OEL model, which permits the use of proximate risk management goals to realize long-range objectives, should be retained. There are, however, valid reasons for augmenting this model to include criteria for evaluating compliance with long-range objectives. The augmented OEL model would be applicable to future new and revised OELs. The author suggests that OEL setting organizations consider harmonizing definitions and statistical interpretations for both existing and new OELs, thus minimizing future misinterpretation and misuse. JF - Applied occupational and environmental hygiene AU - Hewett, P AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 251 EP - 256 VL - 16 IS - 2 SN - 1047-322X, 1047-322X KW - Index Medicus KW - United States KW - Maximum Allowable Concentration KW - Humans KW - Reference Standards KW - Europe KW - Risk Assessment KW - Threshold Limit Values KW - Facility Regulation and Control KW - Occupational Exposure -- standards KW - Risk Management KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Misinterpretation+and+misuse+of+exposure+limits.&rft.au=Hewett%2C+P&rft.aulast=Hewett&rft.aufirst=P&rft.date=2001-02-01&rft.volume=16&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a National Occupational Exposure Survey and Database associated with NIOSH hazard surveillance initiatives. AN - 70601821; 11217699 AB - NIOSH pioneered hazard surveillance in the workplace by designing and conducting the 1972 to 1974 National Occupational Hazard Survey (NOHS), the 1981 to 1983 National Occupational Exposure Survey (NOES), and the 1984 to 1989 National Occupational Health Survey of Mining (NOHSM). The databases developed from these three on-site surveys represent unique resources for associating potential chemical, physical and biological agents with industries and occupational groups. The data have been a primary source of information for NIOSH, regulatory agencies, health professionals, researchers, and labor organizations in establishing priorities for prevention strategies that include medical and engineering interventions, development of occupational standards, and the identification of research needs. Recognizing that the data from these surveys are becoming dated, a multidisciplinary team comprising members from various NIOSH research divisions was established to develop a hazard surveillance strategy for the Institute, including options for a national hazard surveillance survey and database. The proposed new hazard survey builds on lessons learned from the previous surveys, seeks opportunities to incorporate existing data from other sources, expands the scope of industries and hazards, and takes advantage of advances in data gathering, processing and dissemination technology. This article presents current considerations and recommendations for a new hazard survey and database. JF - Applied occupational and environmental hygiene AU - Boiano, J M AU - Hull, R D AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 128 EP - 134 VL - 16 IS - 2 SN - 1047-322X, 1047-322X KW - Index Medicus KW - United States KW - Data Collection -- methods KW - Humans KW - Research Design KW - National Institute for Occupational Safety and Health (U.S.) KW - Internet KW - Occupational Exposure -- statistics & numerical data KW - Safety Management -- methods KW - Databases, Factual UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70601821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Development+of+a+National+Occupational+Exposure+Survey+and+Database+associated+with+NIOSH+hazard+surveillance+initiatives.&rft.au=Boiano%2C+J+M%3BHull%2C+R+D&rft.aulast=Boiano&rft.aufirst=J&rft.date=2001-02-01&rft.volume=16&rft.issue=2&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A field evaluation of the effect of pulsed arc welding technique on reducing worker exposures. AN - 70599608; 11217736 JF - Applied occupational and environmental hygiene AU - Wallace, M AU - Landon, D AU - Song, R AU - Echt, A AD - Division of Applied Research and Technology, NIOSH, Cincinnati, Ohio 45226, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 93 EP - 97 VL - 16 IS - 2 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Regression Analysis KW - Equipment Design KW - Analysis of Variance KW - Electric Power Supplies KW - Humans KW - Organizational Case Studies KW - Occupational Exposure -- prevention & control KW - Air Pollutants, Occupational -- analysis KW - Welding -- instrumentation KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70599608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=A+field+evaluation+of+the+effect+of+pulsed+arc+welding+technique+on+reducing+worker+exposures.&rft.au=Wallace%2C+M%3BLandon%2C+D%3BSong%2C+R%3BEcht%2C+A&rft.aulast=Wallace&rft.aufirst=M&rft.date=2001-02-01&rft.volume=16&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality in dry-cleaning workers: an update. AN - 70597672; 11170155 AB - A cohort of 1,708 dry-cleaning workers identified from union records was exposed to perchloroethylene (PCE), a known animal carcinogen and probable human carcinogen, for at least 1 year before 1960. Many workers also had exposure to Stoddard solvent, a petroleum-based dry-cleaning solvent. Vital status was updated through 1996 and life table analyses conducted. The cohort had excess cancer mortality (271 deaths, standardized mortality ratio [SMR] 1.25, 95% confidence interval [CI] 1.11-1.41). Elevated SMRs for tongue, bladder, esophagus, intestine, lung, and cervical cancer, pneumonia, and diseases of the stomach and duodenum were statistically significant. The current study confirms findings of prior updates and other studies that dry-cleaning workers have excess cancer mortality at several sites. Although important lifestyle and socioeconomic risk factors exist for both cervical and esophageal cancer mortality, excesses of these sites in the PCE only subcohort and among workers with longer duration of PCE exposure suggest an association with PCE exposure. Copyright 2001 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Ruder, A M AU - Ward, E M AU - Brown, D P AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. amr2@cdc.gov Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 121 EP - 132 VL - 39 IS - 2 SN - 0271-3586, 0271-3586 KW - Carcinogens KW - 0 KW - Hydrocarbons KW - Solvents KW - Stoddard solvent KW - 8052-41-3 KW - Tetrachloroethylene KW - TJ904HH8SN KW - Index Medicus KW - Life Tables KW - Neoplasms -- mortality KW - Humans KW - Cohort Studies KW - Aged KW - United States -- epidemiology KW - Hydrocarbons -- adverse effects KW - Male KW - Female KW - Cause of Death KW - Carcinogens -- adverse effects KW - Mortality KW - Solvents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Laundering KW - Tetrachloroethylene -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70597672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Mortality+in+dry-cleaning+workers%3A+an+update.&rft.au=Ruder%2C+A+M%3BWard%2C+E+M%3BBrown%2C+D+P&rft.aulast=Ruder&rft.aufirst=A&rft.date=2001-02-01&rft.volume=39&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues. AN - 70585582; 11156691 AB - Cytochrome P450 1B1 (CYP1B1) is a recently cloned dioxin-inducible form of the cytochrome P450 supergene family of xenobiotic-metabolizing enzymes. CYP1B1 is constitutively expressed mainly in extrahepatic tissues and is inducible by aryl hydrocarbon receptor ligands. Human CYP1B1 is involved in activation of chemically diverse human procarcinogens, including polycyclic aromatic hydrocarbons and some aromatic amines, as well as the endogenous hormone 17 beta-estradiol. The metabolism of 17 beta-estradiol by CYP1B1 forms 4-hydroxyestradiol, a product believed to be important in estrogen-induced carcinogenesis. Although the distribution of CYP1B1 mRNA and protein in a number of human normal tissues has been well documented, neither the cells expressing CYP1B1 in individual tissue nor the intracellular localization of the enzyme has been thoroughly characterized. In this study, using nonradioactive in situ hybridization and immunohistochemistry, we examined the cellular localization of CYP1B1 mRNA and protein in a range of human normal tissues. CYP1B1 mRNA and protein were expressed in most samples of parenchymal and stromal tissue from brain, kidney, prostate, breast, cervix, uterus, ovary, and lymph nodes. In most tissues, CYP1B1 immunostaining was nuclear. However, in tubule cells of kidney and secretory cells of mammary gland, immunoreactivity for CYP1B1 protein was found in both nucleus and cytoplasm. This study demonstrates for the first time the nuclear localization of CYP1B1 protein. Moreover, the constitutive expression and wide distribution of CYP1B1 mRNA and protein in many human normal tissues suggest functional roles for CYP1B1 in the bioactivation of xenobiotic procarcinogens and endogenous substrates such as estrogens. (J Histochem Cytochem 49:229-236, 2001) JF - The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society AU - Muskhelishvili, L AU - Thompson, P A AU - Kusewitt, D F AU - Wang, C AU - Kadlubar, F F AD - Pathology Associates International, Jefferson, Arkansas 72079, USA. lmuskhelishvili@nctr.fda.gov Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 229 EP - 236 VL - 49 IS - 2 SN - 0022-1554, 0022-1554 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - In Situ Hybridization KW - Cell Nucleus -- enzymology KW - Stromal Cells -- ultrastructure KW - Humans KW - Stromal Cells -- enzymology KW - Gene Expression KW - Organ Specificity KW - Cytoplasm -- enzymology KW - Immunohistochemistry KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70585582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+histochemistry+and+cytochemistry+%3A+official+journal+of+the+Histochemistry+Society&rft.atitle=In+situ+hybridization+and+immunohistochemical+analysis+of+cytochrome+P450+1B1+expression+in+human+normal+tissues.&rft.au=Muskhelishvili%2C+L%3BThompson%2C+P+A%3BKusewitt%2C+D+F%3BWang%2C+C%3BKadlubar%2C+F+F&rft.aulast=Muskhelishvili&rft.aufirst=L&rft.date=2001-02-01&rft.volume=49&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=The+journal+of+histochemistry+and+cytochemistry+%3A+official+journal+of+the+Histochemistry+Society&rft.issn=00221554&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - GEN T1 - Challenging Stereotypes: An Action Guide. Consumer Information Series, Volume 5. AN - 62351671; ED452458 AB - This booklet is intended to help decrease the barriers of prejudice toward people who have mental illnesses. It serves as an educational tool to eliminate the stigma associated with mental illness and to help develop anti-stigma or anti-discrimination programs. Increasingly, the media is doing a better job of breaking down the stereotypes associated with mental illness. Tools are provided in this publication to help promote fair, accurate, and balanced portrayals in the media. A seven-step guide is included on how to write an effective letter of complaint about unfair coverage of these issues in the media. Links are provided to groups with a common interest on the impact of widespread misconceptions on people who are coping with and recovering from mental illness. The 1999 surgeon general's call for action on mental health has invigorated a growing momentum to address the harm that prejudice and discrimination inflict upon millions. Anti-stigma and anti-discrimination work is critical. Through persistent, combined efforts, the mental health community can lead public opinion away from stereotypic thinking. A list of media directories for television, radio, and newspapers, and additional resources are included. (Contains 21 references.) (JDM) AU - Arnold, Jean AU - Weinerth, Nora Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 36 PB - CMHS Knowledge Exchange Network, 5600 Fishers Lane, Room 15-99, Rockville, MD 20857. Tel: 800-789-2647 (Toll Free). For full text: http://www.mentalhealth.org. KW - ERIC, Resources in Education (RIE) KW - Media Research KW - Social Action KW - Mental Disorders KW - Program Development KW - Social Discrimination KW - Mental Health KW - Bias KW - Mass Media Role UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62351671?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Performance of an Automatically Deployable ROPS on ASAE Tests AN - 17894591; 5140142 AB - In the U.S., approximately 132 agricultural tractor overturn fatalities occur per year. The use of rollover protective structures (ROPS), along with seat belts, is the best-known method for preventing these fatalities. However, one impediment to ROPS use is low-clearance situations, such as orchards and animal confinement buildings. To address the need for ROPS that are easily adapted to low-clearance situations, the Division of Safety Research, National Institute for Occupational Safety and Health, developed a prototype automatically deploying, telescoping ROPS (AutoROPS). The NIOSH AutoROPS consists of two subsystems. The first is a retractable ROPS that is normally latched in its lowered position for day-to-day use. The second subsystem is a sensor that monitors the operating angle of the tractor. If an overturn condition is detected by the sensor, the retracted ROPS will deploy and lock in the full upright position before ground contact. Static load testing and field upset tests of the NIOSH AutoROPS have been conducted in accordance with SAE standard J2194. Additionally, timed trials of the AutoROPS deployment mechanism were completed. The results of these tests show that the NIOSH AutoROPS has significant potential to overcome the limitations of current ROPS designs for use in low clearance as well as unrestricted clearance operations. JF - Journal of Agricultural Safety and Health AU - Powers, J R AU - Harris, J R AU - Etherton, J R AU - Snyder, KA AU - Ronaghi, M AU - Newbraugh, B H AD - Division of Safety Research, National Institute for Occupational Safety and Health 1095 Willowdale Road, Mail Stop P119, Morgantown, WV 26505, USA, jrel@cdc.gov Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 51 EP - 61 VL - 7 IS - 1 SN - 1074-7583, 1074-7583 KW - rollover protection KW - tractors KW - Risk Abstracts; Health & Safety Science Abstracts KW - Agriculture KW - Motor vehicles KW - Occupational safety KW - Protective equipment KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17894591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Performance+of+an+Automatically+Deployable+ROPS+on+ASAE+Tests&rft.au=Powers%2C+J+R%3BHarris%2C+J+R%3BEtherton%2C+J+R%3BSnyder%2C+KA%3BRonaghi%2C+M%3BNewbraugh%2C+B+H&rft.aulast=Powers&rft.aufirst=J&rft.date=2001-02-01&rft.volume=7&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Motor vehicles; Agriculture; Protective equipment; Occupational safety ER - TY - JOUR T1 - Lung cancer case-control study of beryllium workers AN - 17871612; 5111998 AB - Background: Cohort mortality studies have found elevated lung cancer mortality among beryllium-exposed workers, but none evaluated the association between beryllium exposure level and lung cancer risk. A nested case-control study of lung cancer within a beryllium processing plant was conducted to investigate the relationship between level of beryllium exposure and lung cancer. Methods: Lung cancer cases were identified by mortality follow-up through 1992 of a cohort of male workers at a beryllium alloy production plant. Each of 142 lung cancer cases was age-race-matched to five controls. Calendar-time-specific beryllium exposure estimates were made for every job in the plant and were used to estimate workers' cumulative, average, and maximum exposures. The potential confounding effects of smoking were also evaluated. Results: Lung cancer cases had shorter tenures and lower lifetime cumulative beryllium exposures than controls, but higher average and maximum exposures. However, after applying a 10- and 20-year lag, exposure metrics were higher for cases. Odds ratios in analyses lagged 20 years were significantly elevated for those with higher exposure compared to the lowest exposure category. Significant positive trends were seen with the log of the exposure metrics. Smoking did not appear to confound exposure-response analyses. Conclusions: Increased lung cancer among workers with higher lagged beryllium exposures and lack of evidence for confounding by cigarette smoking, provide further evidence that beryllium is a human lung carcinogen. JF - American Journal of Industrial Medicine AU - Sanderson, W T AU - Ward, E M AU - Steenland, K AU - Petersen, M R AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, wts1@cdc.gov Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 133 EP - 144 VL - 39 IS - 2 SN - 0271-3586, 0271-3586 KW - man KW - Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - Mortality KW - Lung diseases KW - Cancer KW - Cigarette smoking KW - Beryllium KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17871612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Lung+cancer+case-control+study+of+beryllium+workers&rft.au=Sanderson%2C+W+T%3BWard%2C+E+M%3BSteenland%2C+K%3BPetersen%2C+M+R&rft.aulast=Sanderson&rft.aufirst=W&rft.date=2001-02-01&rft.volume=39&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lung cancer; Occupational exposure; Beryllium; Risk assessment; Lung diseases; Cancer; Mortality; Cigarette smoking ER - TY - JOUR T1 - Estimating historical exposures of workers in a beryllium manufacturing plant AN - 17867505; 5111999 AB - Background: Beryllium is known to be toxic to the lungs, causing beryllium lung disease and associated with increased lung cancer risk. Airborne beryllium exposures have been monitored since the 1940s. This study describes methods used to measure airborne beryllium concentrations and how historical measurements from a beryllium manufacturing plant were used to estimate workers' exposures in a lung cancer case-control study. Methods: Airborne beryllium concentrations had been measured using all-glass impingers, high-volume air filters, and personal respirable and total dust samplers. To provide consistency in exposure estimates over time, measurements collected by the other monitoring methods were converted to approximate the most frequently used high-volume, time-weighted average measurements. Because industrial hygiene measurements were not collected in every year for all jobs throughout the duration of the case-control study, exposure estimates had to be extrapolated from the existing measurements over time and across jobs. Results: Over 7,000 historical measurements were available to estimate beryllium exposures of workers over time. Average exposures between jobs varied considerably and exposures for all jobs decreased dramatically between the 1940s and 1970s due to major plant production changes. Conclusions: Although error in the exposure metrics for the cases and controls likely occurred due to limitations of the exposure assessment data, the exposure estimates for each job over time provided a reasonable, objective mechanism for categorizing workers by the relative exposures they were likely to have encountered during their tenure. JF - American Journal of Industrial Medicine AU - Sanderson, W T AU - Petersen, M R AU - Ward, E M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio, USA, wts1@cdc.gov Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 145 EP - 157 VL - 39 IS - 2 SN - 0271-3586, 0271-3586 KW - man KW - exposure estimates KW - respiratory tract diseases KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Metals KW - Historical account KW - Manufacturing industry KW - Lung diseases KW - Cancer KW - Respiratory tract diseases KW - occupational diseases KW - Beryllium KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17867505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Estimating+historical+exposures+of+workers+in+a+beryllium+manufacturing+plant&rft.au=Sanderson%2C+W+T%3BPetersen%2C+M+R%3BWard%2C+E+M&rft.aulast=Sanderson&rft.aufirst=W&rft.date=2001-02-01&rft.volume=39&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Manufacturing industry; Occupational exposure; occupational diseases; Historical account; Beryllium; Respiratory tract diseases; Lung diseases; Metals; Cancer ER - TY - JOUR T1 - The Relative Buffering Capacities of Saliva and Moist Snuff: Implications for Nicotine Absorption AN - 17858086; 4882159 AB - Commercial moist snuff products are used by placing a portion of tobacco inside the mouth between the inner cheek or lip and gum. Nicotine is absorbed into the blood stream via transfer across various oral membranes including the buccal mucosa (cheek lining). The resulting salivary pH when a given moist snuff product is placed in the mouth is an important factor for nicotine absorption because it will affect the proportion of free base nicotine that is readily available for absorption. The resulting salivary pH for a given moist snuff product will be determined in part by the relative acid-base buffering capacities of the saliva and moist snuff, as well as the pHs of the saliva and moist snuff prior to coming in contact with one another. In the current study, the acid-base buffering capacities ( mu eq/g) of a series of commercial moist snuff products were determined and compared to the acid-base buffering capacity for unstimulated, whole human saliva. The buffering capacities of the moist snuff products were determined to be 10-20 times higher than the buffering capacity of human saliva. The resulting salivary pH ranges after contact between an artificial saliva and the various moist snuff products were also determined; the results were used to predict the proportion of free base nicotine that can be expected to occur in the mouth during the first few minutes of product use. These studies provide a basis for examining and understanding the effects that moist snuff product pHs and buffering capacities may be expected to have on nicotine absorption. JF - Journal of Analytical Toxicology AU - Ciolino, LA AU - McCauley, HA AU - Fraser, D B AU - Wolnik, KA AD - Food and Drug Administration, Forensic Chemistry Center, Cincinnati, Ohio 45237, USA Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 15 EP - 25 VL - 25 IS - 1 SN - 0146-4760, 0146-4760 KW - absorption KW - snuff KW - Toxicology Abstracts KW - Nicotine KW - Buffers KW - Tobacco KW - Saliva KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17858086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=The+Relative+Buffering+Capacities+of+Saliva+and+Moist+Snuff%3A+Implications+for+Nicotine+Absorption&rft.au=Ciolino%2C+LA%3BMcCauley%2C+HA%3BFraser%2C+D+B%3BWolnik%2C+KA&rft.aulast=Ciolino&rft.aufirst=LA&rft.date=2001-02-01&rft.volume=25&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Buffers; Nicotine; Tobacco; Saliva ER - TY - JOUR T1 - Construction and Consequences of Directed Mutations Affecting the Hemin Receptor in Pathogenic Corynebacterium Species AN - 17824479; 4859933 AB - Genes encoding an ATP-binding cassette transporter system involved in hemin iron utilization from Corynebacterium ulcerans were cloned and characterized. The genes are homologous to a hemin transport system previously identified in Corynebacterium diphtheriae. Disruption of the hmuT gene, which encodes the putative hemin receptor, resulted in greatly reduced ability of C. ulcerans to use hemin or hemoglobin as an iron source. Inactivation of hmuT in C. diphtheriae by site-specific recombination had no effect on hemin utilization, which suggests that C. diphtheriae has an additional system for transporting hemin. JF - Journal of Bacteriology AU - Schmitt, M P AU - Drazek, E S AD - FDA/CBER/DBPAP, 8800 Rockville Pike, Bldg. 29, Room 108, Bethesda, MD 20892., schmitt@cber.fda.gov Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 1476 EP - 1481 VL - 183 IS - 4 SN - 0021-9193, 0021-9193 KW - hemin receptors KW - hmuT gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Recombination KW - Gene disruption KW - ABC transporter KW - Nucleotide sequence KW - Corynebacterium ulcerans KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17824479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Construction+and+Consequences+of+Directed+Mutations+Affecting+the+Hemin+Receptor+in+Pathogenic+Corynebacterium+Species&rft.au=Schmitt%2C+M+P%3BDrazek%2C+E+S&rft.aulast=Schmitt&rft.aufirst=M&rft.date=2001-02-01&rft.volume=183&rft.issue=4&rft.spage=1476&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.183.4.1476-1481.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Corynebacterium ulcerans; ABC transporter; Gene disruption; Recombination; Nucleotide sequence DO - http://dx.doi.org/10.1128/JB.183.4.1476-1481.2001 ER - TY - JOUR T1 - Use of a Quantitative Product-Enhanced Reverse Transcriptase Assay to Monitor Retrovirus Levels in mAb Cell-Culture and Downstream Processing AN - 17813567; 4856360 AB - Murine hybridoma cells used in the production of monoclonal antibodies (mAb's) produce endogenous type C retrovirus particles. Regulatory agencies require a demonstration that mAb's intended for human use are free of retrovirus with an adequate margin of safety. This is usually achieved by validation studies, performed at small scale, to demonstrate that the manufacturing process is capable of removing or inactivating several different model viruses, including a murine retrovirus. In this report, we assess the utility of the TaqMan fluorogenic 5'-nuclease Product-Enhanced Reverse Transcriptase (TM-PERT) assay for measuring reverse transcriptase (RT) activity in cell-culture samples and RT removal by models of processing steps. The levels of RT activity contained in laboratory-scale cell-culture harvests (10 super(8)-10 super(13) pU/mL) were substantially above the detection limit of the TM-PERT assay ( similar to 10 super(6) pU/mL). The nature of the RT activity from cell culture was complex, but the bulk of RT activity in clarified mAb harvests appears to be contained in large molecular weight viral particles. In laboratory-scale chromatographic runs, sufficient RT activity was present in mAb-containing eluates to accurately calculate its log sub(10) reduction value (LRV), typically between 2 and 4 log sub(10) per step. Monoclonal antibody purified using a model purification scheme consisting of three serial columns contained some residual RT activity near the limit of detection. The data indicate that the TM-PERT assay, because it is quantitative and highly sensitive and can be used to analyze a large number of samples in a short period, is ideally suited to investigate and optimize retrovirus clearance in purification processes. JF - Biotechnology Progress AU - Brorson, K AU - Swann, P G AU - Lizzio, E AU - Maudru, T AU - Peden, K AU - Stein, KE AD - Divisions of Monoclonal Antibodies and Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, Maryland 20892, USA Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 188 EP - 196 VL - 17 IS - 1 SN - 8756-7938, 8756-7938 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts KW - Retrovirus KW - Monoclonal antibodies KW - RNA-directed DNA polymerase KW - Assays KW - Cell culture KW - N 14722:DNA polymerases KW - W 30965:Miscellaneous, Reviews KW - W3 33220:Cell culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17813567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Progress&rft.atitle=Use+of+a+Quantitative+Product-Enhanced+Reverse+Transcriptase+Assay+to+Monitor+Retrovirus+Levels+in+mAb+Cell-Culture+and+Downstream+Processing&rft.au=Brorson%2C+K%3BSwann%2C+P+G%3BLizzio%2C+E%3BMaudru%2C+T%3BPeden%2C+K%3BStein%2C+KE&rft.aulast=Brorson&rft.aufirst=K&rft.date=2001-02-01&rft.volume=17&rft.issue=1&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Progress&rft.issn=87567938&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Retrovirus; Assays; Monoclonal antibodies; Cell culture; RNA-directed DNA polymerase ER - TY - JOUR T1 - New Generation Tuberculosis Vaccines AN - 17809257; 4851277 AB - Pulmonary tuberculosis is the most important, life-threatening bacterial disease we face in the world today, infecting an estimated 1.7 billion people and responsible for nearly 3 million deaths annually. Virulent strains of tubercle bacilli that have been maintained for long periods on laboratory media usually become progressively attenuated. Calmette and Guerin used a similar approach to attenuate a virulent strain of Mycobacterium bovis by cultivating it on glycerol-potato-bile medium for 230 consecutive transfers, by which time, the organism had lost the ability to cause disease in a variety of experimental animals. With the recent publication of the M. tuberculosis genome, it now becomes possible to pursue a more rational approach to vaccine development. However, any resulting vaccine still faces a number of technical hurdles before it can be tested in humans. JF - Clinical Microbiology Newsletter AU - Collins, F M AD - Laboratory of Mycobacterial Diseases, CBER, Food and Drug Administration, Rockville, MD 20852, USA Y1 - 2001/02/01/ PY - 2001 DA - 2001 Feb 01 SP - 17 EP - 23 VL - 23 IS - 3 SN - 0196-4399, 0196-4399 KW - virulence factors KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Tuberculosis KW - Vaccines KW - Mycobacterium bovis KW - Mycobacterium tuberculosis KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17809257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=New+Generation+Tuberculosis+Vaccines&rft.au=Collins%2C+F+M&rft.aulast=Collins&rft.aufirst=F&rft.date=2001-02-01&rft.volume=23&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium bovis; Mycobacterium tuberculosis; Tuberculosis; Vaccines; Genomes ER - TY - JOUR T1 - Impact of added rest breaks on the productivity and well being of workers AN - 17756789; 6047799 AB - The impact of frequent short rest breaks on the productivity and well being of a group of 30 workers in a meat-processing plant was studied. Two rest break schedules were tested, both of which provided 36 min of extra break time over the regular break schedule (30-min lunch and two 15-min breaks). In the first experimental rest break schedule, workers were given 12 3-min breaks evenly distributed over the workday (3-min break for every 27 min of work). In the second schedule, workers were given four 9-min breaks evenly distributed over the workday (9-min break every 51 min of work). Outcome measures included production rate and discomfort and stress ratings. Results showed that neither of the two experimental rest break schedules had a negative effect on production, and the 9-min break schedule improved discomfort ratings for the lower extremities. The workers in the study mostly preferred the 9-min rest break schedule, indicating that workers in general might not as readily accept fragmentation of break time into short, frequent breaks. JF - Ergonomics AU - Dababneh, A J AU - Swanson, N AU - Shell, R L AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, C24, Cincinnati, OH 45226-1998, USA Y1 - 2001/02/01/ PY - 2001 DA - 2001 Feb 01 SP - 164 EP - 174 VL - 44 IS - 2 SN - 0014-0139, 0014-0139 KW - rest breaks KW - Health & Safety Science Abstracts KW - Stress KW - Working conditions KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17756789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Impact+of+added+rest+breaks+on+the+productivity+and+well+being+of+workers&rft.au=Dababneh%2C+A+J%3BSwanson%2C+N%3BShell%2C+R+L&rft.aulast=Dababneh&rft.aufirst=A&rft.date=2001-02-01&rft.volume=44&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Working conditions; Occupational health; Stress ER - TY - JOUR T1 - Diagnosis and management of foodborne illnesses: a primer for physicians. AN - 70575682; 11214980 AB - This primer is directed to primary care physicians, who are more likely to see the index case of a potential food-related disease outbreak. It is a teaching tool to update primary care physicians about foodborne illness and remind them of their important role in recognizing suspicious symptoms, disease clusters, and etiologic agents, and reporting cases of foodborne illness to public health authorities. JF - MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports AU - American Medical Association AU - Centers for Disease Control and Prevention AU - Center for Food Safety and Applied Nutrition, Food and Drug Administration AU - Food Safety and Inspection Service, US Department of Agriculture AD - American Medical Association ; Centers for Disease Control and Prevention ; Center for Food Safety and Applied Nutrition, Food and Drug Administration ; Food Safety and Inspection Service, US Department of Agriculture Y1 - 2001/01/26/ PY - 2001 DA - 2001 Jan 26 SP - 1 EP - 69 VL - 50 SN - 1057-5987, 1057-5987 KW - Index Medicus KW - Disease Outbreaks -- prevention & control KW - Humans KW - Foodborne Diseases -- epidemiology KW - Foodborne Diseases -- diagnosis KW - Foodborne Diseases -- prevention & control KW - Foodborne Diseases -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.atitle=Diagnosis+and+management+of+foodborne+illnesses%3A+a+primer+for+physicians.&rft.au=American+Medical+Association%3BCenters+for+Disease+Control+and+Prevention%3BCenter+for+Food+Safety+and+Applied+Nutrition%2C+Food+and+Drug+Administration%3BFood+Safety+and+Inspection+Service%2C+US+Department+of+Agriculture&rft.aulast=American+Medical+Association&rft.aufirst=&rft.date=2001-01-26&rft.volume=50&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.issn=10575987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genomics: implications for toxicology. AN - 70624038; 11166022 AB - The primary goal of the Environmental Genome Project (EGP) is the identification of human polymorphisms indicative of susceptibility to specific environmental agents. Despite evidence for a substantial genetic contribution to disease variation in the population, progress towards identifying specific genes has been slow. To date, most of the advances in our understanding of human diseases has come from genetic analyses of monogenic diseases that affect a relatively small portion of the population. The principal strategy of the EGP involves resequencing DNA samples from populations representative of the US racial and ethnic groups to develop a database of variations. Polymorphisms in specific genes may also be detected by gene-expression profiling. The identification of polymorphisms by resequencing is straightforward, and can be accomplished with minimal difficulty. Gene-expression profiling is still problematic; however, determining the functional significance of the allelic variations will be a monumental challenge involving sophisticated proteomics and population-based and animal model studies. These studies will change radically the practice of public health and clinical medicine, and the approach to the development of pharmaceuticals. JF - Mutation research AU - Olden, K AU - Guthrie, J AD - Department of Health and Human Services, National Institute of Environmental Health Sciences and National Toxicology Program, National Institutes of Health, Research Triangle Park, NC 27709, USA. olden@niehs.nih.gov Y1 - 2001/01/25/ PY - 2001 DA - 2001 Jan 25 SP - 3 EP - 10 VL - 473 IS - 1 SN - 0027-5107, 0027-5107 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Polymorphism, Genetic -- genetics KW - Humans KW - Hazardous Substances -- toxicity KW - Genetic Predisposition to Disease -- ethnology KW - Genetic Predisposition to Disease -- genetics KW - Genetic Predisposition to Disease -- epidemiology KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70624038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Genomics%3A+implications+for+toxicology.&rft.au=Olden%2C+K%3BGuthrie%2C+J&rft.aulast=Olden&rft.aufirst=K&rft.date=2001-01-25&rft.volume=473&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A practical three-dimensional reconstruction method to measure the volume of the sexually-dimorphic central nucleus of the medial preoptic area (MPOC) of the rat hypothalamus. AN - 70642592; 11164237 AB - Published estimates of the volume of the sexually-dimorphic central nucleus of the medial preoptic area (MPOC) have been quite variable both within and between laboratories. To obtain MPOC volume, most experimenters began with a two-dimensional (2-D) approach. They outlined the MPOC on each of several individual sections; then they added up the area contained on each section and multiplied the total by the section thickness. A 3-D reconstruction approach, although promising, has been somewhat impractical until recently due to the requirements for highly specialized software and massive computing support. Here, we describe the application of commercially-available PC-based software to measure MPOC volume by 3-D reconstruction. Male and female Sprague-Dawley rats, 24 or 50 days of age, were perfusion-fixed with 10% neutral phosphate-buffered formaldehyde. Following processing and embedding, a series of 20-microm sagittal paraffin sections were cut and mounted onto slides. After staining with cresyl violet, they were digitized using a microscope-mounted video camera connected to a frame-grabber in a Pentium-class computer (MCID-M5+). In addition to the MPOC, the anterior commissure, fornix, paraventricular nucleus, medial division of the bed nucleus of the stria terminalis, third ventricle and the bed nucleus of the anterior commissure were identified on the screen image and outlined using a computer mouse. These outlines were then aligned and rendered in 3-D with a solid overlay. The additional areas, such as anterior commissure, form landmarks within 3-D space to improve the accuracy with which the MPOC may be located and outlined. The reconstruction provides a striking illustration of the geometric relations between the structures of the anterior hypothalamus in the male and female rat. Moreover, the volumes determined from the overlays were reproducible between repeated studies in our laboratory. Our volume measurements confirm the sexual dimorphism previously reported for MPOC volumes, and provide a relatively quick, accurate and reliable protocol that should be useful in future experimental studies of environmental estrogenic compounds. JF - Journal of neuroscience methods AU - Meredith, J M AU - Bennett, C AU - Scallet, A C AD - Division of Neurotoxicology, National Center for Toxicological Research, USFDA, 3900 NCTR Drive, Jefferson, AR 72079-9502, USA. Y1 - 2001/01/15/ PY - 2001 DA - 2001 Jan 15 SP - 113 EP - 121 VL - 104 IS - 2 SN - 0165-0270, 0165-0270 KW - Index Medicus KW - Rats KW - Software KW - Animals KW - Rats, Sprague-Dawley KW - Image Enhancement -- methods KW - Male KW - Female KW - Hypothalamus -- physiology KW - Sex Characteristics KW - Preoptic Area -- physiology KW - Preoptic Area -- anatomy & histology KW - Imaging, Three-Dimensional -- methods KW - Hypothalamus -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70642592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+methods&rft.atitle=A+practical+three-dimensional+reconstruction+method+to+measure+the+volume+of+the+sexually-dimorphic+central+nucleus+of+the+medial+preoptic+area+%28MPOC%29+of+the+rat+hypothalamus.&rft.au=Meredith%2C+J+M%3BBennett%2C+C%3BScallet%2C+A+C&rft.aulast=Meredith&rft.aufirst=J&rft.date=2001-01-15&rft.volume=104&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+methods&rft.issn=01650270&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic Activation of the Tumorigenic Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo AN - 17860225; 5105474 AB - Riddelliine is a representative naturally occurring genotoxic pyrrolizidine alkaloid. We have studied the mechanism by which riddelliine induces hepatocellular tumors in vivo. Metabolism of riddelliine by liver microsomes of F344 female rats generated riddelliine N-oxide and dehydroretronecine (DHR) as major metabolites. Metabolism was enhanced when liver microsomes from phenobarbital-treated rats were used. Metabolism in the presence of calf thymus DNA resulted in eight DNA adducts that were identical to those obtained from the reaction of DHR with calf thymus DNA. Two of these adducts were identified as DHR-modified 7-deoxyguanosin-N super(2)-yl epimers (DHR-3'-dGMP); the other six were DHR-derived DNA adducts, but their structures were not characterized. A similar DNA adduct profile was detected in the livers of female F344 rats fed riddelliine, and a dose-response relationship was obtained for the level of the total (eight) DHR-derived DNA adducts and the level of the DHR-3'-dGMP adducts. These results suggest that riddelliine induces liver tumors in rats through a genotoxic mechanism and the eight DHR-derived DNA adducts are likely to contribute to liver tumor development. JF - Chemical Research in Toxicology AU - Yang, Ya-Chen AU - Yan, Jian AU - Doerge AU - Chan, Po-Cheun AU - Fu, P P AU - Chou, Ming W AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Y1 - 2001/01/15/ PY - 2001 DA - 2001 Jan 15 SP - 101 EP - 109 VL - 14 IS - 1 SN - 0893-228X, 0893-228X KW - metabolites KW - metabolic activation KW - rats KW - Riddelliine KW - pyrrolizidine alkaloids KW - Toxicology Abstracts KW - DNA adducts KW - Alkaloids KW - Microsomes KW - Genotoxicity KW - Liver KW - Tumors KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17860225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Metabolic+Activation+of+the+Tumorigenic+Alkaloid%2C+Riddelliine%2C+Leading+to+DNA+Adduct+Formation+in+Vivo&rft.au=Yang%2C+Ya-Chen%3BYan%2C+Jian%3BDoerge%3BChan%2C+Po-Cheun%3BFu%2C+P+P%3BChou%2C+Ming+W&rft.aulast=Yang&rft.aufirst=Ya-Chen&rft.date=2001-01-15&rft.volume=14&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Liver; Microsomes; Genotoxicity; Tumors; Alkaloids; DNA adducts ER - TY - JOUR T1 - Development of a super(32)P-Postlabeling/HPLC Method for Detection of Dehydroretronecine-Derived DNA Adducts in Vivo and in Vitro AN - 17860197; 5105473 AB - Pyrrolizidine alkaloids are naturally occurring genotoxic chemicals produced by a large number of plants. Metabolism of pyrrolizidine alkaloids in vivo and in vitro generates dehydroretronecine (DHR) as a common reactive metabolite. In this study, we report the development of a super(32)P-postlabeling/HPLC method for detection of (i) two DHR-3'-dGMP and four DHR-3'-dAMP adducts and (ii) a set of eight DHR-derived DNA adducts in vitro and in vivo. The approach involves (1) synthesis of DHR-3'-dGMP, DHR-3'-dAMP, and DHR-3',5'-dG-bisphosphate standards and characterization of their structures by mass and super(1)H NMR spectral analyses, (2) development of optimal conditions for enzymatic DNA digestion, adduct enrichment, and super(32)P-postlabeling, and (3) development of optimal HPLC conditions. Using this methodology, we have detected eight DHR-derived DNA adducts, including the two epimeric DHR-3',5'-dG-bisphosphate adducts both in vitro and in vivo. JF - Chemical Research in Toxicology AU - Yang, Ya-Chen AU - Yan, Jian AU - Churchwell, M AU - Beger, R AU - Chan, Po-Cheun AU - Doerge AU - Fu, P P AU - Chou, Ming W AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Y1 - 2001/01/15/ PY - 2001 DA - 2001 Jan 15 SP - 91 EP - 100 VL - 14 IS - 1 SN - 0893-228X, 0893-228X KW - Dehydroretronecine KW - pyrrolizidine alkaloids KW - Toxicology Abstracts KW - High-performance liquid chromatography KW - DNA adducts KW - Alkaloids KW - Radioisotopes KW - Plants KW - Genotoxicity testing KW - Toxicity testing KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17860197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Development+of+a+super%2832%29P-Postlabeling%2FHPLC+Method+for+Detection+of+Dehydroretronecine-Derived+DNA+Adducts+in+Vivo+and+in+Vitro&rft.au=Yang%2C+Ya-Chen%3BYan%2C+Jian%3BChurchwell%2C+M%3BBeger%2C+R%3BChan%2C+Po-Cheun%3BDoerge%3BFu%2C+P+P%3BChou%2C+Ming+W&rft.aulast=Yang&rft.aufirst=Ya-Chen&rft.date=2001-01-15&rft.volume=14&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Genotoxicity testing; Toxicity testing; Plants; Alkaloids; DNA adducts; High-performance liquid chromatography; Radioisotopes ER - TY - JOUR T1 - Protective immunity against herpes simplex virus generated by DNA vaccination compared to natural infection AN - 17775218; 4830606 AB - To evaluate the utility of plasmid DNA vaccination against disease caused by herpes simplex virus (HSV), we compared the strength of protection against lethal challenge following natural virus infection with that following vaccination with a plasmid encoding HSV glycoprotein gD (gD-DNA). We further determined the cellular basis of each type of protection using lymphocyte deficient knockout mice. Establishment of immunity to HSV using live virus immunization required CD8 super(+) T cells and B cells, but not CD4 super(+) or gamma / delta super(+) T cells, and was related to specific antibody levels; surprisingly, CD4 knockout mice had large quantities of IgG anti-HSV serum antibodies. Establishment of immunity to HSV using gD-DNA immunization approached the strength of that generated following sublethal infection, but was dependent on alpha / beta super(+) CD4 super(+) T cells, CD8 super(+) T cells, B cells, and even partially on gamma / delta super(+) T cells, and not strictly correlated with antibody levels. JF - Vaccine AU - Nass, PH AU - Elkins, K L AU - Weir, J P AD - Division of Viral Products, Center for Biologics Evaluation and Research, HFM-457, 1401 Rockville Pike, Rockville, MD 20852, USA, weirj@cber.fda.gov Y1 - 2001/01/08/ PY - 2001 DA - 2001 Jan 08 SP - 1538 EP - 1546 VL - 19 IS - 11-12 SN - 0264-410X, 0264-410X KW - HSV KW - immunology KW - man KW - glycoprotein D KW - glycoprotein gD KW - herpes simplex virus KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - DNA vaccines KW - Vaccines KW - Plasmids KW - Herpes simplex virus KW - F 06807:Active immunization KW - V 22097:Immunization: Vaccines & vaccination: Human KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17775218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Protective+immunity+against+herpes+simplex+virus+generated+by+DNA+vaccination+compared+to+natural+infection&rft.au=Nass%2C+PH%3BElkins%2C+K+L%3BWeir%2C+J+P&rft.aulast=Nass&rft.aufirst=PH&rft.date=2001-01-08&rft.volume=19&rft.issue=11-12&rft.spage=1538&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Herpes simplex virus; DNA vaccines; Vaccines; Plasmids ER - TY - JOUR T1 - Grading the severity of allergic rhinitis for treatment strategy and drug study purposes AN - 879669455; 11892041 AB - Grading the severity of rhinitis symptoms is essential for the evaluation of drug efficacy. However, a uniform grading system has not been standardized. A review of 44 journal articles and symposia from Japan, Copenhagen, and the World Health Organization indicates major differences among systems. All except the World Health Organization used a sum of rhinitis scores. The lack of standardization limits comparisons of subjective symptom changes after comparable treatments. Corrective measures include the use of evidence-based definitions of independent nasal symptoms, avoidance of biases in evaluation, and establishment of international consensus for a standardized scale in this era of globalization.[PUBLICATION ABSTRACT] JF - Current Allergy Reports AU - Okuda, Minoru, MD, PhD Y1 - 2001 PY - 2001 DA - 2001 SP - 235 EP - 41 CY - Philadelphia PB - Springer Science & Business Media VL - 1 IS - 3 KW - Medical Sciences--Respiratory Diseases KW - Allergies KW - United States KW - Severity of Illness Index KW - Asthma -- drug therapy KW - Rhinitis, Allergic, Perennial -- complications KW - Humans KW - United States Food & Drug Administration KW - Treatment Outcome KW - Japan KW - Rhinitis, Vasomotor -- drug therapy KW - Rhinitis, Vasomotor -- complications KW - Drug Therapy -- standards KW - Asthma -- complications KW - Rhinitis, Allergic, Perennial -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879669455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Allergy+Reports&rft.atitle=Grading+the+severity+of+allergic+rhinitis+for+treatment+strategy+and+drug+study+purposes&rft.au=Okuda%2C+Minoru%2C+MD%2C+PhD&rft.aulast=Okuda&rft.aufirst=Minoru&rft.date=2001-01-01&rft.volume=1&rft.issue=3&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Current+Allergy+Reports&rft.issn=&rft_id=info:doi/10.1007%2Fs11882-001-0010-x LA - English DB - ProQuest Central N1 - Copyright - Current Science Inc. 2001 N1 - Last updated - 2013-01-28 DO - http://dx.doi.org/10.1007/s11882-001-0010-x ER - TY - JOUR T1 - Ergonomic job design to accommodate and prevent musculoskeletal disabilities. AN - 85365212; pmid-12530836 AB - Work-related musculoskeletal disorders (MSDs) account for a major portion of the cost of work-related injury and illness in the United States. Many of these injuries and illnesses lead to temporary or permanent disability. It is generally accepted that the incidence of MSDs increases when the demands of the job exceed the capabilities of the worker. As the workforce ages and physical capabilities decline, it is anticipated that many more Americans will request disability-related leave resulting from musculoskeletal disorders because they are unable to meet the demands of the job. To prevent these disabilities and to accommodate a wider range of people in the workforce, physical job demands may have to be reduced so that a larger portion of the population will be capable of working. Providing engineering controls or alternative work arrangements allows for accommodation of workers with a wide range of capabilities and can assist in rehabilitation and early return to work following injury. JF - Assistive technology : the official journal of RESNA AU - Waters, T R AU - MacDonald, L A AD - Human Factors and Ergonomics Research Section, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 88 EP - 93 VL - 13 IS - 2 SN - 1040-0435, 1040-0435 KW - Health technology assessment KW - National Library of Medicine KW - *Cumulative Trauma Disorders: prevention & control KW - *Human Engineering KW - Humans KW - *Musculoskeletal Diseases: prevention & control KW - *Occupational Diseases: prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85365212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assistive+technology+%3A+the+official+journal+of+RESNA&rft.atitle=Ergonomic+job+design+to+accommodate+and+prevent+musculoskeletal+disabilities.&rft.au=Waters%2C+T+R%3BMacDonald%2C+L+A&rft.aulast=Waters&rft.aufirst=T&rft.date=2001-01-01&rft.volume=13&rft.issue=2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Assistive+technology+%3A+the+official+journal+of+RESNA&rft.issn=10400435&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - GEN T1 - Toxicology at the Food and Drug Administration: new century, new challenges. AN - 77019597; 11288931 AB - Dr. Schwetz is the Acting Deputy Commissioner of the Food and Drug Administration (FDA). He was Director of FDA National Center for Toxicological Research in Jefferson, AR, from 1993 to 1999. A diplomate of the American Board of Toxicology, Dr. Schwetz was acting Director of the Environmental Toxicology Program at the National Institutes of Health National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, NC, before coming to the FDA in 1993. He was also Associate Director of the National Toxicology program there. He had been Chief of the Institute Systems Toxicity Branch since 1982. Dr. Schwetz currently serves as Adjunct Professor, Department of Pharmacology and Toxicology/Division of Interdisciplinary Toxicology, at the University of Arkansas for Medical Sciences. He was editor of Fundamental and Applied Toxicology from 1986 to 1992, and serves on the Editorial Advisory Board of Environmental Health Perspectives and Critical Reviews in Toxicology. Dr. Schwetz is an invited member of the Canada Health Protection Branch Science Advisory Board, and an elected member of the National Academy of Sciences Institute of Medicine. He is a member of the Society of Toxicology (SOT) and the National Capitol Area Chapter, SOT; the American Veterinary Medical Association; National Society of Phi Zeta, Honor Society of Veterinary Medicine; Teratology Society; Behavioral Teratology Society; and the Reproductive Toxicology Specialty Section of the SOT. He is past president of the Reproductive Toxicology Specialty Section of the SOT and of the North Carolina and the South Central Chapters of the SOT. In addition to numerous other professional awards during his career, Dr. Schwetz received the U.S. Government 1998 Meritorious Executive Presidential Rank Award. JF - International journal of toxicology AU - Schwetz, B A PY - 2001 SP - 3 EP - 8 VL - 20 IS - 1 KW - Index Medicus KW - United States KW - Humans KW - United States Food and Drug Administration KW - Toxicology -- trends KW - Toxicology -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77019597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=International+journal+of+toxicology&rft.atitle=Toxicology+at+the+Food+and+Drug+Administration%3A+new+century%2C+new+challenges.&rft.au=Schwetz%2C+B+A&rft.aulast=Schwetz&rft.aufirst=B&rft.date=2001-01-01&rft.volume=20&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=International+journal+of+toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-04-05 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Inhibition of lignin peroxidase-mediated oxidation activity by ethylenediamine tetraacetic acid and N-N-N'-N'-tetramethylenediamine. AN - 76969479; 11254169 AB - The mineralization rate of LC-[1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane] (DDT) was reduced by 90% on the 18th day in fungal cultures of Phanerochaete chrysosporium in the presence of 8 mM ethylenediamine tetraacetic acid (EDTA). In the presence of 8 mM N-N-N'-N'-tetramethylenediamine (TEMED), the mineralization rate of 14C-DDT was reduced by 80%. In the presence of 2 mM or 10 mM EDTA, 95% inhibition of lignin peroxidase (LiP) mediated veratryl alcohol oxidase activity and 97% inhibition of LiP mediated iodide oxidase activity occurred. TEMED caused 79% inhibition of veratryl alcohol oxidase activity and 92% inhibition of iodide oxidase activity when the amount used was 2 mM and 10 mM, respectively. In the presence of Zn(II) with slight molar excess of the EDTA concentration, reversed the EDTA mediated non-competitive inhibition of LiP catalyzed veratryl alcohol or iodide oxidation, Zn(II) also reversed the inhibition of LiP catalyzed veratryl alcohol oxidase activity caused by chelators other than EDTA and TEMED. In addition to Zn(II), several other metal ions also relieved EDTA mediated inhibition of veratryl alcohol and iodide oxidase activity catalyzed by LiP. The ability of veratryl alcohol to inhibit iodide oxidation catalyzed by LiP showed that veratryl alcohol could inhibit LiP mediated iodide oxidase activity. Increasing the concentration of iodide was also shown to inhibit veratryl alcohol oxidation. Kinetic analysis showed that the reaction was competitive inhibition. JF - Proceedings of the National Science Council, Republic of China. Part B, Life sciences AU - Chang, H C AU - Bumpus, J A AD - Division of Biochemical Toxicology, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR, USA. Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 26 EP - 33 VL - 25 IS - 1 SN - 0255-6596, 0255-6596 KW - Chelating Agents KW - 0 KW - Enzyme Inhibitors KW - Ethylenediamines KW - Fungal Proteins KW - N,N,N',N'-tetramethylethylenediamine KW - 110-18-9 KW - Potassium Iodide KW - 1C4QK22F9J KW - Edetic Acid KW - 9G34HU7RV0 KW - DDT KW - CIW5S16655 KW - Alcohol Oxidoreductases KW - EC 1.1.- KW - veratryl alcohol oxidase KW - EC 1.1.3.- KW - Peroxidases KW - EC 1.11.1.- KW - lignin peroxidase KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Oxidation-Reduction KW - Potassium Iodide -- metabolism KW - Zinc -- pharmacology KW - Alcohol Oxidoreductases -- antagonists & inhibitors KW - DDT -- metabolism KW - Binding, Competitive KW - Biodegradation, Environmental KW - Alcohol Oxidoreductases -- metabolism KW - Potassium Iodide -- pharmacology KW - Binding Sites KW - Phanerochaete -- enzymology KW - Peroxidases -- antagonists & inhibitors KW - Chelating Agents -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Fungal Proteins -- antagonists & inhibitors KW - Ethylenediamines -- pharmacology KW - Edetic Acid -- pharmacology KW - Peroxidases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76969479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Science+Council%2C+Republic+of+China.+Part+B%2C+Life+sciences&rft.atitle=Inhibition+of+lignin+peroxidase-mediated+oxidation+activity+by+ethylenediamine+tetraacetic+acid+and+N-N-N%27-N%27-tetramethylenediamine.&rft.au=Chang%2C+H+C%3BBumpus%2C+J+A&rft.aulast=Chang&rft.aufirst=H&rft.date=2001-01-01&rft.volume=25&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Science+Council%2C+Republic+of+China.+Part+B%2C+Life+sciences&rft.issn=02556596&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hand-transmitted vibration and biodynamic response of the human hand-arm: a critical review. AN - 72424046; 11822480 AB - Hand-arm vibration syndrome (HAVS) has been associated with prolonged exposure to vibration transmitted to the human hand-arm system from hand-held power tools, vibrating machines, or hand-held vibrating workpieces. The biodynamic response of the human hand and arm to hand transmitted vibration (HTV) forms an essential basis for effective evaluations of exposures, vibration-attenuation mechanisms, and potential injury mechanisms. The biodynamic response to HTV and its relationship to HAVS are critically reviewed and discussed to highlight the advances and the need for further research. In view of its strong dependence on the nature of HTV and the lack of general agreement on the characteristics of HTV, the reported studies are first reviewed to enhance an understanding of HTV and related issues. The characteristics of HTV and relevant unresolved issues are discussed on the basis of measured data, proposed standards, and measurement methods, while the need for further developments in measurement systems is emphasized. The studies on biodynamic response and their findings are grouped into four categories based on the methodology used and the objective. These include studies on (1) through-the-hand-arm response, expressed in terms of vibration transmissibility; (2) to-the-hand response, expressed in terms of the force-motion relationship of the hand-arm system; (3) to-the-hand biodynamic response function, expressed in terms of vibration energy absorption; and (4) computer modeling of the biodynamic response characteristics. JF - Critical reviews in biomedical engineering AU - Dong, R G AU - Rakheja, S AU - Schopper, A W AU - Han, B AU - Smutz, W P AD - Engineering & Control Technology Branch, NIOSH, Morgantown, WV 26505, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 393 EP - 439 VL - 29 IS - 4 SN - 0278-940X, 0278-940X KW - Index Medicus KW - Occupational Exposure -- prevention & control KW - Occupational Exposure -- standards KW - Gloves, Protective -- standards KW - Humans KW - Movement -- physiology KW - Torque KW - Equipment Safety -- methods KW - Rotation KW - Fourier Analysis KW - Time Factors KW - Weight-Bearing KW - Elasticity KW - Arm -- physiopathology KW - Arm Injuries -- prevention & control KW - Arm Injuries -- etiology KW - Models, Biological KW - Arm Injuries -- physiopathology KW - Vibration -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72424046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+biomedical+engineering&rft.atitle=Hand-transmitted+vibration+and+biodynamic+response+of+the+human+hand-arm%3A+a+critical+review.&rft.au=Dong%2C+R+G%3BRakheja%2C+S%3BSchopper%2C+A+W%3BHan%2C+B%3BSmutz%2C+W+P&rft.aulast=Dong&rft.aufirst=R&rft.date=2001-01-01&rft.volume=29&rft.issue=4&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+biomedical+engineering&rft.issn=0278940X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-02 N1 - Date created - 2002-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transgenic animal models that might be useful in identifying unsuspected oncogenic factors in tumour cell substrates. AN - 72335492; 11761226 AB - The use of alternative short term models for the assessment of pharmaceutical carcinogenicity potential is expanding and evolving. Several mouse models of accelerated carcinogenesis have gained user confidence and are being applied to product development decision-making. These models have been highlighted as part of a consortium effort organized under ILSI to further evaluate their strengths and limitations compared to the standard two-years, two species cancer bioassay. Examples of trends that are developing in our understanding of applicability of these models to chemical carcinogenesis have been presented but a more comprehensive review of all the currently available data has been avoided. Such a review would be soon outdated as the anticipated data from the ILSI consortium studies will soon become available and greatly further impact our present appreciation of the capabilities of these models. As strengths and limitations of those models are being elucidated, mechanistic understanding of the models is expanding. In addition to those reviewed briefly in this paper, numerous other transgenic models with micro-injected oncogenes and disrupted tumour suppressor genes have demonstrated enhanced propensity for developing cancer. Critical experiments can be designed to test, conceptually, for the ability of any of these models to detect tumorigenic potential for a given dose of adventitious agent, or residual DNA sequence. The choice of model and of DNA sequence or adventitious agent to begin this evaluation must be carefully considered. From such data, risk may be better identified or prioritized, but such approaches may not be practical as general routine screens of finished vaccine product with unknown residual DNA sequence or adventitious agents. JF - Developments in biologicals AU - Sistare, F D AD - Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 123 EP - 31; discussion 131-2, 143-60 VL - 106 SN - 1424-6074, 1424-6074 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals, Newborn KW - Animals KW - Tumor Cells, Cultured KW - Mice KW - Animals, Genetically Modified KW - Mice, Transgenic KW - Mice, Knockout KW - Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72335492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developments+in+biologicals&rft.atitle=Transgenic+animal+models+that+might+be+useful+in+identifying+unsuspected+oncogenic+factors+in+tumour+cell+substrates.&rft.au=Sistare%2C+F+D&rft.aulast=Sistare&rft.aufirst=F&rft.date=2001-01-01&rft.volume=106&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Developments+in+biologicals&rft.issn=14246074&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-08 N1 - Date created - 2001-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ibogaine neurotoxicity assessment: electrophysiological, neurochemical, and neurohistological methods. AN - 72276572; 11705108 JF - The Alkaloids. Chemistry and biology AU - Binienda, Z K AU - Scallet, A C AU - Schmued, L C AU - Ali, S F AD - Division of Neurotoxicology, FDA/National Center for Toxicological Research, Jefferson, AR 72079-9502, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 193 EP - 210 VL - 56 SN - 1099-4831, 1099-4831 KW - Neurotransmitter Agents KW - 0 KW - Ibogaine KW - 3S814I130U KW - Index Medicus KW - Animals KW - Neurotransmitter Agents -- metabolism KW - Humans KW - Electroencephalography -- drug effects KW - Genes, fos KW - Ibogaine -- toxicity KW - Brain -- pathology KW - Brain -- drug effects KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72276572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Alkaloids.+Chemistry+and+biology&rft.atitle=Ibogaine+neurotoxicity+assessment%3A+electrophysiological%2C+neurochemical%2C+and+neurohistological+methods.&rft.au=Binienda%2C+Z+K%3BScallet%2C+A+C%3BSchmued%2C+L+C%3BAli%2C+S+F&rft.aulast=Binienda&rft.aufirst=Z&rft.date=2001-01-01&rft.volume=56&rft.issue=&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=The+Alkaloids.+Chemistry+and+biology&rft.issn=10994831&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sex, ethnicity, age and education effects on the Trail Making test in a sample of cocaine abusers. AN - 72267491; 11699194 AB - Sex, ethnicity, age and education effects on the Trail Making test (TMT), a test often used to for screen for cognitive impairment, were examined in a sample of cocaine abusers in drug abuse treatment programs. A mixed race sample of 5116 males and 2614 females was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 programs in 11 cities in the United States. The number of cocaine/crack abuser scores available for analysis was 4306. Data were analyzed to determine the effects of sex, ethnicity, age and education variables on the two parts of the TMT in this large treatment sample of cocaine abusers. The variables of sex age, ethnicity and education were statistically significant for both parts A and B of the TMT. In addition, R-Square values for overall models were quite weak (A = .08, B = .11) suggesting that sex, ethnicity, age and education effects on the TMT, while clearly present, account for relatively little overall variance in terms of cocaine users TMT performance. These results are consistent with earlier research using a more heterogenous drug abuse treatment sample. JF - The International journal of neuroscience AU - Horton, A M AU - Roberts, C AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD 20857, USA. ahorton@samhsa.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 281 EP - 290 VL - 108 IS - 3-4 SN - 0020-7454, 0020-7454 KW - Index Medicus KW - Educational Status KW - Age Factors KW - Sex Factors KW - Humans KW - Adult KW - Adolescent KW - Male KW - Female KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Neuropsychological Tests KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72267491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Sex%2C+ethnicity%2C+age+and+education+effects+on+the+Trail+Making+test+in+a+sample+of+cocaine+abusers.&rft.au=Horton%2C+A+M%3BRoberts%2C+C&rft.aulast=Horton&rft.aufirst=A&rft.date=2001-01-01&rft.volume=108&rft.issue=3-4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-02 N1 - Date created - 2001-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neonatal mouse model: review of methods and results. AN - 72252951; 11695548 AB - The neonatal mouse model, in various forms, has been used experimentally since 1959 and a large number of chemicals have been tested. The neonatal model is known to be very sensitive for the detection of carcinogens that operate via a genotoxic mode of action. In contrast, it is known not to respond to chemicals that act via epigenetic mechanisms, commonly observed in the two-year carcinogenicity studies. As such, the model has a high sensitivity and specificity in its response. Dose selection for the neonatal model is based on the maximum tolerated or feasible dose. Traditionally, compounds have been tested via the IP route of administration in this model. In some cases, this has limited the amount of material that can be administered because of the low dosing volumes (10 to 20 microL) that can be administered IP. For the ILSI project, the neonatal model was adapted for oral administration, which has the advantages of being the same route for which most pharmaceuticals are administered. In addition, a 10-fold increase in the volume of administration (100 to 200 microL) and the ability to dose drugs in suspension, permits much higher doses to be used as compared to the IP route of administration. The spontaneous tumors in the neonatal model occurred mainly in the liver of male mice and lung of male and female mice with a few tumors observed in the Harderian gland. The positive control, DEN produced a robust, uniform, and reproducible tumor response with the target organs essentially limited to liver and lung. A total of 13 compounds out of the 21 ILSI ACT compounds were evaluated in the neonatal model involving 18 studies with duplicate studies for some compounds. The genotoxic carcinogens including those used as positive controls were clearly positive (cyclophosphamide, diethylnitrosamine, 6-nitrochrysene). The non-genotoxic rodent carcinogens were clearly negative (chlorpromazine, sulfisoxazole, sulfamethoxazole, clofibrate, DEHP, haloperidol, metaproteranol, and phenobarbital). The non-genotoxic human carcinogen (cyclosporin) was clearly negative. The two other human carcinogens phenacetin and DES were negative and interestingly estradiol was negative in one of the two oral studies, but was clearly positive in the other. Considering the mode of action for three of the human carcinogens (DES, cyclosporin and phenacetin), which were negative in this model, the mode of action in humans is likely to be epigenetic. Overall, for the 3 clearly genotoxic chemicals, all were positive. For the 9 clearly non-genotoxic chemicals, all 9 were negative. The two human carcinogens for which genotoxicity may or may not play a role (DES and phenacetin) were negative and estradiol was positive in I of the two oral studies. Overall, the extensive database for compounds tested in the neonatal mouse model would support its use as an alternative model for the assessment of the carcinogenic potential of a chemical. The model responds to chemicals that act via a genotoxic mode of action that represent a greater concern for human cancer risk. JF - Toxicologic pathology AU - McClain, R M AU - Keller, D AU - Casciano, D AU - Fu, P AU - MacDonald, J AU - Popp, J AU - Sagartz, J AD - National Center for Toxicological Research, Food and Drug Administration, USA. michaelmcclain@msn.com Y1 - 2001 PY - 2001 DA - 2001 SP - 128 EP - 137 VL - 29 Suppl SN - 0192-6233, 0192-6233 KW - Carcinogens KW - 0 KW - Mutagens KW - Index Medicus KW - Sensitivity and Specificity KW - Administration, Oral KW - Mice, Inbred Strains KW - Animals, Newborn KW - Animals KW - Animal Testing Alternatives KW - Reproducibility of Results KW - Humans KW - Mice KW - Maximum Tolerated Dose KW - Male KW - Female KW - Carcinogens -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity KW - Carcinogenicity Tests -- methods KW - Mutagens -- toxicity KW - Disease Models, Animal KW - Neoplasms, Experimental -- pathology KW - Mutagens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72252951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Neonatal+mouse+model%3A+review+of+methods+and+results.&rft.au=McClain%2C+R+M%3BKeller%2C+D%3BCasciano%2C+D%3BFu%2C+P%3BMacDonald%2C+J%3BPopp%2C+J%3BSagartz%2C+J&rft.aulast=McClain&rft.aufirst=R&rft.date=2001-01-01&rft.volume=29+Suppl&rft.issue=&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-21 N1 - Date created - 2001-11-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Overexpressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy. AN - 72212837; 11642612 AB - A variety of human solid cancer cell lines and primary cell cultures has been reported to overexpress high-affinity receptors (R) for interleukin-4 (IL-4), a pleiotropic immunoregulatory cytokine. The significance of IL-4R expression is not known; however, IL-4 is able to upregulate adhesion molecules, inhibit cell proliferation, and mediate signal transduction in tumor cell lines. To target IL-4R, we produced a chimeric protein composed of a circular permuted IL-4 and a mutated form of Pseudomonas exotoxin [termed IL4(38-37)-PE38KDEL or cpIL4-PE]. The recombinant cpIL4-PE was highly cytotoxic to cancer cells, but not toxic to normal B cells, T cells, monocytes, and CD34+, even though these cells express detectable numbers of IL-4R. The cytotoxicity was specific because excess of recombinant IL-4 neutralized the cpIL4-PE effect. To further develop this molecule, in vivo antitumor activity was tested in animal models of human cancer. This agent showed remarkable antitumor activity in AIDS-Kaposi's sarcoma, glioblastoma multiforme, and breast cancer models in immunodeficient animals. cpIL4-PE caused partial or complete regression of established human tumors. Preclinical efficacy and toxicity studies provided a therapeutic window in which this cancer-targeted agent could be used. On the basis of these studies, we initiated a Phase I clinical trial for the treatment of recurrent glioblastoma multiforme. Our preliminary clinical results suggest that cpIL4-PE has antitumor activity against the deadliest form of brain tumors, without detectable toxicity to normal brain tissues. Thus, IL-4 receptors represent novel targets for cancer cytotoxin therapy. JF - Critical reviews in immunology AU - Kawakami, K AU - Kawakami, M AU - Puri, R K AD - Division of Celular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 299 EP - 310 VL - 21 IS - 1-3 SN - 1040-8401, 1040-8401 KW - Immunotoxins KW - 0 KW - Receptors, Interleukin-4 KW - interleukin 4 (38-37)-PE38KDEL KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials, Phase I as Topic KW - Tissue Distribution KW - Immunotoxins -- pharmacokinetics KW - Receptors, Interleukin-4 -- biosynthesis KW - Brain Neoplasms -- therapy KW - Immunotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72212837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+immunology&rft.atitle=Overexpressed+cell+surface+interleukin-4+receptor+molecules+can+be+successfully+targeted+for+antitumor+cytotoxin+therapy.&rft.au=Kawakami%2C+K%3BKawakami%2C+M%3BPuri%2C+R+K&rft.aulast=Kawakami&rft.aufirst=K&rft.date=2001-01-01&rft.volume=21&rft.issue=1-3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+immunology&rft.issn=10408401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-07 N1 - Date created - 2001-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of Dengue virus type 2 replicons capable of prolonged expression in host cells. AN - 71336099; 11580862 AB - As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we have begun to investigate the possibility of designing Dengue vaccines based on non-structural proteins. Dengue constructs which lack major structural proteins replicate intracellularly in tissue culture. These replicons are capable of prolonged expression of Dengue virus non-structural proteins for at least seven days in culture. Dengue virus genomes lacking major structural proteins can, like other flaviviruses, replicate intracellularly and express virus non-structural proteins with minimal toxicity to host cells. These findings pave the way for the development of dengue virus replicons as a form of live, attenuated virus vaccine. JF - BMC microbiology AU - Pang, X AU - Zhang, M AU - Dayton, A I AD - Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA. dayton@cber.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 18 VL - 1 KW - RNA, Viral KW - 0 KW - Index Medicus KW - Virus Replication KW - Cells, Cultured -- virology KW - Animals KW - Mice KW - Haplorhini KW - Replicon KW - Dengue Virus -- genetics KW - Dengue Virus -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71336099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+microbiology&rft.atitle=Development+of+Dengue+virus+type+2+replicons+capable+of+prolonged+expression+in+host+cells.&rft.au=Pang%2C+X%3BZhang%2C+M%3BDayton%2C+A+I&rft.aulast=Pang&rft.aufirst=X&rft.date=2001-01-01&rft.volume=1&rft.issue=&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=BMC+microbiology&rft.issn=1471-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-28 N1 - Date created - 2002-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Infect Dis. 1994 Sep;19(3):500-12 [7811870] Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2395-400 [8146129] J Virol. 1997 Jul;71(7):5366-74 [9188607] J Virol. 1997 Dec;71(12):9608-17 [9371625] Clin Diagn Virol. 1998 Jul 15;10(2-3):129-39 [9741638] Br Med Bull. 1998;54(2):395-405 [9830205] Vaccine. 2000 May 26;18 Suppl 2:44-7 [10821973] Virus Genes. 2000;20(1):57-63 [10766307] J Biotechnol. 1999 Aug 20;73(2-3):243-9 [10486933] Vaccine. 2001 Apr 30;19(23-24):3179-88 [11312014] Adv Virus Res. 1986;31:103-68 [2428213] J Gen Virol. 1987 Mar;68 ( Pt 3):853-7 [3819700] Science. 1988 Jan 29;239(4839):476-81 [3277268] J Gen Virol. 1988 Aug;69 ( Pt 8):2101-7 [3404125] J Virol. 1990 Sep;64(9):4356-63 [2143542] Annu Rev Microbiol. 1990;44:649-88 [2174669] J Virol. 1997 Feb;71(2):1497-505 [8995675] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV. AN - 71319225; 11747468 AB - Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective against dengue virus and HIV, we have attempted to create vectors which express dengue virus non-structural proteins and HIV immunogens. Previously we reported the successful construction of dengue virus replicons which lack structural genes necessary for virion release and spreading infection in culture but which can replicate intracellularly and abundantly produce dengue non-structural proteins. Here we attempted to express heterologous genetic material from these replicons. We cloned into a Deltapre-M/E dengue virus replicon genes for either green fluorescent protein (GFP), HIV gp160 or HIV gp120 and tested the ability of these constructs to express dengue virus proteins as well as the heterologous proteins in tissue culture after transfection of replicon RNA. Heterologous proteins were readily expressed from these constructs. GFP and gp120 demonstrated minimal or no toxicity. Gp160 expressing replicons were found to express proteins abundantly at 36 hours post transfection, but after 50 hrs of transfection, few replicon positive cells could be found despite the presence of cellular debris positive for replicon proteins. This suggested that gp160 expressed from dengue virus replicons is considerably more toxic than either GFP or gp120. The successful expression of heterologous proteins, including HIV gp120 for long periods in culture suggests this vector system may be useful as a vaccine vector, given appropriate delivery methods. JF - BMC microbiology AU - Pang, X AU - Zhang, M AU - Dayton, A I AD - Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA. pang@cber.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 28 VL - 1 KW - HIV Envelope Protein gp120 KW - 0 KW - RNA, Viral KW - Recombinant Proteins KW - Vaccines, Synthetic KW - Viral Vaccines KW - Index Medicus KW - Viral Vaccines -- administration & dosage KW - HIV-1 -- metabolism KW - HIV-1 -- genetics KW - Recombinant Proteins -- metabolism KW - HIV Infections -- prevention & control KW - Recombinant Proteins -- immunology KW - Vaccines, Synthetic -- administration & dosage KW - RNA, Viral -- genetics KW - Vaccination KW - Immunotherapy, Active -- methods KW - Dengue -- prevention & control KW - HIV Envelope Protein gp120 -- immunology KW - Dengue Virus -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV Envelope Protein gp120 -- genetics KW - Dengue Virus -- genetics KW - Dengue Virus -- metabolism KW - Replicon -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71319225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+microbiology&rft.atitle=Development+of+dengue+virus+replicons+expressing+HIV-1+gp120+and+other+heterologous+genes%3A+a+potential+future+tool+for+dual+vaccination+against+dengue+virus+and+HIV.&rft.au=Pang%2C+X%3BZhang%2C+M%3BDayton%2C+A+I&rft.aulast=Pang&rft.aufirst=X&rft.date=2001-01-01&rft.volume=1&rft.issue=&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=BMC+microbiology&rft.issn=1471-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-28 N1 - Date created - 2002-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Virus Res. 1986;31:103-68 [2428213] J Gen Virol. 1987 Mar;68 ( Pt 3):853-7 [3819700] Science. 1988 Jan 29;239(4839):476-81 [3277268] J Gen Virol. 1988 Aug;69 ( Pt 8):2101-7 [3404125] J Virol. 1990 Sep;64(9):4356-63 [2143542] Annu Rev Microbiol. 1990;44:649-88 [2174669] Immunol Lett. 1999 Mar;66(1-3):189-95 [10203054] J Infect Dis. 1992 Jun;165(6):1012-9 [1533867] J Infect Dis. 1992 Aug;166(2):244-52 [1353102] Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1882-6 [8446603] J Infect Dis. 1994 Jan;169(1):41-7 [8277196] Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2395-400 [8146129] Clin Infect Dis. 1994 Sep;19(3):500-12 [7811870] Science. 1995 Mar 24;267(5205):1820-5 [7892606] AIDS. 1995 Dec;9(12):F13-8 [8605046] J Virol. 1996 Jun;70(6):3741-52 [8648709] AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):993-9 [8827215] J Virol. 1997 Feb;71(2):1497-505 [8995675] J Virol. 1997 Mar;71(3):1911-21 [9032322] J Virol. 1997 Jul;71(7):5366-74 [9188607] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9378-83 [9256490] J Virol. 1997 Nov;71(11):8141-8 [9343164] Nat Med. 1998 Jun;4(6):679-84 [9623976] Cell. 1998 May 29;93(5):681-4 [9630213] J Virol. 1998 Oct;72(10):7846-51 [9733821] Clin Diagn Virol. 1998 Jul 15;10(2-3):129-39 [9741638] J Virol. 1999 Feb;73(2):1138-45 [9882315] N Engl J Med. 1999 Jan 21;340(3):236-7 [9917232] Science. 1999 Jan 15;283(5400):357-62 [9888845] Nat Med. 1999 Feb;5(2):194-203 [9930868] J Virol. 1999 May;73(5):3753-7 [10196269] BMC Microbiol. 2001;1:18 [11580862] Cell. 2001 Sep 7;106(5):539-49 [11551502] J Virol. 2001 Jun;75(12):5526-40 [11356960] Vaccine. 2001 Apr 30;19(23-24):3179-88 [11312014] Adv Pharmacol. 2000;49:263-314 [11013767] J Infect Dis. 2000 Aug;182(2):579-89 [10915092] Vaccine. 2000 May 26;18 Suppl 2:44-7 [10821973] Virus Genes. 2000;20(1):57-63 [10766307] C R Acad Sci III. 1999 Nov;322(11):959-66 [10646090] Lancet. 1991 Mar 9;337(8741):567-72 [1671940] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FDA's foods program. AN - 71305594; 11944638 JF - Food and drug law journal AU - Levitt, J A AD - Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration (FDA), USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 255 EP - 266 VL - 56 IS - 3 SN - 1064-590X, 1064-590X KW - Health technology assessment KW - United States KW - Food Contamination -- prevention & control KW - Public Health KW - Humans KW - Community Participation KW - Budgets -- statistics & numerical data KW - Research KW - Risk Assessment KW - United States Food and Drug Administration KW - Food Industry -- legislation & jurisprudence KW - Safety KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71305594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+drug+law+journal&rft.atitle=FDA%27s+foods+program.&rft.au=Levitt%2C+J+A&rft.aulast=Levitt&rft.aufirst=J&rft.date=2001-01-01&rft.volume=56&rft.issue=3&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Food+and+drug+law+journal&rft.issn=1064590X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-24 N1 - Date created - 2002-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Demographic effects on the Trail Making Test in sedatives abusers. AN - 71300440; 11912869 AB - Demographic effects on the Trail Making test (TMT), a test often used to screen for cognitive impairment, were examined in a sample of sedatives abusers in drug abuse treatment programs. A sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 programs in 11 cities in the United States. The number of sedatives abusers' scores available for analysis were 72. Data were analyzed to determine the effects of sex, ethnicity, age, and education variables on the two parts of the TMT in this large treatment sample of sedatives abusers. None of the demographic variables were statistically significantly related to TMT parts A and B, when considered as single variables. In addition, R-Square values for overall models were low (A = .15, B = .18), suggesting that demographic effects on the TMT in a sample of sedative abusers are very weak. JF - The International journal of neuroscience AU - Roberts, C AU - Horton, A R AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD 20857, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 189 EP - 195 VL - 110 IS - 3-4 SN - 0020-7454, 0020-7454 KW - Hypnotics and Sedatives KW - 0 KW - Index Medicus KW - Educational Status KW - Humans KW - Ethnic Groups -- statistics & numerical data KW - Age Distribution KW - Prospective Studies KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Trail Making Test KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Substance-Related Disorders -- complications KW - Hypnotics and Sedatives -- adverse effects KW - Cognition Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71300440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Demographic+effects+on+the+Trail+Making+Test+in+sedatives+abusers.&rft.au=Roberts%2C+C%3BHorton%2C+A+R&rft.aulast=Roberts&rft.aufirst=C&rft.date=2001-01-01&rft.volume=110&rft.issue=3-4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-10 N1 - Date created - 2002-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Demographic effects on the Trail Making Test in marijuana abusers. AN - 71299607; 11912867 AB - Demographic effects on the Trail Making Test (TMT), a test often used for screening for cognitive impairment, were examined in a sample of marijuana abusers in drug abuse treatment programs. A sample was drawn from electronic files of data from the Drug Abuse Treatment outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 programs in 11 cities in the United States. The number of marijuana abusers' scores available for analysis were 259. Data were analyzed to determine the effects of sex, ethnicity, age, and education variables on the two parts of the TMT in this large treatment sample of marijuana abusers. The variables of age and education level were statistically significantly related to TMT parts A and B, and ethnicity was statistically significant for part B of the TMT. R-Square values for overall models were moderate (A = .15, B = .18) suggesting that demographic effects on the TMT are weak. JF - The International journal of neuroscience AU - Horton, A M AU - Roberts, C AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD 20857, USA. ahorton@samhsa.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 173 EP - 180 VL - 110 IS - 3-4 SN - 0020-7454, 0020-7454 KW - Index Medicus KW - Educational Status KW - Humans KW - Ethnic Groups -- statistics & numerical data KW - Age Distribution KW - Prospective Studies KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Trail Making Test KW - Cognition Disorders -- diagnosis KW - Marijuana Abuse -- complications KW - Cognition Disorders -- epidemiology KW - Cognition Disorders -- chemically induced KW - Cognition Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71299607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Demographic+effects+on+the+Trail+Making+Test+in+marijuana+abusers.&rft.au=Horton%2C+A+M%3BRoberts%2C+C&rft.aulast=Horton&rft.aufirst=A&rft.date=2001-01-01&rft.volume=110&rft.issue=3-4&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-10 N1 - Date created - 2002-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Demographic effects on the Trail Making Test in amphetamine abusers. AN - 71298883; 11912868 AB - Demographic effects on the Trail Making Test (TMT), a test often used for screening for cognitive impairment, were examined in a sample of amphetamine abusers in drug abuse treatment programs. A sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993, in 96 programs in 11 cities in the United States. The number of amphetamine abusers scores available for analysis were 185. Data were analyzed to determine the effects of sex, ethnicity, age, and education variables on the two parts of the TMT in this large treatment sample of amphetamine abusers. No variables were statistically significant for either parts A and B of the TMT. R-square values for overall models were also negligible (A = .03, B = .08) suggesting that demographic effects on the TMT account for a minuscule amount of overall variance in terms of amphetamine abusers' TMT performance. JF - The International journal of neuroscience AU - Roberts, C AU - Horton, A M AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD 20857, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 181 EP - 187 VL - 110 IS - 3-4 SN - 0020-7454, 0020-7454 KW - Index Medicus KW - Educational Status KW - Humans KW - Ethnic Groups -- statistics & numerical data KW - Age Distribution KW - Prospective Studies KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Trail Making Test KW - Cognition Disorders -- diagnosis KW - Amphetamine-Related Disorders -- complications KW - Cognition Disorders -- epidemiology KW - Cognition Disorders -- chemically induced KW - Cognition Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71298883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Demographic+effects+on+the+Trail+Making+Test+in+amphetamine+abusers.&rft.au=Roberts%2C+C%3BHorton%2C+A+M&rft.aulast=Roberts&rft.aufirst=C&rft.date=2001-01-01&rft.volume=110&rft.issue=3-4&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-10 N1 - Date created - 2002-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Demographic effects on the Trail Making Test in narcotic/other opiate abusers. AN - 71290796; 11913331 AB - Demographic effects on the Trail Making Test (TMT), a test often used to screen for cognitive impairments, were examined in a sample of narcotic/other opiate abusers in drug abuse treatment programs. A sample was drawn from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991 through 1993 in 96 programs within 11 cities in the United States. The number of narcotic/other opiate abusers' scores available for analysis was 191. Data were analyzed to determine the effects of sex, ethnicity, age, and education on the two parts of the TMT in this sample of narcotic/other opiate abusers. The variables of age and education level were statistically significantly related to TMT parts A and B, and ethnicity was statistically significant for part B of the TMT. R-square values for overall models were moderate (A = .34, B = .24), suggesting that demographic effects on the TMT are moderate. JF - The International journal of neuroscience AU - Horton, A M AU - Roberts, C AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD 20857, USA. ahorton@samhsa.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 101 EP - 107 VL - 111 IS - 1-2 SN - 0020-7454, 0020-7454 KW - Narcotics KW - 0 KW - Index Medicus KW - Educational Status KW - Age Factors KW - Sex Factors KW - Humans KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Ethnic Groups -- statistics & numerical data KW - Trail Making Test KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Narcotics -- adverse effects KW - Substance-Related Disorders -- complications KW - Cognition Disorders -- chemically induced KW - Cognition Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71290796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Demographic+effects+on+the+Trail+Making+Test+in+narcotic%2Fother+opiate+abusers.&rft.au=Horton%2C+A+M%3BRoberts%2C+C&rft.aulast=Horton&rft.aufirst=A&rft.date=2001-01-01&rft.volume=111&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-07 N1 - Date created - 2002-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Derived trail making test indices in a sample of substance abusers: demographic effects. AN - 71288540; 11913334 AB - Derived indices on the Trail Making Test (TMT), a test often used to screen for cognitive impairments, were examined in a sample of substance abusers in drug abuse treatment programs. A mixed race sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991 through 1993 within 96 programs in 11 cities in the United States. Data were analyzed to determine the effects of demographic variables on derived indices created by adding, subtracting, multiplying, and dividing parts A and B of the TMT in this large treatment sample of substance abusers. The variables of sex, age, ethnicity, and education were statistically significant for selected derived indices of the TMT. JF - The International journal of neuroscience AU - Horton, A M AU - Roberts, C AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD 20857, USA. ahorton@samhsa.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 123 EP - 132 VL - 111 IS - 1-2 SN - 0020-7454, 0020-7454 KW - Index Medicus KW - Educational Status KW - Age Factors KW - Sex Factors KW - Humans KW - Adult KW - Substance-Related Disorders -- complications KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Ethnic Groups -- statistics & numerical data KW - Trail Making Test KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Cognition Disorders -- chemically induced KW - Cognition Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71288540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Derived+trail+making+test+indices+in+a+sample+of+substance+abusers%3A+demographic+effects.&rft.au=Horton%2C+A+M%3BRoberts%2C+C&rft.aulast=Horton&rft.aufirst=A&rft.date=2001-01-01&rft.volume=111&rft.issue=1-2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-07 N1 - Date created - 2002-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Strategies for the in vitro testing of in situ polymers. AN - 71278524; 11846990 AB - In situ polymers are used by mixing two or more compounds that are then placed directly in tissues to form a unique product. This type of reaction can generate heat, reactive oxygen species, free radicals, and other by-products of unknown toxicities, but the polymer itself is biocompatible. Many regulatory agencies require in vitro testing, however, standard guidelines (ASTM, ISO, AAMI) test polymers in a final form prior to use as a medical device. To better estimate the cytotoxicity of these in situ polymers, various means of introducing the reacting material to cells in culture were explored. Coating the material on a sterile glass cover slip then adding the cover slip to the in vitro test system immediately provided reasonable cytotoxicity data that reflected actual use conditions. For in situ polymeric devices that are more viscous, such as dental materials and bone cements, a mold was used that was placed directly into cell culture. This approach in testing in situ polymers generated in vitro toxicity data that reflects the actual use of the material. JF - In vitro & molecular toxicology AU - Lucas, A D AD - U.S. Food and Drug Administration, CDRH/OST, HFZ 112, 12709 Twinbrook Parkway, Rockville, Maryland 20852, USA. adl@cdrh.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 169 EP - 175 VL - 14 IS - 3 SN - 1097-9336, 1097-9336 KW - Biocompatible Materials KW - 0 KW - Polymers KW - Index Medicus KW - L Cells (Cell Line) KW - Animals KW - Cell Survival -- drug effects KW - Humans KW - In Vitro Techniques KW - Mice KW - Jurkat Cells -- drug effects KW - Biocompatible Materials -- toxicity KW - Materials Testing -- methods KW - Toxicity Tests -- methods KW - Polymers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71278524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vitro+%26+molecular+toxicology&rft.atitle=Strategies+for+the+in+vitro+testing+of+in+situ+polymers.&rft.au=Lucas%2C+A+D&rft.aulast=Lucas&rft.aufirst=A&rft.date=2001-01-01&rft.volume=14&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=In+vitro+%26+molecular+toxicology&rft.issn=10979336&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-26 N1 - Date created - 2002-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - From farm to table to brain: foodborne pathogen infection and the potential role of the neuro-immune-endocrine system in neurotoxic sequelae. AN - 71278354; 11845817 AB - The American diet is among the safest in the world; however, diseases transmitted by foodborne pathogens (FBPs) still pose a public health hazard. FBPs are the second most frequent cause of all infectious illnesses in the United States. Numerous anecdotal and clinical reports have demonstrated that central nervous system inflammation, infection, and adverse neurological effects occur as complications of foodborne gastroenteritis. Only a few well-controlled clinical or experimental studies, however, have investigated the neuropathogenesis. The full nature and extent of neurological involvement in foodborne illness is therefore unclear. To our knowledge, this review and commentary is the first effort to comprehensively discuss the issue of FBP induced neurotoxicity. We suggest that much of this information supports the role of a theoretical model, the neuro-immune-endocrine system, in organizing and helping to explain the complex pathogenesis of FBP neurotoxicity. JF - Nutritional neuroscience AU - Garthoff, L H AU - Sobotka, T J AD - United States FDA, Center for Food Safety & Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology and Nutrition Product Studies, Neurotoxicology Branch, Laurel, MD 20708, USA. lgarthof@cfsan.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 333 EP - 374 VL - 4 IS - 5 SN - 1028-415X, 1028-415X KW - Index Medicus KW - Animals KW - Gastroenteritis -- etiology KW - Food Microbiology KW - Humans KW - Brain -- embryology KW - Bacteremia KW - Neurodegenerative Diseases -- etiology KW - Female KW - Bacterial Infections -- transmission KW - Pregnancy KW - Bacterial Infections -- diagnosis KW - Infection -- transmission KW - Nervous System Diseases -- etiology KW - Endocrine Glands KW - Food Contamination KW - Immunity KW - Nervous System Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71278354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutritional+neuroscience&rft.atitle=From+farm+to+table+to+brain%3A+foodborne+pathogen+infection+and+the+potential+role+of+the+neuro-immune-endocrine+system+in+neurotoxic+sequelae.&rft.au=Garthoff%2C+L+H%3BSobotka%2C+T+J&rft.aulast=Garthoff&rft.aufirst=L&rft.date=2001-01-01&rft.volume=4&rft.issue=5&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Nutritional+neuroscience&rft.issn=1028415X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-28 N1 - Date created - 2002-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minimal effects from developmental exposure to St. John's wort (Hypericum perforatum) in Sprague-Dawley rats. AN - 71277981; 11842881 AB - Increasing widespread use of St. John's Wort (SJW, Hypericum perforatum) has led to concerns about its use in pregnant women. Behavioral and physiological alterations resulting from developmental treatment were investigated in Sprague-Dawley rats exposed to diets containing 0, 180, 900, 1800 or 4500ppm SJW beginning on gestational day 3 and ending at offspring weaning on postnatal day (PND) 21. These dietary doses span 1-25 times the recommended human dose. Post-weaning behavioral assessments of male and female offspring included: open field activity, acoustic startle, performance of complex and Morris water mazes, and activity in an elevated plus-maze. There were no SJW effects on maternal weight gain or duration of gestation; offspring body weights were similar to controls from PND 2 through PND 56 after which, some treated groups weighed significantly less than the controls. There were no SJW-related behavioral alterations on any measure. Whole and regional brain weights of offspring at adulthood indicated no significant effects of SJW. These results indicate that there are few neurobehavioral alterations resulting from developmental SJW treatment in rats. JF - Nutritional neuroscience AU - Cada, A M AU - Hansen, D K AU - LaBorde, J B AU - Ferguson, S A AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 135 EP - 141 VL - 4 IS - 2 SN - 1028-415X, 1028-415X KW - Plant Preparations KW - 0 KW - Index Medicus KW - Models, Animal KW - Animals KW - Reflex, Startle -- drug effects KW - Maze Learning -- drug effects KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Humans KW - Weaning KW - Organ Size KW - Pregnancy KW - Rats KW - Body Weight KW - Rats, Sprague-Dawley KW - Brain -- anatomy & histology KW - Motor Activity -- drug effects KW - Female KW - Male KW - Hypericum KW - Plant Preparations -- pharmacology KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71277981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutritional+neuroscience&rft.atitle=Minimal+effects+from+developmental+exposure+to+St.+John%27s+wort+%28Hypericum+perforatum%29+in+Sprague-Dawley+rats.&rft.au=Cada%2C+A+M%3BHansen%2C+D+K%3BLaBorde%2C+J+B%3BFerguson%2C+S+A&rft.aulast=Cada&rft.aufirst=A&rft.date=2001-01-01&rft.volume=4&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Nutritional+neuroscience&rft.issn=1028415X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-19 N1 - Date created - 2002-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis. AN - 71193686; 11570667 AB - Previous studies have determined that alpha-quartz (crystalline silica) can cause pulmonary inflammation, damage, and fibrosis. However, the temporal relationship between silica inhalation and pulmonary inflammation, damage, and fibrosis has not been fully examined. To address this gap in our knowledge of silica-induced pulmonary fibrosis, a chronic inhalation study using rats was designed. Specifically, rats were exposed to a silica aerosol (15 mg/m3 silica, 6 h/d, 5 d/wk, 116 d), and measurements of pulmonary inflammation, damage, and fibrosis were monitored throughout the study. We report (1) data demonstrating that the silica aerosol generation and exposure system produced a consistent silica aerosol of respirable size particles; (2) the time course of silica deposition in the lung; (3) calculations that demonstrate that the rats were not in pulmonary overload; (4) histopathological data demonstrating time-dependent enhancement of silica-induced alveolitis, epithelial hypertrophy and hyperplasia, alveolar lipoproteinosis, and pulmonary fibrosis in the absence of overload; and (5) biochemical data documenting the development of lipidosis, lung damage, and fibrosis. JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer AU - Porter, D W AU - Ramsey, D AU - Hubbs, A F AU - Battelli, L AU - Ma, J AU - Barger, M AU - Landsittel, D AU - Robinson, V A AU - McLaurin, J AU - Khan, A AU - Jones, W AU - Teass, A AU - Castranova, V AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 1 EP - 14 VL - 20 Suppl 1 SN - 0731-8898, 0731-8898 KW - Air Pollutants, Occupational KW - 0 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Particle Size KW - Body Burden KW - Lipidoses -- chemically induced KW - Bronchoalveolar Lavage KW - Administration, Inhalation KW - Time Factors KW - Male KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Silicon Dioxide -- administration & dosage KW - Lung -- drug effects KW - Silicon Dioxide -- toxicity KW - Lung -- pathology KW - Air Pollutants, Occupational -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71193686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.atitle=Time+course+of+pulmonary+response+of+rats+to+inhalation+of+crystalline+silica%3A+histological+results+and+biochemical+indices+of+damage%2C+lipidosis%2C+and+fibrosis.&rft.au=Porter%2C+D+W%3BRamsey%2C+D%3BHubbs%2C+A+F%3BBattelli%2C+L%3BMa%2C+J%3BBarger%2C+M%3BLandsittel%2C+D%3BRobinson%2C+V+A%3BMcLaurin%2C+J%3BKhan%2C+A%3BJones%2C+W%3BTeass%2C+A%3BCastranova%2C+V&rft.aulast=Porter&rft.aufirst=D&rft.date=2001-01-01&rft.volume=20+Suppl+1&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reactive oxygen species and molecular mechanism of silica-induced lung injury. AN - 71190488; 11570677 AB - Silica particles are considered to be fibrogenic and carcinogenic agents, but the mechanisms of disease initiation and progression are not fully understood. This article summarizes the literature on the generation of reactive oxygen species (ROS) directly from interaction of silica with aqueous medium and from silica-stimulated cells. This article also discusses the role of ROS in silica-induced lung injury, with particular focus on the silica-induced NF-kappaB activation, including the molecular mechanisms of its regulation, its possible attenuation, and its relationship to silica-induced generation of cyclooxygenase II and TNF-alpha. JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer AU - Shi, X AU - Ding, M AU - Chen, F AU - Wang, L AU - Rojanasakul, Y AU - Vallyathan, V AU - Castranova, V AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. xas0@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 85 EP - 93 VL - 20 Suppl 1 SN - 0731-8898, 0731-8898 KW - Air Pollutants, Occupational KW - 0 KW - Isoenzymes KW - Membrane Proteins KW - NF-kappa B KW - Reactive Oxygen Species KW - Tumor Necrosis Factor-alpha KW - Silicon Dioxide KW - 7631-86-9 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Humans KW - Tumor Necrosis Factor-alpha -- metabolism KW - Isoenzymes -- metabolism KW - NF-kappa B -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Pulmonary Fibrosis -- chemically induced KW - Silicon Dioxide -- toxicity KW - Air Pollutants, Occupational -- toxicity KW - Pulmonary Fibrosis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71190488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.atitle=Reactive+oxygen+species+and+molecular+mechanism+of+silica-induced+lung+injury.&rft.au=Shi%2C+X%3BDing%2C+M%3BChen%2C+F%3BWang%2C+L%3BRojanasakul%2C+Y%3BVallyathan%2C+V%3BCastranova%2C+V&rft.aulast=Shi&rft.aufirst=X&rft.date=2001-01-01&rft.volume=20+Suppl+1&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational fatalities due to animal-related events. AN - 71182710; 11562015 AB - To better understand the extent of animal-related fatalities in the workplace. This study utilized Census of Fatal Occupational Injuries files from the US Department of Labor for the years 1992-1997 to describe the events surrounding human workplace fatalities associated with animals. During the 6-year time period, 350 workplace deaths could be associated with an animal-related event. Cattle and horses were the animals primarily involved, and workers in the agricultural industry experienced the majority of events. Many deaths involved transportation events, either direct collision with the animal or highway crashes trying to avoid collision with an animal. Exotic animals, primarily elephants and tigers, were responsible for a few deaths. A small number of workers died of a zoonotic infection. We found that approximately 1% of workplace fatalities are associated with an animal-related event. Methods to decrease the frequency of an animal injury are suggested. JF - Wilderness & environmental medicine AU - Langley, R L AU - Hunter, J L AD - North Carolina Department of Health and Human Services, Section of Human Ecology and Epidemiology, Raleigh 27699-1912, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 168 EP - 174 VL - 12 IS - 3 SN - 1080-6032, 1080-6032 KW - Index Medicus KW - Agriculture KW - Animals KW - Age Factors KW - Sex Factors KW - Humans KW - Horses KW - Aged KW - Sports KW - Insects KW - Cause of Death KW - Cattle KW - Adult KW - Veterinarians KW - Middle Aged KW - Birds KW - Adolescent KW - Animals, Zoo KW - United States -- epidemiology KW - Deer KW - Male KW - Female KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71182710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wilderness+%26+environmental+medicine&rft.atitle=Occupational+fatalities+due+to+animal-related+events.&rft.au=Langley%2C+R+L%3BHunter%2C+J+L&rft.aulast=Langley&rft.aufirst=R&rft.date=2001-01-01&rft.volume=12&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Wilderness+%26+environmental+medicine&rft.issn=10806032&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulatory initiatives and framework in the USA: interventional radiology. AN - 71065554; 11487821 AB - Therapeutic procedures using interventional radiology equipment as the imaging tool are often the only available treatment for serious, life-threatening conditions. Many of these procedures require extended periods of radiation exposure often at one location on the patient. As a result, the US Food and Drug Administration (FDA) continues to receive reports of radiation-induced injuries to the skin in patients undergoing some of these therapeutic procedures. The regulatory scheme applicable to interventional radiology equipment in the US is described including federal, state and local aspects, and the impact of professional and non-governmental organisations. Current activities within the FDA and other organisations which have or will affect the use, maintenance and manufacture of interventional radiology equipment are also described. JF - Radiation protection dosimetry AU - Gagne, R M AU - Shope, T B AD - Center for Devices and Radiological Health/FDA, 9200 Corporate Boulevard (HFZ-142), Rockville, Maryland 20850, USA. RMG@CDRH.FDA.Gov Y1 - 2001 PY - 2001 DA - 2001 SP - 13 EP - 18 VL - 94 IS - 1-2 SN - 0144-8420, 0144-8420 KW - Index Medicus KW - United States KW - Radiation Dosage KW - United States Food and Drug Administration KW - Skin -- radiation effects KW - Humans KW - Equipment Safety KW - Radiation Injuries -- etiology KW - Radiography, Interventional -- standards KW - Radiography, Interventional -- instrumentation KW - Radiology, Interventional -- standards KW - Radiography, Interventional -- adverse effects KW - Radiology, Interventional -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71065554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Regulatory+initiatives+and+framework+in+the+USA%3A+interventional+radiology.&rft.au=Gagne%2C+R+M%3BShope%2C+T+B&rft.aulast=Gagne&rft.aufirst=R&rft.date=2001-01-01&rft.volume=94&rft.issue=1-2&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Infections related to breast implants reported to the Food and Drug Administration, 1977-1997. AN - 71064146; 11495100 AB - The FDA has a surveillance system for monitoring adverse events related to medical devices. Infection reports submitted to the FDA by breast implant manufacturers between 1977 and 1997 are characterized. Two cases of death caused by toxic shock syndrome after mammoplasty reported to the FDA are presented. Overall, 1,971 reports with a principal adverse event of infection were reported in this time frame. There was a large increase in the number of reports on infections related to breast implants between 1992 and 1995 due to the publicity and litigation surrounding breast implants. When an organism was identified in the report, the most common organism reported was Staphylococcus sp. Information on the time between the implantation and the onset of the infection or the explantation of the implant was not always reported. However, in reports that did contain this information, there were differences between the length of time to infection onset reported for saline breast implants (earlier) compared to silicone gel breast implants (later). More than half of the reports (56.6%) asserted only that there was an infection and that breast implants were explanted as a result; the remaining reports asserted that infection and other signs, symptoms, or diagnoses had afflicted the patient. JF - Journal of long-term effects of medical implants AU - Brown, S L AU - Hefflin, B AU - Woo, E K AU - Parmentier, C M AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20850, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 1 EP - 12 VL - 11 IS - 1-2 SN - 1050-6934, 1050-6934 KW - Silicone Gels KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Health technology assessment KW - United States Food and Drug Administration KW - Humans KW - Shock, Septic -- etiology KW - United States -- epidemiology KW - Female KW - Bacterial Infections -- etiology KW - Bacterial Infections -- epidemiology KW - Breast Implants -- statistics & numerical data KW - Breast Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71064146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+long-term+effects+of+medical+implants&rft.atitle=Infections+related+to+breast+implants+reported+to+the+Food+and+Drug+Administration%2C+1977-1997.&rft.au=Brown%2C+S+L%3BHefflin%2C+B%3BWoo%2C+E+K%3BParmentier%2C+C+M&rft.aulast=Brown&rft.aufirst=S&rft.date=2001-01-01&rft.volume=11&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+long-term+effects+of+medical+implants&rft.issn=10506934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-06 N1 - Date created - 2001-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimation of the average burst size of Phix174 am3, cs70 for use in mutation assays with transgenic mice. AN - 70958439; 11424186 AB - In mutation assays using transgenic mice, with recoverable vectors such as PhiX174 am3, cs70, mutations originate from two sources: (1) in vivo mutations, that is, mutations that were fixed in the mouse, or (2) ex vivo mutations, that is, mutations that were fixed during recovery or plating. When a bacteriophage infects a bacterium, it multiplies and bursts the cell, releasing a number of phages referred to as the burst size. Our method for distinguishing between in vivo mutations and ex vivo mutations estimates the average number of bursts, the denominator of in vivo mutant frequencies, by dividing the total plaque-forming units (PFU) by the average number of phages in a burst. Herein, we outline a probability model relating observed plaque counts to the burst size and present the statistical method used to estimate the burst size. The average size of a single burst from nonrevertant phages was estimated in eight studies under the conditions of our mutation assay. The average burst size was stable across studies at 182.5 plaques per burst (standard error, 14.25). The probability that a burst is a specific size was approximated by a negative binomial distribution, which implies a Poisson-Pascal distribution for the observed plaque counts. The observed plaque counts were adequately fit by this approximation. Environ. Mol. Mutagen. 37:356-360, 2001 Published 2001 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Delongchamp, R R AU - Valentine, C R AU - Malling, H V AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas, USA. rdelongchamp@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 356 EP - 360 VL - 37 IS - 4 SN - 0893-6692, 0893-6692 KW - Index Medicus KW - Animals KW - Models, Genetic KW - Models, Statistical KW - Mice KW - Poisson Distribution KW - Mutation KW - DNA Mutational Analysis KW - Bacteriophage phi X 174 -- genetics KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70958439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Estimation+of+the+average+burst+size+of+Phix174+am3%2C+cs70+for+use+in+mutation+assays+with+transgenic+mice.&rft.au=Delongchamp%2C+R+R%3BValentine%2C+C+R%3BMalling%2C+H+V&rft.aulast=Delongchamp&rft.aufirst=R&rft.date=2001-01-01&rft.volume=37&rft.issue=4&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Disaster coordination and management: summary and action plans. AN - 70866094; 11367933 AB - Disaster is a collective responsibility requiring coordinated response from all parts of society. This theme focused on coordination and management issues in a diverse range of scenarios. Details of the methods used are provided in the preceding paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. Although the main points developed in Themes 1 and 4 were different from each other (as reported in the Results section), their implementation was similar. Therefore, the chairs of both groups presided over one workshop that resulted in the generation of a set of Action Plans that then were reported to the collective group of all delegates. The main points developed during the presentations and discussions included: (1) the need for evidence-based assessments and planning, (2) the need for a shift in focus to health-sector readiness, (3) empowerment of survivors, (4) provision of relief for the caregivers, (5) address the incentives and disincentives to attain readiness, (6) engage in joint preparation, response, and training, (7) focus on prevention and mitigation of the damage from events, and (8) improve media relations. There exists a need for institutionalization of processes for learning from experiences obtained from disasters. Action plans presented include: (1) creation of an Information and Data Clearinghouse on Disaster Management, (2) identification of incentives and disincentives for readiness and develop strategies and interventions, and (3) act on lessons learned from evidence-based research and practical experience. There is an urgent need to proactively establish coordination and management procedures in advance of any crisis. A number of important insights for improvement in coordination and management during disasters emerged. JF - Prehospital and disaster medicine AU - Eyre, A AU - Fertel, N AU - Fisher, J M AU - Gunn, S W AU - Hampton, D AU - Lederman, B AU - Posner, Z AU - Preobrajensky, V N AU - Rebonato, M AU - Riboni, V AU - Rodriguez, D AU - Shih, C L AU - Yamamoto, Y AD - Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Washington, DC, USA. PY - 2001 SP - 22 EP - 25 VL - 16 IS - 1 SN - 1049-023X, 1049-023X KW - Health technology assessment KW - Evidence-Based Medicine KW - Primary Prevention -- organization & administration KW - Public Relations KW - Humans KW - Power (Psychology) KW - Health Services Research KW - Databases, Factual KW - Survivors KW - Program Development -- methods KW - Mass Media KW - Disaster Planning -- organization & administration KW - Continuity of Patient Care -- organization & administration KW - Health Planning -- organization & administration KW - Needs Assessment -- organization & administration KW - Interinstitutional Relations KW - Relief Work -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70866094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prehospital+and+disaster+medicine&rft.atitle=Disaster+coordination+and+management%3A+summary+and+action+plans.&rft.au=Eyre%2C+A%3BFertel%2C+N%3BFisher%2C+J+M%3BGunn%2C+S+W%3BHampton%2C+D%3BLederman%2C+B%3BPosner%2C+Z%3BPreobrajensky%2C+V+N%3BRebonato%2C+M%3BRiboni%2C+V%3BRodriguez%2C+D%3BShih%2C+C+L%3BYamamoto%2C+Y&rft.aulast=Eyre&rft.aufirst=A&rft.date=2001-01-01&rft.volume=16&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Prehospital+and+disaster+medicine&rft.issn=1049023X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic drug monitoring in methadone maintenance: choosing a matrix. AN - 70792654; 11318398 AB - Methadone maintenance is the premier pharmacological treatment for opioid addiction, but it is rarely informed by evidence-based practice guidelines for dosage monitoring and adjustment. Such guidelines are crucial because the pharmacokinetics of methadone vary greatly among patients, and this variation may account for differences in treatment outcome. We review the pharmacokinetics of methadone and factors that may alter it (including drug interactions, disease states, and idiosyncratic differences among patients). Also reviewed are prospects for therapeutic drug monitoring (TDM) of methadone in plasma, urine, sweat, and saliva. Due to its ease of collection and its presumed representation of the bioavailable free-fraction of methadone, saliva may be a promising matrix. However, saliva methadone concentrations are influenced by salivary pH, and future studies are needed to determine how to control for that. Administrative, medical, and social implications of methadone TDM are briefly discussed. JF - Journal of addictive diseases AU - Moolchan, E T AU - Umbricht, A AU - Epstein, D AD - Department of Health and Human Services, National Institute of Health, National Institute of Drug Abuse, Baltimore, MD 21224, USA. emoolcha@intra.nida.nih.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 55 EP - 73 VL - 20 IS - 2 SN - 1055-0887, 1055-0887 KW - Narcotics KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - CYP3A protein, human KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Drug Interactions KW - Sweat -- metabolism KW - Mixed Function Oxygenases -- metabolism KW - Half-Life KW - Humans KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Saliva -- metabolism KW - Male KW - Female KW - Methadone -- therapeutic use KW - Drug Monitoring KW - Narcotics -- therapeutic use KW - Narcotics -- metabolism KW - Methadone -- pharmacokinetics KW - Opioid-Related Disorders -- rehabilitation KW - Narcotics -- pharmacokinetics KW - Methadone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70792654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Therapeutic+drug+monitoring+in+methadone+maintenance%3A+choosing+a+matrix.&rft.au=Moolchan%2C+E+T%3BUmbricht%2C+A%3BEpstein%2C+D&rft.aulast=Moolchan&rft.aufirst=E&rft.date=2001-01-01&rft.volume=20&rft.issue=2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats. AN - 70785325; 11317337 AB - N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) is the proximate carcinogenic metabolite of the powerful rat liver carcinogen 2-acetylaminofluorene. In this study, transgenic Big Blue(R) rats were used to examine the relationship between in vivo mutagenicity and DNA adduct formation by N-OH-AAF in the target liver compared with that in nontarget tissues. Male rats were given one, two, or four doses of 25 mg N-OH-AAF/kg body weight by i.p. injection at 4-day intervals, and groups of treated and control rats were euthanized up to 10 weeks after beginning the dosing. Mutant frequencies were measured in the spleen lymphocyte hprt gene, and lacI mutant frequencies were determined in the liver and spleen lymphocytes. At 6 weeks after beginning the dosing, the hprt mutant frequency in spleen lymphocytes from the four-dose group was 16.5 x 10(-6) compared with 3.2 x 10(-6) in control animals. Also at 6 weeks, rats given one, two, or four doses of N-OH-AAF had lacI mutant frequencies in the liver of 97.6, 155.6, and 406.8 x 10(-6), respectively, compared with a control frequency of 25.7 x 10(-6); rats given four doses had lacI mutant frequencies in spleen lymphocytes of 55.8 x 10(-6) compared with a control frequency of 20.4 x 10(-6). Additional rats were evaluated for DNA adduct formation in the liver, spleen lymphocytes, and bone marrow by (32)P-postlabeling. Adduct analysis was conducted 1 day after one, two, and four treatments with N-OH-AAF, 5 days after one treatment, and 9 days after two treatments. N-(Deoxyguanosin-8-yl)-2-aminofluorene was the major DNA adduct identified in all the tissues examined. Adduct concentrations increased with total dose to maximum values in samples taken 1 day after two doses, and remained essentially the same after four doses. In samples taken after four doses, adduct levels were 103, 28, and 7 fmol/microg of DNA in liver, spleen lymphocytes, and bone marrow, respectively. The results indicate that the extent of both DNA adduct formation and mutant induction correlates with the organ specificity for N-OH-AAF carcinogenesis in the rat. Environ. Mol. Mutagen. 37:195-202, 2001. Published 2001 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Chen, T AU - Mittelstaedt, R A AU - Aidoo, A AU - Hamilton, L P AU - Beland, F A AU - Casciano, D A AU - Heflich, R H AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. TChen@NCTR.FDA.GOV Y1 - 2001 PY - 2001 DA - 2001 SP - 195 EP - 202 VL - 37 IS - 3 SN - 0893-6692, 0893-6692 KW - Bacterial Proteins KW - 0 KW - DNA Adducts KW - Escherichia coli Proteins KW - Lac Repressors KW - Repressor Proteins KW - Hydroxyacetylaminofluorene KW - 53-95-2 KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Index Medicus KW - Animals KW - Spleen -- physiology KW - Spleen -- cytology KW - Organ Specificity KW - Animals, Genetically Modified KW - Liver -- physiology KW - Rats KW - Rats, Inbred F344 KW - Liver -- drug effects KW - Spleen -- drug effects KW - Lymphocytes -- drug effects KW - Male KW - Hypoxanthine Phosphoribosyltransferase -- drug effects KW - Bacterial Proteins -- drug effects KW - Bacterial Proteins -- genetics KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Repressor Proteins -- drug effects KW - Repressor Proteins -- genetics KW - Mutation KW - Hydroxyacetylaminofluorene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70785325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Comparison+of+hprt+and+lacI+mutant+frequency+with+DNA+adduct+formation+in+N-hydroxy-2-acetylaminofluorene-treated+Big+Blue+rats.&rft.au=Chen%2C+T%3BMittelstaedt%2C+R+A%3BAidoo%2C+A%3BHamilton%2C+L+P%3BBeland%2C+F+A%3BCasciano%2C+D+A%3BHeflich%2C+R+H&rft.aulast=Chen&rft.aufirst=T&rft.date=2001-01-01&rft.volume=37&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of amplified ELISA and mouse bioassay procedures for determination of botulinal toxins A, B, E, and F. AN - 70687642; 11234855 AB - The amplified enzyme-linked immunosorbent assay (amp-ELISA) was compared to the mouse bioassay for determination of botulinal neurotoxin types A, B, E, and F. Twelve different toxin-producing type A, 13 proteolytic type B, 9 nonproteolytic type B, 16 type E, 8 proteolytic type F, 5 nonproteolytic type F, and 6 nontoxigenic clostridial strains were tested. The cultures were inoculated into cooked meat medium (CMM) and tryptone-peptone-glucose-yeast extract (TPGY) medium, incubated for 5 days, and then examined for biological toxicity in mice and amp-ELISA endpoints. The amp-ELISA was less sensitive in detecting toxins produced by nonproteolytic than proteolytic strains of type B and F organisms. All of the toxin-producing strains tested were positive by the AOAC method and the amp-ELISA in either undiluted TPGY or CMM culture fluids regardless of mouse toxicity level, source, or strain. Cross-reactivity was observed between some but not all of the botulinal strains tested. None of the nontoxigenic strains were positive by the amp-ELISA. Purified botulinal toxins were also assayed using these 2 methods. The sensitivity of the amp-ELISA using purified neurotoxins was about 0.1 ng/mL for types A, B, and E and about 1.0 ng/mL for type F. JF - Journal of AOAC International AU - Ferreira, J L AD - US Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309, USA. PY - 2001 SP - 85 EP - 88 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Culture Media KW - 0 KW - botulinum toxin type D KW - botulinum toxin type F KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Animals KW - Reference Standards KW - Biological Assay KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Culture Media -- analysis KW - Botulinum Toxins, Type A -- analysis KW - Cross Reactions KW - Botulinum Toxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70687642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Comparison+of+amplified+ELISA+and+mouse+bioassay+procedures+for+determination+of+botulinal+toxins+A%2C+B%2C+E%2C+and+F.&rft.au=Ferreira%2C+J+L&rft.aulast=Ferreira&rft.aufirst=J&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiclass multiresidue methods for organic compounds. AN - 70677471; 11234827 JF - Journal of AOAC International AU - Parfitt, C H AU - AOAC International. Committee on Residues and Related Topics AD - US Food and Drug Administration, Division of Field Science, Rockville, MD 20857, USA. cparfitt@ora.fda.gov ; AOAC International. Committee on Residues and Related Topics PY - 2001 SP - 239 EP - 240 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Pesticide Residues KW - 0 KW - Index Medicus KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Pesticide Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70677471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Multiclass+multiresidue+methods+for+organic+compounds.&rft.au=Parfitt%2C+C+H%3BAOAC+International.+Committee+on+Residues+and+Related+Topics&rft.aulast=Parfitt&rft.aufirst=C&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mycotoxins. AN - 70676814; 11234813 JF - Journal of AOAC International AU - Trucksess, M W AU - AOAC International. Committee on Natural Toxins and Food Allergens AD - US Food and Drug Administration, Washington, DC 20204, USA. mtruckse@cfsan.fda.gov ; AOAC International. Committee on Natural Toxins and Food Allergens PY - 2001 SP - 202 EP - 211 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Mycotoxins KW - 0 KW - Index Medicus KW - Guidelines as Topic KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70676814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Mycotoxins.&rft.au=Trucksess%2C+M+W%3BAOAC+International.+Committee+on+Natural+Toxins+and+Food+Allergens&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Assuring the integrity of olive oil products. AN - 70676778; 11234806 JF - Journal of AOAC International AU - Firestone, D PY - 2001 SP - 176 EP - 180 VL - 84 IS - 1 KW - Dietary Fats, Unsaturated KW - 0 KW - Olive Oil KW - Plant Oils KW - Index Medicus KW - United States KW - Brassica -- poisoning KW - Food Labeling KW - United States Food and Drug Administration KW - Food Contamination KW - Foodborne Diseases -- prevention & control KW - Awards and Prizes KW - Food Inspection KW - Dietary Fats, Unsaturated -- analysis KW - Plant Oils -- analysis KW - Dietary Fats, Unsaturated -- standards KW - Plant Oils -- standards KW - Food -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70676778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Assuring+the+integrity+of+olive+oil+products.&rft.au=Firestone%2C+D&rft.aulast=Firestone&rft.aufirst=D&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Food microbiology--non dairy. AN - 70676368; 11234830 JF - Journal of AOAC International AU - Andrews, W H AU - AOAC International. Committee on Microbiology and Extraneous Materials AD - US Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA. wallace.andrews@cfsan.fda.gov ; AOAC International. Committee on Microbiology and Extraneous Materials PY - 2001 SP - 243 EP - 250 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Index Medicus KW - Bacteriological Techniques -- methods KW - Guidelines as Topic KW - Food Analysis -- methods KW - Bacteria -- genetics KW - Food Microbiology -- standards KW - Bacteria -- isolation & purification KW - Bacteria -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70676368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Food+microbiology--non+dairy.&rft.au=Andrews%2C+W+H%3BAOAC+International.+Committee+on+Microbiology+and+Extraneous+Materials&rft.aulast=Andrews&rft.aufirst=W&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fats and oils. AN - 70676288; 11234818 JF - Journal of AOAC International AU - Firestone, D AU - Yurawecz, M P AU - AOAC International. Committee on Food Nutrition AD - US Food and Drug Administration, Washington, DC 20204, USA. dbfirestone@juno.com ; AOAC International. Committee on Food Nutrition PY - 2001 SP - 219 EP - 222 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Dietary Fats KW - 0 KW - Oils KW - Index Medicus KW - Animals KW - Humans KW - Food Contamination KW - Food Analysis -- methods KW - Dietary Fats -- analysis KW - Oils -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70676288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Fats+and+oils.&rft.au=Firestone%2C+D%3BYurawecz%2C+M+P%3BAOAC+International.+Committee+on+Food+Nutrition&rft.aulast=Firestone&rft.aufirst=D&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radioactivity. AN - 70663438; 11234825 JF - Journal of AOAC International AU - Baratta, E AU - AOAC International. Committee on Residues and Related Topics AD - US Food and Drug Administration, Winchester Engineering and Analytical Center, MA 01890, USA. ebaratta@ora.fda.gov ; AOAC International. Committee on Residues and Related Topics PY - 2001 SP - 236 EP - 237 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Cesium Radioisotopes KW - 0 KW - Iodine Radioisotopes KW - Radioisotopes KW - Index Medicus KW - Cesium Radioisotopes -- analysis KW - Iodine Radioisotopes -- analysis KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Food Contamination, Radioactive KW - Radioisotopes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70663438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Radioactivity.&rft.au=Baratta%2C+E%3BAOAC+International.+Committee+on+Residues+and+Related+Topics&rft.aulast=Baratta&rft.aufirst=E&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rappaport-Vassiliadis medium for recovery of Salmonella spp. from low microbial load foods: collaborative study. AN - 70661420; 11234854 AB - Twenty-three laboratories participated in a collaborative study to compare the relative effectiveness of Rappaport-Vassiliadis (RV) medium incubated at 42 degrees C, selenite cystine (SC) broth (35 degrees C), and tetrathionate (TT) broth (35 and 43 degrees C) for recovery of Salmonella from the following foods with a low microbial load: dried egg yolk, dry active yeast, ground black pepper, guar gum, and instant nonfat dry milk. For dry active yeast, lauryl tryptose (LT) broth, incubated at 35 degrees C, was used instead of SC broth. All of the foods were artificially inoculated with single Salmonella serovars, that had been lyophilized before inoculation, at high and low target levels of 0.4 and 0.04 colony forming units/g food, respectively. For analysis of 870 test portions, representing all of the foods except yeast, 249 Salmonella-positive test portions were detected by RV medium, 265 by TT broth (43 degrees C), 268 by TT broth (35 degrees C), and 269 by SC broth (35 degrees C). For analysis of 225 test portions of yeast, 79 Salmonella-positive test portions were detected by RV medium, 79 by TT broth (43 degrees C), 84 by TT broth (35 degrees C), and 68 by LT broth (35 degrees C). RV medium was comparable to, or even more effective than, the other selective enrichments for recovery of Salmonella from all of the foods except guar gum. It is recommended that RV (42 degrees C) and TT (35 degrees C) be used with foods that have a low microbial load, except for guar gum for which SC (35 degrees C) and TT (35 degrees C) are recommended. JF - Journal of AOAC International AU - Hammack, T S AU - Amaguaña, R M AU - Andrews, W H AU - Lerner, I AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA. thomas.hammack@cfsan.fda.gov PY - 2001 SP - 65 EP - 83 VL - 84 IS - 1 SN - 1060-3271, 1060-3271 KW - Culture Media KW - 0 KW - Galactans KW - Indicators and Reagents KW - Mannans KW - Plant Gums KW - guar gum KW - E89I1637KE KW - Index Medicus KW - Yeast, Dried -- analysis KW - Mannans -- analysis KW - Animals KW - Transportation KW - Spices -- microbiology KW - Eggs -- microbiology KW - Milk -- microbiology KW - Galactans -- analysis KW - Food Microbiology KW - Salmonella -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70661420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Rappaport-Vassiliadis+medium+for+recovery+of+Salmonella+spp.+from+low+microbial+load+foods%3A+collaborative+study.&rft.au=Hammack%2C+T+S%3BAmagua%C3%B1a%2C+R+M%3BAndrews%2C+W+H%3BLerner%2C+I&rft.aulast=Hammack&rft.aufirst=T&rft.date=2001-01-01&rft.volume=84&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J AOAC Int 2001 May-Jun;84(3):49A N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo. AN - 70619879; 11170513 AB - Riddelliine is a representative naturally occurring genotoxic pyrrolizidine alkaloid. We have studied the mechanism by which riddelliine induces hepatocellular tumors in vivo. Metabolism of riddelliine by liver microsomes of F344 female rats generated riddelliine N-oxide and dehydroretronecine (DHR) as major metabolites. Metabolism was enhanced when liver microsomes from phenobarbital-treated rats were used. Metabolism in the presence of calf thymus DNA resulted in eight DNA adducts that were identical to those obtained from the reaction of DHR with calf thymus DNA. Two of these adducts were identified as DHR-modified 7-deoxyguanosin-N(2)-yl epimers (DHR-3'-dGMP); the other six were DHR-derived DNA adducts, but their structures were not characterized. A similar DNA adduct profile was detected in the livers of female F344 rats fed riddelliine, and a dose-response relationship was obtained for the level of the total (eight) DHR-derived DNA adducts and the level of the DHR-3'-dGMP adducts. These results suggest that riddelliine induces liver tumors in rats through a genotoxic mechanism and the eight DHR-derived DNA adducts are likely to contribute to liver tumor development. JF - Chemical research in toxicology AU - Yang, Y C AU - Yan, J AU - Doerge, D R AU - Chan, P C AU - Fu, P P AU - Chou, M W AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 101 EP - 109 VL - 14 IS - 1 SN - 0893-228X, 0893-228X KW - Carcinogens KW - 0 KW - DNA Adducts KW - Phosphorus Radioisotopes KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - Monocrotaline KW - 73077K8HYV KW - riddelliine N-oxide KW - 75056-11-0 KW - DNA KW - 9007-49-2 KW - dehydroretronecine KW - QG6MWR17OH KW - Index Medicus KW - Animals KW - DNA -- metabolism KW - Microsomes, Liver -- metabolism KW - Liver -- metabolism KW - DNA -- drug effects KW - Rats KW - Rats, Inbred F344 KW - Cattle KW - Biotransformation KW - Liver -- drug effects KW - Isotope Labeling -- methods KW - Chromatography, High Pressure Liquid -- methods KW - Female KW - DNA Adducts -- biosynthesis KW - Monocrotaline -- metabolism KW - Pyrrolizidine Alkaloids -- pharmacokinetics KW - Carcinogens -- metabolism KW - Monocrotaline -- pharmacokinetics KW - Monocrotaline -- analogs & derivatives KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- toxicity KW - Liver Neoplasms, Experimental -- chemically induced KW - Pyrrolizidine Alkaloids -- toxicity KW - Pyrrolizidine Alkaloids -- metabolism KW - Monocrotaline -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70619879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Metabolic+activation+of+the+tumorigenic+pyrrolizidine+alkaloid%2C+riddelliine%2C+leading+to+DNA+adduct+formation+in+vivo.&rft.au=Yang%2C+Y+C%3BYan%2C+J%3BDoerge%2C+D+R%3BChan%2C+P+C%3BFu%2C+P+P%3BChou%2C+M+W&rft.aulast=Yang&rft.aufirst=Y&rft.date=2001-01-01&rft.volume=14&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cercopithecine herpesvirus 1 (B virus) infection resulting from ocular exposure. AN - 70603131; 11202026 JF - Applied occupational and environmental hygiene AU - National Institute for Occupational Safety and Health AD - National Institute for Occupational Safety and Health Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 32 EP - 34 VL - 16 IS - 1 SN - 1047-322X, 1047-322X KW - Index Medicus KW - Eye -- virology KW - Animals KW - Humans KW - Housing, Animal KW - Adult KW - Animals, Laboratory KW - Female KW - Occupational Exposure KW - Herpesviridae Infections -- transmission KW - Eye Protective Devices KW - Herpesviridae Infections -- veterinary KW - Macaca mulatta -- virology KW - Herpesvirus 1, Cercopithecine -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70603131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Cercopithecine+herpesvirus+1+%28B+virus%29+infection+resulting+from+ocular+exposure.&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2001-01-01&rft.volume=16&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Renovation of contaminated building materials at a facility serving pediatric cancer outpatients. AN - 70602887; 11202025 JF - Applied occupational and environmental hygiene AU - Weber, A AU - Page, E AD - Division of Surveillance, Hazard Evaluations and Field Studies of NIOSH, Cincinnati, OH 45226, USA. Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 2 EP - 31 VL - 16 IS - 1 SN - 1047-322X, 1047-322X KW - Water KW - 059QF0KO0R KW - Index Medicus KW - United States KW - Environmental Monitoring KW - Occupational Health KW - Pediatrics KW - Humans KW - Child KW - Stachybotrys -- isolation & purification KW - Neoplasms -- therapy KW - National Institute for Occupational Safety and Health (U.S.) KW - Sick Building Syndrome KW - Mycotoxicosis -- prevention & control KW - Mycotoxicosis -- etiology KW - Facility Design and Construction KW - Ambulatory Care Facilities KW - Manufactured Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=Renovation+of+contaminated+building+materials+at+a+facility+serving+pediatric+cancer+outpatients.&rft.au=Weber%2C+A%3BPage%2C+E&rft.aulast=Weber&rft.aufirst=A&rft.date=2001-01-01&rft.volume=16&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxins directed at interleukin-4 receptors as therapy for human brain tumors. AN - 70599466; 11217365 JF - Methods in molecular biology (Clifton, N.J.) AU - Puri, R K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 155 EP - 176 VL - 166 SN - 1064-3745, 1064-3745 KW - Antineoplastic Agents KW - 0 KW - Bacterial Toxins KW - Exotoxins KW - Immunotoxins KW - Neoplasm Proteins KW - Receptors, Interleukin-4 KW - Virulence Factors KW - interleukin 4 (38-37)-PE38KDEL KW - Interleukin-4 KW - 207137-56-2 KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Neuroblastoma -- pathology KW - Injections, Intraperitoneal KW - Animals KW - Injections, Intralesional KW - Macaca fascicularis KW - Injections, Intravenous KW - Guinea Pigs KW - Humans KW - Mice, Nude KW - Mice KW - Glioblastoma -- drug therapy KW - Neuroblastoma -- metabolism KW - Rats KW - Neuroblastoma -- drug therapy KW - Glioblastoma -- pathology KW - Clinical Trials, Phase I as Topic KW - Injections, Spinal KW - Glioblastoma -- metabolism KW - Treatment Outcome KW - Xenograft Model Antitumor Assays KW - Protein Structure, Tertiary KW - Tumor Stem Cell Assay KW - Neoplasm Proteins -- drug effects KW - Brain Neoplasms -- pathology KW - Brain Neoplasms -- metabolism KW - Neoplasm Proteins -- chemistry KW - Immunotoxins -- administration & dosage KW - Receptors, Interleukin-4 -- chemistry KW - Glioma -- pathology KW - Brain Neoplasms -- drug therapy KW - Glioma -- drug therapy KW - Immunotoxins -- therapeutic use KW - Immunotoxins -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Exotoxins -- therapeutic use KW - Glioma -- metabolism KW - Interleukin-4 -- physiology KW - Antineoplastic Agents -- pharmacology KW - Receptors, Interleukin-4 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70599466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Cytotoxins+directed+at+interleukin-4+receptors+as+therapy+for+human+brain+tumors.&rft.au=Puri%2C+R+K&rft.aulast=Puri&rft.aufirst=R&rft.date=2001-01-01&rft.volume=166&rft.issue=&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-21 N1 - Date created - 2001-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Supermarket tampering: cocaine detected in syringes and in fruit. AN - 70590055; 11210900 AB - Product tampering, as detailed by the Federal Anti-Tampering Act of 1983 (1), is a felony punishable by both fine and imprisonment. The rationale for product tampering ranges from pranks and attention seeking acts to extortion, terrorism, and homicide. One such case submitted for analysis involved four medical syringes found in a supermarket and suspected of being used to tamper with various products. One of the syringes was found piercing a pear while the other three syringes were found with needles exposed in other parts of the supermarket. Microscopic analysis was used to collect residue from the syringe barrels and the pear. A multidiscipline approach involving SLM, PLM, including microchemical analysis, FTIR, and GC/MS analyses, performed on the residual liquid found in the syringe barrels and in the suspect pear, confirmed the presence of cocaine. This multidisciplinary approach is often necessary when there is a possible health risk to the public and rapid response is important. With this approach, it was quickly determined which drugs or poisons were used in this tampering. JF - Journal of forensic sciences AU - Tomlinson, J A AU - Crowe, J B AU - Ranieri, N AU - Kindig, J P AU - Platek, S F AD - Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, USA. Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 144 EP - 146 VL - 46 IS - 1 SN - 0022-1198, 0022-1198 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Public Health KW - Humans KW - Forensic Medicine -- methods KW - Cocaine -- analysis KW - Dopamine Uptake Inhibitors -- analysis KW - Crime KW - Food Contamination KW - Syringes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70590055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+forensic+sciences&rft.atitle=Supermarket+tampering%3A+cocaine+detected+in+syringes+and+in+fruit.&rft.au=Tomlinson%2C+J+A%3BCrowe%2C+J+B%3BRanieri%2C+N%3BKindig%2C+J+P%3BPlatek%2C+S+F&rft.aulast=Tomlinson&rft.aufirst=J&rft.date=2001-01-01&rft.volume=46&rft.issue=1&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Journal+of+forensic+sciences&rft.issn=00221198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Volatile and non-volatile compounds in irradiated semi-rigid crystalline poly(ethylene terephthalate) polymers. AN - 70588010; 11212551 AB - In this study two different semi-rigid crystalline and oriented polyethylene terephthalate materials were used and were irradiated at 25-kGy dose at room temperature by using a caesium137 radiator. Volatile and non-volatile compounds present in the irradiated materials were identified and quantified. The qualitative results obtained from HS/GC/TCD/FID analysis at room temperature showed volatiles could not be identified. The HS/GC/MSD analysis performed at 106 degrees C showed that the irradiation generated 668-742 micrograms/kg formic acid, 868-922 micrograms/kg acetic acid, 17-32 micrograms/kg 1,3-dioxolane, and 47-71 micrograms/kg 2-methyl-1, 3-dioxolane based on PET weight. The results obtained from the thermal desorption and GC/MSD performed at 200 degrees C showed that 10-12 mg/kg acetaldehyde, 479-975 micrograms/kg 1,3-dioxolane, and 6.6-11.2 mg/kg methyl-1, 3-dioxolane were detected after irradiation. The concentrations of the two dioxolanes found from thermal desorption were much higher than those observed in the HS, although formic and acetic acids were not detected. It is possible that the formic and acetic acids produced by irradiation underwent further reactions with ethylene glycol during thermal desorption to form the dioxolanes. The soluble solid extracted from various PET specimens before and after irradiation were in a range of 0.67-0.78%. PET cyclic trimer is the major component and is present at 0.41-0.50%, accounting for more than 50% of the percent total solid in PET. Statistically, irradiation did not increase the soluble solid and cyclic trimer. The overall results suggest that 25-kGy irradiation had a significant effect on increasing the volatile but not the non-volatile compounds detected in the PET specimens. JF - Food additives and contaminants AU - Komolprasert, V AU - McNeal, T P AU - Agrawal, A AU - Adhikari, C AU - Thayer, D W AD - National Center for Food Safety and Technology/Illinois Institute of Technology, USA. vkomolpr@cfsan.fda.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 89 EP - 101 VL - 18 IS - 1 SN - 0265-203X, 0265-203X KW - Polyethylene Terephthalates KW - 0 KW - Index Medicus KW - Mass Spectrometry KW - Analysis of Variance KW - Food Irradiation KW - Chromatography, High Pressure Liquid KW - Chromatography, Gas -- methods KW - Food Packaging -- standards KW - Food Contamination -- analysis KW - Polyethylene Terephthalates -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70588010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+and+contaminants&rft.atitle=Volatile+and+non-volatile+compounds+in+irradiated+semi-rigid+crystalline+poly%28ethylene+terephthalate%29+polymers.&rft.au=Komolprasert%2C+V%3BMcNeal%2C+T+P%3BAgrawal%2C+A%3BAdhikari%2C+C%3BThayer%2C+D+W&rft.aulast=Komolprasert&rft.aufirst=V&rft.date=2001-01-01&rft.volume=18&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Food+additives+and+contaminants&rft.issn=0265203X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Surface plasmon resonance analysis of staphylococcal enterotoxin B in food. AN - 70586925; 11198439 AB - Surface plasmon resonance (SPR) biosensors are electro-optical instruments used for analyzing real-time protein-protein interactions. This work evaluates an SPR biosensor (Biacore 3000) in the detection of staphylococcal enterotoxin B (SEB) in foods. A sandwich SPR immunosensor involving two antibodies was used. The capturing antibody, bound covalently to the surface of the biosensor chip, performs the initial binding of the antigen and a second antibody binds to the captured antigen. The second antibody makes antigen verification possible and amplifies the signal. Pure SEB as well as SEB in spiked foods (milk and meat) were detected with little interference from the food matrix. In the control experiments with uncontaminated food samples no significant signal was detected. The SPR biosensor assay detects SEB at approximately10 ng/ml rapidly, with initial binding within 2 min. The entire measurement cycle (including washing and chip regeneration) may take 5 min using one antibody or 8 min using two antibodies. These results suggest that the SPR biosensor may be a useful tool for real-time analysis of toxin in foods. JF - Journal of food protection AU - Rasooly, A AD - Division of Microbiological Studies, U.S. Food and Drug Administration, Washington, D.C. 20204, USA. axr@vm.cfsan.fda.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 37 EP - 43 VL - 64 IS - 1 SN - 0362-028X, 0362-028X KW - Antibodies, Bacterial KW - 0 KW - Enterotoxins KW - enterotoxin B, staphylococcal KW - 39424-53-8 KW - Index Medicus KW - Sensitivity and Specificity KW - Food Analysis -- methods KW - Animals KW - Food Microbiology KW - Staphylococcal Food Poisoning -- prevention & control KW - Staphylococcal Food Poisoning -- microbiology KW - Meat -- microbiology KW - Time Factors KW - Surface Plasmon Resonance -- methods KW - Staphylococcus aureus -- isolation & purification KW - Enterotoxins -- isolation & purification KW - Food Contamination -- analysis KW - Enterotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70586925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Surface+plasmon+resonance+analysis+of+staphylococcal+enterotoxin+B+in+food.&rft.au=Rasooly%2C+A&rft.aulast=Rasooly&rft.aufirst=A&rft.date=2001-01-01&rft.volume=64&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Review of studies establishing the aging male spontaneously hypertensive rat as a detector and quantifier of the kidney toxicity of radiocontrast media and other chemicals. AN - 70576648; 11176262 AB - There is a need for practical and sensitive preclinical tests for detecting the kidney toxicity of chemicals. The spontaneously hypertensive rat (SHR), as it ages, develops renal and cardiovascular changes similar to those considered as human risk factors for radiocontrast-induced renal damage. Age, male gender, and uncontrolled hypertension make these animals susceptible to the volume and osmolality of the administered contrast agent and the effect of repeated contrast administration after a brief interval. This article reviews studies in which the role of these and other factors were evaluated to validate the male SHR as a small animal model for renal damage induced by contrast and other agents. Systolic blood pressure was measured with a tail cuff before and after the administration of the experimental substances, and the left kidney and heart were studied histologically to determine the influence of age, dose of contrast repeated at a short interval, gender and strain, the role of the sympathetic adrenergic nervous system, osmolality, and apoptosis. As the animals aged and the systolic blood pressure remained elevated, the animals developed progressive renal lesions that worsened after the administration of contrast. The most advanced renal lesions occurred in adult male SHRs that received two doses of contrast 6 hours apart. Female SHR rats and male Wistar Kyoto rats showed no effect or only minimal changes in heart and kidneys after the administration of contrast compared with age-matched male SHRs. Adrenergic blockade allowed only a small elevation in systolic blood pressure after contrast administration but did not protect the kidneys against renal damage by contrast. Hypaque, Omnipaque, and mannitol caused renal damage in proportion to their osmolality. Apoptosis with Hypaque, Omnipaque, and mannitol was observed in the kidney and heart. The results indicate that the aging male SHR develops spontaneous renal lesions that progress with age, increasing the susceptibility to the renal-damaging effects of contrast. Thus, the aging male SHR provides a laboratory tool for detecting the risk of renal damage of new contrast media as well as other pharmaceuticals and assessing methods to protect the kidneys and possible mechanisms of renal damage. JF - Investigative radiology AU - Duarte, C G AU - Zhang, J AU - Ellis, S AD - Division of Cardio-Renal Drug Products, U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Laurel, Maryland 20857, USA. duarte@cder.fda.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 56 EP - 63 VL - 36 IS - 1 SN - 0020-9996, 0020-9996 KW - Contrast Media KW - 0 KW - Diatrizoate Meglumine KW - 3X9MR4N98U KW - Iohexol KW - 4419T9MX03 KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Rats KW - Osmolar Concentration KW - Animals KW - Age Factors KW - Rats, Inbred WKY KW - Rats, Inbred SHR KW - Sex Factors KW - Apoptosis -- drug effects KW - Aging KW - Blood Pressure -- drug effects KW - Creatinine -- blood KW - Male KW - Female KW - Contrast Media -- adverse effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Iohexol -- adverse effects KW - Diatrizoate Meglumine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70576648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=Review+of+studies+establishing+the+aging+male+spontaneously+hypertensive+rat+as+a+detector+and+quantifier+of+the+kidney+toxicity+of+radiocontrast+media+and+other+chemicals.&rft.au=Duarte%2C+C+G%3BZhang%2C+J%3BEllis%2C+S&rft.aulast=Duarte&rft.aufirst=C&rft.date=2001-01-01&rft.volume=36&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of occupational exposures to hepatitis C virus: current practice and controversies. AN - 70575876; 11198026 AB - Unlike hepatitis B virus and human immunodeficiency virus, there currently are no immunization or chemoprophylactic interventions available to prevent infection after an occupational exposure to hepatitis C virus (HCV). A "Reality Check" session was held at the 4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections to gather information on current practices related to management of occupational exposures to HCV, generate discussion on controversial issues, and identify areas for future research. Infection control professionals in attendance were knowledgeable in most issues addressed regarding the management of occupational exposures to HCV. Areas of controversy included the use of antiviral therapy early in the course of HCV infection and the appropriate administrative management of an HCV-infected healthcare worker. JF - Infection control and hospital epidemiology AU - Alvarado-Ramy, F AU - Alter, M J AU - Bower, W AU - Henderson, D K AU - Sohn, A H AU - Sinkowitz-Cochran, R L AU - Jarvis, W R AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia 30333, USA. Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 53 EP - 55 VL - 22 IS - 1 SN - 0899-823X, 0899-823X KW - Index Medicus KW - Nursing KW - Personnel, Hospital KW - Guideline Adherence KW - Humans KW - Practice Guidelines as Topic KW - Occupational Exposure KW - Hepacivirus -- pathogenicity KW - Hepatitis C -- transmission KW - Infection Control -- methods KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+control+and+hospital+epidemiology&rft.atitle=Management+of+occupational+exposures+to+hepatitis+C+virus%3A+current+practice+and+controversies.&rft.au=Alvarado-Ramy%2C+F%3BAlter%2C+M+J%3BBower%2C+W%3BHenderson%2C+D+K%3BSohn%2C+A+H%3BSinkowitz-Cochran%2C+R+L%3BJarvis%2C+W+R&rft.aulast=Alvarado-Ramy&rft.aufirst=F&rft.date=2001-01-01&rft.volume=22&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Infection+control+and+hospital+epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health and safety concerns of zoo and aquarium workers and animal control officers. AN - 70568014; 11107232 AB - There are 183 zoos and aquariums accredited by the American Zoo and Aquarium Association and scores of smaller, nonaccredited zoos in the U.S. Thousands of individuals work at these zoos in many different roles. Likewise, most counties and many larger cities employ animal control officers and have animal shelters. The authors discuss the numerous hazards encountered by animal control officers as well as employees of zoo and aquarium facilities. Suggested protocols for ensuring a safe workplace are presented. However, a thorough industrial hygiene and safety inspection should be performed on a regular basis, as additional protocols may be needed periodically. JF - Occupational medicine (Philadelphia, Pa.) AU - Langley, R AU - Loomis, M AD - Department of Health and Human Services, Raleigh, NC 27699-1912, USA. PY - 2001 SP - 163 EP - 182 VL - 16 IS - 1 SN - 0885-114X, 0885-114X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Hypersensitivity -- epidemiology KW - Animals KW - Pregnancy Complications -- etiology KW - Humans KW - Safety Management KW - Hazardous Substances -- toxicity KW - Pregnancy KW - Pregnancy Complications -- epidemiology KW - Housing, Animal KW - Hypersensitivity -- etiology KW - Occupational Diseases -- epidemiology KW - Zoonoses -- epidemiology KW - Female KW - Zoonoses -- transmission KW - Radiation, Ionizing KW - Occupational Exposure KW - Occupational Health KW - Accidents, Occupational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70568014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Health+and+safety+concerns+of+zoo+and+aquarium+workers+and+animal+control+officers.&rft.au=Langley%2C+R%3BLoomis%2C+M&rft.aulast=Langley&rft.aufirst=R&rft.date=2001-01-01&rft.volume=16&rft.issue=1&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of preclinical data to initiate the modified continual reassessment method for maximum tolerated dose-finding trials. AN - 70567534; 11144990 AB - This study was conducted to evaluate whether the allometric approach can be used to predict maximum tolerated dose (MTD) in humans from animal data. Twenty-five anticancer drugs were taken from the literature and used in this analysis. The results of the study indicate that MTD can be predicted with reasonable accuracy using interspecies scaling. The predicted MTD can then be applied to the modified continual reassessment method retrospectively for the selection of initial and subsequent doses of anticancer drugs in the patient population. This approach can save time and avoid many unnecessary steps to attain MTD in humans if it could be applied prospectively. JF - Journal of clinical pharmacology AU - Mahmood, I AD - Division of Pharmaceutical Evaluation I, Office of Clinical Pharmacology and Biopharmaceutics (HFD-860), Food and Drug Administration (FDA), Rockville, Maryland, USA. Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 19 EP - 24 VL - 41 IS - 1 SN - 0091-2700, 0091-2700 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Rats KW - Drug Screening Assays, Antitumor KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Dogs KW - Predictive Value of Tests KW - Mice KW - Species Specificity KW - Models, Biological KW - Haplorhini KW - Maximum Tolerated Dose KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70567534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Application+of+preclinical+data+to+initiate+the+modified+continual+reassessment+method+for+maximum+tolerated+dose-finding+trials.&rft.au=Mahmood%2C+I&rft.aulast=Mahmood&rft.aufirst=I&rft.date=2001-01-01&rft.volume=41&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2000-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro human tissue models in risk assessment: report of a consensus-building workshop. AN - 70564534; 11134541 AB - Advances in the technology of human cell and tissue culture and the increasing availability of human tissue for laboratory studies have led to the increased use of in vitro human tissue models in toxicology and pharmacodynamics studies and in quantitative modeling of metabolism, pharmacokinetic behavior, and transport. In recognition of the potential importance of such models in toxicological risk assessment, the Society of Toxicology sponsored a workshop to evaluate the current status of human cell and tissue models and to develop consensus recommendations on the use of such models to improve the scientific basis of risk assessment. This report summarizes the evaluation by invited experts and workshop attendees of the current status of such models for prediction of human metabolism and identification of drug-drug interactions, prediction of human toxicities, and quantitative modeling of pharmacokinetic and pharmaco-toxicodynamic behavior. Consensus recommendations for the application and improvement of current models are presented. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - MacGregor, J T AU - Collins, J M AU - Sugiyama, Y AU - Tyson, C A AU - Dean, J AU - Smith, L AU - Andersen, M AU - Curren, R D AU - Houston, J B AU - Kadlubar, F F AU - Kedderis, G L AU - Krishnan, K AU - Li, A P AU - Parchment, R E AU - Thummel, K AU - Tomaszewski, J E AU - Ulrich, R AU - Vickers, A E AU - Wrighton, S A AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA. macgregorj@cder.fda.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 17 EP - 36 VL - 59 IS - 1 SN - 1096-6080, 1096-6080 KW - Xenobiotics KW - 0 KW - Index Medicus KW - Humans KW - Xenobiotics -- pharmacokinetics KW - Culture Techniques KW - Cell Culture Techniques KW - Xenobiotics -- toxicity KW - Risk Assessment -- methods KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70564534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=In+vitro+human+tissue+models+in+risk+assessment%3A+report+of+a+consensus-building+workshop.&rft.au=MacGregor%2C+J+T%3BCollins%2C+J+M%3BSugiyama%2C+Y%3BTyson%2C+C+A%3BDean%2C+J%3BSmith%2C+L%3BAndersen%2C+M%3BCurren%2C+R+D%3BHouston%2C+J+B%3BKadlubar%2C+F+F%3BKedderis%2C+G+L%3BKrishnan%2C+K%3BLi%2C+A+P%3BParchment%2C+R+E%3BThummel%2C+K%3BTomaszewski%2C+J+E%3BUlrich%2C+R%3BVickers%2C+A+E%3BWrighton%2C+S+A&rft.aulast=MacGregor&rft.aufirst=J&rft.date=2001-01-01&rft.volume=59&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preparation of mycotoxin standards. AN - 70554759; 11050991 JF - Methods in molecular biology (Clifton, N.J.) AU - Nesheim, S AU - Stack, M E AD - Food and Drug Administration, Washington, DC, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 31 EP - 36 VL - 157 SN - 1064-3745, 1064-3745 KW - Mycotoxins KW - 0 KW - Solutions KW - Index Medicus KW - Reference Standards KW - Spectrophotometry, Ultraviolet KW - Chromatography, Liquid KW - Chromatography, Thin Layer KW - Mycotoxins -- isolation & purification KW - Mycotoxins -- standards KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70554759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Preparation+of+mycotoxin+standards.&rft.au=Nesheim%2C+S%3BStack%2C+M+E&rft.aulast=Nesheim&rft.aufirst=S&rft.date=2001-01-01&rft.volume=157&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Electrospray mass spectrometry for mycotoxin detection and purity analysis. AN - 70551052; 11050992 JF - Methods in molecular biology (Clifton, N.J.) AU - Wilkes, J G AU - Lay, J O AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 37 EP - 48 VL - 157 SN - 1064-3745, 1064-3745 KW - Carboxylic Acids KW - 0 KW - Fumonisins KW - Mycotoxins KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Methods KW - Reference Standards KW - Chromatography, High Pressure Liquid -- methods KW - Carboxylic Acids -- analysis KW - Mycotoxins -- isolation & purification KW - Mycotoxins -- standards KW - Mycotoxins -- analysis KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Mycotoxins -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70551052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Electrospray+mass+spectrometry+for+mycotoxin+detection+and+purity+analysis.&rft.au=Wilkes%2C+J+G%3BLay%2C+J+O&rft.aulast=Wilkes&rft.aufirst=J&rft.date=2001-01-01&rft.volume=157&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preparatory isolation of mycotoxins from solid phase fungal cultures. AN - 70544550; 11050990 JF - Methods in molecular biology (Clifton, N.J.) AU - Eppley, R M AD - Food and Drug Administration, Washington, DC, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 25 EP - 29 VL - 157 SN - 1064-3745, 1064-3745 KW - Carboxylic Acids KW - 0 KW - Fumonisins KW - Indicators and Reagents KW - Mycotoxins KW - fumonisin B2 KW - 116355-84-1 KW - fumonisin B3 KW - 136379-59-4 KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Index Medicus KW - Fusarium -- chemistry KW - Animals KW - Carboxylic Acids -- isolation & purification KW - Methods KW - Chromatography, High Pressure Liquid -- methods KW - Carboxylic Acids -- toxicity KW - Mycotoxins -- isolation & purification KW - Fungi -- chemistry KW - Mycotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70544550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Preparatory+isolation+of+mycotoxins+from+solid+phase+fungal+cultures.&rft.au=Eppley%2C+R+M&rft.aulast=Eppley&rft.aufirst=R&rft.date=2001-01-01&rft.volume=157&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Solid phase extraction method for patulin in apple juice and unfiltered apple juice. AN - 70540027; 11051004 JF - Methods in molecular biology (Clifton, N.J.) AU - Trucksess, M W AU - Tang, Y AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 205 EP - 213 VL - 157 SN - 1064-3745, 1064-3745 KW - Patulin KW - 95X2BV4W8R KW - Index Medicus KW - Animals KW - Humans KW - Patulin -- isolation & purification KW - Chromatography, Liquid -- methods KW - Beverages -- analysis KW - Patulin -- toxicity KW - Food Contamination -- analysis KW - Rosales -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70540027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Solid+phase+extraction+method+for+patulin+in+apple+juice+and+unfiltered+apple+juice.&rft.au=Trucksess%2C+M+W%3BTang%2C+Y&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2001-01-01&rft.volume=157&rft.issue=&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Mental Health: Culture, Race, and Ethnicity. A Supplement to "Mental Health: A Report of the Surgeon General." AN - 62264845; ED464308 AB - This supplement to "Mental Health: A Report of the Surgeon General" (1999) documents the existence of striking disparities for minorities in mental health services and the underlying knowledge base. Racial and ethnic minorities have less access to mental health services than whites, and they are less likely to receive needed care. When they receive care, it is more likely to be poor in quality. These disparities have powerful significance for minority groups and for society as a whole. A major finding of this supplement is that racial and ethnic minorities bear a greater burden from unmet mental health needs and thus suffer a greater loss to their overall health and productivity. Chapter 1 provides a detailed introduction to the supplement, and Chapter 2 discusses the influences of culture and society on mental health. Chapters 3 through 6 specifically address mental health care for African Americans, American Indians and Alaska Natives, Asian Americans and Pacific Islanders, and Hispanic Americans. Chapter 7 outlines a vision for the future and highlights promising courses of action that can be used to reach the ambitious goals of reducing barriers and promoting equal access to effective mental health services for all persons who need them. The report contains two appendixes, one that examines the inclusion of minorities in controlled clinical trials used to develop professional treatment guidelines for major mental disorders, and a detailed resource directory. (Contains over 500 references and an index.) (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 214 PB - Knowledge Exchange Network (KEN), P.O. Box 42490, Washington, DC 20015 (Inventory Number SMA-01-3613). Tel: 800-789-2647 (Toll Free); e-mail: ken@mentalhealth.org. For full text: http://www.surgeongeneral.gov/library/mentalhealth/cre/. KW - ERIC, Resources in Education (RIE) KW - Culture KW - Ethnicity KW - Blacks KW - Race KW - Mental Health KW - American Indians KW - Health Promotion KW - Public Health KW - Minority Groups KW - Hispanic Americans KW - Cultural Influences KW - Asian Americans KW - Pacific Islanders KW - Racial Factors KW - Alaska Natives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62264845?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For original report, see ED 441 209. Developed in N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Kids into Health Careers Kit. AN - 62263094; ED463442 AB - This complete Kids into Health Careers (KIHC) information package contains guidance materials to use when working with local school systems. It provides operating instructions on how to choose and address an audience, either at a school or community-based organization. (KIHC is an initiative being developed to supplement the pool of qualified applicants from economically and educationally disadvantaged and underrepresented minority populations for entry into health professions training.) The packet includes an overview booklet; a poster with information on the back about what KIHC is, why it is so important, who KIHC is trying to reach, examples of career opportunities in the health professions, and reference guides; an operating instructions booklet covering qualifying, financial aid, fulfilling a need, selection criteria, addressing target audiences, and reporting elements; and a booklet with presentation models for students K-5, students 6-12, parents, and teachers, counselors, and school administrators. Appended are a list of 17 references detailing career opportunities in the health field; additional information on specific health careers and certificate positions; a list of 30 sources of financial aid; and a list of federally-funded health facility contacts for additional information. (YLB) AU - Hollins, Anthony AU - Davis, Maurice AU - Horne, Devonaline T. Y1 - 2001 PY - 2001 DA - 2001 SP - 93 PB - For Web-based version: http://www, bhprhrsagov/kidscareers/ KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Educational Finance KW - Elementary Secondary Education KW - Career Exploration KW - Career Choice KW - Medical Education KW - Health Occupations KW - Student Financial Aid KW - Occupational Information KW - Health Needs KW - Allied Health Occupations Education KW - Minority Groups KW - Economically Disadvantaged KW - Student Recruitment KW - Educationally Disadvantaged KW - Career Education KW - Affirmative Action KW - Vocational Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62263094?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Kids into Health Careers (KIHC) Initiative packet N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - A Provider's Introduction to Substance Abuse Treatment for Lesbian, Gay, Bisexual, and Transgender Individuals. AN - 62263058; ED463489 AB - This document seeks to inform administrators and clinicians about appropriate diagnosis and treatment approaches that will help ensure the development or enhancement of effective lesbian-, gay-, bisexual-, and transgender (LGBT)-sensitive programs. Serving as both a reference tool and program guide, it provides statistical and demographic information, prevalence data, case examples and suggested interventions, treatment guidelines and approaches, and organizational policies and procedures. Section one provides an introduction and includes information on sexual orientation, legal issues, and treatment approaches and modalities from a lesbian, gay, bisexual, and transgender standpoint. Section two, written for the practicing clinician, offers further information on clinical issues of LGBT clients; an introduction to strategies and methods for improving current services to LGBT individuals; and steps for starting LGBT-sensitive programs. Section three, developed for program administrators, provides an overview of the issues that need to be addressed when developing a LGBT program or when expanding current services for LGBT clients. It offers the data needed to build a strong foundation for a program, including an organizational mission and policies and procedures. Also provided are resources and strategies for working with managed care organizations and building alliances and cooperative arrangements to coordinate efforts on behalf of LGBT individuals. Appended are: Glossary of Terms; Acronyms; and Studies on LGBT Substance Abuse. (Contains 260 references.) (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 213 PB - U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatments, Rockwall II, 5600 Fishers Lane, Rockville, MD 20857. KW - Transsexuals KW - ERIC, Resources in Education (RIE) KW - Sexual Orientation KW - Lesbianism KW - Substance Abuse KW - Counseling Techniques KW - Clinical Diagnosis KW - Administrator Role KW - Bisexuality KW - Program Development KW - Counseling Services KW - Homosexuality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62263058?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Pages 12 and 13 with Exhibit 1-1: Coleman's Assess N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Indicators of Welfare Dependence. Annual Report to Congress, 2001. AN - 62260056; ED457288 AB - This fourth annual report addresses the extent to which U.S. families depend on income from welfare programs, providing updated data on measures of welfare recipiency, dependency, and predictors of welfare dependence developed for previous reports. It highlights benefits under Aid to Families with Dependent Children (AFDC), now Temporary Assistance for Needy Families (TANF); the Food Stamp Program; and Supplemental Security Income (SSI). The report uses data from the Current Population Survey and administrative data to provide updated measures through 1998 for several dependency indicators. Other measures are based on the Survey of Income and Program Participation and other data sources. Results indicate: in 1998, 3.8 percent of the total population was dependent (a drop from 5.8 percent in 1993); the drop in dependency paralleled the drop in AFDC/TANF and food stamp caseloads; long-term dependency was relatively rare; and as the dependency rate fell, the poverty rate for all people also fell. Four appendixes present: data on AFDC, TANF, the Food Stamp Program, and SSI; an alternative definition of dependence based on income from AFDC/TANF and food stamps; additional non-marital birth data; and sources of data. (SM) Y1 - 2001 PY - 2001 DA - 2001 SP - 198 PB - Office of Human Services Policy, Assistant Secretary for Planning and Evaluation, Hubert H. Humphrey Building, Room 410E, 200 Independence Avenue, S.W., Washington, DC 20201. KW - Aid to Families with Dependent Children KW - Dependency (Economics) KW - Food Stamp Program KW - Supplemental Security Income Program KW - Temporary Assistance for Needy Families KW - ERIC, Resources in Education (RIE) KW - Poverty KW - Welfare Recipients KW - Family Problems KW - Welfare Services KW - Family Income KW - Children KW - Tables (Data) KW - One Parent Family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62260056?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For the 2000 report, see ED 441 908. Contributors N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - The Starting Early Starting Smart Story. AN - 62259994; ED463490 AB - Starting Early Starting Smart (SESS) is an early childhood public/private initiative designed to identify new, empirical knowledge about the effectiveness of integrating substance abuse prevention, addictions treatment, and mental health services with primary health care and childcare service settings (e.g., Head Start, day care, preschool) to reach very young children (ages 0-7) and their families at risk for or experiencing substance abuse and/or mental illness. Knowledge from these projects is designed not only to establish best practices but also to inform future policy decisions about such integrated approaches to prevention. This publication documents some of the most promising practices and early lessons learned in SESS programs. Contains two appendixes detailing mission statements of the SESS national collaborators and SESS grant sites. (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 70 VL - BKD-435 KW - Project Head Start KW - ERIC, Resources in Education (RIE) KW - At Risk Persons KW - Integrated Services KW - Substance Abuse KW - Cognitive Development KW - Young Children KW - Delivery Systems KW - Mental Health Programs KW - Early Childhood Education KW - Primary Health Care KW - Prevention KW - Family Programs KW - Child Rearing KW - Program Development KW - Addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62259994?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Cover page title, "The SESS Story." Photographic i N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Women's Health in the Baccalaureate Nursing School Curriculum: Report of a Survey and Recommendations. AN - 62258677; ED464547 AB - This report presents the analytical results of a survey of U.S. baccalaureate nursing schools conducted during 1999 by the American Colleges of Nursing with a description of the extent of women's health content in the curriculum and selected recommendations designed to strengthen this content. Additional resources are included that describe the essentials of baccalaureate nursing education, fundamental features of women's health care, and the significant contribution of nurses in providing comprehensive women's health care. The survey was sent to deans or directors at 521 schools in the United States that had entry level baccalaureate nursing programs. Responses were received from 334 schools (64%). Results of the survey show that a large majority of entry-level baccalaureate nursing education programs do include a high percentage of women's health topics in the curriculum. One topic (the impact of race/ethnicity/culture on health status, health beliefs and behaviors, and health care use) was included in the curriculum of every school reporting. Domestic violence and rape were included in the required course content of 95% and 92% of the nursing education programs, and childhood abuse was included in 94% of the programs reporting. Areas for improvement are identified, and some specific recommendations are made. Nine appendixes contain supplemental information related to the survey methods and findings. Survey instrument is included. (Contains 38 tables and 19 references.) (SLD) Y1 - 2001 PY - 2001 DA - 2001 SP - 153 PB - Health Resources and Services Administration, U.S. Department of Health and Human Resources, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857 (Inventory code: BHP00133). KW - ERIC, Resources in Education (RIE) KW - Course Content KW - Bachelors Degrees KW - Administrators KW - Gender Issues KW - Nursing Education KW - Curriculum KW - Nursing Students KW - Surveys KW - Higher Education KW - Health KW - Females UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62258677?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Women and Smoking: A Report of the Surgeon General [and] Executive Summary. AN - 62251485; ED456393 AB - This is the second report of the Surgeon General devoted to women and smoking. First signs of an epidemic of tobacco related diseases among women are no longer being seen, as they were first reported in 1980. Lung cancer is now the leading cause of female cancer deaths, but cancer is just one of the serious risks faced by women who smoke. Female smokers are uniquely at risk for diseases related to pregnancy; oral contraceptives; menstrual functioning; and cervical cancer. Chapter 1 summarizes the report. Chapter 2 discusses the patterns of tobacco use among women and girls. Chapter 3 reviews the effects of tobacco on women's health. Chapter 4 presents the factors that influence tobacco use by women and chapter 5 discusses efforts to reduce tobacco use among women. The report concludes with a vision for the future. (Contains 109 tables, 48 figures, and over 300 references.) (JDM) Y1 - 2001 PY - 2001 DA - 2001 SP - 714 PB - U.S. Government Printing Office, Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402-9328. For full text: http://www.surgeongeneral.gov/library. KW - ERIC, Resources in Education (RIE) KW - Smoking KW - Prevention KW - Public Health KW - Tobacco KW - Government Publications KW - Females KW - Health Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62251485?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Prepared by DHHS under the general direction of DH N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - National Strategy for Suicide Prevention: Goals and Objectives for Action. AN - 62250838; ED456371 AB - This guide is designed to be a catalyst for social change, and to transform attitudes, policies, and services concerned with suicide prevention to reflect current knowledge. It involves a comprehensive and integrated approach to reducing the loss and suffering from suicide and suicidal behaviors in the United States. Representing the combined work of advocates, clinicians, researchers, and survivors, the strategy lays out a framework for action and guides the development of an array of services and programs for the future. It strives to promote and provide direction to efforts to modify the social infrastructure in ways that will affect attitudes about suicide and that will also change judicial, educational, social service, and health care systems. The public health approach is a rational and organized way to direct prevention efforts and ensure that they are effective. This national strategy represents the first attempt to prevent suicide through a coordinated approach between all levels of the government and the private sector. The Goals and Objectives for Action consist of 11 goals and 68 objectives that serve as the blueprint for action. Appendices include the following: "NSSP Goals and Objectives for Action": Summary List; Evaluation of Suicide Prevention Programs; Suicide Prevention Efforts in Process of Evaluation; NSSP Federal Steering Group Agency Descriptions; and Glossary. (Contains 197 references.) (JDM) AU - Silverman, Morton M. Y1 - 2001 PY - 2001 DA - 2001 SP - 232 PB - Center for Mental Health Services' Knowledge Exchange Network, P.O. Box 42490, Washington, DC 20015. Tel: 800-789-2647 (Toll Free). For full text: http://www.mentalhealth.org/suicideprevention. For full text: http://www.surgeongeneral.gov.library. KW - Suicide Prevention KW - ERIC, Resources in Education (RIE) KW - Prevention KW - Public Health KW - Community Action KW - Cooperation KW - Program Development KW - National Programs KW - Suicide KW - Change Strategies KW - Social Structure KW - Health Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62250838?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Assistance in preparing this publication was also N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Off to a Good Start: Research on the Risk Factors for Early School Problems and Selected Federal Policies Affecting Children's Social and Emotional Development and Their Readiness for School. AN - 62196910; ED476378 AB - In order to examine the responsiveness of federal policies to the known risk and protective factors for academic and behavior problems at the beginning of school, the Child Mental Health Foundations and Agencies Network commissioned the two papers that make up this publication. One paper reviews the last two decades of relevant scientific literature concerning the risk factors known to affect young children's social-emotional school readiness adversely and the gaps that exist in the research base. The other paper identifies the federal policies and programs that address these risk factors. Taken together, the two papers identify the gaps between what we know regarding risk and protective factors and the programs that are currently implemented to address them. Includes extensive references and data tables. (Author/SG) AU - Huffman, Lynne C. AU - Mehlinger, Sarah L. AU - Kerivan, Amy S. AU - Cavanaugh, Doreen A. AU - Lippitt, John AU - Moyo, Otrude Y1 - 2001 PY - 2001 DA - 2001 SP - 231 KW - ERIC, Resources in Education (RIE) KW - At Risk Persons KW - Toddlers KW - Educational Legislation KW - Early Childhood Education KW - Mental Health KW - Behavior Problems KW - Emotional Development KW - Environmental Influences KW - Federal Programs KW - Emotional Problems KW - Early Intervention KW - Social Development KW - School Readiness KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62196910?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - RETROspective: A Parent's Guide to Youth Culture. Building Bridges between Generations. AN - 62195435; ED465946 AB - Recognizing expressions of youth culture is a major step toward understanding teens. This understanding can help parents keep lines of communication open between them and their teens. Making it clear that you do not want your child to use alcohol, tobacco, or illicit drugs is a proven factor in reducing youth drug use. RETROspective is designed to immerse the reader in expressions of youth culture by presenting a guided tour through American youth culture from the 1950s to the present. In addition to illustrating expressions of the culture, RETROspective explains what youth culture is and how it is reflected everywhere, its influence on youth's attitudes and behaviors, the role of media and music in the culture, and the importance of media literacy in a media driven society. Lastly, RETROspective includes "Building Bridges," a feature that offers suggestions for starting conversations with youth about various topics, including alcohol, tobacco, illicit drugs, and media influences. (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 31 PB - National Clearinghouse for Alcohol and Drug Information, P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729-6686 (Toll Free). For full text: http://www.health.org. KW - Media Literacy KW - Youth Culture KW - ERIC, Resources in Education (RIE) KW - Parents KW - Cultural Context KW - Adolescent Behavior KW - Parent Materials KW - Parent Child Relationship KW - Generation Gap KW - North American Culture KW - Drug Use KW - Adolescents KW - Mass Media Role KW - Adolescent Attitudes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62195435?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Promising and Proven Substance Abuse Prevention Programs. Guide to Science-Based Practices. AN - 62187173; ED469595 AB - For more than a decade, the Substance Abuse and Mental Health Services Administrations Center for Substance Abuse Prevention (CSAP) has supported demonstration programs designed to identify interventions that work with populations at high risk to prevent substance abuse, delay its onset, and reduce substance abuse-related behaviors. Research now confirms that interventions aimed at reducing the risk factors and increasing the protective factors linked to substance abuse and related problem behavior can produce immediate and long-term positive results. Substance abuse is a complex problem that develops in response to multiple influences. Spheres of activity within the community--typically called domains--include the individual, family, peer, school, community, and society/environment. Each domain presents an opportunity for preventive action. This document presents a comprehensive compilation of both proven and promising interventions in an easy-to-scan grid, organized by risk factor and domain. For each intervention, the grid also includes information on target age, Institute of Medicine (IOM) prevention classification, program outcome, and the strategies specified in the Substance Abuse Prevention and Treatment (SAPT) block grant legislation. (Contains 63 references.) (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 47 KW - Risk Factors KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Policymakers KW - Evaluation Methods KW - Program Effectiveness KW - Prevention KW - Substance Abuse KW - Scientific Research KW - Program Implementation KW - Program Evaluation KW - Behavior Problems KW - Outcomes of Treatment KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62187173?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Based on "A Guide to Science-Based Practices in Su N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Science-Based Substance Abuse Prevention: A Guide. Guide to Science-Based Practices. AN - 62185558; ED469594 AB - The Substance Abuse and Mental Health Services Administrations Center for Substance Abuse Prevention (CSAP) is responsible for identifying and disseminating scientifically defensible knowledge about proven prevention models and principles to the substance abuse prevention field. This booklet is intended to assist prevention practitioners and others involved in the design, implementation, and evaluation of substance abuse prevention programs. This document provides the following: describes the evolution of the conceptual model that CSAP uses to provide a unifying framework for substance abuse prevention; discusses the principles that provide the foundation for understanding and defining research findings as scientifically defensible; and illustrates how CSAP applies specific principles and criteria to research studies, program evaluations, and scholarly efforts to identify scientifically defensible findings, prevention principles, and prevention models. The guide also provides specifics about the CSAP methodology for selecting model programs and identifying scientifically defensible principles. It is one in a series of three products that together assist prevention practitioners, evaluators, state and local program administrators, policymakers, and funders in designing and assessing scientifically defensible programs. (Contains 25 references.) (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 25 KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Practitioners KW - Policymakers KW - Evaluation Methods KW - Program Effectiveness KW - Prevention KW - Substance Abuse KW - Scientific Research KW - Program Implementation KW - Program Evaluation KW - Outcomes of Treatment KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62185558?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Based on "A Guide to Science-Based Practices in Su N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Principles of Substance Abuse Prevention. Guide to Science-Based Practices. AN - 62185514; ED469596 AB - For more than a decade, the Substance Abuse and Mental Health Services Administrations Center for Substance Abuse Prevention (CSAP) has supported demonstration programs designed to identify interventions that work with high-risk populations to prevent substance abuse, delay its onset, and reduce substance abuse-related behaviors. Research now confirms that interventions aimed at reducing the risk factors and increasing the protective factors linked to substance abuse and related problem behavior can produce immediate and long-term positive results. Effective interventions share certain principles that guide prevention providers in structuring client services. The principles appearing in this document have been identified through expert or peer consensus efforts such as consensus panels and meta-analyses. Many have also been published in peer-reviewed journals. Appropriate use of these scientifically defensible principles can assist prevention providers in designing services that are both innovative and effective, and in modifying proven models to respond to the specialized needs of individual programs. (Contains 155 references.) (GCP) Y1 - 2001 PY - 2001 DA - 2001 SP - 41 KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Program Effectiveness KW - At Risk Persons KW - Prevention KW - Substance Abuse KW - Program Implementation KW - Intervention KW - Behavior Problems KW - Outcomes of Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62185514?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Based on "A Guide to Science-Based Practices in Su N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Mental Health, United States, 2000. AN - 62181002; ED469203 AB - In recent years, the mental health community has made great strides in understanding more about the delivery of mental health services, improving efficiency and quality in services, and also about how to build strengths and resilience in the face of lifes stresses. This volume adds to the knowledge base so that the important task of system change and expansion of service availability can proceed. Through a knowledge exchange process, this volume seeks to highlight the challenges in the field of mental health and respond with useful information. Chapters include: (1) Where is Mental Health Likely to Be a Century Hence? (Ronald W. Manderscheid, Marilyn J. Henderson); (2) Mental Health Policy in 20th-Century America (Gerald N. Grob); (3) Decision Support 2000+: A New Information System for Mental Health (Marilyn J. Henderson, Sarah L. Minden; Ronald W. Manderscheid); (4) Information Needs: A Consumer and Family Perspective (Laura Van Tosh); (5) Psychiatric Epidemiology: Recent Advances and Future Directions (Ronald C. Kessler, Elizabeth J. Costello, Kathleen Ries Merikangas, T. Bedirhan Ustun); (6) Status of National Accountability Efforts at the Millennium (Ronald W. Manderscheid, Marilyn J. Henderson, David Y. Brown); (7) Mental Health Policy at the Millennium: Challenges and Opportunities (David Mechanic); (8) The Mental Health Economy and Mental Health Economics (Richard G. Frank, Thomas McGuire); (9) The Promise and Reality of Managed Behavioral Care (E. Clarke Ross); (10) Co-occurring Addictive and Mental Disorders (Fred C. Osher); (11) Adult Mental Health Services in the 21st Century (Mark S. Salzer, Michael Blank, Aileen Rothbard, Trevor Hadley); (12) Pharmacoepidemiology of Methylphenidate and Other Medications for the Treatment of ADHD (Julie Magno Zito); (13) Refugee Mental Health: Issues for the New Millenium (James Jaranson, Susan Forbes Martin, Solvig Ekblad); (14) Highlights of Organized mental Health Services in 1998 and Major National and State Trends (Ronald W. Manderscheid, And Others); (15) Persons Treated in Specialty Mental Health Care Programs, United States, 1997 (Laura J. Milazzo-Sayre, And Others); (16) State Mental Health Agency Controlled Expenditures and Revenues for Mental Health Services, FY 1981 to FY 1997 (Ted Lutterman, Michael Hogan); (17) The 16-State Indicator Pilot Grant Project: Selected Performance Indicators and Implications for Policy- and Decisionmaking (Olinda Gonzalez, And Others); (18) The Availability of Mental Health Services to Young People in Juvenile Justice Facilities: A National Survey (Ingrid Goldstrom, Fan Jaiquan, Marilyn Henderson, Alisa Male, Ronald W. Manderscheid); (19) Estimates of Mental and Emotional Problems, Functional Impairments, and Associated Disability Outsomes for the U.S. Child Population in Households (Lisa J. Colpe); and (20) Mental Health Practitioners and Trainees (Joyce West, And Others). (Contains over 500 references, 64 tables, and 4 appendixes.) (GCP) AU - Manderscheid, Ronald W. AU - Henderson, Marilyn J. Y1 - 2001 PY - 2001 DA - 2001 SP - 359 PB - U.S. Government Printing Office, Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402-0001. Tel: 202-512-1800; Fax: 202-512-2250; Web site: bookstore.gpo.gov. VL - SMA-01-3537 KW - Knowledge Bases KW - ERIC, Resources in Education (RIE) KW - Program Effectiveness KW - Information Dissemination KW - Delivery Systems KW - Mental Health Programs KW - Mental Health KW - Change Strategies KW - Trend Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62181002?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Motivational Enhancement Therapy and Cognitive Behavioral Therapy for Adolescent Cannabis Users: 5 Sessions. Cannabis Youth Treatment (CYT) Series, Volume 1. AN - 62148925; ED478681 AB - This manual is designed to help train substance abuse treatment counselors to conduct a brief five-session treatment intervention for adolescents with cannabis use disorders presenting for outpatient treatment. It combines two sessions of motivational enhancement therapy provided individually and three sessions of cognitive behavioral therapy provided in a group format. The program is referred to as MET/CBT5. Although this will be one of the first applications of these approaches to adolescent treatment, related brief intervention approaches with adults have proved very effective. In the Cannabis Youth Treatment study, the approach was also an efficient intervention because its personalized feedback report was based on the intake assessments already done as part of the research protocol. The treatment described in this manual was designed to address the problem of marijuana use by adolescents. Section I reviews the scope, effects, and patterns of the marijuana problem. Section II provides a brief overview of the Cannabis Youth Treatment project for which this manual was developed. Section III covers the scientific basis for this intervention. Section IV provides step-by-step procedures for actually implementing this treatment protocol. Five appendixes contain therapist session reports, supervisor session rating reports, poster facsimiles, personalized feedback reports, and a study on clinical management of a field trial of five outpatient treatments for adolescent substance abuse. (Contains 67 references.) (GCP) AU - Sampl, Susan AU - Kadden, Ronald Y1 - 2001 PY - 2001 DA - 2001 SP - 157 KW - ERIC, Resources in Education (RIE) KW - Substance Abuse KW - Counseling Techniques KW - Motivation KW - Behavior Modification KW - Counseling Effectiveness KW - Intervention KW - Cognitive Restructuring KW - Marijuana KW - Drug Rehabilitation KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62148925?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - The Adolescent Community Reinforcement Approach for Adolescent Cannabis Users, Cannabis Youth Treatment (CYT) Series, Volume 4. AN - 62148086; ED478684 AB - This publication was written for therapists and their supervisors who may want to implement the adolescent community reinforcement approach intervention, which was one of the five interventions tested by the Center for Substance Abuse Treatment's (CSAT's) Cannabis Youth Treatment (CYT) Project. The CYT Project provided funding to support a study that tested the effectiveness of five interventions designed to reduce or eliminate marijuana use and associated problems in adolescents. Although information is still emerging about adolescent treatment effectiveness, there is considerable tension between efforts to develop short, cost-effective treatments and findings that 50 percent or more of adolescents relapse to marijuana or alcohol use within the first 3 months after discharge. There are, however, several promising options for improving treatment effectiveness that focus on motivational enhancement, relapse prevention, problem solving, coping strategies, case management, family support, family therapy, and working with adolescent' to change their environments. This manual guides therapists and their supervisors in using the adolescent community reinforcement approach (ACRA) intervention with adolescents and their caregivers. The guide provides examples of exchanges between therapists and adolescents to illustrate how therapists help adolescents find or enhance reinforcers to abstinence, use community resources to support change, and develop family support. An appendix includes a detailed account of the CYT study. (Contains 51 references.) (GCP) AU - Godley, Susan Harrington AU - Meyers, Robert J. AU - Smith, Jane Ellen AU - Karvinen, Tracy AU - Titus, Janet C. AU - Godley, Mark D. AU - Dent, George AU - Passetti, Lora AU - Kelberg, Pamela Y1 - 2001 PY - 2001 DA - 2001 SP - 252 KW - ERIC, Resources in Education (RIE) KW - Family Support KW - Substance Abuse KW - Motivation KW - Community Role KW - Intervention KW - Theory Practice Relationship KW - Community Involvement KW - Marijuana KW - Outcomes of Treatment KW - Counseling Techniques KW - Behavior Modification KW - Counseling Effectiveness KW - Reinforcement KW - Cognitive Restructuring KW - Drug Rehabilitation KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62148086?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For Volume 1, see CG 032 480; for Volume 2, see CG N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Family Support Network for Adolescent Cannabis Users, Cannabis Youth Treatment (CYT) Series, Volume 3. AN - 62147149; ED478683 AB - Substance-abusing adolescents experiencing inadequate family structure and functioning will be at a serious disadvantage with regard to recovery. The family support network (FSN) intervention seeks to extend the focus of treatment beyond the world of the adolescent by engaging the family, a major system in his or her life. Designed to increase parental support of a child's recovery, the FSN approach seeks to engage families in the treatment process, improve parents' competence in supporting their child's recovery, and shift therapy from time-limited formal treatment to a support group for parents. The FSN process is a family intervention designed to be used in conjunction with any standard adolescent treatment approach. The procedures presented in this manual combine motivational enhancement and cognitive behavioral therapies as one possible treatment overlay for the adolescent. The motivational enhancement therapy (MET) and cognitive behavioral therapy (CBT) approaches used in the Cannabis Youth Treatment (CYT) study are presented in "Motivational Enhancement Therapy and Cognitive Behavioral Therapy for Adolescent Cannabis Users: 5 Sessions, Cannabis Youth Treatment Series, Volume 1" and "The Motivational Enhancement Therapy and Cognitive Behavioral Therapy Supplement: 7 Sessions of Cognitive Behavioral Therapy for Adolescent Cannabis Users, Cannabis Youth Treatment Series, Volume 2." Thus, while an adolescent is receiving a special MET/CBT program for adolescents, the family is involved in the FSN intervention. This manual guides counselors and therapists, so they can consistently conduct effective case management. The appendixes include quality assurance materials and a detailed account of the CYT study. (Contains 29 references.) (GCP) AU - Hamilton, Nancy L. AU - Brantley, Laura Bunch AU - Tims, Frank M. AU - Angelovich, Nancy AU - McDougall, Barbara Y1 - 2001 PY - 2001 DA - 2001 SP - 148 KW - ERIC, Resources in Education (RIE) KW - Family Support KW - Substance Abuse KW - Motivation KW - Intervention KW - Theory Practice Relationship KW - Marijuana KW - Outcomes of Treatment KW - Counseling Techniques KW - Behavior Modification KW - Counseling Effectiveness KW - Cognitive Restructuring KW - Drug Rehabilitation KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62147149?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - For Volume 1, see CG 032 480; for Volume 2, see CG N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Mental Health and Substance Abuse Services in Ten State Medicaid Programs AN - 61510183; 200204846 AB - Program data for 1993 on Medicaid mental health & substance abuse (MH/SA) services & expenditures were developed from Health Care Financing Administration (HCFA) research files for 10 states. These data show that MH/SA service users are 7% to 13% of Medicaid enrollees. The percentage of Medicaid enrollees accounted for by MH/SA users increases with age, reaching a fifth of the 45-64 age group. Across the 10 states, MH/SA spending represents 11% of total Medicaid expenditures. When their expenditures for non-MH/SA services are also considered, MH/SA users account for 28% of total Medicaid expenditures. 6 Tables, 7 References. Adapted from the source document. JF - Administration and Policy in Mental Health AU - Buck, Jeffrey A AU - Teich, Judith L AU - Bae, Jay AU - Dilonardo, Joan AD - Center Mental Health Services, SAMHSA, Rockville, MD jbuck@samhsa.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 181 EP - 192 VL - 28 IS - 3 SN - 0894-587X, 0894-587X KW - Substance Abuse KW - United States of America KW - Medicaid KW - Government Spending KW - States (Political Subdivisions) KW - Mental Health Services KW - Treatment KW - Health Care Utilization KW - article KW - 6129: addiction KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61510183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health&rft.atitle=Mental+Health+and+Substance+Abuse+Services+in+Ten+State+Medicaid+Programs&rft.au=Buck%2C+Jeffrey+A%3BTeich%2C+Judith+L%3BBae%2C+Jay%3BDilonardo%2C+Joan&rft.aulast=Buck&rft.aufirst=Jeffrey&rft.date=2001-01-01&rft.volume=28&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health&rft.issn=0894587X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Substance Abuse; Medicaid; Mental Health Services; Health Care Utilization; States (Political Subdivisions); United States of America; Government Spending; Treatment ER - TY - JOUR T1 - The Impact of Age, Gender, and Race on the Relationship between Depression and Self-Rated Health in Community-Dwelling Older Adults: A Longitudinal Study AN - 61497425; 200300134 AB - Examines whether the prediction of baseline depression for subsequent changes in self-rated health is consistent across different age cohorts, gender, & racial groups. Using a two-year prospective cohort study, participants (N = 6,714) aged 65+ & who took part in both the first & the second wave of Assets & Health Dynamics among the Oldest-Old (AHEAD) national survey of community-dwelling older adults were examined. Baseline depression was an independent risk factor, which not only decreased the odds of having substantial improvement in self-rated health but also increased the possibility of having substantial decline in self-rated health in older men & women, & in Blacks & Whites of all age groups. Early prevention & treatment of depression among community-dwelling older adults may not only reduce their health decline but also promote their health. 6 Tables, 37 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Home Health Care Services Quarterly AU - Han, Beth AD - Special Populations Research Branch, Division Programs Special Populations, Bureau Primary Health Care, Health Resources & Services Administration, Bethesda, MD bhan@hrsa.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 27 EP - 43 VL - 20 IS - 3 SN - 0162-1424, 0162-1424 KW - Black White Differences KW - Depression (Psychology) KW - Sex Differences KW - Elderly KW - Health KW - Age Differences KW - article KW - 6142: mental & emotional health problems KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61497425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+Health+Care+Services+Quarterly&rft.atitle=The+Impact+of+Age%2C+Gender%2C+and+Race+on+the+Relationship+between+Depression+and+Self-Rated+Health+in+Community-Dwelling+Older+Adults%3A+A+Longitudinal+Study&rft.au=Han%2C+Beth&rft.aulast=Han&rft.aufirst=Beth&rft.date=2001-01-01&rft.volume=20&rft.issue=3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Home+Health+Care+Services+Quarterly&rft.issn=01621424&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HHCQDJ N1 - SubjectsTermNotLitGenreText - Health; Depression (Psychology); Elderly; Sex Differences; Age Differences; Black White Differences ER - TY - BOOK T1 - Trends in Indian health, 1998-99 AN - 59850383; 2003-0802020 AB - Structure of the Indian Health Service and health status of American Indians and Alaska natives. Includes birth, mortality, patient care, and community health statistics. JF - United States Indian Health Service, 2001. Y1 - 2001///0, PY - 2001 DA - 0, 2001 PB - United States Indian Health Service KW - Alaska -- Native races -- Health KW - United States -- Native races -- Health KW - Indians -- Health -- Statistics KW - United States -- Indian health service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59850383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Trends+in+Indian+health%2C+1998-99&rft.title=Trends+in+Indian+health%2C+1998-99&rft.issn=&rft_id=info:doi/ L2 - http://www.ihs.gov/PublicInfo/Publications/trends98/trends98.asp LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Indian Health Service N1 - Document feature - chart(s), index(es), map(s), table(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Youth violence: a report of the Surgeon General AN - 59838432; 2001-0901840 AB - Summarizes research and clarifies contradictory trends, such as discrepancies between official records of youth violence and young people's self-reports of violent behaviors; steps that Americans can take to address the problem; 1980s-1990s; US. JF - United States Department of Health and Human Services, 2001. Y1 - 2001///0, PY - 2001 DA - 0, 2001 PB - United States Department of Health and Human Services KW - Violence -- Research KW - Youth -- Social aspects KW - Violence -- Prevention KW - United States -- Social conditions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59838432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Youth+violence%3A+a+report+of+the+Surgeon+General&rft.title=Youth+violence%3A+a+report+of+the+Surgeon+General&rft.issn=&rft_id=info:doi/ L2 - http://www.surgeongeneral.gov/library/youthviolence/report.html LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Document feature - bibl(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Improving the health and health care of older Americans: a report of the AHRQ Task Force on Aging AN - 59834690; 2001-1106910 AB - Recommendations for coordination and role of the Agency for Healthcare Research and Quality in developing, implementing, and disseminating an agenda on health services research related to aging; US. Also available in print (Pubn. no. 01-0030). Based on organizational documents and discussions with related federal agencies and private organizations, 1999. JF - United States Agency for Healthcare Research and Quality, 2001. Y1 - 2001///0, PY - 2001 DA - 0, 2001 PB - United States Agency for Healthcare Research and Quality KW - Old age -- Health KW - Health planning -- United States KW - United States -- Health policy KW - Medical service -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59834690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Improving+the+health+and+health+care+of+older+Americans%3A+a+report+of+the+AHRQ+Task+Force+on+Aging&rft.title=Improving+the+health+and+health+care+of+older+Americans%3A+a+report+of+the+AHRQ+Task+Force+on+Aging&rft.issn=&rft_id=info:doi/ L2 - http://www.ahcpr.gov/research/olderam/oldam1.htm LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Agency Healthcare Research and Quality N1 - Document feature - chart(s), link(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Mental health: a report of the Surgeon General AN - 59833193; 2001-0901910 AB - Reviews scientific advances in the study of mental health and illnesses that affect at least one in five Americans; covers children, adults, and older adults; organization and finance of mental health services; confidentiality of mental health information: ethical, legal, and policy issues; and actions for the future; US. Approach to public health; burden of mental illness on health and productivity; inseparability of physical and mental health; and historical stigmatization of people with mental disorders. JF - United States Department of Health and Human Services, 2001. Y1 - 2001///0, PY - 2001 DA - 0, 2001 PB - United States Department of Health and Human Services KW - Mentally ill -- Care and treatment KW - Public health -- Finance KW - Medical records -- Legal aspects KW - United States -- Health conditions KW - Mental health -- United States KW - Medical ethics -- Legal aspects KW - United States -- Health policy KW - United States -- Surgeon general KW - Privacy -- Legal aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59833193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Mental+health%3A+a+report+of+the+Surgeon+General&rft.title=Mental+health%3A+a+report+of+the+Surgeon+General&rft.issn=&rft_id=info:doi/ L2 - http://www.surgeongeneral.gov/library/mentalhealth/home.html LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Document feature - bibl(s), il(s), table(s), chart(s) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Mental health: culture, race, and ethnicity: a supplement to "Mental health: a report of the Surgeon General" AN - 59831250; 2001-0901280 AB - Examines historical and cultural context within which minority mental health may be better understood; hardships endured; strength, energy, and optimism in minorities' quest for good mental health; disparities in health services; and related issues; with historical references; US. Also available in print (inventory no. SMA-01-3613). "Mental health: a report of the Surgeon General" indexed in PAIS International, 1999; available on the Internet at: www.surgeongeneral.gov/library/mentalhealth/home.html JF - United States Department of Health and Human Services, 2001. Y1 - 2001///0, PY - 2001 DA - 0, 2001 PB - United States Department of Health and Human Services KW - Mentally ill -- Care and treatment KW - Mental health -- United States KW - United States -- Health conditions KW - Minorities -- Mental health KW - United States -- Surgeon general KW - Medical service -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59831250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Mental+health%3A+culture%2C+race%2C+and+ethnicity%3A+a+supplement+to+%22Mental+health%3A+a+report+of+the+Surgeon+General%22&rft.title=Mental+health%3A+culture%2C+race%2C+and+ethnicity%3A+a+supplement+to+%22Mental+health%3A+a+report+of+the+Surgeon+General%22&rft.issn=&rft_id=info:doi/ L2 - http://www.surgeongeneral.gov/library/mentalhealth/cre/sma-01-3613.pdf LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Document feature - bibl(s), table(s), index(es) N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Report of the Surgeon General's Conference on Children's Mental Health: a national action agenda AN - 59826992; 2001-0301800 AB - Some focus on public awareness, citizen participation in prevention, identification, recognition, referral of children with mental health needs, and treatment services; US. Conference held Sept. 18-19, 2000, Washington, DC. Also available in print (ISBN 0-16-050637-9) (Stock no. 017-024-01659-4). Collaboration among Department of Health and Human Services, Department of Justice, and Department of Education. JF - United States Department of Health and Human Services, 2001. AU - Olin, S Serene Y1 - 2001///0, PY - 2001 DA - 0, 2001 PB - United States Department of Health and Human Services KW - Child health -- United States KW - Children -- Mental health KW - Child welfare -- United States KW - Mental health -- United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59826992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Olin%2C+S+Serene&rft.aulast=Olin&rft.aufirst=S&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Report+of+the+Surgeon+General%27s+Conference+on+Children%27s+Mental+Health%3A+a+national+action+agenda&rft.title=Report+of+the+Surgeon+General%27s+Conference+on+Children%27s+Mental+Health%3A+a+national+action+agenda&rft.issn=&rft_id=info:doi/ L2 - http://www.surgeongeneral.gov/cmh/childreport.htm LA - English DB - PAIS Index N1 - Date revised - 2006-09-28 N1 - Availability - U S Dept Health and Human Services N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - The Romanian Paremiologist Constantin Negreanu (1942-1991) AN - 54299273; 2001830791 JF - Proverbium: Yearbook of International Proverb Scholarship AU - Stănciulescu-Bârda, Alexandru PY - 2001 SP - 307 EP - 318 VL - 18 SN - 0743-782X, 0743-782X KW - folk literature KW - folk speech play KW - proverb KW - Romania KW - Negreanu, Constantin (1942-1991) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/54299273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amlaib&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proverbium%3A+Yearbook+of+International+Proverb+Scholarship&rft.atitle=The+Romanian+Paremiologist+Constantin+Negreanu+%281942-1991%29&rft.au=St%C4%83nciulescu-B%C3%A2rda%2C+Alexandru&rft.aulast=St%C4%83nciulescu-B%C3%A2rda&rft.aufirst=Alexandru&rft.date=2001-01-01&rft.volume=18&rft.issue=&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Proverbium%3A+Yearbook+of+International+Proverb+Scholarship&rft.issn=0743782X&rft_id=info:doi/ LA - English DB - MLA International Bibliography N1 - Update - 200101 N1 - Last updated - 2017-01-04 ER - TY - JOUR T1 - Geomechanics of reinforced cemented backfill in an underhand stope at the Lucky Friday Mine, Mullan, Idaho AN - 52165301; 2001-080108 AB - Because backfill has occasionally collapsed into an active working area, posing a hazard to miners, engineers from the Spokane Research Laboratory of the National Institute for Occupational Safety and Health and Hecla Mining Co. installed instruments in a cemented, backfilled, stope-ramp intersection at Hecla's Lucky Friday Mine, Mullan, ID. The purpose was to measure stress and strain changes in the backfill and reinforcing members during undercut mining. The instruments were monitored for 6 months while three successive cuts were mined below the intersection. Readings showed induced loads up to 3450 kPa (500 psi) in the backfill as stope walls converged 2.5 to 12 cm (1 to 5 in). The backfill then deformed against the top and bottom plates of the 2-m- (6-ft-) long vertical rock bolts installed as reinforcement, producing loads to 177 kN (40,000 lb) on the rock bolts. We hypothesize that a compressive zone was created in the backfill that allowed the backfill to remain stable as long as the compressive zones from adjacent rock bolts overlapped. This hypothesis is presented in graphical form. Of particular interest was the effect of loading on trusses installed to augment the vertical rock bolts and wire mesh typically installed in backfill. Data from the instruments indicate that wall closure perpendicular to the vein induced loads in truss legs parallel to the vein and in the rock bolt driven through the center of the truss, but, because they are designed to function under tension, truss legs perpendicular to the vein supplied insignificant support as a result of compressional forces from wall closure. Based on this study, use of trusses was discontinued, and an alternative support system of wood beams and posts was installed as needed to ensure the safety of miners working beneath the backfill in stope-ramp intersections. JF - Report of Investigations - NIOSH AU - Williams, T J AU - Denton, D K AU - Larson, M K AU - Rains, R L AU - Seymour, J B AU - Tesarik, D R Y1 - 2001 PY - 2001 DA - 2001 SP - 18 PB - U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Washington, D.C. KW - United States KW - backfill KW - mining KW - mines KW - Idaho KW - strain KW - loading KW - cement materials KW - stress KW - reinforced materials KW - mechanical properties KW - Lucky Friday Mine KW - rock mechanics KW - Shoshone County Idaho KW - Mullan Idaho KW - safety KW - mining geology KW - compression KW - construction materials KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52165301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Williams%2C+T+J%3BDenton%2C+D+K%3BLarson%2C+M+K%3BRains%2C+R+L%3BSeymour%2C+J+B%3BTesarik%2C+D+R&rft.aulast=Williams&rft.aufirst=T&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Geomechanics+of+reinforced+cemented+backfill+in+an+underhand+stope+at+the+Lucky+Friday+Mine%2C+Mullan%2C+Idaho&rft.title=Geomechanics+of+reinforced+cemented+backfill+in+an+underhand+stope+at+the+Lucky+Friday+Mine%2C+Mullan%2C+Idaho&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 16 N1 - PubXState - D.C. N1 - Document feature - illus. incl. 4 tables, sketch map N1 - SuppNotes - Includes appendix N1 - Last updated - 2012-06-07 N1 - CODEN - #05111 N1 - SubjectsTermNotLitGenreText - backfill; cement materials; compression; construction materials; Idaho; loading; Lucky Friday Mine; mechanical properties; mines; mining; mining geology; Mullan Idaho; reinforced materials; rock mechanics; safety; Shoshone County Idaho; strain; stress; United States ER - TY - JOUR T1 - Crack interaction with an interface in laminated elastic media AN - 52142734; 2002-019416 JF - Proceedings - Symposium on Rock Mechanics AU - Nuller, B AU - Ryvkin, M AU - Chudnovsky, A AU - Dudley, J W AU - Wong, G K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 289 EP - 296 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - petroleum engineering KW - cracks KW - reservoir properties KW - algorithms KW - elastic materials KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Crack+interaction+with+an+interface+in+laminated+elastic+media&rft.au=Nuller%2C+B%3BRyvkin%2C+M%3BChudnovsky%2C+A%3BDudley%2C+J+W%3BWong%2C+G+K&rft.aulast=Nuller&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=289&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; cracks; elastic materials; hydraulic fracturing; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics ER - TY - JOUR T1 - Hydraulic fracture containment in layered media, experiment and computer simulation AN - 52142688; 2002-019414 JF - Proceedings - Symposium on Rock Mechanics AU - Chudnovsky, A AU - Fan, J AU - Shulkin, Y AU - Dudley, J W AU - Nichols, W B AU - Wong, G K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 273 EP - 279 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - petroleum engineering KW - experimental studies KW - three-dimensional models KW - loading KW - data processing KW - simulation KW - layered materials KW - rock mechanics KW - reservoir rocks KW - cracks KW - reservoir properties KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Hydraulic+fracture+containment+in+layered+media%2C+experiment+and+computer+simulation&rft.au=Chudnovsky%2C+A%3BFan%2C+J%3BShulkin%2C+Y%3BDudley%2C+J+W%3BNichols%2C+W+B%3BWong%2C+G+K&rft.aulast=Chudnovsky&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=273&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; data processing; experimental studies; hydraulic fracturing; layered materials; loading; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; simulation; three-dimensional models ER - TY - JOUR T1 - Effect of pressurization rate and initial pore pressure on the magnitude of hydrofracturing breakdown pressure in tablerock sandstone AN - 52142646; 2002-019410 JF - Proceedings - Symposium on Rock Mechanics AU - Song, I AU - Haimson, B C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 235 EP - 242 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - petroleum engineering KW - pressure KW - sandstone KW - effects KW - rock mechanics KW - reservoir rocks KW - sedimentary rocks KW - pore pressure KW - reservoir properties KW - algorithms KW - clastic rocks KW - permeability KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Effect+of+pressurization+rate+and+initial+pore+pressure+on+the+magnitude+of+hydrofracturing+breakdown+pressure+in+tablerock+sandstone&rft.au=Song%2C+I%3BHaimson%2C+B+C&rft.aulast=Song&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=235&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; clastic rocks; effects; hydraulic fracturing; permeability; petroleum engineering; pore pressure; pressure; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks ER - TY - JOUR T1 - Modeling of the effect of well treatment on horizontal well casing deformation AN - 52142611; 2002-019397 JF - Proceedings - Symposium on Rock Mechanics AU - Chin, L Y AU - Nagel, N B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 133 EP - 139 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - finite element analysis KW - petroleum engineering KW - drawdown KW - loading KW - statistical analysis KW - reservoir properties KW - algorithms KW - deformation KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modeling+of+the+effect+of+well+treatment+on+horizontal+well+casing+deformation&rft.au=Chin%2C+L+Y%3BNagel%2C+N+B&rft.aulast=Chin&rft.aufirst=L&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=133&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; deformation; drawdown; finite element analysis; loading; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; statistical analysis ER - TY - JOUR T1 - Borehole collapse and sand production evaluation; experimental testing, analytical solutions and field implications AN - 52142572; 2002-019388 JF - Proceedings - Symposium on Rock Mechanics AU - Wang, Y AU - Wu, B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 67 EP - 74 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - experimental studies KW - strain KW - stability KW - sandstone KW - production KW - rock mechanics KW - reservoir rocks KW - sedimentary rocks KW - boreholes KW - elastoplastic materials KW - reservoir properties KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Borehole+collapse+and+sand+production+evaluation%3B+experimental+testing%2C+analytical+solutions+and+field+implications&rft.au=Wang%2C+Y%3BWu%2C+B&rft.aulast=Wang&rft.aufirst=Y&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=67&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; clastic rocks; elastoplastic materials; experimental studies; petroleum engineering; production; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks; stability; strain ER - TY - JOUR T1 - Development of stress measurements and instrument placement techniques for longwall coal AN - 52142380; 2002-019421 JF - Proceedings - Symposium on Rock Mechanics AU - Zahl, E G AU - Dunford, J P AU - Tesarik, D R AU - Larson, Mark K AU - Chen, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 327 EP - 335 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mining KW - mines KW - underground mining KW - roof control KW - stress KW - data processing KW - coal mines KW - simulation KW - rock mechanics KW - computer programs KW - safety KW - longwall mining KW - mining geology KW - instruments KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Development+of+stress+measurements+and+instrument+placement+techniques+for+longwall+coal&rft.au=Zahl%2C+E+G%3BDunford%2C+J+P%3BTesarik%2C+D+R%3BLarson%2C+Mark+K%3BChen%2C+J&rft.aulast=Zahl&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=327&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - coal mines; computer programs; data processing; instruments; longwall mining; mines; mining; mining engineering; mining geology; rock mechanics; roof control; safety; simulation; stress; underground mining ER - TY - JOUR T1 - Fracture mechanics in solutions of rock mechanics problems AN - 52142337; 2002-019418 JF - Proceedings - Symposium on Rock Mechanics AU - Zertsalov, M G AU - Yufin, S A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 307 EP - 312 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - fractures KW - petroleum engineering KW - cracks KW - reservoir properties KW - heterogeneity KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Fracture+mechanics+in+solutions+of+rock+mechanics+problems&rft.au=Zertsalov%2C+M+G%3BYufin%2C+S+A&rft.aulast=Zertsalov&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=307&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; fractures; heterogeneity; hydraulic fracturing; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics ER - TY - JOUR T1 - Pore pressure and fracture pressure analyses in non-consolidated rocks AN - 52142303; 2002-019394 JF - Proceedings - Symposium on Rock Mechanics AU - Syngaevsky, P E A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 115 EP - 119 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractured materials KW - petroleum engineering KW - prediction KW - salinity KW - Gulf of Mexico KW - rock mechanics KW - reservoir rocks KW - pore pressure KW - reservoir properties KW - unconsolidated materials KW - drilling KW - North Atlantic KW - faults KW - Atlantic Ocean KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Pore+pressure+and+fracture+pressure+analyses+in+non-consolidated+rocks&rft.au=Syngaevsky%2C+P+E&rft.aulast=Syngaevsky&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=115&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; drilling; faults; fractured materials; Gulf of Mexico; North Atlantic; petroleum engineering; pore pressure; prediction; reservoir properties; reservoir rocks; rock mechanics; salinity; unconsolidated materials ER - TY - JOUR T1 - Time dependent impact of water-based drilling fluids on shale properties AN - 52142256; 2002-019393 JF - Proceedings - Symposium on Rock Mechanics AU - Tare, U A AU - Mese, Ali I AU - Mody, F K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 107 EP - 112 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - strength KW - shale KW - stress KW - rock mechanics KW - reservoir rocks KW - sedimentary rocks KW - drilling muds KW - time factor KW - reservoir properties KW - drilling KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Time+dependent+impact+of+water-based+drilling+fluids+on+shale+properties&rft.au=Tare%2C+U+A%3BMese%2C+Ali+I%3BMody%2C+F+K&rft.aulast=Tare&rft.aufirst=U&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=107&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - clastic rocks; drilling; drilling muds; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; shale; strength; stress; time factor ER - TY - JOUR T1 - 38th U. S. rock mechanics symposium, DC rocks 2001 AN - 52142216; 2002-019379 JF - Proceedings - Symposium on Rock Mechanics A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 900 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - symposia KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=38th+U.+S.+rock+mechanics+symposium%2C+DC+rocks+2001&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - SuppNotes - Individual papers are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - rock mechanics; symposia ER - TY - JOUR T1 - A correlation between seismic tomography, seismic events and support pressure AN - 52142154; 2002-019420 JF - Proceedings - Symposium on Rock Mechanics AU - Westman, E C AU - Heasley, Keith A AU - Swanson, P L AU - Peterson, S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 319 EP - 326 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - tomography KW - mining engineering KW - mining KW - mines KW - failures KW - monitoring KW - pressure KW - underground mining KW - stress KW - geophysical methods KW - coal mines KW - production KW - seismic methods KW - rock mechanics KW - sedimentary rocks KW - longwall mining KW - mining geology KW - coal KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+correlation+between+seismic+tomography%2C+seismic+events+and+support+pressure&rft.au=Westman%2C+E+C%3BHeasley%2C+Keith+A%3BSwanson%2C+P+L%3BPeterson%2C+S&rft.aulast=Westman&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=319&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 22 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - coal; coal mines; failures; geophysical methods; longwall mining; mines; mining; mining engineering; mining geology; monitoring; pressure; production; rock mechanics; sedimentary rocks; seismic methods; stress; tomography; underground mining ER - TY - JOUR T1 - Numerical modeling of the coupling between mechanical and hydraulic properties in a granite rock mass subject to high-pressure injection experiments AN - 52142110; 2002-019413 JF - Proceedings - Symposium on Rock Mechanics AU - Bruel, D AU - Jeong, W C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 261 EP - 269 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - petroleum engineering KW - experimental studies KW - pressure KW - numerical models KW - igneous rocks KW - granites KW - coupling KW - high pressure KW - rock mechanics KW - reservoir rocks KW - fluid injection KW - plutonic rocks KW - boreholes KW - pore pressure KW - reservoir properties KW - algorithms KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Numerical+modeling+of+the+coupling+between+mechanical+and+hydraulic+properties+in+a+granite+rock+mass+subject+to+high-pressure+injection+experiments&rft.au=Bruel%2C+D%3BJeong%2C+W+C&rft.aulast=Bruel&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=261&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; boreholes; coupling; experimental studies; fluid injection; granites; high pressure; hydraulic fracturing; igneous rocks; numerical models; petroleum engineering; plutonic rocks; pore pressure; pressure; reservoir properties; reservoir rocks; rock mechanics ER - TY - JOUR T1 - Grain bonding and its effect on borehole breakout formation and final shape AN - 52142072; 2002-019386 JF - Proceedings - Symposium on Rock Mechanics AU - Klaetsch, A R AU - Haimson, B C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 53 EP - 58 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - failures KW - petroleum engineering KW - experimental studies KW - borehole breakouts KW - Paleozoic KW - Middle Ordovician KW - stress KW - sandstone KW - bonding KW - rock mechanics KW - reservoir rocks KW - Ordovician KW - laboratory studies KW - sedimentary rocks KW - reservoir properties KW - algorithms KW - Saint Peter Sandstone KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Grain+bonding+and+its+effect+on+borehole+breakout+formation+and+final+shape&rft.au=Klaetsch%2C+A+R%3BHaimson%2C+B+C&rft.aulast=Klaetsch&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=53&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; bonding; borehole breakouts; clastic rocks; experimental studies; failures; laboratory studies; Middle Ordovician; Ordovician; Paleozoic; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; Saint Peter Sandstone; sandstone; sedimentary rocks; stress ER - TY - JOUR T1 - One-way coupled reservoir; geomechanical modeling of the Lost Hills oil field, California AN - 52141912; 2002-019403 JF - Proceedings - Symposium on Rock Mechanics AU - Fredrich, J T AU - Holland, J F AU - Fossum, A F AU - Bruno, M S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 181 EP - 188 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - petroleum engineering KW - data processing KW - petroleum KW - simulation KW - oil and gas fields KW - rock mechanics KW - reservoir rocks KW - compaction KW - California KW - Kern County California KW - fluid injection KW - data bases KW - reservoir properties KW - Lost Hills Field KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52141912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=One-way+coupled+reservoir%3B+geomechanical+modeling+of+the+Lost+Hills+oil+field%2C+California&rft.au=Fredrich%2C+J+T%3BHolland%2C+J+F%3BFossum%2C+A+F%3BBruno%2C+M+S&rft.aulast=Fredrich&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=181&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - California; compaction; data bases; data processing; fluid injection; Kern County California; Lost Hills Field; oil and gas fields; petroleum; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; simulation; United States ER - TY - JOUR T1 - Effect of water-cut on sandstone strength and implications in sand production prediction AN - 52141866; 2002-019383 JF - Proceedings - Symposium on Rock Mechanics AU - Wu, B AU - Tan, C P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 27 EP - 34 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - sedimentary rocks KW - saturation KW - strength KW - sandstone KW - prediction KW - reservoir properties KW - production KW - clastic rocks KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52141866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Effect+of+water-cut+on+sandstone+strength+and+implications+in+sand+production+prediction&rft.au=Wu%2C+B%3BTan%2C+C+P&rft.aulast=Wu&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=27&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 23 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - clastic rocks; petroleum engineering; prediction; production; reservoir properties; reservoir rocks; rock mechanics; sandstone; saturation; sedimentary rocks; strength ER - TY - JOUR T1 - Poroelastic chemical and thermal effects on wellbore stability in shales AN - 52141817; 2002-019381 JF - Proceedings - Symposium on Rock Mechanics AU - Chen, G AU - Chenevert, M E AU - Sharma, M M AU - Yu, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 11 EP - 18 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - elasticity KW - shale KW - poroelasticity KW - stress KW - stability KW - effects KW - chemical effects KW - rock mechanics KW - sedimentary rocks KW - reservoir properties KW - drilling KW - algorithms KW - thermal effects KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52141817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Poroelastic+chemical+and+thermal+effects+on+wellbore+stability+in+shales&rft.au=Chen%2C+G%3BChenevert%2C+M+E%3BSharma%2C+M+M%3BYu%2C+M&rft.aulast=Chen&rft.aufirst=G&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=11&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 32 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; chemical effects; clastic rocks; drilling; effects; elasticity; petroleum engineering; poroelasticity; reservoir properties; rock mechanics; sedimentary rocks; shale; stability; stress; thermal effects ER - TY - JOUR T1 - Single and multiphase flow through fractured porous media AN - 52140654; 2002-019407 JF - Proceedings - Symposium on Rock Mechanics AU - Bogdanov, I AU - Adler, P AU - Mourzenko, V AU - Thovert, J F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 211 EP - 218 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractured materials KW - petroleum engineering KW - reservoir properties KW - porous materials KW - algorithms KW - fluid dynamics KW - simulation KW - permeability KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52140654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Single+and+multiphase+flow+through+fractured+porous+media&rft.au=Bogdanov%2C+I%3BAdler%2C+P%3BMourzenko%2C+V%3BThovert%2C+J+F&rft.aulast=Bogdanov&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=211&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; fluid dynamics; fractured materials; permeability; petroleum engineering; porous materials; reservoir properties; reservoir rocks; rock mechanics; simulation ER - TY - JOUR T1 - A more realistic sand production prediction using pore collapse theory AN - 52140618; 2002-019384 JF - Proceedings - Symposium on Rock Mechanics AU - Awal, M R AU - Azeemuddin, M AU - Khan, M S AU - Abdulraheem, A AU - Mohiuddin, M A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 35 EP - 42 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - failures KW - petroleum engineering KW - Paleozoic KW - stress KW - stability KW - sandstone KW - prediction KW - production KW - porosity KW - rock mechanics KW - reservoir rocks KW - case studies KW - Lower Devonian KW - sedimentary rocks KW - Devonian KW - reservoir properties KW - algorithms KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52140618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+more+realistic+sand+production+prediction+using+pore+collapse+theory&rft.au=Awal%2C+M+R%3BAzeemuddin%2C+M%3BKhan%2C+M+S%3BAbdulraheem%2C+A%3BMohiuddin%2C+M+A&rft.aulast=Awal&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=35&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; case studies; clastic rocks; Devonian; failures; Lower Devonian; Paleozoic; petroleum engineering; porosity; prediction; production; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks; stability; stress ER - TY - JOUR T1 - Influence of perforations and inhomogeneity on the mode and magnitude of sand production AN - 52140591; 2002-019382 JF - Proceedings - Symposium on Rock Mechanics AU - Vaziri, H H AU - Palmer, I AU - Lemoine, E AU - Islam, R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 19 EP - 26 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - sandstone KW - optimization KW - production KW - rock mechanics KW - reservoir rocks KW - sedimentary rocks KW - centrifuge methods KW - reservoir properties KW - algorithms KW - heterogeneity KW - clastic rocks KW - permeability KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52140591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Influence+of+perforations+and+inhomogeneity+on+the+mode+and+magnitude+of+sand+production&rft.au=Vaziri%2C+H+H%3BPalmer%2C+I%3BLemoine%2C+E%3BIslam%2C+R&rft.aulast=Vaziri&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=19&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; centrifuge methods; clastic rocks; heterogeneity; optimization; permeability; petroleum engineering; production; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks ER - TY - JOUR T1 - Improvements in blast fragmentation models using digital image processing AN - 52139861; 2002-019426 JF - Proceedings - Symposium on Rock Mechanics AU - Kemeny, J M AU - Mofya, E AU - Kaunda, R AU - Perry, G AU - Morin, B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 361 EP - 367 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - computer programs KW - mining KW - imagery KW - fragmentation KW - blasting KW - mining geology KW - digital simulation KW - data processing KW - algorithms KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Improvements+in+blast+fragmentation+models+using+digital+image+processing&rft.au=Kemeny%2C+J+M%3BMofya%2C+E%3BKaunda%2C+R%3BPerry%2C+G%3BMorin%2C+B&rft.aulast=Kemeny&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=361&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 17 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; blasting; computer programs; data processing; digital simulation; fragmentation; imagery; mining; mining geology; models; rock mechanics ER - TY - JOUR T1 - A mechanistic study of coal and gas outbursts AN - 52139828; 2002-019423 JF - Proceedings - Symposium on Rock Mechanics AU - Choi, S K AU - Wold, M B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 343 EP - 350 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mines KW - geologic hazards KW - Australasia KW - natural gas KW - coal mines KW - New South Wales Australia KW - joints KW - coupling KW - petroleum KW - coal seams KW - deformation KW - rock mechanics KW - reservoir rocks KW - fractures KW - style KW - rock bursts KW - pore pressure KW - Queensland Australia KW - Australia KW - blowouts KW - faults KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+mechanistic+study+of+coal+and+gas+outbursts&rft.au=Choi%2C+S+K%3BWold%2C+M+B&rft.aulast=Choi&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=343&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Australasia; Australia; blowouts; coal mines; coal seams; coupling; deformation; faults; fractures; geologic hazards; joints; mines; mining engineering; natural gas; New South Wales Australia; petroleum; pore pressure; Queensland Australia; reservoir rocks; rock bursts; rock mechanics; style ER - TY - JOUR T1 - Simulation of hydraulic fracturing using an explicit moving mesh algorithm AN - 52139786; 2002-019411 JF - Proceedings - Symposium on Rock Mechanics AU - Adachi, Jose I AU - Detournay, Emmanuel AU - Savitski, Alexei A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 243 EP - 250 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - petroleum engineering KW - strain KW - finite difference analysis KW - statistical analysis KW - data processing KW - reservoir properties KW - algorithms KW - simulation KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Simulation+of+hydraulic+fracturing+using+an+explicit+moving+mesh+algorithm&rft.au=Adachi%2C+Jose+I%3BDetournay%2C+Emmanuel%3BSavitski%2C+Alexei+A&rft.aulast=Adachi&rft.aufirst=Jose&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=243&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; data processing; finite difference analysis; hydraulic fracturing; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; simulation; statistical analysis; strain ER - TY - JOUR T1 - Water distribution; a key factor to characterize shale AN - 52139737; 2002-019392 JF - Proceedings - Symposium on Rock Mechanics AU - Diaz, A P AU - Roegiers, J C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 99 EP - 106 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - clay KW - petroleum engineering KW - X-ray diffraction data KW - clastic sediments KW - shale KW - rock mechanics KW - reservoir rocks KW - ground water KW - sedimentary rocks KW - boreholes KW - sediments KW - reservoir properties KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Water+distribution%3B+a+key+factor+to+characterize+shale&rft.au=Diaz%2C+A+P%3BRoegiers%2C+J+C&rft.aulast=Diaz&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=99&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 19 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; clastic rocks; clastic sediments; clay; ground water; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; sediments; shale; X-ray diffraction data ER - TY - JOUR T1 - Effects of ion transfer on stress and pore pressure distributions around a borehole in shale AN - 52139692; 2002-019390 JF - Proceedings - Symposium on Rock Mechanics AU - Ghassemi, A AU - Diek, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 85 EP - 91 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - elasticity KW - shale KW - poroelasticity KW - stress KW - optimization KW - ion transfer KW - deformation KW - ions KW - rock mechanics KW - reservoir rocks KW - sedimentary rocks KW - boreholes KW - pore pressure KW - reservoir properties KW - algorithms KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Effects+of+ion+transfer+on+stress+and+pore+pressure+distributions+around+a+borehole+in+shale&rft.au=Ghassemi%2C+A%3BDiek%2C+A&rft.aulast=Ghassemi&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=85&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 19 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; boreholes; clastic rocks; deformation; elasticity; ion transfer; ions; optimization; petroleum engineering; pore pressure; poroelasticity; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; shale; stress ER - TY - JOUR T1 - Prediction of different types of cavity failure using bifurcation theory AN - 52139649; 2002-019385 JF - Proceedings - Symposium on Rock Mechanics AU - van den Hoek, P J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 45 EP - 52 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - failures KW - petroleum engineering KW - loading KW - stress KW - stability KW - prediction KW - reservoir properties KW - algorithms KW - bifurcation KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Prediction+of+different+types+of+cavity+failure+using+bifurcation+theory&rft.au=van+den+Hoek%2C+P+J&rft.aulast=van+den+Hoek&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=45&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 17 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; bifurcation; failures; loading; petroleum engineering; prediction; reservoir properties; reservoir rocks; rock mechanics; stability; stress ER - TY - JOUR T1 - Supporting mechanism of roadway driven along next goaf in fully mechanized top coal caving face AN - 52139639; 2002-019425 JF - Proceedings - Symposium on Rock Mechanics AU - Bai, Jianbiao AU - Li, Xuehua AU - Li, Haiyan A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 355 EP - 358 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mining KW - mines KW - strength KW - roof control KW - stress KW - coal mines KW - coal seams KW - rock mechanics KW - goaf KW - safety KW - mining geology KW - roads KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Supporting+mechanism+of+roadway+driven+along+next+goaf+in+fully+mechanized+top+coal+caving+face&rft.au=Bai%2C+Jianbiao%3BLi%2C+Xuehua%3BLi%2C+Haiyan&rft.aulast=Bai&rft.aufirst=Jianbiao&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=355&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - coal mines; coal seams; goaf; mines; mining; mining engineering; mining geology; roads; rock mechanics; roof control; safety; strength; stress ER - TY - JOUR T1 - Evaluation and re-dimensioning of room and pillar workings in an underground gypsum mine AN - 52139609; 2002-019422 JF - Proceedings - Symposium on Rock Mechanics AU - Siefert, Matthias AU - Wagner, Horst A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 337 EP - 342 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mining KW - underground mining KW - Europe KW - Austria KW - rock mechanics KW - mining geology KW - Central Europe KW - room-and-pillar mining KW - gypsum deposits KW - design KW - pillars KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Evaluation+and+re-dimensioning+of+room+and+pillar+workings+in+an+underground+gypsum+mine&rft.au=Siefert%2C+Matthias%3BWagner%2C+Horst&rft.aulast=Siefert&rft.aufirst=Matthias&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=337&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Austria; Central Europe; design; Europe; gypsum deposits; mining; mining engineering; mining geology; pillars; rock mechanics; room-and-pillar mining; underground mining ER - TY - JOUR T1 - Modeling of packer influence on hydraulic fracture initiation in laboratory tests AN - 52139561; 2002-019408 JF - Proceedings - Symposium on Rock Mechanics AU - Zeng, Z W AU - Roegiers, J C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 221 EP - 225 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - petroleum engineering KW - experimental studies KW - sandstone KW - packers KW - rock mechanics KW - reservoir rocks KW - laboratory studies KW - fractures KW - sedimentary rocks KW - boreholes KW - discretization KW - reservoir properties KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modeling+of+packer+influence+on+hydraulic+fracture+initiation+in+laboratory+tests&rft.au=Zeng%2C+Z+W%3BRoegiers%2C+J+C&rft.aulast=Zeng&rft.aufirst=Z&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=221&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; clastic rocks; discretization; experimental studies; fractures; hydraulic fracturing; laboratory studies; packers; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks ER - TY - JOUR T1 - Influence of pore wall roughness on the slaking of shales AN - 52139526; 2002-019391 JF - Proceedings - Symposium on Rock Mechanics AU - Vallejo, L E AU - Stewart-Murphy, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 93 EP - 98 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - silicates KW - mining KW - embankments KW - petroleum engineering KW - Appalachians KW - rock mechanics KW - reservoir rocks KW - sedimentary rocks KW - mining geology KW - Tennessee KW - fractals KW - West Virginia KW - North America KW - Virginia KW - shale KW - roughness KW - kaolinite KW - porosity KW - clay minerals KW - Kentucky KW - sheet silicates KW - reservoir properties KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Influence+of+pore+wall+roughness+on+the+slaking+of+shales&rft.au=Vallejo%2C+L+E%3BStewart-Murphy%2C+A&rft.aulast=Vallejo&rft.aufirst=L&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=93&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Appalachians; clastic rocks; clay minerals; embankments; fractals; kaolinite; Kentucky; mining; mining geology; North America; petroleum engineering; porosity; reservoir properties; reservoir rocks; rock mechanics; roughness; sedimentary rocks; shale; sheet silicates; silicates; Tennessee; United States; Virginia; West Virginia ER - TY - JOUR T1 - Coupled particle and fluid flow modeling of fracture and slurry injection in weakly consolidated granular media AN - 52139453; 2002-019402 JF - Proceedings - Symposium on Rock Mechanics AU - Bruno, M S AU - Dorfmann, A AU - Lao, K AU - Honeger, C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 173 EP - 180 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractured materials KW - mining KW - petroleum engineering KW - fluid dynamics KW - rock mechanics KW - reservoir rocks KW - models KW - fluid injection KW - granular materials KW - mining geology KW - slurries KW - reservoir properties KW - algorithms KW - consolidation KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Coupled+particle+and+fluid+flow+modeling+of+fracture+and+slurry+injection+in+weakly+consolidated+granular+media&rft.au=Bruno%2C+M+S%3BDorfmann%2C+A%3BLao%2C+K%3BHoneger%2C+C&rft.aulast=Bruno&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=173&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; consolidation; fluid dynamics; fluid injection; fractured materials; granular materials; mining; mining geology; models; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; slurries ER - TY - JOUR T1 - Production-induced normal faulting AN - 52139380; 2002-019400 JF - Proceedings - Symposium on Rock Mechanics AU - Zoback, M D AU - Chan, A W AU - Zinke, J C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 157 EP - 163 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - Cretaceous KW - stress KW - Ekofisk Field KW - petroleum KW - displacements KW - Valhall Field KW - oil and gas fields KW - Mesozoic KW - rock mechanics KW - reservoir rocks KW - pore pressure KW - normal faults KW - reservoir properties KW - algorithms KW - North Sea KW - North Atlantic KW - faults KW - Atlantic Ocean KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Production-induced+normal+faulting&rft.au=Zoback%2C+M+D%3BChan%2C+A+W%3BZinke%2C+J+C&rft.aulast=Zoback&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=157&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 28 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; Atlantic Ocean; Cretaceous; displacements; Ekofisk Field; faults; Mesozoic; normal faults; North Atlantic; North Sea; oil and gas fields; petroleum; petroleum engineering; pore pressure; reservoir properties; reservoir rocks; rock mechanics; stress; Valhall Field ER - TY - JOUR T1 - Numerical simulation of damage and fracture in heterogeneous rocks AN - 52139057; 2002-019419 JF - Proceedings - Symposium on Rock Mechanics AU - Mishnaevsky, Leon L, Jr A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 313 EP - 316 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - petroleum engineering KW - cracks KW - numerical models KW - heterogeneous materials KW - reservoir properties KW - simulation KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52139057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Numerical+simulation+of+damage+and+fracture+in+heterogeneous+rocks&rft.au=Mishnaevsky%2C+Leon+L%2C+Jr&rft.aulast=Mishnaevsky&rft.aufirst=Leon&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=313&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; fractures; heterogeneous materials; numerical models; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; simulation ER - TY - JOUR T1 - Impact of stress-dependent Young's moduli on hydraulic fracture modeling AN - 52138600; 2002-019417 JF - Proceedings - Symposium on Rock Mechanics AU - Meyer, B R AU - Jacot, R H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 297 EP - 306 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - fractures KW - petroleum engineering KW - stress KW - reservoir properties KW - elastic constants KW - algorithms KW - Young's modulus KW - two-dimensional models KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Impact+of+stress-dependent+Young%27s+moduli+on+hydraulic+fracture+modeling&rft.au=Meyer%2C+B+R%3BJacot%2C+R+H&rft.aulast=Meyer&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=297&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 26 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; elastic constants; fractures; hydraulic fracturing; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; stress; two-dimensional models; Young's modulus ER - TY - JOUR T1 - Two-phase flow in porous media; extending pore-scale mechanics to geologic displacement processes AN - 52138572; 2002-019405 JF - Proceedings - Symposium on Rock Mechanics AU - Strand, T E AU - Wang, H F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 197 EP - 204 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - reservoir properties KW - porous materials KW - percolation KW - fluid dynamics KW - displacements KW - two-dimensional models KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Two-phase+flow+in+porous+media%3B+extending+pore-scale+mechanics+to+geologic+displacement+processes&rft.au=Strand%2C+T+E%3BWang%2C+H+F&rft.aulast=Strand&rft.aufirst=T&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=197&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - displacements; fluid dynamics; percolation; petroleum engineering; porous materials; reservoir properties; reservoir rocks; rock mechanics; two-dimensional models ER - TY - JOUR T1 - Propagation of a penny-shaped hydraulic fracture parallel to a free surface, with application to inducing rock mass caving for mining AN - 52138568; 2002-019415 JF - Proceedings - Symposium on Rock Mechanics AU - Zhang, Xi AU - Detournay, Emmanuel AU - Jeffrey, Rob G A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 281 EP - 288 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - mining KW - failures KW - petroleum engineering KW - stability KW - simulation KW - rock mechanics KW - reservoir rocks KW - fractures KW - fluid injection KW - mining geology KW - reservoir properties KW - algorithms KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Propagation+of+a+penny-shaped+hydraulic+fracture+parallel+to+a+free+surface%2C+with+application+to+inducing+rock+mass+caving+for+mining&rft.au=Zhang%2C+Xi%3BDetournay%2C+Emmanuel%3BJeffrey%2C+Rob+G&rft.aulast=Zhang&rft.aufirst=Xi&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=281&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; failures; fluid injection; fractures; hydraulic fracturing; mining; mining geology; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; simulation; stability ER - TY - JOUR T1 - Mechanical behaviour of reservoir grain framework and pore characteristics; semi-quantitative predictions using microprobe combined with image analysis AN - 52138538; 2002-019399 JF - Proceedings - Symposium on Rock Mechanics AU - Wolf, K H A A AU - Ephraim, R AU - Schutjens, P M T M AU - Imperiale, P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 147 EP - 154 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractured materials KW - petroleum engineering KW - Jurassic KW - stability KW - prediction KW - porosity KW - Mesozoic KW - rock mechanics KW - reservoir rocks KW - electron probe data KW - granular materials KW - quantitative analysis KW - Triassic KW - reservoir properties KW - North Sea KW - North Atlantic KW - image analysis KW - Atlantic Ocean KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Mechanical+behaviour+of+reservoir+grain+framework+and+pore+characteristics%3B+semi-quantitative+predictions+using+microprobe+combined+with+image+analysis&rft.au=Wolf%2C+K+H+A+A%3BEphraim%2C+R%3BSchutjens%2C+P+M+T+M%3BImperiale%2C+P&rft.aulast=Wolf&rft.aufirst=K+H+A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=147&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; electron probe data; fractured materials; granular materials; image analysis; Jurassic; Mesozoic; North Atlantic; North Sea; petroleum engineering; porosity; prediction; quantitative analysis; reservoir properties; reservoir rocks; rock mechanics; stability; Triassic ER - TY - JOUR T1 - Disposal of drill cuttings; determining the properties of unconsolidated sandstones and clayey sands AN - 52138534; 2002-019396 JF - Proceedings - Symposium on Rock Mechanics AU - Dvorkin, Jack AU - Mese, Ali I AU - Soliman, Mohamed A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 129 EP - 132 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - experimental studies KW - strain KW - sandstone KW - rock mechanics KW - reservoir rocks KW - compaction KW - sedimentary rocks KW - claystone KW - reservoir properties KW - unconsolidated materials KW - drilling KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Disposal+of+drill+cuttings%3B+determining+the+properties+of+unconsolidated+sandstones+and+clayey+sands&rft.au=Dvorkin%2C+Jack%3BMese%2C+Ali+I%3BSoliman%2C+Mohamed&rft.aulast=Dvorkin&rft.aufirst=Jack&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=129&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - clastic rocks; claystone; compaction; drilling; experimental studies; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks; strain; unconsolidated materials ER - TY - JOUR T1 - Water weakening in sedimentary rocks AN - 52138505; 2002-019395 JF - Proceedings - Symposium on Rock Mechanics AU - Rhett, D W AU - Lord, C J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 121 EP - 128 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - experimental studies KW - strength KW - siliciclastics KW - rock mechanics KW - reservoir rocks KW - chalk KW - fluid injection KW - sedimentary rocks KW - reservoir properties KW - North Sea KW - North Atlantic KW - compression KW - carbonate rocks KW - clastic rocks KW - Atlantic Ocean KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Water+weakening+in+sedimentary+rocks&rft.au=Rhett%2C+D+W%3BLord%2C+C+J&rft.aulast=Rhett&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=121&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; carbonate rocks; chalk; clastic rocks; compression; experimental studies; fluid injection; North Atlantic; North Sea; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; siliciclastics; strength ER - TY - JOUR T1 - Development and application of a strength and damage model for rock under dynamic loading AN - 52138503; 2002-019427 JF - Proceedings - Symposium on Rock Mechanics AU - Antoun, Tarabay H AU - Lomov, Ilya N AU - Glenn, Lewis A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 369 EP - 374 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - mining KW - underground storage KW - explosions KW - strength KW - loading KW - igneous rocks KW - granites KW - damage KW - displacements KW - simulation KW - rock mechanics KW - Nevada Test Site KW - plutonic rocks KW - blasting KW - mining geology KW - underground installations KW - algorithms KW - nuclear explosions KW - Nevada KW - faults KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Development+and+application+of+a+strength+and+damage+model+for+rock+under+dynamic+loading&rft.au=Antoun%2C+Tarabay+H%3BLomov%2C+Ilya+N%3BGlenn%2C+Lewis+A&rft.aulast=Antoun&rft.aufirst=Tarabay&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=369&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 5 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; blasting; damage; displacements; explosions; faults; granites; igneous rocks; loading; mining; mining geology; Nevada; Nevada Test Site; nuclear explosions; plutonic rocks; rock mechanics; simulation; strength; underground installations; underground storage; United States ER - TY - JOUR T1 - Development and use of a high pressure packer for measuring horizontal stress using the hydraulic fracturing method AN - 52138471; 2002-019409 JF - Proceedings - Symposium on Rock Mechanics AU - Oyler, D C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 227 EP - 234 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - mining KW - petroleum engineering KW - pressure KW - underground mining KW - stress KW - packers KW - high pressure KW - rock mechanics KW - reservoir rocks KW - safety KW - mining geology KW - reservoir properties KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Development+and+use+of+a+high+pressure+packer+for+measuring+horizontal+stress+using+the+hydraulic+fracturing+method&rft.au=Oyler%2C+D+C&rft.aulast=Oyler&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=227&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - high pressure; hydraulic fracturing; mining; mining geology; packers; petroleum engineering; pressure; reservoir properties; reservoir rocks; rock mechanics; safety; stress; underground mining ER - TY - JOUR T1 - Simulation of immiscible viscous displacement within the plane of a horizontal fracture AN - 52138431; 2002-019406 JF - Proceedings - Symposium on Rock Mechanics AU - Nicholl, M J AU - Glass, R J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 205 EP - 210 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - fractures KW - petroleum engineering KW - diffusion KW - viscous materials KW - reservoir properties KW - percolation KW - displacements KW - simulation KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Simulation+of+immiscible+viscous+displacement+within+the+plane+of+a+horizontal+fracture&rft.au=Nicholl%2C+M+J%3BGlass%2C+R+J&rft.aulast=Nicholl&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=205&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - diffusion; displacements; fractures; models; percolation; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; simulation; viscous materials ER - TY - JOUR T1 - Extensional wave attenuation and velocity in partially-saturated sand in the sonic frequency range AN - 52138389; 2002-019398 JF - Proceedings - Symposium on Rock Mechanics AU - Liu, Z AU - Rector, J W AU - Nihei, K T AU - Tomutsa, L AU - Myer, L R AU - Nakagawa, S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 141 EP - 145 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - experimental studies KW - saturated materials KW - sandstone KW - production KW - rock mechanics KW - reservoir rocks KW - attenuation KW - sedimentary rocks KW - velocity KW - reservoir properties KW - propagation KW - clastic rocks KW - permeability KW - acoustical waves KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Extensional+wave+attenuation+and+velocity+in+partially-saturated+sand+in+the+sonic+frequency+range&rft.au=Liu%2C+Z%3BRector%2C+J+W%3BNihei%2C+K+T%3BTomutsa%2C+L%3BMyer%2C+L+R%3BNakagawa%2C+S&rft.aulast=Liu&rft.aufirst=Z&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=141&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical waves; attenuation; clastic rocks; experimental studies; permeability; petroleum engineering; production; propagation; reservoir properties; reservoir rocks; rock mechanics; sandstone; saturated materials; sedimentary rocks; velocity ER - TY - JOUR T1 - Behavior of a reactive shale from 12000 feet depth AN - 52138366; 2002-019389 JF - Proceedings - Symposium on Rock Mechanics AU - Ewy, R T AU - Daniels, E J AU - Stankovich, R J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 77 EP - 84 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - clay KW - petroleum engineering KW - strain KW - Cretaceous KW - clastic sediments KW - shale KW - petroleum KW - oil and gas fields KW - Mesozoic KW - rock mechanics KW - reservoir rocks KW - Britannia Field KW - sedimentary rocks KW - boreholes KW - sediments KW - reservoir properties KW - North Sea KW - North Atlantic KW - clastic rocks KW - Atlantic Ocean KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Behavior+of+a+reactive+shale+from+12000+feet+depth&rft.au=Ewy%2C+R+T%3BDaniels%2C+E+J%3BStankovich%2C+R+J&rft.aulast=Ewy&rft.aufirst=R&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=77&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; boreholes; Britannia Field; clastic rocks; clastic sediments; clay; Cretaceous; Mesozoic; North Atlantic; North Sea; oil and gas fields; petroleum; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; sediments; shale; strain ER - TY - JOUR T1 - Mechanical and acoustic properties of weakly cemented granular rocks AN - 52138329; 2002-019380 JF - Proceedings - Symposium on Rock Mechanics AU - Nakagawa, S AU - Myer, L R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 3 EP - 10 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractured materials KW - failures KW - petroleum engineering KW - acoustical properties KW - borehole breakouts KW - cementation KW - mechanical properties KW - excavations KW - rock mechanics KW - reservoir rocks KW - granular materials KW - diagenesis KW - reservoir properties KW - drilling KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52138329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Mechanical+and+acoustic+properties+of+weakly+cemented+granular+rocks&rft.au=Nakagawa%2C+S%3BMyer%2C+L+R&rft.aulast=Nakagawa&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=3&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical properties; borehole breakouts; cementation; diagenesis; drilling; excavations; failures; fractured materials; granular materials; mechanical properties; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics ER - TY - JOUR T1 - A preliminary study of the relationship between two-phase flow (airwater) characteristics and fracture roughness AN - 52137103; 2002-019404 JF - Proceedings - Symposium on Rock Mechanics AU - Indraratna, B N AU - Ranjith, P G AU - Price, J R AU - Gale, W A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 191 EP - 196 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - pressure KW - roughness KW - fluid dynamics KW - excavations KW - rock mechanics KW - reservoir rocks KW - models KW - fractures KW - steady-state processes KW - reservoir properties KW - unconformities KW - algorithms KW - permeability KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52137103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+preliminary+study+of+the+relationship+between+two-phase+flow+%28airwater%29+characteristics+and+fracture+roughness&rft.au=Indraratna%2C+B+N%3BRanjith%2C+P+G%3BPrice%2C+J+R%3BGale%2C+W&rft.aulast=Indraratna&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=191&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 23 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; excavations; fluid dynamics; fractures; models; permeability; petroleum engineering; pressure; reservoir properties; reservoir rocks; rock mechanics; roughness; steady-state processes; unconformities ER - TY - JOUR T1 - Simulation of flow in sandstone with fluid coupled particle model AN - 52137065; 2002-019401 JF - Proceedings - Symposium on Rock Mechanics AU - Li, L AU - Holt, R M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 165 EP - 172 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - stress KW - sandstone KW - fluid dynamics KW - simulation KW - rock mechanics KW - reservoir rocks KW - models KW - fluid injection KW - sedimentary rocks KW - reservoir properties KW - algorithms KW - clastic rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52137065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Simulation+of+flow+in+sandstone+with+fluid+coupled+particle+model&rft.au=Li%2C+L%3BHolt%2C+R+M&rft.aulast=Li&rft.aufirst=L&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=165&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; clastic rocks; fluid dynamics; fluid injection; models; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; sandstone; sedimentary rocks; simulation; stress ER - TY - JOUR T1 - Wellbore behaviour in fractured rock masses AN - 52137041; 2002-019387 JF - Proceedings - Symposium on Rock Mechanics AU - Chen, X AU - Tan, C P AU - Detournay, C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 59 EP - 66 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractured materials KW - petroleum engineering KW - boreholes KW - reservoir properties KW - drilling KW - two-dimensional models KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52137041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Wellbore+behaviour+in+fractured+rock+masses&rft.au=Chen%2C+X%3BTan%2C+C+P%3BDetournay%2C+C&rft.aulast=Chen&rft.aufirst=X&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=59&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 7 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; drilling; fractured materials; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; two-dimensional models ER - TY - JOUR T1 - In-plane analysis of fracture surface roughness; anisotropy and scale effect in anisotropy AN - 52121810; 2002-019480 JF - Proceedings - Symposium on Rock Mechanics AU - Rasouli, V AU - Harrison, J P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 777 EP - 783 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - scale factor KW - fractures KW - multivariate analysis KW - statistical analysis KW - roughness KW - anisotropy KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52121810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=In-plane+analysis+of+fracture+surface+roughness%3B+anisotropy+and+scale+effect+in+anisotropy&rft.au=Rasouli%2C+V%3BHarrison%2C+J+P&rft.aulast=Rasouli&rft.aufirst=V&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=777&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 22 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - anisotropy; fractures; multivariate analysis; rock mechanics; roughness; scale factor; statistical analysis ER - TY - JOUR T1 - A methodology for validation of process models used to simulate thermal tests at Yucca Mountain AN - 52121770; 2002-019461 JF - Proceedings - Symposium on Rock Mechanics AU - Wagner, R A AU - Ballard, S AU - Blair, Stephen C AU - Mukhopadhyay, S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 631 EP - 636 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - thermal properties KW - simulation KW - Nye County Nevada KW - temperature KW - rock mechanics KW - radioactive waste KW - models KW - underground installations KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52121770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+methodology+for+validation+of+process+models+used+to+simulate+thermal+tests+at+Yucca+Mountain&rft.au=Wagner%2C+R+A%3BBallard%2C+S%3BBlair%2C+Stephen+C%3BMukhopadhyay%2C+S&rft.aulast=Wagner&rft.aufirst=R&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=631&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 7 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - models; Nevada; Nye County Nevada; radioactive waste; rock mechanics; simulation; temperature; thermal properties; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Ventilation test for repository subsurface design AN - 52121743; 2002-019454 JF - Proceedings - Symposium on Rock Mechanics AU - Sun, Yiming AU - Jurani, Romeo AU - Yang, Hang A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 575 EP - 582 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - Nye County Nevada KW - rock mechanics KW - radioactive waste KW - ventilation KW - safety KW - underground installations KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52121743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Ventilation+test+for+repository+subsurface+design&rft.au=Sun%2C+Yiming%3BJurani%2C+Romeo%3BYang%2C+Hang&rft.aulast=Sun&rft.aufirst=Yiming&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=575&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; Nevada; Nye County Nevada; radioactive waste; rock mechanics; safety; underground disposal; underground installations; United States; ventilation; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Optimization of the contour blasting during rock slope excavation at the Three Gorges Project AN - 52121705; 2002-019430 JF - Proceedings - Symposium on Rock Mechanics AU - Lu, Wenbo AU - Hustrulid, William A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 387 EP - 392 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - Yangtze Three Gorges KW - Far East KW - blasting KW - slopes KW - damage KW - optimization KW - Asia KW - excavations KW - China KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52121705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Optimization+of+the+contour+blasting+during+rock+slope+excavation+at+the+Three+Gorges+Project&rft.au=Lu%2C+Wenbo%3BHustrulid%2C+William+A&rft.aulast=Lu&rft.aufirst=Wenbo&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=387&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; blasting; China; damage; excavations; Far East; optimization; rock mechanics; slopes; Yangtze Three Gorges ER - TY - JOUR T1 - Numerical simulation of initiation of tensile and shear cracks AN - 52120856; 2002-019474 JF - Proceedings - Symposium on Rock Mechanics AU - Bobet, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 731 EP - 738 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - laboratory studies KW - fractures KW - experimental studies KW - cracks KW - brittle materials KW - shear KW - tensile strength KW - simulation KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Numerical+simulation+of+initiation+of+tensile+and+shear+cracks&rft.au=Bobet%2C+A&rft.aulast=Bobet&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=731&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - brittle materials; cracks; experimental studies; fractures; laboratory studies; rock mechanics; shear; simulation; tensile strength ER - TY - JOUR T1 - Estimation of REV size and three dimensional hydraulic conductivity tensor for a rock mass through discrete fracture fluid flow modeling AN - 52120831; 2002-019472 JF - Proceedings - Symposium on Rock Mechanics AU - Wang, M AU - Kulatilake, P H S W AU - Um, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 713 EP - 720 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - three-dimensional models KW - igneous rocks KW - granites KW - porous materials KW - fluid dynamics KW - rock mechanics KW - ground water KW - models KW - fractures KW - plutonic rocks KW - boreholes KW - stochastic processes KW - hydraulic conductivity KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Estimation+of+REV+size+and+three+dimensional+hydraulic+conductivity+tensor+for+a+rock+mass+through+discrete+fracture+fluid+flow+modeling&rft.au=Wang%2C+M%3BKulatilake%2C+P+H+S+W%3BUm%2C+J&rft.aulast=Wang&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=713&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; fluid dynamics; fractures; granites; ground water; hydraulic conductivity; igneous rocks; models; plutonic rocks; porous materials; rock mechanics; stochastic processes; three-dimensional models ER - TY - JOUR T1 - Stress-dependent permeability variation and mine subsidence AN - 52120807; 2002-019468 JF - Proceedings - Symposium on Rock Mechanics AU - Zhang, Jincai AU - Roegiers, J C AU - Bai, Mao AU - Zhang, Yuzhuo A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 685 EP - 690 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining KW - mines KW - geologic hazards KW - stress KW - prediction KW - land subsidence KW - variations KW - rock mechanics KW - fractures KW - safety KW - mining geology KW - permeability KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Stress-dependent+permeability+variation+and+mine+subsidence&rft.au=Zhang%2C+Jincai%3BRoegiers%2C+J+C%3BBai%2C+Mao%3BZhang%2C+Yuzhuo&rft.aulast=Zhang&rft.aufirst=Jincai&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=685&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; fractures; geologic hazards; land subsidence; mines; mining; mining geology; permeability; prediction; rock mechanics; safety; stress; variations ER - TY - JOUR T1 - Response of emplacement drifts to seismic hazards at Yucca Mountain AN - 52120760; 2002-019449 JF - Proceedings - Symposium on Rock Mechanics AU - Duan, F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 533 EP - 541 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - Nye County Nevada KW - emplacement KW - rock mechanics KW - radioactive waste KW - safety KW - emplacement drift KW - seismic risk KW - underground installations KW - waste disposal KW - Yucca Mountain KW - earthquakes KW - underground disposal KW - Nevada KW - faults KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Response+of+emplacement+drifts+to+seismic+hazards+at+Yucca+Mountain&rft.au=Duan%2C+F&rft.aulast=Duan&rft.aufirst=F&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=533&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - earthquakes; emplacement; emplacement drift; faults; Nevada; Nye County Nevada; radioactive waste; rock mechanics; safety; seismic risk; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Failure modeling around underground excavations in rocksalt AN - 52120724; 2002-019442 JF - Proceedings - Symposium on Rock Mechanics AU - Salari, M R AU - Saeb, S AU - Patchet, S J AU - Carrasco, R C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 483 EP - 487 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - failures KW - chemically precipitated rocks KW - excavations KW - evaporites KW - rock mechanics KW - models KW - sedimentary rocks KW - creep KW - underground installations KW - waste disposal KW - plasticity KW - underground disposal KW - salt KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Failure+modeling+around+underground+excavations+in+rocksalt&rft.au=Salari%2C+M+R%3BSaeb%2C+S%3BPatchet%2C+S+J%3BCarrasco%2C+R+C&rft.aulast=Salari&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=483&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - chemically precipitated rocks; creep; evaporites; excavations; failures; models; plasticity; rock mechanics; salt; sedimentary rocks; underground disposal; underground installations; waste disposal ER - TY - JOUR T1 - Faulting and seismicity associated with fluid extraction AN - 52120487; 2002-019494 JF - Proceedings - Symposium on Rock Mechanics AU - Chanpura, Rajesh A AU - Germanovich, Leonid N A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 885 EP - 894 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - drawdown KW - boreholes KW - seismicity KW - stress KW - reservoir properties KW - unconformities KW - faults KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Faulting+and+seismicity+associated+with+fluid+extraction&rft.au=Chanpura%2C+Rajesh+A%3BGermanovich%2C+Leonid+N&rft.aulast=Chanpura&rft.aufirst=Rajesh&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=885&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 47 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; drawdown; faults; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; seismicity; stress; unconformities ER - TY - JOUR T1 - Inversion of geophysical measurements for fracture geometry AN - 52120452; 2002-019483 JF - Proceedings - Symposium on Rock Mechanics AU - Brown, S R AU - Smith, M L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 799 EP - 805 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - fractures KW - geophysical methods KW - data processing KW - inverse problem KW - rock mechanics KW - geometry KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Inversion+of+geophysical+measurements+for+fracture+geometry&rft.au=Brown%2C+S+R%3BSmith%2C+M+L&rft.aulast=Brown&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=799&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - data processing; fractures; geometry; geophysical methods; inverse problem; models; rock mechanics ER - TY - JOUR T1 - Preliminary design of Taiwan LLRW underground facility in granitic rock AN - 52120407; 2002-019450 JF - Proceedings - Symposium on Rock Mechanics AU - Boutin, R J AU - Schulman, R F AU - Sholley, M G AU - Borquez, G AU - Chen, T C AU - Chen, Y C Y1 - 2001 PY - 2001 DA - 2001 SP - 543 EP - 550 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - Taiwan KW - Far East KW - igneous rocks KW - granites KW - rock mechanics KW - radioactive waste KW - plutonic rocks KW - underground installations KW - waste disposal KW - Asia KW - low-level waste KW - underground disposal KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Preliminary+design+of+Taiwan+LLRW+underground+facility+in+granitic+rock&rft.au=Boutin%2C+R+J%3BSchulman%2C+R+F%3BSholley%2C+M+G%3BBorquez%2C+G%3BChen%2C+T+C%3BChen%2C+Y+C&rft.aulast=Boutin&rft.aufirst=R&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=543&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - 5 tables N1 - Last updated - 2015-04-16 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; design; Far East; granites; igneous rocks; low-level waste; plutonic rocks; radioactive waste; rock mechanics; Taiwan; underground disposal; underground installations; waste disposal ER - TY - JOUR T1 - Effects of mining on the performance of Waste Isolation Pilot Plant AN - 52120361; 2002-019445 JF - Proceedings - Symposium on Rock Mechanics AU - Ghose, Shankar A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 505 EP - 510 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - mining KW - chemically precipitated rocks KW - Eddy County New Mexico KW - stability KW - effects KW - New Mexico KW - evaporites KW - rock mechanics KW - radioactive waste KW - sedimentary rocks KW - mining geology KW - underground installations KW - Waste Isolation Pilot Plant KW - waste disposal KW - underground disposal KW - salt KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Effects+of+mining+on+the+performance+of+Waste+Isolation+Pilot+Plant&rft.au=Ghose%2C+Shankar&rft.aulast=Ghose&rft.aufirst=Shankar&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=505&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 27 N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - chemically precipitated rocks; Eddy County New Mexico; effects; evaporites; mining; mining geology; New Mexico; radioactive waste; rock mechanics; salt; sedimentary rocks; stability; underground disposal; underground installations; United States; waste disposal; Waste Isolation Pilot Plant ER - TY - JOUR T1 - A micromechanical approach to the nonlinear elastic behaviour of rocks AN - 52120345; 2002-019490 JF - Proceedings - Symposium on Rock Mechanics AU - Deude, V AU - Dormieux, L AU - Lemarchand, E AU - Maghous, S AU - Kondo, D A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 851 EP - 857 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - petroleum engineering KW - elasticity KW - cracks KW - joints KW - reservoir properties KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+micromechanical+approach+to+the+nonlinear+elastic+behaviour+of+rocks&rft.au=Deude%2C+V%3BDormieux%2C+L%3BLemarchand%2C+E%3BMaghous%2C+S%3BKondo%2C+D&rft.aulast=Deude&rft.aufirst=V&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=851&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 5 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; elasticity; fractures; joints; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics ER - TY - JOUR T1 - Modeling and analysis of fluid flows through a rock fracture with wall roughness AN - 52120305; 2002-019471 JF - Proceedings - Symposium on Rock Mechanics AU - Yamatomi, J AU - Mogi, G AU - Adachi, T AU - Sugiura, K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 705 EP - 712 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - limestone KW - Far East KW - roughness KW - data processing KW - fluid dynamics KW - rock mechanics KW - models KW - fractures KW - sedimentary rocks KW - carbonate rocks KW - Asia KW - fractals KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modeling+and+analysis+of+fluid+flows+through+a+rock+fracture+with+wall+roughness&rft.au=Yamatomi%2C+J%3BMogi%2C+G%3BAdachi%2C+T%3BSugiura%2C+K&rft.aulast=Yamatomi&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=705&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; carbonate rocks; data processing; Far East; fluid dynamics; fractals; fractures; Japan; limestone; models; rock mechanics; roughness; sedimentary rocks ER - TY - JOUR T1 - Subsurface migration of toxic fumes from surface construction blasting AN - 52120301; 2002-019429 JF - Proceedings - Symposium on Rock Mechanics AU - McCaffrey, Michael A AU - Su, Benjamin Y A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 381 EP - 386 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining KW - migration KW - toxic materials KW - underground mining KW - explosions KW - pollution KW - rock mechanics KW - gases KW - fractures KW - safety KW - blasting KW - mining geology KW - risk assessment KW - compression KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Subsurface+migration+of+toxic+fumes+from+surface+construction+blasting&rft.au=McCaffrey%2C+Michael+A%3BSu%2C+Benjamin+Y&rft.aulast=McCaffrey&rft.aufirst=Michael&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=381&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 2 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - blasting; compression; explosions; fractures; gases; migration; mining; mining geology; pollution; risk assessment; rock mechanics; safety; toxic materials; underground mining ER - TY - JOUR T1 - Effect of modern state of stress on flow-controlling fractures; a misleading paradigm in need of revision AN - 52120246; 2002-019469 JF - Proceedings - Symposium on Rock Mechanics AU - Stowell, J F W AU - Laubach, S E AU - Olson, J E A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 691 EP - 697 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - orientation KW - migration KW - fractures KW - petroleum engineering KW - stress KW - structural controls KW - reservoir properties KW - rock mechanics KW - reservoir rocks KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Effect+of+modern+state+of+stress+on+flow-controlling+fractures%3B+a+misleading+paradigm+in+need+of+revision&rft.au=Stowell%2C+J+F+W%3BLaubach%2C+S+E%3BOlson%2C+J+E&rft.aulast=Stowell&rft.aufirst=J+F&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=691&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 23 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - fractures; migration; orientation; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; stress; structural controls ER - TY - JOUR T1 - Pilot-scale thermal tests of drip shield configuration for the Yucca Mountain Project AN - 52120189; 2002-019457 JF - Proceedings - Symposium on Rock Mechanics AU - Howard, Cliff AU - Johnston, Roy AU - Taylor, Ron A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 599 EP - 604 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - Nye County Nevada KW - temperature KW - rock mechanics KW - radioactive waste KW - safety KW - underground installations KW - testing KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - disposal barriers KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Pilot-scale+thermal+tests+of+drip+shield+configuration+for+the+Yucca+Mountain+Project&rft.au=Howard%2C+Cliff%3BJohnston%2C+Roy%3BTaylor%2C+Ron&rft.aulast=Howard&rft.aufirst=Cliff&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=599&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 7 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; disposal barriers; Nevada; Nye County Nevada; radioactive waste; rock mechanics; safety; temperature; testing; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Hydro-mechanical behaviour of a rock fracture AN - 52120185; 2002-019484 JF - Proceedings - Symposium on Rock Mechanics AU - Lee, S D AU - Harrison, J P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 807 EP - 813 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - style KW - pressure KW - joints KW - fluid dynamics KW - anisotropy KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Hydro-mechanical+behaviour+of+a+rock+fracture&rft.au=Lee%2C+S+D%3BHarrison%2C+J+P&rft.aulast=Lee&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=807&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - anisotropy; fluid dynamics; fractures; joints; pressure; rock mechanics; style ER - TY - JOUR T1 - Notch sensitivity analysis for the chevron bend and the single-edge-cracked round-bar-in-bending specimens for determining fracture toughness of rock materials AN - 52120137; 2002-019477 JF - Proceedings - Symposium on Rock Mechanics AU - Baek, H AU - Choi, S B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 753 EP - 758 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - failures KW - experimental studies KW - safety KW - cracks KW - chevron folds KW - strength KW - folds KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Notch+sensitivity+analysis+for+the+chevron+bend+and+the+single-edge-cracked+round-bar-in-bending+specimens+for+determining+fracture+toughness+of+rock+materials&rft.au=Baek%2C+H%3BChoi%2C+S+B&rft.aulast=Baek&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=753&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 17 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - chevron folds; cracks; experimental studies; failures; folds; fractures; rock mechanics; safety; strength ER - TY - JOUR T1 - Thermal/hydraulic/chemical experiments to support YMP engineered barrier system analysis AN - 52120095; 2002-019456 JF - Proceedings - Symposium on Rock Mechanics AU - Lowry, W AU - Chipman, V AU - Kendrick, T AU - Mason, N AU - Walton, Z A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 591 EP - 598 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - experimental studies KW - Nye County Nevada KW - temperature KW - rock mechanics KW - radioactive waste KW - ground water KW - underground installations KW - risk assessment KW - waste disposal KW - Yucca Mountain KW - geochemistry KW - underground disposal KW - Nevada KW - disposal barriers KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Thermal%2Fhydraulic%2Fchemical+experiments+to+support+YMP+engineered+barrier+system+analysis&rft.au=Lowry%2C+W%3BChipman%2C+V%3BKendrick%2C+T%3BMason%2C+N%3BWalton%2C+Z&rft.aulast=Lowry&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=591&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 1 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; disposal barriers; experimental studies; geochemistry; ground water; Nevada; Nye County Nevada; radioactive waste; risk assessment; rock mechanics; temperature; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Characteristics of the disturbed rock zone in salt at the Waste Isolation Pilot Plant AN - 52120059; 2002-019446 JF - Proceedings - Symposium on Rock Mechanics AU - Bryan, C R AU - Hansen, F D AU - Chapin, D M AU - Snider, A C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 511 EP - 516 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - chemically precipitated rocks KW - Eddy County New Mexico KW - stability KW - New Mexico KW - evaporites KW - rock mechanics KW - radioactive waste KW - sedimentary rocks KW - underground installations KW - Waste Isolation Pilot Plant KW - waste disposal KW - underground disposal KW - salt KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Characteristics+of+the+disturbed+rock+zone+in+salt+at+the+Waste+Isolation+Pilot+Plant&rft.au=Bryan%2C+C+R%3BHansen%2C+F+D%3BChapin%2C+D+M%3BSnider%2C+A+C&rft.aulast=Bryan&rft.aufirst=C&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=511&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 19 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - chemically precipitated rocks; Eddy County New Mexico; evaporites; New Mexico; radioactive waste; rock mechanics; salt; sedimentary rocks; stability; underground disposal; underground installations; United States; waste disposal; Waste Isolation Pilot Plant ER - TY - JOUR T1 - Probabilistic assessment of sub-level hangingwall stability at the Stillwater Mine, Nye, Montana AN - 52120019; 2002-019434 JF - Proceedings - Symposium on Rock Mechanics AU - Langston, Radford B AU - Kirsten, Hendrik A D A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 417 EP - 422 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - mining engineering KW - mining KW - failures KW - cut and fill KW - hanging wall KW - statistical analysis KW - stratiform deposits KW - stability KW - Stillwater Mine KW - Nye Montana KW - rock mechanics KW - Montana KW - geometry KW - planar bedding structures KW - mining geology KW - metal ores KW - risk assessment KW - probability KW - Stillwater County Montana KW - sedimentary structures KW - 30:Engineering geology KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52120019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Probabilistic+assessment+of+sub-level+hangingwall+stability+at+the+Stillwater+Mine%2C+Nye%2C+Montana&rft.au=Langston%2C+Radford+B%3BKirsten%2C+Hendrik+A+D&rft.aulast=Langston&rft.aufirst=Radford&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=417&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cut and fill; failures; geometry; hanging wall; metal ores; mining; mining engineering; mining geology; Montana; Nye Montana; planar bedding structures; probability; risk assessment; rock mechanics; sedimentary structures; stability; statistical analysis; Stillwater County Montana; Stillwater Mine; stratiform deposits; United States ER - TY - JOUR T1 - Geostatistical modeling of rock fracture surface and simulation of shear tests AN - 52119993; 2002-019492 JF - Proceedings - Symposium on Rock Mechanics AU - Marache, A AU - Riss, J AU - Gentier, S AU - Chiles, J P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 869 EP - 875 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - fractures KW - statistical analysis KW - joints KW - shear tests KW - simulation KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Geostatistical+modeling+of+rock+fracture+surface+and+simulation+of+shear+tests&rft.au=Marache%2C+A%3BRiss%2C+J%3BGentier%2C+S%3BChiles%2C+J+P&rft.aulast=Marache&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=869&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 9 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - fractures; joints; models; rock mechanics; shear tests; simulation; statistical analysis ER - TY - JOUR T1 - Evanescent compressional-mode guided waves propagating between parallel fractures AN - 52119943; 2002-019488 JF - Proceedings - Symposium on Rock Mechanics AU - Xian, Changjiu AU - Nolte, David D AU - Pyrak-Nolte, Laura J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 837 EP - 842 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - P-waves KW - body waves KW - experimental studies KW - three-dimensional models KW - guided waves KW - elastic waves KW - rock mechanics KW - fractures KW - propagation KW - seismic waves KW - compression KW - anisotropy KW - 30:Engineering geology KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Evanescent+compressional-mode+guided+waves+propagating+between+parallel+fractures&rft.au=Xian%2C+Changjiu%3BNolte%2C+David+D%3BPyrak-Nolte%2C+Laura+J&rft.aulast=Xian&rft.aufirst=Changjiu&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=837&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - anisotropy; body waves; compression; elastic waves; experimental studies; fractures; guided waves; P-waves; propagation; rock mechanics; seismic waves; three-dimensional models ER - TY - JOUR T1 - Fracture of rock from wedge indentation AN - 52119897; 2002-019475 JF - Proceedings - Symposium on Rock Mechanics AU - Labuz, J F AU - Chen, L H AU - Cattaneo, S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 739 EP - 744 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - monitoring KW - wedge indentation KW - tensile strength KW - two-dimensional models KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Fracture+of+rock+from+wedge+indentation&rft.au=Labuz%2C+J+F%3BChen%2C+L+H%3BCattaneo%2C+S&rft.aulast=Labuz&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=739&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - fractures; monitoring; rock mechanics; tensile strength; two-dimensional models; wedge indentation ER - TY - JOUR T1 - Three-dimensional tomographic imaging of geologic structure in exploratory studies facility AN - 52119840; 2002-019455 JF - Proceedings - Symposium on Rock Mechanics AU - Hanna, K AU - Descour, J AU - Conover, D AU - Hoekstra, B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 583 EP - 589 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - tomography KW - imagery KW - three-dimensional models KW - site exploration KW - Nye County Nevada KW - rock mechanics KW - radioactive waste KW - underground installations KW - tectonics KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Three-dimensional+tomographic+imaging+of+geologic+structure+in+exploratory+studies+facility&rft.au=Hanna%2C+K%3BDescour%2C+J%3BConover%2C+D%3BHoekstra%2C+B&rft.aulast=Hanna&rft.aufirst=K&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=583&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - imagery; Nevada; Nye County Nevada; radioactive waste; rock mechanics; site exploration; tectonics; three-dimensional models; tomography; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Prediction of long-term stability of emplacement drifts at Yucca Mountain AN - 52119784; 2002-019453 JF - Proceedings - Symposium on Rock Mechanics AU - Sun, Yiming A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 567 EP - 573 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - stability KW - prediction KW - Nye County Nevada KW - rock mechanics KW - radioactive waste KW - safety KW - emplacement drift KW - underground installations KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Prediction+of+long-term+stability+of+emplacement+drifts+at+Yucca+Mountain&rft.au=Sun%2C+Yiming&rft.aulast=Sun&rft.aufirst=Yiming&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=567&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - emplacement drift; Nevada; Nye County Nevada; prediction; radioactive waste; rock mechanics; safety; stability; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Potential use of digital imaging for rock movement detection AN - 52119697; 2002-019441 JF - Proceedings - Symposium on Rock Mechanics AU - Corthesy, Robert AU - Leite, Maria Helena AU - St-Cyr, Claude A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 473 EP - 480 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - rockfalls KW - mining KW - mines KW - imagery KW - Quebec KW - data processing KW - rock mechanics KW - safety KW - detection KW - Canada KW - mining geology KW - mass movements KW - digital simulation KW - Eastern Canada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Potential+use+of+digital+imaging+for+rock+movement+detection&rft.au=Corthesy%2C+Robert%3BLeite%2C+Maria+Helena%3BSt-Cyr%2C+Claude&rft.aulast=Corthesy&rft.aufirst=Robert&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=473&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 5 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Canada; data processing; detection; digital simulation; Eastern Canada; imagery; mass movements; mines; mining; mining geology; Quebec; rock mechanics; rockfalls; safety ER - TY - JOUR T1 - Mining the remaining portion of the Ross Shaft pillar AN - 52119630; 2002-019431 JF - Proceedings - Symposium on Rock Mechanics AU - Brady, T M AU - Johnson, J C AU - Laurenti, M A AU - Pariseau, W G AU - Stahl, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 395 EP - 399 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - mining engineering KW - mining KW - mines KW - three-dimensional models KW - stress KW - statistical analysis KW - Homestake Mine KW - stability KW - Lawrence County South Dakota KW - Ross Shaft KW - Lead South Dakota KW - rock mechanics KW - finite element analysis KW - safety KW - mining geology KW - South Dakota KW - pillars KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Mining+the+remaining+portion+of+the+Ross+Shaft+pillar&rft.au=Brady%2C+T+M%3BJohnson%2C+J+C%3BLaurenti%2C+M+A%3BPariseau%2C+W+G%3BStahl%2C+M&rft.aulast=Brady&rft.aufirst=T&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=395&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - finite element analysis; Homestake Mine; Lawrence County South Dakota; Lead South Dakota; mines; mining; mining engineering; mining geology; pillars; rock mechanics; Ross Shaft; safety; South Dakota; stability; statistical analysis; stress; three-dimensional models; United States ER - TY - JOUR T1 - Modeling of the shear behavior of rock joints under constant normal confining conditions AN - 52119206; 2002-019482 JF - Proceedings - Symposium on Rock Mechanics AU - Kishida, K AU - Adachi, T AU - Tsuno, K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 791 EP - 798 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - fractures KW - style KW - shear KW - joints KW - simulation KW - confining pressure KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modeling+of+the+shear+behavior+of+rock+joints+under+constant+normal+confining+conditions&rft.au=Kishida%2C+K%3BAdachi%2C+T%3BTsuno%2C+K&rft.aulast=Kishida&rft.aufirst=K&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=791&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - confining pressure; fractures; joints; models; rock mechanics; shear; simulation; style ER - TY - JOUR T1 - Second law of thermodynamics and the failure of rock materials AN - 52119169; 2002-019479 JF - Proceedings - Symposium on Rock Mechanics AU - Van, P AU - Vasarhelyi, B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 767 EP - 773 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - failures KW - thermodynamic properties KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Second+law+of+thermodynamics+and+the+failure+of+rock+materials&rft.au=Van%2C+P%3BVasarhelyi%2C+B&rft.aulast=Van&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=767&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 23 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - failures; fractures; rock mechanics; thermodynamic properties ER - TY - JOUR T1 - Thermal behavior of rock mass around openings for low temperature materials storage AN - 52119130; 2002-019463 JF - Proceedings - Symposium on Rock Mechanics AU - Inada, Y AU - Kinoshita, N A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 645 EP - 651 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - experimental studies KW - Far East KW - underground storage KW - strength KW - thermal properties KW - stress KW - temperature KW - rock mechanics KW - cracks KW - underground installations KW - low temperature KW - Asia KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Thermal+behavior+of+rock+mass+around+openings+for+low+temperature+materials+storage&rft.au=Inada%2C+Y%3BKinoshita%2C+N&rft.aulast=Inada&rft.aufirst=Y&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=645&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; cracks; experimental studies; Far East; Japan; low temperature; rock mechanics; strength; stress; temperature; thermal properties; underground installations; underground storage ER - TY - JOUR T1 - Coupled analysis of a THM field experiment in unsaturated buffer-rock system AN - 52119101; 2002-019460 JF - Proceedings - Symposium on Rock Mechanics AU - Rutqvist, J AU - Noorishad, J AU - Tsang, C F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 623 EP - 630 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mines KW - experimental studies KW - Far East KW - buffers KW - unsaturated zone KW - coupling KW - temperature KW - rock mechanics KW - radioactive waste KW - Kamaishi Mine KW - ground water KW - Iwate Japan KW - underground installations KW - Honshu KW - waste disposal KW - heterogeneity KW - Asia KW - underground disposal KW - Japan KW - field studies KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Coupled+analysis+of+a+THM+field+experiment+in+unsaturated+buffer-rock+system&rft.au=Rutqvist%2C+J%3BNoorishad%2C+J%3BTsang%2C+C+F&rft.aulast=Rutqvist&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=623&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 9 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; buffers; coupling; experimental studies; Far East; field studies; ground water; heterogeneity; Honshu; Iwate Japan; Japan; Kamaishi Mine; mines; radioactive waste; rock mechanics; temperature; underground disposal; underground installations; unsaturated zone; waste disposal ER - TY - JOUR T1 - Assessing the disturbed rock zone (DRZ) at the WIPP (Waste Isolation Pilot Plant) in salt using ultrasonic waves AN - 52119071; 2002-019443 JF - Proceedings - Symposium on Rock Mechanics AU - Holcomb, D J AU - Hardy, R D A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 489 EP - 496 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - rockfalls KW - chemically precipitated rocks KW - geophysical surveys KW - Eddy County New Mexico KW - geophysical methods KW - New Mexico KW - evaporites KW - ultrasonic methods KW - rock mechanics KW - acoustical methods KW - sedimentary rocks KW - safety KW - mass movements KW - underground installations KW - surveys KW - risk assessment KW - Waste Isolation Pilot Plant KW - underground disposal KW - salt KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Assessing+the+disturbed+rock+zone+%28DRZ%29+at+the+WIPP+%28Waste+Isolation+Pilot+Plant%29+in+salt+using+ultrasonic+waves&rft.au=Holcomb%2C+D+J%3BHardy%2C+R+D&rft.aulast=Holcomb&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=489&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical methods; chemically precipitated rocks; Eddy County New Mexico; evaporites; geophysical methods; geophysical surveys; mass movements; New Mexico; risk assessment; rock mechanics; rockfalls; safety; salt; sedimentary rocks; surveys; ultrasonic methods; underground disposal; underground installations; United States; Waste Isolation Pilot Plant ER - TY - JOUR T1 - Characterization of the parameters that govern the peak shear strength of rock joints AN - 52119067; 2002-019485 JF - Proceedings - Symposium on Rock Mechanics AU - Grasselli, G AU - Egger, P AU - Wirth, J AU - Hopkins, D A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 817 EP - 821 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - shear strength KW - stability KW - joints KW - Europe KW - Switzerland KW - rock mechanics KW - fractures KW - style KW - Central Europe KW - dams KW - construction KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Characterization+of+the+parameters+that+govern+the+peak+shear+strength+of+rock+joints&rft.au=Grasselli%2C+G%3BEgger%2C+P%3BWirth%2C+J%3BHopkins%2C+D&rft.aulast=Grasselli&rft.aufirst=G&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=817&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Central Europe; construction; dams; design; Europe; fractures; joints; rock mechanics; shear strength; stability; style; Switzerland ER - TY - JOUR T1 - Emerging technologies and the future of geotechnical instrumentation AN - 52119022; 2002-019437 JF - Proceedings - Symposium on Rock Mechanics AU - Girard, J M AU - McHugh, E L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 445 EP - 450 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mining KW - technology KW - monitoring KW - surface mining KW - rock mechanics KW - case studies KW - safety KW - mining geology KW - open-pit mining KW - slope stability KW - instruments KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Emerging+technologies+and+the+future+of+geotechnical+instrumentation&rft.au=Girard%2C+J+M%3BMcHugh%2C+E+L&rft.aulast=Girard&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=445&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 22 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - case studies; instruments; mining; mining engineering; mining geology; monitoring; open-pit mining; rock mechanics; safety; slope stability; surface mining; technology ER - TY - JOUR T1 - Evaluation of the change in permeability of jointed rock mass due to excavation using micromechanics-based continuum (MBC) model AN - 52119019; 2002-019473 JF - Proceedings - Symposium on Rock Mechanics AU - Kim, H M AU - Kuwabara, M AU - Inoue, J AU - Horii, H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 721 EP - 728 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - joints KW - effects KW - excavations KW - rock mechanics KW - radioactive waste KW - models KW - fractures KW - safety KW - style KW - tunnels KW - underground installations KW - risk assessment KW - waste disposal KW - underground disposal KW - permeability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52119019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Evaluation+of+the+change+in+permeability+of+jointed+rock+mass+due+to+excavation+using+micromechanics-based+continuum+%28MBC%29+model&rft.au=Kim%2C+H+M%3BKuwabara%2C+M%3BInoue%2C+J%3BHorii%2C+H&rft.aulast=Kim&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=721&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 36 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - effects; excavations; fractures; joints; models; permeability; radioactive waste; risk assessment; rock mechanics; safety; style; tunnels; underground disposal; underground installations; waste disposal ER - TY - JOUR T1 - Multiphase discrete fracture modeling in support of improved oil recovery from the North Oregon Basin, Wyoming AN - 52118991; 2002-019465 JF - Proceedings - Symposium on Rock Mechanics AU - Dershowitz, W AU - La Pointe, P AU - Parney, B AU - Cladouhos, T A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 663 EP - 668 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - petroleum engineering KW - Paleozoic KW - enhanced recovery KW - production KW - recovery KW - rock mechanics KW - reservoir rocks KW - models KW - Wyoming KW - fractures KW - Oregon Basin KW - reservoir properties KW - Tensleep Sandstone KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Multiphase+discrete+fracture+modeling+in+support+of+improved+oil+recovery+from+the+North+Oregon+Basin%2C+Wyoming&rft.au=Dershowitz%2C+W%3BLa+Pointe%2C+P%3BParney%2C+B%3BCladouhos%2C+T&rft.aulast=Dershowitz&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=663&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - enhanced recovery; fractures; models; Oregon Basin; Paleozoic; petroleum engineering; production; recovery; reservoir properties; reservoir rocks; rock mechanics; Tensleep Sandstone; United States; Wyoming ER - TY - JOUR T1 - Pilot-scale evaluation of engineered barrier systems for the Yucca Mountain Project AN - 52118943; 2002-019458 JF - Proceedings - Symposium on Rock Mechanics AU - Webb, S W AU - George, J T AU - Finley, R E A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 605 EP - 612 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - experimental studies KW - Nye County Nevada KW - rock mechanics KW - radioactive waste KW - safety KW - underground installations KW - testing KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - disposal barriers KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Pilot-scale+evaluation+of+engineered+barrier+systems+for+the+Yucca+Mountain+Project&rft.au=Webb%2C+S+W%3BGeorge%2C+J+T%3BFinley%2C+R+E&rft.aulast=Webb&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=605&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; disposal barriers; experimental studies; Nevada; Nye County Nevada; radioactive waste; rock mechanics; safety; testing; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Distinct element modeling of the drift scale test AN - 52118916; 2002-019448 JF - Proceedings - Symposium on Rock Mechanics AU - Blair, Stephen C AU - Carlson, Steven R AU - Wagoner, Jeffrey L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 527 EP - 531 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - Nye County Nevada KW - rock mechanics KW - radioactive waste KW - models KW - fractures KW - emplacement drift KW - boreholes KW - underground installations KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Distinct+element+modeling+of+the+drift+scale+test&rft.au=Blair%2C+Stephen+C%3BCarlson%2C+Steven+R%3BWagoner%2C+Jeffrey+L&rft.aulast=Blair&rft.aufirst=Stephen&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=527&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 7 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; emplacement drift; fractures; models; Nevada; Nye County Nevada; radioactive waste; rock mechanics; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Application of GIS to the assessment of karst collapse risk in Tangshan, China AN - 52118878; 2002-019438 JF - Proceedings - Symposium on Rock Mechanics AU - Yeung, M R AU - Hu, R L AU - Wang, S J AU - Lee, C F AU - Xiang, J X A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 451 EP - 458 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - failures KW - geographic information systems KW - Far East KW - damage KW - risk assessment KW - karst KW - information systems KW - Tangshan China KW - Asia KW - China KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Application+of+GIS+to+the+assessment+of+karst+collapse+risk+in+Tangshan%2C+China&rft.au=Yeung%2C+M+R%3BHu%2C+R+L%3BWang%2C+S+J%3BLee%2C+C+F%3BXiang%2C+J+X&rft.aulast=Yeung&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=451&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; China; damage; failures; Far East; geographic information systems; information systems; karst; risk assessment; rock mechanics; Tangshan China ER - TY - JOUR T1 - Evaluation of stress influences on ore dilution; a case study AN - 52118840; 2002-019433 JF - Proceedings - Symposium on Rock Mechanics AU - Henning, J G AU - Kaiser, P K AU - Mitri, H S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 409 EP - 415 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - North America KW - mining KW - Temiscamingue County Quebec KW - Quebec KW - stress KW - Superior Province KW - Noranda Quebec KW - cost KW - recovery KW - rock mechanics KW - reservoir rocks KW - Abitibi Belt KW - Canada KW - blasting KW - mining geology KW - Canadian Shield KW - Eastern Canada KW - Rouyn Quebec KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Evaluation+of+stress+influences+on+ore+dilution%3B+a+case+study&rft.au=Henning%2C+J+G%3BKaiser%2C+P+K%3BMitri%2C+H+S&rft.aulast=Henning&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=409&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Abitibi Belt; blasting; Canada; Canadian Shield; cost; Eastern Canada; mining; mining geology; Noranda Quebec; North America; Quebec; recovery; reservoir rocks; rock mechanics; Rouyn Quebec; stress; Superior Province; Temiscamingue County Quebec ER - TY - JOUR T1 - Fracture mapping at exposed rock faces by using close range digital photogrammetry and geodetic total station AN - 52118648; 2002-019487 JF - Proceedings - Symposium on Rock Mechanics AU - Feng, Q AU - Stephansson, O AU - Boberg, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 829 EP - 836 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - style KW - three-dimensional models KW - joints KW - outcrops KW - mapping KW - photogrammetry KW - hydraulic conductivity KW - geodesy KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Fracture+mapping+at+exposed+rock+faces+by+using+close+range+digital+photogrammetry+and+geodetic+total+station&rft.au=Feng%2C+Q%3BStephansson%2C+O%3BBoberg%2C+A&rft.aulast=Feng&rft.aufirst=Q&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=829&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - fractures; geodesy; hydraulic conductivity; joints; mapping; outcrops; photogrammetry; rock mechanics; style; three-dimensional models ER - TY - JOUR T1 - Fracture toughness testing of rock at elevated temperatures and pressures AN - 52118614; 2002-019476 JF - Proceedings - Symposium on Rock Mechanics AU - Seto, M AU - Kuruppu, M D AU - Funatsu, T A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 745 EP - 751 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - experimental studies KW - pressure KW - strength KW - igneous rocks KW - granites KW - sandstone KW - high pressure KW - temperature KW - rock mechanics KW - fractures KW - sedimentary rocks KW - safety KW - plutonic rocks KW - pore pressure KW - clastic rocks KW - high temperature KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Fracture+toughness+testing+of+rock+at+elevated+temperatures+and+pressures&rft.au=Seto%2C+M%3BKuruppu%2C+M+D%3BFunatsu%2C+T&rft.aulast=Seto&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=745&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 26 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - clastic rocks; experimental studies; fractures; granites; high pressure; high temperature; igneous rocks; plutonic rocks; pore pressure; pressure; rock mechanics; safety; sandstone; sedimentary rocks; strength; temperature ER - TY - JOUR T1 - Thermal-hydrologic analysis on design sensitivity of Yucca Mountain nuclear waste repository AN - 52118564; 2002-019452 JF - Proceedings - Symposium on Rock Mechanics AU - Leem, J AU - Dunlap, B E A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 559 EP - 564 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - hydrology KW - Nye County Nevada KW - temperature KW - rock mechanics KW - radioactive waste KW - ground water KW - underground installations KW - risk assessment KW - percolation KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Thermal-hydrologic+analysis+on+design+sensitivity+of+Yucca+Mountain+nuclear+waste+repository&rft.au=Leem%2C+J%3BDunlap%2C+B+E&rft.aulast=Leem&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=559&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; ground water; hydrology; Nevada; Nye County Nevada; percolation; radioactive waste; risk assessment; rock mechanics; temperature; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - Analysis of disposal tunnel for high-level radioactive waste by micromechanics-based continuum model AN - 52118532; 2002-019451 JF - Proceedings - Symposium on Rock Mechanics AU - Yoshida, H AU - Horii, H AU - Kaneko, T A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 551 EP - 558 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - high-level waste KW - Far East KW - rock mechanics KW - radioactive waste KW - models KW - tunnels KW - underground installations KW - waste disposal KW - Asia KW - construction KW - underground disposal KW - permeability KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Analysis+of+disposal+tunnel+for+high-level+radioactive+waste+by+micromechanics-based+continuum+model&rft.au=Yoshida%2C+H%3BHorii%2C+H%3BKaneko%2C+T&rft.aulast=Yoshida&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=551&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; construction; Far East; high-level waste; Japan; models; permeability; radioactive waste; rock mechanics; tunnels; underground disposal; underground installations; waste disposal ER - TY - JOUR T1 - Application of particle flow code to evaluate a concept for detecting hazardous voids in surge piles using profile scanning AN - 52118496; 2002-019439 JF - Proceedings - Symposium on Rock Mechanics AU - Larson, Mark K AU - Iverson, Stephen R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 459 EP - 465 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mining KW - mines KW - safety KW - detection KW - underground cavities KW - mining geology KW - coal mines KW - slope stability KW - rock mechanics KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Application+of+particle+flow+code+to+evaluate+a+concept+for+detecting+hazardous+voids+in+surge+piles+using+profile+scanning&rft.au=Larson%2C+Mark+K%3BIverson%2C+Stephen+R&rft.aulast=Larson&rft.aufirst=Mark&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=459&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - coal mines; detection; mines; mining; mining engineering; mining geology; rock mechanics; safety; slope stability; underground cavities ER - TY - JOUR T1 - Procedures for the design of sillmats with paste backfill AN - 52118436; 2002-019436 JF - Proceedings - Symposium on Rock Mechanics AU - De Souza, E AU - Dirige, A P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 433 EP - 442 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - mining engineering KW - backfill KW - mining KW - mines KW - mining geology KW - sillmats KW - undercut mining KW - design KW - rock mechanics KW - pillars KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52118436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Procedures+for+the+design+of+sillmats+with+paste+backfill&rft.au=De+Souza%2C+E%3BDirige%2C+A+P&rft.aulast=De+Souza&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=433&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - backfill; design; mines; mining; mining engineering; mining geology; models; pillars; rock mechanics; sillmats; undercut mining ER - TY - JOUR T1 - Multivariate clustering analysis of discontinuity data; implementation and applications AN - 52116730; 2002-019491 JF - Proceedings - Symposium on Rock Mechanics AU - Zhou, W AU - Maerz, N H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 861 EP - 868 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - multivariate analysis KW - statistical analysis KW - joints KW - unconformities KW - algorithms KW - rock mechanics KW - cluster analysis KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52116730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Multivariate+clustering+analysis+of+discontinuity+data%3B+implementation+and+applications&rft.au=Zhou%2C+W%3BMaerz%2C+N+H&rft.aulast=Zhou&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=861&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; cluster analysis; fractures; joints; multivariate analysis; rock mechanics; statistical analysis; unconformities ER - TY - JOUR T1 - Hydrological implications of thermally induced geomechanical response at Yucca Mountain, Nevada AN - 52116687; 2002-019459 JF - Proceedings - Symposium on Rock Mechanics AU - Ofoegbu, Goodluck I A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 613 EP - 619 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - hydrology KW - Nye County Nevada KW - temperature KW - rock mechanics KW - radioactive waste KW - ground water KW - safety KW - underground installations KW - heat transfer KW - percolation KW - waste disposal KW - Yucca Mountain KW - underground disposal KW - Nevada KW - design KW - 30:Engineering geology KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52116687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Hydrological+implications+of+thermally+induced+geomechanical+response+at+Yucca+Mountain%2C+Nevada&rft.au=Ofoegbu%2C+Goodluck+I&rft.aulast=Ofoegbu&rft.aufirst=Goodluck&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=613&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 9 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; ground water; heat transfer; hydrology; Nevada; Nye County Nevada; percolation; radioactive waste; rock mechanics; safety; temperature; underground disposal; underground installations; United States; waste disposal; Yucca Mountain ER - TY - JOUR T1 - A review of rock-related fatality trends in the South African gold mining industry AN - 52116649; 2002-019440 JF - Proceedings - Symposium on Rock Mechanics AU - Jaku, E P AU - Jager, A J AU - Roberts, M K C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 467 EP - 471 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - rockfalls KW - mining KW - geologic hazards KW - medical geology KW - rock mechanics KW - safety KW - rock bursts KW - mining geology KW - Southern Africa KW - mass movements KW - metal ores KW - fatalities KW - gold ores KW - Africa KW - South Africa KW - slope stability KW - Witwatersrand KW - 27A:Economic geology, geology of ore deposits KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52116649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+review+of+rock-related+fatality+trends+in+the+South+African+gold+mining+industry&rft.au=Jaku%2C+E+P%3BJager%2C+A+J%3BRoberts%2C+M+K+C&rft.aulast=Jaku&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=467&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 2 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Africa; fatalities; geologic hazards; gold ores; mass movements; medical geology; metal ores; mining; mining geology; rock bursts; rock mechanics; rockfalls; safety; slope stability; South Africa; Southern Africa; Witwatersrand ER - TY - JOUR T1 - Numerical geomechanical modeling for Stillwater Mine, Nye, Montana AN - 52116628; 2002-019435 JF - Proceedings - Symposium on Rock Mechanics AU - MacLaughlin, M M AU - Langston, Radford B AU - Brady, T M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 423 EP - 432 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - mining engineering KW - mining KW - mines KW - numerical models KW - underground mining KW - Stillwater Mine KW - Nye Montana KW - rock mechanics KW - Montana KW - mining geology KW - Stillwater County Montana KW - design KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52116628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Numerical+geomechanical+modeling+for+Stillwater+Mine%2C+Nye%2C+Montana&rft.au=MacLaughlin%2C+M+M%3BLangston%2C+Radford+B%3BBrady%2C+T+M&rft.aulast=MacLaughlin&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=423&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 25 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; mines; mining; mining engineering; mining geology; Montana; numerical models; Nye Montana; rock mechanics; Stillwater County Montana; Stillwater Mine; underground mining; United States ER - TY - JOUR T1 - A numerical simulation and visualization of shear process of rock masses by using geographic information system AN - 52115848; 2002-019495 JF - Proceedings - Symposium on Rock Mechanics AU - Du, S J AU - Esaki, T AU - Mitani, Y AU - Zhou, G Y AU - Ikusada, K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 895 EP - 900 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - visualization KW - fractures KW - geographic information systems KW - digital simulation KW - stress KW - shear KW - data processing KW - information systems KW - simulation KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+numerical+simulation+and+visualization+of+shear+process+of+rock+masses+by+using+geographic+information+system&rft.au=Du%2C+S+J%3BEsaki%2C+T%3BMitani%2C+Y%3BZhou%2C+G+Y%3BIkusada%2C+K&rft.aulast=Du&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=895&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - data processing; digital simulation; fractures; geographic information systems; information systems; rock mechanics; shear; simulation; stress; visualization ER - TY - JOUR T1 - Image processing for automatic extraction of rock joint orientation data from digital images AN - 52115826; 2002-019493 JF - Proceedings - Symposium on Rock Mechanics AU - Post, R M AU - Kemeny, J M AU - Murphy, R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 877 EP - 884 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - orientation KW - fractures KW - digital simulation KW - data processing KW - joints KW - image analysis KW - rock mechanics KW - geometry KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Image+processing+for+automatic+extraction+of+rock+joint+orientation+data+from+digital+images&rft.au=Post%2C+R+M%3BKemeny%2C+J+M%3BMurphy%2C+R&rft.aulast=Post&rft.aufirst=R&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=877&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - data processing; digital simulation; fractures; geometry; image analysis; joints; orientation; rock mechanics ER - TY - JOUR T1 - A comparative analysis of transport through fracture networks AN - 52115780; 2002-019470 JF - Proceedings - Symposium on Rock Mechanics AU - Bai, M AU - McLennan, J AU - Roegiers, J C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 699 EP - 704 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - solute transport KW - fractures KW - heterogeneity KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+comparative+analysis+of+transport+through+fracture+networks&rft.au=Bai%2C+M%3BMcLennan%2C+J%3BRoegiers%2C+J+C&rft.aulast=Bai&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=699&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - fractures; heterogeneity; rock mechanics; solute transport ER - TY - JOUR T1 - Design and application of a biaxial, servo-controlled, test frame to determine the coupled H-M-T properties of discrete fractures AN - 52115746; 2002-019466 JF - Proceedings - Symposium on Rock Mechanics AU - Gale, John E AU - LeMessurier, P AU - Seok, Eunjeong A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 669 EP - 676 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - soil mechanics KW - fractures KW - loading KW - fluid dynamics KW - permeability KW - design KW - temperature KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Design+and+application+of+a+biaxial%2C+servo-controlled%2C+test+frame+to+determine+the+coupled+H-M-T+properties+of+discrete+fractures&rft.au=Gale%2C+John+E%3BLeMessurier%2C+P%3BSeok%2C+Eunjeong&rft.aulast=Gale&rft.aufirst=John&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=669&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 39 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; fluid dynamics; fractures; loading; permeability; rock mechanics; soil mechanics; temperature ER - TY - JOUR T1 - Numerical simulations of mechanical and hydraulic behaviors of rock joint considering the first and second order asperity degradations AN - 52115709; 2002-019486 JF - Proceedings - Symposium on Rock Mechanics AU - Lee, H S AU - Lee, Y K AU - Cho, T F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 823 EP - 827 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - fractures KW - numerical models KW - asperities KW - joints KW - hydraulic conductivity KW - simulation KW - permeability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Numerical+simulations+of+mechanical+and+hydraulic+behaviors+of+rock+joint+considering+the+first+and+second+order+asperity+degradations&rft.au=Lee%2C+H+S%3BLee%2C+Y+K%3BCho%2C+T+F&rft.aulast=Lee&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=823&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - asperities; fractures; hydraulic conductivity; joints; numerical models; permeability; rock mechanics; simulation ER - TY - JOUR T1 - Interaction between two adjacent panels at WIPP AN - 52115698; 2002-019447 JF - Proceedings - Symposium on Rock Mechanics AU - Patchet, S J AU - Carrasco, R C AU - Francke, C T AU - Salari, R AU - Saeb, S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 517 EP - 523 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - chemically precipitated rocks KW - Eddy County New Mexico KW - New Mexico KW - evaporites KW - rock mechanics KW - radioactive waste KW - geometry KW - sedimentary rocks KW - underground installations KW - Waste Isolation Pilot Plant KW - waste disposal KW - underground disposal KW - salt KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Interaction+between+two+adjacent+panels+at+WIPP&rft.au=Patchet%2C+S+J%3BCarrasco%2C+R+C%3BFrancke%2C+C+T%3BSalari%2C+R%3BSaeb%2C+S&rft.aulast=Patchet&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=517&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - chemically precipitated rocks; Eddy County New Mexico; evaporites; geometry; New Mexico; radioactive waste; rock mechanics; salt; sedimentary rocks; underground disposal; underground installations; United States; waste disposal; Waste Isolation Pilot Plant ER - TY - JOUR T1 - Preliminary characterization of fracturing at the site of the Chalk River Laboratories AN - 52115675; 2002-019481 JF - Proceedings - Symposium on Rock Mechanics AU - Piggott, A AU - Moltyaner, G AU - Yamazaki, L AU - Novakowski, K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 785 EP - 790 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - Chalk River Laboratories KW - three-dimensional models KW - rock mechanics KW - radioactive waste KW - Ontario KW - fractures KW - Canada KW - Ottawa Ontario KW - underground installations KW - waste disposal KW - Eastern Canada KW - underground disposal KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Preliminary+characterization+of+fracturing+at+the+site+of+the+Chalk+River+Laboratories&rft.au=Piggott%2C+A%3BMoltyaner%2C+G%3BYamazaki%2C+L%3BNovakowski%2C+K&rft.aulast=Piggott&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=785&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Canada; Chalk River Laboratories; Eastern Canada; fractures; Ontario; Ottawa Ontario; radioactive waste; rock mechanics; three-dimensional models; underground disposal; underground installations; waste disposal ER - TY - JOUR T1 - Determination of mode I fracture toughness of rocks at low temperature AN - 52115633; 2002-019478 JF - Proceedings - Symposium on Rock Mechanics AU - Jung, Y B AU - Lee, H K AU - Synn, J H AU - Park, C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 759 EP - 765 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - experimental studies KW - strength KW - igneous rocks KW - granites KW - sandstone KW - temperature KW - rock mechanics KW - fractures KW - sedimentary rocks KW - plutonic rocks KW - low temperature KW - clastic rocks KW - SEM data KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Determination+of+mode+I+fracture+toughness+of+rocks+at+low+temperature&rft.au=Jung%2C+Y+B%3BLee%2C+H+K%3BSynn%2C+J+H%3BPark%2C+C&rft.aulast=Jung&rft.aufirst=Y&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=759&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - clastic rocks; experimental studies; fractures; granites; igneous rocks; low temperature; plutonic rocks; rock mechanics; sandstone; sedimentary rocks; SEM data; strength; temperature ER - TY - JOUR T1 - A coupled H-M constitutive model to study stability of Lorraine abandoned iron mines AN - 52115561; 2002-019462 JF - Proceedings - Symposium on Rock Mechanics AU - Hoxha, D AU - Grgic, D AU - Homand, F AU - Souley, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 637 EP - 644 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining KW - mines KW - experimental studies KW - Western Europe KW - roof control KW - stability KW - iron ores KW - coupling KW - Europe KW - temperature KW - rock mechanics KW - France KW - laboratory studies KW - mining geology KW - metal ores KW - Lorraine KW - abandoned mines KW - 30:Engineering geology KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+coupled+H-M+constitutive+model+to+study+stability+of+Lorraine+abandoned+iron+mines&rft.au=Hoxha%2C+D%3BGrgic%2C+D%3BHomand%2C+F%3BSouley%2C+M&rft.aulast=Hoxha&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=637&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 7 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - abandoned mines; coupling; Europe; experimental studies; France; iron ores; laboratory studies; Lorraine; metal ores; mines; mining; mining geology; rock mechanics; roof control; stability; temperature; Western Europe ER - TY - JOUR T1 - Three-dimensional analysis of nuclear waste disposal in horizontal boreholes AN - 52115512; 2002-019444 JF - Proceedings - Symposium on Rock Mechanics AU - Francke, C T AU - Saeb, S AU - Carrasco, R C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 497 EP - 503 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - three-dimensional models KW - Eddy County New Mexico KW - stability KW - effects KW - New Mexico KW - rock mechanics KW - radioactive waste KW - boreholes KW - underground installations KW - Waste Isolation Pilot Plant KW - waste disposal KW - underground disposal KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Three-dimensional+analysis+of+nuclear+waste+disposal+in+horizontal+boreholes&rft.au=Francke%2C+C+T%3BSaeb%2C+S%3BCarrasco%2C+R+C&rft.aulast=Francke&rft.aufirst=C&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=497&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; Eddy County New Mexico; effects; New Mexico; radioactive waste; rock mechanics; stability; three-dimensional models; underground disposal; underground installations; United States; waste disposal; Waste Isolation Pilot Plant ER - TY - JOUR T1 - Geotechnical characterization and structural mine design at the Murray Mine, northeastern Nevada AN - 52115482; 2002-019432 JF - Proceedings - Symposium on Rock Mechanics AU - Goodrich, R R AU - Hardy, M P AU - Brechtel, Carl E A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 401 EP - 407 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - United States KW - mining engineering KW - mining KW - mines KW - underground mining KW - Elko County Nevada KW - Independence Mountains KW - rock mechanics KW - fractures KW - Murray Mine KW - mining geology KW - construction KW - Nevada KW - faults KW - design KW - 30:Engineering geology KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Geotechnical+characterization+and+structural+mine+design+at+the+Murray+Mine%2C+northeastern+Nevada&rft.au=Goodrich%2C+R+R%3BHardy%2C+M+P%3BBrechtel%2C+Carl+E&rft.aulast=Goodrich&rft.aufirst=R&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=401&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - construction; design; Elko County Nevada; faults; fractures; Independence Mountains; mines; mining; mining engineering; mining geology; Murray Mine; Nevada; rock mechanics; underground mining; United States ER - TY - JOUR T1 - Behavior of rock under cyclic loading; some preliminary study AN - 52115445; 2002-019428 JF - Proceedings - Symposium on Rock Mechanics AU - Biswas, K AU - Jung, S J AU - May, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 375 EP - 380 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining KW - cyclic loading KW - strain KW - blasting KW - mining geology KW - loading KW - stress KW - drilling KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52115445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Behavior+of+rock+under+cyclic+loading%3B+some+preliminary+study&rft.au=Biswas%2C+K%3BJung%2C+S+J%3BMay%2C+J&rft.aulast=Biswas&rft.aufirst=K&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=375&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 2 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - blasting; cyclic loading; drilling; loading; mining; mining geology; rock mechanics; strain; stress ER - TY - JOUR T1 - Shear strength studies on rock-like models containing arrayed open joints AN - 52114873; 2002-019489 JF - Proceedings - Symposium on Rock Mechanics AU - Wong, R H C AU - Leung, W L AU - Wang, S W A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 843 EP - 849 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - models KW - fractures KW - shear strength KW - cracks KW - style KW - joints KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52114873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Shear+strength+studies+on+rock-like+models+containing+arrayed+open+joints&rft.au=Wong%2C+R+H+C%3BLeung%2C+W+L%3BWang%2C+S+W&rft.aulast=Wong&rft.aufirst=R+H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=843&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; fractures; joints; models; rock mechanics; shear strength; style ER - TY - JOUR T1 - The permeability of thermally cracked and artificially jointed Pocheon Granite AN - 52114848; 2002-019467 JF - Proceedings - Symposium on Rock Mechanics AU - Yoon, Y K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 677 EP - 681 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - pressure KW - igneous rocks KW - granites KW - thermal properties KW - Pocheon Granite KW - joints KW - rock mechanics KW - fractures KW - plutonic rocks KW - cracks KW - mineral assemblages KW - permeability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52114848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+permeability+of+thermally+cracked+and+artificially+jointed+Pocheon+Granite&rft.au=Yoon%2C+Y+K&rft.aulast=Yoon&rft.aufirst=Y&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=677&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 22 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; fractures; granites; igneous rocks; joints; mineral assemblages; permeability; plutonic rocks; Pocheon Granite; pressure; rock mechanics; thermal properties ER - TY - JOUR T1 - An experimental setup to investigate fluid flow through single fractures AN - 52114822; 2002-019464 JF - Proceedings - Symposium on Rock Mechanics AU - Kulatilake, P H S W AU - Morgan, R AU - Um, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 655 EP - 662 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - spatial distribution KW - laboratory studies KW - fractures KW - fluid injection KW - experimental studies KW - style KW - joints KW - fluid dynamics KW - permeability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52114822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=An+experimental+setup+to+investigate+fluid+flow+through+single+fractures&rft.au=Kulatilake%2C+P+H+S+W%3BMorgan%2C+R%3BUm%2C+J&rft.aulast=Kulatilake&rft.aufirst=P+H+S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=655&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 23 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - experimental studies; fluid dynamics; fluid injection; fractures; joints; laboratory studies; permeability; rock mechanics; spatial distribution; style ER - TY - JOUR T1 - Parabolic crack-tip element of two-dimensional displacement discontinuity methods with complete analytical integrations realized by algebraic manipulation AN - 51938065; 2003-071494 JF - Proceedings - Symposium on Rock Mechanics AU - Li, H AU - Mizuta, Y AU - Kyoizumi, N A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1491 EP - 1494 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractured materials KW - fractures KW - cracks KW - heterogeneous materials KW - engineering properties KW - mathematical methods KW - equations KW - two-dimensional models KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51938065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Parabolic+crack-tip+element+of+two-dimensional+displacement+discontinuity+methods+with+complete+analytical+integrations+realized+by+algebraic+manipulation&rft.au=Li%2C+H%3BMizuta%2C+Y%3BKyoizumi%2C+N&rft.aulast=Li&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1491&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; engineering properties; equations; fractured materials; fractures; heterogeneous materials; mathematical methods; rock mechanics; two-dimensional models ER - TY - JOUR T1 - The evaluation of failure components using the seismic moment tensor inversion AN - 51937786; 2003-071473 JF - Proceedings - Symposium on Rock Mechanics AU - Trifu, Cezar I A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1335 EP - 1341 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - mining KW - mines KW - failures KW - engineering properties KW - seismic moment KW - Cochrane District Ontario KW - stress KW - stability KW - rock mechanics KW - Ontario KW - Canada KW - seismicity KW - mining geology KW - ground motion KW - Kidd Creek Mine KW - Eastern Canada KW - earthquakes KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+evaluation+of+failure+components+using+the+seismic+moment+tensor+inversion&rft.au=Trifu%2C+Cezar+I&rft.aulast=Trifu&rft.aufirst=Cezar&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1335&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 9 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Canada; Cochrane District Ontario; earthquakes; Eastern Canada; engineering properties; failures; ground motion; Kidd Creek Mine; mines; mining; mining geology; Ontario; pillars; rock mechanics; seismic moment; seismicity; stability; stress ER - TY - JOUR T1 - Scale effects in the numerical simulation of time-dependent mine seismic activity AN - 51937751; 2003-071468 JF - Proceedings - Symposium on Rock Mechanics AU - Napier, J A L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1297 EP - 1304 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - mining KW - technology KW - numerical models KW - seismicity KW - time factor KW - mining geology KW - stability KW - algorithms KW - simulation KW - excavations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Scale+effects+in+the+numerical+simulation+of+time-dependent+mine+seismic+activity&rft.au=Napier%2C+J+A+L&rft.aulast=Napier&rft.aufirst=J+A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1297&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; excavations; mining; mining geology; numerical models; rock mechanics; seismicity; simulation; stability; technology; time factor ER - TY - JOUR T1 - Information system for large projects in rock engineering AN - 51937728; 2003-071458 JF - Proceedings - Symposium on Rock Mechanics AU - Yufin, S A AU - Postolskaya, O K AU - Man'ko, A V A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1231 EP - 1236 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - geographic information systems KW - engineering properties KW - underground installations KW - information systems KW - waste disposal KW - design KW - rock mechanics KW - radioactive waste KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Information+system+for+large+projects+in+rock+engineering&rft.au=Yufin%2C+S+A%3BPostolskaya%2C+O+K%3BMan%27ko%2C+A+V&rft.aulast=Yufin&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1231&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; engineering properties; geographic information systems; information systems; radioactive waste; rock mechanics; technology; underground installations; waste disposal ER - TY - JOUR T1 - Mechanical, acoustic, and failure properties of shales AN - 51937708; 2003-071451 JF - Proceedings - Symposium on Rock Mechanics AU - Mese, Ali AU - Tutuncu, Azra A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1179 EP - 1183 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - clay KW - failures KW - acoustical properties KW - clastic sediments KW - shale KW - loading KW - stress KW - geophysical methods KW - seismic methods KW - rock mechanics KW - sedimentary rocks KW - sediments KW - propagation KW - clastic rocks KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Mechanical%2C+acoustic%2C+and+failure+properties+of+shales&rft.au=Mese%2C+Ali%3BTutuncu%2C+Azra&rft.aulast=Mese&rft.aufirst=Ali&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1179&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 18 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical properties; clastic rocks; clastic sediments; clay; failures; geophysical methods; loading; propagation; rock mechanics; sedimentary rocks; sediments; seismic methods; shale; stress ER - TY - JOUR T1 - Determination of hydraulic conductivity and storage coefficient through simultaneous measurement of fluid pressure and strains AN - 51937700; 2003-071464 JF - Proceedings - Symposium on Rock Mechanics AU - Tokunaga, T AU - Aoyagi, R AU - Mogi, K AU - Miyamoto, H AU - Tosaka, H AU - Kameya, H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1275 EP - 1280 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - elasticity KW - pressure KW - strain KW - engineering properties KW - pore pressure KW - poroelasticity KW - hydraulic conductivity KW - algorithms KW - storage KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Determination+of+hydraulic+conductivity+and+storage+coefficient+through+simultaneous+measurement+of+fluid+pressure+and+strains&rft.au=Tokunaga%2C+T%3BAoyagi%2C+R%3BMogi%2C+K%3BMiyamoto%2C+H%3BTosaka%2C+H%3BKameya%2C+H&rft.aulast=Tokunaga&rft.aufirst=T&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1275&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 19 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; elasticity; engineering properties; hydraulic conductivity; pore pressure; poroelasticity; pressure; rock mechanics; storage; strain ER - TY - JOUR T1 - Evaluation, monitoring and design concepts for pre-cast concrete segmental primary support under high hydrostatic pressures AN - 51937678; 2003-071435 JF - Proceedings - Symposium on Rock Mechanics AU - Crouthamel, David AU - Swartz, Samuel AU - Curtis, John AU - Warren, Stuart AU - Shamma, John A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1063 EP - 1071 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - monitoring KW - pressure KW - excavations KW - concrete KW - rock mechanics KW - Arrowhead East Tunnel KW - California KW - Southern California KW - tunnels KW - buildings KW - San Bernardino Mountains KW - construction KW - design KW - construction materials KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Evaluation%2C+monitoring+and+design+concepts+for+pre-cast+concrete+segmental+primary+support+under+high+hydrostatic+pressures&rft.au=Crouthamel%2C+David%3BSwartz%2C+Samuel%3BCurtis%2C+John%3BWarren%2C+Stuart%3BShamma%2C+John&rft.aulast=Crouthamel&rft.aufirst=David&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1063&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Arrowhead East Tunnel; buildings; California; concrete; construction; construction materials; design; excavations; monitoring; pressure; rock mechanics; San Bernardino Mountains; Southern California; tunnels; United States ER - TY - JOUR T1 - On a new approach in micromechanics of soils and rocks AN - 51937677; 2003-071452 JF - Proceedings - Symposium on Rock Mechanics AU - Dobroskok, A A AU - Linkov, A M AU - Myer, L R AU - Roegiers, J C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1185 EP - 1190 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - soil mechanics KW - three-dimensional models KW - engineering properties KW - loading KW - micromechanics KW - slope stability KW - simulation KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=On+a+new+approach+in+micromechanics+of+soils+and+rocks&rft.au=Dobroskok%2C+A+A%3BLinkov%2C+A+M%3BMyer%2C+L+R%3BRoegiers%2C+J+C&rft.aulast=Dobroskok&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1185&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 17 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - engineering properties; loading; micromechanics; rock mechanics; simulation; slope stability; soil mechanics; three-dimensional models ER - TY - JOUR T1 - Characteristics of wave-front and evaluation of plastic behaviors of geomaterials AN - 51937665; 2003-071499 JF - Proceedings - Symposium on Rock Mechanics AU - Han, Sixiong AU - Xiao, Mingkui A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1523 EP - 1528 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - finite difference analysis KW - elastic properties KW - statistical analysis KW - time domain analysis KW - propagation KW - elastic waves KW - equations KW - plasticity KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Characteristics+of+wave-front+and+evaluation+of+plastic+behaviors+of+geomaterials&rft.au=Han%2C+Sixiong%3BXiao%2C+Mingkui&rft.aulast=Han&rft.aufirst=Sixiong&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1523&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - elastic properties; elastic waves; equations; finite difference analysis; plasticity; propagation; rock mechanics; statistical analysis; time domain analysis ER - TY - JOUR T1 - Case-based reasoning for slope stability evaluation AN - 51937654; 2003-071448 JF - Proceedings - Symposium on Rock Mechanics AU - Liu, M AU - Zhu, R AU - Xia, Y AU - Li, X A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1159 EP - 1162 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - engineering properties KW - data processing KW - data bases KW - slope stability KW - kinetics KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Case-based+reasoning+for+slope+stability+evaluation&rft.au=Liu%2C+M%3BZhu%2C+R%3BXia%2C+Y%3BLi%2C+X&rft.aulast=Liu&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1159&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 14 N1 - Document feature - 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - data bases; data processing; engineering properties; kinetics; rock mechanics; slope stability; technology ER - TY - JOUR T1 - Deformations and sinking of the cavern roof for the loads of superficial foundations; case of study AN - 51937629; 2003-071436 JF - Proceedings - Symposium on Rock Mechanics AU - Alvarez, E R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1073 EP - 1075 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - Cuba KW - Greater Antilles KW - roof control KW - loading KW - West Indies KW - Caribbean region KW - deformation KW - rock mechanics KW - Havana Cuba KW - case studies KW - Antilles KW - foundations KW - buildings KW - La Habana Cuba KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Deformations+and+sinking+of+the+cavern+roof+for+the+loads+of+superficial+foundations%3B+case+of+study&rft.au=Alvarez%2C+E+R&rft.aulast=Alvarez&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1073&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 3 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Antilles; buildings; Caribbean region; case studies; Cuba; deformation; foundations; Greater Antilles; Havana Cuba; La Habana Cuba; loading; rock mechanics; roof control; West Indies ER - TY - JOUR T1 - Modelling of elastoplastic damage in unsaturated hard rocks and concrete AN - 51937608; 2003-071496 JF - Proceedings - Symposium on Rock Mechanics AU - Bourgeois, F AU - Burlion, N AU - Shao, J F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1503 EP - 1508 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - failures KW - strength KW - elastic properties KW - stress KW - equations KW - concrete KW - rock mechanics KW - models KW - physical properties KW - saturation KW - elastoplastic materials KW - hardness KW - construction KW - design KW - construction materials KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modelling+of+elastoplastic+damage+in+unsaturated+hard+rocks+and+concrete&rft.au=Bourgeois%2C+F%3BBurlion%2C+N%3BShao%2C+J+F&rft.aulast=Bourgeois&rft.aufirst=F&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1503&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - concrete; construction; construction materials; design; elastic properties; elastoplastic materials; equations; failures; hardness; models; physical properties; rock mechanics; saturation; strength; stress ER - TY - JOUR T1 - Stability analysis of a tunnel supported by shotcrete-rockbolt system in hard bedrock AN - 51937591; 2003-071430 JF - Proceedings - Symposium on Rock Mechanics AU - Hwang, H AU - Jung, H AU - Ra, S AU - Kim, D AU - Baek, H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1029 EP - 1034 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - bedrock KW - physical properties KW - shotcrete KW - engineering properties KW - tunnels KW - hardness KW - slope stability KW - excavations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Stability+analysis+of+a+tunnel+supported+by+shotcrete-rockbolt+system+in+hard+bedrock&rft.au=Hwang%2C+H%3BJung%2C+H%3BRa%2C+S%3BKim%2C+D%3BBaek%2C+H&rft.aulast=Hwang&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1029&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 7 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - bedrock; engineering properties; excavations; hardness; physical properties; rock mechanics; shotcrete; slope stability; tunnels ER - TY - JOUR T1 - Numerical derivation of the equivalent hydro-mechanical properties of fractured rock masses using distinct element method AN - 51937586; 2003-071491 JF - Proceedings - Symposium on Rock Mechanics AU - Min, K B AU - Ivars, D M AU - Jing, L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1469 EP - 1476 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - rock masses KW - fractured materials KW - discrete element analysis KW - experimental studies KW - technology KW - hydraulics KW - numerical models KW - mechanical properties KW - equations KW - rock mechanics KW - fractures KW - sampling KW - mathematical methods KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Numerical+derivation+of+the+equivalent+hydro-mechanical+properties+of+fractured+rock+masses+using+distinct+element+method&rft.au=Min%2C+K+B%3BIvars%2C+D+M%3BJing%2C+L&rft.aulast=Min&rft.aufirst=K&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1469&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 21 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - discrete element analysis; equations; experimental studies; fractured materials; fractures; hydraulics; mathematical methods; mechanical properties; numerical models; rock masses; rock mechanics; sampling; technology ER - TY - JOUR T1 - Design and analysis of foundation modifications for a buttress dam AN - 51937556; 2003-071421 JF - Proceedings - Symposium on Rock Mechanics AU - Scott, G A AU - Kottenstette, J T AU - Steighner, J F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 951 EP - 957 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - engineering properties KW - spillways KW - rock mechanics KW - Pueblo Dam KW - Pueblo Colorado KW - foundations KW - Pueblo County Colorado KW - dams KW - Colorado KW - slope stability KW - construction KW - design KW - Arkansas River KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Design+and+analysis+of+foundation+modifications+for+a+buttress+dam&rft.au=Scott%2C+G+A%3BKottenstette%2C+J+T%3BSteighner%2C+J+F&rft.aulast=Scott&rft.aufirst=G&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=951&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 2 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Arkansas River; Colorado; construction; dams; design; engineering properties; foundations; Pueblo Colorado; Pueblo County Colorado; Pueblo Dam; rock mechanics; slope stability; spillways; United States ER - TY - JOUR T1 - General elasto-plastic theory applied to circular tunnels (Ko not = 1) AN - 51937338; 2003-071443 JF - Proceedings - Symposium on Rock Mechanics AU - Bello-Maldonado, A A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1119 EP - 1126 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - circular tunnels KW - technology KW - engineering properties KW - elastoplastic materials KW - tunnels KW - construction KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=General+elasto-plastic+theory+applied+to+circular+tunnels+%28Ko+not+%3D+1%29&rft.au=Bello-Maldonado%2C+A+A&rft.aulast=Bello-Maldonado&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1119&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 2 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - circular tunnels; construction; design; elastoplastic materials; engineering properties; rock mechanics; technology; tunnels ER - TY - JOUR T1 - Geomechanics of large stone structures; a case history from the Washington National Cathedral AN - 51937308; 2003-071434 JF - Proceedings - Symposium on Rock Mechanics AU - Mark, R AU - Richards, R, Jr AU - Mark, C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1055 EP - 1061 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - District of Columbia KW - engineering properties KW - loading KW - building stone KW - buildings KW - Washington National Cathedral KW - construction KW - design KW - construction materials KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Geomechanics+of+large+stone+structures%3B+a+case+history+from+the+Washington+National+Cathedral&rft.au=Mark%2C+R%3BRichards%2C+R%2C+Jr%3BMark%2C+C&rft.aulast=Mark&rft.aufirst=R&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1055&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - building stone; buildings; construction; construction materials; design; District of Columbia; engineering properties; loading; rock mechanics; United States; Washington National Cathedral ER - TY - JOUR T1 - The influence of well bore fluid pressure on drilling penetration rates and stress dependent strength AN - 51937247; 2003-071416 JF - Proceedings - Symposium on Rock Mechanics AU - Rumzan, I AU - Schmitt, D R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 911 EP - 917 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - finite element analysis KW - drilling muds KW - boreholes KW - three-dimensional models KW - fluid pressure KW - strength KW - pore pressure KW - stress KW - statistical analysis KW - drilling KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+influence+of+well+bore+fluid+pressure+on+drilling+penetration+rates+and+stress+dependent+strength&rft.au=Rumzan%2C+I%3BSchmitt%2C+D+R&rft.aulast=Rumzan&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=911&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 27 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; drilling; drilling muds; finite element analysis; fluid pressure; pore pressure; rock mechanics; statistical analysis; strength; stress; three-dimensional models ER - TY - JOUR T1 - Fracture imaging with converted elastic waves AN - 51937207; 2003-071469 JF - Proceedings - Symposium on Rock Mechanics AU - Nihei, Kurt T AU - Nakagawa, S AU - Myer, L R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1305 EP - 1311 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - P-waves KW - body waves KW - imagery KW - seismic profiles KW - geophysical methods KW - elastic waves KW - seismic methods KW - rock mechanics KW - fractures KW - geophysical profiles KW - seismic waves KW - S-waves KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Fracture+imaging+with+converted+elastic+waves&rft.au=Nihei%2C+Kurt+T%3BNakagawa%2C+S%3BMyer%2C+L+R&rft.aulast=Nihei&rft.aufirst=Kurt&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1305&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 19 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - body waves; elastic waves; fractures; geophysical methods; geophysical profiles; imagery; P-waves; rock mechanics; S-waves; seismic methods; seismic profiles; seismic waves ER - TY - JOUR T1 - Probabilistic prediction of landslides on natural slopes in Korea AN - 51937157; 2003-071447 JF - Proceedings - Symposium on Rock Mechanics AU - Chae, B G AU - Kim, W Y AU - Kim, K S AU - Cho, Y C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1153 EP - 1158 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - Far East KW - statistical analysis KW - prediction KW - Korea KW - rock mechanics KW - landslides KW - mass movements KW - classification KW - probability KW - Asia KW - slope stability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Probabilistic+prediction+of+landslides+on+natural+slopes+in+Korea&rft.au=Chae%2C+B+G%3BKim%2C+W+Y%3BKim%2C+K+S%3BCho%2C+Y+C&rft.aulast=Chae&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1153&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; classification; Far East; Korea; landslides; mass movements; prediction; probability; rock mechanics; slope stability; statistical analysis; technology ER - TY - JOUR T1 - Bonded-particle simulations of the in-situ failure test at Olkiluoto AN - 51937138; 2003-071503 JF - Proceedings - Symposium on Rock Mechanics AU - Potyondy, D AU - Autio, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1553 EP - 1560 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - orientation KW - failures KW - Western Europe KW - in situ KW - underground storage KW - Finland KW - loading KW - igneous rocks KW - Europe KW - simulation KW - Eurajoki Finland KW - Olkiluoto KW - rock mechanics KW - radioactive waste KW - Scandinavia KW - tonalite KW - plutonic rocks KW - diorites KW - Western Finland Province KW - tunnels KW - underground installations KW - waste disposal KW - compression KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Bonded-particle+simulations+of+the+in-situ+failure+test+at+Olkiluoto&rft.au=Potyondy%2C+D%3BAutio%2C+J&rft.aulast=Potyondy&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1553&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - compression; diorites; Eurajoki Finland; Europe; failures; Finland; igneous rocks; in situ; loading; Olkiluoto; orientation; plutonic rocks; radioactive waste; rock mechanics; Scandinavia; simulation; tonalite; tunnels; underground installations; underground storage; waste disposal; Western Europe; Western Finland Province ER - TY - JOUR T1 - A method for modeling variation of in situ stress related to lithology AN - 51937113; 2003-071438 JF - Proceedings - Symposium on Rock Mechanics AU - Whyatt, J K A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1087 EP - 1094 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - mines KW - lithofacies KW - failures KW - controls KW - in situ KW - stress KW - slope stability KW - variations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+method+for+modeling+variation+of+in+situ+stress+related+to+lithology&rft.au=Whyatt%2C+J+K&rft.aulast=Whyatt&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1087&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - controls; failures; in situ; lithofacies; mines; models; rock mechanics; slope stability; stress; variations ER - TY - JOUR T1 - Automatic meshing of underground excavations with emphasis on prismatic tunnels AN - 51937092; 2003-071500 JF - Proceedings - Symposium on Rock Mechanics AU - Zaki, A AU - Curran, J H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1531 EP - 1537 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - finite element analysis KW - three-dimensional models KW - engineering properties KW - tunnels KW - underground installations KW - statistical analysis KW - excavations KW - rock mechanics KW - meshing KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Automatic+meshing+of+underground+excavations+with+emphasis+on+prismatic+tunnels&rft.au=Zaki%2C+A%3BCurran%2C+J+H&rft.aulast=Zaki&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1531&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - engineering properties; excavations; finite element analysis; meshing; rock mechanics; statistical analysis; three-dimensional models; tunnels; underground installations ER - TY - JOUR T1 - A study on failure mechanism of block-flexural toppling by physical modelling testing AN - 51937072; 2003-071426 JF - Proceedings - Symposium on Rock Mechanics AU - Wong, R H C AU - Chiu, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 989 EP - 995 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - failures KW - technology KW - blasting KW - testing KW - effects KW - slope stability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+study+on+failure+mechanism+of+block-flexural+toppling+by+physical+modelling+testing&rft.au=Wong%2C+R+H+C%3BChiu%2C+M&rft.aulast=Wong&rft.aufirst=R+H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=989&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 33 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - blasting; effects; failures; rock mechanics; slope stability; technology; testing ER - TY - JOUR T1 - Proceedings of the 38th U.S. rock mechanics symposium, DC rocks 2001; Rock mechanics in the national interest AN - 51937028; 2003-071414 JF - Proceedings - Symposium on Rock Mechanics A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 903 EP - 1570 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - symposia KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Proceedings+of+the+38th+U.S.+rock+mechanics+symposium%2C+DC+rocks+2001%3B+Rock+mechanics+in+the+national+interest&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=903&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Document feature - illus. N1 - SuppNotes - Individual papers are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - rock mechanics; symposia ER - TY - JOUR T1 - Geomechanical and petrophysical properties of fracture systems in Permocarboniferous "red-beds" AN - 51936746; 2003-071459 JF - Proceedings - Symposium on Rock Mechanics AU - Hecht, Christian A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1237 EP - 1243 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractured materials KW - strain KW - engineering properties KW - Paleozoic KW - Carboniferous KW - mechanical properties KW - Permian KW - rock mechanics KW - fractures KW - physical properties KW - sedimentary rocks KW - metamorphic rocks KW - metasedimentary rocks KW - compression KW - clastic rocks KW - red beds KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51936746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Geomechanical+and+petrophysical+properties+of+fracture+systems+in+Permocarboniferous+%22red-beds%22&rft.au=Hecht%2C+Christian+A&rft.aulast=Hecht&rft.aufirst=Christian&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1237&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Carboniferous; clastic rocks; compression; engineering properties; fractured materials; fractures; mechanical properties; metamorphic rocks; metasedimentary rocks; Paleozoic; Permian; physical properties; red beds; rock mechanics; sedimentary rocks; strain ER - TY - JOUR T1 - 3D critical slope stability analysis based on GIS spatial database and Monte Carlo simulation AN - 51936695; 2003-071445 JF - Proceedings - Symposium on Rock Mechanics AU - Esaki, Tetsuro AU - Xie, Mowen AU - Zhou, Guoyun AU - Mitani, Yasuhiro A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1137 EP - 1143 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - geographic information systems KW - three-dimensional models KW - Monte Carlo analysis KW - statistical analysis KW - data processing KW - data bases KW - information systems KW - slope stability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51936695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=3D+critical+slope+stability+analysis+based+on+GIS+spatial+database+and+Monte+Carlo+simulation&rft.au=Esaki%2C+Tetsuro%3BXie%2C+Mowen%3BZhou%2C+Guoyun%3BMitani%2C+Yasuhiro&rft.aulast=Esaki&rft.aufirst=Tetsuro&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1137&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - data bases; data processing; geographic information systems; information systems; Monte Carlo analysis; rock mechanics; slope stability; statistical analysis; technology; three-dimensional models ER - TY - JOUR T1 - Case studies of cable bolts using instrumented king wires AN - 51936646; 2003-071428 JF - Proceedings - Symposium on Rock Mechanics AU - Martin, Lewis A AU - Pakalnis, R AU - Curtin, Richard P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1013 EP - 1020 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - case studies KW - mining KW - technology KW - engineering properties KW - mining geology KW - effects KW - construction KW - cable bolts KW - instruments KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51936646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Case+studies+of+cable+bolts+using+instrumented+king+wires&rft.au=Martin%2C+Lewis+A%3BPakalnis%2C+R%3BCurtin%2C+Richard+P&rft.aulast=Martin&rft.aufirst=Lewis&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1013&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cable bolts; case studies; construction; design; effects; engineering properties; instruments; mining; mining geology; rock mechanics; technology ER - TY - JOUR T1 - Investigation of slope stability for a section of Phelps Dodge Sierrita Mine AN - 51936612; 2003-071423 JF - Proceedings - Symposium on Rock Mechanics AU - Um, J AU - Morin, B AU - Kulatilake, P H S W A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 967 EP - 974 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - mining KW - mines KW - three-dimensional models KW - surface mining KW - Phelps Dodge Sierrita Mine KW - rock mechanics KW - Sierrita Mountains KW - visualization KW - kinematics KW - discontinuities KW - mining geology KW - Arizona KW - Tucson Arizona KW - open-pit mining KW - slope stability KW - Pima County Arizona KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51936612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Investigation+of+slope+stability+for+a+section+of+Phelps+Dodge+Sierrita+Mine&rft.au=Um%2C+J%3BMorin%2C+B%3BKulatilake%2C+P+H+S+W&rft.aulast=Um&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=967&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Arizona; discontinuities; kinematics; mines; mining; mining geology; open-pit mining; Phelps Dodge Sierrita Mine; Pima County Arizona; rock mechanics; Sierrita Mountains; slope stability; surface mining; three-dimensional models; Tucson Arizona; United States; visualization ER - TY - JOUR T1 - Laser cell for triaxial tests on core samples; a new tool for innovative mechanical testing of rock materials AN - 51935430; 2003-071463 JF - Proceedings - Symposium on Rock Mechanics AU - Marsala, A F AU - Figoni, A AU - Pellegrino, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1267 EP - 1273 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - experimental studies KW - laser methods KW - engineering properties KW - mechanical properties KW - deformation KW - triaxial tests KW - new methods KW - instruments KW - cores KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Laser+cell+for+triaxial+tests+on+core+samples%3B+a+new+tool+for+innovative+mechanical+testing+of+rock+materials&rft.au=Marsala%2C+A+F%3BFigoni%2C+A%3BPellegrino%2C+A&rft.aulast=Marsala&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1267&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cores; deformation; engineering properties; experimental studies; instruments; laser methods; mechanical properties; new methods; rock mechanics; triaxial tests ER - TY - JOUR T1 - Use of rock mass rating (RMR) to estimate rock properties for laterally loaded, rock-socketed transmission line foundations AN - 51935393; 2003-071457 JF - Proceedings - Symposium on Rock Mechanics AU - Rose, A T AU - DiGioia, A M AU - Hirany, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1223 EP - 1230 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - foundations KW - technology KW - engineering properties KW - strength KW - loading KW - prediction KW - lateral heterogeneity KW - deformation KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Use+of+rock+mass+rating+%28RMR%29+to+estimate+rock+properties+for+laterally+loaded%2C+rock-socketed+transmission+line+foundations&rft.au=Rose%2C+A+T%3BDiGioia%2C+A+M%3BHirany%2C+A&rft.aulast=Rose&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1223&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - deformation; engineering properties; foundations; lateral heterogeneity; loading; prediction; rock mechanics; strength; technology ER - TY - JOUR T1 - Evaluating the large scale strength of rock mass with the MSDP (sub u) criterion AN - 51935342; 2003-071455 JF - Proceedings - Symposium on Rock Mechanics AU - Aubertin, M AU - Li, L AU - Simon, R A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1209 EP - 1216 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - failures KW - engineering properties KW - strength KW - classification KW - prediction KW - equations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Evaluating+the+large+scale+strength+of+rock+mass+with+the+MSDP+%28sub+u%29+criterion&rft.au=Aubertin%2C+M%3BLi%2C+L%3BSimon%2C+R&rft.aulast=Aubertin&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1209&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 48 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - classification; engineering properties; equations; failures; prediction; rock mechanics; strength ER - TY - JOUR T1 - Physical and particle flow modeling of jointed rock block behavior under uniaxial loading AN - 51935339; 2003-071497 JF - Proceedings - Symposium on Rock Mechanics AU - Malama, B AU - Kulatilake, P H S W A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1509 EP - 1516 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractured materials KW - experimental studies KW - strength KW - loading KW - joints KW - uniaxial tests KW - rock mechanics KW - laboratory studies KW - fractures KW - style KW - discontinuities KW - load tests KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Physical+and+particle+flow+modeling+of+jointed+rock+block+behavior+under+uniaxial+loading&rft.au=Malama%2C+B%3BKulatilake%2C+P+H+S+W&rft.aulast=Malama&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1509&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 19 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - discontinuities; experimental studies; fractured materials; fractures; joints; laboratory studies; load tests; loading; rock mechanics; strength; style; uniaxial tests ER - TY - JOUR T1 - Failure mechanisms, influence functions for equivalent rock properties AN - 51935294; 2003-071495 JF - Proceedings - Symposium on Rock Mechanics AU - Pariseau, W G A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1497 EP - 1502 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - fractured materials KW - fractures KW - failures KW - physical properties KW - style KW - heterogeneous materials KW - joints KW - equations KW - faults KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Failure+mechanisms%2C+influence+functions+for+equivalent+rock+properties&rft.au=Pariseau%2C+W+G&rft.aulast=Pariseau&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1497&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - equations; failures; faults; fractured materials; fractures; heterogeneous materials; joints; models; physical properties; rock mechanics; style ER - TY - JOUR T1 - Influence of cutter geometry in rock cutting AN - 51935291; 2003-071418 JF - Proceedings - Symposium on Rock Mechanics AU - Dagrain, Fabrice AU - Detournay, Emmanuel AU - Richard, Thomas A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 927 EP - 933 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - experimental studies KW - technology KW - strength KW - drilling KW - instruments KW - rock mechanics KW - geometry KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Influence+of+cutter+geometry+in+rock+cutting&rft.au=Dagrain%2C+Fabrice%3BDetournay%2C+Emmanuel%3BRichard%2C+Thomas&rft.aulast=Dagrain&rft.aufirst=Fabrice&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=927&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - drilling; experimental studies; geometry; instruments; models; rock mechanics; strength; technology ER - TY - JOUR T1 - Stochastic fracture modeling for stability assessment of underground facilities in crystalline rocks AN - 51935266; 2003-071493 JF - Proceedings - Symposium on Rock Mechanics AU - Starzec, P AU - Andersson, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1483 EP - 1490 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractured materials KW - stochastic processes KW - engineering properties KW - tunnels KW - underground installations KW - crystalline rocks KW - stability KW - heterogeneity KW - slope stability KW - excavations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Stochastic+fracture+modeling+for+stability+assessment+of+underground+facilities+in+crystalline+rocks&rft.au=Starzec%2C+P%3BAndersson%2C+J&rft.aulast=Starzec&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1483&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 22 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - crystalline rocks; engineering properties; excavations; fractured materials; heterogeneity; rock mechanics; slope stability; stability; stochastic processes; tunnels; underground installations ER - TY - JOUR T1 - Three dimensional discontinuous deformation analyses AN - 51935228; 2003-071485 JF - Proceedings - Symposium on Rock Mechanics AU - Shi, Gen-hua A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1421 EP - 1428 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractures KW - technology KW - style KW - three-dimensional models KW - strain KW - stress KW - discontinuous deformation analysis KW - joints KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Three+dimensional+discontinuous+deformation+analyses&rft.au=Shi%2C+Gen-hua&rft.aulast=Shi&rft.aufirst=Gen-hua&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1421&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - discontinuous deformation analysis; fractures; joints; rock mechanics; strain; stress; style; technology; three-dimensional models ER - TY - JOUR T1 - Simulation of earthquake effects on underground excavations using discontinuous deformation analysis (DDA) AN - 51935198; 2003-071484 JF - Proceedings - Symposium on Rock Mechanics AU - Hsiung, S M AU - Shi, Gen-hua A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1413 EP - 1420 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - rockfalls KW - joints KW - effects KW - simulation KW - excavations KW - rock mechanics KW - fractures KW - style KW - underground cavities KW - mass movements KW - ground motion KW - discontinuous deformation analysis KW - earthquakes KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Simulation+of+earthquake+effects+on+underground+excavations+using+discontinuous+deformation+analysis+%28DDA%29&rft.au=Hsiung%2C+S+M%3BShi%2C+Gen-hua&rft.aulast=Hsiung&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1413&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; discontinuous deformation analysis; earthquakes; effects; excavations; fractures; ground motion; joints; mass movements; rock mechanics; rockfalls; simulation; style; underground cavities ER - TY - JOUR T1 - Theoretical analysis for transversely isotropic cylinders under the axial point load strength test AN - 51935103; 2003-071466 JF - Proceedings - Symposium on Rock Mechanics AU - Wei, X X AU - Chau, K T A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1285 EP - 1290 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - theoretical studies KW - isotropic materials KW - transverse isotropy KW - engineering properties KW - strength KW - load tests KW - tensile strength KW - algorithms KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Theoretical+analysis+for+transversely+isotropic+cylinders+under+the+axial+point+load+strength+test&rft.au=Wei%2C+X+X%3BChau%2C+K+T&rft.aulast=Wei&rft.aufirst=X&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1285&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 9 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; engineering properties; isotropic materials; load tests; rock mechanics; strength; tensile strength; theoretical studies; transverse isotropy ER - TY - JOUR T1 - Effects of valley topography on principal stress orientations AN - 51935054; 2003-071481 JF - Proceedings - Symposium on Rock Mechanics AU - Savage, W Z AU - Morin, R H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1397 EP - 1400 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - orientation KW - topography KW - elasticity KW - valleys KW - geomorphologic effects KW - borehole breakouts KW - stress KW - algorithms KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Effects+of+valley+topography+on+principal+stress+orientations&rft.au=Savage%2C+W+Z%3BMorin%2C+R+H&rft.aulast=Savage&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1397&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; borehole breakouts; elasticity; geomorphologic effects; orientation; rock mechanics; stress; topography; valleys ER - TY - JOUR T1 - Stress-dependent Biot's constant through dynamic measurements on Ekofisk Chalk AN - 51935035; 2003-071456 JF - Proceedings - Symposium on Rock Mechanics AU - Azeemuddin, M AU - Scott, T E, Jr AU - Zaman, M AU - Roegiers, J C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1217 EP - 1222 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - petroleum exploration KW - petroleum engineering KW - experimental studies KW - in situ KW - stress KW - Ekofisk Field KW - petroleum KW - oil and gas fields KW - rock mechanics KW - reservoir rocks KW - chalk KW - sedimentary rocks KW - Ekofisk Formation KW - reservoir properties KW - algorithms KW - North Sea KW - North Atlantic KW - carbonate rocks KW - Atlantic Ocean KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51935035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Stress-dependent+Biot%27s+constant+through+dynamic+measurements+on+Ekofisk+Chalk&rft.au=Azeemuddin%2C+M%3BScott%2C+T+E%2C+Jr%3BZaman%2C+M%3BRoegiers%2C+J+C&rft.aulast=Azeemuddin&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1217&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; Atlantic Ocean; carbonate rocks; chalk; Ekofisk Field; Ekofisk Formation; experimental studies; in situ; North Atlantic; North Sea; oil and gas fields; petroleum; petroleum engineering; petroleum exploration; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; stress ER - TY - JOUR T1 - Seismic validation of micromechanical models AN - 51934964; 2003-071472 JF - Proceedings - Symposium on Rock Mechanics AU - Hazzard, J F AU - Young, R P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1327 EP - 1333 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractures KW - monitoring KW - cracks KW - engineering properties KW - geophysical methods KW - excavations KW - seismic methods KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Seismic+validation+of+micromechanical+models&rft.au=Hazzard%2C+J+F%3BYoung%2C+R+P&rft.aulast=Hazzard&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1327&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 17 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cracks; engineering properties; excavations; fractures; geophysical methods; monitoring; rock mechanics; seismic methods ER - TY - JOUR T1 - Geochemical characterisation and analysis of a landslide in calcschist AN - 51934929; 2003-071444 JF - Proceedings - Symposium on Rock Mechanics AU - Cravero, M AU - Iabichino, G AU - Gulli, D A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1129 EP - 1136 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - bedrock KW - engineering properties KW - schists KW - rock mechanics KW - landslides KW - calcareous composition KW - mountains KW - metamorphic rocks KW - mass movements KW - mechanics KW - slope stability KW - geochemistry KW - 30:Engineering geology KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Geochemical+characterisation+and+analysis+of+a+landslide+in+calcschist&rft.au=Cravero%2C+M%3BIabichino%2C+G%3BGulli%2C+D&rft.aulast=Cravero&rft.aufirst=M&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1129&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 21 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - bedrock; calcareous composition; engineering properties; geochemistry; landslides; mass movements; mechanics; metamorphic rocks; mountains; rock mechanics; schists; slope stability ER - TY - JOUR T1 - The use of numerical method in the design of large underground tunnel and chamber in rock AN - 51934878; 2003-071437 JF - Proceedings - Symposium on Rock Mechanics AU - Halim, I S AU - Chen, W P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1079 EP - 1086 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - models KW - Narragansett Bay KW - Rhode Island KW - engineering properties KW - tunnels KW - underground installations KW - excavations KW - construction KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+use+of+numerical+method+in+the+design+of+large+underground+tunnel+and+chamber+in+rock&rft.au=Halim%2C+I+S%3BChen%2C+W+P&rft.aulast=Halim&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1079&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - construction; design; engineering properties; excavations; models; Narragansett Bay; Rhode Island; rock mechanics; tunnels; underground installations; United States ER - TY - JOUR T1 - Design and construction of a large-diameter wine cave in weak rock AN - 51934844; 2003-071433 JF - Proceedings - Symposium on Rock Mechanics AU - Holtz, S C AU - Romero, V S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1049 EP - 1053 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - Napa California KW - technology KW - underground storage KW - engineering properties KW - Napa County California KW - weak rocks KW - rock mechanics KW - Napa Valley KW - California KW - underground installations KW - slope stability KW - construction KW - instruments KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Design+and+construction+of+a+large-diameter+wine+cave+in+weak+rock&rft.au=Holtz%2C+S+C%3BRomero%2C+V+S&rft.aulast=Holtz&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1049&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - California; construction; design; engineering properties; instruments; Napa California; Napa County California; Napa Valley; rock mechanics; slope stability; technology; underground installations; underground storage; United States; weak rocks ER - TY - JOUR T1 - Brine exposure effects on a Tertiary North Sea shale AN - 51934320; 2003-071478 JF - Proceedings - Symposium on Rock Mechanics AU - Sonstebo, Eyvind F AU - Holt, Rune M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1375 EP - 1380 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - petroleum engineering KW - pressure KW - shale KW - downhole methods KW - rock mechanics KW - reservoir rocks KW - Cenozoic KW - Tertiary KW - sedimentary rocks KW - brines KW - reservoir properties KW - drilling KW - North Sea KW - North Atlantic KW - clastic rocks KW - Atlantic Ocean KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Brine+exposure+effects+on+a+Tertiary+North+Sea+shale&rft.au=Sonstebo%2C+Eyvind+F%3BHolt%2C+Rune+M&rft.aulast=Sonstebo&rft.aufirst=Eyvind&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1375&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 17 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; brines; Cenozoic; clastic rocks; downhole methods; drilling; North Atlantic; North Sea; petroleum engineering; pressure; reservoir properties; reservoir rocks; rock mechanics; sedimentary rocks; shale; Tertiary ER - TY - JOUR T1 - Physical and analytical simulation of in-situ shear test on steeply dipped rock masses AN - 51934303; 2003-071488 JF - Proceedings - Symposium on Rock Mechanics AU - Mizokami, T AU - Ikusada, K AU - Esaki, Tetsuro AU - Mitani, Y A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1445 EP - 1450 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - foundations KW - dip KW - in situ KW - strength KW - shear KW - testing KW - slope stability KW - simulation KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Physical+and+analytical+simulation+of+in-situ+shear+test+on+steeply+dipped+rock+masses&rft.au=Mizokami%2C+T%3BIkusada%2C+K%3BEsaki%2C+Tetsuro%3BMitani%2C+Y&rft.aulast=Mizokami&rft.aufirst=T&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1445&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; dip; foundations; in situ; rock mechanics; shear; simulation; slope stability; strength; testing ER - TY - JOUR T1 - Use of a discrete particle model to assess feasibility of core based stress determination AN - 51934271; 2003-071476 JF - Proceedings - Symposium on Rock Mechanics AU - Holt, Rune M AU - Pestman, Bart J AU - Kenter, Cor J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1361 EP - 1366 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - three-dimensional models KW - loading KW - stress KW - statistical analysis KW - mathematical models KW - feasibility studies KW - cores KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Use+of+a+discrete+particle+model+to+assess+feasibility+of+core+based+stress+determination&rft.au=Holt%2C+Rune+M%3BPestman%2C+Bart+J%3BKenter%2C+Cor+J&rft.aulast=Holt&rft.aufirst=Rune&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1361&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cores; feasibility studies; loading; mathematical models; rock mechanics; statistical analysis; stress; three-dimensional models ER - TY - JOUR T1 - Time-dependent stability implications for planned two-seam mining at the OCI Wyoming, L. P., Big Island trona mine AN - 51934144; 2003-071501 JF - Proceedings - Symposium on Rock Mechanics AU - Gilbride, Leo J AU - Agapito, J F T AU - Hollberg, Kurt F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1539 EP - 1546 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - mining KW - mines KW - experimental studies KW - engineering properties KW - stress KW - stability KW - Big Island Mine KW - rock mechanics KW - Wyoming KW - mining geology KW - underground installations KW - Sweetwater County Wyoming KW - sodium carbonate KW - carbonates KW - trona KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Time-dependent+stability+implications+for+planned+two-seam+mining+at+the+OCI+Wyoming%2C+L.+P.%2C+Big+Island+trona+mine&rft.au=Gilbride%2C+Leo+J%3BAgapito%2C+J+F+T%3BHollberg%2C+Kurt+F&rft.aulast=Gilbride&rft.aufirst=Leo&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1539&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Big Island Mine; carbonates; engineering properties; experimental studies; mines; mining; mining geology; rock mechanics; sodium carbonate; stability; stress; Sweetwater County Wyoming; trona; underground installations; United States; Wyoming ER - TY - JOUR T1 - Stress state of rocks in the vicinity of tunnel mined in a mountain slope AN - 51934131; 2003-071483 JF - Proceedings - Symposium on Rock Mechanics AU - Hodosevich, G A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1407 EP - 1410 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - Kyrgyzstan KW - engineering properties KW - stress KW - statistical analysis KW - power plants KW - Central Asia KW - two-dimensional models KW - rock mechanics KW - least-squares analysis KW - geometry KW - mountains KW - Commonwealth of Independent States KW - tunnels KW - algorithms KW - Pamirs KW - Asia KW - slope stability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Stress+state+of+rocks+in+the+vicinity+of+tunnel+mined+in+a+mountain+slope&rft.au=Hodosevich%2C+G&rft.aulast=Hodosevich&rft.aufirst=G&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1407&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 7 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; Asia; Central Asia; Commonwealth of Independent States; engineering properties; geometry; Kyrgyzstan; least-squares analysis; mountains; Pamirs; power plants; rock mechanics; slope stability; statistical analysis; stress; tunnels; two-dimensional models ER - TY - JOUR T1 - Modelling of anisotropy in elastoplastic sedimentary rocks AN - 51934102; 2003-071498 JF - Proceedings - Symposium on Rock Mechanics AU - Duveau, G AU - Tiantang, Y AU - Shao, J F A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1517 EP - 1522 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - failures KW - anisotropic materials KW - Western Europe KW - engineering properties KW - shale KW - elastic properties KW - Europe KW - equations KW - rock mechanics KW - models KW - France KW - physical properties KW - sedimentary rocks KW - Tournemire France KW - elastoplastic materials KW - Central Massif KW - clastic rocks KW - anisotropy KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modelling+of+anisotropy+in+elastoplastic+sedimentary+rocks&rft.au=Duveau%2C+G%3BTiantang%2C+Y%3BShao%2C+J+F&rft.aulast=Duveau&rft.aufirst=G&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1517&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 7 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - anisotropic materials; anisotropy; Central Massif; clastic rocks; elastic properties; elastoplastic materials; engineering properties; equations; Europe; failures; France; models; physical properties; rock mechanics; sedimentary rocks; shale; Tournemire France; Western Europe ER - TY - JOUR T1 - Modeling underground structure vulnerability in jointed rock AN - 51934042; 2003-071490 JF - Proceedings - Symposium on Rock Mechanics AU - Swift, Robert P AU - Steedman, David W A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1461 EP - 1468 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractured materials KW - failures KW - technology KW - elasticity KW - engineering properties KW - damage KW - joints KW - deformation KW - rock mechanics KW - models KW - fractures KW - style KW - tunnels KW - underground installations KW - testing KW - plasticity KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modeling+underground+structure+vulnerability+in+jointed+rock&rft.au=Swift%2C+Robert+P%3BSteedman%2C+David+W&rft.aulast=Swift&rft.aufirst=Robert&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1461&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 21 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - damage; deformation; elasticity; engineering properties; failures; fractured materials; fractures; joints; models; plasticity; rock mechanics; style; technology; testing; tunnels; underground installations ER - TY - JOUR T1 - Dynamic response of a fractured excavation to blast and seismic waves AN - 51934027; 2003-071492 JF - Proceedings - Symposium on Rock Mechanics AU - Xu, P C AU - Parra, J O AU - Hackert, C L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1477 EP - 1482 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractured materials KW - underground storage KW - engineering properties KW - strength KW - stress KW - stability KW - elastic waves KW - excavations KW - rock mechanics KW - radioactive waste KW - fractures KW - blasting KW - underground installations KW - seismic waves KW - waste disposal KW - dynamic properties KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Dynamic+response+of+a+fractured+excavation+to+blast+and+seismic+waves&rft.au=Xu%2C+P+C%3BParra%2C+J+O%3BHackert%2C+C+L&rft.aulast=Xu&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1477&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - blasting; dynamic properties; elastic waves; engineering properties; excavations; fractured materials; fractures; radioactive waste; rock mechanics; seismic waves; stability; strength; stress; underground installations; underground storage; waste disposal ER - TY - JOUR T1 - A Galerkin boundary integral method for nonhomogeneous materials with cracks AN - 51933986; 2003-071489 JF - Proceedings - Symposium on Rock Mechanics AU - Wang, J AU - Mogilevskaya, S G AU - Crouch, S L A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1453 EP - 1460 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - fractured materials KW - cracks KW - heterogeneous materials KW - engineering properties KW - Fourier analysis KW - data processing KW - equations KW - algorithms KW - heterogeneity KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+Galerkin+boundary+integral+method+for+nonhomogeneous+materials+with+cracks&rft.au=Wang%2C+J%3BMogilevskaya%2C+S+G%3BCrouch%2C+S+L&rft.aulast=Wang&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1453&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; cracks; data processing; engineering properties; equations; Fourier analysis; fractured materials; heterogeneity; heterogeneous materials; models; rock mechanics ER - TY - JOUR T1 - Rock damage characterisation from microseismic monitoring AN - 51933690; 2003-071470 JF - Proceedings - Symposium on Rock Mechanics AU - Gale, W J AU - Heasley, Keith A AU - Iannacchione, A T AU - Swanson, P L AU - Hatherly, P AU - King, A A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1313 EP - 1320 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - mines KW - physical properties KW - monitoring KW - seismicity KW - engineering properties KW - stress KW - ground motion KW - damage KW - earthquakes KW - concepts KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Rock+damage+characterisation+from+microseismic+monitoring&rft.au=Gale%2C+W+J%3BHeasley%2C+Keith+A%3BIannacchione%2C+A+T%3BSwanson%2C+P+L%3BHatherly%2C+P%3BKing%2C+A&rft.aulast=Gale&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1313&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - concepts; damage; earthquakes; engineering properties; ground motion; mines; monitoring; physical properties; rock mechanics; seismicity; stress ER - TY - JOUR T1 - Shear strength determination by back-analysis of slope failures using maximum likelihood method AN - 51933637; 2003-071449 JF - Proceedings - Symposium on Rock Mechanics AU - Calderon, A R AU - Ozbay, M U A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1163 EP - 1167 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractures KW - failures KW - shear strength KW - style KW - engineering properties KW - strength KW - statistical analysis KW - joints KW - equations KW - slope stability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Shear+strength+determination+by+back-analysis+of+slope+failures+using+maximum+likelihood+method&rft.au=Calderon%2C+A+R%3BOzbay%2C+M+U&rft.aulast=Calderon&rft.aufirst=A&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1163&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - engineering properties; equations; failures; fractures; joints; rock mechanics; shear strength; slope stability; statistical analysis; strength; style ER - TY - JOUR T1 - Application of PDC cutters with combined action modes in drilling hard rock AN - 51933586; 2003-071419 JF - Proceedings - Symposium on Rock Mechanics AU - Li, X B AU - Summers, D A AU - Lok, T S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 935 EP - 940 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - experimental studies KW - technology KW - plutonic rocks KW - igneous rocks KW - granites KW - cutters KW - drilling KW - hardness KW - instruments KW - feasibility studies KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Application+of+PDC+cutters+with+combined+action+modes+in+drilling+hard+rock&rft.au=Li%2C+X+B%3BSummers%2C+D+A%3BLok%2C+T+S&rft.aulast=Li&rft.aufirst=X&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=935&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 5 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cutters; drilling; experimental studies; feasibility studies; granites; hardness; igneous rocks; instruments; plutonic rocks; rock mechanics; technology ER - TY - JOUR T1 - Intelligent parallel computing methods for recognizing rock mechanical models and parameters AN - 51933550; 2003-071504 JF - Proceedings - Symposium on Rock Mechanics AU - Feng, Xia-Ting AU - Li, Shaojun AU - Zhang, Youliang A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1561 EP - 1565 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - physical properties KW - factors KW - soft rocks KW - mathematical methods KW - stress KW - algorithms KW - excavations KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Intelligent+parallel+computing+methods+for+recognizing+rock+mechanical+models+and+parameters&rft.au=Feng%2C+Xia-Ting%3BLi%2C+Shaojun%3BZhang%2C+Youliang&rft.aulast=Feng&rft.aufirst=Xia-Ting&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1561&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; excavations; factors; mathematical methods; models; physical properties; rock mechanics; soft rocks; stress ER - TY - JOUR T1 - A new rock/bit interaction model for rotary drilling process AN - 51933541; 2003-071415 JF - Proceedings - Symposium on Rock Mechanics AU - Sun, Xiaoqing A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 903 EP - 910 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - fractures KW - technology KW - stress KW - mathematical models KW - drilling KW - rotary drilling KW - instruments KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+new+rock%2Fbit+interaction+model+for+rotary+drilling+process&rft.au=Sun%2C+Xiaoqing&rft.aulast=Sun&rft.aufirst=Xiaoqing&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=903&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 9 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - drilling; fractures; instruments; mathematical models; models; rock mechanics; rotary drilling; stress; technology ER - TY - JOUR T1 - Two distinct modes of compressive failure in rocks AN - 51933506; 2003-071462 JF - Proceedings - Symposium on Rock Mechanics AU - Chang, C AU - Haimson, B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1259 EP - 1265 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - failures KW - hornfels KW - strength KW - Long Valley Exploratory Well KW - deformation KW - triaxial tests KW - rock mechanics KW - California KW - metamorphic rocks KW - compression KW - SEM data KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Two+distinct+modes+of+compressive+failure+in+rocks&rft.au=Chang%2C+C%3BHaimson%2C+B&rft.aulast=Chang&rft.aufirst=C&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1259&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - California; compression; deformation; failures; hornfels; Long Valley Exploratory Well; metamorphic rocks; rock mechanics; SEM data; strength; triaxial tests; United States ER - TY - JOUR T1 - Changes of crack characteristics induced by damage process AN - 51933447; 2003-071453 JF - Proceedings - Symposium on Rock Mechanics AU - Jeong, G C AU - Seo, Y S AU - Chae, B G AU - Kim, M I A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1191 EP - 1197 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - plutonic rocks KW - Far East KW - cracks KW - engineering properties KW - igneous rocks KW - granites KW - stress KW - Korea KW - compression KW - Asia KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Changes+of+crack+characteristics+induced+by+damage+process&rft.au=Jeong%2C+G+C%3BSeo%2C+Y+S%3BChae%2C+B+G%3BKim%2C+M+I&rft.aulast=Jeong&rft.aufirst=G&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1191&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; compression; cracks; engineering properties; Far East; granites; igneous rocks; Korea; plutonic rocks; rock mechanics; stress ER - TY - JOUR T1 - Nonlinear, hysteretic rock elasticity; deriving modulus surfaces AN - 51933406; 2003-071450 JF - Proceedings - Symposium on Rock Mechanics AU - McCall, K R AU - Boudjema, M AU - Santos, I B AU - Guyer, R A AU - Boitnott, G N A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1171 EP - 1178 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - processes KW - technology KW - elasticity KW - engineering properties KW - stress KW - elastic constants KW - shear modulus KW - slope stability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Nonlinear%2C+hysteretic+rock+elasticity%3B+deriving+modulus+surfaces&rft.au=McCall%2C+K+R%3BBoudjema%2C+M%3BSantos%2C+I+B%3BGuyer%2C+R+A%3BBoitnott%2C+G+N&rft.aulast=McCall&rft.aufirst=K&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1171&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - elastic constants; elasticity; engineering properties; processes; rock mechanics; shear modulus; slope stability; stress; technology ER - TY - JOUR T1 - Finite element modeling of a tunnel in bedded rock; a case study AN - 51933348; 2003-071439 JF - Proceedings - Symposium on Rock Mechanics AU - Vicenzi, I AU - Mitri, H S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1095 EP - 1100 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - monitoring KW - Alps KW - statistical analysis KW - Europe KW - deformation KW - excavations KW - Switzerland KW - layered materials KW - rock mechanics KW - case studies KW - lithofacies KW - finite element analysis KW - Swiss Alps KW - Central Europe KW - tunnels KW - construction KW - design KW - anisotropy KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Finite+element+modeling+of+a+tunnel+in+bedded+rock%3B+a+case+study&rft.au=Vicenzi%2C+I%3BMitri%2C+H+S&rft.aulast=Vicenzi&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1095&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Alps; anisotropy; case studies; Central Europe; construction; deformation; design; Europe; excavations; finite element analysis; layered materials; lithofacies; monitoring; rock mechanics; statistical analysis; Swiss Alps; Switzerland; tunnels ER - TY - JOUR T1 - Mechanical properties and failure mechanisms for clay shale masses AN - 51933346; 2003-071446 JF - Proceedings - Symposium on Rock Mechanics AU - Hsu, Sung-Chi AU - Nelson, Priscilla P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1145 EP - 1152 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - clay KW - failures KW - strain KW - engineering properties KW - clastic sediments KW - shale KW - stress KW - rock mechanics KW - sedimentary rocks KW - sediments KW - slope stability KW - clastic rocks KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Mechanical+properties+and+failure+mechanisms+for+clay+shale+masses&rft.au=Hsu%2C+Sung-Chi%3BNelson%2C+Priscilla+P&rft.aulast=Hsu&rft.aufirst=Sung-Chi&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1145&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 62 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - clastic rocks; clastic sediments; clay; engineering properties; failures; rock mechanics; sedimentary rocks; sediments; shale; slope stability; strain; stress ER - TY - JOUR T1 - Testing of corrosion protected cable bolts by double pipe axial tests AN - 51933298; 2003-071429 JF - Proceedings - Symposium on Rock Mechanics AU - Satola, I S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1021 EP - 1027 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - corrosion KW - technology KW - loading KW - testing KW - cable bolts KW - instruments KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Testing+of+corrosion+protected+cable+bolts+by+double+pipe+axial+tests&rft.au=Satola%2C+I+S&rft.aulast=Satola&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1021&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cable bolts; corrosion; instruments; loading; rock mechanics; technology; testing ER - TY - JOUR T1 - Dynamic failure of an underground structure; could it be induced by a horizontal disturbance? AN - 51933289; 2003-071441 JF - Proceedings - Symposium on Rock Mechanics AU - Uenishi, K AU - Sakurai, S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1107 EP - 1114 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - Kobe Japan KW - failures KW - monitoring KW - Far East KW - damage KW - effects KW - excavations KW - rock mechanics KW - case studies KW - tunnels KW - underground installations KW - Honshu KW - Bantaki Tunnel KW - Asia KW - slope stability KW - Hyogo Japan KW - earthquakes KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Dynamic+failure+of+an+underground+structure%3B+could+it+be+induced+by+a+horizontal+disturbance%3F&rft.au=Uenishi%2C+K%3BSakurai%2C+S&rft.aulast=Uenishi&rft.aufirst=K&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1107&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; Bantaki Tunnel; case studies; damage; earthquakes; effects; excavations; failures; Far East; Honshu; Hyogo Japan; Japan; Kobe Japan; monitoring; rock mechanics; slope stability; tunnels; underground installations ER - TY - JOUR T1 - Mapping, seepage and stability analysis of a 300-foot high quarry wall used as a dam AN - 51933233; 2003-071420 JF - Proceedings - Symposium on Rock Mechanics AU - Tinucci, J P AU - Ilsley, R C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 943 EP - 950 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - retaining walls KW - Illinois KW - quarries KW - mapping KW - dolostone KW - seepage KW - rock mechanics KW - sedimentary rocks KW - Chicago Illinois KW - Thornton Quarry KW - Thornton Illinois KW - carbonate rocks KW - slope stability KW - construction KW - Cook County Illinois KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Mapping%2C+seepage+and+stability+analysis+of+a+300-foot+high+quarry+wall+used+as+a+dam&rft.au=Tinucci%2C+J+P%3BIlsley%2C+R+C&rft.aulast=Tinucci&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=943&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - carbonate rocks; Chicago Illinois; construction; Cook County Illinois; dolostone; Illinois; mapping; quarries; retaining walls; rock mechanics; sedimentary rocks; seepage; slope stability; Thornton Illinois; Thornton Quarry; United States ER - TY - JOUR T1 - Assessing microcrack damage around a tunnel at the Underground Research Laboratory using ultrasonic velocity tomography AN - 51933193; 2003-071417 JF - Proceedings - Symposium on Rock Mechanics AU - Meglis, I L AU - Chow, T AU - Young, R P A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 919 EP - 925 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - tomography KW - technology KW - geophysical surveys KW - microcracks KW - damage KW - Pinawa Manitoba KW - Manitoba KW - ultrasonic methods KW - Underground Research Laboratory KW - two-dimensional models KW - rock mechanics KW - detection KW - cracks KW - Canada KW - underground cavities KW - tunnels KW - surveys KW - Western Canada KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Assessing+microcrack+damage+around+a+tunnel+at+the+Underground+Research+Laboratory+using+ultrasonic+velocity+tomography&rft.au=Meglis%2C+I+L%3BChow%2C+T%3BYoung%2C+R+P&rft.aulast=Meglis&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=919&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Canada; cracks; damage; detection; geophysical surveys; Manitoba; microcracks; Pinawa Manitoba; rock mechanics; surveys; technology; tomography; tunnels; two-dimensional models; ultrasonic methods; underground cavities; Underground Research Laboratory; Western Canada ER - TY - JOUR T1 - Core-based determination of in-situ stress magnitudes AN - 51933188; 2003-071475 JF - Proceedings - Symposium on Rock Mechanics AU - Pestman, Bart J AU - Kenter, Cor J AU - van Munster, Hans G A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1353 EP - 1360 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - petroleum exploration KW - petroleum engineering KW - in situ KW - seismicity KW - stress KW - reservoir properties KW - petroleum KW - acoustical emissions KW - rock mechanics KW - reservoir rocks KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Core-based+determination+of+in-situ+stress+magnitudes&rft.au=Pestman%2C+Bart+J%3BKenter%2C+Cor+J%3Bvan+Munster%2C+Hans+G&rft.aulast=Pestman&rft.aufirst=Bart&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1353&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical emissions; in situ; petroleum; petroleum engineering; petroleum exploration; reservoir properties; reservoir rocks; rock mechanics; seismicity; stress ER - TY - JOUR T1 - The design of an impactor in large diameter split Hopkinson bar for testing rocks AN - 51933147; 2003-071467 JF - Proceedings - Symposium on Rock Mechanics AU - Liu, D S AU - Zhu, P Y AU - Li, X B AU - Lok, T S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1291 EP - 1294 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - engineering properties KW - brittle materials KW - strength KW - testing KW - Hopkinson bar test KW - instruments KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+design+of+an+impactor+in+large+diameter+split+Hopkinson+bar+for+testing+rocks&rft.au=Liu%2C+D+S%3BZhu%2C+P+Y%3BLi%2C+X+B%3BLok%2C+T+S&rft.aulast=Liu&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1291&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - brittle materials; engineering properties; Hopkinson bar test; instruments; rock mechanics; strength; technology; testing ER - TY - JOUR T1 - The influence of delay time and confining pressure on in-situ stress measurement using AE and DRA AN - 51933091; 2003-071465 JF - Proceedings - Symposium on Rock Mechanics AU - Park, P AU - Park, N AU - Hong, C AU - Jeon, S AU - Kim, Y A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1281 EP - 1284 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - pressure KW - in situ KW - underground storage KW - engineering properties KW - underground installations KW - stress KW - algorithms KW - acoustical emissions KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51933091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+influence+of+delay+time+and+confining+pressure+on+in-situ+stress+measurement+using+AE+and+DRA&rft.au=Park%2C+P%3BPark%2C+N%3BHong%2C+C%3BJeon%2C+S%3BKim%2C+Y&rft.aulast=Park&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1281&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical emissions; algorithms; engineering properties; in situ; pressure; rock mechanics; stress; underground installations; underground storage ER - TY - JOUR T1 - Design of de-stress slot at the Golden Giant Mine AN - 51932694; 2003-071502 JF - Proceedings - Symposium on Rock Mechanics AU - Curran, J H AU - Yacoub, T E AU - Hammah, R E AU - Chew, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1547 EP - 1551 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - mines KW - technology KW - Golden Giant Mine KW - Canada KW - Hemlo Deposit KW - stress KW - Eastern Canada KW - design KW - rock mechanics KW - Ontario KW - boundary element analysis KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Design+of+de-stress+slot+at+the+Golden+Giant+Mine&rft.au=Curran%2C+J+H%3BYacoub%2C+T+E%3BHammah%2C+R+E%3BChew%2C+J&rft.aulast=Curran&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1547&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boundary element analysis; Canada; design; Eastern Canada; Golden Giant Mine; Hemlo Deposit; mines; Ontario; rock mechanics; stress; technology ER - TY - JOUR T1 - Discontinuous deformation analysis (DDA) with n (super th) order polynomial displacement functions AN - 51932612; 2003-071487 JF - Proceedings - Symposium on Rock Mechanics AU - Hsiung, S M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1437 EP - 1444 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - fractures KW - anisotropic materials KW - mathematical methods KW - discontinuous deformation analysis KW - algorithms KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Discontinuous+deformation+analysis+%28DDA%29+with+n+%28super+th%29+order+polynomial+displacement+functions&rft.au=Hsiung%2C+S+M&rft.aulast=Hsiung&rft.aufirst=S&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1437&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; anisotropic materials; discontinuous deformation analysis; fractures; mathematical methods; rock mechanics ER - TY - JOUR T1 - In-situ stress state from inversion of fracturing data from oil wells AN - 51932571; 2003-071477 JF - Proceedings - Symposium on Rock Mechanics AU - Djurhuus, J AU - Aadnoy, B S A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1367 EP - 1374 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - oil wells KW - fractures KW - petroleum engineering KW - boreholes KW - in situ KW - stress KW - reservoir properties KW - equations KW - rock mechanics KW - reservoir rocks KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=In-situ+stress+state+from+inversion+of+fracturing+data+from+oil+wells&rft.au=Djurhuus%2C+J%3BAadnoy%2C+B+S&rft.aulast=Djurhuus&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1367&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 7 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; equations; fractures; in situ; oil wells; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; stress ER - TY - JOUR T1 - Acoustic emission, a potential tool for assessing potash support degeneration resulting from inflow brine AN - 51932491; 2003-071474 JF - Proceedings - Symposium on Rock Mechanics AU - De Souza, E AU - Shende, F AU - Urbancic, T A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1343 EP - 1350 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - mines KW - chemically precipitated rocks KW - technology KW - strength KW - loading KW - stability KW - solution KW - excavations KW - evaporites KW - rock mechanics KW - physical properties KW - sedimentary rocks KW - mining geology KW - brines KW - acoustical emissions KW - potash KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Acoustic+emission%2C+a+potential+tool+for+assessing+potash+support+degeneration+resulting+from+inflow+brine&rft.au=De+Souza%2C+E%3BShende%2C+F%3BUrbancic%2C+T&rft.aulast=De+Souza&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1343&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 9 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical emissions; brines; chemically precipitated rocks; evaporites; excavations; loading; mines; mining geology; physical properties; pillars; potash; rock mechanics; sedimentary rocks; solution; stability; strength; technology ER - TY - JOUR T1 - An experimental study on the electrical potential of geomaterials during deformation and its implications in geomechanics AN - 51932453; 2003-071454 JF - Proceedings - Symposium on Rock Mechanics AU - Aydan, O AU - Minato, T AU - Fukue, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1199 EP - 1206 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - processes KW - experimental studies KW - geophysical methods KW - electrical methods KW - Russian Federation KW - resistivity KW - rock mechanics KW - Kamchatka Russian Federation KW - physical properties KW - Commonwealth of Independent States KW - earthquake prediction KW - ground motion KW - Asia KW - earthquakes KW - 30:Engineering geology KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=An+experimental+study+on+the+electrical+potential+of+geomaterials+during+deformation+and+its+implications+in+geomechanics&rft.au=Aydan%2C+O%3BMinato%2C+T%3BFukue%2C+M&rft.aulast=Aydan&rft.aufirst=O&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1199&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; Commonwealth of Independent States; earthquake prediction; earthquakes; electrical methods; experimental studies; geophysical methods; ground motion; Kamchatka Russian Federation; physical properties; processes; resistivity; rock mechanics; Russian Federation ER - TY - JOUR T1 - Design considerations in a long tunnel AN - 51932420; 2003-071442 JF - Proceedings - Symposium on Rock Mechanics AU - Seifabad, Masoud Cheraghi A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1115 EP - 1117 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - engineering properties KW - tunnels KW - stability KW - slope stability KW - excavations KW - construction KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Design+considerations+in+a+long+tunnel&rft.au=Seifabad%2C+Masoud+Cheraghi&rft.aulast=Seifabad&rft.aufirst=Masoud&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1115&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 6 N1 - Document feature - 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - construction; design; engineering properties; excavations; rock mechanics; slope stability; stability; technology; tunnels ER - TY - JOUR T1 - Real time monitoring of instrumented ground support from the engineer's desk AN - 51932385; 2003-071427 JF - Proceedings - Symposium on Rock Mechanics AU - Bawden, W F AU - Lausch, P AU - Taylor, G C A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1007 EP - 1011 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - monitoring KW - Canada KW - engineering properties KW - time factor KW - cables KW - bolting KW - construction KW - instruments KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Real+time+monitoring+of+instrumented+ground+support+from+the+engineer%27s+desk&rft.au=Bawden%2C+W+F%3BLausch%2C+P%3BTaylor%2C+G+C&rft.aulast=Bawden&rft.aufirst=W&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1007&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 5 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - bolting; cables; Canada; construction; engineering properties; instruments; monitoring; rock mechanics; technology; time factor ER - TY - JOUR T1 - Estimating rock mass boundary conditions for the AECL's Underground Research Laboratory, Canada AN - 51932365; 2003-071480 JF - Proceedings - Symposium on Rock Mechanics AU - Tonon, F AU - Amadei, B A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1389 EP - 1396 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - elasticity KW - in situ KW - three-dimensional models KW - stress KW - Pinawa Manitoba KW - Manitoba KW - Underground Research Laboratory KW - rock mechanics KW - models KW - Canada KW - underground installations KW - Western Canada KW - algorithms KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Estimating+rock+mass+boundary+conditions+for+the+AECL%27s+Underground+Research+Laboratory%2C+Canada&rft.au=Tonon%2C+F%3BAmadei%2C+B&rft.aulast=Tonon&rft.aufirst=F&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1389&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 25 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; Canada; elasticity; in situ; Manitoba; models; Pinawa Manitoba; rock mechanics; stress; three-dimensional models; underground installations; Underground Research Laboratory; Western Canada ER - TY - JOUR T1 - Modeling of great extent rock avalanches using an homogenization approach AN - 51932343; 2003-071424 JF - Proceedings - Symposium on Rock Mechanics AU - Bouzid, I Rochet AU - Viktorovitch, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 975 EP - 982 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - avalanches KW - rockfalls KW - mass movements KW - heterogeneity KW - slope stability KW - feasibility studies KW - two-dimensional models KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Modeling+of+great+extent+rock+avalanches+using+an+homogenization+approach&rft.au=Bouzid%2C+I+Rochet%3BViktorovitch%2C+M&rft.aulast=Bouzid&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=975&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 19 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - avalanches; feasibility studies; heterogeneity; mass movements; rock mechanics; rockfalls; slope stability; two-dimensional models ER - TY - JOUR T1 - Analysis of erosion processes downstream of spillways in large dams AN - 51932315; 2003-071422 JF - Proceedings - Symposium on Rock Mechanics AU - Simoes, Gustavo Ferreira AU - Vargas, Euripedes do Amaral, Jr A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 959 EP - 966 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - processes KW - fractures KW - South America KW - erosion KW - Tucurui Dam KW - Brazil KW - dams KW - spillways KW - construction KW - design KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Analysis+of+erosion+processes+downstream+of+spillways+in+large+dams&rft.au=Simoes%2C+Gustavo+Ferreira%3BVargas%2C+Euripedes+do+Amaral%2C+Jr&rft.aulast=Simoes&rft.aufirst=Gustavo&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=959&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 23 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Brazil; construction; dams; design; erosion; fractures; processes; rock mechanics; South America; spillways; Tucurui Dam ER - TY - JOUR T1 - Accuracy of the DDA method with respect to a single sliding block AN - 51932157; 2003-071486 JF - Proceedings - Symposium on Rock Mechanics AU - Doolin, D M AU - Sitar, N A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1429 EP - 1435 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - models KW - technology KW - engineering properties KW - discontinuous deformation analysis KW - slope stability KW - accuracy KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51932157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Accuracy+of+the+DDA+method+with+respect+to+a+single+sliding+block&rft.au=Doolin%2C+D+M%3BSitar%2C+N&rft.aulast=Doolin&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1429&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - accuracy; discontinuous deformation analysis; engineering properties; models; rock mechanics; slope stability; technology ER - TY - JOUR T1 - Statistical evaluation of six rock failure criteria constrained by polyaxial test data AN - 51931918; 2003-071461 JF - Proceedings - Symposium on Rock Mechanics AU - Colmenares, L B AU - Zoback, M D A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1251 EP - 1258 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - failures KW - physical properties KW - KTB KW - engineering properties KW - brittle materials KW - stress KW - statistical analysis KW - testing KW - algorithms KW - triaxial tests KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51931918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Statistical+evaluation+of+six+rock+failure+criteria+constrained+by+polyaxial+test+data&rft.au=Colmenares%2C+L+B%3BZoback%2C+M+D&rft.aulast=Colmenares&rft.aufirst=L&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1251&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; brittle materials; engineering properties; failures; KTB; physical properties; rock mechanics; statistical analysis; stress; testing; triaxial tests ER - TY - JOUR T1 - The ratio of dynamic and static Young's moduli; measurements in disturbed rock in the laboratory and in situ AN - 51931876; 2003-071460 JF - Proceedings - Symposium on Rock Mechanics AU - Goebel, I R AU - Ranft, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1245 EP - 1248 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - experimental studies KW - technology KW - in situ KW - underground storage KW - elastic properties KW - elastic constants KW - rock mechanics KW - radioactive waste KW - laboratory studies KW - boreholes KW - heterogeneous materials KW - dynamics KW - underground installations KW - waste disposal KW - design KW - Young's modulus KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51931876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=The+ratio+of+dynamic+and+static+Young%27s+moduli%3B+measurements+in+disturbed+rock+in+the+laboratory+and+in+situ&rft.au=Goebel%2C+I+R%3BRanft%2C+M&rft.aulast=Goebel&rft.aufirst=I&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1245&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - boreholes; design; dynamics; elastic constants; elastic properties; experimental studies; heterogeneous materials; in situ; laboratory studies; radioactive waste; rock mechanics; technology; underground installations; underground storage; waste disposal; Young's modulus ER - TY - JOUR T1 - In-situ rockfall tests for evaluation of rockfall protection fences in Korea AN - 51931825; 2003-071425 JF - Proceedings - Symposium on Rock Mechanics AU - Koo, H B AU - Park, H J AU - Park, S W A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 983 EP - 987 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - protection KW - rockfalls KW - Far East KW - in situ KW - mass movements KW - fences KW - Korea KW - Asia KW - slope stability KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51931825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=In-situ+rockfall+tests+for+evaluation+of+rockfall+protection+fences+in+Korea&rft.au=Koo%2C+H+B%3BPark%2C+H+J%3BPark%2C+S+W&rft.aulast=Koo&rft.aufirst=H&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=983&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; Far East; fences; in situ; Korea; mass movements; protection; rock mechanics; rockfalls; slope stability ER - TY - JOUR T1 - Analysis of overcoring rock stress data in the Aspo region AN - 51929905; 2003-071482 JF - Proceedings - Symposium on Rock Mechanics AU - Ask, D AU - Stephansson, O AU - Cornet, F H A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1401 EP - 1405 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - Aspo Hard Rock Laboratory KW - Western Europe KW - in situ KW - underground storage KW - stress KW - Kalmar Sweden KW - Aspo Sweden KW - Europe KW - rock mechanics KW - Scandinavia KW - underground installations KW - waste disposal KW - Sweden KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51929905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Analysis+of+overcoring+rock+stress+data+in+the+Aspo+region&rft.au=Ask%2C+D%3BStephansson%2C+O%3BCornet%2C+F+H&rft.aulast=Ask&rft.aufirst=D&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1401&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 19 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Aspo Hard Rock Laboratory; Aspo Sweden; Europe; in situ; Kalmar Sweden; rock mechanics; Scandinavia; stress; Sweden; underground installations; underground storage; waste disposal; Western Europe ER - TY - JOUR T1 - In-situ rock stress measurements by the acoustic emission method using cored samples of sedimentary rock AN - 51929498; 2003-071479 JF - Proceedings - Symposium on Rock Mechanics AU - Soma, N AU - Seto, M A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1381 EP - 1386 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - sedimentary rocks KW - boreholes KW - in situ KW - sampling KW - stress KW - testing KW - deformation KW - acoustical emissions KW - cores KW - rock mechanics KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51929498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=In-situ+rock+stress+measurements+by+the+acoustic+emission+method+using+cored+samples+of+sedimentary+rock&rft.au=Soma%2C+N%3BSeto%2C+M&rft.aulast=Soma&rft.aufirst=N&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1381&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - acoustical emissions; boreholes; cores; deformation; in situ; rock mechanics; sampling; sedimentary rocks; stress; testing ER - TY - JOUR T1 - Creep along weak planes in roof and how it affects stability AN - 51913354; 2003-086016 AB - Researchers at the National Institute for Occupational Safety and Health (NIOSH) are studying the time-dependent response of rock stressed along weakness planes. The objective is to improve mine safety by reducing the number of roof falls that cause injuries and fatalities to miners. Researchers conducted direct-shear tests on mudstone overcored from a coal mine roof. Results showed frictional strength weakens with displacement along the shearing planes. Results of direct-shear creep tests also showed time-dependent deformation. Test measurements were compared to classical analytical models. Results suggest that the risk of roof collapse may be decreased through layout and support design to reduce creep rates and thus slow progression toward failure. JF - Transactions of Society for Mining, Metallurgy, and Exploration AU - Larson, M K AU - Wade, R G Y1 - 2001 PY - 2001 DA - 2001 SP - 47 EP - 54 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 310 SN - 1075-8623, 1075-8623 KW - mining KW - underground mining KW - roof control KW - stress KW - weak rocks KW - stability KW - friction KW - mathematical models KW - triaxial tests KW - rock mechanics KW - safety KW - mining geology KW - creep KW - shear KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51913354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.atitle=Creep+along+weak+planes+in+roof+and+how+it+affects+stability&rft.au=Larson%2C+M+K%3BWade%2C+R+G&rft.aulast=Larson&rft.aufirst=M&rft.date=2001-01-01&rft.volume=310&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.issn=10758623&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 40 N1 - PubXState - CO N1 - Document feature - illus. incl. 2 tables N1 - SuppNotes - Preprint number 00-130, presented at the SME annual meeting, Feb. 28-March 1, 2000, Salt lake City, Utah. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - creep; friction; mathematical models; mining; mining geology; rock mechanics; roof control; safety; shear; stability; stress; triaxial tests; underground mining; weak rocks ER - TY - JOUR T1 - Silica and respirable dust exposures in the field and lab; a case study AN - 51821416; 2004-054940 JF - Conference on Fossil Resources - Abstracts with Programs AU - Madsen, Scott K AU - Burroughs, G Edward AU - Elder, Ann S AU - Anonymous Y1 - 2001 PY - 2001 DA - 2001 EP - unpaginated PB - USDA Forest Service, Grand Junction, CO VL - 6 KW - silicates KW - preparation KW - silica minerals KW - clastic sediments KW - human ecology KW - sample preparation KW - safety KW - silica KW - dust KW - cristobalite KW - sediments KW - framework silicates KW - fossils KW - 08:General paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51821416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Conference+on+Fossil+Resources+-+Abstracts+with+Programs&rft.atitle=Silica+and+respirable+dust+exposures+in+the+field+and+lab%3B+a+case+study&rft.au=Madsen%2C+Scott+K%3BBurroughs%2C+G+Edward%3BElder%2C+Ann+S%3BAnonymous&rft.aulast=Madsen&rft.aufirst=Scott&rft.date=2001-01-01&rft.volume=6&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Fossil+Resources+-+Abstracts+with+Programs&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - The sixth conference on fossil resources N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - #06029 N1 - SubjectsTermNotLitGenreText - clastic sediments; cristobalite; dust; fossils; framework silicates; human ecology; preparation; safety; sample preparation; sediments; silica; silica minerals; silicates ER - TY - JOUR T1 - Hydraulic fracturing to induce caving; fracture model development and comparison to field data AN - 50305318; 2002-019412 JF - Proceedings - Symposium on Rock Mechanics AU - Jeffrey, Rob G AU - Settari, A AU - Mills, K W AU - Zhang, X AU - Detournay, Emmanuel A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 251 EP - 259 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - hydraulic fracturing KW - mining KW - failures KW - petroleum engineering KW - underground mining KW - stability KW - rock mechanics KW - reservoir rocks KW - models KW - fractures KW - longwall mining KW - reservoir properties KW - algorithms KW - field studies KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50305318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Hydraulic+fracturing+to+induce+caving%3B+fracture+model+development+and+comparison+to+field+data&rft.au=Jeffrey%2C+Rob+G%3BSettari%2C+A%3BMills%2C+K+W%3BZhang%2C+X%3BDetournay%2C+Emmanuel&rft.aulast=Jeffrey&rft.aufirst=Rob&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=251&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; failures; field studies; fractures; hydraulic fracturing; longwall mining; mining; models; petroleum engineering; reservoir properties; reservoir rocks; rock mechanics; stability; underground mining ER - TY - JOUR T1 - Strata control technology by grouting in soft rock roadway AN - 50302827; 2003-071432 JF - Proceedings - Symposium on Rock Mechanics AU - Zhang, Nong AU - Bai, Jianbiao AU - Zhou, Junyao AU - Cheng, Xinming AU - Zhu, Ziliang AU - Chang, Laichuan A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1041 EP - 1045 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - mines KW - technology KW - Far East KW - engineering properties KW - coal mines KW - grouting KW - Lulin China KW - rock mechanics KW - physical properties KW - Asia KW - construction KW - roads KW - instruments KW - design KW - consolidation KW - China KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50302827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Strata+control+technology+by+grouting+in+soft+rock+roadway&rft.au=Zhang%2C+Nong%3BBai%2C+Jianbiao%3BZhou%2C+Junyao%3BCheng%2C+Xinming%3BZhu%2C+Ziliang%3BChang%2C+Laichuan&rft.aulast=Zhang&rft.aufirst=Nong&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1041&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 4 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - Asia; China; coal mines; consolidation; construction; design; engineering properties; Far East; grouting; instruments; Lulin China; mines; physical properties; roads; rock mechanics; technology ER - TY - JOUR T1 - Supervision using the latest information technology in the existing tunnel during close excavation of highway tunnels AN - 50302229; 2003-071440 JF - Proceedings - Symposium on Rock Mechanics AU - Benedik, Rasa AU - Nilsson, Alf A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1101 EP - 1105 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - Western Europe KW - data processing KW - Europe KW - excavations KW - rock mechanics KW - computer programs KW - Scandinavia KW - safety KW - information technology KW - tunnels KW - roads KW - instruments KW - Sweden KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50302229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Supervision+using+the+latest+information+technology+in+the+existing+tunnel+during+close+excavation+of+highway+tunnels&rft.au=Benedik%2C+Rasa%3BNilsson%2C+Alf&rft.aulast=Benedik&rft.aufirst=Rasa&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1101&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - computer programs; data processing; Europe; excavations; information technology; instruments; roads; rock mechanics; safety; Scandinavia; Sweden; technology; tunnels; Western Europe ER - TY - JOUR T1 - A study on mechanical principle of floor heave of roadway driving along next goaf in coal face with fully mechanized top-coal caving AN - 50302147; 2002-019424 JF - Proceedings - Symposium on Rock Mechanics AU - Wang, Weijun AU - Hou, Chaojiong AU - Li, Xuehua A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 351 EP - 354 PB - A.A. Balkema, [location varies] VL - 38, Vol. 1 SN - 0586-3031, 0586-3031 KW - mining engineering KW - mining KW - mines KW - pressure KW - roof control KW - stress KW - coal mines KW - coal seams KW - rock mechanics KW - goaf KW - safety KW - mining geology KW - algorithms KW - roads KW - pillars KW - 30:Engineering geology KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50302147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+study+on+mechanical+principle+of+floor+heave+of+roadway+driving+along+next+goaf+in+coal+face+with+fully+mechanized+top-coal+caving&rft.au=Wang%2C+Weijun%3BHou%2C+Chaojiong%3BLi%2C+Xuehua&rft.aulast=Wang&rft.aufirst=Weijun&rft.date=2001-01-01&rft.volume=38%2C+Vol.+1&rft.issue=&rft.spage=351&rft.isbn=9026518366&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U. S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - algorithms; coal mines; coal seams; goaf; mines; mining; mining engineering; mining geology; pillars; pressure; roads; rock mechanics; roof control; safety; stress ER - TY - JOUR T1 - Three dimensional microseismic monitoring of a Utah longwall AN - 50302109; 2003-071471 JF - Proceedings - Symposium on Rock Mechanics AU - Ellenberger, J L AU - Heasley, Keith A AU - Swanson, P L AU - Mercier, J A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1321 EP - 1326 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - United States KW - mining KW - overburden KW - monitoring KW - geologic hazards KW - underground mining KW - three-dimensional models KW - engineering properties KW - stability KW - rock mechanics KW - foundations KW - safety KW - longwall mining KW - seismicity KW - rock bursts KW - Utah KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50302109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=Three+dimensional+microseismic+monitoring+of+a+Utah+longwall&rft.au=Ellenberger%2C+J+L%3BHeasley%2C+Keith+A%3BSwanson%2C+P+L%3BMercier%2C+J&rft.aulast=Ellenberger&rft.aufirst=J&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1321&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - design; engineering properties; foundations; geologic hazards; longwall mining; mining; monitoring; overburden; rock bursts; rock mechanics; safety; seismicity; stability; three-dimensional models; underground mining; United States; Utah ER - TY - JOUR T1 - A new material of grouting reinforcement for surrounding rock of roadway and its application AN - 50295680; 2003-071431 JF - Proceedings - Symposium on Rock Mechanics AU - Hou, Chaojiong AU - Zhang, Nong AU - Min, Changjiang AU - Sun, Hai A2 - Elsworth, Derek A2 - Tinucci, John P. A2 - Heasley, Keith A. Y1 - 2001 PY - 2001 DA - 2001 SP - 1035 EP - 1039 PB - A.A. Balkema, [location varies] VL - 38, Vol. 2 SN - 0586-3031, 0586-3031 KW - technology KW - engineering properties KW - cement materials KW - grouting KW - rock mechanics KW - slope stability KW - construction KW - roads KW - instruments KW - design KW - construction materials KW - consolidation KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50295680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+Symposium+on+Rock+Mechanics&rft.atitle=A+new+material+of+grouting+reinforcement+for+surrounding+rock+of+roadway+and+its+application&rft.au=Hou%2C+Chaojiong%3BZhang%2C+Nong%3BMin%2C+Changjiang%3BSun%2C+Hai&rft.aulast=Hou&rft.aufirst=Chaojiong&rft.date=2001-01-01&rft.volume=38%2C+Vol.+2&rft.issue=&rft.spage=1035&rft.isbn=9026518374&rft.btitle=&rft.title=Proceedings+-+Symposium+on+Rock+Mechanics&rft.issn=05863031&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 38th U.S. rock mechanics symposium, DC rocks 2001 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 2 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PSRMA6 N1 - SubjectsTermNotLitGenreText - cement materials; consolidation; construction; construction materials; design; engineering properties; grouting; instruments; roads; rock mechanics; slope stability; technology ER - TY - JOUR T1 - A study of the ground control effects of mining longwall faces into open or backfilled entries AN - 50293133; 2002-068729 JF - Geotechnical and Geological Engineering AU - Oyler, David C AU - Mark, Christopher AU - Dolinar, Dennis R AU - Frith, Russell C Y1 - 2001 PY - 2001 DA - 2001 SP - 137 EP - 168 PB - Kluwer, Dordrecht VL - 19 IS - 2 SN - 0960-3182, 0960-3182 KW - United States KW - mining KW - underground mining KW - multivariate analysis KW - mining geology KW - Queensland Australia KW - Australia KW - South Africa KW - Maryland KW - mines KW - failures KW - Alabama Mine A KW - overburden KW - Australasia KW - Alabama Mine C KW - Alabama Mine B KW - statistical analysis KW - coal mines KW - New South Wales Australia KW - case studies KW - longwall mining KW - Southern Africa KW - Africa KW - Pennsylvania KW - Colorado KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50293133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geotechnical+and+Geological+Engineering&rft.atitle=A+study+of+the+ground+control+effects+of+mining+longwall+faces+into+open+or+backfilled+entries&rft.au=Oyler%2C+David+C%3BMark%2C+Christopher%3BDolinar%2C+Dennis+R%3BFrith%2C+Russell+C&rft.aulast=Oyler&rft.aufirst=David&rft.date=2001-01-01&rft.volume=19&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Geotechnical+and+Geological+Engineering&rft.issn=09603182&rft_id=info:doi/ L2 - http://www.springerlink.com/app/home/journal.asp?wasp=f656ca91cf3b40e8868983de406060e5&referrer=parent&backto=linkingpublicationresults,1:100171,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 21 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Africa; Alabama Mine A; Alabama Mine B; Alabama Mine C; Australasia; Australia; case studies; coal mines; Colorado; failures; longwall mining; Maryland; mines; mining; mining geology; multivariate analysis; New South Wales Australia; overburden; Pennsylvania; Queensland Australia; South Africa; Southern Africa; statistical analysis; underground mining; United States ER - TY - JOUR T1 - MALDI-TOF mass spectrometry of bacteria* AN - 21335966; 11794187 AB - I. Introduction 172 II. Bacterial RNA and DNA 174 III. Recombinant Proteins 175 IV. Protein Identification 176 V. Proteomics 178 VI. Other Applications that Involve Cellular Isolates 180 VII. Whole Cells 180 VIII. Interpretation of Data from Whole Cells 187 IX. Identification of Proteins and Metabolites in Cells 188 X. Isolate-Related Strain Differences in Human Pathogenic Bacteria 190 XI. Conclusion and Future Prospects 190 References 191 The development of MALDI-TOF mass spectrometry methods for the characterization of bacteria is reviewed and discussed. The general use of MALDI for the characterization of large biomolecules led directly to obvious applications involving the analysis of isolated bacterial proteins. More surprising was the observation that MALDI-TOF mass spectrometry could be applied directly to crude cellular fractions or cellular suspensions and that the resulting data from such complex mixtures could provide evidence for chemotaxonomic classification. Versatility and the rapidity of analysis led to the rapid development of a number of MALDI-TOF methods involving bacteria. Examples of some of the applications covered in this review are the analysis of bacterial RNA and DNA, the detection of recombinant proteins, the characterization of targeted or unknown proteins, bacterial proteomics, the detection of virulence markers, and the very rapid characterization of bacteria at the genus, species, and strain level. The demonstrated capability of taxonomic classification at the strain level, using unprocessed cells, opens the possibility that MALDI-TOF and similar mass spectrometry approaches may contribute significantly to fulfilling emerging needs for the development of near real-time methods for the characterization of bacteria. JF - Mass Spectrometry Reviews AU - Lay Jr, Jackson O AD - Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, jlay@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 172 EP - 194 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 20 IS - 4 SN - 0277-7037, 0277-7037 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Data processing KW - RNA KW - Reviews KW - DNA KW - Metabolites KW - proteomics KW - Mass spectroscopy KW - J 02310:Genetics & Taxonomy KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21335966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mass+Spectrometry+Reviews&rft.atitle=MALDI-TOF+mass+spectrometry+of+bacteria*&rft.au=Lay+Jr%2C+Jackson+O&rft.aulast=Lay+Jr&rft.aufirst=Jackson&rft.date=2001-01-01&rft.volume=20&rft.issue=4&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Mass+Spectrometry+Reviews&rft.issn=02777037&rft_id=info:doi/10.1002%2Fmas.10003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Virulence; Data processing; RNA; Reviews; DNA; Metabolites; proteomics; Mass spectroscopy DO - http://dx.doi.org/10.1002/mas.10003 ER - TY - JOUR T1 - Influence of drug release properties of conventional solid dosage forms on the systemic exposure of highly soluble drugs AN - 21213810; 11177419 AB - This study was designed to theoretically investigate the influence of drug release properties, characterized by the disintegration of a solid dosage form and dissolution of drug particles, on the systemic exposure of highly soluble drugs in immediate release products. An absorption model was developed by considering disintegration of a solid dosage form, dissolution of drug particles, gastrointestinal transit flow, and intestinal absorption processes. The absorption model was linked to a conventional pharmacokinetic model to evaluate the effect of disintegration and dissolution on the peak exposure (Cmax) and total exposure of area under the curve (AUC). Numerical methods were used to solve the model equations. The simulations show that the effect of disintegration of a dosage form and dissolution of drug particles depend on the permeability of a drug, with a low-permeability drug having a greater effect. To provide similar exposure to an oral solution formulation, a solid dosage form containing a low-permeability drug would need to dissolve more rapidly than a solid dosage form containing a high-permeability drug. It was shown theoretically for poorly permeable drugs that the disintegration rate constant has to be greater than 9 hour (equivalent to approximately 90% in 30 minutes) to make both AUC and Cmax ratios higher than .9, ensuring the confidence interval of .80 to 1.25. The rapid in vitro release requirement of at least 85% dissolved in 30 minutes is sufficient for highly soluble and highly permeable drugs. However, for highly soluble and poorly permeable drugs, the appropriate in vitro release requirement seems to be 90% dissolved in 30 minutes. JF - AAPS Journal AU - Yu, Lawrence X AU - Ellison, Christopher D AU - Conner, Dale P AU - Lesko, Larry J AU - Hussain, Ajaz S AD - Office of Pharmaceutical Sciences, US Food and Drug Administration, 5600 Fishers Lane, 20857 Rockville, MD, vul@oder.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 86 EP - 92 PB - American Association of Pharmaceutical Scientists VL - 3 IS - 3 SN - 1550-7416, 1550-7416 KW - Toxicology Abstracts KW - Intestinal absorption KW - Drug delivery KW - Permeability KW - Mathematical models KW - Dissolution KW - Drugs KW - Pharmacokinetics KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21213810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Influence+of+drug+release+properties+of+conventional+solid+dosage+forms+on+the+systemic+exposure+of+highly+soluble+drugs&rft.au=Yu%2C+Lawrence+X%3BEllison%2C+Christopher+D%3BConner%2C+Dale+P%3BLesko%2C+Larry+J%3BHussain%2C+Ajaz+S&rft.aulast=Yu&rft.aufirst=Lawrence&rft.date=2001-01-01&rft.volume=3&rft.issue=3&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fps030324 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Intestinal absorption; Permeability; Drug delivery; Mathematical models; Dissolution; Drugs; Pharmacokinetics; Models DO - http://dx.doi.org/10.1208/ps030324 ER - TY - JOUR T1 - New Technologies for Patients with End-Stage Renal Disease: The US Regulatory Perspective AN - 21205001; 11664243 AB - The mission of the United States Food and Drag Administration (FDA) is to promote and protect public health by helping safe and effective medical products reach the market in a timely manner, and by monitoring products for continued safety after they are introduced into clinical use. The FDA has regulatory authority over both testing and marketing of medical devices in the USA. New device technologies for hemodialysis, therefore, require FDA clearance or approval prior to marketing. This chapter will describe the regulation of dialysis-related devices in the USA and provide insight into recommended preclinical and clinical testing for these products. JF - Contributions to Nephrology AU - Provost, M C AU - Meyers, C M AD - US Food and Drug Administration, Center for Devices and Radiological Health, Office of Device Evaluation, Division of Reproductive, Abdominal, and Radiological Devices, Gastroenterology and Renal Devices Branch, Rockville, Md., USA Y1 - 2001 PY - 2001 DA - 2001 SP - 10 EP - 22 VL - 133 SN - 0302-5144, 0302-5144 KW - Biotechnology and Bioengineering Abstracts KW - Medical equipment KW - Food KW - Hemodialysis KW - End-stage renal disease KW - Dialyzers KW - Public health KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21205001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+Nephrology&rft.atitle=New+Technologies+for+Patients+with+End-Stage+Renal+Disease%3A+The+US+Regulatory+Perspective&rft.au=Provost%2C+M+C%3BMeyers%2C+C+M&rft.aulast=Provost&rft.aufirst=M&rft.date=2001-01-01&rft.volume=133&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Contributions+to+Nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - SuppNotes - Dialysis, Dialyzers and Sorbents, ISBN 9783805572255. N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hemodialysis; Public health; Medical equipment; Food; Dialyzers; End-stage renal disease ER - TY - JOUR T1 - Strain-Related Differences of Nonspecific Respiratory Defense Mechanisms in Rats Using a Pulmonary Infectivity Model AN - 19253758; 5831711 AB - A number of animal studies have assessed pulmonary host defense mechanisms by inoculating the lungs with the bacterial agent, Listeria monocytogenes. Most studies use only a single strain of the animal to be tested; however, strain-related differences in responsiveness to pulmonary toxicants have been well documented. It was the goal of this current investigation to measure the pulmonary defense responses of two different strains of rats in a lung infectivity model. Fischer 344 (F344) and Sprague-Dawley (SD) rats were instilled intratracheally with 5 x 10 super(3) or 5 x 10 super(5) L. monocytogenes, and the effect on mortality, lung injury and inflammation, pulmonary bacterial clearance, and alveolar macrophage (AM) function was determined at 3, 5, and 7 days after bacteria treatment. Pulmonary inoculation with the higher (5 x 10 super(5) L. monocytogenes) dose proved to be highly pneumotoxic to the F344 rats as evidenced by an increase in mortality and more severe lung injury and inflammation when compared with the SD rats. After intratracheal instillation with the lower (5 x 10 super(3) L. monocytogenes) dose, pulmonary bacterial clearance was slowed and an increase in pulmonary responsiveness was observed for the F344 rats as compared to the SD rats. Specifically, the total number of neutrophils recovered from the lungs and tumor necrosis factor- alpha secreted by AMs were elevated for the F344 group throughout the 7 days, while cellular chemiluminescence, an index of reactive oxygen species production, and lung albumin and lactate dehydrogenase, indicators of injury, were increased at 3 and 5 days after bacterial instillation. This study demonstrated that respiratory defense function was compromised in F344 rats as evidenced by elevated mortality, slowed pulmonary bacterial clearance, and altered AM function. F344 rats may then represent a sensitive model for the examination of respiratory defense mechanisms after bacterial challenge. JF - Inhalation Toxicology AU - Antonini, J M AU - Roberts, J R AU - Clarke, R W AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 85 EP - 102 PB - Taylor & Francis Inc. VL - 13 IS - 1 SN - 0895-8378, 0895-8378 KW - rats KW - Toxicology Abstracts KW - Listeria monocytogenes KW - Lung KW - Immune system KW - Immunity KW - Defense mechanisms KW - Respiratory tract KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19253758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+Toxicology&rft.atitle=Strain-Related+Differences+of+Nonspecific+Respiratory+Defense+Mechanisms+in+Rats+Using+a+Pulmonary+Infectivity+Model&rft.au=Antonini%2C+J+M%3BRoberts%2C+J+R%3BClarke%2C+R+W&rft.aulast=Antonini&rft.aufirst=J&rft.date=2001-01-01&rft.volume=13&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Inhalation+Toxicology&rft.issn=08958378&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Listeria monocytogenes; Lung; Respiratory tract; Immune system; Defense mechanisms; Immunity ER - TY - JOUR T1 - A study of burnout in accident investigators in the US mining industry AN - 18529925; 5510660 AB - The Maslach Burnout Inventory (MBI) was administered and scored for 154 Mine Safety and Health Administration (MSHA) employees from the US Department of Labor. These employees serve as accident investigators for serious accidents and fatalities as part of their job duties. During a workshop on stress designed for them, subjects volunteered anonymous written anecdotes, confirming and illustrating the findings. The subjects represented locations across the USA and all mining commodities: coal, metal, non-metal, stone, and sand and gravel. The Maslach Burnout Inventory assesses three aspects of experienced burnout: emotional exhaustion, depersonalisation, and reduced personal accomplishments. The average results of the scores for each of the three subscales for the study group of MSHA accident investigators fell in the moderate range. These scores show that the subject population was at some risk for emotional exhaustion and depersonalisation, tending toward burnout. The group evidenced a lower sense of personal accomplishment in their jobs, indicating a higher risk for burnout. From this outcome accident investigators may be at moderate (note: this does not mean average) risk for burnout. The authors recommend follow-up with this population specifically in training to work with grieving families; and greater organisational support for the accident investigators in this area would be appropriate. JF - International Journal of Emergency Management AU - Kowalski, K M AU - Podlesny, A AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PO Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA, Kkowalski@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 VL - 1 IS - 1 SN - 1471-4825, 1471-4825 KW - accident investigators KW - burnout KW - working conditions KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18529925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Emergency+Management&rft.atitle=A+study+of+burnout+in+accident+investigators+in+the+US+mining+industry&rft.au=Kowalski%2C+K+M%3BPodlesny%2C+A&rft.aulast=Kowalski&rft.aufirst=K&rft.date=2001-01-01&rft.volume=1&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Emergency+Management&rft.issn=14714825&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Overexertion Injuries in Home Health Care Workers and the Need for Ergonomics AN - 18418847; 5402924 AB - Home health care workers have high rates of back injuries and other musculoskeletal problems. This article addresses issues surrounding work-related overexertion injuries in home health care workers, including summaries of relevant research on workers in home settings as well as in traditional health care settings such as hospitals and nursing homes. The main work factors associated with these injuries are forceful exertions and awkward postures during patient- care tasks, especially while lifting and moving patients. Ergonomics-the design of work tasks to best accommodate natural human capabilities-is the most promising approach for preventing injuries, and for enhancing the comfort and safety of workers and patients. JF - Home Health Care Services Quarterly AU - Galinsky, T AU - Waters, T AU - Malit, B AD - NIOSH, 4676 Columbia Parkway, Mail Stop C-24, Cincinnati, OH 45226, USA, tgalinsky@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 57 EP - 73 VL - 20 IS - 3 SN - 0162-1424, 0162-1424 KW - lifting KW - musculoskeletal system KW - overuse injuries KW - working conditions KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18418847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+Health+Care+Services+Quarterly&rft.atitle=Overexertion+Injuries+in+Home+Health+Care+Workers+and+the+Need+for+Ergonomics&rft.au=Galinsky%2C+T%3BWaters%2C+T%3BMalit%2C+B&rft.aulast=Galinsky&rft.aufirst=T&rft.date=2001-01-01&rft.volume=20&rft.issue=3&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Home+Health+Care+Services+Quarterly&rft.issn=01621424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Reactivity of Free Radicals on Hydroxylated Quartz Surface an Its Implications for Pathogenicity of Silicas: Experimental and Quantum Mechanic Study AN - 18346274; 5281383 AB - We studied the adsorption of hydroxyl radicals and superoxide anion radicals on a hydroxylated alpha -quartz surface using cluster and periodic slab models by means of density functional calculations. Models of two hydroxylated alpha -quartz surfaces--(0001) and (0111)--have been used in the simulations. The hydroxyl radical adsorbs readily on both surfaces. The subsurface Si-O bonds are weakened during the adsorption resulting in surface layer destabilization. This destabilization leads directly to surface disintegration in the case of times OH/(0111) adsorption. The product of the surface disintegration and reconstruction is a surface terminated by silanol groups (Si-OH) and siloxyl radicals (Si-O times ). The model calculations suggest that adsorption of times OH on a hydroxylated quartz surface transforms a chemically inert, aged, silanol terminated surface to a very reactive, silicon-based radical terminated surface. The activated surface may then cause oxidative damage to the adsorbed biomaterial. The superoxide anion radical adsorbs on both surfaces, but the adsorption products are only weakly bonded to the surface. The calculated energy barrier for the O times sub(2) super(-) activated subsurface Si-O bond dissociation is 10 kcal/mol, which is higher than for the times OH activated process (4 kcal/mol). The calculated weaker bonding to the surface and higher activation energy barrier suggest that the superoxide anion radical will be less efficient in reactivation of an aged, hydroxylated quartz surface than the hydroxyl radical. The importance of the specific geometry of the surface silicon atoms on the surface reactivity and adsorption properties is also discussed. The theoretical predictions are supported experimentally using chemiluminescence to monitor reactivation of the aged silica surface by superoxide anion radicals. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Konencny, R AU - Leonard, S AU - Shi, X AU - Robinson, V AU - Castranova, V AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505-2888, USA, VCastranova@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 119 EP - 132 PB - Begell House Inc. VL - 20 SN - 0731-8898, 0731-8898 KW - surface absorption KW - hydroxyl KW - Toxicology Abstracts KW - Silica KW - Pathogenicity KW - Free radicals KW - Models KW - Silicon dioxide KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18346274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Reactivity+of+Free+Radicals+on+Hydroxylated+Quartz+Surface+an+Its+Implications+for+Pathogenicity+of+Silicas%3A+Experimental+and+Quantum+Mechanic+Study&rft.au=Konencny%2C+R%3BLeonard%2C+S%3BShi%2C+X%3BRobinson%2C+V%3BCastranova%2C+V&rft.aulast=Konencny&rft.aufirst=R&rft.date=2001-01-01&rft.volume=20&rft.issue=&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Silica; Free radicals; Pathogenicity; Silicon dioxide; Models ER - TY - JOUR T1 - Genotoxicity of Iron Chelators in L5178Y Mouse Lymphoma Cells AN - 18316083; 5361925 AB - To further study the mechanism of observed iron mutagenicity and cellular toxicity, a number of different iron chelators were evaluated to select a compound that was not mutagenic and had limited toxicity to mouse lymphoma cells. A series of iron chelators including those used clinically, those under development for clinical applications, and those used in nonclinical applications were evaluated. The mutagenic activity of the iron chelators was assessed in L5178Y mouse lymphoma cells. Eight of the 12 iron chelators that were tested induced mutagenic responses both with and without the addition of S9. Among those chelators used clinically or developed for clinical use, the only compound that did not induce a mutagenic response was the starch deferoxamine conjugate. In contrast, deferoxamine mesylate showed the highest toxicity in this group of chemicals and the concentrations leading to toxicity and mutagenicity between the activated and nonactivated assays were not significantly different. The other three chelators that were not mutagenic were Na sub(2)EDTA, phytic acid, and ferrozine. JF - Environmental and Molecular Mutagenesis AU - Whittaker, P AU - Seifried, HE AU - San, RHC AU - Clarke, J J AU - Dunkel, V C AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration (HFS-236), 200 C Street, S.W., Washington, DC 20204, USA, paul.whittaker@cfsan.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 347 EP - 356 VL - 38 IS - 4 SN - 0893-6692, 0893-6692 KW - mice KW - deferoxamine mesylate KW - Genetics Abstracts; Toxicology Abstracts KW - Mutagenicity KW - Genotoxicity KW - Chelating agents KW - Iron KW - Toxicity testing KW - X 24117:Biochemistry KW - G 07220:General theory/testing systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18316083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Genotoxicity+of+Iron+Chelators+in+L5178Y+Mouse+Lymphoma+Cells&rft.au=Whittaker%2C+P%3BSeifried%2C+HE%3BSan%2C+RHC%3BClarke%2C+J+J%3BDunkel%2C+V+C&rft.aulast=Whittaker&rft.aufirst=P&rft.date=2001-01-01&rft.volume=38&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.10033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Toxicity testing; Chelating agents; Iron; Genotoxicity; Mutagenicity DO - http://dx.doi.org/10.1002/em.10033 ER - TY - JOUR T1 - Uptake and distribution of mercury in rats after repeated administration of mercuric chloride AN - 18312870; 5375589 AB - This investigation was under taken to evaluate the effect of repeated exposure of mercuric chloride (MC) on food consumption, body weight gain and tissue distribution of mercury in rats. After two weeks of acclimation, male and female rats (45-50 days old) were orally gavaged with 0.00, 2.0, 4.0 6.0, 8.0 or 10.0 mg/kg/day of MC for 14 consecutive days. The mortality and food consumption were recorded daily. The body weight gains were recorded on day 0, 4, 7, 10, and at day of termination. At the end of the experiment, all surviving rats were euthanized and tissue samples from their brains, gonads, hearts, kidneys, livers, lungs, pancreases and spleens were collected and analyzed for mercury content. Exposure of male and female rats to 4.0 mg/kg/day of MC showed a significant reduction in body weight gain and food consumption when compared to their controls. However, at 2.0 mg/kg/day dose group showed no change of body gain and food consumption. The mercury contents in brains, gonads, hearts, and spleens of male and female rats at 0.0 and 2.0 mg/kg/day were undetectable. Both male and female rats accumulated significantly more mercury in the kidneys than the other organs. Mercury content in the kidneys of females was 39.9 and 40.9 mu g/g at 2.0 and 4.0 mg/kg/day, respectively and of males was 34.9 and 41.0 mu g/g at 2.0 and 4.0 mg/kg/day, respectively. However, mercury content in the kidneys and livers of males and females did not show any significant difference. Mercury content in the kidneys of both of sexes was significantly higher than the other organs. JF - Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering AU - Khan, A T AU - Atkinson, A AU - Graham, T C AU - Shireen, K F AD - IS FDA-CFSAN, 200 C St., SW, HFS-207, Washington, DC 20204, USA, Akhan@cfsan.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 2039 EP - 2045 VL - A36 IS - 10 SN - 1093-4529, 1093-4529 KW - rats KW - distribution KW - uptake KW - Toxicology Abstracts KW - Mercuric chloride KW - Heavy metals KW - Mercury KW - X 24163:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18312870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+A%3A+Toxic%2FHazardous+Substances+%26+Environmental+Engineering&rft.atitle=Uptake+and+distribution+of+mercury+in+rats+after+repeated+administration+of+mercuric+chloride&rft.au=Khan%2C+A+T%3BAtkinson%2C+A%3BGraham%2C+T+C%3BShireen%2C+K+F&rft.aulast=Khan&rft.aufirst=A&rft.date=2001-01-01&rft.volume=A36&rft.issue=10&rft.spage=2039&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+A%3A+Toxic%2FHazardous+Substances+%26+Environmental+Engineering&rft.issn=10934529&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mercury; Mercuric chloride; Heavy metals ER - TY - JOUR T1 - Neurobehavioral test performance in the third National Health and Nutrition Examination Survey AN - 18299621; 5348208 AB - The third National Health and Nutrition Examination Survey (NHANES III) contained three computerized neurobehavioral tests from the Neurobehavioral Evaluation System (NES): simple reaction time, symbol-digit substitution and serial digit learning. The neurobehavioral data that were collected came from a nationally representative sample of adults 20-59 years old. Performance on the tests was related to sex, age, education level, family income and race-ethnicity. Performance decreased as age increased, and increased as education level and family income increased. Differences in performance between sexes, levels of education and racial-ethnic groups tended to decrease as family income increased. The relationship between age and performance on the symbol-digit substitution test varied by education level and by racial-ethnic group. The relationship between age and performance on the serial digit learning test varied by racial-ethnic group. Questionnaire variables that were related to performance on one or more of the tests included the reported amount of last night's sleep, energy level, computer or video game familiarity, alcoholic beverages within the last 3 h and effort. Persons who took the tests in English or Spanish performed differently on the symbol-digit substitution and serial digit learning tests. Performance on all the tests decreased as test room temperature increased. JF - Neurotoxicology and Teratology AU - Krieg, EF Jr AU - Chrislip, D W AU - Letz, R E AU - Otto, DA AU - Crespo, C J AU - Brightwell, W S AU - Ehrenberg, R L AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 569 EP - 589 VL - 23 IS - 6 SN - 0892-0362, 0892-0362 KW - lifestyles KW - man KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Socio-economic aspects KW - Education KW - Age KW - Testing KW - Learning behavior KW - X 24240:Miscellaneous KW - N3 11047:Neuropsychobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18299621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Neurobehavioral+test+performance+in+the+third+National+Health+and+Nutrition+Examination+Survey&rft.au=Krieg%2C+EF+Jr%3BChrislip%2C+D+W%3BLetz%2C+R+E%3BOtto%2C+DA%3BCrespo%2C+C+J%3BBrightwell%2C+W+S%3BEhrenberg%2C+R+L&rft.aulast=Krieg&rft.aufirst=EF&rft.date=2001-01-01&rft.volume=23&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Learning behavior; Socio-economic aspects; Age; Education; Testing ER - TY - JOUR T1 - Global Forum on TB Vaccine Research and Development. World Health Organization, June 7-8 2001, Geneva AN - 18290197; 5341652 AB - The TB community now envisions a turning point in the development of improved TB vaccines for both high and low incidence countries. With a number of viable TB vaccine candidates now available for testing, the investigation of safety and immunogenicity in human clinical trials is seen as the driving force for the future development of effective vaccines for the prevention of tuberculosis. JF - Tuberculosis AU - Brennan, MJ AU - Fruth, U AD - Building 29 Room 502, 29 Lincoln Drive (HFM-431), Bethesda, MD 20892, USA, brennan@cber.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 365 EP - 368 VL - 61 IS - 5-6 SN - 1472-9792, 1472-9792 KW - Microbiology Abstracts B: Bacteriology KW - Immunogenicity KW - Tuberculosis KW - Vaccines KW - Research programs KW - Mycobacterium tuberculosis KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18290197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tuberculosis&rft.atitle=Global+Forum+on+TB+Vaccine+Research+and+Development.+World+Health+Organization%2C+June+7-8+2001%2C+Geneva&rft.au=Brennan%2C+MJ%3BFruth%2C+U&rft.aulast=Brennan&rft.aufirst=MJ&rft.date=2001-01-01&rft.volume=61&rft.issue=5-6&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Tuberculosis&rft.issn=14729792&rft_id=info:doi/10.1054%2Ftube.2001.0308 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Vaccines; Tuberculosis; Research programs; Immunogenicity DO - http://dx.doi.org/10.1054/tube.2001.0308 ER - TY - JOUR T1 - Infective dose of foodborne pathogens in volunteers: A review AN - 18280233; 5338883 AB - Risk assessment and impact of foodborne pathogens on the health of different populations was one of the goals identified in the Presidential Food Safety Initiative three-year plan. This entailed estimation of dose-response relationship for foodborne pathogens to humans, either by feeding studies or from outbreaks. For certain pathogens, such as Listeria monocytogenes and Escherichia coli O157:H7, there are no feeding studies due to ethical reasons, and the results from outbreaks are normally used to estimate the infectious dose. The focus of this review is to compile dose-response information in volunteers for several foodborne pathogens including Salmonella, Shigella spp., Campylobacter jejuni, Vibrio spp., Escherichia coli, Cryptosporidium parvum and Entamoeba coli. The infectious dose for different servors of Salmonella and strains of E. coli was quite large (> 10 super(5) organisms), while the infectious dose for some Shigella spp. seemed to be as low as less than 10 organisms. Toxigenic V. cholerae (O1 and O139 serotypes) were infective at a dose of 10 super(4) organisms; a non-O1 strain was infective at a much higher dose (10 super(6) organisms). C. jejuni, C. parvum and Entamoeba coli appeared to have infectious doses as low as 500 organisms, 10 oocysts, and 1 cyst, respectively. The infectious dose and the dose response are dependent upon the strains used, and the age and physical condition of the individuals, and can therefore show wide variations. In addition, since many of the volunteer studies are carried out by feeding the organisms in a nonfood matrix after neutralizing the stomach acidity, results obtained may not reflect the true dose response. JF - Journal of Food Safety AU - Kothary, M H AU - Babu, U S AD - U.S. Food and Drug Administration, Division of Virulence Assessment, 200 C Street, S.W., Washington, DC 20204, USA, mkothary@cfsan.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 49 EP - 73 VL - 21 IS - 1 SN - 0149-6085, 0149-6085 KW - food-borne diseases KW - outbreaks KW - Health & Safety Science Abstracts KW - Risk assessment KW - Listeria monocytogenes KW - Reviews KW - Escherichia coli KW - Pathogens KW - Food contamination KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18280233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Safety&rft.atitle=Infective+dose+of+foodborne+pathogens+in+volunteers%3A+A+review&rft.au=Kothary%2C+M+H%3BBabu%2C+U+S&rft.aulast=Kothary&rft.aufirst=M&rft.date=2001-01-01&rft.volume=21&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Safety&rft.issn=01496085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Listeria monocytogenes; Escherichia coli; Food contamination; Risk assessment; Reviews; Pathogens ER - TY - BOOK T1 - FDA Initiatives in HAB and Marine Biotoxins AN - 18269764; 5323459 AB - First I'd like to acknowledge a very important contribution made by a few people to a key study done in the wake of the 1994 PSP outbreak in Kodiak, Alaska. Fortunately samples were obtained and made available to us for analysis, thanks to the good work of Brad Gessner and Dick Barrett. The samples were from shellfish and the human victims, and the analyses were very revealing. JF - Harmful Algal Blooms on the North American West Coast AU - Hall, S A2 - RaLonde, R (ed) Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 6 EP - 16 PB - University of Alaska Sea Grant, P.O. Box 755040 205 O'Neill Bldg Fairbanks Ak 99775 USA SN - 1566120713 KW - saxitoxin KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine KW - Algal blooms KW - Human diseases KW - INE, USA, Alaska, Kodiak I. KW - Phytoplankton KW - Food poisoning KW - Public health KW - Alexandrium KW - Health and safety KW - Shellfish KW - Seafood KW - Neurotoxins KW - Chemical analysis KW - Paralytic shellfish poisoning KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18269764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hall%2C+S&rft.aulast=Hall&rft.aufirst=S&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=11&rft.isbn=1566120713&rft.btitle=FDA+Initiatives+in+HAB+and+Marine+Biotoxins&rft.title=FDA+Initiatives+in+HAB+and+Marine+Biotoxins&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-07 ER - TY - JOUR T1 - Three R's of Bacterial Evolution: How Replication, Repair, and Recombination Frame the Origin of Species AN - 18256973; 5316477 AB - The genetic diversity of bacteria results not only from errors in DNA replication and repair but from horizontal exchange and recombination of DNA sequences from similar and disparate species as well. New individuals carrying adaptive changes are thus being spawned constantly among the population at large. When new selection pressures appear, these are the individuals that survive, at the expense of the general population, to forge new populations. Depending on the severity and uniqueness of the selection pressure, this could lead to new speciation. It is becoming more and more evident that, as nucleotide sequences of numerous loci from many bacterial strains continue to amass, horizontal transfer has played a key role in configuring the Escherichia coli chromosome. Here, we examine views, both old and new, for the role of recombination in the evolution of bacterial chromosomes. We present novel phylogenetic evidence for horizontal transfer of three genes involved in DNA replication and repair (mutS, uvrD, and polA). These data reveal a prominent role for horizontal transfer in the evolution of genes known to play a key role in the fidelity of DNA replication and, thus, ultimate survival of the organism. Our data underscore that recombination plays both a diversifying and a homogenizing role in defining the structure of the E. coli genome. JF - Environmental and Molecular Mutagenesis AU - Brown, E W AU - LeClerc, JE AU - Kotewicz, M L AU - Cebula, T A AD - Division of Molecular Biology (HFS-235), Center for Food Safety & Applied Nutrition, U.S. Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA, tcebula@cfsan.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 248 EP - 260 VL - 38 IS - 2-3 SN - 0893-6692, 0893-6692 KW - mutS gene KW - polA gene KW - uvrD gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - DNA biosynthesis KW - Genetic diversity KW - DNA repair KW - Horizontal transfer KW - Recombination KW - Chromosomes KW - Escherichia coli KW - Evolution KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution KW - G 07260:Taxonomy, systematics and evolutionary genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18256973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Three+R%27s+of+Bacterial+Evolution%3A+How+Replication%2C+Repair%2C+and+Recombination+Frame+the+Origin+of+Species&rft.au=Brown%2C+E+W%3BLeClerc%2C+JE%3BKotewicz%2C+M+L%3BCebula%2C+T+A&rft.aulast=Brown&rft.aufirst=E&rft.date=2001-01-01&rft.volume=38&rft.issue=2-3&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.1079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Evolution; DNA repair; DNA biosynthesis; Recombination; Genetic diversity; Chromosomes; Horizontal transfer DO - http://dx.doi.org/10.1002/em.1079 ER - TY - JOUR T1 - Cutaneous metabolism during in vitro percutaneous absorption AN - 18256291; 5316273 AB - The skin is a portal of entry and the largest organ of the body. It has been shown to contain the major enzymes found in other tissues of the body. Topically applied compounds may be metabolized in skin resulting in altered pharmacologic or toxicologic activity. The metabolism of benzo[a]pyrene applied to mouse skin floating in an organ culture demonstrated the potential importance of metabolism of chemicals during percutaneous absorption. A flow-through diffusion cell was subsequently developed to aid in quantitating skin absorption and metabolism. Viability of skin in the diffusion cell, which was assessed by light microscopy, was found to be maintained for at least 17 h. The viability of pig skin was maintained in flow-through cells by using tissue culture media; skin-mediated hydrolysis of diethyl malonate was observed. The suitability of these conditions to maintain skin viability was assessed in initial studies by the ability to graft the skin to nude mice. JF - Journal of Toxicology: Cutaneous and Ocular Toxicology AU - Bronaugh, R L AU - Kraeling, MEK AU - Yourick, J J AU - Hood, H L AD - Food and Drug Administration, Laurel, Maryland, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 271 EP - 277 VL - 20 IS - 2-3 SN - 0731-3829, 0731-3829 KW - diffusion cell KW - pigs KW - mice KW - metabolism KW - flow-through cells KW - in vitro percutaneous absorption KW - diethyl malonate KW - Toxicology Abstracts KW - Skin KW - Bioaccumulation KW - Benzo(a)pyrene KW - Organ culture KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18256291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology%3A+Cutaneous+and+Ocular+Toxicology&rft.atitle=Cutaneous+metabolism+during+in+vitro+percutaneous+absorption&rft.au=Bronaugh%2C+R+L%3BKraeling%2C+MEK%3BYourick%2C+J+J%3BHood%2C+H+L&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=2001-01-01&rft.volume=20&rft.issue=2-3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology%3A+Cutaneous+and+Ocular+Toxicology&rft.issn=07313829&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Benzo(a)pyrene; Organ culture; Bioaccumulation; Skin ER - TY - JOUR T1 - Genotoxic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides - Mechanisms leading to DNA adduct formation and tumorigenicity AN - 18253792; 5314970 AB - Plants that contain pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides are widely distributed in the world. These plants are probably the most common poisonous plants affecting livestock, wildlife, and humans. Although pyrrolizidine alkaloids have been shown to be genotoxic, including tumorigenic in experimental animals, the mechanisms of tumor formation have not been fully understood. Our recent studies on riddelliine, riddelline N-oxide, and dehydroretronecine (DHR) provided evidence suggesting that pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides induce tumors via a genotoxic mechanism, and that tumorigenicity is mediated by a set of eight DHR-derived DNA adducts. This mechanism may be general to other carcinogenic pyrrolizidine alkaloids and may also be responsible for the other genotoxicities of pyrrolizidine alkaloids, including mutagenicity and teratogenicity. It is hypothesized that these DHR-derived DNA adducts are potential biomarkers of pyrrolizidine alkaloid tumorigenicity. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Fu, P P AU - Chou, M W AU - Xia, Q AU - Yang, Y-C AU - Yan, J AU - Doerge AU - Chan, P C AD - National Center for Toxicological Research, Jefferson, AR 72079, USA, pfu@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 353 EP - 385 VL - C19 IS - 2 SN - 1059-0501, 1059-0501 KW - man KW - dehydroretronecine KW - pyrrolizidine alkaloid N-oxides KW - pyrrolizidine alkaloids KW - Toxicology Abstracts KW - DNA adducts KW - Alkaloids KW - Wildlife KW - Plants KW - Poisoning KW - Tumors KW - Carcinogens KW - Livestock KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18253792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Genotoxic+pyrrolizidine+alkaloids+and+pyrrolizidine+alkaloid+N-oxides+-+Mechanisms+leading+to+DNA+adduct+formation+and+tumorigenicity&rft.au=Fu%2C+P+P%3BChou%2C+M+W%3BXia%2C+Q%3BYang%2C+Y-C%3BYan%2C+J%3BDoerge%3BChan%2C+P+C&rft.aulast=Fu&rft.aufirst=P&rft.date=2001-01-01&rft.volume=C19&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Carcinogens; Livestock; Wildlife; Poisoning; DNA adducts; Tumors; Plants; Alkaloids ER - TY - JOUR T1 - Determination of percutaneous absorption by in vitro techniques AN - 18253687; 5316280 AB - In vitro percutaneous absorption methods have become widely used for measuring the absorption of compounds that come in contact with skin. Safety evaluations of toxic chemicals frequently rely on in vitro studies for human permeation data. Animal data must be used cautiously for estimating human absorption due to differences in barrier properties of animal and human skin. In vitro absorption studies can also be used to measure skin metabolism if viable skin is obtained for the study and if the viability is maintained in the diffusion cells. The in vitro system allows for the isolation of skin so that metabolism of the organ can be distinguished from systemic metabolism. Important considerations is conducting in vitro absorption studies are discussed in the following sections. JF - Journal of Toxicology: Cutaneous and Ocular Toxicology AU - Bronaugh, R L AU - Hood, H L AU - Kraeling, MEK AU - Yourick, J J AD - Food and Drug Administration, Laurel, Maryland, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 423 EP - 427 VL - 20 IS - 4 SN - 0731-3829, 0731-3829 KW - metabolism KW - in vitro KW - percutaneous absorption KW - Toxicology Abstracts KW - Skin KW - Toxicity testing KW - Organ culture KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18253687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology%3A+Cutaneous+and+Ocular+Toxicology&rft.atitle=Determination+of+percutaneous+absorption+by+in+vitro+techniques&rft.au=Bronaugh%2C+R+L%3BHood%2C+H+L%3BKraeling%2C+MEK%3BYourick%2C+J+J&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=2001-01-01&rft.volume=20&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology%3A+Cutaneous+and+Ocular+Toxicology&rft.issn=07313829&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Organ culture; Toxicity testing; Skin ER - TY - JOUR T1 - Biological and Statistical Approaches to Predicting Human Lung Cancer Risk from Silica AN - 18227828; 5281374 AB - Chronic inflammation is a key step in the pathogenesis of particle-elicited fibrosis and lung cancer in rats, and possibly in humans. In this study, we compute the excess risk estimates for lung cancer in humans with occupational exposure to crystalline silica, using both rat and human data, and using both a threshold approach and linear models. From a toxicokinetic/dynamic model fit to lung burden and pulmonary response data from a subchronic inhalation study in rats, we estimated the minimum critical quartz lung burden (M sub(crit)) associated with reduced pulmonary clearance and increased neutrophilic inflammation. A chronic study in rats was also used to predict the human excess risk of lung cancer at various quartz burdens, including mean M sub(crit) (0.39 mg/g lung). We used a human kinetic lung model to link the equivalent lung burdens to external exposures in humans. We then computed the excess risk of lung cancer at these external exposures, using data of workers exposed to respirable crystalline silica and using Poisson regression and lifetable analyses. Finally, we compared the lung cancer excess risks estimated from male rat and human data. We found that the ratbased linear model estimates were approximately three times higher than those based on human data (e.g., 2.8% in rats vs. 0.9-1% in humans, at mean M sub(crit) lung burden or associated mean working lifetime exposure of 0.036 mg/m super(3)). Accounting for variability and uncertainty resulted in 100-1000 times lower estimates of human critical lung burden and airborne exposure. This study illustrates that assumptions about the relevant biological mechanism, animal model, and statistical approach can all influence the magnitude of lung cancer risk estimates in humans exposed to crystalline silica. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Kuempel, ED AU - Tran, C-L AU - Bailer, A J AU - Porter, D W AU - Hubbs, A F AU - Castranova, V AD - Risk Evaluation Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway M.S.C-15 Cincinnati, OH 45226-1998, USA, ekuempel@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 15 EP - 32 PB - Begell House Inc. VL - 20 SN - 0731-8898, 0731-8898 KW - man KW - Toxicology Abstracts KW - Risk assessment KW - Mathematical models KW - Silica KW - Lung KW - Occupational exposure KW - Cancer KW - Silicon dioxide KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18227828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Biological+and+Statistical+Approaches+to+Predicting+Human+Lung+Cancer+Risk+from+Silica&rft.au=Kuempel%2C+ED%3BTran%2C+C-L%3BBailer%2C+A+J%3BPorter%2C+D+W%3BHubbs%2C+A+F%3BCastranova%2C+V&rft.aulast=Kuempel&rft.aufirst=ED&rft.date=2001-01-01&rft.volume=20&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Silica; Silicon dioxide; Mathematical models; Risk assessment; Lung; Cancer; Occupational exposure ER - TY - JOUR T1 - IgG Subclass Responses in Experimental Silicosis AN - 18225230; 5281378 AB - Silicosis is a crippling fibrotic lung disease induced by inhaling crystalline silica. In addition to fibrosis, silica inhalation by humans is associated with a number of immunological effects including increased levels of serum immunoglobulins (in particular IgG), increased prevalence of autoantibodies, and autoimmune disease. Recent studies using rodent models have shown that experimental silicosis is associated with a T-helper (T sub(H))1 pattern of T-cell activation in the lungs and lung-associated lymph nodes after silica inhalation, which are also the sites of increased IgG production. We therefore hypothesized that the subclass distribution of IgG production occurring in experimental silicosis would suggest T sub(H)1 activation as the primary stimulus for IgG production. Using an ELISPOT assay, we found increased IgG-secreting spot-forming cells of all IgG subclasses in lung-associated lymph nodes taken from silica-exposed rats 3 to 4 months after aerosol exposure to silica. Neither T sub(H)1- nor T sub(H)2-dependent IgG subclass-secreting cells were selectively enhanced. Our findings suggest that T sub(H)1 activation alone does not account for increased production of IgG in experimental silicosis. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Weissman, D N AU - Hubbs, A F AU - Huang, S-H AU - Stanley, C F AU - Rojanasakul, Y AU - Ma, JKH AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Analytical Services Branch 1095 Willowdale Rd., Morgantown WV 26505, USA, dqw4@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 67 EP - 74 PB - Begell House Inc. VL - 20 SN - 0731-8898, 0731-8898 KW - rats KW - Toxicology Abstracts KW - Inhalation KW - Aerosols KW - Silica KW - Lung KW - Silicosis KW - Immunoglobulin G KW - Lymphocytes T KW - Lymph nodes KW - Silicon dioxide KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18225230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=IgG+Subclass+Responses+in+Experimental+Silicosis&rft.au=Weissman%2C+D+N%3BHubbs%2C+A+F%3BHuang%2C+S-H%3BStanley%2C+C+F%3BRojanasakul%2C+Y%3BMa%2C+JKH&rft.aulast=Weissman&rft.aufirst=D&rft.date=2001-01-01&rft.volume=20&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Silica; Inhalation; Aerosols; Silicon dioxide; Lymph nodes; Lung; Silicosis; Lymphocytes T; Immunoglobulin G ER - TY - JOUR T1 - The effects of restricted workspace on lumbar spine loading AN - 18217053; 5293058 AB - Coal miners often handle heavy electrical power cables, weighing up to 10 kg per meter. These cables are manually lifted and attached to the mine roof to prevent damage from mobile underground equipment. Data suggest that workers who commonly perform cable-handling tasks experience a high rate of lost-time back injuries. In this study, six male underground miners performed a total of 12 cable-hanging tasks in standing, stooping, and kneeling postures, during which kinematic and ground reaction force data were collected. Reductions in vertical workspace were found to result in a linear increase in the peak moment experienced by the lumbar spine (p 0.05). Average lumbopelvic flexion during the tasks was highest in stooping conditions. followed by standing and kneeling exertions (p < 0.05). Implications of this data with respect to design of cable handling tasks are presented and discussed. JF - Occupational Ergonomics AU - Gallagher, S AU - Hamrick, CA AU - Cornelius, K M AU - Redfern AD - National Institute for Occupational Safety and Health (NIOSH), P.O. Box 18070, Pittsburgh, PA, USA, sfg9@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 201 EP - 213 VL - 2 IS - 4 SN - 1359-9364, 1359-9364 KW - electric cables KW - loading KW - spine KW - Health & Safety Science Abstracts KW - Materials handling KW - Occupational safety KW - Mining KW - Coal KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18217053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Ergonomics&rft.atitle=The+effects+of+restricted+workspace+on+lumbar+spine+loading&rft.au=Gallagher%2C+S%3BHamrick%2C+CA%3BCornelius%2C+K+M%3BRedfern&rft.aulast=Gallagher&rft.aufirst=S&rft.date=2001-01-01&rft.volume=2&rft.issue=4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Occupational+Ergonomics&rft.issn=13599364&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; Coal; Mining; Materials handling ER - TY - JOUR T1 - Detection of DNA Strand Breaks, DNA-Protein Crosslinks, and Telomerase Activity in Nickel-Transformed BALB/c-3T3 Cells AN - 18213238; 5280817 AB - Although nickel compounds are known carcinogens, the underlying carcinogenic mechanisms are not fully understood. The objective of this research was to determine if the genotoxic lesions of DNA strand breaks and DNA-protein crosslinks are present in nickel-transformed BALB/c-3T3 cells, and to further elucidate the potential carcinogenesis of insoluble and soluble nickel compounds through telomerase activity in nickel-transformed BALB/c-3T3 cell lines. DNA strand breaks, DNA-protein crosslinks and telomerase activity were investigated by single cell gel electrophoresis (comet assay), super(125)I-postlabelling techniques, and the TRAP-silver staining assay, respectively. Results showed that both DNA strand breaks and DNA-protein crosslinks were present in nickel-transformed BALB/c-3T3 cells. However, the highest levels of DNA strand breaks and DNA-protein crosslinks were found in insoluble crystalline NiS-transformed cells and high levels of DNA strand breaks and DNA-protein crosslinks were also found in the transformed cells induced by two water-soluble NiCl sub(2) and NiSO sub(4) at moderate concentrations of cytotoxicity. These data suggest that these two genetic endpoints are useful biomarkers and are associated with cell transformation and carcinogensis of insoluble and soluble nickel compounds. Also, we found that the crystalline NiS- and NiCl sub(2)-transformed cells possessed a high telomerase activity. A weak telomerase was found in NiSO sub(4)-transformed cells. The results seem to indicate that in addition to crystalline NiS, some water-soluble nickel compounds such as NiCl sub(2) are also highly carcinogenic. These results may partly explain the cell transformation and relative carcinogenic potency of insoluble crystalline NiS, soluble NiCl sub(2), and NiSO sub(4). JF - Teratogenesis, Carcinogenesis and Mutagenesis AU - Lei, Yi-xiong AU - Chen, Jia-kun AU - Wu, Zhong-liang AD - Toxicology and Molecular Biology Branch, HELD, NIOSH, m/s 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA, ybl3@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 463 EP - 471 VL - 21 IS - 6 SN - 0270-3211, 0270-3211 KW - breaks KW - DNA strand breaks KW - Genetics Abstracts; Toxicology Abstracts KW - Transformation KW - Heavy metals KW - Telomerase KW - Nickel KW - Genotoxicity KW - Carcinogens KW - DNA damage KW - Comet assay KW - X 24165:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18213238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+Carcinogenesis+and+Mutagenesis&rft.atitle=Detection+of+DNA+Strand+Breaks%2C+DNA-Protein+Crosslinks%2C+and+Telomerase+Activity+in+Nickel-Transformed+BALB%2Fc-3T3+Cells&rft.au=Lei%2C+Yi-xiong%3BChen%2C+Jia-kun%3BWu%2C+Zhong-liang&rft.aulast=Lei&rft.aufirst=Yi-xiong&rft.date=2001-01-01&rft.volume=21&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+Carcinogenesis+and+Mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Genotoxicity; Transformation; DNA damage; Telomerase; Nickel; Heavy metals; Carcinogens; Comet assay ER - TY - JOUR T1 - Asthma Outcomes at an Inner-City School-Based Health Center AN - 18153770; 4876153 AB - Childhood asthma has reached near-epidemic levels in the US cities. Innovative strategies to identify children with asthma and prevent asthma morbidity are needed. This study measured asthma outcomes after initiation of an inner-city elementary school health center with a schoolwide focus on asthma detection and treatment. The site was an inner-city elementary school in Minneapolis, Minn. The study design incorporated a pre and post comparison with a longitudinal cohort of children (n=67) and a cross-sectional cohort of children before (n=156) and after (n=114) the intervention. Hospitalization rates for asthma decreased 75% to 80% over the study period. Outpatient visits for care in the absence of asthma symptoms doubled (p<.01), and the percentage of students seeing a specialist for asthma increased (p<.01). Use of peak flow meters, use of asthma care plans, and use of inhalers also improved (p<.01). While no change occurred in school absenteeism, parents reported that their children had less awakening with asthma and that asthma was less disruptive to family plans. This schoolwide intervention that included identification of children with asthma, education, family support, and clinical care using an elementary school health center was effective in improving asthma outcomes for children. JF - Journal of School Health AU - Lurie, N AU - Bauer, E J AU - Brady, C AD - US Department of Health and Human Services, 200 Independence Ave., SW, Room 716-G, Washington, DC 20201, USA, nlurie@osophs.dhhs.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 9 EP - 16 VL - 71 IS - 1 SN - 0022-4391, 0022-4391 KW - Physical Education Index KW - Elementary schools KW - Asthma KW - Children KW - Urban environment KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18153770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Health&rft.atitle=Asthma+Outcomes+at+an+Inner-City+School-Based+Health+Center&rft.au=Lurie%2C+N%3BBauer%2C+E+J%3BBrady%2C+C&rft.aulast=Lurie&rft.aufirst=N&rft.date=2001-01-01&rft.volume=71&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Elementary schools; Asthma; Children; Urban environment ER - TY - JOUR T1 - Part 1. Report from the Food and Drug Administration, Infections Related to Breast Implants Reported to the Food and Drug Administration, 1977-1997 AN - 18149731; 5166511 AB - The FDA has a surveillance system for monitoring adverse events related to medical devices. Infection reports submitted to the FDA by breast implant manufacturers between 1977 and 1997 are characterized. Two cases of death caused by toxic shock syndrome after mammoplasty reported to the FDA are presented. Overall, 1,971 reports with a principal adverse event of infection were reported in this time frame. There was a large increase in the number of reports on infections related to breast implants between 1992 and 1995 due to the publicity and litigation surrounding breast implants. When an organism was identified in the report, the most common organism reported was Staphylococcus sp. Information on the time between the implantation and the onset of the infection or the explantation of the implant was not always reported. However, in reports that did contain this information, there were differences between the length of time to infection onset reported for saline breast implants (earlier) compared to silicone gel breast implants (later). More than half of the reports (56.6%) asserted only that there was an infection and that breast implants were explanted as a result; the remaining reports asserted that infection and other signs, symptoms, or diagnoses had afflicted the patient. JF - Journal of Long-Term Effects of Medical Implants AU - Brown, S L AU - Hefflin, B AU - Woo, E K AU - Parmentier, C M AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Drive, HFZ-541, Rockville, MD 20850, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 1 EP - 12 VL - 11 IS - 1-2 SN - 1050-6934, 1050-6934 KW - infection KW - man KW - USA, Food and Drug Administration KW - breast implants KW - toxic shock syndrome KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Breast KW - Staphylococcus KW - Government policy KW - Databases KW - USA KW - Implants KW - Toxic shock syndrome KW - Side effects KW - J 02855:Human Bacteriology: Others KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18149731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Long-Term+Effects+of+Medical+Implants&rft.atitle=Part+1.+Report+from+the+Food+and+Drug+Administration%2C+Infections+Related+to+Breast+Implants+Reported+to+the+Food+and+Drug+Administration%2C+1977-1997&rft.au=Brown%2C+S+L%3BHefflin%2C+B%3BWoo%2C+E+K%3BParmentier%2C+C+M&rft.aulast=Brown&rft.aufirst=S&rft.date=2001-01-01&rft.volume=11&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Long-Term+Effects+of+Medical+Implants&rft.issn=10506934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus; USA; Side effects; Mortality; Implants; Toxic shock syndrome; Breast; Government policy; Databases ER - TY - JOUR T1 - Genetic Variation in Mitochondrial DNA of North American Herring Gulls, Larus argentatus AN - 18077858; 5160092 AB - The herring gull (Larus argentatus), which is one of the most abundant gulls in temperate North America, is used as an important bioindicator species, but little is known about its patterns of genetic variation. This study examines DNA sequence diversity in the cytochrome b gene of mitochondrial DNA (mtDNA) from herring gull colonies in the Great Lakes basin and from a site in the Maritimes. A 307-bp fragment of the gene was analyzed using a rapid mutation screening procedure coupling directed termination PCR (DT-PCR) with single-stranded conformation polymorphism (SSCP). Seven mtDNA haplotypes were revealed in 224 specimens with a common haplotype dominating all populations. Direct sequencing of a 1063-bp fragment of the cytochrome b gene identified 8 additional haplotypes, but the sequence divergence among all 15 haplotypes was very low (average 0.24%). These data suggest that herring gulls experienced a bottleneck during the last glaciation that is now reflected in their low levels of genetic divergence. The geographic distribution of mtDNA haplotypes indicates that gene flow among herring gull populations is sufficient to ensure genetic homogeneity in the Great Lakes, but insufficient to homogenize genetic variation between the Great Lakes and the Maritimes. Meanwhile, a comparison analysis of frozen egg specimens suggests a possible shift in the genetic composition of the Great Lakes populations over the last 15 years. JF - Journal of Great Lakes Research AU - Chen, Junjian Z AU - Yauk, CL AU - Hebert, C AU - Hebert, PDN AD - Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA, jjchen@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 199 EP - 209 VL - 27 IS - 2 SN - 0380-1330, 0380-1330 KW - Herring gull KW - North America, Great Lakes KW - mitochondrial DNA KW - ASFA 1: Biological Sciences & Living Resources; Water Resources Abstracts KW - Bioindicators KW - Homogeneity KW - Cytochromes KW - Instrumentation KW - ANW, Canada, Maritime Prov. KW - Genetic isolation KW - Genetic diversity KW - Mitochondria KW - Population genetics KW - Lakes KW - Gulls KW - Larus argentatus KW - DNA KW - Temperate Zone KW - Data Collections KW - SW 5010:Network design KW - Q1 08443:Population genetics KW - SW 0850:Lakes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18077858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Great+Lakes+Research&rft.atitle=Genetic+Variation+in+Mitochondrial+DNA+of+North+American+Herring+Gulls%2C+Larus+argentatus&rft.au=Chen%2C+Junjian+Z%3BYauk%2C+CL%3BHebert%2C+C%3BHebert%2C+PDN&rft.aulast=Chen&rft.aufirst=Junjian&rft.date=2001-01-01&rft.volume=27&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Journal+of+Great+Lakes+Research&rft.issn=03801330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Cytochromes; Population genetics; Genetic isolation; DNA; Mitochondria; Genetic diversity; Homogeneity; Bioindicators; Lakes; Instrumentation; Gulls; Temperate Zone; Data Collections; Larus argentatus; ANW, Canada, Maritime Prov. ER - TY - JOUR T1 - Potential Estrogenic Effects of Bisphenol-A Estimated by in Vitro and in Vivo Combination Assays AN - 18033426; 5995756 AB - The potential estrogenic activities of bisphenol-A were investigated in vitro (E-screen and estrogen receptor competitive binding bioassays) and in vivo (uterotrophic assay). Uterotrophic responses were evaluated using mature ovariectomized Sprague-Dawley female rats treated subcutaneously with bisphenol A (1, 5, 10, 50, and 100 mg/kg/day), E2 (0.3 mu g/kg), and DES (0.3 mu g/kg) for 3 consecutive days. In a MCF-7 cell proliferation assay, E2 and DES used as positive estrogens induced maximum proliferation of MCF-7 cells at 1.0 nM, whereas BPA slightly induced MCF-7 cell proliferation at a higher level of 0.1 mu M and maximum proliferation at 10 mu M. In a competitive binding assay, E2 and DES showed inhibition of 17 beta -[ sub(3)H]estradiol binding to the rat uterus ER with an IC sub(50) of 1.0 nM and 0.5 nM, respectively. However, BPA had an IC sub(50) of 5 mu M, which was approximately 5, 000 or 10, 000-fold greater than the IC sub(50) of E2 and DES. In uterotrophic assays, uterus (wet and blotted) and vagina weights were significantly increased at the dose of BPA 100 mg/kg/day in OVX Sprague-Dawley rats. These studies demonstrate that BPA exhibits weak estrogenic activity in all experimental systems, and thus its migration from epoxy resins or polycarbonate products should be controlled not to exceed a safety levels for humans. JF - Journal of Toxicological Sciences AU - Kim, Hyung Sik AU - Han, Soon-Young AU - Yoo, Sun Dong AU - Lee, Byung Mu AU - Park, Kui Lea AD - Reproductive & Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 111 EP - 118 PB - Japanese Society of Toxicology VL - 26 IS - 3 SN - 0388-1350, 0388-1350 KW - in vitro KW - in vivo KW - rats KW - Toxicology Abstracts KW - JOI: JST. JSTAGE/jts/26.111 KW - Bisphenol-A KW - E-screen KW - Competitive binding assay KW - Uterotrophic assay KW - Bisphenol A KW - Bioassays KW - Cell proliferation KW - estrogenic activity KW - polycarbonate KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18033426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicological+Sciences&rft.atitle=Potential+Estrogenic+Effects+of+Bisphenol-A+Estimated+by+in+Vitro+and+in+Vivo+Combination+Assays&rft.au=Kim%2C+Hyung+Sik%3BHan%2C+Soon-Young%3BYoo%2C+Sun+Dong%3BLee%2C+Byung+Mu%3BPark%2C+Kui+Lea&rft.aulast=Kim&rft.aufirst=Hyung&rft.date=2001-01-01&rft.volume=26&rft.issue=3&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicological+Sciences&rft.issn=03881350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Bioassays; Cell proliferation; estrogenic activity; polycarbonate ER - TY - JOUR T1 - Cardiovascular Effects of Buccal Exposure to Dermal Nicotine Patches in the Dog: A Comparative Evaluation AN - 17908168; 5164723 AB - Objective: Safety concerns have been raised over the possible effects of inappropriate exposure to transdermal nicotine patches. This study was initiated to determine whether placement of these products into the mouth could affect cardiovascular function. Methods: In a series of 10 anesthetized beagle dogs, Nicoderm registered , Habitrol registered , ProStep registered I (Intact), ProStep registered D (Damaged) transdermal nicotine products or the Skoal Bandit registered smokeless tobacco plug were placed in the buccal cavity for 5 minutes. Systemic arterial blood pressure and the electrocardiogram were monitored for up to 90 minutes after exposure with blood samples at intervals during the first 10 minutes for plasma nicotine concentration. Results: The systolic and diastolic arterial blood pressures and heart rate increased within 2 minutes of buccal exposure to either the intact or the damaged ProStep nicotine product. Ventricular arrhythmias were observed in 6 of 10 dogs exposed to the intact patch and 7 of 10 dogs exposed to the damaged patch during the period of maximal cardiovascular response. Modest increases in systemic blood pressure and heart rate were seen with the Nicoderm and Habitrol products but not with the Skoal Bandit. The increases in systemic arterial pressure and heart rate occurring after exposure to ProStep were significantly more severe than those observed after Nicoderm and Habitrol. Mean peak nicotine levels of 9.8 mu g/mL (ProStep I), 5.4 mu g/mL (ProStep D), 3.4 mu g/mL (Habitrol), 2.5 mu g/mL (Nicoderm), and 0.12 mu g/mL (Skoal Bandit) were detected within 2 to 10 minutes after buccal placement of the product. Conclusions: Certain transdermal nicotine patches, when applied to a nondermal site such as the buccal cavity for a short period (5 minutes) can rapidly provoke significant cardiovascular alterations (hypertension, tachycardia, and ventricular arrhythmias). The magnitude of the cardiovascular responses occurring after buccal exposure to a product such as ProStep could pose a risk to susceptible individuals. JF - Journal of Toxicology: Clinical Toxicology AU - Herman, E H AU - Vick, JA AU - Strong, J M AU - Parker, R J AU - Geyer, HM III AU - Kramer, ED AU - Higgins, K M AU - Sistare, F D AD - Division of Applied Pharmacology Research, Office of Testing and Research, Center for Drug Evaluation and Research, 8301 Muirkirk Road, Laurel, MD, 20708, USA, hermaneh@cder.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 135 EP - 142 VL - 39 IS - 2 SN - 0731-3810, 0731-3810 KW - dermal nicotine patches KW - dogs KW - Toxicology Abstracts KW - Cardiovascular system KW - Skin KW - Nicotine KW - Oral cavity KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17908168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology%3A+Clinical+Toxicology&rft.atitle=Cardiovascular+Effects+of+Buccal+Exposure+to+Dermal+Nicotine+Patches+in+the+Dog%3A+A+Comparative+Evaluation&rft.au=Herman%2C+E+H%3BVick%2C+JA%3BStrong%2C+J+M%3BParker%2C+R+J%3BGeyer%2C+HM+III%3BKramer%2C+ED%3BHiggins%2C+K+M%3BSistare%2C+F+D&rft.aulast=Herman&rft.aufirst=E&rft.date=2001-01-01&rft.volume=39&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology%3A+Clinical+Toxicology&rft.issn=07313810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Nicotine; Oral cavity; Cardiovascular system ER - TY - JOUR T1 - Developmental Toxicity Interactions of Methanol and Radiofrequency Radiation or 2-Methoxyethanol in Rats AN - 17907731; 5164760 AB - This research was undertaken to determine potential interactions among chemical and physical agents. Radiofrequency (RF) radiation is used in numerous workplaces, and many workers are concurrently exposed to RF radiation and various chemicals. The developmental toxicity of RF radiation is associated with the degree and duration of hyperthermia induced by the exposure. Previous animal research indicates that hyperthermia induced by an elevation in ambient temperature can potentiate the toxicity and teratogenicity of some chemical agents. We previously demonstrated that combined exposure to RF radiation (10 MHz) and the industrial solvent, 2-methoxyethanol (2ME), enhanced teratogenicity in rats. Interactions were noted at even the lowest levels of 2ME tested, but only at hyperthermic levels of RF radiation. The purpose of the present research is to investigate if the interactive effects noted for RF radiation and 2ME are unique to these agents, or if similar interactions might be seen with other chemicals. Because methanol is widely used as a solvent as well as fuel additive, and, at high levels, is teratogenic in animals, we selected methanol as a chemical to address generalizability. Based on the literature and our pilot studies, 0, 2, or 3 g/kg methanol (twice, at 6-hour intervals) were administered on gestation day 9 or 13 to groups of 10 Sprague-Dawley rats. Dams treated on day 9 were given methanol and exposed to RF radiation sufficient to maintain colonic temperature at 41 degree C for 60 minutes (or sham). Those treated on day 13 were given methanol plus either 0 or 100 mg/kg 2ME. Because we observed that methanol produced hypothermia, some groups were given the initial dose of methanol concurrently with the RF or 2ME, and others were given the first dose of methanol 1.5 hours prior to RF or 2ME. Dams were sacrificed on gestation day 20, and the fetuses were examined for external malformations. The results indicate that RF radiation or methanol on day 9 increased the incidence of resorbed fetuses, but no interactive effects were observed. The resorptions were highest in groups given the experimental treatments 1.5 hours apart. The higher dose of methanol also reduced fetal weights. Administration of 2ME or methanol on day 13 increased the rate of malformations, and there was evidence of a positive interaction between 2ME and methanol. Fetal weights were reduced by 2ME and methanol alone, but no interaction was observed. Also, separation of the dosing with the teratogens did not affect the results. These results point out that interactions in developmental toxicology, such as those of RF radiation, 2ME, and methanol that we have studied, are complex, and such interactions cannot be fully understood or predicted without more research. It is important that combined exposure effects be considered when developing both physical agent and chemical agent exposure guidelines and intervention strategies. JF - International Journal of Toxicology AU - Nelson, B K AU - Snyder, D L AU - Shaw, P B AD - NIOSH C-24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, bknelson@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 89 EP - 100 VL - 20 IS - 2 SN - 1091-5818, 1091-5818 KW - rats KW - 2-methoxyethanol KW - methyl cellosolve KW - Toxicology Abstracts KW - Electromagnetic radiation KW - Radiation KW - Methanol KW - Teratogenicity KW - X 24210:Radiation & radioactive materials KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17907731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Toxicology&rft.atitle=Developmental+Toxicity+Interactions+of+Methanol+and+Radiofrequency+Radiation+or+2-Methoxyethanol+in+Rats&rft.au=Nelson%2C+B+K%3BSnyder%2C+D+L%3BShaw%2C+P+B&rft.aulast=Nelson&rft.aufirst=B&rft.date=2001-01-01&rft.volume=20&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Radiation; Methanol; Electromagnetic radiation; Teratogenicity ER - TY - JOUR T1 - Nonfatal occupational injuries among African American women by industrial group AN - 17901407; 5142823 AB - This study examined characteristics of nonfatal work-related injuries treated in emergency departments (EDs) among African American women by industry in the U.S. in 1996. Injury data were from the National Electronic Injury Surveillance System (NEISS). Employment data were from the Current Population Survey (CPS). In 1996, African American women, age 16 or older, were treated in EDs for an estimated 158,335 nonfatal work-related injuries (2.6/100 full-time equivalents, FTEs). Of these injuries, 39% occurred in healthcare, 14% in retail trade, and 12% in manufacturing. Healthcare experienced the highest injury rate of 5.1/100 FTEs, followed by a rate of 2.6/100 FTEs in retail trade. This study is the first report on work-related injuries treated in EDs among African American women by industry on a national level. Injury patterns varied by industry in terms of source, event, diagnoses, and body part. For example, in healthcare the leading source involved interactions with patients and the leading event was physical exertion; whereas in retail trade the leading source was structures and surfaces, and the leading event was contact with objects. These findings demonstrate that nonfatal work-related injuries are often concentrated in certain high-risk industries, such as healthcare, manufacturing, and retail trade. To improve occupational safety and health for African American women, future research activities and prevention strategies should address the high-risk industries identified in this analysis. JF - Journal of Safety Research AU - Chen, Guang-Xiang AU - Hendricks, K J AD - NIOSH/DSR, 1095 Willowdale Road, Morgantown, WV 26505, USA, gdc0@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 75 EP - 84 VL - 32 IS - 1 SN - 0022-4375, 0022-4375 KW - African Americans KW - emergency medical services KW - Health & Safety Science Abstracts KW - Accidents KW - Injuries KW - Occupational safety KW - Females KW - Ethnic groups KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17901407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Nonfatal+occupational+injuries+among+African+American+women+by+industrial+group&rft.au=Chen%2C+Guang-Xiang%3BHendricks%2C+K+J&rft.aulast=Chen&rft.aufirst=Guang-Xiang&rft.date=2001-01-01&rft.volume=32&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ethnic groups; Females; Accidents; Injuries; Occupational safety ER - TY - JOUR T1 - Gene- and Tissue-Specificity of Mutation in Big Blue super( registered ) Rats Treated With the Hepatocarcinogen N-Hydroxy-2-acetylaminofluorene AN - 17887480; 5126033 AB - In a previous study, we found that treating transgenic Big Blue super( registered ) rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cells, induced lacl mutants in the liver, and induced much lower frequencies of lacl and hprt mutants in spleen lymphocytes. In the present study, sequence analysis was conducted on lacl DNA and hprt cDNA from the mutants, to determine the mutational specificity of N-OH-AAF in the rat. All the mutation spectra from N-OH-AAF-treated rats differed significantly from corresponding mutation profiles from untreated animals (P = 0.02 to P < 0.0001). Although there were similarities among the mutational patterns derived from N-OH-AAF-treated rats (e.g., G:C arrow right T:A transversion was the most common mutation in all mutation sets), there were significant differences in the patterns of basepair substitution and frameshift mutation between the liver and spleen lymphocyte lacl mutants (P = 0.02) and between the spleen lymphocyte lacl and hprt mutants (P = 0.04). Also, multiplex PCR analysis of genomic DNA from the hprt mutants indicated that 12% of mutants from treated rats had major deletions in the hprt gene; no corresponding incidence of large deletions was evident among lacl mutations. All the mutation profiles reflect the general mutational specificity of the major DNA adduct formed by N-OH-AAF. The differences between N-OH-AAF mutation in the endogenous gene and transgene can be partially explained by the structures of the two genes. The tissue-specificity of the mutation spectra may contribute to targeting tumor formation to the liver. JF - Environmental and Molecular Mutagenesis AU - Chen, T AU - Mittelstaedt, R A AU - Shelton, S D AU - Dass, S B AU - Manjanatha, M G AU - Casciano, DA AU - Heflich, R H AD - National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, HFT-120, 3900 NCTR Road, Jefferson, AR 72079, USA, TChen@NCTR.FDA.GOV Y1 - 2001 PY - 2001 DA - 2001 SP - 203 EP - 214 VL - 37 IS - 3 SN - 0893-6692, 0893-6692 KW - N-Hydroxy-2-acetylaminofluorene KW - hprt gene KW - lacl gene KW - Toxicology Abstracts KW - Transgenic animals KW - DNA adducts KW - Mutagenicity KW - Tumorigenesis KW - Liver KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17887480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Gene-+and+Tissue-Specificity+of+Mutation+in+Big+Blue+super%28+registered+%29+Rats+Treated+With+the+Hepatocarcinogen+N-Hydroxy-2-acetylaminofluorene&rft.au=Chen%2C+T%3BMittelstaedt%2C+R+A%3BShelton%2C+S+D%3BDass%2C+S+B%3BManjanatha%2C+M+G%3BCasciano%2C+DA%3BHeflich%2C+R+H&rft.aulast=Chen&rft.aufirst=T&rft.date=2001-01-01&rft.volume=37&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mutagenicity; DNA adducts; Transgenic animals; Liver; Tumorigenesis ER - TY - JOUR T1 - Comparison of hprt and lacl Mutant Frequency With DNA Adduct Formation in N-Hydroxy-2-acetylaminofluorene-Treated Big Blue super( registered ) Rats AN - 17887443; 5126032 AB - N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) is the proximate carcinogenic metabolite of the powerful rat liver carcinogen 2-acetylaminofluorene. In this study, transgenic Big Blue super( registered ) rats were used to examine the relationship between in vivo mutagenicity and DNA adduct formation by N-OH-AAF in the target liver compared with that in nontarget tissues. Male rats were given one, two, or four doses of 25 mg N-OH-AAF/kg body weight by i.p. injection at 4-day intervals, and groups of treated and control rats were euthanized up to 10 weeks after beginning the dosing. Mutant frequencies were measured in the spleen lymphocyte hprt gene, and lacl mutant frequencies were determined in the liver and spleen lymphocytes. At 6 weeks after beginning the dosing, the hprt mutant frequency in spleen lymphocytes from the four-dose group was 16.5 x 10 super(-6) compared with 3.2 x 10 super(-6) in control animals. Also at 6 weeks, rats given one, two, or four doses of N-OH-AAF had lacl mutant frequencies in the liver of 97.6, 155.6, and 406.8 x 10 super(-6), respectively, compared with a control frequency of 25.7 x 10 super(-6); rats given four doses had lacl mutant frequencies in spleen lymphocytes of 55.8 x 10 super(-6) compared with a control frequency of 20.4 x 10 super(-6). Additional rats were evaluated for DNA adduct formation in the liver, spleen lymphocytes, and bone marrow by super(32)P-postlabeling. Adduct analysis was conducted 1 day after one, two, and four treatments with N-OH-AAF, 5 days after one treatment, and 9 days after two treatments. N-(Deoxyguanosin-8-yl)-2-aminofluorene was the major DNA adduct identified in all the tissues examined. Adduct concentrations increased with total dose to maximum values in samples taken 1 day after two doses, and remained essentially the same after four doses. In samples taken after four doses, adduct levels were 103, 28, and 7 fmol/ mu g of DNA in liver, spleen lymphocytes, and bone marrow, respectively. The results indicate that the extent of both DNA adduct formation and mutant induction correlates with the organ specificity for N-OH-AAF carcinogenesis in the rat. JF - Environmental and Molecular Mutagenesis AU - Chen, T AU - Mittelstaedt, R A AU - Aidoo, A AU - Hamilton, L P AU - Beland, F A AU - Casciano, DA AU - Heflich, R H AD - National Center for Toxicological Research, HFT-120, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA, TChen@NCTR.FDA.GOV Y1 - 2001 PY - 2001 DA - 2001 SP - 195 EP - 202 VL - 37 IS - 3 SN - 0893-6692, 0893-6692 KW - rats KW - N-Hydroxy-2-acetylaminofluorene KW - hprt gene KW - lacl gene KW - Genetics Abstracts; Toxicology Abstracts KW - Transgenic animals KW - DNA damage KW - DNA adducts KW - Mutagenicity KW - Carcinogenesis KW - Liver KW - Spleen KW - Lymphocytes KW - Mutagenesis KW - X 24155:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17887443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Comparison+of+hprt+and+lacl+Mutant+Frequency+With+DNA+Adduct+Formation+in+N-Hydroxy-2-acetylaminofluorene-Treated+Big+Blue+super%28+registered+%29+Rats&rft.au=Chen%2C+T%3BMittelstaedt%2C+R+A%3BAidoo%2C+A%3BHamilton%2C+L+P%3BBeland%2C+F+A%3BCasciano%2C+DA%3BHeflich%2C+R+H&rft.aulast=Chen&rft.aufirst=T&rft.date=2001-01-01&rft.volume=37&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mutagenesis; DNA adducts; Carcinogenesis; DNA damage; Mutagenicity; Transgenic animals; Liver; Spleen; Lymphocytes ER - TY - JOUR T1 - Detection of microbial antigens in metal working fluids AN - 17875494; 5121840 AB - In recent years there have been several reports of hypersensitivity pneumonitis (HP) or an HP-like illness occurring among machinists working with water-based metal working fluids (MWF). Microbial contamination of the MWF is common and microbial agents have been suspected to be causal agents for the HP-like illness, but no specific etiologic agent has been identified to date. In particular, gram negative bacteria and biocide resistant mycobacterial species may colonize the MWF, and may stimulate an inflammatory response if inhaled. Because direct culture techniques provide data only about viable organisms present at the time the sample was collected, we have been evaluating techniques to detect microbial substances (antigens) that may be present and persist in the MWF. We have found that the endotoxin of gram negative bacteria can be detected in MWF using the limulus amoebocyte lysate (LAL) assay, and may be present in high concentrations. In addition, MWF samples have been analyzed by Western Blot techniques using polyclonal antibodies to mycobacteria to demonstrate the presence of mycobacterial antigens in these samples. The use of non-culture-based techniques for the assessment of microbial contamination of MWF may help to determine the role of microorganisms in the etiology of HP associated with MWF exposure. JF - International Biodeterioration & Biodegradation AU - Lewis, D M AU - Janotka, E AU - Whitmer, M P AU - Bledsoe, T A AD - Analytical Services Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, dml1@cdc.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 89 EP - 94 VL - 47 IS - 2 SN - 0964-8305, 0964-8305 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Endotoxins KW - Western blotting KW - Antigens KW - Mycobacterium KW - Gram-negative bacteria KW - Polyclonal antibodies KW - Metal-working fluids KW - A 01116:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17875494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Biodeterioration+%26+Biodegradation&rft.atitle=Detection+of+microbial+antigens+in+metal+working+fluids&rft.au=Lewis%2C+D+M%3BJanotka%2C+E%3BWhitmer%2C+M+P%3BBledsoe%2C+T+A&rft.aulast=Lewis&rft.aufirst=D&rft.date=2001-01-01&rft.volume=47&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=International+Biodeterioration+%26+Biodegradation&rft.issn=09648305&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Special Issue: Biodeterioration Problems of Industrial Concern, Part I. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium; Antigens; Metal-working fluids; Endotoxins; Gram-negative bacteria; Western blotting; Polyclonal antibodies ER - TY - JOUR T1 - Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: Criteria, validation, strategies AN - 17874506; 5121753 AB - In the future, biomarkers will play an increasingly important role in all phases of drug development, including regulatory review. However, only a few of these biomarkers will become established well enough to serve in regulatory decision making as surrogate endpoints, thereby substituting for traditional clinical endpoints. Even generally accepted surrogate endpoints are unlikely to capture all the therapeutic benefits and potential adverse effects a drug will have in a diverse patient population. Accordingly, combinations of biomarkers probably will be needed to provide a more complete characterization of the spectrum of pharmacologic response. In the future, pharmacogenomic approaches, including those based on differential expression of gene arrays, will provide panels of relevant biomarkers that can be expected to transform the drug development process. JF - Annual Review of Pharmacology and Toxicology AU - Lesko, L J AU - Atkinson, AJ Jr AD - Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA, LeskoL@cder.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 347 EP - 366 VL - 41 SN - 0362-1642, 0362-1642 KW - biomarkers KW - Toxicology Abstracts KW - Safety regulations KW - Reviews KW - Government policy KW - Pharmaceuticals KW - Drugs KW - X 24230:Legislation & recommended standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17874506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Pharmacology+and+Toxicology&rft.atitle=Use+of+biomarkers+and+surrogate+endpoints+in+drug+development+and+regulatory+decision+making%3A+Criteria%2C+validation%2C+strategies&rft.au=Lesko%2C+L+J%3BAtkinson%2C+AJ+Jr&rft.aulast=Lesko&rft.aufirst=L&rft.date=2001-01-01&rft.volume=41&rft.issue=&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Pharmacology+and+Toxicology&rft.issn=03621642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pharmaceuticals; Government policy; Reviews; Drugs; Safety regulations ER - TY - JOUR T1 - Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats AN - 17873521; 5119366 AB - Genistein, the principal soy isoflavone, has estrogenic activity and is widely consumed by humans for putative beneficial health effects. The goal of the present study was to measure placental transfer of genistein in rats as a possible route of developmental exposure. Pregnant Sprague-Dawley rats were administered genistein orally, either by diet or by gavage. Concentrations of genistein aglycone and conjugates were measured in maternal and offspring serum and brain using HPLC with isotope dilution electrospray tandem mass spectrometry. Although fetal or neonatal serum concentrations of total genistein were approximately 20-fold lower than maternal serum concentrations, the biologically active genistein aglycone concentration was only 5-fold lower. Fetal brain contained predominately genistein aglycone at levels similar to those in the maternal brain. These studies show that genistein aglycone crosses the rat placenta and can reach fetal brain from maternal serum genistein levels that are relevant to those observed in humans. JF - Reproductive Toxicology AU - Doerge AU - Churchwell, MI AU - Chang, H C AU - Newbold, R R AU - Delclos, K B AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, ddoerge@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 105 EP - 110 VL - 15 IS - 2 SN - 0890-6238, 0890-6238 KW - rats KW - Toxicology Abstracts KW - Prenatal experience KW - Placental transfer KW - Isoflavone KW - Genistein KW - Soybeans KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17873521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Placental+transfer+of+the+soy+isoflavone+genistein+following+dietary+and+gavage+administration+to+Sprague+Dawley+rats&rft.au=Doerge%3BChurchwell%2C+MI%3BChang%2C+H+C%3BNewbold%2C+R+R%3BDelclos%2C+K+B&rft.aulast=Doerge&rft.aufirst=&rft.date=2001-01-01&rft.volume=15&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Isoflavone; Soybeans; Placental transfer; Genistein; Prenatal experience ER - TY - JOUR T1 - Determination of Capsaicin and Dihydrocapsaicin in Air in a Pickle and Pepper Processing Plant AN - 17871248; 5108471 AB - A sampling and analytical method has been developed for measurement of capsaicin and dihydrocapsaicin in air. This method is applicable to measurement of the capsaicinoids in air in pepper processing plants and involves air sampling with a 13-mm glass fiber filter, recovery of the sample with 2 mL of acetonitrile, filtration of the solution, and analysis by high performance liquid chromatography with fluorescence detection. Excitation and emission wavelengths of the detector were 281 and 312 nm, respectively. Average recoveries were 98 to 104% after fortification of glass fiber filters with 0.13- to 2.9- mu g quantities of capsaicin. Average recoveries of dihydrocapsaicin were 93 to 99% after fortification of glass fiber filters with 0.11- to 3.0- mu g quantities. Detection limits of capsaicin and dihydrocapsaicin were 0.015 and 0.02 mu g per sample, respectively. This method was used successfully for determining air concentrations of capsaicin and dihydrocapsaicin in a health hazard evaluation at a large pickle and pepper processing plant. An interesting phenomenon was the fact that the ratio of capsaicin to dihydrocapsaicin in each of the largest air samples was in the range of 0.3:1 to 0.5:1. Generally, capsaicin is the capsaicinoid that occurs in Capsicum fruit in the greatest relative abundance. JF - American Industrial Hygiene Association Journal AU - Tucker, S P AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Chemical Exposure and Monitoring Branch, 4676 Columbia Parkway, Cincinnati, OH 45226, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 45 EP - 48 VL - 62 IS - 1 SN - 0002-8894, 0002-8894 KW - capsaicin KW - dihydrocapsaicin KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Food processing industry KW - Air sampling KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17871248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Determination+of+Capsaicin+and+Dihydrocapsaicin+in+Air+in+a+Pickle+and+Pepper+Processing+Plant&rft.au=Tucker%2C+S+P&rft.aulast=Tucker&rft.aufirst=S&rft.date=2001-01-01&rft.volume=62&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Air sampling; Occupational exposure; Food processing industry ER - TY - JOUR T1 - Respiratory Protection as a Function of Respirator Fitting Characteristics and Fit-Test Accuracy AN - 17871204; 5108470 AB - The fitting characteristics of particulate respirators are no longer assessed in the National Institute for Occupational Safety and Health respirator certification program. It is important for respirator program administrators to understand the implications of that change and the additional burden it may impose. To address that issue, a typical respirator fit-testing program is analyzed using a mathematical model that describes the effectiveness of a fit-testing program as a function of the fitting characteristics of the respirator and the accuracy of the fit-testing method. The model is used to estimate (1) the respirator assignment error, the percentage of respirator wearers mistakenly assigned an ill-fitting respirator; (2) the number of fit-test trials necessary to qualify a group of workers for respirator use; and (3) the number of workers who will fail the fit-test with any candidate respirator model and thereby fail to qualify for respirator use. Using data from previous studies, the model predicts respirator assignment errors ranging from 0 to 20%, depending on the fitting characteristics of the respirator models selected and the fit-testing method used. This analysis indicates that when respirators do not necessarily have good fitting characteristics, respirator program administrators should exercise increased care in the selection of respirator models and increased care in fit-testing. Also presented are ways to assess the fitting characteristics of candidate respirator models by monitoring the first-time fit-testing results. The model demonstrates that significant public health and economic benefits can result when only respirators having good fitting characteristics are purchased and respirators are assigned to workers using highly accurate fit-testing methods. JF - American Industrial Hygiene Association Journal AU - Campbell, D L AU - Coffey, C C AU - Lenhart, S W AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 36 EP - 44 VL - 62 IS - 1 SN - 0002-8894, 0002-8894 KW - fit testing KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Particulates KW - Protective equipment KW - Respirators KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17871204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Respiratory+Protection+as+a+Function+of+Respirator+Fitting+Characteristics+and+Fit-Test+Accuracy&rft.au=Campbell%2C+D+L%3BCoffey%2C+C+C%3BLenhart%2C+S+W&rft.aulast=Campbell&rft.aufirst=D&rft.date=2001-01-01&rft.volume=62&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Protective equipment; Respirators; Particulates; Inhalation ER - TY - JOUR T1 - Genetic analysis for virulence factors in Escherichia coli O104:H21 that was implicated in an outbreak of hemorrhagic colitis AN - 17855321; 4884417 AB - Isolates of enterohemorrhagic Escherichia coli (EHEC) of serotype O104:H21 implicated in a 1994 outbreak of hemorrhagic colitis in Montana were analyzed for the presence of trait EHEC virulence markers. By using a multiplex PCR that specifically amplifies several genes, the O104:H21 strains were found to carry only the Shiga toxin 2 gene (stx2) and to express Stx2. They did not have the eaeA gene for gamma -intimin, which is typically found in O157:H7, or the alpha - or beta -intimin derivatives, which are common in other EHEC and enteropathogenic E. coli serotypes. Results of the multiplex PCR also indicated that the ehxA gene for enterohemolysin was absent from O104:H21. This, however, was not consistent with the results of a phenotypic assay that showed them to be hemolytic or a PCR analysis with another set of ehxA-specific primers, which indicated the presence of ehxA. To resolve this discrepancy, the ehxA region in O104:H21 and O157:H7 strains, to which the multiplex PCR primers anneal, was cloned and sequenced. Comparison of the sequences showed that the upstream primer binding site in the ehxA gene of O104:H21 was not identical to that of O157:H7. Specifically, there were several base mutations, including an A-to-G substitution at the 3' end of the primer binding site. These base mutations are presumably not unique to O104:H21, since other enterohemolytic serotypes were also not detected with the ehxA primers used in the multiplex PCR. Comparison of the ehxA sequences of O104:H21 strains with those of other Stx-producing E. coli strains showed that they more closely resembled those of O8:H19 strains, which have cluster II ehxA genes, than those of O157:H7 strains, which have cluster I ehxA sequences. By modifying the upstream ehxA primer, the multiplex PCR was able to detect ehxA genes in both O157:H7 and O104:H21 strains. JF - Journal of Clinical Microbiology AU - Feng, P AU - Weagant, S D AU - Monday AD - HFS-516, FDA, 200 C St. SW, Washington, DC 20204, USA, pfeng@cfsan.fda.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 24 EP - 28 VL - 39 IS - 1 SN - 0095-1137, 0095-1137 KW - ehxA gene KW - stx2 gene KW - Microbiology Abstracts B: Bacteriology KW - Genotyping KW - Escherichia coli KW - Polymerase chain reaction KW - Mutation KW - Colitis KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17855321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Genetic+analysis+for+virulence+factors+in+Escherichia+coli+O104%3AH21+that+was+implicated+in+an+outbreak+of+hemorrhagic+colitis&rft.au=Feng%2C+P%3BWeagant%2C+S+D%3BMonday&rft.aulast=Feng&rft.aufirst=P&rft.date=2001-01-01&rft.volume=39&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Colitis; Polymerase chain reaction; Genotyping; Mutation ER - TY - JOUR T1 - Neonatal dexamethasone on Day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits AN - 17852319; 5104977 AB - Developmental glucocorticoid treatment in rats has been shown to cause body and brain weight decrements concurrent with behavioral alterations. Here, Sprague-Dawley rats were treated with the synthetic glucocorticoid, dexamethasone (DEX), on postnatal day (PND) 7 (1.5 mg/kg, sc, injected in the morning and afternoon). Behavioral assessments of negative geotaxis, locomotor activity (open field, maze exploration, residential running wheel, residential figure 8 maze), open-field activity response to amphetamine, acoustic startle, prepulse inhibition (PPI) of acoustic startle, juvenile play behavior, anxiety (emergence tests), motor coordination (rotarod performance), spatial learning (Morris water maze and food-reinforced complex maze), and operant performance (time estimation and response inhibition) were assessed in male rats. Body weight was decreased beginning at PND 43 until sacrifice on PND 127. Whole and regional brain weights were less, especially hippocampus, cerebellum, brainstem, and cortical remnant. Indications of delayed development were apparent; specifically, DEX-treated rats took significantly longer to turn on PND 8, but not PND 9, in the negative geotaxis test. DEX treatment induced deficits in the Morris water maze that were similar to hippocampal deficits. Open-field activity changes were inconsistent; however, DEX-treated rats were hyperactive during the dark period in running wheel tests. There were no indications of changes in reactivity or emotionality. JF - Neurotoxicology and Teratology AU - Ferguson, SA AU - Paule, M G AU - Holson, R R AD - HFT-132, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 57 EP - 69 VL - 23 IS - 1 SN - 0892-0362, 0892-0362 KW - rats KW - development KW - Toxicology Abstracts KW - Dexamethasone KW - Behavior KW - Hippocampus KW - Brain KW - Neonates KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17852319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Neonatal+dexamethasone+on+Day+7+in+rats+causes+behavioral+alterations+reflective+of+hippocampal%2C+but+not+cerebellar%2C+deficits&rft.au=Ferguson%2C+SA%3BPaule%2C+M+G%3BHolson%2C+R+R&rft.aulast=Ferguson&rft.aufirst=SA&rft.date=2001-01-01&rft.volume=23&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Hippocampus; Brain; Behavior; Neonates ER - TY - JOUR T1 - Crystalline silica exposure and lung cancer mortality in diatomaceous earth industry workers: a quantitative risk assessment AN - 17843179; 4876563 AB - Objective--To use various exposure-response models to estimate the risk of mortality from lung cancer due to occupational exposure to respirable crystalline silica dust. Methods--Data from a cohort mortality study of 2342 white male California diatomaceous earth mining and processing workers exposed to crystalline silica dust (mainly cristobalite) were reanalyzed with Poisson regression and Cox's proportional hazards models. Internal and external adjustments were used to control for potential confounding from the effects of time since first observation, calendar time, age, and Hispanic ethnicity. Cubic smoothing spline models were used to assess the fit of the models. Exposures were lagged by 10 years. Evaluations of the fit of the models were performed by comparing their deviances. Lifetime risks of lung cancer were estimated up to age 85 with an actuarial approach that accounted for competing causes of death. Conclusions--There was a significant risk of mortality from lung cancer that increased with cumulative exposure to respirable crystalline silica dust. The predicted number of deaths from lung cancer suggests that current occupational health standards may not be adequately protecting workers from the risk of lung cancer. JF - Occupational and Environmental Medicine AU - Rice, F L AU - Park, R AU - Stayner, L AU - Smith, R AU - Gilbert, S AU - Checkoway, H AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226-1998, USA, frice@cdc.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 38 EP - 45 VL - 58 IS - 1 SN - 1351-0711, 1351-0711 KW - man KW - silicon dioxide KW - USA, California KW - cristobalite KW - diatomaceous earth KW - silica KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Risk assessment KW - Dust KW - Regression analysis KW - Industrial pollution KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Mines KW - Cancer KW - Silica KW - Lung KW - Mining KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24162:Chronic exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17843179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Crystalline+silica+exposure+and+lung+cancer+mortality+in+diatomaceous+earth+industry+workers%3A+a+quantitative+risk+assessment&rft.au=Rice%2C+F+L%3BPark%2C+R%3BStayner%2C+L%3BSmith%2C+R%3BGilbert%2C+S%3BCheckoway%2C+H&rft.aulast=Rice&rft.aufirst=F&rft.date=2001-01-01&rft.volume=58&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mining; Risk assessment; Occupational exposure; Lung cancer; Dust; Mortality; Silica; Lung; Cancer; Mines; Industrial pollution; Regression analysis ER - TY - JOUR T1 - Genetic and Biochemical Analyses of BvgA Interaction with the Secondary Binding Region of the fha Promoter of Bordetella pertussis AN - 17826384; 4859834 AB - The BvgA-BvgS two-component signal transduction system regulates expression of virulence factors in Bordetella pertussis. The BvgA response regulator activates transcription by binding to target promoters, which include those for the genes encoding filamentous hemagglutinin (fha) and pertussis toxin (ptx). We have previously shown that at both promoters the phosphorylated form of BvgA binds multiple high- and low-affinity sites. Specifically, at the fha promoter, we proposed that there may be high- and a low-affinity binding sites for the BvgA dimer. In our present investigation, we used DNA binding analyses and in vitro and in vivo assays of promoters with substitutions and deletions to support and extend this hypothesis. Our observations indicate that (i) binding of BvgA~P to a primary (high-affinity) site and a secondary binding region (lower affinity) is cooperative, (ii) although both the primary binding site and the secondary binding region are required for full activity of the wild-type (undeleted) promoter, deletion of two helical turns within the secondary binding region can produce a fully active or hyperactive promoter, and (iii) BvgA binding to the secondary binding region shows limited DNA sequence specificity. JF - Journal of Bacteriology AU - Boucher, P E AU - Yang, M AU - Schmidt, D M AU - Stibitz, S AD - DBPAP, CBER, USFDA, Building 29, Room 526, HFM-440, 8800 Rockville Pike, Bethesda, MD 20892, boucher@cber.fda.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 536 EP - 544 VL - 183 IS - 2 SN - 0021-9193, 0021-9193 KW - BvgA protein KW - BvgS protein KW - fha gene KW - ptx gene KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Promoters KW - Bordetella pertussis KW - Signal transduction KW - J 02740:Genetics and evolution KW - N 14662:Gene regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17826384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genetic+and+Biochemical+Analyses+of+BvgA+Interaction+with+the+Secondary+Binding+Region+of+the+fha+Promoter+of+Bordetella+pertussis&rft.au=Boucher%2C+P+E%3BYang%2C+M%3BSchmidt%2C+D+M%3BStibitz%2C+S&rft.aulast=Boucher&rft.aufirst=P&rft.date=2001-01-01&rft.volume=183&rft.issue=2&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.183.2.536-544.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bordetella pertussis; Virulence; Signal transduction; Promoters DO - http://dx.doi.org/10.1128/JB.183.2.536-544.2001 ER - TY - JOUR T1 - Evaluation of the TOPKAT System for Predicting the Carcinogenicity of Chemicals AN - 17820745; 4858985 AB - The TOPKAT computer-based system for predicting chemical carcinogens was evaluated by determining its ability to predict the carcinogenicity of chemicals tested by the National Toxicology Program. TOPKAT was not effective in identifying potential rodent carcinogens and noncarcinogens in the data set analyzed. The chemicals in the TOPKAT database of known carcinogens and non-carcinogens that the software identifies as most "similar" to unknown chemicals are illustrated using six examples. These "similar" chemicals generally bear no apparent relationship to the chemical of interest with regard to metabolism or potential mechanism of carcinogenicity. JF - Environmental and Molecular Mutagenesis AU - Prival, MJ AD - Food and Drug Administration, Genetic Toxicology Branch (HFS-236), 200 C Street SW, Washington, DC 20204, USA, mprival@cfsan.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 55 EP - 69 VL - 37 IS - 1 SN - 0893-6692, 0893-6692 KW - TOPKAT system KW - Toxicology Abstracts KW - Computers KW - Carcinogenicity testing KW - Xenobiotics KW - Toxicity testing KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17820745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Evaluation+of+the+TOPKAT+System+for+Predicting+the+Carcinogenicity+of+Chemicals&rft.au=Prival%2C+MJ&rft.aulast=Prival&rft.aufirst=MJ&rft.date=2001-01-01&rft.volume=37&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Toxicity testing; Xenobiotics; Carcinogenicity testing; Computers ER - TY - JOUR T1 - The economics of regulatory mandates on the HMO market AN - 17819038; 4853518 AB - Recently proposed HMO regulations have involved mandates of two forms: (1) minimum quality standards, and (2) mandated increases in access to speciality care. I show that piecemeal regulation, which uses only one of either mandate (1) or (2), may decrease welfare for all HMO consumers. Under full regulation using both (1) and (2), if the minimum standard is set too low, say, due to political bargaining, a floor-to-ceiling effect occurs. This involves HMOs setting quality at the minimum standard, even when their quality would be above the standard in an unregulated market. Finally, I show how premiums may either increase or decrease under a mandate. JF - Journal of Health Economics AU - Encinosa, W AD - Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Suite 605, 2101 E Jefferson Street, Rockville, MD 20852, USA, wencinos@ahrq.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 85 EP - 107 VL - 20 IS - 1 SN - 0167-6295, 0167-6295 KW - health maintenance organizations KW - Risk Abstracts KW - Government regulations KW - Health care KW - Economics KW - Standards KW - R2 23070:Economics, organization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17819038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Economics&rft.atitle=The+economics+of+regulatory+mandates+on+the+HMO+market&rft.au=Encinosa%2C+W&rft.aulast=Encinosa&rft.aufirst=W&rft.date=2001-01-01&rft.volume=20&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Economics&rft.issn=01676295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Economics; Health care; Government regulations; Standards ER - TY - JOUR T1 - Immunity and protection against Brucella abortus AN - 17811332; 4853880 AB - Brucella abortus is an intracellular pathogen that causes disease in cattle and in humans. The response against B. abortus involves the whole gamut of the immune system, from innate to adaptive immunity resulting from stimulation of antigen-presenting cells, NK cells, CD4 super(+) and CD8 super(+) T cells, and B cells. JF - Microbes and Infection AU - Golding, B AU - Scott, DE AU - Scharf, O AU - Huang, L-Y AU - Zaitseva, M AU - Lapham, C AU - Eller, N AU - Golding, H AD - Division of Hematology, Office of Blood and Blood Research, Center for Biologics Research and Review, Food and Drug Administration, 1401 Woodmont, Rockville Pike, Rockville, MD 20852, USA, golding@cber.fda.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 43 EP - 48 VL - 3 IS - 1 SN - 1286-4579, 1286-4579 KW - CD4 antigen KW - CD8 antigen KW - Microbiology Abstracts B: Bacteriology KW - Abortion KW - Natural killer cells KW - Lymphocytes T KW - Brucella abortus KW - Immunity KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17811332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Immunity+and+protection+against+Brucella+abortus&rft.au=Golding%2C+B%3BScott%2C+DE%3BScharf%2C+O%3BHuang%2C+L-Y%3BZaitseva%2C+M%3BLapham%2C+C%3BEller%2C+N%3BGolding%2C+H&rft.aulast=Golding&rft.aufirst=B&rft.date=2001-01-01&rft.volume=3&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brucella abortus; Abortion; Immunity; Lymphocytes T; Natural killer cells ER - TY - JOUR T1 - Dose-response of retinoic acid induced stress protein synthesis and teratogenesis in mice AN - 17801046; 4845736 AB - Stress proteins are synthesized in response to a variety of stressors, including several teratogenic agents. However, their role, if any, in the teratogenic process is unknown. We have previously demonstrated that all-trans-retinoic acid administered to pregnant CD-1 mice on gestational day 11 or 13 produced limb defects and cleft palate near term in a dose-responsive manner. This chemical also induced the synthesis of several nuclear stress proteins in embryonic tissues within several hours of dosing. The stress proteins were only observed in tissues that eventually became malformed and not in tissues that appeared normal at term. In the current work, we examined the stress response in embryonic target tissues after several different doses of retinoic acid. The nuclear stress proteins were synthesized in a dose-related manner and at a lower retinoic acid dose than doses producing malformations in the corresponding tissue at birth. Each individual stress protein and the total stress protein response were highly correlated, across dose, with the respective malformations observed at term. JF - Reproductive Toxicology AU - Hansen, D K AU - LaBorde, J B AU - Wall, K S AU - Hinson, W G AU - Pipkin, J L AU - Shaddock, J AU - Lyn-Cook, L AU - Young, J F AD - National Center for Toxicological Research, Division of Genetic & Reproductive Toxicology, 3900 NCTR Road, Jefferson, AR 72079-9502, USA, dhansen@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 31 EP - 41 VL - 15 IS - 1 SN - 0890-6238, 0890-6238 KW - dose-response effects KW - mice KW - stress proteins KW - Toxicology Abstracts KW - Embryogenesis KW - Retinoic acid KW - Teratogenesis KW - X 24117:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17801046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Dose-response+of+retinoic+acid+induced+stress+protein+synthesis+and+teratogenesis+in+mice&rft.au=Hansen%2C+D+K%3BLaBorde%2C+J+B%3BWall%2C+K+S%3BHinson%2C+W+G%3BPipkin%2C+J+L%3BShaddock%2C+J%3BLyn-Cook%2C+L%3BYoung%2C+J+F&rft.aulast=Hansen&rft.aufirst=D&rft.date=2001-01-01&rft.volume=15&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Retinoic acid; Teratogenesis; Embryogenesis ER - TY - JOUR T1 - Antisense modulation of 5,10-methylenetetrahydrofolate reductase expression produces neural tube defects in mouse embryos AN - 17798101; 4845735 AB - The role of folate metabolism in producing neural tube defects (NTDs) in humans in unknown. In the current study, antisense oligodeoxyribonucleotide technology was utilized to disrupt normal expression of the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) in organogenesis-stage mouse embryos. Two different antisense probes were microinjected into the amniotic sac of gestation day (GD) 8 mouse embryos with PBS or scrambled sense oligodeoxyribonucleotides injected into control embryos. Concentration-dependent increases in the frequencies of embryos with NTDs were observed for both antisense sequences. The level of mRNA for MTHFR was decreased in embryos treated with the higher concentration of one antisense sequence, indicating that the sequence is able to decrease gene expression. 5-methyltetrahydrofolate, the product of the MTHFR reaction, was able to decrease the incidence of antisense-induced NTDs, but co-injection with L-methionine did not. These results suggest that reduced expression of MTHFR may play a role in producing NTDs. JF - Reproductive Toxicology AU - Hansen, D K AU - Barbee, SA AU - Grafton, T F AU - Gu, Y AU - Streck, R D AD - Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA, dhansen@nctr.fda.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 21 EP - 29 VL - 15 IS - 1 SN - 0890-6238, 0890-6238 KW - mice KW - 5,10-Methylenetetrahydrofolate reductase KW - Toxicology Abstracts KW - Antisense KW - Organogenesis KW - Embryos KW - Folic acid KW - Neural tube defects KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17798101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Antisense+modulation+of+5%2C10-methylenetetrahydrofolate+reductase+expression+produces+neural+tube+defects+in+mouse+embryos&rft.au=Hansen%2C+D+K%3BBarbee%2C+SA%3BGrafton%2C+T+F%3BGu%2C+Y%3BStreck%2C+R+D&rft.aulast=Hansen&rft.aufirst=D&rft.date=2001-01-01&rft.volume=15&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Embryos; Neural tube defects; Antisense; Organogenesis; Folic acid ER - TY - JOUR T1 - Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity AN - 17754886; 4822443 AB - Previous studies have demonstrated a role for B cells, not associated with antibody production, in protection against lethal secondary infection of mice with Francisella tularensis live vaccine strain (LVS). However, the mechanism by which B cells contribute to this protection is not known. To study the specific role of B cells during secondary LVS infection, we developed an in vitro culture system that mimics many of the same characteristics of in vivo infection. Using this culture system, we showed that B cells do not directly control LVS infection but that control of LVS growth is mediated primarily by LVS-primed T cells. Importantly, B cells were not required for the generation of effective memory T cells since LVS-primed, B-cell-deficient (BKO) mice generated CD4 super(+) and CD8 super(+) T cells that controlled LVS infection similarly to LVS-primed CD4 super(+) and CD8 super(+) T cells from wild-type mice. The control of LVS growth appeared to depend primarily on gamma interferon and nitric oxide and was similar in wild-type and BKO mice. Rather, the inability of BKO mice to survive secondary LVS infection was associated with marked neutrophil influx into the spleen very early after challenge. The neutrophilia was directly associated with B cells, since BKO mice reconstituted with naive B cells prior to a secondary challenge with LVS had decreased bacterial loads and neutrophils in the spleen and survived. JF - Infection and Immunity AU - Bosio, C M AU - Elkins, K L AD - Laboratory of Mycobacteria, DBPAP/CBER/FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA, elkins@cber.fda.gov Y1 - 2001/01// PY - 2001 DA - Jan 2001 SP - 194 EP - 203 VL - 69 IS - 1 SN - 0019-9567, 0019-9567 KW - immunology KW - mice KW - animal models KW - CD4 antigen KW - Francisella tularensis KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Tularemia KW - Immune response (cell-mediated) KW - ^g-Interferon KW - Lymphocytes B KW - Lymphocytes T KW - Nitric oxide KW - Vaccines KW - Neutrophilia KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization KW - F 06749:Function KW - F 06756:Function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17754886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Susceptibility+to+secondary+Francisella+tularensis+live+vaccine+strain+infection+in+B-cell-deficient+mice+is+associated+with+neutrophilia+but+not+with+defects+in+specific+T-cell-mediated+immunity&rft.au=Bosio%2C+C+M%3BElkins%2C+K+L&rft.aulast=Bosio&rft.aufirst=C&rft.date=2001-01-01&rft.volume=69&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Francisella tularensis; Vaccines; Neutrophilia; Lymphocytes T; Immune response (cell-mediated); Lymphocytes B; ^g-Interferon; Nitric oxide; Tularemia ER - TY - JOUR T1 - Psychosocial work stress in female funeral service practitioners AN - 1318693768; 17270900 AB - Suggests that female funeral service practitioners (FSPs), in particular, may be exposed to a combination of classic healthcare stressors (e.g. shift work, work/family balance), unique funeral industry stressors, and stresses associated with working in non-traditional occupations. Explores the relationships betweeen the stressors, perceived stress and two m ental health outcomes: anxiety and depression. Suggests that there needs to be both direct and indirect relationships between these. Expands the knowledge regarding the types of work and non-work stressor that can affect mental health outcomes among women working in onn-traditional occupations. Comments that this information should be particularly useful as women are increasingly entering historically male-dominated fields. JF - Equal Opportunities International AU - Goldenhar, Linda M AU - Gershon, Robyn AU - Mueller, Charles AU - Karkasian, Christine AU - Swanson, Naomi A AD - National Institute For Occupational Safety and Health, Cincinnati Y1 - 2001 PY - 2001 DA - 2001 SP - 17 EP - 38 PB - Emerald Group Publishing Limited, 60-62 Toller Lane Bradford West Yorkshire BD8 9BY United Kingdom VL - 20 IS - 1-2 SN - 0261-0159, 0261-0159 KW - Health & Safety Science Abstracts KW - Depression KW - Females KW - Health care KW - Historical account KW - Occupational health KW - Perception KW - Shift work KW - Stress KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1318693768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Equal+Opportunities+International&rft.atitle=Psychosocial+work+stress+in+female+funeral+service+practitioners&rft.au=Goldenhar%2C+Linda+M%3BGershon%2C+Robyn%3BMueller%2C+Charles%3BKarkasian%2C+Christine%3BSwanson%2C+Naomi+A&rft.aulast=Goldenhar&rft.aufirst=Linda&rft.date=2001-01-01&rft.volume=20&rft.issue=1-2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Equal+Opportunities+International&rft.issn=02610159&rft_id=info:doi/10.1108%2F02610150110786688 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Historical account; Shift work; Depression; Health care; Perception; Stress; Females; Working conditions; Occupational health DO - http://dx.doi.org/10.1108/02610150110786688 ER -